title: Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein.
abstract: Two heptad repeat regions in the ectodomain of the human immunodeficiency virus type 1 (HIV-1) transmembrane subunit (gp41) self-assemble into a six-helix bundle structure that is critical for virus entry. Immunizations with peptides corresponding to these regions generated antibodies specific to the receptor-activated conformations of gp41.
authors.affiliation: Office of Vaccines, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland 20892-4555, USA.
authors.forename: E
authors.initials: E
authors.lastname: de Rosny
authors.forename: R
authors.initials: R
authors.lastname: Vassell
authors.forename: P T
authors.initials: PT
authors.lastname: Wingfield
authors.forename: C T
authors.initials: CT
authors.lastname: Wild
authors.forename: C D
authors.initials: CD
authors.lastname: Weiss
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015704:CD4 Antigens / Q000276:immunology*; D002461:Cell Line, Transformed; D015483:HIV Antibodies / Q000276:immunology*; D015700:HIV Envelope Protein gp41 / Q000737:chemistry / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000276:immunology*; D011487:Protein Conformation; D011817:Rabbits; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D015704:CD4 Antigens; D015483:HIV Antibodies; D015700:HIV Envelope Protein gp41; D010455:Peptides