[Effect of estradiol and testosterone on learning and behavior in castrated rats of both sex].
The aim of the study was investigation of learning ability and behavior in gonadectomized (GE) male rats after estradiol dipropionate treatment and in ovariectomized (OV) female rats after testosterone proprionate treatment. Learning of the animals was assessed in active and passive avoidance tasks, the behavior was evaluated in the "open field test". The data suggest that estradiol dipropionate in the GE male rats accelerated acquisition and considerably delayed the extinction of active avoidance but depressed many behavioral reactions; testosterone propionate in the OV female rats restored formation of passive and active avoidance partly and increased horizontal motor activity.
Fedotova
Iu O
IuO
Sapronov
N S
NS
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D004958:Estradiol