title: [Diffuse large B-cell lymphoma expressing cytoplasmic IgM and kappa in a patient with lambda-type primary macroglobulinemia].
abstract: A 69-year-old woman who had had lambda-type primary macroglobulinemia (PMG) since December 1993 was admitted in October 1997 because of obstructive jaundice due to compression of the common bile duct by a retroperitoneal tumor. A biopsy sample was obtained by exploratory laparotomy, and from this a diagnosis of diffuse large cell lymphoma (DLCL) expressing cytoplasmic IgM/kappa was made. Partial remission was obtained after 6 courses of combination chemotherapy consisting of pirarubicin, cyclophosphamide, vincristine and prednisolone. However, the DLCL was generally progressive, and the patient died in August 1998 due to multiple organ failure. There was no difference in the plasma monoclonal IgM/lambda level before and during the course of DLCL. The clone of the DLCL may have been different from that of the PMG.
authors.affiliation: First Department of Internal Medicine, Gifu University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Sawada
authors.forename: H
authors.initials: H
authors.lastname: Tsurumi
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Moriwaki
mesh_terms: D000368:Aged; D003593:Cytoplasm / Q000276:immunology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000276:immunology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000276:immunology*; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology*
chemical_list: D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains