Compositional and toxicological evaluation of the diazotrophic cyanobacterium, Cyanothece sp. strain ATCC 51142.
Compositional analyses of Cyanothece sp. strain ATCC 51142 showed high protein (50-60%) and low fat (0.4-1%) content, and the ability to synthesize vitamin B12.  The amino acid profile indicated that Cyanothece sp. was a balanced protein source.  Fatty acids of the 18:3n-3 type were also present.  Mineral analyses indicated that the cellular biomass may be a good source of Fe, Zn and Na.  Caloric content was 4.5 to 5.1 kcal g dry weight-1 and the carbon content was approximately 40% on a dry weight basis.  Nitrogen content was 8 to 9% on a dry weight basis and total nucleic acids were 1.3% on a dry weight basis.  Short-term feeding studies in rats followed by histopathology found no toxicity or dietary incompatibility problems.  The level of uric acid and allantoin in urine and tissues was low, suggesting no excess of nucleic acids, as sometimes reported in the past for a cyanobacteria-containing diet.  The current work discusses the potential implications of these results for human nutrition applications.
Schneegurt
M A
MA
Deparment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Arieli
B
B
McKeehen
J D
JD
Stephens
S D
SD
Nielsen
S S
SS
Saha
P R
PR
Trumbo
P R
PR
Sherman
L A
LA
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001426:Bacterial Proteins / Q000032:analysis; D018533:Biomass; D002241:Carbohydrates / Q000032:analysis; D000458:Cyanobacteria / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D004043:Dietary Fiber / Q000032:analysis; D018504:Ecological Systems, Closed; D005109:Extracellular Matrix; D005227:Fatty Acids / Q000032:analysis; D005502:Food / Q000633:toxicity*; D005527:Food, Fortified; D006801:Humans; D008021:Life Support Systems; D008055:Lipids / Q000032:analysis; D008903:Minerals / Q000032:analysis; D009584:Nitrogen / Q000032:analysis; D009696:Nucleic Acids / Q000032:analysis; D009753:Nutritive Value; D051381:Rats; D017207:Rats, Sprague-Dawley
D000596:Amino Acids; D001426:Bacterial Proteins; D002241:Carbohydrates; D004043:Dietary Fiber; D005227:Fatty Acids; D008055:Lipids; D008903:Minerals; D009696:Nucleic Acids; D009584:Nitrogen