title: [Antioxidant properties of 3-oxypyridine analogues: mexidol, emoxipin, proxipin].
abstract: Using three chemiluminescent model systems of oxidation (suspension of phospholipid liposomes, a geous solution of haemoglobin-hydrogen peroxide-luminol and a geous solution 2,2'-azo-bis-(2-methylpropionamidine)dihydrochloride-luminol) the antioxidant activity and mechanism of antioxidant action of three 3-oxypyridine analogues: (mexidol, emoxipin and proxipin) were studied. These compounds were shown: a) to interact with catalitically active two valency iron ions (Fe2+), that causes elimination of ions from the model system; b) to scavenge reactive oxygen species and/or luminol radicals produced in the model systems. Their activity reduced in the following order: mexidol > emoxipin > proxipin. The antioxidant activity of 3-oxypyridines may underline known clinical effects of these compounds.
authors.affiliation: Department of Biophysic, Russian State Medical University, Ostrovityanova ul. 1, Moskow, 119869, Russia. klebanov@fbm.msu.ru
authors.forename: G I
authors.initials: GI
authors.lastname: Klebanov
authors.forename: O B
authors.initials: OB
authors.lastname: Liubitskiĭ
authors.forename: O V
authors.initials: OV
authors.lastname: Vasil'eva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Klimov
authors.forename: O B
authors.initials: OB
authors.lastname: Penzulaeva
authors.forename: A S
authors.initials: AS
authors.lastname: Tepliashin
authors.forename: M P
authors.initials: MP
authors.lastname: Tolstykh
authors.forename: V K
authors.initials: VK
authors.lastname: Promorenko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Vladimirov
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation; D010847:Picolines / Q000737:chemistry / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism*; D017382:Reactive Oxygen Species
chemical_list: D000975:Antioxidants; D010847:Picolines; D011725:Pyridines; D017382:Reactive Oxygen Species; C014047:hydroxypyridines; C070020:emoxypine succinate; D007501:Iron; C009820:6-methyl-2-ethyl-3-hydroxypyridine