title: Potential vascular damage from radiation in the space environment.
abstract: Cultured endothelial cells of blood vessels have a Do of 2 Gy for X-rays. A dose of 0.5 Gy of X-rays has an acute effect on vessel diameter. The vessels may show other acute effects such as change in permeability including a change in the blood brain barrier. Changes occurring from late effects of chronic exposure in vascular architecture include telangiectasia and decrease in vascular density. Changes in the perivascular connective tissue particularly collagen may play a role in these changes. After charged particle exposure of 15 and 30 Gy, radiation changes in the blood brain barrier and vascular changes are noted in the nervous system. These long term changes are recorded by PET, MRI, and CT imaging. Chronic exposure to alpha particles causes vascular damage in compact bone resulting in bone infarcts. Using tandem scanning confocal microscopy in-situ imaging of the capillaries and collagen of the papillary dermis provides a non-invasive method of serial recording of changes in irradiated microvasculature.
authors.affiliation: Department of Radiation Oncology, University of Chicago Medical Center, IL 60637, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Griem
authors.forename: A
authors.initials: A
authors.lastname: Robotewskyj
authors.forename: R H
authors.initials: RH
authors.lastname: Nagel
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000528:radiation effects*; D003094:Collagen / Q000378:metabolism / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004423:Ear / Q000098:blood supply / Q000528:radiation effects*; D004817:Epidermis / Q000528:radiation effects*; D006801:Humans; D018613:Microscopy, Confocal / Q000379:methods; D011817:Rabbits; D014741:Video Recording
chemical_list: D003094:Collagen