Two-dimensional (17)O multiple quantum magic-angle spinning NMR of organic solids.
We report two-dimensional (2D) (17)O multiple-quantum magic-angle spinning (MQMAS) NMR spectra for four (17)O-labeled organic compounds: [(17)O(2)]-D-alanine (1), potassium hydrogen [(17)O(4)]dibenzoate (2), [(17)O(4)]-D,L-glutamic acid.HCl (3) and [2,4-(17)O(2)]uracil (4). The high spectral resolution observed in the 2D (17)O MQMAS NMR spectra allows extraction of precise (17)O NMR parameters for all crystallographically distinct oxygen sites. We demonstrate that rotor synchronization is important in obtaining high-quality (17)O MQMAS spectra for organic compounds. Several issues related to the potential of (17)O MQMAS NMR for large biomolecular systems are also discussed.
Wu
G
G
Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6. gangwu@chem.queensu.ca
Dong
S
S
D000409:Alanine / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry*; D018698:Glutamic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D010103:Oxygen Isotopes; D014498:Uracil / Q000737:chemistry*
D001565:Benzoates; D010103:Oxygen Isotopes; D018698:Glutamic Acid; D014498:Uracil; D000409:Alanine