Comparison of 2 techniques for regional antibiotic delivery to the equine forelimb: intraosseous perfusion vs. intravenous perfusion.
The purpose of this study was to compare the synovial fluid concentrations and pharmacokinetics of amikacin in the equine limb distal to the carpus following intraosseous and intravenous regional perfusion. The front limbs of 6 horses were randomly assigned to either intraosseous or intravenous perfusion. A tourniquet was placed distal to each carpus and the limb perfused with 500 mg of amikacin. Systemic blood samples and synovial fluid samples were collected over 70 min from the distal interphalangeal (DIP) joint, metacarpophalangeal joint, and digital flexor sheath. The tourniquet was removed following the 30 min sample collection. The mean peak amikacin concentration for the DIP joint was significantly higher with intravenous perfusion. There were no significant differences in time to peak concentration or elimination half-life between methods at each synovial structure. Each technique produced mean peak concentrations ranging from 5 to 50 times that of recommended peak serum concentrations for therapeutic efficacy.
Butt
T D
TD
Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
Bailey
J V
JV
Dowling
P M
PM
Fretz
P B
PB
D000583:Amikacin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods / Q000662:veterinary; D018592:Cross-Over Studies; D005260:Female; D005552:Forelimb; D006736:Horses / Q000378:metabolism*; D017148:Infusions, Intraosseous / Q000379:methods / Q000662:veterinary; D007262:Infusions, Intravenous / Q000379:methods / Q000662:veterinary; D008297:Male; D013582:Synovial Fluid / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000583:Amikacin