To be or not to be: a question of B-Raf?
A recent study has identified the B-Raf gene as essential for the survival of explanted sensory and motor neurons in culture in response to neurotrophic factors. This finding sheds new light on the control of neuronal development and poses new questions with regard to Raf-isozyme-specific functions.
Kolch
W
W
Institute for Biomedical and Life Sciences, University of Glasgow, Glasgow, UK. wkolch@beatson.gla.ac.uk
D000818:Animals; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured / Q000201:enzymology; D029968:Escherichia coli Proteins; D006801:Humans; D026901:Membrane Transport Proteins / Q000096:biosynthesis* / Q000235:genetics; D009046:Motor Neurons / Q000166:cytology / Q000201:enzymology*; D009475:Neurons, Afferent / Q000166:cytology / Q000201:enzymology*; D019908:Proto-Oncogene Proteins c-raf / Q000502:physiology*
D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; C062064:raffinose permease, E coli; D019908:Proto-Oncogene Proteins c-raf