[Effect of sumatriptan on cerebral blood flow during migraine headache: measurement by sequential SPECT used 99mTc-ECD background subtraction method].
The present study was designed to examine the effect of sumatriptan on regional cerebral blood flow (CBF) during migraine headache. Nine cases were examined by 99mTc-ECD background subtraction method for the absolute value measurement of regional CBF before and after sumatriptan injection. rCBF except for occipital and perioccipital lobes, were increased 10-20% during migraine headache and significant decreases were observed by sumatriptan injection. Two cases of nine had transiently increased systemic blood pressure and cardiac pulse rate, however, all cases improved migraine headache after injection of sumatriptan.
Ueda
T
T
Department of Neurosurgery, Miyazaki Social Insurance Hospital, 1-2-1, Ohtsubo, Miyazaki 880-8585, Japan.
Torihara
Y
Y
Tsuneyoshi
N
N
Ikeda
Y
Y
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003545:Cysteine / Q000031:analogs & derivatives; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D017366:Serotonin Receptor Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D018170:Sumatriptan / Q000494:pharmacology* / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D017366:Serotonin Receptor Agonists; D018170:Sumatriptan; C059659:technetium Tc 99m bicisate; D003545:Cysteine