Chemical synovectomy in haemophilia: status and challenges.
Chemical synovectomy has been used for the last three decades as an alternative for surgical synovectomy in the treatment of chronic haemophilic synovitis. Comparable results have been obtained with the many different radionuclides used: decreased bleeding, decreased pain and stable range of motion, in more than 50% of treated patients. Yttrium 90Y and Phosphorus 32P seem to be the isotopes of choice. Osmic acid and rifampicine have been used in a relatively small number of subjects. Global result of treatment with these two pro-ducts seems to be less favourable than with radionuclides. Late effects of chemical synovectomy are not known.
Rivard
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Hôpital Sainte-Justine, 3175 Côte-Sainte-Catherine, Montreal, Canada, H3T 1C5. rivardge@medclin.umontreal.ca
D006395:Hemarthrosis / Q000150:complications / Q000188:drug therapy / Q000209:etiology; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D009993:Osmium Tetroxide / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D011868:Radioisotopes / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D013583:Synovial Membrane / Q000187:drug effects / Q000528:radiation effects; D013585:Synovitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D009993:Osmium Tetroxide; D012293:Rifampin