title: Gravity-dependent phenomena at the scale of the single cell.
abstract: Progress in gravitational cell biology research will depend on the continuing evaluation of a wide variety of physical phenomena affected by gravity and their roles in extracellular, intercellular, and intracellular processes.  This paper examines those responses of organisms to gravity which depend on functions at the single cell level.  Single cell functions are affected by perturbations in their internal and external environment by a variety of factors, one of which is the effect of gravity.  Physical phenomena that could influence cell function include sedimentation, buoyancy-driven convection, streaming potential, hydrostatic pressure, and interactions among physical transport processes.  Thermal motion and fluid viscosity play a significant role in all transport processes at the cellular level.  The sedimentation of intracellular organelles tends to be counteracted by the cytoskeleton.  Intracellular convective transport may be possible in large cells.  In a microgravity environment extracellular solutes must be transported by diffusion or active circulatory processes in the absence of density gradient-driven convection, and flocculation and coalescence are reduced by the lack of motion of aggregates.
authors.affiliation: Chemical Engineering Science Division, National Institute of Standards and Technology, Boulder, CO 80303, USA.
authors.forename: P
authors.initials: P
authors.lastname: Todd
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002468:Cell Physiological Phenomena; D002477:Cells / Q000648:ultrastructure; D002478:Cells, Cultured; D006224:Cricetinae; D003593:Cytoplasm / Q000502:physiology / Q000648:ultrastructure; D003595:Cytoplasmic Streaming; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D006112:Gravitation; D006801:Humans; D015388:Organelles / Q000502:physiology* / Q000648:ultrastructure; D013026:Space Flight; D014893:Weightlessness