title: Leishmaniasis recidivans recurrence after 43 years: a clinical and immunologic report after successful treatment.
abstract: We describe a patient with very late recurring leishmaniasis recidivans from whom lesional biopsy samples were obtained during and after topical steroid treatment that demonstrated the ability of the host to contain the parasite in the absence of therapy. Combination therapy with intralesional sodium stibogluconate and oral itraconazole was successful and immunologic data suggest that both CD4(+) and CD8(+) T cell subsets had roles in this disease process.
authors.affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. mmarovich@hivresearch.org
authors.forename: M A
authors.initials: MA
authors.lastname: Marovich
authors.forename: R
authors.initials: R
authors.lastname: Lira
authors.forename: M
authors.initials: M
authors.lastname: Shepard
authors.forename: G H
authors.initials: GH
authors.lastname: Fuchs
authors.forename: R
authors.initials: R
authors.lastname: Kruetzer
authors.forename: T B
authors.initials: TB
authors.lastname: Nutman
authors.forename: F A
authors.initials: FA
authors.lastname: Neva
mesh_terms: D000818:Animals; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007891:Leishmania / Q000276:immunology; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013256:Steroids / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000981:Antiprotozoal Agents; D013256:Steroids; D017964:Itraconazole; D000967:Antimony Sodium Gluconate