Dendritic cell vaccines for cancer therapy.
Dendritic cells (DC) are professional antigen-presenting cells whose primary function is the initiation of immune response. Based on the finding that the immune system usually fails to identify and kill cancer cells, DC have been recently used as vaccines for stimulation of tumour-specific immunity. This review focuses on pitfalls related to DC-based vaccination against solid tumours and on improvement of this immunotherapeutic approach for routine treatment of cancer disease.
Sprinzl
G M
GM
Department of Otorhinolaryngology, Head and Neck Surgery, University of Innsbruck, Austria. georg.sprinzl@uibk.ac.at
Kacani
L
L
Schrott-Fischer
A
A
Romani
N
N
Thumfart
W F
WF
D000276:Adjuvants, Immunologic; D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology*; D019496:Cancer Vaccines; D002986:Clinical Trials as Topic; D003713:Dendritic Cells; D006801:Humans; D007111:Immunity, Cellular; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D019496:Cancer Vaccines