Human parvovirus B19 in cord blood of premature infants.
We investigated whether intrauterine parvovirus B19 infection is associated with premature birth by evaluating parvovirus B19 antibodies and DNA in umbilical cord blood from 76 premature infants. We performed enzyme-linked immunoadsorbent (ELISA) and polymerase chain reaction (PCR) assays to detect B19-specific IgM antibodies and parvovirus DNA. No parvovirus DNA was detected in cord blood sera, and no sample was positive for anti-parvovirus B19 IgM antibodies. Parvovirus appears unlikely to lead to premature birth.
Koga
M
M
Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan.
Matsuoka
T
T
Katayama
K
K
Takeda
K
K
Nakata
M
M
Sase
M
M
Kato
H
H
Furukawa
S
S
D000914:Antibodies, Viral / Q000097:blood*; D004279:DNA, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000276:immunology / Q000821:virology*; D005315:Fetal Diseases / Q000821:virology; D005865:Gestational Age; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D007234:Infant, Premature; D007752:Obstetric Labor, Premature / Q000209:etiology; D010322:Parvoviridae Infections / Q000150:complications / Q000821:virology; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D011247:Pregnancy
D000914:Antibodies, Viral; D004279:DNA, Viral; D007070:Immunoglobulin A; D007075:Immunoglobulin M