5-hydroxytryptamine and the gastrointestinal migrating motor complex.
The migrating motor complex (MMC) is the basic cyclic pattern of gastrointestinal motility that is observed in the interdigestive periods in humans as well as in monogastric animals. Among the mediators involved in its regulation, an increasing number of reports point out that 5-hydroxytryptamine (5-HT) has a pivotal role. Taking into account that this pattern is disturbed in patients suffering from several gastrointestinal disorders, studies leading to a better understanding of 5-HT actions have special relevance. This article reviews the current knowledge on the role of 5-HT receptors in the control of the MMC.
Plaza
M A
MA
Department of Pharmacology and Physiology, Veterinary Faculty, Zaragoza, Spain. aplaza@posta.unizar.es
D000818:Animals; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006801:Humans; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D012701:Serotonin