title: The stability of benzoyl peroxide by isothermal microcalorimetry.
abstract: Isothermal microcalorimetry may be used to determine kinetic and thermodynamic parameters for chemical reactions. This paper reports rate constants, determined as a function of temperature, and the activation enthalpy for the degradation of solid benzoyl peroxide as determined by isothermal microcalorimetry. Studies were conducted on aqueous suspension phase, solid benzoyl peroxide. In addition, supporting evidence is cited from work carried out in this laboratory on the solution phase degradation of benzoyl peroxide using UV-visible spectrophotometry. The activation energy obtained by microcalorimetry was E(a)=137.8+/-6.6 kJ mol(-1) and the activation energy obtained from UV-visible spectrophotometry was E(a)=112.7+/-4.2 kJ mol(-1).
authors.affiliation: Medway Sciences, NRI University of Greenwich, Medway University Campus, Chatham Maritime, Kent ME4 4TB, UK.
authors.forename: F
authors.initials: F
authors.lastname: Zaman
authors.forename: A E
authors.initials: AE
authors.lastname: Beezer
authors.forename: J C
authors.initials: JC
authors.lastname: Mitchell
authors.forename: Q
authors.initials: Q
authors.lastname: Clarkson
authors.forename: J
authors.initials: J
authors.lastname: Elliot
authors.forename: A F
authors.initials: AF
authors.lastname: Davis
authors.forename: R J
authors.initials: RJ
authors.lastname: Willson
mesh_terms: D001585:Benzoyl Peroxide; D002151:Calorimetry / Q000379:methods*; D004355:Drug Stability; D007700:Kinetics
chemical_list: D001585:Benzoyl Peroxide