title: Bileaflet aortic valve prosthesis pivot geometry influences platelet secretion and anionic phospholipid exposure.
abstract: The clinical histories of the Medtronic Parallel (MP) and St. Jude Medical (SJM) Standard valves suggest pivot geometry influences the thrombogenic characteristics of bileaflet prostheses. This work studied the effects of various pivot geometries on markers of platelet damage in a controlled, in vitro apparatus. The Medtronic Parallel valve, two St. Jude Medical valves, and two demonstration prostheses were used to study the effects of bileaflet pivot design, gap width, and size on platelet secretion and anionic phospholipid expression during leakage flow. A centrifugal pump was used to drive blood through a circuit containing a bileaflet prosthesis. Samples were taken at set time intervals after the start of the pump. These samples were analyzed by cell counting, flow cytometry, and enzyme-linked immunosorbant assay. No significant differences were observed in platelet secretion or anionic phospholipid expression between experiments with the SJM 27 Standard regular leaker, the SJM 20 regular leaker, and the MP 27 valves. Significant differences in platelet secretion and anionic phospholipid expression were observed between a SJM 27 Standard regular leaker and a SJM 27 high leaker valve. These studies suggest that leakage gap width within bileaflet valve pivots has a significant effect on platelet damage initiated by leakage flow.
authors.affiliation: Department of Chemical Engineering, Georgia Institute of Technology, Atlanta, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Travis
authors.forename: U M
authors.initials: UM
authors.lastname: Marzec
authors.forename: H L
authors.initials: HL
authors.lastname: Leo
authors.forename: T
authors.initials: T
authors.lastname: Momin
authors.forename: C
authors.initials: C
authors.lastname: Sanders
authors.forename: S R
authors.initials: SR
authors.lastname: Hanson
authors.forename: A P
authors.initials: AP
authors.lastname: Yoganathan
mesh_terms: D000838:Anions; D001021:Aortic Valve; D001698:Biomedical Engineering; D001792:Blood Platelets / Q000502:physiology*; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006439:Hemodynamics; D006801:Humans; D066298:In Vitro Techniques; D010743:Phospholipids / Q000097:blood* / Q000737:chemistry; D010978:Platelet Factor 4 / Q000378:metabolism; D011474:Prosthesis Design; D013927:Thrombosis / Q000209:etiology
chemical_list: D000838:Anions; D010743:Phospholipids; D010978:Platelet Factor 4