Retinal degeneration under the effect of antibodies to recoverin.
Serious changes in the retina, diagnosed as retinal degeneration and uveitis, are observed only in the presence of high titers of antibodies to recoverin (Ca2+-binding protein, a paraneoplastic antigen) in the blood of rabbits. Negligible changes in the retina of rabbits with low antibody titers are detected only by cytohistochemical analysis of the retina. No changes in the retina develop in rabbits intravenously injected with antibodies to recoverin.
Bazhin
A V
AV
A. N. Belozerskii Institute of Physicochemical Biology, Moscow State University, Moscow.
Slepova
O S
OS
Tikhomirova
N K
NK
D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D002135:Calcium-Binding Proteins / Q000276:immunology*; D005136:Eye Proteins; D051597:Hippocalcin; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; D011817:Rabbits; D051603:Recoverin; D012160:Retina / Q000276:immunology / Q000473:pathology; D012162:Retinal Degeneration / Q000276:immunology* / Q000473:pathology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; D051603:Recoverin; D051597:Hippocalcin