Adaptogenic activity of a glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaertn.
A glyco-peptido lipid fraction ("AF") from the alcoholic extract of Trichopus zeylanicus Gaertn. was evaluated for putative antistress activity in a battery of tests. "AF" exhibited significant antistress activity in dose dependent manner in all the parameters studied, against the different stresses use to induce non-specific stress. Ashwagandha, the commercial extract of Withania somnifera roots was used as control: A preliminary acute toxicity study in mice showed a good margin of safety, as the ALD50 value was more than 3000 mg/kg body wt. p.o. with no signs of abnormalities.
Singh
B
B
Department of Pharmacology, Regional Research Laboratory, Jammu-Tawi, India. rrlj@nde.vsnl.net.in
Gupta
D K
DK
Chandan
B K
BK
D000223:Adaptation, Psychological / Q000187:drug effects; D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D006017:Glycolipids / Q000302:isolation & purification / Q000494:pharmacology; D006020:Glycopeptides / Q000302:isolation & purification / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010940:Plant Proteins / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006017:Glycolipids; D006020:Glycopeptides; D010936:Plant Extracts; D010940:Plant Proteins; D002351:Carrageenan