Phentolamine use in a neonate for the prevention of dermal necrosis caused by dopamine: a case report.
Skin ischemia, necrosis, and gangrene are uncommon but known complications of dopamine extravasation. In most cases, these complications are associated with the use of high-dosage dopamine infusion. Subcutaneous phentolamine has been used as a therapeutic agent for these complications. However, this is the report of the first neonatal case report in the English literature of prompt reversal of imminent dermal ischemia and necrosis associated with low-dose dopamine infusion using subcutaneous phentolamine.
Subhani
M
M
HSC 11-060, Division of Neonatology, Department of Pediatrics, SUNY at Stony Brook, Stony Brook, NY 11794-8111, USA.
Sridhar
S
S
DeCristofaro
J D
JD
D004298:Dopamine / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D007511:Ischemia / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009336:Necrosis; D010646:Phentolamine / Q000008:administration & dosage*; D012867:Skin / Q000098:blood supply* / Q000473:pathology
D004298:Dopamine; D010646:Phentolamine