Current status of surgery for carcinoma of the hypopharynx and cervical esophagus.
Hypopharynx and cervical esophagus represent a critical location for a squamous cell carcinoma, a neoplasm that usually requires extensive surgery. Although morbidity and mortality of resection have markedly decreased over the past decade, the major issue in these patients remains quality of life owing to the need for combination with a laryngectomy to provide radical treatment. Chemoradiation therapy has the potential to downstage and even cure the disease without altering quality of life dramatically. Today, in the absence of randomized trials, the choice between surgery and definitive chemoradiotherapy should be based on clear information and the patient's preference. Salvage surgery is feasible and effective in selected patients.
Peracchia
A
A
Department of Surgery, University of Milan, Ospedale Maggiore Policlinico IRCCS, Milano, Italy. alberto.peracchia@unimi.it
Bonavina
L
L
Botturi
M
M
Pagani
M
M
Via
A
A
Saino
G
G
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D006801:Humans; D007013:Hypopharynx / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D011183:Postoperative Complications; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate