The neuropeptide pituitary adenylate cyclase-activating polypeptide and islet function.
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is ubiquitously distributed in both the central and peripheral nervous systems and exerts a variety of effects. PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a parasympathetic and sensory neurotransmitter. PACAP stimulates insulin secretion in a glucose-dependent manner, by an effect executed mainly through augmenting the formation of cAMP and stimulating the uptake of calcium. Accumulating evidence in animal studies points to a physiological importance of PACAP in the regulation of the insulin response to feeding. This review summarizes the current knowledge of islet actions and mechanisms and the function of PACAP.
Filipsson
K
K
Department of Medicine, Lund University, Lund, Sweden.
Kvist-Reimer
M
M
Ahrén
B
B
D000818:Animals; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007515:Islets of Langerhans / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D015398:Signal Transduction
C495401:ADCYAP1 protein, human; D006728:Hormones; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide