[Towards a cell therapy for diabetes? An epistemiological perspective].
This text describes, in an epistemological perspective, the development of the concept of cellular therapy applied to the treatment of type 1 diabetes. Emphasis is put on three recent papers describing the success of islet allograft in diabetic patients, the development of neo-islets from stem cells isolated from the pancreas of adult mice, and the effect of hepatic cell transfection with an adenovirus bearing the gene coding for PDX-1, a transcription factor involved in the maturation of islets of Langerhans. This text tries to delineate some factors which may be involved in the chances for these techniques to reach the real world of human therapeutics.
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INSERM U341, Service de Diabétologie, Hôtel-Dieu, 1, Place du Parvis Notre Dame, 75404 Paris.
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D002478:Cells, Cultured / Q000378:metabolism / Q000637:transplantation; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000266:history / Q000628:therapy*; D004992:Ethics, Medical; D005822:Genetic Vectors; D049672:History, 19th Century; D049673:History, 20th Century; D018398:Homeodomain Proteins; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000627:therapeutic use; D000078790:Insulin Secretion; D016381:Islets of Langerhans Transplantation / Q000266:history; D008099:Liver / Q000166:cytology; D010179:Pancreas / Q000166:cytology; D016035:Pancreas Transplantation / Q000266:history; D011993:Recombinant Fusion Proteins / Q000502:physiology; D013234:Stem Cells / Q000166:cytology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D014162:Transfection; D014183:Transplantation, Heterologous
D018398:Homeodomain Proteins; D007328:Insulin; D011993:Recombinant Fusion Proteins; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein
Vers une thérapie cellulaire du diabète? Une perspective épistémologique.