title: Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides.
abstract: Nuclear accumulation of ODNs has been associated with their binding to a series of nuclear proteins. These interactions could be responsible for the sequence-independent effects of ODNs as well as for their sequence-specific interactions and their intracellular distribution. Investigation of interaction of ODNs with these proteins may shed light on the mechanisms of cellular uptake and nuclear accumulation of oligonucleotides.
authors.affiliation: Laboratory of Nucleic Acids Biochemistry, Novosibirsk Institute of Bioorganic Chemistry, 8 Lavrentiev Ave., Novosibirsk, 630090, Russia.
authors.forename: V
authors.initials: V
authors.lastname: Tomasi
authors.forename: P P
authors.initials: PP
authors.lastname: Laktionov
authors.forename: A V
authors.initials: AV
authors.lastname: Bryksin
authors.forename: N V
authors.initials: NV
authors.lastname: Volod'ko
authors.forename: C
authors.initials: C
authors.lastname: Griffoni
authors.forename: E Y
authors.initials: EY
authors.lastname: Rykova
authors.forename: E
authors.initials: E
authors.lastname: Spisni
authors.forename: R
authors.initials: R
authors.lastname: Kraft
authors.forename: V V
authors.initials: VV
authors.lastname: Vlassov
mesh_terms: D001667:Binding, Competitive; D002467:Cell Nucleus / Q000378:metabolism; D004727:Endothelium / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D009000:Monocytes / Q000201:enzymology / Q000378:metabolism; D009841:Oligonucleotides / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D009841:Oligonucleotides; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases