title: Acute renal failure in a patient with paroxysmal nocturnal hemoglobinuria.
abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder characterized by low-grade, chronic hemolytic anemia accompanied by either thrombocytopenia or leucopenia. Kidney involvement is usually benign and secondary to chronic tubular deposition of hemosiderin. Acute renal failure may occur in association with a hemolytic crisis. We report the case of a 70-year-old Caucasian woman with PNH who developed reversible acute renal failure requiring hemodialysis following a gastointestinal illness. Renal biopsy demonstrated acute tubular necrosis with considerable hemosiderin deposition, but no evidence of vascular thrombosis.
authors.affiliation: Department of Nephrology, Christchurch Hospital, New Zealand.
authors.forename: M D
authors.initials: MD
authors.lastname: Jose
authors.forename: K L
authors.initials: KL
authors.lastname: Lynn
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D000368:Aged; D003404:Creatinine / Q000097:blood; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000150:complications*; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications*; D006801:Humans; D007668:Kidney / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D006435:Renal Dialysis
chemical_list: D003404:Creatinine; D007770:L-Lactate Dehydrogenase