title: Clinical evaluation of acellular allograft dermis for the treatment of human gingival recession.
abstract: BACKGROUND
  Periodontal root coverage procedures to treat recession areas are indicated for unesthetic, exposed, and/or painful root surfaces. Many methods, most using autogenous soft tissue grafts, have been utilized, but with associated morbidity at the donor sites. An alternative donor material would reduce the morbidity and provide for sufficient available donor tissue.
  
  
  METHODS
  An acellular allogeneic dermal connective tissue matrix (AD) and autogenous palatal connective tissue (CT) were compared as subepithelial grafts for the treatment of gingival recession. Twenty-two patients with similar isolated gingival recession of > or = 2 mm on 2 separate teeth were treated with the subepithelial graft technique. Exposed roots were hand root planed only and, by random allocation, either a fitted AD or fitted CT graft was secured in place and covered by coronally positioned flaps.
  
  
  RESULTS
  Mann Whitney U test analysis found the following changes at 6 months for AD and CT, respectively, compared to presurgical conditions: root coverage of 1.7 +/- 1.2 (65.9%) and 2.2 +/- 1.1 mm (74.1%) (both P<0.01), increase in keratinized tissue (KT) of 1.2 +/- 1.3 and 1.6 +/- 1.9 (both P<0.01), and an increase in gingival thickness with both; 83.2% of expected root coverage was obtained with AD and 88.6% with CT (P= 0.43). There were no significant differences between treatments for any parameter. Global assessments by clinicians and patients suggested a more esthetic clinical result with AD.
  
  
  CONCLUSIONS
  These results suggest that acellular allogeneic dermal matrix may be a useful substitute for autogenous connective tissue grafts in root coverage procedures.
authors.affiliation: Periodontics Department, Louisiana State University School of Dentistry, New Orleans 70119-2799, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Aichelmann-Reidy
authors.forename: R A
authors.initials: RA
authors.lastname: Yukna
authors.forename: G H
authors.initials: GH
authors.lastname: Evans
authors.forename: H F
authors.initials: HF
authors.lastname: Nasr
authors.forename: E T
authors.initials: ET
authors.lastname: Mayer
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D003238:Connective Tissue / Q000637:transplantation; D004846:Epithelial Attachment / Q000502:physiology; D005260:Female; D005889:Gingival Recession / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019647:Oral Surgical Procedures; D017060:Patient Satisfaction; D017768:Skin, Artificial; D018709:Statistics, Nonparametric; D016896:Treatment Outcome