Biological stereoselective reduction of 3,3,5-trimethylcyclohexanone by Glomerella cingulata.
The microbial transformation of 3,3,5-trimethylcyclohexanone was investigated using the plant pathogenic fungus, Glomerella cingulata. With this organism 3,3,5-trimethylcyclohexanone gave the corresponding cis- and trans-3,3,5-trimethylcyclohexanols with the ratio of 20:1 forming the cis-isomer highly stereoselectively, upon 5 days incubation together with 3,3,5-trimethyl-2-cyclohexen-1-one (isophrone) as a minor product.
Okamura
S
S
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan.
Kameoka
H
H
Miyazawa
M
M
D001203:Ascomycota / Q000378:metabolism*; D001711:Biotransformation; D003512:Cyclohexanones / Q000378:metabolism*; D013237:Stereoisomerism
D003512:Cyclohexanones; C438457:3,3,5-trimethylcyclohexanone