Computer simulation of initial events in the biochemical mechanisms of DNA damage.
Understanding the systematic and quantitative correlation between the physical events of energy deposition by ionizing radiation and the ensuing chemical and biochemical processes leading to DNA damage is one of the goals in radiation research.  Significant progress has been made toward achieving the stated goal by using theoretical modeling techniques.  These techniques are strongly dependent on computer simulation procedures.  A review of such techniques with details of various stages of simulation development, including a comparison with available experimental data, is presented in this article.
Chatterjee
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Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Holley
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D001483:Base Sequence; D002843:Chromatin / Q000502:physiology; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004249:DNA Damage / Q000502:physiology*; D004583:Electrons / Q000009:adverse effects; D017665:Hydroxyl Radical; D018499:Linear Energy Transfer / Q000502:physiology; D008954:Models, Biological; D009010:Monte Carlo Method; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods; D014867:Water / Q000737:chemistry
D002843:Chromatin; D014867:Water; D017665:Hydroxyl Radical; D004247:DNA