title: Changes in frequency of premature complexes and heart rate variability related to shift work.
abstract: OBJECTIVE
  To investigate whether an increased risk of cardiovascular disease might be caused by increased arrhythmogeneity and by unfavourable changes in autonomic cardiac control the changes in the occurrence of premature complexes (PVCs) and in heart rate variability (HRV) were studied in subjects who started to work in shifts.
  
  
  METHODS
  1 Year changes in frequency of PVCs and HRV were measured in 49 shift workers and 22 control subjects working in daytime. All respondents were starting in a new job in integrated circuit or waste incinerator plants.
  
  
  RESULTS
  The incidence of PVC increased significantly in shift workers over the 1 year follow up, compared with daytime workers. The frequency of ventricular extrasystoles increased in 48.9% of the shift workers, and in 27.3% of the daytime workers. The Spearman correlation coefficient between the number of nights worked and the change in PVCs was 0.33 (p=0.004). A small non-significant unfavourable change in HRV was found in both the shift and daytime workers.
  
  
  CONCLUSIONS
  A change in arrhythmogeneity, but not in cardiac autonomic control, might explain the increased risk of cardiovascular disease in shift workers.
authors.affiliation: Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands. Lgpm.vanamelsvoort@epid.unimaas.nl
authors.forename: L G
authors.initials: LG
authors.lastname: van Amelsvoort
authors.forename: E G
authors.initials: EG
authors.lastname: Schouten
authors.forename: A C
authors.initials: AC
authors.lastname: Maan
authors.forename: C A
authors.initials: CA
authors.lastname: Swenne
authors.forename: F J
authors.initials: FJ
authors.lastname: Kok
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology; D016022:Case-Control Studies; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D012044:Regression Analysis; D012307:Risk Factors; D018709:Statistics, Nonparametric; D018879:Ventricular Premature Complexes / Q000150:complications / Q000503:physiopathology*; D014940:Work Schedule Tolerance / Q000502:physiology*