title: Adaptive responses of the cardiovascular system to prolonged spaceflight conditions:  assessment with Holter monitoring.
abstract: This article presents selected findings obtained with Holter monitoring from two crew members of the expedition, performed during a 175-day space mission on board orbital space station "MIR." Using mathematical processing of daily cardiointervals files, 5-minute sections of records were analyzed consecutively. Then, the average daily values of indices, the average-per-every-eight-hours values (morning, evening, night) and mean values per hour were computed. The results of analysis showed that prolonged exposure of man to microgravity conditions leads to important functional alteration in human neuroautonomic regulatory mechanisms. Both crew members had significant increase of heart rate, the rise of stress index, the decrease in power of the spectrum in the range of respiratory sinus arrhythmia. These marked signs of activation of the sympathetic section of the vegetative nervous system showed individual variations. The analysis of the daily collection of cardiointervals with Holter monitoring allows us to understand and forecast the functional feasibilities of the human organism under a variety of stress conditions associated with acute and chronic microgravity exposure.
authors.affiliation: Institute of Biomedical Problems, Moscow, Russia.
authors.forename: R M
authors.initials: RM
authors.lastname: Baevsky
authors.forename: B S
authors.initials: BS
authors.lastname: Bennett
authors.forename: M W
authors.initials: MW
authors.lastname: Bungo
authors.forename: J B
authors.initials: JB
authors.lastname: Charles
authors.forename: A L
authors.initials: AL
authors.lastname: Goldberger
authors.forename: G A
authors.initials: GA
authors.lastname: Nikulina
mesh_terms: D000222:Adaptation, Physiological; D000337:Aerospace Medicine; D001146:Arrhythmia, Sinus / Q000503:physiopathology; D015716:Electrocardiography, Ambulatory; D006339:Heart Rate; D006801:Humans; D008297:Male; D010275:Parasympathetic Nervous System; D013026:Space Flight; D013312:Stress, Physiological; D013564:Sympathetic Nervous System; D013997:Time Factors; D014893:Weightlessness