title: Quantitative trait loci for body weight in the intercross between SM/J and A/J mice.
abstract: We performed a genome-wide quantitative trait locus (QTL) analysis of body weight at 10 weeks of age in a population of 321 intercross offspring from SM/J and A/J mice, progenitor strains of SMXA recombinant inbred strains. Interval mapping revealed two significant QTLs, Bwq3 (body weight QTL3) and Bwq4, on Chromosomes (Chrs) 8 and 18 respectively, and five suggestive QTLs on Chrs 2, 6, 7, 15 and 19. Bwq3 and Bwq4 explained 6% of the phenotypic variance. The SM/J alleles at both QTLs increased body weight, though the SM/J mouse was smaller than the A/J mouse. On the other hand, four of the five suggestive QTLs detected had male-specific effects on body weight and the remainder was female-specific. These suggestive QTLs explained 5-6% of the phenotypic variance and all the SM/J alleles decreased body weight.
authors.affiliation: Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: R V
authors.initials: RV
authors.lastname: Anunciado
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: A
authors.initials: A
authors.lastname: Ishikawa
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: F
authors.initials: F
authors.lastname: Horio
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: T
authors.initials: T
authors.lastname: Namikawa
mesh_terms: D000483:Alleles; D000818:Animals; D001835:Body Weight / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D005819:Genetic Markers; D014644:Genetic Variation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010375:Pedigree; D010641:Phenotype; D019655:Quantitative Trait, Heritable
chemical_list: D005819:Genetic Markers