Genetic polymorphisms in the androgen receptor and type II 5 alpha-reductase genes in prostate enlargement.
OBJECTIVE
We examined the association of androgen receptor gene cytosine-adenine-guanine (CAG) repeat length and the 2 single nucleotide polymorphisms A49T and V89L in the type II 5 alpha-reductase gene with prostate enlargement measured as the weight of the surgically removed prostate.


METHODS
A total of 68 men with a prostate weighing 80 gm. or greater were compared with 197 controls with a prostate weighing less than 80 gm. These men had undergone radical prostatectomy between 1992 and 1996. DNA was extracted from archival prostate tissue uninvolved with cancer and genotyped for 3 polymorphic markers. The effects of genetic variants and clinicopathological variables on prostate enlargement risk were estimated by logistic regression.


RESULTS
The age adjusted odds ratio estimate of prostate enlargement risk in men with 23 or greater versus 20 or fewer CAG repeats was 0.41 (95% confidence interval 0.19 to 0.89). This risk reduction was consistently found when an alternative prostate enlargement definition and subject restriction were used. No consistent association with prostate enlargement risk was observed for A49T or V89L polymorphisms.


CONCLUSIONS
Our finding further supports the hypothesis that the shorter CAG repeat length of the androgen receptor gene is related to prostate enlargement.
Shibata
A
A
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA.
Stamey
T A
TA
McNeal
J E
JE
Cheng
I
I
Peehl
D M
DM
D000225:Adenine; D000368:Aged; D042944:Cholestenone 5 alpha-Reductase; D003596:Cytosine; D006147:Guanine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010088:Oxidoreductases / Q000235:genetics*; D011110:Polymorphism, Genetic; D011470:Prostatic Hyperplasia / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics*; D018911:Trinucleotide Repeats / Q000235:genetics
D011944:Receptors, Androgen; D006147:Guanine; D003596:Cytosine; D010088:Oxidoreductases; D042944:Cholestenone 5 alpha-Reductase; D000225:Adenine