title: Brachyspira aalborgi infection in four Australian children.
abstract: OBJECTIVE
  The clinical presentation of four children and adolescents (two males and two females with a mean age of 12.4 years; range 9-16 years) with colorectal spirochetosis is discussed.
  
  
  RESULTS
  Symptoms included persistent diarrhea (n = 2), rectal bleeding (n = 1) and abdominal pain (n = 2). In all patients, colorectal spirochetosis was an unanticipated finding on colonic histology, and the presence of spirochetes was confirmed by the use of electron microscopy. Spirochetes were identified as Brachyspira aalborgi by using PCR amplification of the bacterial 16S rRNA and nicotinamide adenine dinucleotide oxidase sequences in all four patients. No other enteric pathogens were found.
  
  
  CONCLUSIONS
  Although all patients appeared to respond to antibiotic treatment, the clinical significance of B. aalborgi as a human pathogen requires further investigation.
authors.affiliation: Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Melbourne, Victoria, Australia. heiner@cryptic.rch.unimelb.edu.au
authors.forename: R G
authors.initials: RG
authors.lastname: Heine
authors.forename: P B
authors.initials: PB
authors.lastname: Ward
authors.forename: A S
authors.initials: AS
authors.lastname: Mikosza
authors.forename: V
authors.initials: V
authors.lastname: Bennett-Wood
authors.forename: R M
authors.initials: RM
authors.lastname: Robins-Browne
authors.forename: D J
authors.initials: DJ
authors.lastname: Hampson
mesh_terms: D000293:Adolescent; D001315:Australia; D002648:Child; D003106:Colon / Q000382:microbiology* / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D013144:Spirochaetales / Q000187:drug effects / Q000302:isolation & purification* / Q000648:ultrastructure; D013145:Spirochaetales Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology