title: Identification and quantitation of 11-nor-delta9-tetrahydrocannabivarin-9-carboxylic acid, a major metabolite of delta9-tetrahydrocannabivarin.
abstract: After incubation of delta9-tetrahydrocannabivarin with human hepatocytes, a major metabolic product was detected by gas chromatography-mass spectrometry that showed identical retention time and mass spectrum to the synthetic 11-nor-delta9-tetrahydrocannabivarin-9-carboxylic acid (11-nor-delta9-THCV-9-COOH). Analysis of human urine specimens from marijuana users and plasma samples from Marinol users showed that 11-nor-delta9-THCV-9-COOH was only present in urine specimens of marijuana users. These results supported the conclusion that identification of 11-nor-delta9-THCV-9-COOH in a donor's urine specimen indicates the use or ingestion of cannabis-related product(s) and would not explain the sole use of Marinol.
authors.affiliation: ElSohly Laboratories, Incorporated, Oxford, Mississippi 38655, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: ElSohly
authors.forename: S
authors.initials: S
authors.lastname: Feng
authors.forename: T P
authors.initials: TP
authors.lastname: Murphy
authors.forename: A W
authors.initials: AW
authors.lastname: Warrington
authors.forename: S
authors.initials: S
authors.lastname: Ross
authors.forename: A
authors.initials: A
authors.lastname: Nimrod
authors.forename: Z
authors.initials: Z
authors.lastname: Mehmedic
authors.forename: N
authors.initials: N
authors.lastname: Fortner
mesh_terms: D002851:Chromatography, High Pressure Liquid; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000032:analysis* / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry; D006213:Hallucinogens / Q000652:urine*; D006801:Humans; D002189:Marijuana Abuse / Q000175:diagnosis*; D016482:Urinalysis
chemical_list: D006213:Hallucinogens; C003403:tetrahydrocannabivarin 9; D013759:Dronabinol