Serological evidence of brucellosis among predisposed patients with pyrexia of unknown origin in the north eastern Nigeria.
Brucellosis is the zoonosis of world wide distribution and common cause of economic loss and ill health among animals and human populations. Patients with pyrexia of unknown origin (PUO) who were predisposed to brucellosis through rearing of animals and consumption of different animal products were tested for presence of Brucella abortus antibodies using Rose Bengal and serum agglutination antigens. Twenty six (5.2%) of the 500 patients had B. abortus antibody. The high titres of 320, 640 and 1280 obtained in the sera of patients in this study are suggestive of the endemicity of the disease in this environment. No significant difference in age and sex distribution of brucella antibody prevalence was observed. Similarly, spatial distribution of brucella antibody in different locations was not statistically significant. Although higher serological prevalence was noted in children and students than in other populations examined, the difference in prevalence between the various occupational groups was not significant. Animal handling activities including rearing are not important factors in the prevalence of brucellosis. However, among the rearers, the highest prevalence (20%) was observed among cattle handlers followed in decreasing order of prevalence by goat rearers (10%), mixed sheep and cattle rearers (9%), mixed sheep and goat rearers (8%), and 4% among each of sheep rearers and non rearers of animals. In addition, consumers of yoghurt and fresh goat milk had higher prevalence (20%) than consumers of other milk products. However, brucella antibody prevalence between consumers and non-consumers of animal products was not significantly different. The high economic loss and public health implications of brucellosis necessitates the need for effective surveillance as well as appropriate preventive and control measure among human and animal populations.
Baba
M M
MM
Department of Immunology, University of Maiduguri Teaching Hospital, P.M.B. 1414, Maiduguri, Nigeria.
Sarkindared
S E
SE
Brisibe
F
F
D000293:Adolescent; D000328:Adult; D000818:Animals; D000907:Antibodies, Bacterial / Q000302:isolation & purification*; D002003:Brucella abortus / Q000302:isolation & purification*; D002006:Brucellosis / Q000150:complications / Q000453:epidemiology* / Q000635:transmission; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D003611:Dairy Products / Q000009:adverse effects; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology; D006041:Goats; D006801:Humans; D007223:Infant; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012756:Sheep
D000907:Antibodies, Bacterial