[Radiation-induced cataract: physiopathologic, radiobiologic and clinical aspects].
Cataractogenesis is a widely reported late effect of irradiated crystalline lens. In this review the authors discussed the different aspects of radiation cataract pathogenesis, and the different mechanisms involved in the lens opacification, particularly the epithelium modifications such as epithelial cell death. The authors also reported the influence of radiation exposure on cataract formation following total body irradiation (TBI) and autologous or allogeneic bone marrow transplantation for hematologic malignancies. Moreover, the radiobiological parameters are not studied for the crystalline lens of human. We applied for the first time the linear-quadratic (LQ) and biological effective dose (BED) concept to TBI data. The calculated value of alpha/beta of 1 Gy is in the range of the values reported for the other late responding tissues. The other risk factors for cataract development after TBI such as age, gender, central nervous system boost, long-term steroid therapy and heparin administration are discussed. In terms of cataract or sicca syndrome prevention, numerous compounds have been successfully tested in experimental models or used for the prevention of radiation-induced xerostomia in patients treated for head and neck cancer. However, none of them has been clinically evaluated for ocular radiation late effects prevention. In this report the authors discussed some of the radioprotectors potentially interesting for radiation-induced cataract or sicca syndrome prevention.
Belkacémi
Y
Y
Laboratoire de toxicologie, UFR pharmacie, université Paris V. Unité de pharmacotoxicologie cellulaire, service pharmacie, 75012 Paris, France. yazid.belkacemi@tnn.ap-hop-paris.fr
Touboul
E
E
Méric
J B
JB
Rat
P
P
Warnet
J M
JM
D000367:Age Factors; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D000925:Anticoagulants / Q000009:adverse effects; D000975:Antioxidants / Q000378:metabolism; D002386:Cataract / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D002417:Cattle; D004195:Disease Models, Animal; D019583:Dose Fractionation, Radiation; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D016014:Linear Models; D008297:Male; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D011878:Radiotherapy / Q000009:adverse effects*; D012307:Risk Factors; D012737:Sex Factors; D012859:Sjogren's Syndrome / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D013256:Steroids; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000975:Antioxidants; D011837:Radiation-Protective Agents; D013256:Steroids; D006493:Heparin; D005978:Glutathione
Cataracte radio-induite: aspects physiopathologiques, radiobiologiques et cliniques.