title: Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae.
abstract: Propagation of Saccharomyces cerevisiae cells in conjugated linoleic acid (CLA) medium resulted in activation of the transcriptional machinery that responds to fatty acids. Cells utilized efficiently trans-10,cis-12 CLA, but not the corresponding cis-9,trans-11 isomer, probably due to the formation of cis-3,trans-5-dienoyl-CoA intermediates that are recalcitrant to beta-oxidation.
authors.affiliation: Institut für Biochemie und Molekulare Zellbiologie der Universität Wien and Ludwig Boltzmann-Forschungsstelle für Biochemie, Vienna, Austria. ag@abc.univie.ac.at
authors.forename: A
authors.initials: A
authors.lastname: Gurvitz
authors.forename: B
authors.initials: B
authors.lastname: Hamilton
authors.forename: H
authors.initials: H
authors.lastname: Ruis
authors.forename: A
authors.initials: A
authors.lastname: Hartig
authors.forename: J K
authors.initials: JK
authors.lastname: Hiltunen
mesh_terms: D019748:Carbon-Carbon Double Bond Isomerases / Q000378:metabolism; D019787:Linoleic Acid / Q000737:chemistry / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D019787:Linoleic Acid; D019748:Carbon-Carbon Double Bond Isomerases; C085575:delta(3,5),delta(2,4)-dienoyl-CoA isomerase