Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic.
We initiated a prospective surveillance study to investigate possible Pseudomonas aeruginosa cross-infection in our cystic fibrosis centre. We characterised isolates by pyocin typing and pulsed-field gel electrophoresis. 22 (14%) of 154 patients with chronic P aeruginosa had isolates with similar and new pyocin and pulsed-field gel electrophoresis types. The shared isolates showed unusual phenotypic features: they were non-pigmented, non-motile, and resistant to a number of antipseudomonal antibiotics. Cross-infection by a multiresistant P aeruginosa strain has therefore occurred in patients attending our cystic fibrosis centre. We recommend microbiological surveillance in other cystic fibrosis centres.
Jones
A M
AM
Govan
J R
JR
Doherty
C J
CJ
Dodd
M E
ME
Isalska
B J
BJ
Stanbridge
T N
TN
Webb
A K
AK
D000328:Adult; D003428:Cross Infection / Q000382:microbiology* / Q000635:transmission*; D003550:Cystic Fibrosis / Q000382:microbiology*; D016172:DNA Fingerprinting; D004352:Drug Resistance, Microbial; D016521:Electrophoresis, Gel, Pulsed-Field; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype; D011159:Population Surveillance; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000635:transmission*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification* / Q000472:pathogenicity