Chemoselective approaches to glycoprotein assembly.
Oligosaccharides on proteins and lipids play central roles in human health and disease. The molecular analysis of glycoconjugate function has benefited tremendously from new methods for their chemical synthesis, which provides homogeneous material not attainable from biosynthetic systems. Still, glycoconjugate synthesis requires the manipulation of multiple stereocenters and protecting groups and remains the domain of a few expert laboratories around the world. This Account summarizes chemoselective approaches for assembling homogeneous glycoconjugates that attempt to reduce the barriers to their synthesis. The objective of these methods is to make glycoconjugate synthesis accessible to a broader community, thereby accelerating progress in glycobiology.
Hang
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Department of Chemistry, University of California, Center for Advanced Materials, Materials Sciences Division, Lawrence Berkeley National Laboratory, and Howard Hughes Medical Institute, Berkeley, California 94720, USA.
Bertozzi
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D002240:Carbohydrate Sequence; D006023:Glycoproteins / Q000096:biosynthesis / Q000138:chemical synthesis*; D006801:Humans; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000096:biosynthesis / Q000138:chemical synthesis; D015202:Protein Engineering
D006023:Glycoproteins; D009844:Oligosaccharides