title: [Re-expression of various i-antigens in Dileptus anser after temporary transformation of serotype].
abstract: RNP particles containing 20S prosomes (alpha RNP) isolated from human epidermoid carcinoma cell line A-431 are shown to posses strong and regulated endonuclease activity specific for high-molecular-weight RNA, particularly, specific mRNAs. Furthermore, alpha-RNP destabilize the 3'-untranslated regions of c-myc mRNA, creating a specific cleavage pattern. Cleavage point within Alu sequence in high-molecular-weight RNA has been localized by primer-extension method. This RNase activity is induced under the action of EGF. alpha-RNP involvement in the coordinated control of processing and stability of specific messenger RNA molecules is suggested. The endoribonuclease activity of alpha-RNP can represent a link between EGF signalling pathway and RNA processing and degradation.
authors.affiliation: Institute of Cytology RAS, St. Petersburg.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Uspenskaia
authors.forename: A L
authors.initials: AL
authors.lastname: Iudin
mesh_terms: D000818:Animals; D000941:Antigens / Q000235:genetics*; D016798:Ciliophora / Q000276:immunology*; D003433:Crosses, Genetic; D015870:Gene Expression; D010641:Phenotype
chemical_list: D000941:Antigens
vernacular_title: Vozobnovlenie sovmestnoĭ ékspressii raznykh i-antigenov infuzoriiami Dileptus anser posle vremennoĭ transformatsii serotipa.