Extended-spectrum beta-lactamases.
Extended-spectrum beta lactamase (ESBL) producing gram-negative bacilli are a growing concern, especially because the species of organisms producing these enzymes are increasing. Bacteria possessing these enzymes are resistant to third-generation cephalosporins--antimicrobial agents important for inpatient therapy. These resistant organisms are clinically important because they result in increased morbidity and mortality. Additionally, some laboratories may have difficulty detecting ESBL-producing organisms. These and other issues are discussed in this article.
Blondeau
J M
JM
Department of Clinical Microbiology, Royal University and Saskatoon City Hospitals, Saskatchewan, Canada. blondeauj@sdh.sk.ca
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000201:enzymology*; D001431:Bacteriological Techniques; D006801:Humans; D001618:beta-Lactamases / Q000502:physiology*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases