title: In vitro studies of the anticalculus efficacy of a sodium hexametaphosphate whitening dentifrice.
abstract: Laboratory studies involving crystal growth inhibition and plaque biofilm calcification were conducted to confirm the anticalculus potential of a dual-action whitening dentifrice containing sodium hexametaphosphate, a novel, enamel-safe, antitartar agent. Calcium hydroxyapatite crystal growth was significantly inhibited following direct supernate treatments by hexametaphosphate in solution and when formulated into the dual-action whitening dentifrice. Similarly, plaque biofilm calcification was significantly inhibited by supernate treatments of the hexametaphosphate whitening dentifrice. The activity of hexametaphosphate dentifrice in plaque biofilm calcification protocols exceeded that produced by commercial dentifrices containing polycarboxylic acid, metal ion and pyrophosphate tartar control ingredients. Results predict excellent clinical activity for hexametaphosphate dentifrice for the prevention of supragingival calculus formation. Published double-blind, randomized clinical studies confirm the validity of these laboratory models for the screening of potentially improved tartar control ingredients.
authors.affiliation: Procter & Gamble Company, Health Care Research Center, Mason, OH, USA. White.DJ.1@pg.com
authors.forename: Donald  J
authors.initials: D
authors.lastname: White
authors.forename: Ed  R
authors.initials: E
authors.lastname: Cox
authors.forename: Elaine  M
authors.initials: E
authors.lastname: Suszcynskymeister
authors.forename: Arif A
authors.initials: AA
authors.lastname: Baig
mesh_terms: D045424:Complex Mixtures; D003460:Crystallization; D003728:Dental Calculus / Q000517:prevention & control*; D003773:Dental Plaque / Q000737:chemistry; D003802:Dentifrices / Q000627:therapeutic use*; D011756:Diphosphates / Q000627:therapeutic use; D004338:Drug Combinations; D017886:Durapatite / Q000737:chemistry; D005459:Fluorides; D006863:Hydrogen-Ion Concentration; D010710:Phosphates / Q000627:therapeutic use*; D012824:Silicic Acid; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014073:Tooth Bleaching; D014100:Toothpastes; D014260:Triclosan
chemical_list: D045424:Complex Mixtures; C438183:Crest Dual Action Whitening dentifrice; C098422:Crest Tartar Control; D003802:Dentifrices; D011756:Diphosphates; D004338:Drug Combinations; D010710:Phosphates; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D014260:Triclosan; D012969:Sodium Fluoride; D017886:Durapatite; C009285:sodium polymetaphosphate; D005459:Fluorides