Fiber size and myosin phenotypes of selected rhesus lower limb muscles after a 14-day spaceflight.
Muscle biopsies were taken from the rhesus (Macaca mulatta) soleus (Sol, a slow ankle extensor), medial gastrocnemius (MG, a fast ankle extensor), tibialis anterior (TA, a fast ankle flexor), and vastus lateralis (VL, a fast knee extensor) muscles in vivarium controls (n=5) before and after either a 14-day spaceflight (Bion 11, n=2) or a 14-day ground-based flight simulation (n=3). Myosin heavy chain (MHC) composition (gel electrophoresis), fiber type distribution (immunohistochemistry), and fiber size were determined. Although there were no significant changes, each muscle showed trends towards adaptation.
Roy
R R
RR
Brain Research Institute, University of California, Los Angeles, USA.
Zhong
H
H
Bodine
S C
SC
Pierotti
D J
DJ
Talmadge
R J
RJ
Barkhoudarian
G
G
Kim
J
J
Fanton
J W
JW
Kozlovskaya
I B
IB
Edgerton
V R
VR
D000818:Animals; D008253:Macaca mulatta; D008297:Male; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism / Q000473:pathology; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D009133:Muscular Atrophy / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D018995:Myosin Heavy Chains / Q000378:metabolism*; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*
D018995:Myosin Heavy Chains