Recurrent CA1 collateral axons in developing rat hippocampus.
Rat perinatal (E20-P0) CA1 pyramidal neurons were either synaptically active or silent. We show here that, during this developmental period, active but not silent cells form recurrent axon-collaterals that invade the radiatum and the lacunosum moleculare strata. These recurrents were never observed in adult rats. We propose that these transient recurrent axons may participate in the activity-dependent modulation of the synaptogenesis
Aniksztejn
L
L
INMED-INSERM U29, Parc scientifique et technologique de Luminy, 163 Route de Luminy BP 13, 13008 Cedex, Marseille, France.
Demarque
M
M
Morozov
Y
Y
Ben-Ari
Y
Y
Represa
A
A
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure*; D002454:Cell Differentiation / Q000502:physiology*; D048429:Cell Size / Q000502:physiology; D003712:Dendrites / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D004558:Electric Stimulation; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005333:Fetus; D018756:GABA Antagonists / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D007150:Immunohistochemistry; D008239:Lysine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009415:Nerve Net / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D017966:Pyramidal Cells / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D018756:GABA Antagonists; D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate; C013411:biocytin; D008239:Lysine