title: Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patients.
abstract: BACKGROUND
  Oxidative stress in diabetes increases lipid peroxidation, which stimulates the development of atherosclerosis.
  
  
  METHODS
  We investigated in a 3-month placebo-controlled study with 19 normocholesterolemic type 2 diabetic patients whether treatment with 10-mg atorvastatin influenced antioxidants and reduced LDL oxidizability, assessed by in vitro production of conjugated dienes after copper-induced LDL oxidation.
  
  
  RESULTS
  The lag phase, as a measure of the resistance of LDL to oxidation, did not change (62.8+/-8.2 respectively 59.6+/-9.7 min, p=n.s.), while conjugated dienes decreased (512+/-74 respectively 487+/-50 nmol, p=0.012). Plasma alpha-tocopherol and ubiquinol levels decreased, while their ratios to LDL cholesterol remained stable.
  
  
  CONCLUSIONS
  Atorvastatin favourably influences some parameters of LDL oxidation. Whether this effect is clinically relevant remains to be determined.
authors.affiliation: Department of Endocrinology and Metabolism, University Hospital Maastricht, Maastricht, The Netherlands. Oranje@rdgg.nl
authors.forename: W A
authors.initials: WA
authors.lastname: Oranje
authors.forename: J P
authors.initials: JP
authors.lastname: Sels
authors.forename: G J
authors.initials: GJ
authors.lastname: Rondas-Colbers
authors.forename: P J
authors.initials: PJ
authors.lastname: Lemmens
authors.forename: B H
authors.initials: BH
authors.lastname: Wolffenbuttel
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism*; D000069059:Atorvastatin; D001786:Blood Glucose / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D004311:Double-Blind Method; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006538:Heptanoic Acids / Q000494:pharmacology*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000494:pharmacology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D000069059:Atorvastatin; D001786:Blood Glucose; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D006538:Heptanoic Acids; D008055:Lipids; D011758:Pyrroles; D014451:Ubiquinone; D014810:Vitamin E; C003741:ubiquinol