Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation.
We report the case of a 46-year-old male who developed dermatomyositis and a sarcoid-like reaction in association with testicular relapse of multiple myeloma. The myositis progressed despite chemotherapy directed at the underlying malignant disorder and immunosuppressive treatment. There was, however, a dramatic and sustained response to high-dose chemotherapy and autologous peripheral blood stem cell transplantation which resulted in resolution of the myopathy and partial resolution of the sarcoid-like reaction. This case report highlights the potential of autologous stem cell transplantation as treatment for para-neoplastic disorders associated with haematological malignancies.
Chakraverty
R
R
Institute of Cancer Studies, University of Birmingham, Edgbaston, UK.
Rabin
N
N
Peggs
K
K
Robinson
S
S
Duncan
J R
JR
Yong
K
K
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003882:Dermatomyositis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000628:therapy; D012008:Recurrence; D012507:Sarcoidosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D013736:Testicular Neoplasms / Q000628:therapy; D016896:Treatment Outcome