Human umbilical cord blood cells ameliorate Alzheimer's disease in transgenic mice.
Having had success in extending the life of mice with a transgene for amyotropic lateral sclerosis (SOD1) mice and Huntington's disease (Hdexon1), we administered megadoses of human umbilical cord blood mononuclear cells to mice with Alzheimer's disease. These mice have an over-expression of human Alzheimer amyloid precursor protein (APP), die early and develop a CNS disorder that includes neophobia. When given 110 x 10(6) human umbilical cord blood mononuclear cells, these mice (HuAPP 695.SWE) had considerable extension of life with a p value of 0.001 when compared to control animals.
Ende
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Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA.
Chen
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Ende-Harris
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D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001803:Blood Transfusion; D004195:Disease Models, Animal; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007231:Infant, Newborn; D007963:Leukocytes, Mononuclear / Q000637:transplantation*; D051379:Mice; D008822:Mice, Transgenic; D014183:Transplantation, Heterologous; D015431:Weight Loss
D016564:Amyloid beta-Protein Precursor