title: Model based characterization of microgravity induced alterations of CVS-regulation.
abstract: A concept called model individualization is presented. It is used to modify computer based models to reproduce observed individual behavior. During D2-, MIR97- and Neurolab-missions tilt-table and LBNP-experiments were carried out. Physiological data describing the cardiovascular reactions of the astronauts were recorded. The appropriateness of the rheoretical principles is demonstrated with MIR97 tilt-table experiments. Finally the resulting individualized model is investigated to propose hypotheses on probable alterations in the cardiovascular system induced by microgravity.
authors.affiliation: Bonn University, Department of Computer Science I, Germany. aster@cs.uni-bonn.de
authors.forename: A
authors.initials: A
authors.lastname: Asteroth
authors.forename: J
authors.initials: J
authors.lastname: Frings
authors.forename: K
authors.initials: K
authors.lastname: Moller
authors.forename: L
authors.initials: L
authors.lastname: Beck
authors.forename: J
authors.initials: J
authors.lastname: Drescher
mesh_terms: D000337:Aerospace Medicine / Q000379:methods; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D005069:Evaluation Studies as Topic; D006339:Heart Rate; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology*; D008150:Lower Body Negative Pressure; D008955:Models, Cardiovascular; D011237:Predictive Value of Tests; D013026:Space Flight; D018667:Tilt-Table Test; D014893:Weightlessness