title: Imidazolopyrazinones as potential antioxidants.
abstract: A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree-Fock instabilities have been examined.
authors.affiliation: Unité de Chimie organique et médicinale, Université catholique de Louvain, Bâtiment Lavoisier, place L. Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Devillers
authors.forename: G
authors.initials: G
authors.lastname: Dive
authors.forename: C
authors.initials: C
authors.lastname: De Tollenaere
authors.forename: B
authors.initials: B
authors.lastname: Falmagne
authors.forename: B
authors.initials: B
authors.lastname: de Wergifosse
authors.forename: J F
authors.initials: JF
authors.lastname: Rees
authors.forename: J
authors.initials: J
authors.lastname: Marchand-Brynaert
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007093:Imidazoles; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011719:Pyrazines / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry; D017382:Reactive Oxygen Species; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D007093:Imidazoles; D011719:Pyrazines; D011720:Pyrazoles; D017382:Reactive Oxygen Species; D013481:Superoxides; C017144:coelenterazine