title: In vivo hyperpolarized 129Xe NMR spectroscopy in tumors.
abstract: The first in vivo hyperpolarized 129Xe NMR study in experimental tumors is presented. Hyperpolarized 129Xe was dissolved in solutions, and was injected intratumorally in GH-3 prolactinomas in rats and RIF-1 fibrosarcomas in mice. The 129Xe NMR spectra and apparent spin-lattice relaxation times in the two tumor types present characteristic differences. These differences are discussed in terms of xenon exchange between the carrier medium and the tissue compartments.
authors.affiliation: CRC Clinical Magnetic Resonance Research Group and Physics Department, The Institute of Cancer Research, The Royal Marsden NHS Trust, Button, Surrey, UK.
authors.forename: J
authors.initials: J
authors.lastname: Wolber
authors.forename: D J
authors.initials: DJ
authors.lastname: McIntyre
authors.forename: L M
authors.initials: LM
authors.lastname: Rodrigues
authors.forename: P
authors.initials: P
authors.lastname: Carnochan
authors.forename: J R
authors.initials: JR
authors.lastname: Griffiths
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: A
authors.initials: A
authors.lastname: Bifone
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D005354:Fibrosarcoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D015175:Prolactinoma / Q000175:diagnosis* / Q000473:pathology; D051381:Rats; D011920:Rats, Inbred WF; D014407:Tumor Cells, Cultured / Q000473:pathology; D014979:Xenon Isotopes / Q000493:pharmacokinetics*
chemical_list: D003287:Contrast Media; D014979:Xenon Isotopes