title: Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.
abstract: Both ionotropic and metabotropic glutamate receptors (mGluRs) are involved in the behavioral effects of pyschostimulants; however, the specific contributions of individual mGluR subtypes remain unknown. Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type (WT) mice. These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction.
authors.affiliation: Department of Biology, GlaxoSmithKline Laboratories, via Fleming 4, 37100 Verona, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Chiamulera
authors.forename: M P
authors.initials: MP
authors.lastname: Epping-Jordan
authors.forename: A
authors.initials: A
authors.lastname: Zocchi
authors.forename: C
authors.initials: C
authors.lastname: Marcon
authors.forename: C
authors.initials: C
authors.lastname: Cottiny
authors.forename: S
authors.initials: S
authors.lastname: Tacconi
authors.forename: M
authors.initials: M
authors.lastname: Corsi
authors.forename: F
authors.initials: F
authors.lastname: Orzi
authors.forename: F
authors.initials: F
authors.lastname: Conquet
mesh_terms: D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout / Q000235:genetics; D009043:Motor Activity / Q000187:drug effects*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D012016:Reference Values; D012054:Reinforcement, Psychology; D012646:Self Administration
chemical_list: C578936:Grm5 protein, mouse; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D003042:Cocaine