[Hypolipidemic and antioxidant effects of pyridyl-3-glyoxylic acid].
Pyridyl-3-glyoxylic acid reduced the blood cholesterol and triglycerides, normalized the lipoprotein spectrum, markedly decreased the intensity of lipid peroxidation, and increased the superoxide dismutase enzyme activity in the experimental rabbits with cholesterol atherosclerosis model. The efficacy of the compound exceeded that of nicotinic acid used as the reference compound.
Sadykova
Kh U
KhU
Department of Propedeutics of Internal Disorders, First State Medical Institute, ul. Khamzy 103, Tashkent, 700047 Uzbekistan.
Abdullaev
A Kh
AKh
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D001161:Arteriosclerosis / Q000139:chemically induced / Q000188:drug therapy*; D002784:Cholesterol / Q000032:analysis; D006038:Glyoxylates / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D000960:Hypolipidemic Agents / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008074:Lipoproteins / Q000032:analysis / Q000737:chemistry; D008315:Malondialdehyde / Q000032:analysis; D011725:Pyridines / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D013482:Superoxide Dismutase / Q000032:analysis; D023382:Toxicity Tests, Acute; D014280:Triglycerides / Q000032:analysis
D000975:Antioxidants; D006038:Glyoxylates; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D011725:Pyridines; D014280:Triglycerides; C435525:pyridine-3-glyoxylic acid; D008315:Malondialdehyde; D002784:Cholesterol; D013482:Superoxide Dismutase