title: Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues.
abstract: A discussion of the solid-phase synthesis of ornithine derived sulfonamide hydroxamic acids is illustrated. These analogues are shown to be potent, non-peptide inhibitors of procollagen C-proteinase (PCP).
authors.affiliation: Roche Bioscience, Inflammatory Diseases Unit, 3401 Hillview Ave, Palo Alto, CA 94304, USA. sharon.dankwardt@roche.com
authors.forename: S M
authors.initials: SM
authors.lastname: Dankwardt
authors.forename: R L
authors.initials: RL
authors.lastname: Martin
authors.forename: C S
authors.initials: CS
authors.lastname: Chan
authors.forename: H E
authors.initials: HE
authors.lastname: Van Wart
authors.forename: K A
authors.initials: KA
authors.lastname: Walker
authors.forename: N G
authors.initials: NG
authors.lastname: Delaet
authors.forename: L A
authors.initials: LA
authors.lastname: Robinson
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009952:Ornithine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D019485:Bone Morphogenetic Proteins; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D013449:Sulfonamides; D009952:Ornithine; D008666:Metalloendopeptidases; D055395:Bone Morphogenetic Protein 1