title: Effect of fasciolicides on the antigenaemia in sheep naturally infected with Fasciola hepatica.
abstract: A study was developed to evaluate the influence of triclabendazole (Fasinex) and netobimin (Hapasil) the antigenaemia in sheep naturally infected with Fasciola hepatica during 16 weeks. A sandwich-ELISA (enzyme-linked immunosorbent assay) using a rabbit polyclonal IgG antibody to F. hepatica antigens was employed and the data obtained were compared to those from coprological and indirect-ELISA techniques. Triclabendazole reduced the values of circulating antigens at weeks 2-4 post-treatment and faecal output at weeks 2-8 post-treatment, but antibodies showed positive values until the end of the study. Netobimin did not reduce circulating antigens of the trematode nor egg-excretion; and IgG antibodies did not decrease throughout the study.
authors.affiliation: Departamento de Patología Animal, Parasitología y Enfermedades Parasitarias, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Sánchez-Andrade
authors.forename: A
authors.initials: A
authors.lastname: Paz-Silva
authors.forename: J L
authors.initials: JL
authors.lastname: Suárez
authors.forename: R
authors.initials: R
authors.lastname: Panadero
authors.forename: J
authors.initials: J
authors.lastname: Pedreira
authors.forename: P
authors.initials: P
authors.lastname: Díez-Baños
authors.forename: P
authors.initials: P
authors.lastname: Morrondo
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000909:Antibodies, Helminth / Q000276:immunology; D000947:Antigens, Helminth / Q000097:blood*; D001562:Benzimidazoles / Q000627:therapeutic use*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D010270:Parasite Egg Count; D018512:Parasitemia / Q000188:drug therapy / Q000469:parasitology; D012680:Sensitivity and Specificity; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D001562:Benzimidazoles; D006146:Guanidines; D000077682:Triclabendazole; C049626:netobimin