title: Synthesis of the naphthalene portion of the rubromycins.
abstract: [reaction: see text]. A synthesis of a reduced version of the naphthazarin found in the rubromycin class of natural products is reported. The naphthalene ring system is formed via a Dötz reaction with a symmetrical alkyne. Differentiation between the C1' and C3' groups of the Dötz adduct is achieved by selective oxidation since the two methylene groups possess different oxidation potentials.
authors.affiliation: Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: X
authors.initials: X
authors.lastname: Xie
authors.forename: M C
authors.initials: MC
authors.lastname: Kozlowski
mesh_terms: D009281:Naphthalenes / Q000737:chemistry*; D010084:Oxidation-Reduction; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009281:Naphthalenes; D011809:Quinones; C031721:naphthalene