Convenient method for the preparation of 2'-deoxyribosylurea by thymidine oxidation and NMR study of both anomers.
The synthesis of 2'-deoxyribosylurea by thymidine oxidation with potassium permanganate followed by alkaline hydrolysis of intermediates is described. The anomeric configuration of the resulting products was studied by NMR spectroscopy.
Dubey
I
I
Laboratoire de Chimie de Coordination du CNRS, Toulouse, France.
Pratviel
G
G
Robert
A
A
Meunier
B
B
D003855:Deoxyribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D013936:Thymidine / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
D003855:Deoxyribose; D014508:Urea; D013936:Thymidine