title: Synthesis of N2-alkylguanosine using Mitsunobu reaction as a key step.
abstract: Peracetylated guanosine was reacted with POCl3 to give an 2-acetamido-6-chloro-9H-purine derivative, which was condensed with primary or secondary alcohols to give N2-alkylated analogues. The products were treated with mercaptoethanol in the presence of sodium methoxide to afford N2-alkylguanosines.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
authors.forename: A
authors.initials: A
authors.lastname: Yorikane
authors.forename: S
authors.initials: S
authors.lastname: Kozai
mesh_terms: D000107:Acetylation; D000478:Alkylation; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D006151:Guanosine