Dissociated functional recovery in parkinsonian monkeys following transplantation of astroglial cells.
Bilateral astroglial transplantation into the neostriatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys resulted in significant performance improvement in a spatial delayed response task, but failed to modify perseveration in an object retrieval detour task, or to improve motor clinical rating. Results suggest that brain circuits subserving various motor and cognitive performances can be functionally dissociated, and that remaining resources for the reorganization of neural circuits involved in spatial working memory performance in parkinsonian monkeys, appear to be responsive to striatal transplantation of subcultured, fetal striatal astroglial cells.
Lipina
S J
SJ
Unidad de Neurobiología Aplicada (UNA) (CEMIC-CONICET), Av. Galván 4102, 1431 Buenos Aires, Argentina.
Colombo
J A
JA
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism / Q000637:transplantation*; D001522:Behavior, Animal / Q000502:physiology; D016380:Brain Tissue Transplantation / Q000379:methods*; D002428:Cebus / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery*; D004185:Disability Evaluation; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D017072:Neostriatum / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009416:Nerve Regeneration / Q000502:physiology*; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D009483:Neuropsychological Tests; D020734:Parkinsonian Disorders / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011597:Psychomotor Performance / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D013028:Space Perception / Q000502:physiology; D014746:Vimentin / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin