title: Increased RNA affinity of HNA analogues by introducing alkoxy substituents at the C-1 or C-3 position.
abstract: 1,5-Anhydrohexitol nucleoside congeners with alkoxy substituents, were prepared, resulting in a further improvement of their RNA affinity and antisense potential.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: M
authors.initials: M
authors.lastname: Meldgaard
authors.forename: F
authors.initials: F
authors.lastname: Volders
authors.forename: G
authors.initials: G
authors.lastname: Schepers
authors.forename: J
authors.initials: J
authors.lastname: Rozenski
authors.forename: P
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D007700:Kinetics; D009705:Nucleosides / Q000138:chemical synthesis* / Q000378:metabolism; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000378:metabolism; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013402:Sugar Alcohols / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D009705:Nucleosides; D016376:Oligonucleotides, Antisense; D013402:Sugar Alcohols; D012313:RNA