Systemic administration of a water-soluble hexasulfonated C(60) (FC(4)S) reduces cerebral ischemia-induced infarct volume in gerbils.
Buckminsterfullerence and its derivatives have recently been shown to exhibit considerable in vivo biological activities. A water-soluble hexasulfonated C(60) (FC(4)S) has been shown to protect against oxidative stress. Neuroprotective effects of FC(4)S were investigated in the present study. Focal cerebral ischemia was produced by a permanent occlusion of the right middle cerebral artery in gerbils. Infarct volumes were determined by 2,3,5-triphenyltetrazolium chloride transcardiac perfusion 24 h after cerebral ischemia. Chronic pretreatment of FC(4)S (0.5 and 5.0 mg/kg/day, intraperitoneally for 2 weeks) significantly reduced the infarct volume (by 42% and 68%, respectively) when compared to that of the control group. Results revealed that chronic pretreatment of FC(4)S may protect the brain against focal cerebral ischemia.
Yang
D Y
DY
Chung-Shan Medical & Dental College, 402 Taiwan, Republic of, Taichung, China.
Wang
M F
MF
Chen
I L
IL
Chan
Y C
YC
Lee
M S
MS
Cheng
F C
FC
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D002244:Carbon / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D037741:Fullerenes; D005849:Gerbillinae; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008297:Male; D009043:Motor Activity; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D012995:Solubility; D013778:Tetrazolium Salts; D014867:Water
D016166:Free Radical Scavengers; D037741:Fullerenes; D018696:Neuroprotective Agents; D013778:Tetrazolium Salts; D014867:Water; D002244:Carbon; C009591:triphenyltetrazolium; C069837:fullerene C60