Effects of AH-9700, (+)-pentazocine, DTG and oxybutynin on micturition in anesthetized rats with acetone-induced cystitis.
We investigated the effects of AH-9700 (1-[2-(3,4-dihydro-6,7-dimethyl-2-naphthalenyl)ethyl] pyrrolidine fumarate; a novel sigma receptor ligand), (+)-pentazocine and 1,3-di-o-tolylguanidine (DTG) (two typical sigma receptor ligands), and oxybutynin (a currently used anti-pollakiuria drug) on cystometrograms in anesthetized rats with 30% acetone-induced cystitis. Compared to sham-treated rats, acetone-treated cystitis models exhibited an increase in urinary frequency during continuous filling cystometry. Intravenous administration of AH-9700 (1-5 mg/kg), (+)-pentazocine or DTG to the rats with cystitis dose-dependently prolonged micturition intervals and increased the micturition threshold pressure. Oxybutynin (1 mg/kg. i.v.) also extended micturition intervals, but decreased the micturition pressure. These results indicate that AH-9700, (+)-pentazocine and DTG improve abnormal frequent urination caused by acetone-induced cystitis in a manner different from that of oxybutynin.
Shimizu
I
I
Department of Pharmacology 1, Dainippon Pharmaceutical Co., Ltd., Suita/Osaka, Japan. isao-shimizu@dainippon-pharm.co.jp
Kawashima
K
K
Ishii
D
D
Oka
M
M
D000096:Acetone / Q000009:adverse effects*; D000758:Anesthesia; D000818:Animals; D003556:Cystitis / Q000139:chemically induced / Q000503:physiopathology*; D004195:Disease Models, Animal; D005650:Fumarates / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D008297:Male; D008333:Mandelic Acids / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology*; D010423:Pentazocine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014554:Urination / Q000187:drug effects*
D005650:Fumarates; D006146:Guanidines; D008333:Mandelic Acids; D009281:Naphthalenes; D000096:Acetone; C437044:1-(2-(3,4-dihydro-6,7-dimethyl-2-naphthalenyl)ethyl) pyrrolidine fumarate; C005419:oxybutynin; C050232:1,3-ditolylguanidine; D010423:Pentazocine