Enzymatic glycosylation of lincomycin.
Lincomycin (1), a glycosidic antibiotic, active against Gram-positive bacteria, was modified enzymatically with the aim of improving its physico-chemical and biological properties. Compound 1 was glycosylated using jack bean alpha-mannosidase to produce 7-O-alpha-D-mannopyranosyl-lincomycin (2).
Weignerová
L
L
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague.
Spizek
J
J
Najmanová
L
L
Kren
V
V
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001230:Aspergillus / Q000201:enzymology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007887:Fabaceae / Q000201:enzymology; D006031:Glycosylation; D008034:Lincomycin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008358:Mannose / Q000737:chemistry; D008361:Mannosidases / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D043323:alpha-Mannosidase
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D008034:Lincomycin; D008361:Mannosidases; D043323:alpha-Mannosidase; D008358:Mannose