title: Diffusion tensor imaging study of subcortical gray matter in cadasil.
abstract: OBJECTIVE
  In cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), water diffusion changes suggestive of microstructural tissue alterations have been recently reported in abnormal- and normal-appearing white matter as seen on T2-weighted images. In the subcortical gray matter, typical lacunar infarcts are repeatedly observed. Whether microstructural tissue changes are also present outside these lesions within the putamen or thalamus remains unknown.
  
  
  METHODS
  We used diffusion tensor imaging, an MRI method highly sensitive to cerebral microstructure, in 20 CADASIL patients and 12 controls. Both the trace of the diffusion tensor [Tr(D)] and an anisotropic diffusion index (volume ratio) of diffusion were measured within the putamen and thalamus outside typical lacunar infarcts as detected on both T1- and T2-weighted images.
  
  
  RESULTS
  A significant increase in Tr(D) and a decrease in anisotropy were observed in the putamen and thalamus in patients. The right/left indices of Tr(D) in the thalamus, but not in the putamen, were strongly correlated with the corresponding indices calculated in the white matter of the centrum semiovale. In addition, the diffusion increase in the thalamus was positively correlated with Tr(D) and with the load of small deep infarcts within the white matter and negatively correlated with the Mini-Mental State Examination score.
  
  
  CONCLUSIONS
  Our results suggest that microstructural tissue alterations are present in the putamen and thalamus, outside the typical lacunar infarcts in CADASIL. In the thalamus, these microstructural changes appear constant and are even observed in asymptomatic subjects. Some of these thalamic changes appear to result from degeneration of thalamocortical pathways secondary to ischemic white matter damage. The importance of this degenerative phenomenon in the pathophysiology of CADASIL requires further investigation.
authors.affiliation: Unité Neuroimagerie Anatomo-Fonctionelle, INSERM U334, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Molko
authors.forename: S
authors.initials: S
authors.lastname: Pappata
authors.forename: J F
authors.initials: JF
authors.lastname: Mangin
authors.forename: C
authors.initials: C
authors.lastname: Poupon
authors.forename: K
authors.initials: K
authors.lastname: Vahedi
authors.forename: A
authors.initials: A
authors.lastname: Jobert
authors.forename: D
authors.initials: D
authors.lastname: LeBihan
authors.forename: M G
authors.initials: MG
authors.lastname: Bousser
authors.forename: H
authors.initials: H
authors.lastname: Chabriat
mesh_terms: D000704:Analysis of Variance; D016880:Anisotropy; D002544:Cerebral Infarction / Q000150:complications / Q000175:diagnosis; D015161:Dementia, Multi-Infarct / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D004058:Diffusion; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009483:Neuropsychological Tests; D011518:Proto-Oncogene Proteins / Q000235:genetics; D011699:Putamen / Q000473:pathology*; D011956:Receptors, Cell Surface; D013788:Thalamus / Q000473:pathology*
chemical_list: D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface