Identification and nucleotide sequence of HLA-A*03013.
We have identified a further HLA-A*03 allele, A*03013, in three unrelated Caucasoid individuals. The allele was initially detected by the polymerase chain reaction using sequence-specific primers (PCR-SSP) and was shown to differ from HLA-A*03011 by a single non-coding substitution of G to T at position 167 in exon 2 by DNA sequencing. The A*03013 bearing haplotype in one of the three individuals, was HLA-A*03013, B*07, Cw*0702, DRB1*1101, DRB3*0202, DQA1*05, DQB1*0301. The estimated phenotype and gene frequencies for A*03013 was <0.02% and <0.00007, respectively.
Guttridge
M G
MG
Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Cardiff, Wales, UK. martin.guttridge@wbs.nhs.uk
Darke
C
C
D001483:Base Sequence; D002675:Child, Preschool; D005787:Gene Frequency; D015791:HLA-A3 Antigen / Q000145:classification / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D012689:Sequence Homology, Nucleic Acid
D015791:HLA-A3 Antigen