title: Hypoglycemia associated with the production of insulin-like growth factor II in adrenocortical carcinoma.
abstract: A 78-year-old woman was hospitalized for congestive heart failure and repeated hypoglycemic attacks. The laboratory data showed a serum insulin level within the normal range and an increased level of serum insulin-like growth factor (IGF) II. Abdominal ultrasonogram and computed tomography scan revealed a huge mass lying above the left kidney. She was diagnosed as having an adrenocortical carcinoma. After the removal of the tumor, the plasma glucose level and the serum level of IGF-II were normalized. The tumor cells stained positively for IGF-II immunohistochemically. These findings suggested that the hypoglycemia was due to IGF-II produced by the adrenocortical carcinoma.
authors.affiliation: Department of Cardiology, Omori Red Cross Hospital, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Eguchi
authors.forename: A
authors.initials: A
authors.lastname: Tokuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: G
authors.initials: G
authors.lastname: Kawahara
authors.forename: M
authors.initials: M
authors.lastname: Aiba
authors.forename: Y
authors.initials: Y
authors.lastname: Inishi
authors.forename: H
authors.initials: H
authors.lastname: Minowa
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000032:analysis / Q000378:metabolism*; D011863:Radioimmunoassay
chemical_list: D007335:Insulin-Like Growth Factor II