Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota.
The organic soluble extract from the leaves of Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the observed anti-viral activity. Extensive spectroscopic experiments provide the complete 1H NMR and 13C NMR spectral assignments to support the proposed structure. Known compounds glepidotin B and glepidotin A were also isolated from the extract and shown to be inactive in the anti-viral assay.
Manfredi
K P
KP
Department of Chemistry, University of Northern Iowa, Cedar Falls, IA 50614, USA. manfredi@uni.edu
Vallurupalli
V
V
Demidova
M
M
Kindscher
K
K
Pannell
L K
LK
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001632:Bibenzyls / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002247:Carbon Isotopes; D002460:Cell Line; D006035:Glycyrrhiza / Q000737:chemistry*; D006678:HIV / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013267:Stilbenes
D019380:Anti-HIV Agents; D001632:Bibenzyls; D002247:Carbon Isotopes; D013267:Stilbenes; C441193:glepidotin A; C441194:glepidotin B