COP9 signalosome revisited: a novel mediator of protein degradation.
The COP9 signalosome is an evolutionarily conserved multiprotein complex that was first identified as an essential complex that represses light-regulated development in Arabidopsis. The COP9 signalosome has similarity to the lid of the 19S regulatory particle of the 26S proteasome and has recently been shown to interact with SCF-type E3 ubiquitin ligases. Although its precise role in the process of protein degradation remains to be established, the COP9 signalosome is a positive regulator of E3 ubiquitin ligases that functions at least in part by mediating the deconjugation of the NEDD8/RUB-modification from the cullin subunit of SCF-type E3 complexes. Here, we discuss these recent findings, which add an additional component to the biology of substrate-specific protein degradation.
Schwechheimer
C
C
Zentrum für Molekularbiologie der Pflanzen, Abteilung Entwicklungsgenetik, Universität Tübingen, Auf der Morgenstelle 1, D-72076, Tübingen, Germany.
Deng
X W
XW
D000818:Animals; D017360:Arabidopsis; D029681:Arabidopsis Proteins; D000075686:COP9 Signalosome Complex; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins; D006801:Humans; D008025:Ligases / Q000378:metabolism; D008954:Models, Biological; D046912:Multiprotein Complexes; D000075687:NEDD8 Protein; D010447:Peptide Hydrolases / Q000737:chemistry / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D017434:Protein Structure, Tertiary; D021122:Protein Subunits; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D012568:Schizosaccharomyces; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism*
D029681:Arabidopsis Proteins; D029721:Drosophila Proteins; D046912:Multiprotein Complexes; D000075687:NEDD8 Protein; C082860:NEDD8 protein, human; C513173:Nedd8 protein, Drosophila; D021122:Protein Subunits; D011506:Proteins; C513170:RUB1 protein, Arabidopsis; D014452:Ubiquitins; D044767:Ubiquitin-Protein Ligases; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease; D008025:Ligases