A new view of the spindle checkpoint.
Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.
Hoyt
M A
MA
Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA. hoyt@jhu.edu
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002352:Carrier Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D018386:Kinetochores / Q000378:metabolism; D008025:Ligases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020409:Molecular Motor Proteins / Q000378:metabolism; D009687:Nuclear Proteins; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D015398:Signal Transduction / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology*; D043743:Ubiquitin-Protein Ligase Complexes; D044767:Ubiquitin-Protein Ligases; D015003:Yeasts / Q000502:physiology*
D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D005656:Fungal Proteins; D020409:Molecular Motor Proteins; D009687:Nuclear Proteins; C068688:centromere protein E; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044767:Ubiquitin-Protein Ligases; D011494:Protein Kinases; C090464:Bub1 spindle checkpoint protein; D017346:Protein Serine-Threonine Kinases; D008025:Ligases