title: Comparison of initial distribution volume of glucose and plasma volume in thoracic fluid-accumulated patients.
abstract: OBJECTIVE
  We have reported that initial distribution volume of glucose indicates the central extracellular fluid volume in the presence of fluid gain or loss. The purpose of this study was to describe changes in initial distribution volume of glucose, plasma volume determined by the indocyanine green dilution method (PV-ICG), and thoracic fluid content by thoracic electrical bioimpedance in patients with or without apparent thoracic fluid accumulation in the absence of pleural effusion. We also sought to test whether initial distribution volume of glucose rather than PV-ICG mirrors thoracic fluid content.
  
  
  METHODS
  Prospective, clinical study.
  
  
  METHODS
  General intensive care unit.
  
  
  METHODS
  Eleven consecutive patients with apparent thoracic fluid accumulation as judged by thoracic fluid content >0.05/ohm and underlying pathology and 20 consecutive acute myocardial infarction patients within 24 hrs after its onset were selected for study. None of the acute myocardial infarction patients had thoracic fluid content >0.05/ohm.
  
  
  METHODS
  Five grams of glucose and 25 mg of indocyanine green were administered simultaneously to calculate initial distribution volume of glucose and PV-ICG daily for the fluid-accumulated patients, and the same dosages were administered to the acute myocardial infarction patients immediately after their admission to the intensive care unit after percutaneous coronary angioplasty. Only the data on the day of the maximal and minimal thoracic fluid content in the fluid-accumulated patients were used for the study. The relationship between these two fluid volumes and thoracic fluid content was evaluated in the two patient groups.
  
  
  RESULTS
  Initial distribution volume of glucose and thoracic fluid content rather than PV-ICG and thoracic fluid content moved together in the same direction in each fluid-accumulated patient. Neither pulmonary artery occlusion pressure, central venous pressure, nor PV-ICG produced a better correlation with cardiac index when compared with initial distribution volume of glucose in patients with or without thoracic fluid accumulation.
  
  
  CONCLUSIONS
  We suggest that initial distribution volume of glucose rather than PV-ICG is a better indicator of the intrathoracic blood volume status, even although intravenously administered glucose cannot stay in the intravascular compartment.
authors.affiliation: Department of Anesthesiology, University of Hirosaki School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan. ishihara@cc.hirosaki-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ishihara
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Okawa
authors.forename: T
authors.initials: T
authors.lastname: Ebina
authors.forename: T
authors.initials: T
authors.lastname: Tsubo
authors.forename: A
authors.initials: A
authors.lastname: Matsuki
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D001786:Blood Glucose; D017097:Electric Impedance; D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000493:pharmacokinetics*; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism*; D010953:Plasma Volume; D011175:Positive-Pressure Respiration; D011446:Prospective Studies; D011654:Pulmonary Edema / Q000378:metabolism*; D012131:Respiratory Insufficiency / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D001786:Blood Glucose; D007208:Indocyanine Green; D005947:Glucose