title: [Effects of freezing and hypoxia on serum creatine kinase activity in rats].
abstract: Serum creatine kinase (CK) activity after cold exposure in rats acclimated to cold, hypoxia, or combined factors (both cold and hypoxia) were observed under normoxic [correction of normoxie] and hypoxic condition in order to study the degrees of damage to the tissues. The results showed that resistance to frostbite increased in rats acclimated to cold; resistance to frostbite decreased markedly in rats acclimated to hypoxia, i.e. negative cross-acclimation exists between hypoxia and cold. The changes in serum CK activity in rats exposed to both cold and hypoxia for 4 weeks were essentially the same as those in hypoxia-acclimated rats, and were different significantly from those in cold-acclimated rats. It indicates that the effects of hypoxic exposure were stronger than those of cold exposure, its mechanism remains an area for further study.
authors.affiliation: Institute of Hygiene and Environmental Medicine, Academy of Military Medical Sciences, Tianjin, China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
authors.forename: F
authors.initials: F
authors.lastname: Li
authors.forename: P
authors.initials: P
authors.lastname: Yan
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000222:Adaptation, Physiological; D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood* / Q000378:metabolism; D005627:Frostbite; D007036:Hypothermia, Induced / Q000009:adverse effects; D000860:Hypoxia / Q000503:physiopathology*; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003402:Creatine Kinase; D010100:Oxygen