title: Vaccination against gastrointestinal nematode parasites of ruminants using gut-expressed antigens.
abstract: To date, proteins isolated from the surface of the gut of gastrointestinal nematodes, particularly Haemonchus contortus, have generally proved to be useful protective antigens and several are being progressed towards recombinant protein-based vaccines. This paper describes the properties of some of the most promising antigens and summarises their performance in laboratory and field based trials. The antigens described include contortin, H11, H-gal-GP, GPI and cysteine proteinases. In addition, the discussion addresses the utility of selected antigens to protect against co-infecting nematode species such as Teladorsagia circumcincta and against related nematode infections such as Ostertagia ostertagi in cattle.
authors.affiliation: Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, Scotland EH26 0PZ, UK. knoxd@mri.sari.ac.uk
authors.forename: D P
authors.initials: DP
authors.lastname: Knox
authors.forename: W D
authors.initials: WD
authors.lastname: Smith
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D004064:Digestive System / Q000469:parasitology; D006188:Haemonchiasis / Q000517:prevention & control / Q000662:veterinary*; D006189:Haemonchus / Q000276:immunology*; D007411:Intestinal Diseases, Parasitic / Q000517:prevention & control / Q000662:veterinary*; D009348:Nematoda; D009349:Nematode Infections / Q000517:prevention & control / Q000662:veterinary; D012418:Ruminants / Q000469:parasitology*; D014611:Vaccination / Q000662:veterinary; D014612:Vaccines; D014614:Vaccines, Synthetic
chemical_list: D000947:Antigens, Helminth; D014612:Vaccines; D014614:Vaccines, Synthetic