Parallel solid-phase synthesis of nucleoside phosphoramidate libraries.
Combinatorial chemistry is playing an increasingly prominent role in the process of drug discovery. A nucleic acid-based (NAB) scaffold can be engineered to create functional group and topological diversity in a library. Described herein is the parallel solid-phase synthesis of combinatorial libraries of nucleoside phosphoramidates, and the first evaluation of antiviral activity against hepatitis B virus (HBV).
Jin
Y
Y
Origenix Technologies Inc., 230 Bernard-Belleau, Suite 210, Laval, H7V 4A9, Québec, Canada.
Chen
X
X
Côté
M
M
Roland
A
A
Korba
B
B
Mounir
S
S
Iyer
R P
RP
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006515:Hepatitis B virus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000577:Amides; D000998:Antiviral Agents; D009711:Nucleotides; D010756:Phosphoric Acids; C011067:phosphoramidic acid