Comparison of animal models for the evaluation of radiolabeled androgens.
Biodistribution of two 18F-labeled androgens and an 124I/125I-labeled androgen were studied in five androgen receptor (prostate) animal models with or lacking sex hormone binding globulin (SHBG). As models for androgen-receptor positive ovarian cancer, xenografts of three human ovarian cancer cell lines were tested in SCID mice. SHBG in the prostate model systems significantly affects the metabolism, clearance, and distribution of the radiolabeled androgens in several tissues, but ovarian cancer animal models were disappointing.
Downer
J B
JB
Department of Chemistry, Washington University, St. Louis, MO, USA.
Jones
L A
LA
Engelbach
J A
JA
Lich
L L
LL
Mao
W
W
Carlson
K E
KE
Katzenellenbogen
J A
JA
Welch
M J
MJ
D000728:Androgens / Q000493:pharmacokinetics*; D000818:Animals; D001345:Autoradiography; D006224:Cricetinae; D005260:Female; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007553:Isotope Labeling; D008297:Male; D051379:Mice; D023421:Models, Animal; D010051:Ovarian Neoplasms / Q000378:metabolism*; D010215:Papio; D011471:Prostatic Neoplasms / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013045:Species Specificity; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D000728:Androgens; D005462:Fluorine Radioisotopes; D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D012738:Sex Hormone-Binding Globulin; C063572:sex hormone-binding globulin receptor