title: Selective, orally active MMP inhibitors with an aryl backbone.
abstract: This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13.
authors.affiliation: Pharmacia, Department of Medicinal Chemistry, 4901 Searle Parkway, Skokie, IL 60077, USA. barta@netmug.org
authors.forename: T E
authors.initials: TE
authors.lastname: Barta
authors.forename: D P
authors.initials: DP
authors.lastname: Becker
authors.forename: L J
authors.initials: LJ
authors.lastname: Bedell
authors.forename: G A
authors.initials: GA
authors.lastname: De Crescenzo
authors.forename: J J
authors.initials: JJ
authors.lastname: McDonald
authors.forename: P
authors.initials: P
authors.lastname: Mehta
authors.forename: G E
authors.initials: GE
authors.lastname: Munie
authors.forename: C I
authors.initials: CI
authors.lastname: Villamil
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D015195:Drug Design; D053509:Matrix Metalloproteinase 13; D061965:Matrix Metalloproteinase Inhibitors; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D010880:Piperidines; D011480:Protease Inhibitors; D013438:Sulfhydryl Compounds; D053509:Matrix Metalloproteinase 13; C507083:Mmp13 protein, rat