The effect of hydroxyapatite ultrofine powder on the immunity function of tumor-bearing mice.
The inhibitory effect of hydroxyapatite ultrofine powder (HAUFP) on tumor and the effect on the immunity function of body were investigated. The levels of IL-2 in the spleen cells and serum TNF levels in the tumor-bearing mice at the 7th day and 14th after peritoneal injection of HAUFP were detected by using the methods of colorimetric analysis of MTT and crystal purple decoration, respectively. The disappearance of the ascites of the mice was observed. The results showed that the levels of IL-2 and TNF in the tumor-bearing mice were higher obviously in the drug-treated group than in the control group (P < 0.01), the ascites growth was inhibited. It was suggested that HAUFP could increase the levels of IL-2 and TNF of the tumor-bearing mice and improve the immune function of body.
Xia
Q
Q
Department of General Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Nie
H
H
Chen
D
D
Yan
Y
Y
Feng
L
L
Li
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005260:Female; D006882:Hydroxyapatites / Q000494:pharmacology*; D007376:Interleukin-2 / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology*; D011208:Powders; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000970:Antineoplastic Agents; D006882:Hydroxyapatites; D007376:Interleukin-2; D011208:Powders; D014409:Tumor Necrosis Factor-alpha