title: Stupor from lamotrigine toxicity.
abstract: OBJECTIVE
  To report that acute lamotrigine poisoning may result in severe encephalopathy.
  
  
  METHODS
  A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.
  
  
  RESULTS
  LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels.
  
  
  CONCLUSIONS
  LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status.
authors.affiliation: Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: M
authors.initials: M
authors.lastname: Sbei
authors.forename: J V
authors.initials: JV
authors.lastname: Campellone
mesh_terms: D000927:Anticonvulsants / Q000506:poisoning* / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced*; D062787:Drug Overdose / Q000523:psychology; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology; D013406:Suicide, Attempted / Q000523:psychology*; D014227:Triazines / Q000506:poisoning* / Q000627:therapeutic use; D014635:Valproic Acid / Q000506:poisoning
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000077213:Lamotrigine