Cardiovascular reactivity to and renal impact of stress and exercise: effects of bisoprolol.
The orthosympathetic nervous system is involved in the pathogenesis of essential hypertension. In this study, we carried out tests of sympathetic stimulation using successfully an isometric exercise and a psychological stress. The efficacy of the two tests in 10 normotensive patients (NTs) was assessed by a significant increase in blood pressure and heart rate and a significant increase in metanephrine urinary excretion. These tests, repeated 2 months later, were perfectly reproducible in NTs. The cardiovascular response during exercise and stress was significantly higher in 10 hypertensive patients (HTs) than in NTs. At rest, urinary norepinephrine excretion was significantly higher in HTs. In contrast to NTs, stress in HTs significantly increased urinary excretion of epinephrine and norepinephrine, whereas exercise failed to increase urinary catecholamine excretion in both groups. In HTs, both tests induced an increase in microalbuminuria. Among functional renal parameters, only proximal sodium reabsorption (measured by lithium clearance) was significantly lower in HTs than in NTs, compensated by a higher distal reabsorption. In HTs, 2 months of treatment with bisoprolol reduced rest and peak heart rate and blood pressure, but failed to reduce blood pressure reactivity to the orthosympathetic stimulation. Proximal sodium reabsorption at rest was normalized by the treatment. Bisoprolol was also able to reduce microalbuminuria during the 24 h and in the rest period preceding the test, but the same percent increase was observed during tests.
Fauvel
J P
JP
Département de Néphrologie et d'Hypertension Artérielle, Exploration Fonctionnelle Renale, Hôpital Edouard Herriot, INSERM U 80, CNRS UA 1177, Lyon, France.
Hadj-Aissa
A
A
Laville
M
M
Pozet
N
N
Bernard
N
N
Sassard
J
J
Zech
P
P
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D000419:Albuminuria / Q000188:drug therapy / Q000652:urine; D017298:Bisoprolol / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002395:Catecholamines / Q000652:urine*; D015444:Exercise / Q000502:physiology; D005080:Exercise Test / Q000379:methods; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000652:urine*; D008297:Male; D018709:Statistics, Nonparametric; D013315:Stress, Psychological / Q000652:urine*
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D017298:Bisoprolol