title: Synthesis and antiviral activity of D- and L-2'-azido-2',3'-dideoxy-4'-thiopyrimidine and purine nucleosides.
abstract: Novel D- and L-2'-azido-2',3'-dideoxy-4'-thionucleosides were synthesized starting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they were found to be only active against HCMV without cytotoxicity up to 100 micrograms/ml.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, Korea.
authors.forename: L S
authors.initials: LS
authors.lastname: Jeong
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: H O
authors.initials: HO
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Yoo
authors.forename: Y H
authors.initials: YH
authors.lastname: Park
authors.forename: S H
authors.initials: SH
authors.lastname: Yeon
authors.forename: M W
authors.initials: MW
authors.lastname: Chun
authors.forename: H D
authors.initials: HD
authors.lastname: Kim
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001386:Azides / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D013237:Stereoisomerism; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014994:Xylose / Q000031:analogs & derivatives
chemical_list: D000998:Antiviral Agents; D001386:Azides; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D013872:Thionucleosides; D014994:Xylose