title: A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis.
abstract: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4(+) and CD8(+) T cells. Studies of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, focus on the contribution of CD4(+) myelin-specific T cells. The role of CD8(+) myelin-specific T cells in mediating EAE or MS has not been described previously. Here, we demonstrate that myelin-specific CD8(+) T cells induce severe CNS autoimmunity in mice. The pathology and clinical symptoms in CD8(+) T cell-mediated CNS autoimmunity demonstrate similarities to MS not seen in myelin-specific CD4(+) T cell-mediated EAE. These data suggest that myelin-specific CD8(+) T cells could function as effector cells in the pathogenesis of MS.
authors.affiliation: Department of Immunology, University of Washington, Seattle, Washington 98195, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Huseby
authors.forename: D
authors.initials: D
authors.lastname: Liggitt
authors.forename: T
authors.initials: T
authors.lastname: Brabb
authors.forename: B
authors.initials: B
authors.lastname: Schnabel
authors.forename: C
authors.initials: C
authors.lastname: Ohlén
authors.forename: J
authors.initials: J
authors.lastname: Goverman
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D015551:Autoimmunity; D001921:Brain / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002999:Clone Cells; D004195:Disease Models, Animal; D051379:Mice; D008809:Mice, Inbred C3H; D019463:Mice, Inbred MRL lpr; D016513:Mice, SCID; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D004676:Myelin Basic Protein / Q000276:immunology*; D013116:Spinal Cord / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
chemical_list: D004676:Myelin Basic Protein