Focal nodular hyperplasia with calcification and ossification.
We describe a 33-year-old woman with Crohn's disease, who presented with recurrent episodes of small bowel obstruction. A solitary liver lesion was discovered incidentally by abdominal ultrasound. Pathological examination of the resected specimen revealed features typical of focal nodular hyperplasia together with uncommon findings including calcification, ossification and fibrous obliteration of blood-filled "cysts", changes more commonly associated with regression in hepatic haemangiomas. This report strengthens the favoured hypothesis that a vascular malformation underlies the pathogenesis of focal nodular hyperplasia.
Langman
G
G
Department of Anatomical Pathology, University of Cape Town Medical School, South Africa.
Hall
P D
PD
D000328:Adult; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology*; D003424:Crohn Disease / Q000150:complications / Q000473:pathology; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000473:pathology*; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography