Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides.
Nuclear accumulation of ODNs has been associated with their binding to a series of nuclear proteins. These interactions could be responsible for the sequence-independent effects of ODNs as well as for their sequence-specific interactions and their intracellular distribution. Investigation of interaction of ODNs with these proteins may shed light on the mechanisms of cellular uptake and nuclear accumulation of oligonucleotides.
Tomasi
V
V
Laboratory of Nucleic Acids Biochemistry, Novosibirsk Institute of Bioorganic Chemistry, 8 Lavrentiev Ave., Novosibirsk, 630090, Russia.
Laktionov
P P
PP
Bryksin
A V
AV
Volod'ko
N V
NV
Griffoni
C
C
Rykova
E Y
EY
Spisni
E
E
Kraft
R
R
Vlassov
V V
VV
D001667:Binding, Competitive; D002467:Cell Nucleus / Q000378:metabolism; D004727:Endothelium / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D009000:Monocytes / Q000201:enzymology / Q000378:metabolism; D009841:Oligonucleotides / Q000493:pharmacokinetics* / Q000494:pharmacology
D009841:Oligonucleotides; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases