LY354740 attenuates the expression of long-term behavioral sensitization induced by a single session of foot shocks.
Exposure of rats to a single session of foot shocks sensitizes behavioral responses to novel stimuli. There is evidence that metabotropic glutamate (mGlu) receptors play a role in sensitization processes. In the present study, we investigated the role of mGlu(2/3) receptors in the long-term (14 days) increase in defensive withdrawal behavior after a single session of foot shocks. Exposure to foot shocks increased defensive withdrawal behavior. The mGlu(2/3) receptor agonist LY354740 ((1S,2S,5R,6S)-(+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 0.1 mg/kg, i.p.) normalized the increased latency and the decreased time in the light of the preshocked rats. We conclude that activation of mGlu(2/3) receptors attenuates the foot shock-induced expression of behavioral sensitization.
Bruijnzeel
A W
AW
Division of Pharmacology and Anatomy, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, P.O. Box 85060, 3508 AB, Utrecht, The Netherlands. A.W.Bruijnzeel@med.uu.nl
Stam
R
R
Wiegant
V M
VM
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D005528:Foot; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001643:Bridged Bicyclo Compounds; D018690:Excitatory Amino Acid Agonists; C104753:eglumetad