title: Reperfusion demonstrated by apparent diffusion coefficient mapping after local intra-arterial thrombolysis for ischaemic stroke.
abstract: Diffusion-weighted MRI (DWI) is becoming important for diagnosis and investigation of acute cerebral ischaemia. It has been reported that apparent diffusion coefficient (ADC) maps could be an indicator of reperfusion. Our aim was to use echo-planar technology to investigate this phenomenon. We report 19 patients treated by local intra-arterial thrombolysis for middle cerebral artery stroke within 6 h of the onset of symptoms, in whom we performed follow-up DWI. ADC were found to be higher in the patients with angiographically proven reperfusion.
authors.affiliation: Department of Neuroradiology, Inselspital, University of Bern, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Taleb
authors.forename: K O
authors.initials: KO
authors.lastname: Lövblad
authors.forename: M
authors.initials: M
authors.lastname: El-Koussy
authors.forename: R
authors.initials: R
authors.lastname: Guzman
authors.forename: C
authors.initials: C
authors.lastname: Bassetti
authors.forename: M
authors.initials: M
authors.lastname: Arnold
authors.forename: H
authors.initials: H
authors.lastname: Oswald
authors.forename: L
authors.initials: L
authors.lastname: Remonda
authors.forename: G
authors.initials: G
authors.lastname: Schroth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002560:Cerebrovascular Circulation; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000627:therapeutic use; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator