[Effects of clinical indices and anti-angina therapy on the quality of life in patients with stable angina pectoris].
OBJECTIVE
To determine effects of basic clinical indices and various antianginal drugs on quality of life (QL) assessed with general and special questionnaire before and after selection of antianginal therapy in patients with stable angina pectoris.


METHODS
The study enrolled 89 patients with stable angina (functional class II-IV). They were examined before and after decision on adequate therapy. QL was assessed with questionnaires Disease Impact Profile and Seatle Angina Questionnaire (SAQ). Factors essential for QL were determined with factor analysis and multiple regression methods. QL correlation with exercise tolerance was examined.


RESULTS
SAQ has identified a positive correlation of some parts and total QL with exercise tolerance (p < 0.05). Treatment satisfaction correlated negatively with intensity of threshold load (p < 0.05). Factors affecting QL differed in patients with selected and non-selected therapy. QL was affected by anginal severity and complications, concomitant diseases with chest pain, harmful habits. Intake of non-selected drugs (beta-adrenoblockers, aspirin, ACE inhibitors, saluretics, benzodiazepins) may deteriorate QL.


CONCLUSIONS
It is impossible to describe QL with clinical characteristics alone. This is an independent index which requires a special estimation.
Syrkin
A L
AL
Pechorina
E A
EA
Drinitsina
S V
SV
D000328:Adult; D000787:Angina Pectoris / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
Vliianie klinicheskikh pokazateleĭ i antianginal'noĭ terapii na kachestvo zhizni bol'nykh stabil'noĭ stenokardieĭ.