[Prospects for improvements of pharmacologic radioprotective agents].
For solving the problems of medicamentous prevention and treatment of radiation lesions it seems reasonable to change from the empirical methods of anti-radial agent search to the rational one based on the evaluation of potential capacity of the agents to start some mechanisms of radioprotective effect realization. Several groups of such mechanisms were selected including the universal general biologic connected with ADP-ribosylation and nitrogen oxide metabolism. It is proved that on the base of the chosen approaches it is possible to improve some significant characteristics of radioprotectors and to obtain the polyfunctional radioprotective agents and prescriptions.
Krasil'nikov
I I
II
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D000818:Animals; D015195:Drug Design; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D011837:Radiation-Protective Agents; D000246:Adenosine Diphosphate Ribose; D011064:Poly Adenosine Diphosphate Ribose; D009569:Nitric Oxide