Allelic expression and interleukin-2 polymorphisms in multiple sclerosis.
We have investigated the association of two single nucleotide polymorphisms (SNPs) at positions -384 and 114 in the human interleukin-2 (hIL-2) with multiple sclerosis (MS). For two of the -384 genotypes (G/T, T/T), we observed an association with the susceptibility to secondary progressive (SP) course of MS (P=0.005 and P=0.013, respectively). Expression level differences of the IL-2 alleles (between one- and three-fold) were not attributable to the -384 promoter polymorphism. These data indicate for the first time the relevance of the il-2 gene locus in human MS and its possible involvement in other autoimmune diseases.
Matesanz
F
F
Department of Immunology and Cellular Biology, Instituto de Parasitología y Biomedicina "López Neyra", CSIC, C/Ventanilla 11, 18001, Granada, Spain.
Fedetz
M
M
Collado-Romero
M
M
Fernández
O
O
Guerrero
M
M
Delgado
C
C
Alcina
A
A
D017668:Age of Onset; D000483:Alleles; D005787:Gene Frequency; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D020528:Multiple Sclerosis, Chronic Progressive / Q000453:epidemiology / Q000235:genetics*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012016:Reference Values
D007376:Interleukin-2