Pulmonary reactions during treatment with amphotericin B: review of published cases and guidelines for management.
Acute respiratory events occasionally have been observed during the infusion of amphotericin B. Herein we analyze the 21 cases that have been reported, including a fatal reaction observed by us. Some useful guidelines are provided that likely will allow treatment to be continued safely for patients who have experienced such reactions.
Collazos
J
J
Section of Infectious Diseases, Hospital de Galdakao, Vizcaya, Spain. jcollazos@hgda.osakidetza.net
Martínez
E
E
Mayo
J
J
Ibarra
S
S
D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D008297:Male; D009181:Mycoses / Q000188:drug therapy*; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000009:adverse effects*; D010715:Phosphatidylglycerols / Q000008:administration & dosage / Q000009:adverse effects*
D000935:Antifungal Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D000666:Amphotericin B