title: Successful prevention of recurrent ventricular fibrillation by intravenous isoproterenol in a patient with Brugada syndrome.
abstract: Intravenous administration of isoproterenol restored the ST-segment configuration to nearly normal in the right precordial leads and completely prevented spontaneous VF attacks in a patient with Brugada syndrome. The formation of a Brugada-type ECG has been attributed to the transmural dispersion of repolarization of the right ventricular epicardium and related to modulation of the autonomic nervous system. Our case may provide clues to the pathophysiological mechanism of this syndrome.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: O
authors.initials: O
authors.lastname: Kinoshita
authors.forename: S
authors.initials: S
authors.lastname: Uchikawa
authors.forename: H
authors.initials: H
authors.lastname: Kasai
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Izawa
authors.forename: O
authors.initials: O
authors.lastname: Yokoseki
authors.forename: H
authors.initials: H
authors.lastname: Kitabayashi
authors.forename: W
authors.initials: W
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Yazaki
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Imamura
authors.forename: K
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000328:Adult; D002037:Bundle-Branch Block / Q000150:complications*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D004562:Electrocardiography; D006801:Humans; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000627:therapeutic use*; D008297:Male; D012008:Recurrence; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000209:etiology / Q000517:prevention & control*
chemical_list: D002316:Cardiotonic Agents; D007545:Isoproterenol