title: [3 years experience with low dosage fractionated percutaneous teletherapy in subfoveal neovascularization. Clinical results].
abstract: OBJECTIVE
  The effect of low dose fractionated percutaneous teletherapy to visual acuity and the changes in subfoveolar neovascular membranes in age-related macular degeneration were investigated.
  
  
  METHODS
  126 eyes of 118 patients (age 55-89 years; mean 74 ys.) were treated. Best distal and near visual acuity was assessed prior to (= initial visual acuity [IVA]) and 3, 6, 12, 18, 24, 30 and 36 months after teletherapy. Fluorescein angiography was performed prior to and 6, 12, 24 and 36 months after radiation therapy. For analysis patients were divided into different groups by IVA and membrane size. Maximal duration of observation was 36 months. Teletherapy was done by a 9-MeV photon linear accelerator through a lateral port in half-beam technique with a single dose of 2 Gy up to a total dose of 20 Gy within 12 days.
  
  
  RESULTS
  No severe negative side effects have been observed. Eight patients reported of epiphora and four patients complained of transient sicca syndrome. Visual acuity decreased more than one line in the group IVA 0.05-0.2. The group IVA 0.3-0.5 remained unchanged for 1 year. We found a tendency for increased visual acuity in group IVA > or = 0.6 for 18 months. After that time both groups showed decreased visual acuity, but all these patients reported of reduced metamorphopsia and increased color and contrast perception.
  
  
  CONCLUSIONS
  There is an influence of low dose fractionated percutaneous teletherapy on visual acuity, subfoveal neovascular membranes and metamorphopsia. IVA and duration of anamnesis play an important role. There seems to be no persistent effect; possibly increased dosage will bring a benefit.
authors.affiliation: Universitätsaugenklinik Rostock. michael.schittkowski@med.uni-rostock.de
authors.forename: M
authors.initials: M
authors.lastname: Schittkowski
authors.forename: H
authors.initials: H
authors.lastname: Schneider
authors.forename: K
authors.initials: K
authors.lastname: Grüschow
authors.forename: P G
authors.initials: PG
authors.lastname: Ziegler
authors.forename: R
authors.initials: R
authors.lastname: Guthoff
authors.forename: R
authors.initials: R
authors.lastname: Fietkau
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000532:radiotherapy*; D003118:Color Perception / Q000528:radiation effects; D015350:Contrast Sensitivity / Q000528:radiation effects; D019583:Dose Fractionation, Radiation; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators; D011867:Radioisotope Teletherapy / Q000295:instrumentation; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D014792:Visual Acuity / Q000528:radiation effects
vernacular_title: 3 Jahre Erfahrung mit der niedrig dosierten fraktionierten perkutanen Teletherapie bei subfoveolären Neovaskularisationen. Klinische Ergebnisse.