title: Ninety-minute accelerated critical pathway for chest pain evaluation.
abstract: Rapid, efficient, and accurate evaluation of chest pain patients in the emergency department optimizes patient care from public health, economic, and liability perspectives. To evaluate the performance of an accelerated critical pathway for patients with suspected coronary ischemia that utilizes clinical history, electrocardiographic findings, and triple cardiac marker testing (cardiac troponin I [cTnI], myoglobin, and creatine kinase-MB [CK-MB]), we performed an observational study of a chest pain critical pathway in the setting of a large Emergency Department at the Veterans Affairs Medical Center in 1,285 consecutive patients with signs and symptoms of cardiac ischemia. The accelerated critical pathway for chest pain evaluation was analyzed for: (1) accuracy in triaging of patients within 90 minutes of presentation, (2) sensitivity, specificity, positive predictive value, and negative predictive value of cTnI, myoglobin, and CK-MB in diagnosing acute myocardial infarction (MI) within 90 minutes, and (3) impact on Coronary Care Unit (CCU) admissions. All MIs were diagnosed within 90 minutes of presentation (sensitivity 100%, specificity 94%, positive predictive value 47%, negative predictive value 100%). CCU admissions decreased by 40%. Ninety percent of patients with negative cardiac markers and a negative electrocardiogram at 90 minutes were discharged home with 1 patient returning with an MI (0.2%) within the next 30 days. Thus, a simple, inexpensive, yet aggressive critical pathway that utilizes high-risk features from clinical history, electrocardiographic changes, and rapid point-of-care testing of 3 cardiac markers allows for accurate triaging of chest pain patients within 90 minutes of presenting to the emergency department.
authors.affiliation: Department of Medicine, University of California, San Diego, California, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Ng
authors.forename: P
authors.initials: P
authors.lastname: Krishnaswamy
authors.forename: R
authors.initials: R
authors.lastname: Morissey
authors.forename: P
authors.initials: P
authors.lastname: Clopton
authors.forename: R
authors.initials: R
authors.lastname: Fitzgerald
authors.forename: A S
authors.initials: AS
authors.lastname: Maisel
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000209:etiology*; D002140:California; D002983:Clinical Competence; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D019091:Critical Pathways; D004562:Electrocardiography; D004636:Emergency Service, Hospital / Q000592:standards*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006787:Hospitals, Veterans; D006801:Humans; D007318:Inservice Training / Q000592:standards; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008505:Medical Staff, Hospital; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis*; D009211:Myoglobin / Q000097:blood; D019095:Point-of-Care Systems / Q000592:standards; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013997:Time Factors; D019210:Troponin I / Q000097:blood
chemical_list: D007527:Isoenzymes; D009211:Myoglobin; D019210:Troponin I; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form