SNF4435C and D, novel immunosuppressants produced by a strain of Streptomyces spectabilis. II. Structure elucidation.
SNF4435C and D are new immunosuppressants isolated from the culture broth of a strain of Streptomyces spectabilis. Their molecular formulas were determined as C28H31NO6 based on the HRFAB-MS analyses. The structures of SNF4435C and D were elucidated to be novel nitrophenyl pyrones having an intriguing tricyclic ring system and diastereoisomers of each other by spectroscopic analyses including various NMR measurements.
Takahashi
K
K
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan. k-takahashi@snowbrand.co.jp
Tsuda
E
E
Kurosawa
K
K
D005285:Fermentation; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009574:Nitro Compounds / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry*; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
D007166:Immunosuppressive Agents; D009574:Nitro Compounds; D011753:Pyrones; C435067:SNF 4435C; C435066:SNF 4435D