title: IS-741 (Ishihara Sangyo).
abstract: IS-741 is a phospholipase A2 (PLA2) inhibitor under development by Ishihara Sangyo Kaisha and Sumitomo as a potential treatment for pancreatitis 1187575]. Sumitomo is developing the drug in phase II trials for acute pancreatitis 13990261. In an animal model, IS-741 has been shown to prevent pancreatitis-associated lung injury following endotoxemia [337503].
authors.affiliation: Surgical and Gastroenterological Department, University of Verona, Hospital GB Rossi, Verona, Italy. Claudio.Bassi@univr.it
authors.forename: C
authors.initials: C
authors.lastname: Bassi
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D010195:Pancreatitis / Q000188:drug therapy*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D011725:Pyridines; C097462:IS 741; D010741:Phospholipases A; D054467:Phospholipases A2