title: Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones.
abstract: [reaction: see text]. The solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones from resin-bound amino acids is described. The exhaustive reduction of solid-support bound amides with borane afforded the requisite secondary amines, which following treatment with phenyl isocyanatoformate and cleavage, provided the corresponding triazepane-2,4-diones.
authors.affiliation: Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: J M
authors.initials: JM
authors.lastname: Ostresh
authors.forename: R A
authors.initials: RA
authors.lastname: Houghten
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D001880:Boranes / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D000596:Amino Acids; D001381:Azepines; D001880:Boranes