title: Helium-ion-induced human cataractogenesis.
abstract: Retrospective and ongoing analyses of clinical records from 347 primary intraocular melanoma patients treated with helium ions at LBL will allow examination of the exposure-response data for human cataract; which is a complication of the therapy from incidental exposure of the lens.  Direct particle beam traversal of at least a portion of the lens usually is unavoidable in treatment of posterior intraocular tumors.  The precise treatment planned for each patient permits quantitative assessment of the lenticular dose and its radiation quality.  We are reporting our preliminary results on the development of helium-ion-induced lens opacifications and cataracts in 54 of these patients who had 10% or less of their lens in the treatment field.  We believe these studies will be relevant to estimating the human risk for cataract in space flight.
authors.affiliation: Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Blakely
authors.forename: I K
authors.initials: IK
authors.lastname: Daftari
authors.forename: W J
authors.initials: WJ
authors.lastname: Meecham
authors.forename: L C
authors.initials: LC
authors.lastname: Alonso
authors.forename: J M
authors.initials: JM
authors.lastname: Collier
authors.forename: S M
authors.initials: SM
authors.lastname: Kroll
authors.forename: E L
authors.initials: EL
authors.lastname: Gillette
authors.forename: A C
authors.initials: AC
authors.lastname: Lee
authors.forename: J T
authors.initials: JT
authors.lastname: Lett
authors.forename: A B
authors.initials: AB
authors.lastname: Cox
authors.forename: J R
authors.initials: JR
authors.lastname: Castro
authors.forename: D H
authors.initials: DH
authors.lastname: Char
mesh_terms: D000328:Adult; D000337:Aerospace Medicine; D000368:Aged; D002386:Cataract / Q000209:etiology*; D005500:Follow-Up Studies; D006371:Helium / Q000009:adverse effects*; D006801:Humans; D007477:Ions; D007908:Lens, Crystalline / Q000528:radiation effects*; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D010315:Particle Accelerators; D011832:Radiation Injuries / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D018570:Risk Assessment; D014604:Uveal Neoplasms / Q000532:radiotherapy*
chemical_list: D007477:Ions; D006371:Helium