Influence of simulated microgravity on the exercise performance of Fischer 344 rats.
Measurements from mission specialists after space flights or from subjects subjected to head down tilt experiments have demonstrated a decrease in exercise performance.  Similar decreases have been reported for rats that have participated in simulated microgravity studies using the head down-tail suspended method of Morey-Holton (HDS).  Because it is unclear whether older animal populations would exhibit similar responses, we undertook a HDS study with Fischer 344 male rats.
Tipton
C M
CM
Exercise & Sport Sciences, The University of Arizona, Tucson 85721, USA.
Sebastian
L A
LA
Edwards
P K
PK
Moran
M M
MM
D000375:Aging; D000818:Animals; D001831:Body Temperature / Q000502:physiology; D001835:Body Weight; D005080:Exercise Test; D018475:Head-Down Tilt; D006614:Hindlimb; D007103:Immobilization / Q000009:adverse effects*; D007668:Kidney / Q000033:anatomy & histology; D008297:Male; D009929:Organ Size; D010101:Oxygen Consumption; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D013737:Testis / Q000473:pathology; D018474:Weightlessness Simulation