title: Spatial summation of heat pain in males and females.
abstract: Sex differences in pain sensitivity have been found to vary between considerable and negligible. It has appeared that the pain stimulation method is critical in this context. It was assumed this might be due to the different degrees of spatial summation associated with the different pain stimulus modalities. Hence, sex differences were investigated in spatial summation of heat pain in 20 healthy women and 20 healthy men of similar age. Pain thresholds were assessed by a tracking procedure and responses to supra-threshold pain stimulation by numerical ratings. Heat stimuli were administered by a thermode with contact areas of 1, 3, 6 and 10 cm2. Pain thresholds were significantly higher with smaller areas stimulated than with larger ones. No significant effect of area was found for the ratings of the supra-threshold stimuli, the intensities of which were tailored to the individual pain threshold. Consequently, spatial summation of heat pain appeared to result mainly in a shift of the pain threshold on the ordinate and not a change of slope of the stimulus-response function in the pain range. In neither of the two pain parameters were there any sex differences. Therefore, the present study demonstrated that sex differences in spatial summation of heat pain are unlikely.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Marburg, Germany. leutenba@post.med.uni-marburg.de
authors.forename: S
authors.initials: S
authors.lastname: Lautenbacher
authors.forename: J
authors.initials: J
authors.lastname: Nielsen
authors.forename: T
authors.initials: T
authors.lastname: Andersen
authors.forename: L
authors.initials: L
authors.lastname: Arendt-Nielsen
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D009619:Nociceptors / Q000502:physiology; D017288:Pain Threshold / Q000502:physiology*; D012737:Sex Factors; D012867:Skin / Q000294:innervation; D012881:Skin Temperature / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*