Microarrays in primary breast cancer--lessons from chemotherapy studies.
Current development in molecular techniques has extended the opportunities to explore genetic alterations in malignant tissue. There is a need to improve prognostication and, in particular, to understand the mechanisms of treatment resistance in different tumours. Gene analyses by microarrays allow concomitant analyses of several genes in concert, providing new opportunities for tumour classification and understanding of key biological disturbances. This paper outlines our continuing studies exploring prognostic and, we hope, predictive factors in breast cancer therapy.
Lønning
P E
PE
Section of Oncology, Department of Medicine, Haukeland University Hospital, Bergen, Norway. plon@haukeland.no
Sørlie
T
T
Perou
C M
CM
Brown
P O
PO
Botstein
D
D
Børresen-Dale
A L
AL
D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D004847:Epithelial Cells / Q000502:physiology; D005260:Female; D005456:Fluorescent Dyes; D020869:Gene Expression Profiling; D018734:Genes, erbB-2 / Q000502:physiology*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D015203:Reproducibility of Results; D014407:Tumor Cells, Cultured
D005456:Fluorescent Dyes; D012334:RNA, Neoplasm