Chemical synoviorthesis with osmic acid in haemophilia.
Based on previous experience in inflammatory arthritis, a small number of open studies have evaluated the usefulness of chemical synoviorthesis with osmic acid in haemophilia, with various assessment criteria and a wide range of follow-up periods. Based on these studies, the efficacy of osmic acid seems modest, with 30-44% of good clinical and radiological results, but with fair or poor clinical results in other patients with a possible deleterious effect on cartilage. Osmic acid was found inferior to Yttrium-90 in one retrospective study. Synoviorthesis with osmic acid seems particularly indicated in haemophilic arthritis with no or mild radiological deterioration in children between 8 and 15 years of age. However, prospective randomized studies are clearly required to evaluate the symptomatic and structural effects of chemical and radioactive synoviorthesis in haemophilic arthritis.
Ayral
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Service de Rhumatologie B, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université René Descartes, Paris, France. xavier.ayra@cch.ap-hop-paris.fr
D000367:Age Factors; D006395:Hemarthrosis / Q000150:complications / Q000188:drug therapy / Q000209:etiology; D006467:Hemophilia A / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006801:Humans; D009993:Osmium Tetroxide / Q000627:therapeutic use*; D011868:Radioisotopes / Q000627:therapeutic use; D013585:Synovitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D011868:Radioisotopes; D009993:Osmium Tetroxide