Second trimester pregnancy termination with 800 mcg vaginal misoprostol.
OBJECTIVE
To demonstrate the efficacy of 800 microgram vaginal misoprostol tablet for second trimester pregnancy termination.


METHODS
Prospective descriptive study.


METHODS
Maharaj Nakorn Chiang Mai Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University.


METHODS
Pregnant women meeting the inclusion criteria including (1) singleton pregnancy with live fetus, (2) gestational age of 14-28 weeks, (3) indication for therapeutic termination, (4) closed and uneffaced cervix, (5) absence of uterine contraction and leakage of amniotic fluid, (6) no previous classical uterine scar, (7) no contraindication for misoprostol such as hypersensitivity.


METHODS
800 microgram misoprostol tablet intravagina every 12 hours.


METHODS
Mean induction delivery time, mean abortion time, maternal side effects.


RESULTS
The mean induction delivery time was 21.38 + 13.68 hours, mean abortion time was 21.56 +/- 13.68 hours. Diarrhea was the most common side effect occuring in 40 per cent of patients.


CONCLUSIONS
800 mcg vaginal misoprostol every 12 hours is effective but if we want high efficacy along with fewer side effects, lower dose and interval should be further studied.
Pongsatha
S
S
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.
Tongsong
T
T
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol