title: Effect of saponin on mortality and histopathological changes in mice.
abstract: We evaluated the acute toxicity and histopathological effects of saponin (extracted from the plant Citrullus colocynthis) on mice in order to assess its safety. The median lethal dose (LD50) of the saponin was 200 mg/kg. The histological changes were confined to the small intestine, liver and kidney, whereas the stomach, large intestine and heart appeared normal. The changes in the small intestine included haemorrhage and erosion of the mucosa. In addition, hepatorenal damage resulted from necrosis of liver cells and renal tubules.
authors.affiliation: Department of Biology, College of Science, University of Basra, Basra, Iraq.
authors.forename: F H
authors.initials: FH
authors.lastname: Diwan
authors.forename: I A
authors.initials: IA
authors.lastname: Abdel-Hassan
authors.forename: S T
authors.initials: ST
authors.lastname: Mohammed
mesh_terms: D000208:Acute Disease; D000818:Animals; D000855:Anorexia / Q000139:chemically induced / Q000473:pathology; D001763:Blepharoptosis / Q000139:chemically induced / Q000473:pathology; D002423:Cause of Death; D003967:Diarrhea / Q000139:chemically induced / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D005260:Female; D006333:Heart Failure / Q000139:chemically induced / Q000473:pathology; D006470:Hemorrhage / Q000139:chemically induced / Q000473:pathology; D029001:Herbal Medicine; D007003:Hypoglycemia / Q000139:chemically induced / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects / Q000473:pathology; D007493:Iraq; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D009026:Mortality; D009336:Necrosis; D012503:Saponins / Q000633:toxicity*; D012894:Sleep Stages / Q000187:drug effects
chemical_list: D012503:Saponins