title: Alcoholic liver cirrhosis complicated with torsade de pointes during plasma exchange and hemodiafiltration.
abstract: A 36-year-old man with severe alcoholic hepatitis was treated with plasma exchange combined with hemodiafiltration to remove endotoxins and inflammatory cytokines. During the treatment, he had critical arrhythmia (torsade de pointes [TdP]). His laboratory data showed hypomagnesemia, which was suspected to be responsible for the development of TdP. Patients with alcoholic liver disease tend to have hypomagnesemia and Q-T interval prolongation. Furthermore, hemodiafiltration may cause hypomagnesemia. Careful observation for electrolytic imbalance is necessary when clinicians treat patients with alcoholic liver failure with a liver support system.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakasone
authors.forename: R
authors.initials: R
authors.lastname: Sugama
authors.forename: H
authors.initials: H
authors.lastname: Sakugawa
authors.forename: R
authors.initials: R
authors.lastname: Matayoshi
authors.forename: T
authors.initials: T
authors.lastname: Miyagi
authors.forename: T
authors.initials: T
authors.lastname: Maeshiro
authors.forename: T
authors.initials: T
authors.lastname: Yamashiro
authors.forename: F
authors.initials: F
authors.lastname: Higa
authors.forename: A
authors.initials: A
authors.lastname: Hokama
authors.forename: F
authors.initials: F
authors.lastname: Kinjo
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Toda
mesh_terms: D000328:Adult; D004562:Electrocardiography / Q000379:methods; D017583:Hemodiafiltration / Q000009:adverse effects*; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000150:complications / Q000628:therapy*; D008274:Magnesium / Q000097:blood*; D008297:Male; D010951:Plasma Exchange / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000097:blood / Q000175:diagnosis / Q000209:etiology*
chemical_list: D008274:Magnesium