Pharmacokinetics and tissue distribution of piperine in animals after i.v. bolus administration.
A reverse phase HPLC method to determine piperine, a pungent constituent of black pepper, in rabbit serum and various tissues of the rat was developed. A pharmacokinetic study was performed in rabbits and tissue distribution studies were carried out in rats. High reproducibility was achieved in quantitative analysis over the concentration range of 0.2-20 micrograms/ml serum. After bolus intravenous administration of piperine at a dose of 10 mg/kg, the serum concentration--time curve fitted the two-compartment open model. The tissue distribution pattern of piperine in rats also supports the two-compartment open model.
Sunkara
G
G
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Mada
S R
SR
Vobalaboina
V
V
D000470:Alkaloids; D000818:Animals; D019540:Area Under Curve; D052117:Benzodioxoles; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D010880:Piperidines / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D053284:Polyunsaturated Alkamides; D011817:Rabbits; D051381:Rats; D015203:Reproducibility of Results; D014018:Tissue Distribution
D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; C008922:piperine