title: Synthesis and antiproliferative activity of epoxy and bromo compounds derived from estrone.
abstract: Based on biological properties of epoxyquinols from natural sources, bromo and epoxyquinols derived from estrone were synthesized and screened against Fem-X, HeLa and K(562) cell lines. Evidence was found that the bromine atom and the epoxy moiety significantly increase the antiproliferative activity within the series.
authors.affiliation: Faculty of Chemistry, University of Belgrade, Studentski trg 16, PO Box 158, YU-11001, Belgrade, Yugoslavia.
authors.forename: D R
authors.initials: DR
authors.lastname: Milic
authors.forename: T
authors.initials: T
authors.lastname: Kop
authors.forename: Z
authors.initials: Z
authors.lastname: Juranic
authors.forename: M J
authors.initials: MJ
authors.lastname: Gasic
authors.forename: B A
authors.initials: BA
authors.lastname: Solaja
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001966:Bromine / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004852:Epoxy Compounds / Q000737:chemistry*; D004970:Estrone / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D004970:Estrone; D001966:Bromine