Cerebral blood flow velocity and cranial fluid volume decrease during +Gz acceleration.
Cerebral blood flow (CBF) velocity and cranial fluid volume, which is defined as the total volume of intra- and extracranial fluid, were measured using transcranial Doppler ultrasonography and rheoencephalography, respectively, in humans during graded increase of +Gz acceleration (onset rate: 0.1 G/s) without straining maneuvers. Gz acceleration was terminated when subjects' vision decreased to an angle of less than or equal to 60 degrees, which was defined as the physiological end point. In five subjects, mean CBF velocity decreased 48% from a baseline value of 59.4 +/- 11.2 cm/s to 31.0 +/- 5.6 cm/s (p<0.01) with initial loss of peripheral vision at 5.7 +/- 0.9 Gz. On the other hand, systolic CBF velocity did not change significantly during increasing +Gz acceleration. Cranial impedance, which is proportional to loss of cranial fluid volume, increased by 2.0 +/- 0.8% above the baseline value at the physiological end point (p<0.05). Both the decrease of CBF velocity and the increase of cranial impedance correlated significantly with Gz. These results suggest that +Gz acceleration without straining maneuvers decreases CBF velocity to half normal and probably causes a caudal fluid shift from both intra- and extracranial tissues.
Kawai
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NASA Ames Research Center, Gravitational Research Branch, Moffett Field, CA 94035-1000, USA.
Puma
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SC
Hargens
A R
AR
Murthy
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G
Warkander
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D
Lundgren
C E
CE
D000054:Acceleration; D000328:Adult; D000337:Aerospace Medicine; D001783:Blood Flow Velocity / Q000502:physiology; D002498:Centrifugation; D002555:Cerebrospinal Fluid / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D018471:Hypergravity; D008297:Male; D008875:Middle Aged; D013575:Syncope / Q000209:etiology; D017585:Ultrasonography, Doppler, Transcranial