Age-related effects of genetic variation on lipid levels: The Columbia University BioMarkers Study.
OBJECTIVE
To examine the genotype:phenotype association in children compared with their parents.


METHODS
Variations at 4 key gene loci, namely lipoprotein lipase (LPL S447X), hepatic lipase (HL -480C>T), cholesteryl ester transfer protein (CETP TaqIB), and apolipoprotein CIII (APOC3 -455T>C and -482C>T), were examined in children (n = 495) and their parents (n = 353) in the Columbia University BioMarkers Study, 1994 to 1998.


RESULTS
The frequencies of the rare alleles of the HL -480C>T and APOC3 -455T>C and -482C>T (but not LPL S447X or CETP TaqIB) were significantly lower in non-Hispanic white participants compared with Hispanics. Overall, genotype effects seen in the adults were weaker in the children, although similar trends were seen. In an examination of the effect of body fat on the genotypic effects in the children, there was significant HL -480C>T:sum of skinfold interaction.


CONCLUSIONS
All genotypes were associated with clear relationships to plasma lipid levels in adults, but the effects were weaker in their children, unless stressed by body fat. atherosclerosis, cardiovascular disease, child, lipids, genetics.
Talmud
P J
PJ
Center for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, London, United Kingdom. p.talmud@ucl.ac.uk
Berglund
L
L
Hawe
E M
EM
Waterworth
D M
DM
Isasi
C R
CR
Deckelbaum
R E
RE
Starc
T
T
Ginsberg
H N
HN
Humphries
S E
SE
Shea
S
S
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D002784:Cholesterol / Q000097:blood; D053480:Cholesterol Ester Transfer Proteins; D003327:Coronary Disease / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006023:Glycoproteins; D006579:Heterozygote; D006630:Hispanic or Latino; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000235:genetics*; D008099:Liver / Q000201:enzymology; D008297:Male; D008487:Medical History Taking; D010641:Phenotype; D044465:White People / Q000235:genetics*
D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; D015415:Biomarkers; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008055:Lipids; D002784:Cholesterol; D008049:Lipase; D008071:Lipoprotein Lipase