Synthesis of 8-amino and 8-substituted amino derivatives of acyclic purine nucleoside and nucleotide analogs. Alkylation of 8-substituted purine bases.
Two synthetic approaches were used for preparation of 8-amino-, 8-methylamino-, and 8-dimethylaminoadenine and -guanine analogs of PME and HPMP series: (a) direct modification of 8-bromopurine acyclic nucleotide analogs at the 8-position of the base, (b) alkylation of 8-modified purine bases with alkylation agents.
Janeba
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Z
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Holý
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A
D000225:Adenine / Q000031:analogs & derivatives; D000478:Alkylation; D006147:Guanine / Q000031:analogs & derivatives; D011684:Purine Nucleosides / Q000138:chemical synthesis*; D011685:Purine Nucleotides / Q000138:chemical synthesis*
D011684:Purine Nucleosides; D011685:Purine Nucleotides; D006147:Guanine; D000225:Adenine