Successful therapy of pure red cell aplasia secondary to plasma cell dyscrasia with bolus methylprednisolone.
A 65-year-old man, who is a Jehovah's Witness, was admitted to our hospital due to progressive anemia following a four-year history of biclonal gammopathy of no clinical significance. He was diagnosed with pure red cell aplasia (PRCA) associated with plasma cell dyscrasia. Despite a markedly decreased red blood cell count (hematocrit 5.6%), the patient refused transfusion. He was intravenously administered bolus methylprednisolone. Reticulocytosis and recovery from anemia were observed on day 7 after the start of therapy. Secondary PRCA following plasma cell dyscrasia is a rare disorder; the treatments for this rare condition are discussed.
Matsuhashi
Y
Y
Department of Medicine, Kagawa Prefectural Central Hospital, Takamatsu.
Tasaka
T
T
Uehara
E
E
Kamei
T
T
Tamura
T
T
Nagai
M
M
D000368:Aged; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D010265:Paraproteinemias / Q000150:complications*; D012010:Red-Cell Aplasia, Pure / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D016896:Treatment Outcome
D005938:Glucocorticoids; D008775:Methylprednisolone