title: Microparticle vaccine approaches to stimulate mucosal immunisation.
abstract: Entrapment of antigens in biodegradable particles for mucosal immunisation has given successful outcomes in animals, but not as yet in man. Formulations using genuinely stable biocompatible nanoparticles with co-entrapped mucosal adjuvants and/or with surface-conjugated human M-cell-targeting ligands may lead to better uptake of intact antigen by Peyer's patch M cells and delivery to antigen-presenting cells.
authors.affiliation: Elan Biotechnology Research, Biotechnology Building, Trinity College, 2, Dublin, Ireland. David.Brayden@ucd.ie
authors.forename: D J
authors.initials: DJ
authors.lastname: Brayden
authors.forename: A W
authors.initials: AW
authors.lastname: Baird
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D016503:Drug Delivery Systems; D006801:Humans; D018928:Immunity, Mucosal; D008081:Liposomes; D010316:Particle Size; D010581:Peyer's Patches / Q000276:immunology; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D008081:Liposomes; D022223:Vaccines, Subunit