Localization of retrovirus in the central nervous system of a patient co-infected with HTLV-1 and HIV with HAM/TSP and HIV-associated dementia.
Persons co-infected with HTLV-1 and HIV are at increased risk for neurologic disease. These patients may develop HAM/TSP and/or HIV-associated dementia. In this study, we localized cells infected with retrovirus in the central nervous system (CNS) of a patient with both HAM/TSP and HIV-associated dementia. HTLV-1 was localized to astrocytes and HIV to macrophage/microglia. There was no co-infection of a single cell phenotype in this patient. These data suggest that mechanisms other than co-infection of the same CNS cell may play a role in the development of neurologic disease in patients dual infected with HTLV-1 and HIV.
Levin
M C
MC
Department of Neurology, University of Tennessee Health Sciences Center, Memphis 38163, USA.
Rosenblum
M K
MK
Fox
C H
CH
Jacobson
S
S
D015526:AIDS Dementia Complex / Q000150:complications / Q000473:pathology / Q000821:virology*; D000328:Adult; D001253:Astrocytes / Q000473:pathology / Q000821:virology; D001921:Brain / Q000473:pathology / Q000821:virology; D002490:Central Nervous System / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D016356:Gene Products, tax / Q000235:genetics; D006678:HIV / Q000235:genetics / Q000302:isolation & purification; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008264:Macrophages / Q000473:pathology / Q000821:virology; D008297:Male; D017628:Microglia / Q000473:pathology / Q000821:virology; D015493:Paraparesis, Tropical Spastic / Q000150:complications / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D012190:Retroviridae / Q000235:genetics / Q000302:isolation & purification*; D012514:Sarcoma, Kaposi / Q000150:complications / Q000175:diagnosis; D013116:Spinal Cord / Q000473:pathology / Q000821:virology
D004279:DNA, Viral; D016356:Gene Products, tax; D012367:RNA, Viral