title: Elevation of serum IGF-1 rather than sex steroids precedes proliferative diabetic retinopathy in Mauriac's syndrome.
abstract: We report the case of a 21-year-old man with Mauriac's syndrome, in whom diabetic retinopathy progressed to the proliferative state despite slightly improved glycemic control and completely suppressed sex steroids (by a GnRH agonist). However, a gradual increase in serum IGF-1 from 162 to 482 ng/ml over 9 months clearly preceded retinal deterioration, which responded to panretinal laser coagulation. We conclude that substantial elevation of serum IGF-1 may be another risk factor for the progression of mild diabetic retinopathy to the proliferative state.
authors.affiliation: Department of Metabolic Diseases and Nutrition, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Chantelau
authors.forename: T
authors.initials: T
authors.lastname: Seppel
authors.forename: C
authors.initials: C
authors.lastname: Althaus
authors.forename: E
authors.initials: E
authors.lastname: Schönau
mesh_terms: D000328:Adult; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood* / Q000209:etiology*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006130:Growth Disorders / Q000097:blood / Q000150:complications*; D006529:Hepatomegaly / Q000150:complications; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D013577:Syndrome
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007334:Insulin-Like Growth Factor I