Comparison of the contractile responses of human coronary bypass grafts and monkey arteries to human urotensin-II.
Human urotensin-II (hU-II) is a cyclic peptide recently cloned in humans and present in human cardiac tissue and human arteries. The effects of hU-II were studied on human coronary bypass grafts in vitro. In three out of eight human mammary arteries, and two out of three human radial arteries, hU-II caused contraction; human saphenous veins did not respond to hU-II. When it exists, the contraction slowly develops and has a low-to-moderate intensity. All radial arteries obtained from young healthy non-human primates contracted strongly to hU-II.
Paysant
J
J
Division of Angiology, Servier Research Institute, 11, rue des Moulineaux, 92150 Suresnes, France.
Rupin
A
A
Simonet
S
S
Fabiani
J N
JN
Verbeuren
T J
TJ
D000368:Aged; D000818:Animals; D001158:Arteries / Q000187:drug effects* / Q000502:physiology; D001026:Coronary Artery Bypass; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008252:Macaca fascicularis; D008297:Male; D008323:Mammary Arteries / Q000187:drug effects / Q000502:physiology; D017534:Radial Artery / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012501:Saphenous Vein / Q000187:drug effects / Q000502:physiology; D014579:Urotensins / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology
D014579:Urotensins; C029677:urotensin II