REST acts through multiple deacetylase complexes.
The RE1 binding silencer protein REST represses neuronal-specific gene expression in nonneuronal cell types. In this issue of Neuron, Ballas et al. show that REST inhibits gene expression via the recruitment of multiple histone deacetylase complexes.
Griffith
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EC
Division of Neuroscience, Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Cowan
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CW
Greenberg
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ME
D000581:Amidohydrolases / Q000378:metabolism*; D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D020868:Gene Silencing; D009474:Neurons / Q000502:physiology*; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000378:metabolism*; D013116:Spinal Cord / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D016335:Zinc Fingers; D000099229:RE1-Silencing Transcription Factor
D000581:Amidohydrolases; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D000099229:RE1-Silencing Transcription Factor