title: Stereotactic radiotherapy for solitary brain metastases.
abstract: OBJECTIVE
  Surgery is considered to be the treatment of choice for patients with solitary brain metastases. We report a single-centre experience of stereotactic radiotherapy (SRT)/radiosurgery as an alternative to surgery and define prognostic parameters that provide for a more rational selection of patients for appropriate treatment.
  
  
  METHODS
  Between 1990 and 1997, 96 patients with 106 brain metastases received SRT to a dose of 20 Gy in two fractions (range 20-30 Gy in 24 fractions) either alone or in combination with whole brain radiotherapy.
  
  
  RESULTS
  After SRT, 51% of patients had improvement in neurological function. The median survival of the 96 patients was 9 months. The Radiation Therapy Oncology Group prognostic grouping for patients with multiple brain metastases (prognostic factors: age, performance status, systemic metastases, status of primary tumour) was applicable to this cohort, with median survivals of 15, 8 and 2 months for favourable, intermediate and poor prognostic groups respectively.
  
  
  CONCLUSIONS
  SRT is a non-invasive method of treatment of solitary brain metastases and the outcome is comparable with the results obtained after surgical excision. Prognosis is determined by factors defined for patients with multiple brain metastases, with performance status being the most important. SRT/radiosurgery should be reserved for patients with favourable prognostic factors, with a Karnofsky performance status >70, who have a reasonable chance of good quality prolonged survival. In future trials, radiosurgery should be compared in terms of survival, quality of life and health economics to whole brain radiotherapy and surgery.
authors.affiliation: The Royal Marsden NHS Trust and The Institute of Cancer Research, Sutton, UK.
authors.forename: R
authors.initials: R
authors.lastname: Jyothirmayi
authors.forename: F H
authors.initials: FH
authors.lastname: Saran
authors.forename: R
authors.initials: R
authors.lastname: Jalali
authors.forename: J
authors.initials: J
authors.lastname: Perks
authors.forename: A P
authors.initials: AP
authors.lastname: Warrington
authors.forename: D
authors.initials: D
authors.lastname: Traish
authors.forename: S
authors.initials: S
authors.lastname: Ashley
authors.forename: F
authors.initials: F
authors.lastname: Hines
authors.forename: M
authors.initials: M
authors.lastname: Brada
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D016634:Radiosurgery / Q000379:methods*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome