Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics.
A series of novel resorcin-[4]arenes with extended pi systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.
Wright
A J
AJ
Department of Chemistry, University of Oxford, UK.
Matthews
S E
SE
Fischer
W B
WB
Beer
P D
PD
D002352:Carrier Proteins / Q000737:chemistry*; D007202:Indicators and Reagents; D008051:Lipid Bilayers / Q000737:chemistry; D008564:Membrane Potentials; D008968:Molecular Conformation; D015394:Molecular Structure; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry*
D002352:Carrier Proteins; D007202:Indicators and Reagents; D008051:Lipid Bilayers; D015221:Potassium Channels; D012118:Resorcinols; D011188:Potassium