TCR usage in naive and committed alloreactive cells: implications for the understanding of TCR biases in transplantation.
The direct pathway of allorecognition is involved in acute allograft rejection and is characterised by TCR-mediated recognition of the MHC framework; this is thought to occur in a peptide-dependent but not peptide-specific manner. In contrast, the indirect pathway is restricted to the recipient's own MHC molecules and prevails in chronic rejection. In this pathway, the peptide has a major influence on the TCR recognition and selects alloreactive T cells with altered TCR Vbeta usage. However, qualitative analysis of Vbeta usage alone might limit our understanding of alloreactivity. The advantages of a combined quantitative assessment of Vbeta mRNA usage are discussed.
Guillet
M
M
Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 437, Immunointervention dans les Allo- et les Xéno-transplantations, 30 Boulevard Jean Monnet, 44093 Nantes 01, Cedex, France.
Sebille
F
F
Soulillou
J
J
D000818:Animals; D006801:Humans; D007399:Interphase / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000378:metabolism*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology / Q000378:metabolism; D014181:Transplantation Immunology / Q000276:immunology*
D007519:Isoantigens; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta