title: Structure-activity relationship studies of isoquinolinone type anticancer agent.
abstract: Substituted isoquinolin-1-ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-N-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.
authors.affiliation: College of Pharmacy, Chonnam National University, Kwangju, Korea. shcheon@chonnam.ac.kr
authors.forename: S H
authors.initials: SH
authors.lastname: Cheon
authors.forename: J S
authors.initials: JS
authors.lastname: Park
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
authors.forename: Y N
authors.initials: YN
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Yi
authors.forename: B H
authors.initials: BH
authors.lastname: Chung
authors.forename: B G
authors.initials: BG
authors.lastname: Choi
authors.forename: W J
authors.initials: WJ
authors.lastname: Cho
authors.forename: S U
authors.initials: SU
authors.lastname: Choi
authors.forename: C O
authors.initials: CO
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D007546:Isoquinolines