title: Large-scale manufacturing of all four 2'-deoxynucleosides via novel strategies including a chemo-enzymatic process.
abstract: A chemical synthesis of 2-deoxyribose-1-phosphate 2 and its enzymatic conversion into purine 2'-deoxynucleosides (dNus) are shown. Besides the chemo-enzymatic process for purine dNus, a modified process for practical dC preparation is also established. Consequently, a series of practical manufacturing processes of all four dNus have been realized via novel strategies.
authors.affiliation: Chemical Synthesis Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba 297-0017, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Komatsu
authors.forename: H
authors.initials: H
authors.lastname: Awano
authors.forename: H
authors.initials: H
authors.lastname: Tanikawa
authors.forename: K
authors.initials: K
authors.lastname: Itou
authors.forename: I
authors.initials: I
authors.lastname: Ikeda
mesh_terms: D011684:Purine Nucleosides / Q000138:chemical synthesis*; D011683:Purine-Nucleoside Phosphorylase / Q000737:chemistry*; D012267:Ribosemonophosphates / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011684:Purine Nucleosides; D012267:Ribosemonophosphates; C031302:2-deoxyribose 1-phosphate; D011683:Purine-Nucleoside Phosphorylase