title: Effects of autonomic blockers on linear and nonlinear indexes of blood pressure and heart rate in SHR.
abstract: Recent results in normotensive Wistar-Kyoto (WKY) rats show that nonlinear method may be more specific to quantify sympathetic and parasympathetic activities than the low (LF) and high frequencies (HF) spectral powers of blood pressure (BP) and R-R interval (RR). The present study extends this conclusion to spontaneously hypertensive rats (SHR). Blood pressure was recorded for 30 min before and after intravenous injection of saline, hexamethonium, atropine, atenolol, or prazosin. Mean level, standard deviation (SD), spectral LF and HF components, and three nonlinear indexes (percentage of recurrence, percentage of determinism, and length index of the recurrence plot method) were used to analyze the BP and RR signals. In conscious SHR, sympathetic but not parasympathetic blockade reduced BP level and LF-BP, and increased nonlinear indexes of BP. RR increased after beta-sympathetic and ganglionic blockade, decreased after parasympathetic blockade, and remained unchanged after alpha(1)-sympathetic blockade. SD-RR decreased after ganglionic and alpha(1) blockade, whereas HF-RR increased after beta-sympathetic blockade. The effects on nonlinear indexes of RR are clear and consistent: only alpha(1)-blockade increased the indexes. Our nonlinear indexes may be useful to investigate cardiovascular functions in normotension and hypertension.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) U444, Equipe Biostat-Biomath, Université Paris 7-Denis Diderot, 75251 Paris Cedex 05, France. mestiv@urbb.jussieu.fr
authors.forename: D
authors.initials: D
authors.lastname: Mestivier
authors.forename: H
authors.initials: H
authors.lastname: Dabiré
authors.forename: N P
authors.initials: NP
authors.lastname: Chau
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D003971:Diastole; D005730:Ganglionic Blockers / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013565:Sympatholytics / Q000494:pharmacology; D013599:Systole
chemical_list: D000317:Adrenergic alpha-Antagonists; D001337:Autonomic Agents; D005730:Ganglionic Blockers; D010276:Parasympatholytics; D013565:Sympatholytics