title: Evaluation of toxicity of some saponins on brine shrimp.
abstract: Toxicity of several types of saponins (1-11) against brine shrimp (Artemia salina) were evaluated. As a result, it was found that most tested compounds were not toxic to brine shrimp at high enough concentration. The most toxic saponin (1) to brine shrimp showed also cytotoxicity towards HL-60 tumor cell line using MTT assay. Brine shrimp model may thus be used as bench-top assay in finding cytotoxic components from saponin-containing fractions of plant extracts.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences. wmzhao@mail.shcnc.ac.cn
authors.forename: W M
authors.initials: WM
authors.lastname: Zhao
authors.forename: G W
authors.initials: GW
authors.lastname: Qin
authors.forename: L G
authors.initials: LG
authors.lastname: Lou
mesh_terms: D000818:Animals; D033364:Decapoda / Q000187:drug effects*; D018922:HL-60 Cells; D006801:Humans; D012503:Saponins / Q000633:toxicity*
chemical_list: D012503:Saponins