title: Mathematical modeling of acute and chronic cardiovascular changes during Extended Duration Orbiter (EDO) flights.
abstract: The Extended Duration Orbiter (EDO) program aims to extend the capability of the Shuttle orbiter beyond its current 7-10 day limit on mission duration.  This goal is to be accomplished in steps, partly due to our limited knowledge of the physiological changes resulting from long-term exposure to weightlessness and their likely influence on critical mission operations involved in EDO flights.  Answers to questions related to physiologic adaptation to weightlessness are being actively sought at the present time to help implement the EDO program.  In the cardiovascular area, the loss of orthostatic tolerance is a medical concern because of its potential adverse effects on crew performance and safety during reentry and following return to earth.  Flight and ground-based physiologic studies are being planned to understand the mechanism and time course of spaceflight-induced orthostatic intolerance and to develop effective countermeasures for improving post-flight cardiovascular performance.  Where feasible, these studies are aided by theoretical analyses using mathematical modeling and computer simulation of physiological systems.  This paper is concerned with the application of proven models of circulatory and cardiovascular systems in the analysis of chronic cardiovascular changes under weightless conditions.
authors.affiliation: NASA, Life Sciences Division, Washington, DC.
authors.forename: R J
authors.initials: RJ
authors.lastname: White
authors.forename: J I
authors.initials: JI
authors.lastname: Leonard
authors.forename: R S
authors.initials: RS
authors.lastname: Srinivasan
authors.forename: J B
authors.initials: JB
authors.lastname: Charles
mesh_terms: D018493:Cardiovascular Deconditioning / Q000502:physiology*; D003198:Computer Simulation; D005440:Fluid Therapy; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology*; D008150:Lower Body Negative Pressure; D008955:Models, Cardiovascular; D010953:Plasma Volume / Q000502:physiology; D011311:Pressoreceptors / Q000502:physiology; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects; D018544:Weightlessness Countermeasures; D018474:Weightlessness Simulation