title: Circulatory filling pressures during transient microgravity induced by parabolic flight.
abstract: Theoretical concepts hold that blood in the gravity-dependent portion of the body would relocate to more cephalad compartments under microgravity conditions.  The result is an increase in blood volume in the thoracic and cardiac chambers.  This increase in central volume shift should result in an increase in central atrial filling pressures.  However, experimental data has been somewhat contradictory and nonconclusive to date.  Early investigations of peripheral venous pressure and estimates of central venous pressure (CVP) from these data did not show an increase in CVP in the microgravity condition.  However, CVP recorded in human volunteers during the parabolic flight by Norsk revealed an increase in CVP during the microgravity state.  On the June 1991 STS 40 shuttle mission, a payload specialist wore a fluid line that recorded CVP during the first few hours of orbital insertion.  These data revealed decreased CVP.  When this CVP catheter was tested during parabolic flight in four subjects, two subjects had increased CVP recordings and two other subjects had decreased CVP measurements.  In April 1991, our laboratory performed parabolic flight studies in several chronic-instrumented baboon subjects.  It was again noted that centrally recorded right atrial pressure varied with exposure to microgravity, some animals having an increase and others having a decrease.  Thus, data presently available has demonstrated a variable response in the mechanism not clearly defined.  In April 1992, we determined a test hypothesis relating the possible mechanism of these variable pressure responses to venous pressure-volume relationships.
authors.affiliation: Laboratory for Aerospace Cardiovascular Research (LACR), Brooks AFB, Texas 78235-5301.
authors.forename: R D
authors.initials: RD
authors.lastname: Latham
authors.forename: J W
authors.initials: JW
authors.lastname: Fanton
authors.forename: C D
authors.initials: CD
authors.lastname: White
authors.forename: M N
authors.initials: MN
authors.lastname: Vernalis
authors.forename: R P
authors.initials: RP
authors.lastname: Crisman
authors.forename: S C
authors.initials: SC
authors.lastname: Koenig
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D002496:Central Venous Pressure / Q000502:physiology*; D018471:Hypergravity; D008297:Male; D010215:Papio; D011187:Posture / Q000502:physiology; D013026:Space Flight; D014893:Weightlessness