title: Synthesis and evaluation of prolyl carbamate nucleic acids (PrCNA).
abstract: Carbamate linked prolyl nucleic acids are obtained in high yield and purity under mild conditions in solution and solid phase. p-Nitrophenylchloroformate is used as the activating reagent for alcohol. Homooligomers of PrCNA do not bind to DNA. The introduction of this modification in PNA sequences destabilizes the triplexes, inspite of enhancement in the base stacking.
authors.affiliation: Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India.
authors.lastname: Meena
authors.forename: V A
authors.initials: VA
authors.lastname: Kumar
authors.forename: K N
authors.initials: KN
authors.lastname: Ganesh
mesh_terms: D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002942:Circular Dichroism; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D002219:Carbamates; D020135:Peptide Nucleic Acids; D011392:Proline