Increased 6-sulfatoxymelatonin excretion in women with polycystic ovary syndrome.
OBJECTIVE
To determine melatonin production in hyperandrogenic women.


METHODS
Controlled prospective study.


METHODS
Outpatients in an academic medical center.


METHODS
Twenty-two women with polycystic ovary syndrome (PCOS), 20 women with idiopathic hirsutism, and 15 age-matched individuals who had similar body mass indexes as controls.


METHODS
Fasting blood samples and 24-hour urinary samples were obtained from all participants.


METHODS
All participants provided serum samples for the measurement of LH, FSH, testosterone, E(2), DHEAS, 17 alpha-hydroxyprogesterone (17-OHP), and insulin levels, as well as urinary 6-sulfatoxymelatonin (aMT6s).


RESULTS
Women with PCOS had higher aMT6s, testosterone, LH/FSH ratio, and insulin values than either women with idiopathic hirsutism or control women. Testosterone inversely correlated with aMT6s in PCOS. Regression analysis revealed that only testosterone was an important determinant of aMT6s in PCOS.


CONCLUSIONS
Women with PCOS have increased melatonin production.
Luboshitzky
R
R
Endocrine Institute, Haemek Medical Center, Afula, Israel.
Qupti
G
G
Ishay
A
A
Shen-Orr
Z
Z
Futerman
B
B
Linn
S
S
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000652:urine; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006628:Hirsutism / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D006801:Humans; D007328:Insulin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008550:Melatonin / Q000031:analogs & derivatives / Q000652:urine*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D011374:Progesterone / Q000031:analogs & derivatives / Q000097:blood; D012016:Reference Values; D012044:Regression Analysis; D013739:Testosterone / Q000097:blood
D015415:Biomarkers; D007328:Insulin; C054513:6-sulfatoxymelatonin; C002175:progesterone 17 alpha-hydroperoxide; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008550:Melatonin