title: Effect of acute saline infusion on the cardiovascular deconditioning after 20-days head-down tilt bedrest.
abstract: Recent study showed that dehydration induced by prolonged exercise significantly impaired orthostatic tolerance with tachycardia and hypotension, and subsequent rehydration restored it. As physiological changes during exposure to actual or simulated microgravity can be viewed as dehydration process, we hypothesized that rehydration after prolonged bedrest may be a promising candidate to countermeasure not only fluid volume loss but also autonomic nervous deconditioning. Therefore, the purpose of present study was to determine the effect of acute rehydration by saline infusion on orthostatic cardiovascular deconditioning after bedrest.
authors.affiliation: Disabilities Research Division, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Haruna
authors.forename: K
authors.initials: K
authors.lastname: Takenaka
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kawakubo
authors.forename: A
authors.initials: A
authors.lastname: Gunji
mesh_terms: D001510:Bed Rest / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D018493:Cardiovascular Deconditioning / Q000187:drug effects*; D015444:Exercise / Q000502:physiology; D005440:Fluid Therapy; D018475:Head-Down Tilt; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy / Q000517:prevention & control; D007262:Infusions, Intravenous; D007866:Leg / Q000033:anatomy & histology / Q000502:physiology; D008150:Lower Body Negative Pressure; D008297:Male; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use*; D013610:Tachycardia / Q000188:drug therapy / Q000517:prevention & control; D018544:Weightlessness Countermeasures
chemical_list: D012965:Sodium Chloride