title: Relationship between IFN-gamma production by blood lymphocytes and constitutional personality features of patients with idiopathic mitral valve prolapse.
abstract: Psychological testing using Eysenck Personality Inventory and immunological testing of 75 patients with idiopathic mitral valve prolapse revealed low production of interferon-gamma by blood lymphocytes and a correlation between interferon-gamma production and patient's temperament. Low neuroticism and extroversion scores were found in patients with normal interferon-gamma production. High neuroticism score was detected in 82% patients with lowest interferon-gamma production, which refers these patients to a group at high immunological risk and prompts the use of interferon and/or its inductors in complex therapy of these patients.
authors.affiliation: Laboratory of Pathophysiology, Center of Mental Health, Russian Academy of Medical Sciences, Moscow.
authors.forename: I D
authors.initials: ID
authors.lastname: Surkina
authors.forename: O
authors.initials: O
authors.lastname: Yu Sokolov
authors.forename: M V
authors.initials: MV
authors.lastname: Gabaeva
authors.forename: K G
authors.initials: KG
authors.lastname: Gurevich
authors.forename: M V
authors.initials: MV
authors.lastname: Alfimova
authors.forename: E V
authors.initials: EV
authors.lastname: Akatova
authors.forename: L S
authors.initials: LS
authors.lastname: Pak
mesh_terms: D000328:Adult; D005120:Extraversion, Psychological; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007439:Introversion, Psychological; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000097:blood / Q000276:immunology* / Q000523:psychology*; D019964:Mood Disorders / Q000276:immunology*
chemical_list: D007371:Interferon-gamma