Towards a molecular approach to gastric cancer management.
Gastric cancer is a leading cause of cancer death worldwide. Most patients with gastric cancer present with locally advanced and incurable disease, and overall survival is poor. Considerable research efforts towards the epidemiology and pathogenesis of gastric cancer have not been translated into treatment success. We discuss current concepts of the pathogenesis of gastric cancer and how recent research advances, in particular global gene expression strategies, may improve this understanding, and suggest a framework wherein these approaches may be used.
Boussioutas
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Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.
Taupin
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D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D003131:Combined Modality Therapy; D013505:Digestive System Surgical Procedures; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D013274:Stomach Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy*; D016019:Survival Analysis
D014408:Biomarkers, Tumor