Secretion of a putative cytotoxin in multiple antibiotic resistant Salmonella enterica serotype Typhimurium phagetype DT104.
Salmonella enterica serotype Typhimurium phagetype DT104 (DT104) is a multiple antibiotic-resistant pathogen. DT104 infections have been reported in a multitude of hosts including humans, companion animals, livestock and wildlife. Recently, several isolates of DT104 were recovered from veal calves exhibiting abomasitis, a finding that is inconsistent with classic salmonellosis. One of these isolates was used in murine ligated loop experiments where it was observed that multiresistant DT104 can elaborate a putative cytotoxin. Thus it appears that DT104 has the ability to evade pharmacologic interventions, via antibiotic resistance, and elaborate a toxin that can damage cells.
Carlson
S A
SA
Preharvest Food Safety and Enteric Disease Research Unit, National Animal Disease Center, Ames, IA 50010, USA. scarlson@nadc.ars.usda.gov
Meyerholz
D K
DK
Stabel
T J
TJ
Jones
B D
BD
D000818:Animals; D001434:Bacteriophage Typing; D003603:Cytotoxins / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D007082:Ileum / Q000473:pathology; D051379:Mice; D012486:Salmonella typhimurium / Q000145:classification / Q000187:drug effects / Q000472:pathogenicity*; D012703:Serotyping
D003603:Cytotoxins