title: Interleukin-12 and interleukin-18 are indispensable for protective immunity against enteropathogenic Yersinia.
abstract: Previous results have demonstrated an essential role of gamma interferon (IFN-gamma) in resistance against Yersinia enterocolitica. Hence, we investigated the course of Yersinia infection in mice deficient for the IFN-gamma-inducing cytokines interleukin-12 (IL-12 p40(-/-)) or interleukin-18 (IL-18(-/-)). The experiments described herein argue for a critical role of both cytokines in protective immune responses against this pathogen.
authors.affiliation: Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität, Pettenkoferstrasse 9a, München, D-80336, Germany. joachim.hein@mikrobio.med.uni-erlagen.de
authors.forename: J
authors.initials: J
authors.lastname: Hein
authors.forename: A
authors.initials: A
authors.lastname: Sing
authors.forename: M S
authors.initials: MS
authors.lastname: Di Genaro
authors.forename: I B
authors.initials: IB
authors.lastname: Autenrieth
mesh_terms: D000818:Animals; D005260:Female; D007371:Interferon-gamma / Q000502:physiology; D018664:Interleukin-12 / Q000502:physiology*; D020382:Interleukin-18 / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica
chemical_list: D020382:Interleukin-18; D018664:Interleukin-12; D007371:Interferon-gamma