title: Strategy to decrease the risk of adverse effects of fragrance ingredients in cosmetic products.
abstract: In spite of extensive self-regulation of the fragrance industry, fragrance ingredients are still major causes of allergic contact dermatitis. There are indications that the problem is increasing in some countries, and that many nonregulated compounds are involved in the development of allergies. The use of essential oils in fragrance compounds might add both allergenic and carcinogenic compounds to a product and the exact composition of such ingredients is difficult to control. Herein, we propose a simple strategy to decrease the risk of adverse effects of fragrance ingredients in cosmetic products. This strategy consists of four major steps: (1) limit the concentration of fragrance compound in the products, (2) follow legislation and guidelines, (3) limit the concentration of a number of well-known sensitizing fragrance chemicals, and (4) limit the concentration of essential oils and materials with unknown composition. The strategy is discussed as an alternative to animal testing and in relation to other more resource-demanding approaches to the same problem.
authors.affiliation: TJ Toxikologikonsult, Krysshammarvägen, Solna.
authors.forename: T
authors.initials: T
authors.lastname: Jansson
authors.forename: M
authors.initials: M
authors.lastname: Lodén
mesh_terms: D000826:Animal Testing Alternatives; D003358:Cosmetics / Q000009:adverse effects / Q000592:standards*; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000517:prevention & control*; D017408:Guidelines as Topic; D006801:Humans; D007221:Industry / Q000592:standards*; D007391:International Cooperation; D010476:Perfume / Q000009:adverse effects; D010938:Plant Oils / Q000009:adverse effects
chemical_list: D003358:Cosmetics; D010476:Perfume; D010938:Plant Oils