title: Skeletal alterations in rats during space flight.
abstract: Male Wistar rats were placed in orbit for an 18.5 day period aboard the Soviet Cosmos 1129 biological satellite.  The skeletal changes which occurred during space flight were a reduced rate of periosteal bone formation in the tibial and humeral diaphyses, a decreased trabecular bone volume, and an increased fat content of the bone marrow in the proximal tibial metaphysis.
authors.affiliation: NASA-Ames Research Center, Mountain View, CA, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Wronski
authors.forename: E
authors.initials: E
authors.lastname: Morey-Holton
authors.forename: W S
authors.initials: WS
authors.lastname: Jee
mesh_terms: D000818:Animals; D001846:Bone Development / Q000502:physiology*; D001853:Bone Marrow / Q000378:metabolism; D018483:Diaphyses / Q000503:physiopathology; D006811:Humerus / Q000503:physiopathology*; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013026:Space Flight; D013977:Tibia / Q000503:physiopathology*; D014893:Weightlessness / Q000009:adverse effects*