title: Cytotoxic and novel compounds from Solanum indicum.
abstract: Solavetivone (1), cytotoxic to OVCAR-3 cells with an IC(50) value of 0.1 mM, has been isolated from Solanum indicum. In addition, a novel solafuranone (2) and three known compounds, scopoletin, N-(p-trans-coumaroyl)tyramine, and N-trans-feruloyltyramine, were isolated for the first time from this plant. The structures of the above compounds were established by means of spectroscopic and X-ray analyses.
authors.affiliation: Institute of Microbiology and Immunology, National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: W J
authors.initials: WJ
authors.lastname: Syu
authors.forename: M J
authors.initials: MJ
authors.lastname: Don
authors.forename: G H
authors.initials: GH
authors.lastname: Lee
authors.forename: C M
authors.initials: CM
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002845:Chromatography; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D008968:Molecular Conformation; D015394:Molecular Structure; D010051:Ovarian Neoplasms; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D019657:Solanaceae / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects; D012717:Sesquiterpenes; D013141:Spiro Compounds; D000094162:Phytoalexins
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; C438422:solafuranone; C438421:solavetivone; D012717:Sesquiterpenes; D013141:Spiro Compounds; D000094162:Phytoalexins