Immunoglobulin GM and KM allotypes in systemic lupus erythematosus.
Genetic variation in immunoglobulin gamma (GM) and kappa (KM) chains was associated with systemic lupus erythematosus (SLE) in some studies. However, the data are conflicting, and only one study examined associations in African-Americans. We examined GM and KM allotypes, by race, in a population-based case-control study of SLE. Sera from patients (n = 222) and controls (n = 273) were typed for GM and KM allotypes by a hemagglutination inhibition method. GM phenotypes were not significantly associated with SLE in African-Americans or Caucasians. However, the frequency of KM phenotypes in Caucasian patients was significantly different from that in controls (p = 0.032). KM3,3 was associated with an increased risk, whereas KM1,3 was associated with a lower relative risk of SLE. In African-Americans, however, the pattern of associations with KM phenotypes differed from that in Caucasians, and the overall difference between patients and controls was not statistically significant.
Pandey
J P
JP
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425-2230, USA. pandeyj@musc.edu
Cooper
G S
GS
Treadwell
E L
EL
Gilkeson
G S
GS
St  Clair
E W
EW
Dooley
M A
MA
D000293:Adolescent; D000328:Adult; D044383:Black People / Q000235:genetics; D005260:Female; D006801:Humans; D007125:Immunogenetics; D007126:Immunoglobulin Allotypes / Q000235:genetics* / Q000276:immunology*; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008297:Male; D010641:Phenotype; D044465:White People / Q000235:genetics; D001741:Black or African American
D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes