[Effect of thiotriazoline on the blood supply and oxygen balance in the brain in models of exposure to general vibration].
Chronic experiments on conscious rabbits with needle electrodes implanted into cortex, thalamus, and hypothalamus were used to study variations in the local blood flow (BF) and the cerebral vessel response to hypercapnia and hyperoxia by method of hydrogen clearance. Variations of the partial oxygen pressure (PO2) in the tissues of these structures was measured by the polarographic technique. The general vibration action (modeled in a special testing device) decreased the local BF in the cortex and hipothalamus, suppressed the response of cerebral vessel (especially of the constrictor ones) to hyperoxia, and reduced PO2 in all the structures studied. Acting upon the neuron energy exchange and reducing their oxygen consumption, thiotriazolin prevented the drop in PO2 and even increased this parameter, while not preventing the decrease in BF and the inhibition of vessel response.
Sapegin
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ID
Pharmacology Department, Clinical Immunology and Allergology Department (with Clinical Pharmacology Faculty), Simferopol State Medical University, Lenin bul. 5/7, Simferopol, Crimea, Ukraine.
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects; D007031:Hypothalamus / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D009025:Morpholines / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism*; D011817:Rabbits; D013788:Thalamus / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D014230:Triazoles / Q000494:pharmacology*; D014732:Vibration / Q000009:adverse effects*
D009025:Morpholines; D014230:Triazoles; C435843:morpholinium 3-methyl-1,2,4-triazoline-5-thioacetate; D002245:Carbon Dioxide; D010100:Oxygen