title: Characteristic intracytoplasmic material in a perianal wart that contains human papillomavirus type 56 and 16 DNA.
abstract: We report the case of a perianal wart in which human papillomavirus type 56 and 16 DNAs were detected, arising in a 29-year-old healthy Japanese female. Clinically, moist erythema and small flat pinkish papules appeared around the anus and worsened over a period of 6 months. Histopathologically, no signs of dysplasia or atypia were apparent. An area of intracytoplasmic material, which was homogeneous and eosinophilic, was contained in each epidermal cell. The wart showed HPV-56 and HPV-16 DNAs by PCR and reverse-phase dot blot hybridization. Additional Southern blot analysis showed the amount of HPV-56 DNA to be more than 10 times that of HPV-16 DNA. This is the first case, to our knowledge, of a perianal wart with intracytoplasmic material, which contains HPV DNAs causing mucous lesions.
authors.affiliation: Department of Dermatology, Nagoya University School of Medicine, Nagoya, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Adachi
authors.forename: Y
authors.initials: Y
authors.lastname: Tomita
mesh_terms: D000328:Adult; D001004:Anus Diseases / Q000473:pathology / Q000821:virology*; D015139:Blotting, Southern; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis*; D014860:Warts / Q000473:pathology / Q000821:virology*
chemical_list: D012367:RNA, Viral