title: Apoptotic UV-irradiated lymphocytes undergo protease mediated shedding of L-selectin in vitro.
abstract: Adhesion between circulating lymphocytes and endothelial cells of the vessel wall depends on the expression of selectins and is the first step of tissue invasion which characterises inflammation. UV-B is well known to induce apoptosis in lymphocytes. We show that induction of apoptosis by any procedure leads to a metalloprotease mediated shedding of L-selectin from the surface of T-lymphocytes. Together with the previously published immunosuppressive action of apoptotic cells, this may contribute to the clinical effect of UV-B application, especially in photopheresis.
authors.affiliation: Department of Internal Medicine/Rheumatology, Franz von Pruemmer Klinik, Bad Brueckenau, Germany.
authors.forename: P M
authors.initials: PM
authors.lastname: Kern
authors.forename: L
authors.initials: L
authors.lastname: Keilholz
authors.forename: J R
authors.initials: JR
authors.lastname: Kalden
authors.forename: M
authors.initials: M
authors.lastname: Herrmann
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D019041:L-Selectin / Q000187:drug effects / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects*; D008666:Metalloendopeptidases / Q000378:metabolism / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D019041:L-Selectin; D008666:Metalloendopeptidases