[Comparative study of chromatography-mass spectrography of microorganism's chemical markers in blood and intestinal mucosa bioptats].
Fatty acids, that are microorganism's markers in blood and jejunum's, ileum's, and large intestine's bioptats of the patients with irritable bowel syndrome were investigated with gas chromatography. Markers of Cl. perfringens, Cl. difficile, Enterococcus, Streptomyces, Enterobacterial, Klebsiella, E. coli, Peptostreptococcus, Candida Albicans, genus of Streptococcus, of Staphylococcus, of Fusobacterium sp and others microorganisms were revealed. Settling of intestinal mucosa was the same in jejunum, ileum and large intestine (0.5-1.3) x 10(10) cells/gr. and was approximately the same as microorganism's concentration in feces (1.8 x 10(11) cells/gr). Correlation of blood and bioptats markers was demonstrated in the most patients. The possibility to use specific fatty blood acids as microorganisms markers in preliminary diagnosis of mucosa microflora changes is discussed.
Osipov
G A
GA
Parfenov
A I
AI
Bogomolov
P O
PO
D001424:Bacterial Infections / Q000378:metabolism* / Q000382:microbiology; D015415:Biomarkers; D001706:Biopsy; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D007422:Intestines / Q000382:microbiology / Q000473:pathology
D015415:Biomarkers