Expression of the alpha1D subunit of the L-type voltage gated calcium channel in human liver.
Calcium channel blocker is useful for a variety of purposes and is effective for preventing hepatitis elicited by different inducers, suggesting its possible clinical application for treating hepatitis. The alpha1-subunit of the dihydropyridine-sensitive L-type calcium channel is a target of calcium channel blocker. For clinical application of calcium channel blocker, it is important to analyze the expression of the L-type calcium channel in the liver. However, the subtype of the L-type calcium channel alpha1-subunit expressed in the liver was not known. In the present study, the alpha1-subunit of the calcium channel expressed in human liver was systematically analyzed. The alpha1D subunit of the dihydropyridine-sensitive L-type voltage gated calcium channel is expressed relatively strongly in the liver and may play an important role in the liver.
Okamoto
T
T
Research Laboratories, Nippon Chemiphar Co., Ltd., 1-22 Hikokawato, Misato, Saitama 341-0005, Japan.
Jeong
S Y
SY
Takahashi
Y
Y
Baughman
K W
KW
Ogata
K
K
Goto
J
J
Kanazawa
I
I
D020746:Calcium Channels, L-Type / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008099:Liver / Q000378:metabolism*; D021122:Protein Subunits; D012313:RNA / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
D020746:Calcium Channels, L-Type; D021122:Protein Subunits; D012313:RNA