title: Flow-injection extraction-spectrophotometric method for the determination of ranitidine in pharmaceutical preparations.
abstract: The spectrophotometric determination of trace amounts of ranitidine was carried out by liquid-liquid extraction using bromothymol blue with a flow system. The determination of ranitidine in the range of 1 x 10(-5) - 1 x 10(-4) mol l(-1) was possible with a sampling frequency of 40 samples h(-1). The method was satisfactorily applied to the determination of ranitidine in pharmaceutical preparations and the recovery was quantitative and no interferences from excipients were observed.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071, Murcia, Spain. tpr@um.es
authors.forename: T
authors.initials: T
authors.lastname: Pérez-Ruiz
authors.forename: C
authors.initials: C
authors.lastname: Martínez-Lozano
authors.forename: V
authors.initials: V
authors.lastname: Tomás
authors.forename: A
authors.initials: A
authors.lastname: Sanz
authors.forename: E
authors.initials: E
authors.lastname: Sahuquillo
mesh_terms: D000897:Anti-Ulcer Agents / Q000032:analysis*; D001979:Bromthymol Blue; D017022:Flow Injection Analysis / Q000295:instrumentation* / Q000379:methods; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011899:Ranitidine / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods; D013678:Technology, Pharmaceutical
chemical_list: D000897:Anti-Ulcer Agents; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D011899:Ranitidine; D001979:Bromthymol Blue