title: The insulin-like growth factor system in kidney diseases.
abstract: The insulin-like growth factor system is intimately involved in renal development, growth, function and the pathophysiology of several disease states. Exogenous IGF-I increases GFR and RPF, perhaps mediated by nitric oxide (NO). In chronic renal failure, IGF-I, the binding proteins and their fragments decrease bioavailability. After transplantation, the levels of bioactive IGF-I increase likely due to better nutrition and increased clearance of the binding proteins and their fragments. In the nephritic syndrome, a similar mechanism may be active, in that the binding proteins and their fragments may inhibit IGF-I action.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA. er7m@virginia.edu
authors.forename: E J
authors.initials: EJ
authors.lastname: Richmond
authors.forename: A
authors.initials: A
authors.lastname: Uzri
authors.forename: A D
authors.initials: AD
authors.lastname: Rogol
mesh_terms: D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology*
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I