Induction of micronuclei in mouse polychromatic erythrocytes by the administration of non-radioactive CsCl by the oral and intraperitoneal route.
In the present study, we describe the effects of the concentration and route of administration of non-radioactive cesium chloride (CsCl) in inducing micronuclei in mouse bone marrow polychromatic erythrocytes (PCEs). When the dose of 500mg/kg body weight was administered perorally (p.o.), no significant incidence of micronuclei was detected. However, when the same dose was administered intraperitoneally (i.p.), a significant induction of micronuclei in PCEs was observed compared to control. At the dose of 1000mg/kg, both routes were efficient, with no significant difference in micronucleus frequencies. We conclude that both the p.o. and i.p. routes are efficient in inducing micronuclei, with the i.p. route being more efficient when lower CsCl doses are used.
Santos-Mello
R
R
Laboratório de Mutagênese, Departamento de Ciências Biológicas, Universidade Luterana do Brasil (ULBRA), Rua Miguel Tostes 101, Bairro S. Luís, Prédio 19, Sala 208, 92420-280, RS, Canoas, Brazil. mello@ulbra.br
Deimling
L I
LI
Almeida
A
A
D000284:Administration, Oral; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology; D002586:Cesium / Q000008:administration & dosage / Q000633:toxicity*; D002712:Chlorides / Q000008:administration & dosage / Q000633:toxicity*; D002869:Chromosome Aberrations / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000473:pathology*; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects* / Q000473:pathology*; D015162:Micronucleus Tests; D009153:Mutagens / Q000008:administration & dosage* / Q000633:toxicity*
D002712:Chlorides; D009153:Mutagens; D002586:Cesium; C028019:cesium chloride