Experimental models to investigate the pathology of antisperm antibodies: approaches and problems.
Antisperm antibodies (ASA) can interfere with sperm function and fertilization. But we still know relatively little about the specific mechanisms that elicit an auto-immune response and we have a poor appreciation of the profile of ASA that lead to antibody-mediated infertility in the male. This brief review explores some of the experimental models, the current approaches and the problems associated with investigations of ASA.
Clayton
R
R
Department of Molecular Biology & Biotechnology, University of Sheffield, UK
Moore
H
H
D000818:Animals; D001323:Autoantibodies / Q000502:physiology*; D004195:Disease Models, Animal; D005306:Fertilization; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000276:immunology*
D001323:Autoantibodies