Synaptic transmission: exciting times for presynaptic receptors.
Presynaptic receptors play an important role - typically inhibitory--in modulating the strength of synaptic transmission in the brain. Recent studies now reveal that neurotransmitters can enhance synaptic strength by activating ligand-gated ion channels in presynaptic nerve endings.
Vitten
H
H
Department of Neuroscience, MC 0608 Basic Science Building, Room 3065, UCSD School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0608, USA.
Isaacson
J S
JS
D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D018118:Chloride Channels / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D005998:Glycine / Q000494:pharmacology; D015640:Ion Channel Gating / Q000502:physiology; D017729:Presynaptic Terminals / Q000187:drug effects / Q000502:physiology*; D018091:Receptors, AMPA / Q000502:physiology; D018009:Receptors, Glycine / Q000502:physiology*; D017661:Receptors, Presynaptic / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D013997:Time Factors
D015220:Calcium Channels; D018118:Chloride Channels; D018091:Receptors, AMPA; D018009:Receptors, Glycine; D017661:Receptors, Presynaptic; D005998:Glycine