title: Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.
abstract: The OBJECTIVE of this research was to investigate the regulatory effect of Epitalon on the production of melatonin and cortisol in senescent monkeys.
  
  
  METHODS
  We investigated the character of melatonin and cortisol secretion by immunoferment assay in Epitalon-administered female Macaca mulatta in different age periods.
  
  
  RESULTS
  Epitalon was proven to significantly stimulate melatonin synthesis in senescent monkeys in the evening, thereby normalising the circadian rhythm of cortisol secretion.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo Prospect, 197110 St. Petersburg, Russia. ibg@medport.ru
authors.forename: V
authors.initials: V
authors.lastname: Khavinson
authors.forename: N
authors.initials: N
authors.lastname: Goncharova
authors.forename: B
authors.initials: B
authors.lastname: Lapin
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002940:Circadian Rhythm; D004700:Endocrine System Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D008253:Macaca mulatta; D008550:Melatonin / Q000097:blood; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D009842:Oligopeptides / Q000627:therapeutic use*; D009994:Osmolar Concentration
chemical_list: D009842:Oligopeptides; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine