Synthesis and pharmacological activities of some new 2-[1-(6-methoxy-2-naphthyl)ethyl]-6-(substituted)benzylidene thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one derivatives.
In this study, thirteen new compounds having a 2-[1-(6-methoxy-2-naphthyl)ethyl]-6-(substituted)benzylidenethiazolo[3,2-b]- 1,2,4-triazole-5(6H)-one structure were synthesised using N-[2-(6-methoxy-2-naphthyl)propanoyloxysuccinimide, N-[2-(6-methoxy-2-naphthyl)propanoyl]thiosemicarbazide and 3-[1-(6-methoxy-2-naphthyl)ethyl]-5-mercapto-1,2,4-triazole. The structures and physical properties of the compounds were elucidated by IR, 1H NMR, mass spectroscopy and elemental analysis. The antiinflammatory activity and gastric ulceration potential of the compounds were tested using naproxen as a reference compound.
Berk
B
B
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University. bberk@hacettepe.edu.tr
Aktay
G
G
Yesilada
E
E
Ertan
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002351:Carrageenan; D002855:Chromatography, Thin Layer; D003500:Cyclization; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D008297:Male; D051379:Mice; D009281:Naphthalenes / Q000737:chemistry*; D009288:Naproxen / Q000494:pharmacology / Q000633:toxicity; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology; D013844:Thiazoles / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009281:Naphthalenes; D013844:Thiazoles; D009288:Naproxen; D002351:Carrageenan