Expression of Golli mRNA during development in primary immune lymphoid organs of the rat.
The gene-of-the-oligodendrocyte lineage (Golli)-MBP transcription unit contains three Golli-specific exons together with eight exons of the "classical" myelin basic protein (MBP) gene, yielding alternatively spliced proteins which share amino acid sequence with MBP. Unlike MBP, a late antigen expressed only in the nervous system, Golli gene products are expressed pre- and post-natally at many sites. In this study, we determined the sequence of Golli in rat by RT-PCR and 5' RACE and showed that Golli sequences are expressed in primary lymphoid organs as early as e16.5, which could explain the anergic rat T cell response we previously observed in Golli-induced meningitis.
Skorupa
A F
AF
The Wistar Institute, Philadelphia, PA 19104, USA.
Brezinski
S C
SC
Lesh
G
G
Heber-Katz
E
E
McMorris
F A
FA
D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D001483:Base Sequence / Q000235:genetics; D004622:Embryo, Mammalian / Q000378:metabolism; D005260:Female; D007107:Immune System / Q000196:embryology*; D008221:Lymphoid Tissue / Q000196:embryology*; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D014157:Transcription Factors / Q000235:genetics*
C436006:Mbp protein, rat; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D014157:Transcription Factors