History of testicular cancer chemotherapy: maximizing efficacy, minimizing toxicity.
All patients presenting with metastatic testis cancer should be treated with the goal of cure. However, all physicians treating patients with germ cell tumors need to be aware of the toxicities of chemotherapy. Because many patients are cured of their disease, both short-term and long-term toxicities have been identified. The short-term toxicities are myelosuppression, nausea and vomiting, pulmonary toxicity, nephropathy, and neuropathy. The longer term toxicities often discussed are ototoxicity, impairment of fertility, persistent neuropathy or ototoxicity, cardiovascular diseases, and secondary malignancies, which are all described in this review.
Sweeney
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Department of Medicine, Indiana University Medical Center, Indianapolis, USA.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D001853:Bone Marrow / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D018237:Germinoma / Q000188:drug therapy* / Q000556:secondary; D006311:Hearing Disorders / Q000139:chemically induced; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D009325:Nausea / Q000139:chemically induced; D009422:Nervous System Diseases / Q000139:chemically induced; D013736:Testicular Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects; D014839:Vomiting / Q000139:chemically induced
D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide; D002945:Cisplatin