Discerning ionic currents and their kinetics from input impedance data.
The excitable nature of a biological cell is manifested in the many voltage gated ion channels that perforate its membrane. The forms of the associated ionic currents, and in particular the functions that govern their kinetics, permit one to distinguish, electrophysiologically, between various cell types. We show, in the context of FitzHugh-Nagumo and Morris-Lecar models and without recourse to voltage or space clamping, that such currents and kinetics may be stably inferred from a cell's voltage response to a specified input current.
Cox
S J
SJ
Department of Computational and Applied Mathematics, Rice University, 6100 Main St., Houston, TX 77005, USA. cox@rice.edu
Ji
L
L
D000465:Algorithms; D015220:Calcium Channels / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D017097:Electric Impedance; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008954:Models, Biological; D015221:Potassium Channels / Q000502:physiology
D015220:Calcium Channels; D007473:Ion Channels; D015221:Potassium Channels