[Acute peripheral demyelinating polyneuropathy and acute renal failure after administration of FK506].
FK 506 is a potent immunosuppressive agent in clinical use in solid organ transplantation since 1989. Approximately 5% of patients receiving FK 506 develop major central nervous system toxicity but peripheral nervous system involvement is very uncommon, and there are only 4 reported cases of demyelinating polyneuropathy in patients who received a liver transplant. We report a case of demyelinating polyneuropathy associated with the use of FK 506 in a renal transplant recipient.
Laham
G
G
Servicio de Nefrología del Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina. glaham@intramed.net.ar
Vilches
A
A
Jost
L
L
Jost
L
L
Nogués
M
M
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D003711:Demyelinating Diseases / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D009431:Neural Conduction; D011115:Polyneuropathies / Q000139:chemically induced*; D016559:Tacrolimus / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D016559:Tacrolimus