Skin aging: postulated mechanisms and consequent changes in structure and function.
Aging is a complex process influenced by telomere shortening and damage to cellular DNA. New insights into age-associated decrements in DNA damage repair are reviewed. Age-associated gross, histologic, and functional cutaneous deficits are delineated. Different treatment options for aged skin are examined.
Yaar
M
M
Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Gilchrest
B A
BA
D000975:Antioxidants / Q000627:therapeutic use; D004249:DNA Damage; D004260:DNA Repair; D004032:Diet; D020249:Hormone Replacement Therapy; D006801:Humans; D006880:Hydroxy Acids / Q000627:therapeutic use; D007641:Keratolytic Agents / Q000627:therapeutic use; D015595:Skin Aging / Q000187:drug effects / Q000502:physiology*; D012907:Smoking / Q000009:adverse effects; D013473:Sunscreening Agents / Q000627:therapeutic use; D014212:Tretinoin / Q000627:therapeutic use
D000975:Antioxidants; D006880:Hydroxy Acids; D007641:Keratolytic Agents; D013473:Sunscreening Agents; D014212:Tretinoin