[Significance of determination of medium weight molecules in urine in normal pregnancy, in complicated pregnancy and in newborns with hypoxia].
Women with normal gestation and with gestosis and diabetes and newborns exposed to chronic intrauterine hypoxia were examined in order to elucidate the diagnostic value of measuring the content of low- and medium-weight molecules (MWM) in the urine in some obstetrical and gynecological abnormalities. Urinary content of MWM was increased at late terms of pregnancy (25-40 weeks). In first-degree nephropathy and type I diabetes without vascular complications the content of MWM in the urine did not change. A drop of MWM level was observed in second-third-degree nephropathy and proteinuria, which can be attributed to impaired function of the kidneys. In healthy newborns no differences in MWM content were detected during the first day of life, but in newborns exposed to chronic intrauterine hypoxia MWM level was increased. Hence, measurement of MWM level in the urine can have prognostic significance in diseases involving gestosis and fetal hypoxia.
Burmistrov
S O
SO
Gabelova
K A
KA
Andreeva
A A
AA
Oparina
T I
TI
Arutiunian
A V
AV
D015415:Biomarkers; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D016640:Diabetes, Gestational / Q000652:urine*; D005260:Female; D005311:Fetal Hypoxia / Q000652:urine*; D006801:Humans; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy / Q000652:urine*; D014118:Toxins, Biological / Q000652:urine*
D015415:Biomarkers; D014118:Toxins, Biological; C026865:uremia middle molecule toxins
Znachenie opredeleniia srednikh molekul v moche pri normal'noĭ i oslozhnennoĭ beremennosti i u novorozhdennykh s gipoksieĭ.