Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues.
Proven conformationally restricted analogues of anticonvulsant functionalized amino acids (FAAs) were prepared using short-range cyclizations and evaluated in pharmacological assays providing new information concerning the structural requirements for FAA function.
LeTiran
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Department of Chemistry, University of Houston, TX 77204-5641, USA.
Stables
J P
JP
Kohn
H
H
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D015195:Drug Design; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009447:Neuroblastoma; D010433:Pentylenetetrazole / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology / Q000633:toxicity; D010672:Phenytoin / Q000494:pharmacology / Q000633:toxicity; D011392:Proline / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism; D015222:Sodium Channels / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000596:Amino Acids; D000927:Anticonvulsants; D006827:Hydantoins; D007769:Lactams; D015222:Sodium Channels; D013777:Tetrazoles; D010672:Phenytoin; D011392:Proline; D010433:Pentylenetetrazole; D010634:Phenobarbital