Dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease.
There is increasing interest in the identification of biological markers for the early diagnosis of Parkinson's disease (PD). Previous studies indicate changes of dopamine content, tyrosine hydroxylase immunoreactivity and dopamine receptors in peripheral blood lymphocytes (PBL) in PD. Here we demonstrate a reduction of dopamine transporter immunoreactivity in PBL in the early clinical stages of the disease. These findings contribute to our understanding of the peripheral dopamine system in PD.
Caronti
B
B
Department of Neuroscience, University La Sapienza, Roma, Italy.
Antonini
G
G
Calderaro
C
C
Ruggieri
S
S
Palladini
G
G
Pontieri
F E
FE
Colosimo
C
C
D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D004298:Dopamine / Q000097:blood*; D050483:Dopamine Plasma Membrane Transport Proteins; D006801:Humans; D008214:Lymphocytes / Q000097:blood / Q000276:immunology*; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000097:blood / Q000276:immunology*; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010300:Parkinson Disease / Q000097:blood / Q000276:immunology*
D015415:Biomarkers; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D004298:Dopamine