title: [Does the addition of an anxiolytic drug improve the anti-emetic effectiveness of the steroid and granisetron combination in the prophylaxis of cisplatin-induced vomiting?].
abstract: Authors evaluated two forms of antiemetic therapy in 129 courses of 51 gynecological cancer patients treated with cisplatin chemotherapy of moderately or highly emetic dose (50-100 mg/m2) in a prospective, non randomized study. The patients received granisetron (3 mg, intravenously) and methylprednisolone (100 mg, orally) in the group A. An additional anxiolytic drug (alprazolam or meprobamate or diazepam) or droperidol with known sedative characteristics (1 ml, intravenously) was given in the combination of the group B. 80.3% and 73.5% complete responses were achieved in groups A and B, respectively (p = 0.4084). No differences were found in the side effects of the two antiemetic combinations. Authors conclude the addition of an anxiolytic drug does not improve the antiemetic effectivity of the granisetron-methylprednisolone combination in the first 24 hours of cisplatin chemotherapy.
authors.affiliation: Nógyógyászati Onkológiai Osztály, Országos Onkológiai Intézet, Budapest. lehoczky@oncol.hu
authors.forename: O
authors.initials: O
authors.lastname: Lehoczky
authors.forename: A
authors.initials: A
authors.lastname: Bagaméri
authors.forename: Z
authors.initials: Z
authors.lastname: Sárosi
authors.forename: T
authors.initials: T
authors.lastname: Kulcsár
authors.forename: T
authors.initials: T
authors.lastname: Pulay
mesh_terms: D000525:Alprazolam / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D004329:Droperidol / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy*; D017829:Granisetron / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008620:Meprobamate / Q000627:therapeutic use; D008875:Middle Aged; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000525:Alprazolam; D014151:Anti-Anxiety Agents; D000932:Antiemetics; D002945:Cisplatin; D003907:Dexamethasone; D003975:Diazepam; D004329:Droperidol; D017829:Granisetron; D008620:Meprobamate