Role of adenosine receptors in neuroprotective effect during global cerebral ischemia.
Selective A(1)adenosine receptor agonists produced a considerable neuroprotective effect during global cerebral ischemia. The neuroprotective effect decreased in the order: A(1)agonists-NECA-adenosine-A(2A)agonist CGS 21680, while selective A(3)adenosine receptor agonist was ineffective. Inhibitory analysis showed that A(1)adenosine receptors mediate the neuroprotective effect of CPA, are involved in the effects of NECA and adenosine (but not CGS 21680), and participate in natural resistance to cerebral ischemia. The role of A(2B)adenosine receptors in the realization of neuroprotective effects was also demonstrated.
Kulinsky
V I
VI
Department of Biochemistry, Department of Pharmacology, Irkutsk Medical University. kulinsky@pp.irkutsk.ru
Minakina
L N
LN
Usov
L A
LA
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D002545:Brain Ischemia / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007511:Ischemia; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects*; D010627:Phenethylamines / Q000494:pharmacology; D018047:Receptors, Purinergic P1 / Q000502:physiology*
D000959:Antihypertensive Agents; D010627:Phenethylamines; D018047:Receptors, Purinergic P1; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; D000241:Adenosine