Synthesis and biophysical studies of oligonucleotides containing hydroxamate linkages.
Novel thymidine dimers containing hydroxamate linkages were synthesized, incorporated into oligonucleotide sequences and studied their hybridization properties against complementary DNA and RNA targets.
Ramasamy
K S
KS
Medicinal Chemistry Division, ICN Pharmaceuticals, Inc., 3300 Hyland Avenue, Costa Mesa, California 92626, USA.
Stoisavljevic
V
V
Lau
J Y
JY
D004247:DNA / Q000737:chemistry; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D011740:Pyrimidine Dimers / Q000138:chemical synthesis / Q000737:chemistry; D011742:Pyrimidine Nucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D013936:Thymidine / Q000031:analogs & derivatives
D006877:Hydroxamic Acids; D009841:Oligonucleotides; D011740:Pyrimidine Dimers; D011742:Pyrimidine Nucleotides; D012313:RNA; D004247:DNA; D013936:Thymidine