title: Maternal kappa-containing IgG induces a late anti-Kappa response in adult, Kappa-deficient offspring.
abstract: Kappa (kappa)-light (L) chain-deficient (Ckappa-/-) mice readily mount a T cell-dependent antibody response after immunization with kappa-containing proteins. Such antibody responses areabsent in normal (Ckappa+/+) animals because of tolerance due to the abundance of kappa-L chains expressed on more than 95% of all B cells and serum immunoglobulins. When heterozygous kappa-sufficient (Ckappa+/-) females are bred with homozygous kappa-deficient (Ckappa-/-) males, half of their offspring will become kappa-deficient but have received kappa-L chain containing maternal Ig, mainly IgG and IgA, through placental and intestinal transmission. The kappa-containing maternal Ig persists for more than 2 months in the circulation of the offspring. Starting from week 15-20 of age, a spontaneous antibody response towards the maternal kappa-L chains can be recorded. The time of onset, as well as the magnitude of the responses differ among individuals of the same litter. Invariably, once a response has been initiated, it transits into an IgG-type of response, which upon injection with kappa-containing protein shows the features of a secondary type of immune response.
authors.affiliation: Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Bengtsson
authors.forename: A
authors.initials: A
authors.lastname: Daggfeldt
authors.forename: K O
authors.initials: KO
authors.lastname: Grönvik
authors.forename: J
authors.initials: J
authors.lastname: Andersson
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics* / Q000276:immunology*; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011247:Pregnancy
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains