Anticancer properties for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007)/3,7-diaminophenothiazin-5-ium double salts.
4,4'-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) formed stable double salts with phenothiazin-5-ium salts (2a-d), which have improved in vitro anticancer activities, as compared to A-007 alone. The stable salt between methylene blue (2a) and A-007 allowed the latter to diffuse into the dermis layers of skin. It is anticipated that these new salts will allow A-007 to penetrate into the deep lymphatic/vascular channels of the dermis, which contain metastatic cancer cells, and improve in vivo anticancer activities.
Morgan
L R
LR
DEKK-TEC, Inc., New Orleans LA 70119, USA. lrm1579@aol.com
Rodgers
A H
AH
LeBlanc
B W
BW
Boué
S M
SM
Yang
Y
Y
Jursic
B S
BS
Cole
R B
RB
D000279:Administration, Cutaneous; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D004058:Diffusion; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010640:Phenothiazines / Q000737:chemistry*; D051381:Rats; D014407:Tumor Cells, Cultured
C097674:4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone; D000970:Antineoplastic Agents; D006835:Hydrazones; D010636:Phenols; D010640:Phenothiazines; C435667:3,7-diaminophenothiazin-5-ium