title: Synthesis of a new insoluble polymer-supported chiral alcohol auxiliary and its first application to nucleophilic addition to ketenes.
abstract: The preparation of a new optically active alcohol with a carboxylic function that allowed its attachment to an amine-functionalized insoluble polymer is described. Its first use as a polymer supported chiral auxiliary is demonstrated by asymmetric transformation of two racemic aryl propionic acids via ketene formation (95-96% ee).
authors.affiliation: Laboratoire des Amino acides, Peptides et Protéines, UMR-CNRS 5810-Universités Montpellier I et II, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
authors.forename: R
authors.initials: R
authors.lastname: Akkari
authors.forename: M
authors.initials: M
authors.lastname: Calmes
authors.forename: N
authors.initials: N
authors.lastname: Mai
authors.forename: M
authors.initials: M
authors.lastname: Rolland
authors.forename: J
authors.initials: J
authors.lastname: Martinez