title: FR901469, a novel antifungal antibiotic from an unidentified fungus No. 11243. III. Structure determination.
abstract: A novel antifungal antibiotic, FR901469, was isolated from an unidentified fungus No. 11243. It is a water-soluble 40-membered macrocyclic lipopeptidolactone, consisting of D-Ala, L-Tyr, L-Val, trans-4OH-L-Pro, trans-3OH-L-Pro, threo-3OH-L-Gln, Gly, L-Orn, L-Thr, three residues of D-alloThr and a (3R)-hydroxypalmitic acid. Its structure, including absolute configurations, was unequivocally determined as 1 based on chemical and spectroscopic evidence.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Fujie
authors.forename: H
authors.initials: H
authors.lastname: Muramatsu
authors.forename: S
authors.initials: S
authors.lastname: Yoshimura
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: N
authors.initials: N
authors.lastname: Shigematsu
authors.forename: S
authors.initials: S
authors.lastname: Takase
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry*; D047630:Depsipeptides; D005658:Fungi / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000737:chemistry*; D055666:Lipopeptides
chemical_list: D000935:Antifungal Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C417112:FR 901469; D055666:Lipopeptides