title: The role of collagen-derived proteolytic fragments in angiogenesis.
abstract: Basement membrane molecules and fragments derived from them are regulators of biological activities such as cell growth, differentiation and migration. This review describes proteolytically derived fragments from the non-collagenous (NC1) domain at the C-terminus of the basement membrane collagens type IV, XV and XVIII, which have been implicated as regulators of angiogenesis. Endostatin is an endogenous collagen XVIII/NC1 derivative, inhibiting endothelial cell proliferation and migration in vitro and tumor-growth in vivo. A homologous NC1 domain fragment of type XV collagen has anti-angiogenic activity as well. Furthermore, NC1 domain fragments of the most abundant basement membrane collagen, type IV collagen, have been shown to inhibit induced vessel growth.
authors.affiliation: Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. alexander_marneros@hms.harvard.edu
authors.forename: A G
authors.initials: AG
authors.lastname: Marneros
authors.forename: B R
authors.initials: BR
authors.lastname: Olsen
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism*; D024141:Collagen Type IV / Q000378:metabolism*; D043170:Collagen Type XVIII; D043169:Endostatins; D006801:Humans; D006868:Hydrolysis; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010446:Peptide Fragments / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000502:physiology
chemical_list: C085811:COL15A1 protein, human; D024141:Collagen Type IV; D043170:Collagen Type XVIII; D043169:Endostatins; D010446:Peptide Fragments; D003094:Collagen