Multidrug permeases and subcellular cholesterol transport.
Studies of Niemann-Pick C (NPC) and Tangier diseases have led to the identification of the causative genes, NPC1 and ABCA1, respectively. Characterization of their protein products shows that NPC1 and ABCA1 are permeases that belong to two different superfamilies of efflux pumps, which might be important in subcellular lipid and cholesterol transport.
Ioannou
Y A
YA
Department of Human Genetics, Box 1498, The Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, New York 10029, USA. yiannis.ioannou@mssm.edu
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology; D001692:Biological Transport; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D008052:Lipid Metabolism, Inborn Errors / Q000209:etiology; D026901:Membrane Transport Proteins / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D009542:Niemann-Pick Diseases / Q000209:etiology; D013347:Subcellular Fractions / Q000737:chemistry*; D013631:Tangier Disease / Q000209:etiology
D018528:ATP-Binding Cassette Transporters; D026901:Membrane Transport Proteins; D002784:Cholesterol