title: Genome of the bacterium Streptococcus pneumoniae strain R6.
abstract: Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because the R6 strain is avirulent and, more importantly, because it is readily transformed with DNA from homologous species and many heterologous species, it is the principal platform for investigation of the biology of this important pathogen. It is also used as a primary vehicle for genomics-based development of antibiotics for gram-positive bacteria. In our analysis of the genome, we identified a large number of new uncharacterized genes predicted to encode proteins that either reside on the surface of the cell or are secreted. Among those proteins there may be new targets for vaccine and antibiotic development.
authors.affiliation: Infectious Diseases Research and Clinical Investigation, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hoskins
authors.forename: W E
authors.initials: WE
authors.lastname: Alborn
authors.forename: J
authors.initials: J
authors.lastname: Arnold
authors.forename: L C
authors.initials: LC
authors.lastname: Blaszczak
authors.forename: S
authors.initials: S
authors.lastname: Burgett
authors.forename: B S
authors.initials: BS
authors.lastname: DeHoff
authors.forename: S T
authors.initials: ST
authors.lastname: Estrem
authors.forename: L
authors.initials: L
authors.lastname: Fritz
authors.forename: D J
authors.initials: DJ
authors.lastname: Fu
authors.forename: W
authors.initials: W
authors.lastname: Fuller
authors.forename: C
authors.initials: C
authors.lastname: Geringer
authors.forename: R
authors.initials: R
authors.lastname: Gilmour
authors.forename: J S
authors.initials: JS
authors.lastname: Glass
authors.forename: H
authors.initials: H
authors.lastname: Khoja
authors.forename: A R
authors.initials: AR
authors.lastname: Kraft
authors.forename: R E
authors.initials: RE
authors.lastname: Lagace
authors.forename: D J
authors.initials: DJ
authors.lastname: LeBlanc
authors.forename: L N
authors.initials: LN
authors.lastname: Lee
authors.forename: E J
authors.initials: EJ
authors.lastname: Lefkowitz
authors.forename: J
authors.initials: J
authors.lastname: Lu
authors.forename: P
authors.initials: P
authors.lastname: Matsushima
authors.forename: S M
authors.initials: SM
authors.lastname: McAhren
authors.forename: M
authors.initials: M
authors.lastname: McHenney
authors.forename: K
authors.initials: K
authors.lastname: McLeaster
authors.forename: C W
authors.initials: CW
authors.lastname: Mundy
authors.forename: T I
authors.initials: TI
authors.lastname: Nicas
authors.forename: F H
authors.initials: FH
authors.lastname: Norris
authors.forename: M
authors.initials: M
authors.lastname: O'Gara
authors.forename: R B
authors.initials: RB
authors.lastname: Peery
authors.forename: G T
authors.initials: GT
authors.lastname: Robertson
authors.forename: P
authors.initials: P
authors.lastname: Rockey
authors.forename: P M
authors.initials: PM
authors.lastname: Sun
authors.forename: M E
authors.initials: ME
authors.lastname: Winkler
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Young-Bellido
authors.forename: G
authors.initials: G
authors.lastname: Zhao
authors.forename: C A
authors.initials: CA
authors.lastname: Zook
authors.forename: R H
authors.initials: RH
authors.lastname: Baltz
authors.forename: S R
authors.initials: SR
authors.lastname: Jaskunas
authors.forename: P R
authors.initials: PR
authors.lastname: Rosteck
authors.forename: P L
authors.initials: PL
authors.lastname: Skatrud
authors.forename: J I
authors.initials: JI
authors.lastname: Glass
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004251:DNA Transposable Elements / Q000235:genetics; D016680:Genome, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013296:Streptococcus pneumoniae / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004251:DNA Transposable Elements