Nuclear matrix protein (NMP) levels in patients with acute pancreatitis.
Nuclear matrix protein (NMP) is an index of apoptosis. We measured NMP in 22 patients with acute pancreatitis and investigated the relationship between severity and NMP. We also measured tumor necrosis factor-alpha (TNF-alpha) and investigated the relationship between NMP and TNF-alpha. The NMP value increased significantly as the pancreatitis became more increasingly severe, and the NMP values were significantly higher in the group with multiple organ dysfunction syndrome (MODS) than in the group without MODS. A comparison of the NMP values in the group that survived and the group that died revealed higher NMP values in the former. A significant correlation was found between the NMP values and the TNF-alpha values, suggesting that apoptosis may contribute to the pathophysiology of acute pancreatitis.
Endo
S
S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan. sendo@iwate.med.ac.jp
Inada
K
K
Inoue
Y
Y
Yamada
Y
Y
Fujino
Y
Y
Miura
M
M
Baba
E
E
Sato
N
N
Wakabayashi
G
G
Katsuya
H
H
Sato
S
S
D000208:Acute Disease; D000328:Adult; D000368:Aged; D034961:Antigens, Nuclear; D017209:Apoptosis / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000378:metabolism; D009687:Nuclear Proteins / Q000097:blood / Q000378:metabolism*; D010195:Pancreatitis / Q000378:metabolism*; D013223:Statistics as Topic; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D034961:Antigens, Nuclear; D009687:Nuclear Proteins; D014409:Tumor Necrosis Factor-alpha