title: Surfactant lavage and replacement in meconium aspiration syndrome with pulmonary hemorrhage.
abstract: We reported two case studies of meconium aspiration syndrome (MAS) with pulmonary hemorrhage in which we applied surfactant lavage and replacement. Surfactant lavage and replacement of MAS with pulmonary hemorrhage appears to be effective and safe adjunctive therapy. The relatively small replacement doses of surfactant required may be attributed to surfactant lavage followed by surfactant replacement. We suggest that surfactant lavage and replacement of MAS with pulmonary hemorrhage should be further investigated by a randomized controlled trial.
authors.affiliation: Department of Pediatrics, Shizuoka Red Cross Hospital, Shizuoka-shi, Japan. src1@tokai.or.jp
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
authors.forename: J
authors.initials: J
authors.lastname: Watanabe
authors.forename: E
authors.initials: E
authors.lastname: Ueno
mesh_terms: D006470:Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D008171:Lung Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010100:Oxygen / Q000097:blood; D011663:Pulmonary Surfactants / Q000008:administration & dosage* / Q000627:therapeutic use; D011859:Radiography; D012121:Respiration, Artificial; D007507:Therapeutic Irrigation
chemical_list: D011663:Pulmonary Surfactants; D010100:Oxygen