CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor.
Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we identified a novel mammalian source of cAMP - soluble adenylyl cyclase (sAC) - that is regulated directly by bicarbonate ions (HCO(3)(-)). As the concentration of HCO(3)(-) reflects cellular levels of carbon dioxide (CO(2)), energy-generating metabolic processes (which increase intracellular CO(2)) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved mechanism of metabolic feedback regulation.
Zippin
J H
JH
Dept of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.
Levin
L R
LR
Buck
J
J
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D005075:Biological Evolution; D002245:Carbon Dioxide / Q000378:metabolism*; D000242:Cyclic AMP / Q000096:biosynthesis; D006706:Homeostasis; D006863:Hydrogen-Ion Concentration; D008660:Metabolism; D015398:Signal Transduction; D012995:Solubility
D001639:Bicarbonates; D002245:Carbon Dioxide; D000242:Cyclic AMP; D000262:Adenylyl Cyclases