The ACVD task force on canine atopic dermatitis (III): the role of antibodies in canine atopic dermatitis.
Although an important pathogenic role for IgE is established in the case of allergic asthma and rhinitis in man, its role in atopic dermatitis is less clear. There are many studies where allergists and immunologists have provided evidence in favour of such a role, whereas dermatologists are less than convinced. In dogs, however, there is an abundance of clinical evidence implying that atopic dermatitis is antigen driven, and recent studies suggest that there may be a role for IgE, not only in the effector pathway, but also in antigen capture. Although an IgG response often accompanies an IgE response in dogs with atopic dermatitis, there is little evidence in support of a pathogenic role in respect of the former isotype.
Halliwell
R E
RE
Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall Square, Edinburgh EH9 1QH, UK. rhalliwell@vet.ed.ac.uk
DeBoer
D J
DJ
D000485:Allergens / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000502:physiology*; D003876:Dermatitis, Atopic / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology / Q000276:immunology*; D004285:Dogs; D006801:Humans; D012955:Societies, Medical; D014481:United States
D000485:Allergens; D000906:Antibodies