title: Nitric oxide signaling mechanisms in the forearm vasculature of pregnant women.
abstract: During pregnancy, forearm blood flow and constrictor responses to nitric oxide synthase inhibition are enhanced. Responses to brachial artery infusion of N(G)-monomethyl-L -arginine in pregnant women who have normal resting forearm blood flow and in pregnant women who have norepinephrine-induced reduced forearm blood flow were no different. Mechanisms independent of acute flow effects may account for the enhanced vascular nitric oxide activity during pregnancy.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Newcastle upon Tyne, United Kingdom. D.O.C.Anumba@ncl.ac.uk
authors.forename: D O
authors.initials: DO
authors.lastname: Anumba
authors.forename: G A
authors.initials: GA
authors.lastname: Ford
authors.forename: S C
authors.initials: SC
authors.lastname: Robson
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D009638:Norepinephrine / Q000494:pharmacology; D011247:Pregnancy; D015398:Signal Transduction; D019323:omega-N-Methylarginine / Q000008:administration & dosage
chemical_list: D004791:Enzyme Inhibitors; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D009638:Norepinephrine