A case of agranulocytosis associated with severe acute hepatitis B.
A 29-year-old male patient with acute hepatitis B developed agranulocytosis about 2 months after the clinical onset of the hepatitis. Bone marrow examination showed hypercellularity and maturation arrest of myeloid leukogenesis at the stage of metamyelocyte. Anti-neutrophil antibody was negative. Since the patient did not show spontaneous recovery for 2 months, the patient received granulocyte-colony stimulating factor, but the therapy was a very short course because he had an elevation of temperature and nausea. Sixty-eight days after admission, he was started on lithium carbonate at a dose of 600 mg per day. About 3 weeks later, peripheral granulocyte counts had recovered to normal level.
Iwamoto
J -i.
J
The Department of Internal Medicine, Japan Self Defense Forces Central Hospital, 1-2-24 Ikejiri Setagaya-ku, Tokyo, Japan
Hakozaki
Y
Y
Sakuta
H
H
Kobari
S -i.
S
Kayashima
S
S
Fujioka
T
T
Ooba
K -i.
K
Shirahama
T
T