title: Safety and efficacy of beta-blockers in the treatment of stable angina pectoris.
abstract: In stable exercise-induced angina pectoris, beta-blockers exert their beneficial effects mainly through a reduction in heart rate, blood pressure. and contractility. Additional beneficial effects are an improvement in myocardial oxygen supply through a redistribution of coronary flow, a lengthening of diastole, a facilitation of aerobic metabolism, and a rightward shift of the oxygen-hemoglobin dissociation curve. Cardioselective beta-blockers can be expected to have fewer side effects than the nonselective drugs. Apart from a reduction in anginal attack rate and an improvement in exercise capacity, a reduction in silent ischemia may be desirable when treating patients with stable effort angina, beta-blockers effectively reduce asymptomatic ischemia. Bisoprolol is a new beta1-selective beta-blocker with a clear 24-h duration of action regarding symptoms and improvement of exercise capacity in patients with stable exercise-induced angina pectoris. Bisoprolol 10 mg and atenolol 100 mg are equipotent in achieving these effects.
authors.affiliation: Department of Cardiology, Thoraxcenter, Academisch Ziekenhuis Groningen, The Netherlands.
authors.forename: E D
authors.initials: ED
authors.lastname: de Muinck
authors.forename: K I
authors.initials: KI
authors.lastname: Lie
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000188:drug therapy*; D000818:Animals; D017298:Bisoprolol / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D017202:Myocardial Ischemia / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D017298:Bisoprolol