Immunomodulatory effect of gold sodium thiomalate on murine acquired immunodeficiency syndrome.
Induction of IL-2 production and increased expression of CD25 were observed in C57BL/10 mice after weekly treatment with gold sodium thiomalate (GST). LP-BM5 murine leukemia virus (MuLV) infected mice treated with GST survived longer, had less cervical lymph node swelling, lower spleen weight, and fewer abnormalities in the expression of the cell surface markers, CD4, CD8a and CD45R/B220 on spleen cells than those that were not treated with GST. Thus, GST treatment may be beneficial through a decrease in disease progression via IL-2 induction in MuLV infected mice. This may have application in human immunodeficiency virus-infected individuals.
Yamaguchi
K
K
Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan. koushi@med.showa-u.ac.jp
Ushijima
H
H
Hisano
M
M
Inoue
Y
Y
Shimamura
T
T
Hirano
T
T
Müller
W E
WE
D000818:Animals; D004195:Disease Models, Animal; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage* / Q000276:immunology*; D007376:Interleukin-2 / Q000096:biosynthesis; D009052:Leukemia Virus, Murine / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology
D007376:Interleukin-2; D006052:Gold Sodium Thiomalate