Estimation of antithyroid drug dose in Graves' disease: value of quantification of thyroid blood flow with color duplex sonography.
The purpose of this study was to evaluate if there is an association between the antithyroid drug dose that is needed to establish euthyroidism and thyroid blood flow measurements. A total of 23 Graves' disease patients with euthyroidism taking antithyroid drug therapy were enlisted to undergo spectral duplex sonography of the thyroid arteries and color-flow mapping of the thyroid gland. Color pixel density (CPD) was calculated with computer assistance from the color-flow maps. There was a strong correlation between the CPD and methimazole dose (rp = 0.79). Methimazole maintenance dosage could be predicted from CPD values with a coefficient of determination of 0.62. In conclusion, CPD measurements could be a useful tool for the clinical endocrinologist to estimate the antithyroid drug dose that is needed to maintain euthyroidism.
Saleh
A
A
Institute of Diagnostic Radiology, Heinrich Heine University, Düsseldorf, Germany. saleh@uni-duesseldorf.de
Fürst
G
G
Feldkamp
J
J
Godehardt
E
E
Grust
A
A
Mödder
U
U
D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008713:Methimazole / Q000008:administration & dosage* / Q000627:therapeutic use; D012039:Regional Blood Flow; D013961:Thyroid Gland / Q000098:blood supply* / Q000000981:diagnostic imaging*; D018615:Ultrasonography, Doppler, Color
D013956:Antithyroid Agents; D008713:Methimazole