Procedure to evaluate the stability during processing and storage of a medicated premix and medicated farm feed: erythromycin thiocyanate.
In this paper, a stability study of a medicated premix and medicated farm feed containing erythromycin thiocyanate was planned. No drug degradation was detected during the medicated farm feed processing. In the medicated premix stability study, significant drug degradation was detected only at 40 degrees C and 75% relative humidity. Because after 2 years of storage at 25 degrees C and 60% relative humidity no degradation of erythromycin thiocyanate was detected, this period of time is proposed as the premix shelf life. In the medicated farm feed stability study, drug degradation was detected under accelerated conditions, but it was not detected under long-term storage conditions for 3 months. Therefore, the proposed shelf life of the medicated farm feed is 3 months, as this is time enough to be consumed. The planned stability study-storage conditions, testing frequency, and proposed data evaluation-allowed an easy and reliable evaluation of veterinary medicine stability.
Bernabéu
J A
JA
Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.
Camacho
M A
MA
Gil-Alegre
M E
ME
Torres-Suárez
A I
AI
D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D004355:Drug Stability; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000032:analysis*; D005511:Food Handling / Q000379:methods; D013997:Time Factors
D000900:Anti-Bacterial Agents; D004917:Erythromycin; C025000:erythromycin thiocyanate