[A case of pseudomyxoma peritonei treated successfully with intraperitoneal administration of CBDCA and etoposide, followed by local delivery of dextran with CDDP during surgery].
A 77-year-old woman was diagnosed as having pseudomyxoma peritonei originating in the ovary or appendix. Low-molecular dextran and CDDP 70 mg was administered directly into the peritoneal cavity, followed by initial exploratory laparotomy with total abdominal hysterectomy, bilateral salpingo-oophorectomy, appendectomy, and omentectomy. During surgery, an implantable port system was positioned to facilitate repeated intraperitoneal administration. Dextran was used with mucolytic therapy and augmentable efficacy of drug administered simultaneously. Within three weeks after surgery, four courses of intraperitoneal CBDCA 300 mg and etoposide 100 mg were administered at four-week intervals. The patient has remained in good general condition with no sign of recurrence for one year. This chemotherapy regimen has minimum side effects and seems effective in maintaining quality of life.
Shiraishi
S
S
Dept. of Obstetrics and Gynecology, Ootawara Red Cross Hospital.
Sakurai
N
N
Tanaka
Y
Y
Iwahashi
K
K
Kitaoka
Y
Y
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D018291:Cystadenoma, Mucinous / Q000601:surgery; D003911:Dextrans / Q000008:administration & dosage*; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007274:Injections, Intraperitoneal; D007430:Intraoperative Care; D007813:Laparotomy; D010051:Ovarian Neoplasms / Q000601:surgery; D010052:Ovariectomy; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D011553:Pseudomyxoma Peritonei / Q000188:drug therapy*
D003911:Dextrans; D005047:Etoposide; D016190:Carboplatin; D002945:Cisplatin