Granulocyte transfusion in the management of fulminant invasive fungal rhinosinusitis.
Usually, fulminant, invasive fungal rhinosinusitis is observed in the immunocompromised patient and is associated with significant morbidty, and mortality. A high index of suspicion and early diagnosis is imperative for optimizing outcome. Mainstays of treatment include antifungal agents and radical resection of necrotic tissue. Reversal of the underlying medical condition, when possible, is a critical part of the management. In the neutropenic population, granulocyte transfusion may represent an adjunct to current therapy. We provide the first report of a case of invasive fungal rhinosinusitis in which this intervention was used.
Samadi
D S
DS
Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, USA.
Goldberg
A N
AN
Orlandi
R R
RR
D000368:Aged; D001228:Aspergillosis / Q000628:therapy*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D017708:Leukocyte Transfusion / Q000379:methods*; D009503:Neutropenia / Q000209:etiology / Q000628:therapy*; D009504:Neutrophils; D012220:Rhinitis / Q000628:therapy*; D012852:Sinusitis / Q000276:immunology / Q000628:therapy*