title: Subfrontal schwannoma masquerading as meningioma.
abstract: Intracranial schwannomas not associated with cranial nerves are rare and seldom encountered in the subfrontal region. We report a case of subfrontal schwannoma in a 21-year-old man who presented with seizures. Radiological features resembled an olfactory groove meningioma. The histological diagnosis of schwannoma was confirmed by immunohistochemical staining with S-100 and electron microscopy. We advocate the use of immunohistochemistry and electron microscopy as adjuncts to conventional light microscopy in differentiating schwannomas from meningiomas. Surgery remains the main therapeutic modality and complete excision is associated with cure.
authors.affiliation: Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong, China.
authors.forename: T C
authors.initials: TC
authors.lastname: Tan
authors.forename: L C
authors.initials: LC
authors.lastname: Ho
authors.forename: H M
authors.initials: HM
authors.lastname: Chiu
authors.forename: S C
authors.initials: SC
authors.lastname: Leung
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008854:Microscopy, Electron; D009442:Neurilemmoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D012640:Seizures / Q000209:etiology
chemical_list: D009418:S100 Proteins