title: [Thymoma with primary osseous and pulmonary metastases. Case report and review of the literature].
abstract: Bone metastases can be the first symptom of a tumor. The case of a 65-year-old patient with a thymoma exhibiting primary metastases in the lung and bone is presented. Initially, a tumor was suspected because of an osteolytic destruction of the right proximal femur posing a high risk of fracture. Further diagnostic procedures detected a partially sclerosing mediastinal bulk and bilateral lung metastases. The histological investigation of the resected proximal femur and needle biopsy of the mediastinal bulk showed an extrathoracically metastasized polygonal cell thymoma. This metastasizing pattern is common in thymic carcinoma but very rare in thymoma. In addition to the case presentation, a review of the current literature on histological classification, therapy, and prognosis is given.
authors.affiliation: Klinik für Chirurgie und Chirurgische Onkologie, Universitätsklinikum Charité, Medizinische Fakultät, Humboldt-Universität, Robert-Rössle-Klinik am Max-Delbrück-Centrum für Molekulare Medizin, 13122 Berlin.
authors.forename: G
authors.initials: G
authors.lastname: Rotter
authors.forename: U
authors.initials: U
authors.lastname: Schneider
authors.forename: P U
authors.initials: PU
authors.lastname: Tunn
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008297:Male; D015201:Meta-Analysis as Topic; D011182:Postoperative Care; D011379:Prognosis; D011446:Prospective Studies; D013902:Radiography, Thoracic; D016032:Randomized Controlled Trials as Topic; D013945:Thymoma / Q000145:classification / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D013953:Thymus Neoplasms / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents