Pharmacological aversion treatment of alcohol dependence. I. Production and prediction of conditioned alcohol aversion.
Eighty-two hospitalized alcoholics receiving pharmacological aversion therapy (PAT) over a 10-day treatment interval completed cognitive, behavioral, and psychophysiological measures evaluating conditioned aversion to alcohol. Pre-post assessments provided convergent support for the efficacy of PAT vis-à-vis production of conditioned aversion to alcohol. Positive alcohol-related outcome expectancies were significantly reduced, whereas confidence that drinking could be avoided in various high-risk situations for consumption was increased following PAT. Behavioral and cardiac rate assessments revealed significant changes following PAT that were specific to alcoholic beverages and potentially reflective of conditioned alcohol aversion. Patients with more extensive pretreatment experiences with alcohol-associated nausea and greater involvement in antisocial conduct appeared to be less susceptible to the PAT conditioning protocol.
Howard
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Department of Psychiatric Epidemiology and George Warren Brown School of Social Work, Washington University, St Louis, Missouri 63130-4899, USA. howard@gwbmail.wustl.edu
D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects* / Q000627:therapeutic use*; D000437:Alcoholism / Q000188:drug therapy* / Q000523:psychology; D000704:Analysis of Variance; D001348:Aversive Therapy / Q000379:methods*; D003214:Conditioning, Classical / Q000187:drug effects*; D004639:Emetics / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009325:Nausea / Q000139:chemically induced / Q000523:psychology; D014839:Vomiting / Q000139:chemically induced / Q000523:psychology
D000427:Alcohol Deterrents; D004639:Emetics