Diagnosis of cerebellar cortical degeneration in a Scottish terrier using magnetic resonance imaging.
Primary cerebellar cortical degeneration (CCD), also termed abiotrophy, is the spontaneous premature degeneration of fully differentiated neurological tissue. Cerebellar hypoplasia shares many morphological features with primary CCD, both conditions being characterised by decreased cerebellar size, with reduced numbers of Purkinje and granular cells. CCD has been identified in many canine breeds. This is the first report of the syndrome in a Scottish terrier. The patient presented with mild, gradually progressive ataxia. Survey radiographs of the cervical spine and cerebrospinal fluid (CSF) analysis were normal. CSF distemper and Toxoplasma titres were negative. A diagnosis of cerebellar atrophy was made based on magnetic resonance imaging. The progressive clinical signs suggested cerebellar degeneration rather than hypoplasia. On necropsy, the cerebellum showed macroscopic and microscopic changes consistent with primary CCD.
van der Merwe
L L
LL
Department of Companion Animal Medicine, Faculty of Veterinary Science, University of Pretoria, Republic of South Africa.
Lane
E
E
D000818:Animals; D002525:Cerebellar Cortex / Q000473:pathology; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D013132:Spinocerebellar Degenerations / Q000175:diagnosis / Q000662:veterinary*