The depressor effect of nitroglycerin is mediated by calcitonin gene-related peptide.
Previous investigations have suggested that vasodilator responses to nitroglycerin involve in stimulation of calcitonin gene-related peptide (CGRP) release. Therefore, we tested whether depressor effect of nitroglycerin is mediated by CGRP. A catheter was inserted into the left femoral artery to record blood pressure and drugs were administered through cannulae inserted into the right femoral vein. Nitroglycerin (15, 30, 60, 120 and 150 microg/kg) caused depressor effects in a dose-dependent manner. Nitroglycerin (30 or 150 microg/kg) caused a depressor effect with an increase in plasma concentrations of CGRP. The effects of nitroglycerin were significantly attenuated by methylene blue, an inhibitor of guanylate cyclase, or by pretreatment with capsaicin (50 mg x kg(-1), s.c.), which depletes neurotransmitters in sensory nerves. The present study suggests that the depressor effect of nitroglycerin is related to stimulation of CGRP release in the rat.
Zhou
Z H
ZH
Department of Pharmacology, Hunan Medical University, Changsha, PR China.
Deng
H W
HW
Li
Y J
YJ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood / Q000502:physiology*; D002211:Capsaicin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology; D005996:Nitroglycerin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014700:Verapamil / Q000494:pharmacology
D014700:Verapamil; D005996:Nitroglycerin; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin; D008751:Methylene Blue