Dynamically assisted gated trapping for Fourier transform ion cyclotron mass spectrometry.
An efficient approach for trapping ions and enhancing signal based on 'adiabatic amplitude reduction' for Fourier transform ion cyclotron resonance (FTICR) mass spectrometry is described and evaluated. This method is a modification to the widely used gated trapping technique in which the trapping potential is raised adiabatically rather than instantaneously (non-adiabatically). Compared with non-adiabatic gated trapping, the final amplitudes of ion axial oscillations and energies are lower in the proposed method. All performance aspects of the FTICR spectrum (e.g., peak intensities, mass resolution, and mass accuracy) improve significantly compared to the conventional gated trapping technique.
Gorshkov
M V
MV
Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P.O. Box 999, Richland, WA 99352, USA.
Masselon
C D
CD
Anderson
G A
GA
Udseth
H R
HR
Smith
R D
RD
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010449:Peptide Mapping; D020543:Proteome; D012604:Scorpion Venoms / Q000737:chemistry* / Q000235:genetics; D012605:Scorpions / Q000235:genetics*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D014118:Toxins, Biological / Q000032:analysis
D020543:Proteome; D012604:Scorpion Venoms; D014118:Toxins, Biological