title: Structure-activity relationships of apio nucleosides as potential antiviral agents.
abstract: Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, Korea.
authors.forename: L S
authors.initials: LS
authors.lastname: Jeong
authors.forename: H R
authors.initials: HR
authors.lastname: Moon
authors.forename: J H
authors.initials: JH
authors.lastname: Hong
authors.forename: S J
authors.initials: SJ
authors.lastname: Yoo
authors.forename: W J
authors.initials: WJ
authors.lastname: Choi
authors.forename: H O
authors.initials: HO
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Ahn
authors.forename: H W
authors.initials: HW
authors.lastname: Baek
authors.forename: M W
authors.initials: MW
authors.lastname: Chun
authors.forename: H D
authors.initials: HD
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: J R
authors.initials: JR
authors.lastname: Choi
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides