Meningitis in infancy in England and Wales: follow up at age 5 years.
OBJECTIVE
To describe important sequelae occurring among a cohort of children aged 5 years who had had meningitis during the first year of life and who had been identified by a prospective national study of meningitis in infancy in England and Wales between 1985 and 1987.


METHODS
Follow up questionnaires asking about the children's health and development were sent to general practitioners and parents of the children and to parents of matched controls. The organism that caused the infection and age at infection were also recorded.


METHODS
England and Wales.


METHODS
General practitioners and parents of children who had had meningitis before the age of 1 year and of matched controls.


METHODS
The prevalence of health and developmental problems and overall disability among children who had had meningitis compared with controls.


RESULTS
Altogether, 1584 of 1717 (92.2%) children who had had meningitis and 1391 of 1485 (93.6%) controls were successfully followed up. Among children who survived to age 5 years 247 of 1584 (15.6%) had a disability; there was a 10-fold increase in the risk of severe or moderate disability at 5 years of age among children who had had meningitis (relative risk 10.3, 95% confidence interval 6.7 to 16.0, P<0.001). There was considerable variation in the rates of severe or moderate disability in children infected with different organisms.


CONCLUSIONS
The long term consequences of having meningitis during the first year of life are significant: 32 of 1717 (1.8%) children died within five years. Not only did almost a fifth of children with meningitis have a permanent, severe or moderately severe disability, but subtle deficits were also more prevalent.
Bedford
H
H
Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH. h.bedford@ich.ucl.ac.uk
de Louvois
J
J
Halket
S
S
Peckham
C
C
Hurley
R
R
Harvey
D
D
D000367:Age Factors; D016022:Case-Control Studies; D002653:Child Behavior Disorders / Q000382:microbiology; D002658:Developmental Disabilities / Q000382:microbiology*; D005128:Eye Diseases / Q000382:microbiology; D005500:Follow-Up Studies; D006311:Hearing Disorders / Q000382:microbiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007805:Language Development Disorders / Q000382:microbiology; D007859:Learning Disabilities / Q000382:microbiology; D016920:Meningitis, Bacterial / Q000150:complications*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D013064:Speech Disorders / Q000382:microbiology; D014786:Vision Disorders / Q000382:microbiology