Antimutagenicity of deacylated anthocyanins in purple-fleshed sweetpotato.
The antimutagenicity of the 3-sophoroside-5-glucoside of cyanidin and 3-sophoroside-5-glucoside of peonidin, the anthocyanin derivatives deacylated from the 3-(6,6'-caffeylferulylsophoroside)-5-glucoside of cyanidin (YGM-3) and 3-(6,6'-caffeylferulylsophoroside)-5-glucoside of peonidin (YGM-6) which had been purified from the sweetpotato with purple-colored flesh, was investigated by using Salmonella typhimurium TA 98. A comparison of the antimutagenicity between YGM-3 and YGM-6 and the deacylated derivatives showed that the activity of cyanidin was stronger than that of peonidin. Deacylation of the peonidin-type pigment markedly decreased this antimutagenicity. Caffeic acid showed the strongest antimutagenicity of the constituent organic acids of the anthocyanin pigments, caffeic acid, ferulic acid, and p-hydroxybenzoic acid. These results suggest that the cathecol structure plays an important role in the strong antimutagenicity of anthocyanin pigments.
Yoshimoto
M
M
Department of Upland Farming, Kyushu National Agricultural Experiment Station, Miyakonojo, Miyazaki, Japan. mak825@mykz.affrc.go.jp
Okuno
S
S
Yamaguchi
M
M
Yamakawa
O
O
D000107:Acetylation; D000872:Anthocyanins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027723:Ipomoea batatas / Q000737:chemistry*; D015394:Molecular Structure; D009152:Mutagenicity Tests; D010858:Pigmentation; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D000872:Anthocyanins; D016587:Antimutagenic Agents