Antiinflammatory effect of russian-made budesonide in experimental noninfectious pulmonary granulomatosis.
We studied the antiinflammatory effect of a Russian-made glucocorticoid budesonide administered by inhalation and intraperitoneal injection to rats with experimental noninfectious pulmonary granulomatosis. The antiinflammatory effects of budesonide at both administration routes were similar. Intraperitoneal injection, in contrast to inhalation, produced a systemic effect manifested in suppression of hyperplasia of non-encapsulated lymphoid formations in the mucosa.
Sladkopevtsev
A S
AS
Laboratory of Inflammation Immunomorphology, Institute of Human Morphology, Russian Academy of Medical Sciences.
Mikhailova
L P
LP
Makarova
O V
OV
Kovaleva
V L
VL
Veselova
N I
NI
D000280:Administration, Inhalation; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid; D019819:Budesonide / Q000627:therapeutic use*; D006965:Hyperplasia / Q000188:drug therapy; D007263:Infusions, Parenteral; D008168:Lung / Q000187:drug effects; D008230:Lymphomatoid Granulomatosis / Q000188:drug therapy*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D019819:Budesonide