Http://C. elegans: mining the functional genomic landscape.
Caenorhabditis elegans is a powerful animal model for the study of functional genomics. The completed and well-annotated DNA sequence is available and a systematic study of gene function by RNA-interference-mediated knockdown of every gene is in progress. Full-genome DNA microarrays and DNA chips can be used to determine expression changes at different stages of development and in different mutant backgrounds, and a protein-interaction map based on the yeast two-hybrid approach is in progress. These high-capacity approaches to studying gene function will provide new insights into invertebrate and vertebrate biology.
Kim
S K
SK
Department of Developmental Biology, Stanford University Medical School, Stanford, California 94305, USA. kim@cmgm.stanford.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D015870:Gene Expression; D017238:Genes, Helminth; D016678:Genome; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic
D015801:Helminth Proteins