Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta.
PPARbeta is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARbeta heterozygous mice reveal that PPARbeta is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.
Michalik
L
L
Institut de Biologie Animale, Université de Lausanne, Bâtiment de Biologie, Lausanne, Switzerland.
Desvergne
B
B
Basu-Modak
S
S
Tan
N S
NS
Wahli
W
W
D000818:Animals; D002455:Cell Division / Q000502:physiology; D004817:Epidermis / Q000254:growth & development / Q000378:metabolism; D006579:Heterozygote; D006706:Homeostasis / Q000502:physiology*; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics; D009154:Mutation / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology*; D012867:Skin / Q000293:injuries / Q000503:physiopathology; D012879:Skin Physiological Phenomena; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors