title: Inhibitory effects of KN-93, an inhibitor of Ca2+ calmodulin-dependent protein kinase II, on light-regulated root gravitropism in maize.
abstract: Light is essential for root gravitropism in Zea mays L., cultivar Merit.  It is hypothesized that calcium mediates this light-regulated response.  KN-93, an inhibitor of calcium/calmodulin kinase II (CaMK II), inhibits light-regulated root gravitropism but does not affect light perception.  We hypothesize that CaMK II, or a homologue, operates late in the light/gravity signal transduction chain.  Here we provide evidence suggesting a possible physiological involvement of CaMK II in root gravitropism in plants.
authors.affiliation: Department of Plant Biology, University of California at Berkeley, USA.
authors.lastname: Lu Y-T
authors.forename: L J
authors.initials: LJ
authors.lastname: Feldman
authors.forename: H
authors.initials: H
authors.lastname: Hidaka
mesh_terms: D001596:Benzylamines / Q000378:metabolism / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D004791:Enzyme Inhibitors; D018522:Gravitropism / Q000187:drug effects / Q000502:physiology*; D008027:Light; D010766:Phosphorylation; D018524:Phototropism / Q000187:drug effects / Q000502:physiology; D010940:Plant Proteins / Q000032:analysis / Q000378:metabolism; D018518:Plant Root Cap / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D018517:Plant Roots / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013449:Sulfonamides / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors; D003313:Zea mays / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D000096926:Benzenesulfonamides
chemical_list: D001596:Benzylamines; D002118:Calcium; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D004791:Enzyme Inhibitors; D010940:Plant Proteins; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D013449:Sulfonamides; C072105:KN 93; D000096926:Benzenesulfonamides