title: New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives.
abstract: Readily derived from D-glucose, 5-[(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methyl-3-furoic esters and amides are selective and competitive inhibitors (K(i)> or = 3 microM) of alpha-L-fucosidase from bovine epididymis and from human placenta.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, E-41071, Sevilla, Spain. pierre.vogel@ico.unil.ch
authors.forename: I
authors.initials: I
authors.lastname: Robina
authors.forename: A J
authors.initials: AJ
authors.lastname: Moreno-Vargas
authors.forename: J G
authors.initials: JG
authors.lastname: Fernández-Bolaños
authors.forename: J
authors.initials: J
authors.lastname: Fuentes
authors.forename: R
authors.initials: R
authors.lastname: Demange
authors.forename: P
authors.initials: P
authors.lastname: Vogel
mesh_terms: D000818:Animals; D002417:Cattle; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D004822:Epididymis / Q000201:enzymology; D005260:Female; D005663:Furans / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008297:Male; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D005644:alpha-L-Fucosidase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D005663:Furans; D005644:alpha-L-Fucosidase