Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation.
Identification and characterization of protein-protein interactions between the host cell and parasites both enhance our understanding of basic cell biology and provide insights into central processes of parasite life cycles. Research on HIV-1 has broadened our knowledge of the various molecular events involved. However, our understanding of how this virus interacts with the host cell at the level of protein-protein interaction is still limited. Through these interactions the virus is able to recruit certain cellular metabolic pathways for its replication. Here we summarize our current knowledge of protein-protein interactions between HIV-1 and host cell factors during viral replication.
Tasara
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Institute of Veterinary Biochemistry, University of Zürich-Irchel, Zürich, Switzerland.
Hottiger
M O
MO
Hübscher
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U
D015967:Gene Expression Regulation, Viral; D023281:Genomics; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000737:chemistry / Q000235:genetics* / Q000254:growth & development; D006801:Humans; D014158:Transcription, Genetic / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics* / Q000502:physiology; D014779:Virus Replication / Q000235:genetics*
D014764:Viral Proteins