title: Studies on order in prebiological systems at the Laboratory of Chemical Evolution.
abstract: The basic tenet of investigations in the Laboratory of Chemical Evolution (LCE) under Cyril Ponnamperuma was that biology is a recapitulation of prebiology, and that protobiology is an outcome of simple molecular interactions, engendered by the physics and chemistry of the molecules themselves. Studies were undertaken to continue research into understanding the determining physical and chemical parameters of molecular interactions leading to increasing complexity in pre- and proto-biological systems. Among other, related work, research was performed on the origin of the genetic code, the origin of order in prebiotic polymers, and related studies on the origins of optical activity in biological macromolecules. Highlights of some these studies are presented here.
authors.forename: M K
authors.initials: MK
authors.lastname: Hobish
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D019418:Evolution, Chemical; D019143:Evolution, Molecular; D005815:Genetic Code; D007536:Isomerism; D007753:Laboratories; D009682:Magnetic Resonance Spectroscopy; D008396:Maryland; D009711:Nucleotides / Q000737:chemistry; D000069497:Origin of Life; D011108:Polymers / Q000737:chemistry; D012106:Research; D014495:Universities
chemical_list: D000596:Amino Acids; D009711:Nucleotides; D011108:Polymers