Imidazolopyrazinones as potential antioxidants.
A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree-Fock instabilities have been examined.
Devillers
I
I
Unité de Chimie organique et médicinale, Université catholique de Louvain, Bâtiment Lavoisier, place L. Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.
Dive
G
G
De Tollenaere
C
C
Falmagne
B
B
de Wergifosse
B
B
Rees
J F
JF
Marchand-Brynaert
J
J
D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007093:Imidazoles; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011719:Pyrazines / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry; D017382:Reactive Oxygen Species; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D007093:Imidazoles; D011719:Pyrazines; D011720:Pyrazoles; D017382:Reactive Oxygen Species; D013481:Superoxides; C017144:coelenterazine