title: HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families.
abstract: summary: We describe an extension to the Homologous Structure Alignment Database (HOMSTRAD; Mizuguchi et al., Protein Sci., 7, 2469-2471, 1998a) to include homologous sequences derived from the protein families database Pfam (Bateman et al., Nucleic Acids Res., 28, 263-266, 2000). HOMSTRAD is integrated with the server FUGUE (Shi et al., submitted, 2001) for recognition and alignment of homologues, benefitting from the combination of abundant sequence information and accurate structure-based alignments. AVAILABILITY The HOMSTRAD database is available at: http://www-cryst.bioc.cam.ac.uk/homstrad/. Query sequences can be submitted to the homology recognition/alignment server FUGUE at: http://www-cryst.bioc.cam.ac.uk/fugue/.
authors.affiliation: Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
authors.forename: P I
authors.initials: PI
authors.lastname: de Bakker
authors.forename: A
authors.initials: A
authors.lastname: Bateman
authors.forename: D F
authors.initials: DF
authors.lastname: Burke
authors.forename: R N
authors.initials: RN
authors.lastname: Miguel
authors.forename: K
authors.initials: K
authors.lastname: Mizuguchi
authors.forename: J
authors.initials: J
authors.lastname: Shi
authors.forename: H
authors.initials: H
authors.lastname: Shirai
authors.forename: T L
authors.initials: TL
authors.lastname: Blundell
mesh_terms: D019295:Computational Biology; D030562:Databases, Protein; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*; D016415:Sequence Alignment / Q000706:statistics & numerical data*
chemical_list: D011506:Proteins