Birth after intracytoplasmic sperm injection with use of testicular sperm from men with Kartagener/immotile cilia syndrome.
OBJECTIVE
To describe two cases of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) with testicular sperm in men with immotile cilia syndromes.


METHODS
Case report.


METHODS
A university-based male infertility clinic and assisted reproduction unit.


METHODS
Two couples with male factor infertility due to Kartagener/immotile cilia syndrome.


METHODS
IVF/ICSI with testicular sperm.


METHODS
Semen characteristics, sperm viability, fertilization rate, and pregnancy.


RESULTS
With testicular sperm, the two pronuclear fertilization rates were 63% and 60% in two cases. One case resulted in the birth of normal healthy girl.


CONCLUSIONS
With testicular sperm, successful oocyte fertilization after ICSI in couples with male Kartagener/immotile cilia syndrome is possible despite the lack of sperm motility.
Cayan
S
S
Department of Urology, University of California San Francisco School of Medicine, San Francisco, CA 94115-1695, USA.
Conaghan
J
J
Schriock
E D
ED
Ryan
I P
IP
Black
L D
LD
Turek
P J
PJ
D000328:Adult; D002925:Ciliary Motility Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007619:Kartagener Syndrome / Q000503:physiopathology*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D013076:Sperm Count; D020554:Sperm Injections, Intracytoplasmic; D013081:Sperm Motility; D013094:Spermatozoa / Q000502:physiology*; D013737:Testis