title: Relapsing intracranial Rosai-Dorfman disease.
abstract: Two patients presenting with recurrent visual impairment due to relapsing intracranial Rosai-Dorfman disease are described. In both patients a preoperative diagnosis of meningioma was made. Histological examination disclosed the characteristic picture of S100 and CD68 positive histiocytosis with prominent lymphophagocytosis. In both patients complete tumour removal by surgery was impossible with residual tissue being the origin of relapsing disease. Low dose radiation led to partial recovery of vision and resolution of the intracranial mass. Review of the literature on intracranial Rosai-Dorfman disease leads to the suggestion that postoperative radiotherapy may be advisable in all cases.
authors.affiliation: Department of Neuroimmunology, Institute of Neurology, Queen Square, London WC1N 3BG and Moorfields Eye Hospital, City Road, London EC1 2PD, UK. a.petzold@ion.ucl.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Petzold
authors.forename: M
authors.initials: M
authors.lastname: Thom
authors.forename: M
authors.initials: M
authors.lastname: Powell
authors.forename: G T
authors.initials: GT
authors.lastname: Plant
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003399:Craniotomy; D003937:Diagnosis, Differential; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D009418:S100 Proteins / Q000032:analysis; D013493:Suprachiasmatic Nucleus / Q000473:pathology; D015354:Vision, Low / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule