Stupor from lamotrigine toxicity.
OBJECTIVE
To report that acute lamotrigine poisoning may result in severe encephalopathy.


METHODS
A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.


RESULTS
LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels.


CONCLUSIONS
LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status.
Sbei
M
M
Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Campellone
J V
JV
D000927:Anticonvulsants / Q000506:poisoning* / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced*; D062787:Drug Overdose / Q000523:psychology; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology; D013406:Suicide, Attempted / Q000523:psychology*; D014227:Triazines / Q000506:poisoning* / Q000627:therapeutic use; D014635:Valproic Acid / Q000506:poisoning
D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000077213:Lamotrigine