title: Henoch-Schönlein purpura after 20 years of renal replacement therapy.
abstract: While the clinical impact of the impaired immune response, commonly described in chronic dialysis patients, is still a matter of discussion, it is usually considered that immunological diseases tend to become progressively less active after the start of regular renal replacement therapy (RRT). We reported a case of Henoch-Schonlein Purpura in a 51-year-old male, on RRT for 20 years, 8 on dialysis and 12 with renal graft, because of ESRD of unknown origin (chronic glomerulonephritis?). The acute onset of the syndrome, presenting purpuric rash, abdominal discomfort and asymmetric joint pain with edema and local signs of acute inflammation, was followed by several relapses over a 2 years period. This biopsy proven diagnosis offered an explanation for his chronic renal failure; furthermore, we conclude that, possibly because of the usually good correction of uremic immunodepression by efficient dialysis (this patient's Kt/V ranged from 1.1 to 1.3 according to Lowrie's formula), the possibility of immune diseases should be carefully considered even in long long-term RRT patients.
authors.affiliation: Chair of Nephrology, Department of Internal Medicine, University of Turin, Italy. gbpiccoli@hotmail.com
authors.forename: G B
authors.initials: GB
authors.lastname: Piccoli
authors.forename: C
authors.initials: C
authors.lastname: Iacuzzo
authors.forename: M
authors.initials: M
authors.lastname: Vischi
authors.forename: F
authors.initials: F
authors.lastname: Bechis
authors.forename: L
authors.initials: L
authors.lastname: Biancone
authors.forename: P
authors.initials: P
authors.lastname: Anania
authors.forename: E
authors.initials: E
authors.lastname: Mezza
authors.forename: M
authors.initials: M
authors.lastname: Quaglia
authors.forename: A
authors.initials: A
authors.lastname: Jeantet
authors.forename: G P
authors.initials: GP
authors.lastname: Segoloni
mesh_terms: D006801:Humans; D011695:IgA Vasculitis / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D017582:Renal Replacement Therapy / Q000009:adverse effects*; D013997:Time Factors