Rapid RNA cleavage using an antisense system with two terpyridine.Cu(II) complexes.
An effective approach to promote sequence-specific RNA cleavage by an antisense 2'-O-methyloligonucleotide with a terpyridine.Cu(II) complex attached at the 5'-end was developed. We have synthesized a Cu(II) complex 3'-conjugate, which when used in a tandem fashion, greatly enhanced the RNA cleavage efficiency.
Inoue
H
H
Department of Bioapplied Chemistry, Faculty of Engineering, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka 558-8585, Japan.
Furukawa
T
T
Tamura
T
T
Kamada
A
A
Ohtsuka
E
E
D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012313:RNA / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism
D016376:Oligonucleotides, Antisense; D009942:Organometallic Compounds; D011725:Pyridines; D012313:RNA; D003300:Copper; C013278:2,2',2''-terpyridine