An in vivo evaluation of induction of abnormal sperm morphology by some anthelmintic drugs in mice.
Using the murine sperm-head abnormality test, the mutagenicity of pyrantel pamoate, levamisole, albendazole, mebendazole and niridazole was evaluated. Pyrantel pamoate and niridazole induced increases in sperm-head abnormalities statistically significant over the negative controls at all the dose levels that were considered; the induction was dose-dependent indicating that both drugs might be mutagenic. Levamisole, albendazole, mebendazole and thiabendazole, all were unable to induce statistically significant increases in sperm-head abnormalities over the negative controls at all the dose levels tested; there was no correlation between dose level of administered drugs and incidence of abnormal sperms, indicating that the drugs might not be mutagenic.
Otubanjo
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Department of Zoology, Marine Biology and Fisheries, University of Lagos, Lagos, Nigeria. surrie19@hotmail.com
Mosuro
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D015766:Albendazole / Q000633:toxicity; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D007978:Levamisole / Q000633:toxicity; D008297:Male; D008463:Mebendazole / Q000633:toxicity; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000633:toxicity; D009560:Niridazole / Q000633:toxicity; D011716:Pyrantel Pamoate / Q000633:toxicity; D013077:Sperm Head / Q000187:drug effects / Q000473:pathology; D013094:Spermatozoa / Q000002:abnormalities* / Q000187:drug effects*
D000871:Anthelmintics; D009153:Mutagens; D007978:Levamisole; D011716:Pyrantel Pamoate; D008463:Mebendazole; D015766:Albendazole; D009560:Niridazole