title: Airway pressure release ventilation increases cardiac performance in patients with acute lung injury/adult respiratory distress syndrome.
abstract: BACKGROUND
  The purpose of the present study is to determine whether airway pressure release ventilation (APRV) can safely enhance hemodynamics in patients with acute lung injury (ALI) and/or adult respiratory distress syndrome (ARDS), relative to pressure control ventilation (PCV).
  
  
  METHODS
  Patients with severe acute lung injury or ARDS who were managed with inverse-ratio pressure control ventilation, neuromuscular blockade and a pulmonary artery catheter were switched to APRV. Hemodynamic performance, as well as pressor and sedative needs, was assessed after discontinuing neuromuscular blockade
  
  
  RESULTS
  Mean age was 58 +/- 9 years (n = 12) and mean Lung Injury Score was 7.6 +/- 2.1. Temperature and arterial oxygen tension/fractional inspired oxygen (FiO2) were similar among the patients. Peak airway pressures fell from 38 +/- 3 for PCV to 25 +/- 3 cmH2O for APRV, and mean pressures fell from 18 +/- 3 for PCV to 12 +/- 2 cmH2O for APRV. Paralytic use and sedative use were significantly lower with APRV than with PCV. Pressor use decreased substantially with ARPV. Lactate levels remained normal, but decreased on APRV. Cardiac index rose from 3.2 +/- 0.4 for PCV to 4.6 +/- 0.3 l/min per m2 body surface area (BSA) for APRV, whereas oxygen delivery increased from 997 +/- 108 for PCV to 1409 +/- 146 ml/min for APRV, and central venous pressure declined from 18 +/- 4 for PCV to 12 +/- 4 cmH2O for APRV. Urine output increased from 0.83 +/- 0.1 for PCV to 0.96 +/- 0.12 ml/kg per hour for APRV.
  
  
  CONCLUSIONS
  APRV may be used safely in patients with ALI/ARDS, and decreases the need for paralysis and sedation as compared with PCV-inverse ratio ventilation (IRV). APRV increases cardiac performance, with decreased pressor use and decreased airway pressure, in patients with ALI/ARDS.
authors.affiliation: Medical College of PA-Hahnemann University, Department of Surgery, 3300 Henry Avenue, Philadelphia, PA 19129, USA. Lewis.Ka[lan@drexel.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: Kaplan
authors.forename: H
authors.initials: H
authors.lastname: Bailey
authors.forename: V
authors.initials: V
authors.lastname: Formosa
mesh_terms: D000328:Adult; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007362:Intensive Care Units; D008875:Middle Aged; D019148:Neuromuscular Blockade; D010865:Pilot Projects; D011175:Positive-Pressure Respiration / Q000379:methods; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D013318:Stroke Volume
chemical_list: D006993:Hypnotics and Sedatives