Neurofibromatosis type 1 presenting with hand dystonia.
Neurofibromatosis type 1 is frequently associated with increased intensity T2-weighted magnetic resonance imaging (MRI) brain abnormalities, called "unidentified bright objects." Unidentified bright objects are generally held to be benign and tend to decrease in size during adulthood. We describe a case of neurofibromatosis type 1 with a similar thalamic and subthalamic MRI abnormality associated with contralateral hand dystonia. Over a 2-year follow-up, the lesions showed a reduction in size apparently correlated with a reduction in symptoms.
Di Capua
M
M
Department of Neurology, Bambino Gesù Children's Hospital, National Medical Research Institute, Rome, Italy. dicapua@opbg.net
Lispi
M L
ML
Giannotti
A
A
Longo
D
D
Fariello
G
G
D000293:Adolescent; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D004421:Dystonia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006225:Hand / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009456:Neurofibromatosis 1 / Q000150:complications / Q000175:diagnosis*