title: Role of the medial and lateral caudate-putamen in mediating an auditory conditional response association.
abstract: Rats with quinolinic acid lesions of the medial or lateral caudate-putamen (CPu) and controls were tested for performance of a previously learned auditory conditional response association task. The task involved the selection of two possible responses when presented with one of two different tones. Results indicated that lesions of either the medial or the lateral CPu produced a sustained deficit in the auditory conditional response association task. Only the lateral CPu lesioned rats exhibited transient motor problems immediately following surgery, but these problems did not interfere with the execution of the appropriate responses. It is suggested that both the medial and the lateral CPu are involved in response selection and response separation within egocentric space.
authors.affiliation: Department of Psychology, University of Utah, Salt Lake City 84112-0251, USA.
authors.forename: S
authors.initials: S
authors.lastname: Adams
authors.forename: R P
authors.initials: RP
authors.lastname: Kesner
authors.forename: M E
authors.initials: ME
authors.lastname: Ragozzino
mesh_terms: D000818:Animals; D001245:Association Learning / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001522:Behavior, Animal / Q000502:physiology; D002421:Caudate Nucleus / Q000187:drug effects / Q000503:physiopathology*; D003213:Conditioning, Psychological; D008297:Male; D011596:Psychomotor Disorders / Q000139:chemically induced; D011699:Putamen / Q000187:drug effects / Q000503:physiopathology*; D017378:Quinolinic Acid / Q000009:adverse effects; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D017378:Quinolinic Acid