title: [Estimate the safety of baculovirus insecticides: the history and the status Quo].
abstract: This article reviews the evaluation of security of baculovirus used as a pesticide. Since 1970s, the scholars have done a lot of experiments with kinds of baculovirus to test the security of a large number kinds of living things even our human beings. Almost all experiments proved that baculovirus is secure, but some experiments came to different conclusions. These gave rise to great debate twice when they were published, but these conclusions have been proved to be wrong with later test by other scientists or the author himself. Since 90s baculovirus have been used a great deal as the vector to express the foreign gene. Some of them reported the expression in mammalian cells, which brought the suspicious of the baculovirus safety. This article made an analysis and a conclusion about them. Also, this article laid emphasis on the security of recombination baculovirus with the results of the security experiment of self-made recombination baculovirus pesticide. In the last analysis, this article draws a conclusion that the baculovirus and recombinant baculovirus insecticides are secure.
authors.affiliation: Institute of Virology, Wuhan University, Wuhan 430072, China.
authors.forename: H Z
authors.initials: HZ
authors.lastname: Xiao
authors.forename: Y P
authors.initials: YP
authors.lastname: Qi
authors.forename: F H
authors.initials: FH
authors.lastname: Yang
mesh_terms: D000818:Animals; D016367:Baculoviridae / Q000472:pathogenicity*; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D010572:Pest Control, Biological; D011995:Recombination, Genetic
chemical_list: D007306:Insecticides