Effects of mosapride citrate on human plasma levels of motilin, gastrin, somatostatin, and secretin.
The effect of mosapride citrate (mosapride) on plasma levels of gastrointestinal peptides (motilin, gastrin, somatostatin, and secretin) was studied in five healthy volunteers. After a single oral administration of mosapride (15 mg), the plasma mosapride level (85.0+/-13.7 ng/ml) was highest in the 60-min sample after the administration and then the plasma level fell. Peak plasma motilin levels (18.6+/-1.7 pg/ml) were achieved 60 min after administration of mosapride (p<0.01 vs. placebo), and returned to baseline levels within a further 120 min. Plasma gastrin levels (42.4+/-3.6 pg/ml) increased 60 min after administration of mosapride (p<0.01 vs. placebo). Plasma somatostatin and secretin levels did not change significantly. These results suggest that the pharmacological effects of mosapride on gastrointestinal functions are closely related to changes in motilin-immunoreactive substance levels in human plasma.
Itoh
H
H
Department of Clinical Pharmacy, Oita Medical University, Japan. itoh@oita-med.ac.jp
Nagano
T
T
Takeyama
M
M
D000328:Adult; D019540:Area Under Curve; D001549:Benzamides / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D005755:Gastrins / Q000097:blood*; D005765:Gastrointestinal Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009025:Morpholines / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D009037:Motilin / Q000097:blood*; D012633:Secretin / Q000097:blood*; D013004:Somatostatin / Q000097:blood*
D001549:Benzamides; D005755:Gastrins; D005765:Gastrointestinal Agents; D009025:Morpholines; D012633:Secretin; D013004:Somatostatin; D009037:Motilin; C062720:mosapride