title: Synthesis and in vitro cytotoxic evaluation of new derivatives of pyrido[1,2-a]benzimidazolic ring system: the pyrido[1',2':1,2]imidazo[4,5-h]quinazolines.
abstract: Access to the original series of pyrido[1',2':1,2]imidazo[4,5-h]quinazoline was developed from a 1,3-dicarbonyl unit with some "N-C-N" bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytotoxic activities against HL60 and A2780 cells. All compounds exhibited cytotoxic activities on resistant cell lines (MDR+; HL60R and A2780R) with no resistance phenomena.
authors.affiliation: Laboratoire de Chimie organique Pharmaceutique, E.A. 2414, Faculté de Pharmacie, Montpellier, France.
authors.forename: M
authors.initials: M
authors.lastname: Dupuy
authors.forename: F
authors.initials: F
authors.lastname: Pinguet
authors.forename: O
authors.initials: O
authors.lastname: Chavignon
authors.forename: J M
authors.initials: JM
authors.lastname: Chezal
authors.forename: J C
authors.initials: JC
authors.lastname: Teulade
authors.forename: J P
authors.initials: JP
authors.lastname: Chapat
authors.forename: Y
authors.initials: Y
authors.lastname: Blache
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D019450:Genes, MDR / Q000235:genetics; D018922:HL-60 Cells; D006801:Humans; D007150:Immunohistochemistry; D007202:Indicators and Reagents; D051379:Mice; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D007202:Indicators and Reagents; D011799:Quinazolines