Crow-Fukase syndrome with ischemic cardiomyopathy.
A 31-year-old man was admitted to our hospital for further evaluation of heart failure symptoms. Crow-Fukase syndrome was diagnosed on the basis of findings of polyneuropathy, hepatomegaly, monoclonal hypergammaglobulinemia, and hypertrichosis. Dipyridamole-stress thallium-201 perfusion imaging, contrast left ventriculography, and coronary angiography revealed a markedly dilated and dysfunctioning left ventricle, extensive reversible ischemia with fixed defect, and multiple coronary lesions. Histopathology of myocardial biopsy specimens demonstrated ischemia-induced myocardial necrosis. These findings suggested that ischemic cardiomyopathy, probably due to inflammatory reactions of coronary arteries in Crow-Fukase syndrome, was responsible for the heart failure symptoms and left ventricular dysfunction in this patient.
Ichikawa
Y
Y
Second Department of Internal Medicine, Sapporo Medical University School of Medicine.
Nakata
T
T
Ohhata
J
J
Wakabayashi
T
T
Sasao
H
H
Tsuchihashi
K
K
Shimamoto
K
K
Chiba
S
S
Matsumoto
H
H
D000328:Adult; D017023:Coronary Angiography; D004176:Dipyridamole; D004562:Electrocardiography; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016878:POEMS Syndrome / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011877:Radionuclide Imaging; D013793:Thallium; D014665:Vasodilator Agents; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology
D014665:Vasodilator Agents; C027549:thallium chloride; D004176:Dipyridamole; D013793:Thallium