title: Analysis of the mammalian talin2 gene TLN2.
abstract: We have utilised genomic and EST databases to assemble the sequence of the human talin2 (TLN2) gene. Talin2 protein is similar in size and sequence to talin1 throughout its length (74% identity, 86% similarity). The major differences are in (i) the size of the genes, the TLN2 gene is >200 kb compared with approximately 30 kb for TLN1 due to a difference in intron size, although intron/exon boundaries, with the exception of two, are strictly conserved; (ii) the expression patterns, TLN1 gives rise to an approximately 8-kb mRNA which is observed in all tissues, whereas TLN2 gives rise to multiple transcripts with the highest levels in heart.
authors.affiliation: Department of Biochemistry, University of Leicester, University Road, Leicester, LE1 7RH, United Kingdom.
authors.forename: S J
authors.initials: SJ
authors.lastname: Monkley
authors.forename: C A
authors.initials: CA
authors.lastname: Pritchard
authors.forename: D R
authors.initials: DR
authors.lastname: Critchley
mesh_terms: D020413:3' Untranslated Regions; D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D002899:Chromosomes, Human, Pair 9; D017124:Conserved Sequence; D003598:Cytoskeletal Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics*; D005091:Exons; D020224:Expressed Sequence Tags; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000378:metabolism; D016608:Talin / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics*; D014018:Tissue Distribution
chemical_list: D020413:3' Untranslated Regions; D003598:Cytoskeletal Proteins; D012333:RNA, Messenger; C436513:TLN2 protein, human; D016608:Talin