title: Influence of longitudinal whole animal clinorotation on lens, tail, and limb regeneration in urodeles.
abstract: Two species of newts (Urodela) and two types of clinostats for fast clinorotation (60 rpm) were used to investigate the influence of simulated weightlessness on regeneration and to compare results obtained with data from spaceflight experiments.  Seven or fourteen days of weightlessness in Russian biosatellites caused acceleration of lens and limb regeneration by an increase in cell proliferation, differentiation, and rate of morphogenesis in comparison with ground controls.  After a comparable time of clinorotation the results obtained with Triturus vulgaris using a horizontal clinostat were similar to those found in spaceflight.  In contrast, in Pleurodeles waltl using both horizontal and radial clinostats the results were contradictory compared to Triturus.  We speculate that different levels of gravity or/and species specific thresholds for gravitational sensitivity could be responsible for these contradictory results.
authors.affiliation: Zoological Institute, University of Cologne, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Anton
authors.forename: E N
authors.initials: EN
authors.lastname: Grigoryan
authors.forename: V I
authors.initials: VI
authors.lastname: Mitashov
mesh_terms: D000818:Animals; D002455:Cell Division; D005134:Eye Neoplasms / Q000473:pathology; D005552:Forelimb / Q000166:cytology / Q000502:physiology*; D006112:Gravitation; D007908:Lens, Crystalline / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D008545:Melanoma / Q000473:pathology; D010999:Pleurodeles / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D012399:Rotation; D013026:Space Flight; D013623:Tail / Q000166:cytology / Q000502:physiology*; D014319:Triturus / Q000502:physiology; D014893:Weightlessness; D018474:Weightlessness Simulation / Q000379:methods