[Neurite-stimulating effect of Hirudo medicinalis salivary gland secreting factors in organotypic culture of the dorsal root ganglia].
Effects of destabilise, bdellin, bdellin A, eglin were investigated in organotypic tissue culture of dorsal root ganglia (DRG) of 10-11-day old chick embryos. Native destabilase and bdellin A, bdellin B and eglin are more active inducing a more intensive neurite growth in DRG as compared with the control. A neurite-stimulating effect of the drug "pyjavit" seems to be associated with destabilase, bdellins and eglin neurite-stimulating activity.
Chalisova
N I
NI
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Baskova
I P
IP
Zavalova
L L
LL
Pennijainen
V A
VA
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D002642:Chick Embryo; D010450:Endopeptidases / Q000302:isolation & purification / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000502:physiology; D007865:Leeches / Q000737:chemistry; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D009924:Organ Culture Techniques; D009930:Organic Chemicals; D011480:Protease Inhibitors / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology; D012469:Salivary Glands; D015843:Serpins
D001685:Biological Factors; D009930:Organic Chemicals; D011480:Protease Inhibitors; D011506:Proteins; D015843:Serpins; C028656:eglin proteinase inhibitors; C107927:bdellin; D010450:Endopeptidases; C045348:fibrin destabilase
Neĭritstimuliruiushchee vliianie komponentov sekreta sliunnykh zhelez meditsinskoĭ piiavki v organotipicheskoĭ kul'ture spinnomozgovykh gangliev.