title: Influence of anesthesia on brain distribution of [(11)C]methamphetamine in monkeys in positron emission tomography (PET) study.
abstract: We investigated the influence of anesthesia on the brain distribution of [11C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [11C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.
authors.affiliation: Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. mizugaki@mail.cc.tohoku.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Mizugaki
authors.forename: N
authors.initials: N
authors.lastname: Nakagawa
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Hishinuma
authors.forename: Y
authors.initials: Y
authors.lastname: Tomioka
authors.forename: S
authors.initials: S
authors.lastname: Ishiwata
authors.forename: T
authors.initials: T
authors.lastname: Ido
authors.forename: R
authors.initials: R
authors.lastname: Iwata
authors.forename: Y
authors.initials: Y
authors.lastname: Funaki
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Higuchi
authors.forename: N
authors.initials: N
authors.lastname: Okamura
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Shindo
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D000759:Adjuvants, Anesthesia / Q000494:pharmacology; D000777:Anesthetics / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects* / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D006221:Halothane / Q000494:pharmacology; D008253:Macaca mulatta; D008297:Male; D008694:Methamphetamine / Q000493:pharmacokinetics*; D010424:Pentobarbital / Q000494:pharmacology; D014055:Tomography, Emission-Computed
chemical_list: D000759:Adjuvants, Anesthesia; D000777:Anesthetics; D018685:Anesthetics, Inhalation; D002250:Carbon Radioisotopes; D008694:Methamphetamine; D010424:Pentobarbital; D006221:Halothane