title: Failure of one-day praziquantel treatment in patients with multiple neurocysticercosis lesions.
abstract: A recently described one-day regimen of praziquantel (PZQ) therapy for neurocysticercosis (NCC), three doses of 25 mg/k given at 2 h intervals, was applied in eight patients with viable NCC cysts without any evidence of inflammation. Resolution of lesions in computed tomography (CT) was observed in all five patients with a single cyst, whereas all cysts survived in three patients with multiple brain parasites. One-day praziquantel is a good regimen for patients with a single viable brain cysticercus but is poorly effective for multiple cysts.
authors.affiliation: Department of Transmissible Diseases, Instituto Nacional de Ciencias Neurológicas, Jr. Ancash 1271, Barrios Altos, 1, Lima, Peru.
authors.forename: E J
authors.initials: EJ
authors.lastname: Pretell
authors.forename: H H
authors.initials: HH
authors.lastname: García
authors.forename: R H
authors.initials: RH
authors.lastname: Gilman
authors.forename: H
authors.initials: H
authors.lastname: Saavedra
authors.forename: M
authors.initials: M
authors.lastname: Martinez
mesh_terms: D000328:Adult; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003552:Cysticercus / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020019:Neurocysticercosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011223:Praziquantel / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D011223:Praziquantel