title: Potential predictors of asymptomatic ischemic heart disease in patients with vasculogenic erectile dysfunction.
abstract: OBJECTIVE
  To prospectively define the potential predictors of asymptomatic ischemic heart disease in patients with vasculogenic erectile dysfunction using a simple and practical method. Most patients with vasculogenic erectile dysfunction are known to have at least one significant cardiovascular risk factor.
  
  
  METHODS
  After baseline evaluations, patients with erectile dysfunction of presumed vascular origin, who were older than 45 years and with no history of ischemic heart disease, were enrolled in the study. According to the results of repeated pharmacologic erection tests, we divided patients into responders and nonresponders. The cardiologic evaluations consisted of a comprehensive history taking, the assessment of cardiovascular risk factors, a physical examination, and an exercise treadmill test.
  
  
  RESULTS
  A total of 97 patients completed the study. Fifteen (32.6%) of 46 responders and 25 (49.0%) of 51 nonresponders, respectively, had two or more cardiovascular risk factors (P = 0.101). Ischemic ST-segment changes on the exercise treadmill test were only observed in 8 nonresponders (15.7%) (P = 0.006). All these patients were older than 55 years, and seven had two or more cardiovascular risk factors, including hypertension.
  
  
  CONCLUSIONS
  On the basis of these preliminary data, we suggest that cardiovascular evaluations may prove beneficial before prescribing sildenafil to patients with vasculogenic erectile dysfunction who are nonresponders to the pharmacologic erection test, are older than 55 years, and have two or more risk factors, including hypertension.
authors.affiliation: Department of Urology, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Paick
authors.forename: D W
authors.initials: DW
authors.lastname: Park
authors.forename: I
authors.initials: I
authors.lastname: Chae
authors.forename: B
authors.initials: B
authors.lastname: Oh
mesh_terms: D000367:Age Factors; D015897:Comorbidity; D000075202:Contraindications; D004562:Electrocardiography / Q000706:statistics & numerical data; D005080:Exercise Test / Q000706:statistics & numerical data; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology; D018783:Impotence, Vasculogenic / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000453:epidemiology; D010808:Physical Examination; D010879:Piperazines / Q000627:therapeutic use; D011336:Probability; D011687:Purines; D012307:Risk Factors; D012725:Sexual Behavior / Q000502:physiology; D000068677:Sildenafil Citrate; D013450:Sulfones
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate