Significant role of interleukin-8 in pathogenesis of pulmonary disease due to Mycoplasma pneumoniae infection.
We found elevated levels of interleukin-8 in pleural fluid samples from patients with pleural effusion and with a sustained fibrotic change of the lung due to Mycoplasma pneumoniae infection. This result suggests a critical role of interleukin-8 in the pathogenesis of a certain type of pulmonary disease caused by M. pneumoniae.
Narita
M
M
Department of Pediatrics, Sapporo Tetsudo (JR) Hospital, N3 E1 Chuo-ku, Sapporo 060-0033, Japan. naritamy@d5.dion.ne.jp
Tanaka
H
H
Yamada
S
S
Abe
S
S
Ariga
T
T
Sakiyama
Y
Y
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D016209:Interleukin-8 / Q000097:blood / Q000502:physiology*; D009177:Mycoplasma pneumoniae / Q000302:isolation & purification*; D011019:Pneumonia, Mycoplasma / Q000276:immunology* / Q000382:microbiology*; D016212:Transforming Growth Factor beta / Q000097:blood; D053773:Transforming Growth Factor beta1
D016209:Interleukin-8; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1