title: Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in cord blood lipids of full-term infants.
abstract: BACKGROUND
  Previous studies showed significant inverse correlations between values of trans isomeric and long-chain polyunsaturated fatty acids in plasma lipids of preterm infants and healthy children aged 1-15 y.
  
  
  OBJECTIVE
  We sought to evaluate the same correlations in full-term infants at birth.
  
  
  METHODS
  We studied healthy full-term infants (n = 42) born after normal pregnancies and deliveries. All infants had a family history of atopy (both parents or one of the parents and a sibling had atopic symptoms). The fatty acid composition of venous cord blood lipids was determined by high-resolution capillary gas-liquid chromatography.
  
  
  RESULTS
  The mean (+/-SEM) sum of trans fatty acids was 0.49 +/- 0.02% by wt in phospholipids, 2.47 +/- 0.20% by wt in cholesterol esters, 1.73 +/- 0.09% by wt in triacylglycerols, and 1.59 +/- 0.07% by wt in nonesterified fatty acids. Linear correlation analysis showed significant inverse correlations between the sum of trans fatty acids and both arachidonic acid and docosahexaenoic acid in phospholipids (r = -0.56, P < 0.001, and r = -0.48, P = 0.01, respectively), cholesterol esters (r = -0.52, P < 0.001, and r = -0.39, P = 0.018, respectively), and nonesterified fatty acids (r = -0.41, P = 0.007, and r = -0.41, P = 0.006, respectively).
  
  
  CONCLUSIONS
  Because trans fatty acids in the fetal circulation must originate from the maternal diet, our results indicate that maternal exposure to trans fatty acids may represent a previously neglected variable that inversely influences long-chain polyunsaturated fatty acid status in full-term infants at birth.
authors.affiliation: Department of Paediatrics, University of Pécs, Pécs, Hungary. decsi@apacs.pote.hu
authors.forename: T
authors.initials: T
authors.lastname: Decsi
authors.forename: I
authors.initials: I
authors.lastname: Burus
authors.forename: S
authors.initials: S
authors.lastname: Molnár
authors.forename: H
authors.initials: H
authors.lastname: Minda
authors.forename: V
authors.initials: V
authors.lastname: Veitl
mesh_terms: D002788:Cholesterol Esters / Q000097:blood / Q000737:chemistry; D002849:Chromatography, Gas; D015525:Fatty Acids, Omega-3 / Q000097:blood; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000097:blood* / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007536:Isomerism; D008297:Male; D008431:Maternal-Fetal Exchange; D009747:Nutritional Physiological Phenomena; D010743:Phospholipids / Q000097:blood / Q000737:chemistry; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood / Q000737:chemistry
chemical_list: D002788:Cholesterol Esters; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D010743:Phospholipids; D014280:Triglycerides