No linkage or association of the nitric oxide synthase genes to multiple sclerosis.
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of unknown etiology. Nitric oxide (NO) is a free radical that participates in a variety of biological processes. It is an important mediator in the immune response. Several studies indicate involvement of NO in the pathogenesis of MS. We studied five markers within the three NO synthase genes with regards to susceptibility and disease course in 156 affected sib-pairs and in 96 "benign" and 96 "severe" definite MS patients and 148 controls. We found no significant association or evidence for linkage in our data sets.
Modin
H
H
Department of Neurology, R54, Karolinska Institutet, Huddinge University Hospital, S-121 86, Huddinge, Sweden. Helena.Modin@Neurotec.ki.se
Dai
Y
Y
Masterman
T
T
Svejgaard
A
A
Sørensen
P S
PS
Oturai
A
A
Ryder
L P
LP
Spurkland
A
A
Vartdal
F
F
Laaksonen
M
M
Sandberg-Wollheim
M
M
Myhr
K M
KM
Nyland
H
H
Hillert
J
J
D016022:Case-Control Studies; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics* / Q000503:physiopathology; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D010641:Phenotype; D012016:Reference Values; D012720:Severity of Illness Index
D005819:Genetic Markers; C496320:NOS1 protein, human; C496319:NOS2 protein, human; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III