[Antioxidant effects of amtizol and trimetazidine in brain ischemia].
Effects of amtizol and trimetazidine (25 mg/kg, i.p., 30 min before and 6, 24, 48 h after the ischemia) on lipid peroxidation in the brain were studied in white rats undergoing occlusion of the common carotid arteries for 90 min, 24 h and 72 h. It was found that administration of the above drugs decreased accumulation of lipid hydroperoxides and malonic dialdehyde, corrected the activity of antioxidant enzymes in the brain after 90 min of ischemia, inhibited activation of lipid peroxidation, elevated the levels of thiol compounds, increased the activity of the glutathione antioxidant system after 24 and 72 h of ischemia.
Mironova
O P
OP
Zarubina
I V
IV
Krivoruchko
B I
BI
Smirnov
A V
AV
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D013830:Thiadiazoles / Q000627:therapeutic use*; D014292:Trimetazidine / Q000627:therapeutic use*
D000975:Antioxidants; D013830:Thiadiazoles; C044365:amtizol; D014292:Trimetazidine