title: Anesthetic effects of ketamine or isoflurane induction prior to isoflurane anesthesia in medetomidine-premedicated dogs.
abstract: Dogs were given medetomidine (10 microg/kg body weight, intramuscularly) followed in 10 minutes by either ketamine (4 mg/kg body weight, intravenously) or isoflurane mask induction and maintained on isoflurane for 30 minutes. Medetomidine induced lateral recumbency in all dogs. Endotracheal intubation was faster and smoother when dogs were given ketamine than when induced with isoflurane. Analgesia was excellent in all groups. Respiratory depression was more profound when dogs were given ketamine. Recovery quality was smooth and similar among all groups. Medetomidine-premedicated dogs could be induced with either ketamine or isoflurane and maintained on 1.3% isoflurane to achieve good analgesia with smooth recovery from anesthesia.
authors.affiliation: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32608, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Ko
authors.forename: S M
authors.initials: SM
authors.lastname: Fox
authors.forename: R E
authors.initials: RE
authors.lastname: Mandsager
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001784:Blood Gas Analysis; D018592:Cross-Over Studies; D004285:Dogs / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D020926:Medetomidine / Q000008:administration & dosage; D011292:Premedication; D011897:Random Allocation; D012119:Respiration
chemical_list: D000778:Anesthetics, Dissociative; D018685:Anesthetics, Inhalation; D006993:Hypnotics and Sedatives; D007649:Ketamine; D007530:Isoflurane; D020926:Medetomidine