title: Lipoprotein lipase and cholesterol transfer activities of lean and obese Zucker rats.
abstract: Adult female lean and obese Zucker rats maintained under standard conditions were used for the estimation of plasma, liver and white adipose tissue (WAT) activity of lipoprotein lipase, plasma and liver hepatic lipase and plasma lecithin-cholesterol acyltransferase. No differences in plasma or tissue levels of lipoprotein lipase between lean and obese rats were detected, but the larger WAT size of the obese rats resulted in higher lipase activity per unit of rat weight. Hepatic lipase levels in plasma were higher in the obese, but in liver, the higher activity was found in lean rats. No significant differences were found for lecithin-cholesterol acyltransferase activity, except when the levels in the HDL fraction were expressed per unit of protein weight, showing lower activity in the obese rats. In conclusion, the essentially maintained enzyme activities in obese rat tissues suggest that they cannot explain the deficient lipoproteins processing of obese rats, and, consequently their dislipidaemia.
authors.affiliation: Centre de Recerca en Nutrició i Ciència dels Aliments, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Peinado-Onsurbe
authors.forename: M
authors.initials: M
authors.lastname: Blay
authors.forename: J
authors.initials: J
authors.lastname: Julve
authors.forename: J A
authors.initials: JA
authors.lastname: Fernández-López
authors.forename: X
authors.initials: X
authors.lastname: Remesar
authors.forename: M
authors.initials: M
authors.lastname: Alemany
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D005260:Female; D006949:Hyperlipidemias / Q000150:complications / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D008071:Lipoprotein Lipase / Q000097:blood / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D002785:Sterol O-Acyltransferase / Q000097:blood / Q000378:metabolism*; D013851:Thinness / Q000378:metabolism
chemical_list: D008075:Lipoproteins, HDL; D002785:Sterol O-Acyltransferase; D008049:Lipase; D008071:Lipoprotein Lipase