title: Synthesis and biophysical studies of oligonucleotides containing hydroxamate linkages.
abstract: Novel thymidine dimers containing hydroxamate linkages were synthesized, incorporated into oligonucleotide sequences and studied their hybridization properties against complementary DNA and RNA targets.
authors.affiliation: Medicinal Chemistry Division, ICN Pharmaceuticals, Inc., 3300 Hyland Avenue, Costa Mesa, California 92626, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Ramasamy
authors.forename: V
authors.initials: V
authors.lastname: Stoisavljevic
authors.forename: J Y
authors.initials: JY
authors.lastname: Lau
mesh_terms: D004247:DNA / Q000737:chemistry; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D011740:Pyrimidine Dimers / Q000138:chemical synthesis / Q000737:chemistry; D011742:Pyrimidine Nucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D013936:Thymidine / Q000031:analogs & derivatives
chemical_list: D006877:Hydroxamic Acids; D009841:Oligonucleotides; D011740:Pyrimidine Dimers; D011742:Pyrimidine Nucleotides; D012313:RNA; D004247:DNA; D013936:Thymidine