[Markers of retinal-type cell differentiation in studies of eye development and regeneration in vertebrates].
Data on the use of various immunochemical markers specifically indicating cell types of the neural retina and pigment epithelium are reviewed. It is demonstrated how this approach can be applied to the analysis of specific features of vertebrate retinal development, including the order and timing of differentiation of the main cell types, their interdependence in the course of this process, and factors controlling the latter. Problems concerning the state of differentiation and its change in the cells of retinal pigment epithelium and glial cells are discussed in respect to their analysis with the aid of specific protein markers. The current state of retina regeneration research involving the use of labelled cell sources and regenerated cells in lower vertebrates is analyzed. Problems in the search for new markers of retinal photoreceptor, macroglial, and microglial cells and their use in experiments are addressed.
Grigorian
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Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991 GSP-1, Russia.
D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation; D005123:Eye / Q000196:embryology*; D012038:Regeneration; D012160:Retina / Q000166:cytology*; D014714:Vertebrates / Q000196:embryology*
D015415:Biomarkers