title: Pro-atrial natriuretic peptide hormone from right atria is correlated with cardiac depression in septic patients.
abstract: N-terminal pro-atrial natriuretic peptide [proANP(1-98)] has been extensively investigated in patients with chronic heart failure and ishemic heart disease. It is found to be a better marker of cardiac dysfunction than atrial natriuretic peptide (ANP). The possible involvement of proANP(1-98) in cardiac depression caused by sepsis has not been studied yet. Therefore, we analyzed atrial plasma concentration of proANP(1-98) in 17 septic patients with hemodynamic variables measured or calculated using pulmonary artery catheter. The results of altogether 96 measurements show a significant negative correlation of proANP(1-98) and cardiac index (p<0.024), oxygen delivery (p<0.03) and oxygen consumption (p<0.03). There is also a positive correlation with pulmonary vascular resistance (p<0.03). ProANP(1-98) is significantly higher in patients who developed acute respiratory distress syndrome (ARDS) (p<0.001). This study implies that proANP(1-98) is a possible novel hormone marker of cardiac depression caused by sepsis that could be used for prediction of ARDS.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, University Hospital Sestre Milosrdnice, Zagreb, Croatia. brankas@phy.hr
authors.forename: B
authors.initials: B
authors.lastname: Mazul-Sunko
authors.forename: N
authors.initials: N
authors.lastname: Zarkovic
authors.forename: N
authors.initials: N
authors.lastname: Vrkic
authors.forename: R
authors.initials: R
authors.lastname: Klinger
authors.forename: M
authors.initials: M
authors.lastname: Peric
authors.forename: M
authors.initials: M
authors.lastname: Bekavac-Beslin
authors.forename: M
authors.initials: M
authors.lastname: Novkoski
authors.forename: A
authors.initials: A
authors.lastname: Krizmanic
authors.forename: A
authors.initials: A
authors.lastname: Gvozdenovic
authors.forename: E
authors.initials: E
authors.lastname: Topic
mesh_terms: D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D011652:Pulmonary Circulation / Q000502:physiology; D013815:Thermodilution; D016278:Ventricular Function, Right / Q000502:physiology