title: Effect of space flight on cytokine production.
abstract: Space flight has been shown to alter many immunological responses. Among those affected are the production of cytokines. Cytokines are the messengers of the immune system that facilitate communication among cells that allow the interaction among cells leading to the development of immune responses. Included among the cytokines are the interferons, interleukins, and colony stimulating factors. Cytokines also facilitate communication between the immune system and other body systems, such as the neuroendocrine and musculoskeletal systems. Some cytokines also have direct protective effects on the host, such as interferon, which can inhibit the replication of viruses. Studies in both humans and animals indicate that models of space flight as well as actual space flight alter the production and action of cytokines.  Included among these changes are altered interferon production, altered responsiveness of bone marrow cells to granulocyte/monocyte-colony stimulating factor, but no alteration in the production of interleukin-3.  This suggests that there are selective effects of space flight on immune responses, i.e. not all cytokines are affected in the same fashion by space flight. Tissue culture studies also suggest that there may be direct effects of space flight on the cells responsible for cytokine production and action. The results of the above study indicate that the effects of space flight on cytokines may be a fundamental mechanism by which space flight not only affects immune responses, but also other biological systems of the human.
authors.affiliation: Department of Microbiology and Immunology, University of Louisville, KY 40292, USA.
authors.forename: G
authors.initials: G
authors.lastname: Sonnenfeld
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000096:biosynthesis / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis* / Q000502:physiology*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000502:physiology; D007378:Interleukins / Q000096:biosynthesis / Q000502:physiology; D051379:Mice; D051381:Rats; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*; D018474:Weightlessness Simulation
chemical_list: D003115:Colony-Stimulating Factors; D016207:Cytokines; D007378:Interleukins; D007372:Interferons