The renaissance of GSK3.
Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of cell functions. The study of the substrate specificity and regulation of GSK3 activity has been important in the quest for therapeutic intervention.
Cohen
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MRC Protein Phosphorylation Unit and Division of Signal Transduction Therapy, School of Life Sciences, University of Dundee, DD1 5EH, Scotland, UK. p.cohen@dundee.ac.uk
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D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D004331:Drosophila melanogaster / Q000196:embryology; D004625:Embryo, Nonmammalian / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006003:Glycogen / Q000096:biosynthesis; D038341:Glycogen Synthase Kinases; D006801:Humans; D007328:Insulin / Q000502:physiology; D010766:Phosphorylation; D014176:Protein Biosynthesis; D015398:Signal Transduction; D013379:Substrate Specificity
D004791:Enzyme Inhibitors; D007328:Insulin; D006003:Glycogen; D038341:Glycogen Synthase Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases