title: Issues and problems for radiobiological research in space.
abstract: The uniqueness of the space radiation field creates specific problems in the evaluation of hazards to men and materials. Comprehensive measurements of all physical parameters are necessary but not sufficient.  Particular attention has to be paid to variables like solar flares by applying fast-responding active dosimetry. The assessment of biological consequences poses even more problems. There are no human data for the kinds of particles seen in space and they will presumably never be available. The only reasonable approach is therefore to use the information obtained for other radiations and check their applicability for the space situation. This involves both the study of fundamental processes in ground experiments as well as their verification in space missions. Special emphasis has to be laid on the modification of radiation effects by flight-dynamic factors and microgravity. Radiation protection guidelines for space flights cannot simply be transformed from existent regulations designed for radiation workers on earth but have to be tailored to the specific situation in space.
authors.affiliation: Strahlenzentrum der Justus-Liebig-Universitat, Giessen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Kiefer
mesh_terms: D000337:Aerospace Medicine; D000818:Animals; D002478:Cells, Cultured / Q000528:radiation effects*; D003359:Cosmic Radiation; D006224:Cricetinae; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D018499:Linear Energy Transfer; D009154:Mutation; D011853:Radiobiology; D012062:Relative Biological Effectiveness; D018570:Risk Assessment; D019445:Solar Activity; D013026:Space Flight; D015002:Yeast, Dried