title: The in vitro effects of remifentanil, sufentanil, fentanyl, and alfentanil on isolated human right atria.
abstract: Because some clinical studies have suggested that opioids used in anesthesia may have different deleterious hemodynamic effects, we compared the direct myocardial effects of cumulative concentrations of remifentanil, sufentanil, fentanyl, and alfentanil on inotropic and lusitropic variables of isolated human myocardium in vitro. Human right atrial trabeculae, obtained from patients scheduled for coronary bypass surgery or aortic valve replacement, were suspended vertically in an oxygenated (95% oxygen/5% CO(2)) Tyrode's modified solution ([Ca(2+)](o) = 2.0 mM, 37 degrees C, pH 7.40, stimulation frequency 1 Hz). The effects of cumulative concentrations (10(-11), 10(-10), 10(-9), 10(-8), 10(-7), and 10(-6) M) of remifentanil (n = 8), sufentanil (n = 8), fentanyl (n = 8), and alfentanil (n = 8) on inotropic and lusitropic variables of isometric twitches were measured. Remifentanil, sufentanil, and fentanyl did not modify active isometric force and peak of the positive force derivative as compared with the Control group. Alfentanil induced a dose-dependent decrease in active isometric force and peak of the positive force derivative. This effect was abolished in the presence of [Ca(2+)](o) = 4.0 mM. None of these opioids altered lusitropic variables.
authors.affiliation: Department of Anesthesiology, Center Hospitalier Universitaire, Caen, France. hanouz-jl@chu-caen.fr
authors.forename: J L
authors.initials: JL
authors.lastname: Hanouz
authors.forename: A
authors.initials: A
authors.lastname: Yvon
authors.forename: G
authors.initials: G
authors.lastname: Guesne
authors.forename: C
authors.initials: C
authors.lastname: Eustratiades
authors.forename: G
authors.initials: G
authors.lastname: Babatasi
authors.forename: R
authors.initials: R
authors.lastname: Rouet
authors.forename: P
authors.initials: P
authors.lastname: Ducouret
authors.forename: A
authors.initials: A
authors.lastname: Khayat
authors.forename: H
authors.initials: H
authors.lastname: Bricard
authors.forename: J L
authors.initials: JL
authors.lastname: Gérard
mesh_terms: D000368:Aged; D015760:Alfentanil / Q000378:metabolism / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000378:metabolism / Q000494:pharmacology*; D016280:Atrial Function, Right / Q000187:drug effects*; D005260:Female; D005283:Fentanyl / Q000378:metabolism / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010880:Piperidines / Q000378:metabolism / Q000494:pharmacology*; D000077208:Remifentanil; D017409:Sufentanil / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D015760:Alfentanil; D017409:Sufentanil; D000077208:Remifentanil; D005283:Fentanyl