Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration.
Using a previously developed method (Ambrus, et al., 1991), we found that pentoxifylline and thalidomide potentiate each others antiangiogenic effect induced by human malignant melanoma cells in the cornea of Macaca arctoides monkeys.
Ambrus
J L
JL
Department of Internal Medicine, State University of NY at Buffalo Medical School-Kaleida Health Systems, 14203, USA.
Toumbis
C A
CA
Karakousis
C P
CP
Kulaylat
M
M
Akhter
S
S
Plavsic
L
L
D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002478:Cells, Cultured; D003315:Cornea / Q000187:drug effects*; D016510:Corneal Neovascularization / Q000188:drug therapy* / Q000473:pathology; D004338:Drug Combinations; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D015603:Keratinocytes; D008251:Macaca; D008268:Macular Degeneration / Q000188:drug therapy; D008545:Melanoma / Q000473:pathology*; D010431:Pentoxifylline / Q000494:pharmacology*; D013792:Thalidomide / Q000494:pharmacology*
D020533:Angiogenesis Inhibitors; D004338:Drug Combinations; D004791:Enzyme Inhibitors; D013792:Thalidomide; D010431:Pentoxifylline