Enzymatic synthesis of aza-l-tyrosines.
Tyrosine phenol-lyase from Citrobacter freundii synthesizes 2-aza-L-tyrosine and 3-aza-L-tyrosine from 3-hydroxypyridine and 2-hydroxypyridine, respectively, and ammonium pyruvate.
Watkins
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EB
Department of Medicinal Chemistry, University of Mississippi, University, MS 38677, USA.
Phillips
R S
RS
D000409:Alanine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D016971:Citrobacter freundii / Q000201:enzymology*; D011725:Pyridines / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry; D014447:Tyrosine Phenol-Lyase / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D011725:Pyridines; D011728:Pyridones; C011870:beta-(5-hydroxy-2-pyridyl)alanine; C023500:3-hydroxypyridine; C017679:2-hydroxypyridine; D014447:Tyrosine Phenol-Lyase; D000409:Alanine