Evidence that selenium deficiency results in the cytoplasmic decay of GPx1 mRNA dependent on pre-mRNA splicing proteins bound to the mRNA exon-exon junction.
Studies of transcripts for the selenoprotein glutathione peroxidase 1 (GPx1) have provided remarkable evidence for the coupling of pre-mRNA splicing in the nucleus and mRNA translation in the cytoplasm. Such evidence derives from the initial finding that GPx1 mRNA is a natural substrate of nonsense-mediated decay. Here, recent work on GPx1 RNA metabolism is reviewed and future directions of study are defined.
Maquat
L E
LE
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 712 Rochester, NY 14642, USA. lynne_maquat@urmc.rochester.edu
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D005091:Exons; D005979:Glutathione Peroxidase / Q000235:genetics*; D007438:Introns; D011506:Proteins / Q000235:genetics; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics*; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism; D051140:Selenoproteins; D014158:Transcription, Genetic; D000094765:Glutathione Peroxidase GPX1
D011506:Proteins; D012333:RNA, Messenger; D051140:Selenoproteins; D005979:Glutathione Peroxidase; D012643:Selenium; D000094765:Glutathione Peroxidase GPX1