title: Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity.
abstract: Thieno analogues of the potent and selective furo-pyrimidine anti-VZV nucleoside family are herein reported. The compounds retain full antiviral potency in comparison to the furo parent.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, CF10 3XF, Cardiff, UK.
authors.forename: A
authors.initials: A
authors.lastname: Brancale
authors.forename: C
authors.initials: C
authors.lastname: McGuigan
authors.forename: B
authors.initials: B
authors.lastname: Algain
authors.forename: P
authors.initials: P
authors.lastname: Savy
authors.forename: R
authors.initials: R
authors.lastname: Benhida
authors.forename: J L
authors.initials: JL
authors.lastname: Fourrey
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006564:Herpesviridae / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D009705:Nucleosides / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D011743:Pyrimidines; D013876:Thiophenes