Actinomyces naeslundii fimbrial protein Orf977 shows similarity to a streptococcal adhesin.
The nucleotide sequence of the chromosomal DNA, upstream of Actinomyces naeslundii T14V fimbrial gene fimA, was determined. One open reading frame (orf977) encoding 977 amino acids was found, preceded by a gene homologous to elongation factor TU. Database searches revealed that Orf977 was homologous to CshA, a Streptococcus gordonii protein involved in cell adhesion. Previous studies had already determined two genes in the type 2 fimbrial gene cluster of A. naeslundii T14V: the structural subunit fimA, and orf365 with unknown function, followed by ribosomal genes. This study completes the type 2 fimbrial gene cluster sequence.
Hoflack
L
L
Department of Pediatric Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Yeung
M K
MK
D000190:Actinomyces / Q000235:genetics*; D018829:Adhesins, Bacterial / Q000737:chemistry / Q000235:genetics*; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D010861:Fimbriae, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics*; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017386:Sequence Homology, Amino Acid; D013298:Streptococcus sanguis / Q000235:genetics
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; C079041:CshA protein, Streptococcus gordonii; D008565:Membrane Proteins; C440222:Orf977 Protein, Actinomyces