title: Plasma antioxidant capacity of HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit-vegetable-concentrate containing antioxidant polyphenols.
abstract: OBJECTIVE
  To investigate whether antioxidant polyphenols from fruit juices or a fruit-vegetable-concentrate increase the plasma antioxidant capacity in HIV-infected and healthy subjects.
  
  
  METHODS
  Twenty-three HIV-seropositive and 18 seronegative adults were randomized to ingest either 1 l of fruit juice or 30 ml fruit-vegetable-concentrate per day over 16 weeks in addition to their normal Western diet.
  
  
  METHODS
  Plasma antioxidant capacity was determined as Trolox equivalent antioxidant capacity (TEAC) at baseline, after 1 and 16 weeks of intervention, and after a 6 week washout.
  
  
  RESULTS
  There was no difference in plasma antioxidant capacity between HIV-infected and healthy subjects at baseline (P=0.1). After 16 weeks of intervention TEAC increased in HIV-positive subjects with both types of polyphenol supplementation (juice, 1.38+/-0.07 to 1.42+/-0.04 mM, P=0.034; concentrate, 1.40+/-0.09 to 1.46+/-0.08 mM, P=0.025). TEAC was not altered by either type of supplementation in HIV-seronegative subjects.
  
  
  CONCLUSIONS
  Plasma antioxidant capacity can be increased by long-term ingestion of polyphenols from fruit juices or fruit-vegetable-concentrate in HIV-seropositive but not in HIV-seronegative subjects.
  
  
  BACKGROUND
  This study was supported by a grant and Cellagon aurum from HG Berner GmbH, Altenholz, and fruit juices from Eckes Granini GmbH & Co. KG, Nieder-Olm.
authors.affiliation: School of Medicine, Department of Hemostasis and Transfusion Medicine, University of Düsseldorf, Düsseldorf, Germany.
authors.forename: B M
authors.initials: BM
authors.lastname: Arendt
authors.forename: A M
authors.initials: AM
authors.lastname: Boetzer
authors.forename: H
authors.initials: H
authors.lastname: Lemoch
authors.forename: P
authors.initials: P
authors.lastname: Winkler
authors.forename: J K
authors.initials: JK
authors.lastname: Rockstroh
authors.forename: H K
authors.initials: HK
authors.lastname: Berthold
authors.forename: U
authors.initials: U
authors.lastname: Spengler
authors.forename: R
authors.initials: R
authors.lastname: Goerlich
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005419:Flavonoids; D005638:Fruit / Q000737:chemistry*; D018023:HIV Seronegativity / Q000502:physiology*; D006679:HIV Seropositivity / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D014675:Vegetables / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols