title: Individual differences of cerebrovascular responses to gravitational stress--prediction of orthostatic intolerance.
abstract: This experiment was designed to investigate the individual differences in the cerebrovascular responses to orthostatic stress. Seven male volunteers were exposed to head-up tilt (HUT) at 60 degrees for 15 min and to lower body negative pressure (LBNP) at 30 mmHg for 25 min. We measured the flow velocity of the middle cerebral artery and the quantity of the oxygenated and deoxygenated hemoglobin (oxy-Hb and deoxy-Hb) in the brain. Based upon oxy-Hb change during exposure to HUT, we classified the subjects into two groups: 1) the "good responder" group in which the oxy-Hb gradually increased from the 5th to 10th minute of HUT; 2) the "bad responder" group in which the oxy-Hb stabilized at lower levels after the initial decrease. The oxy-Hb changes between the two groups were significantly different during exposure to LBNP. During exposure to HUT and LBNP, no significant difference was observed in blood pressure and heart rate between the two groups. Our results suggest that there might be an individual difference in the cerebrovascular responses to orthostatic stress.
authors.affiliation: Department of Neurosurgery, Tokyo Metropolitan Police Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ueno
authors.forename: S
authors.initials: S
authors.lastname: Yoshimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Mayanagi
authors.forename: S
authors.initials: S
authors.lastname: Yumikura
authors.forename: C
authors.initials: C
authors.lastname: Sekiguchi
authors.forename: A
authors.initials: A
authors.lastname: Miyamoto
authors.forename: K
authors.initials: K
authors.lastname: Yajima
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004198:Disease Susceptibility; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology*; D008150:Lower Body Negative Pressure; D008297:Male; D011187:Posture / Q000502:physiology*; D011237:Predictive Value of Tests; D018667:Tilt-Table Test
chemical_list: D006454:Hemoglobins