Revised interpretation of the immunological results obtained with pneumococcal polysaccharide 17F derived synthetic di-, tri- and tetrasaccharide conjugates in mice and rabbits.
Recently, the structure for pneumococcal polysaccharide (PS) 17F has been revised. Based on the former PS structure, immunogenicities of PS 17F derived synthetic di-, tri- and tetrasaccharide conjugates have been reported in mice. Here, we present additional data on the immunogenicities of these conjugates in rabbits and re-evaluate the immunogenicity results in the light of the revised PS 17F structure.
Jansen
W T
WT
Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, Vaccines Section, Utrecht University Hospital, 3584 CX, Utrecht, The Netherlands. jwo@gbf.de
Verheul
A F
AF
Veeneman
G H
GH
van Boom
J H
JH
Snippe
H
H
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology; D002240:Carbohydrate Sequence; D007115:Immunization Schedule; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000276:immunology*; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000276:immunology; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate; D014614:Vaccines, Synthetic; C094780:pneumococcal polysaccharide type 17F