title: Adult-to-adult live donor liver transplantation: a short-term clinicopathologic study.
abstract: With the success of pediatric live donor liver transplantation (LDLT) and the continued shortage of cadaveric donors, adult-to-adult LDLT has been performed at some centers, including ours. We performed a detailed histologic review of all liver specimens obtained from 9 adult recipients at and after LDLT and correlated these findings with the patients' course and outcome. Five patients had histologic evidence of biliary tract pathology; 3 of 5 required surgical or radiologic intervention. The other 2 had clinically insignificant biliary disease. Diffuse hepatocytic hemorrhagic necrosis secondary to massive portal blood flow after portal venous revascularization resulted in graft failure and retransplantation in a single patient with severe preoperative portal hypertension. Two perioperative deaths were caused by sepsis and multiorgan failure (day 25) and generalized thrombosis related to factor V Leiden (day 6). The preoperative diagnosis, presence of portal vein thrombosis in the native liver, postoperative cholangiopathy, and subcapsular hemorrhagic necrosis in donor liver wedge biopsies did not affect the short-term outcome. In conclusion, biliary tract pathology is common after adult-to-adult LDLT but does not negatively affect graft or patient survival. Infrequent but catastrophic vascular complications related to portal hemodynamics or thrombosis can result in graft loss and/or patient death.
authors.affiliation: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors.forename: G
authors.initials: G
authors.lastname: Ayata
authors.forename: E
authors.initials: E
authors.lastname: Pomfret
authors.forename: J J
authors.initials: JJ
authors.lastname: Pomposelli
authors.forename: F D
authors.initials: FD
authors.lastname: Gordon
authors.forename: W D
authors.initials: WD
authors.lastname: Lewis
authors.forename: R L
authors.initials: RL
authors.lastname: Jenkins
authors.forename: U
authors.initials: U
authors.lastname: Khettry
mesh_terms: D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000473:pathology / Q000503:physiopathology; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D008099:Liver / Q000473:pathology / Q000502:physiology / Q000601:surgery*; D008103:Liver Cirrhosis / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods* / Q000502:physiology; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016896:Treatment Outcome