Arterial distensibility as a possible compensatory mechanism in chronic aortic insufficiency.
OBJECTIVE
To evaluate elastic properties of conduit arteries in asymptomatic patients who have severe chronic aortic regurgitation.


METHODS
Twelve healthy volunteers aged 30+/-1 years (control group) and 14 asymptomatic patients with severe aortic regurgitation aged 29+/-2 years and left ventricular ejection fraction of 0.61+/-0.02 (radioisotope ventriculography) were studied. High-resolution ultrasonography was performed to measure the systolic and diastolic diameters of the common carotid artery. Simultaneous measurement of blood pressure enabled the calculation of arterial compliance and distensibility.


RESULTS
No differences were observed between patients with aortic regurgitation and the control group concerning age, sex, body surface, and mean blood pressure. Pulse pressure was significantly higher in the aortic regurgitation group compared with that in the control group (78+/-3 versus 48+/-1mmHg, P<0.01). Arterial compliance and distensibility were significantly greater in the aortic regurgitation group compared with that in the control group (11.0+/-0.8 versus 8.1+/-0.7 10(-10) N-1 m4, P=0.01 e and 39.3+/-2.6 versus 31.1+/-2.0 10(-6) N-1 m2, P=0.02, respectively).


CONCLUSIONS
Patients with chronic aortic regurgitation have increased arterial distensibility. Greater vascular compliance, to lessen the impact of systolic volume ejected into conduit arteries, represents a compensatory mechanism in left ventricular and arterial system coupling.
Kopel
L
L
Heart Institute, Clínicas Hospital, FM, University of São Paulo, Brazil.
Tarasoutchi
F
F
Medeiros
C
C
Carvalho
R T
RT
Grinberg
M
M
Lage
S G
SG
D000328:Adult; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001158:Arteries / Q000000981:diagnostic imaging / Q000502:physiology*; D016022:Case-Control Studies; D002908:Chronic Disease; D004548:Elasticity; D005260:Female; D006801:Humans; D008297:Male; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology*