title: Reduced prevalence of serum antibodies against adeno-associated virus type 2 in patients with adult T-cell leukaemia lymphoma.
abstract: Seroepidemiological studies have shown previously that cancer patients are less likely to have antibodies against the tumour suppressive adeno-associated virus (AAV) than control groups. To examine the influence of AAV infection on the development of adult T-cell leukaemia lymphoma (ATLL), an endemic disease in Southern Japan that is caused by infection with the human T-cell leukaemia virus type 1 (HTLV-I), the prevalence of serum antibodies to AAV type 2 (AAV-2) was tested in healthy HTLV-I carriers (n = 39) and patients with ATLL (n = 31). The results showed a significant difference in AAV-2 seropositivity between the two groups: Only 29% of the ATLL patients had IgG antibodies against AAV-2, whereas 84.6% of the healthy HTLV-I carriers were seropositive. Analysis of total serum IgG and antibodies against the Epstein-Barr virus (EBV) EBNA1 antigen showed that the lack of AAV antibodies in patients was not due to an ATLL-associated immune deficiency. The lower level of AAV-2 seropositivity in ATLL-patients may indicate that AAV-2 antibody-positive HTLV-I carriers might be less likely to develop ATLL or that loss of AAV-2 antibodies may parallel the development of disease.
authors.affiliation: Angewandte Tumorvirologie F0100, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld, Heidelberg, Germany.
authors.forename: C M
authors.initials: CM
authors.lastname: Walz
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Fukunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Jasiewicz
authors.forename: L
authors.initials: L
authors.lastname: Edler
authors.forename: J R
authors.initials: JR
authors.lastname: Schlehofer
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D002353:Carrier State; D000229:Dependovirus / Q000276:immunology*; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology* / Q000821:virology; D008297:Male; D010322:Parvoviridae Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D015995:Prevalence; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G