title: MR diffusion tensor imaging of white matter tract disruption in stroke at 3 T.
abstract: Recent advances in MR diffusion weighted imaging (DWI) enable the identification of anisotropic white matter tracts with diffusion tensor imaging (DTI). We aimed to use a novel DTI technique to safely study patients with recent stroke in a high field (3 T) MR machine with its intrinsically higher spatial resolution and signal-to-noise ratio. Of ten patients studied, six had disruption of white matter tracts as determined by DTI. A further patient had distortion of white matter tracts around an infarct rather than actual disruption of the tracts themselves. The lack of tract destruction may imply a beneficial prognosis, information that is not available with conventional DWI.
authors.affiliation: Department of Radiology, University of Cambridge, Cambridge CB2 2QQ, UK.
authors.forename: J H
authors.initials: JH
authors.lastname: Gillard
authors.forename: N G
authors.initials: NG
authors.lastname: Papadakis
authors.forename: K
authors.initials: K
authors.lastname: Martin
authors.forename: C J
authors.initials: CJ
authors.lastname: Price
authors.forename: E A
authors.initials: EA
authors.lastname: Warburton
authors.forename: N M
authors.initials: NM
authors.lastname: Antoun
authors.forename: C L
authors.initials: CL
authors.lastname: Huang
authors.forename: T A
authors.initials: TA
authors.lastname: Carpenter
authors.forename: J D
authors.initials: JD
authors.lastname: Pickard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D020521:Stroke / Q000175:diagnosis*