title: [A giant testicular tumor detected with dyspnea due to lung metastases: a case report].
abstract: A 19-year-old male presented with dyspnea. Clinical examination revealed the left infant-head-sized testicular tumor, multiple lung metastases and retroperitoneal bulky lymph node metastasis with marked elevation of serum lactic dehydrogenase (LDH) and alpha-fetoprotein. Left radical orchiectomy followed by the chemotherapy with etoposide and cisplatin (EP) for 4 cycles was performed. The tumor weighed 1,700 g, and was pathologically diagnosed as mixed germ cell tumor consisting of embryonal carcinoma and yolk sac tumor. After the treatment, the tumor markers were normalized with partial response (PR) of lung metastases and complete response (CR) of retroperitoneal lymph node metastasis. Thereafter, biopsy of lung metastases through video-assisted thoracoscopic surgery (VATS) was performed, and pathologically no viable cells were detected. Five months after the treatment, he was seized with convulsion due to brain metastasis with hemorrhage. Therefore, a surgical resection of brain metastasis and 2nd line chemotherapy with etoposide, ifosfamide and cisplatin (VIP) chemotherapy for 3 cycles was performed. The patient has been free of recurrence for 21 months after the 2nd line chemotherapy.
authors.affiliation: Department of Urology, Minoh Municipal Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Tsujikawa
authors.forename: N
authors.initials: N
authors.lastname: Murosaki
authors.forename: H
authors.initials: H
authors.lastname: Sugao
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Takao
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
authors.forename: T
authors.initials: T
authors.lastname: Miki
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D018236:Carcinoma, Embryonal / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D004417:Dyspnea / Q000209:etiology*; D018240:Endodermal Sinus Tumor / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D009378:Neoplasms, Multiple Primary; D009919:Orchiectomy; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy
chemical_list: D005047:Etoposide; D002945:Cisplatin