title: The involvement of cerebrovascular reactivity in pathogenesis of space motion sickness.
abstract: The aim of the presented work is to investigate the mechanisms of involvement of cerebral circulation in pathogenesis of space motion sickness.  In experiments on chronic rabbits the 2-hours rocking and antiorthostasis served as a model of influences of the zero-gravity conditions intracranial hemo- and liquorodynamics.  Cerebravascular reactivity was evaluated as a response of cerebral blood flow and intracerebral rheoencephalography to functional loads (photostimulation, CO2-inhalation, Stookey test).  Shifts of water balance in the brain tissue has been assessed by means of three-frequency brain electrical impedance.  Rocking plus aniorthostatis resulted in decrease of the cerebrovascular reactivity and hyperhydration.  The data obtained show a significant decrease of compensatory abilities of the cerebrovascular system under the zero-gravity conditions.
authors.affiliation: Institute of Evolutionary Physiology and Biochemistry, Acad. Sci. USSR, Leningrad.
authors.lastname: Moskalenko YuE
authors.forename: A I
authors.initials: AI
authors.lastname: Beketov
authors.forename: G B
authors.initials: GB
authors.lastname: Weinstein
authors.forename: V F
authors.initials: VF
authors.lastname: Maximuk
authors.forename: N A
authors.initials: NA
authors.lastname: Skoromny
authors.forename: K K
authors.initials: KK
authors.lastname: Vasiljev
authors.forename: M V
authors.initials: MV
authors.lastname: Vorobjev
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology*; D017097:Electric Impedance; D018495:Fluid Shifts / Q000502:physiology*; D018475:Head-Down Tilt / Q000009:adverse effects*; D006439:Hemodynamics / Q000502:physiology; D009038:Motion; D011817:Rabbits; D018489:Space Motion Sickness / Q000209:etiology / Q000503:physiopathology*; D018474:Weightlessness Simulation / Q000009:adverse effects*