title: Prevention of postoperative nausea and vomiting after laparoscopic gynaecological surgery. Combined antiemetic treatment with tropisetron and metoclopramide vs. metoclopramide alone.
abstract: OBJECTIVE
  Female patients undergoing gynaecological procedures, especially laparoscopically, are at high risk of postoperative nausea and vomiting. No available antiemetic is entirely effective. This double-blinded randomized trial examines the efficacy and safety of tropisetron and metoclopramide in combination and compares the results with metoclopramide alone in laparoscopic gynaecological surgery.
  
  
  METHODS
  One hundred and twenty female patients scheduled for minor gynaecological laparoscopy, aged 27-43 years, were randomly allocated to receive pretreatment with metoclopramide 10 mg intravenously (n=57) or tropisetron 5 mg with metoclopramide 5 mg (n=63).
  
  
  RESULTS
  Fewer patients in the combined treatment group experienced postoperative nausea and vomiting (14% vs. 37%, P=0.008) or needed rescue antiemetic treatment (3% vs. 16%, P=0.038). No significant adverse events were observed.
  
  
  CONCLUSIONS
  The combination of the antiemetics was superior, which is probably explained by the fact that the two drugs have different sites of action, thus preventing emesis by blocking different pathways.
authors.affiliation: The Anaesthesiology Unit, Aretaieion Hospital, 115 28 Athens, Greece.
authors.forename: L
authors.initials: L
authors.lastname: Papadimitriou
authors.forename: S
authors.initials: S
authors.lastname: Livanios
authors.forename: G
authors.initials: G
authors.lastname: Katsaros
authors.forename: D
authors.initials: D
authors.lastname: Hassiakos
authors.forename: T
authors.initials: T
authors.lastname: Koussi
authors.forename: T
authors.initials: T
authors.lastname: Demesticha
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000009:adverse effects*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D010535:Laparoscopy; D008787:Metoclopramide / Q000009:adverse effects*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D000077526:Tropisetron
chemical_list: D000932:Antiemetics; D007211:Indoles; D000077526:Tropisetron; D008787:Metoclopramide