Applying hormesis in aging research and therapy.
Biology of aging is well understood at a descriptive level. Based on these data, biogerontological research is now able to develop various possibilities for intervention. A promising approach for the identification of gerontogenes and gerontogenic processes is through the hormetic effects of mild stress on slowing down aging. Although there are several issues remaining to be resolved, specially with regard to the notion of mild stress, application of hormesis in aging research and therapy is a powerful new approach.
Rattan
S I
SI
Danish Centre for Molecular Gerontology, Department of Molecular and Structural Biology, University of Aarhus, Denmark.
D000375:Aging / Q000502:physiology*; D002468:Cell Physiological Phenomena; D004249:DNA Damage; D004260:DNA Repair; D002149:Energy Intake; D004781:Environmental Exposure; D015444:Exercise; D005786:Gene Expression Regulation; D005853:Geriatrics / Q000639:trends*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008017:Life Expectancy; D019216:Metals, Heavy / Q000009:adverse effects; D016877:Oxidants / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects; D015854:Up-Regulation; D015262:Xenobiotics / Q000009:adverse effects
D019216:Metals, Heavy; D016877:Oxidants; D015262:Xenobiotics