title: In vitro activity of a novel ketolide ABT-773 against invasive strains of Streptococcus pneumoniae.
abstract: New ketolides such as ABT-773 are a promising group of antibiotics in an era of increasing antibiotic resistance. We tested 704 invasive strains of Streptococcus pneumoniae collected from 1990 to 1998. Overall resistance was 8.3, 4.6, 4.5 and 3.6% for penicillin, cefuroxime, erythromycin and clarithromycin, respectively. By using a recommended breakpoint for susceptibility of <0.5 mg/L, no strains showed reduced susceptibility to ABT-773. ABT-773 was very active against all penicillin-resistant strains (MIC > 2 mg/L, with a mean geometric mean <0.06 mg/L), and against all 33 erythromycin-resistant strains, irrespective of the mode of resistance [mef- or erm(B)-mediated]. ABT-773 is a very active and promising agent against invasive strains of S. pneumoniae, including multiresistant strains.
authors.affiliation: Hôpital Maisonneuve-Rosemont, University of Montreal, 5415 L'Assomption, Montreal, Quebec H1T 2M4, Canada. weisscan@aol.com
authors.forename: K
authors.initials: K
authors.lastname: Weiss
authors.forename: J
authors.initials: J
authors.lastname: de Azavedo
authors.forename: C
authors.initials: C
authors.lastname: Restieri
authors.forename: C
authors.initials: C
authors.lastname: Quach
authors.forename: M
authors.initials: M
authors.lastname: Laverdiere
authors.forename: E
authors.initials: E
authors.lastname: Rubin
authors.forename: M
authors.initials: M
authors.lastname: Gourdeau
authors.forename: D E
authors.initials: DE
authors.lastname: Low
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004351:Drug Resistance; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D048628:Ketolides; D008826:Microbial Sensitivity Tests; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D004917:Erythromycin; C405499:cethromycin