Aquaporins and the surgeon: cautionary tales.
Nephrogenic diabetes insipidus (NDI) presents an uncommon but formidable clinical challenge in the surgical patient. Two recent cases of NDI with differing aetiology are presented. These cases and a review of the literature illustrate well the diagnosis, fluid and electrolyte imbalances seen and the strategy of treatment required in the post-operative setting. The central role of the recently discovered aquaporin channels in this condition is briefly outlined. Nephrogenic diabetes insipidus has a diverse aetiology and many of the hazards of the condition are peculiar to the surgical setting. The importance of management in a high dependency environment is highlighted.
Shaw
R J
RJ
Surgical High Dependency Unit, Royal Alexandra Hospital, Paisley, UK. richardjohnshaw@hotmail.com
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D020346:Aquaporins / Q000378:metabolism*; D003082:Colectomy / Q000009:adverse effects; D018500:Diabetes Insipidus, Nephrogenic / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D005260:Female; D016575:Hidradenitis / Q000601:surgery*; D006801:Humans; D007813:Laparotomy / Q000009:adverse effects; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D018570:Risk Assessment; D012307:Risk Factors
D020346:Aquaporins; D016651:Lithium Carbonate