title: Redesigning nucleic acids.
abstract: A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit genetic information. Oligonucleotides (as opposed to nucleosides) have long been overlooked by synthetic organic chemists as targets for structural modification. Synthetic chemistry has now yielded oligonucleotides with 12 replicatable letters, modified backbones, and new insight into why Nature chose the oligonucleotide structures that she did.
authors.affiliation: Department of Chemistry, University of Florida, Gainesville 32611, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Benner
authors.forename: T R
authors.initials: TR
authors.lastname: Battersby
authors.forename: B
authors.initials: B
authors.lastname: Eschgfaller
authors.forename: D
authors.initials: D
authors.lastname: Hutter
authors.forename: J T
authors.initials: JT
authors.lastname: Kodra
authors.forename: S
authors.initials: S
authors.lastname: Lutz
authors.forename: T
authors.initials: T
authors.lastname: Arslan
authors.forename: D K
authors.initials: DK
authors.lastname: Baschlin
authors.forename: M
authors.initials: M
authors.lastname: Blattler
authors.forename: M
authors.initials: M
authors.lastname: Egli
authors.forename: C
authors.initials: C
authors.lastname: Hammer
authors.forename: H A
authors.initials: HA
authors.lastname: Held
authors.forename: J
authors.initials: J
authors.lastname: Horlacher
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
authors.forename: B
authors.initials: B
authors.lastname: Hyrup
authors.forename: T F
authors.initials: TF
authors.lastname: Jenny
authors.forename: S C
authors.initials: SC
authors.lastname: Jurczyk
authors.forename: M
authors.initials: M
authors.lastname: Konig
authors.forename: U
authors.initials: U
authors.lastname: von Krosigk
authors.forename: M J
authors.initials: MJ
authors.lastname: Lutz
authors.forename: L J
authors.initials: LJ
authors.lastname: MacPherson
authors.forename: S E
authors.initials: SE
authors.lastname: Moroney
authors.forename: E
authors.initials: E
authors.lastname: Muller
authors.forename: K P
authors.initials: KP
authors.lastname: Nambiar
authors.forename: J A
authors.initials: JA
authors.lastname: Piccirilli
authors.forename: C Y
authors.initials: CY
authors.lastname: Switzer
authors.forename: J J
authors.initials: JJ
authors.lastname: Vogel
authors.forename: C
authors.initials: C
authors.lastname: Richert
authors.forename: A L
authors.initials: AL
authors.lastname: Roughton
authors.forename: J
authors.initials: J
authors.lastname: Schmidt
authors.forename: K C
authors.initials: KC
authors.lastname: Schneider
authors.forename: J
authors.initials: J
authors.lastname: Stackhouse
mesh_terms: D002384:Catalysis; D003062:Codon; D004247:DNA / Q000737:chemistry*; D008967:Molecular Biology / Q000639:trends*; D015394:Molecular Structure; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry
chemical_list: D003062:Codon; D009696:Nucleic Acids; D009841:Oligonucleotides; D010710:Phosphates; D013450:Sulfones; D004247:DNA