title: Apnoea characteristics across the night in severe obstructive sleep apnoea: influence of body posture.
abstract: Several studies have reported changes in apnoea characteristics across the night in patients with obstructive sleep apnoea (OSA). However, the effect of body posture on these changes has not been evaluated. The purpose of this study was to assess how body posture influences sleep apnoea characteristics across the night in severe OSA. Polysomnograms of 30 patients with severe OSA who had > or = 30 apnoeic episodes in the lateral position and 30 in the supine position during Stage 2 sleep, in the early, middle and late sleep periods were analysed. For each of the 30 events in each body position, the following variables were evaluated: apnoea duration; minimum saturation; change in saturation; duration of arousal; maximum snoring loudness and change in cardiac frequency. Although at any time during the night, apnoeas in the supine posture were more severe than those in the lateral position, a time effect across the night was found only for apnoea duration, change in cardiac frequency and duration of arousal. Body position did not affect the time trend for these variables across the night. The best fit for the changes of these three variables across the night was a quadratic time trend. It was concluded that in severe obstructive sleep apnoea during Stage 2 sleep, body position does not significantly affect the time trends of apnoea characteristics across the night. These data provide support for the participation of sleep-dependent mechanisms (homeostatic and circadian) in the determination of apnoea characteristics across the night.
authors.affiliation: Sleep Disorders Unit, Loewenstein Hospital-Rehabilitation Centre, Raanana, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Oksenberg
authors.forename: I
authors.initials: I
authors.lastname: Khamaysi
authors.forename: D S
authors.initials: DS
authors.lastname: Silverberg
mesh_terms: D000328:Adult; D000368:Aged; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D017286:Polysomnography; D011187:Posture; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D012894:Sleep Stages