Neuronal nicotinic receptors: from protein structure to function.
Neuronal nicotinic acetylcholine receptors are a prototype of ligand-gated channels that mediate transmission in the central and peripheral nervous system. Structure-function studies performed at the amino acid level are now unraveling the determinant residues either for the properties of the ligand-binding domain or the ionic pore. In this work we review, in the light of the latest finding, the structure-function relationship of these receptors and their implication in neurological diseases.
Itier
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Department of Physiology, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland.
Bertrand
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D000495:Allosteric Site; D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D004594:Electrophysiology; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D009422:Nervous System Diseases / Q000378:metabolism; D009474:Neurons / Q000737:chemistry* / Q000502:physiology*; D017933:Peripheral Nervous System / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000502:physiology*; D013329:Structure-Activity Relationship
D006023:Glycoproteins; D008024:Ligands; D011978:Receptors, Nicotinic