title: Effects of abstinence from alcohol on the broad phospholipid signal in human brain: an in vivo 31P magnetic resonance spectroscopy study.
abstract: BACKGROUND
  In vivo phosphorus magnetic resonance spectroscopy (31P MRS) at a magnetic field strength of 1.5 T allows measurement of fairly mobile membrane phospholipids in the human brain. We previously showed that subjects who are heavy drinkers had a smaller signal and a shorter transverse relaxation time (T2) of white matter phospholipids than light drinkers, which suggested lower concentrations and molecular mobility of phospholipids in heavy drinkers. The purpose of the present study was to measure if such chronic alcohol-induced white matter tissue changes are persistent in long-term abstinent alcoholics.
  
  
  METHODS
  Fourteen abstinent alcoholics (mean age 45 years, seven men and seven women) were studied by localized 31P MRS in the centrum semiovale and were compared with 13 male, alcohol-dependent, heavy drinkers and 23 nondependent light drinkers (17 men, 6 women) of similar age. Methods for measurements of the broad membrane phospholipid signal and its relaxation time were described previously.
  
  
  RESULTS
  Phospholipid concentrations and relaxation times in alcoholics abstinent for an average of 31 months were not significantly different from those measured in light drinkers. The contribution of fast and slowly relaxing signal components to the broad phospholipid signal, however, was still different in abstinent alcoholics compared with light drinkers. No effects of sex or of family history of alcoholism were noted on any of our spectroscopic measures within the light-drinking or abstinent groups.
  
  
  CONCLUSIONS
  Most of our results suggest at least partial recovery of chronic alcohol-induced white matter phospholipid damage with long-term abstinence. They offer myelination changes and/or dendritic rearborization as a possible mechanism for the commonly observed white matter volume gain with prolonged abstinence. But the results also suggest a persistent abnormality in the nature and/or physical properties of white matter phospholipids in long-term abstinent alcoholics.
authors.affiliation: MR Unit DVA Medical Center, Department of Radiology, University of California San Francisco, 94121, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Estilaei
authors.forename: G B
authors.initials: GB
authors.lastname: Matson
authors.forename: G S
authors.initials: GS
authors.lastname: Payne
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: G
authors.initials: G
authors.lastname: Fein
authors.forename: D J
authors.initials: DJ
authors.lastname: Meyerhoff
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000378:metabolism* / Q000628:therapy; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008563:Membrane Lipids / Q000032:analysis / Q000378:metabolism; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D010761:Phosphorus Radioisotopes
chemical_list: D008563:Membrane Lipids; D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D000431:Ethanol