A comparison between microsatellite analysis and cytology of urine for the detection of bladder cancer.
We have studied, in a blinded fashion, cytology and microsatellite analysis on urine sediments of 143 Chinese with or without bladder lesions. Microsatellite analysis succeeded in all 143 individuals, while cytology could not be performed on 42 subjects due to insufficient urine samples. Both microsatellite analysis and routine urine cytology succeeded in 81 bladder cancer patients. Seventy-three patients (90%) were identified by microsatellite analysis, while only 41 patients (51%) were identified by cytology. However, four patients were identified by routine cytology but not by microsatellite analysis. Our results proved that microsatellite analysis is more sensitive than routine cytology but the two methods are complementary to each other.
Zhang
J
J
Department of Chemical Etiology and Carcinogenesis, Cancer Institute (Hospital), Chinese Academy of Medical Sciences and Peking Union Medical College, P.O. Box 2258, Beijing 100021, People's Republic of China.
Zheng
S
S
Fan
Z
Z
Gao
Y
Y
Di
X
X
Wang
D
D
Xiao
Z
Z
Li
C
C
An
Q
Q
Cheng
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D015233:Models, Statistical; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000652:urine*