title: [Role of the hemostatic system in the progression of acute glomerulonephritis].
abstract: OBJECTIVE
  To study basic parameters of hemostasis in the course of acute poststreptococcal glomerulonephritis (APSGN).
  
  
  METHODS
  Platelets number and aggregation 4-platelet factor, Willebrand's factor, activated partial thromboplatelet time, antithrombin III, fibrin-monomeric complexes and products of degradation fibrinogen/fibrin were studied in 127 APSGN patients. Autocoagulation, prothrombin and thrombin tests were made.
  
  
  RESULTS
  Progredient thrombinemia, stable elevation of Willebrand's factor, high aggregation activity of platelets and content of their degradation products evidence for intrarenal microthrombogenesis in APSGN, confirms direct involvement of platelet hemostasis in long-term inflammation in this disease.
  
  
  CONCLUSIONS
  Mechanisms of APSGN development operate also through changes in hemostatic system.
authors.forename: E A
authors.initials: EA
authors.lastname: Movchan
authors.forename: N L
authors.initials: NL
authors.lastname: Tov
authors.forename: S A
authors.initials: SA
authors.lastname: Loskutova
authors.forename: A V
authors.initials: AV
authors.lastname: Chuprova
mesh_terms: D000208:Acute Disease; D000328:Adult; D001780:Blood Coagulation Tests; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000097:blood* / Q000209:etiology; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010976:Platelet Count; D013290:Streptococcal Infections / Q000150:complications
vernacular_title: Rol' sistemy gemostaza v progressirovanii ostrogo glomerulonefrita.