title: Review of primary spaceflight-induced and secondary reloading-induced changes in slow antigravity muscles of rats.
abstract: We have examined the light and electron microscopic properties of hindlimb muscles of rats flown in space for 1-2 weeks on Cosmos biosatellite flights 1887 and 2044 and Space Shuttle missions Spacelab-3, Spacelab Life Sciences-1 and Spacelab Life Sciences-2. Tissues were obtained both inflight and postflight permitting definition of primary microgravity-induced changes and secondary reentry and gravity reloading-induced alterations.  Spaceflight causes atrophy and expression of fast fiber characteristics in slow antigravity muscles. The stresses of reentry and reloading reveal that atrophic muscles show increased susceptibility to interstitial edema and ischemic-anoxic necrosis as well as muscle fiber tearing with disruption of contractile proteins. These results demonstrate that the effects of spaceflight on skeletal muscle are multifaceted, and major changes occur both inflight and following return to Earth's gravity.
authors.affiliation: Department of Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee 53226, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Riley
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D018485:Muscle Fibers, Skeletal / Q000473:pathology* / Q000648:ultrastructure; D018908:Muscle Weakness / Q000209:etiology; D018482:Muscle, Skeletal / Q000473:pathology* / Q000648:ultrastructure; D009133:Muscular Atrophy / Q000209:etiology* / Q000473:pathology; D051381:Rats; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*