Processing and presentation of antigens by dendritic cells: implications for vaccines.
Dendritic cells (DCs) are potent antigen-presenting cells that are specialized in initiation of T-cell immunity. DCs induce promising anti-tumor T-cell and clinical responses, apparently without significant toxicity. Under certain conditions, DCs even silence T-cell immune responses in vivo. This dual capacity to modulate the immune system uniquely positions DCs for the treatment of autoimmunity, cancer and chronic viral infections.
Bhardwaj
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The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. bhardwn@rockvax.rockefeller.edu
D000276:Adjuvants, Immunologic; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007694:Killer Cells, Natural / Q000276:immunology; D018448:Models, Immunological; D014612:Vaccines / Q000009:adverse effects / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000941:Antigens; D014612:Vaccines