title: Spinal-cord compression due to extradural amyloidosis of the cervico-occipital hinge, in a hemodialysed patient. A case report.
abstract: Long-term dialysed patients can develop an arthropathy, called dialysis arthropathy, due to the deposition and transformation of the beta2 microglobulin into amyloid. The involvement of the spine, called destructive spondyloarthropathy (DSA), occurs between 10 and 25 percent; of these patients, and sometimes causes neurological damage. The disc space narrowing, vertebral body erosion and pseudocystis, in presence of polyarthropathy, chronic renal failure, and carpal tunnel syndrome, allows to make a diagnosis of DSA, which is proved by histological finding of beta2 microglobulin-amyloid. We report a rare case of spinal cord compression due to beta2 microglobulin-amyloid deposit in extradural space of cervico-occipital hinge.
authors.affiliation: Neurosurgical Unit, Umberto I Hospital, ASL Salerno 1, Nocera, Salerno, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Amoroso
authors.forename: C
authors.initials: C
authors.lastname: Vitale
authors.forename: A
authors.initials: A
authors.lastname: Silvestro
mesh_terms: D000328:Adult; D000682:Amyloid / Q000097:blood; D000686:Amyloidosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D001268:Atlanto-Axial Joint / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D001269:Atlanto-Occipital Joint / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D019299:Decompression, Surgical / Q000379:methods; D004388:Dura Mater / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D015174:Epidural Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007796:Laminectomy / Q000379:methods; D008279:Magnetic Resonance Imaging; D020127:Recovery of Function / Q000502:physiology; D006435:Renal Dialysis / Q000009:adverse effects*; D013116:Spinal Cord / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D013117:Spinal Cord Compression / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000682:Amyloid