The role of hydration and radiation quality in the induction of DNA damage--chemical aspects.
The mutagenic and lethal effects of ionising radiation are thought to result from chemical modifications induced within DNA. This DNA damage is significantly influenced by the chemical environment and the radiation quality (LET). Water closely associated with the DNA and its immediate environment is involved in the early chemical pathways which lead to the induction of DNA damage and is reflected in the cellular radiosensitivity. For instance, hydration of DNA influences hole migration leading to its localisation at guanine. Changes in the radiation quality are discussed in terms of the complexity of the radical clusters produced. It is inferred that at higher LET, the influence of the chemical environment (O2 etc) decreases with respect to DNA damage and cellular radiosensitivity. It is therefore important to include these effects of environment of the DNA upon the early chemical pathways in models of radiation action.
O'Neill
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Division of Radiobiological Mechanisms, MRC Radiobiology Unit, Didcot, U.K.
D004247:DNA / Q000737:chemistry* / Q000187:drug effects / Q000528:radiation effects*; D004249:DNA Damage; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004583:Electrons; D017665:Hydroxyl Radical; D018499:Linear Energy Transfer; D049449:Luminescence; D010100:Oxygen; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D012062:Relative Biological Effectiveness; D014867:Water / Q000737:chemistry*
D014867:Water; D017665:Hydroxyl Radical; D004247:DNA; D010100:Oxygen; D004121:Dimethyl Sulfoxide