[Regulation of the functional state of mediastinal pleural mast cells by adrenergic agents].
The adrenoactivity of the mast cells (MC) in the albino rats mediastinal pleura was studied during the experiment with the use of the pharmacological preparations of adrenergic effect in vivo and in vitro. While injecting adrenolytics and adrenomimetics presence of heparin and biogenic monoamines (catecholamines and serotonin) was observed. Adrenomimetic substances in vivo and in vitro were observed to intensify the synthetic process, decrease degranulation, concentrate the density of heparin granules and increase the number of biogenic monoamines while adrenolytic substances were noticed to produce contrary effect.
Eliseeva
E V
EV
Department of Histology, State Medical University of Vladivostok.
D018663:Adrenergic Agents / Q000494:pharmacology*; D000322:Adrenergic Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008482:Mediastinum; D010994:Pleura / Q000166:cytology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D018663:Adrenergic Agents; D000322:Adrenergic Agonists; D000319:Adrenergic beta-Antagonists; D015306:Biogenic Monoamines; D012701:Serotonin; D011433:Propranolol; D004837:Epinephrine