title: Fibrinolysis/proteolysis balance in stable angina pectoris in relation to angiographic findings.
abstract: The plasma fibrinolytic/proteolytic balance was assessed in 60 stable angina patients who underwent control coronary catheterization and the results were correlated with angiographic findings and control samples (n = 20). The concentrations of t-PA, PAI-1, collagenase (MMP-1), tissue inhibitor of MMP (TIMP-1), plasmin-antiplasmin (PAP) complexes and alpha2-macroglobulin (alpha2-M) were measured in plasma samples. The results showed a significant increase of PAP (p <0.001) and a reduction of alpha2-M (p <0.001) in the group of patients when compared to controls, indicating a degree of fibrinolysis/proteolysis activation. There was no correlation between the different parameters analyzed and the extent of angiographically proven atherosclerosis (one or more stenotic vessels), while the t-PA levels were significantly elevated (p <0.03) in patients with coronary stenosis > or =75% or occlusion. We conclude that there is a disturbance of the plasma fibrinolysis/proteolysis in patients with stable angina not related to the extent of atherosclerosis. The t-PA levels may be a good marker for coronary occlusion in these patients.
authors.affiliation: Atherosclerosis Research Unit, Division of Cardiovascular Pathophysiology and Biochemistry, University of Navarra, Pamplona, Spain. japaramo@unav.es
authors.forename: J A
authors.initials: JA
authors.lastname: Páramo
authors.forename: J
authors.initials: J
authors.lastname: Orbe
authors.forename: J
authors.initials: J
authors.lastname: Fernández
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000000981:diagnostic imaging; D000933:Antifibrinolytic Agents / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000097:blood; D001779:Blood Coagulation Factors / Q000032:analysis; D016022:Case-Control Studies; D017023:Coronary Angiography; D005260:Female; D005341:Fibrinolysin; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000097:blood / Q000502:physiology*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood; D000979:alpha-2-Antiplasmin; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D000933:Antifibrinolytic Agents; D015415:Biomarkers; D001779:Blood Coagulation Factors; D017395:Plasminogen Activator Inhibitor 1; D019715:Tissue Inhibitor of Metalloproteinase-1; D000979:alpha-2-Antiplasmin; D000511:alpha-Macroglobulins; C037742:plasmin-plasmin inhibitor complex; D010447:Peptide Hydrolases; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin; D020781:Matrix Metalloproteinase 1