title: Do adolescent smokers experience withdrawal effects when deprived of nicotine?
abstract: This is the first controlled prospective study of the effects of nicotine deprivation in adolescent smokers. Heart rate and subjective withdrawal symptoms were measured over an 8-hr period while participants smoked normally. Seven days later, participants were randomized to wear a 15-mg (16-hr) nicotine patch or a placebo patch for 8 hr, and they refrained from smoking during the session. Those wearing the placebo experienced a decrease in heart rate across sessions and an increase in subjective measures of nicotine withdrawal. Those wearing the active patch also reported significant increases for some subjective symptoms. Expectancy effects were also observed. The findings indicate that adolescent smokers experience subjective and objective changes when deprived of nicotine. As in previous research with adults, expectancies concerning the effects of nicotine replacement also influenced perceptions of withdrawal.
authors.affiliation: Department of Medicine, Center for Research in Disease Prevention, Stanford University School of Medicine, Palo Alto, California 94304-1885, USA. jkillen@stanford.edu
authors.forename: J D
authors.initials: JD
authors.lastname: Killen
authors.forename: S
authors.initials: S
authors.lastname: Ammerman
authors.forename: N
authors.initials: N
authors.lastname: Rojas
authors.forename: J
authors.initials: J
authors.lastname: Varady
authors.forename: F
authors.initials: F
authors.lastname: Haydel
authors.forename: T N
authors.initials: TN
authors.lastname: Robinson
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D002248:Carbon Monoxide / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D000297:Psychology, Adolescent; D012907:Smoking / Q000523:psychology*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000523:psychology*; D020340:Tobacco Use Cessation / Q000523:psychology*
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine; D002248:Carbon Monoxide