[Myocardial injury caused by reperfusion].
Arterial coronary occlusion produces ischaemic changes, and alter the aerobic metabolism, creatinephosphate depletion and accumulation of anoxic metabolites in the ischaemic tissue, with an alteration in the calcium regulation. With the recovery of the blood flow, the myocardial ischaemic injury and infarct zone are diminished, leading to an improvement of survival. The adverse effect induced by the reperfusion of ischaemic cells with the production of free radicals and dearrangements in the glucose metabolism, fatty acids and intracellular calcium flow as well, has been proven. There are 4 kinds of reperfusion damage: stunned myocardium, reperfusion arrhythmia, no-reflow phenomena, and cellular death, all of them with a particular physiopathology. Nowadays, there are too many paraclinics in order to reach a diagnosis, and perhaps the only available treatment is still under research. This field has great expectancy in the future. In this article, some of the contemporary concepts are reviewed.
Férez
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Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, 14080 México, D.F.
Ocaranza Sánchez
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Márquez
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D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology