[Monoamine, GABA, and glutamergic mechanisms of the anterior hypothalamus in anti-aversive effects of sedative and selective drugs in various models of anxiety].
The experiments using "illuminated site" and "threatening situation" avoidance tests on rats microinjected with GABA, glutamic acid, monoamines and their agonists and antagonists, as well as anxiosedative and anxioselective agents into the anterior hypothalamus revealed functional ambiguity in the neurochemical profile of this limbic brain formation in the anxiety states of various aversive genesis. Preliminary intraperitoneal injection of the monoamine and GABA antagonists, followed by the local administration of the antianxiety drugs studied, showed that the antiaversive action of chlordiazepoxide, fenibut, and indoter is manifested in both anxiety models via a GABAergic mechanism in the anterior hypothalamus. The anxiolytic effect of campiron is manifested only under negative-stressor zoosocial conditions and is mediated by the serotoninergic systems of this limbic brain formation.
Talalaenko
A N
AN
Pharmacology Department, Donetsk State Medical University, pr. Il'icha 16, Donetsk, 340003 Ukraine.
Gordienko
D V
DV
Markova
O P
OP
Goncharenko
N V
NV
Pankrat'ev
D V
DV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy* / Q000523:psychology; D001362:Avoidance Learning / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000037:antagonists & inhibitors / Q000494:pharmacology; D002707:Chlordiazepoxide / Q000494:pharmacology; D004195:Disease Models, Animal; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007032:Hypothalamus, Anterior / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D008845:Microinjections; D010879:Piperazines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D015306:Biogenic Monoamines; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D018755:GABA Agonists; D018756:GABA Antagonists; D006993:Hypnotics and Sedatives; D010879:Piperazines; D011743:Pyrimidines; C082647:Kampirone; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D002707:Chlordiazepoxide; C008842:4-amino-3-phenylbutyric acid