Susceptibilities of human cytomegalovirus clinical isolates to BAY38-4766, BAY43-9695, and ganciclovir.
BAY38-4766 and BAY43-9695 are nonnucleosidic compounds with activities against human cytomegalovirus (HCMV). Two phenotypic assays were used to determine the drug susceptibilities of 36 HCMV clinical isolates to the BAY compounds and ganciclovir. Using either assay, both BAY compounds at a concentration of approximately 1 microM inhibited the replication of all 36 HCMV clinical isolates, including 11 ganciclovir-resistant clinical isolates, by 50%.
McSharry
J J
JJ
Center for Immunology and Microbial Diseases, Albany Medical College, 47 New Scotland Ave., Albany, NY 12208, USA. mcsharj@mail.amc.edu
McDonough
A
A
Olson
B
B
Hallenberger
S
S
Reefschlaeger
J
J
Bender
W
W
Drusano
G L
GL
D000998:Antiviral Agents / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects* / Q000502:physiology; D015774:Ganciclovir / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009282:Naphthalenesulfonates / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
C434758:3-hydroxy-2,2-dimethyl-N-(4(((5-(dimethylamino)-1-naphthyl)sulfonyl)amino)phenyl)propanamide; D000998:Antiviral Agents; C439347:BAY43-9695; D009282:Naphthalenesulfonates; D015774:Ganciclovir