Diverse clinical outcomes of eosinophilic patients with T-cell receptor gene rearrangements: the emerging diagnostic importance of molecular genetics testing.
Abnormal clones of clusters of differentiation (CD)3(-)CD4(+) or CD3(+)CD4(-)CD8(-) phenotypically abnormal lymphocytes have been identified in some patients who have the idiopathic hypereosinophilic syndrome. This report illustrates the disparate clinical courses of six eosinophilic patients with evidence of abnormal T-cell clones based on the finding of a T-cell receptor gene rearrangement. The data suggest that molecular genetics testing for T-cell receptor gene rearrangements should be included in the routine work-up of patients with idiopathic eosinophilia.
Butterfield
J H
JH
Department of Allergy and Outpatient Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002999:Clone Cells / Q000378:metabolism / Q000473:pathology; D004802:Eosinophilia / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D005260:Female; D015321:Gene Rearrangement; D019672:Genes, T-Cell Receptor / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D016896:Treatment Outcome