title: Endovascular radiotherapy for stenosis after percutaneous transluminal coronary angioplasty.
abstract: The rate of restenosis after percutaneous transluminal coronary angioplasty ranges from 30% to 60%. Despite numerous trials, no effective pharmacological therapy has been found. This late effect can be reduced by endovascular radiotherapy. In animal models of restenosis after balloon injury, there is marked reduction of neointimal proliferation when the injured vessel is irradiated, using a variety of radiation sources and delivery systems. Early human trials did not focus on the importance of source selection and calibration. Other aspects which should be carefully determined are source selection and responsibilities of the treatment team. These matters are reviewed and discussed.
authors.affiliation: GATA Radiation Oncology Department, Ankara, Turkey.
authors.forename: H C
authors.initials: HC
authors.lastname: Ulutin
authors.forename: Y
authors.initials: Y
authors.lastname: Pak
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D001918:Brachytherapy; D023903:Coronary Restenosis / Q000532:radiotherapy*; D003331:Coronary Vessels / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D011868:Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use; D011879:Radiotherapy Dosage
chemical_list: D011868:Radioisotopes