title: Phenytoin-induced lingual tonsil hyperplasia causing laryngeal obstruction.
abstract: The effects of phenytoin sodium on lymphoid tissue have been known for some time. However, its effect on the lymphoid tissue of Waldeyer's ring is unreported in the otolaryngology literature. We present the case of a 78-year-old woman who was treated with phenytoin for generalized tonic-clonic seizures for 4 months and who subsequently developed lingual hyperplasia that caused laryngeal obstruction eventually requiring a tracheotomy. Of note, no history of airway compromise or difficulty with intubation from a prior operation 20 years ago was reported; these findings suggest that the lingual tonsillar hyperplasia was a consequence of phenytoin therapy and not a preexisting condition. The findings of histopathologic evaluation were consistent with lymphoid hyperplasia without evidence of malignancy. We also report our operative management and follow-up of this rare condition.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: W M
authors.initials: WM
authors.lastname: Ralph
authors.forename: S K
authors.initials: SK
authors.lastname: Huh
authors.forename: H
authors.initials: H
authors.lastname: Kim
mesh_terms: D000368:Aged; D000402:Airway Obstruction / Q000209:etiology*; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007829:Laryngostenosis / Q000209:etiology*; D014066:Palatine Tonsil / Q000187:drug effects / Q000473:pathology*; D010672:Phenytoin / Q000009:adverse effects*; D014059:Tongue; D014068:Tonsillectomy
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin