A comparative study of toxocariasis and allergic asthma in murine models.
Histopathology of the lung and total IgE in serum were compared in toxocariasis and allergic asthma murine models using BALB/c and C57BL/6 mice. Infection with Toxocara canis resulted in both strains of mice in marked histological changes and increased levels of total serum IgE. The ovalbumin (OVA) sensitization/challenge treatment for the induction of allergic asthma resulted in similar histological changes in BALB/c and, to a less extent, in C57BL/6 mice. Serum IgE levels of OVA-treated C57BL/6 mice were low. Histological changes observed included perivascular infiltration with eosinophils and mononuclear cells, peribronchiolitis, alveolitis and mucus production. Although these changes in addition to increased IgE production did occur in T. canis-infected C57BL/6 mice they were more pronounced in BALB/c mice. Thus, BALB/c mice appear to be the most appropriate strain of mice to perform studies on the possible connection between infection with T. canis and allergic asthma.
Pinelli
E
E
Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthhoven, The Netherlands. elena.pinelli@rivm.nl
Dormans
J
J
Fonville
M
M
van der Giessen
J
J
D000818:Animals; D001249:Asthma / Q000378:metabolism* / Q000469:parasitology; D001985:Bronchial Provocation Tests / Q000379:methods; D004804:Eosinophils / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D010047:Ovalbumin / Q000009:adverse effects; D017166:Toxocara canis; D014120:Toxocariasis / Q000378:metabolism* / Q000469:parasitology
D007073:Immunoglobulin E; D010047:Ovalbumin