title: Management of pregnancy in antiphospholipid syndrome.
abstract: Pregnant women with APS are at high risk of maternal and fetal pregnancy complications. Multidisciplinary teams expert in this condition should coordinate management. Even with current management strategies, the risk of maternal thrombosis, fetal loss, or other adverse obstetric outcomes remains. Close monitoring of the various aspects of this condition may reduce maternal morbidity and improve fetal outcome. The pathogenesis of the adverse pregnancy outcome in APS has not yet been fully elucidated, although active research in this field continues. Until this is ascertained, we must accept that many aspects of management are purely empiric, and it is our duty to counsel patients thoroughly so that they understand the risks and benefits of the treatment options they are offered.
authors.affiliation: Department of Obstetrics and Gynecology, Guy's, St. Thomas', and Whipps Cross Hospitals, London, St. Helier's Hospital, Surrey, United Kingdom. hassan.shehata@ntlworld.com
authors.forename: H A
authors.initials: HA
authors.lastname: Shehata
authors.forename: C
authors.initials: C
authors.lastname: Nelson-Piercy
authors.forename: M A
authors.initials: MA
authors.lastname: Khamashta
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005313:Fetal Death; D006801:Humans; D011225:Pre-Eclampsia / Q000209:etiology / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications / Q000209:etiology
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants