Activation of mitochondrial glycerophosphate cytochrome c reductase in regenerating rat liver by triiodothyronine.
Triiodothyronine administration before partial hepatectomy increased the activity of mitochondrial glycerophosphate cytochrome c reductase. The enzyme activity was further activated after partial hepatectomy during the regenerative process. Our findings showed that: a) the increase of glycerophosphate cytochrome c reductase induced by triiodothyronine was further potentiated by the regeneration process, b) the high activity of the glycerophosphate shuttle was maintained after partial hepatectomy during the period, when most of the liver tissue had again been recovered.
Lotková
H
H
Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové Prague, Czech Republic.
Rauchová
H
H
Drahota
Z
Z
D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005994:Glycerophosphates / Q000378:metabolism; D006498:Hepatectomy; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D009245:NADH Dehydrogenase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014284:Triiodothyronine / Q000494:pharmacology*
D005994:Glycerophosphates; D014284:Triiodothyronine; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV