title: Radiosensitivity parameters for lethal mutagenesis in Caenorhabditis elegans.
abstract: For the first time track structure theory has been applied to radiobiological effects in a living organism.  Data for lethal mutagenesis in Caenorhabditis elegans, obtained after irradiation with nine different types of ions of atomic number 1-57 and gamma rays have yielded radiosensitivity parameters (E0, sigma 0, kappa, m = 68 Gy, 2.5 x 10(-9) cm2, 750, 2) comparable with those found for the transformation of C3HT10 1/2 cells (180 Gy, 1.15 x 10(-10) cm2, 750, 2) but remote from those (E0 and sigma 0 = approximately 2 Gy, approximately 5 x 10(-7) cm2) for mammalian cell survival.
authors.affiliation: NASA Langley Research Center, Hampton, VA 23681-0002.
authors.forename: F A
authors.initials: FA
authors.lastname: Cucinotta
authors.forename: J W
authors.initials: JW
authors.lastname: Wilson
authors.forename: R
authors.initials: R
authors.lastname: Katz
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000528:radiation effects*; D003359:Cosmic Radiation; D005720:Gamma Rays; D017238:Genes, Helminth; D007477:Ions; D008954:Models, Biological; D016296:Mutagenesis; D009154:Mutation; D011853:Radiobiology / Q000379:methods
chemical_list: D007477:Ions