Modification of host cell apoptosis by viral and bacterial pathogens.
Bacterial and viral pathogens have evolved sophisticated strategies to manipulate the host cell's life span to their own advantage. This is achieved by modifications of the intrinsic apoptosis program at several checkpoints: kinases, caspases and mitochondria. The goal of this review is to give an overview over the molecular mechanisms involved.
Müller
A
A
MPI für Infektionsbiologie, Abt. Molekulare Biologie, Berlin, Germany. mueller@mpiib-erlin.mpg.de
Rudel
T
T
D017209:Apoptosis; D001419:Bacteria / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D020169:Caspases / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D015398:Signal Transduction; D014777:Virus Diseases / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D014780:Viruses / Q000472:pathogenicity*
D020169:Caspases