title: Sustained hyperglycemia and insulin resistance induced by dietary restriction.
abstract: This investigation considered whether defects in insulin secretion and insulin action may result in the development of sustained hyperglycemia induced by refeeding standard chow pellets. Hyperglycemia, sustained for 36 h was induced, in mice that ate standard chow pellets ad libitum after 48 h fasting, but not 24 h fasting. In 48 h-fasted mice, serum insulin levels were remarkably low and the ability of insulin secretion to respond to glucose was decreased, although insulin-stimulated glucose disposal was not impaired. However, hyperinsulinemia was observed after refeeding for 12 h. The 12 h-refed mice had impaired glucose tolerance and were remarkably insulin resistant. These results suggest that hyperglycemia induced by the fasting-refeeding was caused by hyperphagia and the failure of insulin secretion, and maintained the resulting induced insulin resistance.
authors.affiliation: Department of Pharmaco-Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan. maeda@ys7.u-shizuoka-ken.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: R
authors.initials: R
authors.lastname: Sakita
authors.forename: T
authors.initials: T
authors.lastname: Kaihatsu
authors.forename: M
authors.initials: M
authors.lastname: Miwa
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005215:Fasting / Q000502:physiology*; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000097:blood*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D051379:Mice
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin