Robinlin: a novel bioactive homo-monoterpene from Robinia pseudoacacia L. (Fabaceae).
A bioactivity-directed fractionation of the ethanolic extracts of Robinia pseudoacacia L. (Fabaceae) afforded robinlin (1), a novel homo-monoterpene. The structure of 1 was elucidated by spectral analyses of the parent compound as well as its derivatives; 1 showed strong bioactivity in the brine shrimp lethality test (BST).
Tian
F
F
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, School of Science, Purdue University, West Lafayette, IN 47907, USA.
Chang
C J
CJ
Grutzner
J B
JB
Nichols
D E
DE
McLaughlin
J L
JL
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D039821:Monoterpenes; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D039821:Monoterpenes; D013729:Terpenes; C439164:robinlin