Biofilm formation: a clinically relevant microbiological process.
Microorganisms universally attach to surfaces and produce extracellular polysaccharides, resulting in the formation of a biofilm. Biofilms pose a serious problem for public health because of the increased resistance of biofilm-associated organisms to antimicrobial agents and the potential for these organisms to cause infections in patients with indwelling medical devices. An appreciation of the role of biofilms in infection should enhance the clinical decision-making process.
Donlan
R M
RM
Biofilm Laboratory, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. rld8@cdc.gov
D001419:Bacteria / Q000254:growth & development; D018441:Biofilms / Q000254:growth & development*; D002176:Candida albicans / Q000254:growth & development; D002408:Catheters, Indwelling / Q000382:microbiology*; D004866:Equipment Contamination; D004865:Equipment and Supplies, Hospital / Q000382:microbiology*; D006801:Humans