Effects of lisinopril on streptozotocin-induced diabetic neuropathy in rats.
Streptozotocin (STZ)-induced diabetic neuropathy in rats was monitored by measuring the motor nerve conduction velocity (MNCV) and histopathology of the tibial nerve. Pretreatment with lisinopril (2 mg/kg p.o., 5 days prior to STZ and continued for 10 weeks) significantly (p < 0.01) prevented deterioration of MNCV as compared to STZ-diabetic animals. Nerve sections from the lisinopril pretreated group revealed less structural damage as compared to STZ-diabetic rats. However lisinopril had no effect on blood sugar, i.e., it did not alter the diabetic state. It is concluded that lisinopril prevents the development of experimental diabetic neuropathy in STZ-induced diabetic rats.
Aggarwal
M
M
Departments of Pharmacology, Physiology and Pathology, Post Graduate Institute of Medical Sciences, Rohtak, India. monicag@rediffmail.com
Singh
J
J
Sood
S
S
Arora
B
B
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D004558:Electric Stimulation; D005260:Female; D007328:Insulin / Q000494:pharmacology; D017706:Lisinopril / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009046:Motor Neurons / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000503:physiopathology; D013979:Tibial Nerve / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D017706:Lisinopril