title: Computer simulation of fibrillation threshold measurements and electrophysiologic testing procedures.
abstract: A finite element model of cardiac conduction was used to simulate two experimental protocols: 1) fibrillation threshold measurements and 2) clinical electrophysiologic (EP) testing  procedures. The model consisted of a cylindrical lattice whose properties were determined by four parameters: element length, conduction velocity, mean refractory period, and standard deviation of refractory periods. Different stimulation patterns were applied to the lattice under a given set of lattice parameter values and the response of the model was observed through a simulated electrocardiogram. The studies confirm that the model can account for observations made in experimental fibrillation threshold measurements and in clinical EP testing protocols.
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA.
authors.forename: M P
authors.initials: MP
authors.lastname: Grumbach
authors.forename: B E
authors.initials: BE
authors.lastname: Saxberg
authors.forename: R J
authors.initials: RJ
authors.lastname: Cohen
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004562:Electrocardiography / Q000379:methods*; D004594:Electrophysiology; D006329:Heart Conduction System / Q000502:physiology* / Q000503:physiopathology; D008955:Models, Cardiovascular; D014693:Ventricular Fibrillation