Bile acid reflux and possible inhibition of Helicobacter pylori infection in subjects without gastric surgery.
Bile acids are generally known to inhibit growth of Helicobacter pylori in vitro, but whether they do so in humans with no gastric surgery has been uncertain. The present study addresses this issue. Among healthy control subjects with preserved acid secretion, H. pylori-positive subjects were older and had lower gastric bile acid concentrations than H. pylori-negative subjects (P < 0.05). Among gastric ulcer patients with preserved acid secretion, H. pylori-positive patients had a higher basal acid output than H. pylori-negative patients (P < 0.05). Among H. pylori-positive subjects with preserved acid secretion, duodenal ulcer patients had a higher basal and maximum acid output than healthy control subjects (P < 0.01). In conclusion, gastric bile acids may suppress initial stages of H. pylori infection in subjects without gastric surgery. However gastric bile acids may have little effect on peptic ulcer disease, once H. pylori infection is established.
Kawai
Y
Y
First Department of Internal Medicine, Institute of Health Sciences, Hiroshima University School of medicine, Japan.
Tazuma
S
S
Inoue
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000641:Ammonia / Q000032:analysis; D001647:Bile Acids and Salts / Q000737:chemistry; D001655:Bile Reflux / Q000150:complications / Q000382:microbiology*; D002648:Child; D004381:Duodenal Ulcer / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D005744:Gastric Acid / Q000737:chemistry / Q000378:metabolism; D005745:Gastric Acidity Determination; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D016480:Helicobacter pylori / Q000254:growth & development; D006801:Humans; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000382:microbiology / Q000503:physiopathology
D001647:Bile Acids and Salts; D000641:Ammonia