[Chronic gastroduodenal erosions: clinical and pathogenetic characteristics, classification, differential treatment].
The etiology of chronic (complete) gastroduodenal erosions is not quite clear and is apparently multifactorial. A total of 100 patients with chronic gastroduodenal erosions were examined and divided into 5 representative groups, 20 pts each. For objective evaluation of the significance of various (probable) etiological and pathogenetic factors in development of chronic erosions, monotherapies with drugs with known pharmacodynamic effects were used (ranitidine, double and triple antihelicobacter protocols, dalargin, trental). Triple antihelicobacter protocol and trental proved to be the most effective in the treatment of chronic erosions (90 and 85%, respectively). Dalargin and double antihelicobacter protocol caused disappearance of complete erosions in 50% patients and ranitidine in only 15%. Analysis of the frequency of erosion epithelialization and Helicobacter pylori eradication under the effect of antibiotics showed a clear-cut positive correlation (r = 0.9) between these parameters, which indicated an important role of Helicobacter pylori in the pathogenesis of chronic gastroduodenal erosions. Moderate antihelicobacter activity of dalargin was revealed for the first time. The results of this study indicate that the majority of complete erosions are an individual nosological entity. Microcirculatory disorders in the antral part of the gastric mucosa and its contamination with Helicobacter pylori play an important role in the disease development; decreased cytoprotection and local immunity in the antral part of the stomach are also. The acidopeptic factor cannot cause complete erosions but is one of conditions for their formation.
Tsimmerman
Ia S
IaS
Vedernikov
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VE
D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000145:classification / Q000188:drug therapy / Q000503:physiopathology
D000890:Anti-Infective Agents
Khronicheskie gastroduodenal'nye érozii: kliniko-patogeneticheskaia kharakteristika, klassifikatsiia, differentsirovannoe lechenie.