Modified cyclobutane carbonucleosides: synthesis and evaluation of their antiviral activity.
The synthesis of some 9-(2-cyclobutylethyl)guanine derivatives and analogous carbonucleosides from 1S-alpha-pinene is here presented. None of them showed detectable selectivity when assayed in the performed anti-viral tests.
Fernández
F
F
Dpto. Química Orgánica, Facultad de Farmacia, Universidad de Santiago, E-15706 Santiago de Compostela, Spain.
Hergueta
A R
AR
López
C
C
De Clercq
E
E
Balzarini
J
J
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000998:Antiviral Agents; D003503:Cyclobutanes; D009705:Nucleosides