title: Actinomyces naeslundii fimbrial protein Orf977 shows similarity to a streptococcal adhesin.
abstract: The nucleotide sequence of the chromosomal DNA, upstream of Actinomyces naeslundii T14V fimbrial gene fimA, was determined. One open reading frame (orf977) encoding 977 amino acids was found, preceded by a gene homologous to elongation factor TU. Database searches revealed that Orf977 was homologous to CshA, a Streptococcus gordonii protein involved in cell adhesion. Previous studies had already determined two genes in the type 2 fimbrial gene cluster of A. naeslundii T14V: the structural subunit fimA, and orf365 with unknown function, followed by ribosomal genes. This study completes the type 2 fimbrial gene cluster sequence.
authors.affiliation: Department of Pediatric Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: L
authors.initials: L
authors.lastname: Hoflack
authors.forename: M K
authors.initials: MK
authors.lastname: Yeung
mesh_terms: D000190:Actinomyces / Q000235:genetics*; D018829:Adhesins, Bacterial / Q000737:chemistry / Q000235:genetics*; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D010861:Fimbriae, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics*; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017386:Sequence Homology, Amino Acid; D013298:Streptococcus sanguis / Q000235:genetics
chemical_list: D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; C079041:CshA protein, Streptococcus gordonii; D008565:Membrane Proteins; C440222:Orf977 Protein, Actinomyces