Human IgG1 and IgG4: the main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteins.
The Triatoma infestans salivary gland proteins (TSGP) can induce local and systemic hypersensitivity reactions in humans. IgG antibodies against TSGP were present in higher levels in sera of Chagas disease patients, and in individuals living in triatomine-infested areas than in controls living in triatomine-free areas. TSGP-specific IgG1 was found in sera of Chagas patients, and of individuals living in triatomine-infested rural areas, and uniquely specific IgG4 was present in sera of Chagas patients living in triatomine-infested areas, reactive against TSGP. Unique specificities were not detected in sera of individuals reacting against the ubiquitous mosquito Culex quinquifasciatus saliva proteins (CSGP). In conclusion, IgG1 reactive against TSGP is the main antibody present in individuals living in the triatomine-infested study areas. Also, IgG4 is found in the sera of insect-transmitted Chagas disease patients living in study areas.
Nascimento
R J
RJ
Chagas Disease Multidisciplinary Research Laboratory, Faculty of Medicine, University of Brasília, Federal District, Brazil.
Santana
J M
JM
Lozzi
S P
SP
Araújo
C N
CN
Teixeira
A R
AR
D000818:Animals; D015153:Blotting, Western; D001938:Brazil; D014355:Chagas Disease / Q000097:blood / Q000276:immunology*; D015331:Cohort Studies; D003465:Culex / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification / Q000276:immunology*; D019476:Insect Proteins / Q000276:immunology*; D008297:Male; D012424:Rural Population; D012469:Salivary Glands / Q000276:immunology*; D014224:Triatoma / Q000276:immunology*; D014505:Urban Population
D007074:Immunoglobulin G; D019476:Insect Proteins