title: Nephrotoxicity of selective COX-2 inhibitors.
abstract: We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib. In the second patient, acute renal failure necessitated hemodialysis. Both patients made an uneventful recovery. Our report lends further support to the assumption that COX-2 inhibitors, as a class, can be as nephrotoxic as their nonselective predecessors. Therefore, COX-2 inhibitors should be used with caution in renal transplant recipients and in patients with salt depletion and renal insufficiency.
authors.affiliation: Department of Medicine, University of Hannover School of Medicine, Germany. Woywodt.Alexander@MH-Hannover.de
authors.forename: A
authors.initials: A
authors.lastname: Woywodt
authors.forename: A
authors.initials: A
authors.lastname: Schwarz
authors.forename: M
authors.initials: M
authors.lastname: Mengel
authors.forename: H
authors.initials: H
authors.lastname: Haller
authors.forename: H
authors.initials: H
authors.lastname: Zeidler
authors.forename: L
authors.initials: L
authors.lastname: Köhler
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000328:Adult; D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000188:drug therapy*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D007783:Lactones / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000175:diagnosis / Q000188:drug therapy*; D006435:Renal Dialysis / Q000379:methods; D018570:Risk Assessment; D013450:Sulfones
chemical_list: D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib