title: Electrical impedance measurements in the arm and the leg during a thirty day bed rest study.
abstract: The need to detect, follow and understand the effects of gravity on body fluid distribution is a constant stimulus to the quest for new techniques in this area of research.  One of these techniques is electrical bioimpedance spectroscopy (BIS).  Although not new, this is a technique whose applications to biomedical research are fairly recent.  What is new is the development of instrumentation that has made practical the use of impedance spectroscopy in the biomedical setting, particularly in studies involving human subjects.  The purpose of this paper is to report impedance spectroscopy observations made on a subject who was submitted to bed rest for a period of thirty days.  These observations were made as part of a study on muscle atrophy during a thirty day head down bed rest.  Since bed rest studies are very costly in human and financial terms, and technically difficult to realize, we felt that even though the present study deals only with a single case it was worthy of reporting because it illustrates kinds of questions impedance spectroscopy may help to answer in microgravity research.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: D
authors.initials: D
authors.lastname: Cardús
authors.forename: M
authors.initials: M
authors.lastname: Jaweed
authors.forename: W
authors.initials: W
authors.lastname: McTaggart
mesh_terms: D000328:Adult; D001132:Arm / Q000502:physiology; D001510:Bed Rest / Q000009:adverse effects*; D001823:Body Composition; D002462:Cell Membrane / Q000502:physiology; D017097:Electric Impedance; D005110:Extracellular Space / Q000502:physiology*; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology*; D007866:Leg / Q000502:physiology; D008297:Male