title: Effects of inhaled salbutamol in exercising non-asthmatic athletes.
abstract: BACKGROUND
  Beta-2 agonists such as salbutamol are used, not only by asthmatic athletes to prevent exercise induced asthma, but also by non-asthmatic athletes as a potentially ergogenic agent. We have investigated whether inhaled salbutamol enhances endurance performance in non-asthmatic athletes.
  
  
  METHODS
  A prospective double blind, randomised, three way crossover design was used to study the effects of 200 microg and 800 microg inhaled salbutamol versus a placebo in 12 trained triathletes. The treatments were compared in three identical cycle ergometer sessions at 85% of the predetermined maximal oxygen uptake. Lung function, endurance time, metabolic parameters (glucose, potassium, lactate, free fatty acid, and glycerol), and psychomotor performance were evaluated.
  
  
  RESULTS
  Neither endurance time nor post-exercise bronchodilation were significantly different between the treatments. Metabolic parameters were affected by exercise but not by treatment.
  
  
  CONCLUSIONS
  Inhaled salbutamol, even in a high dose, did not have a significant effect on endurance performance in non-asthmatic athletes, although the bronchodilating effect of the drug at the beginning of exercise may have improved respiratory adaptation. Our results do not preclude an ergogenic effect of beta2 agonists given by other routes or for a longer period.
authors.affiliation: Service d'Explorations Fonctionnelles, Physiologie Respiratoire et de l'Exercice, CHU de Poitiers, 86021 Poitiers, France.
authors.forename: C
authors.initials: C
authors.lastname: Goubault
authors.forename: M C
authors.initials: MC
authors.lastname: Perault
authors.forename: E
authors.initials: E
authors.lastname: Leleu
authors.forename: S
authors.initials: S
authors.lastname: Bouquet
authors.forename: P
authors.initials: P
authors.lastname: Legros
authors.forename: B
authors.initials: B
authors.lastname: Vandel
authors.forename: A
authors.initials: A
authors.lastname: Denjean
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D006801:Humans; D010101:Oxygen Consumption / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects; D011446:Prospective Studies; D012129:Respiratory Function Tests; D013177:Sports / Q000502:physiology*
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol