title: Quantitation of heavy ion damage to the mammalian brain:  some preliminary findings.
abstract: Histological preparations of brains from rabbits and mice exposed to different doses of various HZE particles or to low-LET photons have been subjected to preliminary quantitation of radiation-induced morphometric changes.  Computer assisted measurements of several brain structures and cell types have been made using the KONTRON Automated Interactive Measurement System (IBAS, Carl Zeiss, Inc., Thornwood, N.Y. 10594 U.S.A.).  New Zealand white rabbits irradiated at approximately 6 weeks of age were euthanatized 6.5-25 months after exposure to 60Co gamma photons (LET infinity = approximately 0.3 keV/micrometer, 20Ne particles (LET infinity = 35 +/- 3 keV/micrometer), or 40Ar particles (LET infinity = 90 +/- 5 keV/micrometer).  Measurements of stained sections of the olfactory bulbs of those animals indicate that the mean size (volume) of olfactory glomeruli is reduced in a dose-dependent (and perhaps an LET-dependent) manner as soon as 6.5 months after irradiation.  Differences between mean volumes of additional structures have been noted when histological preparations of control mouse brains were compared with irradiated specimens.  Quantitation of intermediate and late changes in nervous (and other) tissues exposed to low- and high-LET radiations will improve our ability to predict late effects in tissues of astronauts and others exposed to the radiation hazards of the space environment.
authors.affiliation: Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Cox
authors.forename: L M
authors.initials: LM
authors.lastname: Kraft
mesh_terms: D000818:Animals; D001128:Argon; D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D003035:Cobalt; D003359:Cosmic Radiation / Q000009:adverse effects*; D005720:Gamma Rays; D007091:Image Processing, Computer-Assisted; D018499:Linear Energy Transfer; D051379:Mice; D009356:Neon; D009830:Olfactory Bulb / Q000473:pathology* / Q000528:radiation effects*; D010315:Particle Accelerators; D017785:Photons; D011817:Rabbits
chemical_list: D003035:Cobalt; D009356:Neon; D001128:Argon