title: Genomic imprinting of two antagonistic loci.
abstract: We present a model that considers the coevolution of genomic imprinting at a growth factor locus and an antagonistic growth suppressor locus. With respect to the two loci considered independently, our model makes the familiar predictions that an imprinted growth factor locus will only be expressed from the paternally derived allele and an imprinted growth suppressor locus only from the maternally derived allele. In addition, our coevolutionary model allows us to make predictions regarding the sequence of evolutionary events necessary for generating such a system. We conclude that imprinting at the growth factor locus preceded the evolution of growth suppressor function at the second locus, which in turn preceded imprinting at that locus. We then discuss the consistency of these predictions with currently available comparative data on the insulin-like growth factor 2 insulin-like growth factor 2 receptor system of mammals.
authors.affiliation: Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. jfwilkin@fas.harvard.edu
authors.forename: J F
authors.initials: JF
authors.lastname: Wilkins
authors.forename: D
authors.initials: D
authors.lastname: Haig
mesh_terms: D000818:Animals; D018392:Genomic Imprinting; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008957:Models, Genetic; D017527:Receptor, IGF Type 2 / Q000235:genetics*
chemical_list: D017527:Receptor, IGF Type 2; D007335:Insulin-Like Growth Factor II