Obstructive sleep apnea syndrome in a patient with medulloblastoma.
We present one adult patient with medulloblastoma who developed polysomnographically documented obstructive sleep apnea after posterior fossa surgery. The sleep apnea worsened in conjunction with clinical and imaging-confirmed neoplastic progression and clinically improved after craniospinal radiation therapy. Medulloblastoma or its surgical treatment has never before been implicated in a sleep-related breathing disorder. We discuss possible mechanisms for its occurrence and management implications.
Greenough
G
G
Sleep Disorders Center, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA.
Sateia
M
M
Fadul
C E
CE
D000328:Adult; D002528:Cerebellar Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000601:surgery; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior; D016371:Cranial Irradiation; D003399:Craniotomy; D003680:Deglutition Disorders / Q000209:etiology; D003907:Dexamethasone / Q000627:therapeutic use; D004322:Drainage; D004401:Dysarthria / Q000209:etiology; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D011175:Positive-Pressure Respiration; D011183:Postoperative Complications; D018714:Radiotherapy, Adjuvant; D020181:Sleep Apnea, Obstructive / Q000209:etiology* / Q000628:therapy; D014139:Tracheostomy
D003907:Dexamethasone