title: Effects of mosapride citrate on human plasma levels of motilin, gastrin, somatostatin, and secretin.
abstract: The effect of mosapride citrate (mosapride) on plasma levels of gastrointestinal peptides (motilin, gastrin, somatostatin, and secretin) was studied in five healthy volunteers. After a single oral administration of mosapride (15 mg), the plasma mosapride level (85.0+/-13.7 ng/ml) was highest in the 60-min sample after the administration and then the plasma level fell. Peak plasma motilin levels (18.6+/-1.7 pg/ml) were achieved 60 min after administration of mosapride (p<0.01 vs. placebo), and returned to baseline levels within a further 120 min. Plasma gastrin levels (42.4+/-3.6 pg/ml) increased 60 min after administration of mosapride (p<0.01 vs. placebo). Plasma somatostatin and secretin levels did not change significantly. These results suggest that the pharmacological effects of mosapride on gastrointestinal functions are closely related to changes in motilin-immunoreactive substance levels in human plasma.
authors.affiliation: Department of Clinical Pharmacy, Oita Medical University, Japan. itoh@oita-med.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Nagano
authors.forename: M
authors.initials: M
authors.lastname: Takeyama
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001549:Benzamides / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D005755:Gastrins / Q000097:blood*; D005765:Gastrointestinal Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009025:Morpholines / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D009037:Motilin / Q000097:blood*; D012633:Secretin / Q000097:blood*; D013004:Somatostatin / Q000097:blood*
chemical_list: D001549:Benzamides; D005755:Gastrins; D005765:Gastrointestinal Agents; D009025:Morpholines; D012633:Secretin; D013004:Somatostatin; D009037:Motilin; C062720:mosapride