[Analgesic effects of lornoxicam in formalin-induced inflammation].
Peroral administration of lornoxicam, a new representative of the class of oxicams, in a total dose of 2-16 mg/kg produced a dose-dependent analgesic effect in rats with formalin-induced tail inflammation, as confirmed by the tail-flick and hot-plate tests. The maximum analgesic effect of lornoxicam during the formalin-induced edema development was observed upon a three-fold drug administration by the scheme 1/2, 1/4, 1/4 of the total dose (8-16 mg/kg, p.o.) with a 3 h interval prior to formalin injection into the rat tail base. Validity of using the tail-flick and hot-plate methods for evaluation of the analgesic effect of NSAID is discussed.
Marusov
I V
IV
Valdman Institute of Pharmacology, Pavlov State Medical University, ul. L. Tolstogo 6/8, St. Petersburg, 197022 Russia.
Marusova
I B
IB
Pchelintsev
M V
MV
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D005557:Formaldehyde; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D010894:Piroxicam / Q000031:analogs & derivatives / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013623:Tail
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D005557:Formaldehyde; C059451:lornoxicam