Unexpected results and recourse in process optimization of nucleoside 3'-O-succinates.
An improved and scalable protocol for the synthesis of 3'-O-succinates of nucleosides has been developed using succinic anhydride. As a result, formation of unwanted dimer has been completely eliminated and use of toxic and smelly reagents have been avoided during synthesis of nucleoside succinates. All succinates were isolated in pure state without silica gel column chromatography.
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Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, California 92008, USA.
Sanghvi
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D002850:Chromatography, Gel; D009705:Nucleosides / Q000138:chemical synthesis* / Q000302:isolation & purification; D013386:Succinates / Q000138:chemical synthesis* / Q000302:isolation & purification
D009705:Nucleosides; D013386:Succinates