title: In vitro study of relationship between signal intensity and gadolinium-DTPA concentration at high magnetic field strength.
abstract: Although gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) has been used as a contrast material in MRI, it is known that the contrast enhancement effect is not uniform for high concentrations of Gd-DTPA. In order to evaluate the proper pulse sequences for dynamic MRI in aqueous solutions of Gd-DTPA, blood samples and melanoma cells, the signal intensity for several concentrations of Gd-DTPA were measured under inversion recovery (T1-weighted) at high magnetic field strength (7.0 Tesla). For aqueous solutions of Gd-DTPA, signal intensity correlated linearly with the concentration of Gd-DTPA between 0 mmol/L and 4 mmol/L. Using blood and melanoma cells, signal intensity correlated non-linearly with the concentration of Gd-DTPA between 0 mmol/L and 1.5 mmol/L. For concentrations of more than 4 mmol/L in aqueous solutions of Gd-DTPA, 1 mmol/L in blood and 1.5 mmol/L in melanoma, signal intensity decreased with increased Gd-DTPA concentration.
authors.affiliation: Centre for Experimental Radiation Oncology, University of Western Sydney, Nepean, New South Wales, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Shahbazi-Gahrouei
authors.forename: M
authors.initials: M
authors.lastname: Williams
authors.forename: B J
authors.initials: BJ
authors.lastname: Allen
mesh_terms: D001769:Blood; D003287:Contrast Media / Q000008:administration & dosage*; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D007089:Image Enhancement; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008545:Melanoma; D009994:Osmolar Concentration; D012965:Sodium Chloride; D012996:Solutions
chemical_list: D003287:Contrast Media; D012996:Solutions; D012965:Sodium Chloride; D019786:Gadolinium DTPA