Regulation of gene expression by nitric oxide.
Nitric oxide (NO) modulates transcription factors that bind specific cis-regulatory DNA responsible for coordinating the spatial and temporal patterns of gene expression that are initiated by a changing microenvironment. In this way NO helps to orchestrate gene transcription and forms the basis of functional cell responses to accommodate metabolic requirements and to coordinate endogenous defense mechanisms against a variety of stress and disease conditions. There is marked overlap between the signalling pathways triggered by NO, superoxide, and hypoxia. Understanding the redox-based regulation of signal transduction and gene expression will provide insights into how cell activities are constantly coordinated and how promising new therapies may be developed.
Pfeilschifter
J
J
Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany. Pfeilschifter@em.uni-frankfurt.de
Eberhardt
W
W
Beck
K F
KF
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics*
D009569:Nitric Oxide