A comparison of atenolol, labetalol, esmolol, and landiolol for altering human neutrophil functions.
Neutrophils play a pivotal role in the antibacterial host defense system. Atenolol, labetalol, esmolol, and landiolol at clinically relevant concentrations failed to change neutrophil functions. Our findings indicate that we may be able to use these beta-antagonists without great caution in clinical settings.
Nishina
K
K
Department of Anesthesiology and Intensive Care Unit, Kobe University School of Medicine, Kobe, Japan.
Akamatsu
H
H
Mikawa
K
K
Shiga
M
M
Obara
H
H
Niwa
Y
Y
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D011493:Protein Kinase C / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D009247:NADH, NADPH Oxidoreductases; D011493:Protein Kinase C