Carnitine pretreatment can partially change the excitability of the immature nervous tissue.
The possible protective action of L-carnitine on neuronal excitability was studied in 21-day-old male Wistar rats with implanted electrodes. Administration of L-carnitine did not change the elicitation and duration of the epileptic seizures (cortical afterdischarges, ADs) in rats under normobaric oxygen atmosphere conditions. However, in animals exposed to 30 min hypobaric hypoxia the duration of the ADs was shortened after the second, fourth and sixth stimulation (in comparison with the first evoked ADs) while carnitine-treated rats retained their neuronal excitability and the duration of ADs was shortened only after the third stimulation.
Maresová
D
D
Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Rauchová
H
H
Jandová
K
K
Valkounová
I
I
Koudelová
J
J
Trojan
S
S
D000818:Animals; D001273:Atmosphere Exposure Chambers; D001921:Brain / Q000187:drug effects* / Q000254:growth & development* / Q000503:physiopathology; D002331:Carnitine / Q000494:pharmacology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D002331:Carnitine; D010100:Oxygen