1,2-disubstituted cyclohexane carbocyclic analogues of nucleosides.
Several compounds of a new series of cyclohexane-based 1,2-disubstituted carbonucleoside analogues, were synthesized. The adenine and uridine derivatives, were prepared by construction of the heterocyclic base on the primary amino group of 2-aminocyclohexylmethanol, and the thymine derivative by condensation of 2-hydroxycyclohexylmethanol with thymine using the Mitsunobu reaction.
Viña
D
D
Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
Santana
L
L
Uriarte
E
E
D000225:Adenine / Q000031:analogs & derivatives; D003510:Cyclohexanes / Q000138:chemical synthesis*; D009705:Nucleosides / Q000138:chemical synthesis*; D013941:Thymine / Q000031:analogs & derivatives; D014529:Uridine / Q000031:analogs & derivatives
D003510:Cyclohexanes; D009705:Nucleosides; D000225:Adenine; D013941:Thymine; D014529:Uridine