Liver fibrosis attributed to lipid lowering medications: two cases.
We identified two cases of chronic active hepatitis with liver fibrosis induced by lipid lowering drugs of the statin and fibrate classes despite regular monitoring of transaminases. There are few reports of clinically significant hepatitis induced by these drugs and even fewer cases of fibrosis. Given the growing use of these drugs, there are implications for monitoring patients on long-term therapy for liver damage.
Punthakee
Z
Z
Department of Medicine, The Ottawa Hospital - Civic Campus, University of Ottawa, Ottawa, Ontario, Canada.
Scully
L J
LJ
Guindi
M M
MM
Ooi
T C
TC
D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001707:Biopsy, Needle; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006521:Hepatitis, Chronic / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D013329:Structure-Activity Relationship
D000924:Anticholesteremic Agents