title: A multisite case report on the clinical use of sevoflurane in dogs.
abstract: The purpose of this report was to evaluate the clinical safety and efficacy of sevoflurane as an inhalant anesthetic in dogs. Subjective and objective data from 196 clinical cases utilizing sevoflurane as the maintenance anesthetic was collected at three sites. After preanesthetic evaluation, the attending anesthesiologist assigned the dogs to one of the following six anesthetic protocols: protocol 1, oxymorphone premedication and thiopental induction; protocol 2, oxymorphone/acetylpromazine premedication and thiopental induction; protocol 3, xylazine/butorphanol premedication and thiopental induction; protocol 4, opioid premedication and propofol induction; protocol 5, optional premedication and mask induction with sevoflurane in oxygen; and protocol 6, optional premedication and optional induction. The average quality of induction, maintenance, and recovery was good to excellent in all protocols. The three most common side effects during maintenance and recovery were hypotension, tachypnea, and apnea. Sevoflurane produces anesthesia in dogs comparable to the other inhalation anesthetics currently used (i.e., halothane and isoflurane) for diagnostic or therapeutic procedures.
authors.affiliation: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Branson
authors.forename: J E
authors.initials: JE
authors.lastname: Quandt
authors.forename: E A
authors.initials: EA
authors.lastname: Martinez
authors.forename: G L
authors.initials: GL
authors.lastname: Carroll
authors.forename: C M
authors.initials: CM
authors.lastname: Trim
authors.forename: J R
authors.initials: JR
authors.lastname: Dodam
authors.forename: S M
authors.initials: SM
authors.lastname: Hartsfield
authors.forename: N S
authors.initials: NS
authors.lastname: Matthews
authors.forename: A
authors.initials: A
authors.lastname: Mackenthun
authors.forename: M H
authors.initials: MH
authors.lastname: Beleau
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004285:Dogs / Q000502:physiology*; D004334:Drug Administration Schedule; D005260:Female; D005845:Georgia; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D008923:Missouri; D011292:Premedication; D012018:Reflex / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*; D000077149:Sevoflurane; D013781:Texas
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane