Attempts to measure sensitiser photophysics in opaque tissue.
Diffuse reflectance laser flash photolysis has been used in an attempt to measure transient triplet spectra of the sensitisers, disulphonated aluminium phthalocyanine and porphyrin IX (derived from 5-amino laevulinic acid), in opaque tissue and models. The latter consisted of tissue phantoms; the former included rat liver and red blood cells. In all cases, triplet-triplet absorption spectra with relatively poor signal-to-noise were obtained providing some encouragement in the application of this technique to in vivo studies on photosensitisers.
Oldham
T C
TC
Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AY, UK.
Phillips
D
D
MacRobert
A J
AJ
D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D007211:Indoles / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D010782:Photolysis; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D007211:Indoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C064331:aluminum phthalocyanine disulfonate; D000622:Aminolevulinic Acid