[Comparative study of the diagnostic value of new cholera eltor bacteriophages ctx+, ctx-, and KhDF-3, 4, and 5].
The comparative evaluation of the diagnostic value of new cholera eltor bacteriophages ctx+ and ctx-, as well as monophages X[symbol: see text]-3, 4, 5, demonstrated their high activity and specificity. Using of these bacteriophages epidemic potential of 95% Vibrio cholerae eltor strains ctx+ and 84.5% of V. cholerae eltor stains ctx- was determined. Commercial monophages X[symbol: see text]-3, 4, 5 were inferior to bacteriophages ctx+ and ctx- in their diagnostic value: only 55% of strains having gene ctxAB were found to be epidemically dangerous, i.e. 45% of strains capable of causing the disease were not detected. On the basis of the results obtained in this investigation cholera eltor bacteriophages ctx+ and ctx- were recommended for introduction into practical use, while further production of cholera diagnostic monophages X[symbol: see text]-3, 4, 5 was recommended to be stopped.
Saiapina
L V
LV
Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations, Moscow, Russia.
Anisimova
T I
TI
Adamova
G V
GV
Kasina
I V
IV
Ostroumova
N M
NM
Gracheva
I V
IV
Kazakova
E S
ES
Livanova
L F
LF
Mironova
N P
NP
Kudriakova
T A
TA
Batyrova
B A
BA
Omarova
K B
KB
Reznikov
Iu B
IuB
Plotnikov
O P
OP
Shchelkanova
E Iu
EIu
Malakhaeva
A N
AN
Korovkina
G I
GI
Smirnova
N I
NI
Noskov
A K
AK
Bushineva
E A
EA
D001434:Bacteriophage Typing / Q000379:methods; D012680:Sensitivity and Specificity; D014734:Vibrio cholerae / Q000145:classification* / Q000472:pathogenicity