Immunologic targets for currently available immunosuppressive agents: what is the optimal approach for children?
In this review, the authors discuss immunologic targets and events in T cells that are dysregulated by commonly used immunosuppressive agents. These include a description of glucocortcoid receptors as well as targets of glucocorticoids, targets of cyclosporine and FK506, and the mammalian target of rapamycin. In addition, novel antibody-based targets on T cells and antigen-presenting cells including the IL-2 receptor and costimulatory molecules are described. Finally, the authors provide a rationale for an optimal approach to immunosuppression in pediatrics. Because many of the newer immunosuppressive agents are currently in clinical trials, the "optimal" immunosuppressive strategy for the next decade is forthcoming.
Sho
M
M
Division of Nephrology, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Samsonov
D V
DV
Briscoe
D M
DM
D002648:Child; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D016030:Kidney Transplantation; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007166:Immunosuppressive Agents; D011965:Receptors, Glucocorticoid