title: [Altered left ventricular diastolic function in patients with lymphogranulomatosis].
abstract: Impaired elastic characteristics of the left heart ventricle and restructuring of its diastolic bloodflow were revealed in 28 patients with Hodgkin's disease by complex Doppler echocardiographic study of intracardiac hemodynamics. The most pronounced disorders of the diastolic function were detected in patients with pericardial involvement. More pronounced tumor intoxication in patients with mixed-cell variant of the tumor resulted in remodeling of the left ventricle, left atrial dysfunction, and restructuring of the diastolic bloodflow, which indicated combined impairment of the left ventricular diastolic relaxation and left atrial contractility. Chemotherapy augmented disorders in diastolic bloodflow, the increase in the number of polychemotherapy courses being associated with a trend to deterioration of left-ventricular relaxation. Hence, tumor intoxication and drug cardiotoxicity determine the formation of central hemodynamic disorders, one of whose principal components is diastolic dysfunction of the left heart ventricle.
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Shevchenko
authors.forename: L L
authors.initials: LL
authors.lastname: Bobrov
authors.forename: A A
authors.initials: AA
authors.lastname: Novik
authors.forename: A G
authors.initials: AG
authors.lastname: Obrazan
authors.forename: O B
authors.initials: OB
authors.lastname: Krysiuk
mesh_terms: D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology*; D018608:Ultrasonography, Doppler / Q000379:methods; D018754:Ventricular Dysfunction / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*
vernacular_title: Izmeneniia diastolicheskoĭ funktsii levogo zheludochka serdtsa u bol'nykh limfogranulematozom.