[Impact of menopause and disease on osteocalcin markers in female patients with rheumatoid arthritis].
The impact of menopause and activity of rheumatoid inflammation on the osseous tissue metabolism was studied with the aid of biochemical markers of remodelling of the osseous tissue. Osteocalcin (noncollagenous protein of bone tissue) is believed to be the most informative marker of formation of the osseous tissue. In 70 female patients presenting with rheumatoid arthritis, blood serum concentration of osteocalcin was measured. Of these, 37 were in their premenopause, 33--in postmenopause. The control group was 26 female subjects. The activity of the rheumatoid process in premenopausal period and during the postmenopausal second and third five-year periods was found out to be associated with the rate of processes of bone tissue formation. At menopause the blood content of osteocalcin gets increased but subsequently it is noted to be on the decrease.
Mytnyk
Z M
ZM
Holovach
I Iu
IIu
D001172:Arthritis, Rheumatoid / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*
D015415:Biomarkers; D015675:Osteocalcin
Vplyv menopauzy aktyvnosti zakhvoriuvannia na pokaznyky osteokal'tsynu v zhinok, khvorykh na revmatoïdnyĭ artryt.