[Effect of synthetic muramyl dipeptide derivatives on staphylococcal infection in mice].
The work deals with the results of experimental evaluation of the influence of some new modified derivatives of muramyldipeptide (MDP) on the course of staphylococcal infection in mice. The preparations under study were found to produce rapid elimination of bacteria from kidneys and the increase of phagocytic activity of blood macrophages in animals. At the same time MDP and its derivatives stimulated natural killer cells whose activity was inhibited during infection. The dependence between the structure of these compounds and their protective action in staphylococcal infection, as well as the increase of the natural immunity characteristics of the body was followed.
Grabchenko
N I
NI
Zabolotny Institute of Microbiology and Virology, Kiev, Ukraine.
Karpov
A V
AV
Chirva
V Ia
VIa
Tkachikova
L
L
Spivak
N Ia
NIa
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D006020:Glycopeptides / Q000627:therapeutic use*; D006027:Glycosides / Q000627:therapeutic use*; D051379:Mice; D008808:Mice, Inbred CBA; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000276:immunology
D000276:Adjuvants, Immunologic; D006020:Glycopeptides; D006027:Glycosides; C403942:heptylglycoside-muramyldipeptide; D000119:Acetylmuramyl-Alanyl-Isoglutamine