title: The effect of prophylactic metaraminol on systemic hypotension caused by induction of anaesthesia with propofol in patients over 55 years old.
abstract: We conducted a double-blind, randomised, placebo-controlled study evaluating the efficacy of prophylactic metaraminol for preventing propofol-induced hypotension. Thirty patients aged 55-75 years undergoing general anaesthesia were randomly allocated to receive either metaraminol 0.5 mg or saline before administration of fentanyl 1 microg.kg(-1) and propofol 2 mg.kg(-1). Induction of anaesthesia was associated with a decrease in mean and systolic arterial pressure in both groups (p = 0.0001). However, there was no significant difference between the two groups. These results show that prophylactic use of metaraminol 0.5 mg does not prevent the decrease in blood pressure following fentanyl and propofol induction in older patients.
authors.affiliation: Department of Anaesthesia, Faculty of Medicine, University of Malaya, 59100 Kuala Lumpur, Malaysia. chiucl@medicine.med.um.edu.my
authors.forename: C L
authors.initials: CL
authors.lastname: Chiu
authors.forename: G P
authors.initials: GP
authors.lastname: Tew
authors.forename: C Y
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000368:Aged; D000768:Anesthesia, General / Q000379:methods; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008680:Metaraminol / Q000627:therapeutic use*; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
chemical_list: D000316:Adrenergic alpha-Agonists; D018686:Anesthetics, Intravenous; D014662:Vasoconstrictor Agents; D008680:Metaraminol; D015742:Propofol