title: Abnormal ACTH-stimulation test in a patient with AIDS: adrenal insufficiency or toxoplasmosis?
abstract: We here report a 32-year old homosexual man with AIDS who had an abnormal ACTH stimulation test while taking megestrol actetate (megace). On further evaluation, he was found to have recurrent Non-Hodgkin lymphoma (spleen) and intracranial toxoplasmosis, perhaps imitating or aggravating symptoms suggestive of adrenal insufficiency (AI). We diagnosed secondary AI due to megace treatment and tapered this medication under simultaneous hydrocortisone replacement therapy. After the patient's intracranial toxoplasmosis had been treated with intravenous bactrim, his symptoms disappeared. We conclude that patients with AIDS on megace therapy should receive special attention in regards to the potential development of AI, especially in stress situations such as infections or pain.
authors.affiliation: Pediatric and Reproductive Endocrinology Branch, National Institute of Child Helath and Human Development, National Intitutes of Health, Bethesda, MD 20892, USA. kochc@exchange.nih.gov
authors.forename: C A
authors.initials: CA
authors.lastname: Koch
authors.forename: K
authors.initials: K
authors.lastname: Pacak
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D000309:Adrenal Insufficiency / Q000139:chemically induced / Q000175:diagnosis*; D000324:Adrenocorticotropic Hormone; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D019290:Megestrol Acetate / Q000037:antagonists & inhibitors; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis* / Q000188:drug therapy; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000324:Adrenocorticotropic Hormone; D019290:Megestrol Acetate