title: Effects of intravenous lidocaine overdose on cardiac electrical activity and blood pressure in the horse.
abstract: This study aimed to identify blood serum lidocaine concentrations in the horse which resulted in clinical signs of intoxication, and to document the effects of toxic levels on the cardiovascular and cardiopulmonary systems. Nineteen clinically normal mature horses of mixed breed, age and sex were observed. Lidocaine administration was initiated in each subject with an i.v. loading dose of 1.5 mg/kg bwt and followed by continuous infusion of 0.3 mg/kg bwt/min until clinical signs of intoxication were observed. Intoxication was defined as the development of skeletal muscle tremors. Prior to administration of lidocaine, blood samples for lidocaine analysis, heart rate, mean arterial blood pressure, systolic blood pressure, diastolic blood pressure, respiratory rate and electrocardiographic (ECG) data were collected. After recording baseline data, repeat data were collected at 5 min intervals until signs of intoxication were observed. The range of serum lidocaine concentrations at which the clinical signs of intoxication were observed was 1.85-4.53 microg/ml (mean +/- s.d. 3.24 +/- 0.74 microg/ml). Statistically significant changes in P wave duration, P-R interval, R-R interval and Q-T interval were observed in comparison to control values, as a result of lidocaine administration. These changes in ECG values did not fall outside published normal values and were not clinically significant. Heart rate, blood pressures and respiratory rates were unchanged from control values. This study establishes toxic serum lidocaine levels in the horse, and demonstrates that there were no clinically significant cardiovascular effects with serum lidocaine concentrations less than those required to produce signs of toxicity.
authors.affiliation: Auburn University College of Veterinary Medicine, Department of Large Animal Surgery and Medicine, Alabama 36849-5522, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Meyer
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.forename: R R
authors.initials: RR
authors.lastname: Hanson
authors.forename: T L
authors.initials: TL
authors.lastname: Hayes
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D062787:Drug Overdose / Q000503:physiopathology / Q000662:veterinary; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006734:Horse Diseases / Q000139:chemically induced* / Q000503:physiopathology; D006736:Horses; D007275:Injections, Intravenous / Q000662:veterinary; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D008297:Male; D012016:Reference Values; D012119:Respiration / Q000187:drug effects; D012129:Respiratory Function Tests
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine