Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr.
In a longitudinal study of the effects of moderate (70%) dietary restriction (DR) on aging, plasma glucose and insulin concentrations were measured from semiannual, frequently sampled intravenous glucose tolerance tests (FSIGTT) in 30 adult male rhesus monkeys. FSIGTT data were analyzed with Bergman's minimal model, and analysis of covariance revealed that restricted (R) monkeys exhibited increased insulin sensitivity (S(I), P < 0.001) and plasma glucose disappearance rate (K(G), P = 0.015), and reduced fasting plasma insulin (I(b), P < 0.001) and insulin response to glucose (AIR(G), P = 0.023) compared with control (C; ad libitum-fed) monkeys. DR reduced the baseline fasting hyperinsulinemia of two R monkeys, whereas four C monkeys have maintained from baseline, or subsequently developed, fasting hyperinsulinemia; one has progressed to diabetes. Compared with only the normoinsulinemic C monkeys, R monkeys exhibited similarly improved FSIGTT and minimal-model parameters. Thus chronic DR not only has protected against the development of insulin resistance in aging rhesus monkeys, but has also improved glucoregulatory parameters compared with those of otherwise normoinsulinemic monkeys.
Gresl
T A
TA
Wisconsin Regional Primate Research Center, Madison 53715, USA.
Colman
R J
RJ
Roecker
E B
EB
Havighurst
T C
TC
Huang
Z
Z
Allison
D B
DB
Bergman
R N
RN
Kemnitz
J W
JW
D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004038:Diet, Reducing; D018450:Disease Progression; D002149:Energy Intake; D005215:Fasting; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006946:Hyperinsulinism / Q000503:physiopathology*; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D000078790:Insulin Secretion; D008253:Macaca mulatta / Q000254:growth & development*; D008297:Male; D008954:Models, Biological; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin