[Fas and ICE expression in the hepatocytes of tupaia with HDV/HBV infection].
OBJECTIVE
To investigate the relationship between Fas and ICE expression and HDV infection.


METHODS
HDAg, Fas, and ICE were determined in 45 liver tissue specimens of tupaia with HDV/HBV infection by immunohistochemistry.


RESULTS
Fas was detected in 39 out of 45 liver tissue specimens (86.7%), and ICE in 43 (95.6%). Fas and ICE were located in the cytoplasm or/and the membrane of hepatocytes, especially in the cytoplasm. There was significant correlation between the expression of HDAg and the expression of Fas and ICE (chi(2)=29.2 and 36.2, respectively, P<0.01).


CONCLUSIONS
The expression of Fas and ICE may be induced by HDAg in hepatocytes.
Jiang
Y
Y
Institute of Infectious Diseases. Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Li
Q
Q
Wang
Y
Y
Gu
C
C
D000818:Animals; D020170:Caspase 1 / Q000032:analysis / Q000096:biosynthesis*; D018963:Hepatitis Antigens / Q000032:analysis; D006509:Hepatitis B / Q000378:metabolism*; D003699:Hepatitis D / Q000378:metabolism*; D035923:Hepatitis delta Antigens; D022781:Hepatocytes / Q000378:metabolism* / Q000821:virology; D014417:Tupaia; D019014:fas Receptor / Q000032:analysis / Q000096:biosynthesis*
D018963:Hepatitis Antigens; D035923:Hepatitis delta Antigens; D019014:fas Receptor; D020170:Caspase 1