[Treatment of endometriosis with dienogest: preliminary report].
OBJECTIVE
Influence of two hormonal therapies (GnRH agonist--leuprolein acetate and a new progestin--dienogest) on symptoms of endometriosis in patients with different clinical grade of disease.


METHODS
34 women with endometriosis confirmed by laparoscopy and histology were included into the study. Patients were randomized and divided into two therapeutic groups. One group was treated with dienogest and the second with leuprolein acetate during 6 month of study. The intensification of pain was assessed with Visual Analog Scale (VAS) and pelvic symptoms scale before, during (3 month) and after therapy. Dyspareunia was assessed with pelvic symptoms scale before, during (3 month) and after therapy. Frequency of adverse effects was assessed in 1, 3 and 6 month of therapy. Emotional state, bone density and basic serum parameters were assessed before and after therapy.


CONCLUSIONS
Dienogest as well as leuprolein acetate decreased pelvic pain and dyspareunia. There were no differences between these influences. Dienogest did not reveal androgenic activity (did not reveal activity nor intense seborrheic lesions, nor hirsutism, nor voice tone). Dienogest did not reveal hot flashes. Bleeding (caused by dienogest therapy) did not influence hematologic indices nor affected the patients' decision on preterm end of treatment.
Kamiński
K
K
Katedry i Kliniki Patologii Ciazy i Rozrodczości Sl. A. M. w Katowicach.
Fiegler
P
P
Marr
J
J
Moore
C
C
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome
D018931:Antineoplastic Agents, Hormonal; C023635:dienogest; D009277:Nandrolone
Terapia z zastosowaniem dienogestu w leczeniu endometriozy--doniesienie wstepne.