Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice.
Both ionotropic and metabotropic glutamate receptors (mGluRs) are involved in the behavioral effects of pyschostimulants; however, the specific contributions of individual mGluR subtypes remain unknown. Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite showing cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA) levels similar to wild-type (WT) mice. These results demonstrate a significant contribution of mGlu5 receptors to the behavioral effects of cocaine, and suggest that they may be involved in cocaine addiction.
Chiamulera
C
C
Department of Biology, GlaxoSmithKline Laboratories, via Fleming 4, 37100 Verona, Italy.
Epping-Jordan
M P
MP
Zocchi
A
A
Marcon
C
C
Cottiny
C
C
Tacconi
S
S
Corsi
M
M
Orzi
F
F
Conquet
F
F
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout / Q000235:genetics; D009043:Motor Activity / Q000187:drug effects*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D012016:Reference Values; D012054:Reinforcement, Psychology; D012646:Self Administration
C578936:Grm5 protein, mouse; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D003042:Cocaine