Regulation of PAI-1 expression by genetic polymorphisms. Impact on atherogenesis.
Increased expression of plasminogen activator inhibitor type 1 (PAI-1) is now considered as an independent risk factor for cardiovascular disease. Numerous biochemical factors have been found to regulate the expression of PAI-1 gene and the synthesis of PAI-1 protein. In the recent past, polymorphisms in the PAI-1 gene have been identified and their impact on PAI-1 expression has been characterized. This article will review the current knowledge of these PAI-1 gene polymorphisms (in cell culture epidemiological, and clinical studies) and their role in the development of cardiovascular disease.
Nordt
T K
TK
Department of Cardiology, University of Freiburg, Freiburg, Germany. nordt@mm31.ukl.uni-freiburg.de
Lohrmann
J
J
Bode
C
C
D002318:Cardiovascular Diseases / Q000209:etiology* / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D011110:Polymorphism, Genetic / Q000502:physiology*; D015842:Serine Proteinase Inhibitors / Q000096:biosynthesis* / Q000235:genetics
D017395:Plasminogen Activator Inhibitor 1; D015842:Serine Proteinase Inhibitors