title: Terminal latency index in polyneuropathy with IgM paraproteinemia and anti-MAG antibody.
abstract: Criteria for the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) are met by the polyneuropathy associated with immunoglobulin M (IgM) paraproteinemia and anti-myelin-associated glycoprotein (MAG) antibody (MAG-CIDP). However, MAG-CIDP differs from other types of CIDP, mainly in its poorer response to treatment. The utility of terminal latency index (TLI) as an electrophysiological marker for MAG-CIDP has been debated. In this study we confirmed its diagnostic usefulness and evaluated TLI threshold values for motor nerves investigated in routine nerve conduction studies. Median, ulnar, peroneal, and tibial TLIs of 11 subjects with MAG-CIDP, 18 with CIDP, and 76 healthy controls were compared, and threshold values for MAG-CIDP evaluated as the lowest value with a likelihood ratio higher than 10. Mean TLI values and TLIs of all but the peroneal nerve were significantly lower in MAG-CIDP. Median nerve TLI of 0.26 and ulnar nerve TLI of 0.33 were identified as the threshold TLI values for MAG-CIDP.
authors.affiliation: Unità Operativa di Neurofisiologia Clinica, Dipartimento di Neuroscienze, Università di Torino, Via Cherasco 15, 10126 Torino, Italy. dariococito@yahoo.it
authors.forename: D
authors.initials: D
authors.lastname: Cocito
authors.forename: G
authors.initials: G
authors.lastname: Isoardo
authors.forename: P
authors.initials: P
authors.lastname: Ciaramitaro
authors.forename: G
authors.initials: G
authors.lastname: Migliaretti
authors.forename: A
authors.initials: A
authors.lastname: Pipieri
authors.forename: P
authors.initials: P
authors.lastname: Barbero
authors.forename: A
authors.initials: A
authors.lastname: Cucci
authors.forename: L
authors.initials: L
authors.lastname: Durelli
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D009431:Neural Conduction; D010265:Paraproteinemias / Q000276:immunology / Q000503:physiopathology*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology*; D011930:Reaction Time; D012680:Sensitivity and Specificity; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology / Q000503:physiopathology
chemical_list: D007075:Immunoglobulin M; D018992:Myelin-Associated Glycoprotein