Application of PNA and LNA oligomers to chemotherapy.
Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.
Elayadi
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Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75390-9041, USA.
Corey
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DR
D000818:Animals; D006801:Humans; D009696:Nucleic Acids / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use; D020135:Peptide Nucleic Acids / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D016914:Ribonuclease H / Q000378:metabolism; D019098:Telomerase / Q000037:antagonists & inhibitors
D009696:Nucleic Acids; D016376:Oligonucleotides, Antisense; D020135:Peptide Nucleic Acids; D019098:Telomerase; D016914:Ribonuclease H