Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.
The increase in drug-resistant pathogenic bacteria has created an urgent demand for new antibiotics. Among the more attractive targets for the development of new antibacterial compounds are the enzymes of fatty acid biosynthesis. Although a number of potent inhibitors of microbial fatty acid biosynthesis have been discovered, few of these are clinically useful drugs. Several of these fatty acid biosynthesis inhibitors have potential as lead compounds in the development of new antibacterials. This review encompasses the known inhibitors and prospective targets for new antibacterials.
Campbell
J W
JW
Department of Microbiology University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Cronan
J E
JE
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D016503:Drug Delivery Systems; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005227:Fatty Acids / Q000096:biosynthesis*; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D005227:Fatty Acids