Effect of cholinergic agonists on resting membrane potential of earthworm body wall muscle cells.
Carbachol in a concentration of 5x10(-8) mol/liter does not hyperpolarize, and in a concentration of 5x10(-6) mol/liter depolarizes the membrane of somatic muscle cell in earthworm. d-tubocurarine, alpha-bungarotoxin, atropine, and hexamethonium added to the incubation medium did not abolish the carbachol-induced decrease in resting membrane potential. Each of these drugs alone had no effect on resting membrane potential in muscle cells. Presumably, the acetylcholine-sensitive receptor-channel membrane complex in earthworm muscle cell differs from acetylcholine receptor in skeletal muscle fibers and peripheral neurons of vertebrates.
Volkov
E M
EM
Kazan State Medical University. emvolkov@kzn.ru
Nurullin
L F
LF
Frosin
V N
VN
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002038:Bungarotoxins / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology*; D018679:Cholinergic Agonists / Q000494:pharmacology*; D005730:Ganglionic Blockers / Q000494:pharmacology; D018738:Hexamethonium / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects*; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009132:Muscles / Q000166:cytology*; D018733:Nicotinic Antagonists / Q000494:pharmacology; D009835:Oligochaeta; D014403:Tubocurarine / Q000494:pharmacology
D002038:Bungarotoxins; D018679:Cholinergic Agonists; D005730:Ganglionic Blockers; D018727:Muscarinic Antagonists; D018733:Nicotinic Antagonists; D018738:Hexamethonium; D001285:Atropine; D002217:Carbachol; D000109:Acetylcholine; D014403:Tubocurarine