Circulating cytokines in patients with cat scratch disease.
Levels of circulating interleukin (IL)-2, IL-6, and IL-10, measured by enzyme-linked immunosorbent assay, were significantly higher in patients with cat scratch disease (CSD) than in healthy control subjects; no induction of IL-12 was observed, and levels of interferon-gamma and IL-4 were generally not detectable. This is the first report showing increased circulating cytokine levels in patients with CSD. The induction of these mediators can partly explain some clinical and pathological features of the disease.
Papadopoulos
N G
NG
Research Laboratories, Second Department of Pediatrics, School of Medicine, University of Athens, Athens, Greece. ngp@clubmember.org
Gourgiotis
D
D
Bossios
A
A
Fretzayas
A
A
Moustaki
M
M
Karpathios
T
T
D000907:Antibodies, Bacterial / Q000097:blood; D018416:Bartonella henselae / Q000276:immunology; D016022:Case-Control Studies; D002372:Cat-Scratch Disease / Q000175:diagnosis / Q000276:immunology*; D002648:Child; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male
D000907:Antibodies, Bacterial; D016207:Cytokines; D007376:Interleukin-2; D015850:Interleukin-6; D016753:Interleukin-10; D018664:Interleukin-12; D015847:Interleukin-4; D007371:Interferon-gamma