Helicobacter pylori treatment: a role for probiotics?
Many new therapeutic strategies are studied to improve Helicobacter pylori eradication rate. Probiotics are live microorganisms which, upon administration, may interact with the human microflora and positively affect the health status. The use of probiotics in the field of H. pylori infection has been proposed for improving eradication rate and tolerability and for compliance of multiple antibiotic regimens used for the infection. Results from laboratory studies and from clinical trials seem to confirm the expectancies, but there is lack of standardization in terms of type of probiotic strain used, dosage and timing of supplementation. Before further ongoing trials and future studies will clarify these points, probiotics could remain a useful adjunct to standard anti-H. pylori therapies, but cannot take the place of other validated options.
Cremonini
F
F
Istituto di Patologia Medica, Policlinico Gemelli, Roma, Italia.
Canducci
F
F
Di Caro
S
S
Santarelli
L
L
Armuzzi
A
A
Gasbarrini
G
G
Gasbarrini
A
A
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D010349:Patient Compliance; D019936:Probiotics / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents