title: AIIMS clinical score: a reliable aid to distinguish neonatal hepatitis from extra hepatic biliary atresia.
abstract: It is important to distinguish neonatal hepatitis (NH) from extra hepatic biliary atresia (EHBA) in a neonate presented with jaundice as the former is purely medical management and the latter requires surgical procedure at the earliest. The observations on the critical evaluation of the neonatal jaundice cases led us to propose AIIMS clinical score (ACS) and this retrospective study was designed to evaluate the reliability of the ACS in all the 120 babies with jaundice referred to the pediatric surgery department during the past 10 year period. The ACS described here is based on 5 clinical parameters--Age, Jaundice, Colour of urine and stool and Clinical examination of liver. The accuracy of the hepatobiliary scan (HBS) with respect to the diagnosis of EHBA in this series, as compared to per operative cholangiography (POC) which is considered as the gold standard to distinguish these conditions was only 68%. However, ACS showed a sensitivity of 91.5%, a specificity of 76.3%, positive predictive value of 89.2%, negative predictive value of 80.5% and an overall diagnostic accuracy of 86.6%. ACS is reliable to distinguish NH from EHBA at bedside.
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi-110029, India. devendra6@hotmail.com
authors.forename: D K
authors.initials: DK
authors.lastname: Gupta
authors.forename: M
authors.initials: M
authors.lastname: Srinivas
authors.forename: M
authors.initials: M
authors.lastname: Bajpai
mesh_terms: D001656:Biliary Atresia / Q000175:diagnosis*; D019411:Clinical Laboratory Techniques; D003937:Diagnosis, Differential; D005243:Feces / Q000737:chemistry; D005260:Female; D006505:Hepatitis / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000175:diagnosis*; D008099:Liver / Q000473:pathology*; D008297:Male; D010808:Physical Examination; D015203:Reproducibility of Results; D012107:Research Design; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D016482:Urinalysis