title: [The relation between the clinical symptoms and the findings on magnetic resonance in children with periventricular leukomalacia].
abstract: OBJECTIVE
  To assess whether there is a relationship between the various clinical symptoms and imaging findings on MR in children with periventricular leukomalacia (PVLM).
  
  
  METHODS
  We made a retrospective study of 41 consecutive paediatric patients, 19 boys and 22 girls, with an average age of 30.5+/-19 months (range 8 84 months) who had been diagnosed as having PVLM and studied using MR, recording imaging, clinical and epidemiological data.
  
  
  RESULTS
  The MR images showed areas of gliosis in all the children (few foci in 68.3% and multiple foci in 31.7%), with cysts in 22%. The changes were seen mainly in the parietal and occipital regions, were bilateral and symmetrical in 80.5%, with ventricular dilatation in 75.6%, atrophy of the parenchyma in 48.8%, Wallerian degeneration in 7.3%, delay in myelination in 31.7%, lesions in the optic radiations in 9.8%, thalamus 12.2% and anomalous venous drainage in 2.4%. The overall degree of involvement on MR was severe in 43.9%, moderate in 31,7% and mild in 24.4%. There was a history of perinatal foetal distress in 56.8%, hyaline membrane disease in 40.5%, intracranial hemorrhage in 35.1%, psychomotor retardation in 58.5%, motor retardation in 29.3%, and squint in 22%. A significant relationship was found only between acute foetal distress and lateralization of the lesions (p= 0.038) and the presence of parenchymatous cysts (p= 0.024).
  
  
  CONCLUSIONS
  The patients with a history of foetal distress had a greater tendency to symmetrical, bilateral involvement with cysts in the white matter of the brain. It was not possible to establish a model for classification of the overall involvement using MR and the data recorded. The imaging findings were not related overall to the patients symptoms.
authors.affiliation: Servicio de Radiodiagnóstico; Clínica Quirón, Valencia, 46010, España. marti_lui@gva.es
authors.forename: L
authors.initials: L
authors.lastname: Martí-Bonmatí
authors.forename: C
authors.initials: C
authors.lastname: Rodrigo
authors.forename: A
authors.initials: A
authors.lastname: Torregrosa
authors.forename: F
authors.initials: F
authors.lastname: Menor
authors.forename: R
authors.initials: R
authors.lastname: Dosdá
authors.forename: C
authors.initials: C
authors.lastname: Poyatos
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male