title: Stable and unstable chromosomal aberrations among Finnish nuclear power plant workers.
abstract: Twenty nuclear power plant workers with relatively high recorded cumulative doses were studied using FISH chromosome painting and dicentric analysis after solid Giemsa staining. The results indicated that chronic exposure to ionising radiation can be detected on the group level using translocation analysis after chromosome painting, although the mean cumulative dose was approximately 100 mSv. A significant association between translocation frequency and cumulative dose was observed. Variability in the translocation yields among workers with similar recorded doses was large, resulting in a poor correlation between translocation frequencies and documented doses on the individual level. The yields of dicentric and acentric chromosomes were not correlated with the cumulative dose, indicating the inability of unstable aberrations to monitor long-term exposures. It was also shown that the unstable aberrations were not correlated with the most recent annual dose.
authors.affiliation: STUK-Radiation and Nuclear Safety Authority, PO Box 14, FIN-00881 Helsinki, Finland. carita.lindholm@stuk.fi
authors.forename: C
authors.initials: C
authors.lastname: Lindholm
mesh_terms: D000328:Adult; D002503:Centromere; D002869:Chromosome Aberrations; D005387:Finland; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011210:Power Plants; D011829:Radiation Dosage; D012907:Smoking; D014178:Translocation, Genetic / Q000528:radiation effects