Intercalation compounds of layered materials for drug delivery use. II. Diclofenac sodium.
Intercalation compounds of ternary layered inorganic materials, synthetic mica (Na-TSM), with diclofenac sodium (DFS) and its drug release characteristics were investigated. Hygroscopic DFS was selected as a model drug to verify the anti-humidity and anti-oxidation of the intercalation compounds. Na-TSM powder was first mixed with the reduced-type phosphatidylcholine (H-PC) solution of chloroform or ethanol. DFS was then mixed with these solutions and heated at 37 degrees C to prepare the ternary Na-TSM/H-PC/DFS compound. A remarkable phenomenon was observed in the drug release study. The net amount of DFS from the DFS powder decreased apparently after 20 min arising from the decomposition of DFS in acidic medium. On the other hand, the net amount of the released DFS from the intercalation compound was invariant. Thermal analyses study indicated that DFS powder was hygroscopic and a significant endothermic peak was observed accompanied by a large weight loss due to the dehydration of adsorbed water from 40 to 90 degrees C. On the other hand, no significant dehydration reaction was observed in the intercalation compounds even in the sample stored under humid conditions. The present results indicated that the ternary intercalation compound was resistant to acid in addition to anti-humidity.
Suzuki
N
N
Laboratory of Analytical Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan. n-suzuki@ac.shoyaku.ac.jp
Nakamura
Y
Y
Watanabe
Y
Y
Kanzaki
Y
Y
D000538:Aluminum Silicates / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000737:chemistry; D004008:Diclofenac / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D010713:Phosphatidylcholines / Q000737:chemistry; D013818:Thermogravimetry; D017155:Wettability; D014961:X-Ray Diffraction
D000538:Aluminum Silicates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D010713:Phosphatidylcholines; D004008:Diclofenac; C011934:mica