Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.
Capsanthin and related carotenoids isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester and capsorbin diester showed strong inhibitory effects. Furthermore, capsanthin , capsanthin 3'-ester and capsanthin 3,3'-diester , major carotenoids in paprika, exhibited potent anti-tumor-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter.
Maoka
T
T
Research Institute for Production Development, 15 Shimogamo-Morimoto-cho, Sakyo-ku, 606-0805, Kyoto, Japan. maoka@mbox.kyoto-inet.or.jp
Mochida
K
K
Kozuka
M
M
Ito
Y
Y
Fujiwara
Y
Y
Hashimoto
K
K
Enjo
F
F
Ogata
M
M
Nobukuni
Y
Y
Tokuda
H
H
Nishino
H
H
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects; D002212:Capsicum / Q000737:chemistry*; D002338:Carotenoids / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D024341:Xanthophylls
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D024341:Xanthophylls; D002338:Carotenoids; C006889:capsanthin