title: June 2001: 61 year old woman with confusion and obtundation.
abstract: The June COM. A 61 year old female presents with a three week history of increasing confusion, lethargy and headache. A neurological exam revealed disorientation, mild expressive aphasia, bilateral papilledema, and a right pronator drift. She had a craniotomy and resection of tumor. The tumor histologically was consistent with a solitary fibrous tumor displaying malignant features of hypercellularity, marked nuclear atypia, high mitotic activity, and a high proliferation index. This case is unique as the first malignant variant of solitary fibrous tumor to be reported intracranially.
authors.affiliation: Department of Pathology, University of Western Ontario.
authors.forename: J
authors.initials: J
authors.lastname: Barron
authors.forename: S P
authors.initials: SP
authors.lastname: Lownie
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
authors.forename: R R
authors.initials: RR
authors.lastname: Hammond
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy / Q000648:ultrastructure; D003221:Confusion / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D003704:Dementia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D002532:Intracranial Aneurysm / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000473:pathology / Q000628:therapy / Q000648:ultrastructure; D019635:Neurosurgical Procedures; D009880:Ophthalmic Artery / Q000473:pathology / Q000503:physiopathology; D020221:Optic Nerve Injuries / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor