Effect of antiserotonin antibodies on bioelectrical activity of sensorimotor cortex.
The effect of antiserotonin antibodies on basal electrocorticogram was studied in electrophysiological experiments on rats. Intracortical injection of 10 microg antiserotonin antibodies into the sensorimotor cortex induced epileptiform activity in this area. It is assumed that antiserotonin antibodies modulate activity of cortical neurons due to both binding serotonin molecules and interaction with serotonin receptors.
Igon'kina
S I
SI
Laboratory of Neuroimmunopathology, Laboratory of Pain Pathophysiology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Science, Moscow. 4909.g23@g23.relcom.ru
Kukushkin
M L
ML
Basharova
L A
LA
Vetrile
L A
LA
Mikovskaya
O I
OI
Evseev
V A
VA
D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D004594:Electrophysiology; D008297:Male; D009044:Motor Cortex / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000276:immunology* / Q000502:physiology*
D000906:Antibodies; D012701:Serotonin