[Correction by succinic acid of behavioral and physiological parameters of neurosis-like condition in white rats].
The neurosis-like state of white rats is accompanied by development of cerebral hypoxia. Negative symptoms of the neurosis-like state (behavioral, anatomic and energy) were decreased by per os administration of succinate (30 mg/kg) during the second half of the neurotization process. Succinate provided chiefly the delayed action on the system arterial tension, on the succinate dehydrogenase and NADH dehydrogenase activity. The effects depended on the propensity of a rat to the catatonic "freezing". The "freezing" was detected by a specific breathing pattern: a short inhale and a long pause. In "freezing" rats succinate corrected the system tension to a greater extent, while in "non-freezing" animals it corrected to a greater extent the succinate and NADH dehydrogenase activities. The positive effect of succinate administration is probably associated with its antihypoxic properties.
Aĭrapetiants
M G
MG
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Levshina
I P
IP
Nozdracheva
L V
LV
Shuĭkin
N N
NN
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D002389:Catatonia / Q000523:psychology; D008297:Male; D009245:NADH Dehydrogenase / Q000378:metabolism; D009497:Neurotic Disorders / Q000201:enzymology / Q000503:physiopathology* / Q000523:psychology*; D010991:Plethysmography; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D019802:Succinic Acid / Q000494:pharmacology*
D019802:Succinic Acid; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase