title: Decreased platelet [3H]paroxetine binding sites in suicide attempters.
abstract: Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([3H]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [3H]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior.
authors.affiliation: Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, via Roma, 67, 56100, Pisa, Italy. dmarazzi@psico.med.unipi.it
authors.forename: D
authors.initials: D
authors.lastname: Marazziti
authors.forename: L
authors.initials: L
authors.lastname: Dell'Osso
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: I
authors.initials: I
authors.lastname: Masala
authors.forename: S
authors.initials: S
authors.lastname: Baroni
authors.forename: A
authors.initials: A
authors.lastname: Armani
authors.forename: G
authors.initials: G
authors.lastname: Giannaccini
authors.forename: E
authors.initials: E
authors.lastname: Di Nasso
authors.forename: A
authors.initials: A
authors.lastname: Lucacchini
authors.forename: G B
authors.initials: GB
authors.lastname: Cassano
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000503:physiopathology / Q000523:psychology; D002352:Carrier Proteins / Q000097:blood* / Q000502:physiology*; D015897:Comorbidity; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000503:physiopathology / Q000523:psychology; D008875:Middle Aged; D017374:Paroxetine / Q000493:pharmacokinetics; D011869:Radioligand Assay; D011955:Receptors, Drug / Q000097:blood*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins; D013406:Suicide, Attempted / Q000523:psychology*
chemical_list: D002352:Carrier Proteins; D011955:Receptors, Drug; D050486:Serotonin Plasma Membrane Transport Proteins; C092604:paroxetine receptor; D017374:Paroxetine