[Cytochrome P-450 content and activity of NADPH-cytochrome P-450 c-reductase in experimental subarachnoid hemorrhage].
The condition was studied of the brain monooxigenase system (MOS) in experimental subarachnoidal hemorrhage in rats. The results show that the above hemorrhage leads to a significant depression of activity of brain MOS enzymes (cytochrome P-450, NADPN-cytochrome C-reductase). Depression of activity of the enzymic system is manifest from day 1 and has a tendency toward reduction but at day 14 and 21 the indices are still below the control values. Under the exposure to phenobarbital the reduction of activity of the enzyme system in subarachnoidal hemorrhage gets accelerated, with normalization of the indices occurring by day 7 after the hemorrhage.
Makhkamov
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D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D009251:NADPH-Ferrihemoprotein Reductase / Q000032:analysis* / Q000378:metabolism*; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013345:Subarachnoid Hemorrhage / Q000201:enzymology*; D013997:Time Factors
D003577:Cytochrome P-450 Enzyme System; D009251:NADPH-Ferrihemoprotein Reductase; D010634:Phenobarbital