title: Effect of spaceflight on the isotonic contractile properties of single skeletal muscle fibers in the rhesus monkey.
abstract: Experiments from both Cosmos and Space Shuttle missions have shown weightlessness to result in a rapid decline in the mass and force of rat hindlimb extensor muscles. Additionally, despite an increased maximal shortening velocity, peak power was reduced in rat soleus muscle post-flight. In humans, declines in voluntary peak isometric ankle extensor torque ranging from 15-40% have been reported following long- and short-term spaceflight and prolonged bed rest. Complete understanding of the cellular events responsible for the fiber atrophy and the decline in force, as well as the development of effective countermeasures, will require detailed knowledge of how the physiological and biochemical processes of muscle function are altered by spaceflight. The specific purpose of this investigation was to determine the extent to which the isotonic contractile properties of the slow- and fast-twitch fiber types of the soleus and gastrocnemius muscles of rhesus monkeys (Macaca mulatta) were altered by a 14-day spaceflight.
authors.affiliation: Department of Biology, Marquette University, Milwaukee, WI, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Fitts
authors.forename: J G
authors.initials: JG
authors.lastname: Romatowski
authors.forename: C
authors.initials: C
authors.lastname: Blaser
authors.forename: L
authors.initials: L
authors.lastname: De La Cruz
authors.forename: G J
authors.initials: GJ
authors.lastname: Gettelman
authors.forename: J J
authors.initials: JJ
authors.lastname: Widrick
mesh_terms: D000818:Animals; D008253:Macaca mulatta; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D018656:Muscle Fibers, Fast-Twitch / Q000473:pathology; D018657:Muscle Fibers, Slow-Twitch / Q000473:pathology*; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009133:Muscular Atrophy / Q000209:etiology / Q000503:physiopathology; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*