New multiflorane-type triterpenoid acids from Sandoricum indicum.
Three new 12beta-hydroxymultiflorane triterpenoid acids, sandorinic acids A-C (1-3), were isolated from the stem bark of Sandoricum indicum together with five known triterpenes (4-8). The structures of 1-3 were elucidated by spectral data interpretation. Compounds 1-8 were evaluated for their inhibiting activity against several tumor cell lines and for their effects on lymphocyte proliferation.
Tanaka
T
T
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Koyano
T
T
Kowithayakorn
T
T
Fujimoto
H
H
Okuyama
E
E
Hayashi
M
M
Komiyama
K
K
Ishibashi
M
M
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D004317:Doxorubicin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D007945:Leukemia, Lymphoid; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013785:Thailand; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014750:Vincristine / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C438626:sandorinic acid A; C438627:sandorinic acid B; C438628:sandorinic acid C; D014750:Vincristine; D004317:Doxorubicin