title: Thrombolytic therapy for adhesion of percutaneous central venous catheters to vein intima associated with Malassezia furfur Infection.
abstract: OBJECTIVE
  To report our experience with thrombolytic agents in the management of two infants with silicone central venous catheters that had adhered to the vein wall as a result of infection with Malassezia furfur.
  
  
  METHODS
  Case review of two very low birth weight infants with adherent central venous catheters.
  
  
  RESULTS
  Treatment with urokinase and tissue plasminogen activator facilitated the removal of these catheters without breakage or surgical intervention.
  
  
  CONCLUSIONS
  Thrombolytic agents should be considered as a treatment of adhered catheters, as well as of occluded catheters.
authors.affiliation: Arizona College of Osteopathic Medicine, Glendale, AZ, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Nguyen
authors.forename: C H
authors.initials: CH
authors.lastname: Lund
authors.forename: D J
authors.initials: DJ
authors.lastname: Durand
mesh_terms: D002408:Catheters, Indwelling / Q000382:microbiology*; D003881:Dermatomycoses / Q000188:drug therapy*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008290:Malassezia; D008297:Male; D010289:Parenteral Nutrition, Total; D012828:Silicones; D015912:Thrombolytic Therapy; D000267:Tissue Adhesions; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage; D017539:Tunica Intima; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
chemical_list: D005217:Fat Emulsions, Intravenous; D012828:Silicones; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator