title: [Effect of alpha-tryptophan on conditioning and behavior in rats with experimental pathology of the thyroid gland].
abstract: Effects of L-tryptophan on learning and behavior were studied in male rats with a deficit or excess of thyroid hormones. Learning was assessed in active avoidance paradigm, and behavior was estimated in the "open-field" test. It was found that L-tryptophan restored the capability of thyreoidectomized rats for acquisition and reproduction of the active avoidance reaction and increased the exploratory behavior of these rats in the open-field. In triiodothyronine treated rats, L-tryptophan eliminated a light stimulatory effects of thyroid hormones on the processes of formations and retention of the active avoidance reaction, increased the exploratory activity, but decreased grooming in the open-field.
authors.affiliation: Research Institute for Experimental Medicine, Russian Academy of Medical Sciences, St.-Petersburg.
authors.forename: N S
authors.initials: NS
authors.lastname: Sapronov
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Fedotova
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D006980:Hyperthyroidism / Q000523:psychology*; D007037:Hypothyroidism / Q000523:psychology*; D008297:Male; D051381:Rats; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000494:pharmacology; D014364:Tryptophan / Q000494:pharmacology*
chemical_list: D014284:Triiodothyronine; D014364:Tryptophan