title: De novo initiation of viral RNA-dependent RNA synthesis.
abstract: RNA viruses use several initiation strategies to ensure that their RNAs are synthesized in appropriate amounts, have correct termini, and can be translated efficiently. Many viruses with genomes of single-stranded positive-, negative-, and double-stranded RNA initiate RNA synthesis by a de novo (primer-independent) mechanism. This review summarizes biochemical features and variations of de novo initiation in viral RNA replication.
authors.affiliation: Department of Biology, Indiana University, Bloomington, Indiana 47405, USA. ckao@bio.indiana.edu
authors.forename: C C
authors.initials: CC
authors.lastname: Kao
authors.forename: P
authors.initials: P
authors.lastname: Singh
authors.forename: D J
authors.initials: DJ
authors.lastname: Ecker
mesh_terms: D018067:Flaviviridae / Q000235:genetics* / Q000502:physiology; D005544:Forecasting; D006801:Humans; D012367:RNA, Viral / Q000235:genetics*; D014779:Virus Replication
chemical_list: D012367:RNA, Viral