title: Proton magnetic resonance spectroscopy of brain metabolites in galactosemia.
abstract: Brain edema may occur in infants with galactosemia and has been associated with accumulation of galactitol. Proton magnetic resonance spectra were obtained from 12 patients (four newly diagnosed neonates and eight patients on galactose-restricted diets, age range 1.7-47 years) and control subjects to measure brain galactitol levels in vivo and correlate them with urinary galactitol excretion. The results demonstrate that a markedly elevated brain galactitol level may be present only in newborn infants with galactosemia who exhibit massive urinary galactitol excretion.
authors.affiliation: Department of Radiology, The Children's Hospital of Philadelphia, PA 19104, USA. wang@email.chop.edu
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Wang
authors.forename: G T
authors.initials: GT
authors.lastname: Berry
authors.forename: S F
authors.initials: SF
authors.lastname: Dreha
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.forename: S
authors.initials: S
authors.lastname: Segal
authors.forename: R A
authors.initials: RA
authors.lastname: Zimmerman
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism*; D002648:Child; D005260:Female; D005693:Galactosemias / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011522:Protons
chemical_list: D011522:Protons