title: [Protective effects of gangliosides on cerebral neuronal damage of rat during acute hypoxia].
abstract: OBJECTIVE
  To observe the preventive and therapeutic effects of gangliosides on acute altitude hypoxic brain damage.
  
  
  METHODS
  Fifteen Wistar rats, weighed 180-220 g, were randomly divided into 3 groups, hypoxia group A, hypoxia group B and normoxia group. The rats in hypoxia group A were exposed to a simulated altitude of 7000 m for 5 hours and the rats in hypoxia group B were exposed to hypoxia after intraperitoneal administration of mixed gangliosides (100 mg/kg/d) for 3 days.
  
  
  RESULTS
  Gangliosides could ameliorate the severity of damage in neuronal bodies, cellular skeletons and synapses, especially in synapses.
  
  
  CONCLUSIONS
  It is suggested that gangliosides are effective in preventing and treating hypoxic brain damages by decreasing the accumulation of intracellular Ca2+, and stabilizing CaM and CaM PKII activity during acute hypoxia.
authors.affiliation: Institute of Hygiene and Environmental Medicine Academy of Military Medical Sciences, Tianjin, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Xie
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: X M
authors.initials: XM
authors.lastname: Yang
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Yin
authors.forename: J W
authors.initials: JW
authors.lastname: Bai
authors.forename: H X
authors.initials: HX
authors.lastname: Yang
mesh_terms: D000532:Altitude Sickness / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D001274:Atmospheric Pressure; D002540:Cerebral Cortex / Q000503:physiopathology / Q000648:ultrastructure; D005732:Gangliosides / Q000627:therapeutic use*; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000517:prevention & control; D008928:Mitochondria; D009474:Neurons / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000648:ultrastructure
chemical_list: D005732:Gangliosides