Hematologic masquerade of rhabdomyosarcoma.
We present the case of a 12-year-old boy admitted with the diagnosis of acute leukemia, but found to have an infiltration of the marrow by an alveolar rhabdomyosarcoma (RMS) as determined by the cytogenetic demonstration of a t(2;13)(q25;q14). A primary tumor could not be found. With this case as a basis, we have tabulated features of all similar cases in the literature and discuss the possible optimal approaches to establishing the correct diagnosis in such patients.
Sandberg
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Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, USA. jvaugha@chw.edu
Stone
J F
JF
Czarnecki
L
L
Cohen
J D
JD
D000208:Acute Disease; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D020732:Cytogenetic Analysis; D003937:Diagnosis, Differential; D006801:Humans; D007938:Leukemia / Q000175:diagnosis*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D009382:Neoplasms, Unknown Primary; D011650:Pulmonary Alveoli; D012208:Rhabdomyosarcoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D014178:Translocation, Genetic