title: 2'C-alkoxy and 2'-C-aryloxy derivatives of N-(2-phosphonomethoxyethyl)-purines and -pyrimidines: synthesis and biological activity.
abstract: A series of novel, unusual type of acyclic phosphonate-based nucleotide analogues related to well-known antivirals (PMEA and HPMPA) was synthesized using easily available synthon. These compounds, which are distinguished for the presence of phosphonomethyl acetal linkage, form a group of derivatives that contribute to the understanding of structure-activity relationship within the area of acyclic nucleotide analogues.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Science of the Czech Republic, Prague.
authors.forename: D
authors.initials: D
authors.lastname: Rejman
authors.forename: M
authors.initials: M
authors.lastname: Masojídková
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: I
authors.initials: I
authors.lastname: Rosenberg
mesh_terms: D016588:Anticarcinogenic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004267:DNA Viruses / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D006839:Hydrocarbons, Acyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012190:Retroviridae / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
chemical_list: D016588:Anticarcinogenic Agents; D006839:Hydrocarbons, Acyclic; D011687:Purines; D011743:Pyrimidines