Bronchiolitis obliterans organizing pneumonia (BOOP) with suspected liver graft-versus-host disease after allogeneic bone marrow transplantation.
We report on a patient with chronic myelogenous leukemia who developed bronchiolitis obliterans organizing pneumonia (BOOP) after allogeneic bone marrow transplantation (BMT). A 19-year-old Japanese male complained of dry cough and dyspnea 7 months after BMT. The chest X-ray and computed tomography revealed patchy infiltrates bilaterally. Lung function test, lung biopsy and bronchoalveolar lavage were consistent with the diagnosis of BOOP. The patient also suffered from suspected graft-versus-host disease (GVHD) of the liver, after discontinuation of cyclosporine. Furthermore, prednisolone proved effective against the BOOP and the liver dysfunction. These findings indicate that BOOP is a possible pulmonary manifestation of chronic GVHD, and that immunological mechanisms may have effected the onset of BOOP after BMT in this case.
Kanamori
H
H
First Department of Internal Medicine, Yokohama City, University School of Medicine, 3-9 Fukuura Kanazawa-ku, Yokohama 236-0004, Japan. heiwak@med.yokohama-cu.ac.jp
Mishima
A
A
Tanaka
M
M
Yamaji
S
S
Fujisawa
S
S
Koharazawa
H
H
Nishikawa
M
M
Matsuzaki
M
M
Mohri
H
H
Ishigatsubo
Y
Y
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D018549:Cryptogenic Organizing Pneumonia / Q000209:etiology*; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D008297:Male; D014184:Transplantation, Homologous