Corticosteroid therapy reversed progressive chronic granulomatous lung disease following deterioration on interferon-gamma treatment.
We describe a patient who suffered from chronic progressive granulomatous lung disease. He had no clinical or microbiological evidence of infection. After failure of treatment with interferon-gamma and trimethoprim-sulfamethoxazole, he responded dramatically to corticosteroids.
Halamish
A
A
Department of Pediatrics, Bikur Cholim General Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Klar
A
A
Shoseyov
D
D
Blinder
G
G
Hurvitz
H
H
D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002648:Child; D018450:Disease Progression; D004351:Drug Resistance; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008171:Lung Diseases / Q000151:congenital* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D007371:Interferon-gamma