title: Reduced bone mineral density in HIV-positive individuals.
abstract: A total of 105 HIV-positive patients underwent dual-energy X-ray absorbtiometry (DEXA) scan to assess bone mineral density (BMD). The prevalence of reduced BMD was found to be 71% and was higher in patients who had ever been treated with protease inhibitors (PI). Our results suggest a possible association between PI and reduced BMD, and further complicate the debate regarding when to commence treatment of HIV and with what agents to start.
authors.affiliation: Centre for HIV Medicine, Royal Free Hospital, London, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Moore
authors.forename: A
authors.initials: A
authors.lastname: Vashisht
authors.forename: C A
authors.initials: CA
authors.lastname: Sabin
authors.forename: A
authors.initials: A
authors.lastname: Mocroft
authors.forename: S
authors.initials: S
authors.lastname: Madge
authors.forename: A N
authors.initials: AN
authors.lastname: Phillips
authors.forename: J W
authors.initials: JW
authors.lastname: Studd
authors.forename: M A
authors.initials: MA
authors.lastname: Johnson
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000009:adverse effects*
chemical_list: D011480:Protease Inhibitors