title: Fiber size and myosin phenotypes of selected rhesus lower limb muscles after a 14-day spaceflight.
abstract: Muscle biopsies were taken from the rhesus (Macaca mulatta) soleus (Sol, a slow ankle extensor), medial gastrocnemius (MG, a fast ankle extensor), tibialis anterior (TA, a fast ankle flexor), and vastus lateralis (VL, a fast knee extensor) muscles in vivarium controls (n=5) before and after either a 14-day spaceflight (Bion 11, n=2) or a 14-day ground-based flight simulation (n=3). Myosin heavy chain (MHC) composition (gel electrophoresis), fiber type distribution (immunohistochemistry), and fiber size were determined. Although there were no significant changes, each muscle showed trends towards adaptation.
authors.affiliation: Brain Research Institute, University of California, Los Angeles, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Roy
authors.forename: H
authors.initials: H
authors.lastname: Zhong
authors.forename: S C
authors.initials: SC
authors.lastname: Bodine
authors.forename: D J
authors.initials: DJ
authors.lastname: Pierotti
authors.forename: R J
authors.initials: RJ
authors.lastname: Talmadge
authors.forename: G
authors.initials: G
authors.lastname: Barkhoudarian
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: J W
authors.initials: JW
authors.lastname: Fanton
authors.forename: I B
authors.initials: IB
authors.lastname: Kozlovskaya
authors.forename: V R
authors.initials: VR
authors.lastname: Edgerton
mesh_terms: D000818:Animals; D008253:Macaca mulatta; D008297:Male; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism / Q000473:pathology; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D009133:Muscular Atrophy / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D018995:Myosin Heavy Chains / Q000378:metabolism*; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*
chemical_list: D018995:Myosin Heavy Chains