title: Is peptic ulcer a common cause of upper gastrointestinal symptoms?
abstract: The aim of the study was to investigate retrospectively a cohort of children with peptic ulcer disease during a period that covers the recent changes in diagnosis and management of the disease. Over a period of 9 years, 2550 children underwent upper gastrointestinal endoscopy for various reasons. All children, in whom a diagnosis of primary peptic ulcer was established, were included in the study. Previous and current medical history, family history, endoscopic and histological outcome were evaluated and the children were regularly followed-up on an out-patient basis. Primary peptic ulcer was diagnosed in 52 (10 gastric and 42 duodenal, 2%) out of 2550 children. The median age of children with gastric ulcer was 6.5 years, whereas of those with duodenal ulcer was 10.5 years (P=0.04). With regard to clinical symptoms no significant difference was found between children with and without ulcer. The prevalence of Helicobacter pylori infection was significantly higher in children with duodenal ulcer (62%) compared to those with gastric ulcer (20%; P < 0.001). At first follow-up visit, 1 month after the end of treatment, 19 symptomatic children underwent a repeat endoscopy, which showed ulcer healing in 95% and failure in H. pylori eradication in 27%. During the long-term follow-up (median 3.5 years), six children became symptomatic. Two of them had duodenal ulcer associated with positive H. pylori.
  
  
  CONCLUSIONS
  Peptic ulcer disease is an uncommon disorder in childhood with non specific clinical features; it seems that efficient treatment and successful Helicobacter pylori eradication result in clinical improvement and cure as well as in long-term healing of ulcers.
authors.affiliation: Department of Paediatric Gastroenterology and Nutrition, Athens University, Aghia Sophia Children's Hospital, Goudi, Greece. roma2el@otenet.gr
authors.forename: E
authors.initials: E
authors.lastname: Roma
authors.forename: Y
authors.initials: Y
authors.lastname: Kafritsa
authors.forename: J
authors.initials: J
authors.lastname: Panayiotou
authors.forename: R
authors.initials: R
authors.lastname: Liakou
authors.forename: A
authors.initials: A
authors.lastname: Constantopoulos
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004381:Duodenal Ulcer / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology