A first step toward understanding membrane fusion induced by herpes simplex virus.
In this issue of Molecular Cell, Carfí et al. present the X-ray structure of the N-terminal domains of HveA, a TNF receptor family member, in complex with herpes simplex virus gD, providing a first step to understanding the herpesvirus mode of membrane fusion.
Spear
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Department of Microbiology-Immunology, Northwestern University Medical School, 60611, Chicago, IL, USA.
D000818:Animals; D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D008561:Membrane Fusion; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry* / Q000378:metabolism; D053240:Receptors, Tumor Necrosis Factor, Member 14; D011991:Receptors, Virus / Q000737:chemistry* / Q000378:metabolism; D018139:Simplexvirus; D014759:Viral Envelope Proteins / Q000737:chemistry* / Q000378:metabolism
D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor; D053240:Receptors, Tumor Necrosis Factor, Member 14; D011991:Receptors, Virus; C506028:TNFRSF14 protein, human; D014759:Viral Envelope Proteins; C039447:glycoprotein D, Human herpesvirus 1