title: [Hepatitis B markers in southern Altaĭ inhabitants of the village of Mendur-Sokkon (the Republic of Altaĭ). HBsAg subtyping in hepatitis B virus isolates with monoclonal antibodies].
abstract: Blood samples taken from 231 native inhabitants of the village of Mendur-Sokkon located in the Republic of Altai (South-Western Siberia, Russia) were tested for the presence of virus hepatitis B (HBV) markers. 31 samples (13.4%) were found to contain HBsAg, 111 samples (48.05%) were found to contain total anti-HBc antibodies, 123 samples (53.24%) were found to contain anti-HBs antibodies and 15 blood samples (6.49%), anti-HBc antibodies without anti-HBs antibodies and HBsAg. The age-dependent distribution of the occurrence of HBV markers among the aboriginal population of the South Altal remained unchanged (69.9 +/- 7.9%) for the last 50 years. The vertical and horizontal routes of HBV transmissions were noted. The data obtained in this study are indicative of a highly endemic character of HBV of the territory of Mendur-Sokkon. HBsAg-positive blood samples were taken for HBsAg subtyping with the use of a panel of monoclonal antibodies. Two subtypes of HBsAg were detected: ayw1-2 and ayw3varB with the occurrence of 92.6% and 7.4%, i.e. distributed in the ratio 25/2.
authors.affiliation: Closed Joint-Stock Company Vector-Best, State Research Center Vector, Koltsovo, Novosibirsk Region, Russia.
authors.forename: I G
authors.initials: IG
authors.lastname: Netesova
authors.forename: P D
authors.initials: PD
authors.lastname: Swenson
authors.forename: L P
authors.initials: LP
authors.lastname: Osipova
authors.forename: N N
authors.initials: NN
authors.lastname: Kiselev
authors.forename: O L
authors.initials: OL
authors.lastname: Posukh
authors.forename: N S
authors.initials: NS
authors.lastname: Cherepanova
authors.forename: M A
authors.initials: MA
authors.lastname: Kazakovtseva
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Kashinskaia
authors.forename: S V
authors.initials: SV
authors.lastname: Netesov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000382:microbiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood* / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012703:Serotyping; D012800:Siberia / Q000453:epidemiology
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D006514:Hepatitis B Surface Antigens