Pre-heparin plasma lipoprotein lipase mass: correlation with intra-abdominal visceral fat accumulation.
OBJECTIVE
To determine how lipoprotein lipase mass in the pre-heparin plasma is affected by body fat distribution, which is known to be closely related to lipid disorder, either directly or through insulin resistance.


METHODS
A total of 57 subjects consisting of 50 hyperlipidemic and 7 normolipidemic subjects (age 54 +/- IIy; 31 men, 26 women; body mass index 24+/- 2.5 kg/m2; serum total cholesterol 6.4+/-1.5 mmol/l; triglycerides, 2.4 +/- 1.7 mmol/l; HDL-cholesterol 1.3 +/- 0.5 mmol/l) were enrolled.


METHODS
We investigated the correlation between pre-heparin plasma LPL mass and intra-abdominal visceral fat area (or subcutaneous fat area) evaluated by computed tomography, and serum lipids and lipoproteins.


RESULTS
Pre-heparin plasma LPL mass correlated inversely against intra-abdominal visceral fat area (r = - 0.51, p < 0.0001) and body mass index (r = - 0.46, p = 0.0003), but did not show any significant correlation with subcutaneous fat area. Pre-heparin plasma LPL mass had a positive correlation with serum high density lipoprotein cholesterol (r = 0.45, p = 0.0004) and a negative correlation against serum triglycerides (r = - 0.48, p = 0.0002).


CONCLUSIONS
Pre-heparin plasma LPL mass is closely associated with intra-abdominal fat distribution, and the measurement of its value gives useful information concerning metabolic disorder.
Kobayashi
J
J
Health Sciences Center Chiba University, Japan. koba231@attglobal.net
Saito
K
K
Fukamachi
I
I
Taira
K
K
Takahashi
K
K
Bujo
H
H
Saito
Y
Y
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000925:Anticoagulants / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood*; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D000925:Anticoagulants; D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins; D006493:Heparin; D008071:Lipoprotein Lipase