title: Combined modality treatment for locally advanced squamous-cell carcinoma of the oropharynx in a woman with Bloom's syndrome: a case report and review of the literature.
abstract: We describe a case of locally advanced unresectable squamous-cell carcinoma of the oropharynx in a young woman with Bloom's syndrome. She was treated with radical radiation therapy and concurrent chemotherapy (cisplatin and 5-flurouracil). She was unable to complete treatment due to the development of severe side effects: confluent mucositis, moist desquamating skin reaction, severe diarrhea and severe myelosupression with neutropenic sepsis. The limited relevant literature is presented. We conclude that chemotherapy should be used with extreme caution in Bloom's syndrome patients.
authors.affiliation: Division of Medical Oncology, Petcr MacCallum Cancer Institute, Melbourne, Victoria, Australia.
authors.forename: B
authors.initials: B
authors.lastname: Ma
authors.forename: J
authors.initials: J
authors.lastname: Corry
authors.forename: D
authors.initials: D
authors.lastname: Rischin
authors.forename: T
authors.initials: T
authors.lastname: Leong
authors.forename: L J
authors.initials: LJ
authors.lastname: Peters
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001816:Bloom Syndrome / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects; D006801:Humans; D009361:Neoplasm Invasiveness; D009959:Oropharyngeal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D018714:Radiotherapy, Adjuvant
chemical_list: D000964:Antimetabolites, Antineoplastic; D002945:Cisplatin; D005472:Fluorouracil