title: [Clinical and immunological characteristics and specific features of the treatment of patients with recurrent sarcoidosis of respiratory organs].
abstract: In the past 35 years, the authors have followed up 5600 patients with sarcoidosis of respiratory organs (SRO), among whom 1.2 and 10.7% were found to have single and multiple recurrences. The clinical manifestations of recurrent sarcoidosis were moderate, by showing a drastic reduction in the count of T and T"a" lymphocytes, as well as helper lymphocytes, and an increase of circulating immune complexes and immunoglobulins G, A, and M. Poor adaptive responses (AR) defined by the blood leukocyte and lymphocyte counts that reflect the body's nonspecific responsiveness were concurrently diagnosed. In chronic recurrent SRO, poor AR as stress and superactivation amount to as much as 86.1%. To optimize treatment, the patients were given adaptogens (thymaline, levamisole, dibasole, etc.) that make AR better, by enhancing the efficiency of treatment, reducing its duration, and improving prognosis.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Kostina
authors.forename: N A
authors.initials: NA
authors.lastname: Brazhenko
authors.forename: E V
authors.initials: EV
authors.lastname: Gerasimova
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Alekseev
authors.forename: O V
authors.initials: OV
authors.lastname: Kol'nikova
authors.forename: N M
authors.initials: NM
authors.lastname: Balashova
authors.forename: R N
authors.initials: RN
authors.lastname: Nasorina
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000936:Antigen-Antibody Complex; D001562:Benzimidazoles / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007978:Levamisole / Q000627:therapeutic use; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013902:Radiography, Thoracic; D012008:Recurrence; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D013951:Thymus Hormones / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex; D001562:Benzimidazoles; D007136:Immunoglobulins; D013951:Thymus Hormones; C004453:bendazole; D007978:Levamisole; C032805:thymalin
vernacular_title: Kliniko-immunologicheskaia kharakteristika i osobennosti lecheniia bol'nykh s retsidiviruiushchimi formami sarkoidoza organov dykhaniia.