title: Disuse and aging:  same problem, different outcomes.
abstract: Many of the changes that accompany physical inactivity coincide with those that occur during aging.  These changes are generally grouped under the term of 'disuse' (or "lack of use" or "inappropriately modulated stimulation").  Studies of long-term space travel have revealed that weightlessness in space also induces changes resembling those of aging and physical inactivity.  The relationship between disuse (due to bed rest, insufficient exercise, or lack of gravity) and aging has some definite practical implications.  As life expectancy is lenghtened in all populations worldwide, the number of elderly with varying degrees of disability leading to reduced physical activity also increases.  Changes induced by bed rest as a consequence of disease may also be superimposed on aging changes and further diminish physiologic reserves and accelerate pathology.  Therefore, the study of disuse, irrespective of its etiology, may serve as a model for understanding not only some of the functional changes induced by lack of activity and/or gravity but also some of the disabilities of old age.  Indeed, a better understanding of disuse phenomena will make it possible to establish programs of prevention and rehabilitation that will ameliorate both disuse and aging deficits.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Timiras
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000818:Animals; D001510:Bed Rest / Q000009:adverse effects*; D006233:Persons with Disabilities; D015444:Exercise / Q000502:physiology*; D005260:Female; D016330:Frail Elderly; D006801:Humans; D007103:Immobilization / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D051381:Rats; D012146:Rest