title: The determination of fracture mechanics properties of pharmaceutical materials in mode III loading using an anti-clastic plate bending method.
abstract: Powder compacts made from acetylsalicylic acid and lactose monohydrate were subjected to an anti-clastic plate bending method in order to obtain the critical stress intensity factor in mode III loading (tearing or antiplane shear mode). The theoretical approach for data processing was based on linear elastic fracture mechanics. In contrast to mode I loading (opening or tensile mode), where above a critical threshold value the critical stress intensity factor is independent of the notch depth, i.e. converts into a true material constant, in mode III loading the critical stress intensity factor could only be presented under strict reference to a defined notch length. For lactose monohydrate, the typical exponential relationship between critical stress intensity factor and plate porosity was found. However, this was not the case for acetylsalicylic acid plates, indicating a change in fracture origin from pores and clusters of pores at higher porosities to machine flaws at low porosities. Hence, no extrapolation to zero porosity was attempted for this material, whereas for lactose monohydrate, the critical stress intensity factor at zero porosity was estimated to be 102+/-14 MNm(3/2). This value is valid for a notch depth of 4.9+/-0.3 mm. From the values obtained for the critical stress intensity factor and the critical strain energy release rate in mode III loading and an anisotropy ratio, here defined as the ratio between the critical stress intensity factors obtained in mode I and mode III loading, it was concluded that acetylsalicylic acid is the more brittle material and that lactose monohydrate behaved rather ductile under the given experimental conditions.
authors.affiliation: Department of Pharmaceutics, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N1AX, UK. fridun.podczeck@ams1.ulsop.ac.uk
authors.forename: F
authors.initials: F
authors.lastname: Podczeck
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D007785:Lactose; D011208:Powders; D013314:Stress, Mechanical; D013678:Technology, Pharmaceutical
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011208:Powders; D007785:Lactose; D001241:Aspirin