title: Emotional and behavioral symptoms in children with acute leukemia.
abstract: OBJECTIVE
  The diagnosis of leukemia is probably one of the most severe stressors that children can experience and may be associated with emotional and behavioral symptoms indicating comorbidity with mental health disorders. This study aims to evaluate the presence of emotional and behavioral symptoms in children with acute leukemia exposed to chemotherapy from outpatient services at two university hospitals in Brazil.
  
  
  METHODS
  In this cross-sectional study, emotional and behavioral symptoms were assessed using the Children Behavior Checklist (CBCL) in three groups of children aged 5-14 years: a) children with acute leukemia (n = 21); b) children with blood dyscrasias (n = 21); c) children evaluated or treated in a pediatric outpatient service (n = 33).
  
  
  RESULTS
  Children with blood dyscrasias had significantly few symptoms of externalization (delinquent and aggressive behavior) than pediatric controls (p< 0.05). Children with leukemia did not differ from the two other groups regarding symptoms of externalization. No significant difference on the scores of the CBCL internalization dimension (anxiety, depression, somatic symptoms and withdrawn) was found among the three groups.
  
  
  CONCLUSIONS
  These findings seem to indicate that children with acute leukemia do not have more emotional or behavioral symptoms than children with benign hematologic or physical diseases suggesting that comorbidity with mental disorders is not higher in children with acute leukemia than in children in the other two groups.
authors.affiliation: Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Michalowski
authors.forename: C
authors.initials: C
authors.lastname: Ketzer
authors.forename: L
authors.initials: L
authors.lastname: Daudt
authors.forename: L A
authors.initials: LA
authors.lastname: Rohde
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000342:Affective Symptoms / Q000175:diagnosis / Q000209:etiology; D001526:Behavioral Symptoms / Q000175:diagnosis / Q000209:etiology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000523:psychology*; D008297:Male