title: Catabolic and anabolic signals in bone: therapeutic implications.
abstract: Bone remodelling accounts for the continuous renewal of the adult skeleton, and its disturbances constitute the pathophysiological basis of most skeletal disorders. Recently identified bone signalling pathways explain the action of known therapeutic agents and provide targets for new developments in the management of bone diseases.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: S E
authors.initials: SE
authors.lastname: Papapoulos
mesh_terms: D000375:Aging / Q000378:metabolism; D001851:Bone Diseases, Metabolic / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D004164:Diphosphonates / Q000378:metabolism; D006801:Humans; D008798:Mevalonic Acid / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D004164:Diphosphonates; D014409:Tumor Necrosis Factor-alpha; D008798:Mevalonic Acid