title: Anterior spinal decompression in HIV-positive patients with tuberculosis.  A prospective study.
abstract: total of 39 HIV-infected adults with spinal tuberculosis underwent anterior spinal decompression for neurological deficit. Fresh-frozen allografts were used in 38 patients. Antituberculous drugs were prescribed for 18 months, but antiretroviral therapy was not used. Six patients died within two years of surgery. Neurological recovery and allograft incorporation were observed at follow-up at a mean of 38 months, although the CD4/CD8 ratios were reversed in all patients. Adequate preoperative nutritional support and compliance with antituberculous treatment are essential in ensuring a satisfactory outcome.
authors.affiliation: Department of Orthopaedic Surgery, University of Natal, South Africa.
authors.forename: S
authors.initials: S
authors.lastname: Govender
authors.forename: A H
authors.initials: AH
authors.lastname: Parbhoo
authors.forename: K P
authors.initials: KP
authors.lastname: Kumar
authors.forename: K
authors.initials: K
authors.lastname: Annamalai
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D016025:Bone Transplantation; D019299:Decompression, Surgical; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016131:Lymphocyte Subsets; D008297:Male; D011446:Prospective Studies; D014184:Transplantation, Homologous; D014399:Tuberculosis, Spinal / Q000150:complications* / Q000601:surgery*
chemical_list: D000995:Antitubercular Agents