Medicinal foodstuffs. XXV. Hepatoprotective principle and structures of ionone glucoside, phenethyl glycoside, and flavonol oligoglycosides from young seedpods of garden peas, Pisum sativum L.
A new ionone glucoside, pisumionoside, a phenethyl glycoside, sayaendoside, and two acylated flavonol oligoglycosides, pisumflavonosides I and II, were isolated from the young seedpods of garden peas, Pisum sativum L., together with quercetin and kaempferol 3-O-(6-O-trans-p-coumaroyl)-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranosides and quercetin and kaempferol 3-sophorotriosides. The structures of pisumionoside, sayaendoside, and pisumflavonosides I and II were determined on the basis of chemical and physicochemical evidence, respectively. Quercetin 3-sophorotrioside, a principle component, was found to show protective effects on liver injury induced by D-galactosamine and lipopolysaccharide and by carbon tetrachloride in mice.
Murakami
T
T
Kyoto Pharmaceutical University, Japan.
Kohno
K
K
Ninomiya
K
K
Matsuda
H
H
Yoshikawa
M
M
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury; D044950:Flavanones; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005688:Galactosamine / Q000633:toxicity; D005960:Glucosides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects* / Q000473:pathology; D007274:Injections, Intraperitoneal; D008070:Lipopolysaccharides / Q000633:toxicity; D008107:Liver Diseases / Q000517:prevention & control; D008297:Male; D051379:Mice; D018532:Pisum sativum / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
D044950:Flavanones; D005419:Flavonoids; D005960:Glucosides; D006027:Glycosides; D008070:Lipopolysaccharides; D010936:Plant Extracts; D005688:Galactosamine; D002251:Carbon Tetrachloride; C028610:flavanone