[Immunohistochemical localization of insulin-like-growth-factor-binding protein 6 in the head area of the mouse].
BACKGROUND
The insulin-like growth factor (IGF) system is an important regulator of cell growth and differentiation. The mitogenic and metabolic activities of IGFs are modulated by a family of six high-affinity IFG binding proteins (IGFBPs). IGFBP-6 is unique among the IGFBPs in its preferential binding of IGF II.


METHODS
In this study, specific antibodies against recombinant mouse IGFBP-6 generated in chicken were used to localize IGFBP-6 by immunohistochemistry in the head region during late embryonic and newborn mice.


RESULTS
Immunoreactivity was detected in oral and nasal mucosa, tooth-forming anlage, anlage of skeletal muscle, anlage of submandibular glands, enchondral ossification, and osteoclasts.
Putzer
P
P
Klinik für Mund-, Kiefer- und Gesichtschirurgie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover. Putzer.Phillip@mh-hannover.de
Götz
W
W
Dempf
R
R
Braulke
T
T
D000818:Animals; D000831:Animals, Newborn; D002645:Chickens; D003429:Cross Reactions; D005260:Female; D005865:Gestational Age; D006257:Head / Q000196:embryology*; D006801:Humans; D018976:Insulin-Like Growth Factor Binding Protein 6 / Q000032:analysis*; D051379:Mice; D011247:Pregnancy; D011994:Recombinant Proteins
D018976:Insulin-Like Growth Factor Binding Protein 6; D011994:Recombinant Proteins