title: High-performance liquid chromatographic enantioseparation of beta-amino acids.
abstract: Direct and indirect high-performance liquid chromatographic methods were developed for the enantioseparation of beta-amino acids (beta-substituted-beta-alanines). Direct separation involved the application of chiral columns: Crownpak CR(+), Chirobiotic T and Chirobiotic R. Indirect separation was based on precolumn derivatization with 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate or N-alpha-(2,4-dinitro-5-fluorophenyl)-L-alanineamide (Marfey's reagent), with subsequent separation on an achiral column. The chromatographic conditions were varied to achieve optimum separation.
authors.affiliation: Department of Inorganic and Analytical Chemistry, University of Szeged, Hungary. apeter@chem.u-szeged.hu
authors.forename: A
authors.initials: A
authors.lastname: Péter
authors.forename: L
authors.initials: L
authors.lastname: Lázár
authors.forename: F
authors.initials: F
authors.lastname: Fülöp
authors.forename: D W
authors.initials: DW
authors.lastname: Armstron
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids