title: Enhanced lipid peroxidation processes in patients after brain contusion.
abstract: Erythrocyte superoxide dismutase (SOD-1) activity and cerebrospinal fluid (CSF), blood plasma low-density lipoprotein (LDL) and erythrocyte thiobarbituric acid reactive substance (TBARS) concentrations were determined in 30 patients with brain contusion and in 37 control patients with low back pain due to noninflammatory degenerative lumbar disc disease. In comparison to controls, during 10-day follow-up patients with brain contusion had significantly increased erythrocyte SOD-1 activity and CSF, blood plasma (LDL), and erythrocyte TBARS concentrations. The highest CSF TBARS concentrations were observed in five patients who died 2, 7, or 8 days following head injury. A significant negative correlation was found between erythrocyte SOD-1 activity or TBARS concentrations, in the blood plasma LDL fraction and erythrocytes, and The Glasgow Coma Scale score. These results suggest that enhanced lipid peroxidation processes, which seem to correlate with the severity of head injury, accompany brain contusion.
authors.affiliation: Department of Neurosurgery, Ludwik Rydygier Medical University, Bydgoszcz, Poland. bartoszw@poczta.wp.pl
authors.forename: H A
authors.initials: HA
authors.lastname: Kasprzak
authors.forename: A
authors.initials: A
authors.lastname: Woźniak
authors.forename: G
authors.initials: G
authors.lastname: Drewa
authors.forename: B
authors.initials: B
authors.lastname: Woźniak
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000378:metabolism*; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000032:analysis / Q000134:cerebrospinal fluid; D000072105:Superoxide Dismutase-1; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D008078:Cholesterol, LDL; C000606290:SOD1 protein, human; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1