title: Biotransformation of malachite green by the fungus Cunninghamella elegans.
abstract: The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 micromol x h(-1) (mg of cells)(-1). Malachite green was enzymatically reduced to leucomalachite green and also converted to N-demethylated and N-oxidized metabolites, including primary and secondary arylamines. Inhibition studies suggested that the cytochrome P450 system mediated both the reduction and the N-demethylation reactions.
authors.affiliation: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Cha
authors.forename: D R
authors.initials: DR
authors.lastname: Doerge
authors.forename: C E
authors.initials: CE
authors.lastname: Cerniglia
mesh_terms: D001673:Biodegradation, Environmental; D004396:Coloring Agents / Q000737:chemistry / Q000378:metabolism*; D003470:Culture Media; D020093:Cunninghamella / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D012394:Rosaniline Dyes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004396:Coloring Agents; D003470:Culture Media; D012394:Rosaniline Dyes; C005095:malachite green; D003577:Cytochrome P-450 Enzyme System