Highly satisfactory procedures for the Pd-catalyzed cross coupling of aryl electrophiles with in situ generated alkynylzinc derivatives.
[reaction: see text] Two new and very efficient procedures (Procedures A and B) are reported for the Pd-catalyzed cross coupling of aryl electrophiles with terminal alkynes via their in situ conversion into alkynylzinc derivatives. Procedure A is particularly valuable in cases where electron-deficient alkynes are used, while Procedure B is operationally simple and very satisfactory in less demanding cases.
Anastasia
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Herbert C. Brown Laboratories of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Negishi Ei
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D007462:Iodobenzenes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D000480:Alkynes; D007462:Iodobenzenes; D009942:Organometallic Compounds; D010165:Palladium; D015032:Zinc