title: Glycerol 3-phosphate inhibits swarming and aggregation of Myxococcus xanthus.
abstract: We have cloned a gene of Myxococcus xanthus with similarities to the permease for glycerol 3-phosphate (G3P) of other bacteria. Expression of the gene increased significantly during the first hours of starvation. Swarming of the wild-type strain was inhibited and aggregation was delayed by G3P. Conversely, a DeltaglpT strain aggregated even on rich medium. These results indicate that G3P may function to regulate the timing of aggregation in M. xanthus.
authors.affiliation: Departamento de Microbiología, Facultad de Ciencias, Universidad de Granada, Granada, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Moraleda-Muñoz
authors.forename: J
authors.initials: J
authors.lastname: Carrero-Lérida
authors.forename: A L
authors.initials: AL
authors.lastname: Extremera
authors.forename: J M
authors.initials: JM
authors.lastname: Arias
authors.forename: J
authors.initials: J
authors.lastname: Muñoz-Dorado
mesh_terms: D003001:Cloning, Molecular; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D005994:Glycerophosphates / Q000494:pharmacology*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000187:drug effects; D009068:Movement / Q000187:drug effects / Q000502:physiology*; D016941:Myxococcus xanthus / Q000187:drug effects / Q000502:physiology*; D010641:Phenotype
chemical_list: D005994:Glycerophosphates; D026901:Membrane Transport Proteins; C029620:alpha-glycerophosphoric acid