title: Thoracoscopic lung volume reduction surgery for pulmonary emphysema patients with severe hypercapnia.
abstract: OBJECTIVE
  We assessed whether hypercapnia patients with an extremely high level of PaCO2 > or = 60 mmHg were suitable candidates for lung volume reduction in the treatment of severe pulmonary emphysema.
  
  
  METHODS
  Of 65 patients undergoing lung volume reduction surgery between May 1993 and August 1997, 6 (9.23%) who had a preoperative rest room air blood gas level of PaCO2 > or = 60 mmHg were selected for study. All patients underwent video-assisted thoracoscopic surgery. Of the 6 with severe hypercapnia, 5 underwent the unilateral procedure and 1 the bilateral procedure.
  
  
  RESULTS
  All severe hypercapnia patients showed significant clinical improvement. When assessed at 3 to 6 months after lung volume reduction surgery, significant improvements were seen in mean forced expiratory volume in 1 second (preop: 0.44 +/- 0.04 L; postop: 0.74 +/- 0.20 L; p < 0.01), for a magnitude improvement of 69.8%, and in trapped gas volume (preop: 3.28 +/- 1.11 L; postop: 1.61 +/- 1.02 L; p < 0.05). Arterial blood gas analysis showed significant improvement in PaO2 from 51.1 +/- 6.68 mmHg to 69.8 +/- 7.87 mmHg (p < 0.001) with a decrease in PaCO2 from 70.4 +/- 9.41 mmHg to 46.9 +/- 3.44 mmHg (p < 0.01). Postoperative follow-up averaged 55 months (43-69 months). All but 1 patient remain alive and well.
  
  
  CONCLUSIONS
  Patients with severe pulmonary emphysema accompanied by hypercapnia can gain relief and a better quality of life through volume reduction surgery and should not be excluded from surgical treatment simply based on this condition. Selection should involve a comprehensive view of the patient's condition that includes criteria such as the results of radiographic diagnosis and detailed pulmonary function tests.
authors.affiliation: Second Department of Surgery, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai 980-8574, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mitsui
authors.forename: Y
authors.initials: Y
authors.lastname: Kurokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kaiwa
authors.forename: K
authors.initials: K
authors.lastname: Ando
authors.forename: H
authors.initials: H
authors.lastname: Kurosawa
authors.forename: W
authors.initials: W
authors.lastname: Hida
authors.forename: S
authors.initials: S
authors.lastname: Satomi
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D006935:Hypercapnia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010313:Partial Pressure; D011013:Pneumonectomy / Q000379:methods*; D011656:Pulmonary Emphysema / Q000150:complications / Q000601:surgery*; D020775:Thoracic Surgery, Video-Assisted
chemical_list: D002245:Carbon Dioxide