title: Cardiac arrhythmias in space. Role of vagotonia.
abstract: Rhythm disorders observed in space have always been minor but they are not unfrequent. They include: ventricular or supra-ventricular extrasystoles, nodal arrhythmias, auriculo-ventricular conduction disorders. There are several etiopathogenetic hypotheses: a strict selection must permit its elimination of an underlying heart disease; the potassium deficiency is often advanced but its role is not certain; the role of catecholamines is also discussed; the role of hypervagotony is extensively analysed as great clinical and electro-cardiographic evidence speaks for it. It can induce disorders which are more serious than those observed so far, particularly fibrillation or intermittent atrial flutter; weightlessness itself could partly condition the vagotonic state; and the effects of fluid shifts are also discussed from this point of view. The possible therapies for various atrial, nodal, ventricular disorders are reviewed, with greater detail for vagal atrial arrhythmias.
authors.affiliation: Service de Medecine Aeronautique, Hopital d'Instruction des Armees Dominique Larrey, Versailles, France.
authors.forename: G
authors.initials: G
authors.lastname: Leguay
authors.forename: A
authors.initials: A
authors.lastname: Seigneuric
mesh_terms: D000222:Adaptation, Physiological; D000337:Aerospace Medicine; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000473:pathology; D004837:Epinephrine / Q000378:metabolism; D018495:Fluid Shifts / Q000502:physiology; D006801:Humans; D007008:Hypokalemia; D009638:Norepinephrine / Q000378:metabolism; D011191:Potassium Deficiency; D013026:Space Flight; D014630:Vagus Nerve / Q000503:physiopathology*; D018879:Ventricular Premature Complexes; D014893:Weightlessness / Q000009:adverse effects*
chemical_list: D009638:Norepinephrine; D004837:Epinephrine