Fish scale development: Hair today, teeth and scales yesterday?
A group of genes in the tumour necrosis factor signalling pathway are mutated in humans and mice with ectodermal dysplasias--a failure of hair and tooth development. A mutation has now been identified in one of these genes, ectodysplasin-A receptor, in the teleost fish Medaka, that results in a failure of scale formation.
Sharpe
P T
PT
Department of Craniofacial Development, Floor 28 Guy's Tower, Guy's Hospital, London SE1 9RT, UK.
D000818:Animals; D005075:Biological Evolution; D053331:Ectodysplasins; D053339:Edar Receptor; D029941:Fish Proteins / Q000235:genetics / Q000502:physiology*; D006197:Hair; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D009990:Oryzias; D014070:Tooth; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
C506018:EDA protein, human; D053331:Ectodysplasins; C506019:Eda protein, mouse; D053339:Edar Receptor; D029941:Fish Proteins; D008565:Membrane Proteins; D014409:Tumor Necrosis Factor-alpha; C438683:ectodysplasin-A receptor protein, Oryzias latipes