Exposure to ozone aggravates nasal allergy-like symptoms in guinea pigs.
The ability of O3 exposure to aggravate ovalbumin (OVA)-induced nasal allergy-like symptoms was studied in guinea pigs. Guinea pigs were exposed to filtered air or to 0.4 ppm O3 for 5 weeks. During the exposure, 1% OVA or saline was administered into the nasal cavities once a week. Sneezes and nasal secretions were measured for a 20-min period following OVA administration. The number of eosinophils infiltrating both nasal epithelium and subepithelium and titers of specific anti-OVA-IgG were measured 24 h after the last administration. Ozone increased OVA-induced sneezing and nasal secretion, as well as induced nasal hyper-responsiveness to physical stimuli. The number of eosinophils infiltrating the nasal subepithelium was increased by O3, and the titer of anti-OVA-IgG tended to increase in the O3-exposed animals. Thus, exposure to O3 aggravated nasal allergy-like symptoms by inducing nasal hyper-responsiveness, the infiltration of eosinophils, and by tending to increase the production of anti-OVA-IgG.
Iijima
M K
MK
Department of Medicine, Tsukuba University, 305-8575, Tsukuba, Japan.
Kobayashi
T
T
Kamada
H
H
Shimojo
N
N
D000281:Administration, Intranasal; D000818:Animals; D000918:Antibody Specificity; D004804:Eosinophils / Q000276:immunology; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D010126:Ozone / Q000009:adverse effects* / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology; D012912:Sneezing / Q000187:drug effects / Q000276:immunology
D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010126:Ozone; D010047:Ovalbumin