title: Signatures of the immune response.
abstract: A compendium of global gene expression measurements from DNA microarray analysis of immune cells identifies gene expression signatures defining various lineages, differentiation stages, and signaling pathways. Germinal center (GC) B cells represent a discrete stage of differentiation with a unique gene expression signature. This includes genes involved in proliferation, as evidenced by high expression of G2/M phase regulators and low expression of ribosomal and metabolic genes that are transcriptional targets of c-myc. GC B cells also lack expression of the NF-kappaB signature genes, which may favor apoptosis. Finally, the transcriptional repression signature of BCL-6 reveals how this factor can prevent terminal differentiation of B cells and cause B cell lymphomas.
authors.affiliation: Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 4N114, Bethesda, MD 20892, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Shaffer
authors.forename: A
authors.initials: A
authors.lastname: Rosenwald
authors.forename: E M
authors.initials: EM
authors.lastname: Hurt
authors.forename: J M
authors.initials: JM
authors.lastname: Giltnane
authors.forename: L T
authors.initials: LT
authors.lastname: Lam
authors.forename: O K
authors.initials: OK
authors.lastname: Pickeral
authors.forename: L M
authors.initials: LM
authors.lastname: Staudt
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D020013:Calcium Signaling; D019070:Cell Lineage; D006801:Humans; D008213:Lymphocyte Activation; D016328:NF-kappa B / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000737:chemistry; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D016328:NF-kappa B; D012333:RNA, Messenger