[Selective cytostatic and cytotoxic effects of avermectins].
A natural avermectin complex, aversectin C, was shown to be capable of exerting selective cytostatic effect. It killed proliferating neuroblastoma B 103 cells but was non-toxic for differentiated cells of this culture. The activity of aversectin C was related neither to activation of the GABA alpha-receptors nor to their blocking and was at a large extent due to the action of avermectin A1, a component of aversectin C.
Driniaev
V A
VA
Pharmbiomed Research Centre of Biology, Moscow.
Mosin
V A
VA
Krugliak
E B
EB
Sterlina
T S
TS
Viktorov
A V
AV
Tsyganova
V G
VG
Korystova
A F
AF
Grichenko
A S
AS
Zenchenko
K I
KI
Kokoz
Iu M
IuM
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology* / Q000633:toxicity; D016923:Cell Death; D002454:Cell Differentiation; D002455:Cell Division; D007559:Ivermectin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; C048324:abamectin; D007559:Ivermectin; C019264:avermectin