Histoprotective effect of antihypoxant olifen during experimental acute pancreatitis.
We evaluated the efficiency of perfusion with olifen in preventing oxidative stress at the early stage of acute pancreatitis. Transaortic perfusion with olifen prevented clinical and biochemical symptoms of acute pancreatitis, attenuated oxidative stress, reduced peritoneal exudation, and restricts the area of pancreatic necrosis to 6% tissue.
Tolstoi
A D
AD
I. I. Dzhanelidze St. Petersburg Institute of Ambulance Service.
Dzhurko
B I
BI
Vashetko
R V
RV
Medvedev
Y V
YV
Gol'tsov
V R
VR
Dvoinov
V G
VG
Zakharova
E V
EV
D000681:Amylases / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002415:Cats; D004195:Disease Models, Animal; D019344:Lactic Acid / Q000097:blood; D018384:Oxidative Stress; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D010647:Phenyl Ethers / Q000494:pharmacology*
D000975:Antioxidants; D010647:Phenyl Ethers; C085806:olifen; D019344:Lactic Acid; D000681:Amylases