title: Detection of a novel t(6;15)(q21;q21) in a pediatric Wilms tumor.
abstract: We report a novel cytogenetic finding in a favorable histology Wilms tumor occurring in a 4-month-old boy. Karyotypic analysis demonstrated a t(6;15)(q21;q21) in all tumor cells examined. This was confirmed using fluorescence in situ hybridization analysis. Molecular analysis of this rearrangement may provide clues to understanding the pathobiology of Wilms tumor.
authors.affiliation: Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. conrad.fernandez@iwk.nshealth.ca
authors.forename: C V
authors.initials: CV
authors.lastname: Fernandez
authors.forename: V S
authors.initials: VS
authors.lastname: Lestou
authors.forename: J
authors.initials: J
authors.lastname: Wildish
authors.forename: C L
authors.initials: CL
authors.lastname: Lee
authors.forename: P H
authors.initials: PH
authors.lastname: Sorensen
mesh_terms: D020223:Chromosome Painting; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008297:Male; D011003:Ploidies; D014178:Translocation, Genetic / Q000235:genetics*; D014407:Tumor Cells, Cultured; D044465:White People / Q000235:genetics; D009396:Wilms Tumor / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy