[Effect of the novel taurine derivative on various parameters of metabolism on experimental myocardial infarction].
The effects of TAU-5, a new N-phenylalkyl derivative of taurine, on the metabolic changes in heart were studied in rats with experimental myocardial infarction. The new drug exhibits a pronounced antiischemic effect related to recovery of the activity of enzymes involved in the energy exchange, decrease in the rate of lipid peroxidation, and normalization of the function of enzymes responsible for the antioxidant activity. The results of the pathomorphologic analysis and data on the state of cardiac metabolism showed that the antiischemic effect of TAU-5 is comparable with that of neoton.
Khnychenko
L K
LK
Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St. Petersburg, 197376 Russia.
Bul'on
V V
VV
Sapronov
N S
NS
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003331:Coronary Vessels; D005978:Glutathione / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D013654:Taurine; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D013385:Succinate Dehydrogenase; D001219:Aspartate Aminotransferases; D005978:Glutathione