title: There is no influence of a temperature rise on in vivo adsorption of UV filters into the stratum corneum.
abstract: Temperature influences the stratum corneum adsorption of several topically applied compounds. This study was designed to evaluate the influence of the temperature on the stratum corneum adsorption of 3 UV filters. The UV filters were solubilized in two vehicles, an emulsion gel and petroleum jelly and applied at respectively, 31 and 40 degrees C during 30 min. In vivo stratum corneum UV filter content was measured using the tape stripping method. Similar amounts of UV filter were detected in the stratum corneum when comparing applications at the different temperatures. Application of the UV filters in the emulsion gel resulted in higher stratum corneum UV filter concentrations compared with application in the petroleum jelly. The application temperature did not influence the stratum corneum adsorption of the tested UV filters while the nature of the vehicle significantly influenced the amount of UV filters recovered from the stratum corneum.
authors.affiliation: Department of General and Biological Chemistry, Faculty for Physical Education and Physiotherapy, Vrije Universiteit Brussel, ABIS Room 6G304, Pleinlaan 2, 1050 Brussels, Belgium. pclarys@vub.ac.be
authors.forename: P
authors.initials: P
authors.lastname: Clarys
authors.forename: B
authors.initials: B
authors.lastname: Gabard
authors.forename: R
authors.initials: R
authors.lastname: Lambrecht
authors.forename: A
authors.initials: A
authors.lastname: Barel
authors.forename: E
authors.initials: E
authors.lastname: Bieli
authors.forename: S
authors.initials: S
authors.lastname: Lüdi
mesh_terms: D000328:Adult; D001577:Benzophenones / Q000494:pharmacology*; D002934:Cinnamates / Q000494:pharmacology*; D004655:Emulsions; D005782:Gels; D006801:Humans; D006813:Humidity; D010577:Petrolatum; D015203:Reproducibility of Results; D012459:Salicylates / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D012879:Skin Physiological Phenomena; D013473:Sunscreening Agents / Q000494:pharmacology*; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D001577:Benzophenones; D002934:Cinnamates; D004655:Emulsions; D005782:Gels; D012459:Salicylates; D013473:Sunscreening Agents; C103422:2-ethylhexyl salicylate; C118580:octylmethoxycinnamate; D010577:Petrolatum; C005290:oxybenzone