title: Laser Doppler measurement of cochlear blood flow changes during conditioning noise exposure.
abstract: Using laser Doppler flowmetry, cochlear blood flow was assessed in Mongolian gerbils exposed to noise. Anesthetized animals were surgically implanted with permanent electrodes and then exposed for 10 consecutive days (6 h on/18 h off) to an octave band noise centered at 4 kHz (85 dB SPL). The auditory brainstem responses and the blood flow in the basal turn of the cochlea were compared with those of gerbils not exposed to noise. The exposed animals developed an initial threshold shift, followed by a progressive reduction in threshold shift up to complete recovery at the end of the test. In the exposed animals, a reduction in the cochlear blood flow during the first 4 days of exposure was observed, which was then followed by a progressive increase up to the end of the test. The results of this study exclude a possible role of the microvasculature of the lateral cochlear wall in determining the resistance to 4 kHz frequency noise exposure.
authors.affiliation: Institute of Otolaryngology, University La Sapienza Rome, Italy. giusatta@tiscalinet.it
authors.forename: G
authors.initials: G
authors.lastname: Attanasio
authors.forename: G
authors.initials: G
authors.lastname: Buongiorno
authors.forename: F
authors.initials: F
authors.lastname: Piccoli
authors.forename: B
authors.initials: B
authors.lastname: Mafera
authors.forename: A
authors.initials: A
authors.lastname: Cordier
authors.forename: M
authors.initials: M
authors.lastname: Barbara
authors.forename: R
authors.initials: R
authors.lastname: Filipo
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D003051:Cochlea / Q000098:blood supply* / Q000503:physiopathology; D003216:Conditioning, Operant; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005849:Gerbillinae; D006317:Hearing Loss, Noise-Induced / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation*; D009622:Noise / Q000009:adverse effects*; D012720:Severity of Illness Index