[Clinical and neurochemical features of depressive syndrome in neuroses and slowly progressive schizophrenia].
The examination was made of 78 patients (57 women, 21 men) with depression of neurotic level in slow progredient neurosis-like schizophrenia or neurosis. In all the cases of neuroses depressive syndrome correlated with relevant premorbid structure of the person. Meanwhile, such correlation was not clearly observed in schizophrenic patients. Complication of the clinical picture of the depression wasn't the same in cases of schizophrenia and neuroses, and resulted from productive symptomatics of different registers. The results of neurochemical studies evidence, that physiologic inactivation of serotonin, in terms of a removal of the active molecules from a zone of interaction with the receptors, was considerably increased in patients with neuroses as compared with schizophrenic patients. This suggests treatment of neurotic patients with the drugs, which inhibit serotonin reuptake selectively.
Dmitriev
A S
AS
Kogan
B M
BM
Federova
T V
TV
D000328:Adult; D003866:Depressive Disorder / Q000145:classification / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D012559:Schizophrenia / Q000150:complications* / Q000175:diagnosis; D012701:Serotonin / Q000097:blood; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D004298:Dopamine; D004837:Epinephrine; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors
Klinicheskie i neĭrokhimicheskie osobennosti depressivnogo sindroma pri nevrozakh i maloprogredientnoĭ shizofrenii.