A new guaianolide as apoptosis inhibitor from Chrysanthemum boreale.
The 8-O-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named borenolide, was isolated from Chrysanthemum boreale M. Borenolide inhibits the etoposide-induced apoptosis in U937 cell with an IC(50) value of 6.2 microg/ml. Structural assignment was based on NMR-spectroscopic methods and X-ray crystallographic analysis.
Lee
J R
JR
Yang
M S
MS
Jang
D S
DS
Ha
T J
TJ
Park
K M
KM
Lee
C H
CH
Kho
Y H
YH
Park
K H
KH
D017209:Apoptosis / Q000187:drug effects*; D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020298:U937 Cells
D012717:Sesquiterpenes; C438926:borenolide