title: A simple synthesis of [11C]carfentanil using an extraction disk instead of HPLC.
abstract: [11C]Carfentanil was prepared without the need for purification by HPLC. The tetrabutylammonium salt of the precursor carboxylate was reacted with [11C]methyl triflate in DMSO. The resulting [11C]carfentanil was trapped on an Empore extraction disk and washed to remove precursor and most radioactive contaminants. The product was eluted by a small volume of ethanol, mixed with water and passed through a small column containing fibrous anion exchanger to remove remaining radioactive contaminants.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical Center, 3480 Kresge 3, Box 0552, Ann Arbor, MI 48109-0552, , USA. doogie@umich.edu
authors.forename: D M
authors.initials: DM
authors.lastname: Jewett
mesh_terms: D000701:Analgesics, Opioid / Q000138:chemical synthesis*; D002621:Chemistry / Q000295:instrumentation; D002851:Chromatography, High Pressure Liquid; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D000701:Analgesics, Opioid; C017114:carfentanil; D005283:Fentanyl