title: Once-a-day individualized amikacin dosing for suspected infection at birth based on population pharmacokinetic models.
abstract: Amikacin is widely used in the treatment of suspected or confirmed neonatal infections. However, dosage regimens are not well defined in this group of patients because of a wide inter-individual pharmacokinetic variability. An individualized goal-oriented amikacin dosage design was applied using population pharmacokinetic data. A dosing chart was developed for neonates during the first 2 days of life, by using population pharmacokinetic parameter values and USCPACK software. This dosing chart based on gestational age (GA) and body weight gives a once-a-day amikacin dosage regimen involving an injection every 24 h. Validation was performed in 57 neonates less than 2 days old, divided into three GA groups and prospectively treated using the dosing chart. Target peak serum levels of amikacin were obtained in 62-80% of patients after the first dose and in 80-100% after the second dose, and trough concentrations were obtained in 100%. This study has confirmed the need for individualization of amikacin dosage regimens in neonates.
authors.affiliation: Department of Neonatology, Debrousse Hospital, Cl. Bernard University, Lyon, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Labaune
authors.forename: N
authors.initials: N
authors.lastname: Bleyzac
authors.forename: P
authors.initials: P
authors.lastname: Maire
authors.forename: R W
authors.initials: RW
authors.lastname: Jelliffe
authors.forename: M J
authors.initials: MJ
authors.lastname: Boutroy
authors.forename: G
authors.initials: G
authors.lastname: Aulagner
authors.forename: G
authors.initials: G
authors.lastname: Putet
mesh_terms: D000583:Amikacin / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D001835:Body Weight; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007668:Kidney / Q000254:growth & development
chemical_list: D000583:Amikacin