title: The peopling of the Canary Islands: a CD4/Alu microsatellite haplotype perspective.
abstract: A new CD4 microsatellite allele with three TTTTC complete repetitions, previously described only in hominoids, has been found in this screening. The number of haplotypes and heterozygosities in the Canary Islands (15 and 0.746+/-0.007) is more similar to Iberian (14 and 0.748+/-0.015) than to North African (18 and 0.827+/-0.009) values. However, in some islands, with less European migratory impact, haplotypes with major African assignation (90[+] and 130[+]) reach frequencies similar to African populations. There is a significant negative correlation between geographic distances to Africa and insular heterozygosity values, which suggests a main aborigine colonization from East to West still detectable today.
authors.affiliation: Departamento de Genética, Universidad de La Laguna, E-38271, Islas Canarias, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Flores
authors.forename: N
authors.initials: N
authors.lastname: Maca-Meyer
authors.forename: J A
authors.initials: JA
authors.lastname: Peŕez
authors.forename: V M
authors.initials: VM
authors.lastname: Cabrera
mesh_terms: D000483:Alleles; D020087:Alu Elements / Q000235:genetics*; D001266:Atlantic Islands; D015704:CD4 Antigens / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D018895:Microsatellite Repeats / Q000235:genetics*; D020080:Tandem Repeat Sequences / Q000235:genetics
chemical_list: D015704:CD4 Antigens; D005819:Genetic Markers