title: 14-3-3 protein in the CSF as prognostic marker in early multiple sclerosis.
abstract: Axonal damage probably occurs early in the evolution of MS. Five of 38 (13%) patients had a positive assay for the neuronal 14-3-3 protein in the CSF obtained at the first clinically isolated syndrome suggestive of MS. A positive 14-3-3 assay was the only independent predictor for a shorter time to conversion to clinical definite MS (risk ratio 4.1; 95% CI 1.1 to 15) and to reach an Expanded Disability Status Scale (EDSS) > or =2 at the end of follow-up (odds ratio 14.8; 95% CI 2.86 to 76.8). The detection of the 14-3-3 protein in the CSF at the first neurologic event suggestive of MS may be a useful predictor of short-term evolution.
authors.affiliation: Service of Neurology, Ciutat Sanitaria Universitaria de Bellvitge, L'Hospitalet, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Martínez-Yélamos
authors.forename: A
authors.initials: A
authors.lastname: Saiz
authors.forename: R
authors.initials: R
authors.lastname: Sanchez-Valle
authors.forename: V
authors.initials: V
authors.lastname: Casado
authors.forename: J M
authors.initials: JM
authors.lastname: Ramón
authors.forename: F
authors.initials: F
authors.lastname: Graus
authors.forename: T
authors.initials: T
authors.lastname: Arbizu
mesh_terms: D048948:14-3-3 Proteins; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014446:Tyrosine 3-Monooxygenase / Q000134:cerebrospinal fluid*
chemical_list: D048948:14-3-3 Proteins; D015415:Biomarkers; D014446:Tyrosine 3-Monooxygenase