NMDA receptors turn to another channel for inhibition.
Activation of glutamate receptors generally increases neuronal excitability. However, Isaacson and Murphy show in olfactory bulb granule cells that NMDA receptor-mediated calcium influx couples to large conductance (BK) calcium-activated potassium channels. The resulting inhibition is long lasting, which may be critical to the operation of the dynamic circuitry of the bulb.
Schoppa
N E
NE
Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA.
Westbrook
G L
GL
D000818:Animals; D002118:Calcium / Q000378:metabolism; D020864:Calcium Channels, N-Type / Q000502:physiology; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology*; D018698:Glutamic Acid / Q000494:pharmacology; D015640:Ion Channel Gating / Q000187:drug effects; D017136:Ion Transport / Q000187:drug effects; D051036:Large-Conductance Calcium-Activated Potassium Channels; D046911:Macromolecular Substances; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009830:Olfactory Bulb / Q000166:cytology*; D015221:Potassium Channels / Q000502:physiology*; D024681:Potassium Channels, Calcium-Activated; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D012903:Smell / Q000502:physiology
D020864:Calcium Channels, N-Type; D051036:Large-Conductance Calcium-Activated Potassium Channels; D046911:Macromolecular Substances; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D002118:Calcium