title: Spontaneous remission in a secondary acute myelogenous leukaemia following invasive pulmonary aspergillosis.
abstract: Spontaneous remission of adult acute myelogenous leukaemia (AML) represents a rare event. We report a 60-year-old female patient suffering from secondary AML M1 and severe invasive pulmonary hyalohyphomycosis highly suggestive of aspergillosis. Two months after the diagnosis of leukaemia, she achieved a spontaneous remission lasting 3 months, although neither cytostatic drugs nor corticoids were administered because of a septic condition. At the time of remission, a chronic hepatitis C virus infection and a polyclonal hypergammaglobulinaemia were present, and the patient received granulocyte colony-stimulating factor once. This report represents the first documentation of a spontaneous remission in AML following invasive pulmonary hyalohyphomycosis. Possible mechanisms of this phenomenon are discussed.
authors.affiliation: Institute of Pathology, Innsbruck, Austria. alexandar.tzankov@uibk.ac.at
authors.forename: A
authors.initials: A
authors.lastname: Tzankov
authors.forename: C
authors.initials: C
authors.lastname: Ludescher
authors.forename: H C
authors.initials: HC
authors.lastname: Duba
authors.forename: M
authors.initials: M
authors.lastname: Steinlechner
authors.forename: R
authors.initials: R
authors.lastname: Knapp
authors.forename: T
authors.initials: T
authors.lastname: Schmid
authors.forename: K
authors.initials: K
authors.lastname: Grünewald
authors.forename: G
authors.initials: G
authors.lastname: Gastl
authors.forename: R
authors.initials: R
authors.lastname: Stauder
mesh_terms: D001228:Aspergillosis / Q000150:complications*; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000150:complications*; D008875:Middle Aged; D012075:Remission, Spontaneous; D014057:Tomography, X-Ray Computed