Immune recognition. A new receptor for beta-glucans.
The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on macrophages and other white blood cells and activating them. Although beta-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another beta-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of beta-glucans.
Brown
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GD
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. gbrown@molbiol.ox.ac.uk
Gordon
S
S
D016475:3T3 Cells; D000818:Animals; D002176:Candida albicans / Q000378:metabolism; D005936:Glucans / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D037181:Lectins, C-Type; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D015054:Zymosan / Q000378:metabolism; D000099181:Dectin-1
D005936:Glucans; D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D015054:Zymosan; D000099181:Dectin-1; C045268:beta-glucan receptor