Synthesis of d-labeled N-alkylmaleimides and application to quantitative peptide analysis by isotope differential mass spectrometry.
d-Labeled N-alkylmaleimides have been prepared for specific modification of the terminal SH groups of cysteine residues in proteins or peptides. These reagents are useful tools for quantitative analysis of peptides by stable isotope differential mass spectrometry.
Niwayama
S
S
Department of Chemistry, Oklahoma State University, Stillwater, OK 74078-3071, USA. niwayama@biochem.okstate.edu
Kurono
S
S
Matsumoto
H
H
D000595:Amino Acid Sequence; D002247:Carbon Isotopes; D008301:Maleimides / Q000138:chemical synthesis*; D008969:Molecular Sequence Data; D010455:Peptides / Q000032:analysis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
D002247:Carbon Isotopes; D008301:Maleimides; D010455:Peptides