Effects of a novel potential antidepressant on the behavior and cortisol levels of isolated guinea pig pups.
A novel, potential antidepressant, E-6006 citrate (E-6039), dose-dependently reduced the vocalizations emitted by isolated guinea pig pups. The (+)-E-6006, but not the (-)-E-6006, enantiomer also reduced vocalizing. There were no reliable effects of E-6039 on locomotor activity, crouching, or other behavioral measures, but both E-6039 and the (+)-E-6006 enantiomer elevated plasma cortisol levels during isolation. The contrasting effects of E-6039 on vocalizations and plasma cortisol are discussed in terms of E-6039's putative ability to inhibit release of substance P. The reduction in the vocalizations of isolated guinea pig pups corroborates positive results with this drug in other antidepressant screens utilizing mice and rats, and provides further support for the potential of E-6039 as an antidepressant compound.
Hennessy
M B
MB
Department of Psychology, Wright State University, Dayton, OH 45435, USA. michael.hennessy@wright.edu
Pitstick
L
L
O'Leary
S
S
Maken
D S
DS
Farré
A J
AJ
D000818:Animals; D000831:Animals, Newborn; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology; D012934:Social Isolation; D014828:Vocalization, Animal / Q000187:drug effects* / Q000502:physiology
C427705:5-(alpha-(2-(dimethylamino)ethoxy)-2-thienylmethyl)-1-methyl-1H-pyrazole; D000928:Antidepressive Agents; D011720:Pyrazoles; D006854:Hydrocortisone