Cutaneous B cell lymphoma in a Mongolian gerbil (Meriones unguiculatus).
A mass was noticed on the right mandible of an aged male Mongolian gerbil. Because of rapid enlargement of the mass, the animal was euthanized and submitted for pathology. The mass was firm, pink in color, 15 mm in diameter, and tightly adherent to adjacent tissues. Staining with hematoxylin and eosin revealed that the mass was a lymphoid tumor. Neoplastic cells had a large, round, dense nuclei and little cytoplasm. The tumor contained numerous mitotic figures. Immunohistochemical stains showed that the neoplastic cells expressed CD19 and IgM but lacked CD3 and CD5. Flow cytometric analysis showed that the neoplastic cells were positive for B220, IgG, and CD40. We concluded that the tumor was a primary cutaneous B cell lymphoma. In addition, the antibodies we used for the present diagnosis were anti-mouse reagents; therefore, they also were useful for subtyping gerbil lymphoid cells.
Su
Y C
YC
Laboratory Animal Center, College of Medicine, National Taiwan University, No. 1, Sec. 1, Jen-Ai Rd., Taipei, Taiwan, 100, Republic of China.
Wang
M H
MH
Wu
M F
MF
D000818:Animals; D018941:Antigens, CD19 / Q000032:analysis; D005434:Flow Cytometry; D005849:Gerbillinae; D007075:Immunoglobulin M / Q000032:analysis; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008938:Mitosis; D009368:Neoplasm Transplantation; D012376:Rodent Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*
D018941:Antigens, CD19; D007075:Immunoglobulin M