46, XY pure gonadal dysgenesis: a case with Graves' disease and exceptionally tall stature.
A case of 46, XY pure gonadal dysgenesis with very tall stature was investigated. The 24-year-old, phenotypically female patient consulted our clinic because of linear growth persisting into adulthood. The patient was found to have no mutation or deletion of a sex-determining region of the Y chromosome, and also was found to have Graves' disease. Growth was arrested with height remaining at 187 cm after normalization of the thyroid function by treatment with an antithyroid agent, although follow-up to monitor growth was limited to 3 months. In some cases of gonadal dysgenesis, then, Graves' disease may contribute to an abnormally tall stature.
Kawamura
M
M
Second Department of Internal Medicine, Iwate Prefectural Central Hospital, Morioka.
Owada
M
M
Kimura
Y
Y
Fujiwara
T
T
Sasaki
A
A
Tajima
T
T
Fujieda
K
K
Hiramori
K
K
D000328:Adult; D000365:Age Determination by Skeleton; D013956:Antithyroid Agents / Q000627:therapeutic use; D001827:Body Height; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D006111:Graves Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D011441:Propylthiouracil / Q000627:therapeutic use; D016896:Treatment Outcome
D013956:Antithyroid Agents; D011441:Propylthiouracil