title: Altretamine for the treatment of metastatic renal cell carcinoma. A Hoosier Oncology Group trial.
abstract: Thirty patients with advanced renal cell carcinoma were treated on a phase 11 trial with altretamine. Altretamine was administered orally at a dosage of 260 mg/m2 days 1 through 14 with cycles repeated every 28 days. Nausea and vomiting were the most common toxicities. Ten percent (3 of 30) experienced Grade 3 gait abnormalities. None of the thirty evaluable patients achieved a complete or partial response. In summary, altretamine did not show antitumor activity in the treatment of advanced renal cell carcinoma.
authors.affiliation: Indiana University Cancer Center, Indianapolis 46202-5298, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Zon
authors.forename: J
authors.initials: J
authors.lastname: McClean
authors.forename: D
authors.initials: D
authors.lastname: Helman
authors.forename: R
authors.initials: R
authors.lastname: Ansari
authors.forename: J
authors.initials: J
authors.lastname: Picus
authors.forename: A
authors.initials: A
authors.lastname: Sandler
authors.forename: S D
authors.initials: SD
authors.lastname: Williams
authors.forename: P J
authors.initials: PJ
authors.lastname: Loehrer
mesh_terms: D000328:Adult; D000368:Aged; D006585:Altretamine / Q000009:adverse effects / Q000627:therapeutic use*; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D006585:Altretamine