Fertility facts: male and female germ cell development requires translational control by CPEB.
In the August issue of Developmental Cell, Tay and Richter examine the consequences of eliminating CPEB function in mice. Their studies reveal an important role for this translational regulator at the pachytene stage of germ cell differentiation.
Gebauer
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Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117, Heidelberg, Germany.
Hentze
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D000818:Animals; D019926:Cyclin B / Q000235:genetics / Q000378:metabolism; D056744:Cyclin B1; D005260:Female; D005854:Germ Cells / Q000502:physiology*; D008297:Male; D008540:Meiosis / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D014176:Protein Biosynthesis; D017231:Proto-Oncogene Proteins c-mos / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D039221:mRNA Cleavage and Polyadenylation Factors
C534700:Ccnb1 protein, mouse; C490387:Cpeb1 protein, mouse; D019926:Cyclin B; D056744:Cyclin B1; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D039221:mRNA Cleavage and Polyadenylation Factors; D017231:Proto-Oncogene Proteins c-mos