Facile synthesis and biological evaluation of heterocyclic compounds containing diazepam.
Diazepamoxadiazoles 4, 5, 6, 12, 14 and 22 were prepared with the binary form system. Diazepamthiadiazoles 15, 20 and Diazepamtriazoles 7, 8, 9, 17, 18, 19 and 21 were also shapely synthesized. Some of these compounds were screened to test their antibacterial activity against E. coli and B. subtilis compounds 15 and 20 show potent activity against these bacteria.
Berghot
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Department of Chemistry, Faculty of Science, Mansoura University, Egypt. dal-mag@hotmail.com
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D003975:Diazepam / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D004926:Escherichia coli / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D003975:Diazepam