An octyl-2-cyanoacrylate formulation speeds healing of partial-thickness wounds.
BACKGROUND
Occlusive dressings have been known to accelerate the rate of healing. Every year new dressings are being introduced in the marketplace.


OBJECTIVE
The purpose of this study was to evaluate the effect of a new octyl-2-cyanoacrylate liquid dressing as compared to two over-the-counter bandages on partial-thickness wounds. Performance parameters were epithelialization, erythema, scab formation, material adherence, hemostasis, and infection.


METHODS
Eight pigs with a total of 645 partial-thickness wounds were assigned to one of the following treatments: liquid dressing, standard bandage, hydrocolloid bandage, or untreated air exposed.


RESULTS
The liquid bandage enhanced the rate of epithelialization and was the only treatment to provide complete hemostasis, reduced scab formation, and did not induce an irritant response (erythema) or infection.


CONCLUSIONS
The liquid bandage is an easy to use material that stops bleeding (instantaneous hemostasis) while enhancing healing of partial-thickness wounds.
Davis
S C
SC
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA. sdavis@med.miami.edu
Eaglstein
W H
WH
Cazzaniga
A L
AL
Mertz
P M
PM
D000818:Animals; D001458:Bandages; D003487:Cyanoacrylates / Q000494:pharmacology*; D005260:Female; D006487:Hemostasis; D009779:Occlusive Dressings; D012867:Skin / Q000187:drug effects / Q000293:injuries / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000473:pathology
D003487:Cyanoacrylates; C119247:octylcyanoacrylate