title: Optimising antidepressant use in clinical practice: towards criteria for antidepressant selection.
abstract: BACKGROUND
  Current treatment for depression in primary care and other out-patient settings demonstrates a pattern that is incongruous with the magnitude of the burden of depression suggested by its associated disability.
  
  
  OBJECTIVE
  To review important considerations in current depression treatment with a focus on antidepressant use.
  
  
  METHODS
  Factors influencing the undertreatment of depression in real-world settings are examined.
  
  
  RESULTS
  Patient and clinician behaviour as well as the incentives created by the health care system affect the likelihood of realising effective antidepressant therapy in practice.
  
  
  CONCLUSIONS
  Given the complexities of clinical practice, selection criteria for an antidepressant should include safety, efficacy and tolerability, as well as the ability of the antidepressant to deliver real-world efficacy while balancing health care costs in the long term.
authors.affiliation: Department of Psychiatry, University of Brussels (Erasme Hospital), Route de Lennick 808, 1070 Brussels, Belgium. jmendlew@ulb.ac.be
authors.forename: J
authors.initials: J
authors.lastname: Mendlewicz
mesh_terms: D000928:Antidepressive Agents / Q000191:economics / Q000627:therapeutic use*; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy* / Q000191:economics; D017048:Health Care Costs; D006801:Humans; D010349:Patient Compliance; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents