title: Spindle-cell B-cell lymphoma presenting in the skin.
abstract: Lymphomas with predominant spindle-cell morphology have only been previously reported in small numbers; such lesions are potentially mistaken for sarcoma or other spindle-cell tumours. We describe a 73-year-old woman who presented with a tumour on the scalp of a few months' duration. Biopsy showed a B-cell lymphoma of follicle centre cell origin with a sarcomatoid appearance and a CD20+, CD10+, CD21+, bcl-6+ immunophenotype. This case highlights the very rare occurrence of spindle-cell B-cell lymphoma presenting in the skin. An awareness of this phenomenon is essential to avoid confusion with a variety of other cutaneous spindle-cell neoplasms and to enable a correct diagnosis to be made, thereby ensuring that appropriate treatment is initiated.
authors.affiliation: Department of Pathology, Highland Acute Hospital NHS Trust, Raigmore Hospital, Old Perth Road, Inverness IV2 3UJ, UK. John.Goodlad@raigmore.scot.nhs.uk
authors.forename: J R
authors.initials: JR
authors.lastname: Goodlad
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006258:Head and Neck Neoplasms / Q000276:immunology / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology* / Q000532:radiotherapy; D012535:Scalp / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000532:radiotherapy; D016896:Treatment Outcome
chemical_list: D000951:Antigens, Neoplasm