title: A case of agranulocytosis associated with severe acute hepatitis B.
abstract: A 29-year-old male patient with acute hepatitis B developed agranulocytosis about 2 months after the clinical onset of the hepatitis. Bone marrow examination showed hypercellularity and maturation arrest of myeloid leukogenesis at the stage of metamyelocyte. Anti-neutrophil antibody was negative. Since the patient did not show spontaneous recovery for 2 months, the patient received granulocyte-colony stimulating factor, but the therapy was a very short course because he had an elevation of temperature and nausea. Sixty-eight days after admission, he was started on lithium carbonate at a dose of 600 mg per day. About 3 weeks later, peripheral granulocyte counts had recovered to normal level.
authors.affiliation: The Department of Internal Medicine, Japan Self Defense Forces Central Hospital, 1-2-24 Ikejiri Setagaya-ku, Tokyo, Japan
authors.forename: J -i.
authors.initials: J
authors.lastname: Iwamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Hakozaki
authors.forename: H
authors.initials: H
authors.lastname: Sakuta
authors.forename: S -i.
authors.initials: S
authors.lastname: Kobari
authors.forename: S
authors.initials: S
authors.lastname: Kayashima
authors.forename: T
authors.initials: T
authors.lastname: Fujioka
authors.forename: K -i.
authors.initials: K
authors.lastname: Ooba
authors.forename: T
authors.initials: T
authors.lastname: Shirahama