Role of active oxygen species and antioxidants in photoaging.
The mechanism for the formation of active oxygen species and their reactions with antioxidants is described. The importance of the free radical chain oxidation and the singlet oxygen-dependent oxidation is suggested by a decrease in skin levels of alpha-tocopherol, ubiquinol-10, and ascorbic acid with a concomitant formation of lipid hydroperoxides during UV irradiation of murine skin, and the formation of squalene hydroperoxides in human skin upon UV exposure, respectively.
Yamamoto
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Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Tokyo, Japan.
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D005609:Free Radicals; D010713:Phosphatidylcholines / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D015595:Skin Aging / Q000502:physiology* / Q000528:radiation effects*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism; D014466:Ultraviolet Rays; D014810:Vitamin E / Q000378:metabolism
D000975:Antioxidants; D002788:Cholesterol Esters; D005609:Free Radicals; D010713:Phosphatidylcholines; D017382:Reactive Oxygen Species; C057590:phosphatidylcholine hydroperoxide; D014451:Ubiquinone; D014810:Vitamin E; C081459:cholesteryl ester hydroperoxide; C026663:ubiquinol-10; D001205:Ascorbic Acid