[A study on central and peripheral nerve transmitter mechanism of motion sickness].
Model of motion sickness (MS) was induced in rats by accelerating and decelerating vertical rotation for 60 min. The contents of Ach, NA, A and 5-HT and the activity of AchE in brain and blood of rats were examined after 60 min of rotation. The results showed: NA contents and AchE activity decreased significantly while A and 5-HT increased in rat's brain. Levels of Ach, NA and A in blood were increased. The results suggested that MS may be related to the imbalance of transmitters in the central nervous system resulting in the reduction of central arousal, and the imbalance between sympathetic and parasympathetic nerves.
Shen
Q
Q
Institute of Navigation Medicine, Nantong Medical College, China.
Wu
Y
Y
Ni
Z
Z
Li
B
B
D000109:Acetylcholine / Q000097:blood / Q000378:metabolism*; D000337:Aerospace Medicine; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D009041:Motion Sickness / Q000209:etiology / Q000503:physiopathology*; D018377:Neurotransmitter Agents / Q000097:blood / Q000378:metabolism; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D010275:Parasympathetic Nervous System; D051381:Rats; D017208:Rats, Wistar; D012399:Rotation / Q000009:adverse effects*; D013564:Sympathetic Nervous System
D018377:Neurotransmitter Agents; D000109:Acetylcholine; D009638:Norepinephrine