New diterpenes from the Caribbean sponge Epipolasis reiswigi.
Two diterpenes, epipolone (1) and epipolol (3), produced by terpenoid pathways leading to a tricarbocyclic structure with an irregular "head to tail" isoprene configuration, have been isolated from the Caribbean marine sponge Epipolasis reiswigi collected in Puerto Rico. The structures of 1 and 3 were elucidated largely by 1D and 2D NMR methods and chemical conversion.
Rodríguez
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Department of Chemistry, University of Puerto Rico, P.O. Box 23346, San Juan, Puerto Rico 00931-3346. arodrig@goliath.cnnet.clu.edu
Vera
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D000818:Animals; D001685:Biological Factors / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D017489:CDC28 Protein Kinase, S cerevisiae / Q000187:drug effects; D017691:Caribbean Region; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*
D001685:Biological Factors; D004224:Diterpenes; D017489:CDC28 Protein Kinase, S cerevisiae