Sequence typing confirms that Campylobacter jejuni strains associated with Guillain-Barré and Miller-Fisher syndromes are of diverse genetic lineage, serotype, and flagella type.
Guillain-Barré syndrome (GBS) and Miller-Fisher syndrome (MFS) are correlated with prior infection by Campylobacter jejuni in up to 40% of cases. Nucleotide sequence-based typing of 25 C. jejuni isolates associated with neuropathy permitted robust comparisons with equivalent data from approximately 800 C. jejuni isolates not associated with neuropathy. A total of 13 genetic lineages and 20 flaA short variable region nucleotide sequences were present among the 25 isolates. A minority of isolates (4 of 25) had the flaA short variable region nucleotide sequences that were previously proposed as a marker for GBS-associated isolates. These 4 isolates probably represented the Penner serotype 19 lineage, which has been proposed to have an association with GBS.
Dingle
K E
KE
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3FY, United Kingdom.
Van Den Braak
N
N
Colles
F M
FM
Price
L J
LJ
Woodward
D L
DL
Rodgers
F G
FG
Endtz
H P
HP
Van Belkum
A
A
Maiden
M C
MC
D015373:Bacterial Typing Techniques; D001483:Base Sequence; D002169:Campylobacter Infections / Q000150:complications* / Q000382:microbiology; D016123:Campylobacter jejuni / Q000145:classification* / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D005407:Flagella / Q000145:classification* / Q000235:genetics; D005408:Flagellin / Q000235:genetics; D014644:Genetic Variation; D020275:Guillain-Barre Syndrome / Q000382:microbiology*; D006801:Humans; D019846:Miller Fisher Syndrome / Q000382:microbiology*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012703:Serotyping
D004269:DNA, Bacterial; D005408:Flagellin; C067138:flaA protein, bacteria