title: Internal jugular vein thrombosis following in-vitro fertilization in a woman with protein S deficiency and heterozygosity for the prothrombin 3' UTR mutation, despite anticoagulation with heparin.
abstract: We report the case of a 31-year-old woman with protein S deficiency and heterozygosity for the prothrombin 3' UTR mutation who developed an internal jugular vein thrombosis despite therapeutic anticoagulation with a low molecular weight heparin, following in-vitro fertilization. This case indicates that the stimulus to thrombosis in such women is intense and can occur despite apparent therapeutic anticoagulation. Close attention should, therefore, be paid to any women with a personal or family history of thrombosis and the potential thrombotic risks associated with assisted conception must be discussed.
authors.affiliation: Haemophilia Centre and Haemostasis Unit - Department of Haematology, Royal Free and University College Medical School, London, UK.
authors.forename: R V
authors.initials: RV
authors.lastname: Thomas
authors.forename: W
authors.initials: W
authors.lastname: Reid
authors.forename: D J
authors.initials: DJ
authors.lastname: Perry
mesh_terms: D020413:3' Untranslated Regions; D000022:Abortion, Spontaneous; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000627:therapeutic use; D006579:Heterozygote; D006801:Humans; D007601:Jugular Veins; D009154:Mutation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome; D018455:Protein S Deficiency / Q000150:complications*; D011516:Prothrombin / Q000235:genetics*; D020246:Venous Thrombosis / Q000209:etiology* / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D011516:Prothrombin