[Diagnostic significance of the cerebrospinal fluid protein spectrum in bacterial and viral meningitis in children].
Protein spectrum of the cerebrospinal fluid (CSF) was studied by polyacrylamide gel disk electrophoresis in 119 children with bacterial and 17 with viral meningitis of different origin over the course of disease. Liquor proteinograms of patients were compared with those of 37 children without meningitis. Protein spectra of the CSF were shifted in the patients. These shifts can serve as differential diagnostic markers: types 1-2 and 2-2 haptoglobins and beta-lipoprotein appears in the blood during the acute period of disease. More pronounced and stubborn changes in the CSF protein spectrum in pneumococcal and hemophilic meningitis correlated with a more severe clinical course and formation of residual neurological consequences. Progress of dysproteinemic shifts in the protein spectrum of the CSF was characterized by a many-fold increase in the concentrations of high-molecular-weight proteins and decreased relative content of liquor-specific fractions, indicating sharp impairment of the blood-brain barrier permeability and formation of brain edema. Disk electrophoresis method is characterized by high resolution, informative value, requires low amounts of CSF for analysis, and is recommended as an accessory diagnostic test for infectious hospitals.
Alekseeva
L A
LA
Sorokina
M N
MN
D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D002648:Child; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid*; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid*
D002556:Cerebrospinal Fluid Proteins
Diagnosticheskoe znachenie belkovogo spektra tserebrospinal'noĭ zhidkosti pri bakterial'nykh i virusnykh meningitakh u deteĭ.