[Experimental study of radiosensitizing effect of analogs of purines and pyrimidine bases in cultured HeLa cells].
The radio-sensitizing capacity of cultured HeLa cells was investigated by using a number of compounds, which are analogues of purine and pyrimidine bases. Agents (5-fluorouracil, ftorafur, mercaptopyrine) used in chemotherapy for tumors for many years and some compounds (allopurinol and theophylline) that are sterically close to purine and pyrimidine bases and clinically used for various purposes, but have no cytotoxic activity against tumors cells were tested. Fluorouracil was shown to potentiate the action of gamma-radiation when the agent was given used before radiation or used in the concentrations producing no cytotoxic effect. Allopurinol and theophylline do not possess a radio-sensitizing effect. There was a more pronounced radiosensitization in the concurrent use of a double combination of agents and radiation and the greatest cell death rates were observed in the concurrent use of three agents (5-fluorouracil, ftorafur, and methylcytosine) and gamma-radiation.
Pavlov
A S
AS
Kostromina
K N
KN
Parkhomenko
I M
IM
Simakina
E P
EP
Han Youngsoo
D000493:Allopurinol / Q000494:pharmacology*; D000963:Antimetabolites / Q000494:pharmacology*; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D002470:Cell Survival; D003037:Cobalt Radioisotopes / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology*; D005720:Gamma Rays; D006367:HeLa Cells / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007928:Lethal Dose 50; D015122:Mercaptopurine / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents; D011878:Radiotherapy; D011879:Radiotherapy Dosage; D005641:Tegafur / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology*
D000963:Antimetabolites; D000964:Antimetabolites, Antineoplastic; D003037:Cobalt Radioisotopes; D010726:Phosphodiesterase Inhibitors; D011838:Radiation-Sensitizing Agents; D005641:Tegafur; D000493:Allopurinol; D013806:Theophylline; D015122:Mercaptopurine; D005472:Fluorouracil