title: Efficacy of combined technetium-99m sulfur colloid/indium-111 leukocyte scans to detect infected total hip and knee arthroplasties.
abstract: The reliability of combined indium-111 leukocyte/technetium-99m sulfur colloid scans, with and without the addition of blood pooling and blood flow studies, in the diagnosis of infected total joint arthroplasty was investigated. Both scans were performed on 58 patients before reoperation of total hip or knee arthroplasty in the period 1996-1999. Results for imaging alone included 100% specificity, 46% sensitivity, 100% positive predictive value, 84% negative predictive value, and 88% accuracy. Inclusion of blood pooling and flow phase data improved results to 66% sensitivity, 89% negative predictive value, and 90% accuracy, with reductions in specificity (98%) and positive predictive value (91%). Routine use of these radionuclide scans is not supported by these data.
authors.affiliation: Musculoskeletal Research Center, Department of Orthopaedic Surgery, NYU-Hospital for Joint Diseases, New York, New York 10003, USA.
authors.forename: T N
authors.initials: TN
authors.lastname: Joseph
authors.forename: M
authors.initials: M
authors.lastname: Mujtaba
authors.forename: A L
authors.initials: AL
authors.lastname: Chen
authors.forename: S L
authors.initials: SL
authors.lastname: Maurer
authors.forename: J D
authors.initials: JD
authors.lastname: Zuckerman
authors.forename: C
authors.initials: C
authors.lastname: Maldjian
authors.forename: P E
authors.initials: PE
authors.lastname: Di Cesare
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007205:Indium Radioisotopes; D007720:Knee Prosthesis; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging* / Q000601:surgery; D011877:Radionuclide Imaging; D012086:Reoperation; D012680:Sensitivity and Specificity; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D007205:Indium Radioisotopes; D013671:Technetium Tc 99m Sulfur Colloid