title: [Induction of co-stimulatory molecules on the surface of blast cells in patients with acute myeloid leukemia].
abstract: OBJECTIVE
  To compare the capacity of ionophore for calcium ions and growth factors (granulocytic-macrophagal colony-stimulating factor, interleukin-4, tumor necrosis factor) to induce costimulatory molecules on the surface of blast cells from patients with acute myeloid leukemia (AML).
  
  
  METHODS
  The study was carried out in 6 patients with primary and resistant AML using culturing and flow cytometry.
  
  
  RESULTS
  Blast cells obtained from patients during diagnosis of AML and after drug therapy of resistant AML acquire the dendrite phenotype under the effects of growth factors and Ca ion ionophore.
  
  
  CONCLUSIONS
  Calcium metabolism modulators can be used for creation of antileukemic vaccines.
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Sadovnikova
authors.forename: T B
authors.initials: TB
authors.lastname: Strel'nikova
authors.forename: E N
authors.initials: EN
authors.lastname: Parovichnikova
authors.forename: V G
authors.initials: VG
authors.lastname: Savchenko
mesh_terms: D000208:Acute Disease; D000328:Adult; D000938:Antigen-Presenting Cells; D002118:Calcium / Q000494:pharmacology; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D016130:Immunophenotyping; D007167:Immunotherapy; D007476:Ionophores; D007477:Ions; D007951:Leukemia, Myeloid / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D006133:Growth Substances; D007476:Ionophores; D007477:Ions; D002118:Calcium
vernacular_title: Induktsiia kostimuliatornykh molekul na poverkhnosti blastnykh kletok u bol'nykh ostrymi mieloidnymi leĭkozami.