title: Parallel solid-phase synthesis of nucleoside phosphoramidate libraries.
abstract: Combinatorial chemistry is playing an increasingly prominent role in the process of drug discovery. A nucleic acid-based (NAB) scaffold can be engineered to create functional group and topological diversity in a library. Described herein is the parallel solid-phase synthesis of combinatorial libraries of nucleoside phosphoramidates, and the first evaluation of antiviral activity against hepatitis B virus (HBV).
authors.affiliation: Origenix Technologies Inc., 230 Bernard-Belleau, Suite 210, Laval, H7V 4A9, Québec, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Côté
authors.forename: A
authors.initials: A
authors.lastname: Roland
authors.forename: B
authors.initials: B
authors.lastname: Korba
authors.forename: S
authors.initials: S
authors.lastname: Mounir
authors.forename: R P
authors.initials: RP
authors.lastname: Iyer
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006515:Hepatitis B virus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000577:Amides; D000998:Antiviral Agents; D009711:Nucleotides; D010756:Phosphoric Acids; C011067:phosphoramidic acid