A multicentric study with arteether in patients of uncomplicated falciparum malaria.
Two hundred and sixty seven patients of uncomplicated P. falciparum malaria completed study in a multicentric phase III clinical trial of Arteether. Arteether was given intramuscularly in a dose of 150 mg daily for three consecutive days. Each patient was followed upto 28 days of alpha, beta arteether therapy. The cure rate was 97% with fever clearance time between 1-7 days (24-168 hours) and parasite clearance time between 1-3 days (24-72 hours). Parasite reappearance rate was found to be 3% and reported at only three of the centres. Following the treatment no adverse effect was observed on haematological, biochemical and vital clinical parameters.
Asthana
O P
OP
Central Drug Research Institute, Lucknow, India.
Srivastava
J S
JS
Kamboj
V P
VP
Valecha
N
N
Sharma
V P
VP
Gupta
S
S
Pande
T K
TK
Vishwanathan
K A
KA
Mahapatra
K M
KM
Nayak
N C
NC
Mahapatra
P K
PK
Mahanta
J
J
Srivastava
V K
VK
Vasdev
Singh
N
N
Shukla
M M
MM
Balsara
A B
AB
Mishra
S K
SK
Satpathy
S K
SK
Mohanty
S
S
Dash
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012717:Sesquiterpenes / Q000627:therapeutic use*
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C055141:artemotil