title: [Kidney insufficiency and persistent hypotension following compromise of the renin-angiotensin system in a fetus and a young infant].
abstract: A newborn girl had chronic renal failure following prenatal exposure to an angiotensin-converting enzyme (ACE) inhibitor, and a young infant with congenital nephrotic syndrome, showed persistent hypotension with neurological complications following bilateral nephrectomy at the age of 4 months. Both died. The renin-angiotensin system (RAS) is well-known for its regulatory function with respect to blood pressure, renal haemodynamics, fluid balance and electrolyte balance. Furthermore, its role in growth and differentiation of the kidneys and urinary tracts is becoming clearer. The RAS is highly important for the foetus and young infant. Extreme caution should be exercised with prenatal exposure to ACE inhibitors or angiotensin receptor blockers and bilateral nephrectomy in young infants.
authors.affiliation: Universitair Medisch Centrum St Radboud, afd. Kindergeneeskunde, Postbus 9101, 6500 HB Nijmegen.
authors.forename: A F
authors.initials: AF
authors.lastname: van Lieburg
authors.forename: L A
authors.initials: LA
authors.lastname: Monnens
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000209:etiology*; D007223:Infant; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000209:etiology*; D009392:Nephrectomy / Q000009:adverse effects*; D009404:Nephrotic Syndrome / Q000151:congenital / Q000601:surgery*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012084:Renin-Angiotensin System / Q000187:drug effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors
vernacular_title: Nierinsufficiëntie en persisterende hypotensie na beïnvloeding van het renine-angiotensinesysteem bij een foetus en een jonge zuigeling.