Photoinduced DNA cleavage by cyclopentadienyl metal complexes conjugated to DNA recognition elements.
[structure: see text]. DNA recognition elements have been attached to CpW(CO)3CH3 and CpW(CO)3Ph, which produce methyl and phenyl radicals that cleave DNA upon photolysis. The inclusion of binding moieties in 3 increases the efficiency but not the selectivity of strand scission over that seen in the simple unfunctionalized complex, while 11 cleaves preferentially at T sites within AT-rich tracts.
Hurley
A L
AL
Department of Chemistry, Emory University, 1515 Pierce Dr., Atlanta, Georgia 30322, USA.
Maddox
M P
MP
Scott
T L
TL
Flood
M R
MR
Mohler
D L
DL
D003517:Cyclopentanes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000528:radiation effects*; D010777:Photochemistry; D010957:Plasmids; D014414:Tungsten / Q000737:chemistry*
D003517:Cyclopentanes; D004247:DNA; D014414:Tungsten