[Predicting individual reactions to emotional stress and benzodiazepine tranquilizers].
The results of pharmacogenetic experiments revealed specificity of the emotional-stress reactions (ESR) in the inherited deterministic type of behavior and showed dependence of the benzodiazepine tranquilizer action on the ESR phenotype. Based on these data, we carried out experiments with a group of volunteers performing operator functions in a model of emotional-stress conditions. The results of these experiments allowed the operators to be divided into stress-resistant and stress-affected groups. The results of the data processing by methods of multidimensional statistics showed possibility of predicting the ESR phenotype and the qualitative effect of phenazepam (0.5 mg. p.o.) based on the individual topological and hormonal-biochemical characteristics of operators.
Seredenin
S B
SB
Laboratory of Pharmacogenetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Badyshtov
B A
BA
Neznamov
G G
GG
Makhnycheva
A L
AL
Kolotilinskaia
N V
NV
Nadorov
S A
SA
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment; D010597:Pharmacogenetics; D010641:Phenotype; D011379:Prognosis; D011597:Psychomotor Performance; D013315:Stress, Psychological / Q000097:blood / Q000235:genetics / Q000523:psychology*
D014151:Anti-Anxiety Agents; D006728:Hormones; D001569:Benzodiazepines