title: [Intensive preoperative hypoxic radiotherapy in combined treatment of patients with cancer of the colon].
abstract: Efficacy of combined treatment (203 patients) and surgical treatment (200 patients) alone was analyzed. In combined treatment either radiation therapy (RT) in the dose 20 Gy over 5 days (group 1) or hypoxyradiotherapy (HRT) in the same doses but in combination with hypoxia (10% oxygen and 90% nitrogen--hypoxic gas mixture HGM-10--group 2) were used in preoperative period. In group 3 HGM-9 (9% oxygen and 91% nitrogen) was used as radioprotector in preoperative period but in increased by 25% radiation doses: total 25 Gy, 5 Gy for 5 days. In the control group only radical surgical treatment was performed. Preoperative irradiation didn't increase the rate of postoperative complications. At the same time the 5-year survival rate was higher in all the groups of patients on combined treatment than in the group of patients on surgical radical treatment. In the group with HGM-9 and increased by 25% radiation doses postoperative complications rate was lower, recurrences and distant metastases occurred less frequently.
authors.forename: V V
authors.initials: VV
authors.lastname: Prorokov
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Zalit
authors.forename: V I
authors.initials: VI
authors.lastname: Knysh
authors.forename: A I
authors.initials: AI
authors.lastname: Barkanov
authors.forename: V S
authors.initials: VS
authors.lastname: Anan'ev
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000601:surgery*; D000328:Adult; D003110:Colonic Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009584:Nitrogen; D010100:Oxygen; D011300:Preoperative Care; D011837:Radiation-Protective Agents; D011879:Radiotherapy Dosage; D013997:Time Factors
chemical_list: D011837:Radiation-Protective Agents; C041364:nitrox; D009584:Nitrogen; D010100:Oxygen
vernacular_title: Intensivnaia predoperatsionnaia gipoksiradioterapiia v kombinoravannom lechenii bol'nykhs rakom obodochnoĭ kishki.