title: [Effectiveness of bio-regulators in the treatment of diabetic retinopathy].
abstract: Treatment of diabetic retinopathy remains a most important problem of modern ophthalmology. Bioregulatory therapy has been widely used in recent years as one of promising trends in clinical medicine. The purpose of this study was to evaluate the efficiency of peptide bioregulators in combined treatment of diabetic retinopathy. A total of 104 patients were administered bioregulatory therapy (retinal preparation retinalamine, epiphysis preparation epithalamine, cerebral cortex preparation cortexine,) and 42 patients were controls. Peptide bioregulators in 90% cases promoted improvement of vision acuity, improved the ophthalmoscopic picture of the fundus oculi (resolution of hemorrhages, plasmorrhages, decreased macular edema) and in all cases improved the functional activity of the retina and retinal bloodflow. No negative changes in the clinical picture were observed after peptide bioregulators in any of the cases. Peptide bioregulators normalized carbohydrate metabolism (sugar level and glycosylated hemoglobin in the blood), phagocytosis, and improved the subjective well-being of patients. Hence, the data indicate a pathogenetic effect of this therapeutic method and its good prospects in ophthalmology.
authors.forename: S V
authors.initials: SV
authors.lastname: Trofimova
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D003930:Diabetic Retinopathy / Q000097:blood / Q000188:drug therapy*; D006706:Homeostasis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D009887:Ophthalmoscopy; D010455:Peptides / Q000627:therapeutic use*; D010587:Phagocytosis; D010870:Pineal Gland / Q000737:chemistry; D012160:Retina / Q000737:chemistry; D014792:Visual Acuity
chemical_list: D000276:Adjuvants, Immunologic; D001786:Blood Glucose; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C027437:epithalamin; C056590:cortexin
vernacular_title: Effektivnost' bioreguliatorov pri lechenii diabeticheskoĭ retinopatii.