title: Where is APC going?
abstract: Adenomatous polyposis coli (APC) protein has been thought to function as a tumor suppressor through its involvement in the Wnt/beta-catenin signaling pathway. However, its connections to the cytoskeleton and microtubules in particular are becoming apparent, and the discovery of these new functions for APC is leading to a reevaluation of its role not only in tumorigenesis, but also in normal physiology.
authors.affiliation: KAN Research Institute, Kyoto Research Park, Shimogyo-ku, Kyoto 600-8815, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mimori-Kiyosue
authors.forename: S
authors.initials: S
authors.lastname: Tsukita
mesh_terms: D025601:Adenomatous Polyposis Coli Protein; D000818:Animals; D002465:Cell Movement; D003110:Colonic Neoplasms / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D003598:Cytoskeletal Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007365:Intercellular Junctions / Q000737:chemistry / Q000502:physiology; D008870:Microtubules / Q000737:chemistry / Q000502:physiology; D008938:Mitosis; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology
chemical_list: D025601:Adenomatous Polyposis Coli Protein; D003598:Cytoskeletal Proteins; D009363:Neoplasm Proteins