Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae.
Propagation of Saccharomyces cerevisiae cells in conjugated linoleic acid (CLA) medium resulted in activation of the transcriptional machinery that responds to fatty acids. Cells utilized efficiently trans-10,cis-12 CLA, but not the corresponding cis-9,trans-11 isomer, probably due to the formation of cis-3,trans-5-dienoyl-CoA intermediates that are recalcitrant to beta-oxidation.
Gurvitz
A
A
Institut für Biochemie und Molekulare Zellbiologie der Universität Wien and Ludwig Boltzmann-Forschungsstelle für Biochemie, Vienna, Austria. ag@abc.univie.ac.at
Hamilton
B
B
Ruis
H
H
Hartig
A
A
Hiltunen
J K
JK
D019748:Carbon-Carbon Double Bond Isomerases / Q000378:metabolism; D019787:Linoleic Acid / Q000737:chemistry / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D013237:Stereoisomerism
D019787:Linoleic Acid; D019748:Carbon-Carbon Double Bond Isomerases; C085575:delta(3,5),delta(2,4)-dienoyl-CoA isomerase