Vertebrate development: Et in Arkadia.
The similarities in organiser formation in Xenopus and mouse embryos have remained elusive. Recent evidence suggests a common mechanism, in which an intracellular protein, Arkadia, is required for formation of the mouse organiser and potentiates the effects of the signalling protein Nodal.
Patten
I
I
MRC Intercellular Signalling Group, Centre for Developmental Genetics, Department of Biomedical Sciences, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. I.K.Patten@Sheffield.ac.uk
Placzek
M
M
D000818:Animals; D047108:Embryonic Development; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases; D014981:Xenopus
D009687:Nuclear Proteins; C427283:Rnf111 protein, mouse; D044767:Ubiquitin-Protein Ligases