Alteration of vasoreactivity of mesenteric arteries in rats after two-week simulated weightlessness.
To investigate the effects of simulated weightlessness on vasoreactivity of mesenteric arteries, rats were tail-suspended for two weeks, and vasoreactivity were studied in vitro using isolated mesenteric arterial ring. The results showed that maximal contractile responses to KCl (10-80 mmol/L) and phenylephrine (PE, 10(-10)-10(-4) mol/L) were attenuated in arterial rings isolated from tail-suspended rats. After constriction caused by 10(-7) mol/L PE, maximal dilatory responses induced by sodium nitroprusside (SNP, 10(-10)-10(-4) mol/L) were not different between tail-suspended and control groups. These data indicated that contractile ability of mesenteric artery was diminished by tail-suspension, whereas the dilatory capacity of arterial smooth muscle was not altered.
Ma
J
J
Department of Aerospace Biodynamics, Fourth Military Medical University, Xi'an, China.
Zhang
L
L
Yang
T
T
D000818:Animals; D019417:Hindlimb Suspension; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014655:Vascular Resistance / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation; D014665:Vasodilator Agents / Q000494:pharmacology; D018474:Weightlessness Simulation
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine; D011189:Potassium Chloride