title: Wnt signalling: antagonistic Dickkopfs.
abstract: Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt--Frizzled--LRP5/6 receptor complexes, thus blocking the canonical Wnt--beta-catenin pathway.
authors.affiliation: Wellcome/CRC Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Zorn
mesh_terms: D000818:Animals; D051157:Frizzled Receptors; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D026502:LDL-Receptor Related Proteins; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D011485:Protein Binding; D011506:Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011973:Receptors, LDL / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: C501126:DKK1 protein, human; D051157:Frizzled Receptors; D036341:Intercellular Signaling Peptides and Proteins; D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D011506:Proteins; D011518:Proto-Oncogene Proteins; D011973:Receptors, LDL; D051153:Wnt Proteins; D029961:Zebrafish Proteins; C501128:dkk1b protein, zebrafish