[The role of beta-adrenoreceptors in pathogenesis of neurogenic dystrophies].
Sciatic nerve damage led to a defective functioning of the renal mineralocorticoid receptors due to the disturbed neurotrophic supply of this organ: the reception of distorted nervous stimuli. The pharmacological blockade of both the neurotransmitter and the humoral pathways of the pathological stimuli from the damaged nerve to the kidney prevented the development of trophic disturbances as tested by the state of the renal mineralocorticoid receptor system. At the same time, the pharmacological stimulation of the sympathetic nervous system leads to an even more defective aldosterone reception by the kidney. Propranolol exerted an antidystrophic effect in the case of local damages of the nervous system and, thereby, prevented the development of neurogenic dystrophies.
Akimov
Iu A
IuA
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Butlerova 5A, Moscow, 117865 Russia.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D003714:Denervation; D007668:Kidney / Q000294:innervation* / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D018161:Receptors, Mineralocorticoid / Q000502:physiology*; D020426:Sciatic Neuropathy / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone; D011433:Propranolol
O roli beta-adrenoretseptorov organizma v mekhanizmakh razvitiia neĭrogennykh distrofiĭ.