Adhesion events in angiogenesis.
Recent work from several laboratories indicates that the coordination of endothelial cell adhesion events with growth factor receptor inputs regulates endothelial cell responses during angiogenesis. Analyses of the signaling pathways downstream of integrins, cadherins and growth-factor receptors are providing an insight into the molecular basis of known anti-angiogenic strategies, as well as into the design of novel therapies.
Eliceiri
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BP
The Scripps Research Institute, IMM-24, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Cheresh
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DA
D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D015703:Antigens, CD / Q000502:physiology; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D039564:Integrin alphaV; D016023:Integrins / Q000502:physiology*; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D017978:Receptors, Growth Factor / Q000502:physiology
D020533:Angiogenesis Inhibitors; D015703:Antigens, CD; D039564:Integrin alphaV; D016023:Integrins; D017978:Receptors, Growth Factor