[Birbeck granules in epidermal Langerhans cells of elderly patients with decubital ulcers].
Birbeck granules (Bg), known also as Langerhans cell (L) granules are special organelles found in the L cells' cytoplasm, which serve as a marker for their identification. These organelles have been studied in epidermal L cells in elderly patients with pressure sores and were compared to those found in epidermal L cells of healthy volunteers who served as controls.


RESULTS
There was an increase of about 47% in the number of B granules in patients' L cells from sacral epidermis near lesion (p < 0.01) and an increase of about 68% of the number of B granules in patients' L cells from normal epidermis (p < 0.005) was found as compared to healthy control L cells. Part of the B granules in patients' L cells were of similar morphology to those of controls. They were found throughout the cytoplasm as simple rods or rackets. In addition, in patients' epidermis some irregularly shaped granules were observed, such as: racket structure common to two or more rod structures; rod shaped granules in direct continuity with mitochondria, and others with lysosomes. Moreover, B granules in continuity with the cell plasma membrane and groups of closely opposed rod shaped granules were observed. These two last shaped structures apparently reflected formative stages of B granules. It is suggested that an increase of the number of B granules indicated an active state of L cells in the epidermis of patients studied. It is not clear whether the morphologic alterations of B granules influence the L cell functions in antigen presentation. It is possible that they may be partly involved in infections which occur frequently in patients with decubital ulcers. It is also possible that the increase in the number of B granules and the altered structures found among them in patients' epidermis express a reaction of L cells to inflammation.
Kohn
D
D
Nof Hagefen Hospital, Haifa, Israel.
Kohn
S
S
Schiller
D
D
D000368:Aged; D003594:Cytoplasmic Granules / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D003668:Pressure Ulcer / Q000473:pathology*; D012016:Reference Values; D012867:Skin / Q000473:pathology* / Q000648:ultrastructure