title: Systemic lupus erythematosus and thrombotic thrombocytopenic purpura: a case and review.
abstract: Thrombotic thrombocytopenic purpura (TTP) is rare in children with systemic lupus erythematosus (SLE). We report a 15-year-old female who simultaneously presented with TTP and SLE. Kidney biopsy showed membranous nephropathy. Her condition improved with plasmapheresis, intravenous cyclophosphamide, and prednisone pulse therapy. We also reviewed the literature for this association in pediatric patients comparing presenting sequence and renal pathology with cases documented in the adult literature.
authors.affiliation: Department of Pediatrics, University of South Carolina School of Medicine, Columbia, USA. abdullahsakarcan@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Sakarcan
authors.forename: J
authors.initials: J
authors.lastname: Stallworth
mesh_terms: D000293:Adolescent; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications / Q000473:pathology / Q000628:therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007275:Injections, Intravenous; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000628:therapy; D010956:Plasmapheresis; D011241:Prednisone / Q000627:therapeutic use; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000628:therapy
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011241:Prednisone