Haloperiodol-induced microcatalepsy differs in CD-1, BALB/c, and C57BL/6 mice.
The degree of arrest of movement (microcatalepsy) induced by haloperidol at doses equipotent for operant rate suppression was measured with computerized instrumentation. The inbred C57BL/6 mouse strain displayed more susceptibility to microcatalepsy than the CD-1 and BALB/c strains. In addition, the C57BL/6 strain exhibited a greater degree of sensitization to repeated dosing than did the other 2 strains. The results were consistent with the C57BL/6 mouse's hypodopaminergic profile reported in the literature but were at odds with results reported for conventional catalepsy testing. The C57BL/6 mouse may serve as a model for genetic vulnerability to extrapyramidal motor side effects and may be useful in quantifying the mild extrapyramidal motor side effects of atypical antipsychotic drugs.
Fowler
S C
SC
Department of Human Development, Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence 66045, USA. fowler@falcon.cc.ukans.edu
Zarcone
T J
TJ
Vorontsova
E
E
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced* / Q000523:psychology; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009042:Motivation; D018727:Muscarinic Antagonists / Q000494:pharmacology; D013045:Species Specificity; D014282:Trihexyphenidyl / Q000494:pharmacology
D014150:Antipsychotic Agents; D018727:Muscarinic Antagonists; D014282:Trihexyphenidyl; D006220:Haloperidol