title: Proton MR spectroscopy in idiopathic spasmodic torticollis.
abstract: Single-voxel proton magnetic resonance spectroscopy (1H-MRS), localised to the basal ganglia, was used to determine changes in metabolite levels in idiopathic spasmodic torticollis (IST). We examined nine patients and 13 healthy subjects. The mean values (+/- SD) of peak area ratios were: IST: N-acetyl-aspartate (NAA)/choline-containing compounds (Cho) 1.79 +/- 0.39, NAA/creatine and phosphocreatine compounds (Cr) 1.61 +/- 0.38, Cho/Cr 0.91 +/- 0.19; controls: NAA/Cho 2.07 +/- 0.35, NAA/ Cr 1.82 +/- 0.31, Cho/Cr 0.89 +/- 0.12. Statistical analysis showed that NAA/Cho and NAA/Cr were significantly lower in patients than in controls (P = 0.0304 and 0.0431, respectively). These results indicate a reduction in NAA, and suggest striatal involvement in the pathogenesis IST.
authors.affiliation: Department of Neurology and Psychiatry, Bari, Italy. francescofederico@neurol.uniba.it
authors.forename: F
authors.initials: F
authors.lastname: Federico
authors.forename: V
authors.initials: V
authors.lastname: Lucivero
authors.forename: I L
authors.initials: IL
authors.lastname: Simone
authors.forename: G
authors.initials: G
authors.lastname: Defazio
authors.forename: R
authors.initials: R
authors.lastname: De Salvia
authors.forename: D M
authors.initials: DM
authors.lastname: Mezzapesa
authors.forename: M
authors.initials: M
authors.lastname: Petruzzellis
authors.forename: C
authors.initials: C
authors.lastname: Tortorella
authors.forename: P
authors.initials: P
authors.lastname: Livrea
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001479:Basal Ganglia / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D014103:Torticollis / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline