Augmentation of the pharmacological action of corydalis tuber by saussurea root in isolated mouse ileum.
To understand the meaning of blending crude drugs in Chinese medicinal prescriptions, the influence of Saussurea root on the pharmacological action of Corydalis tuber was examined. Saussurea root increased the depression of acetylcholine-induced contraction caused by the hot water extract solution of Corydalis tuber in mouse ileum at low dosage, which showed no direct influence on acetylcholine. Dehydrocostuslactone in Saussurea root was characterized as the component having increasing activity and the relationship between the concentration of acetylcholine and the variation in the contraction depressed by Corydalis tuber alone or a mixture of the Corydalis tuber and dehydrocostuslactone was investigated for clarification of the mode of action.
Kobayashi
K
K
Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan.
Motohara
T
T
Honma
A
A
Takahashi
R
R
Aihara
M
M
Sudo
T
T
Yoshizaki
F
F
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003687:Dehydroepiandrosterone / Q000302:isolation & purification / Q000494:pharmacology; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D003687:Dehydroepiandrosterone; D000109:Acetylcholine