title: N-cyanoimidazole and diimidazole imine:  water-soluble condensing agents for the formation of the phosphodiester bond.
abstract: The reaction of BrCN with imidazole results in the formation of N-cyanoimidazole and diimidazole imine.  These compounds were shown to be useful condensing agents for the formation of the phosphodiester bound in aqueous solution.
authors.affiliation: Department of Chemistry, Rensselaer Polytechnic Institute, Troy, NY 12180-3590, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Ferris
authors.forename: C H
authors.initials: CH
authors.lastname: Huang
authors.forename: W J
authors.initials: WJ
authors.lastname: Hagan
mesh_terms: D000227:Adenine Nucleotides / Q000138:chemical synthesis*; D000249:Adenosine Monophosphate / Q000737:chemistry*; D017605:Bromine Compounds / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry; D019143:Evolution, Molecular; D007093:Imidazoles / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D012313:RNA / Q000138:chemical synthesis
chemical_list: D000227:Adenine Nucleotides; D017605:Bromine Compounds; D003486:Cyanides; D007093:Imidazoles; D007097:Imines; D000249:Adenosine Monophosphate; D012313:RNA; C010565:2',3'-cyclic AMP; C051673:N-cyanoimidazole