title: Improved outcome with organs from carbon monoxide poisoned donors for intrathoracic transplantation.
abstract: BACKGROUND
  The success of intrathoracic organ transplantation has lead to a growing imbalance between the demand and supply of donor organs. Accordingly, there has been an expansion in the use of organs from nonconventional donors such as those who died from carbon monoxide poisoning. We describe our experience with 7 patients who were transplanted using organs after fatal carbon monoxide poisoning.
  
  
  METHODS
  A retrospective study of the 1,312 intrathoracic organ transplants between January 1979 and February 2000 was completed. Seven of these transplants (0.5%) were fulfilled with organs retrieved from donors after fatal carbon monoxide poisoning. There were six heart transplants and one single lung transplant. The history of carbon monoxide inhalation was obtained in all of these donors.
  
  
  RESULTS
  Five of 6 patients with heart transplant are alive and well with survival ranging from 68 to 1,879 days (mean, 969 +/- 823 days). One patient (a 29-year-old male) died 12 hours posttransplant caused by donor organ failure. The patient who had a right single lung transplant did well initially after the transplant, but died after 8 months caused by Pneumocystis carinii pneumonia. All those recipients who were transplanted from carbon monoxide poisoned donors and ventilated for more than 36 hours, survived for more than 30 days. Moreover, these donors were assessed and optimized by the Papworth donor management protocol.
  
  
  CONCLUSIONS
  Carbon monoxide poisoned organs can be considered for intrathoracic transplantation. In view of the significant risk of donor organ failure, a cautious approach is still warranted. Ideally, the donor should be hemodynamically stable for at least 36 hours from the time of poisoning and on minimal support. A formal approach of invasive monitoring and active management further improves the chances of successful outcome.
authors.affiliation: Transplant Unit Papworth Hospital, Papworth Everard, Cambridgeshire, United Kingdom. heyman.luckraz@papworth-tr.anglox.nhs.uk
authors.forename: H
authors.initials: H
authors.lastname: Luckraz
authors.forename: S S
authors.initials: SS
authors.lastname: Tsui
authors.forename: J
authors.initials: J
authors.lastname: Parameshwar
authors.forename: J
authors.initials: J
authors.lastname: Wallwork
authors.forename: S R
authors.initials: SR
authors.lastname: Large
mesh_terms: D000328:Adult; D002249:Carbon Monoxide Poisoning; D005260:Female; D016027:Heart Transplantation / Q000401:mortality; D006801:Humans; D016040:Lung Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors