Excretory-secretory antigens of Trypanosoma cruzi are potentially useful for serodiagnosis of chronic Chagas' disease.
The reactivities of sera from chronic chagasic patients against the trypomastigote excreted-secreted antigens (TESA) of Trypanosoma cruzi strains with different biodemes were analyzed by TESA-blot and TESA-enzyme-linked immunosorbent assay (ELISA). Although both tests presented high sensitivity and specificity, TESA-ELISA is more appropriate for screening a larger number of samples.
Nakazawa
M
M
Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães/FIOCRUZ, Hospital Universitário Oswaldo Cruz/UPE, CEP 50670-420 Recife-PE, Brazil.
Rosa
D S
DS
Pereira
V R
VR
Moura
M O
MO
Furtado
V C
VC
Souza
W V
WV
Barros
M N
MN
Abath
F G
FG
Gomes
Y M
YM
D000818:Animals; D000953:Antigens, Protozoan / Q000097:blood*; D014355:Chagas Disease / Q000175:diagnosis* / Q000469:parasitology*; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D006168:Guinea Pigs; D006801:Humans; D015151:Immunoblotting; D012698:Serologic Tests; D014349:Trypanosoma cruzi / Q000276:immunology*
D000953:Antigens, Protozoan