title: Effect of prepyloric gastric transection and anastomosis on sphincter of Oddi cyclic motility in conscious dogs.
abstract: OBJECTIVE
  We previously reported significant changes in sphincter of Oddi cyclic motility after proximal duodenal transection and anastomosis. However, the role of intrinsic myoneural continuity between the antrum and duodenum in this respect is not understood. The aim of this study was to elucidate the effects of prepyloric gastric transection on sphincter of Oddi motility in animals in the conscious state.
  
  
  METHODS
  Pressures in the bile duct, duodenum, stomach, and sphincter of Oddi and their response to an injection of cholecystokinin-octapeptide were measured in four conscious dogs, with a duodenal cannula, before and after gastric transection and anastomosis 1.5 cm proximal to the pylorus.
  
  
  RESULTS
  Gastric transection did not affect the initiation and propagation of the gastroduodenal migration motor complex. Biliary pressure (5.7 +/- 0.15 to 5.5 +/- 0.2 mmHg; P = 0.91), sphincter of Oddi basal pressure (10.6 +/- 0.3 to 10.7 +/- 0.2 mmHg; P = 0.97), and amplitude (26.0 +/- 1.2 to 32.9 +/- 1.7 mmHg; P = 0.304) did not change after gastric transection. Biliary pressure decreased from phase II to phase III of the duodenal migrating motor complex. Cholecystokinin-octapeptide inhibited sphincter of Oddi phasic waves before and after gastric transection.
  
  
  CONCLUSIONS
  Intrinsic myoneural transection at the prepyloric region does not influence sphincter of Oddi cyclic motility. Preservation of pyloroduodenal myoneural continuity in pylorus-preserving gastrectomy would be beneficial to maintain normal sphincter of Oddi motility.
authors.affiliation: Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nabae
authors.forename: S
authors.initials: S
authors.lastname: Takahata
authors.forename: H
authors.initials: H
authors.lastname: Konomi
authors.forename: Z L
authors.initials: ZL
authors.lastname: Deng
authors.forename: K
authors.initials: K
authors.lastname: Yokohata
authors.forename: K
authors.initials: K
authors.lastname: Chijiiwa
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D003243:Consciousness; D004285:Dogs; D005743:Gastrectomy / Q000379:methods; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D011312:Pressure; D012844:Sincalide / Q000494:pharmacology*; D009803:Sphincter of Oddi / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D005765:Gastrointestinal Agents; D012844:Sincalide