title: Photoinduced DNA cleavage by cyclopentadienyl metal complexes conjugated to DNA recognition elements.
abstract: [structure: see text]. DNA recognition elements have been attached to CpW(CO)3CH3 and CpW(CO)3Ph, which produce methyl and phenyl radicals that cleave DNA upon photolysis. The inclusion of binding moieties in 3 increases the efficiency but not the selectivity of strand scission over that seen in the simple unfunctionalized complex, while 11 cleaves preferentially at T sites within AT-rich tracts.
authors.affiliation: Department of Chemistry, Emory University, 1515 Pierce Dr., Atlanta, Georgia 30322, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Hurley
authors.forename: M P
authors.initials: MP
authors.lastname: Maddox
authors.forename: T L
authors.initials: TL
authors.lastname: Scott
authors.forename: M R
authors.initials: MR
authors.lastname: Flood
authors.forename: D L
authors.initials: DL
authors.lastname: Mohler
mesh_terms: D003517:Cyclopentanes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000528:radiation effects*; D010777:Photochemistry; D010957:Plasmids; D014414:Tungsten / Q000737:chemistry*
chemical_list: D003517:Cyclopentanes; D004247:DNA; D014414:Tungsten