title: Stereospecific synthesis of trans-arachidonic acids.
abstract: An effective synthesis is described for the preparation of all four mono trans isomers of arachidonic acid via deoxidation of epoxide precursors with lithium diphenylphosphide and quaternization with methyl iodide.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: U M
authors.initials: UM
authors.lastname: Krishna
authors.forename: M M
authors.initials: MM
authors.lastname: Reddy
authors.forename: J
authors.initials: J
authors.lastname: Xia
authors.forename: J R
authors.initials: JR
authors.lastname: Falck
authors.forename: M
authors.initials: M
authors.lastname: Balazy
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D016718:Arachidonic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D001671:Biochemistry / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: D016718:Arachidonic Acid; C046783:11,12-epoxy-5,8,14-eicosatrienoic acid; C040776:5,6-epoxy-8,11,14-eicosatrienoic acid; C050715:8,9-epoxyeicosatrienoic acid; C046782:14,15-epoxy-5,8,11-eicosatrienoic acid; D015126:8,11,14-Eicosatrienoic Acid