Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones.
[reaction: see text]. The solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones from resin-bound amino acids is described. The exhaustive reduction of solid-support bound amides with borane afforded the requisite secondary amines, which following treatment with phenyl isocyanatoformate and cleavage, provided the corresponding triazepane-2,4-diones.
Yu
Y
Y
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA.
Ostresh
J M
JM
Houghten
R A
RA
D000596:Amino Acids / Q000737:chemistry*; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D001880:Boranes / Q000737:chemistry; D010084:Oxidation-Reduction
D000596:Amino Acids; D001381:Azepines; D001880:Boranes