title: The dynamics of blood biochemical parameters in cosmonauts during long-term space flights.
abstract: Most of the previously obtained data on cosmonauts' metabolic state concerned certain stages of the postflight period. In this connection, all conclusions, as to metabolism peculiarities during the space flight, were to a large extent probabilistic. The purpose of this work was study  of  metabolism characteristics in cosmonauts directly during long-term space flights. In the capillary blood samples taken from a finger, by "Reflotron IV" biochemical analyzer, "Boehringer Mannheim" GmbH, Germany, adapted to weightlessness environments, the activity of GOT, GPT, CK, gamma-GT, total and pancreatic amylase, as well as concentration of hemoglobin, glucose, total bilirubin, uric acid, urea, creatinine, total, HDL- and LDL cholesterol, triglycerides had been determined. HDL/LDL-cholesterol ratio also was computed. The crewmembers of 6 main missions to the "Mir" orbital station, a total of 17 cosmonauts, were examined. Biochemical tests were carried out 30-60 days before launch, and in the flights different stages between the 25-th and the 423-rd days of flights. In cosmonauts during space flight had been found tendency to increase, in compare with basal level, GOT, GPT, total amylase activity,  glucose and total cholesterol concentration, and tendency to decrease of CK activity, hemoglobin, HDL-cholesterol concentration, and HDL/LDL - cholesterol ratio. Some definite trends in variations of other determined biochemical parameters had not been found. The same trends of mentioned biochemical parameters alterations observed in majority of tested cosmonauts, allows to suppose existence of connection between noted metabolic alterations with influence of space flight conditions upon cosmonaut's body. Variations of other studied blood biochemical parameters depends on, probably, pure individual causes.
authors.affiliation: State Scientific Center of Russian Federation, Institute of Biomedical Problems, Moscow, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Markin
authors.forename: L
authors.initials: L
authors.lastname: Strogonova
authors.forename: O
authors.initials: O
authors.lastname: Balashov
authors.forename: V
authors.initials: V
authors.lastname: Polyakov
authors.forename: T
authors.initials: T
authors.lastname: Tigner
mesh_terms: D000337:Aerospace Medicine; D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D001774:Blood Chemical Analysis / Q000295:instrumentation; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes; D008660:Metabolism; D013026:Space Flight; D014893:Weightlessness
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006454:Hemoglobins; D007527:Isoenzymes; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase