title: Prolonged bed rest impairs response of the small arteries to cold pressor test.
abstract: Cold pressor test (CPT) has been known to increase vascular resistance through adrenergic stimulation. To assess the effect of prolonged bed rest (BR) on sympathetic neural control, blood flow velocity of the proper palmar digital artery (resistance vessel) was measured in 10 healthy volunteers during a 90 seconds CPT by pulsed Doppler ultrasound using a 7.5 MHz linear transducer before and after 20 days BR. Blood flow velocity in the proper palmar digital artery decreased during the first half of the CPT both before and after BR, but decreases in peak flow velocity became less prominent (p<0.05) after BR (-48+/-20%) than before bed rest (-61+/-25%). The only subject whose lower body negative pressure tolerance time was prolonged after BR showed prominent decreases in peak flow velocity during the first half of the CPT after BR. Peak flow velocity returned to the pre-test value during the latter half of the CPT in 7 subjects before BR, but in only 2 subjects after BR (p<0.05). Thus, 20 days BR impairs the response of the small digital arteries to CPT, suggesting that a decrease in a adrenergic stimulation occurs after prolonged BR.
authors.affiliation: The Second Department of Internal Medicine, University of Tokyo, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Takenaka
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Haruna
authors.forename: K
authors.initials: K
authors.lastname: Kuriyama
authors.forename: S
authors.initials: S
authors.lastname: Iwamoto
authors.forename: K
authors.initials: K
authors.lastname: Kawakubo
authors.forename: T
authors.initials: T
authors.lastname: Igarashi
authors.forename: M
authors.initials: M
authors.lastname: Omata
authors.forename: A
authors.initials: A
authors.lastname: Gunji
mesh_terms: D000293:Adolescent; D000328:Adult; D001158:Arteries / Q000000981:diagnostic imaging*; D001510:Bed Rest / Q000009:adverse effects*; D001783:Blood Flow Velocity; D003080:Cold Temperature; D005260:Female; D005385:Fingers / Q000098:blood supply / Q000000981:diagnostic imaging*; D006339:Heart Rate; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology*; D008150:Lower Body Negative Pressure; D008297:Male; D011187:Posture; D016683:Supine Position; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014463:Ultrasonography; D014655:Vascular Resistance / Q000502:physiology*