Stereospecific synthesis of trans-arachidonic acids.
An effective synthesis is described for the preparation of all four mono trans isomers of arachidonic acid via deoxidation of epoxide precursors with lithium diphenylphosphide and quaternization with methyl iodide.
Krishna
U M
UM
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Reddy
M M
MM
Xia
J
J
Falck
J R
JR
Balazy
M
M
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D016718:Arachidonic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D001671:Biochemistry / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
D016718:Arachidonic Acid; C046783:11,12-epoxy-5,8,14-eicosatrienoic acid; C040776:5,6-epoxy-8,11,14-eicosatrienoic acid; C050715:8,9-epoxyeicosatrienoic acid; C046782:14,15-epoxy-5,8,11-eicosatrienoic acid; D015126:8,11,14-Eicosatrienoic Acid