title: Effects of desflurane and sevoflurane on length-dependent regulation of myocardial function in coronary surgery patients.
abstract: BACKGROUND
  Desflurane and sevoflurane have negative inotropic effects. The current study investigated whether these effects resulted in an altered left ventricular response to increased cardiac load and affected length-dependent regulation of myocardial function. Length-dependent regulation of myocardial function refers to the ability of the heart to improve its performance when preload is increased.
  
  
  METHODS
  A high-fidelity pressure catheter was positioned in the left ventricle and left atrium in 20 coronary surgery patients with a preoperative ejection fraction greater than 40%. Studies were performed before the initiation of cardiopulmonary bypass. Left ventricular response to increased cardiac load, obtained by leg elevation, was assessed during control conditions and during increasing concentrations of desflurane (2, 4, and 6% end tidal; n = 10) or sevoflurane (1, 2, and 3% end tidal; n = 10). Effects on contraction were evaluated by analysis of changes in maximal rate of pressure development. Effects on relaxation were assessed by analysis of changes in minimum rate of pressure development and by analysis of the load dependence of myocardial relaxation (R = slope of the relation between time constant tau of isovolumic relaxation and end-systolic pressure). Peak left atrial-left ventricular pressure gradients were analyzed during early left ventricular filling.
  
  
  RESULTS
  With both desflurane and sevoflurane, maximal and minimum rates of pressure development decreased while tau increased. Peak left atrial-left ventricular pressure gradients remained unchanged. The hemodynamic effects of leg elevation were similar at the different concentrations. Changes in parameters of contraction and relaxation during leg elevation were coupled and were not altered by desflurane or sevoflurane.
  
  
  CONCLUSIONS
  Despite their negative inotropic and lusitropic effects, neither desflurane nor sevoflurane adversely affect length-dependent regulation of left ventricular function. In the conditions of our study, the ability of the left ventricular to respond to increased cardiac load is not altered by the use of desflurane or sevoflurane.
authors.affiliation: Department of Anesthesiology, University Hospital Antwerp, Edegem, Belgium. sdehert@uia.ac.be
authors.forename: S G
authors.initials: SG
authors.lastname: De Hert
authors.forename: P J
authors.initials: PJ
authors.lastname: Van der Linden
authors.forename: P W
authors.initials: PW
authors.lastname: ten Broecke
authors.forename: K T
authors.initials: KT
authors.lastname: Vermeylen
authors.forename: I E
authors.initials: IE
authors.lastname: Rodrigus
authors.forename: B A
authors.initials: BA
authors.lastname: Stockman
mesh_terms: D000368:Aged; D018685:Anesthetics, Inhalation; D016279:Atrial Function, Left / Q000187:drug effects / Q000502:physiology; D001026:Coronary Artery Bypass; D000077335:Desflurane; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives; D007866:Leg / Q000098:blood supply; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D000077149:Sevoflurane; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane