[Pharmacokinetics of lipophen--a novel combined phospholipid liver protective agent of natural origin].
Study of the labeled lipophen distribution in organs and tissues of experimental animals showed evidence of a nonlinear drug pharmacokinetics. The maximum amount of labeled lipophen accumulated in liver, spleen, and kidneys, while the drug content in heart, muscles, and brain was very small. The products of lipophen metabolism are excreted with both urine and feces.
Gordienko
A D
AD
Central Research Institute, National Pharmaceutical Academy of Ukraine, ul. Pushkinskaya 53, Kharkov, 310002 Ukraine.
Bozhkov
A I
AI
D000284:Administration, Oral; D000818:Animals; D004338:Drug Combinations; D005419:Flavonoids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism*; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution; D014815:Vitamins / Q000008:administration & dosage / Q000493:pharmacokinetics*
D004338:Drug Combinations; D005419:Flavonoids; D010713:Phosphatidylcholines; D014815:Vitamins; C435543:lipophen