Utility of boron clusters for drug design. Hansch-fujita hydrophobic parameters pi of dicarba-closo-dodecaboranyl groups.
The spherical boron clusters, dicarba-closo-dodecaboranes (carboranes) are new hydrophobic pharmacophores, which interact hydrophobically with receptors. We have experimentally measured the partition coefficients log P for carboranylphenols employing an HPLC method, and determined the Hansch-Fujita hydrophobic parameters pi of various carboranyl groups. The values (pi=2.69-4.44) vary depending on the position of substitution on the carborane cage and the isomeric form (o-, m-, p-carboranes). These values lie within the range of those of hydrocarbons.
Yamamoto
K
K
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Endo
Y
Y
D001896:Boron Compounds / Q000737:chemistry* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism
D001896:Boron Compounds; D018160:Receptors, Cytoplasmic and Nuclear