Asymmetric synthesis of carbocyclic pyrimidine nucleosides via pi-allylpalladium complex.
Racemic and enantiomerically pure carbocyclic pyrimidine nucleosides were synthesized efficiently by a convergent approach using Trost nucleophilic addition of pi-allylpalladium complexes.
Shi
J
J
Pharmasset, Inc., Tucker, Georgia 30084, USA.
Schinazi
R F
RF
D000498:Allyl Compounds / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000498:Allyl Compounds; D009942:Organometallic Compounds; D011741:Pyrimidine Nucleosides; D010165:Palladium