title: Evaluation of the hepatitis B antenatal screening and neonatal immunization program in Amsterdam, 1993-1998.
abstract: In the enhanced antenatal hepatitis B screening and neonatal immunization program in Amsterdam, 691 hepatitis B surface antigen (HBsAg) positive expectant mothers were reported in the period 1993-1998. The coverage of the screening was calculated at 97%. HBsAg-prevalence was high in women from Ghana and South-East Asia, and lowest in Dutch women. Hepatitis B immune globulin (HBIg) was administered within 24h to 95.9% of the neonates; 99.7% completed the vaccination series. About 6 weeks after the third vaccination the titer antiHBs was > or =100 IU/l in 85% of children; in 12% the titers were 10-100 IU/l; 3% had titers <10 IU/l, of whom 3/521 initially had HBsAg. Low birth weight (OR 3.77), being a boy (OR 1.64) and country of origin were predictors of low postvaccination titers. Coordinated by 0.5 full time equivalent (fte) additional staff, the program was relatively cheap and successful.
authors.affiliation: Cluster Infectious Diseases, Municipal Health Service Amsterdam, GG & GD, P.O. Box 2220, 1000 CE, Amsterdam, The Netherlands.
authors.forename: J E
authors.initials: JE
authors.lastname: van Steenbergen
authors.forename: A
authors.initials: A
authors.lastname: Leentvaar-Kuijpers
authors.forename: D
authors.initials: D
authors.lastname: Baayen
authors.forename: H T
authors.initials: HT
authors.lastname: Dukers
authors.forename: G J
authors.initials: GJ
authors.lastname: van Doornum
authors.forename: J A
authors.initials: JA
authors.lastname: van den Hoek
authors.forename: R A
authors.initials: RA
authors.lastname: Coutinho
mesh_terms: D000328:Adult; D005006:Ethnicity; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D017589:Immunization Programs; D007115:Immunization Schedule; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008403:Mass Screening; D008427:Maternal Health Services / Q000458:organization & administration / Q000706:statistics & numerical data; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D011295:Prenatal Care; D015995:Prevalence; D015397:Program Evaluation
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines