Numerical modelling of the perturbation of HIV-1 during combination anti-retroviral therapy.
A competitive, chaos-free, implicit, finite-difference method is developed and used for a novel deterministic model for the perturbation of HIV by combination antiretroviral therapy. The compartmental model monitors the interaction between HIV and CD4(+) T cells, its principal target and site of replication in vivo, in the presence of reverse transcription inhibitors and protease inhibitors. The model exhibits two steady states, an uninfected (trivial) steady state (with no virus present) and an endemically infected state (with virus and infected T cells present). Stability and bifurcation analyses together with numerical simulations of the resulting dynamical system are reported.
Gumel
A B
AB
Department of Mathematics, University of Manitoba, Winnipeg, Canada R3T 2N2. gumelab@cc.umanitoba.ca
Loewen
T D
TD
Shivakumar
P N
PN
Sahai
B M
BM
Yu
P
P
Garba
M L
ML
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D003198:Computer Simulation; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical
D019380:Anti-HIV Agents