title: Protein stability: the COP9 signalosome gets in on the act.
abstract: The COP9 signalosome is a multiprotein complex somewhat similar to the lid component of the 26S proteasome. Recent studies suggest that it regulates the stability of proteins by interfering with the ubiquitin-proteasome pathway via deneddylation and phosphorylation.
authors.affiliation: MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. Michael.Seeger@hgu.mrc.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Seeger
authors.forename: C
authors.initials: C
authors.lastname: Gordon
authors.forename: W
authors.initials: W
authors.lastname: Dubiel
mesh_terms: D000075686:COP9 Signalosome Complex; D046911:Macromolecular Substances; D008954:Models, Biological; D046912:Multiprotein Complexes; D010447:Peptide Hydrolases; D010766:Phosphorylation; D010940:Plant Proteins / Q000378:metabolism; D021122:Protein Subunits; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D046911:Macromolecular Substances; D046912:Multiprotein Complexes; D010940:Plant Proteins; D021122:Protein Subunits; D011506:Proteins; D014452:Ubiquitins; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex