Synthesis and antiproliferative activity of epoxy and bromo compounds derived from estrone.
Based on biological properties of epoxyquinols from natural sources, bromo and epoxyquinols derived from estrone were synthesized and screened against Fem-X, HeLa and K(562) cell lines. Evidence was found that the bromine atom and the epoxy moiety significantly increase the antiproliferative activity within the series.
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Faculty of Chemistry, University of Belgrade, Studentski trg 16, PO Box 158, YU-11001, Belgrade, Yugoslavia.
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D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001966:Bromine / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004852:Epoxy Compounds / Q000737:chemistry*; D004970:Estrone / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D004970:Estrone; D001966:Bromine