Base mutation analysis by a ferrocenyl naphthalene diimide derivative.
An electrochemical DNA sensing technique was developed by using ferrocenyl naphthalene diimide coupled with a probe DNA-immobilized electrode. This technique enabled detection of target DNA quickly and with high sensitivity. Applicability of this technique for single nucleotide polymorphisms (SNPs) analysis was demonstrated by successful analysis of a DNA mismatch on the cancer repression gene p53 with high precision.
Takenaka
S
S
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
Miyahara
H
H
Yamashita
K
K
Takagi
M
M
Kondo
H
H
D004247:DNA / Q000032:analysis* / Q000235:genetics; D004252:DNA Mutational Analysis / Q000379:methods*; D004566:Electrodes; D005296:Ferrous Compounds / Q000737:chemistry*; D016158:Genes, p53 / Q000235:genetics; D007094:Imides / Q000737:chemistry*; D009154:Mutation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D020641:Polymorphism, Single Nucleotide
D005296:Ferrous Compounds; D007094:Imides; D009841:Oligonucleotides; C406363:ferrocenylnaphthalene diimide; D004247:DNA