Intramuscular calcium movements: experiments from the Soviet biosatellite Biocosmos.
Experiments have been performed in skeletal muscle fibres from the lateral head of gastrocnemius muscle of female rats. Changes in intramuscular calcium movements due to microgravity conditions have been tested by tension measurements in chemically skinned muscle fibres. Our results show that microgravity induces i) a decrease in maximal muscle strength developed by contractile proteins ii) a decrease of intensity and rate of both Ca release and Ca uptake by the sarcoplasmic reticulum.
Goblet
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C
Laboratoire de Physiologie des Structures Contractiles, Universite des Sciences et Techniques de Lille I, France.
Holy
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Mounier
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Y
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D005260:Female; D018656:Muscle Fibers, Fast-Twitch / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D009124:Muscle Proteins / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D013026:Space Flight; D013718:Tensile Strength; D014893:Weightlessness
D000697:Central Nervous System Stimulants; D009124:Muscle Proteins; D002110:Caffeine; D000252:Calcium-Transporting ATPases; D002118:Calcium