title: Effects of 14-day spaceflight on myosin heavy chain expression in biceps and triceps muscles of the rhesus monkey.
abstract: In rats, changes in myosin expression are induced by the chronic elimination of weight-bearing activity, particularly in the postural muscles. This occurs during spaceflight and hindlimb suspension. Myosin heavy chain (MHC) changes affect fast and slow fiber types differently depending on muscle function. An increase in co-expression of different MHC within the same fiber will signal early changes in muscle fibers. In the rat soleus muscles, the spaceflight-induced increase in fast MHC expression appears to be essentially due to the enhanced or de novo synthesis of IID or IIX MHC. In response to microgravity, the expression of slow-type myosin decreases, while that of fast-type increases. There is scarce information concerning the effect of microgravity on rhesus monkeys (Macaca mulatta), especially on their upper limbs. We investigated the expression of MHC using an immunocytochemical approach to determine the nature and magnitude of the changes in biceps and triceps muscles of rhesus monkeys during the Bion 11 14-day mission.
authors.affiliation: CNRS, Faculte des Sciences, Nice, France.
authors.forename: A
authors.initials: A
authors.lastname: Chopard
authors.forename: L
authors.initials: L
authors.lastname: Leclerc
authors.forename: F
authors.initials: F
authors.lastname: Pons
authors.forename: J J
authors.initials: JJ
authors.lastname: Leger
authors.forename: J F
authors.initials: JF
authors.lastname: Marini
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D007150:Immunohistochemistry; D008253:Macaca mulatta; D008297:Male; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000378:metabolism*; D013026:Space Flight; D014893:Weightlessness
chemical_list: D018995:Myosin Heavy Chains