title: Bacterial supplementation in the irritable bowel syndrome. A randomised double-blind placebo-controlled crossover study.
abstract: BACKGROUND
  Symptoms of at least a subgroup of patients with irritable bowel syndrome may be associated with an alteration in gut flora. Studies on bacterial based therapy have yielded mixed results.
  
  
  OBJECTIVE
  To determine if oral administration of the probiotic Lactobacillus casei strain GG under randomized placebo controlled conditions improves symptoms in irritable bowel syndrome patients with bloating related symptoms.
  
  
  METHODS
  A total of 25 patients with clinically confirmed irritable bowel syndrome (Rome criteria) were enrolled in the study.
  
  
  METHODS
  This was a randomised double-blind placebo-controlled crossover trial. Lactobacillus GG was administered as enterocoated tablets constituting a daily dosage of 10(10) colony forming units. Symptoms were assessed by daily symptom diaries and periodic questionnaires.
  
  
  RESULTS
  Twenty-four patients were randomised; 19 (80%) female, mean age 40 years (range 24-60), mean duration of symptoms 4.9 years (range 0.5-18). Nineteen (80%) patients completed the study. No significant differences were found between Lactobacillus casei strain GG and placebo mean symptom scores for pain, urgency or bloating. A trend was noted, however, for a reduction in the number of unformed bowel motions on Lactobacillus casei strain GG treatment for patients with diarrhoea.
  
  
  CONCLUSIONS
  Lactobacillus casei strain GG alone did not significantly improve symptoms in this irritable bowel syndrome subgroup. A "diarrhoea predominant" subgroup may warrant further investigation.
authors.affiliation: Department of Gastroenterology, Adelaide & Meath Hospital, Tallaght, Dublin, Ireland.
authors.forename: M A
authors.initials: MA
authors.lastname: O'Sullivan
authors.forename: C A
authors.initials: CA
authors.lastname: O'Morain
mesh_terms: D000328:Adult; D003109:Colonic Diseases, Functional / Q000382:microbiology* / Q000628:therapy*; D003967:Diarrhea / Q000209:etiology / Q000628:therapy; D004311:Double-Blind Method; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D007780:Lacticaseibacillus casei; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000627:therapeutic use*; D016896:Treatment Outcome