title: Target controlled infusion of remifentanil and propofol for cesarean section in a patient with multivalvular disease and severe pulmonary hypertension.
abstract: A 36 year old parturient with known valvular heart disease was admitted with respiratory distress and fatigue after 35 weeks of pregnancy. Echocardiography revealed severe tricuspid regurgitation, mitral stenosis and aortic valve insufficiency. Following clinical examination and insertion of a radial and pulmonary artery catheter it was decided to perform a Caesarean Section. The pulmonary artery pressure upon arrival in the operating theatre was 105/50 mm Hg whereas cardiac output was 3.5 l/min. Induction of anesthesia was performed with a target controlled infusion of remifentanil and propofol combined with rocuronium bromide. Haemodynamic variables remained very stable during and after intubation. The lungs of the apnoeic baby were manually ventilated until spontaneous respiration began at 1 minute post delivery. Apgar scores were 3, 7 and 9 after 1, 5 and 10 minutes respectively. Umbilical artery pH was 7.29. The patient's haemodynamic status gradually improved over the following few days. Two months following delivery she underwent unevenful valvular surgery.
authors.affiliation: Dept. of Anesthesia, University Hospital Antwerp, Wilrijkstraat 10, B-2650 Edegem, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Mertens
authors.forename: V
authors.initials: V
authors.lastname: Saldien
authors.forename: H
authors.initials: H
authors.lastname: Coppejans
authors.forename: K
authors.initials: K
authors.lastname: Bettens
authors.forename: M
authors.initials: M
authors.lastname: Vercauteren
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D000773:Anesthesia, Obstetrical; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D002585:Cesarean Section; D005260:Female; D006349:Heart Valve Diseases; D006801:Humans; D006976:Hypertension, Pulmonary; D007260:Infusion Pumps; D010880:Piperidines / Q000008:administration & dosage*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D015742:Propofol / Q000008:administration & dosage*; D000077208:Remifentanil
chemical_list: D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol