title: Single nucleotide polymorphisms and recombination rate in humans.
abstract: Levels of heterozygosity for single nucleotide polymorphisms vary by more than one order of magnitude in different regions of the human genome. Regional differences in the rate of recombination explain a substantial fraction of the variation in levels of nucleotide polymorphism, consistent with the widespread action of natural selection at the molecular level.
authors.affiliation: Dept of Ecology and Evolutionary Biology, University of Arizona, Tuscon 85721, USA. nachmann@email.arizona.edu
authors.forename: M W
authors.initials: MW
authors.lastname: Nachman
mesh_terms: D019143:Evolution, Molecular; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D016678:Genome; D006579:Heterozygote; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D020161:Physical Chromosome Mapping; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic; D014960:X Chromosome / Q000235:genetics*
chemical_list: D005819:Genetic Markers