Phosphorylation of glyceric acid in aqueous solution using trimetaphosphate.
The phosphorylation of glyceric acid is an interesting prebiotic reaction because it converts a simple, potentially prebiotic organic molecule into phosphate derivatives that are central to carbohydrate metabolism. We find that 0.05 M glyceric acid in the presence of 0.5 M trimetaphosphate in alkaline solution gives a mixture of 2- and 3-phosphoglyceric acids in combined yields of up to 40%.
Kolb
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The Salk Institute for Biological Studies, San Diego, CA 92186-5800, USA.
Orgel
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D017666:Deuterium Oxide; D019418:Evolution, Chemical; D005988:Glyceric Acids / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D010766:Phosphorylation; D011122:Polyphosphates / Q000737:chemistry*; D013997:Time Factors
D005988:Glyceric Acids; D011122:Polyphosphates; C008885:2-phosphoglycerate; C042971:glyceric acid; C005156:3-phosphoglycerate; C009293:trimetaphosphoric acid; D017666:Deuterium Oxide