title: Changes in the central nervous system during long-duration space flight: implications for neuro-imaging.
abstract: The purpose of this paper is to review the potential functional and morphological effects of long duration space flight on the human central nervous system (CNS) and how current neuroimaging techniques may be utilized to study these effects. It must be determined if there will be any detrimental changes to the CNS from long term exposure to the space environment if human beings are to plan interplanetary missions or establish permanent space habitats. Research to date has focused primarily on the short term changes in the CNS as the result of space flight. The space environment has many factors such as weightlessness, electromagnetic fields, and radiation, that may impact upon the function and structure of the CNS. CNS changes known to occur during and after long term space flight include neurovestibular disturbances, cephalic fluid shifts, alterations in sensory perception, changes in proprioception, psychological disturbances, and cognitive changes. Animal studies have shown altered plasticity of the neural cytoarchitecture, decreased neuronal metabolism in the hypothalamus, and changes in neurotransmitter concentrations. Recent progress in the ability to study brain morphology, cerebral metabolism, and neurochemistry in vivo in the human brain would provide ample opportunity to investigate many of the changes that occur in the CNS as a result of space flight. These methods include positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI).
authors.affiliation: Division of Nuclear Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Newberg
authors.forename: A
authors.initials: A
authors.lastname: Alavi
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology / Q000528:radiation effects; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology / Q000528:radiation effects; D002490:Central Nervous System / Q000502:physiology* / Q000528:radiation effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009473:Neuronal Plasticity / Q000502:physiology / Q000528:radiation effects; D013026:Space Flight; D018489:Space Motion Sickness / Q000473:pathology; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014893:Weightlessness / Q000009:adverse effects*