Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization.
Hexitol nucleic acids (HNAs) are DNA analogues that contain the standard nucleoside bases attached to a phosphorylated 1,5-anhydrohexitol backbone. We find that HNAs support efficient information transfer in nonensymatic template-directed reactions. HNA heterosequences appeared to be superior to the corresponding DNA heterosequences in facilitating synthesis of complementary oligonucleotides from nucleoside-5'-phosphoro-2-methyl imidazolides.
Kozlov
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IA
The Salk Institute for Biological Studies, San Diego, California 92186, USA.
De Bouvere
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B
Van Aerschot
A
A
Herdewijn
P
P
Orgel
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D002851:Chromatography, High Pressure Liquid; D004247:DNA; D019020:Directed Molecular Evolution; D019143:Evolution, Molecular; D006157:Guanosine Monophosphate / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D009696:Nucleic Acids / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D012313:RNA / Q000737:chemistry*; D013402:Sugar Alcohols / Q000737:chemistry; D013698:Templates, Genetic
D009696:Nucleic Acids; D009705:Nucleosides; D009841:Oligonucleotides; D011108:Polymers; D013402:Sugar Alcohols; D012313:RNA; C036896:guanosine 5'-phospho-2-methylimidazolide; D006157:Guanosine Monophosphate; D004247:DNA