title: Ethanol-related adaptive changes and physical dependence in rats after exposure to ethanol.
abstract: Adaptive changes that occur after chronic exposure to ethanol are an important component in the development of physical dependence. We have focused our research on ethanol-induced changes in the expression of several genes that may be important in adaptation. In this article, we describe adaptive changes at the level of the N-methyl-D-aspartate receptor, in the protein expression and activity of the Egr transcription factors, and in the expression of a novel gene of unknown function.
authors.affiliation: Alcohol Research Unit, Department of Biochemistry, The University of Queensland, St. Lucia, Queensland, Australia 4072. wilce@biosci.uq.edu.au
authors.forename: P A
authors.initials: PA
authors.lastname: Wilce
authors.forename: I
authors.initials: I
authors.lastname: Depaz
authors.forename: P
authors.initials: P
authors.lastname: Hardy
authors.forename: M
authors.initials: M
authors.lastname: Davidson
authors.forename: V
authors.initials: V
authors.lastname: Jaquet
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000437:Alcoholism / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology; D051766:Early Growth Response Protein 1; D051767:Early Growth Response Protein 2; D000431:Ethanol / Q000494:pharmacology*; D015870:Gene Expression; D017874:Immediate-Early Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics; D020033:Protein Isoforms / Q000378:metabolism; D051381:Rats / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; D051767:Early Growth Response Protein 2; C486110:Egr1 protein, rat; C497328:Egr2 protein, rat; D017874:Immediate-Early Proteins; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D016194:Receptors, N-Methyl-D-Aspartate; C486029:Tagln3 protein, rat; D014157:Transcription Factors; D000431:Ethanol