title: Evaluation of European tick-borne encephalitis virus vaccine against recent Siberian and far-eastern subtype strains.
abstract: To evaluate the efficacy of the European TBE vaccine in east-Siberian and far-eastern regions of Russia, we examined the immune responses of the vaccine against recent TBE virus Siberian (Irkutsk) and far-eastern (Khabarovsk and Vladivostok) isolates. The sera of vaccinated humans showed efficient neutralizing antibody titers (> or =20) against Siberian and far-eastern strains. To evaluate the efficacy of the vaccine in vivo, mice were vaccinated and challenged with lethal doses of the viruses. All vaccinated mice survived each virus challenge. These results suggest that the European vaccine can prevent the TBE virus infection in east-Siberian and far-eastern regions of Russia.
authors.affiliation: Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, 060-0818, Sapporo, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Hayasaka
authors.forename: A
authors.initials: A
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Yoshii
authors.forename: T
authors.initials: T
authors.lastname: Mizutani
authors.forename: H
authors.initials: H
authors.lastname: Kariwa
authors.forename: I
authors.initials: I
authors.lastname: Takashima
mesh_terms: D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D004669:Encephalitis Viruses, Tick-Borne / Q000145:classification* / Q000276:immunology; D004675:Encephalitis, Tick-Borne / Q000276:immunology*; D006801:Humans; D018884:Ixodes / Q000821:virology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008875:Middle Aged; D009500:Neutralization Tests; D012800:Siberia; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D014765:Viral Vaccines