[Changes of cardiac function during +Gz exposure in rabbits].
Changes of cardiac function was studied during +Gz exposure in rabbits. Seven New Zealand rabbits were anesthetized and exposed to +2, +4, and +6 Gz (each for 30s, onset rate 1G/s, with 15 min interval in between). The left ventricular systolic pressure (LVSP), peak rate of left ventricular pressure rising (+dp/dtmax) and ECG were recorded. The results showed that during +2, +4 and +6 Gz exposures, LVSP decreased by 62.96% (P<0.01), 63.34% (P<0.01) and 82.01% (P<0.01) respectively, and +dp/dtmax decreased by 58.46% (P<0.01), 53.59% (P<0.01) and 63.06% (P<0.01) respectively, and the left ventricular end diastolic pressure decreased by 67.78 % (P>0.05), 332.74 % (P<0.01) and 500.54% (P<0.01) respectively, as compared with those of control. It is suggested that cardiac function is depressed with +Gz exposure.
Sun
X
X
Department of Aerospace Biodynamics, Fourth Military Medical University, Xi'an, China.
Cai
J
J
Liu
Y
Y
Xue
L
L
Sun
H
H
D000054:Acceleration / Q000009:adverse effects; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004562:Electrocardiography; D006339:Heart Rate / Q000502:physiology; D018471:Hypergravity / Q000009:adverse effects*; D010100:Oxygen / Q000097:blood; D011817:Rabbits; D016277:Ventricular Function, Left / Q000502:physiology*; D017725:Ventricular Pressure / Q000502:physiology*
D002245:Carbon Dioxide; D010100:Oxygen