title: Fear conditioning in inbred mouse strains: an analysis of the time course of memory.
abstract: Three mouse strains were examined for short- and long-term memory for Pavlovian fear conditioning measured 1 hr and 24 hr after conditioning. Both DBA/2J and CBA/J mice exhibit reduced long-term memory for contextual fear conditioning compared with C57BL/6J mice. In cued fear conditioning, however, DBA/2J mice show reduced short- and long-term memory compared with C57BL/6J mice, whereas CBA/J mice exhibit reductions only in short-term memory. These results underscore the importance of examining the time course of memory retention, and they suggest that inbred mouse strains may provide a diversity of phenotypes. The results also suggest that the processes of short- and long-term memory storage as well as contextual and cued fear conditioning are dissociable and are mediated by genetically distinct neurobiological mechanisms.
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, 19104-6018, USA.
authors.forename: T
authors.initials: T
authors.lastname: Nie
authors.forename: T
authors.initials: T
authors.lastname: Abel
mesh_terms: D000818:Animals; D003214:Conditioning, Classical; D003463:Cues; D005239:Fear / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains / Q000235:genetics / Q000502:physiology*; D010641:Phenotype; D013997:Time Factors