[Molecular mechanisms of metabolic adaptation in pathological changed liver during toxic hepatitis ].
Possible molecular mechanisms underlying changes in catalytical properties of alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) were studied at toxic hepatitis. The development of toxic hepatitis is accompanied by significant changes in the activity of ADH and LDH assayed in subcellular fractions and kinetic characteristics of these enzymes. This can result in an increase cellular level of acetylaldehyde and lactate which promotes the development of liver cirrhosis.
Zimin
Iu V
IuV
Molecular Pathology Group, Research Institute of Traumatology and Orthopedics, Verkhne-Volzhskaya nab. 18, Nizhniy Novgorod 603155, Russia. yuzimin@mail.ru
Siatkin
S P
SP
Berezov
T T
TT
D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology* / Q000473:pathology; D002384:Catalysis; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000473:pathology; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D008297:Male; D051381:Rats
D000426:Alcohol Dehydrogenase; D007770:L-Lactate Dehydrogenase