title: Objective assessment of progression in Huntington's disease: a 3-year follow-up study.
abstract: Objective measures to assess progression of Huntington's disease (HD) are desirable. The authors have previously found that patients with HD with higher Unified Huntington's Disease Rating Scale (UHDRS) motor scores exhibited higher variability of isometric grip forces while grasping an object. Therefore, the authors assessed grip force variability during this task in 10 HD patients with a 3-year follow-up. Grip force variability increased in all patients at the follow-up. Thus, grip force variability during grasping might be an objective and quantitative measure to assess motor deficits associated with the progression of HD.
authors.affiliation: Department of Biobehavioral Sciences, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.
authors.forename: R
authors.initials: R
authors.lastname: Reilmann
authors.forename: F
authors.initials: F
authors.lastname: Kirsten
authors.forename: L
authors.initials: L
authors.lastname: Quinn
authors.forename: H
authors.initials: H
authors.lastname: Henningsen
authors.forename: K
authors.initials: K
authors.lastname: Marder
authors.forename: A M
authors.initials: AM
authors.lastname: Gordon
mesh_terms: D000704:Analysis of Variance; D018450:Disease Progression; D004421:Dystonia / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000503:physiopathology; D018709:Statistics, Nonparametric