A novel modified pterin from a Eudistoma species ascidian.
The MeOH extract of an Indonesia Eudistoma sp. ascidian contained 1,3,O(7)-trimethylisoxanthopterin (1), a novel pteridine. The purification of 1 was achieved through flash C(18) chromatography and cyano HPLC. The structure was determined primarily through the use of (1)H-(13)C and (1)H-(15)N HMBC measurements and comparison with data obtained for 1,3,7-trimethylguanine (2).
Van Wagoner
R M
RM
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Jompa
J
J
Tahir
A
A
Ireland
C M
CM
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006147:Guanine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011622:Pterins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014561:Urochordata / Q000737:chemistry*
C436784:1,3,7-trimethylguanine; C436785:1,3,O(7)-trimethylisoxanthopterin; D011622:Pterins; D006147:Guanine