The missing link between envelope formation and fusion in alphaviruses.
Recent structural analyses of the Semliki Forest virus envelope suggest that the spike subunit E1, which is responsible for virus membrane fusion, also maintains the organization of the spike protein shell that encompasses the enveloped virus. This gives E1 a unique opportunity to control membrane stability during the membrane fusion reaction. Here, we present a model for this control mechanism.
Garoff
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H
Karolinska Institute, Dept of Biosciences at Novum, S-141 57 Huddinge, Sweden. henrik.garoff@cbt.ki.se
Cheng
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RH
D002462:Cell Membrane / Q000378:metabolism; D046911:Macromolecular Substances; D008561:Membrane Fusion; D008954:Models, Biological; D012672:Semliki forest virus / Q000235:genetics / Q000502:physiology*; D014760:Viral Fusion Proteins / Q000235:genetics / Q000502:physiology*
D046911:Macromolecular Substances; D014760:Viral Fusion Proteins