title: Catalytic cyclopropanation of alkenes using diazo compounds generated in situ. A novel route to 2-arylcyclopropylamines.
abstract: [reaction: see text]. A user-friendly, one-pot process for catalytic cyclopropanation of alkenes from tosylhydrazones is described. The cyclopropanation of N-vinylphthalimide provides a new route to 2-arylcyclopropylamines, and this is exemplified in the efficient synthesis of the HIV-1 reverse transcriptase inhibitor 6.
authors.affiliation: School of Chemistry, Bristol University, Cantock's Close, Bristol BS8 1TS, UK. v.aggrarwal@bristol.ac.uk
authors.forename: V K
authors.initials: VK
authors.lastname: Aggarwal
authors.forename: J
authors.initials: J
authors.lastname: de Vicente
authors.forename: R V
authors.initials: RV
authors.lastname: Bonnert