title: Role still exists for cycler therapy in anuric patients with a low-transport membrane.
abstract: It is generally believed that, to achieve adequacy targets, anuric patients with a low-transport membrane should be treated by continuous ambulatory peritoneal dialysis (CAPD) or CAPD with a night-exchange device. If adequacy targets are not reached, it is suggested that patients should be changed to hemodialysis. We would like to show that a role still exists for cycler + therapy (cycler therapy with a wet day or with only one manual exchange) in these patients, both for obtaining target Kt/V and for lifestyle. Using the PD Adequest computer program (Baxter Healthcare Corporation, Deerfield, IL, U.S.A.), we compared a night-exchange device [3 exchanges during the day and 2 exchanges during the night (3 + 2)] to various regimes of cycler + therapy. In all cases, the night-exchange volume exceeded the day-exchange volume by 500 mL. Using cycler + therapy in anuric patients with a low-transport membrane, with 6-7 exchanges over 9 hours, Kt/V can be increased by 10%-25%. A role therefore still exists for cycler + therapy in anuric patients with a low-transport membrane for lifestyle or to achieve a better Kt/V. Unfortunately, we saw no significant improvement in creatinine clearance.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Ottawa and Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: D E
authors.initials: DE
authors.lastname: Pagé
authors.forename: V
authors.initials: V
authors.lastname: Cheung
mesh_terms: D001002:Anuria / Q000378:metabolism / Q000628:therapy*; D001692:Biological Transport; D003404:Creatinine / Q000378:metabolism; D006801:Humans; D010530:Peritoneal Dialysis / Q000379:methods*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods; D010537:Peritoneum / Q000378:metabolism*; D014508:Urea / Q000378:metabolism
chemical_list: D014508:Urea; D003404:Creatinine