title: Synthetic studies to improve the deuterium labelling in nucleosides for facilitating structural studies of large RNAs by high-field NMR spectroscopy.
abstract: Synthetic studies to prepare ribonucleosides deuterated at C2' and the application of the developed procedures for the synthesis of 2H5-ribonucleosides from 1,2-O-isopropylidene-3-O-benzyl-ribofuranose-3,4,5,5'-2H4 have been reported.
authors.affiliation: Department of Bioorganic Chemistry, Box 581, Biomedical Center, University of Uppsala, S-751 23 Uppsala, Sweden.
authors.forename: M K
authors.initials: MK
authors.lastname: Kundu
authors.forename: A
authors.initials: A
authors.lastname: Trifonova
authors.forename: Z
authors.initials: Z
authors.lastname: Dinya
authors.forename: A
authors.initials: A
authors.lastname: Földesi
authors.forename: J
authors.initials: J
authors.lastname: Chattopadhyaya
mesh_terms: D003562:Cytidine / Q000031:analogs & derivatives; D003903:Deuterium / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D012313:RNA / Q000737:chemistry*; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D012263:Ribonucleosides; D003562:Cytidine; D012313:RNA; D003903:Deuterium