Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA.
Quantitative in situ hybridization on rat coronal brain sections with radiolabelled oligonucleotide probes was performed to investigate the effects of antipsychotic drugs on mRNA levels of regulator of G-protein signalling (RGS) 2 and c-fos. This study demonstrated a similar increase of RGS2 mRNA level in the striatum upon both a single and a 21-day treatment with either haloperidol (2 mg/kg) or risperidone (7.5 mg/kg) in contrast to clozapine (20 mg/kg). Otherwise, the acute c-fos mRNA induction in the striatum was abolished by 74 to 89% upon chronic treatment with either haloperidol or risperidone. In conclusion, the induction of RGS2 mRNA in the striatum, in contrast to the immediate early gene c-fos mRNA, is preserved upon chronic treatment with haloperidol and risperidone.
Robinet
E A
EA
Centre de Recherche Pierre Fabre, Department of Cellular & Molecular Biology, 17 avenue Jean Moulin, 81106 Castres Cédex, France.
Geurts
M
M
Maloteaux
J M
JM
Pauwels
P J
PJ
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology; D004334:Drug Administration Schedule; D019204:GTP-Binding Proteins / Q000187:drug effects / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology; D017403:In Situ Hybridization; D008297:Male; D017072:Neostriatum / Q000187:drug effects* / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D020710:RGS Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018967:Risperidone / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D015854:Up-Regulation / Q000187:drug effects* / Q000235:genetics
D014150:Antipsychotic Agents; D016760:Proto-Oncogene Proteins c-fos; D020710:RGS Proteins; D012333:RNA, Messenger; C105345:Rgs2 protein, mouse; D019204:GTP-Binding Proteins; D003024:Clozapine; D006220:Haloperidol; D018967:Risperidone