New anti-malarial flavonol glycoside from Hydrangeae Dulcis Folium.
Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.
Murakami
N
N
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
Mostaqul
H M
HM
Tamura
S
S
Itagaki
S
S
Horii
T
T
Kobayashi
M
M
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D029628:Hydrangeaceae / Q000737:chemistry*; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000962:Antimalarials; D005419:Flavonoids; D006027:Glycosides