[Effect of +Gz-induced cerebral ischemia on the distribution of nitric oxide synthase in rabbit brain].
In order to study the effect of repeated short termed + Gz -induced cerebral ischemia on rabbit brain, rabbits were exposed to +4.0 Gz for 3 times (with 30 min interval in between) which caused the arterial pressure at eye level dropped to 0 kPa and lasted for 30 s. Changes of distribution of the nitric oxide synthase(NOS) positive neurons in rabbit brain were observed using the NADPH-diaphorase histochemical reaction. The results showed that NOS positive neurons in the parietal cortex, piriform cortex, hippocampus and dentate gyrus increased by 167%, 126%, 321%, 172% (P < 0.01) respectively, immediately after repeated + Gz exposures, as compared with those of controls. It still remained significantly more than that in controls (P < 0.01) 1 h and 6 h after exposure. It suggests that NO may have some effect on the neurons during cerebral ischemia.
Li
J
J
Navy General Hospital, Beijing, China.
Wu
X
X
Dang
X
X
Sun
X
X
Zhao
H
H
Hua
Y
Y
D000054:Acceleration / Q000009:adverse effects; D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology / Q000503:physiopathology; D006624:Hippocampus / Q000502:physiology / Q000503:physiopathology; D018471:Hypergravity / Q000009:adverse effects*; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000209:etiology*; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010296:Parietal Lobe / Q000502:physiology / Q000503:physiopathology; D011817:Rabbits
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase