Inhibition of the glutamate transporter by L-trans-PDC in the nucleus accumbens prevents the locomotor response to amphetamine.
Infusion in the nucleus accumbens of the glutamate uptake inhibitor L-trans-PDC prevented the amphetamine-induced locomotor response. Since L-trans-PDC has been shown to block the amphetamine-induced increase in glutamate but not in DA release, our result indicates that the glutamate transporter is an obligatory target for the activating properties of amphetamine.
David
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HN
Université de Caen, UMR CNRS 6551, Centre CYCERON, Boulevard Henri Becquerel, BP 5229, 14074 Caen Cedex, France.
Thévenoux
A
A
Abraini
J H
JH
D027322:Amino Acid Transport System X-AG / Q000037:antagonists & inhibitors*; D000661:Amphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D027322:Amino Acid Transport System X-AG; D000697:Central Nervous System Stimulants; D003998:Dicarboxylic Acids; D014179:Neurotransmitter Uptake Inhibitors; D011759:Pyrrolidines; C083486:pyrrolidine-2,4-dicarboxylic acid; D000661:Amphetamine