title: Ten days of head down tilt: effects of isotonic and hypertonic saline loads in normal man.
abstract: The initial response to bed rest involves an increase in central blood volume leading to a an enhanced renal excretion of fluid and electrolytes. Within 24 hours of head-down bed rest a new steady state condition occurs with a sustained reduction of plasma volume, extracellular fluid volume, total body water, and body weight. It was the purpose of the present study to elucidate the volume homeostatic mechanisms during head-down bed rest by investigating the endocrine and renal responses to a load of sodium chloride given as either an isotonic or a hypertonic solution.
authors.affiliation: Department of Medical Physiology, University of Copenhagen, Denmark.
authors.forename: M H
authors.initials: MH
authors.lastname: Bestle
authors.forename: H
authors.initials: H
authors.lastname: Jacobsen
authors.forename: P
authors.initials: P
authors.lastname: Norsk
authors.forename: P
authors.initials: P
authors.lastname: Bie
mesh_terms: D000804:Angiotensin II / Q000097:blood / Q000187:drug effects / Q000378:metabolism*; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000187:drug effects / Q000378:metabolism*; D001510:Bed Rest; D018475:Head-Down Tilt; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007552:Isotonic Solutions; D008297:Male; D009994:Osmolar Concentration; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000494:pharmacology; D016683:Supine Position
chemical_list: D007552:Isotonic Solutions; D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D001127:Arginine Vasopressin; D012965:Sodium Chloride; D009320:Atrial Natriuretic Factor