title: The first dedicated Life Sciences mission--Spacelab 4.
abstract: Spacelab is a large versatile laboratory carried in the bay of the Shuttle Orbiter. The first Spacelab mission dedicated entirely to Life Sciences is known as Spacelab 4. It is scheduled for launch in late 1985 and will remain aloft for seven days. This payload consists of 25 tentatively selected investigations combined into a comprehensive integrated exploration of the effects of acute weightlessness on living systems. An emphasis is placed on studying physiological changes that have been previously observed in manned space flight. This payload has complementary designs in the human and animal investigations in order to validate animal models of human physiology in weightlessness. The experimental subjects include humans, squirrel monkeys, laboratory rats, several species of plants, and frog eggs. The primary scientific objectives include study of the acute cephalic fluid shift, cardiovascular adaptation to weightlessness, including postflight reductions in orthostatic tolerance and exercise capacity, and changes in vestibular function, including space motion sickness, associated with weightlessness. Secondary scientific objectives include the study of red cell mass reduction, negative nitrogen balance, altered calcium metabolism, suppressed in vitro lymphocyte reactivity, gravitropism and photropism in plants, and fertilization and early development in frog eggs. The rationale behind this payload, the selection process, and details of the individual investigations are presented in this paper.
authors.affiliation: Headquarters, National Aeronautics and Space Administration, Washington, DC 20546, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Cramer
authors.forename: D H
authors.initials: DH
authors.lastname: Reid
authors.forename: H P
authors.initials: HP
authors.lastname: Klein
mesh_terms: D000222:Adaptation, Physiological; D000337:Aerospace Medicine; D000818:Animals; D001690:Biological Science Disciplines; D002320:Cardiovascular Physiological Phenomena; D004911:Erythrocyte Volume; D018495:Fluid Shifts / Q000502:physiology; D006801:Humans; D009584:Nitrogen / Q000378:metabolism; D012107:Research Design; D012143:Respiratory Physiological Phenomena; D013026:Space Flight / Q000295:instrumentation* / Q000458:organization & administration*; D018489:Space Motion Sickness / Q000503:physiopathology; D018531:Spacecraft / Q000295:instrumentation*; D014893:Weightlessness
chemical_list: D009584:Nitrogen