title: Octreotide for severe acute bleeding from portal hypertensive colopathy: a case report.
abstract: A 56-year-old man developed severe lower gastrointestinal bleeding. He was classified as Child-Pugh grade C. Colonoscopy revealed multiple angiodysplasia-like lesions and mucosal friability throughout the entire colon (portal hypertensive colopathy, PHC). Haemostasis was immediately achieved with octreotide treatment, although melaena recurred after discontinuation of the infusion. Propranolol treatment before discontinuation of octreotide infusin prevented the recurrence of bleeding from PHC. Octreotide is a safe and effective treatment for severe acute bleeding from PHC, especially if the patient is not a candidate for transjugular intrahepatic portosystemic shunt (TIPS) or treatment with a beta-blocker due to the severity of liver disease or haemodynamic instability. However, a sufficient reduction of portal pressure by propranolol or other medical treatment may be needed in order to discontinue octreotide infusion without the recurrence of bleeding.
authors.affiliation: Second Department of Internal Medicine, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama City 236-004, Japan. kyoshie@med.yokohama-cu.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Yoshie
authors.forename: Y
authors.initials: Y
authors.lastname: Fujita
authors.forename: A
authors.initials: A
authors.lastname: Moriya
authors.forename: I
authors.initials: I
authors.lastname: Kawana
authors.forename: K
authors.initials: K
authors.lastname: Miyamoto
authors.forename: S
authors.initials: S
authors.lastname: Umemura
mesh_terms: D000208:Acute Disease; D003108:Colonic Diseases / Q000188:drug therapy* / Q000209:etiology; D003113:Colonoscopy; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications* / Q000175:diagnosis; D007262:Infusions, Intravenous; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000008:administration & dosage*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D006490:Hemostatics; D015282:Octreotide