title: [Invasive infection caused Streptococcus group A and streptococcal toxic shock syndrome].
abstract: Modern data on the etiology and pathogenesis of invasive streptococcal infection and the syndrome of streptococcal toxic shock are presented. In the course of the last 10-15 years essential changes in the system of interaction of group A streptococci and the macroorganism have been noted. The growth of morbidity in severe invasive forms of streptococcal infection with different clinical manifestations, including the syndrome of toxic shock, is observed. Most often this disease develops in elderly people, making up a group of risk, but sometimes affects healthy young people. Different pathogenicity factors of streptococci, capable of inducing the development of infection, are analyzed. Special attention is given to superantigens: pyrogenic toxins and M-protein. The suggestion that the development of the disease is seemingly linked with the state of specific protective immunity is substantiated. In spite of achievements in the field of the microbiology and immunology of group A streptococci, the causes of the appearance and development of invasive streptococcal infection have not yet been determined.
authors.affiliation: Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Danilova
mesh_terms: D006801:Humans; D012772:Shock, Septic / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology*; D013290:Streptococcal Infections / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology*; D013297:Streptococcus pyogenes / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity; D013577:Syndrome