title: [Effectiveness of fenspiride in patients with chronic obstructive bronchitis].
abstract: Patients with chronic obstructive pulmonary disease of moderate severity were investigated for two months for assessment of fenspiride activity. Examination of the patients (age 42.6 +/- 5.3) took place before and after fenspiride therapy. In comparison to the control group, fenspiride patients showed improvement of external respiration function: FEV 1, FVC, FEF 50-75, PEF increased. Dienic conjugates, malonic dialdehyde levels decreased, alpha-tocopherol in platelet membranes rose, functional activity of platelets fell. Side effects were rare and not serious. It is concluded that fenspiride has an antiinflammatory effect, reduces bronchoconstriction and depresses platelet aggregation, is well tolerated. Fenspiride is an effective drug for the treatment of moderate chronic obstructive bronchitis.
authors.forename: T D
authors.initials: TD
authors.lastname: Shorokhova
authors.forename: I V
authors.initials: IV
authors.lastname: Medvedeva
authors.forename: S V
authors.initials: SV
authors.lastname: Lapik
authors.forename: O G
authors.initials: OG
authors.lastname: Solov'eva
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Gracheva
authors.forename: R S
authors.initials: RS
authors.lastname: Iusupova
mesh_terms: D000328:Adult; D029481:Bronchitis, Chronic / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D010366:Peak Expiratory Flow Rate / Q000502:physiology; D013141:Spiro Compounds / Q000627:therapeutic use*
chemical_list: D001993:Bronchodilator Agents; D013141:Spiro Compounds; C084775:fenspiride