Skin flux during reactive hyperemia and local hyperthermia in patients with preeclampsia.
OBJECTIVE
To test the contribution of the endothelium to the maximum vasodilatation in patients with preeclampsia and healthy pregnant controls.


METHODS
Laser-Doppler flowmetry, which is a noninvasive method for the continuous measurement of skin blood flow, was used to test the response of skin microcirculation to the above-mentioned stimuli in 14 patients with preeclampsia and 20 normotensive pregnant controls.


RESULTS
In normotensive pregnant controls, the reactive hyperemic response after a 3-minute ischemia in the forearm reaches values of 77 +/- 16% of the maximum vasodilatation, which was induced by local hyperthermia of 42C. In patients with preeclampsia, this response was significantly (P <.05) reduced (43 +/- 9%).


CONCLUSIONS
Vascular reactivity is altered in skin vessels of patients with preeclampsia in vivo. This alteration seems to be attributable mainly to the endothelium.
Beinder
E
E
University Hospital of Erlangen/Nuremberg, Department of Obstetrics, Erlangen, Germany. ernst.beinder@gyn.med.uni-erlangen.de
Schlembach
D
D
D000328:Adult; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005542:Forearm; D006801:Humans; D006940:Hyperemia / Q000209:etiology / Q000503:physiopathology*; D006979:Hyperthermia, Induced; D007511:Ischemia / Q000150:complications; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D012867:Skin / Q000098:blood supply*; D014664:Vasodilation