title: LL-Z1271alpha: an interleukin-1beta production inhibitor.
abstract: LL-Z1271alpha, a fungal metabolite, dose-dependently inhibited interleukin-1beta (IL-1beta) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271alpha to LPS-challenged mice caused significant lowering in the IL-1beta levels in peritoneal cavity. Data presented suggest that LL-Z1271alpha inhibits IL-1beta production by a novel mechanism as the inhibitory activity was not due to effects on caspase-1 (IL-1beta converting enzyme), the ATP-induced release mechanism or a lysosomotrophic effect.
authors.affiliation: Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc., 5-Gochi Taketoyo-cho, Chita-gun, Aichi 470-2393, Japan. katsuomi ichikawa@japan.pfizer.com
authors.forename: K
authors.initials: K
authors.lastname: Ichikawa
authors.forename: T
authors.initials: T
authors.lastname: Inagaki
authors.forename: H
authors.initials: H
authors.lastname: Kachi-Tonai
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: Y
authors.initials: Y
authors.lastname: Ueno
authors.forename: P
authors.initials: P
authors.lastname: Binding
authors.forename: C A
authors.initials: CA
authors.lastname: Gabel
authors.forename: V
authors.initials: V
authors.lastname: Lucas
authors.forename: P A
authors.initials: PA
authors.lastname: McNiff
authors.forename: N
authors.initials: N
authors.lastname: Kojima
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D061945:Caspase Inhibitors; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D061945:Caspase Inhibitors; D007375:Interleukin-1; D008070:Lipopolysaccharides; D013729:Terpenes; C013363:LL-Z 1271alpha; D000255:Adenosine Triphosphate