Neuroactive steroid levels in patients with generalized anxiety disorder.
Serum levels of allopregnanolone, pregnenolone sulfate, and dehydroepiandrosterone sulfate were measured in 8 male patients with generalized anxiety disorder (GAD) and 8 healthy control subjects. Results suggest that patients with GAD have significantly lower levels of pregnenolone sulfate than control subjects.
Semeniuk
T
T
Department of Psychiatry, University of Alberta Hospital, Edmonton, Alberta, Canada. tsemeniu@ualberta.ca
Jhangri
G S
GS
Le Mellédo
J M
JM
D000328:Adult; D001008:Anxiety Disorders / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D011280:Pregnanolone / Q000378:metabolism*; D011284:Pregnenolone / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011963:Receptors, GABA-A; C018370:pregnenolone sulfate; D003687:Dehydroepiandrosterone; D005680:gamma-Aminobutyric Acid; D011284:Pregnenolone; D011280:Pregnanolone