title: Heavy ion-induced chromosomal damage and repair.
abstract: We have been using the "premature chromosome condensation (PCC)" technique to investigate chromosomal breakage, rejoining and misrepair induced by accelerated heavy ions.  With the presentation of new Fe experiments, we now review the available PCC data to summarize our current understanding of the action of high velocity charged particles on mammalian chromosomes.  Implications for the survival RBE/LET relationship are also discussed.
authors.affiliation: Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720, USA.
authors.forename: E H
authors.initials: EH
authors.lastname: Goodwin
authors.forename: E A
authors.initials: EA
authors.lastname: Blakely
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D002843:Chromatin / Q000528:radiation effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D006822:Hybrid Cells / Q000528:radiation effects; D007477:Ions; D007501:Iron; D018499:Linear Energy Transfer; D011839:Radiation, Ionizing; D011853:Radiobiology / Q000379:methods* / Q000706:statistics & numerical data; D012062:Relative Biological Effectiveness
chemical_list: D002843:Chromatin; D007477:Ions; D004247:DNA; D007501:Iron