[The effect of cobavit on glutathione system in patients with bleeding gastroduodenal ulcer].
Index of glutathione system studied in 20 healthy persons (KG-1), in 20 with non-complicated duodenal ulcer (KG-2), in 210 patients with bleeding gastroduodenal ulcer, in 77 in early period after different operations. Results obtained showed that ulcer disease, complicated with bleeding was characterized by significant changes in glutathione system degree of which was depended on amount of the blood lost. Operations in early period enhanced disorders in glutathione system. Inclusion of cobavit into the complex of postoperative therapy provided recovery of glutathione pool activation of glutathiontransferase and glutathionreductase reaction that resulted in increase of withdrawal of toxic metabolites and activation of biosynthetic processes in patient's organism.
Ataliev
A E
AE
Mvlianov
A R
AR
Navruzov
G D
GD
Inoiatova
F Kh
FKh
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use*; D003035:Cobalt / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D018698:Glutamic Acid / Q000494:pharmacology* / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome; D014814:Vitamin U / Q000494:pharmacology* / Q000627:therapeutic use*
D000975:Antioxidants; D014814:Vitamin U; D003035:Cobalt; D018698:Glutamic Acid; D005978:Glutathione