Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro.
Anti-viral activities of Agaricus blazei Murill were investigated. The water extracts of the cultured mycelia and fruiting bodies were fractionated with different concentrations of ethanol. To several viruses which have cytopathic effects (CPE) on VERO cells, inhibition of these effects by the ethanol fractions was tested. Strong inhibition of CPE induced by western equine encephalitis (WEE) virus was observed in the mycelial fractions but not those of fruiting bodies.
Sorimachi
K
K
Department of Microbiology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
Ikehara
Y
Y
Maezato
G
G
Okubo
A
A
Yamazaki
S
S
Akimoto
K
K
Niwa
A
A
D000364:Agaricus / Q000737:chemistry* / Q000254:growth & development; D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004667:Encephalitis Virus, Western Equine / Q000187:drug effects* / Q000472:pathogenicity*; D014709:Vero Cells
D000998:Antiviral Agents