title: Protective effect of N-acetylcysteine in isoniazid induced hepatic injury in growing rats.
abstract: Status of oxidative/antioxidative profile was the mechanistic approach to inumerate the nature of protection by N-acetylcysteine (NAC) in isoniazid (INH) exposed experimental animals. Analysis of lipid peroxidation, thiol levels, cytochrome P450, superoxide dismutase (SOD), catalase, glutathione peroxidase, reductase and transferase were estimated in liver along with the body and liver weight of animals and histological observations. Isoniazid exposure to animals resulted in no change in body and liver weights. Thiols, lipid peroxidation, catalase, SOD glutathione peroxidase, reductase, transferase and cytochrome P450 levels were altered with INH exposure. Supplementation of NAC with INH protected the animals against hepatotoxic reactions by minimizing the free radical induced tissue injury and overall maintenance of the endogenous scavengers of free radicals.
authors.affiliation: Department of Biochemistry, Govt. Medical College, Chandigarh 160 032, India.
authors.forename: S
authors.initials: S
authors.lastname: Attri
authors.forename: S V
authors.initials: SV
authors.lastname: Rana
authors.forename: K
authors.initials: K
authors.lastname: Vaiphie
authors.forename: R
authors.initials: R
authors.lastname: Katyal
authors.forename: C P
authors.initials: CP
authors.lastname: Sodhi
authors.forename: S
authors.initials: S
authors.lastname: Kanwar
authors.forename: K
authors.initials: K
authors.lastname: Singh
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D016166:Free Radical Scavengers / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007538:Isoniazid / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D008297:Male; D016877:Oxidants / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D016877:Oxidants; D005978:Glutathione; D007538:Isoniazid; D000111:Acetylcysteine