title: [Uncoupling proteins].
abstract: Uncoupling proteins are located in the inner mitochondria membrane. Their name is derived from their function: they uncouple oxidative procesess of the respiratory chain from ATP synthesis. Hitherto several members of the family have been described, the best known being UCP1. UCP1 can be expressed exclusively in brown adipose tissue and it is responsible for the heat production. In humans the brown fat disappears during the early childhood. In adults another members of the UCP family can be found--UCP2 and UCP3. It is widely accepted that these proteins affect lipid metabolism and energy expenditure. They are intensively studied owing to their possible use in the therapy of obesity. However, their physiological function has not been yet fully established.
authors.affiliation: Centrum pro diagnostiku a lécbu obezity III. interní kliniky 1. LF UK a VFN, Praha. mikulova@email.cz
authors.forename: R
authors.initials: R
authors.lastname: Mikulová
authors.forename: V
authors.initials: V
authors.lastname: Hainer
mesh_terms: D002001:Adipose Tissue, Brown / Q000502:physiology; D000818:Animals; D001833:Body Temperature Regulation; D002352:Carrier Proteins / Q000502:physiology*; D004734:Energy Metabolism; D006801:Humans; D007473:Ion Channels; D050356:Lipid Metabolism; D008565:Membrane Proteins / Q000502:physiology*; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011506:Proteins / Q000502:physiology*; D014475:Uncoupling Agents / Q000378:metabolism*; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3
chemical_list: D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; C000604371:UCP1 protein, human; C000604389:UCP2 protein, human; C000604392:UCP3 protein, human; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3
vernacular_title: Uncoupling proteiny.