[Computer searching of new targets for antimicrobial drugs based on comparative analysis of genomes].
The progress in genome research allows to use genomic databases for drug discovery. The major interest consists in their usage for searching of new molecular targets for new drugs. It is especially important in the area of new antimicrobial drugs creation. In recent years, the applicability of genome analysis for solution of this problem was shown by different authors. We propose an approach for searching new targets for antimicrobial drugs based upon comparative analysis of genomes and samples from molecular databases. For each protein encoded by the target microorganism genome the conformance to a number of medico-biological and technological requirements was tested. The obtained evaluations were used for selection of potential targets. The approach was implemented in the original software GenMesh. It was successfully tested with known targets of drugs against tuberculosis when correct valuations were obtained. The attempt of new targets selection for design of new drugs against tuberculosis was done with reliable results.
Dubanov
A V
AV
Orekhovich Institute of Biomedical Chemistry, RAMS Pogodinskaya str. 10, Moscow, 119992, Russia. dubanov@ibmh.msk.su
Ivanov
A S
AS
Archakov
A I
AI
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000187:drug effects / Q000235:genetics; D015195:Drug Design; D016680:Genome, Bacterial; D012984:Software
D000890:Anti-Infective Agents; D001426:Bacterial Proteins