[Lipid peroxides, tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) in peritoneal fluid from infertile women with minimal and mild endometriosis].
OBJECTIVE
To assess the concentrations of tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma) and lipid peroxides (the marker of free radicals activity) in peritoneal fluid (PF) of infertile women with minimal and mild endometriosis.


METHODS
19 women were studied, including 9 infertile women with minimal or mild endometriosis and 10 patients with tubal occlusion (the reference group). Lipid peroxides (malonyldialdehyde and 4-hydroxynonenal), TNF-alpha and IFN-gamma concentrations were measured in the PF using commercially available kits.


RESULTS
Concentration of IFN-gamma was detectable in PF of 7 (77.8%) women with endometriosis and in PF from 3 (30%) patients with tubal occlusion. Neither TNF-alpha or lipid peroxides PF concentration differed significantly (p < 0.05) between the groups. In the group with endometriosis we have found a positive correlation (R = 0.77, p = 0.04) between the concentrations of TNF-alpha and IFN-gamma.


CONCLUSIONS
Our results suggest that oxidative stress in the PF doesn't appear to play a role in endometriosis-associated infertility.
Polak
G
G
Katedry i Zakładu Mikrobiologii Lekarskiej AM w Lublinie.
Kozioł-Montewka
M
M
Niedźwiadek
J
J
Tarkowski
R
R
Sidor-Wójtowicz
A
A
Kotarski
J
J
D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism; D004715:Endometriosis / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D007371:Interferon-gamma / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D000292:Pelvic Inflammatory Disease / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D008054:Lipid Peroxides; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma
Produkty peroksydacji lipidów, czynnik martwicy nowotworów alpha (TNF-alpha) oraz interferon gamma (IFN-gamma) w płynie otrzewnowym niepłodnych kobiet z łagodna postacia endometriozy.