A single dose of nebulized budesonide decreases exhaled nitric oxide in children with acute asthma.
This study was conducted to investigate whether a single dose of nebulized budesonide effectively decreased airway inflammation as demonstrated by exhaled nitric oxide (eNO) levels. A single dose of nebulized budesonide, but not nebulized terbutaline, rapidly decreased eNO levels in 6 hours. The decrease in eNO levels induced by nebulized budesonide was correlated to an increase in peak expiratory flow rate.
Tsai
Y G
YG
Department of Pediatrics, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Lee
M Y
MY
Yang
K D
KD
Chu
D M
DM
Yuh
Y S
YS
Hung
C H
CH
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019819:Budesonide / Q000008:administration & dosage / Q000627:therapeutic use*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009330:Nebulizers and Vaporizers; D009569:Nitric Oxide / Q000378:metabolism*; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D013726:Terbutaline / Q000008:administration & dosage / Q000494:pharmacology*
D001993:Bronchodilator Agents; D009569:Nitric Oxide; D019819:Budesonide; D013726:Terbutaline