Novel nucleosides with vinyl fluoride or vinyl bromide moiety as open-chain analogs of neplanocin A.
Novel nucleosides with vinyl fluoride and vinyl bromide were designed, synthesized and evaluated their antiviral activities against poliovirus, HSV, HIV, and HBV.
Choi
M H
MH
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
Lee
C K
CK
Jeong
L S
LS
Chun
M W
MW
Kim
H D
HD
D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000737:chemistry* / Q000494:pharmacology
D000998:Antiviral Agents; D009705:Nucleosides; D014753:Vinyl Compounds; C016829:vinyl fluoride; C031096:neplanocin A; C003763:vinyl bromide; D000241:Adenosine