[Activity catalase and superoxide dismutase of Staphylococcus aureus during its persistence in the body].
The dynamics of the level of catalase and superoxidedismutase (SOD) expression by S. aureus isolated in persistent experimental kidney infection is described. A rise in the activity of the staphylococci under study during transition of the infectious process from the alteration to persistence stage. Changes in the expression of SOD and catalase were observed simultaneously with a decrease in hemolytic, fibrinolytic and protease activity, as well as in the presence of more pronounced clumping and an increase in the production of protein A, the antilysozyme and anticomplement activity of staphylococcal clones obtained from kidney tissue. The significance of all above-mentioned phenomena in the persistence of microorganisms is discussed.
Brudastov
Iu A
IuA
Research Institute of Cellular and Intracellular Symbiosis, Orenburg.
Sborets
T S
TS
Deriabin
D G
DG
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000201:enzymology* / Q000382:microbiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013203:Staphylococcal Infections / Q000201:enzymology*; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000302:isolation & purification; D013482:Superoxide Dismutase / Q000378:metabolism*
D002374:Catalase; D013482:Superoxide Dismutase