title: Radiation therapy in the treatment of canine and feline thymomas: a retrospective study (1985-1999).
abstract: A retrospective study was performed of 17 dogs and seven cats with various stages of thymoma treated with radiation alone or as an adjunctive therapy. Analysis revealed an overall response rate of 75% (15/20 evaluable cases). Partial (i.e., >50% reduction in tumor size) and complete (i.e., no detectable tumor) responses were included. Complete responses were rare (4/20). Three of five animals with stable disease (i.e., <50% change in tumor size) had improvements in clinical signs, despite lack of measurable response. A median survival time of 248 days (range, 93 to 1,657+ days) was achieved in dogs, and a median survival time of 720 days (range, 485 to 1,825+ days) was achieved in cats. Radiation therapy appears to be useful in the management of invasive thymomas in dogs and cats.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Alabama 36849, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Smith
authors.forename: J C
authors.initials: JC
authors.lastname: Wright
authors.forename: W R
authors.initials: WR
authors.lastname: Brawner
authors.forename: S M
authors.initials: SM
authors.lastname: LaRue
authors.forename: L
authors.initials: L
authors.lastname: Fineman
authors.forename: G S
authors.initials: GS
authors.lastname: Hogge
authors.forename: B E
authors.initials: BE
authors.lastname: Kitchell
authors.forename: A E
authors.initials: AE
authors.lastname: Hohenhaus
authors.forename: R L
authors.initials: RL
authors.lastname: Burk
authors.forename: R S
authors.initials: RS
authors.lastname: Dhaliwal
authors.forename: L E
authors.initials: LE
authors.lastname: Duda
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000401:mortality / Q000532:radiotherapy*; D002415:Cats; D004283:Dog Diseases / Q000401:mortality / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D008297:Male; D011996:Records / Q000662:veterinary; D012189:Retrospective Studies; D016019:Survival Analysis; D013945:Thymoma / Q000532:radiotherapy / Q000662:veterinary*; D013953:Thymus Neoplasms / Q000532:radiotherapy / Q000662:veterinary*; D016896:Treatment Outcome