Isonucleosides incorporating universal bases.
Enantiomeric isodideoxynucleosides of the (S,S) and (R,R) families with the universal base, imidazole-4-carboxamide as the nucleobase, were synthesized as biological mimics of anti-HIV active D- and L-related isodideo-xyadenosines. In vitro anti-HIV evaluation in CEM cells of these target compounds showed that they were inactive. Further antiviral studies are in progress.
Nair
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V
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Sosnouski
D S
DS
Zhu
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Q
D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000737:chemistry*; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D018716:Molecular Mimicry; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; C032566:imidazole-4-carboxamide; D000620:Aminoimidazole Carboxamide