title: The 5,6- and 4,5-benzo derivatives of 1-hydroxy-7-azabenzotriazole.
abstract: [structure: see text]. Syntheses of the two benzo derivatives of HOAt are described. Conversion of the two isomers to the corresponding onium-style coupling reagents gave in one case a guandinium species 14 and in the other, presumably as a result of steric factors, a uronium species 15. The two systems are compared as to their effectiveness in peptide coupling processes.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, 01003, USA. carpino@chem.umass.edu
authors.forename: L A
authors.initials: LA
authors.lastname: Carpino
authors.forename: F J
authors.initials: FJ
authors.lastname: Ferrer
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D020033:Protein Isoforms; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D010455:Peptides; D020033:Protein Isoforms; D014230:Triazoles; C011852:1-hydroxybenzotriazole; C435757:1-hydroxy-7-azabenzotriazole