title: Topical tacrolimus in the treatment of bovine collagen hypersensitivity.
abstract: BACKGROUND
  Soft tissue augmentation with bovine collagen is a common and safe aesthetic procedure. Despite adequate pretreatment testing, allergic reactions can develop. The medical literature provides little guidance to the clinician in the management of bovine collagen hypersensitivity.
  
  
  OBJECTIVE
  We describe a case of bovine collagen allergy treated with 0.1% topical tacrolimus and corticosteroids.
  
  
  METHODS
  Clinical evaluation and management of a patient with bovine collagen hypersensitivity.
  
  
  RESULTS
  Our patient responded to combined therapy with oral corticosteroids and topical tacrolimus.
  
  
  CONCLUSIONS
  Topical tacrolimus may be a useful first-line or adjuvant therapy in the management of bovine collagen allergic reactions. Further clinical experience with its use for bovine collagen hypersensitivity is required to determine its true efficacy in this condition.
authors.affiliation: Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Moody
authors.forename: R D
authors.initials: RD
authors.lastname: Sengelmann
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002417:Cattle; D003094:Collagen / Q000008:administration & dosage / Q000276:immunology*; D003357:Cosmetic Techniques; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy* / Q000276:immunology; D004359:Drug Therapy, Combination; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000188:drug therapy* / Q000276:immunology; D007267:Injections; D007428:Intradermal Tests; D011241:Prednisone / Q000008:administration & dosage; D019233:Retreatment; D016559:Tacrolimus / Q000008:administration & dosage*
chemical_list: D003094:Collagen; D011241:Prednisone; D016559:Tacrolimus