title: [Plasma levels of soluble fibrin in patients with disseminated intravascular coagulation].
abstract: Soluble fibrin(SF) is formed in the early-activated state of blood coagulation and quantitative measurement of SF shows high potential as a parameter for the diagnosis of suspected disseminated intravascular coagulation(DIC). The aim of the present study is to evaluate the usefulness of a newly developed SF test utilizing SF specific monoclonal antibody(F405). Among hemopoietic and non-hemopoietic tumor patients, 249 patients with suspected DIC were collected. The SF level showed a good correlation with the DIC score and the SF levels in DIC patients were significantly higher than those in s-DIC and pre-DIC patients. Receiver operating characteristic(ROC) analysis also showed that the specificity and sensitivity of the SF assay were higher than those of thrombin-antithrombin complex(TAT). In conclusion, these results indicate that the SF assay is a highly precise method for the diagnosis and screening of DIC stages.
authors.affiliation: Second Department of Internal Medicine, Mie University, Tsu 514-8507.
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Sakakura
authors.forename: R
authors.initials: R
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Nakazaki
authors.forename: H
authors.initials: H
authors.lastname: Shiku
authors.forename: J
authors.initials: J
authors.lastname: Nishioka
authors.forename: T
authors.initials: T
authors.lastname: Nobori
mesh_terms: D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005337:Fibrin / Q000032:analysis*; D006801:Humans
chemical_list: D005337:Fibrin