Replacement of the Epstein-Barr virus plasmid with the EBER plasmid in Burkitt's lymphoma cells.
Transfection of an Epstein-Barr virus (EBV)-encoded plasmid containing EBER caused a substantial decrease in the level of plasmid containing EBV in Akata and Mutu Burkitt's lymphoma (BL) lines, but failed to do so in other BL lines. The results suggest that EBER could replace the role of EBV, but other EBV products also play a role in the growth of BL.
Maruo
S
S
Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815, Japan.
Nanbo
A
A
Takada
K
K
D002051:Burkitt Lymphoma / Q000473:pathology / Q000821:virology*; D002455:Cell Division; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D010957:Plasmids; D012367:RNA, Viral / Q000235:genetics*; D014162:Transfection; D014407:Tumor Cells, Cultured
C099537:Epstein-Barr virus encoded RNA 1; C106732:Epstein-Barr virus encoded RNA 2; D012367:RNA, Viral