title: Arrhythmicity in a child with septo-optic dysplasia and establishment of sleep-wake cyclicity with melatonin.
abstract: We identified a 3-year-old child with septo-optic dysplasia with arrhythmic activity patterns. To assess whether melatonin could improve rest-activity patterns, 0.1 mg was administered orally at 19:00 hours. After therapy onset, normal rest-activity patterns appeared. These observations show that melatonin can restore normal rhythmicity in the absence of a normally functioning circadian clock.
authors.affiliation: Department of Pediatrics, Interdepartmental Neuroscience Program in Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Rivkees
mesh_terms: D002675:Child, Preschool; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008550:Melatonin / Q000627:therapeutic use*; D020178:Sleep Disorders, Circadian Rhythm / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D016166:Free Radical Scavengers; D008550:Melatonin