[Endogenous neuropeptides and regulation of the brain functional plasticity].
This review analysed the data about the neuropeptides secreted from the different brain structures. Involvement of the endogenous neuropeptides in synaptic plasticity was tested at the model of long-term potentiation (LTP) as a form of learning and the memory formation. The most of these neuropeptides or their fragments involves in the induction and maintenance of the LTP and provides the transformation of short-term excitability of the neurones into the long-term one. They may be considered as nootropic compounds. It is proposed that the system of peptidergic regulation of neuronal plasticity functionates in the brain and there are a possibility to correct the activity of this system during the different pathology.
Mokrushin
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Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Pavlinova
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D000818:Animals; D001921:Brain / Q000502:physiology*; D007858:Learning / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D008568:Memory / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology*; D018847:Opioid Peptides / Q000502:physiology; D018079:Receptors, GABA / Q000502:physiology
D009414:Nerve Growth Factors; D009479:Neuropeptides; D018847:Opioid Peptides; D018079:Receptors, GABA