title: Tl-201 chloride and Tc-99m MIBI accumulation in lung adenocarcinoma in patients with and without distant metastases.
abstract: OBJECTIVE
  The relation between Tl-201 chloride accumulation by the tumor and its distant metastatic potential were evaluated in patients with lung adenocarcinoma and compared with the same parameters achieved using Tc-99m MIBI.
  
  
  METHODS
  Fifty-six patients with primary lung adenocarcinoma were examined before therapy was begun. They were classified according to the radiologic findings and pathologic diagnosis into two groups: distant metastases and no distant metastases. All patients underwent dual-isotope imaging with Tl-201 chloride and Tc-99m MIBI. Regions of interest were placed over the tumor uptake (T) and contralateral normal lung tissue (N) areas on one transverse view with clearly defined lesions, and the T:N ratio and retention index were calculated.
  
  
  RESULTS
  The early and delayed T:N ratios and retention index using Tl-201 chloride SPECT in the distant-metastases group were significantly greater (P < 0.001 to P < 0.05) than were those in the no-distant-metastases group. There was no significant correlation between the T:N ratio and retention index and distant metastatic potential using Tc-99m MIBI SPECT.
  
  
  CONCLUSIONS
  Tl-201 chloride SPECT may be more effective than Tc-99m MIBI SPECT for evaluating the distant metastatic potential of primary lung adenocarcinoma.
authors.affiliation: Department of Radiology, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. yuka@kms.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: K
authors.initials: K
authors.lastname: Fukunaga
authors.forename: K
authors.initials: K
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Ohkawa
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D013793:Thallium; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; C027549:thallium chloride; D017256:Technetium Tc 99m Sestamibi; D013793:Thallium