De novo initiation of viral RNA-dependent RNA synthesis.
RNA viruses use several initiation strategies to ensure that their RNAs are synthesized in appropriate amounts, have correct termini, and can be translated efficiently. Many viruses with genomes of single-stranded positive-, negative-, and double-stranded RNA initiate RNA synthesis by a de novo (primer-independent) mechanism. This review summarizes biochemical features and variations of de novo initiation in viral RNA replication.
Kao
C C
CC
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA. ckao@bio.indiana.edu
Singh
P
P
Ecker
D J
DJ
D018067:Flaviviridae / Q000235:genetics* / Q000502:physiology; D005544:Forecasting; D006801:Humans; D012367:RNA, Viral / Q000235:genetics*; D014779:Virus Replication
D012367:RNA, Viral