title: Obstructive sleep apnea syndrome in a patient with medulloblastoma.
abstract: We present one adult patient with medulloblastoma who developed polysomnographically documented obstructive sleep apnea after posterior fossa surgery. The sleep apnea worsened in conjunction with clinical and imaging-confirmed neoplastic progression and clinically improved after craniospinal radiation therapy. Medulloblastoma or its surgical treatment has never before been implicated in a sleep-related breathing disorder. We discuss possible mechanisms for its occurrence and management implications.
authors.affiliation: Sleep Disorders Center, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA.
authors.forename: G
authors.initials: G
authors.lastname: Greenough
authors.forename: M
authors.initials: M
authors.lastname: Sateia
authors.forename: C E
authors.initials: CE
authors.lastname: Fadul
mesh_terms: D000328:Adult; D002528:Cerebellar Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000601:surgery; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior; D016371:Cranial Irradiation; D003399:Craniotomy; D003680:Deglutition Disorders / Q000209:etiology; D003907:Dexamethasone / Q000627:therapeutic use; D004322:Drainage; D004401:Dysarthria / Q000209:etiology; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D011175:Positive-Pressure Respiration; D011183:Postoperative Complications; D018714:Radiotherapy, Adjuvant; D020181:Sleep Apnea, Obstructive / Q000209:etiology* / Q000628:therapy; D014139:Tracheostomy
chemical_list: D003907:Dexamethasone