Analysis of 825C/T polymorphism of G proteinbeta3 subunit in obese/diabetic Japanese.
The GNB3 825C/T polymorphism, which is common worldwide, is associated with enhanced G-protein activation. The frequency of 825-T allele was increased with body mass index (BMI) and finally had a high frequency in relatively mild obese (BMI >27 kg/m(2)) subjects in some populations. In the present study, we investigated 208 severely obese [BMI >or=30 kg/m(2) (97th percentile)] Japanese subjects including 146 probands with diabetes. No increase in the 825-T allele frequency was observed in the 208 severely obese and even in a subgroup of the 55 most obese [BMI >or=35 kg/m(2) (99.7th percentile)] subjects compared with that in 150 controls (BMI <25 kg/m(2)) (0.48 and 0.48 vs 0.51, respectively). Also, the frequency was not increased in the 146 obese subjects with diabetes (0.48). We concluded that the 825-T allele is not associated with obesity or diabetes associated with obesity at least in the Japanese population.
Ohshiro
Y
Y
First Department of Medicine, Wakayama University of Medical Science, 811-1 Kimi-idera, Wakayama 641-8509, Japan.
Ueda
K
K
Wakasaki
H
H
Takasu
N
N
Nanjo
K
K
D015992:Body Mass Index; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D009765:Obesity / Q000150:complications / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide
D020962:Heterotrimeric GTP-Binding Proteins