Synthesis and study of a new series of phosphoramidate derivatives as mononucleotide prodrugs.
The synthesis and the study of new mononucleoside phosphoramidate diesters bearing S-acyl-2-thioethyl (SATE) groups and an alkylamino residue are reported. The studied compounds appear to be able to deliver the corresponding 5'-mononucleotide inside the cells, and could be considered as prototypes for a new kind of mononucleotide prodrugs (pronucleotides).
Egron
D
D
Laboratoire Coopératif Novirio-CNRS-Université Montpellier II, France.
Périgaud
C
C
Gosselin
G
G
Aubertin
A M
AM
Imbach
J L
JL
D000577:Amides / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D009711:Nucleotides / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology
D000577:Amides; D019380:Anti-HIV Agents; D009711:Nucleotides; D010756:Phosphoric Acids; D011355:Prodrugs; C011067:phosphoramidic acid