title: Meningeal Rosai-Dorfman disease: report of three cases and literature review.
abstract: Rosai-Dorfman disease is a well-recognized clinicopathological entity, which in rare cases affects the central nervous system, where it mimics meningioma. We describe three cases and review the literature. Histological and immunohistochemical confirmation is essential for definitive diagnosis. In addition to emperipolesis (lymphophagocytosis), reactivity for S-100 and CD68 and nonreactivity for CD-la immunostaining are characteristic features of this histioproliferative disease. In contrast to meningioma, this tumor usually occurs in young males and infiltrates the brain parenchyma.
authors.affiliation: Department of Neurosurgery, Fukui Medical School, Matsuoka Yoshida, Japan. kitai@fmsrsa.fukui-med.ac.jp
authors.forename: R
authors.initials: R
authors.lastname: Kitai
authors.forename: J
authors.initials: J
authors.lastname: Llena
authors.forename: A
authors.initials: A
authors.lastname: Hirano
authors.forename: K
authors.initials: K
authors.lastname: Ido
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Kubota
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis; D008578:Meninges / Q000473:pathology*; D008579:Meningioma / Q000175:diagnosis