title: Pulmonary atresia with hypoplastic right ventricle. A clinical embryological study.
abstract: An unusual case of pulmonary atresia with an aberrant karyotype of 46,XX,t(6;8)(p21.2;q11.2) is reported. Fetal ultrasonic examination at the 20th week of gestation revealed a hypoplastic right ventricle and an intact interventricular septum. Authors summarize their postnatal findings in fetal heart and the large adjacent vessels with special reference to the pathogenesis of this rare congenital heart defect. The observation delineates right-ventricular outflow tract obstruction associated with an abnormal pulmonary blood supply. The anatomy of the systemic pulmonary collaterals was studied and correlated with multifocal disorders in the system of the pharyngeal arch arteries in the early embryonic development.
authors.affiliation: Institute of Anatomy, Friedrich Schiller University of Jena, Germany. rfro@mti-n.uni-jena.de
authors.forename: R
authors.initials: R
authors.lastname: Fröber
authors.forename: T
authors.initials: T
authors.lastname: Kohoutek
authors.forename: C
authors.initials: C
authors.lastname: Kähler
authors.forename: V
authors.initials: V
authors.lastname: Beensen
authors.forename: R
authors.initials: R
authors.lastname: Hauschild
authors.forename: E
authors.initials: E
authors.lastname: Schulze
authors.forename: W
authors.initials: W
authors.lastname: Linss
mesh_terms: D000649:Amniocentesis; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D020732:Cytogenetic Analysis; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D018633:Pulmonary Atresia / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014178:Translocation, Genetic; D016216:Ultrasonography, Prenatal