Catalytic cyclopropanation of alkenes using diazo compounds generated in situ. A novel route to 2-arylcyclopropylamines.
[reaction: see text]. A user-friendly, one-pot process for catalytic cyclopropanation of alkenes from tosylhydrazones is described. The cyclopropanation of N-vinylphthalimide provides a new route to 2-arylcyclopropylamines, and this is exemplified in the efficient synthesis of the HIV-1 reverse transcriptase inhibitor 6.
Aggarwal
V K
VK
School of Chemistry, Bristol University, Cantock's Close, Bristol BS8 1TS, UK. v.aggrarwal@bristol.ac.uk
de Vicente
J
J
Bonnert
R V
RV