Penetration of the nucleoside analogue abacavir into the genital tract of men infected with human immunodeficiency virus type 1.
The male genital tract is considered an anatomical reservoir during therapy for human immunodeficiency virus infection, because the blood-testis barrier may prevent antiretroviral drugs (e.g., the protease inhibitors ritonavir, saquinavir and nelfinavir) from entering the male genital tract. To our knowledge, there are currently no available data on the penetration of the nucleoside analogue abacavir into the male genital tract. Our report shows that abacavir has good penetration into the male genital tract.
van Praag
R M
RM
National Aids Therapy Evaluation Center, Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, Amsterdam, The Netherlands.
van Heeswijk
R P
RP
Jurriaans
S
S
Lange
J M
JM
Hoetelmans
R M
RM
Prins
J M
JM
D019380:Anti-HIV Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015224:Dideoxynucleosides / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D008297:Male; D018894:Reverse Transcriptase Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012661:Semen / Q000378:metabolism*; D000099227:Abacavir
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D018894:Reverse Transcriptase Inhibitors; D000099227:Abacavir