[Mechanisms of biocidal action of neutrophils in patients with alcoholism and kidney damage of the chronic pyelonephritis type].
OBJECTIVE
To study mechanisms of biocenosis action of neutrophils in alcoholics with chronic pyelonephritis (CP).


METHODS
Functional potential of oxidase neutrophil system was studied in 37 males with chronic alcoholism stage II. 17 of them had CP. They were compared to 18 CP non-alcohol abusers (controls).


RESULTS
CP alcoholics had lower potential of oxidase neutrophil system than controls and healthy subjects.


CONCLUSIONS
Dysfunction of axygen-dependent mechanisms of biocidic action of neutrophils in chronic alcoholics weakens the ability of the organism to eliminate infection and can entail defects in immune response.
Tarasova
N S
NS
Beloborodova
E I
EI
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000150:complications*; D000818:Animals; D002478:Cells, Cultured; D016009:Chi-Square Distribution; D002908:Chronic Disease; D006801:Humans; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D018375:Neutrophil Activation; D009504:Neutrophils / Q000201:enzymology / Q000502:physiology*; D010088:Oxidoreductases / Q000097:blood; D009195:Peroxidase / Q000097:blood; D011704:Pyelonephritis / Q000209:etiology*; D013997:Time Factors
D010088:Oxidoreductases; D009195:Peroxidase
Mekhanizmy biotsidnogo deĭstviia neĭtrofilov u bol'nykh alkogolizmom s porazheniem pochek po tipu khronicheskogo pielonefrita.