Influence of cis-[Re2GABA2Cl4]Cl2 on the antioxidant defense system parameters of normal human blood.
The effect of the rhenium complex cis-[Re2GABA2Cl4]Cl2 on the antioxidant parameters of normal human blood in vitro have been studied. The results suggest that the complex influences various enzymes in the cascade of reactions utilizing active oxygen metabolites. However, the manifestation of this activity varies over the studied concentration range of the complex in the preincubation medium (10(-12)-10(-4) M), so the effects appear to be concentration-dependent. The largest differences in antioxidant parameters in comparison with control were observed for the concentrations 10(-8), 10(-5), and 10(-4) M. Thus, correlations between the peroxidation level, superoxide dismutase (SOD) activity, antioxidant factor (F), and indexes of resistance of erythrocytes for hemolysis (TR) were found.
Pirozhkova-Patalah
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IV
Department of Biophysics and Biochemistry, Dniepropetrovsk National University, Dniepropetrovsk, 49050, Ukraine. ppirina@aport.ru
Shtemenko
N I
NI
D000328:Adult; D000613:Aminobutyrates / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000032:analysis; D002374:Catalase / Q000097:blood / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood / Q000187:drug effects*
C439103:(rhenium(2)-gamma-aminobutyric acid(2)2chloride(4))chloride2; D000613:Aminobutyrates; D000975:Antioxidants; D009942:Organometallic Compounds; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase