title: [Hierba del clavo (Geum chiloense) modifying cyclosporine levels: potential risk for transplanted people].
abstract: We report a 54 years old male that received a renal allograft without complications. One year after the transplantation, she was receiving cyclosporine doses of 2 to 3 mg/kg and maintained serum levels of 60 to 90 mg/dl. An abrupt increase in cyclosporine serum levels to 469 and 600 mg/dl was noted after 15 months of transplantation. After a careful interrogation the patient admitted the use of Geum chiloense ("hierba del clavo"). Discontinuing this herbal remedy, cyclosporine levels decreased to 55 mg/dl, despite the maintenance of the same cyclosporine dose. The potential side effects of herbal remedies must be borne in mind.
authors.affiliation: Facultad de Medicina Universidad de Valparaíso, Servicio de Medicina Hospital Naval Almirante Nef.
authors.forename: J
authors.initials: J
authors.lastname: Duclos
authors.forename: H
authors.initials: H
authors.lastname: Goecke
mesh_terms: D016572:Cyclosporine / Q000378:metabolism* / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine