title: Severe preeclampsia in antithrombin III deficiency with no history of venous thromboembolism.
abstract: Complications of pregnancy, such as preeclampsia, placental abruption, fetal growth retardation, still-birth and fetal death are associated with an increased frequency of pro-thrombotic abnormalities. We describe a case of severe preeclampsia and multiple placental infarctions in a 28-year-old woman at 31 weeks' gestation. Despite a negative personal history for venous thromboembolism, coagulation screening for thrombophilia detected an isolated antithrombin III deficiency. In view of the high prevalence of pro-thrombotic complications, laboratory screening for thrombophilia would be advantageous in women with complicated pregnancies, to ensure adequate management in high-risk situations, as suggested by larger-scale clinical investigations.
authors.affiliation: Division of Nephrology, Verona Hospital, Italy. lgammaro@interfree.it
authors.forename: L
authors.initials: L
authors.lastname: Gammaro
authors.forename: G
authors.initials: G
authors.lastname: Lippi
authors.forename: E
authors.initials: E
authors.lastname: Bottini
authors.forename: G
authors.initials: G
authors.lastname: Valenti
authors.forename: F
authors.initials: F
authors.lastname: Manzato
authors.forename: N
authors.initials: N
authors.lastname: Tessitore
authors.forename: G
authors.initials: G
authors.lastname: Maschio
mesh_terms: D000328:Adult; D020152:Antithrombin III Deficiency / Q000150:complications*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D012720:Severity of Illness Index