title: DNA sequence recognition by NF kappa B p50 homodimer: strict and obscure recognition sites in the binding sequence.
abstract: 5-Formyl- and 5-(formylmethyl)-2'-deoxyuridines are introduced into a kappa B site instead of thymidine(s) in order to understand target sequence specificity of NF kappa B. It was found that one thymidine in the kappa B site is particularly important for the sequence specific recognition by NF kappa B.
authors.affiliation: Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kittaka
authors.forename: H
authors.initials: H
authors.lastname: Takayama
authors.forename: M
authors.initials: M
authors.lastname: Kurihara
authors.forename: C
authors.initials: C
authors.lastname: Horii
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Miyasaka
authors.forename: J
authors.initials: J
authors.lastname: Inoue
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D019281:Dimerization; D008958:Models, Molecular; D016328:NF-kappa B / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D052002:NF-kappa B p50 Subunit; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000378:metabolism; D013379:Substrate Specificity; D013936:Thymidine / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; D009841:Oligonucleotides; D013936:Thymidine