[Moot questions and rarely employed means of treatment for severe forms of diphtheria in adults].
The authors of the article consider the issue of employment of some treatment options for the grave forms of diphtheria and complications thereof in adult subjects to be a matter of debate and they report their experience gained with the use of rarely employed but efficient means of remediation. In diphtherial myocarditis concurrent with acute renal failure with a critical uncorrectable decline in myocardial contractility in spite of a progressive necrosis of the renal parenchyma due to an inadequate perfusion and toxic nephrosis an adrenomimetic drug (depamine) is to be prescribed. A ban on administration of glycosides is not to be regarded as a dogma. The question of their prescription needs to be decided on an individual basis with due regard to the duration of the illness, degree of cardiac decompensation, and whether it is conduction/contractility function disorders that prevail. Severe forms of diphtheria, including that complicated by myocarditis, especially concurrent with alcohol intoxication have been shown to be alleviated by intravenous administration of 0.015% sodium hypochlorite solution. In diphtheric polyneuritis it was anticholinesterase agents (neostigmine methylsulfate up to 6 mg daily) in maximum permissible doses that the authors employed in critical cases together with hyperbaric oxygenation and, as a means to improve metabolism,--lecithin and amniocen, a biological stimulant from human placenta.
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D058186:Acute Kidney Injury / Q000188:drug therapy; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications / Q000188:drug therapy; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D004165:Diphtheria / Q000150:complications* / Q000473:pathology / Q000628:therapy*; D004298:Dopamine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008875:Middle Aged; D009205:Myocarditis / Q000188:drug therapy / Q000209:etiology; D009388:Neostigmine / Q000008:administration & dosage / Q000627:therapeutic use; D009443:Neuritis / Q000188:drug therapy / Q000209:etiology; D016877:Oxidants / Q000008:administration & dosage / Q000627:therapeutic use; D010713:Phosphatidylcholines / Q000627:therapeutic use; D012973:Sodium Hypochlorite / Q000008:administration & dosage / Q000627:therapeutic use; D014020:Tissue Extracts / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D002316:Cardiotonic Agents; D002800:Cholinesterase Inhibitors; D016877:Oxidants; D010713:Phosphatidylcholines; D014020:Tissue Extracts; C072622:amniocene; D009388:Neostigmine; D012973:Sodium Hypochlorite; D004298:Dopamine