title: Role of co-repressors in transcriptional repression mediated by the t(8;21), t(16;21), t(12;21), and inv(16) fusion proteins.
abstract: The t(8;21), t(16;21), inv(16), and t(12;21) are some of the most frequent chromosomal translocations found in acute myeloid and acute lymphoblastic leukemia. The fusion proteins created by these chromosomal translocations are transcriptional repressors. A full understanding of the types of proteins that these fusion proteins recruit to repress transcription will not only clarify understanding of the molecular mechanism of action of these fusion proteins but also provide further targets for therapeutic intervention.
authors.affiliation: Department of Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 23rd and Pierce Avenue, Nashville, TN 37232, USA. scott.hiebert@mcmail.vanderbilt.edu
authors.forename: S W
authors.initials: SW
authors.lastname: Hiebert
authors.forename: B
authors.initials: B
authors.lastname: Lutterbach
authors.forename: J
authors.initials: J
authors.lastname: Amann
mesh_terms: D000208:Acute Disease; D050676:Core Binding Factor Alpha 2 Subunit; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000502:physiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D000075142:RUNX1 Translocation Partner 1 Protein; D012097:Repressor Proteins / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D014178:Translocation, Genetic; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; D000075142:RUNX1 Translocation Partner 1 Protein; D012097:Repressor Proteins; D014157:Transcription Factors; C107844:AML1-ETO fusion protein, human; C112643:AML1-MTG16 protein, human; C095514:CBFbeta-MYH11 fusion protein; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein