Bisphenol-A differently affects estrogen receptors-alpha in estrous-cycling and lactating female rats.
The effect of long-term exposure to bisphenol-A (BPA) on estrogen receptor-alpha (ER) immunoreactivity was studied in the medial preoptic area, arcuate nucleus and the ventromedial nucleus of the hypothalamus of estrous cycling and lactating female rats. Pregnant/lactating or estrous cycling rats were exposed to BPA (40 mg/Kg/day) or peanut oil. Lactating females showed fewer ER-immunoreactive cells than non-lactating females in the medial preoptic area and ventromedial nucleus of the hypothalamus. BPA induced an increase in ER-immunoreactive cells in the medial preoptic nucleus irrespective of lactation. BPA only induced a decrease in ER-immunoreactive cells in the arcuate nucleus of the lactating group; oil induced an increase in ER-immunoreactive cells in the lactating with respect to non-lactating group. The results demonstrate that exposure of adult females to BPA modifies the number of ERs.
Aloisi
A M
AM
Institute of Human Physiology, University of Siena, Via Aldo Moro, 53100, Siena, Italy. aloisi@unisi.it
Della Seta
D
D
Ceccarelli
I
I
Farabollini
F
F
D000818:Animals; D001559:Benzhydryl Compounds; D001923:Brain Chemistry / Q000187:drug effects; D001931:Brain Mapping; D002452:Cell Count; D047628:Estrogen Receptor alpha; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D004971:Estrus / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D007774:Lactation / Q000502:physiology*; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000502:physiology*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D047628:Estrogen Receptor alpha; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D011960:Receptors, Estrogen; C006780:bisphenol A; D000098826:Bisphenol A Compounds