Some blood biochemistry parameters during the cholinergic treatment of Alzheimer's disease.
Acetylcholinesterase (ACE) activity and lipid peroxidation (LPO) parameters were measured in the blood of patients with Alzheimer's disease (AD) during treatment with amiridine and gliatiline. Treatment was accompanied by inhibition of ACE. There was a statistically significant relationship between clinical efficacy and changes in ACE activity. AD was charactefized by significant changes in LPO parameters, with a three-fold increase in the level of primary oxidation products on the background of a sharp (seven-fold) increase in total lipid desaturatedness. There was a statistically significant relationship between ACE activity and the levels of primary oxidation products in the RBC of patients with AD before and after treatment with amiridine and gliatiline.
Braginskaya
F I
FI
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow.
Zorina
M
M
Pal'mina
N P
NP
Gaintseva
V D
VD
Burlakova
E B
EB
Selezneva
N D
ND
Kolykhalov
I V
IV
Gavrilova
S I
SI
D000110:Acetylcholinesterase / Q000097:blood; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000188:drug therapy*; D000634:Aminoquinolines; D002091:Butyrylcholinesterase / Q000097:blood; D018678:Cholinergic Agents / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000097:blood / Q000201:enzymology; D018696:Neuroprotective Agents / Q000627:therapeutic use
D000634:Aminoquinolines; D018678:Cholinergic Agents; D002800:Cholinesterase Inhibitors; D018696:Neuroprotective Agents; C049860:amiridine; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase