Cholestane glycosides from the bulbs of Galtonia candicans and their cytotoxicity.
Further search for cytotoxic compounds contained in the bulbs of Galtonia candicans (Liliaceae) led to the isolation of four potent cytotoxic cholestane glycosides (1-4) based upon 3beta,16beta,17alpha-trihydroxycholest-5-en-22-one, three of which (2-4) have not been reported previously. A new cholestane bisdesmoside (5) and a new rearranged cholestane glycoside (6) were also isolated. The structural assignment of the new constituents was carried out by spectroscopic analysis and a few chemical transformations.
Kuroda
M
M
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan.
Mimaki
Y
Y
Yokosuka
A
A
Sashida
Y
Y
D002776:Cholestanes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D019668:Liliaceae / Q000737:chemistry / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018514:Plant Structures / Q000737:chemistry / Q000633:toxicity
D002776:Cholestanes; D003603:Cytotoxins; D006027:Glycosides; D010936:Plant Extracts