Synthesis of six novel N,N-dialkyl derivatives of spermidine and effects on growth of the fungal plant pathogen Pyrenophora avenae.
Six novel N,N-dialkyl derivatives of spermidine were synthesised and examined for activity against the oat stripe pathogen Pyrenophora avenae. Two of these spermidine analogues, N,N-dimethyl-N1-(3-aminopropyl)-1,3-diaminopropane trihydrochloride (27) and N,N-dimethyl-N1-(3-aminopropyl)-1,4-diaminobutane trihydrochloride (28), reduced radial extension of P. avenae on plates when used at 2 mM, and caused more substantial reductions in fungal growth in liquid culture when used at 1 mM. Preliminary data suggest that neither compound affected polyamine biosynthesis, determined by following the incorporation of label from ornithine into polyamines and examining intracellular polyamine concentrations in fungal tissue.
Mackintosh
C A
CA
Plant Biology Department, Scottish Agricultural College, Auchincruive, Ayr KA6 5HW, UK.
Slater
L A
LA
Walters
D R
DR
Robins
D J
DJ
D018554:Avena / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D005659:Fungicides, Industrial / Q000494:pharmacology*; D013095:Spermidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D005659:Fungicides, Industrial; D013095:Spermidine