Physical performance and skeletal muscle characteristics after 2-week hind-limb unweighting.
It is well-known that 2 weeks of hind-limb suspension or space flight induce the sufficient decrease of the physical performance and simultaneously changes of muscle contractile properties and fiber size. However, the data on enzyme activities changes at present are contradictory. Numerous authors have pointed to the increase, reduction of its activity as well as its stability after experiments of the similar design. In previous studies it was shown that beta-GPA (beta-guanidino-propionic acid) administration increased the oxidative enzyme activities in the skeletal muscles and improved their contractile properties in hind-limb suspended rats. The aim of our study is to clear out what determines changes of the physical performance after 2 weeks of hind-limb suspension and beta-GPA administration.
Nemirovskaya
T
T
Institute of Biomedical Problems, Moscow, Russia.
Shenkman
B
B
Nasledov
G
G
Arutyunyan
R
R
D000818:Animals; D003576:Electron Transport Complex IV / Q000187:drug effects / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D019417:Hindlimb Suspension; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D018656:Muscle Fibers, Fast-Twitch / Q000187:drug effects*; D018657:Muscle Fibers, Slow-Twitch / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D009246:NADH Tetrazolium Reductase / Q000187:drug effects / Q000378:metabolism; D005082:Physical Exertion / Q000502:physiology*; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000187:drug effects / Q000378:metabolism
D006146:Guanidines; D011422:Propionates; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D009246:NADH Tetrazolium Reductase; D003576:Electron Transport Complex IV; C005775:guanidinopropionic acid