title: Effect of total body irradiation on peri-implant tissue reaction: an experimental study.
abstract: The aim of the present study was to evaluate the osseointegration process under total body irradiation conditions (LD 50/30). Twenty Wistar rats (mean body weight: 90 g) were used. Under ethyl urethane intraperitoneal anesthesia (1 g/kg body weight), the animals were irradiated with a single 700 cGy dose (linear accelerator 6 Mev photons). Four days post irradiation, a titanium laminar implant was placed in the left tibia of each rat. Antibiotic therapy (ceftriaxone) was administered daily post implantation, to prevent infection by radiation. Fourteen days post implantation, the animals were killed by ether overdose. The tibiae were resected, radiographed and processed for embedding in methyl methacrylate. The results showed impaired osteogenesis and absence of osseointegration in experimental tibiae. This could be due to a direct action of total body irradiation on osteogenesis precursor cells. This effect would impair bone formation involved in peri-implant osseointegration processes in this experimental model.
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, University of Buenos Aires, Marcelo T. de Alvear 2142, 2oA [1122], Capital Federal, Argentina.
authors.forename: S J
authors.initials: SJ
authors.lastname: Renou
authors.forename: M B
authors.initials: MB
authors.lastname: Guglielmotti
authors.forename: A
authors.initials: A
authors.lastname: de la Torre
authors.forename: R L
authors.initials: RL
authors.lastname: Cabrini
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001842:Bone and Bones / Q000528:radiation effects*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005500:Follow-Up Studies; D008297:Male; D008859:Microscopy, Polarization; D023421:Models, Animal; D016348:Osseointegration; D010012:Osteogenesis / Q000528:radiation effects; D016613:Plastic Embedding; D011829:Radiation Dosage; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D013223:Statistics as Topic; D013234:Stem Cells / Q000528:radiation effects; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D014025:Titanium; D014916:Whole-Body Irradiation
chemical_list: D015921:Dental Implants; D014025:Titanium