Prognostic factors in hepatic metastases of colorectal carcinoma: immunohistochemical analysis of tumor biological factors.
The present study was designed to provide a systemic analysis of prognosis in 62 patients who underwent hepatic resection for colorectal liver metastasis. The analyzed factors included microvessel counts stained by CD34 and expression of two adhesion molecules, E-cadherin and CD44 variant exon 6-(v6) in these tumors. No significant factors related to recurrence were identified and only negative expression of CD44v6 tended to correlate with recurrence (P = 0.075). A short disease-free period to recurrence was noted in patients with high CEA levels (>10 ng/ml) and H2/3 classification. A short surgical margin, H2/3 classification, high microvessel counts (>60/field, x200), and negative expression of CD44v6 and E-cadherin tended to be associated with poor prognosis. A high microvessel count was the most significant prognostic factor by multivariate Cox proportional hazards regression model. Hepatic resection without tumor exposure and a careful follow-up in cases identified with poor prognostic factors are necessary.
Nanashima
A
A
First Department of Surgery, Nagasaki University School of Medicine, Japan.
Yamaguchi
H
H
Sawai
T
T
Yamaguchi
E
E
Kidogawa
H
H
Matsuo
S
S
Yasutake
T
T
Tsuji
T
T
Jibiki
M
M
Nakagoe
T
T
Ayabe
H
H
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D018952:Antigens, CD34 / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000032:analysis; D002277:Carcinoma / Q000098:blood supply / Q000737:chemistry / Q000401:mortality / Q000556:secondary*; D002448:Cell Adhesion; D015179:Colorectal Neoplasms / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000098:blood supply / Q000737:chemistry / Q000401:mortality / Q000556:secondary*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C112697:CD44v6 antigen; D015820:Cadherins; D006023:Glycoproteins; D018960:Hyaluronan Receptors