title: Changes in the loco-regional Cerebral Blood Flow (r.C.B.F.) during a simulation of weightlessness.
abstract: Experiments of prolonged bedrest in antiorthostatic position are conducted in order to simulated cardio-circulatory modifications observed in weightlessness. Until now, no studies of r.C.B.F. have been effected in these conditions. Six young, healthy volunteers (average age 23.8) were placed in strict bedrest and in antiorthostatic position -4 degrees for 7 days. The r.C.B.F. measurements were studied by 133Xe inhalation method using a 32 detectors system. Studies were made first in basal conditions, then between the 6th and 12th hr, and finally between the 72nd and the 78th hr after the beginning of the experiment. Three of the subjects received 0.450 mg of Clonidine daily during the experiment. In the subjects having taken no Clonidine, we observed a constant increase in r.C.B.F. (12, 17 and 16% respectively) in the first 12 hr; at the 72nd hour, all values had returned to basal state. This findings agrees with the well known notion of a rapid correction of hemodynamic disturbances observed in the first days of weightlessness. In the subjects treated with Clonidine, the increase of r.C.B.F. did not occur. Several mechanisms of action are possible; the Clonidine affecting either the heart by inhibiting volemic atrial receptors or the brain by direct vasoconstriction.
authors.affiliation: Department of Neurology, CHU Rangueil, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Guell
authors.forename: P h
authors.initials: Ph
authors.lastname: Dupui
authors.forename: M
authors.initials: M
authors.lastname: Barrere
authors.forename: G
authors.initials: G
authors.lastname: Fanjaud
authors.forename: A
authors.initials: A
authors.lastname: Bes
authors.forename: A
authors.initials: A
authors.lastname: Kotowskaia
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D001510:Bed Rest; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology*; D018495:Fluid Shifts / Q000187:drug effects / Q000502:physiology; D018475:Head-Down Tilt; D006801:Humans; D018474:Weightlessness Simulation
chemical_list: D000316:Adrenergic alpha-Agonists; D003000:Clonidine