title: Comparative genomic hybridization reveals non-random chromosomal aberrations in early preinvasive cervical lesions.
abstract: We performed CGH analysis on 34 cervical lesions, which included 8 cases of koilocytosis, 6 mild dysplasias and 20 moderate dysplasias. Chromosome aberrations were detected in 11 cases of which 9 were moderate dysplasias. A total of 55 chromosome arms were involved. The most frequent aberrations were losses of 5p and Xq, each of which was present in 5/34 cases. Gain of 3q was detected in two moderate dysplasias. This aberration is the most frequent copy number change in advanced-stage cervical carcinoma. A considerable number of the aberrations found in the preinvasive cases of this study are frequently present in invasive cervical tumors. The presence of apparently non-random chromosome aberrations in early preinvasive cervical lesions has not previously been described.
authors.affiliation: Cytogenetic Laboratory, Department of Clinical Genetics, Juliane Marie Center, The National University Hospital, Copenhagen, Denmark. markir@rh.dk
authors.forename: M
authors.initials: M
authors.lastname: Kirchhoff
authors.forename: H
authors.initials: H
authors.lastname: Rose
authors.forename: B L
authors.initials: BL
authors.lastname: Petersen
authors.forename: J
authors.initials: J
authors.lastname: Maahr
authors.forename: T
authors.initials: T
authors.lastname: Gerdes
authors.forename: J
authors.initials: J
authors.lastname: Philip
authors.forename: C
authors.initials: C
authors.lastname: Lundsteen
mesh_terms: D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D018628:Gene Dosage; D006801:Humans; D002578:Uterine Cervical Dysplasia / Q000235:genetics*