Investigation of follicular penetration of topically applied substances.
The influence of specific follicle properties, sebum production and hair growth on the follicular penetration of topically applied substances was investigated. The behavior of follicles identified in selected skin areas of volunteers was analyzed by various tape stripping and staining methods in combination with laser scanning microscopy. Furthermore hair growth in the selected skin areas was determined. A correlation between sebum production, hair growth activity and follicular penetration was observed.
Lademann
J
J
Center of Experimental and Applied Cutaneous Physiology, Dermatological Clinic, Medical Faculty Charité, Humboldt University, Berlin, Germany. juergen.lademann@charite.de
Otberg
N
N
Richter
H
H
Weigmann
H J
HJ
Lindemann
U
U
Schaefer
H
H
Sterry
W
W
D000287:Administration, Topical; D004396:Coloring Agents; D003487:Cyanoacrylates; D006197:Hair / Q000254:growth & development; D018859:Hair Follicle / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008856:Microscopy, Fluorescence; D009993:Osmium Tetroxide; D012629:Sebum / Q000378:metabolism; D012869:Skin Absorption / Q000502:physiology*
D004396:Coloring Agents; D003487:Cyanoacrylates; D009993:Osmium Tetroxide