[Th effect of D2-dopamine receptor blockade on glutamate release into extracellular space of Nucleus accumbens during food reinforcement].
In Sprague-Dawley rats in was shown by means of in vivo microdialysis combined with HPLC-EC analysis that the blockade of D2-dopamine receptors of the n. accumbens by raclopride (10 microM) completely prevents a decrease in accumbal extracellular glutamate level induced by food intake.
Saul'skaia
N B
NB
Pavlov Institute of Physiology, Russian Academy of Sciences, St.-Petersburg.
Mikhaĭlova
M O
MO
D000818:Animals; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D005110:Extracellular Space / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism* / Q000502:physiology; D008297:Male; D009714:Nucleus Accumbens / Q000502:physiology*; D020891:Raclopride / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000502:physiology; D012054:Reinforcement, Psychology
D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2; D018698:Glutamic Acid; D020891:Raclopride