title: Adjunctive therapies in the cath lab. Combination of tirofiban and alteplase in acute myocardial infarction.
abstract: Primary angioplasty results in higher reperfusion rates than fibrinolysis in patients with acute myocardial infarction (MI). Two recent trials have shown improved rates of reperfusion when a reduced-dose thrombolytic is combined with the platelet glycoprotein IIb/IIIa receptor inhibitor abciximab. We present a case report of acute MI successfully treated with a combination of tirofiban and half-dose alteplase and eventual percutaneous coronary intervention.
authors.affiliation: Department of Medicine, MCP Hahnemann University, Philadelphia, Pennsylvania, USA.
authors.forename: H
authors.initials: H
authors.lastname: Arjomand
authors.forename: A B
authors.initials: AB
authors.lastname: Sokil
authors.forename: R
authors.initials: R
authors.lastname: Arjmand
authors.forename: H A
authors.initials: HA
authors.lastname: Fischer
authors.forename: N M
authors.initials: NM
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000800:Angioplasty, Balloon; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D000077466:Tirofiban; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D014443:Tyrosine; D010959:Tissue Plasminogen Activator; D000077466:Tirofiban