title: [Involvement of peripheral 5-HT2A receptor activation in inflammatory pain].
abstract: Serotoninergic neuron is concerned as an one of the pivotal factor of the tissue inflammation which lead to pain behavior. Sarpogrelate HCl is a novel compound which may modulate inflammatory reaction through 5-HT2A receptor antagonist. We show the involvement of the 5-HT2A receptor activity in the inflammatory and neuropathic pain. Systemic or local sarpogrelate administration provokes antinociceptive effect on 5-HT- or formalin-produced inflammatory pain behaviour in relation to spinal glutamate. Local sarpogrelate inhibits apoptosis and neuronal degeneration after chronic construction injury(CCI). These effects are reversed by 5-HT2A receptor agonist. These results suggests sarpogrelate has a beneficial effect on hyperalgesia and neuropathic pain via inhibiting 5-HT2A receptor.
authors.affiliation: Department of Dental Anesthesiology, Kyushu Dental College.
authors.forename: O
authors.initials: O
authors.lastname: Nakanishi
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000818:Animals; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy / Q000209:etiology*; D020078:Neurogenic Inflammation / Q000188:drug therapy / Q000209:etiology*; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D013386:Succinates / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013386:Succinates; C064294:sarpogrelate