The MOX/SUC precursor strategies: robust ways to construct functionalized oligonucleotides.
The use of phosphoramidites bearing one or more methoxyoxalamido (MOX) or succinimido (SUC) reactive groups for construction of functionalized oligonucleotides is described. The efficiency of the new precursor strategy was demonstrated in the synthesis of oligonucleotide containing up to 16 imidazole residues.
Polushin
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Fidelity Systems, Inc., Gaithersburg, Maryland, USA.
D009841:Oligonucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000737:chemistry; D010072:Oxamic Acid / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*
D009841:Oligonucleotides; D009943:Organophosphorus Compounds; D013388:Succinimides; C434331:phosphoramidite; D010072:Oxamic Acid