Inhibitory effects of licoisoflavones A and B and sophoraisoflavone A of Sophra mooracroftiana Beth ex Baker on copper-ion-induced protein oxidative modification of mice brain homogenate, in vitro.
We present the results of an in vitro investigation of the inhibitory effects of licoisoflavones A and B and sophoraisoflavone A isolated from Sophra mooracroftiana BETH ex BAKER on copper-induced protein oxidative modification of mice brain homogenate in vitro. Although inhibitory effect of sophoraisoflavone A was stronger than those of licoisoflavones A and B, genistein as a related isoflavone, and mannitol as a hydroxy radical scavenger, inhibitory effects of licoisoflavones A and B were weaker than those of genistein and mannitol. These results demonstrated that the difference of inhibitory effects are dependent on the relation between chemical structures of these isoflavones, such as hydroxy group or benzopyran, and oxidative stress.
Toda
S
S
Department of Pharmaceutical Science, Kansai College of Oriental Medicine, Osaka, Japan.
Shirataki
Y
Y
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D005609:Free Radicals; D020128:Inhibitory Concentration 50; D007477:Ions; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008956:Models, Chemical; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism*; D010944:Plants / Q000737:chemistry
D000975:Antioxidants; D005609:Free Radicals; D007477:Ions; D007529:Isoflavones; C446245:sophoraisoflavone A; C446243:licoisoflavone A; D003300:Copper; C446244:licoisoflavone B; D010100:Oxygen