Influence of gender on intraluminal thrombus of abdominal aortic aneurysms.
BACKGROUND
The mechanisms of formation of intraluminal thrombus (ILT) of abdominal aortic aneurysms (AAA) remain unknown. The aim of this study was to investigate the pathogenesis of AAA by analysis of ILT.


METHODS
We retrospectively analyzed the size of ILT in 98 consecutive patients with AAA undergoing abdominal computed tomography (CT) examination. The volume of ILT was estimated by the area ratio of ILT in CT images. Important baseline variables related to small ILT were determined using logistic-regression analysis.


RESULTS
There were two apparent peaks in the distribution of ILT ratio. Thirteen of 98 patients had negligible ILT with ratio < or = 0.1. Female gender was the only patient characteristic independently significantly correlated with small ILT (odds ratio 5.214, P = 0.0096).


CONCLUSIONS
Our findings provide important evidence that AAA is formed by at least two different pathogenic processes. It is likely that this difference in mechanisms may be caused partly by sex hormones.
Yasuhara
H
H
Department of Surgery, Teikyo University Ichihara Hospital, 3426-3 Anesaki, 299-0111, Ichihara City, Chiba, Japan. yasuhart-tky@umin.ac.jp
Ohara
N
N
Nagawa
H
H
D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D012306:Risk; D012737:Sex Factors; D013927:Thrombosis / Q000473:pathology*