Titanium-mediated alkylative cyclizations of 1,3-diene-tethered esters.
[reaction: see text]. An alkylative titanium-mediated cyclization reaction of 1,3-diene-tethered carboxylic esters has been developed by employing an in situ generated titanacyclopropane intermediate to afford trans-2-alkenyl cyclohexanols.
Quan
L G
LG
Department of Chemistry, University of Alabama, Tuscaloosa, Alabama 35487, USA.
Cha
J K
JK