[Changes of serum biochemical parameters during hypothermia and hypoxia in rats].
OBJECTIVE
To study the effects of hypothermia and hypoxia on serum biochemical parameters. Method Acute hypobaric hypoxia experiment in cold environment was carried out in 48 healthy Wistar rats to observe changes of hepatic, cardiac and renal functions.


RESULTS
Hepatic, cardiac and renal functions changed non-prominently after acute hypoxia exposure under cold condition. Under hypoxic exposure of the same degree, serum lactic dehydrogenase(LDH), alanine transaminase(ALT), blood urea nitrogen (BUN) and creatinine (Cr) increased more significantly at 10 degrees C than those at 20 degrees C (P < 0.01) while creatine kinase (CK) decreased significantly at 10 degrees C than that at 20 degrees C.


CONCLUSIONS
After acute hypoxia in cold environment, the changes in cardiac function did not simply equal to the changes by cold environment plus changes by acute hypoxia.
Mei
D
D
Air Force Medical College, Jilin, China.
Xu
B
B
Sun
K
K
Wang
L H
LH
Zhang
W
W
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001806:Blood Urea Nitrogen; D002320:Cardiovascular Physiological Phenomena; D003080:Cold Temperature / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood; D006334:Heart Function Tests; D007035:Hypothermia / Q000097:blood* / Q000201:enzymology / Q000209:etiology / Q000378:metabolism*; D000860:Hypoxia / Q000097:blood* / Q000201:enzymology / Q000209:etiology / Q000378:metabolism*; D007668:Kidney / Q000502:physiology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase; D003402:Creatine Kinase