title: The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism.
abstract: We have previously reported that MCI-225, a selective noradrenaline (NA) reuptake inhibitor with serotonin (5-HT)3 receptor antagonism, shows antidepressant-like properties in experiments using rodents. In this study, we investigated the effect of MCI-225 in anxiety models in comparison with diazepam, ondansetron, maprotiline, imipramine, and trazodone. In social interaction (SI) test in rats, MCI-225 (10 and 30 mg/kg, p.o.), diazepam (1-10 mg/kg, p.o.), and a selective 5-HT3 receptor antagonist ondansetron (1 mg/kg, p.o.) significantly increas
authors.affiliation: Pharmaceuticals Research Laboratory I, Yokohama Research Center Mitsubishi-Tokyo Pharmaceuticals, Inc., Yokohama, Japan. 1307265@mitsubishi-pharm.co.jp
authors.forename: J
authors.initials: J
authors.lastname: Eguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Inomata
authors.forename: K
authors.initials: K
authors.lastname: Saito
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000627:therapeutic use*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy*; D001645:Biguanides / Q000627:therapeutic use; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D017294:Ondansetron / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000502:physiology; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use
chemical_list: D018759:Adrenergic Uptake Inhibitors; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001645:Biguanides; D010879:Piperazines; D011619:Psychotropic Drugs; D011743:Pyrimidines; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C085298:MCI 225; D017294:Ondansetron; C065734:1-(3-chlorophenyl)biguanide; D009638:Norepinephrine