title: Synthesis of novel derivatives of 1,4,7-triazacyclononane.
abstract: [structure: see text]. The coordination environment of 1,4,7-triazacyclononane can be adapted, through sequential functionalization of two secondary amines, to generate ligands applicable in biomimetic studies. Two "amino acids" and an amino derivative have been prepared from 1,4,7-triazatricyclo[5.2.1.0(4,10)]decane. This synthon allows efficient attachment of one functional group to the macrocyclic ring, forming a monoamidinium salt. Hydrolysis generates a formyl derivative, which was further functionalized at the secondary amine and hydrolyzed in strong acid to generate ligands 1-3.
authors.affiliation: Department of Chemistry, Monash University, 3800 Victoria, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Warden
authors.forename: B
authors.initials: B
authors.lastname: Graham
authors.forename: M T
authors.initials: MT
authors.lastname: Hearn
authors.forename: L
authors.initials: L
authors.lastname: Spiccia