Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides.
[reaction: see text]. Functionalized arylmagnesium halides, prepared via an iodine-magnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN.2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities.
Dohle
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Ludwig-Maximilians-Universität München, Institut für Organische Chemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.
Lindsay
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DM
Knochel
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