Pattern of inheritance in three sudden unexplained death syndrome ("Lai-tai") families.
Sudden Unexplained Death Syndrome (SUDS) (or Lai-tai) is sudden death in previously healthy young adults without any structural cause of death from autopsy findings. Our previous data showed that familial SUDS is not X-linked recessive. The objective of this study was to determine the pattern of inheritance in familial SUDS using the ECG markers of Brugada syndrome (RBBB and ST-segment elevation in V1 to V3), SUDS and presumptive SUDS as phenotypes. We employed the standard 12-lead ECG and higher intercostal space (ICS) V1 to V3 (-V1 to -V3 and -2V1 to -2V3) leads ECG in SUDS relatives after procainamide and drew the pedigree. We studied 62 relatives of 9 SUDS victims who died in Singapore and selected 3 families (n = 34) for the procainamide test and ECG. The mean age was 36.4 +/- 23.6 years (4-78 years). Three SUDS families showed the same pattern of inheritance of autosomal dominant.
Sangwatanaroj
S
S
Department of Medicine, Faculty of Medicine, Chulalongkom University, Bangkok, Thailand.
Ngamchareon
C
C
Prechawat
S
S
D001344:Autopsy; D002423:Cause of Death; D003645:Death, Sudden / Q000208:ethnology*; D016757:Death, Sudden, Cardiac / Q000208:ethnology; D004562:Electrocardiography; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D010375:Pedigree; D012042:Registries; D018570:Risk Assessment; D013785:Thailand / Q000453:epidemiology