Late acute thrombosis after paclitaxel eluting stent implantation.
Late (more than six months) total occlusion after coronary stenting is a progressive phenomenon occurring in approximately 4% of patients, leading to acute myocardial infarction in less than 0.5%. The process must be related to severe and progressive intimal hyperplasia. In patients receiving coronary stenting with simultaneous brachytherapy, late total occlusion has been reported at a higher rate and to be related to stent thrombosis rather than intimal hyperplasia. Late total occlusion presenting with an acute clinical event seven months after the implantation of a paclitaxel drug eluting stent is reported. The occlusion developed soon after the interruption of ticlopidine treatment, suggesting that the event had a thrombotic genesis and that the risk is not confined to the first six month period.
Liistro
F
F
Cardiac Catheterisation Laboratory, San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy. francescoliistro@hotmail.com
Colombo
A
A
D000208:Acute Disease; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D001241:Aspirin / Q000627:therapeutic use; D003327:Coronary Disease / Q000188:drug therapy*; D003328:Coronary Thrombosis / Q000209:etiology; D004343:Drug Implants; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012008:Recurrence; D012307:Risk Factors; D015607:Stents; D013988:Ticlopidine / Q000627:therapeutic use; D013997:Time Factors
D020533:Angiogenesis Inhibitors; D004343:Drug Implants; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine; D017239:Paclitaxel; D001241:Aspirin