GABA(A) receptor beta2/beta3 subunit and GAD67 immunoreactivity in the trigeminal motor nucleus during early postnatal development.
GABA neurotransmission plays a role in brainstem circuitry responsible for jaw movements. We investigated the developmental relationship between terminals expressing GAD67 and GABA(A) receptor beta(2)/beta(3) subunit expression within the trigeminal motor nucleus. GAD67 immunoreactivity was intense throughout development. Neuropilar beta(2)/beta(3) immunoreactivity emerged during the 2nd postnatal week. Our data provide anatomical evidence for a GABAergic innervation of neonatal trigeminal motoneurons and suggest that beta(2)/beta(3) subunit expression is developmentally regulated in trigeminal motoneurons.
Turman
J E
JE
Department of Biokinesiology and Physical Therapy, University of Southern California, 1540 Alcazar St., CHP155 Los Angeles, CA 90089, USA. turman@hsc.usc.edu
Rich
R A
RA
Chandler
S H
SH
D000818:Animals; D000833:Animals, Suckling; D000906:Antibodies; D005968:Glutamate Decarboxylase / Q000032:analysis* / Q000276:immunology; D007527:Isoenzymes / Q000032:analysis* / Q000276:immunology; D007568:Jaw / Q000294:innervation; D009046:Motor Neurons / Q000737:chemistry / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000032:analysis* / Q000276:immunology; D013391:Sucking Behavior; D014278:Trigeminal Nuclei / Q000166:cytology / Q000254:growth & development*
D000906:Antibodies; D007527:Isoenzymes; D011963:Receptors, GABA-A; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1