title: Tissue-specific alterations in lipoprotein lipase activity in copper-deficient rats.
abstract: Copper deficiency results in alterations in lipid metabolism that include elevations in serum cholesterol and triglycerides and a decrease in whole-body respiratory quotient. Copper-deficient animals are also leaner even though electron micrographs of the myocardium present increased lipid droplet accumulation. To address whether a compromised copper status impacts triglyceride deposition in a tissue-specific manner, the activity of lipoprotein lipase was measured in adipose tissue and cardiac and skeletal muscle. Weanling rats fed a copper-restricted diet (<1 ppm) for 6 wk demonstrated a greater than twofold increase in cardiac lipoprotein lipase activity concomitant with a significant reduction in adipose tissue lipoprotein lipase activity. Skeletal muscle lipoprotein lipase activity was not altered by the copper-deficient state. The results of this study suggest that copper deficiency may induce a tissue-specific alteration in lipoprotein lipase activity in rats, which may contribute to the notable deposition of lipid substance in myocardium and the concomitant general body leanness.
authors.affiliation: University of Louisiana at Lafayette, 70504-0399, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Wildman
authors.forename: S
authors.initials: S
authors.lastname: Mao
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology*; D000740:Anemia / Q000150:complications / Q000201:enzymology; D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003300:Copper / Q000172:deficiency*; D004032:Diet; D006937:Hypercholesterolemia / Q000150:complications / Q000201:enzymology; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D009929:Organ Size; D009928:Organ Specificity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013851:Thinness / Q000150:complications / Q000201:enzymology; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D014280:Triglycerides; D003300:Copper; D002784:Cholesterol; D008071:Lipoprotein Lipase