Causes and management of portal hypertension in the pediatric population.
Therapeutic options for children with portal hypertension now include a broad range of pharmacologic, endoscopic, and surgical procedures. Thoughtful application of all of these options can improve quality of life by decreasing the complications of portal hypertension and can decrease mortality by preventing the consequences of variceal hemorrhage. The development of portal hypertensive gastropathy following palliative procedures such as endoscopic sclerotherapy and band ligation may limit their long-term success in children. The excellent results now obtained with selective portosystemic shunts and liver transplantation assure that definitive surgical treatments will continue to be important components in the treatment of children with portal hypertensive complications or progressive liver disease. Evolving procedures, such as TIPS, represent excellent short-term life-preserving techniques to stabilize critically ill patients while awaiting liver transplantation. Their role in the future, long-term management of children is yet to be defined.
Ryckman
F C
FC
Department of Surgery, Division of Pediatric Surgery, University of Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. Ryckf0@chmcc.org
Alonso
M H
MH
D002675:Child, Preschool; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000601:surgery; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D008026:Ligation; D016031:Liver Transplantation; D008171:Lung Diseases / Q000150:complications; D011170:Portasystemic Shunt, Surgical; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D015911:Sclerotherapy