Experiment on aggregation of red cells under microgravity on STS 51-C.
Kinetics and morphology of aggregation of red cells were studied using automatic slit-capillary photo-viscometers, one situated on the middeck of the space shuttle 'Discovery', and the other in the ground laboratory at KSC.  Experiments were run simultaneously, blood samples being adjusted to haematocrit of 0.30 using native plasma, at temp. of 25 degrees C, and anticoagulated by EDTA.  Donors included patients with myocardial infarction, insulin-dependent diabetes, hyperlipidaemia and hypertension.  Macro and microphotographs were obtained during flow and stasis.  There was a striking difference in the morphology of aggregates formed in space and on the ground.  Aggregates formed under zero gravity showed rouleaux formation, while the same blood samples showed severe clumping on the ground, in all patients blood.  Normal blood showed rouleaux on the ground, but a random swarm-like pattern in space.  The shape of the red cells remained normal under zero gravity.
Dintenfass
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L
Department of Medicine, University of Sydney, Australia.
Osman
P
P
Maguire
B
B
Jedrzejczyk
H
H
D003110:Colonic Neoplasms / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D004903:Erythrocyte Aggregation / Q000502:physiology*; D004912:Erythrocytes / Q000166:cytology; D018056:Hemorheology; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D006973:Hypertension / Q000097:blood; D066298:In Vitro Techniques; D009203:Myocardial Infarction / Q000097:blood; D012397:Rosette Formation; D013026:Space Flight / Q000295:instrumentation*; D014893:Weightlessness