Torsade de pointes induced by ajmaline.
Ajmaline, a reserpine derivative, is an effective class I antiarrhythmic agent. Herein we report two cases of ajmaline-induced abnormal QT prolongation accompanied by polymorphic ventricular tachycardia of the torsade de pointes type. Since ajmaline is increasingly used for the acute termination of wide complex tachycardia and as a diagnostic tool after syncope and in patients with idiopathic ventricular tachyarrhythmias, our observations suggest that caution should be exercised with regard to the effects of the drug on the QT interval and its potency to induce proarrhythmia of the torsade de pointes type.
Haverkamp
W
W
Medizinische Klinik und Poliklinik, Innere Medizin C (Kardiologie, Angiologie) Westfälische Wilhelms-Universität Münster 48129 Münster, Germany. haverkw@uni-muenster.de
Mönnig
G
G
Kirchhof
P
P
Eckardt
L
L
Borggrefe
M
M
Breithardt
G
G
D000404:Ajmaline / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001282:Atrial Flutter / Q000188:drug therapy; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D013610:Tachycardia / Q000188:drug therapy; D017180:Tachycardia, Ventricular / Q000139:chemically induced; D016171:Torsades de Pointes / Q000139:chemically induced*
D000889:Anti-Arrhythmia Agents; D000404:Ajmaline