title: Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age.
abstract: The National Marrow Donor Program (NMDP) maintains a registry of approximately 4 million volunteer unrelated donors for patients in need of a stem cell transplant. When several comparably HLA-matched volunteers are identified for a patient, various criteria are used to select a donor. A retrospective analysis of 6978 bone marrow transplantations facilitated by the NMDP from 1987 to 1999 was conducted to study the effects of various donor characteristics on recipient outcome. The evaluation addressed possible effects of donor age, cytomegalovirus serologic status, ABO compatibility, race, sex, and parity on overall and disease-free survival, acute and chronic graft-versus-host disease (GVHD), engraftment, and relapse. Age was the only donor trait significantly associated with overall and disease-free survival. Five-year overall survival rates for recipients were 33%, 29%, and 25%, respectively, with donors aged 18 to 30 years, 31 to 45 years, and more than 45 years (P =.0002). A similar effect was observed among HLA-mismatched cases (28%, 22%, and 19%, respectively). A race mismatch between recipient and donor did not affect outcome. The cumulative incidences of grade III or IV acute GVHD were 30%, 34%, and 34%, respectively, with donors aged 18 to 30 years, 31 to 45 years, and more than 45 years (P =.005). The corresponding incidences of chronic GVHD at 2 years were 44%, 48%, and 49% (P = 0.02). Recipients with female donors who had undergone multiple pregnancies had a higher rate of chronic GVHD than recipients with male donors (54% versus 44%; P <.0001). The use of younger donors may lower the incidence of GVHD and improve survival after bone marrow transplantation. Age should be considered when selecting among comparably HLA-matched volunteer donors.
authors.affiliation: National Marrow Donor Program, Research Department, Minneapolis, MN 55413, USA. ckollman@nmdp.org
authors.forename: C
authors.initials: C
authors.lastname: Kollman
authors.forename: C W
authors.initials: CW
authors.lastname: Howe
authors.forename: C
authors.initials: C
authors.lastname: Anasetti
authors.forename: J H
authors.initials: JH
authors.lastname: Antin
authors.forename: S M
authors.initials: SM
authors.lastname: Davies
authors.forename: A H
authors.initials: AH
authors.lastname: Filipovich
authors.forename: J
authors.initials: J
authors.lastname: Hegland
authors.forename: N
authors.initials: N
authors.lastname: Kamani
authors.forename: N A
authors.initials: NA
authors.lastname: Kernan
authors.forename: R
authors.initials: R
authors.lastname: King
authors.forename: V
authors.initials: V
authors.lastname: Ratanatharathorn
authors.forename: D
authors.initials: D
authors.lastname: Weisdorf
authors.forename: D L
authors.initials: DL
authors.lastname: Confer
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000592:standards; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology; D006648:Histocompatibility; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D044469:Racial Groups; D012008:Recurrence; D012042:Registries; D012307:Risk Factors; D015996:Survival Rate; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000592:standards