title: Thin film bioreactors in space.
abstract: Studies from the Skylab, SL-3 and D-1 missions have demonstrated that biological organisms grown in microgravity have changes in basic cellular functions such as DNA, mRNA and protein synthesis, cytoskeleton synthesis, glucose utilization and cellular differentiation.  Since microgravity could affect prokaryotic and eukaryotic cells at a subcellular and molecular level, space offers us an opportunity to learn more about basic biological systems with one important variable removed.  The thin film bioreactor will facilitate the handling of fluids in microgravity, under constant temperature and will allow multiple samples of cells to be grown with variable conditions.  Studies on cell cultures grown in microgravity would enable us to identify and quantify changes in basic biological function in microgravity which are needed to develop new applications of orbital research and future biotechnology.
authors.affiliation: Veterans Administration Medical Center, San Francisco, CA 94121.
authors.forename: M
authors.initials: M
authors.lastname: Hughes-Fulford
authors.forename: H W
authors.initials: HW
authors.lastname: Scheld
mesh_terms: D000818:Animals; D018488:Bone Demineralization, Pathologic / Q000473:pathology; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D003470:Culture Media; D004867:Equipment Design; D006801:Humans; D007185:Incubators; D010006:Osteoblasts / Q000166:cytology / Q000473:pathology; D013026:Space Flight / Q000295:instrumentation*; D014893:Weightlessness
chemical_list: D003470:Culture Media