The effects of elevated blood lead levels and succimer chelation therapy on physical growth in developing rhesus monkeys.
Seventy-two female rhesus monkeys were randomly assigned to three lead exposure conditions (none, birth to 1 year, birth to 2 years). In a completely crossed design, the lead-exposed and control monkeys were randomized to placebo or chelation therapy which began at 1 year of age. Dosing was conducted daily beginning on day 8 postpartum. The lead dose levels were adjusted biweekly to gradually elevate the blood lead level of each monkey to a target of 1.69-1.93 micromol/L (35-40 microg/dL). Succimer (or placebo) was administered orally (30 mg/kg/day for 5 days and 20 mg/kg/day for 14 additional days) for a total 19-day treatment regimen. There were two separate chelation regimes at 53 and 65 weeks of age. Succimer therapy in combination with lead abatement reduced blood lead levels significantly faster than lead abatement alone; however, that advantage disappeared once succimer therapy was discontinued. Weight, crown-rump length, and head circumference were measured regularly. Growth in weight, length, and head circumference did not vary significantly as a function of blood lead levels. Succimer chelation therapy did not significantly affect weight, length, or head circumference through 2 years of age.
Lasky
R E
RE
Center for Clinical Research and Evidence-Based Medicine, The University of Texas-Houston Medical School, Houston, Texas 77030, USA.
Laughlin
N K
NK
Luck
M L
ML
D000284:Administration, Oral; D000818:Animals; D001827:Body Height; D001835:Body Weight; D002614:Chelating Agents / Q000494:pharmacology*; D018592:Cross-Over Studies; D004781:Environmental Exposure; D005260:Female; D007854:Lead / Q000009:adverse effects*; D007855:Lead Poisoning / Q000188:drug therapy* / Q000662:veterinary; D008253:Macaca mulatta / Q000254:growth & development / Q000502:physiology; D011897:Random Allocation; D004113:Succimer / Q000494:pharmacology*; D016896:Treatment Outcome
D002614:Chelating Agents; D007854:Lead; D004113:Succimer