Antihyperglycaemic effect of Diamed, a herbal formulation, in experimental diabetes in rats.
Diamed is a herbal formulation composed of the aqueous extracts of three medicinal plants (Azardirachta indica, Cassia auriculata and Momordica charantia). We have investigated Diamed for its possible antihyperglycaemic action in rats with alloxan-induced experimental diabetes. Oral administration of Diamed (1.39 (0.25 g), 1.67 (0.30 g) or 1.94 (0.35 g) mL kg(-1)) for 30 days resulted in a significant reduction in blood glucose, glycosylated haemoglobin, and an increase in plasma insulin and total haemoglobin. The effect was highly significant after administration of the 1.94 mL (0.35 g) g(-1) body weight dose. Diamed also prevented a decrease in body weight. An oral glucose tolerance test was performed in experimental diabetic rats in which there was a significant improvement in glucose tolerance in the animals treated with Diamed. The effect was compared with 600 microg kg(-1) glibenclamide. The results showed that Diamed had antihyperglycaemic action in experimental diabetes in rats.
Pari
L
L
Department of Biochemistry, Annamalai University, Tamil Nadu, India. paribala@sancharnet.in
Ramakrishnan
R
R
Venkateswaran
S
S
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D028321:Plant Preparations