title: Arginine deficiency-induced hyperammonemia in a home total parenteral nutrition-dependent patient: a case report.
abstract: BACKGROUND
  Patients with short bowel syndrome and renal dysfunction with TPN dependence are at high risk for developing hyperammonemia if the TPN does not contain sufficient quantities of arginine. Providing proper nutrition support is essential in the management of these patients.
  
  
  METHODS
  We report on a patient with short bowel syndrome, TPN dependence, and normal renal function who developed hyperammonemic encephalopathy due to inadvertent lack of arginine in his TPN.
  
  
  RESULTS
  The patient was successfully treated with hemodialysis and an IV arginine infusion to resolve the hyperammonemia. His home TPN was also adjusted such that arginine was added to his subsequent solutions.
  
  
  CONCLUSIONS
  Our patient underscores the importance of adequate and sustained arginine supplementation to avoid hyperammonemia in TPN dependent patients with short bowel syndrome.
authors.affiliation: Department of Pharmacy, Grace Hospital, Detroit, Michigan, USA.
authors.forename: S
authors.initials: S
authors.lastname: Kapila
authors.forename: M
authors.initials: M
authors.lastname: Saba
authors.forename: C H
authors.initials: CH
authors.lastname: Lin
authors.forename: E V
authors.initials: EV
authors.lastname: Bawle
mesh_terms: D000328:Adult; D001120:Arginine / Q000008:administration & dosage / Q000172:deficiency*; D006801:Humans; D022124:Hyperammonemia / Q000209:etiology*; D008297:Male; D016562:Parenteral Nutrition, Home Total / Q000009:adverse effects*; D012778:Short Bowel Syndrome / Q000628:therapy*
chemical_list: D001120:Arginine