Radiation recall reaction following gemcitabine.
A case of dermatitis and myositis in the upper thorax following administration of gemcitabine in a 65-year-old woman with metastatic non small cell lung cancer (NSCLC) is described. The reaction and time course suggest a radiation recall phenomenon. This report joins a small but increasing number of radiation recall events related to gemcitabine. The possibility of a radiation recall reaction should be borne in mind when a patient develops symptoms in a previously irradiated site without evidence of disease progression at that site. Cessation of the precipitating drug is the most important step in management and systemic steroids may hasten symptomatic relief.
Fogarty
G
G
Division of Radiation Oncology, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne Vic., Australia. fogartygerald@petermac.unimelb.edu.au
Ball
D
D
Rischin
D
D
D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy / Q000556:secondary; D003841:Deoxycytidine / Q000009:adverse effects* / Q000031:analogs & derivatives; D004890:Erythema / Q000209:etiology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy; D009220:Myositis / Q000209:etiology*; D011838:Radiation-Sensitizing Agents / Q000009:adverse effects*; D011855:Radiodermatitis / Q000209:etiology*; D000093542:Gemcitabine
D011838:Radiation-Sensitizing Agents; D003841:Deoxycytidine; D000093542:Gemcitabine