title: Quantitative comparisons of 16S rRNA gene sequence libraries from environmental samples.
abstract: To determine the significance of differences between clonal libraries of environmental rRNA gene sequences, differences between homologous coverage curves, CX(D), and heterologous coverage curves, CXY(D), were calculated by a Cramér-von Mises-type statistic and compared by a Monte Carlo test procedure. This method successfully distinguished rRNA gene sequence libraries from soil and bioreactors and correctly failed to find differences between libraries of the same composition.
authors.affiliation: Department of Microbiology, University of Georgia, Athens, Georgia 30602-2605, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Singleton
authors.forename: M A
authors.initials: MA
authors.lastname: Furlong
authors.forename: S L
authors.initials: SL
authors.lastname: Rathbun
authors.forename: W B
authors.initials: WB
authors.lastname: Whitman
mesh_terms: D019149:Bioreactors; D015723:Gene Library; D020459:Genes, rRNA; D009010:Monte Carlo Method; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012988:Soil Microbiology
chemical_list: D012336:RNA, Ribosomal, 16S