Fate of the grafted ovaries from female salamander Pleurodeles waltl embarked on the Cosmos 2229 flight.
The flight procedure of "Experience Triton" on Cosmos 2229 made necessary to sacrifice the embarked females just after landing.  In order to detect genetic abnormalities in the progency of these adult females, we have performed a surgical procedure based on the transplantation of an ovarian piece on a recipient animal.  One year later, as observed after laparotomy, the grafted ovaries exhibit oogonies and some growing oocytes.  In present time, out of 10 castrated and grafted adult females only one is still alive bearing a large grafted ovary.  Out of 5 castrated and grafted juvenile males, three are still alive, two of them exhibit a developing grafted ovary.  The grafted animals will be ready for mating within a few months.  Therefore, it will soon be possible to study the progeny of animals that have been submitted to space conditions.
Bautz
A
A
Laboratory of Experimental Biology-Immunology, Henri Poincaré University, Vandoeuvre-lès-Nancy, France.
Houillon
C h
Ch
Aimar
C
C
Mitashov
V
V
Dournon
C
C
D000818:Animals; D005260:Female; D007813:Laparotomy; D008297:Male; D009865:Oocytes / Q000502:physiology; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology* / Q000637:transplantation*; D010999:Pleurodeles / Q000254:growth & development / Q000502:physiology* / Q000601:surgery; D012426:Russia; D012726:Sexual Behavior, Animal / Q000502:physiology; D013026:Space Flight; D014893:Weightlessness