Treatment with sheng-mai-san reduces myocardial infarct size through activation of protein kinase C and opening of mitochondrial KATP channel.
Sheng-mei-san (SMS), a traditional Chinese formulation comprising Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae, has long been used for more than 700 years for patients with coronary heart disease. We attempted to clarify 1) whether SMS reduces myocardial infarct size, and 2) whether the infarct size-reducing effect of SMS is related to activation of protein kinase C and the opening of the mitochondrial KATP channels in Japanese white rabbits without collateral circulation. The results indicate that three days treatment but not acute treatment with SMS reduces myocardial infarct size through activation of protein kinase C and opening of the mitochondrial KATP channels.
Wang
N
N
Second Department of Internal Medicine, Gifu University School of Medicine, Japan.
Minatoguchi
S
S
Uno
Y
Y
Arai
M
M
Hashimoto
K
K
Hashimoto
Y
Y
Yamaguchi
K
K
Fukuda
K
K
Akao
S
S
Fujiwara
H
H
D000704:Analysis of Variance; D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D008565:Membrane Proteins / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D015221:Potassium Channels; D011493:Protein Kinase C / Q000378:metabolism*; D011817:Rabbits
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008565:Membrane Proteins; D015221:Potassium Channels; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination; C117780:mitochondrial K(ATP) channel; D011493:Protein Kinase C