title: Carotid endarterectomy: can we select surgical candidates at high risk for stroke and low risk for perioperative complications?
abstract: DESPITE EVIDENCE OF the efficacy of carotid endarterectomy from the large randomized multicenter trials completed in the 1990s, the physician who treats patients with carotid artery stenosis still is faced with a difficult management decision. More recently, subgroup analyses have been conducted of asymptomatic and symptomatic patients enrolled in these trials to identify clinical and radiological factors that increase the rates of morbidity and mortality associated with surgery, as well as those that increase the risk of stroke without surgery. Knowledge of these factors is important to recommend the best course of action for the individual patient. In this article, we summarize the conclusions of some of the subgroup analyses from the major carotid endarterectomy trials.
authors.affiliation: Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, VA, USA.
authors.forename: G
authors.initials: G
authors.lastname: Lanzino
authors.forename: D
authors.initials: D
authors.lastname: Couture
authors.forename: A
authors.initials: A
authors.lastname: Andreoli
authors.forename: L R
authors.initials: LR
authors.lastname: Guterman
authors.forename: L N
authors.initials: LN
authors.lastname: Hopkins
mesh_terms: D016893:Carotid Stenosis / Q000401:mortality / Q000601:surgery*; D016894:Endarterectomy, Carotid / Q000379:methods*; D006801:Humans; D015337:Multicenter Studies as Topic; D018579:Patient Selection; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D020521:Stroke / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate