title: The efficacy of a protective cream in a real-world apprentice hairdresser environment.
abstract: The object of this study was to compare the protective action of a new barrier cream (Excipial Protect, Spirig Pharma AG, Egerkingen, Switzerland) to its vehicle in the context of hand irritation of apprentice hairdressers caused by repeated shampooing and exposure to hair-care products. This was a double-blind cross-over comparing Excipial Protect (containing aluminium chlorohydrate 5% as active ingredient) against its vehicle alone. The efficacy of the creams was evaluated taking into account: (1) clinical scores by researchers, (2) biometric measurements, (3) subjective opinions of the subjects. An analysis of variance was performed considering order of application, degree of atopy, and reported number of shampoos. We observed very little difference in efficacy between the protective cream and its vehicle. The presence, however, of aluminium chlorhydrate in the protective cream was shown to have a positive effect against work-related irritation. The cosmetic qualities of the creams seemed, to the participants, to be as important as their real protective and hydrating properties, an important factor in compliance issues.
authors.affiliation: Department of Dermatology (DHURDV), University Hospitals, Geneva & Lausanne, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Perrenoud
authors.forename: D
authors.initials: D
authors.lastname: Gallezot
authors.forename: G
authors.initials: G
authors.lastname: van Melle
mesh_terms: D018592:Cross-Over Studies; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000517:prevention & control*; D009783:Dermatitis, Occupational / Q000209:etiology / Q000517:prevention & control*; D003879:Dermatologic Agents / Q000627:therapeutic use; D004311:Double-Blind Method; D004643:Emollients / Q000627:therapeutic use*; D006203:Hair Preparations / Q000009:adverse effects*; D006801:Humans; D012867:Skin / Q000187:drug effects / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D004643:Emollients; D006203:Hair Preparations