Endocrine regulation of carbohydrate metabolism in hypometabolic animals.
Experimental hypothermia and natural hibernation are two forms of hypometabolism with recognized physiological changes, including depression of endocrine and metabolic functions.  To better understand functional changes, helox (i.e., helium and oxygen (80:20) mixtures) and low ambient temperatures have been used to induce hypothermia in hamsters and rats.  Both clinical and biological survival, i.e., survival without recovery and survival with recovery from hypothermia, respectively, are related to depth and length of hypothermia.  In the rat, body temperatures of 15 degrees C for periods greater than 6-10 h greatly restrict biological survival.  The role of glucocorticoids in enhancing thermogenic capacity of rats was assessed using triamcinolone [correction of triamcinalone] acetonide.  In the hamster, treatment with cortisone acetate prolonged both clinical and biological survival.  Hypothermic hamsters continue utilizing circulating glucose until they become hypoglycemic and die.  Hypothermic rats do not utilize glucose and respond with a significant hypoinsulinema.  The role of endocrines in the regulation of carbohydrate homeostasis and metabolism differs in hibernation and hypothermia.  Glucocorticoids influence the hypothermic response in both species, specifically by prolonging induction of hypothermia in rats and by prolonging survival in hypothermic hamsters.
Musacchia
X J
XJ
Department of Physiology and Biophysics, School of Medicine, University of Louisville, KY 40292.
D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D001831:Body Temperature; D050260:Carbohydrate Metabolism; D003080:Cold Temperature; D003348:Cortisone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D006224:Cricetinae; D006371:Helium; D006605:Hibernation / Q000187:drug effects* / Q000502:physiology; D007035:Hypothermia / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000379:methods*; D051379:Mice; D010100:Oxygen; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000494:pharmacology / Q000627:therapeutic use
D006371:Helium; D014222:Triamcinolone Acetonide; D010100:Oxygen; D003348:Cortisone