Finding drug targets in microbial genomes.
In this era of genomic science, knowledge about biological function is integrated increasingly with DNA sequence data. One area that has been significantly impacted by this accumulation of information is the discovery of drugs to treat microbial infections. Genome sequencing and bioinformatics is driving the discovery and development of novel classes of broad-spectrum antimicrobial compounds, and could enable medical science to keep pace with the increasing resistance of bacteria, fungi and parasites to current antimicrobials. This review discusses the use of genomic information in the rapid identification of target genes for antimicrobial drug discovery.
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T D.
TD
Microbial Genomics Group, The Institute for Genomic Research, 9712 Medical Center 20851, Tel.: +1 301 838 3554, fax: +1 301 838 0208, Drive Rockville, MD, USA
Gill
S R.
SR
Tettelin
H
H
Dougherty
B A.
BA