Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species.
Phomoxanthones A (1) and B (2), two novel xanthone dimers, were isolated from the endophytic fungus Phomopsis sp. BCC 1323. Structures of 1 and 2 were elucidated by spectroscopic methods. These compounds exhibited significant in vitro antimalarial and antitubercular activities and cytotoxicity.
Isaka
M
M
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Rama 6 Road, Bangkok 10400, Thailand. isaka@biotec.or.th
Jaturapat
A
A
Rukseree
K
K
Danwisetkanjana
K
K
Tanticharoen
M
M
Thebtaranonth
Y
Y
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D002294:Carcinoma, Squamous Cell; D002522:Chlorocebus aethiops; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007938:Leukemia; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013785:Thailand; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014709:Vero Cells / Q000187:drug effects; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones
D000962:Antimalarials; D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D014966:Xanthenes; D044004:Xanthones; C436523:deacetylphomoxanthone A; C436332:phomoxanthone A; C436333:phomoxanthone B