title: HLA-DQ alleles in patients with celiac disease in Turkey.
abstract: The prevalence of the HLA-DQA1 and DQB1 alleles in 55 Turkish children with celiac disease and 50 control subjects was investigated by using an allele-specific DNA-based polymerase chain reaction-sequence-specific primer (PCR-SSP) method. The frequency of the DQA1*0501 and DQB1*02 alleles was higher in celiac patients than in controls. The DQA1B1 (*0501; *02) haplotype was present in 46 (83.6%) patients and only in 12 (24%) controls. The remaining 9 celiac patients which were negative for DQA1B1 (*0501;*02) carried the DQA1B1 (*03;*0302) haplotype. We found an excess homozygosity of the DQB1*02 allele and the DQA1B1 (*0501;*02) haplotype in the patients. No statistically significant correlation was found between the homozygosity of this haplotype or the DQB1*02 allele and an earlier onset of the disease.
authors.affiliation: Division of Genetics, Department of Pediatrics, Cerrahpaşa Faculty of Medicine, University of Istanbul, Istanbul, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Tüysüz
authors.forename: A
authors.initials: A
authors.lastname: Dursun
authors.forename: T
authors.initials: T
authors.lastname: Kutlu
authors.forename: S
authors.initials: S
authors.lastname: Sökücü
authors.forename: N
authors.initials: N
authors.lastname: Cine
authors.lastname: Süoğlu O
authors.forename: T
authors.initials: T
authors.lastname: Erkan
authors.forename: N
authors.initials: N
authors.lastname: Erginel-Unaltuna
authors.forename: G
authors.initials: G
authors.lastname: Tümay
mesh_terms: D000293:Adolescent; D000483:Alleles; D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology; D002648:Child; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D008297:Male; D018807:Polymorphism, Single-Stranded Conformational; D014421:Turkey
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen