Control of developmental timing in animals.
The molecular mechanisms that time development are now being deciphered in various organisms, particularly in Caenorhabditis elegans. Key recent findings indicate that certain C. elegans timekeeping genes are conserved across phyla, and their developmental expression patterns indicate that a timing function might also be conserved. Small regulatory RNAs have crucial roles in the timing mechanism, and the cellular machinery required for production of these RNAs intersects with that used to process double-stranded RNAs during RNA interference.
Rougvie
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Department of Genetics, University of Minnesota, 1445 Gortner Avenue, St Paul, Minnesota 55108, USA. rougvie@biosci.cbs.umn.edu
D000818:Animals; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000235:genetics / Q000254:growth & development*; D018510:RNA, Helminth / Q000502:physiology
D018510:RNA, Helminth