Delineation of normal human left ventricular twist throughout systole by tagged cine magnetic resonance imaging.
Myofibril shortening and the oblique fiber orientation of the left ventricular myocardium results in a twisting motion of the left ventricle. Advances in cardiac magnetic resonance imaging (MRI) have made it possible to label the myocardium noninvasively and track this motion (twist) through the cardiac cycle, but little data exist on its complete systolic time course. The purpose of this study was to delineate the normal human systolic time course of ventricular twist using tagged cine-MRI. Tagged cine-MRI was performed in 10 healthy subjects. The mean systolic twist angle relative to the short axis centroid for the 10 volunteers was calculated. Interstudy and intra- and interobserver variability were assessed. During isovolumic contraction, all ventricular twist was counterclockwise. Later in systole, the basal segments changed direction and rotated in a clockwise direction, whereas the apical segments continued counterclockwise rotation. The midpoint for rotation was 45+/-8% of ventricular length. The mean short axis net ventricular twist (apex-base) at 80% systole was 12.6+/-1.5 degrees. The four wall segments showed heterogeneity in twist (lateral wall, 20.6+/-1.7 degrees; anterior wall, 17.5+/-5.1 degrees; inferior wall, 8.8+/-4.9 degrees; septum, 3.5+/-2.4 degrees). The anterior and lateral walls demonstrated significantly higher twist than the other walls (p < 0.01). Torsion increased steadily throughout systole after isovolumic contraction, whereas twist displayed rate changes. The mean interstudy and intra- and interobserver differences were less than 2.1 degrees. The close similarity in twist between subjects and the low interstudy and inter/intraobserver variation indicates that twist is a robust parameter of myocardial function. Torsion varies smoothly during systole, which may play a role in minimizing oxygen consumption. These data can serve as a baseline from which to compare alterations in regional myocardial function in disease.
Lorenz
C H
CH
Cardiovascular Division, Barnes-Jewish Hospital, Washington University Medical Center, St. Louis, Missouri, USA.
Pastorek
J S
JS
Bundy
J M
JM
D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D015203:Reproducibility of Results; D013599:Systole / Q000502:physiology*; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*