Synthesis of 2',3'-dideoxy-2',3'-didehydro nucleosides via a serendipitous route.
This paper describes a "green" synthesis of 2',3'-unsaturated 2',3'-dideoxynucleosides via an electrochemical reaction. Using this approach d4T, d4U, ddA and ddI can be synthesized in high yields.
Guo
Z
Z
Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, California 92008, USA.
Sanghvi
Y S
YS
Brammer
L E
LE
Hudlicky
T
T
D015224:Dideoxynucleosides / Q000138:chemical synthesis*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013936:Thymidine / Q000138:chemical synthesis
D015224:Dideoxynucleosides; D011741:Pyrimidine Nucleosides; D013936:Thymidine