title: Regional low-flow perfusion provides somatic circulatory support during neonatal aortic arch surgery.
abstract: BACKGROUND
  Regional low-flow perfusion has been shown to provide cerebral circulatory support during neonatal aortic arch operations. However, its ability to provide somatic circulatory support remains unknown.
  
  
  METHODS
  Fifteen neonates undergoing arch reconstruction with regional perfusion were studied. Three techniques were used to assess somatic perfusion: abdominal aortic blood pressure, quadriceps blood flow (near-infrared spectroscopy), and gastric tonometry.
  
  
  RESULTS
  Twelve patients required operation for hypoplastic left heart syndrome, and 3 required arch reconstruction with a biventricular repair. There was one death (7%). Abdominal aortic blood pressure was higher (12+/-3 mm Hg versus 0+/-0 mm Hg), and quadriceps blood volumes (5+/-24 versus -17+/-26) and oxygen saturations (57+/-25 versus 33+/-12) were greater during regional perfusion than during deep hypothermic circulatory arrest (p < 0.05). During rewarming, the arterial-gastric mucosal carbon dioxide tension difference was lower after circulatory arrest than after regional perfusion (-3.3+/-0.3 mm Hg versus 7.8+/-7.6 mm Hg, p < 0.05).
  
  
  CONCLUSIONS
  Regional low-flow perfusion provides somatic circulatory support during neonatal arch surgical procedures. Support of the subdiaphragmatic viscera should improve the ability of neonates to survive the postoperative period.
authors.affiliation: Division of Pediatric Cardiothoracic Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA. pigulaf@heart.chp.edu
authors.forename: F A
authors.initials: FA
authors.lastname: Pigula
authors.forename: S K
authors.initials: SK
authors.lastname: Gandhi
authors.forename: R D
authors.initials: RD
authors.lastname: Siewers
authors.forename: P J
authors.initials: PJ
authors.lastname: Davis
authors.forename: S A
authors.initials: SA
authors.lastname: Webber
authors.forename: E M
authors.initials: EM
authors.lastname: Nemoto
mesh_terms: D001012:Aorta, Abdominal; D001013:Aorta, Thoracic / Q000601:surgery*; D001017:Aortic Coarctation / Q000601:surgery*; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000098:blood supply; D002315:Cardiopulmonary Bypass / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000601:surgery; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000601:surgery*; D007231:Infant, Newborn; D008297:Male; D016343:Monitoring, Intraoperative; D018482:Muscle, Skeletal / Q000098:blood supply*; D010477:Perfusion; D012039:Regional Blood Flow / Q000502:physiology; D013270:Stomach / Q000098:blood supply*