Synthesis and evaluation of antiviral activity of higher homologues of xylo-carbocyclic nucleosides.
New carbocyclic nucleosides with purine (compounds 3a and 3b), and 8-azapurine (compounds 3c and 3d) as base were prepared and assayed for in vitro activity.
Caamaño
O
O
Depto. Química Orgánica, Universidad de Santiago, E-15706, Santiago de Compostela, Spain.
Figueira
M J
MJ
Fernández
F
F
García
M D
MD
Nieto
M I
MI
De Clercq
E
E
Balzarini
J
J
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008968:Molecular Conformation; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011687:Purines / Q000138:chemical synthesis / Q000494:pharmacology; D014994:Xylose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011684:Purine Nucleosides; D011687:Purines; C015008:triazolopyrimidinone; D014994:Xylose