[Effect of benzonal on the absorptive-secretory function in the liver of immature rabbits in post-compression period of long-term compression syndrome].
The absorptive-secretory function of hepatocytes using chromodiagnostic test by means of cardiogrin in rabbits at the age of 1 month in postcompression period of prolonged compression syndrome (PCS) was studied. It was established that the given function of hepatocytes was sufficiently and stably depressed for PCS. By effect of inductor of hepatocytes' monooxygenase system benzonal the disorders in parameters of cardiogreen pharmacokinetics are being distinctly removed. The velocity of blood stream in the liver was restored up to a level in health animals. It is supposed that an inclusion of benzonal into a complex of therapeutical remedies allows to enhance an effectiveness in PCS treatment during prepubescent period.
Rakhmatullaev
F Kh
FKh
Central Research Laboratory, Second State Medical Institute, ul. Farobi, 2, Tashkent, 700109 Uzbekistan.
Khakimov
Z Z
ZZ
D000042:Absorption; D000367:Age Factors; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D004396:Coloring Agents; D003444:Crush Syndrome / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D011817:Rabbits
D001463:Barbiturates; D004396:Coloring Agents; D007208:Indocyanine Green; C002915:benzobarbital