The concentrations of osteocalcin and degradation products of type I collagen in pregnant women with pre-eclampsia.
OBJECTIVE
To investigate the concentrations of osteocalcin and collagen type I C-terminal telopeptides in pregnant women with pre-eclampsia.


METHODS
26 patients with severe pre-eclampsia and 24 healthy pregnant women were included in the study. Serum concentrations of osteocalcin and C-telopeptides--degradation products of type I collagen were determined using the ELISA method. Statistical analysis was performed using Mann-Whitney U-test.


RESULTS
In pre-eclamptic patients, the concentrations of osteocalcin and degradation products of collagen type I were significantly higher (P<0.005) when compared to healthy pregnant women.


CONCLUSIONS
These results could suggest that there are alterations in bone metabolism in pregnant women with pre-eclampsia.
Gorzelak
M
M
Department of Orthopedics, University School of Medicine, Jaczewskigo 8, 20-950, Lublin, Poland.
Darmochwal-Kolarz
D
D
Jablonski
M
M
Rolinski
J
J
Leszczynska-Gorzelak
B
B
Modrzewski
K
K
Oleszczuk
J
J
D000328:Adult; D001842:Bone and Bones / Q000378:metabolism; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015675:Osteocalcin / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012016:Reference Values
D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003094:Collagen