Separase anxiety: dissolving the sister bond and more.
Separase is a protease that cleaves the bonds between sister chromatids during cell division. Until now, separase was thought to be a somewhat repressed protease, cleaving only a few substrates in a very controlled fashion. New findings in this issue raise the possibility that separase has some of the atavistic impulses that characterize caspases, its more destructive relatives.
Pellman
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Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. david_pellman@dfci.harvard.edu
Christman
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MF
D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002455:Cell Division; D002842:Chromatids / Q000235:genetics / Q000378:metabolism*; D010450:Endopeptidases; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D064247:Separase
D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins; D010450:Endopeptidases; C577986:ESP1 protein, S cerevisiae; D064247:Separase