title: Disodium clodronate in the treatment of diffuse sclerosing osteomyelitis (DSO) of the mandible.
abstract: Diffuse sclerosing osteomyelitis (DSO) of the mandible is a chronic condition, the cause of which is not known. Jaw pain, occurring irregularly, is a typical symptom. The aim of the study was to assess the effectiveness of disodium clodronate for relieving pain in patients with DSO. Disodium clodronate is a bisphosphonate used to treat diseases of bone and calcium metabolism. Ten DSO patients experiencing pain received disodium clodronate or placebo intravenously on a randomized double-blind basis. Both minimum (300 mg) and maximum (900 mg) doses were well tolerated. Disodium clodronate administration did not result in better immediate pain relief than placebo administration. However, 6 months after treatment there was a statistically significant difference in pain intensity between the groups, with the disodium clodronate group experiencing significantly less pain.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital, Finland. marjut.montonen@hus.fi
authors.forename: M
authors.initials: M
authors.lastname: Montonen
authors.forename: E
authors.initials: E
authors.lastname: Kalso
authors.forename: L
authors.initials: L
authors.lastname: Pylkkären
authors.forename: B M
authors.initials: BM
authors.lastname: Lindströrm
authors.forename: C
authors.initials: C
authors.lastname: Lindqvist
mesh_terms: D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000704:Analysis of Variance; D002908:Chronic Disease; D004002:Clodronic Acid / Q000008:administration & dosage*; D004311:Double-Blind Method; D005157:Facial Pain / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008336:Mandibular Diseases / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications / Q000188:drug therapy*; D010147:Pain Measurement; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D004002:Clodronic Acid