Anoikis mechanisms.
Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.
Frisch
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SM
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. sfrisch@burnham-inst.org
Screaton
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RA
D048868:Adaptor Proteins, Signal Transducing; D023102:Anoikis; D002352:Carrier Proteins / Q000378:metabolism; D003599:Cytoskeleton / Q000502:physiology; D053200:Fas-Associated Death Domain Protein; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology*; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D053200:Fas-Associated Death Domain Protein; D006133:Growth Substances; D016023:Integrins; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; C505533:FADD protein, human