Leishmanicidal activity of some stilbenoids and related heterocyclic compounds.
We have evaluated the leishmanicidal activity of some natural and semisynthetic dihydrostilbenoids and several compounds of other series of dihydrostilbamides, isoindoles, phthalazinones, imidazoisoindoles and pyrimidoisoindoles. The evaluation was performed in vitro, on cultures of cutaneous, mucocutaneous and visceral strains of Leishmania spp. The most potent and selective compounds of these series were the dihydrostilbene piperidides.
del Olmo
E
E
Departamento de Química Farmacéutica, Facultad de Farmacia, 37007, Salamanca, Spain. olmo@gugu.usal.es
Armas
M G
MG
López-Pérez
J L
JL
Muñoz
V
V
Deharo
E
E
San Feliciano
A
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D006571:Heterocyclic Compounds; D007093:Imidazoles; D007211:Indoles; D013267:Stilbenes