Inhibitory activity of lignan components from the flower buds of Magnoliae fargesii on the expression of cell adhesion molecules.
Inhibitory activity of lignans isolated from Magnoliae fargesii Cheng on cell adhesion molecules on the surface of THP-1 human monocytic cell lines were investigated. Among 16 lignan components tested, six displayed relatively potent inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).
Ahn
K S
KS
Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon.
Jung
K Y
KY
Kim
J H
JH
Oh
S R
SR
Lee
H K
HK
D000911:Antibodies, Monoclonal / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003864:Depression, Chemical; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D017705:Lignans / Q000494:pharmacology*; D029562:Magnoliaceae / Q000737:chemistry*; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D028321:Plant Preparations / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000494:pharmacology; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis*
D000911:Antibodies, Monoclonal; D017705:Lignans; D028321:Plant Preparations; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1