title: Carboplatin and oxaliplatin decomposition in chloride medium, monitored by XAS.
abstract: The stability of carboplatin and oxaliplatin aqueous solutions has been studied under different chloride ions concentration and pH conditions. For both compounds, we demonstrate the chloration of the platinum first coordination shell.
authors.affiliation: Laboratoire de Biomathématique - Faculté de Pharmacie, Université Paris 5, France.
authors.forename: E
authors.initials: E
authors.lastname: Curis
authors.forename: K
authors.initials: K
authors.lastname: Provost
authors.forename: D
authors.initials: D
authors.lastname: Bouvet
authors.forename: I
authors.initials: I
authors.lastname: Nicolis
authors.forename: S
authors.initials: S
authors.lastname: Crauste-Manciet
authors.forename: D
authors.initials: D
authors.lastname: Brossard
authors.forename: S
authors.initials: S
authors.lastname: Bénazeth
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D016190:Carboplatin / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry; D004355:Drug Stability; D005583:Fourier Analysis; D006863:Hydrogen-Ion Concentration; D009944:Organoplatinum Compounds / Q000737:chemistry*; D000077150:Oxaliplatin; D012996:Solutions; D013052:Spectrometry, X-Ray Emission / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D002712:Chlorides; D009944:Organoplatinum Compounds; D012996:Solutions; D000077150:Oxaliplatin; D016190:Carboplatin; D002945:Cisplatin