title: [Detection of the cholinesterase inhibitor tacrine and its main metabolites].
abstract: Tacrine, a cholinesterase inhibitor for symptomatic treatment of minor to moderate dementia, and its primary metabolites 1-hydroxy-tacrine and 4-hydroxy-tacrine were studied by means of thin-layer chromatography, UV spectroscopy and gas-chromatography/mass spectroscopy. The analytical data (corrected hRf values, UV spectra in solution as well as reflectance spectra, high-pressure liquid chromatography data, GC retention indices and EI mass spectra) including various derivatization methods are described.
authors.affiliation: Instituten für Rechtsmedizin der Universitäten Giessen.
authors.forename: H
authors.initials: H
authors.lastname: Schütz
authors.forename: B
authors.initials: B
authors.lastname: Ahrens
authors.forename: F
authors.initials: F
authors.lastname: Erdmann
authors.forename: G
authors.initials: G
authors.lastname: Weiler
mesh_terms: D001711:Biotransformation; D002800:Cholinesterase Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D008657:Metabolic Clearance Rate; D013329:Structure-Activity Relationship; D013619:Tacrine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*
chemical_list: C092548:2-hydroxytacrine; C092547:4-hydroxytacrine; D002800:Cholinesterase Inhibitors; D013619:Tacrine; C056424:velnacrine
vernacular_title: Nachweis des Cholinesterasehemmers Tacrin und seiner Hauptmetaboliten.