Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models.
Populations of humans and mice contain alleles at many loci that protect from immune-mediated diseases. Identification of these alleles, some which are likely to function in immune recognition, tolerance, and regulation, will facilitate the development of diagnostics as well as therapeutics that alter disease progression.
Todd
J A
JA
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom. john.todd@cimr.cam.ac.uk
Wicker
L S
LS
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000628:therapy; D004195:Disease Models, Animal; D005802:Genes, MHC Class II; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007328:Insulin; D005810:Multigene Family; D011384:Proinsulin / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics
D006683:HLA-DQ Antigens; D007328:Insulin; D011498:Protein Precursors; C013737:preproinsulin; D011384:Proinsulin