title: Early introduction of cereals into children's diets as a risk-factor for grass pollen asthma.
abstract: BACKGROUND
  The prevalence of asthma has increased from the 1950s to the 1990s. The relationship between diet and asthma is an area of controversy that has never been fully evaluated. Attempts at dietary prevention of asthma have produced conflicting results. We have recently identified allergens from cereals that show cross-reactivity with proteins in grass pollen. An early intake of cereals in the diet during early life might cause IgE sensitization to cereals. It is not known whether such sensitization predisposes the development of allergy to pollen.
  
  
  METHODS
  To test this hypothesis, a cross-sectional study and an observational case-control analysis of reviewed data were carried out on 16381 patients who had been admitted to our Allergy Unit between 1989 and 1999. All the patients underwent allergy tests to identify asthma risk-factors. All information in our data base was analysed using the SPSS computer system.
  
  
  RESULTS
  There has been an increase of 7.8% in incidences of allergic asthma and a 7.3% increase in asthma due to grass pollen in the last decade. Grass-pollen asthma was associated with sensitization to cereals. The early introduction of cereals in the diet of children was found to be a risk factor for grass-pollen asthma (OR = 5.95; 95% CI 3.89-9.10).
  
  
  CONCLUSIONS
  These findings document the progression of allergic asthma during a decade in a large sample of people who were influenced by similar environmental conditions and studied with the same diagnostic methods. This study represents the largest database of patients in which a common food is shown to be a risk factor for asthma.
authors.affiliation: Allergy Section, Rio Hortega Hospital, Valladolid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Armentia
authors.forename: C
authors.initials: C
authors.lastname: Bañuelos
authors.forename: M L
authors.initials: ML
authors.lastname: Arranz
authors.forename: V
authors.initials: V
authors.lastname: Del Villar
authors.forename: J M
authors.initials: JM
authors.lastname: Martín-Santos
authors.forename: F J
authors.initials: FJ
authors.lastname: Gil
authors.forename: J M
authors.initials: JM
authors.lastname: Vega
authors.forename: A
authors.initials: A
authors.lastname: Callejo
authors.forename: C
authors.initials: C
authors.lastname: Paredes
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D001249:Asthma / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D004032:Diet / Q000009:adverse effects; D002523:Edible Grain / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D006109:Poaceae / Q000276:immunology*; D011058:Pollen / Q000276:immunology*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D000485:Allergens