New bioactive chalcones in propolis from El Salvador.
2',3'-Dihydroxy-4,4'-dimethoxychalcone (1) and 2',3',4-trihydroxy-4'-methoxy-chalcone, two new chalcones, were isolated from propolis from El Salvador. The compounds showed significant antibacterial and antifungal activity and moderate toxicity to Artemia salina nauplii.
Popova
M
M
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia.
Bankova
V
V
Spassov
S
S
Tsvetkova
I
I
Naydenski
C
C
Silva
M V
MV
Tsartsarova
M
M
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001156:Artemia; D002109:Caffeic Acids / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D002599:Chalcone / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002855:Chromatography, Thin Layer; D004544:El Salvador; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011427:Propiophenones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D011429:Propolis / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D002109:Caffeic Acids; D011427:Propiophenones; D002599:Chalcone; D011429:Propolis; C040048:caffeic acid