[Composition of neutrophil peroxisomes].
Peroxisomes of neutrophils are formed in promyelocytes. In addition to myeloperoxidase constituting 35% peroxisomes, they contain nonenzymatic antimicrobial cationic peptides and polypeptides, several serine proteases, as well as some other hydrolases and additional components. Similar to serine proteases, these hydrolases can serve as natural antibiotics. Their function can complement the main oxidation function of neutrophilic myeloperoxidase in the protective response. The peroxisomes contain acid glycosaminoglycans functioning as an anionic carrier that reversibly binds cationic proteins, including hydrolases.
Rogovin
V V
VV
Semenov Institute of Chemical Physics, Russian Academy of Sciences, Kosygina 4, Moscow, 117977 Russia.
Murav'ev
R A
RA
Mushtakova
V M
VM
D000818:Animals; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism* / Q000648:ultrastructure; D009195:Peroxidase / Q000378:metabolism; D020675:Peroxisomes / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism
D006025:Glycosaminoglycans; D009195:Peroxidase; D006867:Hydrolases; D012697:Serine Endopeptidases
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