Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia.
A total of 47 Caucasian duodenal ulcer patients and 680 healthy persons were investigated for HLA antigens of classes I and II. HLA antigens of the A, B series were sought using the microlymphocytotoxicity test, and HLA-DRBI was analysed by polymerase chain reaction. The study found associations of duodenal ulcer with HLA-A10, -B41 and different combinations of these alleles, whereas HLA-A9 was found to be protective. A relative risk of peptic ulcer was 3.03 in HLA-A10 (pcor < 0.05), and 7.78 in HLA-B41 (p < 0.001). The allele frequency A9 was higher in healthy controls (30.15%) than in Helicobacter pylori-positive patients with duodenal ulcer (10.64%, RR = 3.50, pcor < 0.05). The study showed that frequencies of alleles HLA-DR7 and HLA-A1/B12 were higher in Helicobacter pylori-positive duodenal ulcer patients with family history of peptic ulcer (RR = 4.00 and RR = 11.92, respectively p < 0.05). These data suggest that HLA may influence duodenal ulcer susceptibility and resistance, and according to the high prevalence of Helicobacter pylori (HP) infection in Siberian population (87.5%), this may occur through a non-HP infection pathway.
Kurilovich
S A
SA
Institute of Internal Medicine, Institute of Clinical Immunology, RMA, Novosibirsk, Russia Vladimirovsky spusk, 2a, 630003 Novosibirsk, Russia. ksa@itr.nsu.ru
Shlykova
L G
LG
Konenkov
V I
VI
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004198:Disease Susceptibility / Q000276:immunology*; D004381:Duodenal Ulcer / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics / Q000276:immunology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012800:Siberia; D044465:White People / Q000235:genetics*
D006680:HLA Antigens