Macrophage migration inhibitory factor in hepatocellular carcinoma and liver cirrhosis; relevance to pathogenesis.
The levels of macrophage migration inhibitory factor (MIF), a proinflammatory and carcinogenic cytokine, were significantly higher in the sera from patients with hepatocellular carcinoma (HCC; 25.6+/-15.3 ng/ml, n=55) and liver cirrhosis (LC; 18.9+/-10.7 ng/ml, n=26) compared with sera from patients with gastrointestinal cancer (6.8+/-7.5 ng/ml, n=29) and normal controls (5.6+/-1.2 ng/ml, n=45; P<0.01). Hepatocytes from patients with LC and HCC, but not from chronic hepatitis, expressed very high levels of MIF. A possible association between overexpression of MIF and hepatocarcinogenesis is suggested.
Akbar
S M
SM
Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-Cho, Ehime, Japan.
Abe
M
M
Murakami
H
H
Tanimoto
K
K
Kumagi
T
T
Yamashita
Y
Y
Michitaka
K
K
Horiike
N
N
Onji
M
M
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000209:etiology / Q000473:pathology; D002478:Cells, Cultured; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood; D006521:Hepatitis, Chronic / Q000097:blood; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology; D008113:Liver Neoplasms / Q000097:blood* / Q000209:etiology / Q000473:pathology; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis / Q000097:blood*; D008297:Male; D008875:Middle Aged
D008263:Macrophage Migration-Inhibitory Factors