title: [Alterations of the form of M-response in polyneuropathies of different genesis].
abstract: The aim of the study was to identity main types of alterations in the form of M-responses in patients with primary axonal and demyelinating polyneuropathies (PNP). Clinical and electroneuromyographic examination was performed in 227 patients aged 15-72 years with alcoholic (axonal) and inflammatory demyelinating PNP. M-response was registered from the abductor pollicis brevis, abductor digitus minimum, short extensor of the hallux, and abductor hallucis during stimulation of the motor fibers of median, ulnar, tibial, peroneal nerves using superficial registration electrodes. The basis for selection of altered types of M-responses was the analysis of the following criteria: a spatial correlation of the positive and negative picks; presence of the additional crooks, turns and phases on M-responses; location of these changes on the curve. 5 types of M-response alterations were singled out. The first three types were revealed in patients with alcoholic PNP and two other types--in patients with inflammatory demyelinating PNP. These 5 types of the changes in M-responses reflect the degree of desynchronization in coming of the impulses to muscular fibers. Classification proposed allows to improve a quality of both diagnosis and control of therapy in patients with PNP of different genesis.
authors.forename: V I
authors.initials: VI
authors.lastname: Khodulev
authors.forename: N I
authors.initials: NI
authors.lastname: Nechipurenko
authors.forename: S V
authors.initials: SV
authors.lastname: Marchenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D020269:Alcoholic Neuropathy / Q000175:diagnosis* / Q000503:physiopathology*; D001369:Axons / Q000473:pathology; D004576:Electromyography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis* / Q000503:physiopathology*