Nitric oxide: implications for vascular and endovascular surgery.
Nitric oxide has a key role in vascular homeostasis. It plays a protective role by suppressing abnormal proliferation of vascular smooth muscle following various pathological situations including atherosclerosis and restenosis after vascular interventions such as balloon angioplasty, stent deployment and bypass grafting. It also has strong antiplatelet and anti-thrombogenic properties. In this review, possible applications to daily vascular and endovascular surgery practice, including systemic use of NO donors, enhancing endogenous production of NO by L-arginine and gene therapy, local delivery strategies and coating stents and grafts with NO-delivering/enhancing chemicals are reviewed.
Vural
K M
KM
Department of Surgery, Yüksek Ihtisas Hospital of Turkey, Ankara, Turkey.
Bayazit
M
M
D000800:Angioplasty, Balloon; D000818:Animals; D001807:Blood Vessel Prosthesis; D002455:Cell Division / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000627:therapeutic use; D012008:Recurrence; D015607:Stents; D013927:Thrombosis / Q000517:prevention & control / Q000628:therapy; D014652:Vascular Diseases / Q000503:physiopathology / Q000601:surgery*; D014666:Vasomotor System / Q000502:physiology
D020030:Nitric Oxide Donors; D009569:Nitric Oxide