Locomotor-stimulating effects of indirect dopamine agonists are attenuated in Fawn hooded rats independent of postweaning social experience.
The effects of the indirect dopamine (DA) agonists cocaine and D-amphetamine on locomotor activity were examined in Fawn hooded (FH) rats and Wistar rats. The effect of isolation rearing was also examined to determine if it might have different effects in these two strains. Contrary to previous findings in other rat strains, only small increases in locomotor-stimulating responses to low doses of cocaine were observed in the present study as a result of isolation rearing. However, at higher cocaine doses, locomotor activity was substantially attenuated in FH rats relative to Wistar rats. A similar pattern of effects was observed for amphetamine in FH rats but only at the intermediate dose. The effects of strain and rearing were independent. There was no evidence for interactions between these factors.
Hall
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FS
Laboratory of Clinical Studies, D.I.C.B.R., National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA. shall@intra.nida.nih.gov
Fong
G W
GW
Ghaed
S
S
Pert
A
A
D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology; D014886:Weaning
D018491:Dopamine Agonists; D018765:Dopamine Uptake Inhibitors; D003042:Cocaine; D003913:Dextroamphetamine