Anti-Gal-C antibodies in GBS subsequent to mycoplasma infection: evidence of molecular mimicry.
The authors previously reported the presence of antibody against galactocerebroside (Gal-C) in sera from patients with Guillain-Barré syndrome subsequent to Mycoplasma pneumoniae infection. Anti-Gal-C antibody activities in these sera were inhibited specifically by the M. pneumoniae reagent. A rabbit anti-Gal-C antibody recognized several glycolipids in M. pneumoniae. These data show that a Gal-C-like structure is present in M. pneumoniae, indicative of molecular mimicry between a major myelin glycolipid, Gal-C, and M. pneumoniae.
Kusunoki
S
S
Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan. kusunoki-tky@umin.ac.jp
Shiina
M
M
Kanazawa
I
I
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D005699:Galactosylceramides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D018716:Molecular Mimicry; D011019:Pneumonia, Mycoplasma / Q000276:immunology*; D011817:Rabbits
D001323:Autoantibodies; D005699:Galactosylceramides; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C002454:galactocerebroside