Carboplatin and oxaliplatin decomposition in chloride medium, monitored by XAS.
The stability of carboplatin and oxaliplatin aqueous solutions has been studied under different chloride ions concentration and pH conditions. For both compounds, we demonstrate the chloration of the platinum first coordination shell.
Curis
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E
Laboratoire de Biomathématique - Faculté de Pharmacie, Université Paris 5, France.
Provost
K
K
Bouvet
D
D
Nicolis
I
I
Crauste-Manciet
S
S
Brossard
D
D
Bénazeth
S
S
D000970:Antineoplastic Agents / Q000737:chemistry*; D016190:Carboplatin / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry; D004355:Drug Stability; D005583:Fourier Analysis; D006863:Hydrogen-Ion Concentration; D009944:Organoplatinum Compounds / Q000737:chemistry*; D000077150:Oxaliplatin; D012996:Solutions; D013052:Spectrometry, X-Ray Emission / Q000379:methods
D000970:Antineoplastic Agents; D002712:Chlorides; D009944:Organoplatinum Compounds; D012996:Solutions; D000077150:Oxaliplatin; D016190:Carboplatin; D002945:Cisplatin