Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1.
The study of green tea polyphenols as a cancer preventative is approaching a new era, with significant results accumulating rapidly. This paper briefly reviews four topics related to mechanisms of action of tea polyphenols: (I) identification of the genes commonly affected by EGCG, as demonstrated by Clontech's Atlas cDNA Expression Array; (II) the significance of heterogeneous nuclear ribonucleoprotein B1 (hnRNP B1) as a new biomarker for early detection of lung cancer, and inhibition of its expression by EGCG; (III) the synergistic or additive effects of EGCG with the cancer preventive agents, sulindac and tamoxifen, on induction of apoptosis in PC-9 cells and on inhibition of intestinal tumor development in multiple intestinal neoplasia (Min) mice; (IV) the results of a 10 year prospective cohort study demonstrating the effectiveness of daily consumption of green tea in preventing cancer, and a prototype study for developing green tea beverage as cancer preventive.
Fujiki
H
H
Saitama Cancer Center, Ina, Kitaadachi-gun, Saitama 362-0806, Japan. hfujiki@cancer-c.pref.saitama.jp
Suganuma
M
M
Okabe
S
S
Sueoka
E
E
Sueoka
N
N
Fujimoto
N
N
Goto
Y
Y
Matsuyama
S
S
Imai
K
K
Nakachi
K
K
D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage* / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000175:diagnosis / Q000517:prevention & control*; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry; D018890:Chemoprevention; D015331:Cohort Studies; D004357:Drug Synergism; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D007414:Intestinal Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control*; D007564:Japan; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D019319:Okadaic Acid / Q000494:pharmacology; D020411:Oligonucleotide Array Sequence Analysis; D011446:Prospective Studies; D012261:Ribonucleoproteins / Q000032:analysis*; D013467:Sulindac / Q000008:administration & dosage*; D013662:Tea / Q000737:chemistry; D014407:Tumor Cells, Cultured
D016588:Anticarcinogenic Agents; D014408:Biomarkers, Tumor; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012261:Ribonucleoproteins; D013662:Tea; C439768:hnRNP A2; D013467:Sulindac; D019319:Okadaic Acid; D002392:Catechin; C045651:epigallocatechin gallate