title: Models of CNS radiation damage during space flight.
abstract: The primary structural and functional arrangement of the different cell types within the CNS are reviewed.  This was undertaken with a view to providing a better understanding of the complex interrelationships that may contribute to the pathogenesis of lesions in this tissue after exposure to ionizing radiation.  The spectrum of possible CNS radiation-induced syndromes are discussed although not all have an immediate relevance to exposure during space flight.  The specific characteristics of the lesions observed would appear to be dose related.  Very high doses may produce an acute CNS syndrome that can cause death.  Of the delayed lesions, selective coagulation necrosis of white matter and a later appearing vascular microangiopathy, have been reported in patients after cancer therapy doses.  Lower doses, perhaps very low doses, may produce a delayed generalised CNS atrophy; this effect and the probability of the induction of CNS tumors could potentially have the greatest significance for space flight.
authors.affiliation: CRC Normal Tissue Radiobiology Research Group, Research Institute (University of Oxford), U.K.
authors.forename: J W
authors.initials: JW
authors.lastname: Hopewell
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D002490:Central Nervous System / Q000098:blood supply / Q000166:cytology / Q000503:physiopathology / Q000528:radiation effects*; D002493:Central Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D003711:Demyelinating Diseases / Q000209:etiology / Q000503:physiopathology*; D004307:Dose-Response Relationship, Radiation; D009381:Neoplasms, Radiation-Induced; D011829:Radiation Dosage; D051381:Rats; D013026:Space Flight; D013116:Spinal Cord / Q000503:physiopathology / Q000528:radiation effects; D013552:Swine