Polymorphism in the promoter region of the gene encoding human allograft inflammatory factor-1.
We have identified a new single nucleotide polymorphism within the promoter region of the human allograft inflammatory factor (AIF-1) gene. The polymorphism, defined by Genbank accession number AF097515, was characterized as a C/T single base pair substitution at position -932. The T allele is associated with both HLA-DR2 and HLA-B7. Also, this allele creates the consensus binding site for the E-box that has high affinity for the basic helix-loop-helix (bHLH) family of transcription factors.
Turner
D M
DM
School of Biological Sciences, University of Manchester, Manchester, UK.
Pravica
V
V
Sinnott
P J
PJ
Hutchinson
I V
IV
D000483:Alleles; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000235:genetics*; D004268:DNA-Binding Proteins; D005787:Gene Frequency / Q000235:genetics; D015793:HLA-B7 Antigen / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D008840:Microfilament Proteins; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*
C112986:AIF1 protein, human; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D015793:HLA-B7 Antigen; D006684:HLA-DR Antigens; D008840:Microfilament Proteins