New insight in cdk9 function: from Tat to MyoD.
Cdk9 is a serine-threonine cdc2-related kinase and its activity is not cell cycle-regulated. Cdk9 function depends on its kinase activity and also on its regulatory units: the T-family cyclins and cyclin K. Recently, several studies confirmed the role of cdk9 in different cellular processes such as signal transduction, basal transcription, HIV-Tat- and MyoD-mediated transcription and differentiation. All the referred data strongly support the concept of a multifunctional protein kinase with specific cytoplasmic and nuclear functions.
Simone
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Dept. of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Giordano
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D000818:Animals; D002454:Cell Differentiation; D042863:Cyclin-Dependent Kinase 9; D018844:Cyclin-Dependent Kinases / Q000502:physiology*; D015696:Gene Products, tat / Q000502:physiology; D006801:Humans; D017570:MyoD Protein / Q000502:physiology; D014158:Transcription, Genetic
D015696:Gene Products, tat; D017570:MyoD Protein; C467969:CDK9 protein, human; D042863:Cyclin-Dependent Kinase 9; D018844:Cyclin-Dependent Kinases