title: Tongue atrophy in facioscapulohumeral muscular dystrophy.
abstract: Involvement of the lingual muscle is considered one of the exclusion criteria of facioscapulohumeral muscular dystrophy (FSHD). In a series of 151 Japanese patients with 4q35-FSHD, seven patients (4.6%) had tongue atrophy with abnormal MRI findings and typical myogenic patterns of electromyography. All seven patients belong to a group of early-onset FSHD with large gene deletions on chromosome 4q35. Our result suggests that the patients with 4q35-FSHD could have myopathic tongue atrophy.
authors.affiliation: Department of Neuromuscular Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Yamanaka
authors.forename: K
authors.initials: K
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: M
authors.initials: M
authors.lastname: Funakoshi
authors.forename: T
authors.initials: T
authors.lastname: Komori
authors.forename: Y K
authors.initials: YK
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Arahata
mesh_terms: D000293:Adolescent; D000328:Adult; D001284:Atrophy; D002648:Child; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D004576:Electromyography; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020391:Muscular Dystrophy, Facioscapulohumeral / Q000235:genetics / Q000473:pathology*; D014059:Tongue / Q000473:pathology*