[The interaction of the rad201 gene with mei-9 and mei-41 genes in germline cells of Drosophila female].
The effect of Drosophila mutation rad201G1 together with mutations mei-41D5 and mei-9a on the sensitivity of oocytes to induction of dominant lethals (DLs) was studied. To this end, the frequencies of spontaneous and gamma-radiation-induced DLs in consecutive egg batches of females carrying double or single mutations were estimated. Since the effects of the mutations examined are expressed only at the previtellogenetic stages of oogenesis, only newly hatched (0-5-hour-old) females, whose oocytes did not develop farther than stage 7, were irradiated. The results obtained indicated that in intact and irradiated oocytes of double mutants mei-9a rad201G1 and mei-41D5 rad201G1, mutation rad201G1 epistatically suppresses the mutations of the both mei genes.
Sarantseva
S V
SV
St. Petersburg Konstantinov Institute of Nuclear Physics, Gatchina, Leningrad Oblast, 188350 Russia.
Khromykh
Iu M
IuM
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000528:radiation effects; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000235:genetics* / Q000528:radiation effects; D029721:Drosophila Proteins / Q000235:genetics* / Q000528:radiation effects; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000528:radiation effects; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics* / Q000528:radiation effects; D009154:Mutation / Q000528:radiation effects; D009687:Nuclear Proteins; D009865:Oocytes / Q000502:physiology / Q000528:radiation effects; D017346:Protein Serine-Threonine Kinases; D014466:Ultraviolet Rays
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; C097527:MEI-9 protein, Drosophila; D009687:Nuclear Proteins; C444435:Mei-41 protein, Drosophila; D017346:Protein Serine-Threonine Kinases