[Linkage disequilibrium analysis of chromosome 22 and schizophrenia in a Chinese population].
OBJECTIVE
To explore the molecular genetic relations of chromosome 22 and schizophrenia and locate the susceptibility gene of schizophrenia.


METHODS
Six dinucleotide tandem repeat loci on chromosome 22 were chosen to analyze 126 affected sib-pair nuclear families of schizophrenia in Chinese population by fluorescent labeled auto-mated genotyping and transmission/ disequilibrium test(TDT).


RESULTS
The TDT-chi square value of IL2Rbeta was 25.30(P=0.01), which suggests there is linkage disequilibrium between IL2R beta and schizophrenia. The P vaules of the other five loci (D22S944, D22S264, D22S303, D22S278 and CYP2D6) were greater than 0.05.


CONCLUSIONS
A susceptive gene of schizophrenia may be located in IL2Rbeta locus or adjacent region.
Cai
G
G
Institute of Mental Health, The First Affiliated Hospital, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P.R. China. caiguiqing@21cn.com
Li
T
T
Deng
H
H
Wu
M
M
Liu
X
X
Collier
D A
DA
D002892:Chromosomes, Human, Pair 22; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D012559:Schizophrenia / Q000235:genetics*