Diabetic patients on peritoneal dialysis need less erythropoietin to maintain adequate hemoglobin.
Peritoneal dialysis (PD) patients have been shown to require less erythropoietin as compared with hemodialysis (HD) patients to maintain similar hemoglobin values. In our unit, we observed that diabetic PD patients required less erythropoietin treatment than did other PD patients. We therefore compared the amount of erythropoietin needed in diabetic and non diabetic patients on PD to maintain a similar hemoglobin value. All polycystic patients were excluded from the study because they rarely require erythropoietin. We also excluded patients with bone marrow disease, active gastrointestinal bleeding, or patients very resistant (requiring more than 25,000 U per week) to Eprex (recombinant human erythropoietin: Janssen-Cilag, North York, Ontario, Canada). Patients not requiring Eprex were also excluded from the study. We calculated the weekly erythropoietin dose in the two groups. We also compared hemoglobin level, iron transferrin saturation, vitamin?12 level, and serum folate. Diabetic patients required a lower weekly erythropoietin dose. Diabetic PD patients in our unti receive an average 4497 U per week compared with 7593 U per week for non diabetic PD patients. The difference (approximately 3000 U per week) is statistically significant.
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Division of Nephrology, University of Ottawa and Ottawa Hospital, Ottawa, Ontario, Canada.
Cheung
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Poirier
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D003920:Diabetes Mellitus / Q000097:blood*; D003928:Diabetic Nephropathies / Q000628:therapy; D004921:Erythropoietin / Q000627:therapeutic use*; D005492:Folic Acid / Q000097:blood; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D014168:Transferrin / Q000032:analysis; D014805:Vitamin B 12 / Q000097:blood
D006454:Hemoglobins; D014168:Transferrin; D004921:Erythropoietin; D005492:Folic Acid; D014805:Vitamin B 12