[Effect of moxonidine on the cardiac chronotropic regulation in hypertensive rats SHR-SP].
The administration of moxonidine for two weeks in a daily dose of 2 or 10 mg/kg (p.o.) reduced the cardiac sympathetic tone in stroke-prone spontaneously hypertensive rats (SHR-SP) by 24.3 +/- 7.3 and 32.2 +/- 10.2%, respectively. In addition, the treatment influenced the cardiac baroreflex by decreasing the bradycardic plateau and increasing both bradycardic and tachycardic range. The baroreflex gain increased in a dose-dependent manner by 41.6 +/- 12.1 and 103.0 +/- 3.9%, respectively. These data indicate that moxonidine can modulate the cardiac autonomic (tonic and reflex) chronotropic control.
Khokhlova
O N
ON
Pharmacology Group, Pushchino Department, Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142292 Russia.
Murashov
A N
AN
Lavrova
L N
LN
Medvedev
O S
OS
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001262:Atenolol / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D017704:Baroreflex / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D018342:Receptors, Adrenergic, beta-1 / Q000187:drug effects; D013565:Sympatholytics / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D007093:Imidazoles; D018727:Muscarinic Antagonists; D010276:Parasympatholytics; D018342:Receptors, Adrenergic, beta-1; D013565:Sympatholytics; D001262:Atenolol; D001285:Atropine; C043482:moxonidine