[Induction of co-stimulatory molecules on the surface of blast cells in patients with acute myeloid leukemia].
OBJECTIVE
To compare the capacity of ionophore for calcium ions and growth factors (granulocytic-macrophagal colony-stimulating factor, interleukin-4, tumor necrosis factor) to induce costimulatory molecules on the surface of blast cells from patients with acute myeloid leukemia (AML).


METHODS
The study was carried out in 6 patients with primary and resistant AML using culturing and flow cytometry.


RESULTS
Blast cells obtained from patients during diagnosis of AML and after drug therapy of resistant AML acquire the dendrite phenotype under the effects of growth factors and Ca ion ionophore.


CONCLUSIONS
Calcium metabolism modulators can be used for creation of antileukemic vaccines.
Sadovnikova
E Iu
EIu
Strel'nikova
T B
TB
Parovichnikova
E N
EN
Savchenko
V G
VG
D000208:Acute Disease; D000328:Adult; D000938:Antigen-Presenting Cells; D002118:Calcium / Q000494:pharmacology; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D016130:Immunophenotyping; D007167:Immunotherapy; D007476:Ionophores; D007477:Ions; D007951:Leukemia, Myeloid / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
D006133:Growth Substances; D007476:Ionophores; D007477:Ions; D002118:Calcium
Induktsiia kostimuliatornykh molekul na poverkhnosti blastnykh kletok u bol'nykh ostrymi mieloidnymi leĭkozami.