Use of montelukast as steroid-sparing agent for recurrent eosinophilic gastroenteritis.
Patients with eosinophilic gastroenteritis generally respond well to corticosteroids but relapses are common. Patients with relapsing disease are usually placed on long-term low-dose prednisone or immunosuppressive therapy. Here we reported on a patient with severe steroid-dependent eosinophilic gastroenteritis who was able to successfully taper off steroids and maintain remission after starting montelukast, a leukotriene receptor antagonist. To our knowledge, this is the first use of montelukast as a steroid sparing agent for eosinophilic gastroenteritis.
Schwartz
D A
DA
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA. Schwartz.David@Mayo.edu
Pardi
D S
DS
Murray
J A
JA
D000085:Acetates / Q000627:therapeutic use*; D000328:Adult; D003521:Cyclopropanes; D004802:Eosinophilia / Q000188:drug therapy*; D005759:Gastroenteritis / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D011804:Quinolines / Q000627:therapeutic use*; D012008:Recurrence; D013440:Sulfides
D000085:Acetates; D003521:Cyclopropanes; D005938:Glucocorticoids; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast; D011241:Prednisone