Allergic contact dermatitis from sodium dihydroxycetyl phosphate, a new cosmetic allergen?
Sodium dihydroxycetyl phosphate (trade name Dragophos S 2/918501) was identified as a contact allergen in a herbal moisturizing cream causing severe acute contact dermatitis on the hands and face of a 41-year-old woman. Sodium dihydroxycetyl phosphate is a complex mixture of phosphate esters of dihydroxycetyl alcohol, and subsequent analysis and testing revealed hexadecane-1,2-diol as 1 of the allergenic ingredients. Another possible allergen in the compound appears to be hexadecane-1,2-diol, 2-isopropyl ether.
Lomholt
H
H
Department of Dermatology, Odense University Hospital, DK-5000 Odense C, Denmark.
Rastogi
S C
SC
Andersen
K E
KE
D000328:Adult; D000485:Allergens / Q000009:adverse effects* / Q000032:analysis; D003358:Cosmetics / Q000009:adverse effects* / Q000737:chemistry; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005148:Facial Dermatoses / Q000139:chemically induced; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009943:Organophosphorus Compounds / Q000009:adverse effects* / Q000737:chemistry; D010328:Patch Tests
D000485:Allergens; D003358:Cosmetics; C100378:Dragophos S; D009943:Organophosphorus Compounds