Sensitivity analysis of pharmacodynamic parameters in pharmacodynamic models.
The quantitative properties of a pharmacodynamic model can be characterized by the pharmacodynamic parameters. The sensitivity analysis of pharmacodynamic parameters in eight kinds of pharmacodynamic models was conducted. The sensitivity functions with respect to different pharmacodynamic parameters for these pharmacodynamic models were deduced using the partial derivative. The pharmacodynamic parameters were ranked according to their sensitivity functions.
Wu
G
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Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Mediterranée Aix-Marseille II, France.
D000465:Algorithms; D008954:Models, Biological; D010599:Pharmacokinetics