Analyzing single protein molecules using optical methods.
Studies on single protein molecules have advanced from mere proofs of principle to insightful investigations of otherwise inaccessible biological phenomena. Recent studies predict a tremendous number of possible future applications. The long-term vision of biologists to watch single molecular processes in real time by peering into a cell with three-dimensional resolution might finally be realized. Another fascinating perspective is the identification and selection of single favorable variants from complex libraries of diverse biomolecules.
Schwille
P
P
Experimental Biophysics Group, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany. pschwil@gwdg.de
Kettling
U
U
D004058:Diffusion; D005456:Fluorescent Dyes / Q000032:analysis; D018625:Microscopy, Atomic Force / Q000295:instrumentation; D018613:Microscopy, Confocal / Q000295:instrumentation; D008856:Microscopy, Fluorescence / Q000295:instrumentation; D055095:Optics and Photonics; D011506:Proteins / Q000032:analysis*
D005456:Fluorescent Dyes; D011506:Proteins