Antidepressant activity of aspartic acid derivatives.
Antidepressant activity of N-phenyl(benzyl)amino derivatives of aspartic acid was studied on various experimental models of depression. IEM-1770 (30 mg/kg) and IEM-1944 (20 mg/kg) exhibited antidepressant activity after single injection in the forced swimming and tail suspension tests. Antidepressant effect of 14-day administration of these compounds and reference drugs maprotiline (10 mg/kg) and citalopram (10 mg/kg) was confirmed on the model of learned helplessness.
Petrov
V I
VI
Laboratory of Psychopharmacology, Institute of Pharmacology, Volgograd Medical Academy, St.-Petersburg.
Sergeev
V S
VS
Onishchenko
N V
NV
Piotrovskii
L B
LB
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013550:Swimming
D000928:Antidepressive Agents; C445421:IEM1770; C445422:IEM1944; D001224:Aspartic Acid