Synthesis and anthelmintic activity of 3,6-disubstituted-7H-s-triazolo(3,4-b)(1,3,4)thiadiazines.
A series of 3,6-disubstituted-7H-s-triazolo(3,4-b)(1,3,4)thiadiazines was synthesized by the condensation of the appropriate 3-substituted-4-amino-5-mercapto (1,2,4) triazoles with substituted phenacyl bromides in alcoholic medium. These compounds have been studied for their in vivo anthelmintic activity in albino mice. A number of compounds showed promising activity when given by the oral route.
Nadkarni
B A
BA
Department of Chemotherapy, Haffkine Institute, Mumbai, India. bharatinadkarni@usa.net
Kamat
V R
VR
Khadse
B G
BG
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004353:Drug Evaluation, Preclinical; D006925:Hymenolepiasis / Q000188:drug therapy* / Q000469:parasitology; D006926:Hymenolepis / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D051381:Rats; D013055:Spectrophotometry, Infrared; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000871:Anthelmintics; D013829:Thiadiazines; D014230:Triazoles