[Optimization of indirect electrochemical detoxication in the treatment of different endogenous intoxications and multiple organ failure syndrome in resuscitation practice].
The authors have made a statistical analysis of clinical groups of patients in the units of resuscitation and intensive therapy of a general profile and of the archive materials of a laboratory of extracorporeal hemocorrection. The ultraviolet and laser photomodification of autoblood, hemosorption, plasmapheresis, ultra- and hemofiltration were used in the complex treatment of these patients. In the experimental group there were 190 patients on whom 333 operations of extracorporeal hemocorrection were made with using indirect electrochemical detoxication (IECD). In the control group there were 527 patients on whom 1048 analogous operations were made without IECD. The statistical processing of the results obtained has shown that IECD method does not have immediate detoxicating properties in relation to middle mass molecules and fails to substantially influence the processes of lipid peroxidation; sodium hypochlorite did not have a deteriorating effect on the clinical-laboratory status of patients with severe organic disorders. IECD was shown to potentiate the elimination potencies of hemosorption, plasmapheresis, ultra- and hemofiltration which resulted in 2.7 times less lethality. The mean bed-day was 2.8 days shorter, the bed-day in the resuscitation unit--1.2 days shorter.
Romanchishen
A F
AF
Zotikov
A G
AG
Chalenko
V V
VV
Pastukhova
N K
NK
Shakh
B N
BN
Lapshin
V N
VN
D018806:APACHE; D003422:Critical Care; D003627:Data Interpretation, Statistical; D004563:Electrochemistry; D006440:Hemofiltration; D006801:Humans; D007902:Length of Stay; D015227:Lipid Peroxidation; D009102:Multiple Organ Failure / Q000097:blood / Q000628:therapy*; D010956:Plasmapheresis; D012720:Severity of Illness Index; D016060:Sorption Detoxification; D013997:Time Factors; D014462:Ultrafiltration
Optimizatsiia nepriamoĭ élektrokhimicheskoĭ detoksikatsii pri lechenii razlichnykh éndogennykh intoksikatsiĭ i sindroma poliorgannoĭ nedostatochnosti v reanimatologicheskoĭ praktike.