Abnormal thermoregulation in drug-free male schizophrenia patients.
Schizophrenia patients may develop various thermoregulatory disturbances. We hypothesized that a standardized exercise-heat tolerance test [two 50-min bouts of walking a motor-driven treadmill at 40 degrees C (relative humidity=40%)] would reveal abnormal thermoregulation in drug-free schizophrenia patients. Six drug-free schizophrenia outpatients and seven healthy comparison subjects participated in this study. The schizophrenia patients exhibited significantly higher baseline and exertion-related rectal temperature. The relevance of these findings to the pathophysiology of schizophrenia-related thermoregulatory disorders is as yet unclear.
Shiloh
R
R
Geha Psychiatric Hospital, Felsenstein Medical Research Center, Beilinson Campus, Petah Tiqva, Israel.
Weizman
A
A
Epstein
Y
Y
Rosenberg
S L
SL
Valevski
A
A
Dorfman-Etrog
P
P
Wiezer
N
N
Katz
N
N
Munitz
H
H
Hermesh
H
H
D000328:Adult; D000704:Analysis of Variance; D001831:Body Temperature; D001833:Body Temperature Regulation; D005080:Exercise Test / Q000379:methods; D006339:Heart Rate; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000503:physiopathology*; D012881:Skin Temperature