The effect of different immunosuppressants on alloantigen dependent and independent factors involved in the development of chronic rejection in an animal model.
The aim of this study was to compare the effects of cyclosporine, tacrolimus, mycophenolate mofetil and SDZ RAD on an animal model of transplant arteriosclerosis involving alloantigen dependent and independent mechanisms.
Cole
O
O
Transplant Unit, Nottingham City Hospital, Nottingham, UK.
Rigg
K
K
Shehata
M
M
D000818:Animals; D001012:Aorta, Abdominal / Q000637:transplantation; D001161:Arteriosclerosis / Q000276:immunology / Q000517:prevention & control; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use; D004195:Disease Models, Animal; D000068338:Everolimus; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007519:Isoantigens / Q000187:drug effects* / Q000276:immunology; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D020123:Sirolimus / Q000031:analogs & derivatives / Q000627:therapeutic use; D016559:Tacrolimus / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D007519:Isoantigens; D016572:Cyclosporine; D000068338:Everolimus; D009173:Mycophenolic Acid; D020123:Sirolimus; D016559:Tacrolimus