A new FACIT of the collagen family: COL21A1.
Interrogation of the Human Genome data for sequences related to the von Willebrand factor A-domain module identified a previously unreported 4.1 kb full-length cDNA that is predicted to encode a new member of the collagen superfamily of extracellular matrix proteins, collagen XXI. The domain organization of collagen XXI comprised an N-terminal signal sequence, followed by single von Willebrand factor A-domain and thrombospondin domains, and an interrupted collagen triple helix. The organization of these motifs predict that collagen XXI is a new member of the FACIT collagen sub-family. Expression analysis indicated that COL21A1 mRNA is present in many tissues including heart, stomach, kidney, skeletal muscle and placenta, and radiation hybrid mapping localized the COL21A1 gene to 6p11-12.
Fitzgerald
J
J
Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, 3052 Parkville, Vic., Australia. fitzgerj@cryptic.rch.unimelb.edu.au
Bateman
J F
JF
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D002896:Chromosomes, Human, Pair 6; D003094:Collagen / Q000737:chemistry* / Q000235:genetics; D018076:DNA, Complementary / Q000378:metabolism; D016208:Databases, Factual; D005109:Extracellular Matrix / Q000378:metabolism; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D005810:Multigene Family; D010641:Phenotype; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D019699:Thrombospondins / Q000378:metabolism; D014018:Tissue Distribution; D014841:von Willebrand Factor / Q000378:metabolism
D018076:DNA, Complementary; D012333:RNA, Messenger; D019699:Thrombospondins; D014841:von Willebrand Factor; D003094:Collagen