IL-6 gene amplification and expression in human glioblastomas.
The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding suggests that the amplification of IL-6 gene may be a common feature in glioblastomas and may contribute to the IL-6 over-expression.
Tchirkov
A
A
Centre Jean Perrin, 58 rue Montalembert, 63011 Clermont-Ferrand, France.
Rolhion
C
C
Bertrand
S
S
Doré
J F
JF
Dubost
J J
JJ
Verrelle
P
P
D017931:DNA Primers; D004273:DNA, Neoplasm / Q000032:analysis; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D016133:Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
D017931:DNA Primers; D004273:DNA, Neoplasm; D015850:Interleukin-6