Syndecan-4 and focal adhesion function.
Two groups have now reported the viability of mice that lack syndecan-4. These mice have wound healing/angiogenesis problems, and fibroblasts from these animals differ in adhesion and migration from normal. This is consistent with recent in vitro data indicating a need for signaling via syndecan-4 for focal adhesion formation, and reports that overexpression of proteins that bind syndecan-4 can modify cell adhesion and migration.
Woods
A
A
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA. awoods@cellbio.bhs.uab.edu
Couchman
J R
JR
D000818:Animals; D022001:Focal Adhesions / Q000502:physiology*; D016023:Integrins / Q000502:physiology; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D017434:Protein Structure, Tertiary; D011509:Proteoglycans / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D053671:Syndecan-4; D014945:Wound Healing
D016023:Integrins; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508306:Sdc4 protein, mouse; D053671:Syndecan-4