title: Depression scores following migraine treatment in patients attending a specialized center for headache and neurology.
abstract: OBJECTIVE
  To determine the changes in clinical characteristics and depression levels among patients following treatment for migraine.
  
  
  BACKGROUND
  Epidemiologic studies have provided consistent evidence regarding an association between migraine and depression. In Puerto Rico, however, migraine has not yet been systematically investigated.
  
  
  METHODS
  A chart review of 144 Puerto Rican patients who presented with migraine, diagnosed according to the International Headache Society criteria, and depression over a 2-year period was performed. The level of depression, before and after migraine treatment, was evaluated using the Zung Self-rating Depression Scale.
  
  
  RESULTS
  The mean age of patients was 37.0 +/- 14.4 years; 77.1% were women. More than half (52.8%) reported severe headache and 56.9% reported a monthly frequency of five attacks or more. Nearly 9% were using antidepressant therapy and 8% were under psychiatric treatment. The mean Zung index score at baseline was 50.6 +/- 10.9. Following treatment with triptans, the intensity and frequency of migraine and the Zung index score decreased significantly (P<.00001). A trend for a greater reduction in Zung index scores among patients receiving triptan medications for more than a year was demonstrated (P =.07).
  
  
  CONCLUSIONS
  These results indicate that migraine treatment with triptans appears to be effective in decreasing the headache frequency and intensity, and depression levels, independent of antidepressant medication use or psychiatric treatment.
authors.affiliation: Specialized Headache Management and Neurology Center, San Francisco Hospital, San Juan, Puerto Rico, USA.
authors.forename: H
authors.initials: H
authors.lastname: Miranda
authors.forename: G
authors.initials: G
authors.lastname: Ortiz
authors.forename: S
authors.initials: S
authors.lastname: Figueroa
authors.forename: C M
authors.initials: CM
authors.lastname: Pérez
authors.forename: E
authors.initials: E
authors.lastname: Suárez
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy / Q000209:etiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D017366:Serotonin Receptor Agonists