Arterial and mixed venous xenon blood concentrations in pigs during wash-in of inhalational anaesthesia.
There are no data available on the kinetics of blood concentrations of xenon during the wash-in phase of an inhalation anaesthesia aiming at 1 MAC end-expiratory concentration. Therefore, we anaesthetized eight pigs with continuous propofol and fentanyl and measured arterial, mixed venous and end-expiratory xenon concentrations by gas chromatography-mass spectrometry 1, 2, 3, 4, 5, 7, 10, 15, 20, 30, 60 and 120 min after starting the anaesthetic gas mixture [67% xenon/33% oxygen; 3 litre x min(-1) during the first 10 min, thereafter minimal flow with 0.48 (SD 0.03) litre x min(-1)]. End-expiratory xenon concentrations plateaued (defined as <5% change from the preceding value) at 64 (6) vol% after 7 min, and arterial and mixed venous xenon concentrations after 5 and 15 min respectively. The highest arterio-venous concentration difference occurred after 3 min. Using the Fick principle, we calculated a mean xenon uptake of 3708 (829) and 9977 (3607) ml after 30 and 120 min respectively.
Nalos
M
M
Universitätsklinik für Anästhesiologie, Universität Ulm, Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Parkstrasse 11, D-89073 Ulm, Germany.
Wachter
U
U
Pittner
A
A
Georgieff
M
M
Radermacher
P
P
Froeba
G
G
D000769:Anesthesia, Inhalation / Q000379:methods; D018685:Anesthetics, Inhalation / Q000097:blood* / Q000493:pharmacokinetics; D000818:Animals; D013552:Swine; D014978:Xenon / Q000097:blood* / Q000493:pharmacokinetics
D018685:Anesthetics, Inhalation; D014978:Xenon