title: Allergic contact dermatitis from sodium dihydroxycetyl phosphate, a new cosmetic allergen?
abstract: Sodium dihydroxycetyl phosphate (trade name Dragophos S 2/918501) was identified as a contact allergen in a herbal moisturizing cream causing severe acute contact dermatitis on the hands and face of a 41-year-old woman. Sodium dihydroxycetyl phosphate is a complex mixture of phosphate esters of dihydroxycetyl alcohol, and subsequent analysis and testing revealed hexadecane-1,2-diol as 1 of the allergenic ingredients. Another possible allergen in the compound appears to be hexadecane-1,2-diol, 2-isopropyl ether.
authors.affiliation: Department of Dermatology, Odense University Hospital, DK-5000 Odense C, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Lomholt
authors.forename: S C
authors.initials: SC
authors.lastname: Rastogi
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects* / Q000032:analysis; D003358:Cosmetics / Q000009:adverse effects* / Q000737:chemistry; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005148:Facial Dermatoses / Q000139:chemically induced; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009943:Organophosphorus Compounds / Q000009:adverse effects* / Q000737:chemistry; D010328:Patch Tests
chemical_list: D000485:Allergens; D003358:Cosmetics; C100378:Dragophos S; D009943:Organophosphorus Compounds