Anti-HIV activity of novel phosphonate derivatives of AZT, d4T, and ddA.
Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was 2',3'-Dideoxy-2',3'-didehydrothymidine 5'-isopropylphosphite and among the AZT phosphonate derivatives highest activity was shown by 2',3'-Dideoxy-3'-azidothymidine 5'-cyclohexylphosphite.
Pokrovsky
A G
AG
SRC Virology and Biotechnology Vector, Koltsovo, Russia, 630059.
Pronayeva
T R
TR
Fedyuk
N V
NV
Shirokova
E A
EA
Khandazhinskaya
A L
AL
Tarusova
N B
NB
Karpenko
I L
IL
Krayevsky
A A
AA
D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D016048:Dideoxyadenosine / Q000031:analogs & derivatives; D015224:Dideoxynucleosides / Q000494:pharmacology* / Q000633:toxicity; D016655:HIV Core Protein p24 / Q000032:analysis; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007124:Immunoenzyme Techniques; D063065:Organophosphonates / Q000494:pharmacology / Q000633:toxicity; D018119:Stavudine / Q000031:analogs & derivatives; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000031:analogs & derivatives
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D016655:HIV Core Protein p24; D063065:Organophosphonates; D015215:Zidovudine; D016048:Dideoxyadenosine; D018119:Stavudine