title: Inhibitory activity of lignan components from the flower buds of Magnoliae fargesii on the expression of cell adhesion molecules.
abstract: Inhibitory activity of lignans isolated from Magnoliae fargesii Cheng on cell adhesion molecules on the surface of THP-1 human monocytic cell lines were investigated. Among 16 lignan components tested, six displayed relatively potent inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).
authors.affiliation: Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon.
authors.forename: K S
authors.initials: KS
authors.lastname: Ahn
authors.forename: K Y
authors.initials: KY
authors.lastname: Jung
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: S R
authors.initials: SR
authors.lastname: Oh
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003864:Depression, Chemical; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D017705:Lignans / Q000494:pharmacology*; D029562:Magnoliaceae / Q000737:chemistry*; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D028321:Plant Preparations / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000494:pharmacology; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis*
chemical_list: D000911:Antibodies, Monoclonal; D017705:Lignans; D028321:Plant Preparations; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1