title: Regional cerebral blood flow correlated with flashback intensity in patients with posttraumatic stress disorder.
abstract: BACKGROUND
  Nuclear imaging studies have examined cerebral blood flow (rCBF) in subjects with posttraumatic stress disorder (PTSD) using symptom evocation paradigms. To date, no such studies have investigated rCBF as related to subjects' reports of flashback intensity.
  
  
  METHODS
  Subjects with varying traumatic histories and longstanding PTSD were studied using [15O]-H2O positron emission tomography with an auditory script of their traumatic event. Eight subjects had three resting scans followed by their script and additional scans. Heart rate responses as well as the presence of flashbacks and their intensity were recorded. rCBF was correlated with flashback intensity in each subject's scan. Combined analysis of all subjects' data yielded common regions related to the flashback experience.
  
  
  RESULTS
  rCBF correlated directly with flashback intensity in the brainstem, lingula, bilateral insula, right putamen and left hippocampal and perihippocampal, somatosensory and cerebellar regions. Inverse correlations with rCBF were found in bilateral dorsolateral prefrontal, right fusiform and right medial temporal cortices.
  
  
  CONCLUSIONS
  This study correlated flashback intensity and rCBF in a group of patients with chronic PTSD suggesting involvement of brainstem, and areas associated with motor control, complex visual/spatial cues and memory.
authors.affiliation: Uniformed Services University of the Health Sciences, Maryland, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Osuch
authors.forename: B
authors.initials: B
authors.lastname: Benson
authors.forename: M
authors.initials: M
authors.lastname: Geraci
authors.forename: D
authors.initials: D
authors.lastname: Podell
authors.forename: P
authors.initials: P
authors.lastname: Herscovitch
authors.forename: U D
authors.initials: UD
authors.lastname: McCann
authors.forename: R M
authors.initials: RM
authors.lastname: Post
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D002908:Chronic Disease; D003463:Cues; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013028:Space Perception / Q000502:physiology; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis* / Q000503:physiopathology*; D014055:Tomography, Emission-Computed; D014796:Visual Perception / Q000502:physiology