Reduced bone mineral density in HIV-positive individuals.
A total of 105 HIV-positive patients underwent dual-energy X-ray absorbtiometry (DEXA) scan to assess bone mineral density (BMD). The prevalence of reduced BMD was found to be 71% and was higher in patients who had ever been treated with protease inhibitors (PI). Our results suggest a possible association between PI and reduced BMD, and further complicate the debate regarding when to commence treatment of HIV and with what agents to start.
Moore
A L
AL
Centre for HIV Medicine, Royal Free Hospital, London, UK.
Vashisht
A
A
Sabin
C A
CA
Mocroft
A
A
Madge
S
S
Phillips
A N
AN
Studd
J W
JW
Johnson
M A
MA
D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000009:adverse effects*
D011480:Protease Inhibitors