[Effect of pefloxacin on immune response].
The influence on cellular immune response of different doses of the pefloxacin was studied in vivo as well as in vitro experiments. The pefloxacin in super bactericidal concentrations (2.0 mg/ml and 0.4 mg/ml) possess pronounced supressing effect the T-lymphocyte proliferation in blast transformation reaction. While in concentration 0.08 mg/ml pefloxacin does not show such activity. The pefloxacin in maximal effective concentration (200 mg/kg) suppressed activity in delayed hypersensitivity skin reaction of intact mice towards sheep erythrocytes on 20.3 percent only.
Artsimovich
N G
NG
Institute of Immunology, Ministry of Health of Russian Federation, Moscow.
Nastoiashchaia
N N
NN
Navashin
P S
PS
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002455:Cell Division; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D015366:Pefloxacin / Q000494:pharmacology*; D012756:Sheep; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
D000890:Anti-Infective Agents; D015366:Pefloxacin