title: Changes in muscle sympathetic nerve activity and effects of breathing maneuvers in humans during microgravity induced by parabolic flight.
abstract: The mechanism of cardiovascular deconditioning, such as an orthostatic intolerance after space flight, has not been well clarified. Several studies to investigate that mechanism have focused mainly on hemodynamic changes including heart rate, arterial blood pressure, cardiac output, etc., but no studies have yielded a  direct insight into changes in the sympathetic nervous system. Among ground-based experiments, parabolic flight is the only maneuver to expose human subjects to actual microgravity although it lasts for only a short duration of approx. 20 sec. Using microneurography, the present study aimed to analyze the involvement of the sympathetic nervous system in regulating the acute effects of fluid shift induced by parabolic flight during the transitional changes from 1 G to hypergravity, hypergravity to microgravity, and microgravity to hypergravity by direct measurement of sympathetic outflow to the muscles. Some parts of the study were published elsewhere. We also investigated how the sympathetic outflow to muscle is modified during microgravity with elimination of the breathing effect by comparing the cardiovascular parameters under controlled and uncontrolled respiration.
authors.affiliation: Department of Autonomic Neuroscience, Nagoya University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iwase
authors.forename: C
authors.initials: C
authors.lastname: Jian
authors.forename: H
authors.initials: H
authors.lastname: Kitazawa
authors.forename: A
authors.initials: A
authors.lastname: Kamiya
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: C
authors.initials: C
authors.lastname: Mukai
authors.forename: M
authors.initials: M
authors.lastname: Kohno
authors.forename: T
authors.initials: T
authors.lastname: Mano
authors.forename: S
authors.initials: S
authors.lastname: Nagaoka
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D018493:Cardiovascular Deconditioning; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D018471:Hypergravity; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology*; D012119:Respiration; D013026:Space Flight; D013564:Sympathetic Nervous System / Q000502:physiology*; D014893:Weightlessness