title: A selective inhibitor of Escherichia coli prephenate dehydratase.
abstract: To identify selective prephenate dehydratase (PDT) inhibitors, a series of substituted biphenic acid derivatives was synthesized using the Ullmann reaction. Screening experiments identified 18 as a promising new PDT inhibitor.
authors.affiliation: Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
authors.forename: A
authors.initials: A
authors.lastname: Husain
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: D B
authors.initials: DB
authors.lastname: Wilson
authors.forename: B
authors.initials: B
authors.lastname: Ganem
mesh_terms: D002826:Chorismate Mutase / Q000037:antagonists & inhibitors; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology*; D020128:Inhibitory Concentration 50; D009579:Nitrobenzoates / Q000737:chemistry* / Q000494:pharmacology*; D011302:Prephenate Dehydratase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D009579:Nitrobenzoates; D011302:Prephenate Dehydratase; D002826:Chorismate Mutase