title: [Identification of specific features of the development of iodine deficiency in children exposed to low-intensity ecological factors (in case of the Perm Region)].
abstract: Iodine deficiency is an important sociomedical problem in most regions of Russia, including the Perm Region. In this connection, to study the low combined influence of a complex of natural (iodine deficiency) and man-made (aerogenic polluting components) factors on human health is urgent. Clinical and laboratory screenings of children were performed in 20 areas of the Perm Region, which have various anthropogenic loads. Varying iodine provision was established for the first time by urinary iodine values (median concentrations). There were characteristic manifestations of thyroid dysfunction in children and thyroid size alterations as hyperplasia. The blood levels of trace elements were measured in the children. There was a mutual interaction of excessive and deficient trace elements with the concentration of thyroid hormones and the level of ioduria. The study areas were classified by the indices reflecting iodine deficiency. The priority indices required for consideration in drawing up regional programmes for preventing and correcting iodine deficiency in the population were defined. Thus, the study have demonstrated that the factors of aerogenic load promote the aggravation of iodine deficiency in the children of the Perm Region, which should be born in mind in their prevention and correction.
authors.forename: N V
authors.initials: NV
authors.lastname: Zaĭtseva
authors.forename: M A
authors.initials: MA
authors.lastname: Zemlianova
authors.forename: D A
authors.initials: DA
authors.lastname: Kir'ianov
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004463:Ecology; D004787:Environmental Pollution / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D008297:Male; D012307:Risk Factors; D012424:Rural Population; D012426:Russia; D013963:Thyroid Hormones / Q000097:blood; D014131:Trace Elements / Q000097:blood; D014505:Urban Population
chemical_list: D013963:Thyroid Hormones; D014131:Trace Elements; D007455:Iodine
vernacular_title: Vyiavlenie osobennosteĭ formirovaniia ĭoddefitsitnykh sostoianiĭ u deteĭ v usloviiakh vozdeĭstviia ékologicheskikh faktorov maloĭ intensivnosti (na primere Permskoĭ oblasti).