title: Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine.
abstract: In a randomised, controlled, double-blinded trial to study the effect of ondansetron pretreatment on the pain produced after intravenous injection of rocuronium and propofol in comparison with lidocaine, 60 patients were randomly assigned to one of three groups. Group 1 received 5 ml of intravenous 0.9% sodium chloride solution pretreatment, group 2 received ondansetron 4 mg (2 mg.ml-1 solution) diluted into a 5-ml solution, and group 3 received 50 mg lidocaine (5 ml 1% solution); this was followed 1 min later by rocuronium and propofol. Pain was reduced significantly in the ondansetron and lidocaine groups (p < 0.0001) compared with placebo, and significantly better with lidocaine than with ondansetron (p = 0.02). We conclude that ondansetron is effective in relieving the pain of rocuronium but is not as effective as lidocaine.
authors.affiliation: Department of Anaesthesia, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074. mummadi@pacific.net.sg
authors.forename: M S
authors.initials: MS
authors.lastname: Reddy
authors.forename: F G
authors.initials: FG
authors.lastname: Chen
authors.forename: H P
authors.initials: HP
authors.lastname: Ng
mesh_terms: D000328:Adult; D000732:Androstanols / Q000009:adverse effects; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D007442:Intubation, Intratracheal; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects; D017294:Ondansetron / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement; D015742:Propofol / Q000009:adverse effects*; D000077123:Rocuronium; D012702:Serotonin Antagonists / Q000627:therapeutic use
chemical_list: D000732:Androstanols; D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D000932:Antiemetics; D003473:Neuromuscular Nondepolarizing Agents; D012702:Serotonin Antagonists; D017294:Ondansetron; D008012:Lidocaine; D000077123:Rocuronium; D015742:Propofol