title: Screening of Malian medicinal plants for antifungal, larvicidal, molluscicidal, antioxidant and radical scavenging activities.
abstract: A total of 78 different extracts from 20 medicinal plants belonging to 14 plant families from Mali were tested for their antifungal, larvicidal, molluscicidal, antioxidant and radical scavenging activities. Dichloromethane, methanol, water and ethanol extracts were used. TLC autobiography for antifungal activity was run with Cladosporium cucumerinum and Candida albicans. Extracts were also tested on the larvae of the mosquitoes Aedes aegypti, Anopheles gambiae and Culex quinquefasciatus. Molluscicidal activities were established with the snails Biomphalaria glabrata, Biomphalaria pfeifferi and Bulinus truncatus. beta-Carotene and DPPH solutions sprayed on TLC plates were used for antioxidant and radical scavenging assays. Of the extracts investigated, 20% were antioxidant and radical scavengers, 19% fungicidal, 30% were larvicidal and 11% were molluscicidal. Three of the plant extracts, from Cussonia barteri (Araliaceae), Glinus oppositifolius (Aïzoaceae) and Lannea velutina (Anacardiaceae) gave positive responses in all four tests.
authors.affiliation: Institute of Pharmacognosy and Phytochemistry, University of Lausanne, B.E.P., CH-1015 Lausanne, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Diallo
authors.forename: A
authors.initials: A
authors.lastname: Marston
authors.forename: C
authors.initials: C
authors.lastname: Terreaux
authors.forename: Y
authors.initials: Y
authors.lastname: Touré
authors.forename: B S
authors.initials: BS
authors.lastname: Paulsen
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
mesh_terms: D000330:Aedes / Q000187:drug effects; D000818:Animals; D000852:Anopheles / Q000187:drug effects; D000935:Antifungal Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D001700:Biomphalaria / Q000187:drug effects; D002033:Bulinus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002963:Cladosporium / Q000187:drug effects; D003465:Culex / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008302:Mali; D016488:Medicine, African Traditional; D008826:Microbial Sensitivity Tests; D008975:Molluscacides / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D007306:Insecticides; D008975:Molluscacides; D010936:Plant Extracts