title: Dioxins in adipose tissue of non-occupationally exposed persons in France: correlation with individual food exposure.
abstract: We evaluated individual adipose tissue (subcutaneous lipomas) dioxin contamination in non-occupationally exposed persons living in France (adult patients undergoing a surgical ablation of benign lipomas), in relation to the corresponding individually evaluated mean daily dietary dioxin intake (DDDI). The diet survey (questionnaire) included information on consumption of meat, fish, milk and dairy products, from which the individual DDDI was calculated. Sixteen subjects participated in this study. DDDI ranged between 1.06 and 3.31 pg I-TEQ/kg body weight, bw (mean value: 2.05+/-0.72). Adipose tissue polychlorinated dibenzo-p-dioxins (PCDD)/polychlorinated dibenzofurans (PCDF) levels ranged between 18.5 and 76.9 pg I-TEQ/g lipids (mean value: 35.6+/-14.8). No relation was found between the DDDI and adipose tissue PCDD/PCDF concentrations. The mean DDDI in France does not fundamentally differ from those found in other industrialised countries, is within the range of 1-4 pg I-TEQ/kg/day recently suggested by WHO-ECEH/ICPS for the tolerable daily intake of dioxins. Adipose tissue PCDD/PCDFs levels are similar to levels in other European countries and USA without relation to sex or age, and can be considered representative European background concentrations. Globalisation of alimentary production leads to a similar food exposure in Western European countries, in spite of dioxins accidental selective contaminations that are epiphenomenon and thus do not have any impact in human dioxin background levels.
authors.affiliation: Laboratoire d'Hygiene el de Santé Publique, UFR des Sciences Pharmaceutiques et Biologiques, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Arfi
authors.forename: N
authors.initials: N
authors.lastname: Seta
authors.forename: D
authors.initials: D
authors.lastname: Fraisse
authors.forename: A
authors.initials: A
authors.lastname: Revel
authors.forename: J P
authors.initials: JP
authors.lastname: Escande
authors.forename: I
authors.initials: I
authors.lastname: Momas
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000368:Aged; D001572:Benzofurans / Q000032:analysis / Q000493:pharmacokinetics*; D000072338:Dibenzofurans, Polychlorinated; D004032:Diet; D004781:Environmental Exposure; D005260:Female; D005506:Food Contamination; D005602:France; D006801:Humans; D008067:Lipoma / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics*; D012989:Soil Pollutants / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants