[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema].
Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. In the presented work we investigated the efficacy and safety of a climbazole 0.65% shampoo on seborrheic dermatitis of 30 volunteers. Subjects were diagnosed as having moderate to severe seborrheic dermatitis of the scalp. After a 1-week washout and a 4-week treatment the clinical evaluation showed a successful reduction of dandruff, skin redness and itching in 80% of the volunteers and a mild improvement in 20% of the volunteers. The cosmetic acceptability was very good by the majority. It is concluded that the formulation tested is effective in the treatment of moderate to severe dandruff.
Wigger-Alberti
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Klinik für Dermatologie und dermatologische Allergologie, Friedrich-Schiller-Universität, Jena.
Kluge
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Elsner
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D000328:Adult; D012628:Dermatitis, Seborrheic / Q000188:drug therapy*; D003881:Dermatomycoses / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006203:Hair Preparations; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D008290:Malassezia / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D006203:Hair Preparations; D007093:Imidazoles; C108286:climbazole
Klinische Wirksamkeit und Verträglichkeit eines Climbazol-haltigen Antischuppen-Shampoos bei Patienten mit seborrhoischem Kopfhautekzem.