Self-cytoprotection against stress: feedback regulation of heme-dependent metabolism.
This minireview provides insight into feedback regulation of heme-dependent metabolism as a defensive cellular response against stress. Interactions among heme-, iron-, porphyrin-, and CO/NO-dependent metabolic pathways during the stress-induced response are emphasized in the context of feedback regulation. The hypothetical model of the latter interactions is presented as tightly controlled feedback cycles.
Schwartsburd
P M
PM
Institute of Theoretical and Experimental Biophysics, Russian Academy of Science, Moscow Region, Puschino. schwartsburd@venus.iteb.serpukhov.su
D000818:Animals; D005246:Feedback / Q000502:physiology; D006418:Heme / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*
D006418:Heme; D006419:Heme Oxygenase (Decyclizing)