A-fibres sprouting from lamina I into lamina II of spinal dorsal horn after peripheral nerve injury in rats.
We have examined the labeling pattern in the spinal dorsal horn by an intra-sciatic nerve injection of cholera toxin B subunit conjugated horseradish peroxidase (HRP) after transection of the posterior cutaneous nerve and inferior gluteal nerve, and found that the cholera toxin B subunit conjugated HRP labeling in lamina I was expanding into lamina II and there was a shrinking gap between lamina I and lamina III. This result suggests that A-fibre sprouting arise after peripheral nerve injury, but mainly from small calibre Adelta-fibres which terminate in lamina I.
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Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK. quingping_ma@merck.com
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D000344:Afferent Pathways / Q000473:pathology* / Q000502:physiology; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects / Q000502:physiology; D019771:Axotomy; D002772:Cholera Toxin / Q000493:pharmacokinetics; D006735:Horseradish Peroxidase / Q000493:pharmacokinetics; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology* / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D010523:Peripheral Nervous System Diseases / Q000473:pathology / Q000503:physiopathology*; D020671:Posterior Horn Cells / Q000473:pathology* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D002772:Cholera Toxin; D006735:Horseradish Peroxidase