Acquisition of virulence-associated factors by the enteric pathogens Escherichia coli and Salmonella enterica.
In this review we summarize recent genomic studies that shed light on the mechanism through which pathogenic Escherichia coli and Salmonella enterica have evolved. We show how acquisition of DNA at specific sites on the chromosome has contributed to increased genetic variation and virulence of these two genera of the Enterobacteriaceae.
Wain
J
J
Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology and Medicine, South Kensington, London W7 2AZ, UK. jwain@ic.ac.uk
House
D
D
Pickard
D
D
Dougan
G
G
Frankel
G
G
D004926:Escherichia coli / Q000472:pathogenicity* / Q000502:physiology*; D022761:Gene Transfer, Horizontal; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D019779:Salmonella enterica / Q000472:pathogenicity* / Q000502:physiology*; D014774:Virulence / Q000502:physiology*