title: [Experimental evaluation of efficacy of Lactobacilli in prophylaxis and treatment of cholera].
abstract: Investigations on experimental models of cholera ("sealed" mice and suckling rabbits) demonstrated that previous daily oral administration of the ferment culture of Lactobacillus acidophilus BKM B-2020[symbol: see text] in a dose of 3.0 x 10(8) microbial cells/ml daily for 5-7 days prevented to the development of Vibrio cholerae infection. The curative effect observed after 3 administrations of lactobacilli within 48 hours after infection with V. cholerae was registered in 50% of cases. This strain of lactobacilli was found to be suitable for use as the basis component of probiotic, an additional remedy for the prophylaxis and treatment of cholera.
authors.affiliation: Research Institute for Plague Control, Rostov-on-Don, Russia.
authors.forename: I D
authors.initials: ID
authors.lastname: Bardykh
authors.forename: V D
authors.initials: VD
authors.lastname: Krylikov
authors.forename: B L
authors.initials: BL
authors.lastname: Mazrukho
authors.forename: I V
authors.initials: IV
authors.lastname: Ryzhko
authors.forename: E A
authors.initials: EA
authors.lastname: Moskvitina
authors.forename: R I
authors.initials: RI
authors.lastname: Tsuraeva
authors.forename: N I
authors.initials: NI
authors.lastname: Vinokur
authors.forename: N V
authors.initials: NV
authors.lastname: Drobotkovskaia
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D002771:Cholera / Q000517:prevention & control / Q000628:therapy*; D007779:Lactobacillus acidophilus; D051379:Mice; D019936:Probiotics / Q000627:therapeutic use*; D011817:Rabbits