title: REST acts through multiple deacetylase complexes.
abstract: The RE1 binding silencer protein REST represses neuronal-specific gene expression in nonneuronal cell types. In this issue of Neuron, Ballas et al. show that REST inhibits gene expression via the recruitment of multiple histone deacetylase complexes.
authors.affiliation: Division of Neuroscience, Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: E C
authors.initials: EC
authors.lastname: Griffith
authors.forename: C W
authors.initials: CW
authors.lastname: Cowan
authors.forename: M E
authors.initials: ME
authors.lastname: Greenberg
mesh_terms: D000581:Amidohydrolases / Q000378:metabolism*; D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D020868:Gene Silencing; D009474:Neurons / Q000502:physiology*; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000378:metabolism*; D013116:Spinal Cord / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D016335:Zinc Fingers; D000099229:RE1-Silencing Transcription Factor
chemical_list: D000581:Amidohydrolases; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D000099229:RE1-Silencing Transcription Factor