title: The state of human bone tissue during space flight.
abstract: The results of studying the bone tissue of cosmonauts after the flights (4-8 month) have been compared to the data of investigating the healthy individuals during head-down tilt (HDT, 370 days).  Noninvasive methods (computer tomography, gammaphoton absorptiometry) revealed a decrease in the vertebral spongy mineral density or a increase of this parameter by a similar magnitude versus the individual preflight values in some cosmonauts.  During studies of clinical cases of osteoporosis it was shown that the vertebral mineral density ratios and presence or absence of vertebral compression fractures in different age groups are nonequal.
authors.affiliation: Institute for Bio-Medical Problems, Moscow, USSR.
authors.forename: V S
authors.initials: VS
authors.lastname: Oganov
authors.forename: A S
authors.initials: AS
authors.lastname: Rakhmanov
authors.forename: V E
authors.initials: VE
authors.lastname: Novikov
authors.forename: S T
authors.initials: ST
authors.lastname: Zatsepin
authors.forename: S S
authors.initials: SS
authors.lastname: Rodionova
authors.forename: C
authors.initials: C
authors.lastname: Cann
mesh_terms: D015502:Absorptiometry, Photon; D000367:Age Factors; D001510:Bed Rest / Q000009:adverse effects; D018488:Bone Demineralization, Pathologic / Q000503:physiopathology; D015519:Bone Density / Q000502:physiology*; D005260:Female; D018475:Head-Down Tilt / Q000009:adverse effects / Q000502:physiology*; D006801:Humans; D008159:Lumbar Vertebrae / Q000293:injuries / Q000503:physiopathology*; D008297:Male; D009132:Muscles / Q000033:anatomy & histology; D010024:Osteoporosis / Q000503:physiopathology; D013026:Space Flight; D016103:Spinal Fractures / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D016474:Weight-Bearing; D014893:Weightlessness / Q000009:adverse effects*