Maternal deprivation increases 5-HT(1A) receptor expression in the CA1 and CA3 areas of senescent Brown Norway rats.
Maternally-deprived male Brown Norway rats were classified as non-impaired or impaired according to their performance in the water maze when 3 and 30-32 months old. Age and spatial learning ability did not affect the pattern and density of hippocampal 5-HT(1A)-receptor mRNA in mother-reared control rats. However, senescent maternally-deprived rats with impaired spatial learning ability showed increased expression of 5-HT(1A)-receptor mRNA in the hippocampal CA1 (14%) and CA3 (13%) areas but not in the dentate gyrus.
Sibug
R M
RM
Leiden/Amsterdam Center for Drug Research and Leiden University Medical Center, Division of Medical Pharmacology, University of Leiden, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands. r.sibug@lacdr.leidenuniv.nl
Oitzl
M S
MS
Workel
J O
JO
de Kloet
E R
ER
D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D003072:Cognition Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006624:Hippocampus / Q000378:metabolism* / Q000503:physiopathology; D008426:Maternal Deprivation; D018782:Maze Learning / Q000502:physiology; D009474:Neurons / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011985:Receptors, Serotonin / Q000235:genetics*; D044263:Receptors, Serotonin, 5-HT1; D012701:Serotonin / Q000378:metabolism; D013312:Stress, Physiological / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D015854:Up-Regulation / Q000502:physiology*
D000305:Adrenal Cortex Hormones; D012333:RNA, Messenger; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012701:Serotonin