FK506 facilitates chemical kindling induced by pentylenetetrazole in rats.
To clarify the possible role played by calcineurin in kindling development, we examined the effects of pretreatment with FK506, a selective calcineurin inhibitor, on pentylenetetrazole (PTZ) kindling in rats. FK506 facilitated the speed of kindling induced by repeated administration of 30-mg/kg PTZ, while FK506 did not ameliorate acute seizure manifestations after a single injection of PTZ. Our results suggested that calcineurin might exert an inhibitory effect on PTZ kindling.
Suzuki
K
K
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 20-1 Handayama 1-chome, Hamamatsu, Shizuoka 431-3192, Japan.
Omura
S
S
Ohashi
Y
Y
Kawai
M
M
Iwata
Y
Y
Tani
K
K
Sekine
Y
Y
Takei
N
N
Mori
N
N
D000818:Animals; D065095:Calcineurin Inhibitors; D003292:Convulsants; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D016559:Tacrolimus / Q000494:pharmacology*
D065095:Calcineurin Inhibitors; D003292:Convulsants; D007166:Immunosuppressive Agents; D016559:Tacrolimus; D010433:Pentylenetetrazole