Monstrous attempts at adnexogenesis: regulating hair follicle progenitors through Sonic hedgehog signaling.
Epithelial organs such as the vertebrate hair control periodic self-renewal by regulating the growth of progenitor cells. Recent studies implicate Sonic hedgehog target gene induction in the growth of multipotent hair follicle epithelium and the development of a variety of hair follicle tumors such as basal cell carcinomas. These studies suggest Sonic hedgehog signaling may regulate progenitor cells in other organs.
Callahan
C A
CA
Program in Epithelial Biology, Stanford University, CCSR Building, Room 2145, 269 Campus Drive, Stanford, CA 94305-5168, USA.
Oro
A E
AE
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002352:Carrier Proteins; D002454:Cell Differentiation; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D018507:Gene Expression Regulation, Developmental; D018859:Hair Follicle / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism* / Q000473:pathology; D053823:Hedgehog Proteins; D006801:Humans; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation; D000099176:Noggin Protein
D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D053823:Hedgehog Proteins; D011506:Proteins; D015534:Trans-Activators; D000099176:Noggin Protein; C509239:SHH protein, human