Collagen implant for treating stress urinary incontinence in women with urethral hypermobility.
OBJECTIVE
We evaluated the use of collagen in women with stress urinary incontinence and urethral hypermobility.


METHODS
We treated 90 patients with stress urinary incontinence and urethral hypermobility with 1 to 3 injections of Contigen implant (C. R. Bard, Inc., Covington, Georgia) between June 1996 and October 1998. Observations at 3, 6 and 12 months included continence grade, 7-day voiding diaries and quality of life questionnaires. Abdominal leak point pressure was determined at baseline and 12 months.


RESULTS
At the 6-month followup 68 patients remained in the study, of whom 30 (44%) were dry and 24 (35%) were improved. Of the 58 patients who reached the 12-month followup 19 (33%) were dry and 19 (33%) were improved. Considering all patients entered into the study at 6 months 30 (33%) were dry and 24 (27%) were improved. Of the original 90 patients 19 (21%) were dry and 19 (21%) were improved at 12 months. The probability of maintaining initial improvement for 12 months was 44%. The success of bulking agent therapy was not predicted by the initial incontinence grade. Improved continence grade correlated with improved leak point pressure.


CONCLUSIONS
This therapy is appropriate in women with urethral hypermobility who wish to avoid surgical risks and in those in whom surgery is ill advised.
Bent
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Greater Baltimore Medical Center, Baltimore, Maryland, USA.
Foote
J
J
Siegel
S
S
Faerber
G
G
Chao
R
R
Gormley
E A
EA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003094:Collagen; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D019736:Prostheses and Implants; D014522:Urethral Diseases / Q000150:complications*; D014550:Urinary Incontinence, Stress / Q000209:etiology* / Q000628:therapy*
C048470:glutaraldehyde-cross-linked collagen; D003094:Collagen