title: [Cardiac rhythm disturbances and prolonged QT interval with halofantrine].
abstract: OBJECTIVE
  To determine the importance of prolonged QT interval and electrocardiographic changes in children treated with halofantrin for an acute malaria attack.
  
  
  RESULTS
  Out of 25 children treated with halofantrin, nine had an increase of QTc interval < 440 ms and ten a QTc > 440 ms on control 24 h after the first dose. A 9-year-old girl, treated with halofantrin, had bradycardia and increase of QTc interval for six days, with a normal halofantrin blood level.
  
  
  CONCLUSIONS
  These data show that cardiac monitoring during halofantrin treatment is mandatory in children as in adults. Contraindications of halofantrin treatment must be respected, particularly a long congenital QT interval.
authors.affiliation: Hôpital Saint-Vincent-de-Paul, 74-82, avenue Denfert-Rochereau, 75674 Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Lavallée
authors.forename: E
authors.initials: E
authors.lastname: Marc
authors.forename: F
authors.initials: F
authors.lastname: Moulin
authors.forename: J M
authors.initials: JM
authors.lastname: Treluyer
authors.forename: P
authors.initials: P
authors.lastname: Imbert
authors.forename: D
authors.initials: D
authors.lastname: Gendrel
mesh_terms: D000293:Adolescent; D000962:Antimalarials / Q000009:adverse effects* / Q000627:therapeutic use; D001919:Bradycardia / Q000139:chemically induced*; D002648:Child; D002675:Child, Preschool; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D008133:Long QT Syndrome / Q000139:chemically induced*; D008288:Malaria / Q000188:drug therapy; D008297:Male; D010616:Phenanthrenes / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D010616:Phenanthrenes; C023768:halofantrine
vernacular_title: Troubles du rythme et allongement de l'espace QT sous halofantrine.