Primary adenosquamous carcinoma of the liver which produces granulocyte-colony-stimulating factor and parathyroid hormone related protein: association with leukocytosis and hypercalcemia.
A 55-year-old man was admitted to our hospital with fever and vomiting. Abdominal computed tomography (CT) revealed multiple low density masses in the liver. A diagnosis of primary adenosquamous carcinoma of the liver was confirmed by histological examination of a necropsy specimen. The present case showed leukocytosis and hypercalcemia with high levels of serum granulocyte-colony-stimulating factor (G-CSF) and parathyroid hormone related protein (PTHrP). Recent studies have shown that G-CSF and PTHrP are responsible for the paraneoplastic syndromes with leukocytosis and hypercalcemia. The tumor cells demonstrated positive cytoplasmic immunohistochemistry staining with anti-G-CSF and anti-PTHrP antibodies. This result suggested that the tumor produced G-CSF and PTHrP.
Hayashi
T
T
Department of Internal Medicine, Tokyo Saiseikai Central Hospital.
Mizuki
A
A
Yamaguchi
T
T
Hasegawa
T
T
Kunihiro
T
T
Tsukada
N
N
Matsuoka
K
K
Orikasa
H
H
Yamazaki
K
K
D018196:Carcinoma, Adenosquamous / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007964:Leukocytosis / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D010257:Paraneoplastic Syndromes / Q000378:metabolism; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D016179:Granulocyte Colony-Stimulating Factor