[Antioxidant properties of 3-oxypyridine analogues: mexidol, emoxipin, proxipin].
Using three chemiluminescent model systems of oxidation (suspension of phospholipid liposomes, a geous solution of haemoglobin-hydrogen peroxide-luminol and a geous solution 2,2'-azo-bis-(2-methylpropionamidine)dihydrochloride-luminol) the antioxidant activity and mechanism of antioxidant action of three 3-oxypyridine analogues: (mexidol, emoxipin and proxipin) were studied. These compounds were shown: a) to interact with catalitically active two valency iron ions (Fe2+), that causes elimination of ions from the model system; b) to scavenge reactive oxygen species and/or luminol radicals produced in the model systems. Their activity reduced in the following order: mexidol > emoxipin > proxipin. The antioxidant activity of 3-oxypyridines may underline known clinical effects of these compounds.
Klebanov
G I
GI
Department of Biophysic, Russian State Medical University, Ostrovityanova ul. 1, Moskow, 119869, Russia. klebanov@fbm.msu.ru
Liubitskiĭ
O B
OB
Vasil'eva
O V
OV
Klimov
Iu V
IuV
Penzulaeva
O B
OB
Tepliashin
A S
AS
Tolstykh
M P
MP
Promorenko
V K
VK
Vladimirov
Iu A
IuA
D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D015227:Lipid Peroxidation; D010847:Picolines / Q000737:chemistry / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism*; D017382:Reactive Oxygen Species
D000975:Antioxidants; D010847:Picolines; D011725:Pyridines; D017382:Reactive Oxygen Species; C014047:hydroxypyridines; C070020:emoxypine succinate; D007501:Iron; C009820:6-methyl-2-ethyl-3-hydroxypyridine