title: Changes with age in the Golgi apparatus of rabbit spinal ganglion neurons.
abstract: We studied the Golgi apparatus in spinal ganglion neurons of rabbits aged 12, 42 and 79 months. We found no structural changes, no indications of fragmentation, no indications of peripheral displacement affecting this organelle with advancing age. The volume of the perikaryon increased significantly with age, whereas the total volume of the Golgi apparatus remained essentially constant. Hence the mean percentage of perikaryal volume occupied by the Golgi apparatus decreased with age. This decrease was only in very minor part a consequence of lipofuscin accumulation, so that the ratio between the total volume of the Golgi apparatus and the functionally active volume of cytoplasm decreased with age. This decrease could be related to the reduced neuronal metabolism that occurs during ageing. It is possible that the delivery to the axon of newly synthesized proteins destined for fast transport is one of the Golgi apparatus roles that decrease with age. Finally, we found that the age-related quantitative changes in the Golgi apparatus did not differ between large light and small dark neurons.
authors.affiliation: Institute of Histology, Embryology and Neurocytology, University of Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ledda
authors.forename: L
authors.initials: L
authors.lastname: Barni
authors.forename: L
authors.initials: L
authors.lastname: Altieri
authors.forename: E
authors.initials: E
authors.lastname: Pannese
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D005260:Female; D005727:Ganglia, Spinal / Q000648:ultrastructure*; D006056:Golgi Apparatus / Q000648:ultrastructure*; D008297:Male; D009474:Neurons / Q000648:ultrastructure*; D011817:Rabbits