[Heterochronic effects of neurotrophic factors in neurochemical organization of learning and memory in the adult organism].
Following elaboration of long-term habituation to a startle-response, antibodies to neurotrophic factor protein S100b exerted selective and dose-dependent influence on different learning processes and memory of learned behavioural patterns in adult rats. S100b increased at all stages of behavioural skill development in hippocampus, hypothalamus, frontal cortex, cerebellar hemispheres and vermis, basal ganglia.
Sherstnev
V V
VV
P. K. Anokhin Research Institute of Normal Physiology, Russian Acad. Med. Sci., 103009, Moscow, B. Nikitskaya, 6, Russia.
Gruden'
M A
MA
Storozheva
Z I
ZI
Proshin
A T
AT
D000161:Acoustic Stimulation; D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D003213:Conditioning, Psychological / Q000187:drug effects; D007858:Learning; D037102:Lectins / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008568:Memory; D009414:Nerve Growth Factors / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000187:drug effects; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins
D000906:Antibodies; D002135:Calcium-Binding Proteins; D037102:Lectins; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579158:S100b protein, rat; C059525:cerebellar soluble lectin
Geterokhronia uchastiia neĭrotroficheskikh faktorov v neĭrokhimicheskoĭ organizatsii protsessov obucheniia i pamiati v zrelom organizme.