Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues.
A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP).
Dankwardt
S M
SM
Roche Bioscience, Inflammatory Diseases Unit, 3401 Hillview Ave, Palo Alto, CA 94304, USA. sharon.dankwardt@roche.com
Martin
R L
RL
Chan
C S
CS
Van Wart
H E
HE
Walker
K A
KA
Delaet
N G
NG
Robinson
L A
LA
D000596:Amino Acids / Q000737:chemistry; D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009952:Ornithine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000596:Amino Acids; D019485:Bone Morphogenetic Proteins; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D013449:Sulfonamides; D009952:Ornithine; D008666:Metalloendopeptidases; D055395:Bone Morphogenetic Protein 1