The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins.
Duncan
G
G
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
McCormick
C
C
Tufaro
F
F
D000117:Acetylglucosamine / Q000378:metabolism; D000328:Adult; D000818:Animals; D001704:Biopolymers; D001846:Bone Development / Q000235:genetics; D001859:Bone Neoplasms / Q000453:epidemiology / Q000235:genetics; D016466:CHO Cells; D002356:Cartilage / Q000473:pathology; D002648:Child; D006224:Cricetinae; D004252:DNA Mutational Analysis; D019143:Evolution, Molecular; D005097:Exostoses, Multiple Hereditary / Q000235:genetics*; D005799:Genes, Dominant; D005804:Genes, Lethal; D016147:Genes, Tumor Suppressor; D005816:Genetic Complementation Test; D020022:Genetic Predisposition to Disease; D020723:Glucuronic Acid / Q000378:metabolism; D006031:Glycosylation; D006497:Heparan Sulfate / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D007448:Invertebrates / Q000254:growth & development / Q000378:metabolism; D046911:Macromolecular Substances; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D017351:N-Acetylglucosaminyltransferases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D044168:Receptor, Parathyroid Hormone, Type 1; D018016:Receptors, Parathyroid Hormone / Q000378:metabolism; D012306:Risk; D013329:Structure-Activity Relationship; D014714:Vertebrates / Q000254:growth & development / Q000378:metabolism; D000099065:Exostosin 2; D000099058:Exostosin 1
D000117:Acetylglucosamine; D001704:Biopolymers; D020723:Glucuronic Acid; D006497:Heparan Sulfate; D046911:Macromolecular Substances; D017351:N-Acetylglucosaminyltransferases; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D044168:Receptor, Parathyroid Hormone, Type 1; D018016:Receptors, Parathyroid Hormone; D000099065:Exostosin 2; D000099058:Exostosin 1; C470121:PTHLH protein, human