The effect of Lodronat(R) on development of osteoporosis in tail-suspended rats.
It has been recently revealed that deficient loading of the musculoskeletal apparatus gives rise to osteoporosis. It is also a common knowledge, that diphosphonate preparations are used to advantage in clinical practice to prevent and treat osteoporosis of varying etiology. In connection with the above an attempt was made to evaluate potentials of dichlormethylene diphosphonic acid (Lodronat(R), Boehringer Mannheim) as a countermeasure against osteoporosis in tail-suspended rats (micro-g simulation).
Durnova
G
G
Institute for Biomedical Problems, Moscow, Russia.
Ilyina-Kakueva
E
E
Morukov
B
B
D000818:Animals; D001846:Bone Development / Q000187:drug effects; D001862:Bone Resorption / Q000517:prevention & control; D004002:Clodronic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D019417:Hindlimb Suspension / Q000009:adverse effects*; D008297:Male; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D018474:Weightlessness Simulation / Q000009:adverse effects
D004002:Clodronic Acid