title: Role of anticholinesterase mechanism in suppression of antibody formation during acute poisoning with organophosphorus compounds.
abstract: Experiments on Wistar rats showed that acute poisoning with organophosphorus compound dimethyl dichlorovinyl phosphate (0.5 LD(50)) was accompanied by two opposite effects: inhibition of acetylcholinesterase in T lymphocytes leading to suppression of thymus-dependent antibody formation (predominant effect) and acetylcholine-induced stimulation of antibody production. Acetylcholine activated acetylcholinesterase in intact T cells.
authors.affiliation: Saratov State Medical University.
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskii
authors.forename: V F
authors.initials: VF
authors.lastname: Kirichuk
authors.forename: V G
authors.initials: VG
authors.lastname: Germanchuk
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D006801:Humans; D062025:Organophosphate Poisoning; D011041:Poisoning / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000201:enzymology / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects; D013997:Time Factors
chemical_list: D002800:Cholinesterase Inhibitors; D000109:Acetylcholine