title: Fungicidal activity of beta-thujaplicin analogues.
abstract: The fungicidal activity of analogues of beta-thujaplicin, a natural product responsible for the durability of heartwood of several cupressaceous trees, was investigated in vitro on the growth of different white and brown rot fungi involved in wood biodegradation, Coriolus versicolor, Phanerochaete chrysosporium, Poria placenta and Gloephyllum trabeum. The study shows that 2-hydroxycyclohepta-2,4,6-trienone (tropolone), easily prepared according to a literature procedure, possesses interesting fungicidal activity when compared to beta-thujaplicin, azaconazole, tebuconazole and copper oxine, which suggests this compound should be examined further as a potential biocide for wood preservation.
authors.affiliation: Laboratoire d'Etudes et de Recherches sur le Matériau Bois, UMR INRA 1093, Equipe de Chimie Organique et Microbiologie, Université Henri Poincaré, Nancy I, Faculté des Sciences, BP 239, 54506 Vandoeuvre-lès-Nancy, France.
authors.forename: M
authors.initials: M
authors.lastname: Baya
authors.forename: P
authors.initials: P
authors.lastname: Soulounganga
authors.forename: E
authors.initials: E
authors.lastname: Gelhaye
authors.forename: P
authors.initials: P
authors.lastname: Gérardin
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001487:Basidiomycota / Q000187:drug effects* / Q000254:growth & development; D001673:Biodegradation, Environmental; D004305:Dose-Response Relationship, Drug; D005659:Fungicides, Industrial / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D039821:Monoterpenes; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development; D014334:Tropolone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D014934:Wood
chemical_list: D000890:Anti-Infective Agents; D005659:Fungicides, Industrial; D039821:Monoterpenes; D014334:Tropolone; C009479:beta-thujaplicin