title: Ophthalmic surgery in haemophilia.
abstract: A wide range of ophthalmic surgical procedures were conducted in five patients with haemophilia of varying severity (one severe and four mild) aged between 8 and 75 years. The operations included intraocular lens implantation, trabeculectomy and vitrectomy. Successful postoperative outcome with haemostasis was achieved in all patients with moderate use of clotting factor concentrates (3000-7000 IU), simultaneous use of oral epsilon amino caproic acid therapy and intravenous deamino-8-D-arginine vasopressin (desmopressin; DDAVP) wherever feasible. None of the patients had circulating inhibitor. One of the patients with milder disease (FVIII 32%) was referred to us after he was operated on for hyphaema elsewhere, without prior knowledge of his diagnosis of haemophilia. Thus, satisfactory eye surgery in patients with haemophilia is possible with a restricted amount of factor concentrates with gratifying results.
authors.affiliation: JC Patel Department of Haematology, KEM Hospital, Mumbai, India.
authors.forename: F
authors.initials: F
authors.lastname: Jijina
authors.forename: K
authors.initials: K
authors.lastname: Ghosh
authors.forename: M
authors.initials: M
authors.lastname: Madkaikar
authors.forename: D
authors.initials: D
authors.lastname: Mohanty
mesh_terms: D000368:Aged; D015119:Aminocaproic Acid / Q000008:administration & dosage; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D005164:Factor IX / Q000008:administration & dosage; D005169:Factor VIII / Q000008:administration & dosage; D006467:Hemophilia A / Q000188:drug therapy / Q000601:surgery*; D006487:Hemostasis; D006490:Hemostatics / Q000008:administration & dosage; D006801:Humans; D007908:Lens, Crystalline / Q000637:transplantation; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D014130:Trabeculectomy; D014821:Vitrectomy
chemical_list: D006490:Hemostatics; D005169:Factor VIII; D005164:Factor IX; D003894:Deamino Arginine Vasopressin; D015119:Aminocaproic Acid