Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.
Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma. The findings from transbronchial lung biopsy and bronchoalveolar lavage (BAL) were consistent with an organizing diffuse alveolar damage pattern. Once extensive microbiological studies proved negative, corticosteroids were given and a complete remission of clinical and radiological abnormalities was achieved. It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.
Trisolini
R
R
Dept Thoracic Diseases, Bellaria and Maggiore Hospitals, Bologna, Italy.
Lazzari Agli
L
L
Tassinari
D
D
Rondelli
D
D
Cancellieri
A
A
Patelli
M
M
Falcone
F
F
Poletti
V
V
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D012004:Rectal Neoplasms / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D005472:Fluorouracil