Iron absorption during recovery from malnutrition.
OBJECTIVE
In infants and children recovering from severe malnutrition, iron deficiency is common, and the ability to absorb iron during such recovery is uncertain. The objective of this study was to determine iron absorption during recovery from malnutrition.


METHODS
During the later stages of recovery from malnutrition, erythrocyte incorporation of orally administered 58Fe was determined as a surrogate for iron absorption. Based on four indices, subjects were classified as iron-sufficient, iron-deficient or indeterminate.


RESULTS
Of the 25 subjects, 9 were classified as iron sufficient, 5 as indeterminate and 11 as iron deficient; all but 5 had evidence of inflammation or infection. Geometric mean erythrocyte incorporation of 58Fe was 32.0% of the dose in the iron-deficient subjects, which was not significantly different (p = 0.073) than the 13.1% in the iron-sufficient subjects. Incorporation of 58Fe by the iron-sufficient subjects did not differ significantly from that by normal subjects in the same age range. Surprisingly, we found no correlation of erythrocyte incorporation of 58Fe and reticulocyte count.


CONCLUSIONS
Even in the presence of infection or inflammation, iron absorption by children during a late stage of recovery from malnutrition is not impaired.
Vasquez Garibay
E
E
Instituto de Nutricion Humana, Hospital Civil Dr. Juan L Menchaca, Universidad de Guadalajara, Jalisco, Mexico.
Santos Torres
I
I
Nelson
S E
SE
Ziegler
E E
EE
Rogers
R R
RR
Janghorbani
M
M
Fomon
S J
SJ
D000042:Absorption; D001827:Body Height; D001835:Body Weight; D002675:Child, Preschool; D015331:Cohort Studies; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007501:Iron / Q000097:blood / Q000493:pharmacokinetics*; D000090463:Iron Deficiencies; D007503:Iron Isotopes; D008297:Male; D009748:Nutrition Disorders / Q000378:metabolism* / Q000628:therapy; D017701:Reticulocyte Count
D007503:Iron Isotopes; D007501:Iron