Establishment of Porphyromonas gingivalis-specific T-cell lines from atherosclerosis patients.
Porphyromonas gingivalis-specific T-cell lines were established from atherosclerotic lesions from two patients. T-cell lines were found to be a mixture of CD4+ and CD8+ T-cells producing variable amount of interferon-gamma, interleukin-4 and interleukin-10. The two patients have had a periodontal disease whose anti-P. gingivalis immunoglobulin G titers were significantly elevated, and P. gingivalis was the one of the predominantly cultivable microorganisms. This is the first report of the successful establishment of P. gingivalis-specific T-cell lines from atherosclerotic patients.
Choi
J
J
Department of Periodontology, School of Dentistry, Pusan National University, Pusan, Republic of Korea.
Chung
S W
SW
Kim
S J
SJ
Kim
S J
SJ
D000907:Antibodies, Bacterial / Q000097:blood; D001161:Arteriosclerosis / Q000382:microbiology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D002460:Cell Line; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D016966:Porphyromonas gingivalis / Q000276:immunology / Q000472:pathogenicity*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology*
D000907:Antibodies, Bacterial; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma