[Experimental study of photodynamic effect on bacterial wound microflora].
The in vitro study of the influence of photodynamic action (with the use of photosensitizer "Photosens", laser and non-laser irradiation) on the strains of the main representatives purulent wound microflora was carried out. Staphylococcus aureus, S. epidermidis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis cultures have been isolated from wound secretions and identified. The photosensitizer was shown to produce no bactericidal effect by itself. Irradiation with laser and non-laser light sources induced a sharp decrease in the number of viable cells in the cultures under study. The irradiation of the photosensitizer led to its activation, manifested in bactericidal action. The results thus obtained confirm good prospect of using photodynamic therapy for the treatment of purulent wounds.
Tolstykh
P I
PI
State Research Center of Laser Medicine, Vishnevsky Research Institute of Surgery, State Medico-Stomatological University, Moscow, Russia.
Stranadko
E F
EF
Koraboev
U M
UM
Urinov
A Ia
AIa
Tolstykh
M P
MP
Terekhova
R P
RP
Volkova
N N
NN
Duvanskiĭ
V A
VA
D001419:Bacteria / Q000254:growth & development / Q000302:isolation & purification / Q000528:radiation effects*; D015169:Colony Count, Microbial; D007211:Indoles / Q000494:pharmacology*; D007834:Lasers; D008027:Light; D009942:Organometallic Compounds / Q000494:pharmacology*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*; D014947:Wounds and Injuries / Q000382:microbiology*
D007211:Indoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C048577:aluminum tetrasulfophthalocyanine