How to MEK muscle.
Myogenesis is inhibited by receptor activation of Ras through the MEK and ERK kinases, but the underlying mechanism is unclear. In this issue of Molecular Cell, Perry et al. show that activated MEK1 forms an inhibitory complex with myogenic transcription factors in the nucleus.
Penn
B H
BH
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Berkes
C A
CA
Bergstrom
D A
DA
Tapscott
S J
SJ
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D048369:MAP Kinase Kinase 1; D020935:MAP Kinase Signaling System; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism*; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D017570:MyoD Protein / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D017570:MyoD Protein; D014157:Transcription Factors; D017346:Protein Serine-Threonine Kinases; D048369:MAP Kinase Kinase 1; D020929:Mitogen-Activated Protein Kinase Kinases