title: High-dose omeprazole in esophagitis with stenosis after surgical treatment of esophageal atresia.
abstract: The authors describe 4 children with recurrent stenosis and persistent esophagitis after secondary repair of a long gap esophageal atresia. They underwent an esophageal reconstruction by elongation of the lesser gastric curvature according to Schärli at the age of 11 to 14 months. All had esophagitis grade III to IV (Savary-Miller classification), esophageal stenosis, and failure to thrive. Effective treatment of the esophagitis and prevention of stenosis consisted in high doses of omeprazole (1.9 to 2.5 mg/kg/d). After this treatment, the need for esophageal dilatation disappeared, and nutritional status normalized.
authors.affiliation: Department of Pediatrics, University Hospital Ghent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Van Biervliet
authors.forename: M
authors.initials: M
authors.lastname: Van Winckel
authors.forename: E
authors.initials: E
authors.lastname: Robberecht
authors.forename: I
authors.initials: I
authors.lastname: Kerremans
mesh_terms: D013505:Digestive System Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D004933:Esophageal Atresia / Q000175:diagnosis / Q000601:surgery*; D004940:Esophageal Stenosis / Q000188:drug therapy* / Q000209:etiology; D004941:Esophagitis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome
chemical_list: D004791:Enzyme Inhibitors; D009853:Omeprazole