Cytotoxic alkaloids and a flavan from the bulbs of Crinum asiaticum var. japonicum.
A new pyrrolophenanthridone alkaloid, criasiaticidine A (1), was isolated from the bulbs of Crinum asiaticum var. japonicum, together with pratorimine (2), lycorine (3) and 4'-hydroxy-7-methoxyflavan (4). The structure of the new alkaloid was determined to be 4,5-etheno-9,10-dihydroxy-6-phenanthridone by spectroscopic means. The cytotoxicity of the isolated compounds 1-4 was evaluated in vitro against Meth-A (mouse sarcoma) and Lewis lung carcinoma (mouse lung carcinoma) tumor cell lines. Furthermore, 3 was examined for in vivo antitumor activity with LLC tumor cells.
Min
B S
BS
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
Gao
J J
JJ
Nakamura
N
N
Kim
Y H
YH
Hattori
M
M
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002853:Chromatography, Liquid; D005260:Female; D007202:Indicators and Reagents; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010616:Phenanthrenes / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D010616:Phenanthrenes; C446979:criasiaticidine A