title: The selective sigma(1) receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl)piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats.
abstract: We examined the effect of the sigma(1) receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl)piperazine (SA4503), on the acquisition of the conditioned place preference response to subcutaneously administered (-)-nicotine in rats. (-)-Nicotine, but not SA4503 or vehicle, produced a significant conditioned place preference response. Pretreatment of animals with either 1 or 3 mg/kg of SA4503 significantly attenuated the conditioned place preference response to (-)-nicotine.
authors.affiliation: Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
authors.forename: B
authors.initials: B
authors.lastname: Horan
authors.forename: E L
authors.initials: EL
authors.lastname: Gardner
authors.forename: S L
authors.initials: SL
authors.lastname: Dewey
authors.forename: J D
authors.initials: JD
authors.lastname: Brodie
authors.forename: C R
authors.initials: CR
authors.lastname: Ashby
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D018697:Nootropic Agents / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017480:Receptors, sigma / Q000819:agonists*; D000097605:Sigma-1 Receptor
chemical_list: D005731:Ganglionic Stimulants; D009538:Nicotine; D018697:Nootropic Agents; D010879:Piperazines; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor; C101789:SA 4503