Increased RNA affinity of HNA analogues by introducing alkoxy substituents at the C-1 or C-3 position.
1,5-Anhydrohexitol nucleoside congeners with alkoxy substituents, were prepared, resulting in a further improvement of their RNA affinity and antisense potential.
Van Aerschot
A
A
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.
Meldgaard
M
M
Volders
F
F
Schepers
G
G
Rozenski
J
J
Herdewijn
P
P
D007700:Kinetics; D009705:Nucleosides / Q000138:chemical synthesis* / Q000378:metabolism; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000378:metabolism; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013402:Sugar Alcohols / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
D009705:Nucleosides; D016376:Oligonucleotides, Antisense; D013402:Sugar Alcohols; D012313:RNA