title: Radiation quality and risk estimation in relation to space missions.
abstract: While Q is specified as a function of linear energy transfer (LET) in practice the Q for neutrons has been selected by a judgment decision based on the relative biological effectiveness (RBE) to induce stochastic effects.  There are no RBE values for tumor induction by heavy ions or protons in humans.  Thus, selection of Q values has been based either on LET (or lineal energy) or RBEs from animal experiments.  Estimates of Q for heavy ions in low earth orbit (LEO) range from about 5 to 14.  The average Q value of all radiation in LEO has been estimated to be about 1.3.  There is a lack of experimental data for RBEs for heavy ions but RBE increases as a function of LET.  In the case of the Harderian gland the RBE reaches a maximum of 25-30 between about 100-200 keV/micrometer but does not appear to decrease at higher LETs.  The International Commission of Radiological Protection have proposed the use of radiation weighting factors in lieu of quality factors.  The weighting factors will range from 1 to 20.
authors.affiliation: Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Fry
mesh_terms: D000818:Animals; D003359:Cosmic Radiation / Q000009:adverse effects*; D004307:Dose-Response Relationship, Radiation; D004601:Elementary Particles; D005260:Female; D006801:Humans; D015994:Incidence; D018499:Linear Energy Transfer; D051379:Mice; D008807:Mice, Inbred BALB C; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D011829:Radiation Dosage; D011835:Radiation Protection / Q000592:standards*; D011839:Radiation, Ionizing; D011853:Radiobiology / Q000379:methods*; D051381:Rats; D012062:Relative Biological Effectiveness; D018570:Risk Assessment; D013026:Space Flight; D013269:Stochastic Processes