title: The synthesis of, and studies on, 2'-C-modified nucleotides.
abstract: The synthesis of uridine monomers containing either a 2'-deoxy-2'-C-methylcyano or ethylcyano group is described. These monomers are intended for incorporation into oligonucleotides to investigate a proposed duplex-stabilising effect exerted by 2'-tethered amide groups.
authors.affiliation: Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom.
authors.forename: L
authors.initials: L
authors.lastname: Brennan
authors.forename: K J
authors.initials: KJ
authors.lastname: Fettes
authors.forename: I A
authors.initials: IA
authors.lastname: O'Neil
authors.forename: R
authors.initials: R
authors.lastname: Cosstick
mesh_terms: D011742:Pyrimidine Nucleotides / Q000138:chemical synthesis*; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D011742:Pyrimidine Nucleotides; D014529:Uridine