[Current advance in insulin signal transduction].
Evidence has suggested that the insulin receptor substarate(IRS)-phosphoinositide 3-kinase(PI3K) pathway plays a central role in metabolic actions of insulin. The downstream effectors that mediate PI 3-kinase-dependent actions, such as Akt or atypical PKC, have been identified. Lipid and protein phosphatases that modulate the IRS-PI3 K pathway are implicated in the development of insulin resistance. The abundance of IRS, regulated at the level of both mRNA and protein, may also contribute to the sensitivity of cells to insulin. Tissue-specific insulin receptor knockout mice involved in insulin signaling are disrupted have reveled the impact of the defects of insulin signaling in a specific tissue.
Ogawa
W
W
Second Department of Internal Medicine, Kobe University School of Medicine.
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D004734:Energy Metabolism; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D019204:GTP-Binding Proteins / Q000502:physiology; D051275:Glucose Transporter Type 4; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance; D051379:Mice; D009004:Monosaccharide Transport Proteins / Q000378:metabolism; D009124:Muscle Proteins; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D011972:Receptor, Insulin / Q000502:physiology; D015398:Signal Transduction; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D051275:Glucose Transporter Type 4; D007328:Insulin; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495692:SLC2A4 protein, human; C497387:SREBF1 protein, human; C495693:Slc2a4 protein, mouse; C497388:Srebf1 protein, mouse; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin; D019204:GTP-Binding Proteins