Spontaneous remission in a secondary acute myelogenous leukaemia following invasive pulmonary aspergillosis.
Spontaneous remission of adult acute myelogenous leukaemia (AML) represents a rare event. We report a 60-year-old female patient suffering from secondary AML M1 and severe invasive pulmonary hyalohyphomycosis highly suggestive of aspergillosis. Two months after the diagnosis of leukaemia, she achieved a spontaneous remission lasting 3 months, although neither cytostatic drugs nor corticoids were administered because of a septic condition. At the time of remission, a chronic hepatitis C virus infection and a polyclonal hypergammaglobulinaemia were present, and the patient received granulocyte colony-stimulating factor once. This report represents the first documentation of a spontaneous remission in AML following invasive pulmonary hyalohyphomycosis. Possible mechanisms of this phenomenon are discussed.
Tzankov
A
A
Institute of Pathology, Innsbruck, Austria. alexandar.tzankov@uibk.ac.at
Ludescher
C
C
Duba
H C
HC
Steinlechner
M
M
Knapp
R
R
Schmid
T
T
Grünewald
K
K
Gastl
G
G
Stauder
R
R
D001228:Aspergillosis / Q000150:complications*; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000150:complications*; D008875:Middle Aged; D012075:Remission, Spontaneous; D014057:Tomography, X-Ray Computed