title: New developments in long-term treatment of HIV: the honeymoon is over.
abstract: New recommendations advise starting highly active antiretroviral therapy (HAART) slightly later in the course of HIV disease compared with earlier guidelines. HAART has prolonged life in HIV patients, altering the spectrum of problems being treated. As the immune system recovers, long-term prophylaxis against some secondary infections can be discontinued. The problem, however, is that HAART also has serious long-term side effects such as lactic acidosis, lipodystrophy, and the promotion of drug-resistant strains of HIV.
authors.affiliation: Department of Infectious Diseases, Cleveland Clinic Foundation, OH 44195, USA. isadac@ccf.org
authors.forename: C M
authors.initials: CM
authors.lastname: Isada
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects / Q000639:trends*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008134:Long-Term Care; D013997:Time Factors
chemical_list: D019380:Anti-HIV Agents