Long-term exposures to higher environmental temperature and body temperature: effect of chlorpromazine in relation to hypothalamic GABA.
Treatment with a single dose of chlorpromazine (CPZ; 1 mg/kg, ip) at room temperature (28 degrees +/-0.5 degrees C) significantly reduced body temperature by its anticholinergic action. Long-term exposures to higher environmental temperature (40 degrees +/-0.5 degrees C, 2 h/day, for 30 consecutive days) increased body temperature significantly by reduction of hypothalamic GABAergic activity, but this increase in body temperature was attenuated from that observed with a single exposure to higher environmental temperature (40 degrees C for 2 h). Treatment with a single dose of CPZ on the last day of 30 consecutive days of exposures to higher environmental temperature increased body temperature of rats more than that observed with long-term exposures to higher environmental temperature possibly due to (i) reduction of hypothalamic GABAergic activity, (ii) heat dissipation and (iii) reverse-anticholinergic action of CPZ at higher environmental temperature.
Mukherjee
D
D
Department of Biochemistry, College of Science, University of Calcutta, 35 Ballygunge Circular Road, Calcutta 700 019, India.
Poddar
M K
MK
D000818:Animals; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology; D002746:Chlorpromazine / Q000494:pharmacology*; D018679:Cholinergic Agonists / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004781:Environmental Exposure; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D006358:Hot Temperature; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018679:Cholinergic Agonists; D018680:Cholinergic Antagonists; D018492:Dopamine Antagonists; D018755:GABA Agonists; D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid; D002746:Chlorpromazine