title: Terbinafine hydrochloride treatment of Microsporum canis experimentally-induced ringworm in cats.
abstract: Cats represent the most important source of Microsporum canis infection to people. Terbinafine hydrochloride is commonly used in the treatment of microsporosis. Its fungicidal action permits short period of treatment. It was our objective to evaluate the effectiveness of this drug in treatment of microsporosis in cats. We treated nine experimentally M. canis infected cats with terbinafine at a dose of 10-20mg/kg SID (low-dose group, LDG), nine cats with 30-40mg/kg SID (high-dose group, HDG), and nine cats were left untreated (control group, CG). The drug's levels in cats' plasma and hair were measured by a reversed-phase high performance liquid chromatographic method (RP-HPLC) and the cats' cure was followed by Wood's lamp illumination, microscopic exam and fungal culture. We showed no difference between the clinical course in CG and LDG, but HDG were significantly differentiated from both other groups. Terbinafine levels in plasma at 120 days of treatment were not statistically different among LDG (4.13 microg/l) and HDG (5.48 microg/l), but levels in hair of LDG (1.24 microg/l) and HDG (3.62 microg/l) were significantly different. Terbinafine can be used for the treatment of microsporosis in cats in the dose of 30-40mg/kg SID.
authors.affiliation: Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Gerbiceva 60, 1000, Ljubljana, Slovenia.
authors.forename: T
authors.initials: T
authors.lastname: Kotnik
authors.forename: N
authors.initials: N
authors.lastname: Kozuh Erzen
authors.forename: J
authors.initials: J
authors.lastname: Kuzner
authors.forename: M
authors.initials: M
authors.lastname: Drobnic-Kosorok
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000382:microbiology; D002415:Cats; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D005260:Female; D006197:Hair / Q000737:chemistry; D008297:Male; D008864:Microsporum / Q000187:drug effects*; D009281:Naphthalenes / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D000077291:Terbinafine; D014005:Tinea / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D015047:Zoonoses
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine