title: Serial changes of cardiac troponin-I in acute myoischemia induced by exercise treadmill test.
abstract: Cardiac troponin-I (cTn-I) is a sensitive and specific marker for the diagnosis of acute myocardial infarction (AMI). However, elevation of serum cTn-I has been observed in some unstable angina patients who have a worse prognosis than those with normal serum cTn-I levels. It is unknown whether serum cTn-I can elevate in stable angina patients with acute ischemic burden. Therefore, the purpose of this study was to determine a serial change of cTn-I in patients with acute ischemia induced by a treadmill exercise test. Thirty-five patients suspected of having coronary artery disease and five healthy medical students were enrolled into this study. Every patient received a treadmill exercise test. Cardiac troponin-I was measured by fluorescent immunoassay before the treadmill test and at 5 minutes, 1 hour, 3 hours, and 6 hours after the treadmill test. Patients with cTn-I levels of less than 0.5 ng/ml were considered normal, and those with cTn-I levels of greater than 2.0 ng/ml was considered to have AMI. The exercise test was positive in 19 of the 35 patients and negative in 16 of the 35 patients and 5 medical students. Among the 19 patients with positive treadmill exercise test, the cTn-I concentrations were abnormally increased in 7/19 (37%) patients (mean: 1.1 +/- 0.4 ng/ml; range: 0.5 to 2.0 ng/ml). One of the 16 patients with negative treadmill test showed an increase of serum cTn-I. Normal cTn-I levels were found in the other 15 patients and the 5 medical students. In conclusion, serum cTn-I levels were found to increase to some extent in one third of stable angina patients who have an acute ischemic episode induced by treadmill exercise test.
authors.affiliation: Department of Internal Medicine, Kaohsiung Medical University Hospital, No. 100, Shih-Chuang 1st Rd., Kaohsiung, 80708, Taiwan.
authors.forename: K T
authors.initials: KT
authors.lastname: Lee
authors.forename: W T
authors.initials: WT
authors.lastname: Lai
authors.forename: W R
authors.initials: WR
authors.lastname: Chen
authors.forename: S H
authors.initials: SH
authors.lastname: Sheu
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood*; D009206:Myocardium / Q000737:chemistry*; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I