Anti-inflammatory effects of 17beta-estradiol pretreatment in men after coronary artery surgery.
OBJECTIVE
To investigate the anti-inflammatory and hemodynamic effects of 17beta-estradiol in men undergoing elective coronary artery bypass graft surgery (CABG).


METHODS
Prospective, randomized, controlled.


METHODS
Operating room and intensive care unit in a university hospital.


METHODS
Twenty-one men undergoing primary, elective CABG surgery.


METHODS
17beta-estradiol, 2mg, was given orally twice in 14 hours before the operation.


RESULTS
Leukocyte counts, plasma myeloperoxidase, tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and IL-10 were measured perioperatively. Leukocyte counts were lower in the 17beta-estradiol group than in controls at 6 hours (11.4 +/- 2.0 hours v 15.5 +/- 4.7 hours x 10(9)/L) and 20 hours (11.6 +/- 1.9 hours v 13.6 +/- 2.5 hours x 10(9)/L) after reperfusion (p = 0.03). The release of myeloperoxidase was lower in the 17beta-estradiol group than in controls (5 minutes; 634.4 +/- 213.1 microg/mL v 773.1 +/- 209.3 microg/mL; 4 hours, 305.0 +/- 108.0 microg/mL v 441.3 +/- 191.6 microg/mL; p = 0.02). Systemic vascular resistance index was lower just after cardiopulmonary bypass, and cardiac index was higher postoperatively in the 17beta-estradiol group as compared with controls.


CONCLUSIONS
Pretreatment with 17beta-estradiol can limit leukocyte activation in men after CABG surgery.
Wei
M
M
Division of Cardiovascular Surgery, Department of Anesthesia and Intensive Care, Tampere University Hospital, Tampere, Finland.
Kuukasjärvi
P
P
Kaukinen
S
S
Laurikka
J
J
Pehkonen
E
E
Laine
S
S
Moilanen
E
E
Metsänoja
R
R
Tarkka
M
M
D000284:Administration, Oral; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D016207:Cytokines / Q000097:blood*; D004958:Estradiol / Q000008:administration & dosage* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood; D011292:Premedication; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D004958:Estradiol; D009195:Peroxidase