Deacetylravidomycin M, a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp. WK-6326. I. Taxonomy, fermentation, isolation and biological activities.
Streptomyces sp. WK-6326, a soil isolate, was found to produce an inhibitor of interleukin (IL)-4 signal transduction. Two structurally related compounds, a novel one designated deacetylravidomycin M and the known deacetylravidomycin, were isolated from the culture broth by solvent extraction, silica gel column chromatography and HPLC. Deacetylravidomycin M inhibited IL-4-induced CD23 expression in U937 cells without any cytotoxic effect, whereas deacetylravidomycin showed no inhibitory activity.
Arai
M
M
The Kitasato Institute, Kitasato University, Tokyo, Japan.
Tomoda
H
H
Matsumoto
A
A
Takahashi
Y
Y
Woodruff
B H
BH
Ishiguro
N
N
Kobayashi
S
S
Omura
S
S
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005285:Fermentation; D006801:Humans; D015847:Interleukin-4 / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D017455:Receptors, IgE; D015398:Signal Transduction / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D020298:U937 Cells
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D017455:Receptors, IgE; C435068:deacetylravidomycin M; D015847:Interleukin-4; C049540:desacetylravidomycin