Foxn4--a new member of the forkhead gene family is expressed in the retina.
We report the cloning and expression of a novel murine forkhead/winged helix family member--Foxn4--that is expressed during neural development in the retina, the ventral hindbrain and spinal cord and dorsal midbrain. Retinal Foxn4 expression is associated with the zone of proliferating progenitor cells. In the mouse mutant ocular retardation (or(J)), Foxn4 expression in the retina is significantly reduced and terminates prematurely.
Gouge
A
A
The Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK.
Holt
J
J
Hardy
A P
AP
Sowden
J C
JC
Smith
H K
HK
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D003001:Cloning, Molecular; D005136:Eye Proteins / Q000737:chemistry / Q000235:genetics*; D051858:Forkhead Transcription Factors; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D012160:Retina / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism; D013116:Spinal Cord / Q000196:embryology / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*
D005136:Eye Proteins; D051858:Forkhead Transcription Factors; C438622:Foxn4 protein, mouse; D014157:Transcription Factors