title: Synthesis and biological evaluation of L- and D-configurations of 2',3'-dideoxy-4'-C-methyl-3'-oxacytidine analogues.
abstract: Novel L- and D-configuration 2',3'-dideoxy-4'-C-methyl-3'-oxacytidine and their 5-fluoro analogues have been synthesized from 1-benzyloxy-2-propanone and L-ascorbic acid in eight steps and evaluated for biological activity.
authors.affiliation: Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520-8066, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Liu
authors.forename: M Z
authors.initials: MZ
authors.lastname: Luo
authors.forename: D E
authors.initials: DE
authors.lastname: Mozdziesz
authors.forename: T S
authors.initials: TS
authors.lastname: Lin
authors.forename: G E
authors.initials: GE
authors.lastname: Dutschman
authors.forename: E A
authors.initials: EA
authors.lastname: Gullen
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheng
authors.forename: A C
authors.initials: AC
authors.lastname: Sartorelli
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003562:Cytidine / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D003562:Cytidine