Nifs and Sufs in malaria.
This review assembles data from three bodies of literature (bacterial genetics, plastid biogenesis and parasitology) that seldom have much direct cross-talk. After overcoming terminological complications to sort out microbial nifS from sufS genes, we connect a bacterial operon, recently found to be involved in iron metabolism, the formation of [Fe-S] clusters and oxidative stress to a potentially important gene (sufB) carried on the degenerate plastid genome of malaria and related parasites.
Ellis
K E
KE
National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
Clough
B
B
Saldanha
J W
JW
Wilson
R J
RJ
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial; D017343:Genes, Plant; D017125:Genes, Protozoan; D008969:Molecular Sequence Data; D009876:Operon; D010961:Plasmodium / Q000235:genetics* / Q000378:metabolism; D018087:Plastids / Q000235:genetics*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D009626:Terminology as Topic
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D015800:Protozoan Proteins; C080001:nifS protein, Bacteria; C424569:ycf24 protein, E coli