Flow-injection extraction-spectrophotometric method for the determination of ranitidine in pharmaceutical preparations.
The spectrophotometric determination of trace amounts of ranitidine was carried out by liquid-liquid extraction using bromothymol blue with a flow system. The determination of ranitidine in the range of 1 x 10(-5) - 1 x 10(-4) mol l(-1) was possible with a sampling frequency of 40 samples h(-1). The method was satisfactorily applied to the determination of ranitidine in pharmaceutical preparations and the recovery was quantitative and no interferences from excipients were observed.
Pérez-Ruiz
T
T
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071, Murcia, Spain. tpr@um.es
Martínez-Lozano
C
C
Tomás
V
V
Sanz
A
A
Sahuquillo
E
E
D000897:Anti-Ulcer Agents / Q000032:analysis*; D001979:Bromthymol Blue; D017022:Flow Injection Analysis / Q000295:instrumentation* / Q000379:methods; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011899:Ranitidine / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods; D013678:Technology, Pharmaceutical
D000897:Anti-Ulcer Agents; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D011899:Ranitidine; D001979:Bromthymol Blue