[Effects of low concentration carbon monoxide on human physiological function].
Human volunteers were exposed to various low concentrations of carbon monoxide (CO) in a closed cabin. The results showed that 35 mg/m3 of CO caused slight subjective symptoms and reduction in contrast vision, operating efficiency and T-wave of ECG. At 80 mg/m3 and 115 mg/m3 the above changes were more severe and a rise in hearing threshold level was observed. It demonstrated that an inhibitory effect on the CNS and heart were caused by low concentrations of CO. According to the absorption curves for human exposed to CO, it is suggested that the sense effect level and vision effect level for CO are 7% COHb, and the hearing effect level is 9% COHb.
Yu
B
B
Institute of Space Medico-Engineering, Beijing, China.
Zhang
H
H
Mou
X
X
Yu
F
F
Zhong
H
H
He
Z
Z
D000337:Aerospace Medicine; D016902:Air Pollution, Indoor; D001309:Auditory Threshold / Q000187:drug effects*; D002248:Carbon Monoxide / Q000378:metabolism / Q000633:toxicity*; D002263:Carboxyhemoglobin / Q000378:metabolism / Q000633:toxicity*; D015350:Contrast Sensitivity / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D013647:Task Performance and Analysis
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin