title: Changing epidemiological features of subacute sclerosing panencephalitis.
abstract: BACKGROUND
  Subacute sclerosing panencephalitis (SSPE) is a chronic central nervous (CNS) system infection caused by measles virus. Because changing immunization practices affect the epidemiology of measles and consequently SSPE, we examined the epidemiological data of our SSPE registry.
  
  
  METHODS
  Age of onset, age at onset of measles, duration of Latent period and immunization status were examined in cases recorded at the SSPE Registry Center in Turkey between 1975 and 1999.
  
  
  RESULTS
  Age of onset diminished from 13 years before 1994 to 7.6 years after 1995; age at onset of measles declined from 29 months to 20 months and the Latent interval from 9.9 years to 5.9 years. Age at onset of measles and immunization status did not directly affect the duration of the Latent period.
  
  
  CONCLUSIONS
  Although its incidence has decreased in Turkey, SSPE has been seen at younger ages in recent years. This change cannot be attributed solely to younger age at onset of measles. Factors affecting the duration of the Latent period should be investigated further.
authors.affiliation: Hacettepe University Dept. of Pediatric Neurology, Ankara, Turkey. banlar@gen.hun.edu.tr
authors.forename: B
authors.initials: B
authors.lastname: Anlar
authors.forename: G
authors.initials: G
authors.lastname: Köse
authors.forename: Y
authors.initials: Y
authors.lastname: Gürer
authors.forename: S
authors.initials: S
authors.lastname: Altunbaşak
authors.forename: S
authors.initials: S
authors.lastname: Haspolat
authors.forename: M
authors.initials: M
authors.lastname: Okan
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008457:Measles / Q000150:complications* / Q000517:prevention & control; D008458:Measles Vaccine / Q000627:therapeutic use; D012307:Risk Factors; D013344:Subacute Sclerosing Panencephalitis / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D014421:Turkey / Q000453:epidemiology
chemical_list: D008458:Measles Vaccine