title: Asymmetric inheritance of radial glial fibers by cortical neurons.
abstract: Recent studies demonstrated the neuronogenic role of radial glial cells (RGCs) in the rodent. To reveal the fate of radial glial processes, we intensively monitored divisions of RGCs in DiI-labeled slices from the embryonic day 14 mouse cortex. During RGC division, each pia-connected fiber becomes thin but is neither lost nor divided; it is inherited asymmetrically by one daughter cell. In divisions that produce a neuron and a progenitor, the neuron inherits the pial fiber, also grows a thick ventricular process for several hours, and is therefore indistinguishable from the progenitor RGC. The ventricular process in the radial glial-like neuron ("radial neuron") then collapses, leading to ascent of the neuron by using the "recycled" radial fiber.
authors.affiliation: Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, 351-0198, Saitama, Japan. tmiyata@brain.riken.go.jp
authors.forename: T
authors.initials: T
authors.lastname: Miyata
authors.forename: A
authors.initials: A
authors.lastname: Kawaguchi
authors.forename: H
authors.initials: H
authors.lastname: Okano
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D019521:Body Patterning / Q000502:physiology; D002451:Cell Compartmentation / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D048429:Cell Size / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D005333:Fetus; D007150:Immunohistochemistry; D051379:Mice; D008813:Mice, Inbred ICR; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016501:Neurites / Q000378:metabolism / Q000648:ultrastructure; D009457:Neuroglia / Q000166:cytology* / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D009924:Organ Culture Techniques; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins