Mapping quantitative trait loci for circadian behavioral rhythms in SMXA recombinant inbred strains.
SM/J and A/J inbred strain of mice have different characteristics in circadian behaviors such as free-running period (tau), phase relationship (psi) between light-dark cycles and activity rhythms, and amount of wheel-running activity. To determine the genes which affect these behaviors, a quantitative trait locus (QTL) analysis using SMXA recombinant inbred strains derived from SM/J and A/J mice was performed. Concerning tau, two regions on chromosomes (Chrs) 7 and 18 surpassed the genome-wide suggestive level. As for psi, one suggestive QTL was detected on Chr 7. The QTLs which affect daily activity counts under light-dark cycles and constant darkness were mapped to the same chromosomal regions on Chrs 1 and 17, respectively. The provisional QTLs detected in the present study might be useful for understanding the complex mechanism regulating circadian behaviors.
Suzuki
T
T
Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
Ishikawa
A
A
Nishimura
M
M
Yoshimura
T
T
Namikawa
T
T
Ebihara
S
S
D000818:Animals; D002874:Chromosome Mapping; D002940:Circadian Rhythm / Q000235:genetics*; D005260:Female; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008815:Mice, Inbred Strains; D009043:Motor Activity; D019655:Quantitative Trait, Heritable; D011995:Recombination, Genetic