title: Analysis of mutant quantity and quality in human-hamster hybrid AL and AL-179 cells exposed to 137Cs-gamma or HZE-Fe ions.
abstract: We measured the number of mutants and the kinds of mutations induced by 137Cs-gamma and by HZE-Fe (56Fe [600 MeV/amu, LET = 190 KeV/micrometer) in standard AL human hamster hybrid cells and in a new variant hybrid, AL-179.  We found that HZE-Fe was more mutagenic than 137Cs-gamma per unit dose (about 1.6 fold), but was slightly less mutagenic per mean lethal dose, DO, at both the S1 and hprt- loci of AL cells. On the other hand, HZE-Fe induced about nine fold more complex S1- mutants than 137Cs-gamma rays, 28% vs 3%. 137Cs-gamma rays induced about twice as many S1- mutants and hprt-mutants in AL-179 as in AL cells, and about nine times more of the former were complex, and potentially unstable kinds of mutations.
authors.affiliation: Department of Radiological Health Sciences (MRB), Colorado State University, Fort Collins 80523, USA.
authors.forename: C
authors.initials: C
authors.lastname: Waldren
authors.forename: D
authors.initials: D
authors.lastname: Vannais
authors.forename: R
authors.initials: R
authors.lastname: Drabek
authors.forename: D
authors.initials: D
authors.lastname: Gustafson
authors.forename: S
authors.initials: S
authors.lastname: Kraemer
authors.forename: M
authors.initials: M
authors.lastname: Lenarczyk
authors.forename: A
authors.initials: A
authors.lastname: Kronenberg
authors.forename: T
authors.initials: T
authors.lastname: Hei
authors.forename: A
authors.initials: A
authors.lastname: Ueno
mesh_terms: D000818:Animals; D016466:CHO Cells; D002588:Cesium Radioisotopes; D002880:Chromosomes, Human, Pair 11 / Q000528:radiation effects; D006224:Cricetinae; D004247:DNA / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D020450:Heavy Ions; D006801:Humans; D006822:Hybrid Cells / Q000528:radiation effects*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D007501:Iron; D016296:Mutagenesis; D009154:Mutation
chemical_list: D002588:Cesium Radioisotopes; D004247:DNA; D007501:Iron; D007041:Hypoxanthine Phosphoribosyltransferase