Antenatal diagnosis of Multicystic Renal Dysplasia.
Multicystic Renal Dysplasia (MRD) was discovered during antenatal ultrasound examination in 138 fetuses between 1980 and 1995. Associated malformations were present in 66 % (42 % urological) and 22 % of the fetuses did not survive the pregnancy or the peri-natal period.Anatomical analysis showed a wider variety of MRD than in classical descriptions. Obstruction of the urinary tract was almost invariable. Like the hypothesis published by Beck in 1971, our view is that, with a very early obstruction of the urinary tract (during the first trimester), there is a dysplastic evolution of renal tissue, while later in pregnancy the same obstruction can induce a hydronephrosis with corticomedullary dysplasia.We advise complete neonatal urological investigation, and surgical removal of multicystic kidneys, to avoid multiple and inadequate evaluations of those children with a single functioning renal unit.
Ranke
A
A
Service de Chirurgie Pédiatrique B, Hôpital d'Enfants, Vandoeuvre-les-Nancy, France.
Schmitt
M
M
Didier
F
F
Droulle
P
P
D005260:Female; D005313:Fetal Death; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D021782:Multicystic Dysplastic Kidney / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000601:surgery; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D015996:Survival Rate; D014463:Ultrasonography