title: Characterizing neurodynamic changes before seizures.
abstract: The study of dynamic changes in neural activity preceding epileptic seizure allows the characterization of a preictal state several minutes before seizure onset. This opens up new perspectives for studying the mechanisms of epileptogenesis as well as for possible therapeutic interventions, which represent a major breakthrough. In this review the authors present and discuss the results from their group in this domain using nonlinear analysis of brain signals, as well as the limitations of this topic and current questions.
authors.affiliation: LENA (laboratoire de Neurosciences Cognitives et Imagerie Cérébrale), CNRS UPR 640, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Le Van Quyen
authors.forename: J
authors.initials: J
authors.lastname: Martinerie
authors.forename: V
authors.initials: V
authors.lastname: Navarro
authors.forename: M
authors.initials: M
authors.lastname: Baulac And
authors.forename: F J
authors.initials: FJ
authors.lastname: Varela
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology; D003344:Cortical Synchronization; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000502:physiology; D017711:Nonlinear Dynamics; D011999:Recruitment, Neurophysiological / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*