title: Symptomatic adrenal insufficiency during inhaled corticosteroid treatment.
abstract: Symptomatic adrenal insufficiency, presenting as hypoglycaemia or poor weight gain, may occur on withdrawal of corticosteroid treatment but has not previously been reported during inhaled corticosteroid treatment. This case series illustrates the occurrence of clinically significant adrenal insufficiency in asthmatic children while patients were on inhaled corticosteroid treatment and the unexpected modes of presentation. General practitioners and paediatricians need to be aware that this unusual but acute serious complication may occur in patients treated with inhaled corticosteroids.
authors.affiliation: Department of Child Health, University of Manchester, Booth Hall Childrens Hospital, Manchester M9 7AA, UK. lp@man.ac.uk
authors.forename: L
authors.initials: L
authors.lastname: Patel
authors.forename: J K
authors.initials: JK
authors.lastname: Wales
authors.forename: M S
authors.initials: MS
authors.lastname: Kibirige
authors.forename: A A
authors.initials: AA
authors.lastname: Massarano
authors.forename: J M
authors.initials: JM
authors.lastname: Couriel
authors.forename: P E
authors.initials: PE
authors.lastname: Clayton
mesh_terms: D000280:Administration, Inhalation; D000287:Administration, Topical; D000309:Adrenal Insufficiency / Q000139:chemically induced* / Q000175:diagnosis; D000324:Adrenocorticotropic Hormone; D000730:Androstadienes / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D001507:Beclomethasone / Q000009:adverse effects; D019819:Budesonide / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D000068298:Fluticasone; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D008297:Male
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D019819:Budesonide; D000324:Adrenocorticotropic Hormone; D000068298:Fluticasone; D001507:Beclomethasone; D006854:Hydrocortisone