title: The Ligand Gated Ion Channel database: an example of a sequence database in neuroscience.
abstract: Multiple comparisons of receptor sequences, or receptor subunit sequences, has proved to be an invaluable tool in modern pharmacological investigations. Although of outstanding importance, general sequence databases suffer from several imperfections due to their size and their non-specificity. Room therefore exists for expert-maintained databases of restricted focus, where knowledge of the research field helps to filter the huge amount of data generated. Accordingly, neuroscientists have designed databases covering several types of proteins, in particular receptors for neurotransmitters. Ligand-gated ion channels are oligomeric transmembrane proteins involved in the fast response to neurotransmitters. All these receptors are formed by the assembly of homologous subunits, and an unexpected wealth of genes coding for these subunits has been revealed during the last two decades. The Ligand Gated Ion Channel database (LGICdb) has been developed to handle this growing body of information. The database aims to provide only one entry for each gene, containing annotated nucleic acid and protein sequences.
authors.affiliation: Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
authors.forename: N
authors.initials: N
authors.lastname: Le Novère
authors.forename: J P
authors.initials: JP
authors.lastname: Changeux
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001923:Brain Chemistry; D030541:Databases, Genetic; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000235:genetics*; D008024:Ligands; D008969:Molecular Sequence Data; D009488:Neurosciences / Q000295:instrumentation / Q000379:methods*
chemical_list: D007473:Ion Channels; D008024:Ligands