title: Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome.
abstract: Two families are presented in which siblings of children affected with Hallervorden-Spatz syndrome exhibited characteristic cranial magnetic resonance imaging changes before developing clinical features of the disease. Linkage to a major locus on chromosome 20p supported the diagnosis of Hallervorden-Spatz syndrome. In some patients with Hallervorden-Spatz syndrome, iron is radiographically evident before the onset of clinical symptoms.
authors.affiliation: Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97201, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Hayflick
authors.forename: J M
authors.initials: JM
authors.lastname: Penzien
authors.forename: W
authors.initials: W
authors.lastname: Michl
authors.forename: U M
authors.initials: UM
authors.lastname: Sharif
authors.forename: N P
authors.initials: NP
authors.lastname: Rosman
authors.forename: P G
authors.initials: PG
authors.lastname: Wheeler
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000235:genetics / Q000473:pathology*; D010375:Pedigree
chemical_list: D007501:Iron