title: Cytotoxic diacetylenes from the stony coral Montipora species.
abstract: Ten new (1, 4-6, 9-14) and four known (2, 3, 7, 8) diacetylenes have been isolated from a brine shrimp active fraction of the methanolic extract of the stony coral Montipora sp. The structures were determined by combined spectroscopic methods. The compounds exhibited significant cytotoxicity against a small panel of human solid tumor cell lines. Montiporyne A (15), a previously reported congener, was also found to induce apoptosis in human colon tumor cell.
authors.affiliation: College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
authors.forename: N
authors.initials: N
authors.lastname: Alam
authors.forename: B H
authors.initials: BH
authors.lastname: Bae
authors.forename: J
authors.initials: J
authors.lastname: Hong
authors.forename: C O
authors.initials: CO
authors.lastname: Lee
authors.forename: K S
authors.initials: KS
authors.lastname: Im
authors.forename: J H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000480:Alkynes; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003063:Cnidaria / Q000737:chemistry*; D003110:Colonic Neoplasms; D006801:Humans; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D014961:X-Ray Diffraction
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; C436665:montiporyne A; D000114:Acetylene