Structural and functional features of glycosyltransferases.
Most of the glycosylation reactions that generate the great diversity of oligosaccharide structures of eukaryotic cells occur in the Golgi apparatus. This review deals with the most recent data that provide insight into the functional organization of Golgi-resident glycosyltransferases. We also focus on the recent successes in X-ray crystal structure determination of glycosyltransferases. These new structures begin to shed light on the molecular bases accounting for donor and acceptor substrate specificities as well as catalysis.
Breton
C
C
Centre de Recherches sur les Macromolécules Végétales, Uniiversity Joseph-Fourier, CNRS, BP 53, 38041 Grenoble cedex 9, France. breton@cermav.cnrs.fr
Mucha
J
J
Jeanneau
C
C
D000595:Amino Acid Sequence; D000818:Animals; D020134:Catalytic Domain; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006031:Glycosylation; D016695:Glycosyltransferases / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D021381:Protein Transport
D016695:Glycosyltransferases