Microparticle vaccine approaches to stimulate mucosal immunisation.
Entrapment of antigens in biodegradable particles for mucosal immunisation has given successful outcomes in animals, but not as yet in man. Formulations using genuinely stable biocompatible nanoparticles with co-entrapped mucosal adjuvants and/or with surface-conjugated human M-cell-targeting ligands may lead to better uptake of intact antigen by Peyer's patch M cells and delivery to antigen-presenting cells.
Brayden
D J
DJ
Elan Biotechnology Research, Biotechnology Building, Trinity College, 2, Dublin, Ireland. David.Brayden@ucd.ie
Baird
A W
AW
D000284:Administration, Oral; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D016503:Drug Delivery Systems; D006801:Humans; D018928:Immunity, Mucosal; D008081:Liposomes; D010316:Particle Size; D010581:Peyer's Patches / Q000276:immunology; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology*
D008081:Liposomes; D022223:Vaccines, Subunit