title: [Generalized pustulous psoriasis: A novel extraintestinal manifestation of Crohn's disease?].
abstract: A 66-year-old female patient suffering for 10 years from Crohn's disease firstly presented with a parallel outbreak of generalized pustulous psoriasis and Crohn's disease. A second synchronous exacerbation of both disorders occurred after discontinuation of treatment with prednisolone, methotrexate, and mesalazine. As to their pathogenetic concepts, both disease entities reveal similar immunologic alterations, i. e. comparable patterns of cytokines, chemokines, and inflammatory cells (T cells and neutrophils). Generalized pustulous psoriasis, therefore, might develop as hitherto undescribed, more rare extraintestinal manifestation of Crohn's disease.
authors.affiliation: Medizinische Klinik, Abteilung für Gastroenterologie und Hepatologie. ali-canbay@uni-essen.de
authors.forename: A
authors.initials: A
authors.lastname: Canbay
authors.forename: M
authors.initials: M
authors.lastname: Rünzi
authors.forename: R
authors.initials: R
authors.lastname: Gieseler
authors.forename: D
authors.initials: D
authors.lastname: Alamouti
authors.forename: G
authors.initials: G
authors.lastname: von Kobyletzki
authors.forename: M
authors.initials: M
authors.lastname: Stücker
authors.forename: H
authors.initials: H
authors.lastname: Goebell
authors.forename: P
authors.initials: P
authors.lastname: Altmeyer
mesh_terms: D000368:Aged; D018925:Chemokines / Q000097:blood; D003424:Crohn Disease / Q000175:diagnosis* / Q000276:immunology; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007958:Leukocyte Count; D009504:Neutrophils / Q000276:immunology; D011565:Psoriasis / Q000175:diagnosis* / Q000276:immunology; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D018925:Chemokines; D016207:Cytokines; D007166:Immunosuppressive Agents