title: [Systemic antimicrobial treatment of prosthesis related infections: a comparative study of ornidazole and minocycline. A microbiological evaluation and experimental protocol].
abstract: BACKGROUND
  The aim of this study was to evaluate the efficacy of two chemotherapeutic agents against bacterial forms responsible for prosthesis-related infections.
  
  
  METHODS
  The evaluation was made on the basis of a count using optical microscope 1000x after GRAM staining of the main bacterial forms found in periprosthetic inflammatory exudate both before and after treatment. Two drugs used: ornidazole and minocycline. A group of 20 patients were studied (12 women and 8 men) aged between 42 and 71 years old with an advanced stage of periprosthetic inflammatory pathology. The pharmacological protocol was administered to the two groups of patients for a period of approximately 15 days.
  
  
  RESULTS
  At the end of treatment there was a marked reduction in all the bacterial forms involved in periprosthetic pathology in both groups, with a gradual recovery of normal bacterial flora (gram forms) coupled with a clinical improvement in the implant sites examined.
  
  
  CONCLUSIONS
  Given the specificity of action shown by ornidazole against pathogenic anaerobic, gram-; bacteroides and sporigenic forms, it is recommended for systemic use against prosthesis-related inflammatory disease.
authors.affiliation: Cattedra di Pedodonzia, Università degli Studi, Padova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Stellini
authors.forename: G
authors.initials: G
authors.lastname: Saler
authors.forename: S
authors.initials: S
authors.lastname: Grandesso
authors.forename: P
authors.initials: P
authors.lastname: Pagnacco
authors.forename: S
authors.initials: S
authors.lastname: Mazzoleni
authors.forename: E
authors.initials: E
authors.lastname: Cavaleri
authors.forename: G A
authors.initials: GA
authors.lastname: Favero
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000994:Antitrichomonal Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D009950:Ornidazole / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000994:Antitrichomonal Agents; D009950:Ornidazole; D008911:Minocycline
vernacular_title: La terapia antimicrobic sistemica delle perimplantiti mediante uso comparato di ornidazolo e minociclina. Valutazione microbiologica e protocollo sperimentale.