[Impaired maternal and fetal hemodynamics in the pathogenesis of gestosis].
The study was undertaken to examine the specific features of maternal and fetal hemodynamics in the pathogenesis of gestosis and to develop differential approaches to obstetric policy. For this, a total of 345 pregnant women at risk for gestosis were examined. This condition was prevented using aspirin and trental in 60 women. The findings suggest that hypokinetic central hemodynamics with increased total peripheral vascular resistance and with impaired blood flow in the uterine and spiral arteries are a valid predictor of gestosis. Changes in maternal hemodynamics are revealed just in the late first to early second trimester of gestation. The use of aspirin and trental in patients with hypokinetic central hemodynamics and impaired blood flow in the uterine and spiral arteries reduced the incidence of gestosis by 2.5 times, delayed intrauterine fetal development by 3 times.
Strizhakov
A N
AN
Musaev
Z M
ZM
Timokhina
T F
TF
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008962:Models, Theoretical; D010431:Pentoxifylline / Q000627:therapeutic use; D021041:Placental Circulation; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D011247:Pregnancy; D011379:Prognosis; D012307:Risk Factors; D016216:Ultrasonography, Prenatal; D014665:Vasodilator Agents / Q000627:therapeutic use
D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D001241:Aspirin; D010431:Pentoxifylline