Changes in brain activity related to eating chocolate: from pleasure to aversion.
We performed successive H(2)(15)O-PET scans on volunteers as they ate chocolate to beyond satiety. Thus, the sensory stimulus and act (eating) were held constant while the reward value of the chocolate and motivation of the subject to eat were manipulated by feeding. Non-specific effects of satiety (such as feelings of fullness and autonomic changes) were also present and probably contributed to the modulation of brain activity. After eating each piece of chocolate, subjects gave ratings of how pleasant/unpleasant the chocolate was and of how much they did or did not want another piece of chocolate. Regional cerebral blood flow was then regressed against subjects' ratings. Different groups of structures were recruited selectively depending on whether subjects were eating chocolate when they were highly motivated to eat and rated the chocolate as very pleasant [subcallosal region, caudomedial orbitofrontal cortex (OFC), insula/operculum, striatum and midbrain] or whether they ate chocolate despite being satiated (parahippocampal gyrus, caudolateral OFC and prefrontal regions). As predicted, modulation was observed in cortical chemosensory areas, including the insula and caudomedial and caudolateral OFC, suggesting that the reward value of food is represented here. Of particular interest, the medial and lateral caudal OFC showed opposite patterns of activity. This pattern of activity indicates that there may be a functional segregation of the neural representation of reward and punishment within this region. The only brain region that was active during both positive and negative compared with neutral conditions was the posterior cingulate cortex. Therefore, these results support the hypothesis that there are two separate motivational systems: one orchestrating approach and another avoidance behaviours.
Small
D M
DM
Neuropsychology/Cognitive Neuroscience Unit, and Northwestern Cognitive Brain Mapping Group, Northwestern University School of Medicine, Chicago, IL 60611, USA. d-small@northwestern.edu
Zatorre
R J
RJ
Dagher
A
A
Evans
A C
AC
Jones-Gotman
M
M
D001362:Avoidance Learning / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002099:Cacao; D002560:Cerebrovascular Circulation / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D012201:Reward; D012528:Satiety Response / Q000502:physiology*; D013649:Taste / Q000502:physiology*; D014055:Tomography, Emission-Computed