6-azacytidine--compound with wide spectrum of antiviral activity.
6-azacytidine demonstrates activity against adenoviruses types 1, 2, 5. It inhibit synthesis of viral DNA and proteins. 6-AC shows antiherpetic and antiinfluenza action during experimental infection in mice. 6-AC is prospective for drug development as an antiviral substance with a wide spectrum of activity.
Alexeeva
I
I
Institute of Molecular Biology and Genetics, Kyiv, Ukraine.
Dyachenko
N
N
Nosach
L
L
Zhovnovataya
V
V
Rybalko
S
S
Lozitskaya
R
R
Fedchuk
A
A
Lozitsky
V
V
Gridina
T
T
Shalamay
A
A
Palchikovskaja
L
L
Povnitsa
O
O
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001374:Azacitidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D020803:Encephalitis, Herpes Simplex / Q000188:drug therapy; D006367:HeLa Cells; D006561:Herpes Simplex / Q000188:drug therapy; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy; D051379:Mice
D000998:Antiviral Agents; D001374:Azacitidine; C040881:6-azacytidine