title: Brain involvement in haemolytic-uraemic syndrome: MRI features of coagulative necrosis.
abstract: We describe radiological demonstration of brain involvement in haemolytic-uraemic syndrome (HUS) in two siblings with a very different clinical course. While the brother presented with a mild, reversible encephalopathy, his sister developed high-signal lesions in the cortex, putamen and caudate nucleus on T1-weighted images, seen as dense areas on CT. Biopsy revealed coagulative necrosis due to microthrombosis without haemorrhage, calcification or infection. These findings suggest a possible prognostic role for MRI in cases of encephalopathy due to HUS.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital-CHUV, Lausanne, Switzerland. sabschmidt67@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: F
authors.initials: F
authors.lastname: Gudinchet
authors.forename: K
authors.initials: K
authors.lastname: Meagher-Villemure
authors.forename: P
authors.initials: P
authors.lastname: Maeder
mesh_terms: D001778:Blood Coagulation Disorders / Q000473:pathology*; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007223:Infant; D020767:Intracranial Thrombosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D011859:Radiography