title: Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations.
abstract: The objective of this study was to assess the efficacy and safety of Gabapentin as the sole analgesic in patients with HIV-related painful neuropathy. Nineteen patients with HIV-related painful neuropathy were administered Gabapentin. Efficacy was evaluated with two 100-mm Visual Analogue Scales (VAS) (0: no symptom; 100: worst symptom), rating pain and interference of pain with sleep, performed at baseline and monthly intervals. Main Pain VAS score decreased from a baseline of 55.7 +/- 19.1 mm to a final 14.7 +/- 18.6 mm (ANOVA P = 0.0001) and mean Sleep Interference VAS score decreased from a baseline of 60.4 +/- 31.9 mm to a final 15.5 +/- 27.7 mm (ANOVA P = 0.0001). Gabapentin provided significant pain relief in our patients with HIV-associated painful sensory neuropathy.
authors.affiliation: Department of Neurology, Civil Hospital, Busto Arsizio, Italy.
authors.forename: I
authors.initials: I
authors.lastname: La Spina
authors.forename: D
authors.initials: D
authors.lastname: Porazzi
authors.forename: F
authors.initials: F
authors.lastname: Maggiolo
authors.forename: P
authors.initials: P
authors.lastname: Bottura
authors.forename: F
authors.initials: F
authors.lastname: Suter
mesh_terms: D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids; D005260:Female; D000077206:Gabapentin; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology*; D010146:Pain / Q000503:physiopathology; D010147:Pain Measurement; D010166:Palliative Care; D012890:Sleep; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin