title: An overview of the role and inter-relationship of epidermal growth factor receptor, cyclin D and retinoblastoma protein on the carcinogenesis of squamous cell carcinoma of the larynx.
abstract: Recent developments in both molecular and cellular biology have improved the understanding of the tumorigenesis of laryngeal squamous cell carcinoma. Loco-regional recurrence of this condition still poses a significant oncological management dilemma for a subset of these tumours. Therefore, the possibility that specific tumour characteristics (demonstrable by immunohistochemical and molecular biological study) may aid the clinician in choosing the optimal treatment for a specific tumour holds great promise. This article concentrates on the role and inter-relationship of epidermal growth factor receptor status on the function of cyclin D, and how this is related to the presence of retinoblastoma protein. A review of recent studies evaluating these markers, the potential clinical utility of these findings and the possible directions for further study are discussed.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, University of Liverpool, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Rafferty
authors.forename: J E
authors.initials: JE
authors.lastname: Fenton
authors.forename: A S
authors.initials: AS
authors.lastname: Jones
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology; D003043:Cocarcinogenesis; D056741:Cyclin D; D016213:Cyclins / Q000235:genetics / Q000378:metabolism*; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D056741:Cyclin D; D016213:Cyclins; D016160:Retinoblastoma Protein; D066246:ErbB Receptors