title: The effect of kidney transplant on cardiac function: an echocardiographic perspective.
abstract: Kidney transplant (KT) resolves many of the cardiac abnormalities associated with chronic kidney failure (CKF). This study analyzed cardiac alterations of kidney failure and their modification with transplant. Thirteen patients in CKF underwent conventional echocardiograms, dobutamine stress echocardiograms, and injection of contrast to examine perfusion before KT and 3 months after transplant. Nine patients had evidence of left ventricular hypertrophy and six had evidence of diastolic dysfunction. Wall thickness, left ventricular mass, and mass index diminished after KT; only two patients continued to manifest hypertrophy. Left ventricular systolic diameters and volumes diminished at 3 months, and diastolic diameters after 4 months. Left ventricular fractional shortening and ejection fraction increased 3 months after transplant. At the end of the study, only two patients continued to show diastolic dysfunction. Dobutamine echocardiograms showed no segmental wall-movement abnormalities. Myocardial perfusion was normal before and after transplant. The results suggest that KT diminishes hypertrophy and improves left ventricular systolic and diastolic function. Echocardiography provides valuable information for detection and follow-up of cardiac abnormalities in patients with kidney disease. Evaluation of segmental wall movement and myocardial perfusion aid in demonstrating that our studied patients with CKF had no indirect signs of coronary artery disease.
authors.affiliation: Department of Echocardiography, Instituto Nacional de Cardiología Ignacio Chávez, JuanBadiano No. 1, Colonia Sección XVI, Tlalpan, México, D.F., Mexico.
authors.forename: G
authors.initials: G
authors.lastname: Sahagún-Sánchez
authors.forename: N
authors.initials: N
authors.lastname: Espinola-Zavaleta
authors.forename: M
authors.initials: M
authors.lastname: Lafragua-Contreras
authors.forename: P Y
authors.initials: PY
authors.lastname: Chávez
authors.forename: N
authors.initials: N
authors.lastname: Gómez-Núñez
authors.forename: C
authors.initials: C
authors.lastname: Keirns
authors.forename: A
authors.initials: A
authors.lastname: Romero-Cardenas
authors.forename: H
authors.initials: H
authors.lastname: Pérez-Grovas
authors.forename: J H
authors.initials: JH
authors.lastname: Acosta
authors.forename: J
authors.initials: J
authors.lastname: Vargas-Barrón
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000175:diagnosis; D004280:Dobutamine; D004452:Echocardiography; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000150:complications; D006321:Heart / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D016030:Kidney Transplantation / Q000000981:diagnostic imaging; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D011446:Prospective Studies; D006435:Renal Dialysis; D013997:Time Factors; D016276:Ventricular Function / Q000502:physiology
chemical_list: D004280:Dobutamine