DPB1*8601, a previously unrecognized DPB1 variant in the Caucasoid population.
A new, previously unrecognized DPB1* allele, DPB1*8601, was found in a Swedish family. The new allele was carried on the common North European haplotype HLA A1-B8-DR3. Both individuals carrying the new allele were initially typed as clear DPB1*4601,*6601 but after family studies and further typing with allele-specific primers it was concluded that a new allele was present together with the common DPB1*0401. The new allele was investigated by direct sequencing of exon 2 in both forward and reverse directions employing intron primers combined with either an allele-specific sense or anti-sense biotinylated primer for bi-directional sequencing. The new allele is identical to DPB1*1701 in the five first variable regions. In the sixth region, however, DPB1*8601 carries the GGPM motif shared by several common alleles such as DPB1*0201 and 0401and 0402.
Bengtsson
M
M
Section of Clinical Immunology, Department of Oncology, Radiology and Clinical Immunology, Rudbeck Laboratory, University Hospital, Uppsala, Sweden. Mats.Bengtsson@klinimm.uu.se
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D005091:Exons / Q000235:genetics*; D014644:Genetic Variation; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006239:Haplotypes; D006579:Heterozygote; D006650:Histocompatibility Testing; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D008969:Molecular Sequence Data; D010375:Pedigree; D016415:Sequence Alignment; D044465:White People / Q000235:genetics*
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D007135:Immunoglobulin Variable Region