Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast.
Five unique metabolites, xyloketals A (1), B (2), C (3), D (4), and E (5), and the known 6 were isolated from mangrove fungus Xylaria sp. (no. 2508), obtained from the South China Sea. The structures of these compounds were elucidated by spectroscopic and X-ray diffraction experiments. Xyloketal A is a ketal compound with a C(3) symmetry and xyloketals B-E are its analogues. It was found that xytoketal C slowly rearranged to xytoketal B in DMSO-d(6)() solution at room temperature. Xyloketal A exhibited the activity of inhibiting acetylcholine esterase.
Lin
Y
Y
Department of Applied Chemistry, Zhongshan University, Guangzhou, P. R. China.
Wu
X
X
Feng
S
S
Jiang
G
G
Luo
J
J
Zhou
S
S
Vrijmoed
L L
LL
Jones
E B
EB
Krohn
K
K
Steingröver
K
K
Zsila
F
F
D000110:Acetylcholinesterase / Q000187:drug effects; D001210:Asia, Southeastern; D001685:Biological Factors / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry*; D008386:Marine Biology; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology*
D001685:Biological Factors; D002800:Cholinesterase Inhibitors; D011714:Pyrans; C438053:xyloketal A; D000110:Acetylcholinesterase