Preparation and blood compatibility of polysiloxane/liquid-crystal composite membranes.
Polysiloxane/liquid crystal composite membrane was first suggested to be used as biomaterials. In this work, the polydimethyl-methylhydrosiloxane and polydimethyl-methylethylenesilosiane, as a substrate, were blended with cholesteryl oleyl carbonate (COC) in tetrahydrofuran, and then crosslinked into membranes on glass plates by means of the platinum catalyst at 110 degrees C for 20 min. The effects of the liquid-crystal content in composite membranes on the formation of liquid-crystal phase were verified by the observation of optical polarization microscopy. The relationship between the morphology of the composite membranes and blood compatibility was identified by the dynamic blood-clotting tests, haemolysis ratio measurement, platelet adhesion and SEM observation. The results show that the blood-compatibility of composite membranes with the concentration of liquid crystal 20, 30% (wt) is more excellent than that of other composite membranes.
Li
L
L
Institute of Biomedical Engineering, Jinan University, Guangzhou, People's Republic of China.
Tu
M
M
Mou
S
S
Zhou
C
C
D001672:Biocompatible Materials; D001790:Blood Physiological Phenomena; D001792:Blood Platelets / Q000648:ultrastructure; D002788:Cholesterol Esters; D003432:Cross-Linking Reagents; D005663:Furans; D006461:Hemolysis; D006648:Histocompatibility / Q000502:physiology*; D006801:Humans; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D008859:Microscopy, Polarization; D010973:Platelet Adhesiveness / Q000502:physiology*; D012833:Siloxanes; D012997:Solvents
D001672:Biocompatible Materials; D002788:Cholesterol Esters; D003432:Cross-Linking Reagents; D005663:Furans; D008567:Membranes, Artificial; D012833:Siloxanes; D012997:Solvents; C446741:cholesteryl oleoyl carbonate; C018674:tetrahydrofuran