title: Pathological analysis of myocardial cell under ventricular tachycardia and fibrillation based on symbolic dynamics.
abstract: Ventricular fibrillation (VF) is one of the most serious malignant arrhythmias usually resulting from immediate degeneration of ventricular tachycardia (VT). In order to analyse the nonlinear dynamics of the cardiac micro-mechanism under VT and VT rhythm, at the cellular level, myocardial cell action potentials are investigated under different rhythm, normal sinus rhythm, VT and VT. On the basis of nonlinear chaotic theory and symbolic dynamics, we put forward new definitions, complexity rate, etc, and obtained some useful properties for cellular electrophysiological analysis. The results of the experiments and computation show that the myocardial cellular signals under VT and VF rhythm are different kinds of chaotic signals in that the cardiac chaos attractor under VF is higher than that under VT. The analytical complexity theory has been promising in the clinical application.
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Biotechnology, Shanghai Jiao Tong University, PR China. zhanghx@bme.situ.edu.ch
authors.forename: Z
authors.initials: Z
authors.lastname: Hongxuan
authors.forename: Z
authors.initials: Z
authors.lastname: Yisheng
authors.forename: X
authors.initials: X
authors.lastname: Yuhong
authors.forename: N V
authors.initials: NV
authors.lastname: Thakor
mesh_terms: D000200:Action Potentials; D000818:Animals; D002304:Cardiac Pacing, Artificial; D004594:Electrophysiology; D006321:Heart / Q000503:physiopathology*; D066298:In Vitro Techniques; D009206:Myocardium / Q000166:cytology; D017711:Nonlinear Dynamics; D011817:Rabbits; D017180:Tachycardia, Ventricular / Q000503:physiopathology*; D014693:Ventricular Fibrillation / Q000503:physiopathology*