Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions.
A recently described one-day regimen of praziquantel (PZQ) therapy for neurocysticercosis (NCC), three doses of 25 mg/k given at 2 h intervals, was applied in eight patients with viable NCC cysts without any evidence of inflammation. Resolution of lesions in computed tomography (CT) was observed in all five patients with a single cyst, whereas all cysts survived in three patients with multiple brain parasites. One-day praziquantel is a good regimen for patients with a single viable brain cysticercus but is poorly effective for multiple cysts.
Pretell
E J
EJ
Department of Transmissible Diseases, Instituto Nacional de Ciencias Neurológicas, Jr. Ancash 1271, Barrios Altos, 1, Lima, Peru.
García
H H
HH
Gilman
R H
RH
Saavedra
H
H
Martinez
M
M
D000328:Adult; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003552:Cysticercus / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020019:Neurocysticercosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011223:Praziquantel / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D016896:Treatment Outcome
D000871:Anthelmintics; D011223:Praziquantel