title: Experimental models to investigate the pathology of antisperm antibodies: approaches and problems.
abstract: Antisperm antibodies (ASA) can interfere with sperm function and fertilization. But we still know relatively little about the specific mechanisms that elicit an auto-immune response and we have a poor appreciation of the profile of ASA that lead to antibody-mediated infertility in the male. This brief review explores some of the experimental models, the current approaches and the problems associated with investigations of ASA.
authors.affiliation: Department of Molecular Biology & Biotechnology, University of Sheffield, UK
authors.forename: R
authors.initials: R
authors.lastname: Clayton
authors.forename: H
authors.initials: H
authors.lastname: Moore
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000502:physiology*; D004195:Disease Models, Animal; D005306:Fertilization; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000276:immunology*
chemical_list: D001323:Autoantibodies