title: Some acyclic analogues of nucleotides and their template-directed reactions.
abstract: Bismonophosphoimidazolides of acyclic analogues of guanosine IV and adenosine V were synthesized.  They undergo oligomerization in the presence of complementary polynucleotide templates.  Details of their synthesis and their subsequent template- and nontemplate-directed reactions are described, and their possible relevance to the origin of life is discussed.
authors.affiliation: The Salk Institute for Biological Studies, San Diego, California 92138, USA.
authors.forename: M
authors.initials: M
authors.lastname: Tohidi
authors.forename: L E
authors.initials: LE
authors.lastname: Orgel
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives*; D019418:Evolution, Chemical; D019143:Evolution, Molecular; D006151:Guanosine / Q000031:analogs & derivatives*; D007093:Imidazoles / Q000138:chemical synthesis; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D000069497:Origin of Life; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D011119:Polynucleotides / Q000138:chemical synthesis / Q000737:chemistry; D013698:Templates, Genetic
chemical_list: D007093:Imidazoles; D009705:Nucleosides; D009711:Nucleotides; D011108:Polymers; D011119:Polynucleotides; D006151:Guanosine; D000241:Adenosine