title: Coupling reactions of cephalosporin sulfones: a stable 3-stannylated cephem.
abstract: The first stable 3-metalated cephalosporin is reported and shown to be an excellent synthetic precursor to a number of prospective beta-lactamase inhibitors. Reaction: see text.
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, Texas 75275-0314, USA. jbuynak@mail.smu.edu
authors.forename: J D
authors.initials: JD
authors.lastname: Buynak
authors.forename: L
authors.initials: L
authors.lastname: Vogeti
authors.forename: H
authors.initials: H
authors.lastname: Chen
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D004355:Drug Stability; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry; D018440:beta-Lactam Resistance; D065093:beta-Lactamase Inhibitors
chemical_list: C449321:3-stannylated cephem; D000890:Anti-Infective Agents; D002511:Cephalosporins; D004791:Enzyme Inhibitors; D009947:Organotin Compounds; D011725:Pyridines; D013450:Sulfones; D065093:beta-Lactamase Inhibitors