[Microsomal monooxygenases upon inhalation exposure to pseudocumene and durene].
This paper gives data on the levels of cytochromes of B5, P450, P420, P450 + P420, on the rates of amidopyrinum N-demethylation and aniline n-hydroxylation in the tissues of the lung, liver, kidney of experimental rats upon acute and chronic (4-month) inhalation exposure to pseudocumol and durol at a concentration of 10 mg/m3. Acute and chronic inhalation exposures to the xenobiotics in this concentration result in activation of microsomal monooxygenases in the tissues of experimental rats in relation to the type of exposure.
Shakirov
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D000818:Animals; D001555:Benzene Derivatives / Q000633:toxicity*; D003580:Cytochromes / Q000378:metabolism; D006900:Hydroxylation; D019570:Inhalation Exposure; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008745:Methylation; D008861:Microsomes / Q000187:drug effects* / Q000201:enzymology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D013997:Time Factors; D015262:Xenobiotics / Q000378:metabolism
D001555:Benzene Derivatives; D003580:Cytochromes; D015262:Xenobiotics; C023973:durene; C010313:pseudocumene
Sostoianie mikrosomal'nykh monooksigenaz pri ingaliatsionnom vozdeĭstvii psevdokumola i durola.