Phospholipid composition of high-density lipoproteins reflects lipolysis of triglyceride-rich lipoproteins during hyperlipidemia.
We studied phospholipid composition of high-density lipoproteins in patients with normo- and hypertriglyceridemia treated with various hypolipidemic preparations (simvastatin and fenofibrate). Both preparations changed phospholipid composition of high-density lipoproteins and improved their functional activity. The differences in the phospholipid composition of high-density lipoproteins were probably related to lipolysis of triglyceride-rich lipoproteins catalyzed by lipoprotein lipase and, in particular, hepatic lipase.
Perova
N V
NV
Department of Metabolic Disorders, State Research Center of Preventive Medicine, Russian Ministry of Health, Moscow.
Ozerova
I N
IN
Paramonova
I V
IV
Olfer'ev
A M
AM
Akhmedzhanov
N M
NM
Pavlova
L I
LI
Oganov
R G
RG
D000328:Adult; D000924:Anticholesteremic Agents / Q000494:pharmacology; D002308:Cardiolipins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D011345:Fenofibrate / Q000494:pharmacology; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008066:Lipolysis; D008075:Lipoproteins, HDL / Q000097:blood*; D008244:Lysophosphatidylcholines / Q000097:blood; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood; D010714:Phosphatidylethanolamines / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D019821:Simvastatin / Q000494:pharmacology; D013109:Sphingomyelins / Q000097:blood; D014280:Triglycerides / Q000097:blood*
D000924:Anticholesteremic Agents; D002308:Cardiolipins; D008076:Cholesterol, HDL; C034396:HDL-triglyceride; D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D013109:Sphingomyelins; D014280:Triglycerides; C037978:high density lipoprotein phosphatidylcholine; D002784:Cholesterol; D019821:Simvastatin; D011345:Fenofibrate