[Changes of T-SOD activity and MDA, GSH contents in blood of guinea pigs after exposure to narrow-band noise].
In order to evaluate the changes of lipid peroxide response induced by free radical after intense noise exposure, levels of T-SOD and MDA in serum and GSH in blood of guinea pigs were determined. Sixty male adult guinea pigs were used. The narrow band noise was centered at 1000Hz with 100Hz band width 126 dB SPL. It was found: 1) SOD activity in serum increased after 5d exposure (P > 0.05), but decreased after 10d exposure (P > 0. 05); 2) contents of MDA in serum increased (P < 0.05) and contents of GSH in blood decreased with increase of exposure time (P < 0.01). It shows that the lipid peroxide response induced by free radicals increased after intense noise exposure and it is possible to use free radical scavengers and/or antioxidant in prevention and treatment of noise induced damage.
Shi
X
X
Naval Medical Reseach Institute, Shanghai, China.
Guo
F
F
Liang
Z
Z
Zhu
Q
Q
Yang
Y
Y
D000818:Animals; D016166:Free Radical Scavengers; D005609:Free Radicals; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D006168:Guinea Pigs; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism*; D009622:Noise / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D016166:Free Radical Scavengers; D005609:Free Radicals; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione