title: T-cell-rich B-cell lymphoma in a ring-tailed lemur (Lemur catta).
abstract: A 13-yr-old ring-tailed lemur (Lemur catta) was evaluated for depression, anorexia, polyuria, and polydipsia. The lemur was in poor body condition and was anemic, hypoalbuminemic, and hyponatremic. Cytologic examination of aspirates of the spleen, liver, and bone marrow and histopathologic examination of liver and bone marrow biopsies revealed a disseminated round cell tumor. After euthanasia, necropsy revealed hepatomegaly, splenomegaly, and mesenteric lymphadenomegaly. Neoplastic cells were present within the spleen, liver, kidneys, multiple lymph nodes, bone marrow, lung, small intestine, pancreas, and testicle and were composed of large anaplastic round cells in a background of small well-differentiated lymphocytes. Immunohistochemical analysis revealed that the small well-differentiated lymphocytes labeled for the anti-human T-cell marker, CD3, and the large anaplastic round cells labeled with the anti-human B-cell marker, CD79a. On the basis of the immunohistochemical staining results and morphologic appearance, a diagnosis of a T-cell-rich B-cell lymphoma was made.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
authors.forename: G W
authors.initials: GW
authors.lastname: Pye
authors.forename: R A
authors.initials: RA
authors.lastname: Bennett
authors.forename: S P
authors.initials: SP
authors.lastname: Terrell
authors.forename: P E
authors.initials: PE
authors.lastname: Ginn
authors.forename: L J
authors.initials: LJ
authors.lastname: McSherry
authors.forename: A R
authors.initials: AR
authors.lastname: Alleman
mesh_terms: D000820:Animal Diseases / Q000473:pathology; D000818:Animals; D000855:Anorexia / Q000150:complications / Q000662:veterinary; D015703:Antigens, CD / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D051925:CD79 Antigens; D005065:Euthanasia / Q000662:veterinary; D006801:Humans; D007900:Lemur; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011141:Polyuria / Q000150:complications / Q000662:veterinary; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013601:T-Lymphocytes
chemical_list: D015703:Antigens, CD; D017252:CD3 Complex; D051925:CD79 Antigens; C497881:CD79A protein, human; D011947:Receptors, Antigen, B-Cell