title: Recurrent chromosomal rearrangements involving breakpoints 3p21 and 19q13 in Chinese IgD multiple myeloma detected by G-banding and multicolor spectral karyotyping: a review of IgD karyotype literature.
abstract: Immunoglobulin D multiple myeloma (IgD MM) is a rare subtype that accounts for 1% to 3% of MM and shows higher aggressiveness with distinctive clinical and laboratory features. However, there is little information in the literature on their karyotypes, which are mainly derived from G-banding results. Our current study on 2 Chinese IgD MM thus represents the first description of cytogenetic data on this subtype based on an integrated analysis with G-banding and multicolor spectral karyotyping (SKY). Both of our cases showed some usual features of MM, as well as a few novel translocations including t(3;22), t(6;19), t(X;19) and the 3 whole-arm translocations namely t(1;6)(q10;p10), t(4;9)(q10;p10), and t(16;18)(q10;q10). We also identified recurrent chromosomal rearrangements involving breakpoints 3p21 and 19q13, which may suggest to be unique aberrations that may underline the pathogenesis of this distinctive biological MM subtype.
authors.affiliation: Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T. Hong Kong SAR.
authors.forename: M H
authors.initials: MH
authors.lastname: Ng
authors.forename: N
authors.initials: N
authors.lastname: Wong
authors.forename: K S
authors.initials: KS
authors.lastname: Tsang
authors.forename: S H
authors.initials: SH
authors.lastname: Cheng
authors.forename: Y F
authors.initials: YF
authors.lastname: Chung
authors.forename: K W
authors.initials: KW
authors.lastname: Lo
mesh_terms: D000368:Aged; D002871:Chromosome Banding / Q000379:methods; D019457:Chromosome Breakage / Q000235:genetics*; D002873:Chromosome Fragility; D020223:Chromosome Painting / Q000379:methods; D002888:Chromosomes, Human, Pair 19; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D007072:Immunoglobulin D; D007621:Karyotyping / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000276:immunology* / Q000473:pathology
chemical_list: D007072:Immunoglobulin D