Treatment of hydroxychloroquine overdose.
Hydroxychloroquine overdoses are rarely reported with 7 previous cases found in the English medical literature. We report a case and review the literature. A 16-year-old girl ingested a handful of hydroxychloroquine 200mg, 30 minutes before presentation and presented with tachycardia (heart rate 110 beats/min), hypotension (systolic blood pressure 63 mm Hg), central nervous system depression, conduction defects (QRS = 0.14 msec), and hypokalemia (K = 2.1 meq/L). She was treated with fluid boluses and dopamine, oxygen, and potassium supplementation. Toxicologic tests confirmed the presence of hydroxychloroquine. The patient's hypotension resolved within 4.5 hours, serum potassium stabilized in 24 hours, and tachycardia gradually decreased over 3 days. Although hydroxychloroquine overdoses are very rare, life-threatening hypotension, conduction problems, and hypokalemia can occur within 30 minutes of ingestion. Symptoms are similar to chloroquine and treatment must be implemented quickly and should be modeled after experience with chloroquine overdoses. Treatment modalities need further study, but current recommendations are: (1) diazepam for seizures and sedation; (2) early intubation and mechanical ventilation; (3) epinephrine for treatment of vasodilation and myocardial depression; (4) potassium replacement with close monitoring of levels; (5) charcoal for gastrointestinal decontamination if ingestion occurred within an hour; (6) high dose diazepam for life-threatening symptoms, until more information becomes available. No value was found for serum alkalinization or extracorporeal methods of drug removal.
Marquardt
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California Poison Control System, Sacramento Division, Sacramento, CA 95817, USA.
Albertson
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D000293:Adolescent; D000322:Adrenergic Agonists / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000506:poisoning*; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002606:Charcoal / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D062787:Drug Overdose / Q000628:therapy; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D006886:Hydroxychloroquine / Q000506:poisoning*; D007008:Hypokalemia / Q000139:chemically induced / Q000628:therapy; D007022:Hypotension / Q000139:chemically induced / Q000628:therapy; D007440:Intubation; D011188:Potassium / Q000627:therapeutic use*; D012121:Respiration, Artificial; D013610:Tachycardia / Q000139:chemically induced / Q000628:therapy; D016896:Treatment Outcome
D000322:Adrenergic Agonists; D018501:Antirheumatic Agents; D002316:Cardiotonic Agents; D002606:Charcoal; D006886:Hydroxychloroquine; D003975:Diazepam; D011188:Potassium; D004298:Dopamine; D004837:Epinephrine