[DNA vaccine].
DNA vaccine involves the injection of plasmid DNA encoding an antigen under the control of an eukaryotic promoter, and results in cellular and humoral immune responses to the plasmid DNA-encoded antigen. The immune response induced by DNA vaccine usually has a T-helper-1(Th1) bias through a potent Th1-promoting adjuvant effect of immunostimulatory DNA sequences with CpG motifs present in plasmid DNA. It has been demonstrated that volunteers who were vaccinated with plasmid DNA encoding a malaria protein or a human immunodeficiency virus protein developed antigen-specific, human leukocyte antigen(HLA)-restricted, CD8+ cytotoxic T lymphocytes(CTLs) The demonstration in humans of the induction of CD8+ CTLs by DNA vaccines, including CTLs, provides a foundation for further clinical application of this potentially revolutionary vaccine technology.
Sato
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Y
Department of Internal Medicine II, Fukushima Medical University, School of Medicine, Fukushima 960-1295.
D017951:Antigen Presentation; D001483:Base Sequence; D018899:CpG Islands; D004247:DNA; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism / Q000502:physiology; D010957:Plasmids / Q000235:genetics; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D019444:Vaccines, DNA / Q000627:therapeutic use
D019444:Vaccines, DNA; D018664:Interleukin-12; D004247:DNA