[Micronucleus frequency is increased in bone marrow erythrocytes from offspring of male mice exposed to chronic low-dose gamma irradiation].
The micronucleus frequency in bone marrow erythrocytes from the F1 progeny of male mice exposed to chronic low-dose gamma-irradiation was determined. Male BALB/c mice were irradiated with 10, 25 and 50 cGy at dose rates of 1, 5, and 15 cGy/day and mated with unirradiated females on day 15 after irradiation. The obtained offspring had an elevated micronucleus frequency in bone marrow erythrocytes at the age of 2 months. This suggests the transmission of genome instability from damaged germ-line cells of irradiated male parents to somatic cells of the progeny.
Fomenko
L A
LA
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia.
Vasil'eva
G V
GV
Bezlepkin
V G
VG
D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology / Q000502:physiology* / Q000648:ultrastructure; D004912:Erythrocytes / Q000473:pathology / Q000502:physiology* / Q000648:ultrastructure; D005260:Female; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D048629:Micronuclei, Chromosome-Defective / Q000473:pathology*; D015162:Micronucleus Tests; D018812:Paternal Exposure; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000235:genetics*
V éritrotsitakh kostnogo mozga potomstva samtsov mysheĭ, podvergnutykh khronicheskomu gamma-oblucheniiu v malykh dozakh, povyshena chastota mikroiader.