Signatures of the immune response.
A compendium of global gene expression measurements from DNA microarray analysis of immune cells identifies gene expression signatures defining various lineages, differentiation stages, and signaling pathways. Germinal center (GC) B cells represent a discrete stage of differentiation with a unique gene expression signature. This includes genes involved in proliferation, as evidenced by high expression of G2/M phase regulators and low expression of ribosomal and metabolic genes that are transcriptional targets of c-myc. GC B cells also lack expression of the NF-kappaB signature genes, which may favor apoptosis. Finally, the transcriptional repression signature of BCL-6 reveals how this factor can prevent terminal differentiation of B cells and cause B cell lymphomas.
Shaffer
A L
AL
Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N114, Bethesda, MD 20892, USA.
Rosenwald
A
A
Hurt
E M
EM
Giltnane
J M
JM
Lam
L T
LT
Pickeral
O K
OK
Staudt
L M
LM
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D020013:Calcium Signaling; D019070:Cell Lineage; D006801:Humans; D008213:Lymphocyte Activation; D016328:NF-kappa B / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000737:chemistry; D013601:T-Lymphocytes / Q000502:physiology*
D016328:NF-kappa B; D012333:RNA, Messenger