Phagocyte system under spaceflight conditions.
The spaceflight conditions lead to disturbances in immune system and cause the changes in microbial and chemical environment that create preconditions for immunodeficiency and allergic disease development. With the spaceflights lengthening the problem of crewmembers immunodeficiency and the probability of allergic disease manifestation became actual. The higher risk of various pathological conditions noted in cosmonauts during space flight due to lowered immunological resistance and unnatural biological and chemical environment (autoimmune reactions, bacterial and viral autoinfections, possible allergic events etc.) proves the need of studying the mechanisms of these disturbances and determination the most labile links between the immune system and antigen environment. In this case phagocytes seems to be one of the most important cells that can influence both induction and effector stage of immune reactions and also take part in the regulation of the immune response. The goal of the investigation was to conduct studies of one of the of the phagocytes metabolic and migration activity that are closely connected with functional activity of the cells.
Meshkov
D
D
State Research Center of Russian Federation, Institute for BioMedical Problems.
Rykova
M
M
Antropova
E
E
Vdovin
A
A
Biziukin
A
A
Nesvizhsky
I
I
D000293:Adolescent; D000328:Adult; D000337:Aerospace Medicine; D000368:Aged; D001510:Bed Rest; D002465:Cell Movement / Q000235:genetics / Q000502:physiology; D002648:Child; D005260:Female; D005609:Free Radicals; D018475:Head-Down Tilt; D006801:Humans; D007107:Immune System / Q000502:physiology*; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D018375:Neutrophil Activation / Q000235:genetics / Q000502:physiology; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D010586:Phagocytes / Q000378:metabolism* / Q000502:physiology; D013026:Space Flight; D014893:Weightlessness; D018474:Weightlessness Simulation
D005609:Free Radicals