[Laboratory investigation on M-protein and its clinical application. 1. Introduction].
Monoclonal protein is the immunoglobulin and its fragments which are originated from a monoclonal clone of immunoglobulin synthesizing cell. It is an actually tumour marker for B cell lymphoproliferative disorders. It is also observed in non-lymphoproliferative disorders such as solid tumor, infection, and immunodeficiencies. Monoclonal gammopathy of undetermined significance(MGUS) can be defined as a state of pre-malignancies, especially development of myeloma should be carefully followed. The paper outlines a routine-based laboratory approach on monoclonal protein in relevance with its classification, laboratory methods and the related diseases, thus giving general orientations for the paper followed.
Itoh
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Department of Laboratory Medicine, Asahikawa Medical Collage, Asahikawa 078-8510.
D001402:B-Lymphocytes; D001536:Bence Jones Protein / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D006362:Heavy Chain Disease / Q000175:diagnosis; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000175:diagnosis; D010266:Paraproteins / Q000032:analysis* / Q000145:classification
D015415:Biomarkers; D010266:Paraproteins; D001536:Bence Jones Protein