title: Toxic shock-like syndrome with flu-like prodrome: a possible role of 'enhancing tissue focus' for streptococcal toxic shock.
abstract: We describe three patients with invasive group A streptococcal infection, admitted during the 3 months between November 1996 and February 1997. All patients were previously healthy Japanese women who developed a profound shock, with a rapidly fatal outcome, after experiencing flu-like symptoms. All cases conformed to the case definition of toxic shock-like syndrome (TSLS).Currently, the pathogenic mechanism of TSLS remains unclear. Known microbial virulence factors can not sufficiently explain the occurrence of TSLS, and it has been generally considered that host factors may be contributory. On pathological examination, each patient had one organ or tissue that was most severely involved: Case 1 a non-penetrating trauma; Case 2 a pregnant uterus; and Case 3 a pulmonary lesion reminiscent of lymphocytic interstitial pneumonia. On the basis of clinicopathological features of these cases, we propose that the coexistence of 'enhancing tissue focus' may be one of host factors for the progression of TSLS in patients infected with non-invasive GAS.
authors.affiliation: Emergency and Critical Care Medical Center, Niigata City General Hospital, Niigata City, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hirose
authors.forename: H
authors.initials: H
authors.lastname: Shibuya
authors.forename: E
authors.initials: E
authors.lastname: Okazaki
authors.forename: K
authors.initials: K
authors.lastname: Aono
authors.forename: A
authors.initials: A
authors.lastname: Tokunaga
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: M
authors.initials: M
authors.lastname: Haraguchi
authors.forename: H
authors.initials: H
authors.lastname: Honda
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007869:Leg Injuries / Q000150:complications*; D010612:Pharyngitis / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000175:diagnosis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000382:microbiology; D011263:Pregnancy Trimester, Third; D012772:Shock, Septic / Q000175:diagnosis* / Q000382:microbiology*; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000302:isolation & purification; D014949:Wounds, Nonpenetrating / Q000150:complications*