title: Effects of PCBs on reactive oxygen species (ROS) production by the immune cells of Paracentrotus lividus (Echinodermata).
abstract: The impact of four PCB congeners: 3,3',4,4'-tetrachlorobiphenyl (IUPAC congener #77), 3,3',4,4',5-pentachlorobiphenyl (IUPAC #126), 2,2',4,4',5,5'-hexachlorobiphenyl (IUPAC #153) and 3,3',4,4',5,5'-hexachlorobiphenyl (IUPAC #169) was investigated on the reactive oxygen species (ROS) production by coelomocytes of the echinoid Paracentrotus lividus, an important species in marine benthic ecosystems. PCBs were found to increase ROS production and to delay the time of peak production. These effects were stronger on bacteria-stimulated cells and were congener-specific: coplanar congeners (#77, 126 and 169) had more effect than the non-coplanar PCB #153. Among coplanar congeners, PCB #169 showed dose-dependent effects whereas PCB #77 and 126 were more toxic at high and low doses, respectively. The relative immunotoxicity of the different PCB congeners is discussed in the light of their structural properties and biological affinities.
authors.affiliation: Laboratoire de Biologie Marine, Université Libre de Bruxelles, Brussels, Belgium. gcoteur@ulb.ac.be
authors.forename: G
authors.initials: G
authors.lastname: Coteur
authors.forename: B
authors.initials: B
authors.lastname: Danis
authors.forename: S W
authors.initials: SW
authors.lastname: Fowler
authors.forename: J L
authors.initials: JL
authors.lastname: Teyssié
authors.forename: P
authors.initials: P
authors.lastname: Dubois
authors.forename: M
authors.initials: M
authors.lastname: Warnau
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D008163:Luminescent Measurements; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics / Q000633:toxicity*; D017382:Reactive Oxygen Species / Q000276:immunology / Q000378:metabolism*; D012617:Sea Urchins / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D018675:Toxicity Tests
chemical_list: D017382:Reactive Oxygen Species; D011078:Polychlorinated Biphenyls