Genetic hemochromatosis is a rare disease entity among French Basques: a center-based study from the general hospital of Basque County.
A center-based study from the general hospital of Basque country has been performed to evaluate the importance of genetic hemochromatosis among French Basques. A sample of 37 patients from 34 families fulfilling the diagnosis criteria of hemochromatosis was obtained. Only four of them were of Basque origin: two homozygotes for C282Y, one homozygote for H63D, and one heterozygote for C282Y. These results suggest a significant lower prevalence of genetic hemochromatosis in Basques than in people from other French regions (P=0.001). They underline further the biological specificity of this population.
Bauduer
F
F
Service d'Hématologie, Centre Hospitalier de la Côte Basque, Bayonne, France.
Scribans
C
C
Renoux
M
M
Borot
N
N
D000328:Adult; D000368:Aged; D005260:Female; D005602:France / Q000208:ethnology; D005828:Genetics, Population; D006432:Hemochromatosis / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009154:Mutation