Role of anticholinesterase mechanism in suppression of antibody formation during acute poisoning with organophosphorus compounds.
Experiments on Wistar rats showed that acute poisoning with organophosphorus compound dimethyl dichlorovinyl phosphate (0.5 LD(50)) was accompanied by two opposite effects: inhibition of acetylcholinesterase in T lymphocytes leading to suppression of thymus-dependent antibody formation (predominant effect) and acetylcholine-induced stimulation of antibody production. Acetylcholine activated acetylcholinesterase in intact T cells.
Zabrodskii
P F
PF
Saratov State Medical University.
Kirichuk
V F
VF
Germanchuk
V G
VG
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D006801:Humans; D062025:Organophosphate Poisoning; D011041:Poisoning / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000201:enzymology / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D000109:Acetylcholine