title: Constrained flexibility in PNA: DNA binding studies with bridged aminopropylglycyl PNA.
abstract: Introduction of methylene bridges in aegPNA and apgPNA molecules give rise to cyclic five and six membered ring structures. Synthesis of a new six membered cyclic PNA monomer, aminopipecolyl PNA (pipPNA) is reported. Incorporation of pipPNA into PNA oligomers and comparative binding with target DNA sequences is studied.
authors.affiliation: Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India.
authors.forename: P S
authors.initials: PS
authors.lastname: Lonkar
authors.forename: V A
authors.initials: VA
authors.lastname: Kumar
authors.forename: K N
authors.initials: KN
authors.lastname: Ganesh
mesh_terms: D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D020135:Peptide Nucleic Acids; D004247:DNA