title: Atypical focal non-neoplastic brain changes in neurofibromatosis type 1: mass effect and contrast enhancement.
abstract: Children and young adults with neurofibromatosis type 1 often have small high-signal foci on T2-weighted images of the brain. We describe follow-up of two patients in whom one of the foci had atypical features, commonly regarded as signs of a neoplasm. In the first, one lesion showed temporary contrast enhancement and decreasing mass effect. The second developed an expanding lesion that increased minimally in size over 4.5 year's follow-up. The borderline between neoplastic and non-neoplastic lesions seems to be indistinct.
authors.affiliation: Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Sweden. raili.raininko@radiol.uu.se
authors.forename: R
authors.initials: R
authors.lastname: Raininko
authors.forename: L
authors.initials: L
authors.lastname: Thelin
authors.forename: O
authors.initials: O
authors.lastname: Eeg-Olofsson
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000473:pathology