title: Synthesis of OSW-1 analogues and a dimer and their antitumor activities.
abstract: Five analogues, including a 16-epi-isomer (6), and a 3-terephthalic acid linked dimer (8) of OSW-1 were synthesized. Their inhibitory activities on P388 and A-549 cells were detected.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032, Shanghai, China.
authors.forename: X
authors.initials: X
authors.lastname: Ma
authors.forename: B
authors.initials: B
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Hui
authors.forename: Z
authors.initials: Z
authors.lastname: Miao
authors.forename: J
authors.initials: J
authors.lastname: Ding
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002783:Cholestenones; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388; D051379:Mice; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002783:Cholestenones; D012503:Saponins; C106408:OSW 1