title: Cellular and subcellular effect of heavy ions: a comparison of the induction of strand breaks and chromosomal aberration with the incidence of inactivation and mutation.
abstract: Radiobiological effects of heavy charged particles are compared for a large variety of ions from Helium to Uranium and energies between 1 and 1000 MeV/u which correspond to LET values between 10 and 16000 keV/micrometers. The different cross section for the induction of strand breaks and chromosomal aberrations as well as for inactivation and mutation induction exhibit striking similarities when compared as function of the linear energy transfer (LET). At LET values below 100 keV/micrometers all data points of one specific effect form one single curve as a function of LET, independent of the atomic number of the ion. In this LET range, the biological effects are independ from the particle energy or track structure and depend only on the energy transfer. Therefore, LET is a good parameter in this regime. For LET values greater than 100 keV/micrometers, the curves for the different ions separate from the common curve in order of increasing atomic numbers. In this regime LET is no longer a good parameter and the physical parameters of the formation of particle tracks are important. The similarity of the sigma-LET curves for different endpoints indicates that the 'hook-structure' is produced by physical and chemical effects which occur before the biologically relevant lesions are formed. However, from the existing data of biological effects, it can be concluded that the efficiencies for cell killing are always smaller than those extrapolated from X-ray data on the basis of the energy deposition only. Therefore, cells which are directly hit by an HZE particle are not killed and undergo a finite risk of mutation and transformation.
authors.affiliation: Gesellschaft fur Schwerionenforschung, Darmstadt, F.R.G.
authors.forename: G
authors.initials: G
authors.lastname: Kraft
authors.forename: W
authors.initials: W
authors.lastname: Kraft-Weyrather
authors.forename: S
authors.initials: S
authors.lastname: Ritter
authors.forename: M
authors.initials: M
authors.lastname: Scholz
authors.forename: J
authors.initials: J
authors.lastname: Stanton
mesh_terms: D000512:Alpha Particles; D000818:Animals; D001412:Bacillus subtilis; D010584:Bacteriophage phi X 174; D002461:Cell Line, Transformed; D002470:Cell Survival; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D020450:Heavy Ions; D018499:Linear Energy Transfer; D009154:Mutation; D012062:Relative Biological Effectiveness; D013539:Simian virus 40; D013171:Spores, Bacterial; D015003:Yeasts