Effects of cold stress and epinephrine on degranulation of peritoneal mast cells in rats.
We studied the effects of histamine liberators calcium ionophore A23187 and substance 48/80 on mast cells during cold stress and epinephrine load. Under the effect of both stress factors, ionophore A23187-induced histamine release from mast cells underwent more pronounced changes than that stimulated by substance 48/80. Cold stress and epinephrine load produce different changes in functional activity of Ca2+ channels in mast cell membranes.
Graevskaya
E E
EE
Department of Biophysics, Laboratory of Radiational Biophysics, Biological Faculty, M. V. Lomonosov Moscow State University. graevsk@biophys.msu.ru
Akhalaya
M Y
MY
Goncharenko
E N
EN
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D015550:Cell Degranulation / Q000187:drug effects*; D003080:Cold Temperature; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006636:Histamine Release; D007476:Ionophores / Q000494:pharmacology; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D010537:Peritoneum / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000473:pathology*
D007476:Ionophores; D000001:Calcimycin; D002118:Calcium; D004837:Epinephrine