The ACVD task force on canine atopic dermatitis (IX): the controversy surrounding the route of allergen challenge in canine atopic dermatitis.
For decades, the dogma that environmental allergens trigger cutaneous inflammation led to the denomination of canine atopic dermatitis as "allergic inhalant dermatitis". Definitive proof for a respiratory route of allergen challenge is lacking, however. Recent observations suggest, in fact, that skin inflammation could occur because of epidermal allergenic contact. The aim of this paper is to review the evidence published in favor and against the two suspected routes of allergen provocation.
Olivry
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Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA. thierry_olivry@ncsu.edu
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D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology*; D000818:Animals; D003876:Dermatitis, Atopic / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology / Q000276:immunology*; D004285:Dogs; D006801:Humans; D019570:Inhalation Exposure; D012955:Societies, Medical; D014481:United States
D000485:Allergens