title: Cytotoxic coumarins and lignans from extracts of the northern prickly ash (Zanthoxylum americanum).
abstract: Four pyranocoumarins; dipetaline, alloxanthoxyletin, xanthoxyletin and xanthyletin; and two lignans; sesamin and asarinin were isolated from the northern prickly ash, Zanthoxylum americanum. To varying degrees, all inhibited the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. Dipetaline was the most active with an IC(50) of 0.68 ppm, followed by alloxanthoxyletin (1.31 ppm), sesamin (2.71 ppm), asarinin (4.12 ppm), xanthoxyletin (3.48 ppm) and xanthylletin (3.84 ppm).
authors.affiliation: Department of Plant Science, Cook College, Rutgers University, New Brunswick, NJ 08903, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Ju
authors.forename: C C
authors.initials: CC
authors.lastname: Still
authors.forename: J N
authors.initials: JN
authors.lastname: Sacalis
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: C T
authors.initials: CT
authors.lastname: Ho
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000517:prevention & control*; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018547:Plant Stems; D010946:Plants, Medicinal; D019685:Rosales
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D017705:Lignans; D010936:Plant Extracts