title: Anaphylaxis to the 23-valent pneumococcal vaccine in child: a case-control study based on immediate responses in skin tests and specific IgE determination.
abstract: Injections of the 23-valent pneumococcal vaccine are usually well tolerated. Skin tests (prick and intradermal) and a self-made RAST with pneumococcal vaccine and phenol were performed in a child reporting a severe anaphylactic reaction induced by a 23-valent pneumococcal vaccine, and in ten control children, including one child with a well-tolerated vaccination, and nine non-vaccinated children. Skin tests and RAST with the vaccine were positive in the child reporting anaphylaxis, and negative in nine of the control children. Intradermal test with the vaccine was slightly positive in a non-vaccinated child with negative RAST. Skin tests and RAST with phenol were negative in all the children. These results suggest that immediate responses in skin tests and specific IgE determination have a good diagnostic value in children reporting severe reactions suggestive of IgE-dependent hypersensitivity to pneumococcal vaccine.
authors.affiliation: Department of Medicine, Paris VI University, Paediatric Pulmonology & Allergy Service, Sick Children Hospital, 149 rue de Sèvres, 75015, Paris, France. pneumo.allergo@nck.ap-hop-paris.fr
authors.forename: C
authors.initials: C
authors.lastname: Ponvert
authors.forename: D
authors.initials: D
authors.lastname: Ardelean-Jaby
authors.forename: A M
authors.initials: AM
authors.lastname: Colin-Gorski
authors.forename: B
authors.initials: B
authors.lastname: Soufflet
authors.forename: C
authors.initials: C
authors.lastname: Hamberger
authors.forename: J
authors.initials: J
authors.lastname: de Blic
authors.forename: P
authors.initials: P
authors.lastname: Scheinmann
mesh_terms: D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology; D016667:Bacterial Capsules / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D007428:Intradermal Tests; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D022242:Pneumococcal Vaccines / Q000009:adverse effects* / Q000276:immunology; D011852:Radioallergosorbent Test; D012778:Short Bowel Syndrome / Q000150:complications; D012882:Skin Tests; D014640:Vancomycin / Q000009:adverse effects
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022242:Pneumococcal Vaccines; D007073:Immunoglobulin E; D014640:Vancomycin