title: Regio- and diastereoselective synthesis of 2-alkylidenetetrahydrofurans by domino SN/SN' and SN/SN reactions of 1,3-dicarbonyl dianions.
abstract: The domino C,O-cyclodialkylation reaction of dilithiated 1,3-dicarbonyl compounds with 1,4-dibromo-2-butene resulted in regio- and diastereoselective formation of 2-alkylidene-5-vinyltetrahydrofurans. The cyclization of 1,3-dicarbonyl dianions with 1-bromo-2-chloroethane regio- and diastereoselectively afforded 2-alkylidenetetrahydrofurans under thermodynamic reaction control.
authors.affiliation: Institut für Organische Chemie, Georg-August-Universität, Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany. planger@uni-goettingen.de
authors.forename: P
authors.initials: P
authors.lastname: Langer
authors.forename: E
authors.initials: E
authors.lastname: Holtz
authors.forename: I
authors.initials: I
authors.lastname: Karimé
authors.forename: N N
authors.initials: NN
authors.lastname: Saleh