title: Cholestane glycosides from the bulbs of Galtonia candicans and their cytotoxicity.
abstract: Further search for cytotoxic compounds contained in the bulbs of Galtonia candicans (Liliaceae) led to the isolation of four potent cytotoxic cholestane glycosides (1-4) based upon 3beta,16beta,17alpha-trihydroxycholest-5-en-22-one, three of which (2-4) have not been reported previously. A new cholestane bisdesmoside (5) and a new rearranged cholestane glycoside (6) were also isolated. The structural assignment of the new constituents was carried out by spectroscopic analysis and a few chemical transformations.
authors.affiliation: Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kuroda
authors.forename: Y
authors.initials: Y
authors.lastname: Mimaki
authors.forename: A
authors.initials: A
authors.lastname: Yokosuka
authors.forename: Y
authors.initials: Y
authors.lastname: Sashida
mesh_terms: D002776:Cholestanes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D019668:Liliaceae / Q000737:chemistry / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018514:Plant Structures / Q000737:chemistry / Q000633:toxicity
chemical_list: D002776:Cholestanes; D003603:Cytotoxins; D006027:Glycosides; D010936:Plant Extracts