title: [Chronic intestinal pseudo-obstruction. Clinical symptomatology and course].
abstract: OBJECTIVE
  Chronic intestinal pseudoobstruction (CIP) is a motility disorder clinically characterized by recurrent symptoms of small intestinal or large bowel obstruction without organic stenosis. The aim of the present study was to assess the clinical presentation and course of the disease.
  
  
  METHODS
  During a four year period all available data including the symptoms as assessed by the bowel disease questionnaire (BDQ) of all patients with newly established diagnosis of CIP were analyzed including duration of symptoms and previous surgical interventions due to the abdominal symptoms.
  
  
  RESULTS
  Data of nine patients (five females, four males, age 20 - 64 years) with newly diagnosed CIP were available for analysis. Median age at initial onset of symptoms were 24 years. The final diagnosis of CIP was established after a median of 7 years (range 1 - 20). Initially, the majority of patients suffered from uncharacteristic symptoms such as abdominal fullness and abdominal pain. All patients had undergone repeated abdominal surgical interventions for suspected mechanical bowel obstruction. On average, the first surgical intervention was performed 5 years after the onset of symptoms and there was a median number of 10 treatments as in-patients. Suspected acute bowel obstruction occurred between 1 and 14 times and laparotomies were performed in 50 % of these events.
  
  
  CONCLUSIONS
  The diagnosis of CIP is usually preceded by several years with uncharacteristic abdominal symptoms. During this time, most patients undergo multiple surgical interventions. Thus, in patients with repeated suspected acute bowel obstruction without definite proof of mechanical obstruction, CIP has to be taken into consideration as differential diagnosis. In this context, small bowel manometry is an important diagnostic tool.
authors.affiliation: Abteilung für Gastroenterologie und Hepatologie (Direktor: Prof. Dr. G. Gerken), Zentrum für Innere Medizin.
authors.forename: J M
authors.initials: JM
authors.lastname: Gschossmann
authors.forename: G
authors.initials: G
authors.lastname: Holtmann
authors.forename: L
authors.initials: L
authors.lastname: Bünger
authors.forename: D
authors.initials: D
authors.lastname: Grandt
authors.forename: K
authors.initials: K
authors.lastname: Drochner
authors.forename: G
authors.initials: G
authors.lastname: Gerken
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D002908:Chronic Disease; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged