[A case of IgG4-lambda type monoclonal immunoglobulin that interfered with determinations for albumin, direct bilirubin and iron in serum].
We report a human IgG4-lambda type M-protein that reacts with reagents of albumin, direct bilirubin and iron. Blood chemistry findings by an automated analyzer were: total protein 8.8 g/dl; albumin(ALB) 9.2 g/dl; direct bilirubin(D-Bil) -6.2 mg/dl; and iron(Fe) 25 micrograms/dl. The white precipitates were formed by the interaction of the patient's serum with reagents of ALB, D-Bil, and Fe. Immunofixation electrophoresis revealed that these precipitates were the IgG4-lambda type M-protein. Western blotting analysis showed that the IgG4 molecules were composed of two 55 kDa gamma 4 chains and two 24 kDa lambda chains.
Aoki
Y J
YJ
Clinical Laboratory, Nagano Municipal Hospital, Nagano 381-8551.
Kameko
M
M
Fujita
K
K
D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins; D001663:Bilirubin; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000737:chemistry; D007202:Indicators and Reagents; D007501:Iron; D008297:Male; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis*
D000418:Albumins; D007074:Immunoglobulin G; D007202:Indicators and Reagents; D007501:Iron; D001663:Bilirubin