Nonandrogenic mediators of prostatic growth.
Prostate growth and development are primarily under the control of androgens; however, other factors can also influence prostatic growth through alternative pathways. This article discusses some of the major nonandrogenic mediators of prostate growth. Information on the pathways by which these factors exert their effects is also reviewed.
Konety
B R
BR
Department of Urology, University of Pittsburgh, Pennsylvania 15213, USA. konetybr@msx.upmc.edu
Nelson
J B
JB
D001078:APUD Cells / Q000473:pathology; D000230:Adenocarcinoma / Q000378:metabolism; D000728:Androgens; D000818:Animals; D001839:Bombesin / Q000378:metabolism; D018288:Carcinoma, Small Cell / Q000473:pathology; D002877:Chromosomes, Human / Q000235:genetics; D016207:Cytokines / Q000502:physiology; D019332:Endothelin-1 / Q000502:physiology; D004815:Epidermal Growth Factor / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology; D006133:Growth Substances / Q000145:classification / Q000494:pharmacology / Q000502:physiology*; D006728:Hormones / Q000502:physiology; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000502:physiology; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism; D009928:Organ Specificity; D011467:Prostate / Q000254:growth & development* / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology*; D018125:Receptors, Transforming Growth Factor beta / Q000502:physiology; D013002:Somatomedins / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D000728:Androgens; D016207:Cytokines; D019332:Endothelin-1; D006133:Growth Substances; D006728:Hormones; D018969:Insulin-Like Growth Factor Binding Proteins; D017468:Receptors, Fibroblast Growth Factor; D017978:Receptors, Growth Factor; D018125:Receptors, Transforming Growth Factor beta; D013002:Somatomedins; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D001839:Bombesin