Medical management of primary hyperaldosteronism.
Most forms of primary aldosteronism are surgically correctable. However, when surgery is not appropriate, medical management is just as effective in correcting the pathophysiologic abnormalities due to aldosterone excess. A prerequisite for the rational medical management of primary aldosteronism is an understanding of the mechanisms that sustain hypertension. Primary aldosteronism can be associated with severe and resistant hypertension, and persistent hypervolemia is the primary reason for resistance to therapy. Patients with overriding comorbidities or strong preferences have been medically treated over the intermediate term of 5 to 7 years without evidence of escape or evidence of malignant transformation of adrenal adenomas.
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Department of Nephrology and Hypertension, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A51, Cleveland, OH 44195, USA.
D000236:Adenoma / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D000959:Antihypertensive Agents / Q000627:therapeutic use; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy
D000959:Antihypertensive Agents