Administration of chinese herbal medicines facilitates the locomotor activity in dystrophin-deficient mice.
The purpose of this study was to access the effects of chinese herbal medicines on Duchenne muscular dystrophy (DMD). We use dystrophin-deficient mice (mdx), an animal model of DMD, to evaluate the effect of chinese herbal medicines on locomotor activity. The consumption of water for each mouse was controlled during the three-month experimental session. Each mouse was allowed to drink 3 ml water with or without herbal medicines daily for three months. The estimated intake of chinese herbal medicine in adult mdx mouse with 30 g weight is 100 mg/kg per day, close to a dose used in human. The locomotor activity of the mdx mice was measured every month. Monitoring the locomotor activity of mdx mice after three-month administration of chinese herbal medicines, the results showed that liu-wei-di-huang-wan (LDW) and san-lin-pai-tsu-san (SPS) can facilitate locomotor activity with the parameters of horizontal activity, total distance, number of movements, movement time, vertical activity, number of vertical movements, vertical movement time, stereotypy, number of stereotyped movements, and stereotyped movement time. These results suggest that either LDW or SPS can act as a potent herbal medicine for the pharmacological treatment of DMD patients.
Chen
S S
SS
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Taiwan.
Wang
D C
DC
Chen
T J
TJ
Yang
S L
SL
D000704:Analysis of Variance; D000818:Animals; D018450:Disease Progression; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016189:Dystrophin / Q000172:deficiency; D008297:Male; D051379:Mice; D018101:Mice, Inbred mdx; D023421:Models, Animal; D009043:Motor Activity / Q000187:drug effects; D009068:Movement / Q000187:drug effects*; D018908:Muscle Weakness / Q000517:prevention & control; D020388:Muscular Dystrophy, Duchenne / Q000188:drug therapy* / Q000503:physiopathology; D011788:Quality of Life; D013997:Time Factors; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D016189:Dystrophin