title: Gravitational biology and the mammalian circadian timing system.
abstract: Mammals have evolved under the influence of many selective pressures.  Two of these pressures have been the static force of gravity and the daily variations in the environment due to the rotation of the earth.  It is now clear that each of these pressures has led to specific adaptations which influence how organisms respond to changes in either gravity or daily time cues.  However, several unpredicted responses to altered gravitational environments occur within the homeostatic and circadian control systems.  These results may be particularly relevant to biological and medical issues related to spaceflight.  This paper demonstrates that the homeostatic regulation of rat body temperature, heart rate, and activity become depressed following exposure to a 2 G hyperdynamic field, and recovers within 5-6 days.  In addition, the circadian rhythms of these same variables exhibit a depression of rhythm amplitude;  however, recovery required a minimum of 7 days.
authors.affiliation: Department of Animal Physiology, University of California, Davis 95616, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Fuller
authors.forename: D M
authors.initials: DM
authors.lastname: Murakami
authors.forename: F M
authors.initials: FM
authors.lastname: Sulzman
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002498:Centrifugation; D002940:Circadian Rhythm / Q000502:physiology*; D006112:Gravitation; D006706:Homeostasis / Q000502:physiology*; D018471:Hypergravity; D008253:Macaca mulatta; D008254:Macaca nemestrina; D051381:Rats; D013026:Space Flight; D014893:Weightlessness