Integrated regulation in response to simulated weightlessness.
To investigate physiological effects of tail suspension, Ca2+ concentration, immune factors, erythrocyte rheological properties, and growth hormone were determined in rats suspended for 15 and 30 d. The results showed that inhibitory changes of both local factors (proteins secreted by bone cell, Ca(2+)-ATPase in sarcoplasmic reticium) and integrated regulative factors (immune factor, growth hormone) were observed simultaneously with the decrease of bone mineral content, calcium transportation in skeletal muscles as well as erythrocyte deformability. It suggests that both local and integrated regulative processes are functioning in response to the effects of weightlessness.
Yang
G
G
Institute of Space Medico-Engineering, Beijing, China.
Cui
W
W
Sun
Y
Y
Dong
Q
Q
Shen
X
X
Wang
T
T
D000818:Animals; D015519:Bone Density / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004907:Erythrocyte Deformability / Q000502:physiology; D004912:Erythrocytes / Q000648:ultrastructure*; D019417:Hindlimb Suspension / Q000009:adverse effects*; D006728:Hormones / Q000378:metabolism; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism*; D010006:Osteoblasts / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018474:Weightlessness Simulation
D006728:Hormones; D000252:Calcium-Transporting ATPases; D002118:Calcium