title: Approaches to enhancing the sensitivity of capillary electrophoresis methods for the determination of inorganic and small organic anions.
abstract: One of the major problems facing the development of capillary electrophoresis (CE) is the relatively high limits of detection when compared to traditional high-performance liquid chromatographic (HPLC) methods. While the use of an alternative detector can offer better sensitivity, a more universal approach is sample preconcentration. Numerous on-line methods have been developed to improve the sensitivity of CE, and are based on electrophoretic principles, chromatographic principles, or a combination of both. This review will discuss all forms of on-line preconcentration methods for CE, with emphasis given to those that have shown particular merit when applied to inorganic and small organic anions.
authors.affiliation: Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart.
authors.forename: M C
authors.initials: MC
authors.lastname: Breadmore
authors.forename: P R
authors.initials: PR
authors.lastname: Haddad
mesh_terms: D000838:Anions / Q000032:analysis*; D002845:Chromatography / Q000379:methods; D002852:Chromatography, Ion Exchange; D002853:Chromatography, Liquid; D004586:Electrophoresis; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D005544:Forecasting; D006863:Hydrogen-Ion Concentration; D007287:Inorganic Chemicals / Q000032:analysis; D009930:Organic Chemicals / Q000032:analysis; D012680:Sensitivity and Specificity
chemical_list: D000838:Anions; D007287:Inorganic Chemicals; D009930:Organic Chemicals