Fatal acute diclofenac-induced immune hemolytic anemia.
We report the case of a 72-year-old woman who developed fatal immune hemolytic anemia with multisystem organ failure and shock caused by diclofenac-dependent red blood cell autoantibodies. The patient described dramatically illustrates the potential severity of this adverse reaction and emphasizes the need for increased awareness of this complication of drug therapy.
Jürgensen
J S
JS
Medizinische Klinik mit Schwerpunkt Nephrologie und internistische Intensivmedizin, Humboldt-Universität zu Berlin, Germany. jan_steffen.juergensen@charite.de
Seltsam
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Jörres
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D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D004008:Diclofenac / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009102:Multiple Organ Failure / Q000276:immunology; D012769:Shock / Q000276:immunology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001323:Autoantibodies; D004008:Diclofenac