How feasible is it to conform to the European guidelines on administration of activated charcoal within one hour of an overdose?
OBJECTIVE
The European and American position statement on the use of activated charcoal recommends its administration within an hour of ingestion of a charcoal binding poison. But in reality, this time limit is difficult to follow for the majority of poisoned patients. This study aimed to examine the treatment of acutely poisoned patients with activated charcoal in an accident and emergency (A&E) department.


METHODS
63 patients who had taken potentially serious overdoses and required hospital admission from a London teaching hospital A&E department were identified over a six month period. The patients' case notes were analysed for age, sex, substances taken, and the timing of their management within the A&E department.


RESULTS
Median time of arrival after overdose was 136 minutes, and only 15 patients presented within an hour. Ten of these 15 patients were given activated charcoal, and only four of the 10 received it within the one hour limit. Sixteen patients received charcoal outside the time limit. Subanalysis of the individual cases given charcoal shows that triaging is fast (median five minutes), but a significant time delay occurs after this before charcoal is administered (median 21 minutes).


CONCLUSIONS
These results are likely to be exaggerated in rural hospitals and demonstrate the difficulty of adhering to the recommended guidelines, unless activated charcoal can be safely administered to appropriate patients in the prehospital environment.
Karim
A
A
National Poisons Information Service, Guy's and St Thomas's NHS Trust, London SE14 5ER, UK. doctor@aminkarim.freeserve.co.uk
Ivatts
S
S
Dargan
P
P
Jones
A
A
D000293:Adolescent; D000328:Adult; D002606:Charcoal / Q000008:administration & dosage*; D062787:Drug Overdose / Q000628:therapy*; D004632:Emergency Medical Services / Q000592:standards*; D004739:England; D005060:Europe; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
D002606:Charcoal