title: Review: what can structural classifications reveal about protein evolution?
abstract: In this article we present a review of the methods used for comparing and classifying protein structures. We discuss the hierarchies and populations of fold groups and evolutionary families in some of the major classifications and we consider some of the problems confronting any general analyses of structural evolution in protein families. We also review some more recent analyses that have expanded these classifications by identifying sequence relatives in the genomes and thereby reveal interesting trends in fold usage and recurrence.
authors.affiliation: Department of Biochemistry and Molecular Biology, University College, Gower Street, London, WC1E 6BT, United Kingdom.
authors.forename: C A
authors.initials: CA
authors.lastname: Orengo
authors.forename: I
authors.initials: I
authors.lastname: Sillitoe
authors.forename: G
authors.initials: G
authors.lastname: Reeves
authors.forename: F M
authors.initials: FM
authors.lastname: Pearl
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000145:classification* / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D011506:Proteins