title: Comparative study on the appearance of various bioactive peptides in foregut derivates during the ontogenesis.
abstract: Bioactive peptides have an important multifunctional role in the gastrointestinal tract. In the present study we have investigated the dynamism of the appearance of PACAP (pituitary adenylate cyclase activating polypeptide), VIP (vasoactive intestinal polypeptide), gastrin, and secretin immunoreactivities in human foregut derivates during the ontogenesis using an immunohistochemical approach. None of these peptides were observed in the foregut derivates of an 8-week-old embryo. VIP immunoreactive nerve fibers appeared by the 11th week in the smooth muscle layers of the stomach. No other peptide immunoreactivities were observed of this stage. In 18- and 20-week old fetuses PACAP, secretin, and gastrin immunoreactive cells appeared in the developing glands of the stomach. In the duodenum gastrin immunoreactivity was present in the Lieberkühn's glands and secretin immunoreactive cells were seen between the surface epithelial cells. In the pancreas secretin immunoreactivity was found in the Langerhans islets; however, PACAP immunreactivity was observed in the exocrine portion. The distribution of VIP fibers did not change during the fetal life and it was similar to the adult pattern. According to our results the appearance of PACAP, secretin, and gastrin in the developing glands suggests their role in the proliferation and differentiation of the epithelial derivates.
authors.affiliation: Department of Gastroenterology, Central Hospital of the Ministry of the Interior, Városligeti fasor 9-11, Budapest, 1071 Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Vincze
authors.forename: O
authors.initials: O
authors.lastname: Kántor
authors.forename: M
authors.initials: M
authors.lastname: Kausz
authors.forename: J
authors.initials: J
authors.lastname: Németh
authors.forename: A
authors.initials: A
authors.lastname: Arimura
authors.forename: P
authors.initials: P
authors.lastname: Gonda
authors.forename: K
authors.initials: K
authors.lastname: Köves
mesh_terms: D004064:Digestive System / Q000196:embryology*; D005314:Embryonic and Fetal Development; D005333:Fetus / Q000502:physiology; D005755:Gastrins / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D009479:Neuropeptides / Q000378:metabolism*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D012633:Secretin / Q000378:metabolism*; D014018:Tissue Distribution; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
chemical_list: C495401:ADCYAP1 protein, human; D005755:Gastrins; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D012633:Secretin; D014660:Vasoactive Intestinal Peptide