title: Blazing pathways through genetic mountains.
abstract: It is now widely accepted that high-throughput data sources will shed essential understanding on the inner workings of cellular and organism function. One key challenge is to distill the results of such experiments into an interpretable computational form that will be the basis of a predictive model. A predictive model represents the gold standard in understanding a biological system and will permit us to investigate the underlying cause of diseases and help us to develop therapeutics. Here I explore how discoveries can be based on high-throughput data sources and discuss how independent discoveries can be assembled into a comprehensive picture of cellular function.
authors.affiliation: Department of Computer Science, Massachusetts Institute of Technology, 200 Technology Square, Cambridge, MA 02139, USA. gifford@mit.edu
authors.forename: D K
authors.initials: DK
authors.lastname: Gifford
mesh_terms: D000818:Animals; D019295:Computational Biology; D003198:Computer Simulation; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D016678:Genome; D023281:Genomics; D006801:Humans; D008957:Models, Genetic; D017422:Sequence Analysis, DNA