title: Absolute stereostructures of novel norcadinane- and trinoreudesmane-type sesquiterpenes with nitric oxide production inhibitory activity from Alpinia oxyphylla.
abstract: Novel 14-norcadinane-type sesquiterpenes, oxyphyllenodiols A and B, and 11,12,13-trinoreudesmane-type sesquiterpenes, oxyphyllenones A and B, were isolated from the methanolic extract of kernels of Alpinia oxyphylla. The absolute stereostructures of these norsesquiterpenes were determined on the basis of physicochemical and chemical evidence. In addition, oxyphyllenodiol A and oxyphyllenone A were found to inhibit the NO production in lipopolysaccharide-activated macrophages.
authors.affiliation: School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashiosaka, 577-8502, Osaka, Japan. muraoka@phar.kindai.ac.jp
authors.forename: O
authors.initials: O
authors.lastname: Muraoka
authors.forename: M
authors.initials: M
authors.lastname: Fujimoto
authors.forename: G
authors.initials: G
authors.lastname: Tanabe
authors.forename: M
authors.initials: M
authors.lastname: Kubo
authors.forename: T
authors.initials: T
authors.lastname: Minematsu
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Morikawa
authors.forename: I
authors.initials: I
authors.lastname: Toguchida
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D008070:Lipopolysaccharides; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D019862:Zingiberales / Q000737:chemistry*
chemical_list: D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C435684:oxyphyllenodiol A; C435685:oxyphyllenone A; D009569:Nitric Oxide