title: Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia.
abstract: Copper-62 labeled diacetyl-bis(N4-methylthiosemicarbazone) (62Cu-ATSM) has been proposed as a generator produced positron-emitting tracer for hypoxic tissue imaging. To clarify the usefulness of 62Cu-ATSM for myocardial ischemia, 62Cu-ATSM PET was performed in 7 patients with coronary artery disease. Increased myocardial uptake of 62Cu-ATSM was observed (myocardium/blood ratio: 3.09) in one patient with unstable angina, who had increased 18F-fluorodeoxyglucose (18F-FDG) uptake under the fasting condition. The other 6 patients, who were clinically stable, did not have increased 62Cu-ATSM uptake, although abnormal 18F-FDG uptake was seen in 4 patients. This preliminary study suggests that 62Cu-ATSM is a promising PET tracer for hypoxic imaging in acute ischemia.
authors.affiliation: Department of Radiology, Fukui Medical University, Japan. tsucchy@fmsra.fukui-med.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Fujibayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Yonekura
authors.forename: M J
authors.initials: MJ
authors.lastname: Welch
authors.forename: A
authors.initials: A
authors.lastname: Waki
authors.forename: T
authors.initials: T
authors.lastname: Tsuchida
authors.forename: N
authors.initials: N
authors.lastname: Sadato
authors.forename: K
authors.initials: K
authors.lastname: Sugimoto
authors.forename: A
authors.initials: A
authors.lastname: Nakano
authors.forename: J D
authors.initials: JD
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Itoh
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000000981:diagnostic imaging; D001692:Biological Transport; D056831:Coordination Complexes; D003301:Copper Radioisotopes / Q000493:pharmacokinetics*; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D016166:Free Radical Scavengers / Q000493:pharmacokinetics; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D009206:Myocardium / Q000378:metabolism; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals; D013882:Thiosemicarbazones / Q000493:pharmacokinetics*; D014055:Tomography, Emission-Computed
chemical_list: D056831:Coordination Complexes; D003301:Copper Radioisotopes; D016166:Free Radical Scavengers; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013882:Thiosemicarbazones; C089548:copper (II) diacetyl-di(N(4)-methylthiosemicarbazone); D019788:Fluorodeoxyglucose F18