title: Microlesions: theory and reality.
abstract: Efforts to assess radiation risk in space have been complicated by the considerable unknowns regarding the biological effects of the heavy ion component (HZE particles) of the cosmic rays.  The attention has focused primarily on the assignation of a quality factor (Q) which would take into account the greater effectiveness of heavy ions vis-a-vis other forms of ionizing radiation.  If however, as the so-called "Microlesion Theory" allows, the passage of HZE particles through living tissue produces unique biological damage, the traditional use of Q becomes meaningless.  Therefore, it is critical to determine if microlesions, in fact, do exist.  While the concept does not necessarily require detectable morphological damage, "tunnel-lesions" or holes in ocular tissues have been cited as evidence of microlesions.  These data, however, are open to reinterpretation.  On-going light, scanning and transmission electron microscopic studies of the corneas, lenses and retinas of rat eyes exposed to 450 MeV/amu 56Fe ions thus far have not revealed tunnel-lesion damage.  The morphological effects of the heavy ions have been found to be qualitatively similar to the changes following other kinds of ionizing radiation.
authors.affiliation: Department of Ophthalmology, Columbia University, NY.
authors.forename: B V
authors.initials: BV
authors.lastname: Worgul
authors.forename: W
authors.initials: W
authors.lastname: Krebs
authors.forename: J P
authors.initials: JP
authors.lastname: Koniarek
mesh_terms: D000818:Animals; D003315:Cornea / Q000473:pathology / Q000528:radiation effects* / Q000648:ultrastructure; D003359:Cosmic Radiation / Q000009:adverse effects*; D004307:Dose-Response Relationship, Radiation; D005128:Eye Diseases / Q000209:etiology; D066298:In Vitro Techniques; D007477:Ions; D007908:Lens, Crystalline / Q000473:pathology / Q000528:radiation effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D012160:Retina / Q000473:pathology / Q000528:radiation effects* / Q000648:ultrastructure; D013026:Space Flight
chemical_list: D007477:Ions