[A comparative analysis of changes in immune homeostasis in laparoscopic and conventional surgical interventions on the large intestine].
A comprehensive evaluation has been done of parameters characterizing cell-bound immunity, cytokinic profile, stress hormones (hydrocortisone), and C-reactive protein in a comparative aspect in those patients having undergone laparoscopic or conventional colectomy. The above indices were determined before surgery, in the early postoperative period, 24 h and 7 days subsequent to surgery. Laparoscopic surgical intervention was found out to lower somewhat the level of immunosuppression early in the postoperative course, which fact is manifested by retaining of expression HLA-DR on monocytes of the peripheral blood. Further randomized investigations should allow the final judgement about the degree of surgical stress.
Kucher
M D
MD
Kriuchyna
Ie A
IeA
Norwood
V
V
Harrison
K
K
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D003082:Colectomy; D016207:Cytokines / Q000097:blood; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007410:Intestinal Diseases / Q000276:immunology* / Q000601:surgery; D007420:Intestine, Large / Q000276:immunology* / Q000601:surgery; D010535:Laparoscopy; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors
D016207:Cytokines; D006684:HLA-DR Antigens; D002097:C-Reactive Protein; D006854:Hydrocortisone
Porivnial'nyĭ analiz zmin imunnoho homeostazu pry laparoskopichnykh ta tradytsiĭnykh operatyvnykh vtruchanniakh na tovstiĭ kyshtsi.