title: Subpicosecond conformational dynamics of small peptides probed by two-dimensional vibrational spectroscopy.
abstract: The observation of subpicosecond fluctuations in the conformation of a small peptide in water is demonstrated. We use an experimental method that is specifically sensitive to conformational dynamics taking place on an ultrafast time scale. Complementary molecular-dynamics simulations confirm that the conformational fluctuations exhibit a subpicosecond component, the time scale and amplitude of which agree well with those derived from the experiment.
authors.affiliation: Max-Born-Institute for Nonlinear Optics and Short Pulse Spectroscopy, Max-Born-Strasse 2A, D-12489 Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Woutersen
authors.forename: Y
authors.initials: Y
authors.lastname: Mu
authors.forename: G
authors.initials: G
authors.lastname: Stock
authors.forename: P
authors.initials: P
authors.lastname: Hamm
mesh_terms: D003198:Computer Simulation; D003903:Deuterium; D007700:Kinetics; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation; D013055:Spectrophotometry, Infrared / Q000379:methods; D013997:Time Factors; D014732:Vibration
chemical_list: D009842:Oligopeptides; C039944:alanyl-alanyl-alanine; D003903:Deuterium