Studies on metal phthalocyanine as a dual functional mimic enzyme.
Four phthalocyanines (iron tetracarboxylphthalocyanine, copper tetracarboxylphthalocyanine, manganese tetracarboxylphthalocyanine, cobalt tetracarboxylphthalocyanine) were used as dual functional mimic enzymes of superoxide dismutase (SOD) and catalase (CAT). The first function, eliminating O2-, was proved by using riboflavine-methionine photoreduction method in the concentration range of 10(-5) to 10(-6) mol/L. The second function, clearing out H2O2, was demonstrated by means of spectrophotometry with the decomposing percentage being increased with the increase of the concentration of the imitating compounds. Measurements of metal phthalocyanines, SOD and CAT by the liver homogenate technique of mice showed that they had obvious action of decreasing the lipid peroxidation.
Feng
Q
Q
Department of Chemistry, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
Liu
L
L
He
Y
Y
Wang
H
H
Wu
M
M
Mei
F
F
D000818:Animals; D002374:Catalase / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology; D054833:Isoindoles; D015227:Lipid Peroxidation / Q000187:drug effects; D008345:Manganese / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D013482:Superoxide Dismutase / Q000494:pharmacology
D002614:Chelating Agents; D007211:Indoles; D054833:Isoindoles; D008670:Metals; D008345:Manganese; D003300:Copper; D007501:Iron; D002374:Catalase; D013482:Superoxide Dismutase; C013647:phthalocyanine