title: Neuromuscular adaptations during 30 days of cast-immobilization and head-down bedrest.
abstract: Prolonged skeletal muscle disuse, during space flights and on Earth, produces distinct adaptive changes in the neuromuscular system of human subjects.  There is a significant decline in muscle mass and strength, exercise capacity, fatigue resistance, integrated EMG (IEMG) output and time-dependent alterations in the behavior of Hoffman (H) and deep tendon reflexes.  The objective of this study was to examine the changes in excitability of segmental motoneuronal network and its influence upon gastrocnemius-soleus (G-S) function in healthy male and female subjects, who underwent either 6 degrees head-down bedrest (HDB) or unilateral cast-immobilization (CIM) for a period of 30 days.
authors.affiliation: Dept. of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Jaweed
authors.forename: E A
authors.initials: EA
authors.lastname: Grana
authors.forename: T P
authors.initials: TP
authors.lastname: Glennon
authors.forename: T N
authors.initials: TN
authors.lastname: Monga
authors.forename: B
authors.initials: B
authors.lastname: Mirabi
mesh_terms: D000328:Adult; D001510:Bed Rest; D004576:Electromyography; D005260:Female; D006181:H-Reflex; D018475:Head-Down Tilt; D006801:Humans; D007103:Immobilization; D007537:Isometric Contraction / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*