A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus (JCV) in a tissue culture model: implications for prophylactic and therapeutic treatment of progressive multifocal leukencephalopathy.
The human polyomavirus, JCV, is the etiologic agent of a fatal central nervous system (CNS) demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs predominantly in immunosuppressed patients and remains an intractable complication in AIDS. To date, there are no effective therapies to treat PML. We previously demonstrated that the neuroleptic drug, chlorpromazine, inhibits the endocytic pathway used by JCV to infect glial cells. In this paper, we demonstrate that nontoxic doses of chlorpromazine are effective at inhibiting JCV multiplication and spread in a tissue culture model. The clinical efficacy of this drug or related compounds in treating PML has not been evaluated.
Atwood
W J
WJ
Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island 02912, USA. Walter_Atwood@Brown.edu
D000914:Antibodies, Viral / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002460:Cell Line; D002746:Chlorpromazine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D007577:JC Virus / Q000254:growth & development / Q000276:immunology*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy* / Q000517:prevention & control / Q000821:virology; D009457:Neuroglia / Q000166:cytology / Q000821:virology*; D009500:Neutralization Tests
D000914:Antibodies, Viral; D014150:Antipsychotic Agents; D002746:Chlorpromazine