Cedarmycins A and B, new antimicrobial antibiotics from Streptomyces sp. TP-A0456.
Two novel butyrolactone antibiotics, cedarmycins A and B, were isolated from the cultured broth of the actinomycete Streptomyces sp. TP-A0456. The new compounds were purified by HP-20 resin, silica gel, ODS column chromatographies and preparative HPLC, consecutively. The structure of cedarmycin was determined by spectroscopic methods as an alpha,beta-unsaturated butyrolactone with a fatty acid side chain. These compounds showed antibiotic activity against Gram-positive and -negative bacteria and yeasts. Among the tested organisms, cedarmycins potently inhibited the growth of Candida glabrata IFO 0622 with the MIC of 0.4 microg/ml, comparable to that of amphotericin B.
Sasaki
T
T
Biotechnology Research Center, Toyama  Prefectural University, Kosugi, Japan.
Igarashi
Y
Y
Saito
N
N
Furumai
T
T
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005285:Fermentation; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000378:metabolism
D000900:Anti-Bacterial Agents; D007783:Lactones; C435069:cedarmycin A; C435070:cedarmycin B