title: Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.
abstract: (E)- and (Z)-5-Desamino huperzine A derivatives have been synthesized using a new synthetic strategy towards the huperzine A skeleton. These derivatives showed AChE inhibition constants in the low micromolar range and thus display better activity than all previously synthesized C5 derivatives.
authors.affiliation: Institut für Organische Chemie, Universität Wien, Währingerstrasse 38, A-1090 Wien, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Högenauer
authors.forename: K
authors.initials: K
authors.lastname: Baumann
authors.forename: A
authors.initials: A
authors.lastname: Enz
authors.forename: J
authors.initials: J
authors.lastname: Mulzer
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C439167:5-desamino huperzine A; D001952:Bridged-Ring Compounds; D002800:Cholinesterase Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D000110:Acetylcholinesterase