Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats.
Levels of red cell, serum acid, and alkaline phosphatases, serum amylase, alanine and aspartate transferase and bilirubin were examined in streptozotocin-induced diabetic rats treated with garlic oil and compared with the corresponding levels in diabetic control rats, normal rats and normal rats on garlic oil. Values of tissue amylase and total protein were also assessed from the pancreas, liver, and kidney. Treatment of diabetic rats with garlic oil significantly decreased the red cell phosphatase (p < 0.01), serum acid and alkaline phosphatase (p<0.001) when compared to diabetic control rats. Serum alanine and asparate transferases were significantly (p<0.001) decreased as well as serum amylase (p<0.002) in garlic oil treated diabetic rats as compared with diabetic control rats. When treated with garlic oil, however, diabetic and normal rats showed significant increase (p <0.05) in the amylase levels of the pancrease, liver, and kidney.
Ohaeri
O C
OC
Department of Biochemistry, Faculty of Medical Sciences, University of Jos, Nigeria.
D000135:Acid Phosphatase / Q000097:blood / Q000187:drug effects; D000469:Alkaline Phosphatase / Q000097:blood / Q000187:drug effects; D000498:Allyl Compounds / Q000494:pharmacology*; D000681:Amylases / Q000097:blood / Q000187:drug effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology*; D015536:Down-Regulation / Q000187:drug effects* / Q000502:physiology; D004798:Enzymes / Q000097:blood / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000633:toxicity; D013440:Sulfides / Q000494:pharmacology*; D000637:Transaminases / Q000097:blood / Q000187:drug effects; D015854:Up-Regulation / Q000187:drug effects* / Q000502:physiology
D000498:Allyl Compounds; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001786:Blood Glucose; D001798:Blood Proteins; D004798:Enzymes; D013440:Sulfides; D013311:Streptozocin; C038491:allyl sulfide; D000637:Transaminases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000681:Amylases