Verbalactone, a new macrocyclic dimer lactone from the roots of Verbascum undulatum with antibacterial activity.
A novel macrocyclic dimer lactone, named verbalactone, was isolated from the roots of Verbascum undulatum and exhibited interesting antibacterial activity. It is the first time that 1,7-dioxacyclododecane is reported as the ring system of a natural product. The structure and the absolute stereochemistry of the new compound were determined by spectral methods and chemical correlation.
Magiatis
P
P
Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens Panepistimiopolis Zografou, GR-15771 Athens, Greece.
Spanakis
D
D
Mitaku
S
S
Tsitsa
E
E
Mentis
A
A
Harvala
C
C
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003652:Decanoic Acids / Q000737:chemistry / Q000494:pharmacology; D021902:Enterobacter aerogenes / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006115:Greece; D007711:Klebsiella pneumoniae / Q000187:drug effects; D007780:Lacticaseibacillus casei / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012477:Salmonella enteritidis / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013237:Stereoisomerism
C436564:3,5-dihydroxydecanoic acid; D000900:Anti-Bacterial Agents; D003652:Decanoic Acids; D007783:Lactones; C436563:verbalactone