title: A comparison of two methods of evaluating cornea-to-contact lens base curve fluorescein patterns in keratoconus.
abstract: OBJECTIVE
  The purposes of the study were as follows: (1) to compare the apical fitting relationship of habitual contact lens fluorescein patterns in keratoconus as determined by clinician assessment of on-eye patterns to those determined by photograph readers looking at slides of fluorescein patterns and (2) to determine the validity of the techniques used in assessing the apical fitting relationships of rigid corneal contact lenses on keratoconic corneas.
  
  
  METHODS
  Central fluorescein patterns of rigid contact lens-wearing keratoconus patients enrolled in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study were graded as "definite touch," "touch," "clearance," or "definite clearance" by certified clinicians. Photographs of these patterns were evaluated independently by certified, masked photograph readers using the same grading scale.
  
  
  RESULTS
  Agreement between "re-reads" of the same fluorescein pattern slides by the photograph readers was substantial (weighted kappa = 0.751). Agreement between assessments of habitual fit fluorescein patterns at the baseline vs. the repeat visits was poor for the photograph readers (weighted kappa = 0.254) and moderate for the clinicians (kappa = 0.480). Agreement between clinicians' and photograph readers' assessment of the habitual contact lens fluorescein pattern at the baseline visit was fair (weighted kappa = 0.382).
  
  
  CONCLUSIONS
  Repeatability and validity of this technique were fair to excellent. Many factors influence fluorescein pattern interpretation, and improvement of the objective method of fluorescein pattern assessment by photograph readers will require improved methodology that takes these factors into consideration.
authors.affiliation: The Ohio State University College of Optometry, Columbus 43210-1240, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Fink
authors.forename: J T
authors.initials: JT
authors.lastname: Barr
authors.forename: T B
authors.initials: TB
authors.lastname: Edrington
authors.forename: G E
authors.initials: GE
authors.lastname: Pierce
authors.forename: K B
authors.initials: KB
authors.lastname: Schechtman
authors.forename: M J
authors.initials: MJ
authors.lastname: Rah
authors.forename: R
authors.initials: R
authors.lastname: Flom
authors.forename: K
authors.initials: K
authors.lastname: Zadnik
mesh_terms: D003261:Contact Lenses; D003287:Contrast Media; D003315:Cornea / Q000473:pathology*; D019793:Fluorescein; D006801:Humans; D007640:Keratoconus / Q000473:pathology* / Q000628:therapy; D015588:Observer Variation; D010781:Photography; D017755:Prosthesis Fitting; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D019793:Fluorescein