Synthesis and evaluation of prolyl carbamate nucleic acids (PrCNA).
Carbamate linked prolyl nucleic acids are obtained in high yield and purity under mild conditions in solution and solid phase. p-Nitrophenylchloroformate is used as the activating reagent for alcohol. Homooligomers of PrCNA do not bind to DNA. The introduction of this modification in PNA sequences destabilizes the triplexes, inspite of enhancement in the base stacking.
Meena
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India.
Kumar
V A
VA
Ganesh
K N
KN
D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002942:Circular Dichroism; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D002219:Carbamates; D020135:Peptide Nucleic Acids; D011392:Proline