title: Attempts to measure sensitiser photophysics in opaque tissue.
abstract: Diffuse reflectance laser flash photolysis has been used in an attempt to measure transient triplet spectra of the sensitisers, disulphonated aluminium phthalocyanine and porphyrin IX (derived from 5-amino laevulinic acid), in opaque tissue and models. The latter consisted of tissue phantoms; the former included rat liver and red blood cells. In all cases, triplet-triplet absorption spectra with relatively poor signal-to-noise were obtained providing some encouragement in the application of this technique to in vivo studies on photosensitisers.
authors.affiliation: Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AY, UK.
authors.forename: T C
authors.initials: TC
authors.lastname: Oldham
authors.forename: D
authors.initials: D
authors.lastname: Phillips
authors.forename: A J
authors.initials: AJ
authors.lastname: MacRobert
mesh_terms: D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D007211:Indoles / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D010782:Photolysis; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C064331:aluminum phthalocyanine disulfonate; D000622:Aminolevulinic Acid