A general synthesis of structurally diverse building blocks for preparing analogues of C-linked antifreeze glycoproteins.
A synthetic methodology to afford unusual glycoconjugate building blocks useful for the solid-phase synthesis of C-linked antifreeze glycoprotein (AFGP) analogues is described. Such compounds are urgently required in order to elucidate the molecular mechanism by which AFGPs function. All reactions are general in nature and accommodate structural variation in the carbohydrate moiety, polypeptide backbone, and amino acid side chain.
Eniade
A
A
Department of Chemistry, State University of New York at Binghamton, Binghamton, New York 13902, USA.
Murphy
A V
AV
Landreau
G
G
Ben
R N
RN
D021301:Antifreeze Proteins / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D021301:Antifreeze Proteins