title: Characteristics of plasma extracellular SOD in burned patients.
abstract: The aim of this study was to examine three types of superoxide dismutase (SOD) in plasma after burns, and especially to clarify the characteristics of plasma extracellular SOD (EC-SOD) in burned patients. A total of 71 blood samples were collected from 18 patients on arrival, day 1, day 3 and day 5 after burns. We measured three types of SOD (Mn, Cu/Zn, EC) in plasma using ELISA, and the relationships among the three types of SOD concentrations were examined. We next analyzed the characteristics of plasma EC-SOD using stepwise multivariate regression analysis. Any plasma SOD isoenzyme concentration measured after burns was beyond the normal range and EC-SOD accounted for the major part of plasma SODs. EC-SOD and Cu/Zn-SOD were positively correlated, whereas Mn-SOD was not related to the other SODs. Also, plasma EC-SOD was significantly related to existence of inhalation injury, %TBSA and age, respectively. The plasma EC-SOD might therefore play some roles in the pathophysiology of burned patients.
authors.affiliation: Department of Traumatology and Critical Care Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Saitama, Japan. ds0711@me.ndmc.ac.jp
authors.forename: D
authors.initials: D
authors.lastname: Saitoh
authors.forename: T
authors.initials: T
authors.lastname: Ookawara
authors.forename: K
authors.initials: K
authors.lastname: Fukuzuka
authors.forename: M
authors.initials: M
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: H
authors.initials: H
authors.lastname: Ohno
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000328:Adult; D000368:Aged; D002056:Burns / Q000201:enzymology*; D002059:Burns, Inhalation / Q000201:enzymology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000097:blood*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D013997:Time Factors
chemical_list: D016166:Free Radical Scavengers; D007527:Isoenzymes; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase