title: Evidence-based prevention of catheter infection during parenteral nutrition.
abstract: Parenteral nutrition is a risk factor for catheter-related bloodstream infection. Here we reviewed strategies for the prevention of catheter-related infections, which always must begin with the cornerstone of prevention: the strict adherence to aseptic techniques. Most research has been interested in coated catheters. From these results, it may be concluded that antibiotics or antiseptic-impregnated catheters, like those with minocycline-rifampicin or chlorhexidine/silver sulfadiazine, significantly reduce catheter-related blood stream infections. Antibiotics or antiseptic-impregnated central venous catheters may even result in cost saving in intensive care units. Antiseptic or antibiotic-lock techniques would also be of interest to prevent catheter-related sepsis in high-risk patients who are receiving parenteral nutrition.
authors.affiliation: Hepato-Gastroenterology Department and Nutritional Support Unit, Approved Centre for HPN in adults for the Ile de France region, Lariboisière Hospital, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Attar
authors.forename: B
authors.initials: B
authors.lastname: Messing
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002404:Catheterization / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods*; D004866:Equipment Contamination; D006801:Humans; D017063:Outcome Assessment, Health Care; D010288:Parenteral Nutrition / Q000009:adverse effects; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000891:Anti-Infective Agents, Local