title: Possible association of temporomandibular joint pain and dysfunction with a polymorphism in the serotonin transporter gene.
abstract: The purpose of this study was to evaluate the relationship between temporomandibular joint pain and dysfunction and serotonin transporter (5-HTT) gene polymorphism. Forty-eight patients with temporomandibular joint pain and 111 healthy control subjects were examined. The results for the patients and control subjects were not significantly different (P >.05). The analysis of genotype distribution (homozygous for STin 2.10 genotypes of the variable-number tandem-repeat polymorphism) showed significant differences between the patients and control subjects (P =.003). ST 2.10 allele was more frequent in the patients with temporomandibular joint pain and dysfunction. In the control group, however, STin 2.12/12 genotype was significantly higher (P =.017). In the patients who were homozygous or heterozygous for variable-number tandem-repeat variants of 5-HTT STin 2.12 copies, the average scores of somatization and anger were significantly higher than those who were homozygous for STin 2.10 variant (P <.05). The patients who were homozygous for STin 2.10 genotype were also homozygous for "L" genotype (P =.019). However, this was not the condition in the control subjects. This study does not provide evidence to support the involvement of 5-HTT gene-linked polymorphic region in temporomandibular joint pain and dysfunction. Our findings indicated that only the presence of the homozygous STin 2.10 genotype of variable-number tandem-repeat is likely to play a substantial role in the genetic predisposition to temporomandibular joint pain and dysfunction and that the STin 2.12/12 genotype may have a protective role against temporomandibular joint pain and dysfunction.
authors.affiliation: Department of Psychiatry, Medical Faculty of Gaziantep University, Gaziantep, Turkey. hasanherken@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Herken
authors.forename: E
authors.initials: E
authors.lastname: Erdal
authors.forename: N
authors.initials: N
authors.lastname: Mutlu
authors.lastname: Barlas O
authors.forename: O
authors.initials: O
authors.lastname: Cataloluk
authors.forename: F
authors.initials: F
authors.lastname: Oz
authors.forename: E
authors.initials: E
authors.lastname: Güray
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D018598:Minisatellite Repeats; D009419:Nerve Tissue Proteins; D010555:Personality Inventory; D011110:Polymorphism, Genetic; D011336:Probability; D012701:Serotonin / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins; D013001:Somatoform Disorders / Q000235:genetics; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000235:genetics* / Q000523:psychology
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin