title: Beta3-adrenoceptor is involved in the inhibition of small intestinal motility due to restraint stress in rats.
abstract: We have reported that acute restraint stress inhibits small intestinal motility in rats. In order to clarify this inhibitory mechanism, we examined the effects of alpha- and beta-adrenergic antagonists on the inhibition of small intestinal motility induced by restraint stress. This inhibition underwent recovery by propranolol (beta1/beta2-antagonist) or SR59230A (beta3-antagonist), but not by atenolol (beta1-antagonist), ICI-118,551 (beta2-antagonist), prazosin (alpha1-antagonist) or yohimbine (alpha2-antagonist). These results suggest that beta3-adrenoceptors play an important role in the inhibition of small intestinal motility caused by restraint stress.
authors.affiliation: Department of Radiopharmacy, Tohoku Pharmaceutical University, Sendai, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Tsukada
authors.forename: M
authors.initials: M
authors.lastname: Sugawara
authors.forename: K
authors.initials: K
authors.lastname: Sawamura
authors.forename: Y
authors.initials: Y
authors.lastname: Ohuchi
authors.forename: H
authors.initials: H
authors.lastname: Kohno
authors.forename: Y
authors.initials: Y
authors.lastname: Ohkubo
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D007202:Indicators and Reagents; D007421:Intestine, Small / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D022702:Receptors, Adrenergic, beta-3 / Q000187:drug effects / Q000502:physiology*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D007202:Indicators and Reagents; D022702:Receptors, Adrenergic, beta-3