[Intracellular signal transduction mediated via 5-HT and NA receptors].
The present brief review was discussed about the intracellular signal transduction mediated via 5-HT and NA receptors focussing on the mechanism of antidepressants. Recent studies demonstrated that long-term antidepressant treatments resulted in activation of cAMP pathway at several levels including CREB(cAMP response element-binding protein) and BDNF(brain-derived neurotrophic factor). These pathways are elevated via 5-HT and/or NA receptors which directly couple to the cAMP system(5-HT4,6,7 receptors or beta adrenoceptors), or via receptors that lead to activation of Ca(2+)-dependent protein kinase(5-HT2 receptors or alpha 1 adrenoceptors). Such factors could be common targets for many different type of antidepressants. Elucidation of the signal transduction mediated via 5-HT and/or NA receptors, therefore, provide significant information understanding the pathophysiology of depression.
Matsumoto
M
M
Department of Pharmacology, Hokkaido University School of Medicine.
Yoshioka
M
M
D000818:Animals; D006801:Humans; D020239:Receptor Cross-Talk; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D018341:Receptors, Adrenergic, alpha-2; D011985:Receptors, Serotonin