title: Mineralization of human bone tissue under hypokinesia and physical exercise with calcium supplements.
abstract: It has been suggested that physical exercise and calcium supplements may be used to prevent demineralization of bone tissue under hypokinesia (diminished muscular activity). Thus, the aim of this study was to determine mineral content of bones of 12 physically healthy men aged 19-24 years under 90 days of hypokinesia and intensive physical exercise (PE) with calcium lactate (C) supplements. They were divided into experimental and control groups with 6 men in each. The experimental group of men were subjected to hypokinesia (HK) and intensive PE and took 650 mg C 6 times per day; the control group was placed under pure HK, i.e. without the use of any preventive measures. The mineral content of different bone tissues was measured with a densitometric X-ray method in milligrams of calcium per 1 mm3 before and after exposure to HK. The level of bone density of the examined bone tissues decreased by 7-9% and 5-7% for the control and experimental groups of men, respectively. A statistical analysis revealed that the reduction of bone mineralization was significant with P < 0.01 in both groups of men. A comparison between bone density changes in the control and experimental groups of men failed to demonstrate significant differences. It was concluded that the level of mineralization of bone tissues decreased under hypokinesia and physical exercise with calcium supplements.
authors.affiliation: Danielopolu Institute of Physiology, Bucharest, Rumania.
authors.forename: Y G
authors.initials: YG
authors.lastname: Zorbas
authors.forename: G E
authors.initials: GE
authors.lastname: Verentsov
authors.forename: N I
authors.initials: NI
authors.lastname: Abratov
mesh_terms: D000328:Adult; D001510:Bed Rest; D001835:Body Weight; D018488:Bone Demineralization, Pathologic / Q000517:prevention & control*; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism / Q000627:therapeutic use*; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy; D006801:Humans; D007866:Leg; D008297:Male
chemical_list: D002118:Calcium