Functional cross-talk of HIV-1 Tat with p53 through its C-terminal domain.
Human immunodeficiency virus type 1 (HIV-1) Tat repressed the p53-dependent gene expression through its C-terminal domain of Tat (amino acid residues 73-86) independent of the involvement of NF-kappaB and coactivator CBP/p300. Although Tat did not directly bind to p53, this repression required the N-terminal domain of p53. In contrast, Tat and p53 cooperated in the activation of HIV-1 gene expression. Thus, the cross-talk between Tat and p53 may be linked with cellular transformation by HIV-1 infection or activation of HIV-1 replication.
Ariumi
Y
Y
Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
Kaida
A
A
Hatanaka
M
M
Shimotohno
K
K
D000818:Animals; D019556:COS Cells; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D015696:Gene Products, tat / Q000737:chemistry / Q000494:pharmacology*; D020868:Gene Silencing; D016325:HIV Long Terminal Repeat / Q000502:physiology; D015497:HIV-1 / Q000737:chemistry* / Q000502:physiology; D016328:NF-kappa B / Q000378:metabolism; D017434:Protein Structure, Tertiary; D015533:Transcriptional Activation / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D016328:NF-kappa B; D016159:Tumor Suppressor Protein p53; D054322:tat Gene Products, Human Immunodeficiency Virus