Vaccination against gastrointestinal nematode parasites of ruminants using gut-expressed antigens.
To date, proteins isolated from the surface of the gut of gastrointestinal nematodes, particularly Haemonchus contortus, have generally proved to be useful protective antigens and several are being progressed towards recombinant protein-based vaccines. This paper describes the properties of some of the most promising antigens and summarises their performance in laboratory and field based trials. The antigens described include contortin, H11, H-gal-GP, GPI and cysteine proteinases. In addition, the discussion addresses the utility of selected antigens to protect against co-infecting nematode species such as Teladorsagia circumcincta and against related nematode infections such as Ostertagia ostertagi in cattle.
Knox
D P
DP
Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, Scotland EH26 0PZ, UK. knoxd@mri.sari.ac.uk
Smith
W D
WD
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D004064:Digestive System / Q000469:parasitology; D006188:Haemonchiasis / Q000517:prevention & control / Q000662:veterinary*; D006189:Haemonchus / Q000276:immunology*; D007411:Intestinal Diseases, Parasitic / Q000517:prevention & control / Q000662:veterinary*; D009348:Nematoda; D009349:Nematode Infections / Q000517:prevention & control / Q000662:veterinary; D012418:Ruminants / Q000469:parasitology*; D014611:Vaccination / Q000662:veterinary; D014612:Vaccines; D014614:Vaccines, Synthetic
D000947:Antigens, Helminth; D014612:Vaccines; D014614:Vaccines, Synthetic