Genetic subtypes of HIV type 1 viruses circulating in the Czech Republic.
We analyzed the genetic diversity of HIV-1 strains circulating in the Czech Republic. Phylogenetic analysis of the env and gag gene sequence fragments from 39 isolates revealed that the majority of these strains (32 of 39, 82%) were of subtype B; other genetic subtypes identified were A, C, F, and recombinant circulating form CRF01_AE. The isolates that did not cluster with subtype B originated almost exclusively from a heterosexual route of transmission. The molecular epidemiological data are suggestive of multiple entry of HIV-1 infection into the Czech Republic and show that the genetic pattern of the HIV-1 strains circulating in this country corresponds to that found in other European countries.
Reinis
M
M
National Institute of Public Health, National Reference Laboratory on AIDS, Srobárova 48, 10042 Prague 10, Czech Republic.
Brucková
M
M
Graham
R R
RR
Vandasová
J
J
Stanková
M
M
Carr
J K
JK
D000595:Amino Acid Sequence; D018153:Czech Republic / Q000453:epidemiology; D019143:Evolution, Molecular; D005260:Female; D015752:Genes, env / Q000235:genetics; D015750:Genes, gag / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny
D015699:HIV Envelope Protein gp120