Protein kinase C gamma-like immunoreactivity of trigeminothalamic neurons in the medullary dorsal horn of the rat.
We examined protein kinase C gamma-like immunoreactivity (PKCgamma-LI) of trigeminothalamic neurons in the rat medullary dorsal horn (MDH) after injecting a retrograde tracer, Fluoro-Gold (FG), into the thalamus. Over 90% of FG-labeled neurons in the marginal layer (lamina I) and a few FG-labeled neurons in the superficial part of the magnocellular layer (lamina III) showed PKCgamma-LI. No PKCgamma-neurons in the substantia gelatinosa (lamina II) were labeled with FG. PKCgamma-mediated regulation of trigeminothalamic neurons may contribute to the changes in MDH activity during persistent pain.
Li
Y Q
YQ
Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, 710032, Xi'an, PR China.
Li
J L
JL
Li
H
H
Kaneko
T
T
Mizuno
N
N
D000818:Animals; D002452:Cell Count; D007150:Immunohistochemistry; D020646:Intralaminar Thalamic Nuclei / Q000166:cytology / Q000201:enzymology; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D020644:Midline Thalamic Nuclei / Q000166:cytology / Q000201:enzymology; D009434:Neural Pathways / Q000166:cytology / Q000201:enzymology*; D009474:Neurons / Q000166:cytology / Q000201:enzymology*; D010146:Pain / Q000201:enzymology* / Q000503:physiopathology; D020656:Posterior Thalamic Nuclei / Q000166:cytology / Q000201:enzymology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013373:Substance P / Q000378:metabolism; D013376:Substantia Gelatinosa / Q000166:cytology / Q000201:enzymology; D009435:Synaptic Transmission / Q000502:physiology; D013788:Thalamus / Q000166:cytology / Q000201:enzymology*; D014275:Trigeminal Caudal Nucleus / Q000166:cytology / Q000201:enzymology*; D020651:Ventral Thalamic Nuclei / Q000166:cytology / Q000201:enzymology
D007527:Isoenzymes; D018040:Receptors, Neurokinin-1; D013373:Substance P; C087857:protein kinase C gamma; D011493:Protein Kinase C