Effects of hyper +Gz acceleration on cardiovascular function, visual evoked potentials and cerebral blood flow in anesthetized rats.
Sustained hyper-gravity acceleration, particularly along the long axis of the body of animals or man (Gz), produces significant mal-effects on subjects, and hence it has been well studied, The most common syndromes of Gz application were cardio-vascular de-conditioning, and black-out, red-out, and loss of consciousness, which finally lead subjects into death. However, in most previous studies, the duration of applied Gz was rather short. In the present experiments, we can use longer duration of 1000 seconds.  In addition, recent technological innovation make it possible to record directly local cerebral blood flow at a target cortical area with a Laser Doppler flow meter. We used this innovated method to measure local cerebral blood flow of rats in relation to visual evoked potentials (VEPs) under hyper-Gz acceleration. Also we recorded cardio-vascular parameters like heart rate from ECG, systolic and diastolic blood pressure and correlated them with cerebral blood flow and VEPs.
Matsunami
K
K
Institute of Equilibrium Research, Gifu University School of Medicine, Japan.
Satake
H
H
Konishi
T
T
D000054:Acceleration / Q000009:adverse effects*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D018471:Hypergravity / Q000009:adverse effects*; D009026:Mortality; D051381:Rats; D017208:Rats, Wistar; D013318:Stroke Volume / Q000502:physiology