A novel arsenical in clam kidney identified by liquid chromatography/electrospray ionisation mass spectrometry.
Kidneys of clams of the genus Tridacna accumulate metabolic products from symbiotic unicellular algae that grow in the mantles of the clams. These metabolites include organoarsenic compounds that are biosynthesised by algae from arsenate in seawater. The arsenic compounds in aqueous extracts of the kidney of the giant clam T. derasa were investigated by liquid chromatography/electrospray ionisation mass spectrometry. About 50% of the water-soluble arsenic was present as dimethylarsinoylribosides and dimethylarsinate which are common algal metabolites. The major compound in the kidney (50% of water-soluble arsenic) was identified as a 5-dimethylarsinoyl-2,3,4-trihydroxycarboxylic acid, a new natural product.
Francesconi
K A
KA
Institute of Biology, University of Southern Denmark, DK-5230 Odense, Denmark. kevin.francesconi@kfunigraz.ac.at
Edmonds
J S
JS
D000818:Animals; D001152:Arsenicals / Q000032:analysis / Q000378:metabolism*; D049872:Bivalvia / Q000378:metabolism*; D002101:Cacodylic Acid / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*; D002853:Chromatography, Liquid / Q000379:methods*; D007668:Kidney / Q000378:metabolism*; D010421:Pentanoic Acids / Q000032:analysis / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
C437304:5-dimethylarsinoyl-2,3,4-trihydroxypentanoic acid; D001152:Arsenicals; D010421:Pentanoic Acids; D002101:Cacodylic Acid