title: Progression of impairment in patients with vascular cognitive impairment without dementia.
abstract: Little is known about progression, short of dementia, in vascular cognitive impairment. In the Canadian Study of Health and Aging, 149 participants (79.3 +/- 6.7 years; 61% women) were found to have vascular cognitive impairment, no dementia (CIND). After 5 years, 77 participants (52%) had died and 58 (46%) had developed dementia. Women were at greater risk of dementia (OR 2.1, 1.0 to 4.5). Of 32 participants alive without dementia, cognition had deteriorated in seven and improved in four. Half of those with vascular CIND developed dementia within 5 years, suggesting a target for preventive interventions.
authors.affiliation: Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Wentzel
authors.forename: K
authors.initials: K
authors.lastname: Rockwood
authors.forename: C
authors.initials: C
authors.lastname: MacKnight
authors.forename: V
authors.initials: V
authors.lastname: Hachinski
authors.forename: D B
authors.initials: DB
authors.lastname: Hogan
authors.forename: H
authors.initials: H
authors.lastname: Feldman
authors.forename: T
authors.initials: T
authors.lastname: Østbye
authors.forename: C
authors.initials: C
authors.lastname: Wolfson
authors.forename: S
authors.initials: S
authors.lastname: Gauthier
authors.forename: R
authors.initials: R
authors.lastname: Verreault
authors.forename: I
authors.initials: I
authors.lastname: McDowell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D015331:Cohort Studies; D016001:Confidence Intervals; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000523:psychology; D018450:Disease Progression; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009483:Neuropsychological Tests; D016017:Odds Ratio