Lymphocyte development from hematopoietic stem cells.
The recent application of new techniques, such as multi-color cell sorting and the production of transgenic and gene-knockout mice, has contributed to a better understanding of lymphocyte development from hematopoietic stem cells. Now that we can purify progenitors at different maturational stages during lymphocyte development, the challenge is to understand the processes that govern each developmental stage transition.
Kondo
M
M
Department of Pathology, Stanford University School of Medicine, B259 Beckman Center, Stanford, CA 94305, USA. motonari.kondo@stanford.edu
Scherer
D C
DC
King
A G
AG
Manz
M G
MG
Weissman
I L
IL
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D003713:Dendritic Cells / Q000166:cytology; D015321:Gene Rearrangement / Q000235:genetics; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology; D008214:Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D011946:Receptors, Antigen / Q000235:genetics; D018121:Receptors, Cytokine / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D011946:Receptors, Antigen; D018121:Receptors, Cytokine; D014157:Transcription Factors