title: Pathophysiology of osteoporosis and fracture.
abstract: Bone is a vital, dynamic tissue that performs many functions, including a major role in serum homeostasis. A complex interplay of factors affects bone function and bone health. This article provides an overview of bone physiology and the pathophysiology of osteoporosis and fragility fracture. An understanding of the material presented here will provide a foundation to assess the bone health of individuals, to promote bone health, and to prevent fracture in patients of all ages.
authors.affiliation: Creighton University Schools of Nursing and Medicine, Omaha, Nebraska 68131, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Lappe
mesh_terms: D000058:Accidental Falls; D000203:Activities of Daily Living; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D015444:Exercise; D050723:Fractures, Bone / Q000209:etiology* / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D010024:Osteoporosis / Q000145:classification / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D012307:Risk Factors; D012720:Severity of Illness Index