title: Psychosocial and endocrine features of chronic first-episode major depression in 8-16 year olds.
abstract: BACKGROUND
  Psychoendocrine processes may have a role in explaining individual differences in the outcome of major depression in 8-16-year-old school children.
  
  
  METHODS
  Salivary cortisol and dehydroepiandrosterone (DHEA) levels at 8:00 AM and 8:00 PM, life events, and comorbidity were assessed at presentation, 36, and 72 weeks in 47 (60%) of 78 clinically referred subjects with a first episode of major depression. Comparisons were made between chronic and nonchronic major depression.
  
  
  RESULTS
  Chronic depression was characterized by being older, cortisol hypersecretion at 8:00 PM at all three assessments, increasing depression-dependent life events over the follow-up period, and comorbid obsessive-compulsive disorder (OCD) at presentation and at 36 weeks. Chronicity may be best predicted by increasing depression-dependent events over the 72-week period. Such events are more likely in cases with evening cortisol hypersecretion at entry and persistent OCD. Variations in DHEA levels were not associated with chronicity or increasing life events.
  
  
  CONCLUSIONS
  During adolescence, but not childhood, the persistence of major depression may occur through an increase of risk for further and particular types of depression-dependent undesirable life events (personal disappointments and/or dangers to the self), that are more likely in those subjects with persisting cortisol hypersecretion and unresolved comorbid OCD.
authors.affiliation: Developmental Psychiatry Section, Department of Psychiatry, University of Cambridge, Cambridge CB2 2AH, UK.
authors.forename: I M
authors.initials: IM
authors.lastname: Goodyer
authors.forename: R J
authors.initials: RJ
authors.lastname: Park
authors.forename: J
authors.initials: J
authors.lastname: Herbert
mesh_terms: D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D002940:Circadian Rhythm / Q000502:physiology; D015897:Comorbidity; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008016:Life Change Events; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D010552:Personality Assessment; D012307:Risk Factors; D012463:Saliva / Q000378:metabolism
chemical_list: D003687:Dehydroepiandrosterone; D006854:Hydrocortisone