title: Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.
abstract: The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.
authors.affiliation: Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Selva
authors.forename: K
authors.initials: K
authors.lastname: Hong
authors.forename: G H
authors.initials: GH
authors.lastname: Baeg
authors.forename: S M
authors.initials: SM
authors.lastname: Beverley
authors.forename: S J
authors.initials: SJ
authors.lastname: Turco
authors.forename: N
authors.initials: N
authors.lastname: Perrimon
authors.forename: U
authors.initials: U
authors.lastname: Häcker
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000254:growth & development; D004721:Endoplasmic Reticulum / Q000378:metabolism; D016695:Glycosyltransferases / Q000235:genetics / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009024:Morphogenesis; D017351:N-Acetylglucosaminyltransferases; D010641:Phenotype; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology*; D014535:Uridine Diphosphate Glucuronic Acid / Q000378:metabolism; D014537:Uridine Diphosphate N-Acetylglucosamine / Q000378:metabolism; D014540:Uridine Diphosphate Xylose / Q000378:metabolism; D014921:Wings, Animal / Q000196:embryology / Q000254:growth & development
chemical_list: D029721:Drosophila Proteins; D016695:Glycosyltransferases; D006497:Heparan Sulfate; D017351:N-Acetylglucosaminyltransferases; D014535:Uridine Diphosphate Glucuronic Acid; D014537:Uridine Diphosphate N-Acetylglucosamine; D014540:Uridine Diphosphate Xylose; C090576:fng protein, Drosophila