FR901469, a novel antifungal antibiotic from an unidentified fungus No. 11243. III. Structure determination.
A novel antifungal antibiotic, FR901469, was isolated from an unidentified fungus No. 11243. It is a water-soluble 40-membered macrocyclic lipopeptidolactone, consisting of D-Ala, L-Tyr, L-Val, trans-4OH-L-Pro, trans-3OH-L-Pro, threo-3OH-L-Gln, Gly, L-Orn, L-Thr, three residues of D-alloThr and a (3R)-hydroxypalmitic acid. Its structure, including absolute configurations, was unequivocally determined as 1 based on chemical and spectroscopic evidence.
Fujie
A
A
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Muramatsu
H
H
Yoshimura
S
S
Hashimoto
M
M
Shigematsu
N
N
Takase
S
S
D000935:Antifungal Agents / Q000737:chemistry*; D047630:Depsipeptides; D005658:Fungi / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000737:chemistry*; D055666:Lipopeptides
D000935:Antifungal Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C417112:FR 901469; D055666:Lipopeptides