[Antiinflammatory effect of a topical corticosteroid: known brand versus generic drug].
In Mexico, the generic drug market is growing. Regarding topical corticosteroids, there are several preparations on the local market but their clinical efficacy has not been assessed in relation with the original brand name. Using as a model the fluocinolone acetonide cream, the purpose of this study was to evaluate the antiinflammatory effect of different preparations. A double-blind, vehicle-control essay was conducted causing irritation on five sites of the volar aspect of the forearm in twenty healthy volunteers using 10% aqueous sodium lauryl sulfate. On the same part of the forearm, the formulations tested were applied for a period of 4 days with visual score irritation readings at days 2 and 4. The analysis of the results showed that although one of the generic drugs is 80% less expensive than the brandname medication, the clinical response was not as good as the other preparations. This deserves consideration, as newer and more potent generic corticosteroids will be available on the Mexican market.
Castanedo-Cázares
J P
JP
Departamento de Dermatología, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosí, S.L.P., México.
Quistián-Galván
J
J
Torres-Alvarez
B
B
Torres-Ruvalcaba
A
A
Moncada
B
B
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003872:Dermatitis / Q000188:drug therapy*; D004311:Double-Blind Method; D016568:Drugs, Generic / Q000627:therapeutic use*; D005260:Female; D005446:Fluocinolone Acetonide / Q000627:therapeutic use*; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D008875:Middle Aged
D000893:Anti-Inflammatory Agents; D016568:Drugs, Generic; D005938:Glucocorticoids; D005446:Fluocinolone Acetonide
Estudio del efecto antiinflamatorio de un corticosteroide tópico: marca reconocida versus genéricos.