title: Morphological changes of the anterior spinal artery during aortic cross-clamping and effect of prostaglandin E1 with perfusion.
abstract: This investigation was designed to evaluate the morphological changes of anterior spinal artery (ASA) and its reaction to prostaglandinE1 (PGE1) during aortic cross-clamping. ASA during 30 min cross-clamping was observed with charge-coupled device (CCD) and ASA diameter (ASAD) was measured. Group A: Infrarenal aorta was cross-clamped. Group B: Infrarenal aorta was cross-clamped and aorta above the bifurcation was snared. The aortic segment between clamp and snare was perfused with blood. Group C: PGE1 of 100 ng/kg/min was added to perfusate of Group B. The aortic segmental pressures in group B and C were about 30% of the proximal systolic arterial pressure and were significantly higher than distal pressure of group A. After cross-clamping, ASAD decreased about 80% of before cross-clamping in group A. By segmental perfusion of which pressure was about 30% of proximal systolic arterial pressure, ASAD remained almost 90% in group B. By administration of PGE1, ASAD was significantly increased in group C. The changes of ASAD were significantly different between group A and C, and between group B and C.
authors.affiliation: First Department of Surgery, Gifu University School of Medicine, Japan. fukumoto@abox8.go-net.ne.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Fukumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: H
authors.initials: H
authors.lastname: Iwata
authors.forename: K
authors.initials: K
authors.lastname: Murase
authors.forename: T
authors.initials: T
authors.lastname: Miyauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Umeda
authors.forename: H
authors.initials: H
authors.lastname: Hirose
mesh_terms: D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001158:Arteries / Q000033:anatomy & histology* / Q000187:drug effects / Q000473:pathology; D008297:Male; D010477:Perfusion; D011817:Rabbits; D013131:Spine / Q000098:blood supply*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil