Species differences in [11C]clorgyline binding in brain.
[11C]Clorgyline selectively binds to MAO A in the human brain. This contrasts with a recent report that [11C]clorgyline (in contrast to other labeled MAO A inhibitors) is not retained in the rhesus monkey brain [4]. To explore this difference, we compared [11C]clorgyline in the baboon brain before and after clorgyline pretreatment and we also synthesized deuterium substituted [11C]clorgyline (and its nor-precursor) for comparison. [11C]Clorgyline was not retained in the baboon brain nor was it influenced by clorgyline pretreatment or by deuterium substitution, contrasting to results in humans. This suggests a species difference in the susceptibility of MAO A to inhibition by clorgyline and represents an unusual example of where the behavior of a radiotracer in the baboon brain does not predict its behavior in the human brain.
Fowler
J S
JS
Brookhaven National Laboratory, Upton, New York 11973, USA. fowler@bnl.gov
Ding
Y S
YS
Logan
J
J
MacGregor
R R
RR
Shea
C
C
Garza
V
V
Gimi
R
R
Volkow
N D
ND
Wang
G J
GJ
Schlyer
D
D
Ferrieri
R
R
Gatley
S J
SJ
Alexoff
D
D
Carter
P
P
King
P
P
Pappas
N
N
Arnett
C D
CD
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000201:enzymology / Q000378:metabolism*; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D003010:Clorgyline / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D003903:Deuterium; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007202:Indicators and Reagents; D007553:Isotope Labeling; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000493:pharmacokinetics*; D010215:Papio; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D013045:Species Specificity; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D007202:Indicators and Reagents; D008996:Monoamine Oxidase Inhibitors; D019275:Radiopharmaceuticals; D003903:Deuterium; D008995:Monoamine Oxidase; D003010:Clorgyline