[Plasma levels of soluble fibrin in patients with disseminated intravascular coagulation].
Soluble fibrin(SF) is formed in the early-activated state of blood coagulation and quantitative measurement of SF shows high potential as a parameter for the diagnosis of suspected disseminated intravascular coagulation(DIC). The aim of the present study is to evaluate the usefulness of a newly developed SF test utilizing SF specific monoclonal antibody(F405). Among hemopoietic and non-hemopoietic tumor patients, 249 patients with suspected DIC were collected. The SF level showed a good correlation with the DIC score and the SF levels in DIC patients were significantly higher than those in s-DIC and pre-DIC patients. Receiver operating characteristic(ROC) analysis also showed that the specificity and sensitivity of the SF assay were higher than those of thrombin-antithrombin complex(TAT). In conclusion, these results indicate that the SF assay is a highly precise method for the diagnosis and screening of DIC stages.
Wada
H
H
Second Department of Internal Medicine, Mie University, Tsu 514-8507.
Takeda
Y
Y
Sakakura
M
M
Watanabe
R
R
Nakazaki
T
T
Shiku
H
H
Nishioka
J
J
Nobori
T
T
D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005337:Fibrin / Q000032:analysis*; D006801:Humans
D005337:Fibrin