title: PDZ proteins and polarity: functions from the fly.
abstract: Proteins that contain PDZ domains have been implicated in the localization of interacting partners to specific regions of the cell membrane. Although PDZ proteins that bind to a number of important mammalian proteins have been isolated, the significance of these interactions is unclear. In recent years, the fruit fly has emerged as a rich system for genetic analysis of PDZ protein function. Here, I discuss what the Drosophila data tell us about the roles and mechanisms of PDZ protein activity, and how this informs our understanding of PDZ function in other organisms.
authors.affiliation: Dept of Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA. bilder@rascal.med.havard.edu
authors.forename: D
authors.initials: D
authors.lastname: Bilder
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000235:genetics; D016764:Cell Polarity / Q000235:genetics*; D020732:Cytogenetic Analysis; D004330:Drosophila / Q000196:embryology* / Q000235:genetics* / Q000254:growth & development; D006801:Humans; D007150:Immunohistochemistry; D019476:Insect Proteins / Q000737:chemistry*; D009154:Mutation; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D019476:Insect Proteins