title: The G-algorithm for extraction of robust decision rules--children's postoperative intra-atrial arrhythmia case study.
abstract: Clinical medicine is facing a challenge of knowledge discovery from the growing volume of data. In this paper, a data mining algorithm (G-algorithm) is proposed for extraction of robust rules that can be used in clinical practice for better understanding and prevention of unwanted medical events. The G-algorithm is applied to the data set obtained for children born with a malformation of the heart (univentricular heart). As the result of the Fontan surgical procedure, designed to palliate the children, 10%-35% of patients postoperatively develop an arrhythmia known as the intra-atrial reentrant tachycardia. There is an obvious need to identify the children that may develop the tachycardia before the surgery is performed. Prior attempts to identify such children with statistical techniques have been unrewarding. The G-algorithm discussed in this paper shows that there exists an unambiguous relationship between measurable features and the tachycardia. The data set used in this study shows that, for 78.08% of infants, the occurrence of tachycardia can be accurately predicted. The authors' prior computational experience with diverse medical data sets indicates that the percentage of accurate predictions may become even higher if data on additional features is collected for a larger data set.
authors.affiliation: Intelligent Systems Laboratory, The University of Iowa, Iowa City 52242-1527, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kusiak
authors.forename: I H
authors.initials: IH
authors.lastname: Law
authors.forename: M
authors.initials: M
authors.lastname: Dick
mesh_terms: D000465:Algorithms; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D002648:Child; D016208:Databases, Factual; D003657:Decision Making; D018729:Fontan Procedure / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D007223:Infant; D011183:Postoperative Complications / Q000209:etiology*; D011379:Prognosis