Angiotensin converting enzyme inhibitor induced cough in Nigerians.
A persistent dry cough is the commonest class of adverse reaction to Angiotensin converting enzyme inhibitors (ACE-I). This ACE-I induced cough appears to exhibit interracial differences being commoner in Chinese subjects as compared to Caucasians. We conducted a cross sectional study of one hundred (100) patients (63 males and 37 females) on ACE-I to determine the prevalence of ACE-induced cough in Nigerians, a Negroid population. Twenty seven patients (27%) had ACE-induced cough and four (4%) had withdrawal of ACE-I therapy on account of cough. The prevalence of ACE-I induced cough was significantly higher amongst females (43%) as compared to males (17%) p < 0.01. The biological basis for the apparent racial and gender differences in ACE-I induced cough requires further study.
Adigun
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AQ
Department of Medicine, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Osun State.
Ajayi
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AA
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D044383:Black People / Q000235:genetics; D003371:Cough / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D011159:Population Surveillance; D015995:Prevalence; D012720:Severity of Illness Index; D017678:Sex Distribution; D011795:Surveys and Questionnaires
D000806:Angiotensin-Converting Enzyme Inhibitors