Dysregulation in neuroimmunopathology and perspectives of immunotherapy.
Dysregulation of neuroimmune connections is a primary or secondary pathogenic factor of some CNS diseases. Autoimmune aggression is typical of multiple sclerosis, Alzheimer's disease, and epilepsy, while dysregulation characterized by enhanced production of autoantibodies to neurotransmitters and activation of cell factors is characteristic of alcoholism and drug abuse. In experimental models of alcoholism and drug addiction, protective effects of antiserotonin antibodies are mediated by immune cells stimulated by these antibodies. These effects can be used in the therapy of various forms of neuroimmunopathology by the method of adoptive immunotherapy.
Evseev
V A
VA
Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow.
Davydova
T V
TV
Mikovskaya
O I
OI
D000544:Alzheimer Disease / Q000276:immunology / Q000473:pathology / Q000628:therapy; D000818:Animals; D002493:Central Nervous System Diseases / Q000276:immunology* / Q000473:pathology* / Q000628:therapy; D004827:Epilepsy / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology / Q000628:therapy; D015213:Neuroimmunomodulation / Q000276:immunology / Q000502:physiology