Synthesis and terminal functionalization of a polymerizable phosphatidylethanolamine.
We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such as biotin or N-(epsilon-maleimidocaproyl (EMC), to facilitate bioconjugation reactions. The lipid conjugate can be used to generate a multifunctional substrate-supported phospholipid film that is further stabilized via in-situ photocopolymerization.
Sun
X L
XL
Laboratory for Biomolecular Materials Research, Department of Surgery and Bioengineering, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Liu
H
H
Orban
J M
JM
Sun
L
L
Chaikof
E L
EL
D000179:Acrylates / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry; D003432:Cross-Linking Reagents; D015195:Drug Design; D008567:Membranes, Artificial; D008863:Microspheres; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
D000179:Acrylates; D000180:Acrylic Resins; D003432:Cross-Linking Reagents; D008567:Membranes, Artificial; D010714:Phosphatidylethanolamines; D011108:Polymers; C006903:carbopol 940