title: [Activity of lacrimal plasmin-like enzymes in the evaluation of the corneal state after photorefraction surgery].
abstract: Forty-three patients (58 eyes) were observed, who used contact lenses for a long time before photorefraction operations (photorefraction keratectomy and laser specialized keratomileusis--PRK and LASIK). Measurements of lacrimal plasmin-like enzymes (PLE) were carried out before and after operations on a Uniscan II microreader. Corneal and conjunctival intactness was evaluated by Bengal rose staining. Before surgery PLE activity was 3.5 times higher than normally in the patients using contact lenses. After PRK and LASIK, PLE activity increased and was 25% lower after LASIK than after PRK. Based on the data of preoperative diagnosis (Bengal rose test, measurement of PLE activities, Norn and Schirmer tests), the patients with contact lens intolerance without hypoproduction of tears are recommended rehabilitation treatment with drugs activating the repair processes (Vitacic, etc.), while patients with contact lens intolerance and tear hypoproduction are recommended low concentrations of viscoelastic drugs (Vismed).
authors.forename: O A
authors.initials: OA
authors.lastname: Kashnikova
authors.forename: I A
authors.initials: IA
authors.lastname: Makarov
authors.forename: G S
authors.initials: GS
authors.lastname: Polunin
authors.forename: A N
authors.initials: AN
authors.lastname: Ovchinnikov
authors.forename: O N
authors.initials: ON
authors.lastname: Mitiagina
mesh_terms: D003261:Contact Lenses / Q000009:adverse effects; D003315:Cornea / Q000502:physiology*; D003316:Corneal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D019781:Corneal Topography; D004338:Drug Combinations; D004548:Elasticity; D006157:Guanosine Monophosphate / Q000627:therapeutic use; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D054018:Lasers, Excimer; D009216:Myopia / Q000601:surgery; D009705:Nucleosides / Q000627:therapeutic use; D018903:Photorefractive Keratectomy; D011183:Postoperative Complications; D012307:Risk Factors; D013666:Tears / Q000201:enzymology* / Q000378:metabolism; D014783:Viscosity
chemical_list: D004338:Drug Combinations; D009705:Nucleosides; C020546:vitacic; D006157:Guanosine Monophosphate
vernacular_title: Aktivnost' plazminopodobnykh fermentov slezy v otsenke sostoianiia rogovitsy posle fotorefraktsionnykh operatsiĭ.