The importance of being cleaved: an essential step in killing by enzymatic colicins.
In this issue, de Zamaroczy et al. show that cleavage of the bacterial toxin colicin D is required for its ability to kill cells. Surprisingly, the cleavage requires the inner membrane peptidase LepB that normally functions in protein secretion.
Jakes
K S
KS
Department of Physiology and Biophysics, Albert Einstein College of Medicine, 10461, Bronx, NY, USA.
D001426:Bacterial Proteins / Q000378:metabolism; D016923:Cell Death / Q000502:physiology*; D003087:Colicins / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000502:physiology*; D008565:Membrane Proteins; D008954:Models, Biological; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D003087:Colicins; D008565:Membrane Proteins; D012697:Serine Endopeptidases; C026515:type I signal peptidase