Successful treatment of hepatosplenic candidiasis in an elderly patient with acute myeloid leukemia using liposomal daunorubicin and fluconazole.
Fungal infections are an increasing cause of morbidity and mortality in patients with haematological malignancies. The organism most often responsible are Candida spp., particurarly Candida Albicans. This report describes our experience in a 63-year-old man who developed symptoms of hepatosplenic candidiasis caused by Candida tropicalis after treatment for acute myeloid leukaemia (AML). The fungal infection was successfully controlled using fluconazole, and the patient has been disease-free for more than 11 months after antileukemic chemotherapy without any recurrence of Candida infections. Our experience suggests that AML and chemotherapy associated fungal infections can be controlled with an appropriate therapeutic regimen.
Quintini
G
G
Barbera
V
V
Gambino
R
R
Spadola
V
V
Minardi
V
V
Mariani
G
G
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002177:Candidiasis / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D003630:Daunorubicin / Q000008:administration & dosage*; D018572:Disease-Free Survival; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy / Q000821:virology; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications*; D008081:Liposomes; D008107:Liver Diseases / Q000188:drug therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D008081:Liposomes; D015725:Fluconazole; D003630:Daunorubicin