title: Primary intrathoracic meningioma: histopathological, immunohistochemical and ultrastructural study of two cases.
abstract: Meningiomas are common, usually benign slow-growing neoplasms of the central nervous system thought to arise from meningocytes capping arachnoid villi. Primary ectopic meningiomas are exceedingly rare extracranial and extraspinal tumors of controversial origin; they are usually limited to the head and neck region or to the paravertebral soft tissues. Only one mediastinal ectopic meningioma and few pulmonary ectopic meningiomas have been described in the literature until now. Because of their rarity and their intriguing pathogenesis, we report here a second case of primary mediastinal meningioma and an additional case of primary pulmonary meningioma. Their possible origin and differential diagnosis are discussed.
authors.affiliation: Department of Pathology, School of Medicine, University of Milan, San Paolo Hospital, Italy. monica.falleni@unimi.it
authors.forename: M
authors.initials: M
authors.lastname: Falleni
authors.forename: E
authors.initials: E
authors.lastname: Roz
authors.forename: E
authors.initials: E
authors.lastname: Dessy
authors.forename: B
authors.initials: B
authors.lastname: Del Curto
authors.forename: P
authors.initials: P
authors.lastname: Braidotti
authors.forename: U
authors.initials: U
authors.lastname: Gianelli
authors.forename: G G
authors.initials: GG
authors.lastname: Pietra
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D008479:Mediastinal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008545:Melanoma / Q000175:diagnosis / Q000556:secondary; D008579:Meningioma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor