title: Evaluation of the antidiabetic action of Mangifera indica in mice.
abstract: The leaves of Mangifera indica were assessed for antidiabetic properties using normoglycaemic, glucose-induced hyperglycaemia and streptozotocin (STZ) induced diabetic mice. The aqueous extract produced a reduction of blood glucose level in normoglycaemic and glucose-induced hyperglycaemia, but did not have any effect on streptozotocin-induced diabetic mice. The hypoglycaemic effect of the aqueous extract was compared with that of an oral dose of chlorpropamide under the same conditions. The results of this study indicate that the aqueous extract of the leaves of Mangifera indica possess hypoglycaemic activity.
authors.affiliation: Department of Pharmacology and Therapeutics, Faculty of Health Sciences, University of Ilorin, Nigeria.
authors.forename: A O
authors.initials: AO
authors.lastname: Aderibigbe
authors.forename: T S
authors.initials: TS
authors.lastname: Emudianughe
authors.forename: B A
authors.initials: BA
authors.lastname: Lawal
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005947:Glucose; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D010946:Plants, Medicinal; D019685:Rosales; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin; D005947:Glucose