Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.
Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.
Marwah
S S
SS
Department of Haematology, City Hospital Trust, Dudley Road, Birmingham B18 7QH, UK. Sukhjinder.Marwah@cityhospbham.wmids.nhs.uk
Wheelwright
D
D
Blann
A D
AD
Rea
C
C
Beresford
R
R
Phillips
J D
JD
Wright
J
J
Bareford
D
D
D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000628:therapy; D000975:Antioxidants / Q000032:analysis*; D001803:Blood Transfusion; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D018709:Statistics, Nonparametric; D014168:Transferrin / Q000032:analysis; D014810:Vitamin E / Q000097:blood*
D000975:Antioxidants; D014168:Transferrin; D014810:Vitamin E; D007501:Iron