SNF4435C and D, novel immunosuppressants produced by a strain of Streptomyces spectabilis. I. Taxonomy, fermentation, isolation and biological activities.
SNF4435C and D, novel nitrophenyl pyrones, have been isolated from the culture broth of an actinomycete strain SNF4435. The strain was identified as Streptomyces spectabilis from its morphological and cultural characteristics. SNF4435C and D showed a potent immunosuppressive activity in vitro and selectively suppressed B-cell proliferation induced by LPS versus T-cell proliferation induced by Con A.
Kurosawa
K
K
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan. kurosawa@snowbrand.co.jp
Takahashi
K
K
Tsuda
E
E
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D005285:Fermentation; D018922:HL-60 Cells; D006801:Humans; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D020014:K562 Cells; D007624:KB Cells; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D009574:Nitro Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000378:metabolism
D007166:Immunosuppressive Agents; D009574:Nitro Compounds; D011753:Pyrones; C435067:SNF 4435C; C435066:SNF 4435D