title: Damage to the photoreceptor cells of the rabbit retina from 56Fe ions:  effect of age at exposure, 1.
abstract: Optic and proximate tissues of New Zealand white (NZW) rabbits at ages (approximately 3.5 years) near the middle of their median lifespan (5-7 years) were given 0.5-3.5 Gy of 465 MeV u-1 56Fe ions in the Bragg plateau region of energy deposition at a linear energy transfer (LET infinity) of 220 +/- 31 keV micrometer-1.  Dose-dependent losses of retinal photoreceptor cells (rods) occurred until 1-2 years after irradiation, the period of this interim report.  Similar cumulative losses of photoreceptor cells were seen during the period 1-2 years post-irradiation for rabbits given comparable exposures when young (6-9 weeks old).  Since losses of photoreceptor cells at early times had not been determined previously, the current experiment, which was designed to simulate the responses of mature astronauts, redressed that deficiency.
authors.affiliation: Department of Radiological Health Sciences, Colorado State University, Fort Collins 80523, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Williams
authors.forename: J T
authors.initials: JT
authors.lastname: Lett
mesh_terms: D000367:Age Factors; D000818:Animals; D002386:Cataract / Q000209:etiology; D003359:Cosmic Radiation / Q000009:adverse effects*; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology; D004195:Disease Models, Animal; D007477:Ions; D007501:Iron; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D012062:Relative Biological Effectiveness; D017948:Retinal Rod Photoreceptor Cells / Q000528:radiation effects*
chemical_list: D007477:Ions; D007501:Iron