title: Dynamics of chromosomal aberrations in male mice of various strains during aging.
abstract: We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of mutations in their somatic cells and gametes.
authors.affiliation: Department of Biology and Genetics, I. P. Pavlov St. Petersburg State Medical University. biology@spmu.ru
authors.forename: S V
authors.initials: SV
authors.lastname: Rozenfel'd
authors.forename: E F
authors.initials: EF
authors.lastname: Togo
authors.forename: V S
authors.initials: VS
authors.lastname: Mikheev
authors.forename: I G
authors.initials: IG
authors.lastname: Popovich
authors.forename: M A
authors.initials: MA
authors.lastname: Zabezhinskii
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D002869:Chromosome Aberrations; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009154:Mutation; D013045:Species Specificity