Central mu opioid receptor mechanisms modulate mustard oil-evoked jaw muscle activity.
The injection of the small-fibre excitant and inflammatory irritant mustard oil (MO) into the temporomandibular joint (TMJ) region of rats evokes a sustained and reversible increase in electromyographic (EMG) activity of jaw muscles. The 'rekindling' of this nociceptive reflex by intrathecal (i.t.) administration of the opiate antagonist naloxone and mu but not delta and kappa selective opioid antagonist, suggests that it may be modulated by endogenous opioid inhibitory mechanisms.
Tambeli
C H
CH
Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6.
Seo
K
K
Sessle
B J
BJ
Hu
J W
JW
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008410:Masticatory Muscles / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009149:Mustard Plant; D009292:Narcotic Antagonists / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009619:Nociceptors / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010146:Pain / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D010936:Plant Extracts / Q000494:pharmacology; D010938:Plant Oils; D051381:Rats; D017207:Rats, Sprague-Dawley; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D013704:Temporomandibular Joint / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D014275:Trigeminal Caudal Nucleus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D009292:Narcotic Antagonists; D010936:Plant Extracts; D010938:Plant Oils; D017450:Receptors, Opioid, mu; C027793:mustard oil