Track structure in biological models.
High-energy heavy ions in the galactic cosmic radiation (HZE particles) may pose a special risk during long term manned space flights outside the sheltering confines of the earth's geomagnetic field. These particles are highly ionizing, and they and their nuclear secondaries can penetrate many centimeters of body tissue. The three dimensional patterns of ionizations they create as they lose energy are referred to as their track structure. Several models of biological action on mammalian cells attempt to treat track structure or related quantities in their formulation. The methods by which they do this are reviewed. The proximity function is introduced in connection with the theory of Dual Radiation Action (DRA). The ion-gamma kill (IGK) model introduces the radial energy-density distribution, which is a smooth function characterizing both the magnitude and extension of a charged particle track. The lethal, potentially lethal (LPL) model introduces lambda, the mean distance between relevant ion clusters or biochemical species along the track. Since very localized energy depositions (within approximately 10 nm) are emphasized, the proximity function as defined in the DRA model is not of utility in characterizing track structure in the LPL formulation.
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Lawrence Berkeley Laboratory, Division of Biology and Medicine, University of California 94720, USA.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D003359:Cosmic Radiation; D006801:Humans; D018499:Linear Energy Transfer; D008954:Models, Biological; D009686:Nuclear Physics; D011853:Radiobiology; D012062:Relative Biological Effectiveness; D013269:Stochastic Processes