Mathematical model of the electromechanical heart contractile system--regulatory subsystem physiological considerations.
The biochemical model of excitation-contraction coupling in cardiomyocyte is presented and the validity of simulations of both physiological and pathological processes is discussed. The model of regulatory and actomyosin subsystems, even if it is rather simple in its regulatory subunit, gives results well consistent with experimental data. Specifically, intracellular free calcium levels ([Ca2+]i) were computed under various states of sarcoendoplasmic reticular Ca2+-ATPase (SERCA2) and compared to experimental findings. Computed results reproduced well both the increase in resting [Ca2+]i level and the attenuation of [Ca2+]i decline commonly observed in heart failure. Thus the computational simulations could help to identify core relations in studied systems by comparing results obtained using similar models of various complexities.
Mlcek
M
M
Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic. mikulas.mlcek@lfl.cuni.cz
Neumann
J
J
Kittnar
O
O
Novák
V
V
D000205:Actomyosin / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000378:metabolism / Q000503:physiopathology; D003198:Computer Simulation; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases
D000205:Actomyosin; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; C506946:ATP2A2 protein, human; D000252:Calcium-Transporting ATPases; D002118:Calcium