title: Dictyostelium discoideum, a lower eukaryote model for the study of DNA repair:  implications for the role of DNA-damaging chemicals in the evolution of repair proficient cells.
abstract: The evolution of the ability of living cells to cope with stress is crucial for the maintenance of their genetic integrity. Yet low levels of mutation must remain to allow adaptation to environmental changes. The cellular slime mold D. discoideum is a good system for studying molecular aspects of the repair of lethal and mutagenic damage to DNA by radiation and chemicals. The wild-type strains of this soil microorganism are extremely resistant to DNA damaging agents. In nature the amoeboid cells in their replicative stage feed on soil bacteria and are exposed to numerous DNA-damaging chemicals produced by various soil microorganisms. It is probable that the evolution of repair systems in this organism and perhaps in others is a consequence of the necessity to cope with chemical damage which also confers resistance to radiation.
authors.affiliation: Department of Molecular and Cell Biology, The Pennsylvania State University, University Park 16802, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Deering
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001761:Bleomycin / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects*; D004271:DNA, Fungal; D004023:Dictyostelium / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D016296:Mutagenesis; D009154:Mutation / Q000187:drug effects; D011836:Radiation Tolerance
chemical_list: D004271:DNA, Fungal; D001761:Bleomycin