title: Long-term follow-up on use of pericardial graft in the surgical management of Peyronie's disease.
abstract: We have previously reported on the use of Tutoplast cadaveric pericardium as an alternative material for grafting the tunica albugineal defect after Peyronie's plaque excision with satisfactory results in 11 patients. We now review long-term outcomes in this cohort of men. Eleven patients with significant penile curvature interfering with sexual intercourse were evaluated after at least 12 months of conservative therapy. All patients underwent pre-operative evaluation, including penile duplex Doppler ultrasound studies. Chemically processed and gamma-irradiated pericardium (Biodynamics International, Parsippany, NJ) was used to graft the cavernosal defect after surgical excision of the penile plaque. Three patients simultaneously underwent placement of penile prostheses secondary to documented erection problems identified at duplex Doppler ultrasound evaluation. The long-term postoperative complications and erectile function were evaluated with a mean follow-up of 30 months (range 25-35 months). All patients reported resolution of penile curvature allowing for normal sexual function after a mean follow-up of the first 14 months. Thirty months after placement of cadaveric pericardium, the three prosthetic patients still reported excellent sexual function. For the eight patients who did not undergo placement of a prosthesis, three with small to medium plaque size (<2 x 5 cm) continued to do well. The remaining five patients with a large plaque size (>2 x 5 cm) did well initially, but later reported difficulty maintaining erection due to venous leakage, thus they are currently using either a vacuum constriction device or an Actis ring. Three out of these five venous leakage patients had ventral plaques; two had dorsal plaques, one of significant size (4 x 5 cm). We conclude that for those patients who do not undergo placement of a prosthesis, a better long-term outcome is observed when the plaque is small to medium in size (<2 x 5 cm) and dorsally located. Patients with ventral plaque, extreme curvature, or plaque size >4 x 5 cm were more likely to have venoocclusive dysfunction, necessitating further intervention.
authors.affiliation: Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA.
authors.forename: S
authors.initials: S
authors.lastname: Leungwattanakij
authors.forename: T J
authors.initials: TJ
authors.lastname: Bivalacqua
authors.forename: S
authors.initials: S
authors.lastname: Reddy
authors.forename: W J
authors.initials: WJ
authors.lastname: Hellstrom
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003075:Coitus; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010410:Penile Erection; D010411:Penile Induration / Q000503:physiopathology / Q000601:surgery*; D015917:Penile Prosthesis; D010496:Pericardium / Q000637:transplantation*; D016896:Treatment Outcome