title: Non-occlusive small bowel necrosis during gastric tube feeding: a case report.
abstract: Small bowel necrosis is known as a rare, but serious complication of jejunal tube feeding. We report a case of non-occlusive small bowel necrosis with gastric tube feeding. The patient had a moderate multiple trauma with head injury. Abdominal distension developed after several days of uneventful nasogastric tube feeding. At laparotomy patchy necrosis of the small bowel was found without signs of bowel obstruction or impaired mesenteric perfusion. The patient recovered after a prolonged ICU stay. In this case the large doses of clonidine, given due to an alcohol withdrawal syndrome, were suspected to be a major contributing factor to the development of the small bowel necrosis by impairing gut motility and mucosal perfusion. We conclude that, first, small bowel necrosis can occur after primarily uneventful enteral feeding, even with gastric feeding; second, clonidine can dramatically impair gastrointestinal function in critically ill patients by impairing gut motility and mucosal perfusion.
authors.affiliation: Klinik Beau-Site, Schänzlihalde 11, 3000 Bern, Switzerland. frey@herzzentrum-bern.ch
authors.forename: C
authors.initials: C
authors.lastname: Frey
authors.forename: J
authors.initials: J
authors.lastname: Takala
authors.forename: L
authors.initials: L
authors.lastname: Krähenbühl
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000009:adverse effects*; D003000:Clonidine / Q000009:adverse effects*; D004750:Enteral Nutrition / Q000009:adverse effects*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications / Q000209:etiology* / Q000473:pathology; D007413:Intestinal Mucosa / Q000098:blood supply / Q000187:drug effects; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D013375:Substance Withdrawal Syndrome / Q000150:complications / Q000188:drug therapy
chemical_list: D000316:Adrenergic alpha-Agonists; D003000:Clonidine