Induction of indoleamine 2,3-dioxygenase in vivo by IFN-con1.
Indoleamine 2,3-dioxygenase (IDO) activity as determined by increases in serum kynurenine was measured in a group of hepatitis C patients treated with consensus interferon (IFN-con1). Kynurenine levels increased significantly within 2 days of initiation of treatment but returned to normal values by week 4 after treatment. Although IDO is normally induced by IFN-gamma, no such IFN was detected by ELISA or biologic assays. Thus, consensus IFN induces low levels of IDO in vivo without an IFN-gamma intermediate.
Sweeten
T L
TL
Division of Psychiatry, Indiana University Medical School, Indianapolis, IN 46202-5121, USA.
Ferris
M
M
McDougle
C J
CJ
Kwo
P
P
Taylor
M W
MW
D004790:Enzyme Induction / Q000187:drug effects / Q000276:immunology; D006526:Hepatitis C / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007370:Interferon Type I / Q000008:administration & dosage* / Q000627:therapeutic use; D016898:Interferon-alpha; D007371:Interferon-gamma / Q000096:biosynthesis / Q000097:blood; D007737:Kynurenine / Q000494:pharmacology; D011994:Recombinant Proteins; D014364:Tryptophan / Q000097:blood; D014366:Tryptophan Oxygenase / Q000096:biosynthesis*
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007370:Interferon Type I; D016898:Interferon-alpha; D011994:Recombinant Proteins; D007737:Kynurenine; C050739:interferon alfacon-1; D007371:Interferon-gamma; D014364:Tryptophan; D014366:Tryptophan Oxygenase