title: Tics and its disorders.
abstract: Tourette syndrome (TS) is familial neuropsychiatric disorder that is characterized by motor and phonic tics that begin in childhood. Once thought of as a rare and debilitating disorder, in the last decade new scientific knowledge suggests that TS and related tic disorders are more common and less debilitating for the majority of individuals. Evidence points toward a spectrum of TS symptomatology that extends beyond the tics disorder to probably include obsessive-compulsive disorder, attention deficit hyperactivity disorder, and mood disorders. Tourette syndrome and its differential diagnosis are discussed in this article with a focus on new developments in classification, etiology, epidemiology, genetics, pathophysiology, and clinical management.
authors.affiliation: Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642-8673, USA.
authors.forename: D
authors.initials: D
authors.lastname: Marcus
authors.forename: R
authors.initials: R
authors.lastname: Kurlan
mesh_terms: D015897:Comorbidity; D003937:Diagnosis, Differential; D006801:Humans; D013981:Tic Disorders / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D005879:Tourette Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology