Paediatric transfusion.
Paediatric transfusion encompasses a wide range of clinical circumstances including the consideration of maternal antibodies, the changing nature of the transfusion recipient with respect to growth and development, and the management of inherited conditions which if optimally treated in early life may have problems which are delayed or less severe in adult life. Whilst the transfusion of adults and children has much in common, a child cannot be considered as a scaled down adult; there are many important differences. Developmental changes are most marked in the neonate and, together with the fact that their antibodies are maternally derived, this population provide some of the most striking challenges. The increased use of intra uterine transfusion adds an extra dimension here. A particular paediatric concern is the long-term consequences of transfusion. It is to be hoped that paediatric transfusion recipients will live long enough that any potential problems will manifest themselves, thus the aim must be to minimize transfusion risks.
Simpson
J
J
Yorkshire Regional Centre for Paediatric Oncology & Haematology, St James's University Hospital, Leeds, UK.
Kinsey
S
S
D001773:Blood Cells / Q000382:microbiology / Q000637:transplantation; D001803:Blood Transfusion / Q000592:standards*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007223:Infant; D007231:Infant, Newborn; D012203:Rh Isoimmunization / Q000209:etiology / Q000517:prevention & control; D012449:Safety; D013242:Sterilization; D065227:Transfusion Reaction