In vitro anti-Helicobacter pylori activity of panaxytriol isolated from ginseng.
This study investigated the effect that some polyacetylenes and protopanaxatriol, which were isolated from heated ginseng (family Araliaceae), have on inhibiting Helicobacter pylori (HP) growth. Among the compounds tested, panaxytriol was quite effective in inhibiting HP growth with an MIC of 50 microg/ml. Ginsenoside Rh1 and protopanaxatriol weakly inhibited H+/K+-ATPase from a rat stomach.
Bae
E A
EA
Department of Food and Nutrition, Kyung Hee University, Seoul, Korea.
Han
M J
MJ
Baek
N I
NI
Kim
D H
DH
D000480:Alkynes; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D053281:Enediynes; D005233:Fatty Alcohols / Q000302:isolation & purification / Q000494:pharmacology*; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D016480:Helicobacter pylori / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D008297:Male; D005894:Panax / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000187:drug effects / Q000201:enzymology / Q000382:microbiology; D014510:Urease / Q000378:metabolism
D000480:Alkynes; D000900:Anti-Bacterial Agents; D053281:Enediynes; D005233:Fatty Alcohols; C057682:panaxytriol; D014510:Urease; D017506:H(+)-K(+)-Exchanging ATPase