Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia.
Based on the use of Scutellaria baicalensis for the treatment of stroke in traditional Oriental medicine, the current study was carried out to evaluate neuroprotective effects of S. baicalensis after transient global ischemia using rat 4-vessel occlusion model. Methanol extracts from the dried roots of S. baicalensis (0.1-10 mg/kg) administered intra-peritoneally significantly protected CA1 neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. Methanol extract of S. baicalensis inhibited microglial tumor necrosis factor-alpha (TNF-alpha) and nitric oxide production, and protected PC12 cells from hydrogen peroxide-induced toxicity in vitro.
Kim
Y O
YO
Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyunghee University, 1 Hoegi-dong, Tongdaemun-ku, Seoul 130-701, Republic of Korea.
Leem
K
K
Park
J
J
Lee
P
P
Ahn
D K
DK
Lee
B C
BC
Park
H K
HK
Suk
K
K
Kim
S Y
SY
Kim
H
H
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000517:prevention & control*; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000627:therapeutic use*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D008297:Male; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D047310:Apigenin
D044950:Flavanones; D005419:Flavonoids; D018696:Neuroprotective Agents; D009569:Nitric Oxide; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C458179:scutellarein; D047310:Apigenin