title: [Osteoporosis in all young daughters of a mother with multiple osteoporotic fractures. A case of familial osteoporosis].
abstract: We herein describe a family whose female members are all osteoporotic: a postmenopausal mother and her three premenopausal daughters. The mother aged 60 presented axial and peripheral fractures, and very low bone mineral density (BMD). She reported that her grandmother had suffered a hip fracture. The eldest daughter aged 30 suffered multiple vertebral fractures during pregnancy and lactation associated with very low BMD. In view of these observations, the other two daughters aged 29 and 27 years respectively were evaluated. BMD was found to be severely diminished according to densitometric values for osteoporosis established by WHO, but they had no history of bone fractures. Probably the strong genetic component in bone mass is responsible for the severely diminished BMD observed in all the women in this family, as well as the occurrence of bone fractures in two of them. To our knowledge, there are no similar reports in the literature. Our results evidence the importance of evaluating bone mass in the offspring of an individual presenting severe osteoporosis, in order to detect family members with low bone mass and at high risk of developing bone fractures.
authors.affiliation: Sección Osteopatías Médicas, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Argentina. osteologia@ciudad.com.ar
authors.forename: M S
authors.initials: MS
authors.lastname: Parisi
authors.forename: A G
authors.initials: AG
authors.lastname: Díaz
authors.forename: M B
authors.initials: MB
authors.lastname: Oliveri
authors.forename: S
authors.initials: S
authors.lastname: Di Gregorio
authors.forename: C A
authors.initials: CA
authors.lastname: Mautalen
mesh_terms: D000328:Adult; D015519:Bone Density; D005190:Family; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009104:Multiple Trauma / Q000209:etiology; D010024:Osteoporosis / Q000150:complications* / Q000235:genetics; D011247:Pregnancy; D012307:Risk Factors