Synthesis and antiviral activity of novel exomethylene cyclopropyl nucleosides.
Novel cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5, prepared from Feist's acid 1 was condensed with purine derivatives by the SN2 type reaction. All the synthesized compounds were evaluated for antiviral activity.
Choi
B G
BG
Department of Medicinal Chemistry, College of Pharmacy, Chonnam National University, Kwangju 500-757, Korea.
Kwak
E Y
EY
Hong
J H
JH
Lee
C K
CK
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D006838:Hydrocarbons; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000998:Antiviral Agents; D003521:Cyclopropanes; D006838:Hydrocarbons; D011684:Purine Nucleosides; C030011:carbene; C030797:cyclopropane; D008697:Methane