title: High-performance liquid chromatography-electrospray ionization mass spectrometry and multiple mass spectrometry studies of hyperforin degradation products.
abstract: The alcoholic extract of the aerial parts of Hypericum perforatum L. finds wide application because of its antidepressant activity. The extract contains a number of constituents with documented biological activity including chlorogenic acid, a broad range of flavonoids, naphthodianthrones and phloroglucinols. Hyperforin and adhyperforin are the major phloroglucinol constituents found in the lipophilic fraction of the extracts. Since the stability of hyperforin has been shown to be limited, an investigation of the hyperforin degradation products using HPLC-electrospray ionization mass spectrometry and multiple mass spectrometry was undertaken.
authors.affiliation: Indena SpA, Laborarori Ricerca e Sviluppo, Settala (Milan), Italy.
authors.forename: N
authors.initials: N
authors.lastname: Fuzzati
authors.forename: B
authors.initials: B
authors.lastname: Gabetta
authors.forename: I
authors.initials: I
authors.lastname: Strepponi
authors.forename: F
authors.initials: F
authors.lastname: Villa
mesh_terms: D001643:Bridged Bicyclo Compounds; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D020902:Hypericum / Q000737:chemistry*; D010696:Phloroglucinol / Q000031:analogs & derivatives; D010936:Plant Extracts / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013729:Terpenes / Q000737:chemistry*
chemical_list: D001643:Bridged Bicyclo Compounds; D010936:Plant Extracts; D013729:Terpenes; D010696:Phloroglucinol; C001654:hyperforin