title: CD3+CD4-CD8- alphabeta-TCR+ T cell as immune regulatory cell.
abstract: Down-regulation of immune responses by regulatory T cells is one of the major mechanisms involved in the induction of tolerance to self- and alloantigens as demonstrated in a number of models of transplantation and autoimmunity. It is clear that regulatory T cells consist of different subsets. Recently a novel subset of antigen-specific alphabeta-TCR+ CD4-CD8- (double negative, DN) regulatory T cells has been found to be able to inhibit the function of the CD8+ T cells carrying the same T cell receptor specificity and prevent the rejection of skin allografts. Identification of the DN regulatory T cells and their novel mechanism of suppression can help us to understand how donor-specific transplantation tolerance can be achieved and to explain how tolerance to self-antigens can be maintained in the periphery.
authors.affiliation: Multi-Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, 101 College Street, CCRW2-815, Toronto, M5A 1E7, Canada. zzhang@transplantunit.org
authors.forename: Z X
authors.initials: ZX
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Young
authors.forename: L
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000276:immunology / Q000378:metabolism*; D015704:CD4 Antigens / Q000032:analysis*; D016827:CD8 Antigens / Q000032:analysis*; D006801:Humans; D007108:Immune Tolerance; D007519:Isoantigens / Q000276:immunology / Q000378:metabolism; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D014181:Transplantation Immunology
chemical_list: D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D007519:Isoantigens; D016693:Receptors, Antigen, T-Cell, alpha-beta