Centrosome duplication: three kinases come up a winner!
Despite over one hundred years of research, the duplication of the centrosome is a poorly understood process. Three recent papers--exploring three different kinases--may have provided the answer.
Hinchcliffe
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University of Massachusetts Medical School, Department of Cell Biology, 377 Plantation Street, Worcester, Massachusetts 01605, USA.
Sluder
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D000818:Animals; D042846:CDC2-CDC28 Kinases; D029742:Caenorhabditis elegans Proteins; D002453:Cell Cycle / Q000502:physiology; D018385:Centrosome / Q000502:physiology*; D019927:Cyclin E / Q000378:metabolism / Q000502:physiology; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases / Q000378:metabolism* / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D009687:Nuclear Proteins / Q000378:metabolism; D009697:Nucleolus Organizer Region / Q000378:metabolism; D000090243:Nucleophosmin; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D036082:Receptor, EphA1
D029742:Caenorhabditis elegans Proteins; D019927:Cyclin E; D009687:Nuclear Proteins; D000090243:Nucleophosmin; D011494:Protein Kinases; C441620:Ttk protein, mouse; C429649:zyg-1 protein, C elegans; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D036082:Receptor, EphA1; D017346:Protein Serine-Threonine Kinases; D042846:CDC2-CDC28 Kinases; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases