[Formation of transcription factors AP-1 during learning in Helix].
An increase in the DNA-binding activity for the AP-1-family factors was shown to occur after food aversion conditioning. Learning experiments in vitro enhanced the DNA-binding activity. Effects of simultaneous action of serotonine and calcium on activation of transcriptional AP-1 factors was suppressed by inhibitor of calcium/calmodulin-dependent protein-kinases KN62 as well as by inhibitor of MAP-kinases PD98059. The co-operative induction of transcriptional AP-1 family factors activation by serotonine-induced and calcium-dependent regulatory systems may be one of the mechanisms of aversive conditioning in the CNS of the land snail.
Grinkevich
L N
LN
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6.
Lisachev
P D
PD
Merkulova
T I
TI
D000818:Animals; D001362:Avoidance Learning; D002118:Calcium / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D003216:Conditioning, Operant; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D017952:Ganglia, Invertebrate / Q000378:metabolism*; D006372:Helix, Snails; D007858:Learning; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors; D011493:Protein Kinase C / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology; D018808:Transcription Factor AP-1 / Q000378:metabolism*
D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D018808:Transcription Factor AP-1; D012701:Serotonin; D011493:Protein Kinase C; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D020928:Mitogen-Activated Protein Kinases; D002118:Calcium
Formirovanie transkriptsionnykh faktorov AP-1 pri obuchenii Helix.