Commentary: Immune escape versus tumor tolerance: how do tumors evade immune surveillance?
Despite an increasing understanding of immunological mechanisms it is still not clear how tumors evade immune-surveillance of the host and how tumors interact with the immune-system. In particular, the question whether tumors arise because of an insufficient immune response or whether tumor cells employ active strategies to escape the control of the immune system is still open. Data from a great number of in vitro studies and animal models offer arguments for both the theory of an immune escape as well as that of tumor tolerance. In this article the available results regarding the mechanisms of host-tumor-interaction are discussed with focus on these two contrary hypotheses.
Salih
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Medizinische Klinik II, Eberhard Karls Universität, Tübingen, Germany.
Nüssler
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D000375:Aging / Q000276:immunology; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D017209:Apoptosis; D016207:Cytokines / Q000502:physiology; D004198:Disease Susceptibility; D000939:Epitopes / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D016867:Immunocompromised Host; D007157:Immunologic Surveillance; D008213:Lymphocyte Activation; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D018448:Models, Immunological; D018716:Molecular Mimicry; D009369:Neoplasms / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000951:Antigens, Neoplasm; D016207:Cytokines; D000939:Epitopes; D006680:HLA Antigens; D011971:Receptors, Immunologic