title: Effect of +Gz on plasma levels of calcitonin gene related peptide, endothelin and renal function in pilots.
abstract: The effect of positive acceleration on plasma levels of calcitonin gene related peptide (CGRP), and endothelin as well as renal function in pilots were observed in this study. 20 pilots were exposed to +2.5 Gz 10 s and +3.0 Gz 10 s with an interval of 5 min without anti-G suits. Samples of plasma and serum were taken 2Omin before and after exposure. Plasma levels of CGRP and endothelin after the exposure were significantly increased (P<0.01), but alkaline phosphatase(AKP), blood levels of beta 2-microglobulin(beta 2-MG), Ca2+ in serum showed no significant change (P>0.05) as compared with those before exposure. There was a correlation between CGRP and endothlin (r=0.772, P<0.01). It is concluded that positive acceleration(+2.5, +3.0Gz) could increase plasma levels of CGRP and endothlin but did not affect renal function.
authors.affiliation: Department of Nuclear Medicine, General Hospital of Air Force, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Dai
authors.forename: G
authors.initials: G
authors.lastname: Ji
authors.forename: D
authors.initials: D
authors.lastname: Dai
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Xiao
mesh_terms: D000054:Acceleration; D000328:Adult; D000337:Aerospace Medicine; D000469:Alkaline Phosphatase / Q000097:blood; D001806:Blood Urea Nitrogen; D015740:Calcitonin Gene-Related Peptide / Q000097:blood / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002681:China; D003401:Creatine / Q000097:blood; D019332:Endothelin-1 / Q000097:blood / Q000378:metabolism*; D006801:Humans; D018471:Hypergravity; D007668:Kidney / Q000502:physiology*; D008297:Male; D008889:Military Personnel; D001613:beta 2-Microglobulin / Q000378:metabolism
chemical_list: D019332:Endothelin-1; D001613:beta 2-Microglobulin; D000469:Alkaline Phosphatase; D015740:Calcitonin Gene-Related Peptide; D003401:Creatine; D002118:Calcium