title: Base-of-tongue cancer: survival, function, and quality of life after external-beam irradiation and brachytherapy.
abstract: OBJECTIVE
  Base-of-tongue cancer has traditionally been treated by surgical resection followed by radiation therapy. Primary radiation therapy with brachytherapy has recently been proposed as an alternative. In a prior analysis, we found that patients with advanced tongue-base cancer treated by total glossectomy and postoperative radiation therapy can be cured while potentially maintaining good quality of life. Therefore, we designed the current study to assess survival, function, and quality of life in our patients with tongue-base cancer who were treated with primary radiation therapy and brachytherapy with neck dissection as indicated.
  
  
  METHODS
  Consecutive case series.
  
  
  METHODS
  Twenty patients were treated between 1993 and 1997 using the approach just named. The T stages were T1 (3), T2 (10), T3 (6), and T4 (1). The N stages were N0 (3), N1 (3), N2 (11), and N3 (3). At the time of brachytherapy catheter placement, neck dissections were performed in all 14 patients with N2 or N3 disease. Surviving patients completed a functional status survey and quality of life questionnaire.
  
  
  RESULTS
  The 3- and 5-year Kaplan-Meier corrected actuarial survival rates were 57% and 38%, respectively. Eight patients remained alive at the time of this writing and completed the functional status survey and quality of life assessment. Function and quality of life were well maintained in patients treated with external-beam irradiation followed by brachytherapy and neck dissection. However, none of our patients with T3 disease had long-term survival.
  
  
  CONCLUSIONS
  Although we do not endorse external-beam irradiation and brachytherapy for advanced tongue-base cancers, this treatment should be strongly considered for patients with T1 or T2 tumors in whom preservation of function and quality of life is a priority.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The University of Cincinnati Medical Center, 213 Bethesda Avenue, Cincinnati, OH 45267-0528, U.S.A.
authors.forename: M L
authors.initials: ML
authors.lastname: Robertson
authors.forename: L L
authors.initials: LL
authors.lastname: Gleich
authors.forename: W L
authors.initials: WL
authors.lastname: Barrett
authors.forename: J L
authors.initials: JL
authors.lastname: Gluckman
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011879:Radiotherapy Dosage; D014062:Tongue Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D016896:Treatment Outcome