Biotransformation of 1,8-cineole by human liver microsomes.
The biotransformation of 1,8-cineole has been investigated by using human liver microsomes. A single oxidized metabolite, 2-exo-hydroxy-1,8-cineole, was isolated. Its formation was investigated under various conditions by changing incubation time, P450 level in liver microsomes, and substrate concentration.
Miyazawa
M
M
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka, Osaka 577-8502, Japan.
Shindo
M
M
D001711:Biotransformation; D002849:Chromatography, Gas; D003511:Cyclohexanols / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D000077591:Eucalyptol; D006801:Humans; D006900:Hydroxylation; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D039821:Monoterpenes; D013379:Substrate Specificity; D013729:Terpenes / Q000493:pharmacokinetics*
D003511:Cyclohexanols; D039821:Monoterpenes; D013729:Terpenes; D003577:Cytochrome P-450 Enzyme System; D000077591:Eucalyptol