Increased nitric oxide products in CSF in primary progressive MS may reflect brain atrophy.
Because nitric oxide (NO) is a putative mediator of oligodendrocyte damage in the primary progressive form of MS (PPMS), the authors analyzed the levels of NO oxidation products in CSF and plasma from 25 patients with PPMS and 15 controls. The levels of nitrite + nitrate (NOx) in CSF were fourfold higher in patients with PPMS than in controls (p < 0.001), whereas the concentrations in plasma were similar. These data suggests involvement of NO in nervous tissue damage in PPMS.
Peltola
J
J
Neuroimmunology Unit, Department of Neurology, Tampere University Hospital, Finland. jukka.peltola@tays.fi
Ukkonen
M
M
Moilanen
E
E
Elovaara
I
I
D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood / Q000134:cerebrospinal fluid*; D009566:Nitrates / Q000097:blood / Q000134:cerebrospinal fluid; D009569:Nitric Oxide / Q000097:blood / Q000134:cerebrospinal fluid*; D009573:Nitrites / Q000097:blood / Q000134:cerebrospinal fluid; D018709:Statistics, Nonparametric
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide