title: Evaluation of anti-tussive activity of Bergenia ciliata Sternb. rhizome extract in mice.
abstract: The methanol extract of the rhizome of Bergenia ciliata Sternb. (Saxifragaceae) has been evaluated for its potential in a cough model induced by sulphur dioxide gas in mice. The extract exhibited significant anti-tussive activity in a dose-dependent manner, as compared with control. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg body wt.), a standard anti-tussive agent. The extract at doses of 100, 200 and 300 mg/kg body wt. (p.o.) showed significant inhibition of cough reflex by 28.7, 33.9 and 44.2%, respectively, within 90 min of the experiment.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: T
authors.initials: T
authors.lastname: Murugesan
authors.forename: M
authors.initials: M
authors.lastname: Pal
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D019684:Magnoliopsida; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D018517:Plant Roots; D013458:Sulfur Dioxide
chemical_list: D000996:Antitussive Agents; D010936:Plant Extracts; D013458:Sulfur Dioxide