title: Spinal chloroma presenting with triplegia in an aleukaemic patient.
abstract: Malignant myeloid blast cells may occasionally form a solid mass in tissues outside the haemopoietic system. These tumours are known as chloromas or granulocytic sarcomas. Chloromas occur most commonly in the context of acute myelogenous leukaemia but, rarely, they occur in the absence of other haematological disease, and may be misdiagnosed as lymphoma. A case of a previously well 35-year-old woman presenting with rapidly progressive triplegia caused by a paraspinal and extradural cervical chloroma with no evidence of bone marrow or other haematological involvement is described. Few cases of spinal cord compression caused by chloroma in otherwise healthy patients have been reported. Morphological features of myeloid differentiation, histochemistry and immunohistochemistry, may all aid in rapid diagnosis and allow early and appropriate therapy.
authors.affiliation: Department of Anatomical Pathology, Royal Prince Alfred Hospital and Sydney, NSW, Australia.
authors.forename: M E
authors.initials: ME
authors.lastname: Buckland
authors.forename: R A
authors.initials: RA
authors.lastname: Scolyer
authors.forename: M B
authors.initials: MB
authors.lastname: Donellan
authors.forename: S
authors.initials: S
authors.lastname: Brew
authors.forename: M
authors.initials: M
authors.lastname: McGee-Collett
authors.forename: C G
authors.initials: CG
authors.lastname: Harper
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002574:Cervical Vertebrae / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D010264:Paraplegia / Q000175:diagnosis*; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000209:etiology; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor