Role of IL-10 in allergen-specific immunotherapy and normal response to allergens.
Induction of specific unresponsiveness (tolerance/anergy) in peripheral T cells by interleukin-10 (IL-10) and recovery by cytokines from the tissue microenvironment represent two key steps in specific immunotherapy of allergy and in natural exposure to allergens in healthy individuals. IL-10 elicits anergy in T cells by selective inhibition of the CD28 costimulatory pathway and controls suppression and development of antigen-specific immunity.
Akdis
C A
CA
Swiss Institute of Allergy and Asthma Research (SIAF), 7270 Davos, Switzerland. akdisac@siaf.unizh.ch
Blaser
K
K
D000485:Allergens / Q000008:administration & dosage / Q000276:immunology*; D018106:CD28 Antigens / Q000378:metabolism; D017635:Clonal Anergy / Q000276:immunology; D003888:Desensitization, Immunologic; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000628:therapy; D016753:Interleukin-10 / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens; D018106:CD28 Antigens; D016753:Interleukin-10