title: Analysis of the vascularity of an atelocollagen sponge substitute dermis in the human.
abstract: Atelocollagen sponge had been developed as a new beneficial dermal substitute. However, histologic studies of the vascularity of an atelocollagen sponge substitute dermis in humans are very rare. The purpose of this study was to determine the distribution of blood vessels in an artificial dermis made of atelocollagen affixed to human tissue. The artificial dermis was used in 21 cases and at 23 sites, and biopsies were performed. The samples were stained with anti-human blood type A, B, and H monoclonal antibodies. Angiogenesis in the upper layer of the artificial dermis was recognizable within 14 days after affixing the artificial dermis. We concluded that a skin graft taken 14 days after affixing the artificial dermis would be successful, even though the granulation tissue formation might not be completed and the color would most likely remain white. The lower layer of the angiogenesis spread in a horizontal direction like an expanded network of blood vessels, while the middle and upper layers of angiogenesis spread perpendicularly to form upward growth when two cases were examined in various spots. The data suggested that the sponge construction of artificial dermis not only became a scaffold for the invasion of collagen, but it also facilitated construction of near normal dermis with regard to the construction of blood vessels.
authors.affiliation: Department of Dermatology, Kumamoto University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishihara
authors.forename: T
authors.initials: T
authors.lastname: Ono
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000601:surgery; D002294:Carcinoma, Squamous Cell; D003094:Collagen; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000601:surgery; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D012867:Skin / Q000098:blood supply*; D012878:Skin Neoplasms / Q000601:surgery*; D017768:Skin, Artificial; D013997:Time Factors
chemical_list: C059821:atelocollagen; D003094:Collagen