title: Evaluation of polymeric nanoparticles composed of cholic acid and methoxy poly(ethylene glycol).
abstract: Amphiphilic polymeric conjugate based on cholic acid (CA) as the hydrophobic component and methoxy poly(ethylene glycol) (MPEG) as the hydrophilic component was synthesized using a 1,1'-carbonyldiimidazole (CDI) mediated conjugation. Fluorescence spectroscopy measurements suggested that CA and MPEG (abbreviated as CE) conjugate was associated in water to form polymeric core-shell type nanoparticles with a critical association concentration (CAC) value of 0.063 g l(-1). From the transmission electron microscope (TEM) observation, CE nanoparticles were almost spherical with a size range of approximately 10-30 nm in the dried state, which was in agreement with the result from particle size measurement using photon correlation spectroscopy (PCS). Clonazepam (CNZ) was physically loaded into the CE nanoparticles with a 16.2 wt.% loading. CNZ release was pseudo zero-order in kinetic terms for up to 3 days.
authors.affiliation: Department of Biological Chemistry, College of Pharmacy, Chosun University, #375 Seosuk-dong, Dong-gu, Kwangju 501-759, South Korea.
authors.forename: I S
authors.initials: IS
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
mesh_terms: D019826:Cholic Acid; D004337:Drug Carriers / Q000138:chemical synthesis*; D011092:Polyethylene Glycols; D011108:Polymers / Q000138:chemical synthesis*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004337:Drug Carriers; D011108:Polymers; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D019826:Cholic Acid