Ventral neurogenesis and the neuron-glial switch.
In the developing spinal cord, neuroepithelial precursors at different positions along the dorsal-ventral axis generate distinct neuronal and glial subtypes. For example, one group of ventral precursors generates neurons followed by oligodendrocytes. A spate of recent articles, including several in this issue of Neuron, are devoted to the mechanisms governing neuronal and glial subtype specification in the ventral cord. We review these studies and discuss the nature of the ventral neuron-oligodendrocyte switch.
Kessaris
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Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, WC1E 6AE, London, United Kingdom.
Pringle
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Richardson
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D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009836:Oligodendroglia / Q000166:cytology / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology
D018398:Homeodomain Proteins