title: Influence of antisocial personality subtypes on drug abuse treatment response.
abstract: This methodological study examined the impact of antisocial personality disorder (APD) and other psychiatric comorbidity on drug use and treatment retention in 513 new admissions to methadone maintenance treatment. Patients were classified into one of four groups: APD ONLY, APD plus other psychiatric disorder (APD MIXED), other psychiatric disorder, and no psychiatric disorder. Patients completed research assessments and were then followed for 1 year of treatment. Patients with APD had longer histories of heroin and cocaine use than non-APD patients and were more likely to meet criteria for cocaine dependence. Distinct clinical profiles emerged that differentiated APD ONLY from APD MIXED. APD ONLY patients exhibited higher rates of cocaine and heroin use, whereas those with APD MIXED exhibited higher rates of benzodiazepine use. Self-report measures supported urinalysis results, but group differences did not affect treatment retention. These differences in clinical profiles should be considered when evaluating treatment performance in substance abusers with APD.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.
authors.forename: V L
authors.initials: VL
authors.lastname: King
authors.forename: M S
authors.initials: MS
authors.lastname: Kidorf
authors.forename: K B
authors.initials: KB
authors.lastname: Stoller
authors.forename: J A
authors.initials: JA
authors.lastname: Carter
authors.forename: R K
authors.initials: RK
authors.lastname: Brooner
mesh_terms: D000328:Adult; D000987:Antisocial Personality Disorder / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology*; D001294:Attitude to Health; D015897:Comorbidity; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012720:Severity of Illness Index; D015813:Substance Abuse Detection / Q000706:statistics & numerical data; D016320:Substance Abuse Treatment Centers; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D016896:Treatment Outcome