Methamphetamine effects on cognitive processing during extended wakefulness.
We examined the effects of both 5- and 10-mg/7O kg body weight of d-methamphetamine HCl on high event rate vigilance and tracking performance in a 13.5-hr sustained-performance session during one night of sleep loss. At 0116 hours participants were administered either a 5 mg/70 kg oral dose of d-methamphetamine (n=10), 10 mg/70 kg d-methamphetamine (n=10), or a placebo (n=10) using standard double-blind procedures. Performance on all measures degraded markedly during the night in the placebo group. Both the 5- and 10-mg methamphetamines treatment reversed an initial decline in d', and reversed increases in nonresponses (lapses) and tracking error within approximately 3 hr of administration. No evidence that amphetamine treatment increased impulsive responding (fast guesses) was observed. The magnitude of the performance effects of the methamphetamine treatments was similar at 3 hr postadministration. However, the effects of the 5-mg dose were shorter-lived, disappearing by the last testing session (6.5 hr postadministration), whereas effects of the 10-mg dose tended to remain throughout testing. Both amphetamine treatments decreased subjective sleepiness during the night and tended to increase subjective sleep latencies during a post-testing sleep period.
Wiegmann
D A
DA
Naval Aerospace Medical Research Laboratory, Pensacola, Florida, USA.
Stanny
R R
RR
McKay
D L
DL
Neri
D F
DF
McCardie
A H
AH
D000328:Adult; D001143:Arousal / Q000187:drug effects*; D001288:Attention; D001364:Awareness / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005221:Fatigue / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D008694:Methamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D008889:Military Personnel / Q000523:psychology*; D011930:Reaction Time / Q000187:drug effects; D012892:Sleep Deprivation / Q000502:physiology; D013647:Task Performance and Analysis; D013997:Time Factors; D014481:United States; D014851:Wakefulness / Q000187:drug effects*
D008694:Methamphetamine