title: Bone and body mass changes during space flight.
abstract: Body mass, calcium and skeletal changes occur in humans who have worked in microgravity. Physiologic changes are seen as early as one week and are still occurring 312 days into space flight. The physiologic changes in bone and mineral metabolism may be among those which limits long duration space flight if an adequate countermeasure is not developed. The purpose of this paper is to summarize what is known about calcium dynamics and bone mineral changes as well as associated changes of body mass induced by space flight. The data reported is from a variety of studies conducted in both actual and simulated space flight.
authors.affiliation: NASA Headquarters, USA.
authors.forename: V
authors.initials: V
authors.lastname: Schneider
authors.forename: V
authors.initials: V
authors.lastname: Oganov
authors.forename: A
authors.initials: A
authors.lastname: LeBlanc
authors.forename: A
authors.initials: A
authors.lastname: Rakmonov
authors.forename: L
authors.initials: L
authors.lastname: Taggart
authors.forename: A
authors.initials: A
authors.lastname: Bakulin
authors.forename: C
authors.initials: C
authors.lastname: Huntoon
authors.forename: A
authors.initials: A
authors.lastname: Grigoriev
authors.forename: L
authors.initials: L
authors.lastname: Varonin
mesh_terms: D000337:Aerospace Medicine; D001510:Bed Rest; D015992:Body Mass Index; D018488:Bone Demineralization, Pathologic / Q000209:etiology / Q000378:metabolism / Q000652:urine; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism* / Q000503:physiopathology; D002111:Calcaneus / Q000378:metabolism; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D006801:Humans; D010758:Phosphorus / Q000378:metabolism / Q000652:urine; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*
chemical_list: D010758:Phosphorus; D002118:Calcium