title: [Selective serotonin reuptake inhibitor(SSRI)].
abstract: Selective serotonin reuptake inhibitors(SSRIs) are safe antidepressants and now widely used for the treatment of depression. Although there are five SSRIs(citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) available in the world, only two(fluvoxamine and paroxetine) are approved in Japan. SSRIs are also used for the treatment of obsessive-compulsive disorders, panic disorders, eating disorders and so on. Major side effects of SSRIs are gastrointestinal symptoms(especially nausea), neurological symptoms (particularly headache and tremor) and psychiatric symptoms(especially anxiety). While therapeutic effects of SSRIs seem to be related to desensitization of somatodendritic serotonin 1A autoreceptors in the raphe nuclei, other neurotransmitters and intracellular mechanisms may be also involved.
authors.affiliation: National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP).
authors.forename: N
authors.initials: N
authors.lastname: Motohashi
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy; D011903:Raphe Nuclei / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D044263:Receptors, Serotonin, 5-HT1; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017367:Selective Serotonin Reuptake Inhibitors