title: Use of a protocol to minimize hypersensitivity reactions with asparaginase administration.
abstract: Several antineoplastic drugs in clinical use may cause hypersensitivity reactions (HSRs) that range from an occasional individual reaction to a significant HSR. Asparaginase preparations have a high incidence of invoking HSRs. The use of an HSR protocol may minimize symptoms experienced by the patient and ensure rapid implementation of life-saving measures when reactions occur. The article will define HSRs, review occurrences, and include a protocol developed to minimize reactions to asparaginase preparations.
authors.forename: R
authors.initials: R
authors.lastname: Bryant
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001215:Asparaginase / Q000009:adverse effects*; D015400:Clinical Nursing Research; D002985:Clinical Protocols; D003663:Decision Trees; D004342:Drug Hypersensitivity / Q000145:classification / Q000209:etiology* / Q000451:nursing / Q000517:prevention & control*; D016903:Drug Monitoring / Q000379:methods / Q000451:nursing; D006801:Humans; D009730:Nursing Assessment / Q000379:methods; D009859:Oncology Nursing / Q000379:methods; D010347:Patient Care Planning / Q000458:organization & administration*
chemical_list: D000970:Antineoplastic Agents; D001215:Asparaginase