Changes in human adrenal and gonadal function onboard Spacelab.
Astronauts have to face chronic stress during the mission period. This might cause: (i) increased adrenocortico-trophin (ACTH) and cortisol (Cort) secretion; (ii) impaired luteinizing hormone (LH) output with consequent testosterone (T) hyposecretion in men. Moreover, should the subjects prove not to synchronize their inner clocks to the time shift protocols defined by NASA, most results would be questionable. The aim of this study was to verify if plasma testicular androgens were lower than baseline and Cort biorhythm was preserved in male astronauts during a short duration flight.
Strollo
F
F
INRCA, Italian National Research Centers on Ageing, Endocrine Unit, Rome, Italy.
Strollo
G
G
More
M
M
Ferretti
C
C
Mangrossa
N
N
Casarosa
E
E
Luisi
M
M
Riondino
G
G
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D000735:Androstenedione / Q000097:blood / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008297:Male; D012463:Saliva / Q000378:metabolism; D013026:Space Flight; D013312:Stress, Physiological / Q000378:metabolism; D013739:Testosterone / Q000097:blood / Q000378:metabolism; D014893:Weightlessness
D015113:Androstane-3,17-diol; C028895:androstane-3,17-diol glucuronide; D013739:Testosterone; D000735:Androstenedione; D019314:Dehydroepiandrosterone Sulfate; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D006854:Hydrocortisone