title: Dealkylation of phosphonate esters with chlorotrimethylsilane.
abstract: Chlorotrimethylsilane completely dealkylates phosphonate esters at elevated temperature in a sealed reaction vessel. These conditions are tolerated by a variety of functional groups and lead to high conversions of dimethyl, diethyl and diisopropyl phosphonates to their corresponding phosphonic acids.
authors.affiliation: Department of Chemical Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Gutierrez
authors.forename: E J
authors.initials: EJ
authors.lastname: Prisbe
authors.forename: J C
authors.initials: JC
authors.lastname: Rohloff
mesh_terms: D003640:Dealkylation; D063065:Organophosphonates / Q000737:chemistry*; D017905:Phosphites / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
chemical_list: D063065:Organophosphonates; D017905:Phosphites; D014297:Trimethylsilyl Compounds; C039293:trimethylchlorosilane; C047356:dimethyl hydrogen phosphite