title: Cadherin function: breaking the barrier.
abstract: Three desmoglein isoforms collaborate with desmocollins to build the adhesive core of desmosomes. A recent study has shown that altering the ratio of desmoglein isoforms influences epidermal barrier function, suggesting distinct roles for these cadherins that extend beyond adhesion.
authors.affiliation: Departments of Pathology and Dermatology, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois 60611, USA.
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: K J
authors.initials: KJ
authors.lastname: Green
mesh_terms: D000818:Animals; D015820:Cadherins / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology; D051187:Desmocollins; D051182:Desmogleins; D051180:Desmoplakins; D003896:Desmosomes / Q000502:physiology; D004817:Epidermis / Q000502:physiology; D006801:Humans; D020033:Protein Isoforms / Q000502:physiology
chemical_list: D015820:Cadherins; D003598:Cytoskeletal Proteins; D051187:Desmocollins; D051182:Desmogleins; D051180:Desmoplakins; D020033:Protein Isoforms