Severe haemolytic disease of the newborn due to anti-Js(b).
A case of anti-Js(b) in pregnancy was associated with unexpectedly severe haemolytic disease of the newborn, requiring urgent exchange transfusion. Clinical signs of fetal distress were evident at 35 weeks of gestation in a sixth pregnancy. A Js(b+) baby from a previous pregnancy had been unaffected. This case report illustrates the difficulties of predicting severity on the basis of anti-Js(b) titre, and highlights issues relating to the problems of using reconstituted frozen red cells from the rare red cell bank for exchange transfusion.
Stanworth
S
S
Reference Laboratory, Immunohaematology Department, North London Blood Centre, London, UK.
Fleetwood
P
P
de Silva
M
M
D000328:Adult; D004899:Erythroblastosis, Fetal / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D004921:Erythropoietin / Q000008:administration & dosage; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007626:Kell Blood-Group System / Q000009:adverse effects / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology; D011994:Recombinant Proteins
D007626:Kell Blood-Group System; D011994:Recombinant Proteins; D004921:Erythropoietin