title: Clinical and angiographic effects of chronic calcium channel blocker therapy continued beyond first postoperative year in patients with radial artery grafts: results of a prospective randomized investigation.
abstract: BACKGROUND
  This study was conceived to elucidate the clinical and angiographic effects of chronic calcium channel blocker therapy (CCCBT) continued after the first postoperative year in patients in whom the radial artery (RA) was used for myocardial revascularization.
  
  
  RESULTS
  Patients who received RA grafts at our institution and who at 1 year had no scintigraphic evidence of ischemia in the RA territory or angiographic evidence of RA malfunction (n=120) were randomly assigned to continue (n=63) or suspend (n=57) the CCCBT with diltiazem (120 mg/d). After 5 years, all patients were reassessed clinically and by stress myocardial scintigraphy, and 87 of them (45 from the continued group that continued CCCBT and 42 from the group that suspended CCCBT) were restudied angiographically. No differences regarding either the clinical and scintigraphic results or the RA angiographic status were demonstrated between the 2 groups.
  
  
  CONCLUSIONS
  After the first postoperative year, the continuation of CCCBT does not affect RA graft patency or clinical and scintigraphic results.
authors.affiliation: Department of Cardiac Surgery, Catholic University, Rome, Italy. mgaudino@tiscalinet.it
authors.forename: M
authors.initials: M
authors.lastname: Gaudino
authors.forename: F
authors.initials: F
authors.lastname: Glieca
authors.forename: N
authors.initials: N
authors.lastname: Luciani
authors.forename: F
authors.initials: F
authors.lastname: Alessandrini
authors.forename: G
authors.initials: G
authors.lastname: Possati
mesh_terms: D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D001026:Coronary Artery Bypass / Q000379:methods; D003327:Coronary Disease / Q000188:drug therapy* / Q000601:surgery; D003329:Coronary Vasospasm / Q000517:prevention & control; D004110:Diltiazem / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D017534:Radial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000637:transplantation*; D011877:Radionuclide Imaging; D012701:Serotonin / Q000494:pharmacology; D013995:Time; D016896:Treatment Outcome; D014654:Vascular Patency / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D012701:Serotonin; D004110:Diltiazem