Synthesis of N-(3-arylpropyl)amino acid derivatives by Sonogashira types of reaction in aqueous media.
[reaction: see text]. N-propargylamino acids and peptides including them can be efficiently derivatized in aqueous media with a wide variety of (hetero)aryl halides by cross-coupling reactions catalyzed by palladium on carbon (10% Pd/C).
López-Deber
M P
MP
Departamento de Química Orgánica e Unidade Asociada ó C.S.I.C, Facultade de Química, Universidade de Santiago, 15782 Santiago de Compostela, Spain.
Castedo
L
L
Granja
J R
JR