title: Lutropin receptor function: insights from natural, engineered, and computer-simulated mutations.
abstract: The lutropin receptor is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimer glycoprotein hormone family. As reviewed herein, comparative analyses of natural, engineered, and computer-simulated mutations of the lutropin receptor have provided considerable insight into the molecular basis of receptor function.
authors.affiliation: Department of Chemistry, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fanelli
authors.forename: A P
authors.initials: AP
authors.lastname: Themmen
authors.forename: D
authors.initials: D
authors.lastname: Puett
mesh_terms: D000595:Amino Acid Sequence; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008297:Male; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D015202:Protein Engineering; D017434:Protein Structure, Tertiary; D011974:Receptors, LH / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D011974:Receptors, LH