title: Electromagnetic stimulation on the bone growth using backscattered electron imaging.
abstract: The events at the hydroxyapatite implant material/tissue interface following electromagnetic stimulation were studied in the rabbit. Two kinds of hydroxyapatite were used: natural (NA) and synthetic (HA) both with a grain size of <50 microm. Bone defects, artificially created in rabbit tibiae, were filled with the material examined. One group of animals was exposed immediately after surgery and every 12h thereafter to 30-min treatments with electromagnetic fields (PEMFs). A second group was used as a control (untreated). Two and 4 weeks after implantation, animals were sacrificed and bone samples processed for LM, TEM and SEM using a backscatter electron detector for the evaluation of bone growth. This study indicates that HA has more osteoconductivity than NA, and shows that PEMF-treatment results in a benefit in accelerating bone formation at early time periods.
authors.affiliation: Istituto di Anatomia Umana Normale, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy. ottani@biocfarm.unibo.it
authors.forename: V
authors.initials: V
authors.lastname: Ottani
authors.forename: M
authors.initials: M
authors.lastname: Raspanti
authors.forename: D
authors.initials: D
authors.lastname: Martini
authors.forename: G
authors.initials: G
authors.lastname: Tretola
authors.forename: A
authors.initials: A
authors.lastname: Ruggeri
authors.forename: M
authors.initials: M
authors.lastname: Franchi
authors.forename: G
authors.initials: G
authors.lastname: Giuliani Piccari
authors.forename: A
authors.initials: A
authors.lastname: Ruggeri
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001846:Bone Development; D017886:Durapatite; D004558:Electric Stimulation; D004574:Electromagnetic Fields; D005260:Female; D008855:Microscopy, Electron, Scanning / Q000379:methods; D019736:Prostheses and Implants; D011817:Rabbits; D013977:Tibia / Q000502:physiology* / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite