Leukocyte transendothelial migration: orchestrating the underlying molecular machinery.
Transendothelial migration of leukocytes involves the spatiotemporal regulation of adhesion molecules, chemokines and cytoskeletal regulators. Recent results show that distinct steps of leukocyte transendothelial migration are regulated by sequential integrin activation and coordinated Rho family GTPase activity. Progress has been made in understanding how the dynamic regulation of these molecules translates into leukocyte transmigration.
Worthylake
R A
RA
Department of Cell and Developmental Biology, CB #7090, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. becky_worthylake@med.unc.edu
Burridge
K
K
D015815:Cell Adhesion Molecules / Q000378:metabolism; D002465:Cell Movement; D018925:Chemokines / Q000502:physiology; D002634:Chemotaxis, Leukocyte; D003599:Cytoskeleton / Q000502:physiology; D004730:Endothelium, Vascular / Q000276:immunology*; D006801:Humans; D016023:Integrins / Q000502:physiology; D008954:Models, Biological; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
D015815:Cell Adhesion Molecules; D018925:Chemokines; D016023:Integrins; D020742:rhoA GTP-Binding Protein