title: Conservative treatment of hemolytic complication following coil embolization in two adult cases of patent ductus arteriosus.
abstract: Two adult cases of relatively large patent ductus arteriosus (PDA) were treated by coil embolization, but were complicated by hemolysis that was successfully managed by medical treatment. Case 1 was a 67-year-old woman and Case 2 was a 71-year-old woman with a PDA of minimal diameter of 5.3 mm and 5.5 mm, respectively. The approach was via the pulmonary artery and 2 coils were delivered simultaneously into the ductus, known as the 'kissing coil technique'. Although immediately after the procedure only a small residual shunt was revealed by aortogram, hemolysis occurred for several hours after the procedure in both cases. A hemolytic complication usually needs additional coil embolization or surgical treatment, but in these 2 cases it was successfully treated by haptoglobin infusion to prevent nephropathy and by antiplasmin infusion to promote thrombus formation. Hemolytic complications of coil embolization of PDA can managed by medication when the residual shunt is minimal and the degree of hemolysis is mild.
authors.affiliation: Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
authors.forename: K
authors.initials: K
authors.lastname: Eda
authors.forename: S
authors.initials: S
authors.lastname: Ohtsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Seo
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Ishiyama
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.forename: H
authors.initials: H
authors.lastname: Horigome
authors.forename: I
authors.initials: I
authors.lastname: Yamaguchi
mesh_terms: D000368:Aged; D004374:Ductus Arteriosus, Patent / Q000150:complications* / Q000628:therapy; D004621:Embolization, Therapeutic / Q000009:adverse effects*; D005260:Female; D006242:Haptoglobins / Q000008:administration & dosage; D006456:Hemoglobinuria / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D006461:Hemolysis; D006801:Humans; D000979:alpha-2-Antiplasmin / Q000008:administration & dosage
chemical_list: D006242:Haptoglobins; D000979:alpha-2-Antiplasmin