Comparison of once-daily versus twice-daily administration of cefdinir against typical bacterial respiratory tract pathogens.
In an in vitro pharmacodynamic model, a twice-daily cefdinir dosing regimen was more effective than a once-daily regimen against common bacterial respiratory pathogens in producing 3-log(10) killing and preventing the occurrence of regrowth at 24 h. Twice-daily administration is likely the more appropriate cefdinir dosing strategy for the treatment of community-acquired pneumonia.
Ross
G H
GH
College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Hovde
L B
LB
Ibrahim
K H
KH
Ibrahim
Y H
YH
Rotschafer
J C
JC
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000077525:Cefdinir; D002511:Cephalosporins / Q000008:administration & dosage* / Q000494:pharmacology; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D012141:Respiratory Tract Infections / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077525:Cefdinir