Accelerated atheroma, antiphospholipid antibodies, and the antiphospholipid syndrome.
Indirect data coming from animal studies and in vitro observations support the contention that the mere presence of antiphospholipid antibodies may be sufficient to increase atheroma development, regardless of other predisposing factors. It seems that humoral and cellular immune responses to beta 2-glycoprotein I can play an important role in mediating the increased propensity to atherosclerosis.
George
J
J
Department of Cardiology, Tel Aviv Medical Center, Tel Aviv, Israel.
Haratz
D
D
Shoenfeld
Y
Y
D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000276:immunology* / Q000503:physiopathology; D001161:Arteriosclerosis / Q000503:physiopathology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology
D017152:Antibodies, Antiphospholipid; D019038:Platelet Glycoprotein GPIb-IX Complex