Murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is a determinant of dissemination that increases inflammation at initial sites of infection.
The murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is an important determinant of dissemination during primary infection. Reduced peak levels of viremia at day 5 were followed by reduced levels of virus in salivary glands starting at day 7 when mck insertion (RM461) and point (RM4511) mutants were compared to mck-expressing viruses. A dramatic MCK-2-enhanced inflammation occurred at the inoculation site over the first few days of infection, preceding viremia. The data further reinforce the role of MCK-2 as a proinflammatory signal that recruits leukocytes to increase the efficiency of viral dissemination in the host.
Saederup
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Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124, USA.
Aguirre
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SA
Sparer
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Bouley
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DM
Mocarski
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ES
D000818:Animals; D019742:Chemokines, CC / Q000235:genetics / Q000502:physiology*; D006566:Herpesviridae Infections / Q000473:pathology / Q000821:virology*; D006614:Hindlimb; D051379:Mice; D008807:Mice, Inbred BALB C; D018146:Muromegalovirus / Q000276:immunology; D016254:Mutagenesis, Insertional; D017354:Point Mutation; D012469:Salivary Glands / Q000821:virology; D014764:Viral Proteins; D014766:Viremia
D019742:Chemokines, CC; C121663:MCK-2 protein, Mouse cytomegalovirus 1; D014764:Viral Proteins