title: Osseointegrated implants in patients treated for generalized chronic periodontitis and generalized aggressive periodontitis: 3- and 5-year results of a prospective long-term study.
abstract: BACKGROUND
  The successful use of osseointegrated implants in periodontally healthy patients has been documented in numerous longitudinal studies in recent years. However, the extent to which these positive results apply to periodontally diseased patients remains unclear. The aim of the present prospective longitudinal study of partially edentulous patients treated for generalized chronic periodontitis and generalized aggressive periodontitis was a clinical, microbiological, and radiographic comparison of teeth and implants and assessment of the implant success rate.
  
  
  METHODS
  Five partially edentulous patients treated for generalized aggressive periodontitis (GAgP) and 5 treated for generalized chronic periodontitis (GCP) were enrolled in this study. The GAgP patients received 36 implants, and the GCP patients 12 implants. The teeth were examined 2 to 4 weeks before extraction of the non-retainable teeth (baseline), and 3 weeks after insertion of the final abutments (second examination). All further examinations were performed during a 3-month recall schedule over a 5-year period for the GAgP patients and over a 3-year period for the GCP patients. At each session clinical parameters were recorded at teeth and implants and the composition of the subgingival microflora was determined by dark-field microscopy and DNA analysis. Intraoral radiographs of the teeth and implants were taken for control purposes at baseline; after insertion of the superstructure; and 1, 3, and 5 years later.
  
  
  RESULTS
  The clinical findings indicated healthy periodontal and peri-implant conditions in both patient groups throughout the study. However, an increased probing depth and an attachment loss were recorded in the GAgP patients after the third year (P<0.001). The distribution of the microorganisms revealed no significant differences between the patient groups or between implants and teeth. Moderate bone loss at teeth and implants was registered in both groups. The success rates recorded were 100% in the GCP patients and 88.8% (maxilla: 85.7%; mandible: 93.3%) in the GAgP patients.
  
  
  CONCLUSIONS
  The 3-year and 5-year follow-ups show that osseointegrated implants may be successful in oral rehabilitation of partially edentulous patients treated for generalized aggressive periodontitis and generalized chronic periodontitis. However, as no significant differences were recorded between conditions at teeth and at implants, progression of the disease cannot be ruled out.
authors.affiliation: Department of Periodontology, School of Dentistry, Philipps University, Marburg, Germany. mengel@mailer.uni-marburg.de
authors.forename: R
authors.initials: R
authors.lastname: Mengel
authors.forename: T
authors.initials: T
authors.lastname: Schröder
authors.forename: L
authors.initials: L
authors.lastname: Flores-de-Jacoby
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000150:complications / Q000382:microbiology; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000209:etiology; D002908:Chronic Disease; D003758:Dental Implantation, Endosseous; D015921:Dental Implants / Q000009:adverse effects; D019232:Dental Restoration Failure; D003830:Denture, Partial, Fixed; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007576:Jaw, Edentulous, Partially / Q000150:complications* / Q000534:rehabilitation* / Q000601:surgery; D016348:Osseointegration; D010512:Periodontal Index; D010518:Periodontitis / Q000150:complications* / Q000382:microbiology; D011446:Prospective Studies; D011859:Radiography; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D015921:Dental Implants