title: Automated nasopharyngeal carcinoma detection with dynamic gadolinium-enhanced MR imaging.
abstract: OBJECTIVE
  The purpose of this research is to develop an automatic medical diagnosis for segmenting nasopharyngeal carcinoma (NPC) with dynamic gadolinium-enhanced MR imaging.
  
  
  METHODS
  This system is a multistage process, involving motion correction, head mask generation, dynamic MR data quantitative evaluation, rough segmentation, and rough segmentation refinement. Two approaches, a relative signal increase method and a slope method, are proposed for the quantitative evaluation of dynamic MR data.
  
  
  RESULTS
  The NPC detection results obtained using the proposed methods had a rating of 85% in match percent compared with these lesions identified by an experienced radiologist. The match percent for the two proposed methods did not have significant differences. However, the computation cost for the slope method was about twelve times faster than the relative signal increase method.
  
  
  CONCLUSIONS
  The proposed methods can identify the NPC regions quickly and effectively. This system can enhance the performance of clinical diagnosis.
authors.affiliation: Department of Computer Science and Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C.
authors.forename: C C
authors.initials: CC
authors.lastname: Hsu
authors.forename: P H
authors.initials: PH
authors.lastname: Lai
authors.forename: C
authors.initials: C
authors.lastname: Lee
authors.forename: W C
authors.initials: WC
authors.lastname: Huang
mesh_terms: D000704:Analysis of Variance; D002277:Carcinoma / Q000473:pathology*; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA