Regiospecific synthesis of 4-(2-oxoalkyl)pyridines.
[reaction: see text]. A new and operationally simple method has been developed for the regiospecific syntheses of 4-(2-oxoalkyl)pyridines from ketones and pyridine in good yields, using triflic anhydride to activate the pyridine ring.
Katritzky
A R
AR
Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, 32611-7200, USA. katritzky@chem.ufl.edu
Zhang
S
S
Kurz
T
T
Wang
M
M
Steel
P J
PJ