title: Primary non-Hodgkin's lymphomas of the liver with nodular and diffuse infiltration patterns have different prognoses.
abstract: BACKGROUND
  Primary liver non-Hodgkin's lymphomas have peculiar clinical and biological patterns. This study correlates these patterns with pathology and outcome.
  
  
  METHODS
  Clinical records and histology of patients with primary liver non-Hodgkin's lymphoma, treated at our institution over a 20-year period, were reviewed. Lymphoproliferations occurring after liver transplantation were excluded. Survival analyses were performed with patients from the other published series (62 patients).
  
  
  RESULTS
  Our series included eight patients. Three patients had a nodular liver infiltration, corresponding to a large B-cell lymphoma. Five patients had a diffuse liver infiltration, of whom three had a T-cell lymphoma with predominant sinusoid infiltration, and two had a large B-cell lymphoma. Patients with diffuse liver infiltration presented with hepatomegaly, and two of these also had acute liver failure. Diffuse infiltration had a worse prognosis than nodular infiltration (P = 0.0033). Among these latter patients, those treated with an anthracycline-based chemotherapy had a better outcome (P < 0.0001).
  
  
  CONCLUSIONS
  Patients with primary liver lymphomas can be classified in two groups, depending on the type of infiltration. Those with nodular infiltration may benefit from anthracycline-based chemotherapy. Diffuse infiltration has a bad prognosis, and should be suspected in patients presenting with altered liver functions and hepatomegaly.
authors.affiliation: Service d'anatomie pathologique, Hôpital Paul Brousse, UPRES 1596 and IFR 89, Université Paris Sud, France. jean-francois.emile@pbr.ap-hop-paris.fr
authors.forename: J F
authors.initials: JF
authors.lastname: Emile
authors.forename: D
authors.initials: D
authors.lastname: Azoulay
authors.forename: J M
authors.initials: JM
authors.lastname: Gornet
authors.forename: G
authors.initials: G
authors.lastname: Lopes
authors.forename: V
authors.initials: V
authors.lastname: Delvart
authors.forename: D
authors.initials: D
authors.lastname: Samuel
authors.forename: M
authors.initials: M
authors.lastname: Reynès
authors.forename: H
authors.initials: H
authors.lastname: Bismuth
authors.forename: F
authors.initials: F
authors.lastname: Goldwasser
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000628:therapy; D016399:Lymphoma, T-Cell / Q000473:pathology; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome