Bone metastases from secondary glioblastoma multiforme: a case report.
Extraneural metastases of glioblastoma multiforme (GBM) are a relatively rare occurrence which usually manifest after de novo GBM. We report a case of a patient with an oligodendroastrocytoma who developed over a period of 12 years malignant progression to glioblastoma followed by multiple cytologically confirmed bone metastases. No 1p deletions were detected in the original tumour. GBM cells disclosed the EGFr(+) and p53(-) immunophenotype more characteristic of a primary GBM.
Cervio
A
A
Neurosurgical Department, Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.
Piedimonte
F
F
Salaberry
J
J
Alcorta
S C
SC
Salvat
J
J
Diez
B
B
Sevlever
G
G
D000328:Adult; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000556:secondary*; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed