Genetic variations in five genes involved in the excitement of cardiomyocytes.
We provide here 29 genetic variations, including 28 novel ones, in five genes that are potentially involved in the excitement of cardiomyocytes: we found 4 in KCNA10, 2 in KCNK1, 8 in KCNK6, 11 in SLC18A1 (VMAT1), and 4 in SLC6A2 (norepinephrine transporter). We also examined their allelic frequencies in a Japanese population of long QT syndrome-affected and nonaffected individuals. These data would be useful for genetic association studies designed to investigate acquired arrhythmias.
Iwasa
H
H
Human Genome Center, Institute of Medical Science, University of Tokyo, Japan.
Kurabayashi
M
M
Nagai
R
R
Nakamura
Y
Y
Tanaka
T
T
D019943:Amino Acid Substitution; D001483:Base Sequence; D017931:DNA Primers; D014644:Genetic Variation; D006321:Heart / Q000502:physiology*; D006801:Humans; D007438:Introns; D008133:Long QT Syndrome / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics; D026901:Membrane Transport Proteins; D009154:Mutation; D009206:Myocardium / Q000166:cytology; D009479:Neuropeptides; D050484:Norepinephrine Plasma Membrane Transport Proteins; D016133:Polymerase Chain Reaction; D015221:Potassium Channels / Q000235:genetics*; D024683:Potassium Channels, Tandem Pore Domain; D027981:Symporters / Q000235:genetics; D050492:Vesicular Biogenic Amine Transport Proteins; D050493:Vesicular Monoamine Transport Proteins
D017931:DNA Primers; C109137:KCNK1 protein, human; C118290:KCNK6 protein, human; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009479:Neuropeptides; D050484:Norepinephrine Plasma Membrane Transport Proteins; D015221:Potassium Channels; D024683:Potassium Channels, Tandem Pore Domain; C493449:SLC18A1 protein, human; C493227:SLC6A2 protein, human; D027981:Symporters; D050492:Vesicular Biogenic Amine Transport Proteins; D050493:Vesicular Monoamine Transport Proteins