title: [A case of Churg-Strauss syndrome in which positive rheumatoid factor and MPO-ANCA preceded the development of clinical symptoms of vasculitis].
abstract: A 52-year-old man in whom bronchial asthma had been diagnosed in 1995 was admitted for the treatment of Churg-Strauss syndrome in June 1997. Positive tests MPO-ANCA and rheumatoid factor preceded the symptoms of vasculitis for several months. A skin biopsy revealed infiltration of eosinophils in the vessel walls, and the diagnosis of Churg-Strauss syndrome was confirmed. After systemic administration of corticosteroids, the symptoms other than mononeuritis improved markedly, and his MPO-ANCA and rheumatoid factor became negative. Rheumatoid factor and MPO-ANCA may be useful for the early diagnosis of Churg-Strauss syndrome in patients with bronchial asthma in which a well-controlled disease develops into an intractable condition.
authors.affiliation: Department of Pulmonary Medicine, Tokyo Medical and Dental University.
authors.forename: M
authors.initials: M
authors.lastname: Furuiye
authors.forename: K
authors.initials: K
authors.lastname: Konno
authors.forename: Y
authors.initials: Y
authors.lastname: Sumi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtani
authors.forename: M
authors.initials: M
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Umino
authors.forename: N
authors.initials: N
authors.lastname: Inase
authors.forename: S
authors.initials: S
authors.lastname: Miyake
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshizawa
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015267:Churg-Strauss Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000276:immunology; D011239:Prednisolone / Q000008:administration & dosage; D012217:Rheumatoid Factor / Q000097:blood*; D013997:Time Factors
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D012217:Rheumatoid Factor; D011239:Prednisolone; D009195:Peroxidase