[Immunoprophylaxis of acute respiratory diseases with bacterial multicomponent vaccine VP-4 in children at preschool institutions].
The prophylactic action of polycomponent vaccine B[symbol: see text]-4, prepared from the antigens of opportunistic bacteria, on morbidity rate in acute respiratory diseases (ARD) of bacterial and mixed (bacterial and viral) etiology in 121 children aged 2-5 years, attending pre-school institutions was evaluated. For comparison, a group of 118 children of the same age from the same institutions was formed. The vaccine was introduced after the schedule consisting of 3 intranasal and 6-9 oral administrations made at intervals of 3-4 days. The duration of the course of immunization was 26 +/- 4 days. The prophylactic effect of B[symbol: see text]-4 on ARD morbidity was evaluated by the number of ARD cases and their duration per child. The prophylactic effect of B[symbol: see text]-4 on ARD morbidity lasted 14 months (the term of observation) after immunization and was manifested by a decrease in the number and duration of ARD cases after administration of the preparation, also in a group of highly susceptible children.
Egorova
N B
NB
Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
Semenov
B F
BF
Kurbatova
E A
EA
Efremova
V N
VN
Gruber
I M
IM
Kuz'mina
L A
LA
Semenova
I B
IB
Lytkina
I N
IN
Serzhenko
S V
SV
Samarina
O P
OP
Slepoĭ
Iu D
IuD
Egorova
N V
NV
D000208:Acute Disease; D001428:Bacterial Vaccines; D002648:Child; D002675:Child, Preschool; D006801:Humans; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control* / Q000821:virology; D017778:Vaccines, Combined
D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined