[Modulation of behavior of mice of different genotypes by serotonin antibodies].
The effect of active immunization with conjugated serotonin-protein on the "open-field" behaviour and passive avoidance conditioning was studied in genetically different mice strains (C57BL/6 and BALB/c). The obtained immunophysiological effects of serotonin antibodies depended on genetically determined characteristics of animal behaviour. Serotonin antibodies altered rearing and crossings of the "open-field" center and retention of passive avoidance learning in C57BL/6 mice. The active immunization with conjugated serotonin-protein of BALB/c mice resulted in modulation of the "open-field" latency and both training and testing of passive avoidance behaviour.
Mikovskaia
O I
OI
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Vetrilé
L A
LA
Trekova
N A
NA
Basharova
L A
LA
Evseev
V A
VA
D000818:Animals; D000906:Antibodies / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D014644:Genetic Variation; D007114:Immunization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012701:Serotonin / Q000276:immunology* / Q000502:physiology; D013045:Species Specificity
D000906:Antibodies; D012701:Serotonin