Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective varicella-zoster virus inhibitors.
The discovery of potent and selective inhibitors of VZV based on unusual bicyclic alkyl furo pyrimidine nucleosides has been recently reported. Modifications to the side-chain by addition of a phenyl group were found to further enhance the antiviral potency of these compounds. A series of alkoxyphenyl compounds (5a-5g) and two halophenyl derivatives (5h and 5i) were successfully synthesised and displayed anti-VZV activity at low microM concentrations.
Blewett
S
S
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, Cf10 3XF, United Kingdom.
McGuigan
C
C
Barucki
H
H
Andrei
G
G
Snoeck
R
R
De Clercq
E
E
Balzarini
J
J
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology*
D000998:Antiviral Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011741:Pyrimidine Nucleosides