title: 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).
abstract: 1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.
authors.affiliation: GlaxoSmithKline Pharmaceuticals, Antibacterials and Host Defense, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. dirk_a_heerding@sbphrd.com
authors.forename: D A
authors.initials: DA
authors.lastname: Heerding
authors.forename: G
authors.initials: G
authors.lastname: Chan
authors.forename: W E
authors.initials: WE
authors.lastname: DeWolf
authors.forename: A P
authors.initials: AP
authors.lastname: Fosberry
authors.forename: C A
authors.initials: CA
authors.lastname: Janson
authors.forename: D D
authors.initials: DD
authors.lastname: Jaworski
authors.forename: E
authors.initials: E
authors.lastname: McManus
authors.forename: W H
authors.initials: WH
authors.lastname: Miller
authors.forename: T D
authors.initials: TD
authors.lastname: Moore
authors.forename: D J
authors.initials: DJ
authors.lastname: Payne
authors.forename: X
authors.initials: X
authors.lastname: Qiu
authors.forename: S F
authors.initials: SF
authors.lastname: Rittenhouse
authors.forename: C
authors.initials: C
authors.lastname: Slater-Radosti
authors.forename: W
authors.initials: W
authors.lastname: Smith
authors.forename: D T
authors.initials: DT
authors.lastname: Takata
authors.forename: K S
authors.initials: KS
authors.lastname: Vaidya
authors.forename: C C
authors.initials: CC
authors.lastname: Yuan
authors.forename: W F
authors.initials: WF
authors.lastname: Huffman
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D029968:Escherichia coli Proteins; D054889:Fatty Acid Synthase, Type II; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D029968:Escherichia coli Proteins; D007093:Imidazoles; D010088:Oxidoreductases; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); C493924:fabI protein, E coli; D054889:Fatty Acid Synthase, Type II