title: Endoscopic laser surgery for laryngeal cancer.
abstract: Endoscopic laser surgery is a novel treatment modality for laryngeal cancer. CO2 laser combined with an operating microscope is the most frequently used instrumentation. In Finland we started large-scale laser surgery in 1994 in all five university hospitals, covering a population of about five million people. By 1998 we had operated on 140 patients, of whom 11 were females. Eighty-three per cent of the lesions were glottic. Because of the low number of stage III-IV patients, the recurrence and survival analyses included 132 patients with in situ, stage I or stage II tumours, numbering 8, 96 and 28 respectively. The mean follow-up time was 38 months. The 2-year recurrence frequencies were 5% for stage I, 31% for stage II, and 11% altogether. No patients developed recurrences after 2 years. Seven patients underwent a salvage laryngectomy and the adjusted cumulative survival rate was 95%. After laser surgery the quality of voice was good or excellent in 70% and only three patients suffered from severe aphonia. This study showed that the results of endoscopic laser surgery are comparable with those of radiation therapy, but this type of treatment is more convenient for the patients and much cheaper for society.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Tampere, Medical School, Finland. Juhani.Pukander@uta.fi
authors.forename: J
authors.initials: J
authors.lastname: Pukander
authors.forename: J
authors.initials: J
authors.lastname: Kerälä
authors.forename: A
authors.initials: A
authors.lastname: Mäkitie
authors.forename: K
authors.initials: K
authors.lastname: Hyrynkangas
authors.forename: J
authors.initials: J
authors.lastname: Virtaniemi
authors.forename: R
authors.initials: R
authors.lastname: Grenman
mesh_terms: D000368:Aged; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy; D007828:Laryngoscopy; D053685:Laser Therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome