title: Mechanics of the carotid artery wall and baroreflex sensitivity after acute ethanol administration in young healthy volunteers.
abstract: The effects of ethanol administered orally (300 mg/kg in 250 ml of water) or intravenously (7.5 mg.min(-1).kg(-1) in 250 ml of saline over 40 min) on common carotid haemodynamics, wall mechanics and baroreflex sensitivity were compared with the effects of the intravenous infusion of 250 ml of saline. Ethanol or saline was administered to 10 healthy volunteers after 30 min of supine rest, and measurements were obtained 40 min (median; range 34-46 min) after administration. After ethanol administration, the plasma alcohol level rose from 0 to 0.3+/-0.07 g/l. Mean arterial blood pressure had risen slightly at 20 min, but was normalized by 40 min, the time at which the haemodynamic study was performed. Heart rate decreased after infusion of either saline or alcohol, but was unchanged after oral ethanol administration. Both oral and intravenous ethanol administration were associated with significant decreases in baroreflex sensitivity, carotid shear stress and blood velocity, compared with resting values, while the mean carotid artery diameter was increased, and blood viscosity and mean blood flow were unchanged. No changes were observed in these parameters after saline administration. Ethanol, administered either intravenously or orally, increased the stiffness of the carotid artery and decreased the pulsatility (systo-diastolic changes) of its diameter. A direct, statistically significant correlation was found between the decrease in shear stress and the decrease in baroreflex heart rate control sensitivity after both modes of alcohol administration, while no such correlation was found between the increase in the Peterson elastic modulus and the decrease in carotid diameter pulsatility on the one hand or the decrease in baroreflex sensitivity on the other. In conclusion, reduced shear stress associated with vasodilatation of the carotid artery wall may contribute to the decrease in baroreflex sensitivity observed after acute ethanol administration.
authors.affiliation: Department of Clinical Medicine, University of Trieste, Ospedale di Cattinara, 34149 Trieste, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fazio
authors.forename: M
authors.initials: M
authors.lastname: Bardelli
authors.forename: L
authors.initials: L
authors.lastname: Macaluso
authors.forename: F
authors.initials: F
authors.lastname: Fiammengo
authors.forename: P L
authors.initials: PL
authors.lastname: Mattei
authors.forename: M
authors.initials: M
authors.lastname: Bossi
authors.forename: B
authors.initials: B
authors.lastname: Fabris
authors.forename: F
authors.initials: F
authors.lastname: Fischetti
authors.forename: L
authors.initials: L
authors.lastname: Pascazio
authors.forename: R
authors.initials: R
authors.lastname: Candido
authors.forename: R
authors.initials: R
authors.lastname: Carretta
mesh_terms: D000284:Administration, Oral; D000328:Adult; D017704:Baroreflex / Q000187:drug effects*; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D002339:Carotid Arteries / Q000187:drug effects* / Q000503:physiopathology; D004548:Elasticity; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D011673:Pulsatile Flow / Q000187:drug effects; D013314:Stress, Mechanical
chemical_list: D010656:Phenylephrine; D000431:Ethanol