Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice.
This study was designed to investigate the effects of cocaine-amphetamine-regulated transcript (CART), a recently discovered hypothalamic neuropeptide, on food intake, anxiety, oxygen consumption and gastric emptying in mice. Intracerebroventricular (i. c. v.) injection of CART (1 - 100 pmol) markedly reduced food intake in a dose-related manner. A significant decrease was observed 20 min after i. c. v. injection of CART and continued for four hours. In the elevated plus maze test, i. c. v. CART injection significantly raised the normal preference for the closed arms. Furthermore, the i. c. v. injection of CART significantly reduced oxygen consumption and gastric emptying rate. These results suggest that CART modulates feeding, emotion, and autonomic functions in mice.
Asakawa
A
A
Second Department of Internal Medicine, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Inui
A
A
Yuzuriha
H
H
Nagata
T
T
Kaga
T
T
Ueno
N
N
Fujino
M A
MA
Kasuga
M
M
D000818:Animals; D001007:Anxiety; D004435:Eating / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005746:Gastric Emptying / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein