title: Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives.
abstract: For the development of new anticancer agents, 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives were designed and evaluated for their topoisomerase I inhibitory activity and antitumor cytotoxicity. Structure-activity relationship studies indicated that 2,2':6',2"-terpyridine derivatives were highly cytotoxic toward several human tumor cell lines, whereas 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives were potent topoisomerase I inhibitors.
authors.affiliation: College of Pharmacy, Yeungnam University, Kyongsan 712-749, South Korea.
authors.forename: L X
authors.initials: LX
authors.lastname: Zhao
authors.forename: T S
authors.initials: TS
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Ahn
authors.forename: T H
authors.initials: TH
authors.lastname: Kim
authors.forename: E K
authors.initials: EK
authors.lastname: Kim
authors.forename: W J
authors.initials: WJ
authors.lastname: Cho
authors.forename: H
authors.initials: H
authors.lastname: Choi
authors.forename: C S
authors.initials: CS
authors.lastname: Lee
authors.forename: J A
authors.initials: JA
authors.lastname: Kim
authors.forename: T C
authors.initials: TC
authors.lastname: Jeong
authors.forename: C J
authors.initials: CJ
authors.lastname: Chang
authors.forename: E S
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011725:Pyridines; D059004:Topoisomerase I Inhibitors; C013278:2,2',2''-terpyridine