title: Cutaneous necrobiotic xanthogranuloma (NXG)--successfully treated with low dose chlorambucil.
abstract: We report a case of necrobiotic xanthogranuloma in a 51 year-old white male patient presenting with a 6-year history of multiple indurated violaceous nodules and plaques involving the eyelids, trunk and extremities. He had an associated paraproteinemia (Ig G lambda), elevated sedimentation rate, cryoglobulinemia and hypocomplementemia. No extracutaneous involvement was detected. He was successfully treated with chlorambucil (2 mg/d for 7 months), leading to disappearance of all skin lesions.
authors.affiliation: Service of Dermatology, Hospital Geral Santo António, Rua D. Manuel II, Edifício ex: Cicap, 4099-001 Porto, Portugal. basleite@esoterica.pt
authors.forename: S
authors.initials: S
authors.lastname: Machado
authors.forename: R
authors.initials: R
authors.lastname: Alves
authors.forename: M
authors.initials: M
authors.lastname: Lima
authors.forename: I
authors.initials: I
authors.lastname: Leal
authors.forename: A
authors.initials: A
authors.lastname: Massa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D002699:Chlorambucil / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006099:Granuloma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D014973:Xanthomatosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil