Response to cancer therapy in a patient with a paraneoplastic choreiform disorder.
The authors report a patient with chorea and multifocal neurologic abnormalities associated with a small-cell lung carcinoma. A previously unreported antibody directed at a 76-kD neuronal protein antigen was identified in both serum and CSF. Antitumor treatment resulted in dramatic and sustained clinical neurologic and serologic responses.
Croteau
D
D
Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.
Owainati
A
A
Dalmau
J
J
Rogers
L R
LR
D000818:Animals; D018288:Carcinoma, Small Cell / Q000097:blood / Q000134:cerebrospinal fluid / Q000628:therapy*; D002819:Chorea / Q000097:blood / Q000134:cerebrospinal fluid / Q000628:therapy*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000134:cerebrospinal fluid / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000134:cerebrospinal fluid / Q000628:therapy*; D051381:Rats