title: [Relation between mexidol glucuronide conjugation and characteristics of its therapeutic effect in patients with organic lesions in the central nervous system].
abstract: The clinico-pharmacological and pharmacokinetic investigation of mexidole administered in patients with organic CNS damage showed for the first time that there is a correlation between intensity of the drug--glucurone conjugation and the parameters of psychopathological symptom expression and the individual patient state estimation before treatment and upon a single administration or a course of mexidole therapy. This correlation allows the clinico-pharmacological effects and the therapeutic efficacy of mexidole to be predicted based on the drug metabolism index.
authors.affiliation: Laboratory of Pharmacokinetics, Laboratory of Clinical Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
authors.forename: A K
authors.initials: AK
authors.lastname: Sariev
authors.forename: I A
authors.initials: IA
authors.lastname: Davydova
authors.forename: G G
authors.initials: GG
authors.lastname: Neznamov
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: E S
authors.initials: ES
authors.lastname: Teleshova
mesh_terms: D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D005260:Female; D020719:Glucuronides / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010847:Picolines / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D020719:Glucuronides; D010847:Picolines; D011619:Psychotropic Drugs; C070020:emoxypine succinate