title: Aflatoxins and fumonisins in corn from the high-incidence area for human hepatocellular carcinoma in Guangxi, China.
abstract: A comparative study on the natural occurrence of aflatoxins and Fusarium toxins was conducted with corn samples from high- and low-incidence areas for human primary hepatocellular carcinoma (PHC) in Guangxi, China. In samples from the high-risk area, aflatoxin B(1) was the predominant toxin detected in terms of quantity and frequency, with its concentration ranging between 9 and 2496 microg/kg and an 85% incidence of contamination. Among the samples, 13 (76%) exceeded the Chinese regulation of 20 microg/kg for aflatoxin B(1) in corn and corn-based products intended for human consumption. Significant differences in aflatoxin B(1), B(2), and G(1) and total aflatoxin concentrations in corn between the areas were found (P < 0.05). The average daily intake of aflatoxin B(1) from corn in the high-risk area was 184.1 microg, and the probable daily intake is estimated to be 3.68 microg/kg of body weight/day, 3.20 times the TD(50) in rats. Corn samples from both areas were simultaneously contaminated with fumonisins B(1), B(2), and B(3). Aflatoxin B(1) may play an important role in the development of PHC in Guangxi.
authors.affiliation: Department of Biochemistry and Food Science, Faculty of Agriculture, Kagawa University, Miki, Kagawa 761-0795, Japan.
authors.forename: F Q
authors.initials: FQ
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Yoshizawa
authors.forename: O
authors.initials: O
authors.lastname: Kawamura
authors.forename: X Y
authors.initials: XY
authors.lastname: Luo
authors.forename: Y W
authors.initials: YW
authors.lastname: Li
mesh_terms: D016604:Aflatoxin B1 / Q000633:toxicity; D000348:Aflatoxins / Q000633:toxicity*; D002264:Carboxylic Acids; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000209:etiology; D002681:China / Q000453:epidemiology; D005506:Food Contamination; D037341:Fumonisins; D005670:Fusarium; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000209:etiology; D009183:Mycotoxins / Q000633:toxicity*; D012449:Safety; D003313:Zea mays / Q000737:chemistry / Q000382:microbiology*
chemical_list: D000348:Aflatoxins; D002264:Carboxylic Acids; D037341:Fumonisins; D009183:Mycotoxins; C056934:fumonisin B2; C056933:fumonisin B1; D016604:Aflatoxin B1