title: Generation of (E)-silylketene acetals in a Rhodium-DuPhos catalyzed two-step reductive aldol reaction.
abstract: [reaction: see text]. Mechanistic studies employing in situ NMR analysis implicate intermediate silicon enolates as reactive intermediates in the Rh-DuPhos catalyzed two-step reductive aldol reaction with Cl(2)MeSiH. These enolates undergo noncatalyzed reaction with a variety of aldehydes to give the derived syn-aldol adduct in high yields and diastereoselection.
authors.affiliation: Department of Chemistry, Venable and Kenan Laboratories, The University of North Carolina at Chapel Hill, 27599-3290, USA.
authors.forename: C X
authors.initials: CX
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Bass
authors.forename: J P
authors.initials: JP
authors.lastname: Morken