Insights into the Role of Infection in the Spondyloarthropathies.
Certain infections play an important role in the pathogenesis of the human leukocyte antigen (HLA)-B27-associated reactive arthritis. Whether infections play a role in other forms of spondyloarthropathies is not as clear. The role of HLA-B27 as an antigen-presenting molecule is important in the pathogenesis of these diseases. Recent evidence has been obtained indicating that this molecule may have other functions unrelated to antigen-presentation in the interaction of reactive arthritis-triggering microbes and host. This paper reviews the recent studies on the role of infection in the spondyloarthropathies.
Liu
Y
Y
National Public Health Institute, Department in Turku, Kiinamyllynkatu 13, FIN-20520 Turku, Finland. yiliu@utu.fi
Penttinen
M A
MA
Granfors
K
K
D000818:Animals; D016918:Arthritis, Reactive / Q000276:immunology / Q000503:physiopathology; D001424:Bacterial Infections / Q000276:immunology* / Q000503:physiopathology*; D015415:Biomarkers / Q000032:analysis; D005260:Female; D015796:HLA-B27 Antigen / Q000276:immunology*; D006801:Humans; D008297:Male; D051379:Mice; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D025242:Spondylarthropathies / Q000276:immunology* / Q000503:physiopathology*; D013167:Spondylitis, Ankylosing / Q000276:immunology / Q000503:physiopathology
D015415:Biomarkers; D015796:HLA-B27 Antigen