Ethanol-related adaptive changes and physical dependence in rats after exposure to ethanol.
Adaptive changes that occur after chronic exposure to ethanol are an important component in the development of physical dependence. We have focused our research on ethanol-induced changes in the expression of several genes that may be important in adaptation. In this article, we describe adaptive changes at the level of the N-methyl-D-aspartate receptor, in the protein expression and activity of the Egr transcription factors, and in the expression of a novel gene of unknown function.
Wilce
P A
PA
Alcohol Research Unit, Department of Biochemistry, The University of Queensland, St. Lucia, Queensland, Australia 4072. wilce@biosci.uq.edu.au
Depaz
I
I
Hardy
P
P
Davidson
M
M
Jaquet
V
V
D000222:Adaptation, Physiological / Q000502:physiology*; D000437:Alcoholism / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology; D051766:Early Growth Response Protein 1; D051767:Early Growth Response Protein 2; D000431:Ethanol / Q000494:pharmacology*; D015870:Gene Expression; D017874:Immediate-Early Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics; D020033:Protein Isoforms / Q000378:metabolism; D051381:Rats / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology
D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; D051767:Early Growth Response Protein 2; C486110:Egr1 protein, rat; C497328:Egr2 protein, rat; D017874:Immediate-Early Proteins; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D016194:Receptors, N-Methyl-D-Aspartate; C486029:Tagln3 protein, rat; D014157:Transcription Factors; D000431:Ethanol