Specific binding and stabilization of DNA and phosphorothioate DNA by amphiphilic alpha-helical peptides.
Synthetic cationic peptides with amphiphilic alpha-helical structure were found to have DNA binding ability to stabilize double and triple stranded DNA. The stabilization effect was significant for cationic alpha-helical peptides indicating the importance of an electrostatic interaction of a positive charge of peptides and a negative charge of DNAs.
Kubo
T
T
Department of Chemistry, School of Engineering, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan.
Fujii
M
M
D000595:Amino Acid Sequence; D002412:Cations; D004247:DNA / Q000737:chemistry*; D004355:Drug Stability; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013379:Substrate Specificity
D002412:Cations; D009841:Oligonucleotides; D009842:Oligopeptides; D010710:Phosphates; C051802:triplex DNA; C083120:phosphorodithioic acid; D004247:DNA