Oligomerization of 3'-amino-3'deoxyguanosine-5'phosphorimidazolidate on a d(CpCpCpCpC) template.
3'-Amino-3'-deoxyguanosine-5'-phosphorimidazolidate (ImpGNH2) oligomerizes more rapidly and regiospecifically than related nucleotide derivatives on a d(CpCpCpCpC) template.  The greater nucleophilicity of the amino group leads to efficient oligomerization even when the structure of the double-helical complex formed by the template and the substrate is not optimal for reaction.  The use of amine-containing analogues should permit us to develop models of potentially prebiotic polymerization reactions that cannot be studied easily using natural nucleotides.
Tohidi
M
M
The Salk Institute for Biological Studies, San Diego, California 92138, USA.
Zielinski
W S
WS
Chen
C H
CH
Orgel
L E
LE
D000588:Amines / Q000737:chemistry; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D019418:Evolution, Chemical; D019143:Evolution, Molecular; D006157:Guanosine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011066:Poly C / Q000737:chemistry*; D013698:Templates, Genetic
D000588:Amines; D009841:Oligonucleotides; D011066:Poly C; C036896:guanosine 5'-phospho-2-methylimidazolide; D006157:Guanosine Monophosphate; D003849:Deoxyguanosine