title: Nemaline rod and degeneration of Z band of muscle cell in weightlessness at spaceflight.
abstract: There are some studies demonstrating the skeletal muscle degeneration associated with the degeneration of Z band and appearance of nemaline rods in experimental animals of the simulation model for spaceflight but not in human heart tissues. In the present study, therefore, we investigated the pathological changes or degeneration in left auricular heart muscles obtained during operations of mitral valves replacement using both electron and light microscopies. The degeneration of Z band even in the myofibrils of comparatively little damaged cell was found. Furthermore, nemaline rods were detected in most of the heart muscle cells. These results suggest that the existence of nemaline rods is involved in the cell injury in the heart muscle of patients with heart disease without nemaline myopathy. Further study is necessary to know whether the similar pathological findings are observed not only in the skeletal muscle but also in the cardiac muscle in experimental animals of the simulation model for spaceflight or in a prolonged spaceflight.
authors.affiliation: Kagoshima University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Imuta
authors.forename: I
authors.initials: I
authors.lastname: Higuchi
mesh_terms: D000818:Animals; D005347:Fibroblasts / Q000648:ultrastructure; D006349:Heart Valve Diseases / Q000473:pathology; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008854:Microscopy, Electron; D008943:Mitral Valve / Q000601:surgery; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000473:pathology / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000166:cytology / Q000473:pathology* / Q000648:ultrastructure*; D009206:Myocardium / Q000166:cytology / Q000473:pathology* / Q000648:ultrastructure*; D009210:Myofibrils / Q000473:pathology / Q000648:ultrastructure; D017696:Myopathies, Nemaline / Q000473:pathology*; D018474:Weightlessness Simulation