[Circumscribed hypertrichosis lanuginosa in acute myeloid leukemia].
METHODS
The case of a 70 year old male is presented. Past medical history revealed the following diagnoses: liver cirrhosis, splenomegaly, thrombocytopenia, macrocytic anaemia, chronic obstructive pulmonary disease, type IIa diabetes mellitus and peripheral vascular disease of the lower limbs with chronic leg ulcers. Within 6 weeks the patient developed an increasing number of pigmented lanugo type hair over both cheeks, zygomatic arches and temples. The diagnosis of circumscribed acquired hypertrichosis lanuginosa (AHL) was established. Bone marrow biopsy revealed presence of acute myeloid leukemia.


METHODS
Chemotherapy with hydroxycarbamide (Syrea) was started without effect on haematologic parameters. The patient was transferred to the oncology unit where he died soon afterwards.


CONCLUSIONS
Acquired hypertrichosis lanuginosa (AHL) is a paraneoplastic syndrome. It is mainly associated with adenocarcinoma of lung and bowel, however other histologic types of tumours and localisations have been described. About 50 cases have been reported in the literature until 1998. To our knowledge this is the first case of AHL described in association with acute myeloid leukemia.
Bauer
H I
HI
Klinik für Dermatologie und dermatologische Allergologie der Friedrich-Schiller-Universität Jena. heike.bauer@med.derma.uni-jena.de
Kaatz
M
M
Elsner
P
P
D000208:Acute Disease; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D006983:Hypertrichosis / Q000209:etiology*; D007951:Leukemia, Myeloid / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology*
D000970:Antineoplastic Agents; D006918:Hydroxyurea
Umschriebene Hypertrichosis lanuginosa bei akuter myeloischer Leukämie.