title: Serum anti-p53 autoantibodies in patients with type 1 diabetes.
abstract: The presence of antibodies reacting with the p53 tumor suppressor protein has been described in patients with some autoimmune disorders. In this study we looked for serum anti-p53 antibodies in 64 patients with autoimmune type 1 diabetes mellitus within 4 mo of diagnosis. The presence of anti-p53 antibodies was observed in 6/64 (9.4%) subjects with type 1 diabetes, and in 1/44 (2.3%) subjects with other organ-specific autoimmune diseases (18 primary biliary cirrhosis, 10 autoimmune hepatitis, 16 thyroid diseases), but in none of 45 control subjects. No relationship was found between antibodies directed against islet- and non-islet-specific antigens and anti-p53 antibodies. These findings support a possible role for p53 in some autoimmune disorders.
authors.affiliation: Department of Internal Medicine, University of Messina, Italy. domenico.cucinotta@unime.it
authors.forename: E
authors.initials: E
authors.lastname: Di Cesare
authors.forename: M
authors.initials: M
authors.lastname: Previti
authors.forename: F
authors.initials: F
authors.lastname: Lombardo
authors.forename: A
authors.initials: A
authors.lastname: Di Benedetto
authors.forename: N
authors.initials: N
authors.lastname: Mazzù
authors.forename: G
authors.initials: G
authors.lastname: Romano
authors.forename: F
authors.initials: F
authors.lastname: De Luca
authors.forename: A
authors.initials: A
authors.lastname: Lasco
authors.forename: D
authors.initials: D
authors.lastname: Cucinotta
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007223:Infant; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D016159:Tumor Suppressor Protein p53