title: Proportional assist ventilation.
abstract: Partial ventilatory support techniques are intended for patients who are unable to maintain a normal alveolar ventilation, despite normal central control for respiration. Proportional assist ventilation (PAV) is a novel mode of partial ventilatory support in which the ventilator generates an instantaneous inspiratory pressure in proportion to the instantaneous effort of the patient. In theory, PAV should normalize the neuro-ventilatory coupling by making the ventilator an extension of patient's respiratory muscles, while leaving to the patient the entire control of all aspects of breathing. PAV, however, shares a common problem with the conventional partial ventilatory support modes. In mechanically ventilated patients, the respiratory system impedance may change over time. These changes may impair the good matching between ventilator output and patient's ventilatory demand and lead to patient-ventilator asynchrony. To take full advantage of PAV, the authors believe that PAV should continuously and automatically adapt to the respiratory system passive mechanics, assessed by continuous noninvasive measurement of total elastance and resistance.
authors.affiliation: Unità Operativa di Terapia Intensiva, Azienda Ospedaliera Di Venere-Giovanni XXIII, Ospedale Di Venere, Bari, Italy. grassos@libero.it
authors.forename: S
authors.initials: S
authors.lastname: Grasso
authors.forename: V M
authors.initials: VM
authors.lastname: Ranieri
mesh_terms: D000465:Algorithms; D004417:Dyspnea / Q000628:therapy; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000628:therapy; D012121:Respiration, Artificial / Q000379:methods*; D015656:Respiratory Mechanics