Direct comparison of the potency of three novel cAMP analogs to induce CREB-phophorylation in rat pinealocytes.
A modified analog of cyclic adenosine 3',5'-monophosphate (cAMP), Sp-adenosine-3',5'-monophosphorothioate, designed to be highly membrane-permeable and resistant towards phosphodiesterases was found to induce the phosphorylation of the cAMP-regulated transcription factor cyclic AMP-responsive element binding protein in cultured rat pinealocytes more efficiently than previously described cAMP analogs.
Maronde
E
E
Dr. Senckenbergische Anatomie, Anatomisches Institut II, J.W. Goethe Universität, Frankfurt, Germany. emaronde@web.de
Korf
H W
HW
Niemann
P
P
Genieser
H G
HG
D000818:Animals; D000242:Cyclic AMP / Q000031:analogs & derivatives* / Q000494:pharmacology; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D004004:Dichlororibofuranosylbenzimidazole / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D010766:Phosphorylation; D010870:Pineal Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D013873:Thionucleotides / Q000494:pharmacology
D017362:Cyclic AMP Response Element-Binding Protein; D013873:Thionucleotides; C071644:5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate; C016957:adenosine-3',5'-cyclic phosphorothioate; D004004:Dichlororibofuranosylbenzimidazole; D000242:Cyclic AMP