title: Mutation induction in mammalian cells by very heavy ions.
abstract: V79 Chinese hamster cells were exposed to heavy ions (O to U) and assayed for mutants at the HGPRT-locus by incubation in selective medium containing 6-thioguanine.  The LET ranged from 300 to 18000 keV/micrometer.  Mutants could be recovered from all particle radiation but the effectivity per deposited energy decreased with atomic numbers greater than 8.  The results are discussed with regard to fundamental processes of cell reactions to very heavy ions and with respect to possible implications for hazard estimations.
authors.affiliation: Strahlenzentrum der Justus-Liebig-Universität, Giessen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Kranert
authors.forename: U
authors.initials: U
authors.lastname: Stoll
authors.forename: E
authors.initials: E
authors.lastname: Schneider
authors.forename: J
authors.initials: J
authors.lastname: Kiefer
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D003359:Cosmic Radiation; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D004602:Elements; D007477:Ions; D018499:Linear Energy Transfer; D008954:Models, Biological; D009154:Mutation; D010315:Particle Accelerators; D011853:Radiobiology / Q000379:methods; D012062:Relative Biological Effectiveness
chemical_list: D004602:Elements; D007477:Ions