title: Polymeric microspheres composed of pH/temperature-sensitive polymer complex.
abstract: A new pH/temperature-sensitive polymer system with transitions resulting both from polymer-water and polymer-polymer interactions has been demonstrated using the mixture of poly(N,N-dimethylamino)ethyl methacrylate (DMAEMA) and polyethyl acrylamide (EAAm). Based on the pH/temperature sensitivity of polymer mixture, the microsphere for pH/temperature-sensitive drug release have been designed and characterized. Hydrocortisone was used as a model drug. This gave the control of hydrocortisone release in an on-off manner without considerable lag time.
authors.affiliation: Advanced Materials Division, Korea Research Institute of Chemical Technology, Yusung, Taejeon, South Korea.
authors.forename: E J
authors.initials: EJ
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Cho
authors.forename: S H
authors.initials: SH
authors.lastname: Yuk
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D016503:Drug Delivery Systems; D006854:Hydrocortisone / Q000008:administration & dosage; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry; D008863:Microspheres; D009757:Nylons / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013696:Temperature; D013816:Thermodynamics; D014867:Water
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D009757:Nylons; D011108:Polymers; C109846:poly(2-(diethylamino)ethyl methacrylate); D014867:Water; D006854:Hydrocortisone