title: Maximum of the weighted Kaplan-Meier tests with application to cancer prevention and screening trials.
abstract: A class of maximum weighted Kaplan-Meier test statistics is described where the weight functions are chosen from a family of smooth functions. The investigated test statistic is robust and sensitive to a variety of alternatives that are often observed in cancer prevention and screening trials. A simulation study is performed to compare the size and power properties between the proposed test statistics and some existing ones. We illustrate the procedure using data from a clinical trial of a breast cancer screening program.
authors.affiliation: Department of Biostatistics, M. D. Anderson Cancer Center, University of Texas, Houston 77030, USA. yushen@odin.mdacc.tmc.edu
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: J
authors.initials: J
authors.lastname: Cai
mesh_terms: D001699:Biometry; D001943:Breast Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008403:Mass Screening; D015233:Models, Statistical; D009369:Neoplasms / Q000517:prevention & control*; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D016019:Survival Analysis