title: Direct MALDI-TOF MS analysis of oligonucleotides on solid support through a photolabile linker.
abstract: MALDI-TOF mass spectrometry was used to analyze oligonucleotides still anchored to long-chain alkylamine controlled-pore glass (LCAA-CPG) through a photolabile linker. This technique is useful to follow supported chemical reactions in real time and monitor by-products formation.
authors.affiliation: Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM2, Université Montpellier II, Place E. Bataillon, 34095, Montpellier, France.
authors.forename: A
authors.initials: A
authors.lastname: Meyer
authors.forename: N
authors.initials: N
authors.lastname: Spinelli
authors.forename: J C
authors.initials: JC
authors.lastname: Brés
authors.forename: C
authors.initials: C
authors.lastname: Dell'Aquila
authors.forename: F
authors.initials: F
authors.lastname: Morvan
authors.forename: I
authors.initials: I
authors.lastname: Lefebvre
authors.forename: B
authors.initials: B
authors.lastname: Rayner
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
authors.forename: J J
authors.initials: JJ
authors.lastname: Vasseur
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry*; D005898:Glass / Q000737:chemistry; D016376:Oligonucleotides, Antisense / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry; D010777:Photochemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
chemical_list: D003432:Cross-Linking Reagents; D016376:Oligonucleotides, Antisense