Evaluation of toxicity of some saponins on brine shrimp.
Toxicity of several types of saponins (1-11) against brine shrimp (Artemia salina) were evaluated. As a result, it was found that most tested compounds were not toxic to brine shrimp at high enough concentration. The most toxic saponin (1) to brine shrimp showed also cytotoxicity towards HL-60 tumor cell line using MTT assay. Brine shrimp model may thus be used as bench-top assay in finding cytotoxic components from saponin-containing fractions of plant extracts.
Zhao
W M
WM
Shanghai Institute of Materia Medica, Chinese Academy of Sciences. wmzhao@mail.shcnc.ac.cn
Qin
G W
GW
Lou
L G
LG
D000818:Animals; D033364:Decapoda / Q000187:drug effects*; D018922:HL-60 Cells; D006801:Humans; D012503:Saponins / Q000633:toxicity*
D012503:Saponins