Synthesis and reactivity of a 5-azido analogue of neuraminic acid.
A peracetylated phenyl 2-thioglycoside (1) of a 5-azido analogue neuraminic acid methyl ester was prepared from a known 5-amino precursor by a diazo transfer reaction. Glycosidation of 1 by alcohols proceeded smoothly in CH3CN to give alpha-sialylated products in good yield.
Matsuoka
K
K
Department of Functional Materials Science, Faculty of Engineering, Saitama University, Urawa, Japan. koji@fms.saitama-u.ac.jp
Oka
H
H
Terunuma
D
D
Kuzuhara
H
H