Chemical protection against ionizing radiation.
Some of the problems related to chemical protection against ionizing radiation are discussed with emphasis on: definition, classification, degree of protection, mechanisms of action and toxicity. Results on the biological response modifyers (BRMs) and on the combination of nontoxic (i.e. low) doses of sulphydryl radioprotectors and BRMs are presented.
Maisin
J R
JR
Unite de Radiotherapie et de Radioprotection, UCL-Faculte de Medecine, Bruxelles, Belgium.
D004999:Amifostine / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D003545:Cysteine / Q000627:therapeutic use / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000627:therapeutic use / Q000633:toxicity; D007155:Immunologic Factors / Q000627:therapeutic use*; D051379:Mice; D011134:Polysaccharides / Q000627:therapeutic use* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000517:prevention & control*; D011839:Radiation, Ionizing; D011837:Radiation-Protective Agents / Q000145:classification / Q000627:therapeutic use* / Q000633:toxicity; D012701:Serotonin / Q000627:therapeutic use / Q000633:toxicity; D013438:Sulfhydryl Compounds / Q000627:therapeutic use* / Q000633:toxicity
D007155:Immunologic Factors; D011134:Polysaccharides; D011837:Radiation-Protective Agents; D013438:Sulfhydryl Compounds; D012701:Serotonin; D005978:Glutathione; D003545:Cysteine; D004999:Amifostine