Age-dependent presence of antibodies in rat dams, capable of conferring protection against group B Streptococcus infection in neonates.
A rat model was used to investigate maternal age-dependent resistance on group B Streptococcus (GBS)-induced mortality of the offspring. Offspring from young (first time) or older (repeat litters) dams were challenged with GBS. There was an approximate log difference in the dose of GBS required to cause identical levels of mortality in the two groups. The sera of the dams from both groups were analysed by whole-cell ELISA, and it was demonstrated that sera from the older dams possessed circulating IgG cross-reactive to GBS. Since IgG is transplacentally transferred, we conclude that this is the method of observed protection.
Moore
J C
JC
Microscience Ltd, Wokingaham, UK.
Muckett
P J
PJ
Hughes
M J
MJ
D000375:Aging / Q000097:blood / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn / Q000097:blood / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000097:blood / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008423:Maternal Age; D011247:Pregnancy; D051381:Rats; D013290:Streptococcal Infections / Q000097:blood / Q000276:immunology* / Q000401:mortality; D013292:Streptococcus agalactiae / Q000276:immunology* / Q000302:isolation & purification
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G