[ Studies on some physical characteristics of cyclosporine A (CyA) solid dispersions].
In this paper, poloxamer and PVP were used as carriers. CyA-poloxamer and CyA-PVP solid dispersions were prepared using the melting-solvent method or solvent method, respectively. The percentage compositions of the solid dispersions ranged from 10:90 to 90:10. Hot stage microscopy, powder X-ray diffraction and differential scanning calorimetry were used to examine the physical-chemical characteristics of the solid dispersions to provide some reliable and scientific basis for preformulation of CyA.
Zhao
H
H
Department of Pharmaceutics,  Shenyang Pharmaceutical University, Shenyang 110015.
Zheng
J M
JM
Zhang
Y H
YH
D002152:Calorimetry, Differential Scanning; D016572:Cyclosporine / Q000737:chemistry*; D014961:X-Ray Diffraction
D016572:Cyclosporine