Low-dose zinc administration as an effective Wilson's disease treatment.
A case of a 11-yr-long Wilson's disease treatment in a 16-yr-old boy with neurologic presentation was analyzed and monitored. In the face of severe symptoms of chelator intolerance, a comparatively low dose of 100 mg of zinc has been administered for the entire 11-yr-long treatment. Considerable improvement of clinical status was achieved, with accompanying regression of central nervous system lesion. The parameters of copper metabolism were normalized with effective urine elimination. The low-dose oral zinc intake proved to be therapeutically effective, eliminating further copper tissue toxicity.
Najda
J
J
Clinical Department of Internal Diseases and Oncological Chemotherapy, Silesian Medical Academy, Katowice, Poland.
Stella-Hołowiecka
B
B
Machalski
M
M
D000293:Adolescent; D000328:Adult; D003300:Copper / Q000097:blood / Q000378:metabolism / Q000633:toxicity / Q000652:urine; D006527:Hepatolenticular Degeneration / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D006801:Humans; D008297:Male; D013997:Time Factors; D015032:Zinc / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use* / Q000652:urine
D003300:Copper; D015032:Zinc