Detection of HTLV-I proviral DNA in sarcoidosis.
'Sarcoidosis-lymphoma syndrome' is known as an association of sarcoidosis with malignant lymphoma. We report a 56-year-old woman with systemic sarcoidosis who was seropositive for antibody against human T cell lymphoma/leukemia virus type I (HTLV-I). This patient showed integration of HTLV-I proviral DNA within cutaneous sarcoid nodules, but not in peripheral blood mononuclear cells. Neither atypical lymphocytes nor a T cell receptor beta1 gene rearrangement were observed in peripheral blood mononuclear cells or in cutaneous nodules, indicating that the patient did not have a smouldering type of adult T cell lymphoma/leukemia. Detection of integration of HTLV-I proviral DNA in cutaneous sarcoid nodules could suggest that the sarcoid nodules might have been generated as a protective response to chronic stimuli of HTLV-I.
Yajima
A
A
Department of Dermatology, Kinki University School of Medicine, Osaka, Japan.
Kawada
A
A
Aragane
Y
Y
Tezuka
T
T
D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000175:diagnosis / Q000821:virology*; D008875:Middle Aged; D011533:Proviruses / Q000235:genetics* / Q000302:isolation & purification; D012507:Sarcoidosis / Q000150:complications / Q000473:pathology / Q000821:virology*; D012867:Skin / Q000473:pathology / Q000821:virology*; D016662:Virus Integration
D004279:DNA, Viral