title: All-night exposure to EMF does not alter urinary melatonin, 6-OHMS or immune measures in older men and women.
abstract: Healthy men (n = 22) and women (n = 24), 40-60 years of age, were exposed all-night (23:00-07:00 hr) to 60-Hz magnetic fields at an intensity (resultant flux density = 28.3 microTesla [microT]) well within the occupational-exposure range, or sham exposed under equivalent, counter-balanced, no-exposure ( < or = 0.2 microT) control conditions. Concentrations of melatonin, and the major metabolite of melatonin, 6-hydroxymelatonin-sulfate (6-OHMS), in first-void morning urine were not altered in either gender by exposure to the magnetic field, compared to control conditions. Statistical analysis also failed to reveal any evidence for exposure-related alterations in blood concentrations of multiple hematologic and immune system parameters (CD3, CD4, CD8, natural killer [NK] cells). The present results replicate and extend earlier negative findings based on the exposure of young men to power-frequency magnetic fields.
authors.affiliation: Midwest Research Institute, Kansas City, Missouri 64110, USA. cgraham@mriresearch.org
authors.forename: C
authors.initials: C
authors.lastname: Graham
authors.forename: A
authors.initials: A
authors.lastname: Sastre
authors.forename: M R
authors.initials: MR
authors.lastname: Cook
authors.forename: M M
authors.initials: MM
authors.lastname: Gerkovich
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine*; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: C054513:6-sulfatoxymelatonin; D008550:Melatonin