title: Synthesis and evaluation of alpha-LNA.
abstract: Three different synthetic routes to the alpha-configured LNA thymine monomer starting from D-allose or D-arabinose were investigated. The introduction of one or four alpha-LNA monomers into alpha-DNA had a destabilizing effect on the duplexes. However, a fully modified alpha-LNA sequence displayed strong recognition of complementary RNA, but no transition with DNA.
authors.affiliation: Department of Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.
authors.forename: N K
authors.initials: NK
authors.lastname: Christensen
authors.forename: J K
authors.initials: JK
authors.lastname: Dalskov
authors.forename: P
authors.initials: P
authors.lastname: Nielsen
mesh_terms: D001089:Arabinose / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D012313:RNA / Q000737:chemistry; D013941:Thymine / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D009841:Oligonucleotides; C002055:allose; D012313:RNA; D004247:DNA; D001089:Arabinose; D005947:Glucose; D013941:Thymine