title: Knockout models resulting in the development of obesity.
abstract: Our understanding of body weight regulation has been greatly advanced by the characterization of previously existing mutations in mice that cause obesity. Subsequent analysis of a number of mouse knockout models has greatly expanded the number of genes known to influence adiposity by affecting metabolic rate, physical activity, and/or appetite.
authors.affiliation: Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Butler
authors.forename: R D
authors.initials: RD
authors.lastname: Cone
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D012739:Gonadal Steroid Hormones / Q000235:genetics; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009478:Neuropeptide Y / Q000235:genetics; D018377:Neurotransmitter Agents / Q000235:genetics; D009765:Obesity / Q000209:etiology / Q000235:genetics*; D011333:Pro-Opiomelanocortin / Q000235:genetics; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics; D018043:Receptors, Corticotropin / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D044101:Receptors, Melanocortin; D017476:Receptors, Neuropeptide Y / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
chemical_list: D012739:Gonadal Steroid Hormones; D009478:Neuropeptide Y; D018377:Neurotransmitter Agents; D022702:Receptors, Adrenergic, beta-3; D018043:Receptors, Corticotropin; D018160:Receptors, Cytoplasmic and Nuclear; D044101:Receptors, Melanocortin; D017476:Receptors, Neuropeptide Y; D014157:Transcription Factors; D011333:Pro-Opiomelanocortin