[Modulation by ultralow intensity electromagnetic fields on pharmacologic effects of psychotropic drugs].
The ultralow-intensity electromagnetic fields (EMF, frequency of 4200, modulated by a quasistochastic signal in the range of 20-20,000 Hz, power density of 15 microW/cm2, specific body absorption rate up to 4.5 mJ/kg) potentiated the hypnogenic effect of hexenal. The exposure to the EMF shortened the time of falling asleep induced by this drug and increased sleep duration in rats. The exposure to the EMF also potentiated haloperidol catalepsy: it decreased the drug threshold dose and increased the catalepsy duration. The EMF influence on the haloperidol effects was of a prolonged character: it was manifest in a selected suppression of the emotional excitation in the open-field test within 24 hours after the exposure.
Shtemberg
A S
AS
National Research Center Institute of Medical and Biological Problems, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Research Institute of Psychiatry, Russian Ministry of Public Health, Moscow.
Bazian
A S
AS
Shikhov
S N
SN
Cherniakov
G M
GM
Uzbekov
M G
MG
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000528:radiation effects; D002375:Catalepsy / Q000139:chemically induced; D004574:Electromagnetic Fields; D006220:Haloperidol / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects / Q000528:radiation effects
D011619:Psychotropic Drugs; D006591:Hexobarbital; D006220:Haloperidol