Two episodes of leukoencephalitis associated with recombinant hepatitis B vaccination in a single patient.
Cases of central nervous system demyelination have been reported after recombinant hepatitis B vaccination, but no causal link has been clearly demonstrated. We present the first case report involving the occurrence of 2 episodes of leukoencephalitis in a previously healthy patient after vaccination and rechallenge with hepatitis B vaccine.
Konstantinou
D
D
Department of Neurosurgery, Patras University Medical School, Rio, Patra, Greece.
Paschalis
C
C
Maraziotis
T
T
Dimopoulos
P
P
Bassaris
H
H
Skoutelis
A
A
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D005260:Female; D006509:Hepatitis B / Q000235:genetics / Q000517:prevention & control; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D011859:Radiography; D011995:Recombination, Genetic / Q000235:genetics; D014611:Vaccination
D017325:Hepatitis B Vaccines