[The effect of gamma-L-glutamylhistamine analogues on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome P450 system].
The influence of gamma-L-glutamylhistamine analogues on the hexenal-induced sleeping, glucocorticoid hormone content in blood plasma and severity of experimental anaphylactic reaction was studied. It was observed that gamma-L-glutamylhistamine analogues caused decrease in the sleeping time and severity of experimental anaphylactic reaction, the elevation of glucocorticoids content in blood plasma. The present results indicate that substances have the wide spectrum of biological activity which depends on the length of the N-acyl radical.
Nebol'sin
V E
VE
Lomonosov Moscow State Academy of Fine Chemical Tekhnology, Moskow, Russia.
Zheltukhina
G A
GA
Krzhechkovskaia
V V
VV
Kovaleva
V L
VL
Evstigneeva
R P
RP
D000707:Anaphylaxis / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005938:Glucocorticoids / Q000097:blood*; D006591:Hexobarbital / Q000494:pharmacology; D006632:Histamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D012890:Sleep / Q000187:drug effects
D005938:Glucocorticoids; D006993:Hypnotics and Sedatives; C013541:gamma-glutamylhistamine; D006632:Histamine; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital