title: Early binocular visual experience may improve binocular sensory outcomes in children after surgery for congenital unilateral cataract.
abstract: OBJECTIVE
  To compare the effect of intensive and reduced occlusion therapy regimens on binocular sensory outcomes, visual acuity, and the prevalence of strabismus in children after surgery for congenital unilateral cataract.
  
  
  METHODS
  Two nonrandomized groups of patients were studied prospectively: (1) an intensive occlusion group (n = 29) patched 80% of waking hours were followed for a median 6.9 years and (2) a reduced occlusion group (n = 8) patched 25% to 50% of waking hours were followed for a median 4.3 years. Six subjects in the intensive group and 4 in the reduced occlusion group had secondary intraocular lenses. Two subjects in the intensive group had epikeratophakia surgery. Binocular sensory function was assessed with random dot and contour stereoacuity tests and the Worth 4-dot test. The prevalence and age at onset of strabismus were determined from the patients' charts.
  
  
  RESULTS
  A higher proportion of subjects in the reduced occlusion group (50%) had stereoacuity or fusion compared with the intensive occlusion group (14%), a borderline significant difference (P =.08). No significant difference (P =.55) was found in median visual acuity between the intensive (20/50) and the reduced occlusion (20/55) groups. The 90% prevalence of strabismus in the intensive occlusion group was slightly higher than the 63% prevalence in the reduced occlusion group, although this difference was not significant (P =.18).
  
  
  CONCLUSIONS
  These results suggest that a reduced occlusion protocol may be associated with better binocular sensory outcomes and a reduced prevalence of strabismus without compromising good visual acuity in children treated for congenital unilateral cataract.
authors.affiliation: Retina Foundation of the Southwest, Dallas, Texas 75231, USA. bjeffrey@retinafoundation.org
authors.forename: B G
authors.initials: BG
authors.lastname: Jeffrey
authors.forename: E E
authors.initials: EE
authors.lastname: Birch
authors.forename: D R
authors.initials: DR
authors.lastname: Stager
authors.forename: D R
authors.initials: DR
authors.lastname: Stager
authors.forename: D R
authors.initials: DR
authors.lastname: Weakley
mesh_terms: D002386:Cataract / Q000151:congenital* / Q000503:physiopathology; D002387:Cataract Extraction; D002675:Child, Preschool; D003261:Contact Lenses; D003867:Depth Perception / Q000502:physiology; D005139:Eyeglasses; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D011446:Prospective Studies; D012683:Sensory Deprivation; D013285:Strabismus / Q000517:prevention & control*; D015348:Vision, Binocular / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology*