title: [Role of life events on onset of major depression].
abstract: Many kinds of stressful life events have been regarded as important factors in the causation and management of depression, based on empirical and descriptive studies. The instrument for assessment of life events has been established. There is consistent evidence for dose-response relationship between stressful events and depression. The effect of life events close to onset is more important, but sometimes the expected response appears after a delay. The effect of life events varies by early adverse experience, cognition and genetics. The association between life events exposure and risk of major depression progressively declines, it is consistent with the kindling hypothesis.
authors.affiliation: Department of Neuropsychiatry, Oita Medical University.
authors.forename: Y
authors.initials: Y
authors.lastname: Horinouchi
authors.forename: H
authors.initials: H
authors.lastname: Nagayama
mesh_terms: D003863:Depression / Q000209:etiology* / Q000523:psychology; D006801:Humans; D008016:Life Change Events; D012008:Recurrence; D012306:Risk; D013997:Time Factors