title: Bartonellosis (Carrión's disease) in the modern era.
abstract: Bartonellosis remains a major problem in Peru, but many contemporary aspects of this disease have not been adequately described. We examined the cases of 145 symptomatic patients in Lima, Peru, in whom bartonellosis was diagnosed from 1969 through 1992, including 68 patients in the acute (hematic) phase and 77 patients in the eruptive (verruga) phase. In modern Peru, symptomatic patients who have acute-phase bartonellosis typically present with a febrile illness and systemic symptoms caused by profound anemia; most patients respond successfully to treatment with chloramphenicol. Patients who have eruptive-phase bartonellosis most often present with cutaneous verrugas but may have less specific symptoms, such as fever and arthralgias; diagnosis can be confirmed in such patients by Western immunoblotting, and most patients appear to respond to treatment with rifampin.
authors.affiliation: Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano, Heredia, Lima, Peru.
authors.forename: C
authors.initials: C
authors.lastname: Maguina
authors.forename: P J
authors.initials: PJ
authors.lastname: Garcia
authors.forename: E
authors.initials: E
authors.lastname: Gotuzzo
authors.forename: L
authors.initials: L
authors.lastname: Cordero
authors.forename: D H
authors.initials: DH
authors.lastname: Spach
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001474:Bartonella Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010568:Peru / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D012293:Rifampin