[Dynamics of markers and rheological properties of red blood cells in patients with hemorrhagic fever presenting with renal syndrome treated with trental and clivarin].
Hemorrhagic fever with the renal syndrome (HFRS) is a viral disease of zoonotic nature presenting with a polyorgan symptomatology, with the leading syndrome being essentially a hemorrhagic one. Studied in HFRS patients during different stages of treatment were morphological-and-functional features of erythocytes (E). As many as 65 HFRS patients presenting with varying degree severity of their trouble were examined. The control group comprised 15 subjects. E volume was studied together with content and concentration of hemoglobin (Hb) in one E. There have been estimated parameters characterizing aggregation (percentage of minimum/maximum aggregation, deaggregation factor, second wave of aggregation). Trental and clivarin were prescribed for the trouble. In severe and moderately severe course a decrease in Hb content and concentration in the early period was revealed as was an augmentation of E volume, with Hb level and hematocrit value tending to be on the increase. Changes in rheological parameters were manifested by higher percentage of minimum and maximum aggregation and decrement in the deaggregation factor by 55 percent as compared with the control group.
Ibragimova
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D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D015415:Biomarkers; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D018056:Hemorheology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000188:drug therapy; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*
D000925:Anticoagulants; D015415:Biomarkers; D005343:Fibrinolytic Agents; D006454:Hemoglobins; D006495:Heparin, Low-Molecular-Weight; C094240:reviparin; D010431:Pentoxifylline
Dinamika nekotorykh pokazateleĭ agregatsii i reologicheskikh svoĭstv eritrotsitov u bol'nykh gemorragicheskoĭ likhoradkoĭ s pochechnym sindromom na fone lecheniia trentalom i klivarinom.