title: Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer.
abstract: OBJECTIVE
  To correlate FDG activity on PET with the expression of glucose transporter proteins Glut-1 and Glut-3 in patients with early stage non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Over a 5 year period, all patients with a PET scan and clinical stage I NSCLC underwent an immunohistochemical analysis of their tumor for Glut-1 and Glut-3 expression. The amount of FDG uptake in the primary lesion was measured by a standardized uptake ratio (SUR) and correlated with immunohistochemical results.
  
  
  RESULTS
  Seventy-three patients with a mean age of 66 years had clinical stage I disease. The final pathologic stage showed 64 patients with stage IA/B disease, eight with stage IIA disease, and one patient with pathologic stage IIIA (T1N2) disease. Glut-1 transporter expression was significantly higher than Glut-3 (P<0.0001), and although there was some association between the SUR and Glut-1 (P=0.085) and SUR and Glut-3 (P=0.074) expression, this did not reach statistical significance.
  
  
  CONCLUSIONS
  Glut-1 and Glut-3 transporter expression did not demonstrate a statistically significant correlation with FDG uptake in potentially resectable lung cancer. It appears that these transporters alone do not affect the variation in FDG activity in early stage NSCLC.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. marom001@mc.duke.edu
authors.forename: E M
authors.initials: EM
authors.lastname: Marom
authors.forename: T A
authors.initials: TA
authors.lastname: Aloia
authors.forename: M B
authors.initials: MB
authors.lastname: Moore
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: J E
authors.initials: JE
authors.lastname: Herndon
authors.forename: D H
authors.initials: DH
authors.lastname: Harpole
authors.forename: P C
authors.initials: PC
authors.lastname: Goodman
authors.forename: E F
authors.initials: EF
authors.lastname: Patz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3; D006801:Humans; D007124:Immunoenzyme Techniques; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009004:Monosaccharide Transport Proteins / Q000032:analysis* / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
chemical_list: D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3; D009004:Monosaccharide Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; C495677:SLC2A1 protein, human; C495687:SLC2A3 protein, human; D019788:Fluorodeoxyglucose F18