[Significance of soluble thrombomodulin in the coronary circulation of patients with coronary artery disease].
OBJECTIVE
The relationship between plasma levels of soluble thrombomodulin, a probable marker for endothelial damage, and the severity of coronary atherosclerosis was investigated.


METHODS
Plasma soluble thrombomodulin levels were evaluated in 160 patients(mean age 62 +/- 11 years) who underwent coronary angiography. Blood samples were obtained from the peripheral vein, ostium of the left coronary artery and coronary sinus. The levels of plasma thrombomodulin were measured by enzyme-linked immunosorbent assay. The change of thrombomodulin level in the coronary circulation (delta TM) was calculated as the coronary sino-arterial difference. Patients were classified into four groups according to the number of diseased vessels, and the severity of coronary atherosclerosis was evaluated with the modified Gensini score.


RESULTS
Coronary sinus levels of thrombomodulin were significantly higher in the two or more vessel disease(VD) groups than in the no or one VD groups(p < 0.05). delta TM were significantly higher in the 2VD than in the 0VD groups(p < 0.05), and higher in the 3VD than in the 0VD or 1VD groups(p < 0.05). delta TM showed positive correlation with Gensini score for left coronary arteries(r = 0.347, p < 0.0001).


CONCLUSIONS
The increment of thrombomodulin across the coronary circulation was significantly correlated with the severity of coronary atherosclerosis, suggesting a close association between the progression of coronary atherosclerotic stenosis and damage to the endothelial surface.
Nakagawa
I
I
First Department of Internal Medicine, Niigata University School of Medicine, Asahi-machi 1-754, Niigata, Niigata 951-8510.
Matsubara
T
T
Hori
T
T
Imai
S
S
Ozaki
K
K
Mezaki
T
T
Nasuno
A
A
Kubota
K
K
Nakano
M
M
Yamazoe
M
M
Aizawa
Y
Y
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D003326:Coronary Circulation; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D018180:Thrombomodulin / Q000097:blood*
D015415:Biomarkers; D018180:Thrombomodulin