A simple procedure for synthesis of roxindole, a dopamine D2-receptor agonist.
A modified convenient and high yielding synthetic route for the preparation of the dopamine agonist roxindole 1 is described. The key step in our method is the phase-transfer catalyzed reaction of gamma-butyrolactone with 5-methoxyindole which results in the indolylbutyric acid derivative directly in one step.
Csende
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Taxus Pharmaceuticals, H-4440 Tiszavasvári, Vasvári P. u. 61., Hungary. csende@elender.hu
D018491:Dopamine Agonists / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis*; D000078183:Oxindoles; D011725:Pyridines / Q000138:chemical synthesis*; D017448:Receptors, Dopamine D2 / Q000819:agonists*; D013055:Spectrophotometry, Infrared
D018491:Dopamine Agonists; D007202:Indicators and Reagents; D007211:Indoles; D000078183:Oxindoles; D011725:Pyridines; D017448:Receptors, Dopamine D2; C059613:roxindole