Novel lipophilic chloroquine analogues for a highly efficient gene transfer into gynecological tumors.
Liposomal vectors based on cationic lipids have been proven to be an attractive alternative to viral vectors in gene therapy protocols with regard to safety and manufacturing concerns. In order to improve the transfection efficiency we have synthesized two novel carboxycholesteryl-modified chloroquine analogues. Due to their potential endosomal buffering capacity these compounds enable the efficient transfection of various gynecological tumors and therefore are promising reagents in gene therapy applications.
Keil
O
O
Institute of Chemical Oncology, Heinrich Heine University of Duesseldorf, Universitaetsstr. 1, D-40001 Duesseldorf, Germany. keil@got-therapeutics.de
Bojar
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Prisack
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Dall
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D002470:Cell Survival / Q000187:drug effects; D002738:Chloroquine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology; D005260:Female; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005833:Genital Neoplasms, Female / Q000628:therapy; D006801:Humans; D008081:Liposomes; D014162:Transfection / Q000379:methods*; D014407:Tumor Cells, Cultured
D008081:Liposomes; D002738:Chloroquine