[Parametric survival analysis in patients with cervical cancer following fractionated radiotherapy: a new procedures and results].
A recent theoretical result of Kendal (1998) enabled us to develop a survival model which allows for proliferation of tumor clonogenic cells in the course of fractionated radiotherapy. We explored this model during an analysis of clinical data on survival of 982 patients with cancer of the cervix uteri. The model provided a good description of survival patterns in different groups of patients. The estimated cure probability did not correlate with the rates of cell proliferation between exposures to radiation. Also, our results showed that this parameter cannot be estimated from survival data. Some light has been thrown on the relationship of cell proliferations taking place between exposures, on the one hand, and end-results of treatment for cancer of the cervix uteri, on the other.
Zorin
A V
AV
Central Research Institute of Roentgeno-Radiology, Ministry of Health of the RF, St. Petersburg.
Tsodikov
A D
AD
Khanin
L G
LG
Zharinov
G M
GM
Zaikin
G V
GV
Iakovlev
A Iu
AIu
D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000532:radiotherapy*