Leukaemia inhibitory factor abrogates Paclitaxel-induced axonal atrophy in the Wistar rat.
A prominent side effect of Paclitaxel chemotherapy is sensorimotor peripheral neuropathy. Leukaemia inhibitory factor (LIF) supports the survival and regrowth of axotomised sensory and motor neurons and we therefore investigated if systemically administered LIF abrogated Paclitaxel-induced neuropathy. We found that whereas animals administered Paclitaxel alone exhibited a significant decrease in the percentage of large myelinated axons, this reduction was prevented by the co-administration of LIF.
Kilpatrick
T J
TJ
The Walter and Eliza Hall Institute of Medical Research, Post Office, The Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia.
Phan
S
S
Reardon
K
K
Lopes
E C
EC
Cheema
S S
SS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001369:Axons / Q000187:drug effects* / Q000473:pathology; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002452:Cell Count; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions / Q000502:physiology*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000473:pathology; D006131:Growth Inhibitors / Q000494:pharmacology*; D007150:Immunohistochemistry; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000494:pharmacology*; D009410:Nerve Degeneration / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects / Q000473:pathology; D017239:Paclitaxel / Q000494:pharmacology*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013373:Substance P / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D006131:Growth Inhibitors; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide; D017239:Paclitaxel