title: Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.
abstract: Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.
authors.affiliation: Department of Haematology, City Hospital Trust, Dudley Road, Birmingham B18 7QH, UK. Sukhjinder.Marwah@cityhospbham.wmids.nhs.uk
authors.forename: S S
authors.initials: SS
authors.lastname: Marwah
authors.forename: D
authors.initials: D
authors.lastname: Wheelwright
authors.forename: A D
authors.initials: AD
authors.lastname: Blann
authors.forename: C
authors.initials: C
authors.lastname: Rea
authors.forename: R
authors.initials: R
authors.lastname: Beresford
authors.forename: J D
authors.initials: JD
authors.lastname: Phillips
authors.forename: J
authors.initials: J
authors.lastname: Wright
authors.forename: D
authors.initials: D
authors.lastname: Bareford
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000628:therapy; D000975:Antioxidants / Q000032:analysis*; D001803:Blood Transfusion; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D018709:Statistics, Nonparametric; D014168:Transferrin / Q000032:analysis; D014810:Vitamin E / Q000097:blood*
chemical_list: D000975:Antioxidants; D014168:Transferrin; D014810:Vitamin E; D007501:Iron