Pancreatic arterial calcium stimulation in the diagnosis and localisation of persistent hyperinsulinemic hypoglycaemia of infancy.
BACKGROUND
Persistent hyperinsulinemic hypoglycaemia of infancy (PHHI) is often resistant to medical therapy. Surgery is therefore necessary. It is due to focal adenomatous islet-cell hyperplasia treatable by partial pancreatectomy, or diffuse beta-cell hyperfunction, which requires near-total pancreatectomy. Pancreatic venous sampling (PVS) is the reference technique for the preoperative diagnosis and localization of focal forms of PHHI in the pancreas. However, hypoglycaemia is necessary to analyse the results and PVS is technically challenging. Pancreatic arterial calcium stimulation (PACS) is technically easier and does not require hypoglycaemia.


OBJECTIVE
To study the accuracy in the diagnosis and localization of PHHI.


METHODS
PACS was performed in 12 patients and correlated with histology.


RESULTS
The accuracy of PACS is poor in diffuse lesions since only two of six cases were correctly identified by this test. Five of six focal lesions were correctly recognized and located.


CONCLUSIONS
PACS is less accurate than PVS in PHHI. Currently, it should be performed only when PVS fails.
Chigot
V
V
Department of Radiology, Hôpital des Enfants Malades, 149 rue de Sèvres, 75 015 Paris, France. valeriechigot@aol.com
De Lonlay
P
P
Nassogne
M C
MC
Laborde
K
K
Delagne
V
V
Fournet
J C
JC
Nihoul-Fékété
C
C
Saudubray
J M
JM
Brunelle
F
F
D002118:Calcium; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology*; D007003:Hypoglycemia / Q000209:etiology*; D007223:Infant; D007515:Islets of Langerhans / Q000473:pathology*; D008297:Male; D010180:Pancreatectomy; D010182:Pancreatic Diseases / Q000150:complications / Q000175:diagnosis* / Q000601:surgery
D002118:Calcium