CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease.
The pathogenesis of coronary arterial inflammation in acute Kawasaki disease (KD) is unclear. To test the hypothesis that the KD vascular lesion is an activated T lymphocyte-dependent process, immunohistochemical studies were done on coronary artery aneurysms from 8 fatal acute KD cases by using antibodies to CD45RO (activated or memory T lymphocyte), CD8 (cytotoxic T lymphocyte), CD4 (helper T lymphocyte), HAM56 (macrophage), and CD20 (B lymphocyte). Acute KD coronary arteritis was characterized by transmural infiltration of CD45RO T lymphocytes with CD8 T lymphocytes predominating over CD4 T lymphocytes. Macrophages were present primarily in the adventitial layer; B lymphocytes were notably absent. These data lend support to the hypotheses that KD results from infection with an intracellular pathogen, such as a virus, whose antigens are presented by major histocompatibility complex class I molecules, and that CD8 T lymphocytes and macrophages are important in the pathogenesis of KD coronary aneurysms.
Brown
T J
TJ
Department of Pediatrics, Northwestern University Medical School, and Children's Memorial Hospital, Chicago, Illinois 60611, USA.
Crawford
S E
SE
Cornwall
M L
ML
Garcia
F
F
Shulman
S T
ST
Rowley
A H
AH
D018951:Antigens, CD20 / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000150:complications / Q000276:immunology*; D003331:Coronary Vessels / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D017493:Leukocyte Common Antigens / Q000032:analysis; D008264:Macrophages / Q000276:immunology*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000276:immunology*
D018951:Antigens, CD20; D016827:CD8 Antigens; D017493:Leukocyte Common Antigens