title: [Two cases of exercise-induced acute renal failure with idiopathic renal hypouricemia].
abstract: Acute renal failure without oliguria developed in a 25-year-old male and a 19-year-old male after exercise. Marked hypouricemia became apparent during improvement of their renal function. Increased excretion of uric acid into the urine, increased fractional excretion of uric acid(clearance ratio of uric acid against creatinine), and normal concentration of plasma xanthine and hypoxanthine were observed in both cases. Probenecid and pyrazinamide loading test suggesting decreased reabsorption of uric acid in the proximal convoluted tubules revealed that presecretory reabsorption defect of uric acid resulted in the hypouricemia in both cases. These two cases were diagnosed as having idiopathic renal hypouricemia.
authors.affiliation: First Department of Internal Medicine, Nara Medical University, Nara, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
authors.forename: H
authors.initials: H
authors.lastname: Uyama
authors.forename: H
authors.initials: H
authors.lastname: Shiiki
authors.forename: S
authors.initials: S
authors.lastname: Yamano
authors.forename: M
authors.initials: M
authors.lastname: Kanauchi
authors.forename: M
authors.initials: M
authors.lastname: Yabuta
authors.forename: K
authors.initials: K
authors.lastname: Dohi
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D015499:Renal Tubular Transport, Inborn Errors / Q000150:complications*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid