EGF receptors as transcription factors: ridiculous or sublime?
The notion that a transmembrane receptor at the cell surface can somehow reappear as a transcription factor in the nucleus is bound to be controversial. However, there are two reported examples of this. If this hypothesis can withstand the inevitable and necessary battery of additional empirical tests, then our understanding of signal transduction needs to move in a new direction.
Waugh
M G
MG
Centre for Molecular Cell Biology, Department of Medicine, Royal Free and University College Medical School, Royal Free Campus, Hampstead, London, NW3 2PF, UK. m.waugh@rfc.ucl.ac.uk
Hsuan
J J
JJ
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000378:metabolism*; D066246:ErbB Receptors / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D021381:Protein Transport; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors; D066246:ErbB Receptors