Structure-activity relationships of apio nucleosides as potential antiviral agents.
Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.
Jeong
L S
LS
College of Pharmacy, Ewha Womans University, Seoul, Korea.
Moon
H R
HR
Hong
J H
JH
Yoo
S J
SJ
Choi
W J
WJ
Kim
H O
HO
Ahn
H S
HS
Baek
H W
HW
Chun
M W
MW
Kim
H D
HD
Kim
J
J
Choi
J R
JR
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D015224:Dideoxynucleosides