title: Base excision repair of mitochondrial DNA damage in mammalian cells.
abstract: This review of the work from our laboratory describes initial studies in which base excision repair in mtDNA was first seen. It considers the results of experiments in which the substrates for mtDNA repair were identified. The discussion then focuses on studies during which the sequence context for mtDNA damage and repair were explored. Next, it addresses factors that have been identified that influence mtDNA repair. Finally, it summarizes the results of studies that evaluated cell-specific differences in the repair of mtDNA and explored some of the biological consequences of these differences.
authors.affiliation: Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama 36688, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: LeDoux
authors.forename: G L
authors.initials: GL
authors.lastname: Wilson
mesh_terms: D000478:Alkylation; D000818:Animals; D001761:Bleomycin / Q000633:toxicity; D016466:CHO Cells; D020169:Caspases / Q000378:metabolism; D002525:Cerebellar Cortex / Q000166:cytology; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D011088:DNA Ligases / Q000502:physiology*; D004260:DNA Repair; D004272:DNA, Mitochondrial / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism / Q000528:radiation effects; D004273:DNA, Neoplasm / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D007340:Insulinoma / Q000473:pathology; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009153:Mutagens / Q000633:toxicity; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000633:toxicity; D016877:Oxidants / Q000633:toxicity; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010190:Pancreatic Neoplasms / Q000473:pathology; D016133:Polymerase Chain Reaction; D011740:Pyrimidine Dimers / Q000378:metabolism; D017382:Reactive Oxygen Species; D014466:Ultraviolet Rays / Q000009:adverse effects; D024483:Vitamin K 3 / Q000633:toxicity; D014983:Xeroderma Pigmentosum / Q000235:genetics / Q000473:pathology
chemical_list: D004272:DNA, Mitochondrial; D004273:DNA, Neoplasm; D009153:Mutagens; D016877:Oxidants; D011740:Pyrimidine Dimers; D017382:Reactive Oxygen Species; D001761:Bleomycin; D009569:Nitric Oxide; D024483:Vitamin K 3; D020169:Caspases; D011088:DNA Ligases