Synthesis and biological evaluation of pyridin-2-one nucleosides.
The synthesis of 1-(beta-D-ribofuranosyl)pyridin-2-one-3-carboxylic acid and the 3-carboxamide as well as a short series of 3N-carboxamides, prepared by TPTU/HOBt coupling of primary amines with 1-(beta-D-ribofuranosyl)pyridin-2-one-3-carboxylic acid, and their evaluation as anti-infective agents is described.
Huntley
C M
CM
Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, United Kingdom.
Cotterill
A S
AS
Maillard
J Y
JY
Balzarini
J
J
Simons
C
C
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000577:Amides; D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D011725:Pyridines; D012263:Ribonucleosides