Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis.
To determine the effects of sepsis on cerebral energy metabolism, the cerebrospinal fluid adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, hypoxanthine, xanthine, and urate concentrations were determined by high-performance liquid chromatography and the neuron-specific enolase levels by means of an enzyme immunoassay method in 32 children with sepsis, without meningitis, aged between 2 months and 13 years, and in 160 age-matched controls. The septic group had significantly higher cerebrospinal fluid concentrations of inosine, adenosine, xanthine, and urate than controls. These results suggest that sepsis could provoke some degree of neuronal hypoxia and significant alterations of cerebral energy metabolism homeostasis.
Rodríguez-Núñez
A
A
Department of Pediatrics, Hospital Clínico Universitario de Santiago, Complejo Hospitalario, Santiago de Compostela, Spain.
Cid
E
E
Rodríguez-García
J
J
Camiña
F
F
Rodríguez-Segade
S
S
Castro-Gago
M
M
D000293:Adolescent; D002545:Brain Ischemia / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009705:Nucleosides / Q000134:cerebrospinal fluid*; D009711:Nucleotides / Q000134:cerebrospinal fluid*; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*; D011237:Predictive Value of Tests; D011687:Purines / Q000134:cerebrospinal fluid*; D012016:Reference Values; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D014527:Uric Acid / Q000134:cerebrospinal fluid*
D009705:Nucleosides; D009711:Nucleotides; D011687:Purines; D014527:Uric Acid; D010751:Phosphopyruvate Hydratase