title: Control of Salmonella enteritidis phage type 4 experimental infection by fosfomycin in newly hatched chicks.
abstract: One hundred and twenty 1-day-old broiler chickens were divided into four groups: group I unmedicated and orally challenged with 1.5 x 10(8) cfu of Salmonella enteritidis phage type 4; group F infected and treated with 300 ppm of fosfomycin in their drinking water; group CF uninfected and treated, and group C maintained as a control group. Their performance, clinical signs, S. enteritidis PT4 reisolation and biochemistry variables were compared. Group F showed fewer symptoms and gross lesions than those from group 1. Fosfomycin treatment at 300 ppm improved body weight at 7 days of age by 42.3%. S. enteritidis PT4 reisolation in group I was higher than in the treated group, but total decontamination of challenged birds was not achieved. There was an increase in the levels of total protein and globulins in group I but not in the treated group. Fosfomycin caused no adverse effects on chickens from group CF, assessed by performance and biochemical variables. The results indicate that fosfomycin could be used in the treatment of S. enteritidis PT4 experimental infection.
authors.affiliation: Department of Animal Pathology, Veterinary Faculty, Zaragoza, Spain. afmedica@posta.unizar.es
authors.forename: A
authors.initials: A
authors.lastname: Fernández
authors.forename: C
authors.initials: C
authors.lastname: Lara
authors.forename: A
authors.initials: A
authors.lastname: Loste
authors.forename: S
authors.initials: S
authors.lastname: Calvo
authors.forename: M C
authors.initials: MC
authors.lastname: Marca
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001434:Bacteriophage Typing / Q000662:veterinary; D001835:Body Weight; D002432:Cecum / Q000382:microbiology; D002645:Chickens; D015169:Colony Count, Microbial / Q000662:veterinary; D005578:Fosfomycin / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000382:microbiology; D011201:Poultry Diseases / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D012481:Salmonella Infections, Animal / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D012483:Salmonella Phages; D012477:Salmonella enteritidis / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity; D013154:Spleen / Q000382:microbiology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin