Immunotherapy of insulin-dependent diabetes mellitus.
Immunotherapy of diabetes is now focusing on induction of tolerance to beta cell antigens using either soluble antigens or monoclonal anti-T-cell antibodies. These approaches have reached the clinical arena. At the experimental level, strategies are being developed that use or target cytokines (with gene therapy) or stimulate regulatory T cells.
Bach
J F
JF
Institut National de la Santé et de la Recherche Médicale (INSERM) U 25, Hôpital Necker, 161 Rue de Sèvres, 75743 Cedex 15, Paris, France. bach@necker.fr
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000639:trends