title: Resorption of the temporomandibular condylar bone according to subtypes of juvenile chronic arthritis.
abstract: OBJECTIVE
  To evaluate the relative impact of sex, type of onset, course of disease, age at onset, duration of disease and status of HLA-B27, antinuclear antibodies (ANA), and rheumatoid factor on the risk of developing a condylar erosion.
  
  
  METHODS
  Condylar changes of the temporomandibular joint (TMJ) were diagnosed on orthopantomograms from 169 consecutive patients with juvenile chronic arthritis (JCA). A multiple regression analysis was applied to establish the relative weight of the independent variables affecting the severity of the condylar erosion.
  
  
  RESULTS
  It was found that 62.1% of the patients exhibited condylar resorption. The highest prevalence was seen in children with a polyarticular onset or course of disease and early age at onset and severe resorption was also frequent in these groups. Patients with positive ANA also had a high prevalence but with a mild degree of resorption. In contrast, HLA-B27 positive patients had a lower risk of TMJ involvement and resorptive changes of the condyle.
  
  
  CONCLUSIONS
  Polyarticular and early onset arthritis are associated with a high risk for TMJ involvement and a severe condylar bone loss can be expected. ANA positive patients have a high prevalence, and B27 positive patients have a low prevalence of TMJ arthritis but in both subgroups, the outcome of the bone resorptive process is mild.
authors.affiliation: Department of Orthodontics, Pediatric Rheumatology Clinic, Aarhus University Hospital, Denmark.
authors.forename: T K
authors.initials: TK
authors.lastname: Pedersen
authors.forename: J J
authors.initials: JJ
authors.lastname: Jensen
authors.forename: B
authors.initials: B
authors.lastname: Melsen
authors.forename: T
authors.initials: T
authors.lastname: Herlin
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001171:Arthritis, Juvenile / Q000150:complications* / Q000175:diagnosis; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008335:Mandibular Condyle / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015995:Prevalence; D011336:Probability; D011379:Prognosis; D011859:Radiography; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D013704:Temporomandibular Joint / Q000000981:diagnostic imaging / Q000503:physiopathology*