title: Failure of grommet insertion in post-irradiation otitis media with effusion.
abstract: Nasopharyngeal carcinoma (NPC) survivors with post-irradiation otitis media with effusion (OME; 100 ears) were divided into 2 groups. One group underwent grommet insertion, and the other group was treated by repeated myringotomies plus aspiration to evaluate the outcome of the OME. Computed tomography, magnetic resonance imaging, audiometry, and local checks of the ear, nose, and nasopharyngeal fields were performed to evaluate the sinus and middle ear conditions over a long-term (more than 10 years) follow-up period. The results in these NPC survivors with OME indicated that the prevalence of middle ear complications in the myringotomized group (33%) was less than that in the grommeted group (90%). Grommets alone cannot eradicate inflammation outside the middle ear cavity, but rather, they can aggravate it by superinfection. We therefore recommend that controlling the radiation-induced inflammation in areas such as the ears, nose, sinuses, and nasopharynx is most important. In conclusion, post-irradiation OME should be treated in a different way from conventional OME. Restated, grommet insertion is contraindicated in post-irradiation OME.
authors.affiliation: Department of Otolaryngology, National Taiwan University Hospital, Taipei.
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: Y H
authors.initials: YH
authors.lastname: Young
authors.forename: W C
authors.initials: WC
authors.lastname: Hsu
authors.forename: M M
authors.initials: MM
authors.lastname: Hsu
mesh_terms: D000328:Adult; D000368:Aged; D001299:Audiometry; D001844:Bone Conduction; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008876:Middle Ear Ventilation; D009225:Myringoplasty; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D010034:Otitis Media with Effusion / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D011832:Radiation Injuries / Q000175:diagnosis; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure