title: Impact of certain flavonoids on lipid profiles--potential action of Garcinia cambogia flavonoids.
abstract: Flavonoids from Cocos nucifera, Myristica fragrance, Saraka asoka and Garcinia cambogia exerted hypolipidaemic activity in rats. Lipid lowering activity was maximum in rats administered flavonoids (10 mg/kg BW/day) from Garcinia cambogia. A dose response study revealed biphasic activity. Higher doses were less effective in reducing lipid levels in serum and tissues, although devoid of toxic effects.
authors.affiliation: Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram-695581, India.
authors.forename: A S
authors.initials: AS
authors.lastname: Koshy
authors.forename: N R
authors.initials: NR
authors.lastname: Vijayalakshmi
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D019685:Rosales; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
chemical_list: D005419:Flavonoids; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol