title: Peripheral neuropathy as the presenting feature of multiple system atrophy.
abstract: The authors report a case of multiple system atrophy (MSA) with an onset as a peripheral nerve involvement. Their patient, a 55-year-old man, had a 3-year history of distal weakness and atrophy in upper limbs with dysesthesia in the feet. Other identifiable causes of peripheral neuropathy were ruled out. The authors postulate that peripheral nervous system impairment can anticipate the typical appearance of MSA, and they suggest that, in peripheral neuropathies with autonomic system dysfunction, after excluding main causes of autonomic neuropathy, MSA may need to be suspected.
authors.affiliation: Institute of Neurologic and Neurosurgical Sciences, University of Messina, Italy. crodoli@tin.it
authors.forename: C
authors.initials: C
authors.lastname: Rodolico
authors.forename: A
authors.initials: A
authors.lastname: Toscano
authors.forename: G
authors.initials: G
authors.lastname: De Luca
authors.forename: A
authors.initials: A
authors.lastname: Mazzeo
authors.forename: R
authors.initials: R
authors.lastname: Di Leo
authors.forename: S
authors.initials: S
authors.lastname: Baldari
authors.forename: P
authors.initials: P
authors.lastname: Girlanda
authors.forename: G
authors.initials: G
authors.lastname: Vita
mesh_terms: D001341:Autonomic Nervous System / Q000473:pathology; D001549:Benzamides; D003287:Contrast Media; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D011759:Pyrrolidines; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D001549:Benzamides; D003287:Contrast Media; D011759:Pyrrolidines; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide