title: [Study of the antiviral activity, pharmacokinetics and toxic properties of liposomal form of human alpha-2b interferon administered topically].
abstract: Human liposomal recombinant alpha 2b-interferon topically applied to laboratory animals was tested for antiviral activity, pharmacokinetics, and toxicity. The interferon was shown to penetrate through the skin and to circulate in the blood of experimental animals longer than its injectable form, and to exhibit its antiviral activity against genital herpes in guinea pigs. It produced no toxic, skin-irritant, or allergic effects in laboratory animals.
authors.forename: V V
authors.initials: VV
authors.lastname: Zolin
authors.forename: O A
authors.initials: OA
authors.lastname: Agafonova
authors.forename: A A
authors.initials: AA
authors.lastname: Kolokol'tsov
authors.forename: E D
authors.initials: ED
authors.lastname: Danilenko
authors.forename: L K
authors.initials: LK
authors.lastname: Fedosova
authors.forename: S G
authors.initials: SG
authors.lastname: Gamaleĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Omigov
authors.forename: V A
authors.initials: VA
authors.lastname: Fadina
authors.forename: V I
authors.initials: VI
authors.lastname: Masycheva
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D002478:Cells, Cultured / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D008081:Liposomes; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins; D012869:Skin Absorption
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008081:Liposomes; D011994:Recombinant Proteins
vernacular_title: Izuchenie protivovirusnoĭ aktivnosti, farmakokinetiki i toksicheskikh svoĭstv liposomal'noĭ formy rekombinantnogo alfa-2b-interferona cheloveka pri naruzhnom primenenii.