Plasma antioxidant capacity of HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit-vegetable-concentrate containing antioxidant polyphenols.
OBJECTIVE
To investigate whether antioxidant polyphenols from fruit juices or a fruit-vegetable-concentrate increase the plasma antioxidant capacity in HIV-infected and healthy subjects.


METHODS
Twenty-three HIV-seropositive and 18 seronegative adults were randomized to ingest either 1 l of fruit juice or 30 ml fruit-vegetable-concentrate per day over 16 weeks in addition to their normal Western diet.


METHODS
Plasma antioxidant capacity was determined as Trolox equivalent antioxidant capacity (TEAC) at baseline, after 1 and 16 weeks of intervention, and after a 6 week washout.


RESULTS
There was no difference in plasma antioxidant capacity between HIV-infected and healthy subjects at baseline (P=0.1). After 16 weeks of intervention TEAC increased in HIV-positive subjects with both types of polyphenol supplementation (juice, 1.38+/-0.07 to 1.42+/-0.04 mM, P=0.034; concentrate, 1.40+/-0.09 to 1.46+/-0.08 mM, P=0.025). TEAC was not altered by either type of supplementation in HIV-seronegative subjects.


CONCLUSIONS
Plasma antioxidant capacity can be increased by long-term ingestion of polyphenols from fruit juices or fruit-vegetable-concentrate in HIV-seropositive but not in HIV-seronegative subjects.


BACKGROUND
This study was supported by a grant and Cellagon aurum from HG Berner GmbH, Altenholz, and fruit juices from Eckes Granini GmbH & Co. KG, Nieder-Olm.
Arendt
B M
BM
School of Medicine, Department of Hemostasis and Transfusion Medicine, University of Düsseldorf, Düsseldorf, Germany.
Boetzer
A M
AM
Lemoch
H
H
Winkler
P
P
Rockstroh
J K
JK
Berthold
H K
HK
Spengler
U
U
Goerlich
R
R
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005419:Flavonoids; D005638:Fruit / Q000737:chemistry*; D018023:HIV Seronegativity / Q000502:physiology*; D006679:HIV Seropositivity / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D014675:Vegetables / Q000737:chemistry*
D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols