title: [Clinical and pathogenetic features of CNS damage in children with diphtheria].
abstract: The paper presents clinical and neurological features of diphtheritic polyneuropathy in 110 patients aged from 6 months to 14 years. The pattern of neurological complications appeared to be quite different for nontoxic and toxic forms; electroneuromyographical criteria of preclinical diagnosis of nervous disorders were determined. The role of a vascular factor in demyelinating process' genesis, immunohomeostasis implications in severity and outcomes of diphtheritic polyneuropathies, prognostic factors of the unfavorable course of the disease were defined. Scientifically grounded differential approaches to therapy were presented including application of vasoactive neurometabolites optimizing the processes of sanogenesis.
authors.forename: N V
authors.initials: NV
authors.lastname: Skripchenko
authors.forename: M N
authors.initials: MN
authors.lastname: Sorokina
authors.forename: V N
authors.initials: VN
authors.lastname: Komantsev
authors.forename: A V
authors.initials: AV
authors.lastname: Mel'nikova
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000150:complications* / Q000276:immunology; D004569:Electroencephalography; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D007223:Infant; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000276:immunology; D014786:Vision Disorders / Q000453:epidemiology / Q000209:etiology
chemical_list: D015703:Antigens, CD; D007075:Immunoglobulin M
vernacular_title: Kliniko-patogeneticheskie osobennosti porazheniia nervnoĭ sistemy pri difteriĭnoĭ infektsii u deteĭ.