title: Magnetic resonance imaging of myocardial perfusion in single-vessel coronary artery disease: implications for transmural assessment of myocardial perfusion.
abstract: The purpose of the study was to investigate the potential of magnetic resonance imaging (MRI) to assess transmural differences in myocardial perfusion. Contrast-enhanced MRI was performed at rest and during hyperemia in a dog model and in 22 patients with single-vessel coronary artery disease. From MR signal intensity-versus-time curves, three perfusion parameters were derived: maximum myocardial contrast enhancement (MCE), slope, and inverse mean transit time (1/MTT). In dogs, MCE correlated well (r = 0.87, p < 0.00001) with microsphere-assessed myocardial blood flow. In the patients, the subendocardial MCE decreased during hyperemia (0.89 +/- 0.18 vs. 0.74 +/- 0.15, p < 0.003) and was lower in subendocardium than in subepicardium (0.74 +/- 0.15 vs. 0.84 +/- 0.21, p < 0.02). Parameters slope and 1/MTT paralleled MCE. Contrast-enhanced MRI reflects the transmural redistribution of myocardial perfusion during hyperemia. Perfusion abnormalities can be identified most distinctly in subendocardial myocardium.
authors.affiliation: Department of Cardiology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: J T
authors.initials: JT
authors.lastname: Keijer
authors.forename: A C
authors.initials: AC
authors.lastname: van Rossum
authors.forename: N
authors.initials: N
authors.lastname: Wilke
authors.forename: M J
authors.initials: MJ
authors.lastname: van Eenige
authors.forename: M
authors.initials: M
authors.lastname: Jerosch-Herold
authors.forename: J G
authors.initials: JG
authors.lastname: Bronzwaer
authors.forename: C A
authors.initials: CA
authors.lastname: Visser
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D003287:Contrast Media; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016018:Least-Squares Analysis; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008863:Microspheres; D008875:Middle Aged
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA