Acute mercuric chloride poisoning: effect of co-ingested milk on outcome and continued hyperamylasemia.
Thirty-six h after intentionally ingesting 25 g of mercuric chloride powder mixed with 5O mL of milk, an elderly woman presented to the emergency department with diffuse upper gastrointestinal erosions and acute renal failure. The patient was treated with dimercaprol and hemodialysis, and was discharged from the hospital without clinically apparent sequelae. However, elevated serum concentrations of amylase and proteases persisted for several months despite normal findings by computed tomography including contrast administration. Delayed absorption and weakened corrosive effect may have resulted from the binding of mercuric chloride to thiol-containing proteins in milk, improving the clinical outcome.
Kamijo
Y
Y
Department of Emergency and Critical Care Medicine, Kitasato University, School of Medicine, Sagamihara Kanagawa, Japan.
Soma
K
K
Yosimura
K
K
Ohwada
T
T
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001665:Binding Sites; D002614:Chelating Agents / Q000627:therapeutic use; D004112:Dimercaprol / Q000627:therapeutic use; D004202:Disinfectants / Q000493:pharmacokinetics / Q000506:poisoning*; D004347:Drug Interactions; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D008627:Mercuric Chloride / Q000493:pharmacokinetics / Q000506:poisoning*; D008892:Milk; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000139:chemically induced; D016896:Treatment Outcome
D002614:Chelating Agents; D004202:Disinfectants; D004112:Dimercaprol; D008627:Mercuric Chloride