title: DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions.
abstract: The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface.
authors.affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: S
authors.initials: S
authors.lastname: Pöhlmann
authors.forename: G J
authors.initials: GJ
authors.lastname: Leslie
authors.forename: T G
authors.initials: TG
authors.lastname: Edwards
authors.forename: T
authors.initials: T
authors.lastname: Macfarlan
authors.forename: J D
authors.initials: JD
authors.lastname: Reeves
authors.forename: K
authors.initials: K
authors.lastname: Hiebenthal-Millow
authors.forename: F
authors.initials: F
authors.lastname: Kirchhoff
authors.forename: F
authors.initials: F
authors.lastname: Baribaud
authors.forename: R W
authors.initials: RW
authors.lastname: Doms
mesh_terms: D015704:CD4 Antigens / Q000032:analysis; D015815:Cell Adhesion Molecules; D006678:HIV / Q000502:physiology*; D016655:HIV Core Protein p24 / Q000032:analysis; D015658:HIV Infections / Q000635:transmission*; D006801:Humans; D037102:Lectins / Q000502:physiology*; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface / Q000502:physiology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015704:CD4 Antigens; D015815:Cell Adhesion Molecules; D016655:HIV Core Protein p24; D037102:Lectins; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C433029:CLEC4M protein, human