title: Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma.
abstract: Elevated systemic levels of S-100B are proposed as a potential indicator of brain damage in identifying high-risk patients after mild head trauma (MHT). Although incidence of alcohol intoxication is high in these patients, the influence of alcohol intoxication on S-100B levels is unclear. Therefore, the aim of our study was to investigate serum concentrations of S-100B in intoxicated (group 1) and sober (group 2) patients after MHT in comparison with those of mild (group 3) or severely intoxicated (group 4) individuals without trauma. S-100B was significantly increased in MHT patients exhibiting posttraumatic lesions in initial cranial computed tomography scan. Alcohol intoxication did not elevate S-100B levels in group 3 or 4 subjects. Our data indicate for the first time that alcohol intoxication does not influence the diagnostic value of S-100B measurements in patients after MHT.
authors.affiliation: Chirurgische Klinik, Klinikum Innenstadt, Ludwig-Maximilians-Universität, München, Munich, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Biberthaler
authors.forename: T
authors.initials: T
authors.lastname: Mussack
authors.forename: E
authors.initials: E
authors.lastname: Wiedemann
authors.forename: T
authors.initials: T
authors.lastname: Gilg
authors.forename: M
authors.initials: M
authors.lastname: Soyka
authors.forename: G
authors.initials: G
authors.lastname: Koller
authors.forename: K J
authors.initials: KJ
authors.lastname: Pfeifer
authors.forename: U
authors.initials: U
authors.lastname: Linsenmaier
authors.forename: W
authors.initials: W
authors.lastname: Mutschler
authors.forename: C
authors.initials: C
authors.lastname: Gippner-Steppert
authors.forename: M
authors.initials: M
authors.lastname: Jochum
mesh_terms: D000428:Alcohol Drinking / Q000097:blood; D000435:Alcoholic Intoxication / Q000097:blood* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood / Q000175:diagnosis*; D006259:Craniocerebral Trauma / Q000097:blood*; D018450:Disease Progression; D000431:Ethanol / Q000097:blood*; D005260:Female; D006801:Humans; D007118:Immunoassay; D015994:Incidence; D008163:Luminescent Measurements; D008297:Male; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D000431:Ethanol