title: Unique biological aspects of radiation hazards--an overview.
abstract: Low orbit, geostationary, and deep-space flights differ from one another with respect to particle radiation environment, participating population size, mission duration, and biological risks other than radiation. It is proposed that all of these factors be considered in the setting of safety standards and, in particular, that the rem-dose concept is applicable only to radiations having low and intermediate linear energy transfer (electrons, protons, and helium ions), whereas the incidence of microlesions is a more meaningful indicator of the hazard due to higher-Z, high energy (HZE) particles. A microlesion is the biological injury inflicted in a specific tissue by a single HZE particle, and it is still in need of quantitative biological definition for specific mammalian tissues. If for example, a microlesion is taken as due to a HZE particle track 10 cell diameters long with LET > 200 KeV/micrometer in its core and > 25 rad dose in its penumbra at a distance of 10 micrometers, then the microlesion dose rate in geostationary orbit, for example, is about 9,000 microlesions per cm3 of tissue per month.
authors.affiliation: The Pennsylvania State University, University Park 16802, USA.
authors.forename: P
authors.initials: P
authors.lastname: Todd
mesh_terms: D000337:Aerospace Medicine; D000818:Animals; D002468:Cell Physiological Phenomena / Q000528:radiation effects*; D003359:Cosmic Radiation; D005123:Eye / Q000528:radiation effects; D018859:Hair Follicle / Q000528:radiation effects; D006801:Humans; D018499:Linear Energy Transfer; D009381:Neoplasms, Radiation-Induced; D011829:Radiation Dosage; D018570:Risk Assessment; D019445:Solar Activity; D013026:Space Flight