title: Continuous surveillance of organochlorine compounds in human breast milk from 1972 to 1998 in Osaka, Japan.
abstract: The presence of chlorinated organic compounds in breast milk of lactating women living in Osaka Prefecture, Japan, has been followed since 1972. Following the highest concentration found at the start of the measurements, contamination by polychlorinated biphenyls (PCBs) and organochlorine pesticides, such as beta-HCH and DDT declined to about 3-13% of the peak levels by the mid-1970s and continued to decrease to low-level equilibrium states. This decline varies greatly with the chemical compound. In comparison with 1970s, when the contamination of breast milk was highest, the beta-HCH level fell to about 3%, DDT to about 7%, and PCBs to about 13%, representative of different half-lives in the environment and the particular persistence of PCB. In the case of chlordane, a termite insecticide, more than 10 years have passed since its use was prohibited in Japan, but it continues to be found in human breast milk, although at a low level.
authors.affiliation: Osaka Prefectural Institute of Public Health, Division of Food Hygiene, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Konishi
authors.forename: K
authors.initials: K
authors.lastname: Kuwabara
authors.forename: S
authors.initials: S
authors.lastname: Hori
mesh_terms: D000328:Adult; D003634:DDT / Q000032:analysis* / Q000493:pharmacokinetics; D004785:Environmental Pollutants / Q000032:analysis* / Q000493:pharmacokinetics; D005260:Female; D005506:Food Contamination; D006306:Health Surveys; D001556:Hexachlorocyclohexane / Q000032:analysis* / Q000493:pharmacokinetics; D006801:Humans; D007564:Japan; D008895:Milk, Human / Q000737:chemistry*; D012275:Oryza / Q000737:chemistry; D010571:Pest Control; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000493:pharmacokinetics
chemical_list: D004785:Environmental Pollutants; D001556:Hexachlorocyclohexane; D003634:DDT; D011078:Polychlorinated Biphenyls; C023888:beta-hexachlorocyclohexane