title: Lipid profile in the progeny of parents with ischemic heart disease.
abstract: Lipid profile of 50 offsprings of parents with ischemic heart disease and 15 control children aged 5-16 years was studied. The children in both the groups were categorized into 3 sub groups, 5-10, 11-15 & > 15 years. The Serum total cholesterol levels (mean +/- S.D) (in mg/dl) in the test group were 169.8 +/- 15.13, 173.34 +/- 33.56, 177.4 +/- 27.89 respectively for the 3 age subgroups. The Serum LDL cholesterol levels (mean +/- S.D) (in mg/dl) in the test group were 102.2 +/- 15.25, 95.13 +/- 30.38, 101.09 +/- 26.96 respectively. The serum total cholesterol levels (mean +/- S.D) (in mg/dl) in the control group were 123 +/- 1.33, 118 +/- 7.51 and 127.4 +/- 5.77 respectively for the 3 age subgroups. The serum LDL cholesterol levels (mean + S.D) (in mg/dl) in the control group were 56.64 +/- 8.75, 43.36 +/- 6.10 and 45.16 +/- 6.78 respectively. The serum total cholesterol and LDL cholesterol levels in the test group were significantly higher as compared to controls (p > 0.05). Among test subjects, 54% had elevated total cholesterol (> 170 mg/dl) and 38% had elevated LDL cholesterol (> 110 mg/dl). These cases had a significant correlation with elevated parental total cholesterol and LDL cholesterol levels (p > 0.05). Thus, a selective screening of the offsprings of parents with premature ischemic heart disease and hypercholesterolemia is advocated.
authors.affiliation: Department of Pediatrics, Govt. Medical College and New Civil Hospital, Surat, India.
authors.forename: I B
authors.initials: IB
authors.lastname: Parmar
authors.forename: P H
authors.initials: PH
authors.lastname: Singh
authors.forename: V
authors.initials: V
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood* / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood* / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000235:genetics*; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000235:genetics*; D010290:Parents; D011336:Probability; D018570:Risk Assessment; D017678:Sex Distribution; D014280:Triglycerides / Q000032:analysis
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol