title: Perfusion and diffusion magnetic resonance imaging in human cerebral venous thrombosis.
abstract: BACKGROUND
  Diagnosis of cerebral venous thrombosis (CVT) is usually achieved by digital subtraction angiography or magnetic resonance angiography, while structural brain tissue damage can be assessed by computed tomography or magnetic resonance imaging (MRI). Using perfusion and diffusion weighted imaging (PWI, DWI) we aimed in this study to identify pathophysiological patterns corresponding to only functional and hence reversible tissue involvement.
  
  
  METHODS
  PWI, DWI, and conventional MRI were performed in six CVT patients acutely and after 16-26 days when their clinical condition had improved. All patients were treated with partial thromboplastin time-effective intravenous heparin. After intravenous administration of a paramagnetic contrast agent, bolus track PWI allows pixel based determination of mean transit time (MTT) and cerebral blood volume (CBV). DWI was performed with two different b values (0, 1000 s/mm2) for calculation of apparent diffusion coefficient (ADC) maps.
  
  
  RESULTS
  In five of six cases increased MTT values were observed initially, whereas the CBV was normal, indicating a reduction of cerebral blood flow. ADC values were normal. On follow up after clinical recovery MTT prolongations had resolved. Areas with prolonged MTT did not evolve into structural lesions.
  
  
  CONCLUSIONS
  In patients with CVT, prolongations of MTT in the absence of changes in CBV and ADC seem to indicate reversible involvement of brain tissue, a situation corresponding to the ischaemic penumbra.
authors.affiliation: Klinik und Poliklinik für Neurologie, Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin, Germany. claudia.doege@charite.de
authors.forename: C A
authors.initials: CA
authors.lastname: Doege
authors.forename: R
authors.initials: R
authors.lastname: Tavakolian
authors.forename: C M
authors.initials: CM
authors.lastname: Kerskens
authors.forename: B I
authors.initials: BI
authors.lastname: Romero
authors.forename: R
authors.initials: R
authors.lastname: Lehmann
authors.forename: K M
authors.initials: KM
authors.lastname: Einhäupl
authors.forename: A
authors.initials: A
authors.lastname: Villringer
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002545:Brain Ischemia; D002540:Cerebral Cortex / Q000098:blood supply; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D020767:Intracranial Thrombosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D020246:Venous Thrombosis / Q000473:pathology*
chemical_list: D000925:Anticoagulants; D006493:Heparin