Bisoprolol vs. chlorthalidone: a randomized, double-blind, comparative study in arterial hypertension.
The antihypertensive effect and tolerance of bisoprolol and chlorthalidone were evaluated in a randomized, double-blind, controlled trial during 4 weeks of treatment. A total of46 patients, aged 18-65 years, were initially included; 41 patients presenting with a diastolic blood pressure between 95 and 120 mm Hg at the end of a previous placebo period completed the trial. They were randomly allocated to two groups: 22 patients were treated with bisoprolol 10 mg o.d., and 19 patients with chlorthalidone 50 mg o.d. Both treatments induced a significant reduction in systolic and diastolic blood pressure (p < 0.001). No difference in antihypertensive efficacy was found between the two treatments after 4 weeks. However, with chlorthalidone, significant changes were found with regard to serum potassium (decrease; p < 0.001) and uric acid (increase: p < 0.05) and the incidence of clinical side effects was higher in the chlorthalidone group (37%) in comparison to the patients treated with bisoprolol (13%).
Bueno
J
J
Internal Medicine Service, Hospital Clinico, Zaragoza, Spain.
Amiguet
J A
JA
Carasusan
J
J
Cebollada
J
J
Carretero
J
J
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017298:Bisoprolol / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D016009:Chi-Square Distribution; D002752:Chlorthalidone / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D016037:Single-Blind Method; D014527:Uric Acid / Q000097:blood
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D014527:Uric Acid; D002752:Chlorthalidone; D011188:Potassium; D017298:Bisoprolol