Apoptotic UV-irradiated lymphocytes undergo protease mediated shedding of L-selectin in vitro.
Adhesion between circulating lymphocytes and endothelial cells of the vessel wall depends on the expression of selectins and is the first step of tissue invasion which characterises inflammation. UV-B is well known to induce apoptosis in lymphocytes. We show that induction of apoptosis by any procedure leads to a metalloprotease mediated shedding of L-selectin from the surface of T-lymphocytes. Together with the previously published immunosuppressive action of apoptotic cells, this may contribute to the clinical effect of UV-B application, especially in photopheresis.
Kern
P M
PM
Department of Internal Medicine/Rheumatology, Franz von Pruemmer Klinik, Bad Brueckenau, Germany.
Keilholz
L
L
Kalden
J R
JR
Herrmann
M
M
D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D019041:L-Selectin / Q000187:drug effects / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects*; D008666:Metalloendopeptidases / Q000378:metabolism / Q000494:pharmacology*; D014466:Ultraviolet Rays
D019041:L-Selectin; D008666:Metalloendopeptidases