title: Intracardiac thrombus formation and pulmonary thromboembolism immediately after graft reperfusion in 7 patients undergoing liver transplantation.
abstract: Intravascular and/or intracardiac thrombus formation followed by pulmonary thromboembolism with right ventricular dysfunction immediately after graft reperfusion during orthotopic liver transplantation (OLT) is described in 7 patients. This complication may have been related to excessive activation of the coagulation system by graft reperfusion, which overwhelmed anticoagulation mechanisms and was disproportionate to fibrinolysis. Activation of the coagulation system may be more pronounced in patients who receive less than optimal grafts, require massive transfusion, or have septic complications at the time of OLT. It is unclear whether antifibrinolytic therapy during the anhepatic stage had a role. Transesophageal echocardiography was useful in diagnosing and managing intracardiac thrombus and pulmonary thromboembolism.
authors.affiliation: Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: E
authors.initials: E
authors.lastname: Gologorsky
authors.forename: A M
authors.initials: AM
authors.lastname: De Wolf
authors.forename: V
authors.initials: V
authors.lastname: Scott
authors.forename: S
authors.initials: S
authors.lastname: Aggarwal
authors.forename: M
authors.initials: M
authors.lastname: Dishart
authors.forename: Y
authors.initials: Y
authors.lastname: Kang
mesh_terms: D000328:Adult; D003328:Coronary Thrombosis / Q000209:etiology*; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000209:etiology*; D015427:Reperfusion Injury / Q000150:complications*