title: Cortical reorganization in patients with high frequency cochlear hearing loss.
abstract: Animal research has shown that tonotopic representation in the auditory cortex is not statically fixed in the adult organism but can be altered after deafferentation. The present study examines the plasticity of the human auditory cortex in patients with high frequency cochlear hearing loss by means of magnetoencephalographic measurements. The data show that the cortical map can reorganize such that cortical neurons deprived of their usual most sensitive afferent input now respond to tone frequencies adjacent to the frequency range of the partial hearing loss. The results suggest that deafferentation due to cochlear damage in adults may lead to functional reorganization of auditory cortical structures.
authors.affiliation: Center of Biomagnetism, Institute of Experimental Audiology, University of Münster, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Dietrich
authors.forename: M
authors.initials: M
authors.lastname: Nieschalk
authors.forename: W
authors.initials: W
authors.lastname: Stoll
authors.forename: R
authors.initials: R
authors.lastname: Rajan
authors.forename: C
authors.initials: C
authors.lastname: Pantev
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001303:Auditory Cortex / Q000503:physiopathology*; D001306:Auditory Pathways / Q000503:physiopathology*; D015834:Cochlear Diseases / Q000503:physiopathology*; D005260:Female; D034381:Hearing Loss / Q000503:physiopathology*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity; D009475:Neurons, Afferent / Q000502:physiology