title: Comparison of animal models for the evaluation of radiolabeled androgens.
abstract: Biodistribution of two 18F-labeled androgens and an 124I/125I-labeled androgen were studied in five androgen receptor (prostate) animal models with or lacking sex hormone binding globulin (SHBG). As models for androgen-receptor positive ovarian cancer, xenografts of three human ovarian cancer cell lines were tested in SCID mice. SHBG in the prostate model systems significantly affects the metabolism, clearance, and distribution of the radiolabeled androgens in several tissues, but ovarian cancer animal models were disappointing.
authors.affiliation: Department of Chemistry, Washington University, St. Louis, MO, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Downer
authors.forename: L A
authors.initials: LA
authors.lastname: Jones
authors.forename: J A
authors.initials: JA
authors.lastname: Engelbach
authors.forename: L L
authors.initials: LL
authors.lastname: Lich
authors.forename: W
authors.initials: W
authors.lastname: Mao
authors.forename: K E
authors.initials: KE
authors.lastname: Carlson
authors.forename: J A
authors.initials: JA
authors.lastname: Katzenellenbogen
authors.forename: M J
authors.initials: MJ
authors.lastname: Welch
mesh_terms: D000728:Androgens / Q000493:pharmacokinetics*; D000818:Animals; D001345:Autoradiography; D006224:Cricetinae; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007553:Isotope Labeling; D008297:Male; D051379:Mice; D023421:Models, Animal; D010051:Ovarian Neoplasms / Q000378:metabolism*; D010215:Papio; D011471:Prostatic Neoplasms / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013045:Species Specificity; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
chemical_list: D000728:Androgens; D005462:Fluorine Radioisotopes; D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D012738:Sex Hormone-Binding Globulin; C063572:sex hormone-binding globulin receptor