Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells.
We report that 5-day exposure to physiological concentrations of eicosapentaenoic and docosahexaenoic acids resulted in a strong decrease in expression of the RIalpha regulatory subunit of protein kinase A and the PKC-alpha isozyme of protein kinase C in the human breast cancer cell line MDA-MB-231.
Moore
N G
NG
Department of Nutrition Sciences, The University of Alabama at Birmingham, 35294-3360, USA.
Wang-Johanning
F
F
Chang
P L
PL
Johanning
G L
GL
D001095:Arachidonic Acids / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000096:biosynthesis*; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007527:Isoenzymes; D011493:Protein Kinase C / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured
D001095:Arachidonic Acids; D007527:Isoenzymes; D004281:Docosahexaenoic Acids; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C