title: Neurohumoral mechanism of space motion sickness.
abstract: This paper reviews existing hypotheses concerning the mechanisms of adaptation of the vestibular apparatus and related somatosensory systems to microgravity with reference to the flight data. Having in view theoretical concepts and experimental data accumulated in space flights, a conceptual model of the development of a funtional system responsible for the termination of vestibular dysfuntion and space motion sickness manifestations is presented. It is also shown that changes in the hormonal status during motion sickness induced by vestibular stimulation give evidence that endocrine regulation of certain functions can be involved in adaptive responses.
authors.affiliation: Institute of Biomedical Problems, Moscow, USSR.
authors.forename: A I
authors.initials: AI
authors.lastname: Grigoriev
authors.forename: A D
authors.initials: AD
authors.lastname: Egorov
authors.forename: I A
authors.initials: IA
authors.lastname: Nichiporuk
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000344:Afferent Pathways; D000818:Animals; D004198:Disease Susceptibility; D004525:Efferent Pathways; D005133:Eye Movements; D006728:Hormones / Q000097:blood / Q000378:metabolism*; D006801:Humans; D009424:Nervous System Physiological Phenomena; D012399:Rotation; D013026:Space Flight; D018489:Space Motion Sickness / Q000209:etiology / Q000503:physiopathology*; D014722:Vestibule, Labyrinth / Q000502:physiology*; D014893:Weightlessness / Q000009:adverse effects*
chemical_list: D006728:Hormones