title: Exposure to persistent organochlorines among Alaska Native women.
abstract: OBJECTIVE
  To report the levels of DDT, DDE, other chlorinated pesticides, and PCBs found in 131 Alaska Native women who had serum samples collected between 1980 and 1987 and to compare these levels to other published studies of DDE and PCB exposure among U.S. women.
  
  
  METHODS
  Review of data collected during a case-control study of the relationship between organochlorine chemicals and breast cancer. Data for case and control women were pooled in this analysis because case-control differences were found to be minimal and because serum samples pre-dated cancer diagnoses by 3 to 10 years.
  
  
  RESULTS
  More than 99% of the women had detectable levels of p,p-DDE (mean 9.10 ng/mL or ppb). Mean total PCB level was 7.56 ppb. Levels of exposure varied by geographical location and ethnic identification, which maybe a reflection of dietary differences. Five of the organochlorines were detected in at least half of the study population. Results were recalculated using detection limits corresponding to other published studies of DDE and PCB levels in U.S. women. Alaska women had levels similar to those reported from New York women collected in the 1980s. We compared the PCB congener levels measured in Alaska Native women with levels reported in Arctic animals and found similar PCB congener profiles. The six most frequently detected contaminants in Alaska Natives were also detected in the marine mammal samples reported by Becker et al (5).
  
  
  CONCLUSIONS
  Our study identified widespread Alaska Native exposure to organochlorines that originated outside of the Arctic, a finding also seen in other studies. Our results provide a reference baseline for exposure levels during the 1980s, but further research is necessary to assess temporal trends in exposure among Alaska Natives. Further, the need for national and international inter-laboratory standardization for testing for persistent organochlorines to facilitate comparisons between Alaska Natives and other American populations is clearly demonstrated.
authors.affiliation: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. chr1@cdc.gov
authors.forename: C H
authors.initials: CH
authors.lastname: Rubin
authors.forename: A
authors.initials: A
authors.lastname: Lanier
authors.forename: M
authors.initials: M
authors.lastname: Socha
authors.forename: J W
authors.initials: JW
authors.lastname: Brock
authors.forename: S
authors.initials: S
authors.lastname: Kieszak
authors.forename: S
authors.initials: S
authors.lastname: Zahm
mesh_terms: D000413:Alaska / Q000453:epidemiology; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D005260:Female; D005506:Food Contamination; D006305:Health Status Indicators; D006801:Humans; D007198:Indians, North American; D007306:Insecticides / Q000009:adverse effects* / Q000097:blood; D009369:Neoplasms / Q000139:chemically induced; D011078:Polychlorinated Biphenyls / Q000009:adverse effects* / Q000097:blood
chemical_list: D007306:Insecticides; D011078:Polychlorinated Biphenyls