title: Increased tissue concentrations of arachidonic acid in umbilical artery and placenta in fetal growth retardation.
abstract: OBJECTIVE
  To compare the fatty acid phospholipid composition of the umbilical artery and the placenta in cases of fetal growth retardation (FGR) and of normal growth, as well as in symmetric and asymmetric FGR.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Thirty-nine FGR cases (12 asymmetric, 27 symmetric) and 78 cases with normal growth.
  
  
  METHODS
  Thin layer gas-liquid capillary chromatography of phospholipid fatty acids in umbilical artery and placental cotyledons. Newborns were classified as FGR if their weight was under the 10th percentile for our center. FGR was defined as symmetric if the ponderal index was >2.32, and as asymmetric if it was <2.32.
  
  
  RESULTS
  In FGR, arachidonic acid was significantly increased both in placenta (24.05%+/-2.78 vs 22.46%+/-2.93) and in umbilical artery (16.76%+/-2.40 vs 15.58%+/-3.67). Indeed this increase was significantly higher in asymmetric than in symmetric FGR (25.70+/-2.32 vs 23.32+/-2.68 in placenta and 18.06+/-1.46 vs 16.14 +/-2.53 in umbilical artery). On the other hand, in the placenta there were a number of differences in the metabolic ratios analyzed when comparing symmetric and asymmetric FGR, indicating a lower DHA availability and a higher n-6 fatty acid elongation and desaturation in asymmetric FGR.
  
  
  CONCLUSIONS
  FGR is characterized by an increase in arachidonic acid both in the placenta and umbilical artery phospolipids, probably reflecting a different mobilization from tissue stores. It is speculated that the different arterial composition could be partially responsible for the increased cardiovascular risk of FGR in adulthood. On the other hand the metabolic status of the placenta concerning polyunsaturated fatty acids was very different in symmetric and asymmetric FGR, suggesting a different pathogenesis.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital from Cruces, País Vasco University, Baracaldo, Vizcaya, Spain. rmatorras@hcru.osakidetza.net
authors.forename: R
authors.initials: R
authors.lastname: Matorras
authors.forename: A
authors.initials: A
authors.lastname: López De Larrucea
authors.forename: P
authors.initials: P
authors.lastname: Sanjurjo
authors.forename: J
authors.initials: J
authors.lastname: Ignacio Ruiz
authors.forename: Y
authors.initials: Y
authors.lastname: Echevarría
authors.forename: A
authors.initials: A
authors.lastname: Nieto
authors.forename: L
authors.initials: L
authors.lastname: Perteagudo
authors.forename: J L
authors.initials: JL
authors.lastname: Aldamiz-Echevarria
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D010743:Phospholipids / Q000032:analysis; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D014018:Tissue Distribution; D014469:Umbilical Arteries / Q000737:chemistry*
chemical_list: D010743:Phospholipids; D016718:Arachidonic Acid