[Autoantibodies to NMDA-type glutamate receptors in the blood of patients with acute ischemic and hemorrhagic stroke].
The characteristics of accumulation of autoantibodies (aAbs) on NMDA-type glutamate receptors were studied in blood of patients at different stages (1-4 days, 5-7 days, 8-14 days, up to 28 days) of acute period of ischemic or hemorrhagic stroke. The stability of low values (1.29 +/- 0.31 ng/ml) of the titer of aAbs to NMDA-receptors was revealed in patients with acute cerebral hemorrhage. Two types of titer of Abs to NMDA-receptors were revealed in case with cerebral ischemia. The undulating nature of Abs titer changes was revealed in acute ischemic strokes caused by hypertension and cerebral atherosclerosis (from 2.23 +/- 0.53 ng/ml on the 1-st day with increase up to 3.23 +/- 0.90 ng/ml and up to the 3-4 day), following fluctuations with less pronounced increase on 7-8th day were found out. High titer of aAbs to NMDA-receptors (up to 10.0 ng/ml) were observed on 3-4th day in cases of acute ischemic strokes on the background of chronic alcohol encephalopathy caused by intoxication or dysmetabolism with their retention up to 10-14th day.
Skoromets
A A
AA
Dambinova
S A
SA
Iliukhina
A Iu
AIu
Sorokoumov
V A
VA
D000208:Acute Disease; D000328:Adult; D000368:Aged; D019973:Alcohol-Related Disorders / Q000150:complications; D001323:Autoantibodies / Q000097:blood*; D002545:Brain Ischemia / Q000097:blood / Q000209:etiology / Q000276:immunology; D002543:Cerebral Hemorrhage / Q000097:blood / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D002537:Intracranial Arteriosclerosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000276:immunology*; D013997:Time Factors
D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate
Autoantitela k glutamatnym retseptoram NMDA-tipa v krovi patsientov s ostrym ishemicheskim i gemorragicheskim insul'tom.