[Vestibular and oculomotor changes in subjects treated with cisplatin].
Cisplatin is an agent used in the treatment of distinct oncologic diseases. We present the electrooculographic (EOG) findings of 6 patients which were seen at our Department under the diagnosis of chronic toxicity for cisplatin and associated vestibular alterations. Mean of age was 45 years. Three subjects were female (50%). The most frequent pathologic finding was ataxic pursuit tracking (100%). Additionally, spontaneous nystagmus, alterations in positional test, and vestibulo-ocular reflex suppression were also found. These results are discussed and the main literature concerning this matter is reviewed.
Prim
M P
MP
Servicio de Otorrinolaringología, Hospital Universitario La Paz, Universidad Autónoma de Madrid. jidediegompprim@retemail.es
de Diego
J I
JI
de Sarriá
M J
MJ
Gavilán
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017120:Nystagmus, Optokinetic; D009759:Nystagmus, Pathologic / Q000139:chemically induced / Q000175:diagnosis; D015840:Oculomotor Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D012021:Reflex, Abnormal / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D012189:Retrospective Studies; D012438:Saccades / Q000502:physiology; D015837:Vestibular Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology
D000970:Antineoplastic Agents; D002945:Cisplatin
Alteraciones vestibulares y del sistema oculomotor en sujetos tratados con cisplatino.