title: Enhancement of endogenous corticosterone levels by a macrolide antibiotic, roxithromycin in mice.
abstract: The influence of roxithromycin (RXM), a macrolide antibiotic, on endogenous corticosterone (CS) levels was examined in BALB/c mice. Mice were sensitized intraperitoneally with two doses of Keyhole Limpet Hemocyanin at 1 week intervals. Mice were given orally 2.5 mg/kg RXM once a day for 14 days starting 7 days after the first sensitization. RXM administration caused markedly increase in endogenous plasma CS levels which was peaked at 60 min after the administration. However, josamycin did not influence on endogenous CS levels in plasma. Injection of dexamethasone inhibits the plasma CS hyperproduction induced by RXM treatment.
authors.affiliation: Department of Otolaryngology, School of Medicine, Showa University, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Asano
authors.forename: T
authors.initials: T
authors.lastname: Shimane
authors.forename: T
authors.initials: T
authors.lastname: Hisamitsu
authors.forename: H
authors.initials: H
authors.lastname: Suzaki
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D003907:Dexamethasone / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006433:Hemocyanins / Q000276:immunology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007114:Immunization; D007165:Immunosuppression Therapy; D015570:Josamycin / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D015575:Roxithromycin / Q000494:pharmacology*; D013047:Specific Pathogen-Free Organisms
chemical_list: D000485:Allergens; D000900:Anti-Bacterial Agents; D015575:Roxithromycin; D003907:Dexamethasone; D006433:Hemocyanins; D015570:Josamycin; D003345:Corticosterone