Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome.
Fourteen drug-naive and 11 levodopa-treated patients with idiopathic restless legs syndrome (RLS), and 10 controls age-matched to each RLS group separately were examined with polysomnography (PSG), [(123)I]-(N)-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane ((123)I-IPT) SPECT, and [(123)I]-(S)-2-hydroxy-3-iodo-6-methoxy-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide ((123)I-IBZM) SPECT. Drug-naive and levodopa-treated patients with RLS and controls showed similar striatal dopamine transporter and dopamine D(2)-receptor binding, the latter declining with age. The authors conclude that striatal dopamine transporter and receptor density is normal in drug-naive and levodopa-treated patients with RLS.
Eisensehr
I
I
Department of Neurology, Ludwig-Maximilians University, Munich, Germany. eisen@nefo.med.uni-muenchen.de
Wetter
T C
TC
Linke
R
R
Noachtar
S
S
von Lindeiner
H
H
Gildehaus
F J
FJ
Trenkwalder
C
C
Tatsch
K
K
D000368:Aged; D001549:Benzamides; D015259:Dopamine Agents / Q000008:administration & dosage*; D018492:Dopamine Antagonists; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007980:Levodopa / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011759:Pyrrolidines; D012148:Restless Legs Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
D001549:Benzamides; D015259:Dopamine Agents; D018492:Dopamine Antagonists; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D014326:Tropanes; C087210:N-(3-iodopropen-1-yl)-2-carbomethoxy-3-(4-chlorophenyl)tropane; D007980:Levodopa; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide