title: Fenofibrate-Induced elevation in serum creatinine.
abstract: Fenofibrate, a fibric acid derivative, is used as adjunctive therapy with diet for treatment of hyperlipidemia. Side effects include gastrointestinal complaints and, rarely, elevations in liver function tests. According to the drug's package insert, elevations in serum creatinine may occur; although, no postmarketing case reports of fenofibrate-induced elevations in serum creatinine are on file with the manufacturer. Fenofibrate was the probable cause of elevations in serum creatinine concentrations in six patients at our clinic. As the implications of these elevations may be serious, routine serum creatinine monitoring is recommended at baseline and 1-2 months after starting fenofibrate.
authors.affiliation: Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois 60515, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Ritter
authors.forename: S
authors.initials: S
authors.lastname: Nabulsi
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy / Q000009:adverse effects; D003404:Creatinine / Q000097:blood*; D005260:Female; D011345:Fenofibrate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D000960:Hypolipidemic Agents; D003404:Creatinine; D011345:Fenofibrate