Interleukin-12 and interleukin-18 are indispensable for protective immunity against enteropathogenic Yersinia.
Previous results have demonstrated an essential role of gamma interferon (IFN-gamma) in resistance against Yersinia enterocolitica. Hence, we investigated the course of Yersinia infection in mice deficient for the IFN-gamma-inducing cytokines interleukin-12 (IL-12 p40(-/-)) or interleukin-18 (IL-18(-/-)). The experiments described herein argue for a critical role of both cytokines in protective immune responses against this pathogen.
Hein
J
J
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität, Pettenkoferstrasse 9a, München, D-80336, Germany. joachim.hein@mikrobio.med.uni-erlagen.de
Sing
A
A
Di Genaro
M S
MS
Autenrieth
I B
IB
D000818:Animals; D005260:Female; D007371:Interferon-gamma / Q000502:physiology; D018664:Interleukin-12 / Q000502:physiology*; D020382:Interleukin-18 / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica
D020382:Interleukin-18; D018664:Interleukin-12; D007371:Interferon-gamma