Oxytocin decreases carrageenan induced inflammation in rats.
The effects of oxytocin on carrageenan-induced inflammation in rat hindpaw was examined. Oxytocin at 100 (P < 0.05) and 1000 microg/kg s.c. (P < 0.05), but not at 1 and 10 microg/kg s.c., reduced the edema of the paw when measured up to 10 h after the injection. An additional experiment showed that the effect was comparable to the effect of the glucocorticoid dexamethasone. No effect was found by oxytocin i.c.v. In addition, rats with carrageenan-induced inflammation given oxytocin (1000 microg/kg s.c.) responded differently to nociceptive mechanical stimulation (P < 0.05) and had a reduced amount of myeloperoxidase (marker for neutrophil recruitment) in the paw (P < 0.01).
Petersson
M
M
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. maria.petersson@fyfa.ki.se
Wiberg
U
U
Lundeberg
T
T
Uvnäs-Moberg
K
K
D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000187:drug effects; D002351:Carrageenan / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004487:Edema / Q000139:chemically induced / Q000378:metabolism; D006614:Hindlimb; D006727:Hormone Antagonists / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced* / Q000378:metabolism; D007273:Injections, Intramuscular; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D017288:Pain Threshold / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014668:Vasotocin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*
D015415:Biomarkers; D006727:Hormone Antagonists; C047046:atosiban; D010121:Oxytocin; D003907:Dexamethasone; D002351:Carrageenan; D009195:Peroxidase; D014668:Vasotocin