[Nitric oxide as main effector in the interleukin-1 system in ovulation].
Ovulation is a complex process involving not only gonadotropins and steroid hormones, but also many local mediators common to inflammatory reactions, such as cytokines. Of particular interest is the ovarian interleukin-1 (IL-1) system, which may be an intermediary of gonadotropins in the ovulatory process. The preovulatory follicles have a complete and highly compartmentalized intraovarian IL-1 system including ligands, receptor, and receptor antagonist. IL-1 has been considered as the inductor of several ovulation-associated events such as prostaglandin and progesterone biosynthesis, plasminogen activator production, glycosaminoglycan generation, and enhancement of vascular permeability. The principal effector of the IL-1 system is nitric oxide. This paper analyzes the sites of synthesis and action of the IL-1 system in preovulatory follicle and its vascular dynamics as well as IL-1's mechanism of action in triggering follicular rupture.
Díaz Flores
M
M
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI.
Ortega-Camarillo
C
C
Rosales-Torres
A M
AM
Baiza-Gutman
L A
LA
Hicks
J J
JJ
D005260:Female; D005498:Follicular Phase / Q000502:physiology; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D009569:Nitric Oxide / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology; D010060:Ovulation / Q000502:physiology*; D011374:Progesterone / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D013739:Testosterone / Q000502:physiology
D007375:Interleukin-1; D011453:Prostaglandins; D009569:Nitric Oxide; D013739:Testosterone; D011374:Progesterone
El óxido nítrico como principal efector del sistema de la interleucina-1 en la ovulación.