title: Synthesis and biological activities of (Z) and (E) alpha-ethenyl acyclonucleosides.
abstract: Synthesis of Z and E ethenyl acyclonucleosides (6a-e and 7a-e) via Michael addition of nucleobases with the diethyl acetylenedicarboxylate is described. The structures of compounds have been confirmed by spectral data. New compounds were found to be inactive against DNA and RNA viruses.
authors.affiliation: Laboratoire de Chimie Bio-Organique, Faculté des Sciences Semlalia, Marrakech, Morocco.
authors.forename: N
authors.initials: N
authors.lastname: Redwane
authors.forename: H B
authors.initials: HB
authors.lastname: Lazrek
authors.forename: J L
authors.initials: JL
authors.lastname: Barascut
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: M
authors.initials: M
authors.lastname: Witvrouw
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D048429:Cell Size / Q000187:drug effects; D004267:DNA Viruses / Q000187:drug effects*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006839:Hydrocarbons, Acyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012328:RNA Viruses / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D006839:Hydrocarbons, Acyclic; D009705:Nucleosides