title: Successful therapy of pure red cell aplasia secondary to plasma cell dyscrasia with bolus methylprednisolone.
abstract: A 65-year-old man, who is a Jehovah's Witness, was admitted to our hospital due to progressive anemia following a four-year history of biclonal gammopathy of no clinical significance. He was diagnosed with pure red cell aplasia (PRCA) associated with plasma cell dyscrasia. Despite a markedly decreased red blood cell count (hematocrit 5.6%), the patient refused transfusion. He was intravenously administered bolus methylprednisolone. Reticulocytosis and recovery from anemia were observed on day 7 after the start of therapy. Secondary PRCA following plasma cell dyscrasia is a rare disorder; the treatments for this rare condition are discussed.
authors.affiliation: Department of Medicine, Kagawa Prefectural Central Hospital, Takamatsu.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuhashi
authors.forename: T
authors.initials: T
authors.lastname: Tasaka
authors.forename: E
authors.initials: E
authors.lastname: Uehara
authors.forename: T
authors.initials: T
authors.lastname: Kamei
authors.forename: T
authors.initials: T
authors.lastname: Tamura
authors.forename: M
authors.initials: M
authors.lastname: Nagai
mesh_terms: D000368:Aged; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D010265:Paraproteinemias / Q000150:complications*; D012010:Red-Cell Aplasia, Pure / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone