title: Evaluation of dosed red blood cell units collected with Gambro BCT--TRIMA.
abstract: The increasing need of collecting high quality blood components and of improving the overall productivity of a blood centre requires the utilisation of a new innovative process that combines high speed collection with an automated process and blood component tailoring to fit individual patient requirements. We collected dosed Red Blood Cell (dRBC) units on 64 donors, eligible as regular donors on the Gambro BCT TRIMA using the dRBC collection protocol. The collection target was set to 180 ml packed Red Blood Cells (pRBCs) in 225 ml total collection volume (n = 7), or 300 ml pRBCs in 375 ml total collection volume (n = 33) or 360 ml in 450 ml (n = 24), depending on donor's hematological profile and blood volemia. Saline was infused as the replacement fluid at a 120%) collection:infusion ratio. Donor per cent hematocrit was (mean +/- S.D.) 43.7 +/- 4.0% and TBV = 4.99 +/- 0.69 1. The procedures yielded 100 +/- 6% of predicted yield, with a hematocrit of 78.2 +/- 6.6% in 29 +/- 3 min. Hb content was 99.9 +/- 21.8 in all procedures, or 61.5-94.4-118.6 g in the three groups, respectively. After the addition of the SAG-M storage solution, the hematocrit was 56.3 +/- 6.2%. No adverse reactions have been reported by the donors and all pPRBC units were transfused to patients without any transfusion reaction being reported by clinicians. The dRBC protocol is well tolerated by donors without any side effects, other than normal effects of regular blood donation. Higher pRBC productivity can be reached with a safe and automated process in conjunction with a high and consistent product quality easily matching the donor collection criteria and pRBC unit standards. Tailoring of pRBC units can result in an improved patient transfusion support.
authors.affiliation: Immunohematology Service, San Martino University Hospital, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Valbonesi
authors.forename: R
authors.initials: R
authors.lastname: Bruni
authors.forename: G
authors.initials: G
authors.lastname: Florio
authors.forename: A
authors.initials: A
authors.lastname: Zanella
authors.forename: G
authors.initials: G
authors.lastname: van Waeg
mesh_terms: D001781:Blood Component Removal / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D001782:Blood Donors; D001800:Blood Specimen Collection / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D017707:Erythrocyte Transfusion / Q000191:economics / Q000379:methods* / Q000592:standards; D006454:Hemoglobins / Q000627:therapeutic use; D006801:Humans
chemical_list: D006454:Hemoglobins