title: Understanding metabolic alterations in space flight using quantitative models:  fluid and energy balance.
abstract: This report summarizes many of the results obtained during the Skylab program, on metabolic changes during weightlessness.  The examination of the data was conducted following an integrated multi-disciplinary and multi-experimental approach.  Emphasis is given on several major aspects of metabolic adaptation to space flight:  fluid-electrolyte regulation, mechanisms of hormone disturbances, energy balance and etiology of weight loss.  The aim is to obtain a composite picture of the fluid, electrolyte and energy response to weightlessness.
authors.affiliation: General Electric Company/MATSCO, SW Washington, DC 20024, USA.
authors.forename: J I
authors.initials: JI
authors.lastname: Leonard
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D018495:Fluid Shifts / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D013026:Space Flight; D014882:Water-Electrolyte Balance / Q000502:physiology*; D014893:Weightlessness