[Preventive effect of carotene-containing preparations in acute gastritis model].
A preliminary course of treatment with cascatol and beta-clamin, original drugs of natural origin, prevented the butadion damage of mucous membrane of the stomach in experimental rats. An analysis of the morphometric data of histologic samples taken from the test animals showed the effect to be dose-dependent. A 40-day treatment with cascatol and beta-clamin in a single daily dose of 0.05 mg/kg produced a gastroprotector effect, while the same drugs in a dose of 0.5 mg/kg offered no protection for the stomach against the butadion damage.
Buiuklinskaia
O V
OV
Department of Pharmacology, Department of Pathologic Anatomy, Archangelsk State Medical Academy, Troitskii pr. 51, Archangelsk 163051 Russia.
Khodasevich
L S
LS
Krylov
I A
IA
D000208:Acute Disease; D000464:Alginates / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001205:Ascorbic Acid / Q000627:therapeutic use; D004338:Drug Combinations; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D010653:Phenylbutazone; D051381:Rats; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*; D019207:beta Carotene / Q000627:therapeutic use*
D000464:Alginates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D006603:Hexuronic Acids; D019207:beta Carotene; D014810:Vitamin E; D020723:Glucuronic Acid; D010653:Phenylbutazone; D024502:alpha-Tocopherol; D001205:Ascorbic Acid; D024505:Tocopherols