Free radicals induced in solid DNA by heavy ion bombardment.
Free radical formation after heavy-ion bombardment was studied in solid, polycristalline pellets of DNA-constituents by analysing the dose-yield curves and the spectra obtained by ESR-spectroscopy at low (< 100 K) and ambient temperatures. The dose-yield curves were found to correlate with those found after X-irradiation but shifted to higher doses and lower saturation concentrations. The corresponding radical yields (per 100 eV) exhibit values which are one to two orders of magnitudes lower. The structural aspects as revealed from powder ESR-spectra gave a complex inter-relation between substance, LET, dose and irradiation temperature, which is discussed in terms of mechanistic models.
Huttermann
J
J
Fachrichtung Biophysik und Phys. Grundlagen der Medizin, Universitat des Saarlandes, Homburg/Saar, F.R.G.
Schaefer
A
A
Kraft
G
G
D000241:Adenosine / Q000528:radiation effects; D003596:Cytosine / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects*; D003841:Deoxycytidine / Q000528:radiation effects; D003857:Deoxyuridine / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D020450:Heavy Ions; D018499:Linear Energy Transfer; D009705:Nucleosides / Q000528:radiation effects*; D011854:Radiochemistry; D013941:Thymine / Q000528:radiation effects; D014965:X-Rays
D005609:Free Radicals; D009705:Nucleosides; D003841:Deoxycytidine; D003596:Cytosine; D004247:DNA; D000241:Adenosine; D013941:Thymine; D003857:Deoxyuridine