[Effects of inhibitors of angiotensin-converting enzyme combined with antagonists of angiotensin II receptors on endothelial function in patients with chronic cardiac insufficiency].
Effects were studied of a combined therapy with inhibitors of the angiotensin-converting enzyme and antagonists of receptors to angiotensin II on the functional condition of the endothelium in patients with chronic cardiac insufficiency (CCI). Recordable in the study was a noticeable decrease in the level of endothelin-1 and higher values for the concentration of 6-keto-prostaglandin (PGF1 alpha) and cGMP. In that way, administration of inhibitors of the angiotensin-converting enzyme combined with antagonists of receptors to angiotensin II has, been shown to considerably improve the endothelial function in CCi patients, which fact will, we believe, help in raising clinical effectiveness of the above combined medication.
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D000328:Adult; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000378:metabolism / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000627:therapeutic use; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D019332:Endothelin-1 / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D000077405:Irbesartan; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013777:Tetrazoles / Q000627:therapeutic use
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001713:Biphenyl Compounds; D019332:Endothelin-1; D013777:Tetrazoles; D000804:Angiotensin II; D000077405:Irbesartan; D019808:Losartan
Vliianye ingibitorov angiotenzinprevrashchaiushchego fermenta v sochetanii s antagonistami retseptorov angiotenzina II na funktsional'noe sostoianie endoteliia u bol'nykh s khronicheskoĭ serdechnoĭ nedostatochnost'iu.