title: A synthetic strategy for the cyclodepsipeptide core of the antitumor antibiotic verucopeptin.
abstract: [reaction: see text]. An efficient [2 + 2 + 2]-fragment condensation strategy is described for obtaining the cyclodepsipeptide core of verucopeptin. The 19-membered macrocycle was established through a Carpino HATU mediated macrolactamization, which proceeded in good yield under high-dilution conditions.
authors.affiliation: The Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom. k.j.hale@ucl.ac.uk
authors.forename: K J
authors.initials: KJ
authors.lastname: Hale
authors.forename: L
authors.initials: L
authors.lastname: Lazarides
authors.forename: J
authors.initials: J
authors.lastname: Cai
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D047630:Depsipeptides; D010455:Peptides / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; D010455:Peptides; D010456:Peptides, Cyclic; C082424:verucopeptin