Preparation of 99mTcN(CBDTC)2 and its biodistribution in mice.
In order to seek a new class of brain perfusion imaging agent containing [99mTcN]2+ core, bis(N-cyclobutyl dithiocarbamato) nitrido technetium-99m complex [99mTcN(CBDTC)2] (CBDTC: N-cyclobutyl dithiocarbamato) was synthesized through a simple and efficient method, which can be utilized for the preparation of a radiopharmaceutical through a lyophilized kit formulation. The radiochemical purity of the complex was over 90%, as measured by thin layer chromatography. No decomposition of the complex at room temperature was observed over a period of 6 h. It's partition coefficient indicated that it is a good lipophilic complex. Biodistribution in mice showed that the complex was significantly retained in the brain. The brain uptake (ID %/g) was 3.61, 3.15 and 2.62 and the brain/blood ratio was 1.00, 1.44 and 1.30 at 5, 30 and 60 min post-injection, respectively. These results suggest that this compound could be a potential brain perfusion imaging agent.
Zhang
J
J
Department of Chemistry, Beijing Normal University, People's Republic of China. zhjunbo0515@sina.com
Wang
X
X
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000000981:diagnostic imaging; D051379:Mice; D015609:Organotechnetium Compounds / Q000302:isolation & purification* / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000302:isolation & purification / Q000493:pharmacokinetics; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals