[HindIII polymorphism of lipoprotein lipase gene and risk of myocardial infarction].
The purpose of this study was to determine whether HindIII restriction polymorphism found in intron 8 of lipoprotein lipase gene is associated with the onset of myocardial infarction (MI) in Russians and Tartars living in Bashkortostan. HindIII polymorphism was investigated by the polymerase chain reaction in myocardial infarction survivors (males aged under 55 years (98 Russians and 68 Tartars) and in controls (53 Russians and 80 Tartars). The distribution of genotypes and allele frequencies in the controls were as follows: the frequencies of genotypes HindIII(-/-), HindIII(+/-), and HindIII(+/+) in Russians (3.77, 49.06, and 47.17%, respectively) did not differ from those in Tartars (7.50, 51.24, and 41.25%, respectively), while the frequency of HindIII(-) allele was 28.30% in Russians and 33.13% in Tartars. Among Tartars, the HindIII(+/+) genotype was more common in myocardial infarction survivors than in controls (OR 2.03). In the Russians this genotype was not associated with the risk of MI. The frequencies of HindIII(+/+) genotype and allele HindIII(+) were significantly higher (OR 8.96 and 6.71, respectively) and frequencies of HindIII(+/-) genotype and allele HindIII(-) were lower (OR 0.13 and 0.15) in Russian patients with repeated MI. These findings indicate that HindIII polymorphism may be a genetic risk factor for MI before 55 years of age in the Tartars and for repeated MI in Russians. This association prompts genotyping of HindIII polymorphism for predicting MI recurrence in Russian survivors after MI.
Shagisultanova
E I
EI
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences.
Mustafina
O E
OE
Tuktarova
I A
IA
Khusnutdinova
E K
EK
D044466:Asian People / Q000235:genetics; D015247:Deoxyribonuclease HindIII; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk; D012426:Russia / Q000453:epidemiology; D044465:White People / Q000235:genetics
D008071:Lipoprotein Lipase; D015247:Deoxyribonuclease HindIII
HindIII polimorfizm gena lipoproteinlipazy i risk razvitiia infarkta miokarda.