title: Intrapartum zidovudine infusion alone failed to reduce both maternal HIV-1 viral load and HIV-1 infection in infant.
abstract: A pilot clinical trial to assess the efficacy of intrapartum zidovudine (ZDV) infusion alone in the reduction of maternal viral load and its potential role in preventing vertical transmission of HIV-1. Twenty six, asymptomatic antiretroviral naïve HIV-1 infected pregnant women who had no prior antenatal care and were in labor were enrolled. Each patient received ZDV infusion at the rate of 2 mg/kg within the first hour. ZDV was then continuously infused at 1 mg/kg/h until delivery. Maternal plasma HIV-1 RNA prior to the commencement of ZDV infusion and within an hour after delivery were measured. HIV-1 transmission was documented by nested polymerase chain reaction in infants at six months of age. Median maternal plasma HIV-1 RNA prior to the ZDV infusion and after delivery was 29,401 and 32,555 copies/ml respectively, (p>0.05). The estimated HIV-1 transmission rate was 19.2 per cent (95% CI = 4-34). This result suggested that in asymptomatic HIV-1 infected pregnant women who were antiretroviral naïve and had no prior antenatal care, intrapartum ZDV infusion alone failed to reduce maternal HIV-1 viremia and the transmission rate of HIV-1.
authors.affiliation: Department of Obstetrics and Gynecology, Chulalongkorn University, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Limpongsanurak
authors.forename: P
authors.initials: P
authors.lastname: Thaithumyanon
authors.forename: U
authors.initials: U
authors.lastname: Thisyakorn
authors.forename: K
authors.initials: K
authors.lastname: Ruxrungtham
authors.forename: S
authors.initials: S
authors.lastname: Chaithongwongwatthana
authors.forename: P
authors.initials: P
authors.lastname: Kongsin
authors.forename: U
authors.initials: U
authors.lastname: Tarounotai
authors.forename: N
authors.initials: N
authors.lastname: Chantheptaewan
authors.forename: T
authors.initials: T
authors.lastname: Triratwerapong
authors.forename: S
authors.initials: S
authors.lastname: Ubolyam
authors.forename: P
authors.initials: P
authors.lastname: Phanuphak
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D007262:Infusions, Intravenous; D010865:Pilot Projects; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000517:prevention & control*; D011256:Pregnancy Outcome; D012367:RNA, Viral / Q000097:blood; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D019562:Viral Load; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral; D015215:Zidovudine