Individual sensitivity to genotoxic effects of nickel and antimutagenic activity of ascorbic acid.
Cytotoxicity of nickel compounds was studied by stimulating the repair synthesis of DNA and counting lymphocyte micronuclei in workers of smelting shop of copper-nickel sulfide processing plant. Nickel content in the organism was evaluated by its concentrations in hair. Therapy with ascorbic acid (1 g/day for 1 month) led to a significant decrease in the number of micronuclei. The number of micronuclei before and after ascorbic acid treatment varied within a wide range in different individuals.
Perminova
I N
IN
Group of Medical Ecological Studies, Institute of Industrial Ecology Problems of the North, Karelian Research Center, Russian Academy of Sciences, Apatity.
Sinel'shchikova
T A
TA
Alekhina
N I
NI
Perminova
E V
EV
Zasukhina
G D
GD
D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000378:metabolism; D000396:Air Pollutants, Radioactive / Q000009:adverse effects* / Q000378:metabolism; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004249:DNA Damage; D006197:Hair / Q000378:metabolism; D006801:Humans; D048629:Micronuclei, Chromosome-Defective; D009153:Mutagens / Q000009:adverse effects* / Q000378:metabolism; D009532:Nickel / Q000009:adverse effects* / Q000378:metabolism
D000395:Air Pollutants, Occupational; D000396:Air Pollutants, Radioactive; D016587:Antimutagenic Agents; D009153:Mutagens; D009532:Nickel; D001205:Ascorbic Acid