Chemokines in patients with ischaemic heart disease and the effect of coronary angioplasty.
Percutaneous coronary transluminal angioplasty (PTCA) may release inflammatory mediators such as chemokines. Monocyte chemoattractant protein-1 (MCP-1) and eotaxin (EOX) are monocyte- and eosinophil-specific chemokines involved in the inflammation and pathogenesis of coronary atherosclerosis. A total of 28 patients undergoing elective PTCA, 20 coronary artery disease (CAD) patients undergoing coronary angiography and 28 healthy controls were studied. In PTCA patients before the procedure, MCP-1 plasma levels (441+/-64 pg/ml) were similar to those of CAD patients (430+/-24 pg/ml), and significantly higher compared with controls (145+/-17 pg/ml, P<0.01). MCP-1 rose significantly after 3 and 6 months following PTCA (696+/-89 and 876+/-86 pg/ml, respectively, P<0.01 vs. before PTCA). EOX plasma levels (155+/-14 pg/ml) were similar to those of CAD patients (157+/-14 pg/ml), but significantly higher compared with controls (83.2+/-10 pg/ml, P<0.05). EOX rose significantly 24 h (273+/-41 pg/ml, P<0.05) but not 3 months after PTCA (160+/-20 and 158+/-19 pg/ml, respectively). These findings indicate that chemokine-induced monocyte- and eosinophil-specific chemoattraction is stimulated in patients with coronary artery disease. MCP-1 levels remain significantly elevated for at least 6 months following elective PTCA, suggesting an inflammatory stimulation.
Economou
E
E
Cardiology Unit, Athens University Medical School, Hippokration Hospital, 114 Vasillisis Sofias, 11528, Athens, Greece.
Tousoulis
D
D
Katinioti
A
A
Stefanadis
C
C
Trikas
A
A
Pitsavos
C
C
Tentolouris
C
C
Toutouza
M G
MG
Toutouzas
P
P
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D016022:Case-Control Studies; D054413:Chemokine CCL11; D018932:Chemokine CCL2 / Q000097:blood*; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000276:immunology / Q000628:therapy*; D018709:Statistics, Nonparametric; D015854:Up-Regulation
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D018932:Chemokine CCL2; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil; D016207:Cytokines