title: [Measuring isokinetic force in patients with gonarthrosis before and after hyaluronic acid therapy].
abstract: OBJECTIVE
  In the study we evaluated the effectiveness of intraarticular injected hyaluronic acid (Hyalart) with regard to the changes in the parameters maximal isokinetic muscle strength, total work, pain at rest, and pain under toad.
  
  
  METHODS
  We examined 43 patients with osteoarthritis in both knee joints (Kellgren II or II according to X-ray) in right/left comparison. We used the isokinetic system Cybex 600 for measuring the maximal isokinetic muscle strength and the total work. We used the visual analog scale for the pain. The evaluated parameters were measured before and after a 5-week treatment phase with 5 intraarticular injections (one injection per week with 20 mg hyaluronic acid).
  
  
  RESULTS
  In knees treated with hyaluronic acid the mean peak torque of the knee extensor was 57 +/- 26.15/32 +/- 19.63 Nm vs. 77.17 +/- 32.54/47.83 +/- 21.43 Nm after (p < 0.01), the mean peak torque of the knee flexor was 40.44 +/- 21.58/22.89 +/- 16.64 Nm vs. 53.55 +/- 24.26/34.05 +/- 17.37 Nm after treatment (p < 0.01) at the angular velocities of 60 degrees/s and 180 degrees/s. Significant differences (p > 0.01) between treated and untreated knee were found for total work of the extensor and flexor of the knee. The pain at rest decreased from 3.83 +/- 1.72 cm to 1.36 +/- 1.42 cm and the pain under load decreased from 7.57 +/- 1.34 cm to 3.75 +/- 1.32 cm in the treated knee group (p < 0.01).
  
  
  CONCLUSIONS
  The intraarticular injection of hyaluronic acid is effective and safe in the treatment of patients with gonarthrosis. The treatment resulted in a functional improvement of the knee joint and had a good pain lowering effect in patients suffering from gonarthrosis.
authors.affiliation: Orthopädische Universitätsklink, RWTH Aachen. Miltner.Heuter@t-online.de
authors.forename: O
authors.initials: O
authors.lastname: Miltner
authors.forename: U
authors.initials: U
authors.lastname: Schneider
authors.forename: C H
authors.initials: CH
authors.lastname: Siebert
authors.forename: D C
authors.initials: DC
authors.lastname: Wirtz
authors.forename: F U
authors.initials: FU
authors.lastname: Niethard
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D007537:Isometric Contraction / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000503:physiopathology / Q000534:rehabilitation*; D010147:Pain Measurement; D016896:Treatment Outcome; D016474:Weight-Bearing / Q000502:physiology
chemical_list: D006820:Hyaluronic Acid