[Protective effects of gangliosides on cerebral neuronal damage of rat during acute hypoxia].
OBJECTIVE
To observe the preventive and therapeutic effects of gangliosides on acute altitude hypoxic brain damage.


METHODS
Fifteen Wistar rats, weighed 180-220 g, were randomly divided into 3 groups, hypoxia group A, hypoxia group B and normoxia group. The rats in hypoxia group A were exposed to a simulated altitude of 7000 m for 5 hours and the rats in hypoxia group B were exposed to hypoxia after intraperitoneal administration of mixed gangliosides (100 mg/kg/d) for 3 days.


RESULTS
Gangliosides could ameliorate the severity of damage in neuronal bodies, cellular skeletons and synapses, especially in synapses.


CONCLUSIONS
It is suggested that gangliosides are effective in preventing and treating hypoxic brain damages by decreasing the accumulation of intracellular Ca2+, and stabilizing CaM and CaM PKII activity during acute hypoxia.
Xie
Y Z
YZ
Institute of Hygiene and Environmental Medicine Academy of Military Medical Sciences, Tianjin, China.
Zhang
B
B
Yang
X M
XM
Yin
Z Y
ZY
Bai
J W
JW
Yang
H X
HX
D000532:Altitude Sickness / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D001274:Atmospheric Pressure; D002540:Cerebral Cortex / Q000503:physiopathology / Q000648:ultrastructure; D005732:Gangliosides / Q000627:therapeutic use*; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000517:prevention & control; D008928:Mitochondria; D009474:Neurons / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000648:ultrastructure
D005732:Gangliosides