title: The role of dopamine in the timing of Pavlovian conditioned keypecking in ring doves.
abstract: The effect of dopaminergic drugs on the timing of conditioned keypecking in ring doves was studied in two experiments. Subjects were given pairings of a keylight with food and the temporal distribution of keypecks was obtained during unreinforced probe trials. Experiment 1 demonstrated that injections of pimozide before each session immediately decreased response rates but shifted timing distributions gradually to the right over several days of treatment. Experiment 2 showed similar results using a longer interstimulus interval (ISI). No shifts were observed when the drug was injected after training sessions, or when a delay, identical to each subject's average latency to eat during the drug condition, was inserted between keylight offset and food presentation. Consequently, the shifts in timing were mediated neither by mere accumulation of the drug nor a delay from keylight offset to food presentation resulting from the drug's ability to slow motor processes. The results suggest that pimozide modulates response rate through its effect on motor processes or incentive value, and response timing through a conditioned response (CR) to injection-related cues established via their repeated pairings with the drug.
authors.affiliation: Department of Psychology, Columbia University in the City of New York, 406 Schermerhorn Hall, New York, NY 10027, USA. tatsuya.ohyama@uth.tmc.edu
authors.forename: T
authors.initials: T
authors.lastname: Ohyama
authors.forename: J C
authors.initials: JC
authors.lastname: Horvitz
authors.forename: E
authors.initials: E
authors.lastname: Kitsos
authors.forename: P D
authors.initials: PD
authors.lastname: Balsam
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001717:Birds; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
chemical_list: D018492:Dopamine Antagonists; D018765:Dopamine Uptake Inhibitors; D010868:Pimozide; D000661:Amphetamine