Synthetic peptide thymodepressin promoted take of transplanted hemopoietic precursor cells in the bone marrow of irradiated mice.
We studied the possibility of using a new synthetic heme-inhibiting peptide thymodepressin for improving the efficiency of transplantations of syngeneic and allogeneic bone marrow. Thymodepressin was injected to recipients 3 times (48, 24, and 2 h) before irradiation and transplantation of bone marrow suspension. The yield of 9- and 12-day colonies increased, the number of proliferating CFU-S-12 and pre-CFU-S in recipient bone marrow increased in comparison with the control. In case of an allogeneic donor-recipient combination, the number of 9-day splenic colonies in thymodepressin-treated animals increased 5-fold compared to the control. We hypothesized that thymodepressin therapy and irradiation form an adaptive response of the recipient hemopoietic microenvironment in the bone marrow, which provides conditions for optimal functioning of donor hemopoietic precursors.
Semina
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OV
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. mrrc@obninsk.ru
Semenets
T N
TN
Poverennyi
A M
AM
Deigin
V I
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D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D013997:Time Factors
D007166:Immunosuppressive Agents; D010455:Peptides; C449663:thymodepressin