title: Chronic myeloid leukemia with a rare variant Philadelphia translocation: t(9;10;22)(q34;q22;q11).
abstract: We report a 59-year-old, male, chronic myeloid leukemia patient with a rare variant Philadelphia (Ph) translocation t(9;10;22)(q34;q22;q11). Fluorescence in situ hybridization with whole chromosome paints was used to confirm the cytogenetic findings. With a BCR/ABL-specific probe, the known rearrangement on the derivative chromosome 22 was found. The prognostic implications as well as the relevance of the additional breakpoint region 10q22 are discussed.
authors.affiliation: Institute of Medical Biology and Human Genetics, University of Graz, Harrochgasse 21/8, A-8010 Graz, Austria. werner.emberger@kfunigraz.ac.at
authors.forename: W
authors.initials: W
authors.lastname: Emberger
authors.forename: A
authors.initials: A
authors.lastname: Behmel
authors.forename: M
authors.initials: M
authors.lastname: Tschernigg
authors.forename: H L
authors.initials: HL
authors.lastname: Seewann
authors.forename: E
authors.initials: E
authors.lastname: Petek
authors.forename: P M
authors.initials: PM
authors.lastname: Kroisel
authors.forename: K
authors.initials: K
authors.lastname: Wagner
mesh_terms: D002879:Chromosomes, Human, Pair 10; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic