Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury.
The effects of i.c.v. injection of AIDA, a group I mGluR antagonist, were studied on the nigral DA cells after MPTP-induced injury in the black mouse, using TH immunocytochemistry and unbiased stereology. MPTP reduced the total number of TH-IR neurons by 55.2% and non-TH-IR neurons by 27.5%. A 15 min AIDA pre-treatment (10 nmol) selectively counteracted the loss of TH-IR cells caused by MPTP as evaluated 10 days after the insult without changing the total number of non-neuronal cell nuclei. The results suggest that group I mGluR antagonists may have a neuroprotective role against MPTP-induced degeneration of DA neurons and thus probably also against neurodegenerative processes occurring in Parkinson's disease.
Aguirre
J A
JA
Department of Physiology, School of Medicine, E-29080, Málaga, Spain.
Andbjer
B
B
González-Barón
S
S
Hansson
A
A
Strömberg
I
I
Agnati
L F
LF
Fuxe
K
K
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage; D000818:Animals; D002452:Cell Count; D048429:Cell Size / Q000187:drug effects; D004396:Coloring Agents; D004298:Dopamine / Q000378:metabolism*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage*; D007150:Immunohistochemistry; D007189:Indans / Q000008:administration & dosage*; D007276:Injections, Intraventricular; D020267:MPTP Poisoning / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D013378:Substantia Nigra / Q000187:drug effects* / Q000473:pathology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000096:biosynthesis
C095756:1-aminoindan-1,5-dicarboxylic acid; D004396:Coloring Agents; D018691:Excitatory Amino Acid Antagonists; D007189:Indans; D018696:Neuroprotective Agents; D018094:Receptors, Metabotropic Glutamate; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine