Effect of clonazepam treatment on antipsychotic drug-induced Meige syndrome and changes in plasma levels of GABA, HVA, and MHPG during treatment.
We demonstrated the effect of clonazepam (2 mg/day) on Meige syndrome in two schizophrenic patients under continuous treatment with antipsychotic drugs, and changes in the plasma levels of gamma-aminobutyric acid (GABA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in these cases. The plasma levels of HVA and MHPG during treatment with clonazepam were decreased in the responder, while not changed in the non-responder to clonazepam. A difference between the responder and the non-responder was not found in the plasma GABA levels. These results suggest that hyperactivities of the central dopaminergic and noradrenergic neurones are involved in the pathophysiology of Meige syndrome.
Yoshimura
R
R
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan. yoshi621@med.uoeh-u.ac.jp
Kakihara
S
S
Soya
A
A
Ueda
N
N
Shinkai
K
K
Nakamura
J
J
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002998:Clonazepam / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D008538:Meige Syndrome / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D008734:Methoxyhydroxyphenylglycol / Q000097:blood*; D012562:Schizophrenia, Disorganized / Q000097:blood / Q000188:drug therapy; D012563:Schizophrenia, Paranoid / Q000097:blood / Q000188:drug therapy; D005680:gamma-Aminobutyric Acid / Q000097:blood*
D014150:Antipsychotic Agents; D008734:Methoxyhydroxyphenylglycol; D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D006719:Homovanillic Acid