Bupivacaine hydrochloride induces muscle fiber necrosis and hydroxyl radical formation-dimethyl sulphoxide reduces hydroxyl radical formation.
We induced acute skeletal muscle necrosis in rats using bupivacaine hydrochloride and found that both 2,5- and 2,3-dihydroxybenzoic acid significantly increased in skeletal muscle. A single administration of dimethyl sulphoxide, a free radical scavenger, significantly lowered concentrations of 2,5- and 2,3-dihydroxybenzoic acid. These results suggest that dimethyl sulphoxide is an effective hydroxyl radical scavenger and may be useful in the treatment of myopathy.
Wakata
N
N
Fourth Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan. waka@oha.toho-u.ac.jp
Sugimoto
H
H
Iguchi
H
H
Nomoto
N
N
Kinoshita
M
M
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002045:Bupivacaine / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000473:pathology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology*; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar
D000779:Anesthetics, Local; D016166:Free Radical Scavengers; D017665:Hydroxyl Radical; D002045:Bupivacaine; D004121:Dimethyl Sulfoxide