BCG vaccination to prevent implantation of endometriosis: an experimental study in rats.
To investigate whether BCG vaccination can prevent endometrial implantation in a rat model. Forty sexually mature virgin Wistar-Albino rats weighing 185-215g were randomly assigned (double-blind) to two groups. The first group (n=20) were injected with BCG 3 weeks before endometrial implantation to the eye. The second group (n=20) with BCG not injected before endometrial implantation was the control. Photobiomicroscopy observation was done weekly and 6 weeks post endometrial implantation all eyes were investigated histologically.Five implants grew in the anterior surface of the iris of the first (vaccinated) group and 17 in the second (control) group. The difference was statistically significant. Systemic prophylaxis with BCG can exert an inhibitory effect on endometrial transplantation.
Gül
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Department of Obstetrics and Gynecology, Faculty of Medicine, Yüzüncü Yil University, 65200 Van, Turkey.
Yaşar
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Uğraş
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D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D004715:Endometriosis / Q000276:immunology / Q000517:prevention & control*; D004717:Endometrium / Q000637:transplantation; D005260:Female; D007498:Iris / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar
D001500:BCG Vaccine