[Virulence factor expression regulation in Listeria monocytogenes].
The external and internal factors affecting the expression of L. monocytogenes virulence genes are analyzed. The role of protein PrfA, the only known factor directly affecting the transcription of virulence genes, as well as the contribution of other regulatory elements modulating the activity and/or intracellular concentration of PrfA are discussed. The environmental factors which influence the level of expression, such as temperature and the presence of metabolized carbohydrates in the cultivation medium, are analyzed. In addition, the possibility of autoregulating processes (the accumulation of L. monocytogenes-secreted autorepressor in the medium) is discussed and the possible mechanism of their action is suggested.
Ermolaeva
S A
SA
Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Tartakovskiĭ
I S
IS
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008089:Listeria monocytogenes / Q000378:metabolism / Q000472:pathogenicity*; D010454:Peptide Termination Factors; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D010454:Peptide Termination Factors; D015534:Trans-Activators