title: [Effect of -6 degrees bed-rest on T-lymphocyte proliferation and cytokines production in human].
abstract: In this study, the effect of -6 degrees head-down bed-rest on proliferation of T lymphocyte stimulated by phytohemagglutinin, a kind of polyclone T cell activators and cytokines production were observed. The results showed: after 2 d bed-rest, proliferation of T lymphocyte stimulated by phytohemagglutinin decreased significantly; the activity of interleukin-2 trended to decrease; the expression of interleukin-2 receptor tended to increase; the production of interleukin-6 decreased significantly. After 6 d bed-rest, T lymphocyte proliferation restored to normal; the activity of interleukin-2 and expression of interleukin-2 receptor had no change; the production of interleukin-6 decreased significantly. This result demonstrated that -6 degrees bed-rest can decrease T lymphocyte proliferation function, and this decrease may be caused by the reduction of cytokines secretion.
authors.affiliation: Institute of Space Medico-Engineering, Beijing, China.
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Wen
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: P
authors.initials: P
authors.lastname: Hu
authors.forename: S
authors.initials: S
authors.lastname: Si
mesh_terms: D000328:Adult; D001510:Bed Rest; D018475:Head-Down Tilt; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D018655:Lymphocyte Count / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects*; D018474:Weightlessness Simulation
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6; D010835:Phytohemagglutinins; D015375:Receptors, Interleukin-2