[Effect of Xue Zhi Kang on the formation of fatty liver in cholesterol-fed rabbits].
OBJECTIVE
To explore the effect of Xue Zhi Kang (XZhK) on the formation of fatty liver in cholesterol-fed rabbits.


METHODS
XZhK was refined from Chinese traditional medicine Hong Qu and its main composition is HMG-CoA reductase inhibitor. Thirty New Zealand white rabbits were randomly assigned into 3 groups (control, hypercholesterol-fed, and XZhK groups) during the 12 week's experiment. The effects of XZhK (0.8g.kg(-1).d(-1)) were investigated in rabbits fed a l.5% cholesterol diet. The changes of serum TC, TG, HDL-C, and LDL-C concentrations and the histopathological changes of the liver were detected.


RESULTS
The serum TC, LDL-C, and TG levels decreased in XZhK group compared with those in the cholesterol-fed control group (P<0.05 ). The serum HDL-C concentration slightly increased, but there was no statistical significance. The fatty degeneration of liver was ameliorated in XZhK group (P<0.05).


CONCLUSIONS
XZhK can modulate the lipid metabolism and inhibit the formation of fatty liver in cholesterol-fed rabbits.
Zhang
M
M
Department of Cardiology, the Central Affiliated Hospital, Shenyang Medical University, Shenyang 110024, China.
Tong
Y
Y
Zheng
X
X
Chen
Y
Y
D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D005234:Fatty Liver / Q000188:drug therapy*; D005260:Female; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008297:Male; D008516:Medicine, Chinese Traditional; D011817:Rabbits
D002791:Cholesterol, Dietary; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids