title: MR spectroscopy detection of lactate and lipid signals in the brains of healthy elderly people.
abstract: Magnetic resonance spectroscopy was used to assess the presence of brain lactate and lipid signals, frequently associated with the presence of pathology, in healthy persons of 60-90 years old (n = 540). Lactate and lipid signals were observed in, respectively, 25 and 6% of women, and 18 and 2% of men. Upon adjustment for age, and for MRI-detected cerebral atrophy and white matter lesions, the gender differences in lactate and lipid remained the same (p = 0.05 and p = 0.03, respectively). Brain lactate and lipid signals appear to be intrinsic to aging. However, the presence of these metabolites in very focal areas only, rather than in any distributed fashion within the brain (the latter generally the case with cerebral atrophy and white matter lesions), strongly suggests the existence of asymptomatic focal pathology not shown on MRI.
authors.affiliation: Department of Radiology, University Hospital Groningen, The Netherlands. p.e.sijens@rad.azg.nl
authors.forename: P E
authors.initials: PE
authors.lastname: Sijens
authors.forename: T
authors.initials: T
authors.lastname: den Heijer
authors.forename: F E
authors.initials: FE
authors.lastname: de Leeuw
authors.forename: J C
authors.initials: JC
authors.lastname: de Groot
authors.forename: E
authors.initials: E
authors.lastname: Achten
authors.forename: R J
authors.initials: RJ
authors.lastname: Heijboer
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: M M
authors.initials: MM
authors.lastname: Breteler
authors.forename: M
authors.initials: M
authors.lastname: Oudkerk
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D001284:Atrophy; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000032:analysis*; D008055:Lipids / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D012727:Sex Characteristics
chemical_list: D008055:Lipids; D019344:Lactic Acid