Regulation of hematopoiesis by chemokine family members.
Chemokines, originally designated as chemoattractant cytokines, comprise a large family of molecules that have been implicated in a number of different functions mediated through chemokine receptors. Among these functions are regulatory roles in hematopoiesis that encompass effects on the proliferation, survival, and homing/migration of myeloid progenitor cells. This article reviews the field of chemokine regulation of hematopoiesis at the level of myeloid progenitor cells.
Broxmeyer
H E
HE
Department of Microbiology and Immunology, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis 46202-5254, USA. hbroxmey@iupui.edu
D000818:Animals; D002455:Cell Division; D002470:Cell Survival; D054407:Chemokine CCL4; D054377:Chemokine CXCL12; D018925:Chemokines / Q000502:physiology*; D019743:Chemokines, CXC / Q000502:physiology; D002633:Chemotaxis; D005544:Forecasting; D019204:GTP-Binding Proteins / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D008024:Ligands; D019402:Macrophage Inflammatory Proteins / Q000502:physiology; D022423:Myeloid Cells / Q000166:cytology; D054400:Receptors, CCR7; D019707:Receptors, Chemokine / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction
C515370:CCR7 protein, human; C515255:CXCL12 protein, human; D054407:Chemokine CCL4; D054377:Chemokine CXCL12; D018925:Chemokines; D019743:Chemokines, CXC; D008024:Ligands; D019402:Macrophage Inflammatory Proteins; D054400:Receptors, CCR7; D019707:Receptors, Chemokine; D019204:GTP-Binding Proteins