title: Treatment of infrabony pocket with a collagen membrane supported by cancellous bovine bone.
abstract: BACKGROUND
  Treatment of infrabony pockets with guided tissue regeneration (GTR) methods using absorbable membranes supported by bone substitutes has gained wide acceptance. Our objective is to observe the clinical variations obtained with the use of these materials in a prospective clinical study.
  
  
  METHODS
  Nine patients were treated with GTR at nine infrabony pockets using a double layered collagen membrane and deproteinized cancellous bovine bone associated with root conditioning by application of tetracycline-HCl. The nine patients included in this study had adult periodontitis, were non-smokers and responded well to initial therapy. The sites evaluated had probing pocket depths of at least 5 mm and an angular defect of at least 2 mm. The clinical parameters considered were probing pocket depth (PPD), clinical attachment level (CAL) and gingival recession (REC). Some indexes were also evaluated: the modified Quigley and Hein's Plaque index (PI), O'Leary's bleeding index (FMBS) and the Löe and Sillness gingival index (GI). These parameters were measured one week before surgery and at the control visit after an average of 22.9 months. After the removal of the sutures on the eighth day the patients received professional oral hygene every four months at their private dentists' offices. The baseline and the final measurements were compared with the Student OtO-test to verify the statistical significance of this case series.
  
  
  RESULTS
  The mean values of PI, FMBS and GI remained unvaried (p>0.05). Results showed an average decrease in PPD of 4.0+/-2.7 mm (p=0.0002), an average increase of CAL of 4.1+/-2.1 mm (p=0.0001) and an average decrease in recession of 0.2+/-1.2 mm (p=0.594). The value of statistical significance was set at p=0.05.
  
  
  CONCLUSIONS
  We can conclude that the materials used in this study behaved well clinically and that the surgical technique described has given results that, within the limits of the number of cases reported, has modified the PPD and CAL in a significant manner.
authors.affiliation: Dipartimento di Odontostomatologia, Cattedra di Parodontologia, Università degli Studi, Firenze, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Mauro
authors.forename: L
authors.initials: L
authors.lastname: Orlando
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000628:therapy*; D000818:Animals; D016025:Bone Transplantation; D002417:Cattle; D003094:Collagen; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010514:Periodontal Pocket / Q000628:therapy*; D011446:Prospective Studies
chemical_list: D008567:Membranes, Artificial; D003094:Collagen