title: [Results of radiotherapy and combined, comprehensive treatment of pancreatic cancer].
abstract: The results of irradiation, combined and complex treatment of pancreatic cancer have been evaluated versus stage, site and extent of surgery. Radiotherapy was carried out in 63 patients (1988-1999): prior to gastropancreaticoduodenectomy (GPDE)--7; after GPDE--12; for local recurrence after GPDE--4, before and after left-sided resection--4, before and after conservative surgery--19, and after diagnostic verification (exploratory laparotomy or ultrasound-controlled fine-needle biopsy)--17. Diagnosis was established on the basis of clinical data and case histories, ultrasonographic, CT, histological, cytological, biopsy, blood serum-marker CA 19-9 and CEA findings. Two months after treatment, complete remission was registered in 5 (13%), partial response--5 (13%), stabilization--13 (33%), tumor progression--16 (41%). Before and after GPDE, tolerance to radiotherapy was sufficient. Median survival in this group was 12.9 months, controls--8.1 months; for conservative surgery--7.3 and 4.1 months, respectively; radiotherapy + exploratory laparotomy alone--16.8 and 4.3 months, respectively. Irradiation of locally-advanced tumors of the body and/or tail of pancreas proved effective: median survival was 7.3 months, control--2.2 months. Hence, radiotherapy made an important contribution to treatment of locally-advanced and resectable pancreatic tumors and longer survival.
authors.affiliation: I.P. Pavlov State Medical University, St. Petersburg.
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Kokhanenko
authors.forename: V I
authors.initials: VI
authors.lastname: Amosov
authors.forename: A M
authors.initials: AM
authors.lastname: Ignashov
authors.forename: T S
authors.initials: TS
authors.lastname: Gladinova
authors.forename: O N
authors.initials: ON
authors.lastname: Volkov
authors.forename: I A
authors.initials: IA
authors.lastname: Ignat'eva
authors.forename: E S
authors.initials: ES
authors.lastname: Iakovleva
authors.forename: S K
authors.initials: SK
authors.lastname: Osipenko
authors.forename: V M
authors.initials: VM
authors.lastname: Savrasov
authors.forename: I B
authors.initials: IB
authors.lastname: Tabidze
authors.forename: E R
authors.initials: ER
authors.lastname: Sopiia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D001707:Biopsy, Needle; D018450:Disease Progression; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor