title: Pulmonary haemorrhage in a 6-year-old boy with Henoch-Schönlein purpura.
abstract: Henoch-Schönlein purpura (HSP) is the most common vasculitis in children. It is a multisystemic disease but pulmonary haemorrhage is extremely rare. We present the case of a 6-year-old boy with Henoch-Schönlein purpura, pulmonary haemorrhage and severe renal involvement. The patient responded to a combination of intravenous methylprednisolone and cyclophosphamide. A review of the literature revealed that young age may be a good prognostic sign and that immunosuppressive drugs and supportive management are essential in the treatment. Renal biopsy is helpful in the differential diagnosis of HSP-mimicking pulmonary vasculitic syndromes. Combining cyclophosphamide with glucocorticoids may improve the outcome in severe HSP cases with pulmonary haemorrhage.
authors.affiliation: Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Besbas
authors.forename: A
authors.initials: A
authors.lastname: Duzova
authors.forename: R
authors.initials: R
authors.lastname: Topaloglu
authors.forename: F
authors.initials: F
authors.lastname: Gok
authors.forename: F
authors.initials: F
authors.lastname: Ozaltin
authors.forename: S
authors.initials: S
authors.lastname: Ozen
authors.forename: A
authors.initials: A
authors.lastname: Bakkaloglu
mesh_terms: D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D007262:Infusions, Intravenous; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D003520:Cyclophosphamide; D008775:Methylprednisolone