title: Effects of buflomedil on early carotid atherosclerosis in Type 2 diabetic patients.
abstract: BACKGROUND
  An increased thickness of the carotid artery wall is thought to be a sign of early atherosclerosis. We have investigated the effect of early treatment with buflomedil on the prevention of the arterial wall thickening.
  
  
  METHODS
  Eighty patients with Type 2 diabetes were studied. Oral buflomedil (600 mg once daily) was administered for 12 months in 42 patients randomly selected, while 38 received no treatment. The two groups were matched for age, sex, body mass index (BMI), duration of diabetes and glycaemic control. Arterial wall thickness was measured as the mean of the maximum intima media thickness (IMT) in 8 carotid segments measured by B-mode ultrasound.
  
  
  RESULTS
  Blood pressure and lipid levels remained unchanged in the two studied groups while no difference was found in metabolic control between them. The IMT increase over 12 months was 0.04 mm in the buflomedil group whereas in that without buflomedil it was 0.10 mm.
  
  
  CONCLUSIONS
  We conclude that buflomedil treatment may be useful in decreasing the progression rate of arterial wall thickness.
authors.affiliation: Department of Diabetes, NIMTS Hospital, Athens, Greece.
authors.forename: I N
authors.initials: IN
authors.lastname: Migdalis
authors.forename: N
authors.initials: N
authors.lastname: Varvarigos
authors.forename: J
authors.initials: J
authors.lastname: Charalabides
authors.forename: E
authors.initials: E
authors.lastname: Leontiades
authors.forename: B
authors.initials: B
authors.lastname: Gerolimou
authors.forename: F
authors.initials: F
authors.lastname: Mantzara
authors.forename: K
authors.initials: K
authors.lastname: Karmaniolas
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D002340:Carotid Artery Diseases / Q000188:drug therapy* / Q000209:etiology*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000187:drug effects; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011759:Pyrrolidines / Q000627:therapeutic use*; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000187:drug effects; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008055:Lipids; D010975:Platelet Aggregation Inhibitors; D011759:Pyrrolidines; C010651:buflomedil