Effects of medetomidine and buprenorphine administered for sedation in dogs.
Medetomidine at doses of 10, 20 or 30 microg/kg was administered along with 10 microg/kg buprenorphine intramuscularly to 48 dogs requiring sedation for various diagnostic or therapeutic procedures. The heart rate, respiratory rate and degree of sedation were recorded before and 30 minutes after administration of the drugs. Heart rate fell by a mean of 55 per cent and respiratory rate by a mean of 62 per cent. Mean sedation scores were increased in all groups. Administration of atipamezole at the end of the period of sedation produced rapid recoveries, with a mean time to standing of 12 minutes. Animals that were anaesthetised required much less thiopentone than the 10 mg/kg recommended after premedication with acepromazine maleate.
Robinson
K J
KJ
Department of Anaesthesia, University Clinical Departments, University of Liverpool.
Jones
R S
RS
Cripps
P J
PJ
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000762:Anesthesia Recovery Period; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D007273:Injections, Intramuscular / Q000662:veterinary; D020926:Medetomidine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C050701:atipamezole; D002047:Buprenorphine; D020926:Medetomidine