Synthesis of 3-nitrosoimidazo[1,2-a]pyridine derivatives as potential antiretroviral agents.
Ten 2-aryl or heteroaryl-3-nitrosoimidazo[1,2-a]pyridine derivatives were synthesised as potential antiretroviral agents. The new compounds were characterized by elemental analysis, 1H NMR, and by crystallography for (14). The compounds were devoid of any activity against HIV-1 or HIV-2.
Chaouni-Benabdallah
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A
E.A. 3247 Groupe de Recherche en Chimie Hétérocyclique et Thérapeutique, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 31 Avenue Monge, 37200 Tours, France. enguehard@univ-tours.fr
Galtier
C
C
Allouchi
H
H
Kherbeche
A
A
Debouzy
J C
JC
Teulade
J C
JC
Chavignon
O
O
Witvrouw
M
M
Pannecouque
C
C
Balzarini
J
J
de Clercq
E
E
Enguehard
C
C
Gueiffier
A
A
D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D002478:Cells, Cultured; D018360:Crystallography, X-Ray; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009603:Nitroso Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012190:Retroviridae / Q000187:drug effects*
C434769:3-nitrosoimidazo(1,2-a)pyridine; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D007093:Imidazoles; D009603:Nitroso Compounds; D011725:Pyridines