[Ligands of opioid and sigma receptors and correction of cardiac electrical instability in post-infarction cardiosclerosis].
Peripheral administration of the mu- or kappa-receptor agonists or sigma-receptor antagonists produced a significant receptor-dependent increase in the ventricular fibrillation threshold in rats with postinfarction cardiosclerosis. The effect was not observed upon administration of the epsilon-receptor agonist beta-endorphin. The receptor and molecular mechanisms of the observed effects are discussed.
Maslov
L N
LN
Laboratory of Experimental Cardiology, Institute of Cardiology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, ul. Kievskaya 111, Tomsk, 634050 Russia.
Lishmanov
Iu B
IuB
Naryzhnaia
N V
NV
Krylatov
A V
AV
Tam
S V
SV
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D004558:Electric Stimulation; D008024:Ligands; D009203:Myocardial Infarction / Q000150:complications*; D009206:Myocardium / Q000473:pathology*; D009292:Narcotic Antagonists; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000819:agonists / Q000187:drug effects*; D017473:Receptors, Opioid, kappa / Q000819:agonists / Q000037:antagonists & inhibitors; D017450:Receptors, Opioid, mu / Q000819:agonists / Q000037:antagonists & inhibitors; D017480:Receptors, sigma / Q000037:antagonists & inhibitors*; D012598:Sclerosis
D008024:Ligands; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma; C043460:epsilon receptor