2'-O-modified oligoribonucleotides with terminal 3'-3'-internucleotide linkage and their derivatives.
A high RNA binding affinity and nuclease resistance of 2'-O-modified (2'-O-methyl, 2'-O-tetrahydropyranyl) oligoribonucleotides containing the "inverted" T at the 3'-end have been shown. The synthesis and properties of new photoactivatable perfluoroarylazide derivatives of these oligoribonucleotides are discussed.
Novopashina
D
D
Novosibirsk State University, ul. Pirogova 2, Novosibirsk 630090, Russia.
Kuznetsova
M
M
Venyaminova
A
A
D007700:Kinetics; D020320:Oligoribonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010777:Photochemistry; D012313:RNA / Q000378:metabolism
D020320:Oligoribonucleotides, Antisense; D012313:RNA