title: Review of the ICRP tritium and 14C internal dosimetry models and their implementation in the Genmod-PC code.
abstract: Biokinetic models for tritium and 14C compounds, as described by various ICRP publications, have been incorporated into the Genmod-PC internal dosimetry code. This work reviews the models for tritium and 14C labeled compounds that the ICRP has formulated over several decades. The ICRP dosimetry prescribed for hydrogen and carbon radionuclides is fundamentally different from that recommended for other elements in that it is based on retention functions for whole body activity instead of compartmental biokinetic models. The ICRP recommends dosimetric methods for tritium and 14C compounds, ten of which are coded in Genmod-PC as compartmental models, namely, five tritium compounds, e.g., tritiated water, tritium gas, and five 14C compounds, e.g., carbon dioxide, carbon-labeled methane. The values of the Genmod-PC calculated dose coefficients were compared with the ICRP's values. It is shown how the dose coefficients for intakes of tritium and 14C compounds are affected by different interpretations of the methods recommended by the ICRP for two of the three classes of vapors and gases. Some aspects of the ICRP models, such as the percent oxidized, would benefit from reconsideration so as to produce tritium and 14C biokinetics that are less dependent on the radionuclide.
authors.affiliation: Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Ontario. richardsonr@aecl.ca
authors.forename: R B
authors.initials: RB
authors.lastname: Richardson
authors.forename: D W
authors.initials: DW
authors.lastname: Dunford
mesh_terms: D002250:Carbon Radioisotopes / Q000493:pharmacokinetics*; D006801:Humans; D011829:Radiation Dosage; D014316:Tritium / Q000493:pharmacokinetics*
chemical_list: D002250:Carbon Radioisotopes; D014316:Tritium