Role of adhesion molecules in activation signaling in T lymphocytes.
The T cell and antigen-presenting cell communicate to initiate an immune response through formation of an immunological synapse. This specialized cell-cell junction is compartmentalized into adhesion molecule and T cell receptor enriched regions or SMACs. Distinct signals seem to be generated in the T cell receptor and adhesion molecule-dominated regions. This review focuses on how these distinct signaling pathways may be integrated within the T cell to set thresholds for T cell activation, proliferation, and survival.
Dustin
M L
ML
Department of Pathology, Skirball Institute of Molecular Medicine, New York University School of Medicine, New York 10016, USA. dustin@saturn.med.nyu.edu
D000938:Antigen-Presenting Cells / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology*; D002450:Cell Communication; D002451:Cell Compartmentation; D002455:Cell Division; D002470:Cell Survival; D007365:Intercellular Junctions / Q000276:immunology; D008213:Lymphocyte Activation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D015815:Cell Adhesion Molecules