The synthesis of, and studies on, 2'-C-modified nucleotides.
The synthesis of uridine monomers containing either a 2'-deoxy-2'-C-methylcyano or ethylcyano group is described. These monomers are intended for incorporation into oligonucleotides to investigate a proposed duplex-stabilising effect exerted by 2'-tethered amide groups.
Brennan
L
L
Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom.
Fettes
K J
KJ
O'Neil
I A
IA
Cosstick
R
R
D011742:Pyrimidine Nucleotides / Q000138:chemical synthesis*; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D011742:Pyrimidine Nucleotides; D014529:Uridine