title: Successfully resected hepatoblastoma in a young adult with chronic hepatitis B: report of a case.
abstract: Hepatoblastoma usually occurs in children, but a few cases have also been reported in adults. We report the unusual case of hepatoblastoma in an 18-year-old adult with chronic hepatitis B. He visited a local hospital with right upper abdominal pain. Abdominal ultrasound showed a large mass in the right lobe of his liver. He was referred to our hospital and admitted for further examination. At admission, liver function tests gave slightly elevated results (aspartate aminotransferase (AST) 103 IU/l, alanine aminotransferase (ALT) 63 IU/l). A test for hepatitis virus revealed that he was a hepatitis B surface antigen (HBsAg) carrier and had experienced seroconversion. His alpha-fetoprotein (AFP) was elevated to 1 548 000 IU/ml. Abdominal ultrasound showed a 109 x 96 x 80-mm mass with mosaic pattern in the right lobe of the liver and right portal vein thrombus. Abdominal computed tomography (CT) demonstrated a large low-density mass occupying the right lobe, with some high-density parts that showed calcification. From these results, we diagnosed hepatoblastoma in a young adult. A right lobectomy was performed. Pathological examination showed a highly differentiated hepatoblastoma. Adjuvant chemotherapy was performed with cisplatin and pirarubicin. The patient has been well and free of recurrence for 12 months, and his AFP level remains almost normal.
authors.affiliation: First Department of Surgery, Okayama University Medical School, Okayama, Japan. alfa167@md.okayama-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Inagaki
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: N
authors.initials: N
authors.lastname: Urushihara
authors.forename: Y
authors.initials: Y
authors.lastname: Shima
authors.forename: H
authors.initials: H
authors.lastname: Sadamori
authors.forename: N
authors.initials: N
authors.lastname: Takakura
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Oda
mesh_terms: D000293:Adolescent; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000175:diagnosis; D006521:Hepatitis, Chronic / Q000150:complications* / Q000175:diagnosis; D018197:Hepatoblastoma / Q000150:complications / Q000175:diagnosis / Q000601:surgery* / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery* / Q000628:therapy; D008297:Male