title: Cardiopulmonary adaptation to weightlessness.
abstract: The lung is profoundly affected by gravity.  The absence of gravity (microgravity) removes the mechanical stresses acting on the lung paranchyma itself, resulting in a reduction in the deformation of the lung due to its own weight, and consequently altering the distribution of fresh gas ventilation within the lung.  There are also changes in the mechanical forces acting on the rib cage and abdomen, which alters the manner in which the lung expands.  The other way in which microgravity affects the lung is through the removal of the gravitationally induced hydrostatic gradients in vascular pressures, both within the lung itself, and within the entire body.  The abolition of a pressure gradient within the pulmonary circulation would be expected to result in a greater degree of uniformity of blood flow within the lung, while the removal of the hydrostatic gradient within the body should result in an increase in venous return and intra-thoracic blood volume, with attendant changes in cardiac output, stroke volume, and pulmonary diffusing capacity.  During the 9 day flight of Spacelab Life Sciences-1 (SLS-1) we collected pulmonary function test data on the crew of the mission.  We compared the results obtained in microgravity with those obtained on the ground in both the standing and supine positions, preflight and in the week immediately following the mission.  A number of the tests in the package were aimed at studying the anticipated changes in cardiopulmonary function, and we report those in this communication.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla 92093-0931, USA.
authors.forename: G K
authors.initials: GK
authors.lastname: Prisk
authors.forename: H J
authors.initials: HJ
authors.lastname: Guy
authors.forename: A R
authors.initials: AR
authors.lastname: Elliott
authors.forename: J B
authors.initials: JB
authors.lastname: West
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D002248:Carbon Monoxide / Q000378:metabolism; D002302:Cardiac Output / Q000502:physiology*; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D011653:Pulmonary Diffusing Capacity / Q000502:physiology; D012119:Respiration / Q000502:physiology*; D012129:Respiratory Function Tests; D013026:Space Flight; D013318:Stroke Volume / Q000502:physiology*; D016683:Supine Position; D014893:Weightlessness
chemical_list: D002248:Carbon Monoxide