[Migration of neocortical neuroblasts in the rat embryo following multidose X-ray irradiation].
The study was designed to examine the process of neuroblast migration in rat embryonic neocortex after multi-dose X-ray irradiation in summary doses of 25, 50 and 75 cGy from the prenatal ontogenesis d 6 to d 18. Average content of nerve cells in the urinary bladder wall, thickness of cellular layers of developing cortex and the state of radial gliocyte processes were assessed by histological methods. Suppression of neuroblast migration not associated with structural disturbances of radial glia was found. The changes named are obviously the result of disorders of functional activity of cells of microenvironment and neuroblasts.
Chepur
E A
EA
Department of Human Anatomy, State Pediatric Medical Academy of St. Petersburg.
D000818:Animals; D002452:Cell Count; D002465:Cell Movement; D004307:Dose-Response Relationship, Radiation; D005260:Female; D018811:Maternal Exposure / Q000009:adverse effects*; D019579:Neocortex / Q000166:cytology / Q000196:embryology / Q000528:radiation effects*; D009474:Neurons / Q000502:physiology / Q000528:radiation effects*; D051381:Rats