Asymmetric synthesis of a fully protected ent-actinoidinic acid.
[structure: see text] The asymmetric synthesis of a fully protected ent-actinoidinic acid derivative 14 is described. As key steps, an enantioselective deprotonation of an arene tricarbonylchromium(0) complex and a diastereoselective Suzuki coupling were applied. The asymmetric centers of the amino acid function were created via stereocontrolled Strecker reactions.
Wilhelm
R
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Department of Chemistry, Imperial College of Science Technology and Medicine, London SW7 2AZ, UK.
Widdowson
D A
DA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014640:Vancomycin / Q000031:analogs & derivatives / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; C012164:actinoidins; D014640:Vancomycin