Antioxidative and antitumor promoting effects of [6]-paradol and its homologs.
Recently, considerable attention is focused on anti-carcinogenic phytochemicals, particularly those derived from medicinal or edible plants. [6]-Paradol, a pungent phenolic compound present in certain Zingiberaceae plants, is known to have antimicrobial and analgesic activities. The compound has been reported to attenuate promotion of skin carcinogenesis and TPA-induced ear edema in female ICR mice, and to induce apoptosis in cultured human promyelocytic leukemia (HL-60) cells. In this study, we performed several biochemical studies to evaluate and compare the cancer chemopreventive potential of [6]-paradol and its synthetic derivatives. [6]-Paradol and its synthetic nonpungent analog, [6]-dehydroparadol significantly decreased the incidence and the multiplicity of skin tumors initiated by 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA). Topical application of [6]-paradol and its derivatives inhibited TPA-induced ear edema and H(2)O(2) production and myeloperoxidase activity in the dorsal skin of mice. Induction of TPA-induced mouse epidermal ornithine decarboxylase (ODC) activity and H(2)O(2)- and UV-induced formation of oxidized DNA bases in vitro were also attenuated by the above compounds. These results indicate that [6]-paradol and its derivatives possess the cancer chemopreventive potential.
Chung
W Y
WY
Department of Oral Biology, Yonsei University College of Dentistry, 134 Shinchon-Dong, Seodaemoon-Ku, 120-752, Seoul, South Korea.
Jung
Y J
YJ
Surh
Y J
YJ
Lee
S S
SS
Park
K K
KK
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002273:Carcinogens / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects; D004431:Ear, External / Q000187:drug effects / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D004817:Epidermis / Q000187:drug effects / Q000201:enzymology; D005260:Female; D006139:Guaiacol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006861:Hydrogen Peroxide / Q000378:metabolism; D007659:Ketones / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008813:Mice, Inbred ICR; D009955:Ornithine Decarboxylase / Q000096:biosynthesis; D009195:Peroxidase / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D002273:Carcinogens; D007659:Ketones; D015127:9,10-Dimethyl-1,2-benzanthracene; D006139:Guaiacol; D006861:Hydrogen Peroxide; C421614:6-paradol; D009195:Peroxidase; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate