Asymmetrical activation of human visual cortex demonstrated by functional MRI with monocular stimulation.
We have demonstrated asymmetric activation patterns in the visual cortices of normal humans who have undergone functional MRI with monocular photic stimulation. The contralateral hemisphere is activated more strongly and to a greater spatial extent than the ipsilateral hemisphere when either eye is stimulated. This asymmetry can be explained by nasotemporal asymmetries which have been described in anatomical studies of the visual system in primates and humans. In part, the representation of the monocular crescent of the temporal hemifield of either eye, which exists only in the crossed projection, may explain this. In addition, within the binocular field, there is a biased crossed projection of nasal retinal ganglion cells which drive the contralateral ocular dominance columns in V1. Finally, the blind spot representation in the ipsilateral visual cortex may also contribute to the observed asymmetries. Our study may in effect provide a functional correlate of the anatomical asymmetries that have been observed in humans and animals.
Toosy
A T
AT
NMR Research Unit, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.
Werring
D J
DJ
Plant
G T
GT
Bullmore
E T
ET
Miller
D H
DH
Thompson
A J
AJ
D000328:Adult; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D012016:Reference Values; D013997:Time Factors; D015349:Vision, Monocular / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*