Anthelmintic activity of essential oil of Ocimum sanctum and eugenol.
The essential oil of Ocimum sanctum and eugenol, tested in vitro, showed potent anthelmintic activity in the Caenorhabditis elegans model. Eugenol exhibited an ED(50) of 62.1 microg/ml. Eugenol being the predominant component of the essential oil, is suggested as the putative anthelmintic principle.
Asha
M K
MK
Bioassay Unit, Research and Development Centre, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Indl. Area, Hosur Road, Bangalore 561 229, India.
Prashanth
D
D
Murali
B
B
Padmaja
R
R
Amit
A
A
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects*; D005054:Eugenol / Q000494:pharmacology*; D006801:Humans; D018649:Ocimum basilicum; D009822:Oils, Volatile / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010938:Plant Oils / Q000494:pharmacology*
D000969:Antinematodal Agents; D009822:Oils, Volatile; D010938:Plant Oils; D005054:Eugenol