A code relating sequence to structure in nucleic acids.
Nucleic acids are elucidated in configuration space. An algorithm relating sequence to stability in A and B helical secondary structures, is stated to incorporate NMR conformational and optical melting data. This made possible a classification of elementary sequences in terms of configuration forces driving between A and B states, a finding useful in prediction of structural behavior of different sequences of DNA, RNA and their hybrids.
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Division of Biophysics, Institute of Experimental Physics, Department of Physics, University of Warsaw, al. Zwirki i Wigury 93, Warszawa, PL 02-089, Poland.
D000465:Algorithms; D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D019143:Evolution, Molecular; D008956:Models, Chemical; D019906:Nuclear Magnetic Resonance, Biomolecular; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000235:genetics; D013816:Thermodynamics
D012313:RNA; D004247:DNA