[The epidemiology and pathogenesis of postpartum depression].
Mood disorders--maternity blues, depression and bipolar disorders with psychotic features--are common and increased in rate during the postpartum period as compared to the non-postpartum period. Several authors showed a frequent recurrence of postpartum depression in women with a history of postpartum depression. Bloch, et al: (2000) showed that 5 of 8 women(62.5%) with a history of postpartum depression and none of the 8 control women developed significant mood symptoms during the withdrawal from high serum levels of progesterone and estradiol. These findings indicate that a history of postpartum depression produces hypersensitivity or reverse tolerance to subsequent exposure to an acute decrease of gonadal steroids at least for a subgroup of women with a past postpartum depression.
Okazaki
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Y
Department of Psychiatry, Mie University School of Medicine.
D000328:Adult; D019052:Depression, Postpartum / Q000453:epidemiology / Q000209:etiology; D004958:Estradiol / Q000097:blood / Q000502:physiology / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D020249:Hormone Replacement Therapy; D006801:Humans; D011247:Pregnancy; D011374:Progesterone / Q000097:blood / Q000502:physiology / Q000627:therapeutic use
D011374:Progesterone; D004958:Estradiol