title: Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic.
abstract: We initiated a prospective surveillance study to investigate possible Pseudomonas aeruginosa cross-infection in our cystic fibrosis centre. We characterised isolates by pyocin typing and pulsed-field gel electrophoresis. 22 (14%) of 154 patients with chronic P aeruginosa had isolates with similar and new pyocin and pulsed-field gel electrophoresis types. The shared isolates showed unusual phenotypic features: they were non-pigmented, non-motile, and resistant to a number of antipseudomonal antibiotics. Cross-infection by a multiresistant P aeruginosa strain has therefore occurred in patients attending our cystic fibrosis centre. We recommend microbiological surveillance in other cystic fibrosis centres.
authors.forename: A M
authors.initials: AM
authors.lastname: Jones
authors.forename: J R
authors.initials: JR
authors.lastname: Govan
authors.forename: C J
authors.initials: CJ
authors.lastname: Doherty
authors.forename: M E
authors.initials: ME
authors.lastname: Dodd
authors.forename: B J
authors.initials: BJ
authors.lastname: Isalska
authors.forename: T N
authors.initials: TN
authors.lastname: Stanbridge
authors.forename: A K
authors.initials: AK
authors.lastname: Webb
mesh_terms: D000328:Adult; D003428:Cross Infection / Q000382:microbiology* / Q000635:transmission*; D003550:Cystic Fibrosis / Q000382:microbiology*; D016172:DNA Fingerprinting; D004352:Drug Resistance, Microbial; D016521:Electrophoresis, Gel, Pulsed-Field; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype; D011159:Population Surveillance; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000635:transmission*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification* / Q000472:pathogenicity