Cadherin function: breaking the barrier.
Three desmoglein isoforms collaborate with desmocollins to build the adhesive core of desmosomes. A recent study has shown that altering the ratio of desmoglein isoforms influences epidermal barrier function, suggesting distinct roles for these cadherins that extend beyond adhesion.
Ishii
K
K
Departments of Pathology and Dermatology, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois 60611, USA.
Green
K J
KJ
D000818:Animals; D015820:Cadherins / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology; D051187:Desmocollins; D051182:Desmogleins; D051180:Desmoplakins; D003896:Desmosomes / Q000502:physiology; D004817:Epidermis / Q000502:physiology; D006801:Humans; D020033:Protein Isoforms / Q000502:physiology
D015820:Cadherins; D003598:Cytoskeletal Proteins; D051187:Desmocollins; D051182:Desmogleins; D051180:Desmoplakins; D020033:Protein Isoforms