title: Predicted amino acid sequences for 100 JCV strains.
abstract: DNA sequence variation between JCV genotypes is confined largely to noncoding intergenic regions and introns. Nevertheless, evidence suggests that the amino acid sequence variations among the 8 genotypes of JCV can influence the potential for neurovirulence of the virus. In the current study, the amino acid sequences for 100 JCV genomes were translated and grouped into genotype families. Subtype consensus sequences were determined and the type-specific amino acid sequence variants were identified.
authors.affiliation: Neurotoxicology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Cubitt
authors.forename: X
authors.initials: X
authors.lastname: Cui
authors.forename: H T
authors.initials: HT
authors.lastname: Agostini
authors.forename: V R
authors.initials: VR
authors.lastname: Nerurkar
authors.forename: I
authors.initials: I
authors.lastname: Scheirich
authors.forename: R
authors.initials: R
authors.lastname: Yanagihara
authors.forename: C F
authors.initials: CF
authors.lastname: Ryschkewitsch
authors.forename: G L
authors.initials: GL
authors.lastname: Stoner
mesh_terms: D000595:Amino Acid Sequence; D000957:Antigens, Viral, Tumor / Q000235:genetics; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D005838:Genotype; D007577:JC Virus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D008969:Molecular Sequence Data; D014764:Viral Proteins / Q000235:genetics; D054334:Viral Regulatory and Accessory Proteins; D014774:Virulence; D000086082:Viroporin Proteins
chemical_list: D000957:Antigens, Viral, Tumor; D036022:Capsid Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C062481:VP1 protein, polyomavirus; C042559:agnoprotein, polyomavirus; D000086082:Viroporin Proteins