Synthesis and base pairing properties of 9-deazapurine N7-nucleosides in oligonucleotide duplexes and triplexes.
The 9-deazaguanine N7-2'-deoxyribofuranoside (3) as well as the bromo and iodo derivatives 4a,b were synthesized and incorporated in oligonucleotide duplexes and triplexes. Their base pairing properties were investigated and compared with those of the parent purine N7-2'-deoxyribofuanosides.
Leonard
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P
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
Wiglenda
T
T
Seela
F
F
D020029:Base Pairing; D004247:DNA / Q000737:chemistry; D006031:Glycosylation; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*
D009841:Oligonucleotides; D011684:Purine Nucleosides; C051802:triplex DNA; D006147:Guanine; C076777:9-deazaguanine; D004247:DNA