Long-term urological complications in survivors younger than 15 months of advanced stage abdominal neuroblastoma.
OBJECTIVE
We evaluated the long-term urological complications in survivors of infant advanced stage abdominal neuroblastoma.


METHODS
The records of patients who presented during an 8-year period with surgical problems related to the kidney and who had survived advanced stage (IV and IV-S) neuroblastoma were reviewed.


RESULTS
Of 7 patients identified 3 had complications of obstruction from retroperitoneal fibrosis and 4 had renal cell carcinoma. In the renal cell carcinoma group 3 patients had synchronous, multifocal, bilateral tumors and 1 had a tumor in a solitary kidney. Pathological examination of renal cell carcinoma revealed oncocytoidy with solid and papillary patterns. One patient underwent bilateral nephrectomy but in the remaining 3 renal preservation surgery was performed. All 7 patients have no progression of secondary complications 2 to 8 years after initial presentation.


CONCLUSIONS
Survivors of advanced stage abdominal neuroblastoma may be predisposed to long-term urological complications well after initial diagnosis. Because of the risk of renal damage from obstruction secondary to retroperitoneal fibrosis, and the propensity to have renal cell carcinoma, close long-term followup using abdominal imaging is recommended.
Koyle
M A
MA
Department of Pediatric Urology, Children's Hospital and University of Colorado School of Medicine, Denver, Colorado, USA.
Hatch
D A
DA
Furness
P D
PD
Lovell
M A
MA
Odom
L F
LF
Kurzrock
E A
EA
D000008:Abdominal Neoplasms / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000453:epidemiology* / Q000209:etiology; D007680:Kidney Neoplasms / Q000453:epidemiology*; D008297:Male; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D009447:Neuroblastoma / Q000150:complications* / Q000473:pathology; D012189:Retrospective Studies; D017741:Survivors; D013997:Time Factors