Lethal adenovirus infection in a patient who had undergone nonmyeloablative stem cell transplantation.
We present a case of adenovirus (ADV) infection in a patient who had undergone nonmyeloablative stem cell transplantation (NST). A 50-year-old man with chronic myelogenous leukemia in the second chronic phase underwent NST from an HLA 2-loci-mismatched sibling. ADV hemorrhagic cystitis developed and progressed to lethal pneumonia. ADV was isolated from urine, bronchoalveolar lavage fluid, and postmortem specimens of kidney and liver. Because there are few reports of lethal pneumonia associated with ADV in Japan, we present the case and discuss the cause of and therapy for the infection.
Ikegame
K
K
Department of Molecular Medicine, Osaka University Medical School, Suita, Japan.
Takimoto
T
T
Takahashi
R
R
Murakami
M
M
Tamaki
H
H
Fujioka
T
T
Kawakami
M
M
Hirabayashi
N
N
Soma
T
T
Sugiyama
H
H
Ogawa
H
H
D000257:Adenoviridae Infections / Q000209:etiology*; D000260:Adenoviruses, Human / Q000302:isolation & purification; D000961:Antilymphocyte Serum; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D002066:Busulfan; D003556:Cystitis / Q000150:complications / Q000821:virology; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D015466:Leukemia, Myeloid, Chronic-Phase / Q000150:complications / Q000628:therapy; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000209:etiology* / Q000821:virology; D013601:T-Lymphocytes; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D014740:Vidarabine / Q000031:analogs & derivatives*
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D014740:Vidarabine; D002066:Busulfan; C024352:fludarabine; D016559:Tacrolimus; D008775:Methylprednisolone