title: A highly efficient 24-condition matrix for the crystallization of nucleic acid fragments.
abstract: A matrix screen is presented with optimized conditions for the crystallization of nucleic acid fragments.  The screen consists of 24 conditions only and utilizes minimal amounts of sample.  It has been tested on a series of DNA and RNA oligomers, and yielded diffraction-quality crystals of many specimens including drug-DNA complexes.  Preliminary X-ray analysis of the crystals is reported.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02141, USA.
authors.forename: I
authors.initials: I
authors.lastname: Berger
authors.forename: C H
authors.initials: CH
authors.lastname: Kang
authors.forename: N
authors.initials: N
authors.lastname: Sinha
authors.forename: M
authors.initials: M
authors.lastname: Wolters
authors.forename: A
authors.initials: A
authors.lastname: Rich
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D003460:Crystallization; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D012313:RNA; D004247:DNA