title: A prospective comparison of octyl cyanoacrylate tissue adhesive (dermabond) and suture for the closure of excisional wounds in children and adolescents.
abstract: BACKGROUND
  Recent studies suggest that the use of octyl cyanoacrylate tissue adhesive for closure of both traumatic lacerations and incisional surgical wounds results in a cosmetic outcome comparable to that achieved with conventional sutures. To date, no studies have looked at the use of tissue adhesive for higher-tension wounds, such as those created during cutaneous excisional procedures.
  
  
  OBJECTIVE
  To compare the tissue adhesive octyl cyanoacrylate with standard suture for the closure of excisional wounds in children and adolescents.
  
  
  METHODS
  A prospective comparison with blinded assessment of cosmetic outcome. Twenty-eight wounds were closed with monofilament suture and 24 were closed with tissue adhesive. At approximately 2 months, photographs of the incisions were evaluated by 2 dermatologists blinded to the method of skin closure.
  
  
  METHODS
  Forty-two consecutive patients undergoing excisional dermatologic procedures at Children's Hospital, San Diego, Calif. These 42 patients had a total of 52 wounds that were evaluated.
  
  
  METHODS
  The cosmetic appearance of the wounds at 2 months, based on 2 validated wound scales: the Hollander Wound Evaluation Scale and a visual analog scale.
  
  
  RESULTS
  There were no differences in early complications between the groups. The suture group scored higher on the visual analog scale (63.3 mm for suture vs 47.8 mm for tissue adhesive), and this difference was statistically significant (P =.02). The suture group also had a higher median score on the Hollander Wound Evaluation Scale, but this difference was not statistically significant (P =.09).
  
  
  CONCLUSIONS
  The cosmetic outcome of cutaneous excisional surgery wounds closed with standard suturing was found to be superior to that of wounds closed with octyl cyanoacrylate.
authors.affiliation: Children's Hospital and HealthCenter, 3030 Children's Way, Suite 408, San Diego, CA 92123, USA.
authors.forename: L
authors.initials: L
authors.lastname: Bernard
authors.forename: J
authors.initials: J
authors.lastname: Doyle
authors.forename: S F
authors.initials: SF
authors.lastname: Friedlander
authors.forename: L F
authors.initials: LF
authors.lastname: Eichenfield
authors.forename: N F
authors.initials: NF
authors.lastname: Gibbs
authors.forename: B B
authors.initials: BB
authors.lastname: Cunningham
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017439:Cicatrix, Hypertrophic / Q000209:etiology; D003487:Cyanoacrylates / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004954:Esthetics; D005500:Follow-Up Studies; D006801:Humans; D017060:Patient Satisfaction; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000601:surgery*; D013537:Sutures; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C119247:octylcyanoacrylate