[Adaptive effects of hypoxic preconditioning in brain neurons].
A preventive short-term hypoxia (preconditioning) increases neuronal resistance against subsequent strong hypoxic effects. Literature review and authors' own data on molecular-cellular mechanisms of the hypoxic preconditioning, are presented. Participation of intracellular signal transduction, genome, stress-proteins, and neuromodulating peptides in this process, is discussed. The role of glutamatergic as well as calcium and phosphoinositide regulatory systems and neuromodulating factors as the components of a "volume" signal transmission are analyzed in hypoxic precondition-associated induction of functional tolerance mechanisms against acute harmful effects in neurones of olfactory slices.
Samoĭlov
M O
MO
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6.
Lazarevich
E V
EV
Semenov
D G
DG
Mokrushin
A A
AA
Tiul'kova
E I
EI
Romanovskiĭ
D Iu
DIu
Miliakova
E A
EA
Dudkin
K N
KN
D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D015687:Cell Hypoxia; D016678:Genome; D006360:Heat-Shock Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
D006360:Heat-Shock Proteins
Adaptivnye éffekty gipoksicheskogo prekonditsionirovaniia neĭronov mozga.