title: Re-evaluating centrosome function.
abstract: Over the past 100 years, the centrosome has risen in status from an enigmatic organelle, located at the focus of microtubules, to a key player in cell-cycle progression and cellular control. A growing body of evidence indicates that centrosomes might not be essential for spindle assembly, whereas recent data indicate that they might be important for initiating S phase and completing cytokinesis. Molecules that regulate centrosome duplication have been identified, and the expanding list of intriguing centrosome-anchored activities, the functions of which have yet to be determined, promises continued discovery.
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA. stephen.doxsey@umassmed.edu
authors.forename: S
authors.initials: S
authors.lastname: Doxsey
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018385:Centrosome / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D009369:Neoplasms / Q000209:etiology; D008941:Spindle Apparatus / Q000378:metabolism