[Effect of antibacterial therapy on the epidemic threat of experimental pneumonic plague in monkeys].
High therapeutic efficacy of aminoglycosides, quinolones, cephalosporins and rifampicins was demonstrated in experiments performed on monkeys, infected aerogenically by Yersinia pestis 1300. Antibacterials inhibited Y. pestis cells reproduction in the infected animals organisms evaluated by dynamics of bacterial cells isolated from the blood and fauces of the animals. It was shown that antibacterial therapy prevented infection transmission from the infected animals. The time of respiratory tract sanitation was in the range from 12 to 48 hours after the treatment and depended on drug efficacy.
Romanov
V E
VE
Research Institute on Microbiology, Ministry of Defense of Russian Federation, Kirov.
Vasil'ev
N T
NT
Shabalin
B A
BA
Mironin
A V
AV
D000397:Air Pollution; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004196:Disease Outbreaks; D009055:Mouth / Q000382:microbiology; D010215:Papio; D010930:Plague / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D015010:Yersinia pestis / Q000187:drug effects
D000900:Anti-Bacterial Agents