Population genomics: linkage disequilibrium holds the key.
Current efforts to find disease-causing genes depend on patterns of linkage disequilibrium in human populations. Recent work has shown that linkage disequilibrium can extend over much larger genomic regions than expected, and that the patterns of linkage disequilibrium can differ markedly among populations.
Goldstein
D B
DB
Galton Lab, Department of Biology, University College London, 4 Stephenson Way, NW1 2HE, London, UK. d.goldstein@ucl.ac.uk
Weale
M E
ME
D000483:Alleles; D014644:Genetic Variation; D005828:Genetics, Population; D023281:Genomics; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide