[Mechanisms of suppression of alcohol motivation after immunization of albino rats against alcohol dehydrogenase I: The role of ADH epitopes and ADH activity in the adrenal glands].
Experimental results have demonstrated a significant decrease in the level of alcohol consumption by albino rats immunized with heterologous horse alcohol dehydrogenase. The role of ADH epitopes 9-14, 93-115, and 265-276 in this phenomenon was examined, and it was established that the latter sequence (265-276) plays the biggest role. The inhibition of ADH activity in the adrenals of immunized rats was much higher compared to the liver. We propose a hypothesis that the effect of alcohol dehydrogenase on alcohol consumption is connected with its role in catecholamine metabolism.
Danilova
R A
RA
Moscow State University, Biology Department, Moscow, 119899 Russia.
Prozorovskiĭ
V N
VN
Moskvitina
T A
TA
Obukhova
M F
MF
Lovat'
M L
ML
Fedorova
I M
IM
Ashmarin
I P
IP
D000311:Adrenal Glands / Q000201:enzymology / Q000276:immunology*; D000426:Alcohol Dehydrogenase / Q000276:immunology*; D000428:Alcohol Drinking / Q000276:immunology* / Q000517:prevention & control; D000818:Animals; D004789:Enzyme Activation / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D007114:Immunization; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000939:Epitopes; D000426:Alcohol Dehydrogenase
O mekhanizmakh podavleniia alkogol'noĭ motivatsii pri immunizatsii belykh krys k alkogol'degidrogenaze I: rol' épitopov ADG i aktivnosti ADG v nadpochechnikakh.