title: Acute hepatitis C without and with schistosomiasis: correlation with hepatitis C-specific CD4(+) T-cell and cytokine response.
abstract: OBJECTIVE
  Immune responses during the first few months of acute hepatitis C virus (HCV) infection seem crucial for viral control, but the relationship of these responses to natural history is poorly characterized.
  
  
  METHODS
  This prospective study investigated the HCV-specific CD4(+) and cytokine responses in patients with acute HCV hepatitis with or without Schistosoma mansoni coinfection, a parasitic infection with T helper (Th) 2 immune bias. HCV-specific CD4(+) proliferative responses and cytokine production in peripheral blood mononuclear cells were correlated with liver biopsy results at 6 months and at the end of follow-up.
  
  
  RESULTS
  Whereas 5 of 15 patients with HCV alone recovered from acute HCV, all (17 of 17) patients with S. mansoni coinfection progressed to histologically proven chronic hepatitis. Coinfected patients had either absent or transient weak HCV-specific CD4(+) responses with Th0/Th2 cytokine production. The magnitude of the HCV-specific CD4(+) response at week 12 was inversely correlated with the fibrosis progression rate in chronically infected patients.
  
  
  CONCLUSIONS
  Patients with acute hepatitis C and schistosomiasis coinfection cannot clear viremia and show rapid progression once chronic infection is established. This rapid progression is associated with a strong Th2 response in peripheral immune responses, suggesting that early development of vigorous Th1 responses not only facilitates clearance but delays disease progression.
authors.affiliation: Department of Infectious Diseases, Harvard Medical School, Boston, Massachusetts, USA. skamal@ainshams.org
authors.forename: S M
authors.initials: SM
authors.lastname: Kamal
authors.forename: J W
authors.initials: JW
authors.lastname: Rasenack
authors.forename: L
authors.initials: L
authors.lastname: Bianchi
authors.forename: A
authors.initials: A
authors.lastname: Al Tawil
authors.forename: K
authors.initials: K
authors.lastname: El Sayed Khalifa
authors.forename: T
authors.initials: T
authors.lastname: Peter
authors.forename: H
authors.initials: H
authors.lastname: Mansour
authors.forename: W
authors.initials: W
authors.lastname: Ezzat
authors.forename: M
authors.initials: M
authors.lastname: Koziel
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D001706:Biopsy; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D019698:Hepatitis C, Chronic / Q000276:immunology* / Q000469:parasitology* / Q000473:pathology; D006650:Histocompatibility Testing; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D008099:Liver / Q000473:pathology; D008297:Male; D011446:Prospective Studies; D020127:Recovery of Function / Q000276:immunology; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D018417:Th1 Cells / Q000276:immunology / Q000821:virology; D018418:Th2 Cells / Q000276:immunology / Q000821:virology
chemical_list: D016753:Interleukin-10; D007371:Interferon-gamma