title: [Autoimmune cholangiopathy].
abstract: We report two patients with mixed characteristics of primary biliary cirrhosis and autoimmune hepatitis. They are two female patients in their fifties (54 and 58 years-old) one of them with autoimmune phenomenon, rheumatoid arthritis and Sjögren syndrome. Both of them showed laboratory values of cholestasis and the liver biopsy revealed liver cirrhosis with significant lesions of the bile ducts. They were treated with prednisolone with a rapid improvement and normalisation of their blood tests. They belong to a group called as overlap syndrome or autoimmune cholangitis with mixed characteristics, clinical, biochemical, immunological, and histopathologic overlapping between primary biliary cirrhosis and autoimmune hepatitis type I.
authors.affiliation: Unidade de Hepatologia do Serviço de Medicina 2, Serviço de Anatomia Patológica, Hospital de Santa Maria, Lisboa.
authors.forename: R
authors.initials: R
authors.lastname: Marinho
authors.forename: H
authors.initials: H
authors.lastname: Graça
authors.forename: F
authors.initials: F
authors.lastname: Ramalho
authors.forename: A
authors.initials: A
authors.lastname: Costa
authors.forename: A
authors.initials: A
authors.lastname: Batista
authors.forename: M C
authors.initials: MC
authors.lastname: De Moura
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy / Q000473:pathology*; D002761:Cholangitis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged