title: Radical trachelectomy in early stage carcinoma of the cervix: outcome as judged by recurrence and fertility rates.
abstract: The recurrence and fertility rates in 30 women undergoing radical trachelectomy for early stage invasive cervical cancer at St Bartholomew's and Royal Marsden Hospital were reviewed. There were no recurrences, and the mean follow up was 23 months (range 1-64 months). Of 13 women trying to have a baby, eight had conceived with a total of 14 pregnancies and nine live births. Two were still trying and three were experiencing sub-fertility. There were seven premature deliveries and one late miscarriage. Six of the preterm births and the late miscarriage were associated with prelabour spontaneous rupture of membranes. This conservative yet locally radical procedure for a highly selected group of women who wished to preserve their fertility appears to offer a safe alternative to radical hysterectomy in early invasive cervical cancer.
authors.affiliation: Department of Gynaecological Oncology, St Bartholomew's Hospital, East London Cancer Centre, London, UK.
authors.forename: J H
authors.initials: JH
authors.lastname: Shepherd
authors.forename: T
authors.initials: T
authors.lastname: Mould
authors.forename: D H
authors.initials: DH
authors.lastname: Oram
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D002277:Carcinoma / Q000601:surgery*; D018196:Carcinoma, Adenosquamous / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D002584:Cervix Uteri / Q000601:surgery*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D011247:Pregnancy / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000601:surgery*