Cisplatin: from DNA damage to cancer chemotherapy.
Cisplatin [cis-DDP, cis-diamminedichloroplatinum(II)] is a potent anticancer drug that has been used successfully to treat tumors of the head, neck, lungs, and genitourinary tract. The biological activity of cisplatin was discovered serendipitously more than 30 years ago, and since that time research efforts have focused on elucidating its mechanism of action. The present review provides a historical perspective of our attempts to understand this complex phenomenon and the results of recent work that guides our current activities in this field. Continued efforts to understand the mechanism of genotoxicity of cisplatin are expected to lead to the discovery of new drugs and combinations for the improvement of cancer chemotherapy.
Cohen
S M
SM
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Lippard
S J
SJ
D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002945:Cisplatin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D018736:DNA Adducts / Q000737:chemistry / Q000378:metabolism; D004249:DNA Damage; D006609:High Mobility Group Proteins / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011485:Protein Binding; D017386:Sequence Homology, Amino Acid; D013816:Thermodynamics
D000970:Antineoplastic Agents; D018736:DNA Adducts; D006609:High Mobility Group Proteins; C057270:cisplatin-DNA adduct; D002945:Cisplatin