title: Bioavailable testosterone as a correlate of cognition, psychological status, quality of life, and sexual function in aging males: implications for testosterone replacement therapy.
abstract: Andropause is a syndrome described in aging males, is composed of a constellation of physical, sexual, and emotional symptoms, and is thought to be related to declining concentrations of serum testosterone. Numerous studies of testosterone replacement therapy in elderly hypogonadal males have documented the physical benefits of such treatment, but have failed to assess cognition, psychological functioning, and quality of life. Male outpatients greater or equal to 55 years of age completed cognitive, psychological, sexual, and quality of life assessments. A serum sample was provided for bioavailable testosterone assay. The associations between bioavailable testosterone concentrations and neuropsychological testing were assessed using Spearman rank correlation. Overall, bioavailable testosterone was not an important determinant of cognitive, psychological, or sexual functioning or of quality of life. The implications for future studies involving testosterone replacement therapy are discussed.
authors.affiliation: Clinical and Administrative Pharmacy Division, College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA. paul-perry@uiowa.edu
authors.forename: P J
authors.initials: PJ
authors.lastname: Perry
authors.forename: B C
authors.initials: BC
authors.lastname: Lund
authors.forename: S
authors.initials: S
authors.lastname: Arndt
authors.forename: T
authors.initials: T
authors.lastname: Holman
authors.forename: K A
authors.initials: KA
authors.lastname: Bever-Stille
authors.forename: J
authors.initials: J
authors.lastname: Paulsen
authors.forename: L M
authors.initials: LM
authors.lastname: Demers
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D001682:Biological Availability; D003071:Cognition / Q000187:drug effects*; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D008875:Middle Aged; D011788:Quality of Life; D012725:Sexual Behavior / Q000523:psychology*; D013739:Testosterone / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D013739:Testosterone