title: Substance P: a new era, a new role.
abstract: Substance P has been extensively studied and is considered the prototypic neuropeptide of the more than 50 known neuroactive molecules. The understanding of substance P has evolved beyond the original concept as the pain transmitter of the dorsal horn. Animal and genetic research, recent developments of nonpeptide substance P antagonists, and important changes in the understanding of neurotransmission have each contributed to the current understanding of substance P After 7 decades, the physiologic role of substance P is known as a modulator of nociception, involved in signaling the intensity of noxious or aversive stimuli. Genetic studies in mice and development of substance P antagonists provide more recent results that support the redefinition of the central role of substance P Evidence suggests that this neuropeptide is an integral part of central nervous system pathways involved in psychologic stress.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, USA. devaneL@musc.edu
authors.forename: C L
authors.initials: CL
authors.lastname: DeVane
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D000077608:Aprepitant; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D009025:Morpholines / Q000494:pharmacology / Q000627:therapeutic use; D009479:Neuropeptides / Q000037:antagonists & inhibitors / Q000502:physiology*; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D013315:Stress, Psychological / Q000503:physiopathology; D013373:Substance P / Q000037:antagonists & inhibitors / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D018687:Antidepressive Agents, Second-Generation; D009025:Morpholines; D009479:Neuropeptides; D000077608:Aprepitant; D013373:Substance P