title: Intubating conditions after three different doses of rocuronium in the elderly.
abstract: This randomized controlled trial study evaluated the intubating conditions at 1 minute after 0.3, 0.6 and 0.9 mg/kg of rocuronium in 60 Thai elderly patients who enrolled for elective surgery under general anesthesia with fentanyl, thiopental and halothane at King Chulalongkorn Memorial Hospital. Excellent or good conditions were observed in 50 per cent (p<0.05) at rocuronium 0.3 mg/kg, compared with 95 and 85 per cent at 0.6 and 0.9 mg/kg of rocuronium, respectively but the excellent conditions were 5 (p<0.05), 30 and 45 per cent from each dose. Therefore, rocuronium 0.6 or 0.9 mg/kg should be adequate for intubation in elective, elderly patients but was inadequate for emergency case. In addition, rocuronium 0.3 mg/kg is insufficient for intubation at 1 minute in this age group. No serious side effects of the drug nor complications were found in this study.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Bunburaphong
authors.forename: T
authors.initials: T
authors.lastname: Werawatganon
authors.forename: K
authors.initials: K
authors.lastname: Panyarachun
authors.forename: J
authors.initials: J
authors.lastname: Vimala
authors.forename: J
authors.initials: J
authors.lastname: Chainongbua
authors.forename: J
authors.initials: J
authors.lastname: Tungamornsatit
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000732:Androstanols / Q000008:administration & dosage* / Q000009:adverse effects; D001795:Blood Pressure Determination; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004638:Emergency Treatment / Q000379:methods; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D000077123:Rocuronium; D016896:Treatment Outcome
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium