On the use of Micro-Imager to directly visualize drug distribution in human skin.
Knowledge of drug distribution into the skin has always been considered as a key parameter of both safety and efficiency. We describe here the use of a new and powerful device to directly visualize and quantify the skin distribution of a radioactively labelled compound on histological sections.
Gautier
B
B
Life Sciences, L'Oréal Advanced Research Laboratories, Hair Research Group, Centre de Recherche C.-Zviak, Clichy, France.
Bernard
B A
BA
D015194:Diffusion Chambers, Culture; D004817:Epidermis / Q000000981:diagnostic imaging / Q000378:metabolism; D018859:Hair Follicle / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D014677:Pharmaceutical Vehicles; D011877:Radionuclide Imaging; D012588:Scintillation Counting / Q000295:instrumentation*; D012867:Skin / Q000000981:diagnostic imaging* / Q000378:metabolism; D012869:Skin Absorption / Q000502:physiology*
D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles