title: [Changes in oxygenation indexes with the use of nitric oxide in the postoperative period of congenital heart disease surgery in patients with severe pulmonary hypertension].
abstract: In this clinical study, 7 pediatric patients with severe pulmonary artery hypertension, secondary to congenital heart disease, received inhaled nitric oxide at doses of 20 ppm in the acute postoperative management of congenital heart repair for 3.5 days. Monitoring included oxygenation index, alveoloarterial oxygen difference, pulmonary and systemic pressure, measurements were recorded previous to the NO administration; 1, 6, 12, 24, 36, 48 and 72 hours after treatment with NO, nitrous oxide (NO2) and seric methemoglobin also were monitored.
  
  
  RESULTS
  Average age was 3.6 years. The oxygenation index before inhaling NO was 166 +/- 100, 72 hours following inhalation of NO the oxygenation index was 210 +/- 98. The alveolo-arterial baseline oxygen difference was 270 +/- 145; 72 hours after inhaling NO, it was 163 +/- 167. No decreases in pulmonary and systemic arterial pressure during NO inhalation occured. The levels of NO2 and seric methemoglobin were not toxic.
  
  
  CONCLUSIONS
  Treatment with inhaled NO after cardiac surgery in children with severe pulmonary artery hypertension secondary to congenital heart disease may be useful to improve oxygenation with no changes in pulmonary and systemic arterial pressure. Inhaled NO at 20 ppm did not cause toxicity.
authors.affiliation: Unidad de Cuidados Intensivos Postquirúrgicos del Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, 14080 México, D.F.
authors.forename: L
authors.initials: L
authors.lastname: Ramírez Ramírez
authors.forename: J
authors.initials: J
authors.lastname: Calderón Colmenero
authors.forename: E
authors.initials: E
authors.lastname: Zarco Martínez
authors.forename: J A
authors.initials: JA
authors.lastname: García Montes
authors.forename: J
authors.initials: J
authors.lastname: Molina Méndez
authors.forename: G
authors.initials: G
authors.lastname: Fernández de la Reguera
mesh_terms: D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications* / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000378:metabolism; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009569:Nitric Oxide / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D011184:Postoperative Period; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D009569:Nitric Oxide