title: Vulvar Paget disease. Two cases with cytokeratin 7 and 20 expression.
abstract: Two cases of vulvar Paget's disease are described in two women aged 75 and 60 years, with onset several years earlier as eczema-like manifestations, and evolving into erosive, slightly infiltrative lesions. In both cases immunohistochemical examination revealed positivity for cytokeratins CK7 and CK20. This finding suggested the diagnosis of primitive vulvar Paget's disease, a relatively benign form, unlike the aggressive and rapidly progressive secondary vulvar Paget's disease.
authors.affiliation: Department of Dermatology, University of Siena, Italy. bilenchi@unisi.it
authors.forename: R
authors.initials: R
authors.lastname: Bilenchi
authors.forename: A
authors.initials: A
authors.lastname: Andreassi
authors.forename: R
authors.initials: R
authors.lastname: Santopietro
authors.forename: C
authors.initials: C
authors.lastname: Miracco
authors.forename: M
authors.initials: M
authors.lastname: Biagioli
authors.forename: C
authors.initials: C
authors.lastname: Cardone
authors.forename: L
authors.initials: L
authors.lastname: Andreassi
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007381:Intermediate Filament Proteins / Q000096:biosynthesis*; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins / Q000096:biosynthesis*; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000378:metabolism*; D014846:Vulvar Neoplasms / Q000378:metabolism*
chemical_list: D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; C507497:KRT7 protein, human; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins