[Plasminogen activators of urokinase and tissue types and their inhibitor (PAI-1) in cytosol fraction in thyroid diseases].
Enzyme immunoassay (ELISA) was used to estimate the levels of plasminogen activators of urokinase (uPA) and tissue (tPA) types and one of their inhibitors (PAI-I) in the cytosolic fraction of the thyroid in 129 patients with malignant and benign tumors and various non-cancer diseases of the gland. Tumors from patients with thyroid cancer displayed the lowest levels of tPA and the highest levels of uPA and PAI-I, while those from patients with benign thyroid diseases, including adenoma, had high concentrations of tPA and relatively low levels of uPA and PAI-I in the tissue of the diseased organ. At the same time, the lowest levels of uPA and PAI-I were found in patients suffering from toxic goiter with and without adenomatosis. In terms of uPA and PAI-I levels, patients with nodular colloidal goiter were intermediate between those with toxic goiter and adenoma, on the one hand, and those with thyroid cancer, on the other.
Kushlinskiĭ
N E
NE
Gershteĭn
E S
ES
Kazantseva
I A
IA
Kharitidi
T Iu
TIu
Liakina
L T
LT
Kazakov
S P
SP
Bagatyrev
O P
OP
Kalinin
A P
AP
D000236:Adenoma / Q000201:enzymology / Q000378:metabolism; D000328:Adult; D003600:Cytosol / Q000737:chemistry / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006044:Goiter, Nodular / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis* / Q000378:metabolism; D015842:Serine Proteinase Inhibitors / Q000032:analysis* / Q000378:metabolism; D013959:Thyroid Diseases / Q000201:enzymology / Q000378:metabolism*; D013961:Thyroid Gland / Q000737:chemistry* / Q000201:enzymology; D013964:Thyroid Neoplasms / Q000201:enzymology / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000032:analysis* / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis* / Q000378:metabolism
D017395:Plasminogen Activator Inhibitor 1; D015842:Serine Proteinase Inhibitors; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator
Aktivatory plazminogena urokinaznogo i tkanevogo tipov i ikh ingibitor (PAI-I) v tsitozol'noĭ fraktsii pri zabolevaniiakh shchitovidnoĭ zhelezy.