title: Endonasal endoscopic removal of growth-hormone-secreting pituitary adenomas.
abstract: Trans-sphenoidal removal of pituitary tumours using the endonasal endoscopic technique, a novel application, is herein reported in five consecutive patients with growth-hormone-secreting pituitary adenomas seen at a teaching hospital in Hong Kong. All five patients demonstrated complete tumour removal on postoperative imaging and hormonal assessment following the procedure. Surgical morbidity and symptoms were minimal; postoperative obstructive nasal packing was not required with this technique, which greatly improved patient comfort. Preliminary experience suggests that the endonasal endoscopic approach is a safe and effective alternative to the conventional trans-septal microscopic method for the treatment of pituitary tumour. A randomised controlled trial comparing these two approaches is currently underway at this institution.
authors.affiliation: Division of Neurosurgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
authors.forename: W M
authors.initials: WM
authors.lastname: Lui
authors.forename: G K
authors.initials: GK
authors.lastname: Leung
authors.forename: Y
authors.initials: Y
authors.lastname: Hui
authors.forename: K K
authors.initials: KK
authors.lastname: Lee
authors.forename: Y W
authors.initials: YW
authors.lastname: Fan
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000601:surgery*; D000328:Adult; D004724:Endoscopy; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000601:surgery*; D013100:Sphenoid Bone
chemical_list: D019382:Human Growth Hormone