Structure-activity relationship studies of isoquinolinone type anticancer agent.
Substituted isoquinolin-1-ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-N-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.
Cheon
S H
SH
College of Pharmacy, Chonnam National University, Kwangju, Korea. shcheon@chonnam.ac.kr
Park
J S
JS
Lee
J Y
JY
Lee
Y N
YN
Yi
H
H
Chung
B H
BH
Choi
B G
BG
Cho
W J
WJ
Choi
S U
SU
Lee
C O
CO
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D007546:Isoquinolines