Topical tacrolimus in the treatment of bovine collagen hypersensitivity.
BACKGROUND
Soft tissue augmentation with bovine collagen is a common and safe aesthetic procedure. Despite adequate pretreatment testing, allergic reactions can develop. The medical literature provides little guidance to the clinician in the management of bovine collagen hypersensitivity.


OBJECTIVE
We describe a case of bovine collagen allergy treated with 0.1% topical tacrolimus and corticosteroids.


METHODS
Clinical evaluation and management of a patient with bovine collagen hypersensitivity.


RESULTS
Our patient responded to combined therapy with oral corticosteroids and topical tacrolimus.


CONCLUSIONS
Topical tacrolimus may be a useful first-line or adjuvant therapy in the management of bovine collagen allergic reactions. Further clinical experience with its use for bovine collagen hypersensitivity is required to determine its true efficacy in this condition.
Moody
B R
BR
Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sengelmann
R D
RD
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002417:Cattle; D003094:Collagen / Q000008:administration & dosage / Q000276:immunology*; D003357:Cosmetic Techniques; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy* / Q000276:immunology; D004359:Drug Therapy, Combination; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000188:drug therapy* / Q000276:immunology; D007267:Injections; D007428:Intradermal Tests; D011241:Prednisone / Q000008:administration & dosage; D019233:Retreatment; D016559:Tacrolimus / Q000008:administration & dosage*
D003094:Collagen; D011241:Prednisone; D016559:Tacrolimus