title: Genetic variation among the Golla pastoral caste subdivisions of Andhra Pradesh, India, according to the HLA system.
abstract: The HLA allele frequency distributions have been characterized for the HLA class I and class II loci of the Golla pastoral caste, from Southeast India, subdivided into the subcastes (Puja, Punugu, Kurava, Pokanati, Karnam, and Doddi). Genetic distances, neighbor-joining, correspondence, and haplotype analyses all indicate that the subcastes exhibit a high haplotype variability and that their genetic substratum may be the result of European-Middle East/Asian admixture with the autochthonous populations. The Karnam subcaste seems to be the one that has undergone a higher degree of admixture, when compared with the other subcastes. The Golla speak an old Indian Dravidian language and should theoretically represent the basic Indian substratum that existed before the postulated "Aryan" invasion.
authors.affiliation: Laboratory of Biological Anthropology, Department of Anthropology, University of Kansas, Lawrence, KS 66045, USA. crawford@kuhub.cc.ukans.edu
authors.forename: M H
authors.initials: MH
authors.lastname: Crawford
authors.forename: B M
authors.initials: BM
authors.lastname: Reddy
authors.forename: J
authors.initials: J
authors.lastname: Martinez-Laso
authors.forename: S J
authors.initials: SJ
authors.lastname: Mack
authors.forename: H A
authors.initials: HA
authors.lastname: Erlich
mesh_terms: D000328:Adult; D000483:Alleles; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D006801:Humans; D007194:India; D015810:Linkage Disequilibrium / Q000235:genetics; D012923:Social Class
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains