[Pharmacological activity of immunomodulators in adjuvant arthritis].
Clinical features and functional activity of T- and B-cells were studied on the model of adjuvant arthritis which is the disease associated with activation of B-cells after monotherapy of rats with IM-1 (B-cell stimulator), dibazol (T-cell stimulator), alpha-tocopherol acetate (cintrol). It was established that B cells are most sensitive to the stimulation while T-cell reaction to the stimulators in disease is inhibited. Therefore, at early stages of arthritis and, probably, in other inflammatory diseases of autoimmune origin, stimulators of B-cells can be used for prophylaxis and treatment while at late stages--stimulators of T-cells.
Nezhinskaia
G I
GI
Sapronov
N S
NS
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D001562:Benzimidazoles / Q000627:therapeutic use; D004929:Esculin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D008297:Male; D011205:Povidone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D024505:Tocopherols; D024502:alpha-Tocopherol / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D001562:Benzimidazoles; C439589:N-vinylpyrrolidone-esculin copolymer; D004929:Esculin; C004453:bendazole; D011205:Povidone; D024502:alpha-Tocopherol; D024505:Tocopherols