title: Effect of subtotal colectomy on gastric emptying of a solid meal in slow-transit constipation.
abstract: BACKGROUND
  Idiopathic slow-transit constipation is considered a panenteral disease in which patients may have delayed gastric emptying. The effects of total abdominal colectomy and ileorectal anastomosis on upper gut motility are unknown. The aim of this study was to evaluate gastric emptying in patients with idiopathic slow-transit constipation before and after subtotal colectomy.
  
  
  METHODS
  Gastric emptying of a solid meal was studied by scintigraphic technique in 11 patients with idiopathic slow-transit constipation. The total colonic transit time was more than 72 hours in all patients studied, with delay in transit in all segments of the colon. The gastric emptying test was repeated 3 to 6 months after total abdominal colectomy and ileorectal anastomosis in ten of these patients. Before and after surgery, patients filled out a questionnaire to record upper gut symptoms.
  
  
  RESULTS
  Solid gastric emptying was delayed (T1/2 > upper limit of normal) in 7 of 11 patients with idiopathic slow-transit constipation. Gastric emptying T1/2 was almost similar before and after surgery. Mean +/- standard deviation was 142 +/- 91 minutes before surgery and 146 +/- 67 minutes after surgery. Symptoms of vomiting and belching improved significantly after surgery. Symptoms of nausea, bloating, and pyrosis also decreased, but these changes failed to reach statistical significance.
  
  
  CONCLUSIONS
  Despite a reduction in upper gut symptoms, total abdominal colectomy and ileorectal anastomosis does not improve delayed gastric emptying in patients with idiopathic slow-transit constipation.
authors.affiliation: Department of Surgery, University Hospital Nijmegen, 6500 HB Nijmegen, the Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: Mollen
authors.forename: W P
authors.initials: WP
authors.lastname: Hopman
authors.forename: W J
authors.initials: WJ
authors.lastname: Oyen
authors.forename: H H
authors.initials: HH
authors.lastname: Kuijpers
authors.forename: M A
authors.initials: MA
authors.lastname: Edelbroek
authors.forename: J B
authors.initials: JB
authors.lastname: Jansen
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003082:Colectomy; D003106:Colon / Q000503:physiopathology; D003248:Constipation / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005746:Gastric Emptying / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011183:Postoperative Complications / Q000503:physiopathology*