Avian-to-mammal transmission of an avian rotavirus: analysis of its pathogenicity in a heterologous mouse model.
It has been suggested that group A avian rotaviruses can be transmitted to mammals, but there is no direct evidence that such viruses induce disease in mammals. Suckling mice were orally inoculated with two avian rotaviruses. A pigeon rotavirus, PO-13, was found to induce diarrhea, but a turkey rotavirus, Ty-3, did not. The diarrhea induced by PO-13 was dependent on the age of the mouse. In histopathological examinations, antigens of PO-13 were sporadically detected in absorptive cells in the ileum, and lesions were observed as ballooning degenerations of absorptive cells in a region from the duodenum to the ileum. However, the rotavirus antigen was not detected in the majority of these degenerative cells. These results indicated that PO-13 could infect and induce diarrhea in suckling mice. This is the first evidence of an avian rotavirus being experimentally transmissible to a mammal.
Mori
Y
Y
Department of Veterinary Public Health, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Sugiyama
M
M
Takayama
M
M
Atoji
Y
Y
Masegi
T
T
Minamoto
N
N
D000818:Animals; D000833:Animals, Suckling; D000914:Antibodies, Viral / Q000097:blood; D010856:Columbidae / Q000821:virology*; D003967:Diarrhea / Q000821:virology; D004195:Disease Models, Animal; D007583:Jejunum / Q000821:virology; D008322:Mammals; D051379:Mice; D008815:Mice, Inbred Strains; D008871:Microvilli / Q000821:virology; D012401:Rotavirus / Q000254:growth & development / Q000472:pathogenicity* / Q000502:physiology*; D012400:Rotavirus Infections / Q000473:pathology / Q000503:physiopathology / Q000635:transmission*; D013997:Time Factors; D014422:Turkeys / Q000821:virology*; D014779:Virus Replication
D000914:Antibodies, Viral