Effects of a short-term suspension of hormone replacement therapy on mammographic density.
OBJECTIVE
To evaluate the effects of hormone replacement therapy (HRT) and of a short-term suspension of HRT on mammographic density.


METHODS
Prospective clinical study.


METHODS
Outpatient menopausal clinic of the Second University of Naples.


METHODS
Ninety-seven healthy postmenopausal women.


METHODS
Thirty-nine menopausal women with intact uterus (group A) were treated with continuous transdermal E(2) plus acetate nomegestrolo sequentially added, 37 women in surgical menopause (group B) were treated with transdermal E(2) continuously administered, and 21 menopausal women did not receive any medication (group C). At the entry and after 12 months, a mammography was performed without suspension of HRT (group A1: 19 women; group B1: 19 women) or after a short-term suspension (group A2: 20 women; group B2: 18 women).


METHODS
Mammographic density evaluated according to a quantitative method.


RESULTS
At the second mammography, seven patients in group A1, four patients in group B1, and one patient in both groups A2 and B2 showed an increase in mammographic density, whereas no mammographic density increase was observed in patients in group C. A statistically significant difference in the mammographic density increase was found between group A1 and group A2; no difference was found between group B1 and B2.


CONCLUSIONS
Suspension of HRT for about 3 weeks may reverse mammographic density increase associated with its use.
Colacurci
N
N
Outpatient Menopausal Clinic, Institute of Gynecology and Obstetrics, School of Medicine, Second University of Naples, Naples, Italy. colacurci@hotmail.com
Fornaro
F
F
De Franciscis
P
P
Mele
D
D
Palermo
M
M
del Vecchio
W
W
D000279:Administration, Cutaneous; D015519:Bone Density; D004338:Drug Combinations; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood; D015914:Estrogen Replacement Therapy; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007044:Hysterectomy; D008327:Mammography; D008535:Megestrol; D008593:Menopause; D008875:Middle Aged; D009649:Norpregnadienes / Q000008:administration & dosage; D010298:Parity; D017698:Postmenopause; D011446:Prospective Studies; D013997:Time Factors
D004338:Drug Combinations; D009649:Norpregnadienes; D004958:Estradiol; C038501:nomegestrol acetate; D005640:Follicle Stimulating Hormone; D008535:Megestrol