Evaluation of cardiac subacute toxicity of ciprofloxacin in rats using serum biochemical parameters.
Cardiac subacute toxicity induced by ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid, CAS 86393-32-0) a relatively new quinolone carboxylic acid derivative with an extensive antibacterial spectrum was investigated in healthy rats using serum biochemical parameters. Toxicological evaluation was performed in serum samples following the administration of the therapeutic dose regimens of the compound. Cardiac subacute toxicity was evaluated by measuring serum enzyme activity of creatine kinase, creatine kinase isoenzyme-MB (muscular-brain), lactate dehydrogenase and aspartate aminotransferase. The serum biochemical parameters indicated that the cardiac subactue toxicity of ciprofloxacin was: Cipro 1.2 (250 mg) = Cipro 2.4 (500 mg) < Cipro 4.3 (750 mg).
Pispirigos
K
K
Clinical Biochemistry Research Center, Patras, Greece. pispirigos@yahoo.com
Chrysanthopoulos
K
K
D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D019540:Area Under Curve; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers; D001835:Body Weight / Q000187:drug effects; D002939:Ciprofloxacin / Q000633:toxicity*; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D006331:Heart Diseases / Q000097:blood* / Q000139:chemically induced* / Q000473:pathology; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009206:Myocardium / Q000473:pathology; D051381:Rats
D000890:Anti-Infective Agents; D015415:Biomarkers; D007527:Isoenzymes; D002939:Ciprofloxacin; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form