title: Complications of orthotopic liver transplantation: spectrum of findings with helical CT.
abstract: Orthotopic liver transplantation has become the treatment of choice for patients with end-stage nonmalignant liver disease. The surgical techniques and immunosuppressive therapy for this procedure have improved considerably. Nevertheless, there are still significant complications, particularly those of vascular origin, which can lead to graft failure and require retransplantation unless prompt treatment is instituted. These complications include arterial and venous thrombosis and stenosis; arterial pseudoaneurysm; biliary leakage, stricture, and obstruction; liver ischemia, infarction, and abscess; fluid collections and hematomas; lymphoproliferative disorders; recurrent tumors; hepatitis C virus infection; and splenic infarction. Since the clinical presentation of posttransplantation complications is frequently nonspecific and varies widely, imaging studies are critical for early diagnosis. Helical computed tomography (CT) is a valuable complement to ultrasonography (US) in the postoperative period and is a safe, accurate, and noninvasive method of demonstrating hepatic vessels (hepatic artery, portal vein, hepatic veins, and inferior vena cava) and evaluating nonvascular complications (in the hepatic parenchyma and bile duct abnormalities) and extrahepatic tissues. Knowledge and early recognition of these complications is essential for graft salvage, and CT can provide valuable information, particularly for patients with indeterminate US results or in whom US examination is difficult.
authors.affiliation: Department of Radiology and Institut de Diagnòstic per la Imatge, Hospital General Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain. squiroga@hg.vhebron.es
authors.forename: S
authors.initials: S
authors.lastname: Quiroga
authors.forename: M C
authors.initials: MC
authors.lastname: Sebastià
authors.forename: C
authors.initials: C
authors.lastname: Margarit
authors.forename: L
authors.initials: L
authors.lastname: Castells
authors.forename: R
authors.initials: R
authors.lastname: Boyé
authors.forename: A
authors.initials: A
authors.lastname: Alvarez-Castells
mesh_terms: D017541:Aneurysm, False / Q000000981:diagnostic imaging; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000098:blood supply; D016031:Liver Transplantation / Q000000981:diagnostic imaging*; D009369:Neoplasms / Q000000981:diagnostic imaging; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging; D011169:Portal Vein / Q000000981:diagnostic imaging; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D013927:Thrombosis / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging