[Hepatoprotective effect of lipophen--a novel natural combined phospholipid preparation].
Studied in vitro, lipophen (in contrast to essentiale) did not separate the oxidation and phosphorylation processes in intact mitochondria. The antioxidant effect of lipophen with respect to enzymatic or ascorbate-dependent lipid peroxidation in intact microsomes from rat liver was higher by two-three orders of magnitude as compared to the effect of essentiale. In rats with a toxic hepatitis model induced by ethanol, lipophen restored the activity of mitochondria on a level characteristic of intact animals. In the case of CCl4-induced hepatitis, lipophen significantly increased the hydroxylase activity.
Gordienko
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Central Research Laboratory, Ukrainian Pharmaceutical Academy, ul. Pushkinskaya 53, Kharkov, 310002 Ukraine.
D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004338:Drug Combinations; D000431:Ethanol; D005419:Flavonoids / Q000627:therapeutic use*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D051381:Rats; D014815:Vitamins / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005419:Flavonoids; D010713:Phosphatidylcholines; D014815:Vitamins; C435543:lipophen; C011246:essential 303 forte; D000431:Ethanol