Tandem chain extension-homoenolate formation: the formation of alpha-methylated-gamma-keto esters.
A tandem chain extension-homoenolate formation reaction is described. The treatment of beta-keto esters with the Furukawa reagent followed by exposure to a catalytic amount of trimethylsilyl chloride provides access to an ester homoenolate. Reaction: see text.
Hilgenkamp
R
R
Department of Chemistry, University of New Hampshire, Durham, NH 03824, USA.
Zercher
C K
CK
D004952:Esters / Q000138:chemical synthesis*; D007536:Isomerism; D007651:Keto Acids / Q000138:chemical synthesis*
D004952:Esters; D007651:Keto Acids