title: Sperm disposal system in spermatic granuloma: a link with superoxide radicals.
abstract: Spermatic granulomas are believed to maintain "physiological harmony" in the male reproductive tract by maintaining a balance of hydrostatic pressure post-vasectomy. The mechanism for the disposal of deposited spermatozoa in the granuloma core is not clear. A fourfold rise in the production of superoxide along with ascorbyl and dienyl radicals and a 50% drop in the production of nitric oxide (NO) radicals by granuloma tissue hints that a reaction between NO and superoxide radicals could lead to the formation of peroxynitrite species which may contribute to the disposal of spermatozoa in the granuloma core. A higher protease activity and low hypoxanthine content in the granuloma indicates that a free radical driven sperm disposal system is active in granulomas.
authors.affiliation: School of Life Sciences, Devi Ahilya University, Indore, India. chattopadhyay.subhra@mayo.edu
authors.forename: S
authors.initials: S
authors.lastname: Chatterjee
authors.forename: M M
authors.initials: MM
authors.lastname: Rahman
authors.forename: M
authors.initials: M
authors.lastname: Laloraya
authors.forename: G P
authors.initials: GP
authors.lastname: Kumar
mesh_terms: D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D010450:Endopeptidases / Q000378:metabolism; D005832:Genital Diseases, Male / Q000378:metabolism* / Q000473:pathology; D006099:Granuloma / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D013094:Spermatozoa; D013481:Superoxides / Q000378:metabolism*; D014649:Vas Deferens / Q000201:enzymology; D014659:Vasectomy
chemical_list: D013481:Superoxides; D009569:Nitric Oxide; D010450:Endopeptidases