Prognostic value of cytokines in SIRS general medical patients.
We studied 174 patients with SIRS criteria, 45 with sepsis, eight with severe sepsis and 13 with septic shock. Serum TNF-alpha, IL-6, IL-8 and IL-10 levels were raised in SIRS patients, even in those cases in which an infection could not be documented, and more intensely in severe sepsis and in patients who died (11%). The slope of the regression line between IL-10 and TNF-alpha was sharper in patients with severe sepsis and in those who died; an imbalance between pro- and anti-inflammatory cytokines may be related to poor prognosis. Increased IL-6 and IL-10, decreased muscle mass, raised BUN and low body temperature were all independently related to prognosis.
Rodríguez-Gaspar
M
M
Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Spain.
Santolaria
F
F
Jarque-López
A
A
González-Reimers
E
E
Milena
A
A
de la Vega
M J
MJ
Rodríguez-Rodríguez
E
E
Gómez-Sirvent
J L
JL
D000367:Age Factors; D000368:Aged; D001831:Body Temperature; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D016753:Interleukin-10 / Q000096:biosynthesis / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D011379:Prognosis; D018805:Sepsis / Q000175:diagnosis* / Q000276:immunology* / Q000401:mortality; D012772:Shock, Septic / Q000175:diagnosis* / Q000276:immunology* / Q000401:mortality; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10