The application of chiral aminonaphthols in the enantioselective addition of diethylzinc to aryl aldehydes.
[reaction: see text]. Optically active aminonaphthol 3 obtained by condensation of 2-naphthol, benzaldehyde, and (S)-methylbenzylamine followed by N-methylation was found to catalyze the enantioselective ethylation of aryl aldehydes to secondary alcohols with high enantioselectivities (up to 99.8%) at room temperature.
Liu
D X
DX
Open Laboratory of Chirotechnology, Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, P. R. China. daxueliu@sohu.com
Zhang
L C
LC
Wang
Q
Q
Da
C S
CS
Xin
Z Q
ZQ
Wang
R
R
Choi
M C
MC
Chan
A S
AS