title: Diuretic as a means for rapid adaptation to weightlessness.
abstract: In a number of flights, cosmonauts and astronauts have experienced aggravation of their health status and general condition in the initial hours and days in a weightless environment. One of the trigger mechanisms for the onset of these unfavourable conditions at the start of space flight is a redistribution of body fluids and a blood shift towards the head. To ensure controlled hypohydration as a countermeasure to the deleterious effects of 0-g and to investigate the feasibility to control adaptation, six cosmonauts were administered lasix once a day during the first 3 days of a mission. All data of the experiment (correction test, questionnaire, hematocrit) were recorded on a special form in the logbook and transmitted to the control centre for processing. Results showed that the diuretic weakened the sensation of discomfort and improved the cosmonauts' general condition. Objective indices of the correction test indicate an increased work ability of cosmonauts. After hypohydration, circulating plasma volumes in the group were reduced by 6.8 + 1.0% on average.
authors.affiliation: Institute of Biomedical Problems, Moscow, Russia.
authors.forename: V B
authors.initials: VB
authors.lastname: Noskov
authors.forename: A I
authors.initials: AI
authors.lastname: Grigoriev
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D000337:Aerospace Medicine; D004232:Diuretics / Q000627:therapeutic use*; D018495:Fluid Shifts / Q000187:drug effects* / Q000502:physiology; D005665:Furosemide / Q000627:therapeutic use*; D006400:Hematocrit; D006801:Humans; D010953:Plasma Volume / Q000187:drug effects; D013026:Space Flight; D018489:Space Motion Sickness / Q000188:drug therapy / Q000517:prevention & control; D013647:Task Performance and Analysis; D014893:Weightlessness / Q000009:adverse effects*; D018544:Weightlessness Countermeasures
chemical_list: D004232:Diuretics; D005665:Furosemide