title: Cerebral hemodynamic changes measured by gradient-echo or spin-echo bolus tracking and its correlation to changes in ICA blood flow measured by phase-mapping MRI.
abstract: Changes in cerebral blood flow (CBF) induced by Acetazolamide (ACZ) were measured using dynamic susceptibility contrast MRI (DSC-MRI) with both spin echo (SE) EPI and gradient echo (GE) EPI, and related to changes in internal carotid artery (ICA) flow measured by phase-mapping. Also examined was the effect of repeated bolus injections. CBF, cerebral blood volume (CBV), and mean transit time (MTT) were calculated by singular value decomposition (SVD) and by deconvolution using an exponential function as kernel. The results showed no dependency on calculation method. GE-EPI measured a significant increase in CBF and CBV in response to ACZ, while SE-EPI measured a significant increase in CBV and MTT. CBV and MTT change measured by SE-EPI was sensitive to previous bolus injections. There was a significant linear relation between change in CBF measured by GE-EPI and change in ICA flow. In conclusion, GE-EPI under the present condition was superior to SE-EPI in monitoring cerebral vascular changes.
authors.affiliation: Danish Research Center for Magnetic Resonance, Hvidovre Hospital, Kettegaard Alle 30, DK-2650 Hvidovre, Denmark. marstrand@dadlnet.dk
authors.forename: J R
authors.initials: JR
authors.lastname: Marstrand
authors.forename: E
authors.initials: E
authors.lastname: Rostrup
authors.forename: S
authors.initials: S
authors.lastname: Rosenbaum
authors.forename: E
authors.initials: E
authors.lastname: Garde
authors.forename: H B
authors.initials: HB
authors.lastname: Larsson
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology; D000328:Adult; D000368:Aged; D002343:Carotid Artery, Internal / Q000033:anatomy & histology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical
chemical_list: D000086:Acetazolamide