Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test.
Testing in an elevated plus-maze revealed dose-dependent anxiolytic activity of piracetam analog cycloprolylglycine. Intraperitoneal injection of this agent (0.05 mg/kg) 9-fold prolonged the time spent in open arms compared to the control, without affecting the total motor activity. This effect was stereo-selective: D-enantiomer in doses of 0.05 and 0.1 mg/kg was inactive. Therefore, cycloprolylglycine is similar to piracetam in not only nootropic, but also anxiolytic activity. The existence of an endogenous system responsible for the co-regulation of memory and anxiety is hypothesized.
Gudasheva
T A
TA
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. uusolari@solaris.msk.ru
Konstantinopol'skii
M A
MA
Ostrovskaya
R U
RU
Seredenin
S B
SB
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects; D018697:Nootropic Agents / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D051381:Rats; D013237:Stereoisomerism
D014151:Anti-Anxiety Agents; D018697:Nootropic Agents; D010456:Peptides, Cyclic; C062238:cyclo(prolylglycyl); D005998:Glycine