Development of Tc-99m labeled tropanes: TRODAT-1, as a dopamine transporter imaging agent.
Advances in the technetium chemistry have significantly enhanced the development of Tc-99m radiopharmaceuticals for clinical use. Efforts in designing novel Tc-99m labeled receptor or site-specific imaging agents using [Tc(v)O](+3)N(2)S(2) core have produced useful imaging agents for single photo emission computed tomography (SPECT). The success in developing Tc-99m TRODAT-1 for CNS dopamine transporters (DAT) serves as the first example of Tc-99m site-specific imaging of human brain. New innovative Tc-99m labeled site-specific agents are particularly suitable to develop simple and useful routine diagnostic procedures.
Kung
H F
HF
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Kunghf@sunmac.spect.upenn.edu
D000818:Animals; D001923:Brain Chemistry; D050483:Dopamine Plasma Membrane Transport Proteins; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000032:analysis*; D009419:Nerve Tissue Proteins; D015609:Organotechnetium Compounds / Q000378:metabolism; D019275:Radiopharmaceuticals; D013667:Technetium; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes / Q000378:metabolism*
D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C493214:SLC6A3 protein, human; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1; D013667:Technetium