title: A monoclonal antibody specific to a song system nuclear antigen in estrildine finches.
abstract: This paper describes a monoclonal antibody that recognizes a molecule whose expression is mostly restricted to some of the forebrain areas that control singing behavior in adult estrildine species studied, including the zebra, Bengalese, and spice finches. When the song system displays extreme sexual dimorphism, as in these species, antibody staining occurs only in the male's song nuclei. However, protein expression is identical in both sexes of estrildine finches, in which females also have a well-developed song system. Canaries appear to lack the protein, but it can be induced in female zebra finches by early estrogen treatment. Antibody staining patterns in the zebra finch show that the protein's expression is developmentally regulated to coincide with the abrupt increase in the volume and cell size of the male's or the estrogen-treated female's song system.
authors.affiliation: Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA.
authors.forename: E
authors.initials: E
authors.lastname: Akutagawa
authors.forename: M
authors.initials: M
authors.lastname: Konishi
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D034961:Antigens, Nuclear; D015153:Blotting, Western; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D002171:Canaries; D003423:Critical Period, Psychological; D000939:Epitopes / Q000032:analysis / Q000276:immunology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000502:physiology; D009687:Nuclear Proteins / Q000032:analysis / Q000276:immunology*; D011233:Precipitin Tests; D012727:Sex Characteristics; D020308:Songbirds / Q000502:physiology*; D014828:Vocalization, Animal / Q000502:physiology*
chemical_list: D000911:Antibodies, Monoclonal; D034961:Antigens, Nuclear; D000939:Epitopes; D009687:Nuclear Proteins; D004958:Estradiol