Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results.
A new therapy for severe ischemic heart disease has been developed; therapeutic angiogenesis induced by the local implantation of autologous bone marrow cells (BMC). After confirming that no detrimental changes were induced by this treatment in a canine heart model, a clinical trial was commenced in 1999. Thus far, 5 patients have been given this new treatment concomitant with coronary artery bypass grafting and all have been followed up for at least 1 year. Autologous BMC were implanted into the ungraftable area and postoperative cardiac scintigraphy showed specific improvement in coronary perfusion in 3 of the 5 patients. Postoperative chest radiography, electrocardiography, echocardiography and blood tests did not reveal any detrimental changes. In conclusion, this new therapy appears to be safe and could provide a treatment option for patients with otherwise untreatable ischemic heart disease.
Hamano
K
K
First Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan. kimikazu@po.cc.yamaguchi-u.ac.jp
Nishida
M
M
Hirata
K
K
Mikamo
A
A
Li
T S
TS
Harada
M
M
Miura
T
T
Matsuzaki
M
M
Esato
K
K
D000368:Aged; D016026:Bone Marrow Transplantation / Q000379:methods*; D001026:Coronary Artery Bypass; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D018919:Neovascularization, Physiologic; D011877:Radionuclide Imaging; D014182:Transplantation, Autologous; D016896:Treatment Outcome