Inhaled corticosteroids for maintenance treatment in childhood pulmonary sarcoidosis.
We present our experience with sequential oral and inhaled corticosteroid therapy in childhood pulmonary sarcoidosis. Fifteen children were followed-up for a mean of 7 y. Treatment consisted of oral prednisolone 2 mg/kg/d on initial diagnosis. After remission was reached, alternate day therapy with 1 mg/kg was continued. The dose was tapered to a maintenance dose which controlled the activity of the disease. When patients were free of symptoms and had no clinical and laboratory findings, inhaled corticosteriod treatment was started. Relapse treatment consisted of cessation of inhaled corticosteroids and start of oral corticosteroids at a dosage of 2 mg/kg/d and then a tapered dose. Five patients were given oral corticosteroids only. Nine patients were given inhaled steroids after oral corticosteroid therapy had been discontinued. Clinical and radiological remissions were achieved in every patient.


CONCLUSIONS
Sequential oral and inhaled corticosteroid therapy may be an alternative treatment regimen for sarcoidosis in children.
Kiper
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N
Department of Paediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. nkiper@gen.hun.edu.tr
Anadol
D
D
Ozçelik
U
U
Göçmen
A
A
D000280:Administration, Inhalation; D000284:Administration, Oral; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001706:Biopsy / Q000379:methods; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*; D012189:Retrospective Studies; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy*; D015898:Tomography Scanners, X-Ray Computed; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D011239:Prednisolone