[Chemokines and defense-system cell homing].
The general properties of chemokines and their receptors are described, and the perspectives raised for cellular therapy are discussed. Specific examples are provided in the cases of the CXC chemokine SDF1 and of chemokines ligands of CCR5.
Galanaud
P
P
Unité INSERM 131 (Cytokines et Immunomodulation) et Institut Paris-Sud Cytokines (IFR 13), 32, rue des Carnets, 92140 Clamart.
Richard
Y
Y
Emilie
D
D
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000502:physiology; D054377:Chemokine CXCL12; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000145:classification / Q000502:physiology*; D019743:Chemokines, CXC / Q000502:physiology; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007107:Immune System / Q000166:cytology*; D007249:Inflammation / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000166:cytology; D019402:Macrophage Inflammatory Proteins / Q000502:physiology; D019713:Receptors, CCR5 / Q000187:drug effects / Q000502:physiology; D019718:Receptors, CXCR4 / Q000187:drug effects / Q000502:physiology; D019707:Receptors, Chemokine / Q000145:classification / Q000187:drug effects / Q000502:physiology*
C515255:CXCL12 protein, human; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D054377:Chemokine CXCL12; D018925:Chemokines; D019743:Chemokines, CXC; D019402:Macrophage Inflammatory Proteins; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D019707:Receptors, Chemokine
Chimiokines et domiciliation des cellules du système de défense.