[Mechanisms of glomerular autoimmunity and a strategy for immunomodulation in glomerular nephritis].
The article is a review of the published foreign literature concerning mechanisms of self-defence of the renal glomerulus and ways for drug correction thereof. The glomerulus self-defence intra- and extracell factors are described in detail. Novel drugs having been approbated in the experiment and in clinical settings intended to slow down the rate of progression of affections of the kidneys are mentioned together with ways for prevention thereof.
Kolesnyk
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MO
Lapchyns'ka
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D000276:Adjuvants, Immunologic / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015551:Autoimmunity / Q000187:drug effects / Q000276:immunology*; D002986:Clinical Trials as Topic; D003165:Complement System Proteins / Q000276:immunology; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000276:immunology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000276:immunology; D015777:Eicosanoids / Q000276:immunology; D015316:Genetic Therapy / Q000379:methods; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D006133:Growth Substances / Q000276:immunology; D006360:Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology* / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors / Q000276:immunology; D011480:Protease Inhibitors / Q000276:immunology
D000276:Adjuvants, Immunologic; D000975:Antioxidants; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D016207:Cytokines; D015777:Eicosanoids; D006133:Growth Substances; D006360:Heat-Shock Proteins; D011480:Protease Inhibitors; D003165:Complement System Proteins; D010749:Phosphoprotein Phosphatases