title: Levodopa induces dyskinesias in normal squirrel monkeys.
abstract: This study assessed whether or not levodopa induces dyskinesias in normal (ie, unlesioned) squirrel monkeys. All six animals treated twice daily with levodopa (15 mg/kg with carbidopa by oral gavage) for two weeks developed choreoathetoid dyskinesias, whereas none of the vehicle-treated animals displayed any abnormal movements. These dyskinesias did not merely reflect a generalized motor activation as locomotion was actually suppressed. The present data demonstrate that preexisting nigrostriatal damage is not necessary for the development of levodopa-induced dyskinesias.
authors.affiliation: The Parkinson's Institute, Sunnyvale, CA 94089, USA. dtogasaki@parkinsonsinstitute.org
authors.forename: D M
authors.initials: DM
authors.lastname: Togasaki
authors.forename: L
authors.initials: L
authors.lastname: Tan
authors.forename: P
authors.initials: P
authors.lastname: Protell
authors.forename: D A
authors.initials: DA
authors.lastname: Di Monte
authors.forename: M
authors.initials: M
authors.lastname: Quik
authors.forename: J W
authors.initials: JW
authors.lastname: Langston
mesh_terms: D000818:Animals; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000503:physiopathology*; D007980:Levodopa / Q000009:adverse effects*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D012016:Reference Values; D012453:Saimiri
chemical_list: D007980:Levodopa