Cyclodextrin complexes of salts of acidic drugs. Thermodynamic properties, structural features, and pharmaceutical applications.
The objective of this mini-review is to summarize the findings concerning the physicochemical properties and the pharmaceutical applications of acidic drugs whose performances have been modified by simultaneous complexation with cyclodextrins and salt formation. Particular attention is paid to the approaches undertaken for increasing the solubility of the drugs by proper choice of the type of counterion analogously to what has been reported for complexes of basic drugs in the presence of hydroxy acids.
Redenti
E
E
R&D Department, Chiesi Farmaceutici S.p.A., Via Palermo 26/A, 43100 Parma, Italy. e.redenti@chiesigroup.com
Szente
L
L
Szejtli
J
J
D000143:Acids / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D001647:Bile Acids and Salts / Q000737:chemistry* / Q000494:pharmacology; D003505:Cyclodextrins / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D012492:Salts / Q000737:chemistry; D013816:Thermodynamics; D047392:beta-Cyclodextrins
D000143:Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001647:Bile Acids and Salts; D003505:Cyclodextrins; D007004:Hypoglycemic Agents; D012492:Salts; D047392:beta-Cyclodextrins; C031215:betadex