title: Chronic loss of ovarian function decreases transport of leptin into mouse brain.
abstract: Loss of ovarian function, such as occurs with menopause in human beings and ovariectomy in rodents, results in weight gain. Using multiple-time regression analysis, a sensitive technique for quantifying blood-to-brain transport of peptides and polypeptides, we found that mice ovariectomized for at least 5 weeks had markedly reduced entry of the satiety factor leptin into brain. The rate of entry of leptin into brain remained reduced half a year later. The results suggest that the weight gain resulting from loss of ovarian function could be explained by decreased transport of leptin into the brain.
authors.affiliation: VA Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112-1262, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Kastin
authors.forename: V
authors.initials: V
authors.lastname: Akerstrom
authors.forename: L M
authors.initials: LM
authors.lastname: Maness
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D007457:Iodine Radioisotopes; D020738:Leptin / Q000378:metabolism*; D051379:Mice; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D015430:Weight Gain / Q000502:physiology
chemical_list: D007457:Iodine Radioisotopes; D020738:Leptin