Asymmetric synthesis of (-)-indolizidine 209D via B-alkyl Suzuki coupling and amination reactions.
(-)-Indolizidine 209D has been synthesized using consecutive amination reactions of compound 11. The precursor was prepared concisely using B-alkyl Suzuki cross coupling of chiral homoallyl amine and vinyl iodide compounds. Reaction: see text.
Kim
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Department of Chemistry, College of Natural Science, Chungnam National University, Taejon 305-764, Korea. guncheol@cuvic.cnu.ac.kr
Jung
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SD
Kim
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WJ
D000470:Alkaloids / Q000138:chemical synthesis*; D000588:Amines / Q000138:chemical synthesis; D000818:Animals; D007212:Indolizines / Q000138:chemical synthesis*; D018733:Nicotinic Antagonists / Q000138:chemical synthesis; D011898:Ranidae; D013237:Stereoisomerism
D000470:Alkaloids; D000588:Amines; D007212:Indolizines; D018733:Nicotinic Antagonists; C449379:indolizidine 209D