title: Human immunodeficiency virus-positive patients with posterior intracorneal precipitates.
abstract: OBJECTIVE
  To describe an unusual and possibly new keratopathy in human immunodeficiency virus (HIV)-positive patients.
  
  
  METHODS
  Retrospective observational case series.
  
  
  METHODS
  : Six HIV-positive patients at four centers.
  
  
  METHODS
  A complete medical history was obtained and a thorough ophthalmic examination was performed on each of the patients.
  
  
  RESULTS
  Each patient had bilaterally symmetrical keratopathy consisting of variably pigmented round and reticular posterior intracorneal precipitates at the level of Descemet's membrane. The precipitates were diffuse, but larger and more prominent near the limbus and finer toward the central cornea. None of the eyes were inflamed, and all had normal vision. No patient had uveitis on presentation or any history of cytomegalovirus retinitis.
  
  
  CONCLUSIONS
  These patients have a unique posterior keratopathy, which requires further investigation.
authors.affiliation: Department of Ophthalmology, New York Medical College, Valhalla, New York, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Chu
authors.forename: G W
authors.initials: GW
authors.lastname: Zaidman
authors.forename: D M
authors.initials: DM
authors.lastname: Meisler
authors.forename: C
authors.initials: C
authors.lastname: Lowder
authors.forename: D S
authors.initials: DS
authors.lastname: Jacobs
authors.forename: C J
authors.initials: CJ
authors.lastname: Rapuano
authors.forename: G J
authors.initials: GJ
authors.lastname: Green
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003316:Corneal Diseases / Q000175:diagnosis / Q000209:etiology*; D003886:Descemet Membrane / Q000473:pathology*; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000209:etiology*; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014792:Visual Acuity
chemical_list: D000998:Antiviral Agents