title: Prospective randomized trial using laser acupuncture versus desmopressin in the treatment of nocturnal enuresis.
abstract: OBJECTIVE
  Several treatment modalities for children suffering from monosymptomatic nocturnal enuresis are available, but desmopressin is a well-established option. On the other hand, alternative nonpharmacological therapies such as laser acupuncture are more frequently requested by the parents. To our knowledge, there is no prospective randomized trial which evaluated the efficacy of such an alternative approach in comparison with the widespread use of desmopressin.
  
  
  METHODS
  Forty children aged over 5 years presenting with primary nocturnal enuresis underwent a previous evaluation of their voiding function to assure normal voiding patterns and a high nighttime urine production. Then the children were randomized into two groups: group A children were treated with desmopressin alone, and group B children underwent laser acupuncture. All children were investigated after a minimum follow-up period of 6 month to evaluate the duration of the response.
  
  
  RESULTS
  The children of both groups had an initial mean frequency of 5.5 wet nights per week. After a minimum follow-up period of 6 months reevaluation revealed a complete success rate of 75% in the desmopressin-treated group. Additional 10% of the children had a reduction of their wet nights of more than 50%. On the other hand, 6 months after laser acupuncture, 65% of the randomized children were completely dry. Another 10% had a reduction of the enuresis frequency of more than 50% per week. 20% of the children in the desmopressin-treated group did not respond at all as compared with 15% in the acupuncture-treated group. Statistical evaluation revealed no significant differences among the response rates in both groups.
  
  
  CONCLUSIONS
  Im comparison with pharmacological therapy using desmopressin, our study shows that laser acupuncture should be taken into account as an alternative, noninvasive, painless, cost-effective, and short-term therapy for children with primary nocturnal enuresis in case of a normal bladder function and high nighttime urine production. Success rates indicated no statistically significant differences between the well-established desmopressin therapy and the alternative laser acupuncture.
authors.affiliation: Department of Urology, University of Innsbruck, Austria. Christian.Radmayr@uibk.ac.at
authors.forename: C
authors.initials: C
authors.lastname: Radmayr
authors.forename: A
authors.initials: A
authors.lastname: Schlager
authors.forename: M
authors.initials: M
authors.lastname: Studen
authors.forename: G
authors.initials: G
authors.lastname: Bartsch
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D004775:Enuresis / Q000628:therapy*; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D011446:Prospective Studies; D012076:Renal Agents / Q000627:therapeutic use*
chemical_list: D012076:Renal Agents; D003894:Deamino Arginine Vasopressin