title: Vinyl sulfonium as novel proteolytic enzyme inhibitor.
abstract: Vinyl sulfoniums were synthesized from vinyl sulfides by methylation, and inhibited the proteolytic enzyme papain. Inhibition studies suggest a mechanism by which the vinyl sulfonium inhibitor covalently and irreversibly modifies the enzyme.
authors.affiliation: Department of Chemistry and School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4630, USA.
authors.forename: G
authors.initials: G
authors.lastname: Zhao
authors.forename: Z S
authors.initials: ZS
authors.lastname: Zhou
mesh_terms: D001586:Benzoylarginine Nitroanilide / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D010206:Papain / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013452:Sulfonium Compounds / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D015853:Cysteine Proteinase Inhibitors; D013440:Sulfides; D013452:Sulfonium Compounds; D014753:Vinyl Compounds; C442384:methylphenylvinyl sulfonium; D001586:Benzoylarginine Nitroanilide; D010206:Papain