[Behavior of soluble L-selectin in HIV infected children].
L-selectin is an adhesion molecule that is responsible for the initial attachment of leukocytes to endothelium. After leukocyte activation L-selectin is endoproteolytically released from the cell surface. In order to analyze the relationship between soluble L-selectin (sL-selectin) and parameters of immune activation and disease progression, 51 HIV infected children and 15 healthy controls were studied. Serum L-selectin concentrations were significantly higher in HIV infected children than in the control group. Levels of sL-selectin were higher in HIV infected patients with severe immunologic suppression than in those with moderate or no evidence of suppression. A positive correlation between sL-selectin levels and LTCD8 counts, sL-selectin and soluble intercellular adhesion molecule-1 (sICAM-1) and immunogobulin A (IgA) levels was detected. On the contrary sL-selectin concentration did not correlate with plasmatic viral load. The correlation with parameters of immune activation may implicate involvement of sL-selectin in the immunopathogenesis of HIV infection.
Gaddi
E
E
Departamento de Medicina, División Inmunología Clínica, Hospital General de Niños Dr. Pedro de Elizalde, Buenos Aires, Argentina.
Balbaryski
J
J
Cantisano
C
C
Barboni
G
G
Candi
M
M
Quiroz
H
H
Giraudi
V
V
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology / Q000378:metabolism; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000276:immunology / Q000378:metabolism; D019041:L-Selectin / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D008297:Male; D012995:Solubility; D019562:Viral Load
D007070:Immunoglobulin A; D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin