Antiprogestagen activity of 5H-progesterone metabolites and their analogues, 16alpha,17alpha-cyclohexane-5H-pregnan-3,20-diones.
Antiprogestin activity of 5H-progesterone metabolites and their analogues 16alpha,17alpha-cyclohexan-5H-pregnan-3,20-diones was tested on rats. Modified pregnancy interruption test showed that 5alpha (H)-isomers of natural and synthetic hormones exhibit maximum activity.
Kareva
E N
EN
Department of Molecular Pharmacology and Radiobiology, Medical Biological Faculty of the Russian State Medical University, Moscow.
Kamernitskii
A V
AV
Levina
I S
IS
Kirpichnikova
N V
NV
Kulikova
L E
LE
Podval'nyuk
V V
VV
D000021:Abortifacient Agents, Steroidal / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D005260:Female; D015735:Mifepristone / Q000494:pharmacology; D015394:Molecular Structure; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000187:drug effects*; D011270:Pregnancy, Animal; D011280:Pregnanolone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism*; D011372:Progestins / Q000037:antagonists & inhibitors*; D051381:Rats
C445420:16,17-cyclohexane-5H-pregnan-3,20-dione; D000021:Abortifacient Agents, Steroidal; D011372:Progestins; D015735:Mifepristone; D011374:Progesterone; D011280:Pregnanolone