Subpicosecond conformational dynamics of small peptides probed by two-dimensional vibrational spectroscopy.
The observation of subpicosecond fluctuations in the conformation of a small peptide in water is demonstrated. We use an experimental method that is specifically sensitive to conformational dynamics taking place on an ultrafast time scale. Complementary molecular-dynamics simulations confirm that the conformational fluctuations exhibit a subpicosecond component, the time scale and amplitude of which agree well with those derived from the experiment.
Woutersen
S
S
Max-Born-Institute for Nonlinear Optics and Short Pulse Spectroscopy, Max-Born-Strasse 2A, D-12489 Berlin, Germany.
Mu
Y
Y
Stock
G
G
Hamm
P
P
D003198:Computer Simulation; D003903:Deuterium; D007700:Kinetics; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation; D013055:Spectrophotometry, Infrared / Q000379:methods; D013997:Time Factors; D014732:Vibration
D009842:Oligopeptides; C039944:alanyl-alanyl-alanine; D003903:Deuterium