title: Classical swine fever (CSF) marker vaccine. Trial II. Challenge study in pregnant sows.
abstract: The efficacy of two marker vaccines against classical swine fever (CSF) was tested in a large scale laboratory trial in several National Swine Fever Laboratories (NSFL) of the EU member states. The vaccines were: BAYOVAC CSF Marker (Vaccine A) from Bayer, Leverkusen, Germany and PORCILIS PESTI (Vaccine B) from Intervet, Boxmeer, The Netherlands. At the NSFL of Belgium, The Netherlands and Germany experiments were carried out to examine the ability of the vaccines to prevent transplacental transmission of CSF virus. In Belgium and The Netherlands pregnant sows were vaccinated once and challenged with virulent CSF virus 14 days later, which was around day 60 of gestation. At the NSFL in Germany sows were vaccinated twice, on days 25 and 46 of pregnancy and were challenged fourteen days after booster vaccination (day 60 of gestation). Apart from minor inflammatory reactions in some sows, no reactions post vaccination were noticed in either vaccine group. Sows vaccinated with Vaccine A were better protected against clinical CSF than sows vaccinated with Vaccine B. The antibody response after vaccination with Vaccine A was more pronounced than after vaccination with Vaccine B. After single vaccination six out of eight sows vaccinated with Vaccine A and all eight sows vaccinated with Vaccine B had viraemic piglets. After double vaccination one out of four litters from sows vaccinated with Vaccine A and four out of five litters from sows vaccinated with Vaccine B were found to be viraemic. However, both vaccines reduced the transmission probability significantly (Vaccine A: P=0.004, Vaccine B: P=0.024) after booster vaccination. However, Vaccine A appeared in this regard more potent as the estimated probability of fetal infections was lower. Nevertheless the risk of virus spreading after vaccination via transplacental transmission is still present and has to be addressed from an epidemiological point of view.
authors.affiliation: Federal Research Centre for Virus Diseases of Animals, Institute of Diagnostic Virology, Boddenblick 5a, D-17498, Insel Riems, Germany. depner@rie.bfav.de
authors.forename: K R
authors.initials: KR
authors.lastname: Depner
authors.forename: A
authors.initials: A
authors.lastname: Bouma
authors.forename: F
authors.initials: F
authors.lastname: Koenen
authors.forename: D
authors.initials: D
authors.lastname: Klinkenberg
authors.forename: E
authors.initials: E
authors.lastname: Lange
authors.forename: H
authors.initials: H
authors.lastname: de Smit
authors.forename: H
authors.initials: H
authors.lastname: Vanderhallen
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D006691:Classical Swine Fever / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D006692:Classical Swine Fever Virus / Q000276:immunology*; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000662:veterinary; D007117:Immunization, Secondary / Q000662:veterinary; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control / Q000662:veterinary*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000662:veterinary; D013552:Swine; D016896:Treatment Outcome; D014611:Vaccination / Q000662:veterinary; D022581:Vaccines, Marker / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014766:Viremia / Q000209:etiology / Q000662:veterinary; D017201:Virus Shedding
chemical_list: D000914:Antibodies, Viral; D022581:Vaccines, Marker; D014765:Viral Vaccines