title: [Injection pain from propofol-MCT-LCT in children. A comparison with propofol-LCT].
abstract: OBJECTIVE
  This prospective, randomised, double-blind study was designed to compare the incidence and intensity of pain on injection of propofol formulated in a mixture of medium- and long-chain triglycerides, Propofol-MCT/LCT 1% (Propofol-Lipuro, B. Braun, Germany) with propofol in a commonly used emulsion of long-chain triglycerides, Propofol-LCT 1% (Disoprivan, Zeneca) in children undergoing elective surgical procedures.
  
  
  METHODS
  After approval of the local ethics committee 40 children, aged 7-14 years, were enrolled in the study. Premedication was with 5-10 mg diazepam orally one hour before induction of anesthesia. In the beginning 20% of the calculated dose of Propofol for induction was injected into a separate venous cannula in a dorsal vein of the hand; patients were observed for expressing pain spontaneously during injection patients or were asked to describe the sensations after 10 s. Withdrawal of the arm during injection was also noted.
  
  
  RESULTS
  Significantly more children reported pain on injection of propofol-LCT compared to Propofol-MCT/LCT (25% vs, 10%) and significantly more children retracted their arm during injection of propofol-LCT (40% vs. 10%).
  
  
  CONCLUSIONS
  Propofol-MCT/LCT 1% (Propofol-Lipuro) for induction of anesthesia produced significantly less pain on injection and significantly less drawing back of the arm when compared to Propofol-LCT (Disoprivan). Thus, with respect to pain on injection Propofol-MCT/LCT appears to be superior to Propofol-LCT in children aged 7-14 years.
authors.affiliation: Klinik für Anästhesiologie und Intensivmedizin, Universitätskliniken des Saarlandes, Kirrbergerstrasse, 66421 Homburg/Saar. airlar@med-rz.uni-sb.de
authors.forename: R
authors.initials: R
authors.lastname: Larsen
authors.forename: U
authors.initials: U
authors.lastname: Beerhalter
authors.forename: R
authors.initials: R
authors.lastname: Erdkönig
authors.forename: B
authors.initials: B
authors.lastname: Larsen
mesh_terms: D000293:Adolescent; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004311:Double-Blind Method; D004655:Emulsions; D005079:Excipients; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000209:etiology*; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D014280:Triglycerides
chemical_list: D018686:Anesthetics, Intravenous; D004655:Emulsions; D005079:Excipients; D014280:Triglycerides; D015742:Propofol