Synthetic transformations of eleutherobin reveal new features of its microtubule-stabilizing pharmacophore.
Britton
R
R
Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z1.
de Silva
E D
ED
Bigg
C M
CM
McHardy
L M
LM
Roberge
M
M
Andersen
R J
RJ
D000470:Alkaloids / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D004224:Diterpenes; D008870:Microtubules / Q000187:drug effects; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism
D000470:Alkaloids; D000970:Antineoplastic Agents; D004224:Diterpenes; D014404:Tubulin; C109551:eleutherobin