[Experimental evaluation of efficacy of Lactobacilli in prophylaxis and treatment of cholera].
Investigations on experimental models of cholera ("sealed" mice and suckling rabbits) demonstrated that previous daily oral administration of the ferment culture of Lactobacillus acidophilus BKM B-2020[symbol: see text] in a dose of 3.0 x 10(8) microbial cells/ml daily for 5-7 days prevented to the development of Vibrio cholerae infection. The curative effect observed after 3 administrations of lactobacilli within 48 hours after infection with V. cholerae was registered in 50% of cases. This strain of lactobacilli was found to be suitable for use as the basis component of probiotic, an additional remedy for the prophylaxis and treatment of cholera.
Bardykh
I D
ID
Research Institute for Plague Control, Rostov-on-Don, Russia.
Krylikov
V D
VD
Mazrukho
B L
BL
Ryzhko
I V
IV
Moskvitina
E A
EA
Tsuraeva
R I
RI
Vinokur
N I
NI
Drobotkovskaia
N V
NV
D000818:Animals; D000833:Animals, Suckling; D002771:Cholera / Q000517:prevention & control / Q000628:therapy*; D007779:Lactobacillus acidophilus; D051379:Mice; D019936:Probiotics / Q000627:therapeutic use*; D011817:Rabbits