Genomic and proteomic databases: large-scale analysis and integration of data.
With the completion of the human genome draft sequencing and assembly, an upcoming targeted goal will be identifying the proteins and changes in protein expression, which are derived from the genome template. There is important information already available on many proteins that can be a valuable resource to scientists in cardiovascular medicine as well as other fields. This article will summarize many of the different databases, their content and growth, and the differences between growth of nucleic acid and protein databases. Linkage between and integration of different protein and nuclei acid databases, along with related annotation, will greatly improve the information content and knowledge base with regards to protein data.
Cavalcoli
J D
JD
Laboratory for Molecular Genetics, Alameda Laboratories, Pfizer Global Research & Development, Alameda, CA, USA. james.cavalcoli@pfizer.com
D016208:Databases, Factual; D016678:Genome; D006801:Humans; D009696:Nucleic Acids / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D011506:Proteins / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D020543:Proteome / Q000032:analysis / Q000502:physiology*; D017422:Sequence Analysis, DNA / Q000379:methods / Q000639:trends; D020539:Sequence Analysis, Protein / Q000379:methods / Q000639:trends; D017423:Sequence Analysis, RNA / Q000379:methods / Q000639:trends; D013223:Statistics as Topic / Q000379:methods / Q000639:trends
D009696:Nucleic Acids; D011506:Proteins; D020543:Proteome