title: Epileptic seizures after treatment with thiocolchicoside.
abstract: OBJECTIVE
  To report the occurrence of epileptic seizures in humans, closely related to the use of the centrally acting muscle relaxant thiocolchicoside.
  
  
  METHODS
  Description of three case histories.
  
  
  RESULTS
  Two patients, affected with complex-partial seizures, sometimes secondarily generalized, receiving antiepileptic therapy, were seizure free for 7 and 9 years, respectively. They had the reappearance of tonic-clonic seizures few days after the continued use of thiocolchicoside, at a cumulative dose of the drug of 52 mg and 76 mg, respectively. The third patient was brain damaged and without a history of seizures. He had a sudden, convulsive seizure a few minutes after 4 mg intramuscular thiocolchicoside.
  
  
  CONCLUSIONS
  Our case histories indicate that thiocolchicoside has a powerful epileptogenic activity. This drug should be avoided in patients with epilepsy or acute brain injury and possible disruption of the blood-brain barrier.
authors.affiliation: Department of Traumatology, Orthopedics and Occupational Health, University of Torino, Torino, Italy.
authors.forename: P L
authors.initials: PL
authors.lastname: De Riu
authors.forename: G
authors.initials: G
authors.lastname: Rosati
authors.forename: S
authors.initials: S
authors.lastname: Sotgiu
authors.forename: G
authors.initials: G
authors.lastname: Sechi
mesh_terms: D000328:Adult; D001812:Blood-Brain Barrier; D001921:Brain / Q000000981:diagnostic imaging; D001930:Brain Injuries / Q000000981:diagnostic imaging / Q000453:epidemiology; D003078:Colchicine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000453:epidemiology; D014057:Tomography, X-Ray Computed
chemical_list: D003078:Colchicine; C004280:thiocolchicoside