Constrained flexibility in PNA: DNA binding studies with bridged aminopropylglycyl PNA.
Introduction of methylene bridges in aegPNA and apgPNA molecules give rise to cyclic five and six membered ring structures. Synthesis of a new six membered cyclic PNA monomer, aminopipecolyl PNA (pipPNA) is reported. Incorporation of pipPNA into PNA oligomers and comparative binding with target DNA sequences is studied.
Lonkar
P S
PS
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India.
Kumar
V A
VA
Ganesh
K N
KN
D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*
D020135:Peptide Nucleic Acids; D004247:DNA