Campylobacter jejuni--microtubule-dependent invasion.
Campylobacter jejuni is the leading bacterial cause of food-borne illness worldwide and a major cause of Guillain-Barré paralysis. Recent molecular and cellular studies of one well-characterized C. jejuni strain have begun to unravel the details of an unusual microtubule-dependent (actin-filament-independent) gut-invasion mechanism, through which at least some C. jejuni initiate disease. Although responsible for causing a human dysenteric syndrome remarkably similar to that triggered by Shigella spp., current evidence suggests that C. jejuni use some markedly different molecular mechanisms of pathogenesis compared with shigellae.
Kopecko
D J
DJ
Laboratory of Enteric and Sexually Transmitted Diseases, FDA-Center for Biologics Evaluation and Research, Bldg 29/420, NIH Campus, Bethesda, MD 20892, USA. kopecko@cber.fda.gov
Hu
L
L
Zaal
K J
KJ
D002169:Campylobacter Infections / Q000382:microbiology*; D016123:Campylobacter jejuni / Q000235:genetics / Q000472:pathogenicity*; D004405:Dysentery, Bacillary / Q000382:microbiology; D004847:Epithelial Cells / Q000382:microbiology; D006801:Humans; D007422:Intestines / Q000166:cytology / Q000382:microbiology; D008870:Microtubules / Q000382:microbiology* / Q000502:physiology; D014774:Virulence