Bioorganic applications of semisynthetic DNA-protein conjugates.
Semisynthetic DNA-protein conjugates are versatile molecular tools useful, for instance, in the self-assembly of high-affinity reagents for immunological detection assays, the fabrication of highly functionalized laterally microstructured biochips, and the biomimetic "bottom-up" synthesis of nanostructured supramolecular devices. This concept paper summarizes the current state-of-the-art concerning the synthesis, characterization, and applications of such hybrid molecules, and also draws perspectives on future developments.
Niemeyer
C M
CM
Universität Bremen, Biotechnologie und Molekulare Genetik, Germany. cmn@biotec.uni-bremen.de
D001665:Binding Sites / Q000502:physiology; D004247:DNA / Q000737:chemistry*; D007118:Immunoassay / Q000379:methods; D008832:Microchemistry; D020411:Oligonucleotide Array Sequence Analysis; D009841:Oligonucleotides / Q000737:chemistry*; D011506:Proteins / Q000138:chemical synthesis* / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry*
D009841:Oligonucleotides; D011506:Proteins; D004247:DNA; D019809:Streptavidin