title: Therapy-related refractory anemia with ringed sideroblasts in chronic lymphocytic leukemia. involvement of 3q21 region.
abstract: Therapy-related myelodysplastic syndrome/acute myelogenous leukemia (t-MDS/AML) is extremely rare in chronic lymphocytic leukemia (CLL) despite extensive use of alkylating agents. We present a case of heavily treated CLL with resultant therapy-related refractory anemia with ringed sideroblasts (RARS). A complex cytogenetic abnormality including involvement of 3q21 was detected and to our knowledge, is the first report of a RARS case with a 3q21 abnormality.
authors.affiliation: Department of Hematology, Gazi University Medical School, Oyak sitesi 21, Cankaya Ankara, Turkey. erhem@med.gazi.edu.tr
authors.forename: M
authors.initials: M
authors.lastname: Yağci
authors.forename: G T
authors.initials: GT
authors.lastname: Sucak
authors.forename: G
authors.initials: G
authors.lastname: Oğur
authors.forename: R
authors.initials: R
authors.lastname: Haznedar
mesh_terms: D000753:Anemia, Refractory / Q000235:genetics*; D002869:Chromosome Aberrations; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics*