Association of primary pleural effusion lymphoma of T-cell origin and human herpesvirus 8 in a human immunodeficiency virus-seronegative man.
We describe a case of an 87-year-old human immunodeficiency virus (HIV)-negative man who developed a primary pleural lymphoma without any identifiable tumor mass associated with human herpesvirus 8 (HHV-8) infection. A large T-cell lymphoma was diagnosed based on morphologic, immunophenotypic, and molecular findings. The HHV-8 DNA sequences were detected using specific polymerase chain reaction amplification in the lymphomatous effusion. Study of the patient's serum confirmed the HHV-8 infection. This case report displays the characteristic features of HHV-8-related body cavity-based lymphoma/primary effusion lymphoma previously reported in HIV-seronegative patients, except that it is of T-cell origin. Whether this case may be included or not within the primary effusion lymphoma entity, the association of a pleural T-cell non-Hodgkin lymphoma with HHV-8 infection raises the question of the possible occurrence of T cells as the target of malignant transformation associated with HHV-8 infection.
Lechapt-Zalcman
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E
Département de Pathologie Hôpital Henri Mondor, Créteil, France. emmanuele.lechapt@hmn.ap-hop-paris.fr
Challine
D
D
Delfau-Larue
M H
MH
Haioun
C
C
Desvaux
D
D
Gaulard
P
P
D000368:Aged; D000369:Aged, 80 and over; D000462:Algeria / Q000208:ethnology; D015703:Antigens, CD / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D005602:France; D018023:HIV Seronegativity; D006566:Herpesviridae Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D008297:Male; D010996:Pleural Effusion / Q000276:immunology / Q000473:pathology* / Q000821:virology; D016133:Polymerase Chain Reaction
D015703:Antigens, CD; D004279:DNA, Viral