[Leptin: factor in the central nervous system regulation of bone mass. Development of a new understanding of bone remodeling, skeletal reconstruction, skeletal preservation and skeletal repair].
Bone remodeling is the physiologic process used by vertebrates to maintain a constant bone mass between the end of puberty and gonadal failure. Besides the well-characterized and critical local regulation of bone remodeling, recent genetic studies have shown that there is a central control of bone formation, one aspect of bone remodeling. This central regulation involves leptin, an adipocyte-secreted hormone that controls body weight, reproduction, and bone remodeling following binding to its receptor located on the hypothalamic nuclei. This genetic result in rodents is in line with clinical observations in humans and offers a whole new direction for research in bone physiology.
Amling
M
M
Abteilung für Unfall- und Wiederherstellungschirurgie, Chirurgische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg. amling@uke.uni-hamburg.de
Schilling
A F
AF
Haberland
M
M
Rueger
J M
JM
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D001835:Body Weight; D015519:Bone Density; D001846:Bone Development; D016723:Bone Remodeling; D001842:Bone and Bones / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology; D005260:Female; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000502:physiology*; D020738:Leptin / Q000502:physiology*; D051379:Mice; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000503:physiopathology*; D051381:Rats; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D012106:Research; D012307:Risk Factors
D002352:Carrier Proteins; C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; C515447:leptin receptor, mouse
Leptin: Faktor in der zentralnervösen Regulation der Knochenmasse. Entwicklung eines neuen Verständnisses von Knochenremodeling, Skelettumbau, Skeletterhaltung und Skelettreparatur.