[Membrane platelet receptors and cardiovascular risk: from structure to potential clinical implications].
Platelets exhibit membrane receptor proteins the structure of which has adapted, in the course of evolution, to halt hemorrhage. These receptors are also implicated in thrombosis, and their structural variability is likely able to account for part of the variability in intraindividual susceptibility to thrombotic events. This review offers a summary of current knowledge on the molecular structure and function of platelet membrane receptors, here studied also in relation to the variability of platelet function in the general population, with the aim of discussing possible implications for the atherothrombotic risk.
Carluccio
M
M
Dipartimento Cardio Toracico, Università degli Studi, Pisa.
Vesentini
N
N
De Caterina
R
R
D001161:Arteriosclerosis / Q000209:etiology*; D006801:Humans; D010980:Platelet Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology*; D014841:von Willebrand Factor / Q000502:physiology
D010980:Platelet Membrane Glycoproteins; D014841:von Willebrand Factor
Recettori piastrinici di membrana e rischio cardiovascolare: dalla struttura alle possibili implicazioni cliniche.