Disease model: hyperinsulinemia and insulin resistance. Part B--polygenic and other animal models.
Deficiency of leptin or its receptor produces hyperinsulinemia with marked obesity. Paradoxically, severe insulin resistance also accompanies lipodystrophy. Animal models of these contrasting conditions have enabled us to observe the profound and complicated aspects of the underlying pathologies. In addition, conventional polygenic rodents with known genetic backgrounds, such as the spontaneously hypertensive rat and the Goto-Kakisaki rat, have also been used to investigate these abnormalities.
Sone
H
H
Dept. of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, (305-8575), Tsukuba city, Japan.
Takahashi
A
A
Iida
K
K
Yamada
N
N
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D006946:Hyperinsulinism / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics*; D020738:Leptin / Q000235:genetics; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis; D051379:Mice; D020412:Multifactorial Inheritance / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D051381:Rats; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin
D002352:Carrier Proteins; D020738:Leptin; D008055:Lipids; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin