title: The filtering approach to solvent peak suppression in MRS: a critical review.
abstract: Suppressing the solvent peak is important in many applications of biomedical NMR spectroscopy in order to quantify the metabolites with a great accuracy. Among the postprocessing methods proposed in the literature, many deal with the concept of filtering. However, several proposals lack a theoretical perspective and some have not been explicitly applied to quantification problems. The present article is intended to bridge this gap: five methods are analyzed from a theoretical perspective. Subsequently the different methods are applied to the same set of data, and then the latter are quantified using the model fitting method AMARES. With our set, the scheme proposed by T. Sundin et al. (J. Magn. Reson. 139(2), 189-204 (1999)) proved to be the most reliable method.
authors.affiliation: Department of Applied Physics, Delft University of Technology, 2600 GA Delft, The Netherlands. coro@si.tn.tudelft.nl
authors.forename: A
authors.initials: A
authors.lastname: Coron
authors.forename: L
authors.initials: L
authors.lastname: Vanhamme
authors.forename: J P
authors.initials: JP
authors.lastname: Antoine
authors.forename: P
authors.initials: P
authors.lastname: Van Hecke
authors.forename: S
authors.initials: S
authors.lastname: Van Huffel
mesh_terms: D003903:Deuterium / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008433:Mathematics; D055585:Physical Phenomena; D010825:Physics
chemical_list: D003903:Deuterium