title: Mechanisms of vascular adaptation to long-term orthostatic gravitational loading.
abstract: Frequent symptoms and serious complaints related to orthostatic intolerance are among the important reasons for investigating the long-term control mechanisms of blood vessels especially those of veins. Previously we studied perfused and superfused saphenous vein segments from rats maintained in head-up tilt position for two weeks. It was found that passive lumen capacity and acute pressure induced myogenic response of these vessels increased substantially without measurable change in wall thickness. Sympathetic component of the smooth muscle cell membrane potential determined in vivo was also significantly enhanced in this vein, but no such change was seen in the saphenous artery and in the brachial vessels. In a separate study, rarefaction of microvessels was found in the hind limb oxydative muscles after two-week tilting, while muscular water content was unaltered. These results suggest that long-term gravitational loading may induce adaptive rearrangement of the blood vessel functions. The aim of the present study was to quantitate and compare the density of nerve fiber terminals as well as their synaptic vesicle population in the wall of saphenous vein and artery from tilted rats to those obtained from rats which were maintained in horizontal, control position. It was hypothetized that adaptation of blood vessels to long-term gravitational loading might include also a morphological restructuring of the vascular adrenergic innervation.
authors.affiliation: Clinical Research Department, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Monos
authors.forename: M
authors.initials: M
authors.lastname: Lorant
authors.forename: E
authors.initials: E
authors.lastname: Feher
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001158:Arteries / Q000033:anatomy & histology / Q000294:innervation / Q000502:physiology* / Q000648:ultrastructure; D001794:Blood Pressure; D006799:Housing, Animal; D007024:Hypotension, Orthostatic / Q000503:physiopathology; D008854:Microscopy, Electron; D011187:Posture / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012501:Saphenous Vein / Q000033:anatomy & histology / Q000294:innervation / Q000502:physiology* / Q000648:ultrastructure; D013572:Synaptic Vesicles / Q000502:physiology*