title: Improvement in health care utilization and pulmonary function with fluticasone propionate in patients with steroid-dependent asthma at a National Asthma Referral Center.
abstract: The impact of switching from other inhaled corticosteroids to fluticasone propionate was studied in patients with severe oral-steroid-dependent asthma over a 1-year period. In this open-label prospective study, patients on maintenance doses of oral and inhaled steroids were referred to a national asthma treatment center and were switchedfrom their previous inhaled corticosteroid to fluticasone propionate 880 microg BID. Compared with data collected from the year prior to enrollment, treatment with fluticasone propionate resulted in significant improvements in pulmonary function, oral steroid requirements, and health resource utilization. In addition, five patients were completely weaned off oral steroids.
authors.affiliation: National Jewish Medical and Research Center, Denver, Colorado 80206, USA. wenzels@njc.org
authors.forename: S E
authors.initials: SE
authors.lastname: Wenzel
authors.forename: K
authors.initials: K
authors.lastname: Morgan
authors.forename: R
authors.initials: R
authors.lastname: Griffin
authors.forename: R
authors.initials: R
authors.lastname: Stanford
authors.forename: L
authors.initials: L
authors.lastname: Edwards
authors.forename: F S
authors.initials: FS
authors.lastname: Wamboldt
authors.forename: P
authors.initials: P
authors.lastname: Rogenes
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D001249:Asthma / Q000191:economics* / Q000517:prevention & control*; D003120:Colorado; D003365:Costs and Cost Analysis; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital / Q000706:statistics & numerical data*; D011241:Prednisone / Q000008:administration & dosage; D011446:Prospective Studies; D012017:Referral and Consultation; D012129:Respiratory Function Tests; D016896:Treatment Outcome; D014481:United States
chemical_list: D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D000068298:Fluticasone; D011241:Prednisone