title: Radiological features predictive of aseptic loosening in cemented Charnley femoral stems.
abstract: The radiological features of the cement mantle around total hip replacements (THRs) have been used to assess aseptic loosening. In this case-control study we investigated the risk of failure of THR as predictable by a range of such features using data from patients recruited to the Trent Regional Arthroplasty Study (TRAS). An independent radiological assessment was undertaken on Charnley THRs with aseptic loosening within five years of surgery and on a control group from the TRAS database. Chi-squared tests were used to test the probability of obtaining the observed data by chance, and odds ratios were calculated to estimate the strength of association for different features. Several features were associated with a clinically important increase (>twofold) in the risk of loosening, which was statistically significant for four features (p < 0.01). Inadequate cementation (Barrack C and D grades) was the most significant feature, with an estimated odds ratio of 9.5 (95% confidence interval 3.2 to 28.4, p < 0.0001) for failure.
authors.affiliation: Department of Orthopaedic Surgery, Freeman Hospital, Newcastle upon Tyne, England, UK.
authors.forename: I R
authors.initials: IR
authors.lastname: Chambers
authors.forename: D
authors.initials: D
authors.lastname: Fender
authors.forename: A W
authors.initials: AW
authors.lastname: McCaskie
authors.forename: B C
authors.initials: BC
authors.lastname: Reeves
authors.forename: P J
authors.initials: PJ
authors.lastname: Gregg
mesh_terms: D016022:Case-Control Studies; D002484:Cementation; D006622:Hip Prosthesis; D006801:Humans; D011237:Predictive Value of Tests; D011475:Prosthesis Failure