title: Mechanisms of pain.
abstract: Persistent or chronic pain is the primary reason people seek medical care, yet current therapies are either inadequate for certain types of pain or cause intolerable side effects. Recently, pain neurobiologists have identified a number of cellular and molecular processes that lead to the initiation and maintenance of pain. Understanding these underlying mechanisms has given significant promise for the development of more effective, more specific pain therapies in the near future.
authors.affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA. cstucky@mcw.edu
authors.forename: C L
authors.initials: CL
authors.lastname: Stucky
authors.forename: M S
authors.initials: MS
authors.lastname: Gold
authors.forename: X
authors.initials: X
authors.lastname: Zhang
mesh_terms: D006801:Humans; D009020:Morphine / Q000627:therapeutic use; D009473:Neuronal Plasticity / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology*; D011634:Public Health / Q000639:trends; D011955:Receptors, Drug / Q000502:physiology; D012106:Research / Q000639:trends; D015398:Signal Transduction; D050916:TRPV Cation Channels
chemical_list: D011955:Receptors, Drug; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D009020:Morphine