A technetium-99m-labelled cyclam acid porphyrin (CAP) for tumour imaging.
A new water-soluble cyclam acid porphyrin (CAP), 5,10,15,20-tetrakis [4-[4',8',11'-tris(carboxymethyl)-1'-(1',4',8',11'-tetraazacyclotetradecane)amidomethyleneoxy]phenyl] porphyrin has been synthesised, characterised and labelled with 99mTc. In vivo distribution studies were performed in C6-gliomas and N-nitroso-N-methylurea (NMU) induced mammary tumour bearing rats and scintiimages were obtained at 5 h post-administration of the labelled ligand using gamma camera computer system. Tumour to muscle (T/M) ratios were determined and compared with currently available tumour seeking radiopharmaceuticals such as 99mTc(V)-DMSA, 99mTc-Citrate and 201TlCl. In the case of NMU induced mammary tumour rats the ratios were 6.93, 1.97, 5.30 and 3.29; while in the case of C6-gliomas the ratios were 5.58, 2.18, 3.96 and 3.02 for 99mTc-CAP, 99mTc(V)-DMSA, 99mTc-Citrate and 203TlCl, respectively.
Murugesa
S
S
Radiation Medicine Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, India. smuru1999@yahoo.com
Shetty
S J
SJ
Srivastava
T S
TS
Noronha
O P
OP
Samuel
A M
AM
D000818:Animals; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D006573:Heterocyclic Compounds, 1-Ring; D015609:Organotechnetium Compounds; D011166:Porphyrins; D019275:Radiopharmaceuticals; C441879:technetium Tc 99 5,10,15,20-tetrakis (4-(4',8',11'-tris(carboxymethyl)-1'-(1',4',8',11'-tetraazacyclotetradecane)amidomethyleneoxy)phenyl)porphyrin; C045773:technetium Tc 99m cyclam