title: Microgravity and musculoskeletal system of mammals.
abstract: This review surveys data in the literature and our own findings concerning the effects of weightlessness on bones and muscles of white rats flown on Cosmos biosatellites and Spacelab-3.  It has been shown that the magnitude and sign of functional changes in muscles depend on their biomechanical profile.  Structural and metabolic foundations of functional adaptation and its dynamics have been identified:  in 5-7 day flights muscle contractility changes are mainly associated with a diminished activity of excitation-contraction coupling, in longer-term flights they are produced by changes in myosin populations specific for myofibers of different functional profile.  At early flight stages (up to 1 week) osteoporosis and bone demineralization are very mild; therefore decrease in bone mechanical strength may be caused by changes in physico-chemical parameters of the collagen-crystal system.  In flights of up to 3 weeks noticeable osteoporosis develops which is primarily produced by osteogenesis inhibition and which is responsible for a marked decrease of bone strength.  These changes may result from uncoupling of bone resorption and remodelling processes.  This uncoupling is characterized as incomplete osteogenesis and may be caused by changes in the collagen composition of the organic bone matrix.  The above-mentioned adaptive changes in muscle functions of specific skeletal compartments may play a role in different responses of various bones to weightlessness.
authors.affiliation: Institute of Biomedical Problems, USSR Ministry of Health, Moscow.
authors.forename: E A
authors.initials: EA
authors.lastname: Ilyin
authors.forename: V S
authors.initials: VS
authors.lastname: Oganov
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D018488:Bone Demineralization, Pathologic / Q000503:physiopathology; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D009133:Muscular Atrophy / Q000503:physiopathology; D009142:Musculoskeletal Physiological Phenomena; D009218:Myosins / Q000032:analysis; D010012:Osteogenesis / Q000502:physiology; D051381:Rats; D013026:Space Flight; D014893:Weightlessness
chemical_list: D009218:Myosins