title: Rapid response of severe refractory metastatic Crohn's disease to infliximab.
abstract: A case is described of a middle-aged female who developed an aggressive form of biopsy-proven metastatic Crohn's disease involving the inguinal, perineal and submammary areas. Her condition had been unresponsive to topical and systemic corticosteroids, antibiotics, immunosuppressives, and repeated surgical debridement. Administration of infliximab resulted in a rapid clinical response with subjective improvements in pain and general well-being, and an objective decline in exudate, erythema and size of the lesions. Infliximab may be a suitable therapeutic option in patients with metastatic Crohn's disease.
authors.affiliation: Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia. milleram@svhm.org.au
authors.forename: A M
authors.initials: AM
authors.lastname: Miller
authors.forename: P R
authors.initials: PR
authors.lastname: Elliott
authors.forename: R
authors.initials: R
authors.lastname: Fink
authors.forename: W
authors.initials: W
authors.lastname: Connell
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab