title: Amphiphilic beta-sheet peptides can bind to double and triple stranded DNA.
abstract: It was shown that synthetic peptides with amphiphilic beta-sheet structure can bind to and stabilize double and triple stranded DNA. CD spectra indicated that beta-sheet conformation of peptides were emphasized in the presence or absence of DNA and that no significant change of DNA conformation occurred. UV melting study at pH 7.0 revealed that interaction of peptides with DNA and its hybrids are sensitive and specific depending the host structure.
authors.affiliation: Department of Chemistry, School of Engineering, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: M
authors.initials: M
authors.lastname: Fujii
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D004355:Drug Stability; D006096:Gramicidin / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: C051802:triplex DNA; D006096:Gramicidin; D004247:DNA