title: Revised interpretation of the immunological results obtained with pneumococcal polysaccharide 17F derived synthetic di-, tri- and tetrasaccharide conjugates in mice and rabbits.
abstract: Recently, the structure for pneumococcal polysaccharide (PS) 17F has been revised. Based on the former PS structure, immunogenicities of PS 17F derived synthetic di-, tri- and tetrasaccharide conjugates have been reported in mice. Here, we present additional data on the immunogenicities of these conjugates in rabbits and re-evaluate the immunogenicity results in the light of the revised PS 17F structure.
authors.affiliation: Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, Vaccines Section, Utrecht University Hospital, 3584 CX, Utrecht, The Netherlands. jwo@gbf.de
authors.forename: W T
authors.initials: WT
authors.lastname: Jansen
authors.forename: A F
authors.initials: AF
authors.lastname: Verheul
authors.forename: G H
authors.initials: GH
authors.lastname: Veeneman
authors.forename: J H
authors.initials: JH
authors.lastname: van Boom
authors.forename: H
authors.initials: H
authors.lastname: Snippe
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology; D002240:Carbohydrate Sequence; D007115:Immunization Schedule; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000276:immunology*; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000276:immunology; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate; D014614:Vaccines, Synthetic; C094780:pneumococcal polysaccharide type 17F