title: Combining high-throughput pharmacokinetic screens at the hits-to-leads stage of drug discovery.
abstract: Profound technological advances in the drug discovery process have led to the identification of an increasingly large number of promising compounds at the hits-to-leads stage. Higher-throughput pharmacokinetic screens have therefore been developed to enhance the tractability of selected leads and minimize the risk of failure in the later stages of drug development.
authors.affiliation: BioMet Discovery 1 BioMet Division GlaxoWellcome R&D Park Road, SG12 0DP, Ware Herts, UK
authors.forename: D J.M.
authors.initials: DJ
authors.lastname: Spalding
authors.forename: A J.
authors.initials: AJ
authors.lastname: Harker
authors.forename: M K.
authors.initials: MK
authors.lastname: Bayliss