Dealkylation of phosphonate esters with chlorotrimethylsilane.
Chlorotrimethylsilane completely dealkylates phosphonate esters at elevated temperature in a sealed reaction vessel. These conditions are tolerated by a variety of functional groups and lead to high conversions of dimethyl, diethyl and diisopropyl phosphonates to their corresponding phosphonic acids.
Gutierrez
A J
AJ
Department of Chemical Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, USA.
Prisbe
E J
EJ
Rohloff
J C
JC
D003640:Dealkylation; D063065:Organophosphonates / Q000737:chemistry*; D017905:Phosphites / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
D063065:Organophosphonates; D017905:Phosphites; D014297:Trimethylsilyl Compounds; C039293:trimethylchlorosilane; C047356:dimethyl hydrogen phosphite