title: Oligonucleotides with isopolar phosphonate internucleotide linkage: a new perspective for antisense compounds?
abstract: Several types of isopolar modified oligothymidylates and oligoadenylates (15 mers) with the phosphonate -O-P-CH2-O- internucleotide linkage were prepared. The modified oligonucleotides were subjected to the study of their hybridization properties, resistance against nucleases, and the ability to elicit RNase H activity.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
authors.forename: D
authors.initials: D
authors.lastname: Rejman
authors.forename: J
authors.initials: J
authors.lastname: Snásel
authors.forename: R
authors.initials: R
authors.lastname: Liboska
authors.forename: Z
authors.initials: Z
authors.lastname: Tocík
authors.forename: O
authors.initials: O
authors.lastname: Paces
authors.forename: S
authors.initials: S
authors.lastname: Králíková
authors.forename: M
authors.initials: M
authors.lastname: Rinnová
authors.forename: P
authors.initials: P
authors.lastname: Kois
authors.forename: I
authors.initials: I
authors.lastname: Rosenberg
mesh_terms: D000249:Adenosine Monophosphate / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D063065:Organophosphonates / Q000737:chemistry*; D016914:Ribonuclease H / Q000378:metabolism; D013938:Thymidine Monophosphate / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D016376:Oligonucleotides, Antisense; D063065:Organophosphonates; D013938:Thymidine Monophosphate; D000249:Adenosine Monophosphate; D016914:Ribonuclease H