[Endothelial dysfunction and its clinical significance (new trend in cardiology)].
The authors present the results of experimental and clinical trials of recombinant genes coding the synthesis of endothelial growth factors VEGF, bFGF. Single transendocardial administration of these genes' DNA into the zone of hybernating myocardium in some patients with CHD caused in 3-6 months significant increase in perfusion, left ventricular ejection fraction, decrease in stenocardic pang rate, increase in exercise tolerance. The marked clinical effect was achieved when these drugs were introduced into ischemized tissue in patients with obliterating atherosclerosis of lower extremity arteries. Development of the methods for studying endothelial function available for wide clinical practice will permit to raise the efficiency of initial and secondary prophylaxis of arterial hypertension, CHD. Today the evaluation and correction of endothelial dysfunction is the new and the most perspective direction in cardiology development.
Kolomoets
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D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000209:etiology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents