Tolerogenic strategies to halt or prevent type 1 diabetes.
A variety of therapeutic strategies have been developed to tolerize autoreactive T cells and prevent autoimmune pathology. In terms of type 1 diabetes, prevention strategies can inhibit the priming and expansion of autoreactive T cells; however, a cure for diabetes would require tolerance to be established in the presence of primed effector cells together with replacement of the destroyed beta cell mass. Replacement of beta cells could be accomplished by transplantation of islets or stem cells or through islet regeneration. We will focus here on tolerogenic strategies that have been used to prevent onset of type 1 diabetes and discuss the potential for a cure.
Cooke
A
A
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. ac@mole.bio.cam.ac.uk
Phillips
J M
JM
Parish
N M
NM
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001324:Autoantigens / Q000627:therapeutic use; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology; D016381:Islets of Langerhans Transplantation; D051379:Mice; D018448:Models, Immunological; D009164:Mycobacterium Infections / Q000276:immunology; D010195:Pancreatitis / Q000473:pathology; D012555:Schistosomiasis mansoni / Q000276:immunology; D017634:Self Tolerance; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D001324:Autoantigens