title: [Acute toxicity of aversectin C : various routes of administration and dosage forms].
abstract: The acute oral, cutaneous, and inhalation toxicity of aversectin C was studied on white unbred rats and mice. The compound was less toxic for rats than for mice, the LD50 for oral administration being 90 and 33 mg/kg, respectively. Aversectin C exhibited a maximum acute toxicity upon the inhalation in rats (LD50 = 40 mg/kg), while a minimum toxicity level was observed for the cutaneous application in rats (1700 mg/kg).
authors.affiliation: FARMBIOMED Research and Production Corporation, ul. Lobachevskogo 14, Moscow, 117415 Russia.
authors.forename: T S
authors.initials: TS
authors.lastname: Novik
authors.forename: R V
authors.initials: RV
authors.lastname: Baru
authors.forename: V A
authors.initials: VA
authors.lastname: Riabova
authors.forename: S I
authors.initials: SI
authors.lastname: Chukina
authors.forename: E B
authors.initials: EB
authors.lastname: Krugliak
authors.forename: V A
authors.initials: VA
authors.lastname: Mosin
authors.forename: V A
authors.initials: VA
authors.lastname: Driniaev
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000633:toxicity*; D004304:Dosage Forms; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010575:Pesticides / Q000633:toxicity*; D051381:Rats; D023382:Toxicity Tests, Acute
chemical_list: D000977:Antiparasitic Agents; D004304:Dosage Forms; D010575:Pesticides; D007559:Ivermectin; C019264:avermectin