Comparison of efficacy of ginger with various antimotion sickness drugs.
Ginger and several other medications were compared with scopolamine and d-amphetamine for effectiveness in prevention of motion sickness.


METHODS
Double-blind techniques were used.  The subjects were given the medications two hours before they were rotated in a chair making head movements until a symptom total short of vomiting was reached.  Standardized N.A.S.A. techniques were used for speed of rotation and end-point of motion sickness.


RESULTS
The three doses of ginger were all at the placebo level of efficacy.  Amitriptyline, ethopropazine and trihexyphenidyl increased the tolerated head movements but the increase was not statistically significant.  Significant levels of protection were produced by dimenhydrinate, promethazine, scopolamine and d-amphetamine.  Protection was further increased by combination of these latter drugs with d-amphetamine.  Efficacy was greatest as the dose was increased.


CONCLUSIONS
The medication of choice in this study was scopolamine 0.6 mg with d-amphetamine 10 mg.  This combination provided good protection with acceptable side effects.
Wood
C D
CD
Department of Pharmacology and Therapeutics, Louisiana State University Medical Center, Shreveport  71130.
Manno
J E
JE
Wood
M J
MJ
Manno
B R
BR
Mims
M E
ME
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D003913:Dextroamphetamine / Q000627:therapeutic use*; D004111:Dimenhydrinate / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009041:Motion Sickness / Q000188:drug therapy / Q000517:prevention & control*; D010946:Plants, Medicinal / Q000378:metabolism*; D011398:Promethazine / Q000008:administration & dosage / Q000627:therapeutic use; D012399:Rotation; D012601:Scopolamine / Q000008:administration & dosage / Q000627:therapeutic use; D017365:Spices
D000932:Antiemetics; D012601:Scopolamine; D011398:Promethazine; D004111:Dimenhydrinate; D003913:Dextroamphetamine