Correlation with redox potentials and inhibitory effects on Epstein-Barr virus activation of azaanthraquinones.
The redox potentials have been determined for nine azaanthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the azaanthraquinones on Epstein-Barr virus early antigen (EBV-EA) activation. It has further been shown that the correlation can be made better by introducing an electronic property, i.e., the atomic charge at O11 as an additional parameter.
Koyama
J
J
Kobe Pharmaceutical University, Higashinada, Japan. j-koyama@kobepharma-u.ac.jp
Morita
I
I
Tagahara
K
K
Osakai
T
T
Hotta
H
H
Yang
M X
MX
Mukainaka
T
T
Nishino
H
H
Tokuda
H
H
D000880:Anthraquinones / Q000737:chemistry*; D000998:Antiviral Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000737:chemistry*; D002478:Cells, Cultured; D004563:Electrochemistry; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D013055:Spectrophotometry, Infrared; D014775:Virus Activation / Q000187:drug effects*
D000880:Anthraquinones; D000998:Antiviral Agents; D001372:Aza Compounds; D007202:Indicators and Reagents