title: Discrepancy between inducibility of ventricular tachycardia and activity of cardiac sarcoidosis. Requirement of defibrillator implantation for the inactive stage of cardiac sarcoidosis.
abstract: Monomorphic ventricular tachycardia (VT) developed in two patients with cardiac sarcoidosis. Before treatment with prednisolone, technetium or gallium scintigram revealed abnormal accumulation in the heart and bilateral hilar lymph nodes, but programmed electrical stimulation failed to induce VT in either case. Prednisolone was administered and the abnormal accumulation of the scintigra ms disappeared. However, VT became reproducibly inducible, and in one of the patients, transient entrainment was demonstrated in clinical VT morphology. Defibrillators were implanted in both patients. Some VTs associated with cardiac sarcoidosis are due to reentry, and inducibility of VT is not associated with the activity of cardiac sarcoidosis. Even though steroid therapy suppresses the activity of cardiac sarcoidosis, defibrillator implantation is necessary to prevent a possible arrhythmic event during the follow-up.
authors.affiliation: First Department of Internal Medicine, Niigata University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Mezaki
authors.forename: M
authors.initials: M
authors.lastname: Chinushi
authors.forename: T
authors.initials: T
authors.lastname: Washizuka
authors.forename: H
authors.initials: H
authors.lastname: Furushima
authors.forename: Y
authors.initials: Y
authors.lastname: Chinushi
authors.forename: K
authors.initials: K
authors.lastname: Ebe
authors.forename: H
authors.initials: H
authors.lastname: Okumura
authors.forename: Y
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002304:Cardiac Pacing, Artificial; D009202:Cardiomyopathies / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D017147:Defibrillators, Implantable; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D015203:Reproducibility of Results; D012507:Sarcoidosis / Q000150:complications* / Q000503:physiopathology; D017180:Tachycardia, Ventricular / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D011239:Prednisolone