title: Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis model.
abstract: Infection of rat prostates with cytotoxic necrotizing factor type 1 (CNF1)-positive uropathogenic Escherichia coli caused more inflammation-mediated morphological and histological tissue damage than did infection with isogenic CNF1-negative mutants. These striking differences occurred despite the finding that bacterial counts for the strain pairs were indistinguishable. We conclude that CNF1 contributes to E. coli virulence in a model of acute prostatitis. To our knowledge, the results of this study provide the first demonstration of a role for any uropathogenic E. coli virulence factor in acute prostatitis.
authors.affiliation: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Rippere-Lampe
authors.forename: M
authors.initials: M
authors.lastname: Lang
authors.forename: H
authors.initials: H
authors.lastname: Ceri
authors.forename: M
authors.initials: M
authors.lastname: Olson
authors.forename: H A
authors.initials: HA
authors.lastname: Lockman
authors.forename: A D
authors.initials: AD
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000235:genetics; D003603:Cytotoxins / Q000235:genetics / Q000502:physiology*; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000150:complications / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D029968:Escherichia coli Proteins; D008297:Male; D011467:Prostate / Q000276:immunology / Q000293:injuries / Q000382:microbiology / Q000473:pathology*; D011472:Prostatitis / Q000150:complications / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D051381:Rats
chemical_list: D001427:Bacterial Toxins; D003603:Cytotoxins; D029968:Escherichia coli Proteins; C060296:cytotoxic necrotizing factor type 1