Integrating stress-response and cell-cycle checkpoint pathways.
The DNA integrity checkpoint and stress kinase (SAPK/JNK and p38) pathways function to modulate cell-cycle, apoptotic and transcriptional responses to stress. Although initially considered to function independently, recent advances indicate a number of links between the stress-response and checkpoint pathways. Here, we consider the relationship between the stress-response and checkpoint pathways and how they interact to modulate cell-cycle control.
Pearce
A K
AK
Cell Cycle Laboratory, MRC Radiation and Genome Stability Unit, Harwell, OX11 0RD, Didcot, UK.
Humphrey
T C
TC
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D000071877:Checkpoint Kinase 1; D064447:Checkpoint Kinase 2; D004249:DNA Damage; D004261:DNA Replication / Q000502:physiology; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D018384:Oxidative Stress / Q000502:physiology*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic; D015003:Yeasts
D011494:Protein Kinases; D064447:Checkpoint Kinase 2; D000071877:Checkpoint Kinase 1; D017346:Protein Serine-Threonine Kinases