title: [Upper digestive tract findings in elderly patients with iron-deficiency anemia. A comparison between users and non-users of non-steroidal anti-inflammatory drugs].
abstract: BACKGROUND
  Iron-deficiency anemia is common in the elderly. Chronic upper gastrointestinal bleeding is its most frequent cause. The use of non-steroidal antinflammatory drugs (NSAID) is common in older people. Gastrointestinal complications of NSAID may be also more frequent among the elderly.
  
  
  OBJECTIVE
  The study was aimed to evaluate if a history of regular NSAID use in elderly patients with iron-deficiency anemia is associated to characteristic findings on esophagogastroduodenoscopy.
  
  
  METHODS
  A total of 91 patients (40% of males and 60% females) older than 65 years (mean age 77 years, range 65-90 years) entered the study. All of them had been admitted to our Hospital for study of iron-deficiency anemia. Thirty-eight patients were regular users of NSAID. Esophagogastroduodenoscopy was performed in all patients.
  
  
  RESULTS
  The prevalences of peptic ulcer, erosive gastritis/duodenitis, and esophagitis were similar in NSAID users and non-users (13 vs 11%, 18 vs 15%, and 26 vs 26%, respectively). A trend to a higher prevalence of gastric adenocarcinoma was observed the group of NSAID non-users (8% vs 23%, p = 0.05). Esophagogastroduodenoscopy was entirely normal in 39% of NSAID users and 34% of NSAID non-users.
  
  
  CONCLUSIONS
  Upper gastrointestinal lesions in elderly patients with iron-deficiency anemia are similar in NSAID users and non-users, with the exception of gastric adenocarcinoma which can be more common in NSAID non-users.
authors.affiliation: Servicios de Medicina Interna, Hospital Clínico Universitario, Santiago de Compostela.
authors.forename: C
authors.initials: C
authors.lastname: Martínez Rey
authors.forename: A
authors.initials: A
authors.lastname: González Quintela
authors.forename: M J
authors.initials: MJ
authors.lastname: Domínguez Santalla
authors.forename: J
authors.initials: J
authors.lastname: Fernández Castroagudín
authors.forename: V
authors.initials: V
authors.lastname: Lorenzo Zúñiga
mesh_terms: D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000453:epidemiology / Q000209:etiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D016145:Endoscopy, Digestive System; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000453:epidemiology* / Q000209:etiology; D006471:Gastrointestinal Hemorrhage / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
vernacular_title: Patología digestiva alta en pacientes de edad avanzada con anemia ferropénica: comparación entre usuarios y no usuarios de anti-inflamatorios no esteroideos.