title: Association between oxidative stress and bone mineral density.
abstract: Free radicals have been shown to be involved in bone resorption in vitro and in rodents. We studied the effect of oxidative stress on bone mineral density (BMD) in 48 women and 53 men from a population-based study. The levels of 8-iso-PGF(2alpha) (a major F(2)-isoprostane and a biomarker of oxidative stress) and a control, 15-keto-dihydro-PGF(2alpha) (a biomarker of inflammatory response), were measured in urinary samples and their association with BMD and quantitative ultrasound (QUS) measurements were examined. In multivariate linear regression analyses, 8-iso-PGF(2alpha) levels were negatively associated with both BMD and QUS. In contrast, no association was found for 15-keto-dihydro-PGF(2alpha). Our findings establish a biochemical link between increased oxidative stress and reduced bone density and provide a rational for further studies investigating the role of pro- and antioxidants in osteoporosis.
authors.affiliation: Sections of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S-751 25 Uppsala, Sweden. samar.basu@geriatrik.uu.se
authors.forename: S
authors.initials: S
authors.lastname: Basu
authors.forename: K
authors.initials: K
authors.lastname: Michaëlsson
authors.forename: H
authors.initials: H
authors.lastname: Olofsson
authors.forename: S
authors.initials: S
authors.lastname: Johansson
authors.forename: H
authors.initials: H
authors.lastname: Melhus
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D015519:Bone Density; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000652:urine; D028441:F2-Isoprostanes / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers; D028441:F2-Isoprostanes; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost