Delayed hypersensitivity skin testing to mumps and Candida albicans antigens is normal in middle-aged HTLV-I- and-II-infected U.S. cohorts.
It has been reported that human T cell lymphotropic virus (HTLV)-I-infected persons in Japan have decreased delayed hypersensitivity skin test reactivity to tuberculin purified protein derivative (PPD), but HTLV-I- or -II-infected persons do not generally develop opportunistic infections. We administered standardized intradermal testing with PPD, mumps, and Candida albicans antigens to 31 HTLV-I, 48 HTLV-II, and 143 seronegative subjects in the United States. Reactivity at 48 hr was compared among the three groups. Response rates to PPD were very low in all subjects. Fifty-five percent of seronegative subjects did not react to mumps antigen, compared with 55% of HTLV-I [adjusted odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.27-2.33] and 38% of HTLV-II (OR = 0.73, 95% CI 0.33-1.64). Fifty-one percent of seronegatives did not react to Candida albicans antigen, compared with 34% of HTLV-I (OR = 0.37, 95% CI 0.15-0.93) and 46% of HTLV-II (OR = 0.71, 95% CI 0.34-1.52). Anergy was present in 33% of seronegatives, 28% of HTLV-I (OR = 0.60, 95% CI 0.20-1.78), and 19% of HTLV-II (OR = 0.56, 95% CI 0.22-1.44). HTLV-I- and -II-infected persons appear to have intact delayed hypersensitivity skin test responses to mumps and Candida albicans antigens.
Murphy
E L
EL
University of California San Francisco, 94143, USA. murphy.itsa.ucsf.edu
Wu
Y
Y
Ownby
H E
HE
Smith
J W
JW
Ruedy
R K
RK
Thomson
R A
RA
Ameti
D I
DI
Wright
D J
DJ
Nemo
G J
GJ
D000328:Adult; D000946:Antigens, Fungal / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D015490:HTLV-I Infections / Q000276:immunology*; D015491:HTLV-II Infections / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009107:Mumps / Q000276:immunology*; D044469:Racial Groups; D012737:Sex Factors; D012882:Skin Tests; D014373:Tuberculin / Q000276:immunology; D014374:Tuberculin Test; D014481:United States
D000946:Antigens, Fungal; D014373:Tuberculin