Protooncogenes subserve memory formation in the adult CNS.
Studies of the signal transduction mechanisms underlying learning and memory have provided many new insights into the molecular mechanisms underlying associative conditioning in mammals. In this issue of Neuron, Gean and colleagues report the discovery that the PI-3 kinase/AKT(PKB) pathway contributes to LTP and the consolidation of amygdala-dependent cued fear conditioning in rats.
Sweatt
J D
JD
Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology; D008568:Memory / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D011519:Proto-Oncogenes / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D019869:Phosphatidylinositol 3-Kinases