The quantification of wound healing as a method to assess late radiation damage in primate skin exposed to high-energy protons.
In an experiment examining the effects of space radiations on primates, different groups of rhesus monkeys (Macaca mulatta) were exposed to single whole-body doses of 32- or 55-MeV protons.  Survivors of those exposures, together with age-matched controls, have been monitored continuously since 1964 and 1965.  Late effects of nominal proton doses ranging from 2-6 Gray have been measured in vitro using skin fibroblasts from the animals.  A logical extension of that study is reported here, and it involves observations of wound healing after 3-mm diameter dermal punches were removed from the ears (pinnae) of control and irradiated monkeys.  Tendencies in the reduction of competence to repair cutaneous wounds have been revealed by the initial examinations of animals that received doses greater than 2 Gy more than 2 decades earlier.  These trends indicate that this method of assessing radiation damage to skin exposed to high-energy radiations warrants further study.
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USAF School of Aerospace Medicine, Brooks Air Force Base, TX 78235-5301.
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D000818:Animals; D001706:Biopsy / Q000379:methods; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005347:Fibroblasts / Q000473:pathology / Q000528:radiation effects; D008253:Macaca mulatta; D008297:Male; D011522:Protons / Q000009:adverse effects*; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D012867:Skin / Q000473:pathology* / Q000528:radiation effects*; D013026:Space Flight; D014945:Wound Healing / Q000502:physiology / Q000528:radiation effects*
D011522:Protons