title: The concentrations of osteocalcin and degradation products of type I collagen in pregnant women with pre-eclampsia.
abstract: OBJECTIVE
  To investigate the concentrations of osteocalcin and collagen type I C-terminal telopeptides in pregnant women with pre-eclampsia.
  
  
  METHODS
  26 patients with severe pre-eclampsia and 24 healthy pregnant women were included in the study. Serum concentrations of osteocalcin and C-telopeptides--degradation products of type I collagen were determined using the ELISA method. Statistical analysis was performed using Mann-Whitney U-test.
  
  
  RESULTS
  In pre-eclamptic patients, the concentrations of osteocalcin and degradation products of collagen type I were significantly higher (P<0.005) when compared to healthy pregnant women.
  
  
  CONCLUSIONS
  These results could suggest that there are alterations in bone metabolism in pregnant women with pre-eclampsia.
authors.affiliation: Department of Orthopedics, University School of Medicine, Jaczewskigo 8, 20-950, Lublin, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Gorzelak
authors.forename: D
authors.initials: D
authors.lastname: Darmochwal-Kolarz
authors.forename: M
authors.initials: M
authors.lastname: Jablonski
authors.forename: J
authors.initials: J
authors.lastname: Rolinski
authors.forename: B
authors.initials: B
authors.lastname: Leszczynska-Gorzelak
authors.forename: K
authors.initials: K
authors.lastname: Modrzewski
authors.forename: J
authors.initials: J
authors.lastname: Oleszczuk
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000378:metabolism; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015675:Osteocalcin / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012016:Reference Values
chemical_list: D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003094:Collagen