title: Pneumonitis induced by ou-gon (scullcap).
abstract: A 53-year-old Japanese man with recurrent interstitial pneumonia was referred to us. The patient had taken a traditional herb medicine, otsu-ji-to, before the onset of pneumonia. A provocation test for each herbal ingredient contained in otsu-ji-to revealed that the pneumonitis had been induced by ou-gon (scullcap). Lymphocytosis with the CD8+ T-cell subset predominance was found in the bronchoalveolar lavage fluid and lymphocytic alveolitis was noted in the transbronchial lung biopsy specimen after the provocation test. Ou-gon, or scullcap, should be included in the list of drugs with definite causal association with pneumonitis.
authors.affiliation: Department of Medicine, Keio University School of Medicine, Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Takeshita
authors.forename: Y
authors.initials: Y
authors.lastname: Saisho
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: N
authors.initials: N
authors.lastname: Kaburagi
authors.forename: T
authors.initials: T
authors.lastname: Funabiki
authors.forename: T
authors.initials: T
authors.lastname: Inamura
authors.forename: Y
authors.initials: Y
authors.lastname: Oyamada
authors.forename: K
authors.initials: K
authors.lastname: Asano
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D001706:Biopsy; D018414:CD8-Positive T-Lymphocytes; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D020835:Medicine, Kampo; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D004365:Drugs, Chinese Herbal