title: Alpha-oligonucleotides with anionic phosphodiester and cationic phosphoramidate linkages enhanced stability of DNA triple helix.
abstract: Synthesis of several alpha-oligonucleotides containing both anionic phosphodiester and cationic N-(dimethylaminopropyl)phosphoramidate internucleosidic linkages is described. Their ability to form triple helix with dsDNA was evaluated at various pH by UV melting experiments.
authors.affiliation: Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, CC 008, Université Montpellier II, Place Eugène Bataillon, 34095 Montpellier, France.
authors.forename: F
authors.initials: F
authors.lastname: Ehrenmann
authors.forename: J J
authors.initials: JJ
authors.lastname: Vasseur
authors.forename: F
authors.initials: F
authors.lastname: Debart
mesh_terms: D000577:Amides / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry*
chemical_list: D000577:Amides; D003432:Cross-Linking Reagents; D009841:Oligonucleotides; D010756:Phosphoric Acids; D004247:DNA; C011067:phosphoramidic acid