title: [Comparative study of the diagnostic value of new cholera eltor bacteriophages ctx+, ctx-, and KhDF-3, 4, and 5].
abstract: The comparative evaluation of the diagnostic value of new cholera eltor bacteriophages ctx+ and ctx-, as well as monophages X[symbol: see text]-3, 4, 5, demonstrated their high activity and specificity. Using of these bacteriophages epidemic potential of 95% Vibrio cholerae eltor strains ctx+ and 84.5% of V. cholerae eltor stains ctx- was determined. Commercial monophages X[symbol: see text]-3, 4, 5 were inferior to bacteriophages ctx+ and ctx- in their diagnostic value: only 55% of strains having gene ctxAB were found to be epidemically dangerous, i.e. 45% of strains capable of causing the disease were not detected. On the basis of the results obtained in this investigation cholera eltor bacteriophages ctx+ and ctx- were recommended for introduction into practical use, while further production of cholera diagnostic monophages X[symbol: see text]-3, 4, 5 was recommended to be stopped.
authors.affiliation: Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations, Moscow, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Saiapina
authors.forename: T I
authors.initials: TI
authors.lastname: Anisimova
authors.forename: G V
authors.initials: GV
authors.lastname: Adamova
authors.forename: I V
authors.initials: IV
authors.lastname: Kasina
authors.forename: N M
authors.initials: NM
authors.lastname: Ostroumova
authors.forename: I V
authors.initials: IV
authors.lastname: Gracheva
authors.forename: E S
authors.initials: ES
authors.lastname: Kazakova
authors.forename: L F
authors.initials: LF
authors.lastname: Livanova
authors.forename: N P
authors.initials: NP
authors.lastname: Mironova
authors.forename: T A
authors.initials: TA
authors.lastname: Kudriakova
authors.forename: B A
authors.initials: BA
authors.lastname: Batyrova
authors.forename: K B
authors.initials: KB
authors.lastname: Omarova
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Reznikov
authors.forename: O P
authors.initials: OP
authors.lastname: Plotnikov
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Shchelkanova
authors.forename: A N
authors.initials: AN
authors.lastname: Malakhaeva
authors.forename: G I
authors.initials: GI
authors.lastname: Korovkina
authors.forename: N I
authors.initials: NI
authors.lastname: Smirnova
authors.forename: A K
authors.initials: AK
authors.lastname: Noskov
authors.forename: E A
authors.initials: EA
authors.lastname: Bushineva
mesh_terms: D001434:Bacteriophage Typing / Q000379:methods; D012680:Sensitivity and Specificity; D014734:Vibrio cholerae / Q000145:classification* / Q000472:pathogenicity