CNS-induced deficits of heavy particle irradiation in space: the aging connection.
Our research over the last several years has suggested that young (3 mo) rats exposed to whole-body 56Fe irradiation show neuronal signal transduction alterations and accompanying motor behavioral changes that are similar to those seen in aged (22-24 mo) rats. Since it has been postulated that 1-2% of the composition of cosmic rays contain 56Fe particles of heavy particle irradiation, there may be significant CNS effects on astronauts on long-term space flights which could produce behavioral changes that could be expressed during the mission or at some time after the return. These, when combined with other effects such as weightlessness and exposure to proton irradiations may even supercede mutagenic effects. It is suggested that by determining mechanistic relationships that might exist between aging and irradiation it may be possible to determine the common factor(s) involved in both perturbations and develop procedures to offset their deleterious effects. For example, one method that has been effective is nutritional modification.
Joseph
J A
JA
USDA Human Nutrition Research Center on Aging, Boston, MA 02111, USA.
Shukitt-Hale
B
B
McEwen
J
J
Rabin
B M
BM
D000375:Aging / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003359:Cosmic Radiation; D005419:Flavonoids / Q000494:pharmacology; D020450:Heavy Ions; D006801:Humans; D007501:Iron; D008560:Membrane Fluidity / Q000528:radiation effects*; D011835:Radiation Protection; D051381:Rats; D011976:Receptors, Muscarinic / Q000528:radiation effects; D015398:Signal Transduction / Q000187:drug effects / Q000528:radiation effects*; D013026:Space Flight; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects
D000975:Antioxidants; D005419:Flavonoids; D011976:Receptors, Muscarinic; D007501:Iron