MTHFR 677 C-->T mutation: a predictor of early-onset coronary artery disease risk.
The atherosclerotic potential of the methyenetetrahydrofolate reductase (MTHFR) gene mutation 677 C --> T substitution remains controversial. In this study, we describe the association of this mutation in a Southern Texan patient population of multiracial ethnic background with risk and extent of coronary artery disease (CAD) as measured by luminal narrowing. Sixty nine patients who were 50 years or younger composed our population. Chi-square analysis was used to analyze the data and found a significant association between CAD and this mutation (P value=0.03). In addition, in the small number of patients in this study who had diabetes, those who had mutation have more severe disease than those without the mutation. This study highlights the potential cardiovascular prognostic significance of the MTHFR 677 C --> T in the studied population.
Payne
D A
DA
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0743, USA. dpayne@utmb.edu
Chamoun
A J
AJ
Seifert
S L
SL
Stouffer
G A
GA
D000328:Adult; D017668:Age of Onset; D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D008875:Middle Aged; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D010865:Pilot Projects; D011379:Prognosis; D012307:Risk Factors; D013781:Texas / Q000453:epidemiology
D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)