Molecular model for the binary complex of uropepsin and pepstatin.
The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic proteinase from the urine, produced in the form of pepsinogen A in the gastric mucosa. The structure is bilobal, consisting of two predominantly beta-sheet lobes which, as observed in other aspartic proteinases, are related by a pseudo twofold axis. A structural comparison between binary complexes of pepsin:pepstatin and uropepsin:pepstatin is discussed.
de Azevedo
W F
WF
Departamento de Física, IBILCE, UNESP, São José do Rio Preto, SP 15054-000, Brazil.
Canduri
F
F
Fadel
V
V
Teodoro
L G
LG
Hial
V
V
Gomes
R A
RA
D001665:Binding Sites; D010450:Endopeptidases / Q000737:chemistry*; D006801:Humans; D006860:Hydrogen Bonding; D008958:Models, Molecular; D010436:Pepstatins / Q000737:chemistry*; D011487:Protein Conformation; D011786:Quality Control; D013379:Substrate Specificity
D010436:Pepstatins; C014195:Streptomyces pepsin inhibitor; D010450:Endopeptidases; C100308:uropepsin; C031375:pepstatin