[Features of microcirculatory disorders in acute and recurrent hemorrhagic vasculitis (Schönlein-Henoch disease)].
OBJECTIVE
To study microcirculatory disturbances in acute and chronic hemorrhagic vasculitis (HV).


METHODS
The examination of 44 HV patients included clinical and immunological examinations, conjunctival biomicroscopy, tests for blood viscosity, aggregation of erythrocytes, coagulation parameters. In 8 patients morphological examination of skin microvessels was made (light microscopy and electron microscopy).


RESULTS
Changes in microcirculation of patients with acute HV were characterized by increased IgA and red cell aggregation, tendency to hypercoagulation. Morphologically, there was high permeability of the microvessels wall. In patients with chronic HV laboratory parameters normalized except elevated level of circulating immune complexes and red cell aggregation. Morphological picture of microcirculatory disturbances in patients with chronic HV was characterized by productive vasculitis.


CONCLUSIONS
In HV patients microcirculatory disorders caused by immunologic mechanisms are realized through increased permeability of microvessel wall, high aggregation of erythrocytes in microvessels and hypercoagulation in acute HV. In patients with chronic HV productive vasculitis and high aggregation of erythrocytes are registered.
Nazarova
O A
OA
Bobkov
V A
VA
Ionova
S V
SV
Drozdova
T V
TV
D000208:Acute Disease; D000328:Adult; D001777:Blood Coagulation; D001809:Blood Viscosity; D002199:Capillary Permeability; D004903:Erythrocyte Aggregation; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D012008:Recurrence; D012867:Skin / Q000098:blood supply / Q000473:pathology
Osobennosti mikrotsirkuliatornykh narusheniĭ pri ostrom i retsidiviruiushchem gemorragicheskom vaskulite (bolezni Shenleĭna-Genokha).