title: Separase anxiety: dissolving the sister bond and more.
abstract: Separase is a protease that cleaves the bonds between sister chromatids during cell division. Until now, separase was thought to be a somewhat repressed protease, cleaving only a few substrates in a very controlled fashion. New findings in this issue raise the possibility that separase has some of the atavistic impulses that characterize caspases, its more destructive relatives.
authors.affiliation: Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. david_pellman@dfci.harvard.edu
authors.forename: D
authors.initials: D
authors.lastname: Pellman
authors.forename: M F
authors.initials: MF
authors.lastname: Christman
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002455:Cell Division; D002842:Chromatids / Q000235:genetics / Q000378:metabolism*; D010450:Endopeptidases; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D064247:Separase
chemical_list: D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins; D010450:Endopeptidases; C577986:ESP1 protein, S cerevisiae; D064247:Separase