title: Gravity effects on biological systems.
abstract: Theoretical investigations of the membrane-solution interface predict different effects of gravity on vertically and horizontally oriented planar membranes.  Single channel events of gramicidin incorporated into phosphatidylserine planar bilayer membranes were measured in 0.1 M KCl solution, pH 7, at room temperature.  The potential difference across the membrane was set to +/- 70 mV.  The mean channel current was observed to be about 20% higher in horizontally oriented membranes compared to vertical membranes.  This is in good agreement with the theoretical considerations and demonstrates that gravity does affect membrane processes by interaction with the membrane-solution interface which is a ubiquitous structure in biological systems.
authors.affiliation: DLR-Institute for Aerospace Medicine, Köln, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Schatz
authors.forename: R
authors.initials: R
authors.lastname: Reitstetter
authors.forename: W
authors.initials: W
authors.lastname: Briegleb
authors.forename: A
authors.initials: A
authors.lastname: Linke-Hommes
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D006096:Gramicidin / Q000378:metabolism; D006112:Gravitation; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D008051:Lipid Bilayers / Q000378:metabolism; D008564:Membrane Potentials; D008954:Models, Biological; D010718:Phosphatidylserines / Q000378:metabolism
chemical_list: D007473:Ion Channels; D008051:Lipid Bilayers; D010718:Phosphatidylserines; D006096:Gramicidin