The mannan-binding lectin pathway of complement activation: biology and disease association.
Mannan-binding lectin (MBL) is a plasma protein found in association with several serine proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures arranged in a particular geometry, such as those found on the surface of micro-organisms. When bound to e.g. bacteria the MBL complex will initiate the activation of the complement cascade. Mounting evidence supports the importance of the MBL pathway of complement activation in innate immunity. In this review, we focus on the structure and function of the proteins within the MBL pathway and address the properties of the pathway as an initiator of the host response against potential pathogenic micro-organisms.
Petersen
S V
SV
Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK-8000 Aarhus, Denmark. svp@microbiology.au.dk
Thiel
S
S
Jensenius
J C
JC
D000595:Amino Acid Sequence; D001327:Autoimmune Diseases / Q000209:etiology; D001798:Blood Proteins / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D037222:Collectins; D003141:Communicable Diseases / Q000209:etiology; D003167:Complement Activation; D007113:Immunity, Innate; D037102:Lectins / Q000235:genetics / Q000378:metabolism*; D008351:Mannans / Q000276:immunology*; D008969:Molecular Sequence Data
D001798:Blood Proteins; D002352:Carrier Proteins; D037222:Collectins; D037102:Lectins; D008351:Mannans