title: Facile three-component coupling procedure for the synthesis of substituted tetrahydroisoindole-1,3-diones from alpha,beta-unsaturated aldehydes.
abstract: [reaction: see text]. A new one-pot procedure for the efficient synthesis of a small library of amino-functionalized tetrahydroisoindole-1,3-dione derivatives was developed. This three-component coupling reaction comprises subsequent condensation and Diels-Alder reactions of ubiquitous available starting materials (alpha,beta-unsaturated aldehydes, amide, and maleimide). The synthesized compounds share a substituted tetrahydroisoindole motif in an endo fashion.
authors.affiliation: Institut für Organische Katalyseforschung an der Universität Rostock e.V., Buchbinderstr. 5-6, 18055 Rostock, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Jacobi von Wangelin
authors.forename: H
authors.initials: H
authors.lastname: Neumann
authors.forename: D
authors.initials: D
authors.lastname: Gördes
authors.forename: A
authors.initials: A
authors.lastname: Spannenberg
authors.forename: M
authors.initials: M
authors.lastname: Beller