title: [Depakene (sodium valproate) in the treatment of epilepsy in children and adolescents: efficiency and safety].
abstract: 375 patients 7 months-19 years of age with different forms of epilepsy were treated with depakine. High efficiency of the drug was found in all forms of children's epilepsy. A complete remission was observed in 60% of the patients, a good effect--in 19%, a satisfactory effect--in 15%, 6%--were non-responders. The highest efficiency of depakine was achieved in idiopathic forms of epilepsy (complete remission--in 74% of the cases) and, therefore, depakine can be used as a monotherapy. Meanwhile, the efficiency of depakine was lower in cryptogenic generalized and symptomatic partial epilepsy. In such cases depakine should be used as a basic preparation in polytherapy. Side effects were observed in 35% of the cases, but stopping of therapy was necessary only in 25% of such cases. Rare idiosyncrasy and no negative influence on the cognitive functions were important-properties of depakine.
authors.forename: A S
authors.initials: AS
authors.lastname: Petrukhin
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Mukhin
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016896:Treatment Outcome; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid
vernacular_title: Depakin (val'proat natriia) v lechenii épilepsii u deteĭ i podrostkov: éffektivnost' i perenosimost'.