title: Carotenoids are degraded by free radicals but do not affect lipid peroxidation in unilamellar liposomes under different oxygen tensions.
abstract: It has been questioned whether carotenoids can act as antioxidants in biological membranes. Biological membranes can be modeled for studies of lipid peroxidation using unilamellar liposomes. Both carotenoid depletion and lipid peroxidation were increased with increasing oxygen tension in unilamellar liposomes. Carotenoids in such liposomes were found to be very sensitive to degradation by free radicals generated from iron and 2,2'-azobis(2-amidinopropane) dihydrochloride, but they were not protective against lipid peroxidation. Lycopene and beta-carotene were more sensitive to free radical attack than lutein, zeaxanthin, and beta-cryptoxanthin.
authors.affiliation: Barbara Ann Karmanos Cancer Institute, 110 East Warren Ave., Detroit, MI 48201, USA.
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Djuric
mesh_terms: D000578:Amidines / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D002338:Carotenoids / Q000737:chemistry / Q000378:metabolism*; D065366:Cryptoxanthins; D015237:Dinoprost / Q000031:analogs & derivatives / Q000378:metabolism; D028441:F2-Isoprostanes; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000737:chemistry; D015227:Lipid Peroxidation; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D014975:Lutein / Q000737:chemistry / Q000378:metabolism; D000077276:Lycopene; D010100:Oxygen / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D024341:Xanthophylls; D019207:beta Carotene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
chemical_list: D000578:Amidines; D000975:Antioxidants; D065366:Cryptoxanthins; D028441:F2-Isoprostanes; D005609:Free Radicals; D008081:Liposomes; D017392:Thiobarbituric Acid Reactive Substances; D024341:Xanthophylls; D019207:beta Carotene; C075750:8-epi-prostaglandin F2alpha; D002338:Carotenoids; C046728:2,2'-azobis(2-amidinopropane); D015237:Dinoprost; D007501:Iron; D010100:Oxygen; D000077276:Lycopene; D014975:Lutein