The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein.
The mouse Fgfrl1 gene codes for a novel cell surface protein that is closely related to the family of the FGF receptors. It contains three extracellular Ig C2 loops and an acidic box, which share 29-33% sequence identity (48-50% similarity) with FGF receptors 1-4. The intracellular portion of the novel protein, however, lacks a tyrosine kinase domain required for signal transduction by transphosphorylation. The gene for Fgfrl1 comprises six exons and is located on mouse chromosome 5 in close proximity to the Idua gene for L-iduronidase.
Wiedemann
M
M
M.E. Müller-Institute, University of Bern, P.O. Box 30, CH-3010, Bern, Switzerland.
Trueb
B
B
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D015723:Gene Library; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008969:Molecular Sequence Data; D051500:Receptor, Fibroblast Growth Factor, Type 5; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics*; D016415:Sequence Alignment
C417531:FGFRL1 protein, human; C496379:Fgfrl1 protein, mouse; D051500:Receptor, Fibroblast Growth Factor, Type 5; D017468:Receptors, Fibroblast Growth Factor