title: Cardiovascular comorbidity and mortality in patients starting peritoneal dialysis: an American midwestern center experience.
abstract: End-stage renal disease (ESRD) patients frequently have multiple comorbidities, and cardiovascular disease remains the leading cause of death in these patients. The objectives of the present study were (1) to characterize the number and severity of cardiovascular comorbidities at the start of peritoneal dialysis (PD), and (2) to determine the impact of these comorbidities on mortality. We retrospectively studied all ESRD patients starting peritoneal dialysis at our center between 1990 and 1999. The baseline cardiovascular comorbid factors were categorized as ischemic heart disease, congestive heart failure, arrhythmia, peripheral vascular disease, and cerebrovascular disease. The severity of each factor was scored from 0 to 3. The number of comorbidities and the total cardiovascular comorbidity severity scores were determined for each patient. Cardiovascular deaths included those attributed to sudden death, cardiac disease, cerebrovascular disease, and complications of peripheral vascular disease. Of the 191 patients, 105 were men, and 105 (55%) had diabetes mellitus. The mean age was 60.8 +/- 13.3 years and the mean time on PD was 18.8 +/- 16.3 months. As the number of cardiovascular comorbidities increased, the proportion of patients who died of cardiovascular causes increased eighteen-fold. At each level of cardiovascular comorbidity, diabetic patients starting dialysis were younger, and their survival time was shorter as compared with non diabetic patients. Baseline comorbidity determination is important, as comorbidities are prognostic harbingers of eventual complications.
authors.affiliation: Division of Nephrology, University of Missouri-Columbia, School of Medicine, Columbia, Missouri, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Tan
authors.forename: B F
authors.initials: BF
authors.lastname: Prowant
authors.forename: R
authors.initials: R
authors.lastname: Khanna
authors.forename: K D
authors.initials: KD
authors.lastname: Nolph
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Twardowski
mesh_terms: D002318:Cardiovascular Diseases / Q000145:classification / Q000150:complications* / Q000401:mortality; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D012189:Retrospective Studies; D012720:Severity of Illness Index