title: Extent of coronary atherosclerosis and homocysteine affect endothelial markers.
abstract: The aim of the study was to evaluate the effects of the presence, extent, and clinical stability of coronary artery disease on endothelial function parameters, C-reactive protein and homocysteine levels. Fifty-eight patients with angiographically documented coronary artery disease and 25 patients with normal coronary arteries were evaluated for risk factors, plasma homocysteine, C-reactive protein, and soluble adhesion molecule levels. Vascular cell adhesion molecule-1 and sE-selectin were significantly higher in the group with coronary artery disease than in healthy subjects (p = 0.005 and p = 0.031, respectively). Patients with unstable angina had significantly higher C-reactive protein (p < 0.001), troponin I (p < 0.01), and leukocyte counts (p < 0.05) than those with stable angina. sE-selectin levels were correlated with the extent of coronary atherosclerosis (r = 0.444, p < 0.05), and plasma homocysteine levels were associated with vascular cell adhesion molecule-1 (r = 0.479, p < 0.05) in unstable cases. These results suggest that vascular cell adhesion molecule-1 and sE-selectin are useful for determining the presence of coronary atherosclerosis, whereas C-reactive protein, troponin 1, and leukocyte count are predictors of clinical stability.
authors.affiliation: Hacettepe University, Department of Cardiology, Ankara, Turkey. ayliny@ato.org.tr
authors.forename: A
authors.initials: A
authors.lastname: Yildirir
authors.forename: S L
authors.initials: SL
authors.lastname: Tokgozoglu
authors.forename: I
authors.initials: I
authors.lastname: Haznedaroglu
authors.forename: I
authors.initials: I
authors.lastname: Sinici
authors.forename: G
authors.initials: G
authors.lastname: Kabakci
authors.forename: K
authors.initials: K
authors.lastname: Ovunc
authors.forename: S
authors.initials: S
authors.lastname: Aksoyek
authors.forename: A
authors.initials: A
authors.lastname: Oto
authors.forename: F
authors.initials: F
authors.lastname: Ozmen
authors.forename: S
authors.initials: S
authors.lastname: Kirazli
authors.forename: S
authors.initials: S
authors.lastname: Kes
mesh_terms: D000789:Angina, Unstable / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D019040:E-Selectin / Q000097:blood; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D006710:Homocysteine; D002097:C-Reactive Protein