A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse.
Despite the potential importance of the mouse in studying the pharmacology of aqueous dynamics, measurement of intraocular pressure (IOP) in its very small eye has been problematic. Utilizing a novel servo-null electrophysiologic approach recently applied to the mouse, we have identified a diversity of adenosine-receptor mechanisms in modulating IOP in this species. We report the first evidence that A(3) receptors increase IOP in any species, and verify in the mouse reports with larger mammals that A(1) receptors lower and A(2A) receptors increase IOP.
Avila
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MY
Department of Physiology, A303 Richards Building, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6085, USA.
Stone
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RA
Civan
M M
MM
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D004095:Dihydropyridines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D043705:Receptor, Adenosine A2A; D043684:Receptor, Adenosine A3; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D013997:Time Factors
D004095:Dihydropyridines; C107728:MRS 1191; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D043705:Receptor, Adenosine A2A; D043684:Receptor, Adenosine A3; D018047:Receptors, Purinergic P1; D000241:Adenosine