title: Successful resection of rectal carcinoma in an Evans' syndrome patient followed by predonisolone and high-dose immunoglobulin: report of a case.
abstract: A 69-year-old woman was admitted to our hospital because of anal bleeding and fatigue. The patient was previously diagnosed as having Evans' syndrome on the basis of hematological examination and had been treated with predonisolone for 8 years. On admission, severe anemia and thrombocytopenia were noted. Colonoscopy and Barium enema studies demonstrated an irregular tumor with hemorrhagic ulceration in the rectum, which was histopathologically confirmed as an adenocarcinoma. After red blood cells and platelets were transfused, and the patient was treated with high-dose gammaglobulin, predonisolone, and camostat mesylate, the platelet count gradually increased and hemolysis was well controlled. The patient then underwent Hartmann's operation and splenectomy without any postoperative complications. Predonisolone and high-dose immunoglobulin therapy in a rectal cancer burdened patient with Evans' syndrome is considered useful in combination with surgical treatment. This is the first case report of rectal carcinoma resection in a patient with Evans' syndrome.
authors.affiliation: Department of Surgery I, Okayama University Medical School, Japan. anakao@imap.pitt.edu
authors.forename: A
authors.initials: A
authors.lastname: Nakao
authors.forename: H
authors.initials: H
authors.lastname: Iwagaki
authors.forename: K
authors.initials: K
authors.lastname: Notohara
authors.forename: Y
authors.initials: Y
authors.lastname: Morimoto
authors.forename: N
authors.initials: N
authors.lastname: Ariki
authors.forename: T
authors.initials: T
authors.lastname: Kanagawa
authors.forename: H
authors.initials: H
authors.lastname: Isozaki
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D011239:Prednisolone / Q000008:administration & dosage*; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D013577:Syndrome; D013921:Thrombocytopenia / Q000150:complications* / Q000188:drug therapy
chemical_list: D016756:Immunoglobulins, Intravenous; D011239:Prednisolone