title: Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis.
abstract: Numerical simulations of pulsatile blood flow in straight tube stenosis models were performed to investigate the poststenotic flow phenomena. In this study, three axisymmetrical and three asymmetrical stenosis models with area reduction of 25%, 50% and 75% were constructed. A measured human common carotid artery blood flow waveform was used as the upstream flow condition which has a mean Reynold's number of 300. All calculations were performed with high spatial and temporal resolutions. Flow features such as velocity profiles, flow separation zone (FSZ), and wall shear stress (WSS) distributions in the poststenotic region for all models are presented. The results have demonstrated that the formation and development of FSZs in the poststenotic region are very complex, especially in the flow deceleration phase. In axisymmetric stenoses the poststenotic flow is more sensitive to changes in the degree of stenosis than in asymmetric models. For severe stenoses, the stenosis influence length is shorter in asymmetrical models than in axisymmetrical cases. WSS oscillations (between positive and negative values) have been observed at various downstream locations in some models. The amplitude of the oscillation depends strongly on the axial location and the degree of stenosis.
authors.affiliation: Department of Chemical Engineering and Chemical Technology, Imperial College, Prince Consort Road, London SW7 2BY, UK. q.long@ic.ac.uk
authors.forename: Q
authors.initials: Q
authors.lastname: Long
authors.forename: X Y
authors.initials: XY
authors.lastname: Xu
authors.forename: K V
authors.initials: KV
authors.lastname: Ramnarine
authors.forename: P
authors.initials: P
authors.lastname: Hoskins
mesh_terms: D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology*; D013314:Stress, Mechanical