Relationship between pancreatitis and lung diseases.
Patients with acute pancreatitis may develop acute lung injury, manifest clinically as the adult respiratory distress syndrome. Most patients who die during the early stages of severe acute pancreatitis die either with or as a result of this lung injury. To explore the events which couple acute pancreatitis to lung injury, a number of recent studies have been performed in the author's laboratory using a variety of experimental models and interventions including gene-targeted deletion of chemokines, cytokines, specific receptors, and adhesion molecules. These studies have indicated that adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), neutrophils, platelet activating factor (PAF), substance P, and chemokines acting via the CCR-1 chemokine receptor play a pro-inflammatory role while complement factor C5a plays an anti-inflammatory role in pancreatitis and lung injury. Future studies will build on these observations to expand the list of pro- and anti-inflammatory coupling factors and explore the mechanisms by which they act to cause or prevent lung injury in acute pancreatitis.
Steer
M L
ML
Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. msteer@caregroup.harvard.edu
D000208:Acute Disease; D000818:Animals; D015936:Complement C5a / Q000235:genetics / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000502:physiology; D008171:Lung Diseases / Q000209:etiology*; D051379:Mice; D018345:Mice, Knockout; D009504:Neutrophils / Q000502:physiology; D010195:Pancreatitis / Q000150:complications*; D010972:Platelet Activating Factor / Q000502:physiology; D051381:Rats; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000235:genetics / Q000502:physiology; D013373:Substance P / Q000502:physiology
C515300:CCR1 protein, human; C515301:Ccr1 protein, mouse; C515302:Ccr1 protein, rat; D010972:Platelet Activating Factor; D054389:Receptors, CCR1; D019707:Receptors, Chemokine; D018799:Intercellular Adhesion Molecule-1; D013373:Substance P; D015936:Complement C5a