title: Impact of protease inhibitors on intrahepatic hepatitis C virus viral load.
abstract: During chronic hepatitis C, hepatitis C virus (HCV) load in plasma was shown to be higher in HIV-co-infected than in immunocompetent patients [1]. The reason for this increased HCV replication is not known. It may be as a result of HIV-induced immune deficiency [2], although some authors did not find any correlation with the CD4 cell count [3]. A direct interaction between HCV and HIV was also hypothesized [4]. Protease inhibitors (PI) used in highly active antiretroviral therapy (HAART) have no HCV reduction effect during the first months of treatment [5-8]. However, a decrease in HCV plasma load was recently described in patients treated with HAART for a year [9,10]. We therefore investigated the potential impact of HAART on intrahepatic HCV load.
authors.affiliation: Laboratoire de Virologie Systématique et Moléculaire, Centre Hospitalo-Universitaire Pellegrin, Bordeaux, France.
authors.forename: D
authors.initials: D
authors.lastname: Neau
authors.forename: P
authors.initials: P
authors.lastname: Trimoulet
authors.forename: M
authors.initials: M
authors.lastname: Winnock
authors.forename: B
authors.initials: B
authors.lastname: Le Bail
authors.forename: E
authors.initials: E
authors.lastname: Schvoerer
authors.forename: E
authors.initials: E
authors.lastname: Legrand
authors.forename: J M
authors.initials: JM
authors.lastname: Ragnaud
authors.forename: M
authors.initials: M
authors.lastname: Dupon
authors.forename: H
authors.initials: H
authors.lastname: Fleury
authors.forename: M E
authors.initials: ME
authors.lastname: Lafon
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D016174:Hepacivirus / Q000502:physiology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008099:Liver / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012367:RNA, Viral / Q000032:analysis / Q000097:blood
chemical_list: D011480:Protease Inhibitors; D012367:RNA, Viral