title: Two episodes of leukoencephalitis associated with recombinant hepatitis B vaccination in a single patient.
abstract: Cases of central nervous system demyelination have been reported after recombinant hepatitis B vaccination, but no causal link has been clearly demonstrated. We present the first case report involving the occurrence of 2 episodes of leukoencephalitis in a previously healthy patient after vaccination and rechallenge with hepatitis B vaccine.
authors.affiliation: Department of Neurosurgery, Patras University Medical School, Rio, Patra, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Konstantinou
authors.forename: C
authors.initials: C
authors.lastname: Paschalis
authors.forename: T
authors.initials: T
authors.lastname: Maraziotis
authors.forename: P
authors.initials: P
authors.lastname: Dimopoulos
authors.forename: H
authors.initials: H
authors.lastname: Bassaris
authors.forename: A
authors.initials: A
authors.lastname: Skoutelis
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D005260:Female; D006509:Hepatitis B / Q000235:genetics / Q000517:prevention & control; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D011859:Radiography; D011995:Recombination, Genetic / Q000235:genetics; D014611:Vaccination
chemical_list: D017325:Hepatitis B Vaccines