title: Expression of natural peptide antibiotics in human articular cartilage and synovial membrane.
abstract: In view of frequent present use of invasive procedures on limb joints, it is astonishing that articular joint inflammation is a rare event. We questioned whether antimicrobial peptides play a role in protecting human articular cartilage and synovial membrane against inflammatory agents. Our results implicate defensins in the protection of human articular joints against pathogens.
authors.affiliation: Department of Anatomy, Christian Albrecht University of Kiel, Olshausenstr. 40, 24098 Kiel, Germany. fpaulsen@anat.uni-kiel.de
authors.forename: F
authors.initials: F
authors.lastname: Paulsen
authors.forename: T
authors.initials: T
authors.lastname: Pufe
authors.forename: W
authors.initials: W
authors.lastname: Petersen
authors.forename: B
authors.initials: B
authors.lastname: Tillmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000890:Anti-Infective Agents / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D010003:Osteoarthritis / Q000382:microbiology / Q000473:pathology; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology; D023083:beta-Defensins / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; C406407:DEFB1 protein, human; D023083:beta-Defensins