title: [The role of quantitative determination of the volume fraction of interstitial collagen and fibronectin in the pathogenesis of myocardial remodeling in dilated cardiomyopathy].
abstract: The role of myocardial fibrosis in the pathogenesis of left-ventriclar remodeling was studied in patients with idiopathic and ischemic dilatation cardiomyopathy.  The percentage of volumic collagen fraction in the left-ventricular myocardium was significantly increased, this increase correlating with the degree of dilatation of  left-ventricular cavity.  A sufficient increase of plasma fibromectin level was observed in patients with idiopathic dilatation cardiomyopathy at all stages of circulatory insufficiency.
authors.forename: S
authors.initials: S
authors.lastname: Sisakian
authors.forename: L V
authors.initials: LV
authors.lastname: Gukasian
authors.forename: L G
authors.initials: LG
authors.lastname: Mkrtshian
authors.forename: G G
authors.initials: GG
authors.lastname: Kamalov
authors.forename: S A
authors.initials: SA
authors.lastname: Avakian
mesh_terms: D000790:Angiocardiography / Q000379:methods; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000378:metabolism* / Q000503:physiopathology; D004452:Echocardiography; D005353:Fibronectins / Q000378:metabolism*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism*; D009200:Myocardial Contraction / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D005353:Fibronectins; D020781:Matrix Metalloproteinase 1
vernacular_title: Rol' kolichestvennogo opredeliniia ob''emnoĭ fraktsii interstitsial'nogo kollagena i fibronektina v patogeneze remodelirovaniia miokarda pri dilatatsionnoĭ kardiomiopatii.