Self major histocompatibility complex class-II-specific regulatory CD4 T cells prevent both Th1- and Th2-mediated autoimmune diseases in the rat.
It is clear that functional heterogeneity of T cells may be explained by differential cytokine production. The aim of this paper was to review evidence for regulatory cells, generated after HgCl(2)-exposure. They differ from classical Th1 and Th2 cells, produce transforming growth factor-beta and interleukin-10 and exert their regulatory functions in a Th1/Th2-unrestricted fashion.
Pelletier
L
L
Inserm U28, Hôpital Purpan, place du D Baylac, 31059, Toulouse, France. Lucette.Pelletier@purpan.inserm.fr
Savignac
M
M
Xystrakis
E
E
Duplan
V
V
Druet
P
P
Abdelhadi
S
S
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000503:physiopathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015536:Down-Regulation; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008627:Mercuric Chloride / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D008627:Mercuric Chloride