title: Body position and volume status as determinants of cardiovascular responses to transition into microgravity in parabolic flight.
abstract: The condition of microgravity during spaceflight imposes a new challenge to the cardiovascular system and to its homeostatic mechanisms.  Initial fluids shifts from the dependent parts to the upper parts of the body are supposed to induce a plethora of effects which eventually lead to the well-known  puffy faces and chicken legs' of astronauts.  At the same time some 2-3 kgs. in fluid is lost in urine and by diminished uptake.  For research into these longer-term effects of spaceflight extensive physiologic experiments are required in space.  In view of  the high cost and the logistic problems related to space-research much work is done in simulation experiments like bedrest or head down tilt studies.  For the very initial effects of micro-G parabolic flight can be used.  In parabolic flights we have addressed the question of immediate cardiovascular effects of the transition into microgravity.  Since a parabola will last for not more than some 25 seconds, one may expect to observe mainly changes in the outflow of the autonomic nervous system, reflecting in blood pressure and heart rate as easily measurable parameters.  Such changes can be expected to be caused by the sudden disappearance of hydrostatic effects and the shifts of fluid from pools where it is kept under the influence of gravity.  Hydrostatic effects will play a role in the position of the baroreceptors with respect to the heart: in the upright position the carotid sinuses are some 25 cm above heart level, consequently they observe a lower pressure than that at the heart.  When this effect disappears in micro-G a suddenly increased pressure will be observed and the baroreflex is called into action.  On the venous side blood will rush to the right atrium when it is no longer pulled down in the compliant vessels of the abdomen and legs.  This may be expected to lead to increased pressures on the low-pressure side of the heart.  Apart from changes in filling of the left heart this may lead to autonomic nervous effects on systemic blood pressure and heart rate as well.
authors.affiliation: Department of Physiology, Univ. of Amsterdam, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Karemaker
authors.forename: W J
authors.initials: WJ
authors.lastname: Stok
authors.forename: R D
authors.initials: RD
authors.lastname: Latham
mesh_terms: D000328:Adult; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure; D005260:Female; D018495:Fluid Shifts / Q000502:physiology*; D018475:Head-Down Tilt / Q000009:adverse effects*; D006339:Heart Rate; D006801:Humans; D008297:Male; D011187:Posture; D011311:Pressoreceptors / Q000502:physiology*; D013026:Space Flight; D013318:Stroke Volume; D014893:Weightlessness