title: Cardiac factors in orthostatic hypotension.
abstract: Cardiac function is determined by preload, afterload, heart rate and contractility.  During orthostatic stress, the footward blood shift is compensated for by an increase of afterload. LBNP is widely used to analyze effects of volume displacement during orthostatic stress. Comparisons of invasive (right heart catheterization) and non-invasive approach (echocardiography) yielded similar changes. Preload and afterload change with graded LBNP, heart rate increases, and stroke volume and cardiac output decrease. Thus, the working point on the left ventricular function curve is shifted to the left and downward, similar to hypovolemia. However, position on the Frank-Starling curve, the unchanged ejection fraction, and the constant Vcf indicate a normal contractile state during LBNP. A decrease of arterial oxygen partial pressure during LBNP shows impaired ventilation/ perfusion ratio. Finally, LBNP induced cardiac and hemodynamic changes can be effectively countermeasured by dihydroergotamine, a potent venoconstrictor. Comparison of floating catheter data with that of echocardiography resulted in close correlation for cardiac output and stroke volume.  In addition, cardiac dimensions changed in a similar way during LBNP. From our findings, echocardiography as a non-invasive procedure can reliably used in LBNP and orthostatic stress tests. Some information can be obtained on borderline values indicating collapse or orthostatic syncope. Early fainters can be differentiated from late fainters by stroke volume changes.
authors.affiliation: Med. Dept., Div. Cardiol., Univ. of Bochum.
authors.forename: H
authors.initials: H
authors.lastname: Lollgen
authors.forename: P
authors.initials: P
authors.lastname: Dirschedl
authors.forename: K
authors.initials: K
authors.lastname: Koppenhagen
authors.forename: K E
authors.initials: KE
authors.lastname: Klein
mesh_terms: D006328:Cardiac Catheterization / Q000379:methods; D004087:Dihydroergotamine / Q000494:pharmacology; D004452:Echocardiography / Q000379:methods; D006321:Heart / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D008150:Lower Body Negative Pressure / Q000009:adverse effects*; D013318:Stroke Volume / Q000502:physiology; D019462:Syncope, Vasovagal / Q000209:etiology / Q000503:physiopathology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D016277:Ventricular Function, Left / Q000502:physiology; D018544:Weightlessness Countermeasures
chemical_list: D014662:Vasoconstrictor Agents; D004087:Dihydroergotamine