Hypochlorite, oxidative modification of plasma lipoproteins, and atherosclerosis.
Hypochlorite produced in vivo by activated neutrophils, monocytes, and macrophages modifies blood lipoproteins and intensifies free radical lipid peroxidation, which probably plays a key role in the early stages of atherosclerotic vascular damages.
Panasenko
O M
OM
Laboratory of Physicochemical Methods for Assays and Analyses, Department of Experimental Medicine, Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow. oleg_panasenko@yahoo.com
Sergienko
V I
VI
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood* / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D006997:Hypochlorous Acid / Q000378:metabolism*; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000097:blood*; D008954:Models, Biological; D008956:Models, Chemical; D009000:Monocytes / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*
D005609:Free Radicals; D008074:Lipoproteins; D006997:Hypochlorous Acid; D010100:Oxygen