title: Pharmacological activities in thermal proteins:  relationships in molecular evolution.
abstract: The model of protobiological events that has been presented in these pages has increasing relevance to pharmacological research.  The thermal proteins that function as key substances in the proteinoid theory have recently been found to prolong the survival of rat forebrain neurons in culture and to stimulate the growth of neurites.  A search for such activity in thermal proteins added to cultures of modern neurons was suggested by the fact that some of the microspheres assembled from proteinoids rich in hydrophobic amino acids themselves generate fibrous outgrowths.
authors.affiliation: Department of Neurology, University of Miami, Florida, USA.
authors.forename: S W
authors.initials: SW
authors.lastname: Fox
authors.forename: F
authors.initials: F
authors.lastname: Hefti
authors.forename: J
authors.initials: J
authors.lastname: Hartikka
authors.forename: E
authors.initials: E
authors.lastname: Junard
authors.forename: A T
authors.initials: AT
authors.lastname: Przybylski
authors.forename: G
authors.initials: G
authors.lastname: Vaughan
mesh_terms: D000596:Amino Acids / Q000032:analysis / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000032:analysis / Q000378:metabolism; D002478:Cells, Cultured; D003470:Culture Media; D019143:Evolution, Molecular; D006358:Hot Temperature; D007930:Leucine / Q000032:analysis / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011108:Polymers / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D014364:Tryptophan / Q000032:analysis / Q000378:metabolism
chemical_list: D000596:Amino Acids; D003470:Culture Media; D011108:Polymers; D001224:Aspartic Acid; D014364:Tryptophan; D007930:Leucine