Present trends and future strategy in chemotherapy of malaria.
This review starts from a brief introduction followed by the list of commercial antimalarial drug. According to the nature of chemical entities, these drugs have been divided into the following categories--Quinolines, pyrimidines, amidinies, guanidines, sulfonamides, sulfones, acridines, antibiotics and sesquiterpene lactones. The site of action and status of the antimalarial drugs have been described against each category. A brief description of reasons behind the search of a new antimalarial drug have been discussed. Finally, the review deals the well known biochemical target sites such as folate metabolism, pyrimidine metabolism and polyamines for the designing of antimalarial drugs. The detail description of the newly discovered biochemical target sites, alpha-tublin and DNA topoisomerases, have been highlighted. In the conclusion section, we have discussed the future strategies for the chemotherapy of malaria.
Chauhan
P M
PM
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, 226001, India. prem_chauhan_2000@yahoo.com
Srivastava
S K
SK
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D026942:DNA Topoisomerases / Q000378:metabolism; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use; D011796:Quinacrine / Q000627:therapeutic use; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use; D059003:Topoisomerase Inhibitors
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D011743:Pyrimidines; D013449:Sulfonamides; D059003:Topoisomerase Inhibitors; D026942:DNA Topoisomerases; D011796:Quinacrine