title: Time to discontinuation of the first highly active antiretroviral therapy regimen: a comparison between protease inhibitor- and non-nucleoside reverse transcriptase inhibitor-containing regimens.
abstract: Data from a cohort of HIV-positive individuals who were antiretroviral naive at enrollment were analysed to estimate the probability of discontinuing the first highly active antiretroviral therapy (HAART) regimen, comparing protease inhibitor- and non-nucleoside reverse transcriptase-containing regimens. Of the 2002 individuals who began HAART, 857 (42.8%) discontinued their first regimen. No statistically significant difference was found in the time to discontinuation by specific type of regimen, either when considered overall or by specific reason.
authors.affiliation: Istituto Superiore di Sanità, Reparto AIDS/MST, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Dorrucci
authors.forename: P
authors.initials: P
authors.lastname: Pezzotti
authors.forename: B
authors.initials: B
authors.lastname: Grisorio
authors.forename: C
authors.initials: C
authors.lastname: Minardi
authors.forename: M S
authors.initials: MS
authors.lastname: Muro
authors.forename: V
authors.initials: V
authors.lastname: Vullo
authors.forename: A
authors.initials: A
authors.lastname: Monforte
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D004334:Drug Administration Schedule; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011480:Protease Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D011480:Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors