title: Findings on retinal topography and thickness mapping in age-related macular degeneration.
abstract: OBJECTIVE
  To report alterations in the retinal topography and thickness in typical cases of age-related macular degeneration (ARMD).
  
  
  METHODS
  An optical imaging system was applied to patients with ARMD with alterations in the retinal structures. The system generates a series of 20 optical section images that encompass a 2 mm x 2 mm retinal area. The optical sections are digitized and analyzed to provide topographic maps of the vitreo-retinal and chorio-retinal surfaces and the retinal thickness.
  
  
  RESULTS
  Retinal topography and thickness mapping in a normal eye corresponded to normal anatomy. Topographic mapping in a patient with confluent drusen indicated elevation of the vitreo-retinal surface. Retinal topography in a patient with retinal pigment epithelium detachment displayed localized elevation of the chorio-retinal surface. The thickness map in a patient with geographic atrophy of the retinal pigment epithelium revealed retinal thinning. In the patients with choroidal neovascularization, the vitreoretinal and chorio-retinal surfaces were elevated. The chorio-retinal surface map in a patient with evolving disciform scar displayed topographic variations corresponding to the fibrovascular tissue underlying the serous detachment.
  
  
  CONCLUSIONS
  Retinal topography and thickness mapping is useful for visualization and evaluation of pathologic alterations in retinal structures due to ARMD.
authors.affiliation: Department of Ophthalmology and Visual Sciences, UIC Eye Center, University of Illinois at Chicago, 60612, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Gieser
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: N P
authors.initials: NP
authors.lastname: Blair
authors.forename: M
authors.initials: M
authors.lastname: Shahidi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000175:diagnosis; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D012160:Retina / Q000473:pathology*; D015593:Retinal Drusen / Q000175:diagnosis; D014792:Visual Acuity