title: Characteristics of anticoagulant therapy and comorbidity related to overanticoagulation.
abstract: The risk of hemorrhage when using coumarin anticoagulants sharply increases when the International Normalised Ratio (INR) is > or =6.0. We performed a prospective cohort study with a nested case-control design among 17,056 outpatients of an anticoagulation clinic to determine the incidence of overanticoagulation and to study the association between overanticoagulation and characteristics of anticoagulant therapy and comorbidity. The incidence rate of an INR > or =6.0 was 7.8 per 10,000 treatment days in prevalent users on the starting date and 22.5 per 10,000 treatment days in incident users during the study period. 300 cases with an INR > or =6.0 were compared with 302 randomly selected matched controls with an INR within the target zone. Patients on acenocoumarol had an increased risk of an INR > or =6.0 compared to patients on phenprocoumon. Regarding comorbidity, impaired liver function, congestive heart failure, diarrhea and fever were risk factors for overanticoagulation. Increased monitoring of INR values if risk factors are present or avoidance of risk factors could prevent excess anticoagulation and potential bleeding complications.
authors.affiliation: Pharmaco-epidemiology Unit, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: F J
authors.initials: FJ
authors.lastname: Penning-van Beest
authors.forename: E
authors.initials: E
authors.lastname: van Meegen
authors.forename: F R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects / Q000592:standards* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D016022:Case-Control Studies; D015331:Cohort Studies; D015897:Comorbidity; D003374:Coumarins / Q000009:adverse effects / Q000627:therapeutic use; D016903:Drug Monitoring; D062787:Drug Overdose / Q000150:complications / Q000209:etiology; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000925:Anticoagulants; D003374:Coumarins