Synthesis and hypoglycemic activity of some new flavone derivatives. 4th communication: 6-flavonyl-2,4-thiazolidinediones.
A new series of flavonyl compounds (1-10) was prepared and tested for their insulinotropic activities in INS-1 cells. Compounds 2, 5 and 6 (at higher concentrations) and compounds 3 and 7-10 were able to increase insulin release in the presence of 5.6 mmol/l glucose at both concentrations used (1 and 10 micrograms/ml).
Bozdağ-Dündar
O
O
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey.
Waheed
A
A
Verspohl
E J
EJ
Ertan
R
R
D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D005419:Flavonoids; D007004:Hypoglycemic Agents; D007328:Insulin; D013844:Thiazoles; D005947:Glucose