Does GnRH analog improve the final height in Thai girls with idiopathic central precocious puberty?
Ten Thai girls with idiopathic central precocious puberty (ICPP) were treated with gonadotrophin releasing hormone (GnRH) analog for a mean period of 1.5+/-0.4 years. The predicted adult height at the end of treatment was significantly higher than that at the start of treatment (158.2+/-7.9 vs 153.0+/-8.7 cm, p=0.009). In addition, treatment with GnRH analog could significantly regress the breast staging from 3.4+/-0.8 to 2.6+/-1.0 (p=0.04),but not the pubic hair staging. Five of them reached a final height which was not significantly higher than the predicted adult height before treatment (153.1+/-4.8 vs 150.7+/-1.0 cm, p=0.5). In conclusion, treatment with GnRH analog in Thai girls with ICPP can improve the predicted adult height and regress the breast staging. However, the improvement of final height is not promising.
Wacharasindhu
S
S
Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Srivuthana
S
S
Aroonparkmongkol
S
S
Trinavarat
P
P
D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001827:Body Height / Q000187:drug effects*; D015992:Body Mass Index; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D006801:Humans; D011237:Predictive Value of Tests; D011336:Probability; D011629:Puberty, Precocious / Q000175:diagnosis / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
C436203:relisorm L; D007987:Gonadotropin-Releasing Hormone