[Anti-stress effect of nitric oxide].
Rat strains feature different resistances to stress. The increased production of nitric oxide (NO) in the August strain prevents the appearance of ulcerous lesions of gastric mucosa and behavioral changes induced by restraint stress. Wistar rats feature a lower level of NO production and are more sensitive to restraint stress compared to the August rats according to both the ulcer pathology and behavioral indices. The stress-induced release of catecholamines was reproduced by experimental hyperfunction of the dopaminergic (DA) system induced by the introduction of L-DOPA. Introduction of NO synthase inhibitor N omega-nitro-L-arginine (L-NNA) enhanced the L-DOPA-induced behavioral changes. This effect was more pronounced in the August strain. The introduction of the exogenous NO donor, dinitrosyl iron complexes (DNIC), limited the behavioral disturbances induced by L-DOPA in both rat strains. The protective effect of DNIC in conditions of the DA system hyperfunction is similar to the effect of a D2 blocker sulpiride. Thus, NO has a central antistress effect, apparently, mediated by limiting the release of catecholamines.
Bondarenko
O N
ON
Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Baltiiskaya 8, Moscow, 125315 Russia.
Bondarenko
N A
NA
Malyshev
I Iu
IIu
Manukhina
E B
EB
D000818:Animals; D004198:Disease Susceptibility / Q000378:metabolism; D015259:Dopamine Agents; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects; D007980:Levodopa; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D019335:Nitroarginine / Q000494:pharmacology; D010437:Peptic Ulcer / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013045:Species Specificity; D013312:Stress, Physiological / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology
D015259:Dopamine Agents; D004791:Enzyme Inhibitors; D019335:Nitroarginine; D009569:Nitric Oxide; D007980:Levodopa
Antistressornyĭ éffekt oksida azota.