title: Cytotoxicity and lipid peroxidation-inhibiting activity of flavonoids.
abstract: Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship was established. Subsequently, an antioxidant selectivity index, i. e., the maximal non-toxic dose divided by the IC(50) value for lipid peroxidation, was introduced. Kaempferol showed the highest antioxidant selectivity index of all flavonoids tested.
authors.affiliation: Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Cos
authors.forename: M
authors.initials: M
authors.lastname: Calomme
authors.forename: J B
authors.initials: JB
authors.lastname: Sindambiwe
authors.forename: T
authors.initials: T
authors.lastname: De Bruyne
authors.forename: K
authors.initials: K
authors.lastname: Cimanga
authors.forename: L
authors.initials: L
authors.lastname: Pieters
authors.forename: A J
authors.initials: AJ
authors.lastname: Vlietinck
authors.forename: D
authors.initials: D
authors.lastname: Vanden Berghe
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects; D005419:Flavonoids / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D006801:Humans; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D005419:Flavonoids