title: SNF4435C and D, novel immunosuppressants produced by a strain of Streptomyces spectabilis. II. Structure elucidation.
abstract: SNF4435C and D are new immunosuppressants isolated from the culture broth of a strain of Streptomyces spectabilis. Their molecular formulas were determined as C28H31NO6 based on the HRFAB-MS analyses. The structures of SNF4435C and D were elucidated to be novel nitrophenyl pyrones having an intriguing tricyclic ring system and diastereoisomers of each other by spectroscopic analyses including various NMR measurements.
authors.affiliation: Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan. k-takahashi@snowbrand.co.jp
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: E
authors.initials: E
authors.lastname: Tsuda
authors.forename: K
authors.initials: K
authors.lastname: Kurosawa
mesh_terms: D005285:Fermentation; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009574:Nitro Compounds / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry*; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007166:Immunosuppressive Agents; D009574:Nitro Compounds; D011753:Pyrones; C435067:SNF 4435C; C435066:SNF 4435D