title: Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients.
abstract: In this (1)H-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.
authors.affiliation: Department of Psychiatry, University of Bonn, Germany. jessen@uni-bonn.de
authors.forename: F
authors.initials: F
authors.lastname: Jessen
authors.forename: W
authors.initials: W
authors.lastname: Block
authors.forename: F
authors.initials: F
authors.lastname: Träber
authors.forename: E
authors.initials: E
authors.lastname: Keller
authors.forename: S
authors.initials: S
authors.lastname: Flacke
authors.forename: R
authors.initials: R
authors.lastname: Lamerichs
authors.forename: H H
authors.initials: HH
authors.lastname: Schild
authors.forename: R
authors.initials: R
authors.lastname: Heun
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism* / Q000523:psychology; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D003072:Cognition Disorders / Q000378:metabolism* / Q000523:psychology; D003401:Creatine / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013702:Temporal Lobe / Q000378:metabolism*
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine