Analgesic, diuretic, and anti-inflammatory principle from Scoparia dulcis.
Scoparinol, a diterpene, isolated from Scoparia dulcis showed significant analgesic (p < 0.001) and anti-inflammatory activity (p < 0.01) in animals. A sedative action of scoparinol was demonstrated by a marked potentiation of pentobarbital-induced sedation with a significant effect on both onset and duration of sleep (p < 0.05). Measurement of urine volume after administration of scoparinol indicated its significant diuretic action.
Ahmed
M
M
Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh. mua@du.bangla.net
Shikha
H A
HA
Sadhu
S K
SK
Rahman
M T
MT
Datta
B K
BK
D000465:Algorithms; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D001208:Asia; D002351:Carrageenan; D004232:Diuretics / Q000302:isolation & purification / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D020318:Rats, Long-Evans; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004232:Diuretics; D006993:Hypnotics and Sedatives; D002351:Carrageenan; D010424:Pentobarbital