Glycobiology of Plasmodium falciparum.
The human malaria parasite, Plasmodium falciparum, has as its only glycoconjugate GPI anchors. These structures, present in essentially all parasite surface proteins, are associated with disease pathology. In contrast, the parasite depends for essential recognition events on saccharides associated with host cell glycoproteins and proteoglycans.
Davidson
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Department of Biochemistry and Molecular Biology, Georgetown University, Washington, DC, USA. davidson@bc.georgetown.edu
Gowda
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D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry*; D017261:Glycosylphosphatidylinositols / Q000096:biosynthesis / Q000737:chemistry*; D008358:Mannose / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000378:metabolism
D002352:Carrier Proteins; D006023:Glycoproteins; D017261:Glycosylphosphatidylinositols; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; C055213:saccharide-binding proteins; D008358:Mannose