Origin of antiphospholipid antibodies.
Our observations and those from others give further support to our hypothesis that "autoimmune aPL" may be generated by immunization with products from bacteria or viruses after incidental exposure or infection. We also were able to generate an APS-like syndrome in a strain of mice susceptible to autoimmunity, indicating that other factors such as genetic factors are likely to be involved in development of APS. Furthermore, not all aPL generated by immunization with bacterial or viral products were pathogenic. Based on the clinical experience and on the numerous reports indicating the presence of aPL in large number of infectious diseases, it may be expected that not all aPL produced during infection are pathogenic. We hypothesize that a limited number aPL induced by certain viral or bacterial products would be pathogenic in certain groups of predisposed individuals. Identification of those bacterial or viral agents may help to find strategies for the prevention of production of "pathogenic" aPL. Alternatively, free peptides may be used to induce tolerance against aPL production.
Gharavi
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Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA. aghara@pol.net
Pierangeli
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SS
Harris
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EN
D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000032:analysis / Q000276:immunology*; D000917:Antibody Formation; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000276:immunology; D001419:Bacteria; D004195:Disease Models, Animal; D006801:Humans; D007114:Immunization; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology; D010455:Peptides; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology*; D011817:Rabbits; D013587:Syphilis / Q000175:diagnosis / Q000276:immunology; D014780:Viruses
D017152:Antibodies, Antiphospholipid; D010455:Peptides; D019038:Platelet Glycoprotein GPIb-IX Complex