title: Learning disabilities in individuals exposed prenatally to ionizing radiation: the Hiroshima and Nagasaki experiences.
abstract: The brain, undoubtedly the most complex organ in the mammalian body, is the culmination of a long and interrelated sequence of molecular, cellular and tissue events. Brain function hinges on the orderly progression of these, each of which must occur correctly, temporally and spatially. Impingement on any one will give rise to a less developed system of cellular connections, and hence impaired function. Moreover, the neurons of the central nervous system are not self-renewing and thus neuronal loss cannot be repaired through repopulation. Reanalysis of the data on the prenatally exposed survivors of the atomic bombing of Hiroshima and Nagasaki suggests that severe mental retardation occurs primarily, if not exclusively in the period from the 8th through the 15th week following fertilization. Within this window of vulnerability, the increase in mental retardation appears linear with dose and without threshold. More subtle functional effects also occur as reflected in diminished performance on intelligence tests and in school. These findings and their implications for space travel and regulatory agencies charged with the specification of acceptable risks should not require further elaboration in this article given the focus of the radiobiological presentations at this meeting.
authors.affiliation: The Epidemiology Research Center, University of Texas Health Science Center, Houston, TX 77225, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Schull
authors.forename: M
authors.initials: M
authors.lastname: Otake
mesh_terms: D001921:Brain / Q000196:embryology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005314:Embryonic and Fetal Development / Q000528:radiation effects; D005260:Female; D005865:Gestational Age; D006801:Humans; D008607:Intellectual Disability / Q000453:epidemiology* / Q000209:etiology; D007360:Intelligence / Q000528:radiation effects*; D007564:Japan; D007859:Learning Disabilities / Q000453:epidemiology* / Q000209:etiology; D016014:Linear Models; D009689:Nuclear Warfare; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011832:Radiation Injuries / Q000453:epidemiology / Q000209:etiology; D011839:Radiation, Ionizing; D012044:Regression Analysis