title: Cytarabine treatment of human T-lymphoid cells induces decreased HIV-1 receptor expression and reduced HIV-1 susceptibility.
abstract: Continuous cultivation of T-lymphoid C8166 cells in the presence of pharmacological relevant concentration of cytarabine (Ara-C) results in significantly decreased expression of CD4 and CXCR4 molecules, the major cellular receptor and co-receptor of T-lymphotropic HIV-1 isolates. This change in receptor expression leads to decreased susceptibility of Ara-C resistant cells to HIV-1 infection demonstrated by reduced binding and penetration of HI-virus.
authors.affiliation: Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt/M, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Gröschel
authors.forename: A
authors.initials: A
authors.lastname: Kaufmann
authors.forename: J
authors.initials: J
authors.lastname: Cinatl
authors.forename: H W
authors.initials: HW
authors.lastname: Doerr
authors.forename: J
authors.initials: J
authors.lastname: Cinatl
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D015704:CD4 Antigens / Q000096:biosynthesis / Q000235:genetics; D003561:Cytarabine / Q000494:pharmacology*; D015870:Gene Expression; D015497:HIV-1; D006801:Humans; D015728:Receptors, HIV / Q000096:biosynthesis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism / Q000821:virology
chemical_list: D000998:Antiviral Agents; D015704:CD4 Antigens; D015728:Receptors, HIV; D003561:Cytarabine