Genotoxic evaluation of the effect of Thuya occidentalys tinctures.
Three tinctures samples from extracts of the popular medicinal plant Thuya occidentalis were tested in vitro through two short term tests for measuring the activity of genotoxic chemicals. Using the Salmonella/mammalian-microsome (Mutatest) assay and the SOS-chromotest (induction of beta-galactosidase in Escherichia coli), none of the extract was effective in inducing mutagenesis or beta-galactosidase synthesis (as an indicator of general and early sign of DNA damage), even with metabolization.
Valsa
J O
JO
Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Felzenszwalb
I
I
D004396:Coloring Agents / Q000633:toxicity*; D004926:Escherichia coli / Q000187:drug effects; D009152:Mutagenicity Tests / Q000379:methods*; D010936:Plant Extracts / Q000633:toxicity*; D013014:SOS Response, Genetics; D012486:Salmonella typhimurium / Q000187:drug effects
D004396:Coloring Agents; D010936:Plant Extracts