[Multiple organ failure as a manifestation of immune dysregulation of reparative processes in the organs during critical states].
The authors claim that the specific clinical symptoms of multiple organ failure (MOF) are explained by impaired interactions of two functionally related systems: the immune system (IS) responsible for regeneration and the reticuloendothelial system (RES) responsible for inflammation. Organ regeneration during MOF is suppressed as a result of suppressed morphogenetic function of lymphocytes, imbalanced macrophage-lymphocyte interactions, and RES hyperactivation. For prevention and treatment of MOF, the authors recommend stimulation of reparative processes in the organs by splenic therapy: assisted xenospleen, infusion of splenic perfusate or xenosplenic peptides. Xenospleen therapy is preferable to other methods of immunocorrection due to more expressed morphogenetic activity of splenic T lymphocytes and their cytokines.
Onishchenko
N A
NA
Suskova
V S
VS
Tsypin
A B
AB
Marenshaov
A M
AM
Ermakova
L P
LP
D000818:Animals; D002478:Cells, Cultured; D016638:Critical Illness; D016207:Cytokines / Q000502:physiology; D006464:Hemoperfusion; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007167:Immunotherapy; D007249:Inflammation; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D009102:Multiple Organ Failure / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D051381:Rats; D012038:Regeneration; D013154:Spleen / Q000166:cytology / Q000502:physiology / Q000637:transplantation; D013997:Time Factors
D016207:Cytokines
Poliorgannaia nedostatochnost' kak proiavlenie immunnoĭ disreguliatsii reparativnykh protsessov v organakh pri kriticheskikh sostoianiiakh.