Fatal hepatitis associated with isoflurane exposure and CYP2A6 autoantibodies.
Martin
J L
JL
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Keegan
M T
MT
Vasdev
G M
GM
Nyberg
S L
SL
Bourdi
M
M
Pohl
L R
LR
Plevak
D J
DJ
D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D001189:Aryl Hydrocarbon Hydroxylases; D001323:Autoantibodies / Q000097:blood*; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology / Q000473:pathology*; D065637:Cytochrome P-450 CYP2A6; D003577:Cytochrome P-450 Enzyme System / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D017809:Fatal Outcome; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000276:immunology*
D018685:Anesthetics, Inhalation; D001323:Autoantibodies; D003577:Cytochrome P-450 Enzyme System; D007530:Isoflurane; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C585710:CYP2A6 protein, human; D065637:Cytochrome P-450 CYP2A6