Mouse models of metastatic pancreatic adenocarcinoma.
Pancreatic adenocarcinoma is a deadly disease. Its etiology is unknown, and metastatic disease kills the majority of patients who have it. Effective prevention is clearly the ultimate goal for eradicating this disease provided that the effects of environmental and genetic elements on pancreatic cancer development are fully understood. Currently, it appears that the control of pancreatic cancer metastasis is of immediate urgency. Fulfillment of this difficult task relies on knowledge of the cellular and molecular biology of metastasis. The use of relevant animal models will help define each aspect of this complicated process.
Xie
K
K
Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. kepxie@mail.mdanderson.org
Wang
B
B
Shi
Q
Q
Abbruzzese
J L
JL
Xiong
Q
Q
Le
X
X
D000230:Adenocarcinoma / Q000556:secondary / Q000628:therapy; D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D008647:Mesocricetus; D051379:Mice; D009368:Neoplasm Transplantation / Q000379:methods; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured