title: Intracranial pressure dynamics during simulated microgravity using a new noninvasive ultrasonic technique.
abstract: It is believed that intracranial pressure (ICP) may be elevated in microgravity because a fluid shift toward the head occurs due to loss of gravitational blood pressures. Elevated ICP may contribute to space adaptation syndrome, because as widely observed in clinical settings, elevated ICP causes headache, nausea, and projectile vomiting, which are similar to symptoms of space adaptation syndrome. However, the hypothesis that ICP is altered in microgravity is difficult to test because of the invasiveness of currently-available techniques. We have developed a new ultrasonic technique, which allows us to record ICP waveforms noninvasively. The present study was designed to understand postural effects on ICP and assess the feasibility of our new device in future flight experiments.
authors.affiliation: Space Physiology Lab, NASA Ames Research Center, Moffett Field, CA 94035, USA.
authors.forename: T
authors.initials: T
authors.lastname: Ueno
authors.forename: R E
authors.initials: RE
authors.lastname: Ballard
authors.forename: L M
authors.initials: LM
authors.lastname: Shuer
authors.forename: W T
authors.initials: WT
authors.lastname: Yost
authors.forename: J H
authors.initials: JH
authors.lastname: Cantrell
authors.forename: A R
authors.initials: AR
authors.lastname: Hargens
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D005240:Feasibility Studies; D005260:Female; D018495:Fluid Shifts / Q000502:physiology; D006257:Head / Q000000981:diagnostic imaging; D018475:Head-Down Tilt; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D011187:Posture / Q000502:physiology*; D018617:Ultrasonography, Doppler, Pulsed / Q000379:methods*; D018474:Weightlessness Simulation