The biological application of small animal PET imaging.
The short history of small animal PET is reviewed in the context of its application in the laboratory. Early work has demonstrated a role for the technique in both drug development and in the in vivo monitoring of neuroreceptor function with time. As spatial resolution approaches 1 mm, challenges in quantification remain. However, the ability to carry out animal PET studies that are analogous to human PET will form an important bridge between laboratory and clinical sciences.
Myers
R
R
MRC Cyclotron Unit, Hammersmith Hospital, Ducane Road, London, W12 0NN, UK. ralph.myers@csc.mrc.ac.uk
D000818:Animals; D015195:Drug Design; D015870:Gene Expression; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000295:instrumentation