[Relation between mexidol glucuronide conjugation and characteristics of its therapeutic effect in patients with organic lesions in the central nervous system].
The clinico-pharmacological and pharmacokinetic investigation of mexidole administered in patients with organic CNS damage showed for the first time that there is a correlation between intensity of the drug--glucurone conjugation and the parameters of psychopathological symptom expression and the individual patient state estimation before treatment and upon a single administration or a course of mexidole therapy. This correlation allows the clinico-pharmacological effects and the therapeutic efficacy of mexidole to be predicted based on the drug metabolism index.
Sariev
A K
AK
Laboratory of Pharmacokinetics, Laboratory of Clinical Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Davydova
I A
IA
Neznamov
G G
GG
Zherdev
V P
VP
Teleshova
E S
ES
D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D005260:Female; D020719:Glucuronides / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010847:Picolines / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use*
D020719:Glucuronides; D010847:Picolines; D011619:Psychotropic Drugs; C070020:emoxypine succinate