Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis.
We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF) concentration significantly. Also VEGF and TNF-alpha production by the activated peritoneal macrophages were enhanced. These results suggest that the anti-tumor activity of the D-Fraction is not only associated with the activation of the immuno-competent cells but also possibly related to the carcinoma angiogenesis induction.
Matsui
K
K
Department of Microbial chemistry, Kobe Pharmaceutical University, 19-1, Motoyama-kitamachi 4-chome, Higashinada-ku, 658-8558, Kobe, Japan.
Kodama
N
N
Nanba
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016228:Endothelial Growth Factors / Q000096:biosynthesis / Q000097:blood; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D005656:Fungal Proteins / Q000494:pharmacology*; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D008222:Lymphokines / Q000096:biosynthesis / Q000097:blood; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000139:chemically induced*; D011124:Polyporaceae / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D000970:Antineoplastic Agents; D016228:Endothelial Growth Factors; D005656:Fungal Proteins; D006023:Glycoproteins; D008222:Lymphokines; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors