Synthesis and antiproliferative activity of some 4'-C-hydroxymethyl-alpha- and -beta-D-arabino-pentofuranosyl pyrimidine nucleosides.
A suitably protected 4-C-hydroxymethyl-arabino-pentofuranose was prepared and condensed with the following nucleobases: uracil, 5-fluorouracil and thymine. The corresponding cytosine and 5-fluorocytosine derivatives have also been obtained respectively from the uracil and 5-fluorouracil nucleosides. Separation of the anomeric mixtures followed by deprotection afforded the target compounds that were found to be non-cytotoxic to CCRF-CEM leukemia cells.
Griffon
J F
JF
Southern Research Institute, P.O. Box 55305, Birmingham, Alabama 35255-5305, USA.
Montgomery
J A
JA
Secrist
J A
JA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D010429:Pentoses / Q000138:chemical synthesis* / Q000494:pharmacology*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013941:Thymine / Q000031:analogs & derivatives; D014407:Tumor Cells, Cultured; D014498:Uracil / Q000031:analogs & derivatives
D000970:Antineoplastic Agents; D010429:Pentoses; D011741:Pyrimidine Nucleosides; D014498:Uracil; D013941:Thymine; D005472:Fluorouracil