Hypergravity signal transduction and gene expression in cultured mammalian cells.
A number of studies have been conducted during space flight and with clinostats and centrifuges, suggesting that gravity effects the proliferation and differentiation of mammalian cells in vitro.  However, little is known about the mechanisms by which mammalian cells respond to changes in gravitational stress.  This paper summarizes studies designed to clarify the effects of hypergravity on the cultured human HeLa cells and to investigate the mechanism of hypergravity signal transduction in these cells.
Kumei
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Biomedical Operations and Research Branch, NASA/Johnson Space Center, Houston, TX 77058, USA.
Whitson
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PA
D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002498:Centrifugation; D000242:Cyclic AMP / Q000378:metabolism; D015870:Gene Expression / Q000502:physiology*; D016259:Genes, myc / Q000235:genetics; D006367:HeLa Cells / Q000166:cytology* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D018471:Hypergravity; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*; D013936:Thymidine / Q000493:pharmacokinetics; D014407:Tumor Cells, Cultured
D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP; D013936:Thymidine