title: Phosphoramidites and oligonucleotides containing 7-deazapurines and pyrimidines carrying aminopropargyl side chains.
abstract: The synthesis of phosphoramidites containing 7-deazaguanine, 7-deazaadenine, uracil and cytosine carrying aminopropargyl chains is described. The corresponding oligonucleotides are stabilized in duplexes thermally as well as against degradation by exonucleases.
authors.affiliation: Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Seela
authors.forename: N
authors.initials: N
authors.lastname: Ramzaeva
authors.forename: P
authors.initials: P
authors.lastname: Leonard
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Debelak
authors.forename: E
authors.initials: E
authors.lastname: Feiling
authors.forename: R
authors.initials: R
authors.lastname: Kröschel
authors.forename: M
authors.initials: M
authors.lastname: Zulauf
authors.forename: T
authors.initials: T
authors.lastname: Wenzel
authors.forename: T
authors.initials: T
authors.lastname: Fröhlich
authors.forename: M
authors.initials: M
authors.lastname: Kostrzewa
mesh_terms: D009841:Oligonucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D009943:Organophosphorus Compounds; D011687:Purines; D011743:Pyrimidines; C434331:phosphoramidite