title: [Nonsteroidal antirheumatic agents--present status and perspectives].
abstract: The non-steroidal anti-inflammatory drugs (NSAID) are most commonly used drugs in rheumatology. NSAID effectively reduce the pain and inflammation. However, the use of NSAIDs is associated with various gastrointestinal side effects. The discovery of the two COX isoforms, namely COX1 (constitutive) and COX2 (inducible) led to the search for specific COX2 inhibitors with better gastrointestinal safety. Beside the simply gastrointestinal safety the issue point to the still not resolved questions about coxibs effects on the constitutive COX2 function in brain, kidney and the reproductive tract, as well as vigilance in post-marketing surveillance.
authors.affiliation: Klinika za reumatske bolesti i rehabilitaciju Medicinskoga fakulteta Sveucilista u Zagrebu KBC Zagreb, Zagreb.
authors.forename: B
authors.initials: B
authors.lastname: Curković
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D012216:Rheumatic Diseases / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors