title: Regression of high-grade gastric B-cell lymphoma after eradication of Helicobacter pylori.
abstract: Regression of high-grade gastric B-cell lymphoma after eradication of Helicobacter pylori with antibiotic therapy has recently been shown in a very small number of patients. We describe here a patient with a 5-cm polypoid gastric lymphoma, who received a 7-day course of triple therapy when the histopathology was unknown. A second endoscopic examination 4 weeks later showed partial tumor regression without biopsy evidence of malignancy. Endoscopic mucosectomy was performed 8 weeks after the initial diagnosis. Again, in the histological analysis of the specimen, no evidence of B-cell lymphoma could be found. To confirm that the original biopsies were from the same patient, DNA analyses were carried out which gave identical results. This case suggests that a subgroup of primary gastric B-cell lymphomas responds to eradication of H. pylori with antibiotic therapy.
authors.affiliation: Department of Surgery and Surgical Oncology, Robert Rössle Hospital, Humboldt University, Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Gretschel
authors.forename: M
authors.initials: M
authors.lastname: Hünerbein
authors.forename: H D
authors.initials: HD
authors.lastname: Foss
authors.forename: M
authors.initials: M
authors.lastname: Krause
authors.forename: P M
authors.initials: PM
authors.lastname: Schlag
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy* / Q000209:etiology*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000900:Anti-Bacterial Agents