title: Results of space experiment program "Interferon".
abstract: The results of the biological space experiment "Interferon" performed by two international cosmonaut teams (26 May 1980, and 16 May 1981) aboard space laboratory Solyut-6 are reported: (1) Human lymphocytes separated from blood of healthy donors and placed into "Interferon I" equipment could be kept for 7 days in suspension culture under spaceflight conditions. Interferon production could be induced in human lymphocytes by preparations of different origin: virus, synthetic polyribonucleotides, bacterial protein and plant pigment. An increased lymphocyte interferon production in space laboratory compared to ground control was observed. (2) Human interferon preparations and interferon inducers placed in space laboratory at room temperature for 7 days maintained their biological activity. (3) A decrease of induced interferon production and natural killer activity of lymphocytes isolated from peripheral blood of cosmonauts was observed on the 1st day on Earth after 7-days spaceflight.
authors.affiliation: National Institute of Hygiene, Budapest, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Talas
authors.forename: L
authors.initials: L
authors.lastname: Batkai
authors.forename: I
authors.initials: I
authors.lastname: Stoger
authors.forename: K
authors.initials: K
authors.lastname: Nagy
authors.forename: L
authors.initials: L
authors.lastname: Hiros
authors.forename: I
authors.initials: I
authors.lastname: Konstantinova
authors.forename: M
authors.initials: M
authors.lastname: Rykova
authors.forename: I
authors.initials: I
authors.lastname: Mozgovaya
authors.forename: O
authors.initials: O
authors.lastname: Guseva
authors.forename: V
authors.initials: V
authors.lastname: Kozharinov
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology; D007370:Interferon Type I / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000502:physiology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013026:Space Flight; D014893:Weightlessness
chemical_list: D007369:Interferon Inducers; D007370:Interferon Type I