[Effect of novel derivatives of 1,2,4-triazolyl-5-mercaptoacetic acid on the reductase activity in the liver microsomes in adult and old rats with immobilization-induced stress].
The effect of 3-(4-pyridyl)-1,2,4-triazolyl-5-mercaptoacetic acid morpholinium salt (rumosol) and potassium salt (drug 2) on the liver microsomal reductase activity was studied in adult (aged 10-12 months) and old (22-25 months) Wistar rats under immobilization stress conditions. In the group of adult rats, both drugs showed comparable moderate inhibiting effect. In the group of old rats, rumosol injections produced the reductase activation up to a level characteristic of the intact old animals.
Rud'ko
N P
NP
Biological Chemistry Department, Zaporozhye State Medical University, Mayakovskogo ul 26, Zaporozhye, 690035 Ukraine.
Davydov
V V
VV
D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D007103:Immobilization; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000201:enzymology*; D013864:Thioglycolates / Q000138:chemical synthesis / Q000494:pharmacology*
C437303:1,2,4-triazolyl-5-mercaptoacetic acid; D000085:Acetates; D013864:Thioglycolates; D010088:Oxidoreductases