Molecular genetics of Ca(2+) stores and intracellular Ca(2+) signalling.
An increasing number of studies based on recombinant cells and on mouse models that express an altered repertoire of some of the key components of the intracellular Ca(2+) release stores are becoming available as a result of molecular genetics techniques. Information from these studies, together with results from studies of human diseases caused by mutations in genes that encode proteins of the intracellular Ca(2+) stores, are providing a significant advancement in understanding the interactive nature of the molecular machinery that underlies intracellular Ca(2+) signalling and how the different components of the Ca(2+) stores contribute to the regulation of cellular functions.
Sorrentino
V
V
Molecular Medicine Section, Dept. of Neuroscience, University of Siena, via Aldo Moro 5, Siena 53100, Italy.
Rizzuto
R
R
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D017136:Ion Transport / Q000235:genetics*; D008967:Molecular Biology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
D002118:Calcium