Outbreak of human parainfluenza virus 3 infections in a hematopoietic stem cell transplant population.
Clinical manifestations and epidemiological features are described for a cluster of 12 cases of human parainfluenza virus 3 (HPIV3) infection that occurred among 64 allogeneic hematopoietic stem cell transplant (SCT) recipients in an 11-week period during spring 2000. Upper respiratory symptoms predominated. Pneumonia occurred in 3 patients and was a contributing factor in the death of 1 patient. Exposure histories and molecular analysis of HPIV3 isolates suggested that both community acquired and nosocomially transmitted infections occurred during this outbreak. A chain of transmission within the outpatient clinic appeared to have occurred in 4 outpatients and to have extended to 2 hospitalized patients. Molecular epidemiology was useful in discerning routes of transmission in this outbreak.
Cortez
K J
KJ
Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Erdman
D D
DD
Peret
T C
TC
Gill
V J
VJ
Childs
R
R
Barrett
A J
AJ
Bennett
J E
JE
D004196:Disease Outbreaks; D015707:HN Protein / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D010224:Parainfluenza Virus 3, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010253:Respirovirus Infections / Q000453:epidemiology* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014184:Transplantation, Homologous
D015707:HN Protein