title: What are the priorities for managing cholesterol effectively?
abstract: Many studies have confirmed the risk of coronary artery disease associated with elevated levels of low-density lipoprotein cholesterol (LDL-C). The precise role of other lipids, however, is still under investigation. The relation between elevated levels of triglycerides and low levels of high-density lipoprotein cholesterol (HDL-C) is complex, and the results of clinical trials evaluating interventions to lower triglycerides or increase levels of HDL-C have been equivocal. Based on the data currently available, LDL-C remains the primary target for treatment. Ongoing clinical trials will help to answer the question of how low we should set our goals for lowering cholesterol in patients at risk.
authors.affiliation: Division of Medicine, Atlanta Veterans Administration Medical Center, Division of Arteriosclerosis and Lipid Metabolism, Emory University, Atlanta, Georgia 30003, USA. W.Virgil.Brown@med.va.gov
authors.forename: W V
authors.initials: WV
authors.lastname: Brown
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000517:prevention & control*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides