title: Synthesis of 2',3'-dideoxy-2',3'-didehydro nucleosides via a serendipitous route.
abstract: This paper describes a "green" synthesis of 2',3'-unsaturated 2',3'-dideoxynucleosides via an electrochemical reaction. Using this approach d4T, d4U, ddA and ddI can be synthesized in high yields.
authors.affiliation: Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, California 92008, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Guo
authors.forename: Y S
authors.initials: YS
authors.lastname: Sanghvi
authors.forename: L E
authors.initials: LE
authors.lastname: Brammer
authors.forename: T
authors.initials: T
authors.lastname: Hudlicky
mesh_terms: D015224:Dideoxynucleosides / Q000138:chemical synthesis*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013936:Thymidine / Q000138:chemical synthesis
chemical_list: D015224:Dideoxynucleosides; D011741:Pyrimidine Nucleosides; D013936:Thymidine