Acute disseminated encephalomyelitis following aseptic meningoencephalitis.
A previously healthy 50-year-old man developed aseptic meningoencephalitis with clinical manifestations including fever, headache, seizure, Wernicke aphasia, right hemiplegia, and blindness in the left eye. One and one-half months after remission of meningoencephalitis, marked ataxia and psychiatric symptoms became apparent. Magnetic resonance imaging revealed multiple new lesions involving the basal ganglia, thalamus, white matter, and cerebellum. Despite these developments, cerebrospinal fluid findings continued to improve except for excessive content of myelin basic protein. Within 2 weeks, steroid therapy dramatically resolved the ataxic symptoms and disseminated lesions.
Shintani
S
S
Department of Neurology, Toride Kyodo General Hospital, 2-1-1 Hongoh, Toride City, 302-0022, Ibaraki, Japan. dw4s-sntn@asahi-net.or.jp
Fumimura
Y
Y
Shiigai
T
T
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004673:Encephalomyelitis, Acute Disseminated / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008582:Meningitis, Aseptic / Q000150:complications* / Q000473:pathology; D008590:Meningoencephalitis / Q000150:complications* / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone