title: Rapid improvement of osteomalacia by treatment in a case with Sjögren's syndrome, rheumatoid arthritis and renal tubular acidosis type 1.
abstract: We present here a case of Sjögren's syndrome (SjS) with osteomalacia based on renal tubular acidosis type 1 (RTA-1). A 53-year-old woman, diagnosed as having rheumatoid arthritis (RA) at the age of 33, was admitted to our hospital because of sicca complex, fatigability and worsening general aching. The activity of RA had been low, but it was complicated by SjS, RTA-1 and remarkable osteomalacia. Acidosis was corrected by alkali supplement therapy. By treatment with a regimen consisting of alfacalcidol, calcium L-aspartate, elcatonin and ipriflavone, her bone mineral density (BMD) was remarkably improved within months and the generalized aching gradually diminished.
authors.affiliation: First Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama.
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Hidaka
authors.forename: T
authors.initials: T
authors.lastname: Shinohara
authors.forename: K
authors.initials: K
authors.lastname: Kataharada
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: F
authors.initials: F
authors.lastname: Ohsuzu
mesh_terms: D000141:Acidosis, Renal Tubular / Q000188:drug therapy* / Q000209:etiology; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D015519:Bone Density; D002116:Calcitonin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017610:Calcium Compounds / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D007529:Isoflavones / Q000627:therapeutic use; D008875:Middle Aged; D010018:Osteomalacia / Q000175:diagnosis* / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000700:Analgesics; D017610:Calcium Compounds; D006887:Hydroxycholecalciferols; D007529:Isoflavones; C018986:ipriflavone; D002116:Calcitonin; C008088:alfacalcidol; C012755:elcatonin