Isoforms of thyroxin-binding globulin as markers of ecologically induced pathologies.
The content of thyroxin-binding globulin isoforms differing by the carbohydrate constituent is significantly increased in the blood of coronary patients and patients with insulin-dependent diabetes mellitus compared to normal and is comparable to that in cancer patients. Enhanced biosynthesis of abnormal proteins due to structural and functional reorganization of plasma membranes is probably responsible for accumulation of thyroxin-binding globulin isoforms.
Lapko
A G
AG
A. D. Sakharov International State Ecological University, Minsk. alapko@isir.minsk.by
Golovatyi
A S
AS
Kononko
O N
ON
Torbashevich
E S
ES
Milyutin
A A
AA
D000293:Adolescent; D000328:Adult; D001161:Arteriosclerosis / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D002462:Cell Membrane / Q000378:metabolism; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000097:blood*; D020033:Protein Isoforms; D013975:Thyroxine-Binding Proteins / Q000096:biosynthesis* / Q000737:chemistry*
D014408:Biomarkers, Tumor; D020033:Protein Isoforms; D013975:Thyroxine-Binding Proteins