title: Airway stability and heterogeneity in the constricted lung.
abstract: The effect of bronchoconstriction on airway resistance is known to be spatially heterogeneous and dependent on tidal volume. We present a model of a single terminal airway that explains these features. The model describes a feedback between flow and airway resistance mediated by parenchymal interdependence and the mechanics of activated smooth muscle. The pressure-tidal volume relationship for a constricted terminal airway is computed and shown to be sigmoidal. Constricted terminal airways are predicted to have two stable states: one effectively open and one nearly closed. We argue that the heterogeneity of whole lung constriction is a consequence of this behavior. Airways are partitioned between the two states to accommodate total flow, and changes in tidal volume and end-expiratory pressure affect the number of airways in each state. Quantitative predictions for whole lung resistance and elastance agree with data from previously published studies on lung impedance.
authors.affiliation: Department of Aerospace Engineering and Mechanics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Anafi
authors.forename: T A
authors.initials: TA
authors.lastname: Wilson
mesh_terms: D000403:Airway Resistance / Q000502:physiology*; D016084:Bronchoconstriction / Q000502:physiology*; D004548:Elasticity; D006801:Humans; D008168:Lung / Q000502:physiology*; D008954:Models, Biological; D011175:Positive-Pressure Respiration; D015656:Respiratory Mechanics / Q000502:physiology; D013990:Tidal Volume / Q000502:physiology