title: Effects of covariance model assumptions on hypothesis tests for repeated measurements: analysis of ovarian hormone data and pituitary-pteryomaxillary distance data.
abstract: In the analysis of repeated measurements, multivariate methods which account for the correlations among the observations from the same experimental unit are widely used. Two commonly-used multivariate methods are the unstructured multivariate approach and the mixed model approach. The unstructured multivariate approach uses MANOVA types of models and does not require assumptions on the covariance structure. The mixed model approach uses multivariate linear models with random effects and requires covariance structure assumptions. In this paper, we describe the characteristics of tests based on these two methods of analysis and investigate the performance of these tests. We focus particularly on tests for group effects and parallelism of response profiles.
authors.affiliation: Department of Statistics, Seoul National University, San 56-1 Shin Lim-Dong, Kwanak-Gu, Seoul, Korea 151-742.
authors.forename: T
authors.initials: T
authors.lastname: Park
authors.forename: J K
authors.initials: JK
authors.lastname: Park
authors.forename: C S
authors.initials: CS
authors.lastname: Davis
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001835:Body Weight; D002648:Child; D003625:Data Collection / Q000379:methods*; D003627:Data Interpretation, Statistical; D015987:Effect Modifier, Epidemiologic; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D016014:Linear Models; D008297:Male; D008437:Maxilla / Q000033:anatomy & histology / Q000254:growth & development; D015233:Models, Statistical; D009010:Monte Carlo Method; D015999:Multivariate Analysis; D024510:Muscle Development; D010053:Ovary / Q000502:physiology; D010902:Pituitary Gland / Q000033:anatomy & histology / Q000254:growth & development; D011276:Pregnanediol / Q000652:urine; D011626:Pterygoid Muscles / Q000033:anatomy & histology / Q000254:growth & development; D011897:Random Allocation
chemical_list: D012739:Gonadal Steroid Hormones; D011276:Pregnanediol