Motile organelles: the importance of specific tubulin isoforms.
The requirements for building flagellar axonemes and centrioles are beginning to be uncovered. The carboxyl terminus of a specific beta tubulin isoform plays an important role in forming the '9 + 2' structure of the axoneme; delta tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.
Dutcher
S K
SK
Department of Genetics, Washington University School of Medicine, 660 s. Euclid, St. Louis, Missouri 63110, USA. dutcher@genetics.wuustl.edu
D000595:Amino Acid Sequence; D002502:Centrioles / Q000502:physiology*; D002923:Cilia / Q000502:physiology*; D008961:Models, Structural; D020409:Molecular Motor Proteins / Q000502:physiology; D008969:Molecular Sequence Data; D009068:Movement / Q000502:physiology*; D015388:Organelles / Q000502:physiology*; D020033:Protein Isoforms / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism*
D020409:Molecular Motor Proteins; D020033:Protein Isoforms; D014404:Tubulin