title: [Selective cytostatic and cytotoxic effects of avermectins].
abstract: A natural avermectin complex, aversectin C, was shown to be capable of exerting selective cytostatic effect. It killed proliferating neuroblastoma B 103 cells but was non-toxic for differentiated cells of this culture. The activity of aversectin C was related neither to activation of the GABA alpha-receptors nor to their blocking and was at a large extent due to the action of avermectin A1, a component of aversectin C.
authors.affiliation: Pharmbiomed Research Centre of Biology, Moscow.
authors.forename: V A
authors.initials: VA
authors.lastname: Driniaev
authors.forename: V A
authors.initials: VA
authors.lastname: Mosin
authors.forename: E B
authors.initials: EB
authors.lastname: Krugliak
authors.forename: T S
authors.initials: TS
authors.lastname: Sterlina
authors.forename: A V
authors.initials: AV
authors.lastname: Viktorov
authors.forename: V G
authors.initials: VG
authors.lastname: Tsyganova
authors.forename: A F
authors.initials: AF
authors.lastname: Korystova
authors.forename: A S
authors.initials: AS
authors.lastname: Grichenko
authors.forename: K I
authors.initials: KI
authors.lastname: Zenchenko
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Kokoz
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology* / Q000633:toxicity; D016923:Cell Death; D002454:Cell Differentiation; D002455:Cell Division; D007559:Ivermectin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D000903:Antibiotics, Antineoplastic; C048324:abamectin; D007559:Ivermectin; C019264:avermectin