title: Primary meningococcal arthritis in a prosthetic knee joint.
abstract: Neisseria meningitidis is known to cause a spectrum of diseases, including bacteraemia without sepsis, meningococcaemia without meningitis, meningitis with or without meningococcaemia, and chronic meningococcaemia. Less common manifestations of meningococcal infection include pharyngitis, pneumonia, pericarditis, urethritis and arthritis. To our knowledge, there have been no previous reports of N. meningitidis causing prosthetic joint infection. Herein, we report a case of primary meningococcal arthritis in a woman with a prosthetic knee joint. After surgical drainage the prosthesis was retained and the patient received appropriate and prolonged antibiotic treatment. The outcome was favourable, as with primary meningococcal arthritis affecting native joints.
authors.affiliation: Yale University School of Medicine, New Haven, CT 06520-8022, USA.
authors.forename: H R
authors.initials: HR
authors.lastname: Vikram
authors.forename: R B
authors.initials: RB
authors.lastname: Buencamino
authors.forename: S I
authors.initials: SI
authors.lastname: Aronin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D002437:Cefazolin / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004322:Drainage; D005260:Female; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D008589:Meningococcal Infections / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D009345:Neisseria meningitidis / Q000302:isolation & purification*; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy
chemical_list: D002511:Cephalosporins; D002437:Cefazolin