Inhibition of overexpression of endothelin-1 by an RNA synthesis inhibitor, doxorubicin, in the rat vasospasm model.
Mima
T
T
Department of Neurosurgery, Kochi Medical School, Kochi, Japan.
Mostafa
M G
MG
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D019332:Endothelin-1 / Q000037:antagonists & inhibitors* / Q000235:genetics*; D008297:Male; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D012333:RNA, Messenger / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D020301:Vasospasm, Intracranial / Q000378:metabolism*
D019332:Endothelin-1; D019384:Nucleic Acid Synthesis Inhibitors; D012333:RNA, Messenger; D004317:Doxorubicin