Levodopa induces dyskinesias in normal squirrel monkeys.
This study assessed whether or not levodopa induces dyskinesias in normal (ie, unlesioned) squirrel monkeys. All six animals treated twice daily with levodopa (15 mg/kg with carbidopa by oral gavage) for two weeks developed choreoathetoid dyskinesias, whereas none of the vehicle-treated animals displayed any abnormal movements. These dyskinesias did not merely reflect a generalized motor activation as locomotion was actually suppressed. The present data demonstrate that preexisting nigrostriatal damage is not necessary for the development of levodopa-induced dyskinesias.
Togasaki
D M
DM
The Parkinson's Institute, Sunnyvale, CA 94089, USA. dtogasaki@parkinsonsinstitute.org
Tan
L
L
Protell
P
P
Di Monte
D A
DA
Quik
M
M
Langston
J W
JW
D000818:Animals; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000503:physiopathology*; D007980:Levodopa / Q000009:adverse effects*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D012016:Reference Values; D012453:Saimiri
D007980:Levodopa