Detection of a novel t(6;15)(q21;q21) in a pediatric Wilms tumor.
We report a novel cytogenetic finding in a favorable histology Wilms tumor occurring in a 4-month-old boy. Karyotypic analysis demonstrated a t(6;15)(q21;q21) in all tumor cells examined. This was confirmed using fluorescence in situ hybridization analysis. Molecular analysis of this rearrangement may provide clues to understanding the pathobiology of Wilms tumor.
Fernandez
C V
CV
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. conrad.fernandez@iwk.nshealth.ca
Lestou
V S
VS
Wildish
J
J
Lee
C L
CL
Sorensen
P H
PH
D020223:Chromosome Painting; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008297:Male; D011003:Ploidies; D014178:Translocation, Genetic / Q000235:genetics*; D014407:Tumor Cells, Cultured; D044465:White People / Q000235:genetics; D009396:Wilms Tumor / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy