title: Activity of the sympathoadrenal system in cosmonauts during 25-day space flight on station Mir.
abstract: The activity of the sympathoadrenal system in cosmonauts was studied by measuring plasma and urinary catecholamines and their metabolites and conjugates.  The appliance Plasma 02 was used for collecting, processing, and storing blood and urine samples from the cosmonauts during the course of a 25-day flight on board the station Mir.  Plasma and urine concentrations of adrenaline (A), noradrenaline (NA), and dopamine (DA) as well as urinary levels of vanillylmandelic acid (VMA) and homovanillic acid (HVA), and plasma levels of catecholamine sulphates were determined before, during and after the space flight.  Plasma NA levels were slightly elevated on day 9 and plasma A on day 20, whereas plasma DA levels were unchanged.  However, most of the changes were within the normal range of control values.   Sulphates of plasma catecholamines did not change during flight but they were significantly elevated after landing.  Urinary levels of A, NA, DA, VMA, and HVA were comparable with preflight values but were elevated at the different intervals studied after landing.  The results obtained suggest that in the short period of about 9 days of the cosmonaut's stay in space the sympathoadrenal system was slightly activated indicating a mild stressful influence of the initial period of flight.  This short-term space flight compared to long-term flight did not as markedly activate the sympathoadrenal system during the process of re-adaptation to Earth's gravity after landing.  Our data suggest that weightlessness is not a stressful factor activating the sympathoadrenal system but it sensitizes the responsiveness of this system during the re-adaptation period after space flight.
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
authors.forename: R
authors.initials: R
authors.lastname: Kvetnansky
authors.forename: V B
authors.initials: VB
authors.lastname: Noskov
authors.forename: P
authors.initials: P
authors.lastname: Blazicek
authors.forename: C
authors.initials: C
authors.lastname: Gharib
authors.forename: I A
authors.initials: IA
authors.lastname: Popova
authors.forename: G
authors.initials: G
authors.lastname: Gauquelin
authors.forename: L
authors.initials: L
authors.lastname: Macho
authors.forename: A
authors.initials: A
authors.lastname: Guell
authors.forename: A I
authors.initials: AI
authors.lastname: Grigoriev
mesh_terms: D000222:Adaptation, Physiological; D000311:Adrenal Glands / Q000378:metabolism* / Q000502:physiology; D002395:Catecholamines / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004298:Dopamine / Q000097:blood / Q000378:metabolism / Q000652:urine; D004837:Epinephrine / Q000097:blood / Q000378:metabolism / Q000652:urine; D006719:Homovanillic Acid / Q000378:metabolism / Q000652:urine; D006801:Humans; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism / Q000652:urine; D013026:Space Flight; D013312:Stress, Physiological / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000652:urine; D013564:Sympathetic Nervous System / Q000378:metabolism* / Q000502:physiology; D014642:Vanilmandelic Acid / Q000378:metabolism / Q000652:urine; D014893:Weightlessness
chemical_list: D002395:Catecholamines; D014642:Vanilmandelic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine