[Effects of freezing and hypoxia on serum creatine kinase activity in rats].
Serum creatine kinase (CK) activity after cold exposure in rats acclimated to cold, hypoxia, or combined factors (both cold and hypoxia) were observed under normoxic [correction of normoxie] and hypoxic condition in order to study the degrees of damage to the tissues. The results showed that resistance to frostbite increased in rats acclimated to cold; resistance to frostbite decreased markedly in rats acclimated to hypoxia, i.e. negative cross-acclimation exists between hypoxia and cold. The changes in serum CK activity in rats exposed to both cold and hypoxia for 4 weeks were essentially the same as those in hypoxia-acclimated rats, and were different significantly from those in cold-acclimated rats. It indicates that the effects of hypoxic exposure were stronger than those of cold exposure, its mechanism remains an area for further study.
Liu
J
J
Institute of Hygiene and Environmental Medicine, Academy of Military Medical Sciences, Tianjin, China.
Zhang
Z
Z
Yang
Z
Z
Li
F
F
Yan
P
P
Liu
Y
Y
D000064:Acclimatization / Q000502:physiology*; D000222:Adaptation, Physiological; D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood* / Q000378:metabolism; D005627:Frostbite; D007036:Hypothermia, Induced / Q000009:adverse effects; D000860:Hypoxia / Q000503:physiopathology*; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D003402:Creatine Kinase; D010100:Oxygen