title: A four-day study to evaluate the anti-plaque efficacy of an experimental triclosan-containing dentifrice.
abstract: Four-day, non-brushing studies have been used successfully to demonstrate the anti-plaque efficacy of triclosan-containing dentifrices. The treatment effects observed are variable, likely due to differences in formulation, study design and measurement techniques. This randomized, double-blind crossover study was conducted to evaluate the anti-plaque efficacy of an experimental, multiple-benefit, triclosan-containing dentifrice versus two currently marketed sodium fluoride dentifrices in a four-day, lingual-brushing model on subjects in Beijing. People's Republic of China. Subjects brushed the lingual surfaces for 30 seconds, and before expectorating, swished the saliva/dentifrice slurry over the buccal surfaces for an additional 30 seconds. This procedure was repeated. Subjects performed their assigned brushing regimen twice daily for four days under supervision. On Day 5, plaque was measured using the Turesky Modification of the Quigley-Hein Plaque Index. There were highly significant treatment effects in favor of the experimental triclosan-containing dentifrice for whole mouth, buccal and lingual sites when compared to either of the sodium fluoride dentifrices (p < 0.0001).
authors.affiliation: Peking University, School of Stomatology, Beijing, People's Republic of China.
authors.forename: C
authors.initials: C
authors.lastname: Cao
authors.forename: Y
authors.initials: Y
authors.lastname: Sha
authors.forename: H
authors.initials: H
authors.lastname: Meng
authors.forename: J
authors.initials: J
authors.lastname: Kang
authors.forename: C H
authors.initials: CH
authors.lastname: Yeh
authors.forename: H Y
authors.initials: HY
authors.lastname: Chyon
authors.forename: J L
authors.initials: JL
authors.lastname: Winston
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002681:China; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D012449:Safety; D016037:Single-Blind Method; D012969:Sodium Fluoride / Q000627:therapeutic use; D014099:Toothbrushing; D014260:Triclosan / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D014260:Triclosan; D012969:Sodium Fluoride