title: Squamous cell carcinoma in situ arising in inflammatory cloacogenic polyps: report of two cases with PCR analysis for HPV DNA.
abstract: Inflammatory cloacogenic polyp (ICP) is regarded as part of the spectrum of pathological changes encountered in mucosal prolapse syndrome (MPS)/solitary rectal ulcer. We present the clinicopathological features of two females with squamous cell carcinoma in situ arising in their ICPs. Human papillomavirus (HPV) type 16 was demonstrated in the areas of squamous carcinoma in situ in both polyps by polymerase chain reaction. These cases highlight the need for close scrutiny of the squamous components of these lesions.
authors.affiliation: Department of Tissue Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales, Australia.
authors.forename: R C
authors.initials: RC
authors.lastname: Jaworski
authors.forename: S A
authors.initials: SA
authors.lastname: Biankin
authors.forename: P J
authors.initials: PJ
authors.lastname: Baird
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000473:pathology* / Q000821:virology; D002278:Carcinoma in Situ / Q000473:pathology* / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D003111:Colonic Polyps / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology; D016133:Polymerase Chain Reaction; D012005:Rectal Prolapse / Q000150:complications / Q000473:pathology; D013577:Syndrome; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology; D014456:Ulcer / Q000150:complications / Q000473:pathology
chemical_list: D004279:DNA, Viral