[Mechanisms of the effect of circulating neutrophils (granulocytes) in the response of a release reaction of human platelets].
Studied singularities of development platelet release reaction, as of functional activity platelets, at direct effect contents of cytoplasmic granular structures circulating neutrophile leucocytes (granulocytes), possessing a potential capability to selective exocytosis. The model researches were conducted in a system in vitro on isolated viable non active of platelets practically of healthy people. As possible activators the subpopulations them of cytoplasmic granules, distinguished on morphological and enzymetion to indications were applied, previously chosen by methods of an analytical centrifuging from donor neutrophile granulocytes. The development platelets of a response of a release was determined on dynamics quantitative reorganization in platelets an alpha-granules and change of activity in out of platelets to environment of the factor 4 platelets. The capability of a dominance lysosomal initiators neutrophile granulocytes in development of a response of a release of platelets was installed. The scheme of probable trigger participation circulating of neutrophile granulocytes in development syndrome disseminated intravascular coagulation.
Koval'
S B
SB
Bogomoletz Institute of Physiology, NAS Ukraine, Kiev.
Seredenko
M M
MM
Lunina
N V
NV
D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology*; D003594:Cytoplasmic Granules / Q000502:physiology; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000503:physiopathology; D005089:Exocytosis; D006098:Granulocytes / Q000166:cytology / Q000201:enzymology / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008954:Models, Biological; D010978:Platelet Factor 4 / Q000502:physiology
D010978:Platelet Factor 4
Mekhanizmy vplyvu tsyrkuliuiuchykh neĭtrophil'nykh hranulotsytiv na reaktsiiu vyvil'nennia iz trombotsytiv krovi liudyny.