Mammaglobin is found in breast tissue as a complex with BU101.
The mammaglobin gene has been shown to be preferentially expressed in breast tissue. Few genes match its specificity. Mammaglobin has generated much interest, and studies are ongoing to develop diagnostic tests for breast cancer based on the detection of mammaglobin. While searching the Incyte Genomics Lifeseq database for tissue-specific markers, we observed a second secretoglobin, BU101, also known as lipophilin B. We report here that mammaglobin, in breast tissue, is found as a complex with BU101. The complex was isolated from breast cancer tissue and was characterized as the biologically relevant form of mammaglobin.
Colpitts
T L
TL
Breast Cancer Venture, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA.
Billing-Medel
P
P
Friedman
P
P
Granados
E N
EN
Hayden
M
M
Hodges
S
S
Menhart
N
N
Roberts
L
L
Russell
J
J
Stroupe
S D
SD
D000595:Amino Acid Sequence; D000943:Antigens, Differentiation / Q000302:isolation & purification; D001940:Breast / Q000737:chemistry*; D001943:Breast Neoplasms / Q000737:chemistry*; D002352:Carrier Proteins / Q000145:classification / Q000276:immunology / Q000302:isolation & purification* / Q000378:metabolism; D002460:Cell Line; D016208:Databases, Factual; D000939:Epitopes; D005260:Female; D005914:Globins / Q000145:classification / Q000276:immunology / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D060785:Mammaglobin A; D008969:Molecular Sequence Data; D009185:Myelin Proteins; D009363:Neoplasm Proteins / Q000145:classification / Q000276:immunology / Q000302:isolation & purification* / Q000378:metabolism; D010446:Peptide Fragments / Q000276:immunology; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism; D011510:Proteolipids; D060765:Secretoglobins; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014598:Uteroglobin / Q000145:classification / Q000276:immunology / Q000302:isolation & purification* / Q000378:metabolism
D000943:Antigens, Differentiation; D002352:Carrier Proteins; D000939:Epitopes; D060785:Mammaglobin A; D009185:Myelin Proteins; D009363:Neoplasm Proteins; D010446:Peptide Fragments; D011506:Proteins; D011510:Proteolipids; C556464:SCGB1D2 protein, human; C556448:SCGB2A2 protein, human; D060765:Secretoglobins; D005914:Globins; D014598:Uteroglobin