title: Hemodynamic effects of microgravity and their ground-based simulations.
abstract: Hemodynamic effects of simulated microgravity were investigated, in various experiments, using radioactive isotopes, in which 40 healthy men, aged 35 to 42 years, took part.  Blood shifts were evaluated qualitatively and quantitatively.  Simulation studies included bedrest, head-down tilt (-5 degrees  and -15 degrees), and vertical water immersion, it was found that none of the methods could entirely simulate hemodynamic effects of microgravity.  Subjective sensations varied in a wide range.  They cannot be used to identify reliably the effects of real and simulated microgravity.  Renal fluid excretion in real and simulated microgravity was different in terms of volume and time.  The experiments yielded data about the general pattern of circulation with blood displaced to the upper body.
authors.affiliation: Institute for Biomedical Problems, USSR Ministry of Health.
authors.forename: V I
authors.initials: VI
authors.lastname: Lobachik
authors.forename: S V
authors.initials: SV
authors.lastname: Abrosimov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhidkov
authors.forename: D K
authors.initials: DK
authors.lastname: Endeka
mesh_terms: D000328:Adult; D001510:Bed Rest / Q000009:adverse effects*; D005069:Evaluation Studies as Topic; D018495:Fluid Shifts / Q000502:physiology*; D018475:Head-Down Tilt / Q000009:adverse effects*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007101:Immersion / Q000009:adverse effects*; D008297:Male; D010953:Plasma Volume / Q000502:physiology; D016683:Supine Position; D013997:Time Factors; D018474:Weightlessness Simulation / Q000009:adverse effects / Q000379:methods*