Suppressive effect of aspirin on chromosome aberration induced by mitomycin C in mice.
Chromosome aberrations induced by mitomycin C (MMC) were suppressed by aspirin in a mouse micronucleus test with peripheral blood and bone marrow cells. Aspirin at doses of 0.5, 5, and 50 mg/kg was injected intraperitoneally or per administered orally 0.5, 6, or 24 h after administration of MMC and then peripheral blood and/or bone marrow cells were sampled 48 h after administration of MMC. The suppressive effect of aspirin was more pronounced in the aspirin-treated groups 24 h than 0.5 and 6 h after administration of MMC. In the aspirin-treated group at 24 h, the frequency of polychromatic erythrocytes with micronuclei was decreased by about 60-80% after intraperitoneal injection and by about 40-70% after oral administration. It is suggested that aspirin may directly act on MMC metabolites, but not on MMC itself.
Niikawa
M
M
Ichinomiya Women's Junior College, Japan.
Nakamura
T
T
Nagase
H
H
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001219:Aspartate Aminotransferases / Q000097:blood; D001241:Aspirin / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004912:Erythrocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015162:Micronucleus Tests; D016685:Mitomycin / Q000037:antagonists & inhibitors* / Q000633:toxicity
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001241:Aspirin