Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint.
Bioassay-guided fractionation of the organic extract from a culture of Phomopsis longicolla, an endophytic fungus of the endangered mint Dicerandra frutescens, led to the isolation of dicerandrols A, B, and C. Extensive NMR and HRFABMS experiments were used to identify these new yellow antibiotic and cytotoxic compounds as 2,2'-dimeric tetrahydroxanthones.
Wagenaar
M M
MM
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, USA.
Clardy
J
J
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D003110:Colonic Neoplasms; D005431:Florida; D005848:Geotrichum / Q000187:drug effects; D006801:Humans; D019686:Lamiaceae; D008175:Lung Neoplasms; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones
D000903:Antibiotics, Antineoplastic; D014966:Xanthenes; D044004:Xanthones; C436329:dicerandrol A; C436330:dicerandrol B; C436331:dicerandrol C; C009218:secalonic acid