[Early gene expression in the rat brain following administration of corticoliberin in the neostriatum].
Using in situ hybridisation with oligonucleotide probes, an expression of immediate early genes c-fos, jun B, c-jun, and NGFIA in the rat brain was studied following intrastriatal microinjection of corticotropin-releasing hormone (CRH). The hormone induced expression of c-fos, jun B, and NGFIA mRNAs in the neostriatum as well as in its target brain areas, including nucleus accumbens and different cortical areas. The expression of c-jun mRNAs was unaffected. The findings indicate that neuronal activation of the neostriatum and its target brain areas provides one possible mechanism for mediating adaptive CRH actions in stress.
Rybnikova
E A
EA
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Pelto-Huikko
M
M
Shaliapina
V G
VG
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology* / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D051766:Early Growth Response Protein 1; D015870:Gene Expression; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D008845:Microinjections; D017072:Neostriatum / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D017874:Immediate-Early Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors; D003346:Corticotropin-Releasing Hormone
Ekspressiia rannikh genov v mozgu krys posle vvedeniia kortikoliberina v neostriatum.