Two phenanthraquinones from Dendrobium moniliforme.
Two phenanthraquinones were isolated from the stems of Dendrobium moniliforme. They were identified by interpretation of spectral data as 2,6-dimethoxy-1,4,5,8-phenanthradiquinone and 5-hydroxy-3,7-dimethoxy-1,4-phenanthraquinone, named moniliformin (1) and denbinobin (2), respectively. This is the first report of compound 1, which possesses a novel 1,4,5,8-diquinone moiety in the phenanthraquinone skeleton. Compound 2 showed potent antiinflammatory effects in vitro.
Lin
T H
TH
Institute of Chinese Pharmaceutical Sciences, China Medical College, 91, Hsueh-Shih Road, Taichung 404, Taiwan, Republic of China.
Chang
S J
SJ
Chen
C C
CC
Wang
J P
JP
Tsao
L T
LT
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001202:Ascitic Fluid / Q000166:cytology; D002478:Cells, Cultured / Q000187:drug effects; D002855:Chromatography, Thin Layer; D015232:Dinoprostone / Q000032:analysis / Q000037:antagonists & inhibitors; D005966:Glucuronidase / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D007371:Interferon-gamma; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008407:Mast Cells / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000032:analysis; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification*; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011796:Quinacrine / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013624:Taiwan; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000037:antagonists & inhibitors
D000880:Anthraquinones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D010616:Phenanthrenes; D014409:Tumor Necrosis Factor-alpha; C436544:denbinobin; C436543:plant product, moniliformin; D009569:Nitric Oxide; D006632:Histamine; D007371:Interferon-gamma; D005966:Glucuronidase; D011796:Quinacrine; D015232:Dinoprostone