Turbinamide, a new selective cytotoxic agent from the Mediterranean tunicate Sidnyum turbinatum.
A unique cytotoxic metabolite, turbinamide (1), has been isolated from the marine tunicate Sidnyum turbinatum through a bioassay-guided approach. Its structure has been elucidated by an extensive spectroscopic analysis. Turbinamide demonstrated a strong and selective cytotoxic effect against neuronal cells rather than immune system cells. Structure: see text.
Aiello
A
A
Dipartimento di Chimica delle Sostanze Naturali and Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli Federico II, Via D. Montesano 49, I-80131 Naples, Italy.
Carbonelli
S
S
Esposito
G
G
Fattorusso
E
E
Iuvone
T
T
Menna
M
M
D000473:Alkanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009000:Monocytes / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
D000473:Alkanes; D000577:Amides; D000970:Antineoplastic Agents; C449319:turbinamide