Enantioselective autocatalysis.  II.  Racemization studies on a 1,4-benzodiazepinooxazole derivative.
Since the bromofluoro-1,4-benzodiazepinooxazole derivative I may undergo spontaneous resolution on crystallization from methanol solution, it provides an ideal substrate on which to study the phenomenon of enantioselective autocatalysis involving spontaneous resolution under racemizing conditions (SRURC).  In order to augment the understanding of factors which might be important in such a process we have now undertaken to study the racemization of I in more detail by observing its rate under a wide variety of experimental conditions.
Bonner
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Department of Chemistry, Stanford University, CA 94035, USA.
D019342:Acetic Acid / Q000737:chemistry; D000096:Acetone / Q000737:chemistry*; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000737:chemistry*; D002384:Catalysis; D003460:Crystallization; D019418:Evolution, Chemical; D006851:Hydrochloric Acid / Q000737:chemistry; D000432:Methanol / Q000737:chemistry*; D009904:Optical Rotation; D012972:Sodium Hydroxide / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; D000096:Acetone; D012972:Sodium Hydroxide; C018779:haloxazolam; D019342:Acetic Acid; D006851:Hydrochloric Acid; D000432:Methanol