Phosphoramidites and oligonucleotides containing 7-deazapurines and pyrimidines carrying aminopropargyl side chains.
The synthesis of phosphoramidites containing 7-deazaguanine, 7-deazaadenine, uracil and cytosine carrying aminopropargyl chains is described. The corresponding oligonucleotides are stabilized in duplexes thermally as well as against degradation by exonucleases.
Seela
F
F
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
Ramzaeva
N
N
Leonard
P
P
Chen
Y
Y
Debelak
H
H
Feiling
E
E
Kröschel
R
R
Zulauf
M
M
Wenzel
T
T
Fröhlich
T
T
Kostrzewa
M
M
D009841:Oligonucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
D009841:Oligonucleotides; D009943:Organophosphorus Compounds; D011687:Purines; D011743:Pyrimidines; C434331:phosphoramidite