title: Anti-inflammatory and anti-allergic actions by oral administration of a perilla leaf extract in mice.
abstract: The anti-inflammatory and anti-allergic activity of perilla leaf extract was investigated. The oral administration of perilla leaf extract to mice inhibited two types of acute inflammatory models, arachidonic acid-induced ear edema and 12-o-tetradecanoylphorbol-13-acetate-induced ear edema. Oral administration of perilla leaf extract also inhibited the contact dermatitis model, oxazolone-induced ear edema, by affecting sensitization.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ueda
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000633:toxicity; D003877:Dermatitis, Contact / Q000188:drug therapy; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010081:Oxazolone / Q000633:toxicity; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
chemical_list: D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D010081:Oxazolone; D016718:Arachidonic Acid; D013755:Tetradecanoylphorbol Acetate