Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity.
Thieno analogues of the potent and selective furo-pyrimidine anti-VZV nucleoside family are herein reported. The compounds retain full antiviral potency in comparison to the furo parent.
Brancale
A
A
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, CF10 3XF, Cardiff, UK.
McGuigan
C
C
Algain
B
B
Savy
P
P
Benhida
R
R
Fourrey
J L
JL
Andrei
G
G
Snoeck
R
R
De Clercq
E
E
Balzarini
J
J
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006564:Herpesviridae / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D009705:Nucleosides / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry* / Q000493:pharmacokinetics*
D000998:Antiviral Agents; D009705:Nucleosides; D011743:Pyrimidines; D013876:Thiophenes