Large-scale manufacturing of all four 2'-deoxynucleosides via novel strategies including a chemo-enzymatic process.
A chemical synthesis of 2-deoxyribose-1-phosphate 2 and its enzymatic conversion into purine 2'-deoxynucleosides (dNus) are shown. Besides the chemo-enzymatic process for purine dNus, a modified process for practical dC preparation is also established. Consequently, a series of practical manufacturing processes of all four dNus have been realized via novel strategies.
Komatsu
H
H
Chemical Synthesis Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba 297-0017, Japan.
Awano
H
H
Tanikawa
H
H
Itou
K
K
Ikeda
I
I
D011684:Purine Nucleosides / Q000138:chemical synthesis*; D011683:Purine-Nucleoside Phosphorylase / Q000737:chemistry*; D012267:Ribosemonophosphates / Q000138:chemical synthesis / Q000737:chemistry*
D011684:Purine Nucleosides; D012267:Ribosemonophosphates; C031302:2-deoxyribose 1-phosphate; D011683:Purine-Nucleoside Phosphorylase