title: Cataract analysis and the assessment of radiation risk in space.
abstract: Radiation cataract, a non-stochastic effect on the lens, is readily amenable to non-invasive analysis. Thus, it provides the means to assess radiation risk in space and for long-term monitoring of those who frequent that environment. The importance of such evaluations are underscored by the uncertainties associated with the assignment of quality factors for the effects of heavy charged particles constituting cosmic and solar radiation. Experimental studies were conducted using albino rats to evaluate the cataractogenic potential of 570 MeV/amu Argon ions administered as both single and protracted doses. The cataract studies and investigations of quantitative cytopathological changes associated with them indicate that as the dose of heavy particles decreases, the relative biological effectiveness, compared to X rays, increases. Fractionating the exposures not only failed to reduce the cataractogenic effect but caused a dose-dependent enhancement in the time of onset of opacification. Cytopathologically, the damage caused by heavy particles, when compared to low-LET radiation was found to be quantitatively dissimilar but qualitatively identical. In addition, damage which might be consistent with microlesions was not evident. The data indicates that as regards the cataractogenic potential of heavy particles at low doses an assignment of a Quality Factor (QF) of at least 40 may be in order.
authors.affiliation: Department of Ophthalmology, Columbia University, New York 10032, USA.
authors.forename: B V
authors.initials: BV
authors.lastname: Worgul
mesh_terms: D000818:Animals; D001128:Argon; D002386:Cataract / Q000145:classification / Q000209:etiology* / Q000473:pathology*; D004307:Dose-Response Relationship, Radiation; D005118:Extraterrestrial Environment; D020450:Heavy Ions; D006801:Humans; D007908:Lens, Crystalline / Q000473:pathology / Q000528:radiation effects*; D051379:Mice; D009502:Neutrons; D010315:Particle Accelerators; D011833:Radiation Injuries, Experimental; D051381:Rats; D011919:Rats, Inbred Strains; D012062:Relative Biological Effectiveness; D018570:Risk Assessment; D013026:Space Flight
chemical_list: D001128:Argon