Feeding responses to several neuropeptide Y receptor agonists in the neonatal chick.
Neuropeptide Y is one of the most potent neuropeptides known to induce feeding in animals, and has been suggested to be a physiological signal for food intake. It has been also reported that intracerebroventricular injection of neuropeptide Y stimulates feeding behavior of the neonatal chick. There are many neuropeptide Y receptor agonists that have not been investigated in feeding response of the neonatal chick. The aim of this study is to elucidate whether central injection of several neuropeptide Y receptor agonists stimulates feeding of the neonatal chick over 2 h. We found that central injections of [Leu(31), Pro(34)]neuropeptide Y, peptide YY, human pancreatic polypeptide and rat pancreatic polypeptide significantly stimulated food intake of neonatal chicks throughout the 2-h post-injection period. Neuropeptide Y-(13-36) significantly stimulated feeding at 30 min, but not thereafter. [D-Trp(32)]neuropeptide Y stimulated feeding at 60 and 120 min, but not 30 min, post-injection. Central administration of rat pancreatic polypeptide, which does not increase food intake in rats, stimulated feeding in chicks. This result reflects structural differences of the neuropeptide Y receptor subtypes and/or differences in mechanisms stimulating feeding behavior between mammals and chickens. In conclusion, neuropeptide Y receptor agonists, except for neuropeptide Y-(13-36), are potent stimulators of food intake in the neonatal chick.
Ando
R
R
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Kawakami
S I
SI
Bungo
T
T
Ohgushi
A
A
Takagi
T
T
Denbow
D M
DM
Furuse
M
M
D000818:Animals; D000831:Animals, Newborn; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D006801:Humans; D009478:Neuropeptide Y / Q000031:analogs & derivatives / Q000494:pharmacology; D010191:Pancreatic Polypeptide / Q000494:pharmacology; D019894:Peptide YY / Q000494:pharmacology; D051381:Rats; D017476:Receptors, Neuropeptide Y / Q000819:agonists*; D013997:Time Factors
D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; D019894:Peptide YY; C062259:neuropeptide Y, Leu(31)-Pro(34)-; C086545:neuropeptide Y, Trp(32)-; D010191:Pancreatic Polypeptide