Antimalarial drugs clear resistant parasites from partially immune hosts.
Circumstantial evidence in human malaria suggests that elimination of parasites by drug treatment meets higher success rates in individuals having some background immunity. In this study, using the rodent malaria model Plasmodium chabaudi, we show that drug-resistant parasites can be cleared by drugs when the host is partially immune.
Cravo
P
P
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Rd., Edinburgh EH9 3JT, United Kingdom.
Culleton
R
R
Hunt
P
P
Walliker
D
D
Mackinnon
M J
MJ
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002738:Chloroquine / Q000627:therapeutic use; D004195:Disease Models, Animal; D004351:Drug Resistance; D007114:Immunization; D008288:Malaria / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D015767:Mefloquine / Q000627:therapeutic use; D051379:Mice; D016788:Plasmodium chabaudi / Q000187:drug effects
D000962:Antimalarials; D002738:Chloroquine; D015767:Mefloquine