title: Antiprogestagen activity of 5H-progesterone metabolites and their analogues, 16alpha,17alpha-cyclohexane-5H-pregnan-3,20-diones.
abstract: Antiprogestin activity of 5H-progesterone metabolites and their analogues 16alpha,17alpha-cyclohexan-5H-pregnan-3,20-diones was tested on rats. Modified pregnancy interruption test showed that 5alpha (H)-isomers of natural and synthetic hormones exhibit maximum activity.
authors.affiliation: Department of Molecular Pharmacology and Radiobiology, Medical Biological Faculty of the Russian State Medical University, Moscow.
authors.forename: E N
authors.initials: EN
authors.lastname: Kareva
authors.forename: A V
authors.initials: AV
authors.lastname: Kamernitskii
authors.forename: I S
authors.initials: IS
authors.lastname: Levina
authors.forename: N V
authors.initials: NV
authors.lastname: Kirpichnikova
authors.forename: L E
authors.initials: LE
authors.lastname: Kulikova
authors.forename: V V
authors.initials: VV
authors.lastname: Podval'nyuk
mesh_terms: D000021:Abortifacient Agents, Steroidal / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D005260:Female; D015735:Mifepristone / Q000494:pharmacology; D015394:Molecular Structure; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000187:drug effects*; D011270:Pregnancy, Animal; D011280:Pregnanolone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism*; D011372:Progestins / Q000037:antagonists & inhibitors*; D051381:Rats
chemical_list: C445420:16,17-cyclohexane-5H-pregnan-3,20-dione; D000021:Abortifacient Agents, Steroidal; D011372:Progestins; D015735:Mifepristone; D011374:Progesterone; D011280:Pregnanolone