Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats.
BACKGROUND
Rats reared in social isolation from weaning show prepulse inhibition (PPI) deficits which are thought to model the sensorimotor gating deficits seen in schizophrenia and other psychiatric disorders. However, recent studies have questioned the robustness of this paradigm.


OBJECTIVE
The existence of a substantial dataset generated over 4 years in our laboratory has allowed the investigation of the robustness and reliability of the procedure under a variety of environmental conditions. The effects of atypical antipsychotics (clozapine, olanzapine and risperidone) under different experimental conditions are also reported.


METHODS
At weaning, Hooded Lister pups were singly (isolates) or group (n=5) housed (grouped). Eight weeks later, the startle and PPI response of isolates and grouped rats was investigated using conditions of fixed inter-stimulus interval (ISI) (pulse=110 dB/50 ms; prepulse=80 dB/30 ms; ISI=100 ms) or variable
Cilia
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J
Neuroscience Research, GlaxoSmithKline, Harlow, Essex, UK. jackie_cilia-1@sbphrd.com
Reavill
C
C
Hagan
J J
JJ
Jones
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D000161:Acoustic Stimulation; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D003024:Clozapine / Q000494:pharmacology; D003213:Conditioning, Psychological; D006234:Handling, Psychological; D008297:Male; D008960:Models, Psychological; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects* / Q000502:physiology*; D018967:Risperidone / Q000494:pharmacology; D012934:Social Isolation / Q000523:psychology*; D012951:Socialization
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D003024:Clozapine; D018967:Risperidone; D000077152:Olanzapine