title: Diverse cyclization catalyzed by In(OTf)3 for the convergent assembly of substituted tetrahydrofurans and tetrahydropyrans.
abstract: [reaction: see text]. A novel In(OTf)3-catalyzed (3,5) oxonium-ene type cyclization for the facile construction of various multisubstituted tetrahydrofurans and tetrahydropyrans was successfully developed. Further mechanistic investigations unveiled an In(OTf)3-catalyzed skeletal reorganization of the tetrahydrofuran to its thermodynamic isomer under thermal conditions.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543. chmlphtp@nus.edu.sg
authors.forename: T P
authors.initials: TP
authors.lastname: Loh
authors.forename: Q Y
authors.initials: QY
authors.lastname: Hu
authors.forename: K T
authors.initials: KT
authors.lastname: Tan
authors.forename: H S
authors.initials: HS
authors.lastname: Cheng