title: [Hepatoprotective effect of granules of the dry extract obtained from Gentianopsis barbata (Froel) Ma].
abstract: The granulated dry extract from Gentianopsis barbata (Froel) Ma in a dose of 0.1 g/kg produced a pronounced therapeutic effect in rats with experimental toxic (tetrachloromethane) and drug-induced (tetracycline) hepatitis. The gentian extract improved the bile production and secretion functions of liver, normalized the protein, lipid, and pigment metabolism, and increased the antioxidant system activity in the test animals.
authors.affiliation: Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Sciences, ul. Sakh'yanova 6, Ulan-Ude, Buryatia, 670047 Russia.
authors.forename: S M
authors.initials: SM
authors.lastname: Nikolaev
authors.forename: A V
authors.initials: AV
authors.lastname: Tsyrenzhapov
authors.forename: Z G
authors.initials: ZG
authors.lastname: Sambueva
authors.forename: G G
authors.initials: GG
authors.lastname: Nikolaeva
authors.forename: G V
authors.initials: GV
authors.lastname: Ratnikova
authors.forename: L M
authors.initials: LM
authors.lastname: Tankhaeva
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D013752:Tetracycline
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D013752:Tetracycline