Role of pharmacokinetics and pharmacodynamics: does the dose matter?
Antibiotic dose is important in determining serum area-under-the-curve (AUC) and peak serum concentration (C(max)), as well as the time the serum concentration remains over the pathogen minimum inhibitory concentration (T>MIC). However, dose is not the sole determinant of these factors; they are modified by absorption, clearance, and frequency of dosing. It is difficult to relate dose to clinical outcome in humans, but pharmacodynamic parameters (AUC/MIC, C(max)/MIC, or T>MIC) have been related to clinical and bacteriological efficacy or emergence of resistance to aminoglycosides, fluoroquinolones, glycopeptides, and beta-lactams.
MacGowan
A P
AP
Bristol Centre for Antimicrobial Research & Evaluation, North Bristol National Health Service Trust, Westbury-on-Trym, Bristol, United Kingdom. macgowan_a@southmead.swest.nhs.uk
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D024841:Fluoroquinolones; D006020:Glycopeptides; D006801:Humans; D007769:Lactams; D010599:Pharmacokinetics
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D006020:Glycopeptides; D007769:Lactams