title: Exercise in sickle cell anemia: effect on inflammatory and vasoactive mediators.
abstract: The aim of this study was to determine the response of inflammatory and vasoactive mediators to 3 consecutive days of exercise in African-American women with and without sickle cell anemia (SCA). Circulating inflammatory mediators [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha)] were measured before, and vasoactive mediators [endothelin-1 (ET-1), nitric oxide metabolites (NOx)] before and after each exercise bout in ten subjects with SCA and ten controls. Exercise did not affect ET-1, IL-6 or CRP concentrations (p >.05). TNFalpha was higher in SCA than controls (p < or = .0005) at all times; however, the response pattern was similar for the groups: no change from day 1 to day 2, but a decrease from day 2 to day 3 (p < or = .05). NOx increased significantly after exercise (p < or = .0001) but returned to baseline by 24 h afterward. On the 3rd day, NOx increased after exercise in SCA but not in the controls (p < or = .05). In conclusion, exercise did not cause a harmful inflammatory response in these individuals with SCA. However, NOx increased after exercise on all 3 days in SCA but appeared attenuated after 2 days in controls.
authors.affiliation: Georgia Prevention Institute, Medical College of Georgia, Augusta 30912, USA. pbarbeau@mail.mcg.edu
authors.forename: P
authors.initials: P
authors.lastname: Barbeau
authors.forename: K F
authors.initials: KF
authors.lastname: Woods
authors.forename: L T
authors.initials: LT
authors.lastname: Ramsey
authors.forename: M S
authors.initials: MS
authors.lastname: Litaker
authors.forename: D M
authors.initials: DM
authors.lastname: Pollock
authors.forename: J S
authors.initials: JS
authors.lastname: Pollock
authors.forename: L A
authors.initials: LA
authors.lastname: Callahan
authors.forename: A
authors.initials: A
authors.lastname: Kutlar
authors.forename: G A
authors.initials: GA
authors.lastname: Mensah
authors.forename: B
authors.initials: B
authors.lastname: Gutin
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D019332:Endothelin-1 / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise; D005260:Female; D005454:Fluorescence Polarization; D006339:Heart Rate; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D015850:Interleukin-6 / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D010146:Pain / Q000175:diagnosis; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D006454:Hemoglobins; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D002097:C-Reactive Protein