Biotransformation of malachite green by the fungus Cunninghamella elegans.
The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 micromol x h(-1) (mg of cells)(-1). Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cytochrome P450 system mediated both the reduction and the N-demethylation reactions.
Cha
C J
CJ
Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.
Doerge
D R
DR
Cerniglia
C E
CE
D001673:Biodegradation, Environmental; D004396:Coloring Agents / Q000737:chemistry / Q000378:metabolism*; D003470:Culture Media; D020093:Cunninghamella / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D012394:Rosaniline Dyes / Q000737:chemistry / Q000378:metabolism*
D004396:Coloring Agents; D003470:Culture Media; D012394:Rosaniline Dyes; C005095:malachite green; D003577:Cytochrome P-450 Enzyme System