title: Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.
abstract: Capsanthin and related carotenoids isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester and capsorbin diester showed strong inhibitory effects. Furthermore, capsanthin , capsanthin 3'-ester and capsanthin 3,3'-diester , major carotenoids in paprika, exhibited potent anti-tumor-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter.
authors.affiliation: Research Institute for Production Development, 15 Shimogamo-Morimoto-cho, Sakyo-ku, 606-0805, Kyoto, Japan. maoka@mbox.kyoto-inet.or.jp
authors.forename: T
authors.initials: T
authors.lastname: Maoka
authors.forename: K
authors.initials: K
authors.lastname: Mochida
authors.forename: M
authors.initials: M
authors.lastname: Kozuka
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: F
authors.initials: F
authors.lastname: Enjo
authors.forename: M
authors.initials: M
authors.lastname: Ogata
authors.forename: Y
authors.initials: Y
authors.lastname: Nobukuni
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Nishino
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects; D002212:Capsicum / Q000737:chemistry*; D002338:Carotenoids / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D024341:Xanthophylls
chemical_list: D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D024341:Xanthophylls; D002338:Carotenoids; C006889:capsanthin