title: Solution-phase synthesis of an aminomethyl-substituted biaryl library via sequential amine N-alkylation and Suzuki cross-coupling.
abstract: Described herein is the semiautomated preparation of a 20-member aminomethyl-substituted biaryl library. The two-step solution-phase synthesis was achieved via sequential N-alkylation of various amines with either 3- or 4-bromobenzyl bromide and Suzuki cross-coupling of the resultant aryl bromides with various boronic acids.
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto M3J 1P3, Ontario, Canada.
authors.forename: M G
authors.initials: MG
authors.lastname: Organ
authors.forename: E A
authors.initials: EA
authors.lastname: Arvanitis
authors.forename: C E
authors.initials: CE
authors.lastname: Dixon
authors.forename: D J
authors.initials: DJ
authors.lastname: Lavorato
mesh_terms: D000478:Alkylation; D057911:Angiotensin Receptor Antagonists; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D019808:Losartan / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy
chemical_list: D057911:Angiotensin Receptor Antagonists; D001897:Boronic Acids; D007202:Indicators and Reagents; D019808:Losartan