title: [Increase in NK-activity using superlow doses of the immunomodulator cycloferon].
abstract: A possibility of rising the antitumor activity of natural killers using various doses of the immunomodulator cycloferon was evaluated. A direct correlation has been revealed between the killer activity and the cycloferon dose. However, on a decrease in cycloferon concentrations by several orders, as compared with commonly accepted doses, this correlation changed for inverse. A possible mechanism of this effect is discussed in addition to practical significance of the obtained results.
authors.affiliation: Institute of Cytology RAS, St. Petersburg. shev@svs.ru
authors.forename: E V
authors.initials: EV
authors.lastname: Shevchenko
authors.forename: B B
authors.initials: BB
authors.lastname: Finkel'shteĭn
authors.forename: V A
authors.initials: VA
authors.lastname: Ivanov
mesh_terms: D000166:Acridines / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020014:K562 Cells; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D051379:Mice
chemical_list: D000166:Acridines; D000276:Adjuvants, Immunologic; C026430:10-carboxymethyl-9-acridanone