The contribution of vitamin C to healing of experimental fractures.
The benefits of various minerals and vitamins on fracture healing have been demonstrated in animal models. Vitamin C is an essential substance in fracture healing but has not been studied previously on an experimental basis. Sixteen rats were grouped randomly into control and vitamin C-supplemented groups. The right tibias of all rats were fractured by digital manipulation. One group received single high dose of vitamin C intramuscularly. On the 5th, 10th, 15th, and 20th days, two rats from each group were killed and the tibias examined under light microscopy. It was seen that the vitamin C-supplemented group went through the stages of fracture healing faster compared with the control group.
Yilmaz
C
C
Department of Orthopaedics and Traumatology, University of Ankara Medical School, Turkey. cyilmaz@doctor.com
Erdemli
E
E
Selek
H
H
Kinik
H
H
Arikan
M
M
Erdemli
B
B
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage*; D017102:Fracture Healing / Q000187:drug effects*; D050723:Fractures, Bone / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D001205:Ascorbic Acid