Modified iridoid glycosides as anti-implantation agents: inhibition of cell adhesion as an approach for developing pregnancy interceptive agents.
Structural modifications in iridoid glycosides and evaluation of their efficacy on adhering capability (in vitro) of immature hamster uterine epithelial cells to the substratum have been studied. Out of 31, eight compounds in vitro, five compounds in utero and two in vivo showed adhesion/implantation preventing activity, respectively. The results provide an indication for further exploration in the line of development of anti-adhesive agents.
Misra
A P
AP
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Mathad
V T
VT
Raj
K
K
Bhaduri
A P
AP
Tiwari
R
R
Srivastava
A
A
Mehrotra
P K
PK
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects; D005260:Female; D005960:Glucosides / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D006027:Glycosides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D039823:Iridoids; D008647:Mesocricetus; D011714:Pyrans / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014599:Uterus / Q000166:cytology / Q000187:drug effects
D003271:Contraceptive Agents, Female; D005960:Glucosides; D006027:Glycosides; D039823:Iridoids; D011714:Pyrans