[Effect of the novel III class anti-arrhythmia preparation (AL-275) in experimental myocardium and sympathetic stimulation].
AL-275, a new antiarrhythmic agent, exhibits the properties typical of the class III antiarrhythmogen: (i) prolongs the ventricular repolarization; (ii) inhibits the sinus node automatism; (iii) increases the effective refractory periods in atrium and ventricles; and (iv) does not modify AV and intraventricular conduction. AL-275 produces a pronounced antiarrhythmic and antifibrillatory action. The effect of AL-275 is independent of the heart rate, which is an advantage over the other class III agents. Both character and intensity of the electrophysiological and antiarrhythmic activity of AL-275 were fully retained upon the preliminary infusion of isoproterenol. Independence of the drug action of both the heart rate and the isoproterenol-induced changes in refractoriness are related to the ability of AL-275 to block a slow component (IKs) of the potassium current.
Kaverina
N V
NV
Laboratory of Circulation System Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Lyskovtsev
V V
VV
Kishchuk
E P
EP
D000322:Adrenergic Agonists / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000517:prevention & control*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003514:Cyclohexylamines / Q000494:pharmacology*; D004285:Dogs; D004558:Electric Stimulation; D004562:Electrocardiography; D007545:Isoproterenol / Q000494:pharmacology; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*
C117100:AWD 160-275; D000322:Adrenergic Agonists; D000596:Amino Acids; D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D003514:Cyclohexylamines; D007545:Isoproterenol