Assessment of motor behavior using a video system and a clinical rating scale in parkinsonian monkeys lesioned by MPTP.
The best current model of Parkinson's disease is the primate treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Quantification of animal movement is important for the study of severity of parkinsonian syndrome induced by MPTP and response to drug treatments. Both require clinical rating scales that measure motor behavior with well-defined objective items. However, evaluations using these scales depend on the observer scoring the different items, according to his/her experience. The video image analyzer system, which produces an activity curve in correlation with the visual study of animal motor behavior, offers an automatic evaluation method that is observer-independent and reproducible. Using such an system we defined items correlated with those used in clinical rating scales that are sensitive to animal motor changes, decrease in movements with MPTP intoxication and alleviation afforded by levodopa: global locomotor activity and specific activities (climbing, social interactions, eating and drinking behaviors).
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Unité INSERM EMI 9904, Faculté de Médecine et Pharmacie, place Henri-Dunand, 63003, Clermont-Ferrand, France. fdurif@chu.clermontferrand.fr
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D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D001479:Basal Ganglia / Q000187:drug effects / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002908:Chronic Disease; D004185:Disability Evaluation; D004195:Disease Models, Animal; D015259:Dopamine Agents / Q000494:pharmacology; D004334:Drug Administration Schedule; D020820:Dyskinesias / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D007980:Levodopa / Q000494:pharmacology; D008253:Macaca mulatta / Q000502:physiology* / Q000601:surgery; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000503:physiopathology*; D014741:Video Recording / Q000295:instrumentation / Q000379:methods*
D000978:Antiparkinson Agents; D015259:Dopamine Agents; D007980:Levodopa; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine