title: Neurofibromatosis type 1 presenting with hand dystonia.
abstract: Neurofibromatosis type 1 is frequently associated with increased intensity T2-weighted magnetic resonance imaging (MRI) brain abnormalities, called "unidentified bright objects." Unidentified bright objects are generally held to be benign and tend to decrease in size during adulthood. We describe a case of neurofibromatosis type 1 with a similar thalamic and subthalamic MRI abnormality associated with contralateral hand dystonia. Over a 2-year follow-up, the lesions showed a reduction in size apparently correlated with a reduction in symptoms.
authors.affiliation: Department of Neurology, Bambino Gesù Children's Hospital, National Medical Research Institute, Rome, Italy. dicapua@opbg.net
authors.forename: M
authors.initials: M
authors.lastname: Di Capua
authors.forename: M L
authors.initials: ML
authors.lastname: Lispi
authors.forename: A
authors.initials: A
authors.lastname: Giannotti
authors.forename: D
authors.initials: D
authors.lastname: Longo
authors.forename: G
authors.initials: G
authors.lastname: Fariello
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D004421:Dystonia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006225:Hand / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009456:Neurofibromatosis 1 / Q000150:complications / Q000175:diagnosis*