Association between 5-HT(2A) receptor polymorphism and psychotic symptoms in Alzheimer's disease.
BACKGROUND
The aim of this study is to analyze the segregation of the 102T/C polymorphism in the serotonin 2A receptor gene in patients affected by sporadic and familial Alzheimer's disease (FAD) with and without psychotic symptoms.


METHODS
The polymorphism was analyzed in 275 subjects. A semistructured interview was used to obtain information about delusions, hallucinations, and other specific behavioral signs occurring during the disease.


RESULTS
Fifty-two percent of AD patients with psychotic symptoms were homozygous for the C102 allele, as compared with 6.9% of AD patients without psychosis. Similarly, the C102/C102 genotype was significantly more frequent in FAD patients with psychosis than in FAD patients without (46.5% vs. 7.8%).


CONCLUSIONS
Our data strongly confirm and extend to FAD previous studies suggesting that the genetic variation at this locus is associated with prominent psychotic features in AD and that the 102C allele could play an important role in late-onset AD.
Nacmias
B
B
Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, Florence 50134, Italy.
Tedde
A
A
Forleo
P
P
Piacentini
S
S
Guarnieri
B M
BM
Bartoli
A
A
Ortenzi
L
L
Petruzzi
C
C
Serio
A
A
Marcon
G
G
Sorbi
S
S
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D015870:Gene Expression / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D017354:Point Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011618:Psychotic Disorders / Q000209:etiology / Q000235:genetics* / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000235:genetics* / Q000378:metabolism*
D001057:Apolipoproteins E; D011985:Receptors, Serotonin