[Effect of alpha-tryptophan on conditioning and behavior in rats with experimental pathology of the thyroid gland].
Effects of L-tryptophan on learning and behavior were studied in male rats with a deficit or excess of thyroid hormones. Learning was assessed in active avoidance paradigm, and behavior was estimated in the "open-field" test. It was found that L-tryptophan restored the capability of thyreoidectomized rats for acquisition and reproduction of the active avoidance reaction and increased the exploratory behavior of these rats in the open-field. In triiodothyronine treated rats, L-tryptophan eliminated a light stimulatory effects of thyroid hormones on the processes of formations and retention of the active avoidance reaction, increased the exploratory activity, but decreased grooming in the open-field.
Sapronov
N S
NS
Research Institute for Experimental Medicine, Russian Academy of Medical Sciences, St.-Petersburg.
Fedotova
Iu O
IuO
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D006980:Hyperthyroidism / Q000523:psychology*; D007037:Hypothyroidism / Q000523:psychology*; D008297:Male; D051381:Rats; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000494:pharmacology; D014364:Tryptophan / Q000494:pharmacology*
D014284:Triiodothyronine; D014364:Tryptophan