[Transforming growth factor alpha (TGF-alpha) and epidermoid growth factor (EGF) in polycystic ovary syndrome: potential role in the decrease of apoptosis mechanisms in the follicle].
Knowledgement on ovary function regulation is advancing. Classic concept about endocrine regulation by sexual hormones and gonadotrophin has turning to an hypothesis: autocrine and paracrine factors as intra-ovarian regulators. Follicular growth and steroidogenesis are mainly driven by follicle stimulating hormone (FSH), luteine hormone (LH) and steroids. On the other hand, the presence of intra-ovarian growth factors have an important role in modulation of gonadotrophin effects on ovarian functions. The influence of this factors on follicle growth are described.
Morales González
J A
JA
Facultad de Odontología, UNAM.
Gutiérrez Salinas
J
J
Paz Avila
J
J
Sauceda González
L F
LF
Montes Balderas
J L
JL
D017209:Apoptosis / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D016211:Transforming Growth Factor alpha / Q000627:therapeutic use*
D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor