Protein kinases: getting NEKed for S6K activation.
The 70/85 kDa ribosomal protein S6 kinase is regulated through the concerted actions of multiple phosphatases and kinases. A newly identified S6 kinase kinase, NEK6, appears to provide the penultimate activation step.
Templeton
D J
DJ
Department of Pathology, University of Virginia Medical School, PO Box 800214, Charlottesville, VA 22908-0214, USA. Templeton@virginia.edu
D000595:Amino Acid Sequence; D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000378:metabolism; D019893:Ribosomal Protein S6 Kinases / Q000737:chemistry / Q000378:metabolism*
D011494:Protein Kinases; D019893:Ribosomal Protein S6 Kinases