Pneumonitis induced by ou-gon (scullcap).
A 53-year-old Japanese man with recurrent interstitial pneumonia was referred to us. The patient had taken a traditional herb medicine, otsu-ji-to, before the onset of pneumonia. A provocation test for each herbal ingredient contained in otsu-ji-to revealed that the pneumonitis had been induced by ou-gon (scullcap). Lymphocytosis with the CD8+ T-cell subset predominance was found in the bronchoalveolar lavage fluid and lymphocytic alveolitis was noted in the transbronchial lung biopsy specimen after the provocation test. Ou-gon, or scullcap, should be included in the list of drugs with definite causal association with pneumonitis.
Takeshita
K
K
Department of Medicine, Keio University School of Medicine, Tokyo.
Saisho
Y
Y
Kitamura
K
K
Kaburagi
N
N
Funabiki
T
T
Inamura
T
T
Oyamada
Y
Y
Asano
K
K
Yamaguchi
K
K
D001706:Biopsy; D018414:CD8-Positive T-Lymphocytes; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D020835:Medicine, Kampo; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D004365:Drugs, Chinese Herbal