A synthetic strategy for the cyclodepsipeptide core of the antitumor antibiotic verucopeptin.
[reaction: see text]. An efficient [2 + 2 + 2]-fragment condensation strategy is described for obtaining the cyclodepsipeptide core of verucopeptin. The 19-membered macrocycle was established through a Carpino HATU mediated macrolactamization, which proceeded in good yield under high-dilution conditions.
Hale
K J
KJ
The Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom. k.j.hale@ucl.ac.uk
Lazarides
L
L
Cai
J
J
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D047630:Depsipeptides; D010455:Peptides / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; D010455:Peptides; D010456:Peptides, Cyclic; C082424:verucopeptin