title: Bioactive compounds from Iostephane heterophylla (Asteraceae).
abstract: The novel bisabolene sesquiterpenes 3-6, were isolated from Iostephane heterophylla, using bioguided fractionation. The new compounds were determined to be (12R/12S)-12,13-epoxy-xanthorrhizols (3,4) and (12R/12S)-12,13-dihydro-12,13-dihydroxy-xanthorrizols (5,6) and their structures were characterized by analysis of spectroscopic data and by chemical correlation from xanthorrhizol (2). The stereochemistry at C-12 of 5 was deduced using the modified Mosher experiment. Some of the isolated compounds elicited activity against gram positive and gram negative bacteria, levadura and dermatophytes.
authors.affiliation: Departamento de Farmacia, Conjunto E de la Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán 04510, México, D.F.
authors.forename: M I
authors.initials: MI
authors.lastname: Aguilar
authors.forename: G
authors.initials: G
authors.lastname: Delgado
authors.forename: M L
authors.initials: ML
authors.lastname: Hernández
authors.forename: M L
authors.initials: ML
authors.lastname: Villarreal
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D013293:Enterococcus faecalis / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D008800:Mexico; D008864:Microsporum / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011513:Proteus mirabilis / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects
chemical_list: C445130:12,13-dihydro-12,13-dihydroxy-xanthorrizol; C445129:12,13-epoxy-xanthorrhizol; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D006027:Glycosides; D012717:Sesquiterpenes