title: The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.
abstract: A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and TACE were identified, including the potent, orally active MMP-13 inhibitor 4p.
authors.affiliation: Wyeth-Ayerst Research, 401 N. Middletown Rd., Pearl River, NY 10965, USA. levinji@war.wyeth.com
authors.forename: J I
authors.initials: JI
authors.lastname: Levin
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Du
authors.forename: M
authors.initials: M
authors.lastname: Hogan
authors.forename: S
authors.initials: S
authors.lastname: Kincaid
authors.forename: F C
authors.initials: FC
authors.lastname: Nelson
authors.forename: A M
authors.initials: AM
authors.lastname: Venkatesan
authors.forename: T
authors.initials: T
authors.lastname: Wehr
authors.forename: A
authors.initials: A
authors.lastname: Zask
authors.forename: J
authors.initials: J
authors.lastname: DiJoseph
authors.forename: L M
authors.initials: LM
authors.lastname: Killar
authors.forename: S
authors.initials: S
authors.lastname: Skala
authors.forename: A
authors.initials: A
authors.lastname: Sung
authors.forename: M
authors.initials: M
authors.lastname: Sharr
authors.forename: C
authors.initials: C
authors.lastname: Roth
authors.forename: G
authors.initials: G
authors.lastname: Jin
authors.forename: R
authors.initials: R
authors.lastname: Cowling
authors.forename: K M
authors.initials: KM
authors.lastname: Mohler
authors.forename: R A
authors.initials: RA
authors.lastname: Black
authors.forename: C J
authors.initials: CJ
authors.lastname: March
authors.forename: J S
authors.initials: JS
authors.lastname: Skotnicki
mesh_terms: D051722:ADAM Proteins; D000072198:ADAM17 Protein; D017364:Collagenases / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D053509:Matrix Metalloproteinase 13; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D062367:ortho-Aminobenzoates; D051722:ADAM Proteins; D017364:Collagenases; D053509:Matrix Metalloproteinase 13; D020782:Matrix Metalloproteinases; D008666:Metalloendopeptidases; D020780:Matrix Metalloproteinase 9; D000072198:ADAM17 Protein