[Effect of tocopherol acetate, indomethacin and dexamethasone on some indices of local lung defense in rheumatoid arthritis].
Marked disorders in the system of local lung defence are noted in experimental rheumatoid arthritis. In such a setting non-unidirectional shifts occur in the quantitative and qualitative indicators of cellular factors for the local pulmonary defensive system, characterized by discordant changes in the indicators of alveolar macrophages and segmented neutrophiles. There occur apparent disturbances in the functional activity of alveolar macrophages manifested by changes both in their phagocytary and metabolic activity and by depression of humoral mechanisms in the local pulmonary defensive system. The use of indomethacin, dexamethasone and vitamin E in an experimental rheumatoid arthritis setting favors positive shifts in indices for humoral and cellular links of the local pulmonary defensive system. Effects of vitamin E on indices for cellular and humoral links of the local pulmonary defensive system are more manifest as compared to those of indomethacin and dexamethasone.
Musaev
M U
MU
Mavlianov
I R
IR
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D008168:Lung / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D016676:Macrophages, Alveolar / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D024505:Tocopherols; D024502:alpha-Tocopherol / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D024502:alpha-Tocopherol; D024505:Tocopherols; D007213:Indomethacin