Synthesis of (+)-galiellalactone. Absolute configuration of galiellalactone.
[reaction: see text]. (+)-Galiellalactone was synthesized starting from (R)-(+)-pulegone. Natural and synthetic galiellalactone have opposite optical rotations, demonstrating that the structure of the natural product is 1a.
Johansson
M
M
Department of Organic and Bioorganic Chemistry, Lund University, POB 124, S-221 00 Lund, Sweden.
Sterner
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O
D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008968:Molecular Conformation; D015398:Signal Transduction / Q000187:drug effects; D014407:Tumor Cells, Cultured; D000093242:Interleukin-6 Inhibitors
D007783:Lactones; D000093242:Interleukin-6 Inhibitors; C416043:galiellalactone