title: Construction of a physical model of the human carotid artery based upon in vivo magnetic resonance images.
abstract: A method is described for construction of an in vitro flow model based on in vivo measurements of the lumen geometry of the human carotid bifurcation. A large-scale physical model of the vessel lumen was constructed using fused deposition modeling (a rapid prototyping technique) based on magnetic resonance (MR) images of the carotid bifurcation acquired in a healthy volunteer. The lumen negative was then used to construct a flow model for experimental studies that examined the hemodynamic environment of subject-specific geometry and flow conditions. The physical model also supplements physician insight into the three-dimensional geometry of the arterial segment, complementing the two-dimensional images obtained by MR. Study of the specific geometry and flow conditions in patients with vascular disease may contribute to our understanding of the relationship between their hemodvnamic environment and conditions that lead to the development and progression of arterial disease.
authors.affiliation: College of Medicine, The University of Illinois at Chicago 60607, USA.
authors.forename: R V
authors.initials: RV
authors.lastname: Yedavalli
authors.forename: F
authors.initials: F
authors.lastname: Loth
authors.forename: A
authors.initials: A
authors.lastname: Yardimci
authors.forename: W F
authors.initials: WF
authors.lastname: Pritchard
authors.forename: J N
authors.initials: JN
authors.lastname: Oshinski
authors.forename: L
authors.initials: L
authors.lastname: Sadler
authors.forename: F
authors.initials: F
authors.lastname: Charbel
authors.forename: N
authors.initials: N
authors.lastname: Alperin
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D002339:Carotid Arteries / Q000033:anatomy & histology* / Q000502:physiology*; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging; D008297:Male; D008955:Models, Cardiovascular