[Ribosome and the secret of longevity].
Proteins in cells are constantly undergoing damage. Nevertheless, the concentration of damaged proteins in young organisms is maintained at the low level due to the continual protein turnover: degradation of damaged proteins and synthesis of new ones. During aging, the concentration of damaged proteins increases because of decelerating protein turnover, the cause of which is unknown, however, it may be related to the decrease in ribosome concentration.
Riazanov
A G
AG
Department of Pharmacology, University of Medicine & Dentistry of New Jersey, Robert Wood Johnson Medical School, NJ 08854, USA. ryazanag@UMDNJ.EDU
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002648:Child; D006801:Humans; D008136:Longevity / Q000502:physiology*; D008875:Middle Aged; D014176:Protein Biosynthesis / Q000502:physiology; D011506:Proteins / Q000502:physiology; D012270:Ribosomes / Q000502:physiology*
D011506:Proteins
Ribosoma i sekret dolgoletiia.