Identification of positive cells to interleukin-4 in bovine haemal nodes.
The bovine haemal nodes are lymphatic organs located in the haemal circulation. Their parenchyma is represented by plasma cells, macrophages and B and T lymphocytes. The T helper type 2 (Th2) CD4 lymphocyte can be found within the T lymphocytes. The activated Th2 CD4 lymphocyte produces interleukin-4 (IL-4), a peptidic hormone involved in the acute-phase immune response. This interleukin can promote either B-lymphocyte differentiation and T-lymphocyte proliferation or it can promote the type of immunoglobulin that can be liberated. Our results have shown, by immunostaining with anti-IL-4, not only the presence and localization of these lymphocytes in bovine haemal nodes but also the participation of polymorphonuclear cells (neutrophils) in the storage of IL-4. These results give value to the humoral and cellular immunological importance of haemal nodes in bovines and they can serve as a contribution to determine the cross-reactivity of bovine IL-4 with the human anti-serum used in this work.
Cerutti
P
P
Department of Anatomy, Faculty of Veterinary Sciences, Campus University, 27001 Lugo, Spain.
Guerrero
F
F
D000818:Animals; D002417:Cattle / Q000033:anatomy & histology / Q000276:immunology*; D007150:Immunohistochemistry / Q000662:veterinary; D015847:Interleukin-4 / Q000032:analysis* / Q000096:biosynthesis; D008198:Lymph Nodes / Q000166:cytology* / Q000276:immunology / Q000648:ultrastructure; D008854:Microscopy, Electron; D018418:Th2 Cells / Q000276:immunology* / Q000648:ultrastructure
D015847:Interleukin-4