title: Pituitary apoplexy caused by luteinizing hormone-releasing hormone in prolactin-producing adenoma.
abstract: We report a case in which pituitary apoplexy developed shortly after an intravenous (i.v.) injection of luteinizing hormone-releasing hormone (LH-RH). A 56-year-old man with prolactin-producing pituitary tumor complained of severe headache, visual field loss and facial nerve palsy shortly after LH-RH test. Magnetic resonance image (MRI) revealed a hemorrhage in the pituitary adenoma. He showed dramatic improvement in his symptoms after decompression surgery. These findings suggest a causal relationship between the i.v. injection of LH-RH and pituitary apoplexy. Possible pituitary apoplexy should be kept in mind during pituitary testing.
authors.affiliation: First Department of Internal Medicine, Toho University School of Medicine, Tokyo.
authors.forename: N
authors.initials: N
authors.lastname: Hiroi
authors.forename: T
authors.initials: T
authors.lastname: Ichijo
authors.forename: M
authors.initials: M
authors.lastname: Shimojo
authors.forename: H
authors.initials: H
authors.lastname: Ueshiba
authors.forename: K
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
mesh_terms: D005158:Facial Paralysis / Q000209:etiology; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000009:adverse effects*; D006065:Gonadotropins, Pituitary; D006261:Headache / Q000209:etiology; D006728:Hormones / Q000097:blood; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010899:Pituitary Apoplexy / Q000097:blood / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000175:diagnosis*; D015175:Prolactinoma / Q000175:diagnosis*; D014786:Vision Disorders / Q000209:etiology
chemical_list: D006065:Gonadotropins, Pituitary; D006728:Hormones; D007987:Gonadotropin-Releasing Hormone