title: Large-cell lymphoma. An unusual late relapse.
abstract: We report a case of a 40-year-old man with a stage 4, anaplastic, large-cell lymphoma. He had been diagnosed 13 years before as having a liposarcoma, at which point he was treated with combination chemotherapy, which included anthracycline. On review of the histopathology from 13 years before, the original diagnosis of liposarcoma was revised to that of an anaplastic large-cell lymphoma. A diagnosis of relapsed anaplastic large-cell lymphoma was made. A MUGA scan showed a reduced ejection fraction of 46%. Our patient responded initially to combination chemotherapy, which included anthracycline, without further reduction in his ejection fraction. This was followed by high-dose chemotherapy and peripheral blood stem-cell transplantation. Twenty months later he is well and remains in complete remission.
authors.affiliation: Department of Haematology, Addenbrookes Hospital, Cambridge, UK.
authors.forename: K M
authors.initials: KM
authors.lastname: Bowles
authors.forename: R
authors.initials: R
authors.lastname: Tooze
authors.forename: R E
authors.initials: RE
authors.lastname: Marcus
mesh_terms: D000328:Adult; D018943:Anthracyclines / Q000008:administration & dosage / Q000633:toxicity; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003951:Diagnostic Errors; D006331:Heart Diseases / Q000139:chemically induced; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D012008:Recurrence; D012074:Remission Induction; D013318:Stroke Volume
chemical_list: D018943:Anthracyclines; D017730:Ki-1 Antigen; D017493:Leukocyte Common Antigens