Serum anti-p53 autoantibodies in patients with type 1 diabetes.
The presence of antibodies reacting with the p53 tumor suppressor protein has been described in patients with some autoimmune disorders. In this study we looked for serum anti-p53 antibodies in 64 patients with autoimmune type 1 diabetes mellitus within 4 mo of diagnosis. The presence of anti-p53 antibodies was observed in 6/64 (9.4%) subjects with type 1 diabetes, and in 1/44 (2.3%) subjects with other organ-specific autoimmune diseases (18 primary biliary cirrhosis, 10 autoimmune hepatitis, 16 thyroid diseases), but in none of 45 control subjects. No relationship was found between antibodies directed against islet- and non-islet-specific antigens and anti-p53 antibodies. These findings support a possible role for p53 in some autoimmune disorders.
Di Cesare
E
E
Department of Internal Medicine, University of Messina, Italy. domenico.cucinotta@unime.it
Previti
M
M
Lombardo
F
F
Di Benedetto
A
A
Mazzù
N
N
Romano
G
G
De Luca
F
F
Lasco
A
A
Cucinotta
D
D
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007223:Infant; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
D001323:Autoantibodies; D007070:Immunoglobulin A; D016159:Tumor Suppressor Protein p53