A selective inhibitor of Escherichia coli prephenate dehydratase.
To identify selective prephenate dehydratase (PDT) inhibitors, a series of substituted biphenic acid derivatives was synthesized using the Ullmann reaction. Screening experiments identified 18 as a promising new PDT inhibitor.
Husain
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A
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Chen
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S
Wilson
D B
DB
Ganem
B
B
D002826:Chorismate Mutase / Q000037:antagonists & inhibitors; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology*; D020128:Inhibitory Concentration 50; D009579:Nitrobenzoates / Q000737:chemistry* / Q000494:pharmacology*; D011302:Prephenate Dehydratase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D009579:Nitrobenzoates; D011302:Prephenate Dehydratase; D002826:Chorismate Mutase