Congenital varicella syndrome as an unusual cause of congenital malformation: report of one case.
Intrauterine infections with varicella-zoster virus following maternal varicella in early pregnancy and resulting in congenital malformations are rare. Herein we report a child with congenital varicella syndrome characterized by low birth weight, cicatricial scarring, hypoplasia of both lower extremities with joint contracture, congenital hip dislocation, corneal opacity, atresia of the sigmoid colon and a rarely associated cloaca anomaly. The varicella IgG remained positive after she was seven months old. Her mother developed chickenpox at the 14th week of gestation. The purpose of this article is to raise pediatricians' index of suspicion for congenital varicella syndrome when an infant is born with multiple congenital malformations with an apparent history of maternal varicella infection.
Huang
C S
CS
Department of Pediatrics, MacKay Memorial Hospital, 92, Sec. 2, Chung Shan North Road, Taipei 104, Taiwan.
Lin
S P
SP
Chiu
N C
NC
Hung
H Y
HY
D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000628:therapy / Q000821:virology*; D000328:Adult; D002644:Chickenpox / Q000151:congenital*; D002988:Cloaca / Q000002:abnormalities; D003106:Colon / Q000002:abnormalities; D005260:Female; D005315:Fetal Diseases / Q000821:virology*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007866:Leg / Q000002:abnormalities; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D011256:Pregnancy Outcome; D018570:Risk Assessment; D012868:Skin Abnormalities; D013577:Syndrome