title: Preparation and studies with 90Y-labelled particles for use in radiation synovectomy.
abstract: 90Y-FHMA (Ferric hydroxide macroaggregates) and 90Y-HA (hydroxyapatite) were prepared in >95% yield using 90Y from an in-house 90Sr-90Y generator. Most of the particles ranged from 5 to 20 microm in diameter and retained radiochemical purity > 95% in human serum for at least 7 days at 37 degrees C. Gamma camera imaging of normal rabbits after intraarticulation of the particles showed complete retention of activity within the knee cavity with no measurable radioactivity leaching out of the joints over a 96 hour period.
authors.affiliation: Radiopharmaceutical Division, Bhabha Atomic Research Centre, Mumbai, India.
authors.forename: U
authors.initials: U
authors.lastname: Pandey
authors.forename: A
authors.initials: A
authors.lastname: Mukherjee
authors.forename: P R
authors.initials: PR
authors.lastname: Chaudhary
authors.forename: M R
authors.initials: MR
authors.lastname: Pillai
authors.forename: M
authors.initials: M
authors.lastname: Venkates
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000532:radiotherapy; D004355:Drug Stability; D017886:Durapatite; D005290:Ferric Compounds; D006801:Humans; D066298:In Vitro Techniques; D010316:Particle Size; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000302:isolation & purification / Q000627:therapeutic use; D013583:Synovial Membrane / Q000528:radiation effects*; D015021:Yttrium Radioisotopes / Q000302:isolation & purification* / Q000627:therapeutic use
chemical_list: D005290:Ferric Compounds; D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; C021024:ferric hydroxide; D017886:Durapatite