Role of various types of serotonin receptors in regulation of drinking behavior and salt appetite in vasopressin-deficient brattleboro rats.
Serotonin 5-HT(1A)receptor agonist 8-OH DPAT suppressed drinking behavior in Brattleboro and Wistar rats. 5-HT(1B)agonist CGS-12066A and 5-HT(2A)antagonist ketanserin did not affect drinking behavior in Brattleboro rats; 5-HT(3)antagonist ondansetron suppressed water consumption and 5-HT(1A)agonist stimulated salt appetite in Brattleboro, but not in Wistar rats. Presumably, vasopressin regulates thirst and salt appetite by modulating sensitivity/density of various types of 5-HT receptors.
Naumenko
K S
KS
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk. naumenko@ bionet.nsc.ru
Popova
N K
NK
Ivanova
L N
LN
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects; D008297:Male; D017294:Ondansetron / Q000494:pharmacology; D051381:Rats; D011910:Rats, Brattleboro; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000502:physiology*; D012492:Salts; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013045:Species Specificity; D013894:Thirst / Q000187:drug effects; D013997:Time Factors; D014667:Vasopressins / Q000096:biosynthesis
D011985:Receptors, Serotonin; D012492:Salts; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D014667:Vasopressins; D017294:Ondansetron; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin