Intrathecal midazolam increases the analgesic effects of spinal blockade with bupivacaine in patients undergoing haemorrhoidectomy.
In the present double-blind study we aimed to evaluate the postoperative analgesic effects of intrathecal midazolam with bupivacaine following haemorrhoidectomy. Forty-five patients were randomly allocated to one of three groups: the control group received 1 ml of 0.5% heavy bupivacaine plus 0.2 ml of 0.9% saline intrathecally, group BM1 received 1 ml of 0.5% bupivacaine plus 0.2 ml of 0.5% preservative-free midazolam and group BM2 received 1 ml of 0.5% bupivacaine plus 0.4 ml of 0.5% midazolam. Time to first analgesia was significantly greater in the midazolam groups than in the placebo and significantly less in the BM1 group than in the BM2 group.
Kim
M H
MH
Department of Anaesthesiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Lee
Y M
YM
D000759:Adjuvants, Anesthesia; D000328:Adult; D000775:Anesthesia, Spinal / Q000379:methods; D000779:Anesthetics, Local; D002045:Bupivacaine; D004311:Double-Blind Method; D005260:Female; D006484:Hemorrhoids / Q000601:surgery*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D011183:Postoperative Complications
D000759:Adjuvants, Anesthesia; D000779:Anesthetics, Local; D008874:Midazolam; D002045:Bupivacaine