title: Pneumonectomy for non-small cell lung cancer: predictors of operative mortality and survival.
abstract: OBJECTIVE
  The purpose of this study was to identify predictors of operative mortality and survival following pneumonectomy for non-small cell lung cancer (NSCLC).
  
  
  METHODS
  All 206 patients having a pneumonectomy for NSCLC between 1991 and 1997 in our unit were prospectively studied. There were 162 males (79%) and 44 females (21%) with a mean age (+/- standard deviation) of 61+/-7.7 years (range 34-81 years). Squamous cell (75%) and adenocarcinoma (17.0%) were the predominant histological types. The possible impact of 29 parameters on operative mortality and survival was tested with univariate and multivariate analysis. The mean follow-up was 2.3+/-1.2 years, ranging between 0 and 6.8 years, and it was complete.
  
  
  RESULTS
  Operative mortality was 6.8% (14 deaths). On multiple logistic regression older age (P=0.04) and the development post-operatively of bronchopleural fistula (BPF) (P=0.01) were independent predictors of operative mortality. The overall, Kaplan-Meier, 1-, 3- and 5-year survival (+/- standard error from the mean), inclusive of operative mortality, was 68+/-3.3, 42+/-4.1 and 35+/-4.5%. On Cox proportional hazards regression adenocarcinoma (P=0.006), the development of BPF (P=0.003), older age (P=0.03) and higher pathological stage (P=0.02) were independent adverse predictors of survival.
  
  
  CONCLUSIONS
  Pneumonectomy for NSCLC carries a considerable, but acceptable, operative mortality and provides an important survival benefit. This study suggests that older age and BPF are major determinants of an unfavourable in-hospital outcome; older age, BPF, adenocarcinoma cell type and higher pathological stage significantly reduce the probability of a long-term survival.
authors.affiliation: Department of Cardiothoracic Surgery, City Hospital, NG5 1PB, Nottingham, UK.
authors.forename: C
authors.initials: C
authors.lastname: Alexiou
authors.forename: D
authors.initials: D
authors.lastname: Beggs
authors.forename: M L
authors.initials: ML
authors.lastname: Rogers
authors.forename: L
authors.initials: L
authors.lastname: Beggs
authors.forename: S
authors.initials: S
authors.lastname: Asopa
authors.forename: F D
authors.initials: FD
authors.lastname: Salama
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000401:mortality; D011183:Postoperative Complications; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016156:Respiratory Tract Fistula / Q000209:etiology; D015996:Survival Rate