title: A cyclobutane carbonucleoside with marked selectivity against TK+ and TK- varicella zoster virus.
abstract: Several cyclobutyladenine and analogous carbonucleosides were synthesized from 1R-alpha-pinene and their anti-viral activity was tested. One of them (3e) showed interesting selectivity against both TK+ and TK- VZV.
authors.affiliation: Dpto. Química Orgánica, Universidade de Santiago, E-15706, Santiago de Compostela, Spain.
authors.forename: C
authors.initials: C
authors.lastname: López
authors.forename: C
authors.initials: C
authors.lastname: Balo
authors.forename: J M
authors.initials: JM
authors.lastname: Blanco
authors.forename: F
authors.initials: F
authors.lastname: Fernández
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000494:pharmacology*; D014645:Herpesvirus 3, Human / Q000187:drug effects* / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D003503:Cyclobutanes; D009705:Nucleosides