[Morphological and functional markers of the histo-hematological barrier in experimental hypercholesterolemia].
Results of the experiments carried out have shown that in experimental hypercholesterinemia it is disordered microcirculation together with mediated changes in permeability of the histohematic barrier, lipoprotein-rich plasma in the pericapillar space, with the organ parenchyma trophicity getting compromised that are primarily responsible for the presence of dystrophy and fibrosis of organs. Unidirectionality and systemic pattern of the reaction is evidence of a generalized character of affections of the terminal vascular bed in response to exposure to one of the risk factors for atherogenesis, viz, exogenous cholesterin and dyslipidemia.
Kakauridze
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D000818:Animals; D001055:Apolipoproteins B / Q000097:blood; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology; D015415:Biomarkers; D001921:Brain / Q000098:blood supply; D002199:Capillary Permeability; D003331:Coronary Vessels / Q000473:pathology; D004036:Diet, Atherogenic; D005355:Fibrosis; D006937:Hypercholesterolemia / Q000150:complications / Q000473:pathology*; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D008099:Liver / Q000098:blood supply; D008168:Lung / Q000098:blood supply; D008833:Microcirculation / Q000473:pathology; D008854:Microscopy, Electron; D011817:Rabbits; D013997:Time Factors
D001055:Apolipoproteins B; D015415:Biomarkers
Morfofunktsional'nye pokazateli gistogematicheskogo bar'era pri eksperimental'noĭ giperkholesterinemii.