Absence of association between the allele coding methionine at position 29 in the N-terminal domain of ICAM-1 (ICAM-1(Kilifi)) and severe malaria in the northwest of Thailand.
Intercellular adhesion molecule 1 (ICAM-1) is known to be the endothelial receptor for Plasmodium falciparum-infected erythrocytes. Associations of the variant allele coding methionine at position 29 in the N-terminal domain of ICAM-1, ICAM-1(Kilifi), with severe malaria have been investigated in African populations, and the results of these investigations have varied widely. In this study, we investigated a possible association between the ICAM-1(Kilifi) and severe malaria in adult malaria patients living in northwest Thailand. The frequencies of the ICAM-1(Kilifi) among patients with mild malaria, with non-cerebral severe malaria, and with cerebral malaria were 1.7%, 2.7%, and 2.3%, respectively. This variant showed neither positive nor negative association with severe malaria in Thailand.
Ohashi
J
J
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. juno@m.u-tokyo.ac.jp
Naka
I
I
Patarapotikul
J
J
Hananantachai
H
H
Looareesuwan
S
S
Tokunaga
K
K
D000293:Adolescent; D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D001665:Binding Sites; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008239:Lysine / Q000235:genetics; D016778:Malaria, Falciparum / Q000453:epidemiology* / Q000235:genetics*; D008715:Methionine / Q000235:genetics; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics; D047889:Receptors, Tumor Necrosis Factor, Type II; D013785:Thailand / Q000453:epidemiology
D015703:Antigens, CD; D018124:Receptors, Tumor Necrosis Factor; D047889:Receptors, Tumor Necrosis Factor, Type II; D018799:Intercellular Adhesion Molecule-1; D008715:Methionine; D008239:Lysine