title: Management of puberty in constitutional delay of growth and puberty.
abstract: Constitutional delay of growth and puberty (CDGP) is the most common presenting form of short stature, but no single test can infallibly discriminate CDGP and isolated hypogonadotrophic hypogonadism. Management of puberty in CDGP aims to optimise not only growth maintaining body proportions and improving peak bone mass without impairing growth potential--but also well-being; for example, the distress boys often suffer because of their lack of growth and pubertal progression can affect their school performance and social relationships. Typical sex steroid treatments to induce puberty in boys with CDGP include testosterone (T) enanthate, T undecanoate, mixed T esters, T transdermal patches, and oxandrolone p.o. Compared with other regimens, short-course low-dose depot T i.m. is an effective, practical, safe, well tolerated, and inexpensive regimen. Some unresolved problems in management include optimal timing and dose of sex steroid treatment, the role of GH in CDGP, and the management of CDGP in girls.
authors.affiliation: Paediatric Clinic II, University Policlinic-Padiglione NI, Messina, Italy. francescodeluca@unime.it
authors.forename: F
authors.initials: F
authors.lastname: De Luca
authors.forename: J
authors.initials: J
authors.lastname: Argente
authors.forename: L
authors.initials: L
authors.lastname: Cavallo
authors.forename: E
authors.initials: E
authors.lastname: Crowne
authors.forename: H A
authors.initials: HA
authors.lastname: Delemarre-Van de Waal
authors.forename: C
authors.initials: C
authors.lastname: De Sanctis
authors.forename: S
authors.initials: S
authors.lastname: Di Maio
authors.forename: E
authors.initials: E
authors.lastname: Norjavaara
authors.forename: W
authors.initials: W
authors.lastname: Oostdijk
authors.forename: F
authors.initials: F
authors.lastname: Severi
authors.forename: G
authors.initials: G
authors.lastname: Tonini
authors.forename: G
authors.initials: G
authors.lastname: Trifirò
authors.forename: P G
authors.initials: PG
authors.lastname: Voorhoeve
authors.forename: F
authors.initials: F
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D005260:Female; D012739:Gonadal Steroid Hormones / Q000627:therapeutic use; D006130:Growth Disorders / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D011627:Puberty / Q000502:physiology*; D011628:Puberty, Delayed / Q000503:physiopathology / Q000628:therapy*
chemical_list: D012739:Gonadal Steroid Hormones