The ACVD task force on canine atopic dermatitis (VIII): is the epidermal lipid barrier defective?
In humans with atopic dermatitis (AD), it is suspected that the epidermal lipid barrier is abnormal because of combined insufficient extrusion of lipid-containing organelles into the superficial epidermal intercellular spaces as well as skin lipid metabolic defects. To date, studies investigating skin hydration and lipids in atopic dogs are scarce and unfortunately have yielded conflicting data. Whether or not dogs with AD exhibit dry skin and an inadequate stratum corneum barrier, therefore, remains the subject of speculation.
Olivry
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Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA. thierry_olivry@ncsu.edu
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D000818:Animals; D002463:Cell Membrane Permeability; D003876:Dermatitis, Atopic / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004817:Epidermis / Q000473:pathology* / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000502:physiology*; D012955:Societies, Medical; D014481:United States
D008055:Lipids