title: The prognostic importance of c-myc oncogene expression in head and neck melanoma.
abstract: Melanomas of the head and neck have a poorer prognosis than melanomas arising at other cutaneous sites. To study the biology of this disease, the expression of the c-myc oncogene was studied in tumors from 97 patients with head and neck melanoma using the technique of flow cytometry. Survival analysis revealed that stratification of patients according to oncogene expression provided a prognostic marker with shorter overall survival in tumors with high nuclear c-myc oncoprotein positivity (log-rank test, chi2 = 8.77, p < 0.005). Multifactorial analysis using Cox's proportional hazards model revealed nuclear c-myc oncoprotein to be an independent prognostic marker (log-rank test, chi2 = 8.82, p = 0.005). These results support the authors' previous studies of the prognostic value of c-myc expression in melanoma and suggest that estimation of c-myc oncoprotein may be of clinical importance in identifying high-risk patients.
authors.affiliation: RAFT Institute of Plastic Surgery, Mt Vernon Hospital, Northwood, Middlesex, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Chana
authors.forename: R
authors.initials: R
authors.lastname: Grover
authors.forename: G D
authors.initials: GD
authors.lastname: Wilson
authors.forename: D A
authors.initials: DA
authors.lastname: Hudson
authors.forename: M
authors.initials: M
authors.lastname: Forders
authors.forename: R
authors.initials: R
authors.lastname: Sanders
authors.forename: A O
authors.initials: AO
authors.lastname: Grobbelaar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005434:Flow Cytometry; D015870:Gene Expression; D016259:Genes, myc / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012878:Skin Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate