Growth hormone and prolactin secretion after metoclopramide administration (DA2 receptor blockade) in fertile women.
In this report, we will describe the results of a cross-sectional study to assess PRL and GH secretion during the early follicular phase in 22 fertile patients after metoclopramide administration in order to achieve a dopaminergic DA2 receptor blockade. Blood samples were collected at - 15, 0, 15, 30, 45 and 60 minutes. PRL, GH, estradiol, IGF-I, TSH, glucose, and insulin were measured in the samples taken at - 15 and 0 minutes. The existence of a correlation between GH and PRL secretion was investigated. All patients presented normal serum levels of estradiol, prolactin, insulin, fasting glucose and IGF-I. Serum GH levels were not changed after metoclopramide infusion (p = 0.302), but there was a significant alteration in serum PRL (p = 0.0001) with the highest levels after 30 (mean: 237.20 ng/ml +/- 95.86) and 45 (mean: 211.80 ng/ml +/- 83.24) minutes. Serum GH levels did not correlate with serum PRL levels after the dopaminergic DA2 blockade. We conclude that GH secretion was not modulated by a direct effect of type 2 dopamine receptor.
Cunha-Filho
J S
JS
Obstetrics and Gynecology Department, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil.
Gross
J L
JL
Vettori
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D
Dias
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EC
Passos
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D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D065127:Dopamine D2 Receptor Antagonists; D004958:Estradiol / Q000097:blood; D005260:Female; D005298:Fertility; D019382:Human Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007700:Kinetics; D008787:Metoclopramide / Q000494:pharmacology*; D009765:Obesity / Q000097:blood; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood
D001786:Blood Glucose; D065127:Dopamine D2 Receptor Antagonists; D007328:Insulin; D019382:Human Growth Hormone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D013972:Thyrotropin; D008787:Metoclopramide