title: [Adaptive effects of hypoxic preconditioning in brain neurons].
abstract: A preventive short-term hypoxia (preconditioning) increases neuronal resistance against subsequent strong hypoxic effects. Literature review and authors' own data on molecular-cellular mechanisms of the hypoxic preconditioning, are presented. Participation of intracellular signal transduction, genome, stress-proteins, and neuromodulating peptides in this process, is discussed. The role of glutamatergic as well as calcium and phosphoinositide regulatory systems and neuromodulating factors as the components of a "volume" signal transmission are analyzed in hypoxic precondition-associated induction of functional tolerance mechanisms against acute harmful effects in neurones of olfactory slices.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6.
authors.forename: M O
authors.initials: MO
authors.lastname: Samoĭlov
authors.forename: E V
authors.initials: EV
authors.lastname: Lazarevich
authors.forename: D G
authors.initials: DG
authors.lastname: Semenov
authors.forename: A A
authors.initials: AA
authors.lastname: Mokrushin
authors.forename: E I
authors.initials: EI
authors.lastname: Tiul'kova
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Romanovskiĭ
authors.forename: E A
authors.initials: EA
authors.lastname: Miliakova
authors.forename: K N
authors.initials: KN
authors.lastname: Dudkin
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D015687:Cell Hypoxia; D016678:Genome; D006360:Heat-Shock Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D006360:Heat-Shock Proteins
vernacular_title: Adaptivnye éffekty gipoksicheskogo prekonditsionirovaniia neĭronov mozga.