title: [Doksazozin "Cardura" in acute urinary retention caused by benign prostatic hyperplasia].
abstract: Drug treatment of acute ischuria (AI) caused by benign prostatic hyperplasia (BPH) is discussed. Catheterization of the urinary bladder is the main treatment for AI. AI is caused by anatomical obstruction, hypertone of smooth myocytes, and energy imbalance of detrusor. Use of alpha 1-adrenoblockers in AI is pathogenetically justified, as the development of stable spasm of smooth-muscle structures of the prostate, vesical cervix, and prostatic compartment of the urethra resultant from increased functional activity of alpha 1-adrenoreceptors underlies the dynamic component of obstruction. alpha 1-Adrenoblocker doxazosin (cardura) was used for arresting AI caused by BPH after 12-h randomization and catheterization of the bladder. A prospective randomized placebo-controlled study was carried out on 36 patients. Spontaneous urination was restored in 55.5% patients, in 63.3% of these after doxazosin and in 16.6% after placebo. 37.9% of patients from the doxazosin group were discharged from hospital for outpatient therapy with alpha-blockers and the rest were operated on. Hence, doxazosin increases the chance of recovery of spontaneous urination for patients with AI caused by BPH and allows time and conditions for preparation of patients to surgery. Therapy with alpha 1-adrenoblockers after resolution of AI in patients with BPH can be effective and should be further investigated.
authors.forename: T S
authors.initials: TS
authors.lastname: Perepanova
authors.forename: A A
authors.initials: AA
authors.lastname: Kamalov
authors.forename: V N
authors.initials: VN
authors.lastname: Siniukhin
authors.forename: A V
authors.initials: AV
authors.lastname: Gorokhnov
authors.forename: P L
authors.initials: PL
authors.lastname: Khazan
authors.forename: E V
authors.initials: EV
authors.lastname: Orlova
mesh_terms: D000208:Acute Disease; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000368:Aged; D017292:Doxazosin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000150:complications*; D016055:Urinary Retention / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D017292:Doxazosin
vernacular_title: Doksazozin "Kardura" pri ostroĭ zaderzhke mocheispuskaniia, obuslovlennoĭ dobrokachestvennoĭ giperplazieĭ prostaty.