title: Non-subjective cataract analysis and its application in space radiation risk assessment.
abstract: Experimental animal studies and human observations suggest that the question is not whether or not prolonged space missions will cause cataracts to appear prematurely in the astronauts, but when and to what degree.  Historically the major impediment to radiation cataract follow-up has been the necessarily subjective nature of assessing the degree of lens transparency.  This has spurred the development of instruments which produce video images amenable to digital analysis.  One such system, the Zeiss Scheimpflug slit lamp measuring system (SLC), was incorporated into our ongoing studies of radiation cataractogenesis.  It was found that the Zeiss SLC measuring system has high resolution and permits the acquisition of  reproducible images of the anterior segment of the eye.  Our results, based on about 650 images of the rats lens, and followed over a period of 91 weeks of radiation cataract development, showed that the integrated optical density (IOD) of the lens correlated well with conventional assessment with the added advantages of objectivity, permanent and transportable records and linearity as cataracts become more severe.  This continuous data acquisition, commencing with cataract onset, can proceed through more advanced stages.  The SLC exhibits much greater sensitivity reflected in a continuously progressive severity despite the artifactual plateaus in staging which occur using conventional scoring methods.  Systems such as the Zeiss SLC should be used to monitor astronauts frequent visits to low earth orbit to obtain a longitudinal data-base on the influence of this activity on the lens.
authors.affiliation: Columbia University, Department of Ophthalmology, New York 10032, USA.
authors.forename: B
authors.initials: B
authors.lastname: Wu
authors.forename: C
authors.initials: C
authors.lastname: Medvedovsky
authors.forename: B V
authors.initials: BV
authors.lastname: Worgul
mesh_terms: D000818:Animals; D002386:Cataract / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D003359:Cosmic Radiation / Q000009:adverse effects*; D007091:Image Processing, Computer-Assisted; D015994:Incidence; D007477:Ions; D007501:Iron / Q000009:adverse effects; D007908:Lens, Crystalline / Q000528:radiation effects*; D008853:Microscopy / Q000379:methods; D010781:Photography / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D018570:Risk Assessment; D013026:Space Flight
chemical_list: D007477:Ions; D007501:Iron