title: Biological evaluation of 2-fluoro-2-[123I]iodo-mannose (FIM): biological evaluation of FIM.
abstract: This paper describes the biodistribution of a radio-iodinated analog of fluorodeoxyglucose (FDG). 123I-2-fluoro-2-iodo-mannose (FIM) was investigated as a potential single photon emission tomography (SPECT) imaging agent. We also compare the results with the observed distribution of the classical PET agent 18F-FDG and newly developed 18F-difluorodeoxyglucose (DFDG). Following radioiodination, the final product was stable in-vitro for 24 hrs. Mice showed a rapid blood clearance and deiodination of the 123I-FIM reflected by high stomach and thyroid uptake. Comparison with 18F-FDG and 18F-DFDG revealed a large discrepancy between the 18F labeled sugars and the 123I-FIM biological distribution. The iodinated product was not found to be a metabolic marker for in-vivo studies.
authors.affiliation: Medical imaging, Dalhousie University, Halifax, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Matte
authors.forename: M
authors.initials: M
authors.lastname: Adam
authors.forename: D
authors.initials: D
authors.lastname: Lyster
mesh_terms: D000818:Animals; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes; D008358:Mannose / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D051379:Mice; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: C440010:2-fluoro-2-iodomannose; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008358:Mannose