Ameliorative effects of a cognitive enhancer, T-588, on place learning deficits induced by transient forebrain ischemia in rats.
In the present study, we investigated the effect of (1R)-1-benzo[b]thiophen-5-yl-2-[2-(diethylamino)ethoxy]ethan-1-ol hydrochloride (T-588), a newly synthesized cognitive enhancer, on place learning deficits in rats with damage selective to the hippocampal CA1 subfield induced by transient forebrain ischemia. Three weeks after the ischemic insult, T-588 was daily administered (0.3 or 3.0 mg/kg/day po). Place learning was tested in a task in which the rat was required to alternatively visit two places located diametrically opposite each other in an open field. The ischemic rats without the treatment of T-588 displayed severe learning impairment in this task; their performance level was significantly inferior to that of the sham-operated rats. The treatment of T-588 improved dose-dependently the task performance in ischemic rats, although no apparent protective effects on ischemic damage were found histologically. These results suggested that T-588 has ameliorative effects on learning deficits induced by brain ischemia, which could be produced through enhancement of residual cognitive functions.
Nakada
Y
Y
Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan.
Tamura
R
R
Kuriwaki
J
J
Kimura
T
T
Uwano
T
T
Nishijo
H
H
Ono
T
T
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D004048:Diethylamines / Q000494:pharmacology*; D004567:Electrodes, Implanted; D002546:Ischemic Attack, Transient / Q000523:psychology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012201:Reward; D012653:Self Stimulation; D013028:Space Perception / Q000187:drug effects; D013876:Thiophenes / Q000494:pharmacology*
D000697:Central Nervous System Stimulants; D004048:Diethylamines; D013876:Thiophenes; C082372:T 588