title: Does GnRH analog improve the final height in Thai girls with idiopathic central precocious puberty?
abstract: Ten Thai girls with idiopathic central precocious puberty (ICPP) were treated with gonadotrophin releasing hormone (GnRH) analog for a mean period of 1.5+/-0.4 years. The predicted adult height at the end of treatment was significantly higher than that at the start of treatment (158.2+/-7.9 vs 153.0+/-8.7 cm, p=0.009). In addition, treatment with GnRH analog could significantly regress the breast staging from 3.4+/-0.8 to 2.6+/-1.0 (p=0.04),but not the pubic hair staging. Five of them reached a final height which was not significantly higher than the predicted adult height before treatment (153.1+/-4.8 vs 150.7+/-1.0 cm, p=0.5). In conclusion, treatment with GnRH analog in Thai girls with ICPP can improve the predicted adult height and regress the breast staging. However, the improvement of final height is not promising.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Wacharasindhu
authors.forename: S
authors.initials: S
authors.lastname: Srivuthana
authors.forename: S
authors.initials: S
authors.lastname: Aroonparkmongkol
authors.forename: P
authors.initials: P
authors.lastname: Trinavarat
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001827:Body Height / Q000187:drug effects*; D015992:Body Mass Index; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D006801:Humans; D011237:Predictive Value of Tests; D011336:Probability; D011629:Puberty, Precocious / Q000175:diagnosis / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: C436203:relisorm L; D007987:Gonadotropin-Releasing Hormone