title: Continual replacement of newly-generated olfactory neurons in adult rats.
abstract: It has been known that stem cells do exist in the central nervous system, and adult neurogenesis is continually taking place in the olfactory bulb during life. We report here, with the combined method of autoradiography using (3)H-thymidine and immunohistochemistry for a neuronal marker, that 65.3-76.9% of calretinin-immunoreactive bulbar neurons are replaced during the short period of 6 weeks in the adult rodent. The results indicate that neuronal replacement is a common phenomenon in the olfactory bulb during life.
authors.affiliation: Department of Anatomy, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Yokouchi
authors.forename: N
authors.initials: N
authors.lastname: Fukushima
authors.forename: K
authors.initials: K
authors.lastname: Kawagishi
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Moriizumi
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001345:Autoradiography; D002452:Cell Count; D016923:Cell Death / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D005260:Female; D007150:Immunohistochemistry; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar / Q000033:anatomy & histology / Q000254:growth & development* / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D013936:Thymidine / Q000493:pharmacokinetics; D014316:Tritium / Q000493:pharmacokinetics
chemical_list: D014316:Tritium; D013936:Thymidine