title: [Immunoprophylaxis of acute respiratory diseases with bacterial multicomponent vaccine VP-4 in children at preschool institutions].
abstract: The prophylactic action of polycomponent vaccine B[symbol: see text]-4, prepared from the antigens of opportunistic bacteria, on morbidity rate in acute respiratory diseases (ARD) of bacterial and mixed (bacterial and viral) etiology in 121 children aged 2-5 years, attending pre-school institutions was evaluated. For comparison, a group of 118 children of the same age from the same institutions was formed. The vaccine was introduced after the schedule consisting of 3 intranasal and 6-9 oral administrations made at intervals of 3-4 days. The duration of the course of immunization was 26 +/- 4 days. The prophylactic effect of B[symbol: see text]-4 on ARD morbidity was evaluated by the number of ARD cases and their duration per child. The prophylactic effect of B[symbol: see text]-4 on ARD morbidity lasted 14 months (the term of observation) after immunization and was manifested by a decrease in the number and duration of ARD cases after administration of the preparation, also in a group of highly susceptible children.
authors.affiliation: Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
authors.forename: N B
authors.initials: NB
authors.lastname: Egorova
authors.forename: B F
authors.initials: BF
authors.lastname: Semenov
authors.forename: E A
authors.initials: EA
authors.lastname: Kurbatova
authors.forename: V N
authors.initials: VN
authors.lastname: Efremova
authors.forename: I M
authors.initials: IM
authors.lastname: Gruber
authors.forename: L A
authors.initials: LA
authors.lastname: Kuz'mina
authors.forename: I B
authors.initials: IB
authors.lastname: Semenova
authors.forename: I N
authors.initials: IN
authors.lastname: Lytkina
authors.forename: S V
authors.initials: SV
authors.lastname: Serzhenko
authors.forename: O P
authors.initials: OP
authors.lastname: Samarina
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Slepoĭ
authors.forename: N V
authors.initials: NV
authors.lastname: Egorova
mesh_terms: D000208:Acute Disease; D001428:Bacterial Vaccines; D002648:Child; D002675:Child, Preschool; D006801:Humans; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control* / Q000821:virology; D017778:Vaccines, Combined
chemical_list: D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined