[In vitro antimicrobial susceptibility of Helicobacter pylori strains: isolation of strains resistant to clarithromycin].
BACKGROUND
Our laboratory has carried out an epidemiological surveillance of Helicobacter pylori antimicrobial susceptibility since 1997.


OBJECTIVE
To report the antimicrobial susceptibility of H pylori strains, isolated in Chile from August 1997 to August 2000.


METHODS
Ninety one H pylori strains, obtained from antral gastric biopsies during upper gastrointestinal endoscopies were studied. Susceptibility towards clarithromycin, amoxicillin, bismuth subcitrate and metronidazole was studied by an agar diffusion technique.


RESULTS
All strains were susceptible to amoxicillin and two strains were resistant to clarithromycin. Forty two percent of strains were resistant to metronidazole and 13% were resistant to bismuth subcitrate.


CONCLUSIONS
These results underscore the need to maintain an epidemiological surveillance of H pylori antimicrobial susceptibility, to modify its eradication therapy accordingly.
González
C
C
Departamento de Microbiología, Facultad Clencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción, Chile. cgonzale@udec.cl
García
A
A
Daroch
F
F
Kawaguchi
F
F
Solar
H
H
Rivera
N
N
Vega
E
E
D000658:Amoxicillin / Q000494:pharmacology; D000863:Antacids / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001729:Bismuth / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology
D000863:Antacids; D000900:Anti-Bacterial Agents; D010406:Penicillins; D008795:Metronidazole; D000658:Amoxicillin; D017291:Clarithromycin; D001729:Bismuth
Susceptibilidad in vitro de cepas de Helicobacter pylori: aislamiento de cepas resistentes a claritromicina.