Syntheses and preliminary pharmacological evaluation of the two epimers of the 5-F2t-isoprostane.
The total synthesis of the 5-F2t-isoprostane 1 and its 5-epimer 2 from diacetone-D-glucose is described. We report preliminary data on the vascular properties of these compounds.
Durand
T
T
UMR C.N.R.S. 5074, Université Montpellier 1, Faculté de Pharmacie, 15 Av. C. Flahault, F-34060 Cedex 2, Montpellier, France. froxy@pharma.univ-montp1.fr
Cracowski
J L
JL
Guy
A
A
Rossi
J C
JC
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001671:Biochemistry / Q000379:methods; D066298:In Vitro Techniques; D007536:Isomerism; D028421:Isoprostanes / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000737:chemistry* / Q000494:pharmacology*
D028421:Isoprostanes; D014662:Vasoconstrictor Agents; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid