Does sperm morphology play a significant role in increased sex chromosomal disomy? A comparison between patients with teratozoospermia and OAT by FISH.
Eight semen samples from men with teratozoospermia (T), along with samples from 3 men with normal fertility and 5 samples from men with oligoasthenoteratozoospermia (OAT) were analyzed for X and Y chromosomal anomalies with the use of fluorescently labeled centromeric probes. This study was undertaken to determine whether patients with abnormal sperm morphology (teratozoospermia) have increased or decreased incidence of a sex chromosomal anomaly. The sex chromosome disomy for the T samples was 0.36% and for the OAT group it was 0.61%, compared with baseline value for the normozoospermia group (0.09%).
Gole
L A
LA
Department of Obstetrics and Gynecology, National University Hospital, Singapore.
Wong
P F
PF
Ng
P L
PL
Wang
X Q
XQ
Ng
S C
SC
Bongso
A
A
D000328:Adult; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D013094:Spermatozoa / Q000166:cytology*