title: Birth of a healthy girl after ICSI with ejaculated spermatozoa from a man with non-mosaic Klinefelter's syndrome.
abstract: Klinefelter's syndrome is a major contributor to male infertility. Recent reports of births after ICSI with especially testicular spermatozoa from infertile men with this syndrome are promising. The birth of a healthy girl after ICSI treatment with ejaculated spermatozoa from a man with non-mosaic Klinefelter's syndrome is reported. The non-mosaic karyotype was confirmed by chromosome analysis of both peripheral blood leukocytes and fibroblasts from a skin biopsy. In conclusion, in a very few cases, men with apparently non-mosaic Klinefelter's syndrome have ejaculated spermatozoa that can result in a birth of a healthy child following ICSI.
authors.affiliation: Department of Clinical Genetics, Vejle Hospital, DK-7100 Vejle, Denmark. dgc@vs.vejleamt.dk
authors.forename: D
authors.initials: D
authors.lastname: Crüger
authors.forename: B
authors.initials: B
authors.lastname: Toft
authors.forename: I
authors.initials: I
authors.lastname: Agerholm
authors.forename: J
authors.initials: J
authors.lastname: Fedder
authors.forename: F
authors.initials: F
authors.lastname: Hald
authors.forename: G
authors.initials: G
authors.lastname: Bruun-Petersen
mesh_terms: D000328:Adult; D004542:Ejaculation; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D007713:Klinefelter Syndrome / Q000235:genetics* / Q000503:physiopathology*; D007743:Labor, Obstetric; D008297:Male; D009030:Mosaicism; D011247:Pregnancy; D012016:Reference Values; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000502:physiology*