title: msh specifies dorsal cell fate in the Drosophila wing.
abstract: Drosophila limbs develop from imaginal discs that are subdivided into compartments. Dorsal-ventral subdivision of the wing imaginal disc depends on apterous activity in dorsal cells. Apterous protein is expressed in dorsal cells and is responsible for (1) induction of a signaling center along the dorsal-ventral compartment boundary (2) establishment of a lineage restriction boundary between compartments and (3) specification of dorsal cell fate. Here, we report that the homeobox gene msh (muscle segment homeobox) acts downstream of apterous to confer dorsal identity in wing development.
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Milán
authors.forename: U
authors.initials: U
authors.lastname: Weihe
authors.forename: S
authors.initials: S
authors.lastname: Tiong
authors.forename: W
authors.initials: W
authors.lastname: Bender
authors.forename: S M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D000483:Alleles; D000818:Animals; D019521:Body Patterning / Q000502:physiology; D002454:Cell Differentiation; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D060850:LIM-Homeodomain Proteins; D016296:Mutagenesis; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014921:Wings, Animal / Q000166:cytology / Q000254:growth & development
chemical_list: C096010:Dr protein, Drosophila; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; D060850:LIM-Homeodomain Proteins; D014157:Transcription Factors; C074459:ap protein, Drosophila