title: [Vascular depression].
abstract: It has been reported that 20-65% of cerebral infarction patients suffers from depression. On the other hand, elderly-onset depression has more cerebro-vascular changes such as deep white matter lesion and periventricular hyperintensity on MRI than young-onset depression. These findings together leads new disease category 'vascular depression' (VD), meaning depression primarily caused by cerebral infarction. VD patients show less family history and symptomatic changes within a day than those with non-vascular depression. Though anti-depressants are effective on VD, they have higher incidence of side effect on VD than on non-vascular depression. Benzodiazepines and cerebral circulation and metabolism enhancers are also used in VD therapy. The prognosis of VD is worse than that of non-VD or cerebral infarction without depression.
authors.affiliation: Department of Clinical Neuroscience, Psychiatry, Osaka University, Graduate School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Kurumatani
authors.forename: M
authors.initials: M
authors.lastname: Takeda
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D015140:Dementia, Vascular / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D016666:Fluvoxamine / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D011379:Prognosis; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors