HLA-DQ alleles in patients with celiac disease in Turkey.
The prevalence of the HLA-DQA1 and DQB1 alleles in 55 Turkish children with celiac disease and 50 control subjects was investigated by using an allele-specific DNA-based polymerase chain reaction-sequence-specific primer (PCR-SSP) method. The frequency of the DQA1*0501 and DQB1*02 alleles was higher in celiac patients than in controls. The DQA1B1 (*0501; *02) haplotype was present in 46 (83.6%) patients and only in 12 (24%) controls. The remaining 9 celiac patients which were negative for DQA1B1 (*0501;*02) carried the DQA1B1 (*03;*0302) haplotype. We found an excess homozygosity of the DQB1*02 allele and the DQA1B1 (*0501;*02) haplotype in the patients. No statistically significant correlation was found between the homozygosity of this haplotype or the DQB1*02 allele and an earlier onset of the disease.
Tüysüz
B
B
Division of Genetics, Department of Pediatrics, Cerrahpaşa Faculty of Medicine, University of Istanbul, Istanbul, Turkey.
Dursun
A
A
Kutlu
T
T
Sökücü
S
S
Cine
N
N
Süoğlu O
Erkan
T
T
Erginel-Unaltuna
N
N
Tümay
G
G
D000293:Adolescent; D000483:Alleles; D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology; D002648:Child; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D008297:Male; D018807:Polymorphism, Single-Stranded Conformational; D014421:Turkey
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen