title: Primary multiple miliary osteoma cutis and exogenous ochronosis.
abstract: Multiple miliary osteoma cutis (MMOC), a rare disorder characterized by the appearance of numerous bony nodules on the face, was initially classified as a consequence of severe, long-standing acne vulgaris. However, several cases have now been described in patients with no preceding history of acne or other inflammatory conditions. We report such a case of primary MMOC in a 75-year-old African American woman and highlight the differences between these conditions. We also note the incidental histologic finding of exogenous ochronosis, which, in our case, indicates the patient's use of hydroquinone-containing bleaching creams in an attempt to treat the disorder.
authors.affiliation: Medical College of Georgia, Augusta, USA.
authors.forename: P H
authors.initials: PH
authors.lastname: Bowman
authors.forename: J L
authors.initials: JL
authors.lastname: Lesher
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D005153:Facial Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D006873:Hydroquinones / Q000009:adverse effects* / Q000627:therapeutic use; D007150:Immunohistochemistry; D009794:Ochronosis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology*; D010016:Osteoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy
chemical_list: D006873:Hydroquinones; C031927:hydroquinone