title: Oligomerization of deoxynucleoside-bisphosphate dimers:  template and linkage specificity.
abstract: Evidence is presented that a poly(U) template selectively favors the oligomerization of the activated, 3'-5' pyrophosphate-linked dimer pdAppdAp, in comparison with the 3'-3' and 5'-5' linked dimers.  In the absence of poly(U), the 5'-5' linked dimer is the most reactive, and chains are formed which are more than 60 monomer units in length.
authors.affiliation: Laboratory for Exobiology, University of Nijmegen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Visscher
authors.forename: R
authors.initials: R
authors.lastname: van der Woerd
authors.forename: C G
authors.initials: CG
authors.lastname: Bakker
authors.forename: A W
authors.initials: AW
authors.lastname: Schwartz
mesh_terms: D003853:Deoxyribonucleosides / Q000032:analysis / Q000138:chemical synthesis*; D019281:Dimerization; D011756:Diphosphates / Q000032:analysis / Q000737:chemistry; D019143:Evolution, Molecular; D009841:Oligonucleotides / Q000032:analysis / Q000138:chemical synthesis*; D010710:Phosphates / Q000032:analysis / Q000378:metabolism*; D011119:Polynucleotides / Q000032:analysis / Q000138:chemical synthesis; D013698:Templates, Genetic
chemical_list: D003853:Deoxyribonucleosides; D011756:Diphosphates; D009841:Oligonucleotides; D010710:Phosphates; D011119:Polynucleotides