Transcranial magnetic stimulation of left prefrontal cortex impairs working memory.
OBJECTIVE
Several lines of evidence suggest that the prefrontal cortex is involved in working memory. Our goal was to determine whether transient functional disruption of the dorsolateral prefrontal cortex (DLPFC) would impair performance in a sequential-letter working memory task.


METHODS
Subjects were shown sequences of letters and asked to state whether the letter just displayed was the same as the one presented 3-back. Single-pulse transcranial magnetic stimulation (TMS) was applied over the DLPFC between letter presentations.


RESULTS
TMS applied over the left DLPFC resulted in increased errors relative to no TMS controls. TMS over the right DLPFC did not alter working memory performance.


CONCLUSIONS
Our results indicate that the left prefrontal cortex has a crucial role in at least one type of working memory.
Mull
B R
BR
Department of Neurology, Section of Clinical Neurophysiology, University of California, Davis, 2315 Stockton Boulevard, Room 5308, Sacramento, CA 95817, USA.
Seyal
M
M
D000328:Adult; D004292:Dominance, Cerebral / Q000502:physiology*; D004558:Electric Stimulation; D006801:Humans; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation