title: A new guaianolide as apoptosis inhibitor from Chrysanthemum boreale.
abstract: The 8-O-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named borenolide, was isolated from Chrysanthemum boreale M. Borenolide inhibits the etoposide-induced apoptosis in U937 cell with an IC(50) value of 6.2 microg/ml. Structural assignment was based on NMR-spectroscopic methods and X-ray crystallographic analysis.
authors.forename: J R
authors.initials: JR
authors.lastname: Lee
authors.forename: M S
authors.initials: MS
authors.lastname: Yang
authors.forename: D S
authors.initials: DS
authors.lastname: Jang
authors.forename: T J
authors.initials: TJ
authors.lastname: Ha
authors.forename: K M
authors.initials: KM
authors.lastname: Park
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
authors.forename: Y H
authors.initials: YH
authors.lastname: Kho
authors.forename: K H
authors.initials: KH
authors.lastname: Park
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020298:U937 Cells
chemical_list: D012717:Sesquiterpenes; C438926:borenolide