title: [Characteristics of a target population for preventing house-dust mite allergy in toddlers].
abstract: OBJECTIVE
  To evaluate a recruitment strategy to identify high risk toddlers for a programme of prevention of allergy. For screening, parents were asked to participate in our study by information form and screening questionnaire on the occasion of routine check-up visits of toddlers scheduled between 20 and 48 months of age in four paediatric practices. As a next step, readiness of parents for implementation of preventive measures was confirmed.
  
  
  METHODS
  Inclusion criteria were age between 20 and 48 months and a positive atopic family history (evaluated by 5 questions regarding asthma, allergic rhino-conjunctivitis and atopic dermatitis) of parents or siblings. This was confirmed by sensitization to an environmental allergen (skin prick test (SPT)) in at least one parent. If these inclusion criteria were fulfilled, the toddlers were randomly allocated to the intervention and control group of the prevention programme.
  
  
  RESULTS
  111 of 175 screening questionnaires (63.4 %) were returned. In 76.6 % (n = 85) of these 111 questionnaires a positive atopic family history (mother, father, sibling) was noted. All inclusion criteria were fulfilled by only 43 toddlers (age: median 33.6 months, 5-95 % quantile: 21.6-48 months). Based on the positive screening questionnaire, history of atopy was confirmed by positive SPT in 70.0 % of fathers and 77.8 % of mothers. Despite a negative screening questionnaire, history of atopy was detected by a positive SPT in 11.1 % of mothers and 47.4 % of fathers. Detection of specific IgE against house-dust mite in 9 of 18 serum samples revealed the risk for allergy of the toddlers. A re-evaluation after three months showed that all the elements of the prevention programme as well as the recommendations for the control group had been almost completely accepted by all the families concerned practically without any reservations.
  
  
  CONCLUSIONS
  The recruitment of toddlers with high risk for developing allergy turned out well and could be validated. The prevention programme was readily accepted by the families and thus can be used for a larger study.
authors.affiliation: Universitäts-Kinderklinik Freiburg.
authors.forename: J
authors.initials: J
authors.lastname: Lange
authors.forename: C
authors.initials: C
authors.lastname: Reihle
authors.forename: K
authors.initials: K
authors.lastname: Richter
authors.forename: G
authors.initials: G
authors.lastname: Ihorst
authors.forename: M
authors.initials: M
authors.lastname: Herrmann
authors.forename: H
authors.initials: H
authors.lastname: Schwehn
authors.forename: B
authors.initials: B
authors.lastname: Bosch
authors.forename: J
authors.initials: J
authors.lastname: Forster
authors.forename: J
authors.initials: J
authors.lastname: Kühr
mesh_terms: D039741:Antigens, Dermatophagoides; D002675:Child, Preschool; D004391:Dust / Q000009:adverse effects*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006023:Glycoproteins / Q000009:adverse effects*; D006796:Household Work; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D007428:Intradermal Tests; D008297:Male; D008403:Mass Screening; D010290:Parents / Q000193:education; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D012307:Risk Factors
chemical_list: D039741:Antigens, Dermatophagoides; D004391:Dust; D006023:Glycoproteins; D007073:Immunoglobulin E