[Experimental study on selective thrombolytic activity of pro-urokinase].
OBJECTIVE
To evaluate the valve of pro-urokinase as a selective thrombolytic agent in microsurgery.


METHODS
The levators muscle model in rats was used to investigate the effect of pro-urokinase on dissolving ischemic thrombi and fibrinogenolytic activities in circulation by local infusion. The tissue microcirculation, pathologic appearance of rat lungs and muscles, and general fibrinogenolytic activities were observed.


RESULTS
The thrombolytic rate of pro-urokinase was 92.3% (P < 0.05), the positive rate of D-dime was 83.3%(P < 0.05). No significant change of alpha 2-PI was observed on general fibrinogenolytic activities(P > 0.05).


CONCLUSIONS
It is suggested that pro-urokinase can be used to dissolve the thrombi in microcirculation of free tissue transplantation without affect general fibrinogenolytic activities. It is safe to use pro-urokinase in free tissue transplantation.
Tao
H
H
Department of Plastic Surgery, 455th Hospital, People's Liberation Army, Shanghai 200052, PR China.
Guo
E
E
D000818:Animals; D002196:Capillaries; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D008297:Male; D008866:Microsurgery; D009132:Muscles / Q000098:blood supply* / Q000601:surgery; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D014568:Urokinase-Type Plasminogen Activator; C067551:saruplase