Development of a low-metal adhesive tape to detect and localize metals in or on the stratum corneum at parts per million levels.
Tape-stripping is a well-established method for sampling the stratum corneum (SC). We have developed a tape with low-metal content suitable for use with particle-induced X-ray emission (PIXE), an analytical technique based on X-ray spectrometry. PIXE analysis of tape-stripped samples of SC is a reliable and minimally invasive means of identifying and quantifying metals present at parts per million levels. Assay feasibility and reproducibility was demonstrated using human volunteers. This new tape-strip technique has potential applications in exposure and decontamination assessment, diagnosis of metal dermatitis, forensics, and in environmental research.
Cullander
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School of Pharmacy, University of California, San Francisco, CA 94143-0150, USA.
Grant
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PG
Bench
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D000269:Adhesives / Q000737:chemistry*; D006801:Humans; D008670:Metals / Q000737:chemistry*; D012867:Skin / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission
D000269:Adhesives; D008670:Metals