Decreased platelet [3H]paroxetine binding sites in suicide attempters.
Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([3H]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [3H]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior.
Marazziti
D
D
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, via Roma, 67, 56100, Pisa, Italy. dmarazzi@psico.med.unipi.it
Dell'Osso
L
L
Rossi
A
A
Masala
I
I
Baroni
S
S
Armani
A
A
Giannaccini
G
G
Di Nasso
E
E
Lucacchini
A
A
Cassano
G B
GB
D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000503:physiopathology / Q000523:psychology; D002352:Carrier Proteins / Q000097:blood* / Q000502:physiology*; D015897:Comorbidity; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000503:physiopathology / Q000523:psychology; D008875:Middle Aged; D017374:Paroxetine / Q000493:pharmacokinetics; D011869:Radioligand Assay; D011955:Receptors, Drug / Q000097:blood*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins; D013406:Suicide, Attempted / Q000523:psychology*
D002352:Carrier Proteins; D011955:Receptors, Drug; D050486:Serotonin Plasma Membrane Transport Proteins; C092604:paroxetine receptor; D017374:Paroxetine