title: Tubulointerstitial nephritis and uveitis syndrome in two siblings.
abstract: Two Japanese sisters with persistent uveitis showed significant increased levels of urinary beta-2 microglobulin. A percutaneous renal biopsy performed in the younger sister revealed tubulointerstitial nephritis (TIN) with helper/inducer T cell infiltrates. Also, abnormal 67-gallium accumulation in the kidneys, suggesting TIN, was observed in the other one at the same time. Although patients with the syndrome of tubulointerstitial nephritis and uveitis (TINU) have been reported to date, its occurrence in siblings has rarely been seen. Both of them shared same human leukocyte antigen (HLA) DR6, suggesting the potential association between HLA-DR6 and TINU.
authors.affiliation: Department of Pediatrics, Hirosaki University School of Medicine, Japan. hirotana@cc.hirosaki-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Waga
authors.forename: T
authors.initials: T
authors.lastname: Nakahata
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: N
authors.initials: N
authors.lastname: Onodera
authors.forename: S
authors.initials: S
authors.lastname: Iwami
authors.forename: N
authors.initials: N
authors.lastname: Monma
authors.forename: E
authors.initials: E
authors.lastname: Ito
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D015808:HLA-DR6 Antigen / Q000276:immunology*; D006801:Humans; D009395:Nephritis, Interstitial / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D009679:Nuclear Family; D014605:Uveitis / Q000276:immunology* / Q000503:physiopathology
chemical_list: D015808:HLA-DR6 Antigen