title: Novel frameworks as a source of high-affinity ligands.
abstract: The past year has seen further maturation of the techniques used to display populations of proteins and peptides and to select members with desired properties. Many protein domains have now been displayed on genetic packages, diverse populations have been made, and binders with specific useful properties have been selected. Affinity maturation has been demonstrated so that binding in the low nanomolar to subnanomolar range by non-antibodies is now achievable.
authors.affiliation: Dyax Corp, One Kendall Square, Building 600, Suite 623, Cambridge, MA 02139, USA. bladner@dyax.com
authors.forename: R C
authors.initials: RC
authors.lastname: Ladner
authors.forename: A C
authors.initials: AC
authors.lastname: Ley
mesh_terms: D001665:Binding Sites / Q000502:physiology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004355:Drug Stability; D008024:Ligands; D019151:Peptide Library; D010455:Peptides / Q000235:genetics* / Q000378:metabolism; D015202:Protein Engineering / Q000379:methods; D011506:Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D008024:Ligands; D019151:Peptide Library; D010455:Peptides; D011506:Proteins