The suppressive effect of mangiferin with exercise on blood lipids in type 2 diabetes.
The effect of mangiferin (MF) with exercise on bood lipids was studied in KK-Ay mice, an animal model of type 2 diabetes. MF (30 mg/kg) reduced the blood cholesterol (p<0.05) and triglyceride level (p<0.01) of KK-Ay mice with exercise 2 weeks after oral administration when compared with the control group. Diabetes also often has elevated lipid levels. Therefore, it may be that MF has beneficial effects on hyperlipidemia in type 2 diabetes.
Miura
T
T
Department of Clinical Nutrition, Suzuka University of Medical Science, Mie, Japan. miura@suzuka-u.ac.jp
Iwamoto
N
N
Kato
M
M
Ichiki
H
H
Kubo
M
M
Komatsu
Y
Y
Ishida
T
T
Okada
M
M
Tanigawa
K
K
D000818:Animals; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D005082:Physical Exertion / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D014280:Triglycerides; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin; D002784:Cholesterol