[Hyperfluorescent areas observed in late-phase indocyanine green angiography (IA) of IA findings in fellow eyes of unilateral age-related macular degeneration].
OBJECTIVE
To evaluate abnormal findings of indocyanine green angiography (IA), predisposing to exudative age-related macular degeneration (AMD) in fellow eyes of unilateral exudative AMD.


METHODS
We categorized 83 fellow eyes of unilateral exudative AMD into two groups, i.e. 55 eyes with early age-related maculopathy, and 28 eyes with normal aging. We performed IA.


RESULTS
The late phase of IA demonstrated hyperfluorescent areas in 27 of the 83 fellow eyes, which included 22 of the 55 eyes with early age-related maculopathy and five eyes of 28 eyes with normal aging. The prevalence of the late-phase hyperfluorescence was statistically significant in early age-related maculopathy. Eight of the 22 eyes with early age-related maculopathy and one of the five eyes with normal aging progressed to exudative AMD.


CONCLUSIONS
Hyperfluorescent areas observed in late-phase IA before the manifestation of exudative AMD suggested the possible presence of choroidal neovascular membrane in the subretinal pigment epithelial space.
Haruyama
M
M
Department of Ophthalmology, Surugadai Hospital of Nihon University, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo 101-8039, Japan.
Yuzawa
M
M
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D004396:Coloring Agents; D007208:Indocyanine Green