title: Synthesis and terminal functionalization of a polymerizable phosphatidylethanolamine.
abstract: We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such as biotin or N-(epsilon-maleimidocaproyl (EMC), to facilitate bioconjugation reactions. The lipid conjugate can be used to generate a multifunctional substrate-supported phospholipid film that is further stabilized via in-situ photocopolymerization.
authors.affiliation: Laboratory for Biomolecular Materials Research, Department of Surgery and Bioengineering, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors.forename: X L
authors.initials: XL
authors.lastname: Sun
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: J M
authors.initials: JM
authors.lastname: Orban
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.forename: E L
authors.initials: EL
authors.lastname: Chaikof
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry; D003432:Cross-Linking Reagents; D015195:Drug Design; D008567:Membranes, Artificial; D008863:Microspheres; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000179:Acrylates; D000180:Acrylic Resins; D003432:Cross-Linking Reagents; D008567:Membranes, Artificial; D010714:Phosphatidylethanolamines; D011108:Polymers; C006903:carbopol 940