title: Atrial thrombus and central venous dialysis catheters.
abstract: A native arteriovenous fistula is the first choice for hemodialysis access. Despite improved catheter designs and the use of internal jugular veins, thrombotic complications still occur when tunneled central venous catheters are used as an alternative. Although right atrial thrombus (RAT) is a well-characterized complication of long-term central venous cannulation, particularly when used for parenteral nutrition and chemotherapy in pediatric practice, only 9 reported cases previously have been associated with the long-term use of central venous catheters for hemodialysis. We report five cases of RAT seen at our unit between 1994 and 1998 in patients who had been dialyzed using tunneled catheters. In four of five cases, the diagnosis was made during the investigation of hemoptysis or dyspnea. In the fifth case, a screening transthoracic echocardiogram revealed the thrombus. Three of five of the patients suffered pulmonary emboli, and a fourth patient had an unexplained electromechanical dissociation cardiac arrest without definite evidence of pulmonary embolus. Our experience suggests that anticoagulated patients with RAT remain at risk of pulmonary embolism. One of our patients successfully underwent atrial thrombectomy. In four of five of our cases and four of nine cases in the literature, the central venous catheter tip was within the right atrium. Positioning of the central venous catheter tip low down in the superior vena cava or in the right atrium has been advocated to improve dialysis adequacy and to reduce the incidence of catheter thrombosis. However, placement of the catheter tip within the right atrium may be associated with an increased risk of RAT.
authors.affiliation: Centre for Nephrology, and Department of Cardiology, Royal Free and University College Medical School, University College London, United Kingdom. kingdon@rfc.ucl.ac.uk
authors.forename: E J
authors.initials: EJ
authors.lastname: Kingdon
authors.forename: S G
authors.initials: SG
authors.lastname: Holt
authors.forename: J
authors.initials: J
authors.lastname: Davar
authors.forename: D
authors.initials: D
authors.lastname: Pennell
authors.forename: R A
authors.initials: RA
authors.lastname: Baillod
authors.forename: A
authors.initials: A
authors.lastname: Burns
authors.forename: P
authors.initials: P
authors.lastname: Sweny
authors.forename: A
authors.initials: A
authors.lastname: Davenport
mesh_terms: D000293:Adolescent; D000328:Adult; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D017548:Echocardiography, Transesophageal; D017809:Fatal Outcome; D005260:Female; D006325:Heart Atria; D006331:Heart Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects / Q000295:instrumentation; D006435:Renal Dialysis / Q000295:instrumentation*; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology