DNA-photocleavage agents.
This review describes recent advances in the development of DNA-photocleavage agents. Major mechanisms of photosensitized DNA photocleavage are presented and the most popular categories of compounds are considered, which include metal complexes and many organic functional derivatives. DNA-targeted conjugates of photosensitizers are also described and discussed.
Da Ros
T
T
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy. prato@univ.trieste.it
Spalluto
G
G
Boutorine
A S
AS
Bensasson
R V
RV
Prato
M
M
D001483:Base Sequence / Q000187:drug effects; D001665:Binding Sites / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D053938:DNA Fragmentation / Q000187:drug effects; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000378:metabolism* / Q000494:pharmacology*
D017319:Photosensitizing Agents; D004247:DNA