Synthesis of novel D- and L-3'-deoxy-3'-C-hydroxymethyl nucleoside with exocyclic methylene as potential ribonucleotide reductase inhibitor.
D- and L-3'-Deoxy-3'-C-hydroxymethyl thymidine substituted with exocyclic methylene at 2'-position were synthesized, starting from D- and L-xylose as potential ribonucleotide reductase inhibitor, respectively, but they were found to be inactive against several tumor cell lines.
Chun
M W
MW
College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
Kim
M J
MJ
Jo
U H
UH
Kim
J H
JH
Kim
H D
HD
Jeong
L S
LS
D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006838:Hydrocarbons; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*; D013936:Thymidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014994:Xylose / Q000737:chemistry
D004791:Enzyme Inhibitors; D006838:Hydrocarbons; C030011:carbene; D014994:Xylose; D012264:Ribonucleotide Reductases; D008697:Methane; D013936:Thymidine