Relationship between apoptosis of brain cells and free radical scavenging ability in rats during acute intermittent hypoxia.
It has been found that plateau hypoxia could induce apoptosis in rats' brain, but the mechanism was not clear. In order to study it further, we utilized acute intermittent hypoxia model to investigate reduced gliutathione (GSH), oxidized gliutathione(GSSG), super-oxide dismutase (SOD) and programmed cell death (PCD) or apoptosis (AP) in rats' brain. The results showed that with the increase of hypoxic exposure duration, apoptotic cells increased, the ratio of GSH/GSSG and the activity of SOD dropped. Regression analysis showed that there was a negative power relationship between the number of apoptotic cells and the ratio of GSH/GSSG or between the number of apoptotic cells and the activity of SOD in a limited range. It was concluded that there would be an intrinsic relationship between apoptosis and free radical scavenging ability in the organ.
Jiang
L
L
Research Laboratories of Trauma Center 304th Hospital, Beijing, China.
Xie
Y
Y
Sun
X
X
Yin
Z
Z
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001273:Atmosphere Exposure Chambers; D001921:Brain / Q000166:cytology*; D016166:Free Radical Scavengers; D005978:Glutathione / Q000378:metabolism*; D019803:Glutathione Disulfide / Q000378:metabolism*; D000860:Hypoxia; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
D016166:Free Radical Scavengers; D013482:Superoxide Dismutase; D005978:Glutathione; D019803:Glutathione Disulfide