title: 6-azacytidine--compound with wide spectrum of antiviral activity.
abstract: 6-azacytidine demonstrates activity against adenoviruses types 1, 2, 5. It inhibit synthesis of viral DNA and proteins. 6-AC shows antiherpetic and antiinfluenza action during experimental infection in mice. 6-AC is prospective for drug development as an antiviral substance with a wide spectrum of activity.
authors.affiliation: Institute of Molecular Biology and Genetics, Kyiv, Ukraine.
authors.forename: I
authors.initials: I
authors.lastname: Alexeeva
authors.forename: N
authors.initials: N
authors.lastname: Dyachenko
authors.forename: L
authors.initials: L
authors.lastname: Nosach
authors.forename: V
authors.initials: V
authors.lastname: Zhovnovataya
authors.forename: S
authors.initials: S
authors.lastname: Rybalko
authors.forename: R
authors.initials: R
authors.lastname: Lozitskaya
authors.forename: A
authors.initials: A
authors.lastname: Fedchuk
authors.forename: V
authors.initials: V
authors.lastname: Lozitsky
authors.forename: T
authors.initials: T
authors.lastname: Gridina
authors.forename: A
authors.initials: A
authors.lastname: Shalamay
authors.forename: L
authors.initials: L
authors.lastname: Palchikovskaja
authors.forename: O
authors.initials: O
authors.lastname: Povnitsa
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001374:Azacitidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D020803:Encephalitis, Herpes Simplex / Q000188:drug therapy; D006367:HeLa Cells; D006561:Herpes Simplex / Q000188:drug therapy; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy; D051379:Mice
chemical_list: D000998:Antiviral Agents; D001374:Azacitidine; C040881:6-azacytidine