[Selective-occlusive method of drug administration in the treatment of experimental liver tumors].
263 experimental studies on 184 rats were carried out. Hepatic tumors were provoked by intraparenchymatous implantation of 0.1 ml 20% tumoral suspension of mucous cancer (RS-I). Treatment was realized on 10-12 day after vaccination. Photodynamic therapy with "Photosense" (PS) and laser irradiation (670 nm, 50-100 Dj, 4-13 mm), and also catalytic therapy (CT) with "Teraftal" (TF) and ascorbic acid (AA) were used. FS and TF were administered by developed selective-occilisive method (SOM). Rapid accumulation of drugs in occluded lobe of liver was revealed in SOM, that permitted to decrease administered dose of TF in 16.5 times. There was no growth of tumor after FDT unlike control group. Same results were obtained after CT with SOM, but there was further growth of tumor after systemic administration of drugs. Developed SOM of drugs administration in FDT and CT lead to good results in treatment of experimental hepatic tumors.
Gal'perin
E I
EI
Diuzheva
T G
TG
Nakhamiiaev
V R
VR
Goloshchapov
R S
RS
Bochkarev
V P
VP
Mogirev
S V
SV
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage; D002384:Catalysis; D007211:Indoles / Q000008:administration & dosage; D007834:Lasers; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage; D010778:Photochemotherapy; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
D000970:Antineoplastic Agents; D000975:Antioxidants; D007211:Indoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C403768:theraphthal; C048577:aluminum tetrasulfophthalocyanine; D001205:Ascorbic Acid