title: Cytogenetic investigations in flight personnel.
abstract: During long-distance flights at high altitudes flight personnel are exposed to cosmic radiation. In order to determine whether there are biological effects of such low dose radiation exposure in aircrew, chromosomal aberrations were investigated in 59 female cabin attendants and a matched control group of 31 members of station personnel. The mean number of dicentric chromosomes amounts to 1.3 (95% CI 1.0-1.6) per 1000 cells in cabin attendants and 1.4 (95% CI 1.0-1.9) per 1000 cells in controls. In an additional control group of 56 female clerks from Berlin the mean frequency of dicentric chromosomes was 1.3 (95% CI 1.0-1.6). Neither in dicentric frequency and distribution nor in other aberrations was a significant difference between the groups of flight and station personnel found. The high frequency of multi-aberrant cells was remarkable in flight personnel as well as in station personnel. The reason for this phenomenon is unknown and needs further investigation.
authors.affiliation: Robert Koch Institute Berlin, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Wolf
authors.forename: G
authors.initials: G
authors.lastname: Obe
authors.forename: L
authors.initials: L
authors.lastname: Bergau
mesh_terms: D000328:Adult; D000337:Aerospace Medicine; D000531:Altitude; D001359:Aviation; D002869:Chromosome Aberrations / Q000502:physiology*; D003359:Cosmic Radiation; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008875:Middle Aged; D016273:Occupational Exposure; D011829:Radiation Dosage; D012854:Sister Chromatid Exchange / Q000528:radiation effects