[Estrogenic and contraceptive activity of 17-R-hydroximino derivatives of 9alpha-hydroxy-11beta-nitroxyestrones].
The estrogenic or uterotropic (UA) and contraceptive (CA) activity of two modified steroids representing 17-R-oximino-9 alpha-oxy-11 beta-nitroxyestrone derivatives (compounds I and II) was experimentally studied by oral administration in female rats in comparison to ethynylestradiol (EED) and mestranol. Compounds I and II showed significant UA (about half that of EED and mestranol) and a pronounced contraceptive effect (exceeding that of mestranol). The dissociation of the drug effects for CA is also indicated by the index of contraception (IC) or the CA/UA ratio. The administration of compounds I and II did not lead to a loss of animals in the acute toxicity tests on female mice.
Ivanenko
T I
TI
Laboratory for Biological Investigation of Hormonal Compounds, Endocrine Research Center, Russian Academy of Medical Sciences, ul. Dmitriya Ul'yanova 11, Moscow, 117036 Russia.
Pluzhnikova
G N
GN
Fedotov
V P
VP
D000818:Animals; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology* / Q000633:toxicity; D004970:Estrone / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D007097:Imines / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D051381:Rats; D023382:Toxicity Tests, Acute
D003280:Contraceptives, Oral, Synthetic; D007097:Imines; D004970:Estrone