title: Post-elution concentration of 99mTcO4- by a single anion exchanger column. I: Feasibility of extending the useful life of column chromatographic 99mTc generator.
abstract: 99mTc eluate in 0.7/0.35 M acetic acid and in 1:1 v/v 0.7 M acetic acid: 0.025 M ammonium acetate (30-40 ml) was conveniently concentrated by passing through a small column of a readily available weak anion exchanger, DEAE cellulose, (200 mg, 6 x 8 mm) and subsequent elution with 3 ml normal saline, with greater than 90% recovery. The quality of pertechnetate thus obtained and its compatibility for preparing 99mTc compounds were satisfactory. This method was successfully applied to the alumina column chromatographic generator produced in-house and to a commercial 99Mo-99mTc generator after extensive clinical use. Potential for much higher concentration factors with compacted anion exchanger cartridges as well as applicability for 188W-188Re generator are discussed.
authors.affiliation: Radiopharmaceutical Programme, Board of Radiation and Isotope Technology, Navi Mumbai, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Sarkar
authors.forename: G
authors.initials: G
authors.lastname: Arjun
authors.forename: P
authors.initials: P
authors.lastname: Saraswathy
authors.forename: N
authors.initials: N
authors.lastname: Ramamoorthy