Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys.
The effect of Epithalon on melatonin and cortisol secretion in female rhesus monkeys of various ages was evaluated by enzyme immunoassay. Epithalon stimulated evening melatonin production and normalized circadian rhythms of cortisol production in old monkeys.
Goncharova
N D
ND
Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi. iprim@sochi.net
Khavinson
B K
BK
Lapin
B A
BA
D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone / Q000096:biosynthesis*; D008253:Macaca mulatta; D008550:Melatonin / Q000096:biosynthesis*; D009842:Oligopeptides / Q000494:pharmacology*
D000975:Antioxidants; D009842:Oligopeptides; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine; D006854:Hydrocortisone