Effects of six antihypertensive drugs on blood pressure and hypothalamic GABA content in spontaneously hypertensive rats.
In order to investigate the effects of antihypertensive drugs on blood pressure and gamma-amino butyric acid (GABA) content in the hypothalamus and the possible relationship between blood pressure decrease and GABA content changes, blood pressure and GABA contents after chronic (20 weeks) treatments of nitrendipine, atenolol, captopril, hydrochlorothiazide, dihydralazine and prazosin were studied in spontaneously-hypertensive rats (SHR). The acute and subacute (1 week) effects of nitrendipine on GABA contents was also observed in SHR. It was found that 20 week treatments with six different antihypertensive agents produced a decrease in systolic blood pressure and an increase in GABA content. The blood pressure level was significantly correlated with GABA content in the hypothalamus, but not with that in the cortex. Acute treatment with a single dose of nitrendipine, did not alter GABA content. Bicuculline, a GABA receptor antagonist, did not attenuate the hypotensive effect of nitrendipine. In conclusion, chronic treatments by different antihypertensive agents produced an increase of hypothalamic GABA content and a decrease of blood pressure. The increase of GABA content induced by nitrendipine seems likely to be secondary to blood pressure decrease.
Guan
Y
Y
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China.
Miao
C Y
CY
Su
D F
DF
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D005260:Female; D018756:GABA Antagonists / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D000959:Antihypertensive Agents; D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline