[Role of estrogen receptors in apoptosis and mitotic disorders in patients with atrophic gastritis presenting with precancerous changes of the gastric mucosa].
The presence of receptors to estrogens (ER) was studied together with the apoptotic (AI) and mitotic (MI) indices, number of pathological mitoses (PM) in biopsy specimens of gastric mucosa (GM) of patients with atrophic gastritis presenting with epithelial dysplasia (n = 73) and healthy subjects (n = 25), with the aid of radioimmunological and morphological techniques respectively. The patients were also studied for their blood serum concentration of a dissolvable Fas-antigen (sFas), a regulator of apoptosis. It has been ascertained that values of the above indices for apoptosis and mitotic regimen depend on the pressure of GM ER. In ER(+) patients presenting with epithelial dysplasia, AI, sFas, MI and PM are higher than in ER(-) patients, which fact permits reaching the conclusion that ER are involved in the mechanism of gastrocarcinogenesis.
Stepanov
Iu M
IuM
Hrytsenko
I I
II
D017209:Apoptosis; D001706:Biopsy; D015331:Cohort Studies; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008938:Mitosis; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology*; D011960:Receptors, Estrogen / Q000378:metabolism*; D019014:fas Receptor / Q000097:blood / Q000378:metabolism
D011960:Receptors, Estrogen; D019014:fas Receptor