title: Individual sensitivity to genotoxic effects of nickel and antimutagenic activity of ascorbic acid.
abstract: Cytotoxicity of nickel compounds was studied by stimulating the repair synthesis of DNA and counting lymphocyte micronuclei in workers of smelting shop of copper-nickel sulfide processing plant. Nickel content in the organism was evaluated by its concentrations in hair. Therapy with ascorbic acid (1 g/day for 1 month) led to a significant decrease in the number of micronuclei. The number of micronuclei before and after ascorbic acid treatment varied within a wide range in different individuals.
authors.affiliation: Group of Medical Ecological Studies, Institute of Industrial Ecology Problems of the North, Karelian Research Center, Russian Academy of Sciences, Apatity.
authors.forename: I N
authors.initials: IN
authors.lastname: Perminova
authors.forename: T A
authors.initials: TA
authors.lastname: Sinel'shchikova
authors.forename: N I
authors.initials: NI
authors.lastname: Alekhina
authors.forename: E V
authors.initials: EV
authors.lastname: Perminova
authors.forename: G D
authors.initials: GD
authors.lastname: Zasukhina
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000378:metabolism; D000396:Air Pollutants, Radioactive / Q000009:adverse effects* / Q000378:metabolism; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004249:DNA Damage; D006197:Hair / Q000378:metabolism; D006801:Humans; D048629:Micronuclei, Chromosome-Defective; D009153:Mutagens / Q000009:adverse effects* / Q000378:metabolism; D009532:Nickel / Q000009:adverse effects* / Q000378:metabolism
chemical_list: D000395:Air Pollutants, Occupational; D000396:Air Pollutants, Radioactive; D016587:Antimutagenic Agents; D009153:Mutagens; D009532:Nickel; D001205:Ascorbic Acid