title: Centrosome duplication: three kinases come up a winner!
abstract: Despite over one hundred years of research, the duplication of the centrosome is a poorly understood process. Three recent papers--exploring three different kinases--may have provided the answer.
authors.affiliation: University of Massachusetts Medical School, Department of Cell Biology, 377 Plantation Street, Worcester, Massachusetts 01605, USA.
authors.forename: E H
authors.initials: EH
authors.lastname: Hinchcliffe
authors.forename: G
authors.initials: G
authors.lastname: Sluder
mesh_terms: D000818:Animals; D042846:CDC2-CDC28 Kinases; D029742:Caenorhabditis elegans Proteins; D002453:Cell Cycle / Q000502:physiology; D018385:Centrosome / Q000502:physiology*; D019927:Cyclin E / Q000378:metabolism / Q000502:physiology; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases / Q000378:metabolism* / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D009687:Nuclear Proteins / Q000378:metabolism; D009697:Nucleolus Organizer Region / Q000378:metabolism; D000090243:Nucleophosmin; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D036082:Receptor, EphA1
chemical_list: D029742:Caenorhabditis elegans Proteins; D019927:Cyclin E; D009687:Nuclear Proteins; D000090243:Nucleophosmin; D011494:Protein Kinases; C441620:Ttk protein, mouse; C429649:zyg-1 protein, C elegans; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D036082:Receptor, EphA1; D017346:Protein Serine-Threonine Kinases; D042846:CDC2-CDC28 Kinases; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases