title: Risk factors influencing early and late mortality after total cavopulmonary connection.
abstract: OBJECTIVE
  Among the later modifications of the Fontan type procedure, a significant alteration was introduced by de Leval and associates when they described the total cavopulmonary connection (TCPC). Although current results of TCPC have encouraged us to extend this procedure to high risk patients, risk factors influencing surgical outcome after TCPC have not been evaluated. We review our experiences with TCPC to identify which risk factors may have had a considerable impact on the outcome of patients undergoing TCPC and to clarify selection criteria of high-risk Fontan candidates for TCPC.
  
  
  METHODS
  We retrospectively reviewed the medical and surgical records of all 76 patients who underwent TCPC between July 1988 and August 2000. A cross-sectional review of these patients was undertaken.
  
  
  RESULTS
  There were eight early deaths and four late deaths. In a Fisher's exact test, the following variables were associated with an increased early mortality after TCPC: systemic ventricular morphology (right ventricle), ejection fraction of the systemic ventricle less than 60%, and prolonged cardiopulmonary bypass time (240 min or longer). The log-rank test demonstrated that heterotaxy syndrome, moderate to severe atrioventricular valve regurgitation, prolonged cardiopulmonary bypass time (240 min or longer), and prolonged aortic cross clamp time (70 min or longer) were associated with late mortality after TCPC. Six deaths occurred in eight (75%) patients who had six or more risk factors, whereas six deaths (9%) occurred in those who had five or fewer.
  
  
  CONCLUSIONS
  Patients with complex cardiac anomalies who have six or more risk factors should be excluded from TCPC candidates.
authors.affiliation: Department of Cardiothoracic Surgery, Kobe Children's Hospital, Kobe, Japan. y-naoki@za2.so-net.ne.jp
authors.forename: N
authors.initials: N
authors.lastname: Yoshimura
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Oshima
authors.forename: S
authors.initials: S
authors.lastname: Oka
authors.forename: Y
authors.initials: Y
authors.lastname: Ootaki
authors.forename: T
authors.initials: T
authors.lastname: Tei
authors.forename: S
authors.initials: S
authors.lastname: Kido
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018610:Heart Bypass, Right / Q000401:mortality*; D006330:Heart Defects, Congenital / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D012189:Retrospective Studies; D012307:Risk Factors