title: The centromeric part of the human natural killer (NK) receptor complex: lectin-like receptor genes expressed in NK, dendritic and endothelial cells.
abstract: The human natural killer (NK) receptor complex encompasses a region of about 2 Mb on the short arm of chromosome 12. It contains at least 18 lectin-like receptor genes, of which some are expressed in NK and NK/T cells and function as NK receptors. Close to the CD94 and NKG2 NK receptor genes in the centromeric part, a novel family of genes, expressed in myeloid, dendritic and/or endothelial cells, recently became evident. These genes encode a receptor for oxidized low density lipoprotein in endothelial cells and three other receptors potentially serving regulatory functions in dendritic cells. Although the overall structure of the human NK receptor complex is similar to the syntenic rodent regions, the centromeric part lacks the cluster of Ly49 genes. This supports the notion that recognition of MHC class Ia molecules has evolved separately in rodents and humans in the lectin-like Ly49 and the killer immunoglobulin-like receptors, respectively. In the telomeric part, other lectin-like genes expressed in different hematopoietic lineages are found. The receptors of the NK receptor complex apparently serve important functions in several leukocytes and in endothelial cells, and the exact role of these receptors, their ligands, and their distinct and co-ordinate regulation in different cell lineages warrants further investigation.
authors.affiliation: Department of Vascular Biology and Thrombosis Research, Vienna International Research Cooperation Center, University of Vienna, Austria. erhard.hofer@univie.ac.at
authors.forename: E
authors.initials: E
authors.lastname: Hofer
authors.forename: Y
authors.initials: Y
authors.lastname: Sobanov
authors.forename: C
authors.initials: C
authors.lastname: Brostjan
authors.forename: H
authors.initials: H
authors.lastname: Lehrach
authors.forename: M
authors.initials: M
authors.lastname: Düchler
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D000950:Antigens, Ly; D002503:Centromere / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D003713:Dendritic Cells / Q000276:immunology; D004727:Endothelium / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D037102:Lectins / Q000235:genetics; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins / Q000235:genetics; D005810:Multigene Family; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D020161:Physical Chromosome Mapping; D011971:Receptors, Immunologic / Q000235:genetics; D011973:Receptors, LDL / Q000235:genetics; D011975:Receptors, Mitogen / Q000235:genetics*; D055630:Receptors, NK Cell Lectin-Like; D055607:Receptors, Natural Killer Cell; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E; D016615:Telomere / Q000235:genetics
chemical_list: D015703:Antigens, CD; D000950:Antigens, Ly; C527054:KLRC1 protein, human; C497869:KLRD1 protein, human; D037102:Lectins; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; C495137:OLR1 protein, human; D011971:Receptors, Immunologic; D011973:Receptors, LDL; D011975:Receptors, Mitogen; D055630:Receptors, NK Cell Lectin-Like; D055607:Receptors, Natural Killer Cell; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E