title: [Changes of blood circulation, muscle and skeletal systems in 30 d tail-suspended [correction of tail-suspented] rats].
abstract: OBJECTIVE
  To confirm the tail-suspended rat model for the study of countermeasures against weightlessness.
  
  
  METHODS
  The changes of blood circulation, muscle and skeletal systems in control group rats (n = 15) and 30 d tail-suspended rats (n = 15) were compared.
  
  
  RESULTS
  Compared with the control group, the hemorrheology and erythrocyte deformability decreased significantly, muscle-fiber atrophy, muscle contraction function decreased, the type I muscle fibers transformed to the type II muscle fibers, bone-mineral content of L3 and load capacity of femur declined, bone metabolism changed in the suspended rats.
  
  
  CONCLUSIONS
  The tail-suspended rat is a suitable animal model for the study of countermeasures against weightlessness.
authors.affiliation: Institute of Space Medico-Engineering, Beijing, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Shen
authors.forename: W
authors.initials: W
authors.lastname: Cui
authors.forename: Y L
authors.initials: YL
authors.lastname: Ma
authors.forename: Q
authors.initials: Q
authors.lastname: Dong
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.forename: G H
authors.initials: GH
authors.lastname: Yang
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001775:Blood Circulation / Q000502:physiology*; D001809:Blood Viscosity; D015519:Bone Density; D002118:Calcium / Q000097:blood; D004907:Erythrocyte Deformability; D005069:Evaluation Studies as Topic; D019417:Hindlimb Suspension / Q000009:adverse effects* / Q000502:physiology; D018656:Muscle Fibers, Fast-Twitch / Q000473:pathology / Q000502:physiology; D018657:Muscle Fibers, Slow-Twitch / Q000473:pathology / Q000502:physiology; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology; D009133:Muscular Atrophy / Q000209:etiology / Q000473:pathology; D009142:Musculoskeletal Physiological Phenomena; D051381:Rats; D018474:Weightlessness Simulation / Q000379:methods*
chemical_list: D002118:Calcium