title: Spontaneous regression of osteosarcoma in four dogs.
abstract: Spontaneous regression of primary malignant bone tumors is rare but has been reported in the human literature. To the authors' knowledge, spontaneous regression of primary bone tumors in dogs or cats has not been reported. Osteosarcoma (OSA) is the most common primary bone tumor in humans, and it has been reported that the incidence of OSA is 40 to 50 times greater in dogs than humans. In this report, high-grade OSA was diagnosed in biopsy specimens obtained from 4 dogs that subsequently underwent spontaneous regression without tumor-specific treatment. Osteosarcoma in dogs has characteristics similar to that of OSA in humans.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Mehl
authors.forename: S J
authors.initials: SJ
authors.lastname: Withrow
authors.forename: B
authors.initials: B
authors.lastname: Seguin
authors.forename: B E
authors.initials: BE
authors.lastname: Powers
authors.forename: W S
authors.initials: WS
authors.lastname: Dernell
authors.forename: A D
authors.initials: AD
authors.lastname: Pardo
authors.forename: R C
authors.initials: RC
authors.lastname: Rosenthal
authors.forename: S Z
authors.initials: SZ
authors.lastname: Dolginow
authors.forename: R D
authors.initials: RD
authors.lastname: Park
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D005260:Female; D007794:Lameness, Animal / Q000175:diagnosis*; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D012516:Osteosarcoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*