An orthotopic xenograft model of human nonseminomatous germ cell tumour.
We have established the first example of an orthotopic xenograft model of human nonseminomatous germ cell tumour (NSGCT). This reproducible model exhibits many clinically relevant features including metastases to the retroperitoneal lymph nodes and lungs, making it an ideal tool for research into the development and progression of testicular germ cell tumours.
Douglas
M L
ML
Department of Surgery, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland 4102, Australia.
Boucaut
K J
KJ
Antalis
T M
TM
Higgins
C
C
Pera
M F
MF
Stuttgen
M A
MA
Nicol
D L
DL
D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured