title: Localization of retrovirus in the central nervous system of a patient co-infected with HTLV-1 and HIV with HAM/TSP and HIV-associated dementia.
abstract: Persons co-infected with HTLV-1 and HIV are at increased risk for neurologic disease. These patients may develop HAM/TSP and/or HIV-associated dementia. In this study, we localized cells infected with retrovirus in the central nervous system (CNS) of a patient with both HAM/TSP and HIV-associated dementia. HTLV-1 was localized to astrocytes and HIV to macrophage/microglia. There was no co-infection of a single cell phenotype in this patient. These data suggest that mechanisms other than co-infection of the same CNS cell may play a role in the development of neurologic disease in patients dual infected with HTLV-1 and HIV.
authors.affiliation: Department of Neurology, University of Tennessee Health Sciences Center, Memphis 38163, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Levin
authors.forename: M K
authors.initials: MK
authors.lastname: Rosenblum
authors.forename: C H
authors.initials: CH
authors.lastname: Fox
authors.forename: S
authors.initials: S
authors.lastname: Jacobson
mesh_terms: D015526:AIDS Dementia Complex / Q000150:complications / Q000473:pathology / Q000821:virology*; D000328:Adult; D001253:Astrocytes / Q000473:pathology / Q000821:virology; D001921:Brain / Q000473:pathology / Q000821:virology; D002490:Central Nervous System / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D016356:Gene Products, tax / Q000235:genetics; D006678:HIV / Q000235:genetics / Q000302:isolation & purification; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008264:Macrophages / Q000473:pathology / Q000821:virology; D008297:Male; D017628:Microglia / Q000473:pathology / Q000821:virology; D015493:Paraparesis, Tropical Spastic / Q000150:complications / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D012190:Retroviridae / Q000235:genetics / Q000302:isolation & purification*; D012514:Sarcoma, Kaposi / Q000150:complications / Q000175:diagnosis; D013116:Spinal Cord / Q000473:pathology / Q000821:virology
chemical_list: D004279:DNA, Viral; D016356:Gene Products, tax; D012367:RNA, Viral