title: Role of urotensin II in patients on dialysis.
abstract: Urotensin II is a potent vasoconstrictor, which also has some vasodilatory properties. We investigated its expression in various tissues and in the plasma of patients with renal dysfunction. Plasma concentrations of urotensin II-like immunoreactivity were 2-fold higher in patients not on dialysis and 3-fold higher in those on haemodialysis thanin healthy individuals. Messenger RNA encoding theurotensin II precursor and the urotensin II receptor precursor were expressed in various human tissues. The peptidemight act as an important regulator in the cardiovascularand renal systems. Urotensin II antagonists could, therefore, be useful in the treatment of diseases affecting theseorgans.
authors.forename: K
authors.initials: K
authors.lastname: Totsune
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: Z
authors.initials: Z
authors.lastname: Arihara
authors.forename: M
authors.initials: M
authors.lastname: Sone
authors.forename: F
authors.initials: F
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Sasano
authors.forename: O
authors.initials: O
authors.lastname: Murakami
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics; D011863:Radioimmunoassay; D011956:Receptors, Cell Surface / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D006435:Renal Dialysis; D014018:Tissue Distribution; D014579:Urotensins / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C121697:UTS2R protein, human; D014579:Urotensins; C029677:urotensin II