title: Genetic variability following selection of Haemonchus contortus with anthelmintics.
abstract: Genetic diversity in nematodes leads to variation in response to anthelmintics. Haemonchus contortus shows enormous genetic diversity, allowing anthelmintic resistance alleles to be rapidly selected. Anthelmintic resistance is now a widespread problem, especially in H. contortus. Here, I compare the genes involved in anthelmintic resistance in H. contortus with those that confer susceptibility or resistance on the free living nematode Caenorhabditis elegans. I also discuss the latest knowledge of genes associated with resistance to benzimidazoles, levamisole and the macrocyclic lactones and the need for DNA markers for anthelmintic resistance.
authors.affiliation: Institute of Parasitology, McGill University, H9X 3V9, Montreal, Canada. roger.prichard@mcgill.ca
authors.forename: R
authors.initials: R
authors.lastname: Prichard
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D004351:Drug Resistance / Q000235:genetics; D014644:Genetic Variation; D006189:Haemonchus / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D012641:Selection, Genetic
chemical_list: D000969:Antinematodal Agents