Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides.
Phosphorothioate (PS) oligodeoxynucleotides represent the class of antisense drugs most advanced in development and clinical testing. Exploitation of antisense oligonucleotide technology for development of rationally designed therapeutic drugs has presented a unique set of challenges, some of which relate to their pharmacokinetic behavior in vivo. Pharmacokinetic studies of PS oligodeoxynucleotides demonstrate that they are well absorbed from parenteral sites, rapidly distributed broadly to all peripheral tissues, do not cross the blood-brain barrier, and are eliminated primarily by slow metabolism in tissues. In general, the pharmacokinetic properties of this class of compounds appear to be largely driven by chemistry rather than sequence.
Geary
R S
RS
Isis Pharmaceuticals Inc, Carlsbad, CA 92008, USA. rgeary@isisph.com
Yu
R Z
RZ
Levin
A A
AA
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D020319:Oligodeoxyribonucleotides, Antisense / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011485:Protein Binding; D013873:Thionucleotides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D001798:Blood Proteins; D020319:Oligodeoxyribonucleotides, Antisense; D013873:Thionucleotides