title: Sweet successes.
abstract: Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities. Sweet compounds may be distinguished through differential expression of sweet receptors. Novel heterologous expression systems to test bitter and sweet modalities now provide the tools necessary for understanding taste coding.
authors.affiliation: Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Lewcock
authors.forename: R R
authors.initials: RR
authors.lastname: Reed
mesh_terms: D000818:Animals; D006801:Humans; D013549:Sweetening Agents; D013649:Taste / Q000502:physiology*; D013650:Taste Buds / Q000502:physiology*
chemical_list: D013549:Sweetening Agents