title: Global cognitive decline in schizophrenia with remission of symptoms?
abstract: The relation of symptoms to cognitive dysfunction in schizophrenia is still controversial. This study was aimed (i) at verifying if a homogeneous sample of 10 young treated outpatients in remission from psychotic symptoms displays a characteristic pattern of cognitive dysfunction and (ii) at testing the issue of a general cognitive impairment. The neuropsychological performance of the patients was confronted with a large control group by means of Equivalent Scores, a normative method widely used in Italy, which allows direct, reliable comparison between tests and between patients. We found that our patients, as a group, were affected by a basic activation deficit in attention and by a semantic impairment. These deficits in symptom-free patients could indicate that their brains are in some ways working differently from those of normal controls and that this pattern is not necessarily linked to psychotic symptoms: their neuropsychological impairment might reflect a basic difference in the way of processing information that is always present and is independent of general intellectual decay.
authors.affiliation: Servizio di Neuropsicologia, Istituto Villa S. Ambrogio, Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Barbarotto
authors.forename: G
authors.initials: G
authors.lastname: Castignoli
authors.forename: C
authors.initials: C
authors.lastname: Pasetti
authors.forename: M
authors.initials: M
authors.lastname: Laiacona
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000209:etiology; D012075:Remission, Spontaneous; D012559:Schizophrenia / Q000150:complications* / Q000175:diagnosis; D012720:Severity of Illness Index