title: Collagen sponge repair of small cerebrospinal fluid leaks obviates tissue grafts and cerebrospinal fluid diversion after pituitary surgery.
abstract: OBJECTIVE
  Repair of a cerebrospinal fluid (CSF) leak created at the time of transsphenoidal surgery typically involves placement of a fat, fascial, or muscle graft and sellar floor reconstruction. In this report, a simplified repair for small, "weeping" CSF leaks using collagen sponge is described.
  
  
  METHODS
  All patients underwent an endonasal transsphenoidal procedure using the operating microscope. At the completion of tumor removal, if a small CSF leak was noted but no obvious large arachnoidal defect was present, a piece of collagen sponge was fashioned to cover the exposed diaphragma sellae. Titanium mesh was then wedged into the intrasellar, extradural space and a larger piece of collagen was placed over the reconstructed sellar floor. Nasal packing was removed within 24 hours.
  
  
  RESULTS
  During an 18-month period, 62 consecutive transsphenoidal procedures were performed for tumor removal. Of 20 patients with a small CSF leak (18 pituitary adenomas, 1 Rathke's cleft cyst, and 1 chordoma), all had successful repair with collagen sponge. At follow-up examinations at 1 to 18 months, no patient had required a lumbar drain or had developed meningitis. One other patient had a large intraoperative arachnoidal defect that was unsuccessfully repaired with the collagen sponge technique; in this patient, a second operation was required with a fat graft, sellar floor reconstruction, and lumbar drainage.
  
  
  CONCLUSIONS
  A simplified repair of small CSF leaks after transsphenoidal surgery using a two-layered collagen sponge technique with sellar floor reinforcement is thought to be safe and effective and obviates the need for tissue grafts, fibrin glue, or lumbar drain placement.
authors.affiliation: Division of Neurosurgery, University of California at Los Angeles Medical Center, Los Angeles, CA 90095-7039, USA. dkelly@mednet.ucla.edu
authors.forename: D F
authors.initials: DF
authors.lastname: Kelly
authors.forename: R J
authors.initials: RJ
authors.lastname: Oskouian
authors.forename: I
authors.initials: I
authors.lastname: Fineman
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000601:surgery*; D002559:Cerebrospinal Fluid Rhinorrhea / Q000175:diagnosis / Q000601:surgery*; D002817:Chordoma / Q000601:surgery; D003094:Collagen; D003397:Craniopharyngioma / Q000175:diagnosis / Q000601:surgery; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis / Q000601:surgery*; D019736:Prostheses and Implants; D012086:Reoperation; D012189:Retrospective Studies; D012658:Sella Turcica / Q000473:pathology / Q000601:surgery; D013524:Surgical Flaps; D015503:Surgical Sponges
chemical_list: D003094:Collagen