HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum.
Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase with IC50 values of 7.8 +/- 3.6 and 13.7 +/- 6.0 microM, respectively.
Kim
H J
HJ
Division of Life Sciences, Korea Institute of Science & Technology, Seoul.
Woo
E R
ER
Shin
C G
CG
Hwang
D J
DJ
Park
H
H
Lee
Y S
YS
D004187:Disaccharides / Q000494:pharmacology*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D019428:HIV Integrase Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000201:enzymology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009841:Oligonucleotides / Q000494:pharmacology; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D004187:Disaccharides; D019428:HIV Integrase Inhibitors; D009841:Oligonucleotides; D010936:Plant Extracts; D006139:Guaiacol