title: Health-related quality of life in patients with chronic fatigue syndrome: an international study.
abstract: OBJECTIVE
  Chronic fatigue syndrome (CFS) has been reported worldwide. Our objectives were to determine if patients from different countries have similar profiles of impairments.
  
  
  METHODS
  Health-related quality of life (HRQoL) was assessed in 740 CFS patients in the US, 82 in the UK, and 65 in Germany using the eight subscales of the Short-Form General Health Survey (SF-36). To examine the internal structure, factor analyses were performed.
  
  
  RESULTS
  Overall, there was a remarkable similarity in HRQoL among all CFS patients, regardless of location. Patients scored two to three standard deviations below normal on six subscales and one standard deviation below normal on the other two subscales. Factor analysis suggested a two-factor model where the same six subscales constitute the first factor and the two others the second factor.
  
  
  CONCLUSIONS
  HRQoL is poor in CFS patients from three countries. This study is a first step towards conducting further comparative cross-cultural and international studies.
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Mainz, Untere Zahlbacher 8, D-55101, Mainz, Germany. hardt@mail.uni-mainz.de
authors.forename: J
authors.initials: J
authors.lastname: Hardt
authors.forename: D
authors.initials: D
authors.lastname: Buchwald
authors.forename: D
authors.initials: D
authors.lastname: Wilks
authors.forename: M
authors.initials: M
authors.lastname: Sharpe
authors.forename: W A
authors.initials: WA
authors.lastname: Nix
authors.forename: U T
authors.initials: UT
authors.lastname: Egle
mesh_terms: D000293:Adolescent; D000368:Aged; D003430:Cross-Sectional Studies; D005163:Factor Analysis, Statistical; D015673:Fatigue Syndrome, Chronic / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life