title: Terrestrial applications of bone and muscle research in microgravity.
abstract: Major applications to people on Earth are possible from NASA-sponsored research on bone and muscle which is conducted either in microgravity or on Earth using models mimicking microgravity.  In microgravity bone and muscle mass are lost.  Humans experience a similar loss under certain conditions on Earth.  Bone and muscle loss exist on Earth as humans age from adulthood to senescence, during limb immobilization for healing of orthopedic injuries, during wheelchair confinement because of certain diseases, and during chronic bed rest prescribed for curing of diseases.  NASA-sponsored research is dedicated to learning both what cause bone and muscle loss as well as finding out how to prevent this loss.  The health ramifications of these discoveries will have major impact.  Objective 1.6 of Healthy People 2000, a report from the U.S. Department of Health and Human Services, states that the performance of physical activities that improve muscular strength, muscular endurance, and flexibility is particularly important to maintaining functional independence and social integration in older adults.  This objective further states that these types of physical activities are important because they may protect against disability, an event which costs the U.S. economy huge sums of money.  Thus NASA research related to bone and muscle loss has potential major impact on the quality of life in the U.S.  Relative to its potential health benefits, NASA and Congressional support of bone and muscle research is funded at a very low level.
authors.affiliation: Department of Physiology and Cell Biology, University of Texas Medical School at Houston 77225.
authors.forename: F W
authors.initials: FW
authors.lastname: Booth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D018488:Bone Demineralization, Pathologic / Q000503:physiopathology / Q000517:prevention & control; D001842:Bone and Bones / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology* / Q000503:physiopathology; D009133:Muscular Atrophy / Q000503:physiopathology / Q000517:prevention & control; D012106:Research; D013026:Space Flight; D018581:Technology Transfer; D014481:United States; D018557:United States National Aeronautics and Space Administration; D014893:Weightlessness / Q000009:adverse effects*; D018474:Weightlessness Simulation