title: Treatment of chronic rhinosinusitis refractory to other treatments with topical antibiotic therapy delivered by means of a large-particle nebulizer: results of a controlled trial.
abstract: OBJECTIVE
  To study the efficacy of nebulized topical saline-tobramycin solution in patients with chronic rhinosinusitis refractory to medical and surgical therapy.
  
  
  METHODS
  Twenty patients in whom endoscopic sinus surgery failed to relieve symptoms entered a randomized, double-blind trial of tobramycin-saline solution or saline-only solution administered thrice daily to the nasal passages by means of a large-particle nebulizer apparatus for 4 weeks, followed by a 4-week observation period. Outcome measures of symptoms, quality of life, and endoscopic aspect of sinus mucosa were assessed.
  
  
  RESULTS
  Both treatments were well tolerated and produced equivalent improvement in symptoms, quality of life, and mucosal aspect. Treatment with the tobramycin-saline solution gave more rapid improvement of pain, but led to the development of nasal congestion.
  
  
  CONCLUSIONS
  Therapy with a 4-week course of large-particle nebulized aerosol therapy improves symptomatology and objective parameters of rhinosinusitis in patients refractory to surgical and medical therapies. Addition of tobramycin appears of minimal benefit. The mechanism of this effect is unexplained.
  
  
  CONCLUSIONS
  Large-particle nebulized aerosol therapy may offer a safe and effective management alternative for patients with refractory rhinosinusitis.
authors.affiliation: Department of Otolaryngology and Allergy, The Montreal General Hospital, McGill University Health Center, Quebec, Canada. Nosedoc@total.net
authors.forename: M Y
authors.initials: MY
authors.lastname: Desrosiers
authors.forename: M
authors.initials: M
authors.lastname: Salas-Prato
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000336:Aerosols; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000601:surgery; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life; D012220:Rhinitis / Q000188:drug therapy* / Q000601:surgery; D012462:Saline Solution, Hypertonic; D012852:Sinusitis / Q000188:drug therapy* / Q000601:surgery; D014031:Tobramycin / Q000008:administration & dosage*; D017211:Treatment Failure
chemical_list: D000336:Aerosols; D000900:Anti-Bacterial Agents; D012462:Saline Solution, Hypertonic; D014031:Tobramycin