title: Bicyclic furo pyrimidine nucleosides with aryloxyphenyl and halophenyl substituted side chains as potent and selective varicella-zoster virus inhibitors.
abstract: The discovery of potent and selective inhibitors of VZV based on unusual bicyclic alkyl furo pyrimidine nucleosides has been recently reported. Modifications to the side-chain by addition of a phenyl group were found to further enhance the antiviral potency of these compounds. A series of alkoxyphenyl compounds (5a-5g) and two halophenyl derivatives (5h and 5i) were successfully synthesised and displayed anti-VZV activity at low microM concentrations.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, Cf10 3XF, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Blewett
authors.forename: C
authors.initials: C
authors.lastname: McGuigan
authors.forename: H
authors.initials: H
authors.lastname: Barucki
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011741:Pyrimidine Nucleosides