Synthesis of new classes of boron-containing nucleotides.
Four different types of boron-modified nucleotides are reported: P-boranophosphorothioates, P-cyanoboranophosphates, P-boranomethylphosphonates, and P3'-N5'-boranophosphoramidates. Synthesis of dinucleoside borano-phosphorothioates and nucleoside P-borano-P-thiomonophosphates via a lithium sulfide method is described. The Li2S method also provides an alternative way to synthesize phosphorothioates through a dinitrophenyl P(V) phosphotriester precursor. The mechanism of Li2S substitution was investigated.
Lin
J
J
Paul M. Gross Chemical Laboratory, Department of Chemistry, Duke University, Durham, North Carolina 27708-0346, USA.
Shaw
B R
BR
D001896:Boron Compounds / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009711:Nucleotides / Q000138:chemical synthesis*; D063065:Organophosphonates / Q000138:chemical synthesis; D013873:Thionucleotides / Q000138:chemical synthesis
D001896:Boron Compounds; D009711:Nucleotides; D063065:Organophosphonates; D013873:Thionucleotides