Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy.
We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-alpha (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.
Sommer
C
C
Neurologische Klinik der Universität Würzburg, Josef-Schneider-Strasse 11, 97080 Würzburg, Germany. sommer@mail.uni-wuerzburg.de
Lindenlaub
T
T
Teuteberg
P
P
Schäfers
M
M
Hartung
T
T
Toyka
K V
KV
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001369:Axons / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D006930:Hyperalgesia / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D020422:Mononeuropathies / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D009410:Nerve Degeneration / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D009437:Neuralgia / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D017288:Pain Threshold / Q000187:drug effects* / Q000502:physiology; D012584:Sciatic Nerve / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism
D000906:Antibodies; D014409:Tumor Necrosis Factor-alpha