title: DNA-photocleavage agents.
abstract: This review describes recent advances in the development of DNA-photocleavage agents. Major mechanisms of photosensitized DNA photocleavage are presented and the most popular categories of compounds are considered, which include metal complexes and many organic functional derivatives. DNA-targeted conjugates of photosensitizers are also described and discussed.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy. prato@univ.trieste.it
authors.forename: T
authors.initials: T
authors.lastname: Da Ros
authors.forename: G
authors.initials: G
authors.lastname: Spalluto
authors.forename: A S
authors.initials: AS
authors.lastname: Boutorine
authors.forename: R V
authors.initials: RV
authors.lastname: Bensasson
authors.forename: M
authors.initials: M
authors.lastname: Prato
mesh_terms: D001483:Base Sequence / Q000187:drug effects; D001665:Binding Sites / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D053938:DNA Fragmentation / Q000187:drug effects; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D017319:Photosensitizing Agents; D004247:DNA