[Phytin efficacy in correction of the impaired detoxication liver function in the long-term compression syndrome in rats in prepubertal period].
The compression syndrome was reproduced in rats aged one month and the efficacy of phytin in correcting the activity infringement and restoring the content of basic components of the hepatocyte monooxygenase enzyme system was studied in the postcompression period. The compression led to pronounced inhibition of the activity of aniline hydroxylase and amidopyrine M-demethylase, reduced the content of liver microsomal protein and cytochromes P-450 and b5, and increased the level of medium- molecular-weight (MMW) peptides in the blood serum. A six-day treatment with phytin restored the normal level of the liver monooxygenase system components and MMW peptides. Phytin reduced the level of lactic acid (LA) and increased that of pyruvic acid (PA) in liver tissues, which led to a sharp drop in the LA/MA ratio indicative of a decrease in the extent of hypoxia.
Rakhmatullaev
F Kh
FKh
Central Research Laboratory, Second State Medical Institute, ul Farobi 2, Tashkent, 700109 Uzbekistan.
Khakimov
Z Z
ZZ
D000375:Aging / Q000378:metabolism; D000818:Animals; D003444:Crush Syndrome / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology; D010833:Phytic Acid / Q000627:therapeutic use*; D051381:Rats
D010833:Phytic Acid