[Celiac disease in adolescents and young adults. A challenge for gastroenterologists of children and adults].
BACKGROUND
Follow-up of celiac patients in Chile is often interrupted when adolescents are referred to adult gastroenterologists.


OBJECTIVE
To study the evolution of patients with celiac disease when they reach adolescence or young adulthood.


METHODS
Current adherence to gluten-free diet and its relation to symptoms and circulating antiendomysial antibodies were evaluated in the 58 confirmed celiac patients older than 12 years of age controlled at 3 hospitals in Santiago.


RESULTS
Mean age at the moment of this assessment was 17.8 +/- 5 years, 65.5% were women, 12.5% were at nutritional risk (-IDS) while 20% were overweight/obese. Although all patients declared themselves asymptomatic, a focused questionnaire revealed that 26% suffered some symptoms. Only 24.1% followed a strict gluten-free diet. Eight of 20 patients who ate gluten-containing diets had negative antiendomysial antibodies (EMA), three of whom turned positive within 6 to 9 months. In three of four (asymptomatic) cases that accepted a new jejunal biopsy, histology was abnormal. One patient who followed a strict diet had EMA (+) and normal histology.


CONCLUSIONS
These results confirm that after childhood, symptoms abate significantly in celiac patients. The observed sensitivity and specificity of EMA makes necessary to maintain small intestinal biopsies as the gold standard for diagnosis and confirmation of the disease.
Roessler
J L
JL
Hospitales Félix Bulnes, Exequiel González Cortés, San Juan de Dios, Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile. joserb@vtr.net
Ríos
G
G
Alarcón
T
T
Bergenfreid
C
C
Mondragón
A
A
Araya
M
M
D000293:Adolescent; D000328:Adult; D001294:Attitude to Health; D001323:Autoantibodies / Q000032:analysis; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002446:Celiac Disease / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D002677:Chile; D004032:Diet; D005260:Female; D005500:Follow-Up Studies; D005762:Gastroenterology; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity
D001323:Autoantibodies