Core binding factor and its role in normal hematopoietic development.
The core binding factors are a small family of transcription factors comprising a DNA binding CBFalpha subunit and a non-DNA binding CBFbeta subunit. One gene encoding a CBFalpha subunit, RUNX1 (also known as AML1, CBFA2, and PEBPA2A), and the gene encoding CBFbeta (CBFB) are essential for hematopoiesis and are frequently mutated in human leukemias. Both genes are required for the generation of hematopoietic stem cells (HSCs) during embryonic development. Expression studies in fish and frogs and functional analyses in flies indicate that a role for these genes in hematopoiesis is evolutionarily conserved.
Speck
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Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. Nancy.Speck@dartmouth.edu
D000818:Animals; D050676:Core Binding Factor Alpha 2 Subunit; D050658:Core Binding Factor beta Subunit; D004268:DNA-Binding Proteins / Q000502:physiology*; D004330:Drosophila / Q000196:embryology; D029721:Drosophila Proteins; D006410:Hematopoiesis; D006413:Hematopoietic System / Q000196:embryology*; D051379:Mice; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D011518:Proto-Oncogene Proteins; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000502:physiology*; D014981:Xenopus / Q000196:embryology; D029867:Xenopus Proteins; D015027:Zebrafish / Q000196:embryology; D029961:Zebrafish Proteins
C493693:Cbfb protein, mouse; D050676:Core Binding Factor Alpha 2 Subunit; D050658:Core Binding Factor beta Subunit; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; C493726:Runx1 protein, mouse; C493674:TfAP-2 protein, Drosophila; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D029867:Xenopus Proteins; D029961:Zebrafish Proteins; C099964:lz protein, Drosophila; C493675:tfap2a protein, Xenopus; C493676:tfap2a protein, zebrafish