Photosensitized and catalytic oxidation of DNA by metallophthalocyanine-oligonucleotide conjugates.
The synthesis of new metallophthalocyanine-oligonucleotide conjugates is reported. These conjugates can cause sequence-specific photosensitized or catalytic oxidation of DNA by molecular oxygen.
Koval
V V
VV
Institute of Bioorganic Chemistry, Lavrentyev Ave. 8, Novosibirsk, 630090, Russia.
Chernonosov
A A
AA
Abramova
T V
TV
Ivanova
T M
TM
Fedorova
O S
OS
Derkacheva
V M
VM
Lukyanets
E A
EA
D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D054833:Isoindoles; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D010777:Photochemistry; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry*
D007211:Indoles; D054833:Isoindoles; D009841:Oligonucleotides; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; D004247:DNA; C013647:phthalocyanine