title: The effect of space radiation of the nervous system.
abstract: The long-term effects of irradiation by accelerated heavy ions on the structure and function of the nervous system have not been studied extensively. Although the adult brain is relatively resistant to low LET radiation, cellular studies indicate that individual heavy ions can produce serious membrane lesions and multiple chromatin breaks. Capillary hemorrhages may follow high LET particle irradiation of the developing brain as high RBE effects. Evidence has been accumulating that the glial system and blood-brain barrier (BBB) are relatively sensitive to injury by ionizing radiation. While DNA repair is active in neural systems, it may be assumed that a significant portion of this molecular process is misrepair. Since the expression of cell lethality usually requires cell division, and nerve cells have an extremely low rate of division, it is possible that some of the characteristic changes of premature aging may represent a delayed effect of chromatin misrepair in brain. Altered microcirculation, decreased local metabolism, entanglement and reduction in synaptic density, premature loss of neurons, myelin degeneration, and glial proliferation are late signs of such injuries. HZE particles are very efficient in producing carcinogenic cell transformation, reaching a peak for iron particles. The promotion of viral transformation is also efficient up to an energy transfer of approximately 300 keV/micron. The RBE for carcinogenesis in nerve tissues remains unknown. On the basis of available information concerning HZE particle flux in interplanetary space, only general estimates of the magnitude of the effects of long-term spaceflight on some nervous system parameters may be constructed.
authors.affiliation: Department of Neurological Surgery, University of California, San Francisco 94143, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Gauger
authors.forename: C A
authors.initials: CA
authors.lastname: Tobias
authors.forename: T
authors.initials: T
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Whitney
mesh_terms: D000016:Abnormalities, Radiation-Induced; D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects; D001921:Brain / Q000098:blood supply / Q000528:radiation effects*; D002196:Capillaries / Q000528:radiation effects; D016923:Cell Death; D002462:Cell Membrane / Q000528:radiation effects; D003359:Cosmic Radiation; D005314:Embryonic and Fetal Development / Q000528:radiation effects; D005123:Eye / Q000528:radiation effects; D020450:Heavy Ions; D006801:Humans; D009474:Neurons / Q000528:radiation effects*; D014796:Visual Perception