Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside.
The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570 +/- 29 to 401 +/- 59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.
Miura
T
T
Department of Clinical Nutrition, Suzuka University of Medical Science, Mie, Japan. miura@suzuka-u.ac.jp
Ichiki
H
H
Iwamoto
N
N
Kato
M
M
Kubo
M
M
Sasaki
H
H
Okada
M
M
Ishida
T
T
Seino
Y
Y
Tanigawa
K
K
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D005960:Glucosides / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014044:Tolbutamide / Q000494:pharmacology; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
D005960:Glucosides; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin; D014044:Tolbutamide