Plasma fibronectin- and thrombospondin-adhesive molecules during acute attacks and attack-free periods of familial Mediterranean fever.
We assessed plasma concentrations of fibronectin (FN) and thrombospondin (TSP) during acute attacks and attack-free periods of patients with familial Mediterranean fever (FMF). Seven female and three male FMF patients (mean age 34+/-7 years) were enrolled in the study. Plasma samples were obtained during acute FMF attacks and after 3 months of freedom from attacks. Erythrocyte sedimentation rate, C-reactive protein, and white blood cell count were evaluated concurrently. Plasma levels of FN and TSP were assayed by enzyme-linked immunosorbent assay (ELISA). Both FN and TSP concentrations were found to increase during acute attacks. Levels of adhesive molecules decreased during attack-free periods (P < 0.05). Significant correlations were found between FN and TSP levels and the concentrations of acute-phase response indicators (P< 0.05). This study disclosed for the first time significantly higher increments in the plasma levels of FN and TSP during acute FMF attacks than in attack-free periods. Therefore, the two matrix glycoproteins may play precipitating and/or regulatory roles in the inflammatory processes of these attacks.
Ertenli
I
I
Department of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey.
Kiraz
S
S
Oztürk
M A
MA
Haznedaroglu
I C
IC
Celik
I
I
Kirazli
S
S
Calgüneri
M
M
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005353:Fibronectins / Q000032:analysis / Q000097:blood*; D006801:Humans; D008297:Male; D011336:Probability; D011446:Prospective Studies; D012008:Recurrence; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D019699:Thrombospondins / Q000097:blood*
D015415:Biomarkers; D005353:Fibronectins; D019699:Thrombospondins