Arthus reaction to recombinant hepatitis B virus vaccine.
A severe, local, inflammatory, late-phase reaction accompanied by skin necrosis occurred after an infant was given an intramuscular injection of recombinant hepatitis B virus vaccine. The clinical course and appearance of the rash were typical of an Arthus reaction. Although not identical to this case, prior reported cases of complement-mediated reactions occurring after hepatitis B virus infection or vaccination provide theoretical support for this diagnosis.
Froehlich
H
H
Department of Pediatrics, Kaiser Permanente Medical Center, Fresno, CA, USA. froehlich.h@ghc.org
Verma
R
R
D001183:Arthus Reaction / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D003167:Complement Activation; D005260:Female; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D014614:Vaccines, Synthetic / Q000009:adverse effects*
C075654:Engerix-B; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic