title: Occurrence of ventricular late potentials in patients with active acromegaly.
abstract: OBJECTIVE
  Patients with acromegaly have an increased risk of ventricular dysrhythmias and sudden death. Late potentials in a signal-averaged electrocardiogram (SAECG), a predictor of ventricular dysrhythmias, are frequently seen in patients after previous myocardial infarction, but little is known about the prevalence of late potentials in acromegaly. The aim of our study was to investigate the prevalence of late potentials in patients with acromegaly and their relation to the activity of the disease and to myocardial hypertrophy.
  
  
  METHODS
  The study included 48 patients with acromegaly [27 males, 21 females, mean age 52.3 +/- 14.2 years, 16 active disease, 32 cured or 'well controlled', under treatment with sandostatin analogues (12/32)] and 38 healthy volunteers as a control group.
  
  
  RESULTS
  Late potentials were detected in 9/16 (56%) patients with active acromegaly vs. 2/32 (6%) with cured/well controlled acromegaly (P = 0.001), defined as normal age-related IGF-1 levels and GH levels suppressible below 1 microg/l after an oral glucose load (75 g). Late potentials were not related to muscle mass index (127 +/- 35 active vs. 123 +/- 34 g/m2 cured/well controlled). The association of disease activity with the detection of late potentials was independent of age, gender, duration of the disease and body mass index. In comparison to the control group, the prevalence of late potentials was significantly higher in patients with acromegaly (23%) than in the control group (0%; P < 0.001).
  
  
  CONCLUSIONS
  Late potentials in the SAECG are frequently seen in active acromegaly and may represent an early and sensitive parameter to detect myocardial injury in acromegaly.
authors.affiliation: Division of Endocrinology, University of Essen, Germany. burkhard.herrmann@uni-essen.de
authors.forename: B L
authors.initials: BL
authors.lastname: Herrmann
authors.forename: C
authors.initials: C
authors.lastname: Bruch
authors.forename: B
authors.initials: B
authors.lastname: Saller
authors.forename: S
authors.initials: S
authors.lastname: Ferdin
authors.forename: N
authors.initials: N
authors.lastname: Dagres
authors.forename: C
authors.initials: C
authors.lastname: Ose
authors.forename: R
authors.initials: R
authors.lastname: Erbel
authors.forename: K
authors.initials: K
authors.lastname: Mann
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004452:Echocardiography; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D018754:Ventricular Dysfunction / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology