GABA signalling during development: new data and old questions.
In addition to being the major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) is thought to play a morphogenetic role in embryonic development. During the last decade, considerable progress has been made in elucidating the molecular mechanisms involved in GABA synthesis and biological action. The present review is an attempt to summarise recent results on the ontogeny of the different components of embryonic GABA signalling with an emphasis on the synthesis of GABA by different molecular forms of glutamic acid decarboxylase (GAD).
Varju
P
P
Laboratory of Neural Cell Biology, Institute of Experimental Medicine, Budapest, Hungary.
Katarova
Z
Z
Madarász
E
E
Szabó
G
G
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism / Q000502:physiology; D050485:GABA Plasma Membrane Transport Proteins; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism*; D020439:Growth Cones / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D026901:Membrane Transport Proteins; D016296:Mutagenesis; D009474:Neurons / Q000166:cytology / Q000502:physiology; D027361:Organic Anion Transporters; D015398:Signal Transduction / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology
D002352:Carrier Proteins; D050485:GABA Plasma Membrane Transport Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D027361:Organic Anion Transporters; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase