Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeldt-Jakob disease.
CSF 14-3-3 and neuron-specific enolase (NSE) proteins were quantitated from patients who had Creutzfeldt-Jakob disease (CJD) or other rapidly dementing disorders initially considered to be CJD. Thirty-one patients were diagnosed as having CJD among 152 studied. CSF 14-3-3 values more than 8 ng/mL correlated with CJD. CSF NSE values less than 30 ng/mL and 14-3-3 values less than 8 ng/mL made a diagnosis of CJD unlikely, but did not exclude it.
Aksamit
A J
AJ
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Preissner
C M
CM
Homburger
H A
HA
D048948:14-3-3 Proteins; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*; D012189:Retrospective Studies; D014446:Tyrosine 3-Monooxygenase / Q000134:cerebrospinal fluid*
D048948:14-3-3 Proteins; D014446:Tyrosine 3-Monooxygenase; D010751:Phosphopyruvate Hydratase