Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses.
Lsc (the murine homolog of human p115 Rho GEF) is a member of the Dbl-homology family of GTP exchange factors and is a specific activator of Rho. Lsc is activated by the G alpha(13) subunit of heterotrimeric G proteins and contains a regulator of G protein signaling domain that downmodulates G alpha(12) and G alpha(13). Lsc is expressed primarily in the hematopoietic system and links the activation of G alpha(12) and G alpha(13)-coupled receptors to actin polymerization in B and T cells. Lsc is essential for marginal zone B (MZB) cell homeostasis and for the generation of immune responses. Although Lsc-deficient lymphocytes show reduced basal motility, MZB cells show enhanced migration after serum activation. Thus, Lsc is a critical regulator of MZB cells and immune functions.
Girkontaite
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Abteilung Physiologische Chemie, Universität Ulm, Albert-Einstein-Allee 11, D-89069 Ulm, Germany.
Missy
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Sakk
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Harenberg
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Tedford
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Pötzel
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Pfeffer
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Fischer
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D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte; D004268:DNA-Binding Proteins / Q000378:metabolism; D044365:GTP-Binding Protein alpha Subunits, G12-G13; D018390:Gene Targeting; D020662:Guanine Nucleotide Exchange Factors; D006412:Hematopoietic Stem Cells / Q000276:immunology; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D007136:Immunoglobulins / Q000096:biosynthesis; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000145:classification; D008221:Lymphoid Tissue / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D010974:Platelet Aggregation; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D011995:Recombination, Genetic; D064067:Rho Guanine Nucleotide Exchange Factors; D014018:Tissue Distribution
C577231:Arhgef1 protein, mouse; D004268:DNA-Binding Proteins; D020662:Guanine Nucleotide Exchange Factors; D007136:Immunoglobulins; D011518:Proto-Oncogene Proteins; D064067:Rho Guanine Nucleotide Exchange Factors; D044365:GTP-Binding Protein alpha Subunits, G12-G13; D020962:Heterotrimeric GTP-Binding Proteins