fMRI response during visual motion stimulation in patients with late whiplash syndrome.
After whiplash trauma, up to one fourth of patients develop chronic symptoms including head and neck pain and cognitive disturbances. Resting perfusion single-photon-emission computed tomography (SPECT) found decreased temporoparietooccipital tracer uptake among these long-term symptomatic patients with late whiplash syndrome. As MT/MST (V5/V5a) are located in that area, this study addressed the question whether these patients show impairments in visual motion perception. We examined five symptomatic patients with late whiplash syndrome, five asymptomatic patients after whiplash trauma, and a control group of seven volunteers without the history of trauma. Tests for visual motion perception and functional magnetic resonance imaging (fMRI) measurements during visual motion stimulation were performed. Symptomatic patients showed a significant reduction in their ability to perceive coherent visual motion compared with controls, whereas the asymptomatic patients did not show this effect. fMRI activation was similar during random dot motion in all three groups, but was significantly decreased during coherent dot motion in the symptomatic patients compared with the other two groups. Reduced psychophysical motion performance and reduced fMRI responses in symptomatic patients with late whiplash syndrome both point to a functional impairment in cortical areas sensitive to coherent motion. Larger studies are needed to confirm these clinical and functional imaging results to provide a possible additional diagnostic criterion for the evaluation of patients with late whiplash syndrome.
Freitag
P
P
Department of Neuroradiology, University Hospital Basel, Switzerland. pfreitag@uhbs.ch
Greenlee
M W
MW
Wachter
K
K
Ettlin
T M
TM
Radue
E W
EW
D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000033:anatomy & histology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009039:Motion Perception / Q000502:physiology*; D009778:Occipital Lobe / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology; D010468:Perceptual Disorders / Q000175:diagnosis; D011581:Psychological Tests; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000503:physiopathology; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology*; D014911:Whiplash Injuries / Q000175:diagnosis* / Q000503:physiopathology*