title: Pro-oligonucleotide synthesis using allyl and allyloxycarbonyl protections: direct MALDI-TOF MS analysis on solid support.
abstract: The solid-support synthesis of pro-oligonucleotide heteropolymer chimeras had been performed with allyloxycarbonyl group (AOC) for the protection of nucleobases and of allyl and S-acetyl-2-thioethyl (MeSATE) for phosphate protections to respectively generate phosphodiester and MeSATE phosphotriester linkages.
authors.affiliation: Lab. de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM2, Université Montpellier II, Place E. Bataillon, 34095, Montpellier, France.
authors.forename: N
authors.initials: N
authors.lastname: Spinelli
authors.forename: J J
authors.initials: JJ
authors.lastname: Vasseur
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
mesh_terms: D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010755:Organophosphates / Q000138:chemical synthesis / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
chemical_list: D009841:Oligonucleotides; D010755:Organophosphates; D009943:Organophosphorus Compounds; D011355:Prodrugs; C434331:phosphoramidite