TP53 mutation patterns in breast cancers: searching for clues of environmental carcinogenesis.
Mutations in the tumour suppressor gene TP53 occur in about 30% of breast cancers. We have used the IARC TP53 mutation database to analyse the pattern of mutations in breast cancers (1392 mutations). The global pattern of mutations is similar to the one of most other cancers, but there is an excess of transversions on G bases in tumours from Western (USA and Europe) as compared to Eastern (Japan) countries. Moreover, the patterns of inherited TP53 mutations associated with breast cancer, differ from those of somatic mutations. These differences support the hypothesis that a fraction of breast cancer mutations occur as a consequence of environmental exposures.
Olivier
M
M
Group of Molecular Carcinogenesis, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, 69372 Lyon cedex08, France
Hainaut
P
P
D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000235:genetics*; D003062:Codon; D019992:Databases as Topic; D004781:Environmental Exposure; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors
D003062:Codon