Histologic evaluation of the osteoinductive property of autogenous demineralized dentin matrix on surgical bone defects in rabbit skulls using human amniotic membrane for guided bone regeneration.
The aim of this investigation was to evaluate the osteoinductive property of autogenous demineralized dentin matrix (ADDM) on experimental surgical bone defects in the parietal bone of rabbits using the guided bone regeneration (GBR) technique incorporating human amniotic membrane (HAM). Thirty-six rabbits were divided into 2 groups, HAM and ADDM+HAM. It was possible to conclude that HAM did not interfere with bone repair and was resorbed. Slices of ADDM induced direct bone formation and were incorporated by the newly formed bone tissue and remodeled. The bone defects healed faster in the ADDM+HAM group than in the group with HAM only.
Gomes
M F
MF
Department of Biopathology and Diagnosis, São José dos Campos Dental School, São Paulo State University, UNESP, Brazil. mfgomes@fosjc.unesp.br
dos Anjos
M J
MJ
Nogueira
T O
TO
Guimarães
S A
SA
D020341:Absorbable Implants; D000650:Amnion; D000818:Animals; D001847:Bone Diseases / Q000473:pathology / Q000601:surgery*; D001861:Bone Regeneration / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D004396:Coloring Agents; D003764:Dental Materials / Q000627:therapeutic use*; D003804:Dentin; D005500:Follow-Up Studies; D006801:Humans; D008567:Membranes, Artificial; D010012:Osteogenesis / Q000502:physiology*; D010294:Parietal Bone / Q000473:pathology / Q000601:surgery*; D011817:Rabbits; D014182:Transplantation, Autologous; D014945:Wound Healing
D018786:Bone Substitutes; D004396:Coloring Agents; C093073:Demineralized Dentin Matrix; D003764:Dental Materials; D008567:Membranes, Artificial