Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome.
Two families are presented in which siblings of children affected with Hallervorden-Spatz syndrome exhibited characteristic cranial magnetic resonance imaging changes before developing clinical features of the disease. Linkage to a major locus on chromosome 20p supported the diagnosis of Hallervorden-Spatz syndrome. In some patients with Hallervorden-Spatz syndrome, iron is radiographically evident before the onset of clinical symptoms.
Hayflick
S J
SJ
Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97201, USA.
Penzien
J M
JM
Michl
W
W
Sharif
U M
UM
Rosman
N P
NP
Wheeler
P G
PG
D000328:Adult; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000235:genetics / Q000473:pathology*; D010375:Pedigree
D007501:Iron