title: Liver transplantation for alcoholic cirrhosis: long term follow-up and impact of disease recurrence.
abstract: BACKGROUND
  Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is a controversial use of resources. We aimed to examine all aspects of liver transplantation associated with alcohol abuse.
  
  
  METHODS
  Retrospective cohort analysis of 123 alcoholic patients with a median of 7 years follow-up at one center.
  
  
  RESULTS
  In addition to alcohol, 43 (35%) patients had another possible factor contributing to cirrhosis. Actuarial patient and graft survival rates were, respectively, 84% and 81% (1 year); 72% and 66% (5 years); and 63% and 59% (7 years). After transplantation, 18 patients (15%) manifested 21 noncutaneous de novo malignancies, which is significantly more than controls (P=0.0001); upper aerodigestive squamous carcinomas were overrepresented (P=0.03). Thirteen patients had definitely relapsed and three others were suspected to have relapsed. Relapse was predicted by daily ethanol consumption (P=0.0314), but not by duration of pretransplant sobriety or explant histology. No patient had alcoholic hepatitis after transplantation and neither late onset acute nor chronic rejection was significantly increased. Multiple regression analyses for predictors of graft failure identified major biliary/vascular complications (P=0.01), chronic bile duct injury on biopsy (P=0.002), and pericellular fibrosis on biopsy (P=0.05); graft viral hepatitis was marginally significant (P=0.07) on univariate analysis.
  
  
  CONCLUSIONS
  Alcoholic liver disease is an excellent indication for liver transplantation in those without coexistent conditions. Recurrent alcoholic liver disease alone is not an important cause of graft pathology or failure. Potential recipients should be heavily screened before transplantation for coexistent conditions (e.g., hepatitis C, metabolic diseases) and other target-organ damage, especially aerodigestive malignancy, which are greater causes of morbidity and mortality than is recurrent alcohol liver disease.
authors.affiliation: Department of Pathology, Edinburgh University Medical School, Scotland.
authors.forename: C O
authors.initials: CO
authors.lastname: Bellamy
authors.forename: A M
authors.initials: AM
authors.lastname: DiMartini
authors.forename: K
authors.initials: K
authors.lastname: Ruppert
authors.forename: A
authors.initials: A
authors.lastname: Jain
authors.forename: F
authors.initials: F
authors.lastname: Dodson
authors.forename: M
authors.initials: M
authors.lastname: Torbenson
authors.forename: T E
authors.initials: TE
authors.lastname: Starzl
authors.forename: J J
authors.initials: JJ
authors.lastname: Fung
authors.forename: A J
authors.initials: AJ
authors.lastname: Demetris
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D008099:Liver / Q000473:pathology / Q000503:physiopathology; D008104:Liver Cirrhosis, Alcoholic / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D011183:Postoperative Complications; D011184:Postoperative Period; D012008:Recurrence; D012189:Retrospective Studies; D016019:Survival Analysis