title: Synthesis and properties of 18F-labeled potential myocardial blood flow tracers.
abstract: PET centers without particle accelerators make clinical PET widely available at reduced cost. For myocardial perfusion tracers, these satellite PET centers are limited to generator- produced 82Rb(+) and 62Cu[PTSM]. Their limitations motivate a search for transportable alternatives. In search of new tracers we have synthesized several 18F-labeled amines and quaternary ammonium salts. Among them, 4-[18F]fluorotri-N-methylanilinium ([18F]FTMA) has flow-tracing properties. The compound is functional, but has properties that justify a continued search.
authors.affiliation: Department of Chemistry, Case Western Reserve University, University Hospital of Cleveland, Cleveland, OH 44106, USA. ars5@po.cwru.edu
authors.forename: A R
authors.initials: AR
authors.lastname: Studenov
authors.forename: M S
authors.initials: MS
authors.lastname: Berridge
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003326:Coronary Circulation; D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
chemical_list: D002800:Cholinesterase Inhibitors; D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated