title: The influence of lidocaine on the permeability of the blood-cerebrospinal fluid barrier in experimental acute hypercapnia in the rabbit.
abstract: In a previous study we have provided evidence, that acute experimental hypercapnia due to hypoventilation in the rabbit alters blood-cerebrospinal fluid barrier function in the brain (Pakulski et al. 1998). The purpose of this study therefore was to determine if lidocaine would prevent the observed alterations in the blood-cerebrospinal fluid barrier function. The experiments were conducted in 16 adult Chinchilla rabbits submitted to acute hypercapnia due to mechanical hypoventilation (PaCO2 between 8-9.5 kPa over 180 minutes) under pentobarbital anaesthesia. The studied group (n = 8) was treated by lidocaine infusion 10 mg kg-1 h-1. After 180 minutes of hypercapnia the value of cerebrospinal fluid-blood index of gentamycin concentration, indicating the permeability of the blood-cerebrospinal fluid barrier, was significantly lower in animals treated with lidocaine (4.03 +/- 2.32 vs. 19.05 +/- 5.49; P < 0.01). We conclude that lidocaine may attenuate the increase of blood-cerebrospinal fluid barrier permeability under conditions of experimental acute hypercapnia lasting 180 minutes in the mechanically ventilated rabbit.
authors.affiliation: Experimental Anaesthesia Department, Institute of Anaesthesiology and Intensive Therapy, K. Marcinkowski Medical University, 14 św. Marii Magdaleny St., 61-861 Poznań, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Naskret
authors.forename: M
authors.initials: M
authors.lastname: Płatkiewicz
authors.forename: H
authors.initials: H
authors.lastname: Billert
authors.forename: L
authors.initials: L
authors.lastname: Drobnik
authors.forename: S
authors.initials: S
authors.lastname: Dyderski
mesh_terms: D000208:Acute Disease; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics; D001794:Blood Pressure; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005839:Gentamicins / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics; D006339:Heart Rate; D006935:Hypercapnia / Q000188:drug therapy* / Q000503:physiopathology; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D012121:Respiration, Artificial
chemical_list: D000779:Anesthetics, Local; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D008012:Lidocaine