Transdermal permeation of apomorphine through hairless mouse skin from microemulsions.
The in vitro transdermal absorption of apomorphine from microemulsions was studied using the skin of the hairless mouse as a membrane. Two microemulsions (no. 1 and 2) were prepared and thickened both containing 3.9% of apomorphine hydrochloride. The lipophilicity of the drug was increased by forming apomorphine-octanoic acid ion-pairs. The fluxes of the drug from the microemulsions through hairless mouse skin were 100 microg h(-1) cm(-2) from no. 1 and 88 microg h(-1) cm(-2) from no. 2. Apomorphine in microemulsions, protected from light with antioxidants, showed no degradation for up to 6 months.
Peira
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Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125 Turin, Italy.
Scolari
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Gasco
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D000279:Administration, Cutaneous; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004655:Emulsions; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D012869:Skin Absorption; D013678:Technology, Pharmaceutical
D018491:Dopamine Agonists; D004655:Emulsions; D001058:Apomorphine