title: Clinical and biological heterogeneity in pseudohypoparathyroidism syndrome. Results of a multicenter study.
abstract: Pseudohypoparathyroidism (PHP) is a rare inherited syndrome frequently associated with Albright's hereditary osteodystrophy (AHO). We conducted a multicenter study including 71 PHP children and 77 relatives. Erythrocyte Gsalpha biological activity was measured in each patient (normal range 85-110%). 61 patients were classified into four subtypes based on clinical and endocrine data and Gsalpha activity: 45 PHP Ia, 8 PHP Ib, 2 PHP II, and 6 PHP Ic. PHP Ia had decreased Gsalpha (58 +/- 9%), PHP Ib patients had PTH resistance, no AHO and normal Gsalpha (96 +/- 9%), PHP Ic patients had PTH resistance, AHO and no decreased Gsalpha (97 +/- 13%). The 10 remaining patients were considered to have pseudo-pseudohypoparathyroid (Pseudo-PHP) and were divided into two subtypes. One subtype had decreased Gsalpha and the second subtype had normal Gsalpha activity. The heterogeneous expression of Pseudo-PHP and thyrotropin resistance, which preceded parathyroid hormone resistance in 24% of the children, suggested that PHP might be a gradually evolving disease. GRF resistance was found in 4 out of 9 children investigated. The pedigree analysis showed PHP Ia had a dominant mode of inheritance with increased severity through generations. Pedigree analysis did not support a genomic imprinting hypothesis. Two children out of 9 had a chromosome 2 abnormality. This study confirms that Gsalpha activity is a significant marker in the diagnosis and classification of PHP.
authors.affiliation: Developmental Biology Unit, Faculty of Medicine, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Marguet
authors.forename: E
authors.initials: E
authors.lastname: Mallet
authors.forename: J P
authors.initials: JP
authors.lastname: Basuyau
authors.forename: D
authors.initials: D
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Leroy
authors.forename: P
authors.initials: P
authors.lastname: Brunelle
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D018740:Genetic Heterogeneity; D020962:Heterotrimeric GTP-Binding Proteins / Q000097:blood*; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D011547:Pseudohypoparathyroidism / Q000097:blood* / Q000145:classification / Q000175:diagnosis / Q000235:genetics*
chemical_list: D020962:Heterotrimeric GTP-Binding Proteins