[Preclinical toxicological study of D-glucuronic acid].
A new D-glucuronic acid (DGA) preparation was studied for toxicological safety on a preclinical level. The results obtained upon a single acute DGA administration in rats, mice, and rabbis showed that the drug exhibits moderate toxicity. A one-month treatment of rats (at a single daily dose of 50, 250, and 500 mg/kg, i.p.) and dogs (50 mg/kg, i.v.) induced neither functional nor morphological changes in hemopoietic and lymphoid organs, kidney, heart, as well as in the digestive, nervous, hemostatic, and fibrinolytic systems. The intraperitoneal administration of DGA produced a pronounced local irritation effects. The liver of both rats and dogs treated with DGA showed dose-dependent adipose degeneration, which decreased upon the drug abolition. The administration of DGA in 50, 100, and 250 mg/kg doses led to dose-dependent changes in some characteristics of the reproductive system in rats. DGA did not modify the extent of allergic reactions and showed no immunotoxicant and mutagen properties.
Karpova
G V
GV
Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Fomina
T I
TI
Vetoshkina
T V
TV
Borovskaia
T G
TG
Voronova
O L
OL
Dubskaia
T Iu
TIu
Udut
V V
VV
Khlusova
M Iu
MIu
D000818:Animals; D000917:Antibody Formation; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000209:etiology; D007111:Immunity, Cellular / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009152:Mutagenicity Tests; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D023382:Toxicity Tests, Acute
D020723:Glucuronic Acid