[Effects of cerebrospinal fluid preparation from male and female patients with opiate dependence on rat open-field behavior].
The effects of the intranasal administration of preparations made from the cerebrospinal fluid of male and female opiate users on the open-field rat behavior were studied. Behavioral differences were demonstrated in the effects of preparations from female and male cerebrospinal fluid. The administration of the "male" preparation produced a significant decrease in the locomotor activity and increase in the immobilization time and grooming duration, while the "female" preparation had the opposite effects. These differences may result from different content of endogenous and exogenous opiates and dopamine (and its metabolites) in the cerebrospinal fluid of male and female opiate users.
Ordian
N E
NE
Pavlov Institute of Physiology, Russian Academy of Sciences, Municipal Hospital No. 32, St.-Petersburg.
Nesterov
N N
NN
Vasil'ev
V Iu
VIu
Pirumov
P A
PA
rakitskaia
V V
VV
Tolstukhina
T I
TI
Kulikov
I B
IB
Shaliapina
V G
VG
D000818:Animals; D005260:Female; D006120:Grooming / Q000502:physiology*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009293:Opioid-Related Disorders / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors