[The contribution of antioxidant enzymes in the cardioprotective effect of opioids during oxidative stress].
Intravenous administration of peptide delta 2-opioid receptor agonists increased cardiac sarcolemma resistance to subsequent oxidative stress in the isolated perfused rat heart in vitro. delta-Opioid receptor stimulation prevented oxidative stress-induced accumulation of lipid peroxides in myocardium and inhibition of superoxide dismutase. The cardioprotective and "antioxidant" effects of delta-agonists were completely abolished by in vivo pretreatment with the delta-receptor antagonist ICI 174,864. mu-Opioid receptor activation in vivo did not protect the isolated myocardium from cardiotoxic action of activated oxygen species.
Rebrova
T Iu
TIu
Institute of Cardiology, Kyevskay str. 111, 634050 Tomsk, Russia.
Maslov
L N
LN
Tam
S W
SW
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology; D015227:Lipid Peroxidation; D015428:Myocardial Reperfusion Injury / Q000201:enzymology* / Q000517:prevention & control; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*
D000701:Analgesics, Opioid; D000975:Antioxidants; D017465:Receptors, Opioid, delta; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D002374:Catalase; D013482:Superoxide Dismutase