No evidence for dependence of early cortical auditory processing on dopamine D(2)-receptor modulation: a whole-head magnetoencephalographic study.
Magnetoencephalography (MEG) was used to determine the effect of neuroleptic challenge on brain responses in healthy subjects. In a double-blind, randomized, placebo-controlled, cross-over design study, the dopamine D(2) receptor antagonist haloperidol (2 mg) was given orally to 12 healthy volunteers. The middle-latency auditory evoked magnetic fields (MAEF) were recorded 3 h after administration of haloperidol or placebo with a whole-head 122-channel MEG. Haloperidol did not significantly affect MAEF responses. The dipole moments and source locations of the responses were not significantly influenced by haloperidol. These results suggest that dopamine D(2) receptors are not involved in the early phases of auditory cortical processing.
Kähkönen
S
S
BioMag Laboratory, Medical Engineering Centre, Helsinki University Central Hospital, P.O. Box 340, FIN-00029 Helsinki, Finland. seppo.kahkonen@helsinki.fi
Ahveninen
J
J
Pekkonen
E
E
Kaakkola
S
S
Huttunen
J
J
Peltonen
T
T
Ilmoniemi
R J
RJ
Jääskeläinen
I P
IP
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D001303:Auditory Cortex / Q000378:metabolism / Q000502:physiology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000378:metabolism*
D014150:Antipsychotic Agents; D017448:Receptors, Dopamine D2; D006220:Haloperidol