title: An assessment of galactic cosmic radiation quality considering heavy ion track structures within the cellular environment.
abstract: Beyond the magnetic influence of the Earth, the flux of galactic cosmic radiation (GCR) represents a radiological concern for long-term manned space missions.  Current concepts of radiation quality and equivalent dose are inadequate for accurately specifying the relative biological "efficiency" of low doses of such heavily ionising radiations, based as they are on the single parameter of Linear Energy Transfer (LET).  Such methods take no account of the mechanisms, nor of the highly inhomogeneous spatial structure, of energy deposition in radiation tracks.  DNA damage in the cell nucleus, which ultimately leads to the death or transformation of the cell, is usually initiated by electrons liberated from surrounding molecules by the incident projectile ion.  The characteristics of these emitted "delta-rays", dependent primarily upon the charge and velocity of the ion, are considered in relation to an idealised representation of the cellular environment.  Theoretically calculated delta-ray energy spectra are multiplied by a series of weighting algorithms designed to represent the potential for DNA insult in this environment, both in terms of the quantity and quality of damage.  By evaluating the resulting curves, and taking into account the energy spectra of heavy ions in space, a relative measure of the biological relevance of the most abundant GCR species is obtained, behind several shielding configurations.  It is hoped that this method of assessing the radiation quality of galactic cosmic rays will be of value when considering the safety of long-term manned space missions.
authors.affiliation: College of Aeronautics, Cranfield University, Bedfordshire, U.K.
authors.forename: P A
authors.initials: PA
authors.lastname: Craven
authors.forename: M J
authors.initials: MJ
authors.lastname: Rycroft
mesh_terms: D000465:Algorithms; D000535:Aluminum; D002477:Cells / Q000528:radiation effects; D003198:Computer Simulation; D003359:Cosmic Radiation / Q000009:adverse effects*; D007477:Ions; D018499:Linear Energy Transfer; D008962:Models, Theoretical; D011829:Radiation Dosage; D011835:Radiation Protection; D011853:Radiobiology / Q000379:methods; D018570:Risk Assessment
chemical_list: D007477:Ions; D000535:Aluminum