Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells.
CD4(+)CD25(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-cell receptor, they downregulate the responses of CD25(-) effectors by a T-T interaction.
McHugh
R S
RS
Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Shevach
E M
EM
Thornton
A M
AM
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000276:immunology; D005756:Gastritis / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D051379:Mice; D009928:Organ Specificity / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015375:Receptors, Interleukin-2