Characterisation of thymus-derived regulatory T cells that protect against organ-specific autoimmune disease.
Immunological tolerance to self is, in part, an active process mediated by a certain population of T lymphocytes. Our own work on the origin, phenotypic characterisation and mode of action of these regulatory T cells in rats forms the main focus of this review.
Stephens
L A
LA
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Mason
D
D
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D004195:Disease Models, Animal; D015536:Down-Regulation; D006801:Humans; D009928:Organ Specificity; D051381:Rats; D017634:Self Tolerance; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology*