title: Polymer degradation and ultrafine particles:  potential inhalation hazards for astronauts.
abstract: When Teflon is heated the developing fumes produce in exposed human an influenza-like syndrome (polymer fume fever) or also severe toxic effects like pulmonary edema, pneumonitis and death.  The decomposition products and the resulting health effects are temperature-dependent.  The toxic effects seem to be related to the ultrafine particulate fraction of the fume.  To test the hypothesis that exposure to ultrafine particles results in an increased interstitialization of the particles which is accompanied by an acute pathological inflammation, rats were exposed to titanium dioxide (TiO2) particles by intratracheal instillation and by inhalation.  Both acute intratracheal instillation and subchronic inhalation studies on rats show that ultrafine TiO2 particles (approximately 20 nm diameter) access the pulmonary interstitium to a larger extent than fine particles (approximately 250 nm diameter) and that they elicit an inflammatory response as indicated by PMN increase in lavaged cells.  The release of ultrafine particles into the air of an enclosed environment from a thermodegradation event or from other sources is a potential hazard for astronauts.  Knowing the mechanisms of action is a prerequisite for technical or medical countermeasures.
authors.affiliation: School of Medicine & Dentistry, University of Rochester, NY 14642.
authors.forename: J
authors.initials: J
authors.lastname: Ferin
authors.forename: G
authors.initials: G
authors.lastname: Oberdörster
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D004785:Environmental Pollutants / Q000008:administration & dosage*; D007322:Instillation, Drug; D008168:Lung / Q000503:physiopathology; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000503:physiopathology*; D009504:Neutrophils / Q000502:physiology; D010316:Particle Size; D011138:Polytetrafluoroethylene; D051381:Rats; D011916:Rats, Inbred F344; D014025:Titanium / Q000008:administration & dosage / Q000633:toxicity*; D014132:Trachea
chemical_list: D004785:Environmental Pollutants; C009495:titanium dioxide; D011138:Polytetrafluoroethylene; D014025:Titanium