title: Surgical closure of patent ductus arteriosus in very-low-birth-weight infants.
abstract: In many very-low-birth-weight (VLBW) infants the ductus arteriosus fails to close spontaneously, and they subsequently develop signs and symptoms of poor tissue perfusion and heart failure. This study evalutes the results of early surgical closure of patent ductus arteriosus (PDA). We retrospectively reviewed the records of all 101 VLBW infants who weighed 1,500 g or less when their PDA was surgically ligated in Turku University Hospital between 1988 and 1998. The mean gestational age at birth was 27.2 weeks and mean birth weight 963+/-239 g. The operation was performed at 12+/-8 days of age; the infants' weight at operation was 969+/-231 g and they were tracheally extubated 11+/-14 days after the operation. The surgery-related mortality was 3% (3/101) and overall mortality 10% (10/101). We conclude that surgical closure of PDA is safe and effective in VLBW infants.
authors.affiliation: Department of Pediatrics, University of Turku, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Niinikoski
authors.forename: M
authors.initials: M
authors.lastname: Alanen
authors.forename: T
authors.initials: T
authors.lastname: Parvinen
authors.forename: R
authors.initials: R
authors.lastname: Aantaa
authors.forename: H
authors.initials: H
authors.lastname: Ekblad
authors.forename: P
authors.initials: P
authors.lastname: Kero
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000401:mortality / Q000601:surgery*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008297:Male; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin