[Heterogeneity of causes of proteinuria in patients with non-insulin dependent diabetes mellitus].
OBJECTIVE
To make a retrospective clinicomorphological (autopsy) study of proteinuria causes.


METHODS
The records have been analysed for 231 patients with non-insulin-dependent diabetes mellitus (NIDDM) over 60 years of age who died in a general hospital between 1990 and 1999. The choice of patients with diabetic nephropathy (DN) for a further morphological investigation was based on the presence of proteinuria (> 0.5 g/day), normal renal function. 72 patients met the above criteria. Of them 26 were women.


RESULTS
Proteinuria occurred more frequently in men (63.4%). A morphological examination of the kidneys revealed diabetic glomerulosclerosis (diffuse and focal) in 48(67%) patients. In 24(33%) patients proteinuria resulted from non-diabetic affection of the kidneys: amyloidosis, atherosclerotic and/or hypertensive nephroangiosclerosis, membraneous and myelomic nephropathy, mesangioproliferative glomerulonephritis. Glomerular changes were not registered in 4 patients. 35(72%) DN patients had diabetic retinopathy which was not found in patients with non-diabetic renal affection.


CONCLUSIONS
Diabetic retinopathy in patients with NIDDM and proteinuria allows to conclude that the latter is consequent to DN. The absence of diabetic retinopathy in such patients promotes a search for other causes of proteinuria.
Gordeev
A V
AV
Peskov
D Iu
DIu
D000367:Age Factors; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis; D003928:Diabetic Nephropathies / Q000150:complications* / Q000175:diagnosis; D003930:Diabetic Retinopathy / Q000150:complications / Q000175:diagnosis; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology*; D012737:Sex Factors; D013997:Time Factors
Geterogennost' prichin proteinurii u bol'nykh insulinnezavisimym sakharnym diabetom.