title: Base mutation analysis by a ferrocenyl naphthalene diimide derivative.
abstract: An electrochemical DNA sensing technique was developed by using ferrocenyl naphthalene diimide coupled with a probe DNA-immobilized electrode. This technique enabled detection of target DNA quickly and with high sensitivity. Applicability of this technique for single nucleotide polymorphisms (SNPs) analysis was demonstrated by successful analysis of a DNA mismatch on the cancer repression gene p53 with high precision.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takenaka
authors.forename: H
authors.initials: H
authors.lastname: Miyahara
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Takagi
authors.forename: H
authors.initials: H
authors.lastname: Kondo
mesh_terms: D004247:DNA / Q000032:analysis* / Q000235:genetics; D004252:DNA Mutational Analysis / Q000379:methods*; D004566:Electrodes; D005296:Ferrous Compounds / Q000737:chemistry*; D016158:Genes, p53 / Q000235:genetics; D007094:Imides / Q000737:chemistry*; D009154:Mutation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D020641:Polymorphism, Single Nucleotide
chemical_list: D005296:Ferrous Compounds; D007094:Imides; D009841:Oligonucleotides; C406363:ferrocenylnaphthalene diimide; D004247:DNA