title: An alternative therapeutic procedure for sinonasal undifferentiated carcinoma.
abstract: We describe two cases of sinonasal undifferentiated carcinoma, a rare and highly aggressive neoplasm of the paranasal sinuses. Case 1 had first been diagnosed as esthesioneuroblastoma, and intra-arterial and systemic chemotherapy and radiotherapy were performed. The tumor became smaller but did not disappear, and the patient died 2 months later. Case 2 received systemic chemotherapy and chemoradiotherapy, with daily venous administration of cisplatin during radiotherapy. The tumor became much smaller but also remained, and the patient died a month later. Although the therapy failed, chemoradiotherapy has some possibility of controlling the disease.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Japan. sakamoto@rigid.com
authors.forename: M
authors.initials: M
authors.lastname: Sakamoto
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Nishimura
mesh_terms: D000293:Adolescent; D002277:Carcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D002648:Child; D003131:Combined Modality Therapy / Q000379:methods; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D017211:Treatment Failure