title: Oncological results of endoscopic resections of Tis and T1 glottic carcinomas by carbon dioxide laser.
abstract: A cohort of 88 patients with glottic cancer (13 Tis, 75 T1) who underwent endoscopic CO2 laser excision between January 1995 and June 1997 was prospectively studied. The mean follow-up was 43 months (range, 30 to 60 months). The depth and extent of the excision (graded according to the European Laryngological Society Classification, which includes 5 types of resection) were based on the results of a preoperative and intraoperative diagnostic test battery. Five patients died of other diseases, and none of glottic cancer. Of the 12 patients who developed a local recurrence, 5 underwent a second endoscopic procedure, 5 a total laryngectomy, and 1 a supracricoid laryngectomy, and 1 was treated with radiotherapy. The 5-year local control rate with endoscopic surgery alone, according to the Kaplan-Meier method, was 91%. None of the variables (8 related to the tumor and 2 to the treatment) tested in a univariate analysis by the log-rank test was found to have a significant impact on disease-free survival rates. The present study confirmed that endoscopic partial cordectomy for Tis and T1 glottic cancers can be regarded as a valid alternative to radiotherapy in terms of oncological results.
authors.affiliation: Department of Otolaryngology, University of Brescia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Peretti
authors.forename: P
authors.initials: P
authors.lastname: Nicolai
authors.forename: C
authors.initials: C
authors.lastname: Piazza
authors.forename: L O
authors.initials: LO
authors.lastname: Redaelli de Zinis
authors.forename: S
authors.initials: S
authors.lastname: Valentini
authors.forename: A R
authors.initials: AR
authors.lastname: Antonelli
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007828:Laryngoscopy; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome