title: The value of b required to avoid T2 shine-through from old lucunar infarcts in diffusion-weighted imaging.
abstract: Multiple small infarcts of different ages are common in small-vessel disease. Diffusion-weighted imaging (DWI) is a powerful method for discriminating new from chronic lesions. This can be done on the diffusion-weighted images provided that b is sufficiently high. Our purpose was to determine that critical value of b. We reviewed DWI from a previous study of acute, mainly lacunar strokes, and selected 18 old lacunar infarcts, well defined on uncoded images with b 0 s/m2 (i. e., T2-weighted images) but invisible on DWI with b 1,200 x 10(6) s/m2. We used a 1.5 tesla imager and single-shot echo-planar technique. We had seven separate acquisitions with echo time 123 ms and b in steps between 0 and 1,200 x 10(6) s/m2. Two neuroradiologists blinded to the selection of lesions carried out two different lesion-detection procedures, thereby testing each lesion four times, giving a total of 72 tests of b values. The results were consistent, indicating a level for detection of 800 x 10(6) s/m2 in two tests, 400-600 x 10(6) s/m2 in 65 tests and at lower values in the remainder. For imagers up to 1.5 tesla, at long repetition times and an echo time up to 120 ms T2-shine through of old lacunar infarcts can be avoided using b of 1,000 x 10(6) s/m2.
authors.affiliation: Department of Radiology, University Hospital, Lund, Sweden. bo.geijer@drad.lu.se
authors.forename: B
authors.initials: B
authors.lastname: Geijer
authors.forename: P C
authors.initials: PC
authors.lastname: Sundgren
authors.forename: A
authors.initials: A
authors.lastname: Lindgren
authors.forename: S
authors.initials: S
authors.lastname: Brockstedt
authors.forename: F
authors.initials: F
authors.lastname: Ståhlberg
authors.forename: S
authors.initials: S
authors.lastname: Holtås
mesh_terms: D001921:Brain / Q000473:pathology; D020520:Brain Infarction / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011786:Quality Control; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted