Treatment of vascular thrombosis with enoxaparin in orthotopic heart transplant patients during the early postoperative period.
Management of anti-coagulation in the early period after orthotopic heart transplantation, when the frequency of invasive procedures to assess for graft rejection is high, presents a difficult clinical problem in which the need for effective therapy must be weighed against the desire for outpatient treatment. In this report, we summarize the clinical course and long-term outcome of 6 patients from our center in whom vascular thrombosis was treated on an outpatient basis with enoxaparin. We conclude that the use of enoxaparin may provide a safe and reasonable alternative to conventional anti-coagulation therapy during this period.
Lopshire
J C
JC
Indiana University School of Medicine, Indianapolis, Indiana, USA.
Darroca
A G
AG
Gradus-Pizlo
I
I
O'Donnell
J A
JA
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D001706:Biopsy; D017548:Echocardiography, Transesophageal; D017984:Enoxaparin / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000473:pathology; D016027:Heart Transplantation; D006801:Humans; D007196:Indiana; D008297:Male; D011184:Postoperative Period; D016896:Treatment Outcome; D018616:Ultrasonography, Doppler, Duplex; D014656:Vascular Surgical Procedures; D020246:Venous Thrombosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*
D000925:Anticoagulants; D017984:Enoxaparin