title: Hydatid disease of the liver in childhood: the success of medical therapy and surgical alternatives.
abstract: Hydatid liver disease in children is a serious problem where the parasite is endemic. Although surgery is considered the treatment of choice, medical therapy is an alternative, but its curative efficacy is controversial. The aims of this study were to evaluate the curative efficacy of medical treatment and compare the results of surgical techniques with respect to postoperative complications in 102 consecutive children (64 male and 38 female, aged 4 to 15 years, mean 8.15 years) treated in two children's hospitals between 1988 and 1997. In 67, medication with albendazole was used as the initial therapy; 17 had multiple hepatic cysts and 8 had coexisting cysts in the lung. Success was defined as progressive shrinkage and solidification of the cyst. The overall success of medical therapy was approximately 27%: 18 of the 67 patients were cured with albendazole (15 had a single cyst, 3 multiple cysts) and 1 recurrence (6%) was observed. Age, sex, and the size, location, and number of cysts did not show any relationship to the response to medical therapy. After 12 to 14 weeks of medical treatment, a viable cyst on ultrasonography and/or computed tomography was accepted as a sign of treatment failure and these patients were scheduled for surgery. A total of 84 patients (35 primarily, 49 after unsuccessful medical therapy) were treated surgically. Procedures included cystectomy and tube drainage in 11 patients, cystectomy in 17, cystectomy and capitonnage in 24, and cystectomy and omentoplasty in 32. The incidence of early postoperative complications was 55% for tube drainage, 18% for cystectomy, 13% for capitonnage, and 0% for omentoplasty. During the follow-up period, 2 surgical patients (2%) developed recurrent disease. Medical treatment with albendazole resulted in fewer curative successes than expected. A longer period of medical treatment may increase the success rate; this question requires further study. Omentoplasty decreased the rate of early postoperative complications, especially cavity abscess and biliary fistula, after surgical treatment and should be recommended in this setting.
authors.affiliation: Social Security Institution, Ankara Children's Hospital, Department of Pediatric Surgery, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Demirbilek
authors.forename: S
authors.initials: S
authors.lastname: Sander
authors.forename: H F
authors.initials: HF
authors.lastname: Atayurt
authors.forename: G
authors.initials: G
authors.lastname: Aydin
mesh_terms: D000293:Adolescent; D015766:Albendazole / Q000627:therapeutic use; D000923:Anticestodal Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004444:Echinococcosis, Hepatic / Q000000981:diagnostic imaging / Q000601:surgery* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology; D014463:Ultrasonography
chemical_list: D000923:Anticestodal Agents; D015766:Albendazole