Clonal chromosome rearrangements in hairy cell leukemia: personal experience and review of literature.
Cytogenetic studies in hairy cell leukemia (HCL) are rare. In the present report, cytogenetic investigations were performed on marrow cells obtained from 21 HCL male patients with a mean age of 57 years and active disease. Karyotypic analysis was successful in 18 of the 21 patients, either at diagnosis or in relapse after treatment with IFNa. Clonal chromosome abnormalities were detected in eight of 18 cases. The chromosome most frequently involved in the rearranged karyotypes was chromosome 14. Results are discussed with respect to 79 abnormal HCL cases obtained from an extensive review of the literature from 1978 to 2000.
Sambani
C
C
Laboratory of Health Physics & Environmental Hygiene, I/NT-RP, NCSR "Demokritos," 153 10 Aghia Paraskevi, Athens, Greece. csambani@mail.demokritos.gr
Trafalis
D T
DT
Mitsoulis-Mentzikoff
C
C
Poulakidas
E
E
Makropoulos
V
V
Pantelias
G E
GE
Mecucci
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002877:Chromosomes, Human / Q000235:genetics; D002999:Clone Cells; D005434:Flow Cytometry; D006801:Humans; D007621:Karyotyping; D007943:Leukemia, Hairy Cell / Q000235:genetics*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008875:Middle Aged
D008070:Lipopolysaccharides