[Disorders of blood rheology in Walker's carcinosarcoma-256 and in cyclophosphamide treatment of rats].
Tumor process development in rats inoculated with cellular suspension of transplantable Walker's carcinosarcoma-256 involved enhanced thickening of blood on day 7. Treatment with 20 mg/kg cyclophosphamide, thrice a day, every other day, retarded tumor process and brought hemorheologic indices further down, at the same time. Similar treatment of intact rats with cyclophosphamide caused hemorheologic disorders too.
Plotnikov
M B
MB
Research Institute of Pharmacology, Russian Academy of Medical Sciences, Siberian Branch, Tomsk.
Maslov
M Iu
MIu
Aliev
O I
OI
Vasil'ev
A S
AS
Zueva
E P
EP
Krylova
S G
SG
Shilova
N V
NV
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D002279:Carcinoma 256, Walker / Q000097:blood* / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D018056:Hemorheology / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide