Delineating the genetic basis of systemic lupus erythematosus.
Genetic predisposition plays a crucial role in susceptibility to systemic lupus erythematosus (SLE) in both human patients and animal models. Recent progress in experimental systems and human linkage analysis is providing key insights into the genetic basis for susceptibility and elucidating the manner in which genetic interactions mediate severe disease pathogenesis. Genes in multiple pathways appear to participate in specific elements of the disease, and epistatic interactions among these genes play an important role in both aggravating and suppressing disease development.
Wakeland
E K
EK
Center for Immunology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA. edward.wakeland@email.swmed.edu
Liu
K
K
Graham
R R
RR
Behrens
T W
TW
D015551:Autoimmunity; D002874:Chromosome Mapping; D003181:Complement C4 / Q000235:genetics; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics
D003181:Complement C4; D006680:HLA Antigens; D017452:Receptors, IgG