[Dependence of the antioxidant effect of imidazole derivatives on concentration and a method of administration].
An experimental model study of the antioxidant properties of imidazole derivatives showed evidence of a nonlinear dose-effect relationship as manifested by hemiluminescence in liposomes. In the in vivo experiments on a thiophenol intoxication model, the antioxidant effect observed for a "large dose-short time" scheme was more favorable than that for a "small dose-long time" administration schedule.
Pavlova
R N
RN
Department of Biochemistry, Mechnikov State Medical Academy, Piskarevskii pr. 47, St. Petersburg, 195067 Russia.
Kuznetsova
O A
OA
Dadali
V A
VA
Abyshev
A Z
AZ
Sokolova
E A
EA
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005609:Free Radicals / Q000378:metabolism; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D008081:Liposomes; D008163:Luminescent Measurements; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D010636:Phenols / Q000506:poisoning; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000506:poisoning
D000975:Antioxidants; D005609:Free Radicals; D007093:Imidazoles; D008081:Liposomes; D010636:Phenols; D013438:Sulfhydryl Compounds; C042983:thiophenol