title: Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system.
abstract: The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, ofloxacin, based on the concept of pH-triggered in situ gelation. Polyacrylic acid (Carbopol 940) was used as the gelling agent in combination with hydroxypropylmethylcellulose (Methocel E50LV) which acted as a viscosity enhancing agent. The developed formulation was therapeutically efficacious, stable, non-irritant and provided sustained release of the drug over an 8-h period. The developed system is thus a viable alternative to conventional eye drops.
authors.affiliation: Pharmaceutical Division, Department of Chemical Technology (Autonomous), University of Mumbai, Nathalal Parikh Marg, Matunga, 400 019, Mumbai, India.
authors.forename: B
authors.initials: B
authors.lastname: Srividya
authors.forename: R M
authors.initials: RM
authors.lastname: Cardoza
authors.forename: P D
authors.initials: PD
authors.lastname: Amin
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D004355:Drug Stability; D005123:Eye / Q000378:metabolism*; D005782:Gels; D006863:Hydrogen-Ion Concentration; D015242:Ofloxacin / Q000008:administration & dosage* / Q000737:chemistry; D014677:Pharmaceutical Vehicles; D012995:Solubility; D014783:Viscosity
chemical_list: D000890:Anti-Infective Agents; D005782:Gels; D014677:Pharmaceutical Vehicles; D015242:Ofloxacin