[Quantitative studies of lysozyme and phosphohexose isomerase enzymes in mixed saliva in oral squamous epithelial carcinoma].
BACKGROUND
In connection with quantitative sialochemical investigations in mixed saliva from patients with oral squamous cell carcinoma (OPC), the enzymes phosphohexoseisomerase (PHI) and lysozyme (Ly) were investigated. The glycolytic enzyme PHI recently became interesting as a tumor marker. Lysozyme represents the main enzyme of the nonspecific salivary immune defense.


METHODS
The enzyme concentrations were specified in 25 men with OPC and in a control group of 20 healthy men of comparable age.


CONCLUSIONS
In the mixed saliva of the OPC patients, the PHI concentration was significantly diminished according to the Mann-Whitney-Wilcoxon test compared to the control group (p = 0.022). The lysozyme concentration, however, significantly increased (p = 0.011). These results prove serious sialochemical alterations in mixed saliva of OPC patients. They extend our former studies on kallikrein in glandular mixed saliva, but at present only have a descriptive character. Further pathobiochemical investigations on this subject should be carried out.
Meyer
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P
HNO-Klinik, Ernst-Moritz-Arndt-Universität, Walther-Rathenau-Strasse 43-45, 17487 Greifswald.
Zechel
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T
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000201:enzymology; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D009113:Muramidase / Q000378:metabolism*; D011237:Predictive Value of Tests; D012016:Reference Values; D012463:Saliva / Q000201:enzymology*
D014408:Biomarkers, Tumor; D009113:Muramidase; D005956:Glucose-6-Phosphate Isomerase