Disturbed benzodiazepine receptor function at the onset of temporal lobe epilepsy--lomanzenil-binding in de-novo TLE.
OBJECTIVE
Epileptogenic foci exhibit disturbed function at the level of the benzodiazepine receptor. The aim of our study was to investigate the incidence of focal reductions of temporal benzodiazepine receptor binding (BRB) as assessed by scintigraphy with 123I-iomazenil in patients with denovo temporal lobe epilepsy (TLE).


METHODS
Forty adult patients (age: 34+/-12 years) with cryptogenic denovo TLE underwent scintigraphy with 123I-iomazenil. In all patients, symptomatic epilepsy was excluded by clinical investigation and MRI. The median duration of TLE was seven months, and the patients had a median of three documented seizures in their history of disease. BRB was quantified in four temporal regions covering the whole temporal lobe. Temporal asymmetry values (ASY) were compared with data determined in 13 age-matched controls yielding Z-scores for global and regional temporal BRB.


RESULTS
A significant reduction of temporal BRB was found in 19 of the 40 patients (48 %), mainly in mesial temporal regions; temporal BRB asymmetries were also found in patients with a short history of seizures and low seizure frequency (< or = 1 year; n = 32, 13/32 (41 %)). Only in the entire cohort did the magnitude of temporal reduction of BRB correlate with the duration of TLE as well as with the number of previous partial seizures (r = 0.40 and r = 0.36; p < 0.03, respectively).


CONCLUSIONS
Foci of decreased BRB can already be detected at the onset of TLE; their magnitude is related to ongoing epileptic activity.
Matheja
P
P
Klinik und Poliklinik für Nuklearmedizin, WWU Muenster, Germany. matheja@uni-muenster.de
Lüdemann
P
P
Kuwert
T
T
Weckesser
M
M
Kellinghaus
C
C
Weitemeyer
L
L
Diehl
B
B
Schuierer
G
G
Ringelstein
E B
EB
Schober
O
O
D000293:Adolescent; D000328:Adult; D001665:Binding Sites; D018450:Disease Progression; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives*; D007839:Functional Laterality; D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D011963:Receptors, GABA-A / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology; D013997:Time Factors
D007457:Iodine Radioisotopes; D011963:Receptors, GABA-A; D005442:Flumazenil; C063038:iomazenil