title: Polydipsia, psychosis, and familial psychopathology.
abstract: OBJECTIVE
  To compare the demographic and clinical factors and familial psychopathology of chronic psychiatric inpatients with, and without, polydipsia.
  
  
  METHODS
  We undertook a case-control study of chronic psychiatric inpatients both with, and without, polydipsia. Clinical and demographic data were gathered using a predesigned questionnaire, the Positive and Negative Syndrome Scale (PANSS), the Abnormal Involuntary Movement Scale (AIMS), the Mini-Mental State Examination Scale (MMSE), and the Family History-Research Diagnostic Criteria (FH-RDC).
  
  
  RESULTS
  The prevalence rate of polydipsia was 20.2%. The group with polydipsia was significantly younger, both at the time of their first-ever psychiatric and current psychiatric admissions, compared with the group without polydipsia. The 2 groups were similar in terms of their illness characteristics and psychiatric diagnoses. In the group with polydipsia, alcohol abuse predated the psychotic illness by a mean of 10.5 (SD 4.4) years, compared with 4.8 (SD 1.6) years for the same period in the unaffected group. The 2 groups did not differ significantly regarding the antipsychotic medication dosage, the proportion on concomitant anticholinergic medication, the documented previous response to antipsychotic medication, or past treatment with electroconvulsive therapy (ECT). First-degree relatives of patients with polydipsia were found to have significantly higher rates of alcohol dependence.
  
  
  CONCLUSIONS
  This study provides further evidence for the higher rate of polydipsia among chronic psychiatric patient populations and for high rates of alcohol-related problems among their first-degree relatives.
authors.affiliation: University of Ottawa, Royal Ottawa Health Care Group, Brockville Campus, Brockville, Ontario. vkahmed@hotmail.com
authors.forename: A G
authors.initials: AG
authors.lastname: Ahmed
authors.forename: L M
authors.initials: LM
authors.lastname: Heigh
authors.forename: K V
authors.initials: KV
authors.lastname: Ramachandran
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics / Q000523:psychology; D016022:Case-Control Studies; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D004359:Drug Therapy, Combination; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects; D012306:Risk; D014869:Water Intoxication / Q000235:genetics* / Q000523:psychology
chemical_list: D011619:Psychotropic Drugs