title: Towards NeuroML: model description methods for collaborative modelling in neuroscience.
abstract: Biological nervous systems and the mechanisms underlying their operation exhibit astonishing complexity. Computational models of these systems have been correspondingly complex. As these models become ever more sophisticated, they become increasingly difficult to define, comprehend, manage and communicate. Consequently, for scientific understanding of biological nervous systems to progress, it is crucial for modellers to have software tools that support discussion, development and exchange of computational models. We describe methodologies that focus on these tasks, improving the ability of neuroscientists to engage in the modelling process. We report our findings on the requirements for these tools and discuss the use of declarative forms of model description--equivalent to object-oriented classes and database schema--which we call templates. We introduce NeuroML, a mark-up language for the neurosciences which is defined syntactically using templates, and its specific component intended as a common format for communication between modelling-related tools. Finally, we propose a template hierarchy for this modelling component of NeuroML, sufficient for describing models ranging in structural levels from neuron cell membranes to neural networks. These templates support both a framework for user-level interaction with models, and a high-performance framework for efficient simulation of the models.
authors.affiliation: Institute for Adaptive and Neural Computation, Division of Informatics, University of Edinburgh, 5 Forrest Hill, Edinburgh EH1 2QL, Scotland. nigel.goddard@ed.ac.uk
authors.forename: N H
authors.initials: NH
authors.lastname: Goddard
authors.forename: M
authors.initials: M
authors.lastname: Hucka
authors.forename: F
authors.initials: F
authors.lastname: Howell
authors.forename: H
authors.initials: H
authors.lastname: Cornelis
authors.forename: K
authors.initials: K
authors.lastname: Shankar
authors.forename: D
authors.initials: D
authors.lastname: Beeman
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003299:Cooperative Behavior; D006801:Humans; D008959:Models, Neurological; D009488:Neurosciences / Q000379:methods*; D012984:Software