Adjunctive therapies in the cath lab. Combination of tirofiban and alteplase in acute myocardial infarction.
Primary angioplasty results in higher reperfusion rates than fibrinolysis in patients with acute myocardial infarction (MI). Two recent trials have shown improved rates of reperfusion when a reduced-dose thrombolytic is combined with the platelet glycoprotein IIb/IIIa receptor inhibitor abciximab. We present a case report of acute MI successfully treated with a combination of tirofiban and half-dose alteplase and eventual percutaneous coronary intervention.
Arjomand
H
H
Department of Medicine, MCP Hahnemann University, Philadelphia, Pennsylvania, USA.
Sokil
A B
AB
Arjmand
R
R
Fischer
H A
HA
Wolf
N M
NM
D000328:Adult; D000800:Angioplasty, Balloon; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D000077466:Tirofiban; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D014443:Tyrosine; D010959:Tissue Plasminogen Activator; D000077466:Tirofiban