title: Deacetylravidomycin M, a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp. WK-6326. I. Taxonomy, fermentation, isolation and biological activities.
abstract: Streptomyces sp. WK-6326, a soil isolate, was found to produce an inhibitor of interleukin (IL)-4 signal transduction. Two structurally related compounds, a novel one designated deacetylravidomycin M and the known deacetylravidomycin, were isolated from the culture broth by solvent extraction, silica gel column chromatography and HPLC. Deacetylravidomycin M inhibited IL-4-induced CD23 expression in U937 cells without any cytotoxic effect, whereas deacetylravidomycin showed no inhibitory activity.
authors.affiliation: The Kitasato Institute, Kitasato University, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Tomoda
authors.forename: A
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: B H
authors.initials: BH
authors.lastname: Woodruff
authors.forename: N
authors.initials: N
authors.lastname: Ishiguro
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005285:Fermentation; D006801:Humans; D015847:Interleukin-4 / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D017455:Receptors, IgE; D015398:Signal Transduction / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D020298:U937 Cells
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D017455:Receptors, IgE; C435068:deacetylravidomycin M; D015847:Interleukin-4; C049540:desacetylravidomycin