Inhibition of epidural scar tissue formation after spinal surgery: external irradiation vs. spinal membrane application.
OBJECTIVE
The scar tissue that forms after lumbar dissection is a severe complication and a cause of lumbar and radicular pain. It was recently shown that radiotherapy could inhibit peridural fibrosis after laminectomy. In this study, the efficiency of external irradiation was compared with spinal membrane application.


METHODS
Thirty male New Zealand rabbits underwent L5 laminectomy. Ten rabbits each received a single fraction of 900-cGy external irradiation administered by 9-MeV electron beam 24 h after the surgery. Ten other rabbits each had spinal membrane applied during laminectomy. The remaining 10 rabbits constituted the control group. All of the rabbits were killed 30 days after the laminectomy. Axial histologic sections through the laminectomy defect were evaluated. Each specimen was scored for the extent and density of fibrosis and arachnoidal adherence.


RESULTS
The extent and density of fibrosis and arachnoidal adherence differed significantly between the control group and the treatment groups (p < 0.05). However, the extent and density of fibrosis and arachnoidal adherence did not differ significantly between the spinal membrane and irradiation groups (p > 0.05).


CONCLUSIONS
This preliminary study showed that high-single-fraction/low-total-dose administered postoperatively can successfully inhibit postsurgical epidural fibrosis as effectively as applied spinal membrane.
Bora
H
H
Department of Radiation Oncology, Gazi University, Ankara, Turkey
Aykol
S V
SV
Akyürek
N
N
Akmansu
M
M
Ataoglu
O
O
D000818:Animals; D002452:Cell Count; D002921:Cicatrix / Q000517:prevention & control* / Q000532:radiotherapy; D005355:Fibrosis / Q000209:etiology / Q000517:prevention & control; D007796:Laminectomy / Q000009:adverse effects*; D008161:Lumbosacral Region; D008297:Male; D008566:Membranes / Q000637:transplantation; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control* / Q000532:radiotherapy; D011817:Rabbits; D011853:Radiobiology; D011897:Random Allocation; D000267:Tissue Adhesions / Q000473:pathology