N-(9-(9-phenylfluorenyl))homoserine-derived cyclic sulfamidates: novel chiral educts for the synthesis of enantiopure gamma-substituted alpha-amino acids.
(4S)-tert-Butyl 2,2-dioxo-3-PhF-1,2,3-oxathiazainane-4-carboxylate reacted effectively with nitrogen, sulfur, and oxygen nucleophiles to provide enantiopure (>97% ee) gamma-substituted alpha-amino acids. Reaction: see text.
Atfani
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Département de chimie, Université de Montréal, C. P. 6128, Succursale Centre-ville, Montréal, Québec, Canada H3C 3J7.
Wei
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Lubell
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