title: Prognostic value of cytokines in SIRS general medical patients.
abstract: We studied 174 patients with SIRS criteria, 45 with sepsis, eight with severe sepsis and 13 with septic shock. Serum TNF-alpha, IL-6, IL-8 and IL-10 levels were raised in SIRS patients, even in those cases in which an infection could not be documented, and more intensely in severe sepsis and in patients who died (11%). The slope of the regression line between IL-10 and TNF-alpha was sharper in patients with severe sepsis and in those who died; an imbalance between pro- and anti-inflammatory cytokines may be related to poor prognosis. Increased IL-6 and IL-10, decreased muscle mass, raised BUN and low body temperature were all independently related to prognosis.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez-Gaspar
authors.forename: F
authors.initials: F
authors.lastname: Santolaria
authors.forename: A
authors.initials: A
authors.lastname: Jarque-López
authors.forename: E
authors.initials: E
authors.lastname: González-Reimers
authors.forename: A
authors.initials: A
authors.lastname: Milena
authors.forename: M J
authors.initials: MJ
authors.lastname: de la Vega
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez-Rodríguez
authors.forename: J L
authors.initials: JL
authors.lastname: Gómez-Sirvent
mesh_terms: D000367:Age Factors; D000368:Aged; D001831:Body Temperature; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D016753:Interleukin-10 / Q000096:biosynthesis / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D011379:Prognosis; D018805:Sepsis / Q000175:diagnosis* / Q000276:immunology* / Q000401:mortality; D012772:Shock, Septic / Q000175:diagnosis* / Q000276:immunology* / Q000401:mortality; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10