Synthesis and evaluation of alpha-LNA.
Three different synthetic routes to the alpha-configured LNA thymine monomer starting from D-allose or D-arabinose were investigated. The introduction of one or four alpha-LNA monomers into alpha-DNA had a destabilizing effect on the duplexes. However, a fully modified alpha-LNA sequence displayed strong recognition of complementary RNA, but no transition with DNA.
Christensen
N K
NK
Department of Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.
Dalskov
J K
JK
Nielsen
P
P
D001089:Arabinose / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D012313:RNA / Q000737:chemistry; D013941:Thymine / Q000031:analogs & derivatives / Q000737:chemistry
D009841:Oligonucleotides; C002055:allose; D012313:RNA; D004247:DNA; D001089:Arabinose; D005947:Glucose; D013941:Thymine