Enhanced expression of I-kappaB with neurofibrillary pathology in Alzheimer's disease.
Inflammatory and immune responses are known to be involved in the pathogenesis of Alzheimer's disease (AD). NF-kappaB is a major transcription factor that plays a central role in the inflammatory and immune responses and is regulated by I-kappaB through an autoregulatory feedback system. Southwestern immunohistochemistry and immunohistochemistry in our study demonstrated activated NF-kappaB in AD brains. However, there was also activated expression of I-kappaB in a distribution that corresponded to the neurofibrillary pathology of AD. These observations indicate that disruption of the autoregulatory mechanism of NF-kappaB in brain regions with neurofibrillary pathology may play a role in the pathogenesis of AD.
Yoshiyama
Y
Y
Department of Neurology, School of Medicine, Chiba University, Japan.
Arai
K
K
Hattori
T
T
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001923:Brain Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D016874:Neurofibrillary Tangles / Q000378:metabolism* / Q000473:pathology*; D009474:Neurons / Q000378:metabolism / Q000473:pathology
D020672:I-kappa B Proteins; D016328:NF-kappa B