Synthesis of novel derivatives of 1,4,7-triazacyclononane.
[structure: see text]. The coordination environment of 1,4,7-triazacyclononane can be adapted, through sequential functionalization of two secondary amines, to generate ligands applicable in biomimetic studies. Two "amino acids" and an amino derivative have been prepared from 1,4,7-triazatricyclo[5.2.1.0(4,10)]decane. This synthon allows efficient attachment of one functional group to the macrocyclic ring, forming a monoamidinium salt. Hydrolysis generates a formyl derivative, which was further functionalized at the secondary amine and hydrolyzed in strong acid to generate ligands 1-3.
Warden
A
A
Department of Chemistry, Monash University, 3800 Victoria, Australia.
Graham
B
B
Hearn
M T
MT
Spiccia
L
L