The quantitative 19F-imaging of albumin at 1.5 T: a potential in-vivo tool.
19F-MR-imaging has been used to quantitate albumin concentration in a phantom at 1.5 T. The experimentally derived relationship between albumin concentration and the T1 relaxation time of a fluorinated marker, tetrafluorosuccinic acid (TFSA) was used to calculate the albumin concentration from a quantitative 19F T1 map acquired using a gradient echo sequence. There was close correlation between calculated and actual BSA concentrations (r = 0.99, SE = 0.15). The potentially interfering effect of paramagnetic species on T1 relaxation times was also investigated. Relaxivity data show that albumin concentration measurements should be performed prior to any contrast agent administration.
Dzik-Jurasz
A S
AS
The CRC Clinical Magnetic Resonance Research Group, SM2 5PT, Sutton, UK. andrej@icr.ac.uk
Wolber
J
J
Prock
T
T
Collins
D J
DJ
Leach
M O
MO
Rowland
I J
IJ
D000418:Albumins / Q000032:analysis*; D000963:Antimetabolites; D005461:Fluorine; D005466:Fluorocarbons; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D012709:Serum Albumin / Q000032:analysis; D013386:Succinates
D000418:Albumins; D000963:Antimetabolites; D005466:Fluorocarbons; D012709:Serum Albumin; D013386:Succinates; D005461:Fluorine; C060763:perfluorosuccinic acid