A cyclobutane carbonucleoside with marked selectivity against TK+ and TK- varicella zoster virus.
Several cyclobutyladenine and analogous carbonucleosides were synthesized from 1R-alpha-pinene and their anti-viral activity was tested. One of them (3e) showed interesting selectivity against both TK+ and TK- VZV.
López
C
C
Dpto. Química Orgánica, Universidade de Santiago, E-15706, Santiago de Compostela, Spain.
Balo
C
C
Blanco
J M
JM
Fernández
F
F
De Clercq
E
E
Balzarini
J
J
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000494:pharmacology*; D014645:Herpesvirus 3, Human / Q000187:drug effects* / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology*
D000998:Antiviral Agents; D003503:Cyclobutanes; D009705:Nucleosides