title: Infection and establishment of latency in the dog brain after direct inoculation of a nonpathogenic strain of herpes simplex virus-1.
abstract: A number of diseases affecting the CNS occur in the dog and can be used as models for gene therapy in a large brain. HSV-1 has several potential advantages as a vector to transfer genes into the CNS. However, the ability of HSV-1 to infect CNS cells varies among species and no information was available for the dog. When the nonpathogenic 1716 strain of HSV-1 was injected into the brains of normal dogs it established a latent infection without signs of pathology. Thus, it appears to be suitable as a vector for therapeutic, or marker genes, in this species.
authors.affiliation: Department of Pathobiology and Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Springer
authors.forename: C H
authors.initials: CH
authors.lastname: Vite
authors.forename: A C
authors.initials: AC
authors.lastname: Polesky
authors.forename: S
authors.initials: S
authors.lastname: Kesari
authors.forename: N W
authors.initials: NW
authors.lastname: Fraser
authors.forename: J H
authors.initials: JH
authors.lastname: Wolfe
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000821:virology; D004195:Disease Models, Animal; D004285:Dogs; D020803:Encephalitis, Herpes Simplex / Q000473:pathology / Q000821:virology*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D018259:Herpesvirus 1, Human / Q000235:genetics* / Q000472:pathogenicity*; D008297:Male; D014774:Virulence