title: Combination thrombolytic and anticoagulant therapy for bilateral renal vein thrombosis in a premature infant.
abstract: We report a premature infant with bilateral renal vein thrombosis and renal failure at 1 month of age who underwent treatment with recombinant tissue plasminogen activator and heparin sulfate. Combination thrombolytic and anticoagulation therapy was complicated by an intraventricular and intraparenchymal cerebral hemorrhage without resolution of the renal vein thrombosis. With increasing reports of successful use of this therapy for venous thrombosis, we suggest caution and continued study of its use in the premature infant and newborn.
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts University School of Medicine, Boston, Massachusetts, USA.
authors.forename: N
authors.initials: N
authors.lastname: Weinschenk
authors.forename: M
authors.initials: M
authors.lastname: Pelidis
authors.forename: J
authors.initials: J
authors.lastname: Fiascone
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012078:Renal Artery Obstruction / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D006493:Heparin; D010959:Tissue Plasminogen Activator