[Compensating and reactivating effects of quinpirole on extinction of conditioned response and amnesia in mice with alternative behavioral stereotypes].
The effect of quinpirole on the passive avoidance habit retention in male C57BL/6J mice with aggressive and submissive behavioral strategies was studied during the habit extinction and amnesia. It was found that the activation of D2 dopamine postsynaptic receptors by quinpirole injections (1 mg/kg, i.p.) prolonged the passive avoidance retrieval during extinction in the submissive mice, while not affecting the basically high memory retrieval level in the aggressors. Under the amnesia conditions, quinpirole reactivated the passive avoidance retrieval irrespective of the base initial behavior status (aggressive versus submissive). It is concluded that the different basic state of the dopaminergic activity in mice predetermines the compensating-reactivating effect of quinpirole.
Dubrovina
N I
NI
Laboratory of Memory Regulation Mechanisms, Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences, ul. Timakova, 4, Novosibirsk, 630117 Russia.
Popova
E V
EV
Il'iuchenok
R Iu
RIu
D000374:Aggression; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D018491:Dopamine Agonists / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D019257:Quinpirole / Q000494:pharmacology*; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects*
D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2; D019257:Quinpirole