The Ising model in physics and statistical genetics.
Interdisciplinary communication is becoming a crucial component of the present scientific environment. Theoretical models developed in diverse disciplines often may be successfully employed in solving seemingly unrelated problems that can be reduced to similar mathematical formulation. The Ising model has been proposed in statistical physics as a simplified model for analysis of magnetic interactions and structures of ferromagnetic substances. Here, we present an application of the one-dimensional, linear Ising model to affected-sib-pair (ASP) analysis in genetics. By analyzing simulated genetics data, we show that the simplified Ising model with only nearest-neighbor interactions between genetic markers has statistical properties comparable to much more complex algorithms from genetics analysis, such as those implemented in the Allegro and Mapmaker-Sibs programs. We also adapt the model to include epistatic interactions and to demonstrate its usefulness in detecting modifier loci with weak individual genetic contributions. A reanalysis of data on type 1 diabetes detects several susceptibility loci not previously found by other methods of analysis.
Majewski
J
J
Laboratory of Statistical Genetics, The Rockefeller University, New York, NY, 10021, USA. majewski@complex.rockefeller.edu
Li
H
H
Ott
J
J
D000465:Algorithms; D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods* / Q000706:statistics & numerical data*; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D004843:Epistasis, Genetic; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008280:Magnetics; D016555:Matched-Pair Analysis; D008957:Models, Genetic; D015233:Models, Statistical; D009679:Nuclear Family; D012107:Research Design; D012984:Software
D005819:Genetic Markers