title: A report of a rare immediate reaction after ingestion of acetaminophen.
abstract: BACKGROUND
  Acetaminophen hypersensitivity is rare and, when seen, is usually in association with sensitivity to nonsteroidal anti-inflammatory drugs.
  
  
  METHODS
  This is a case report of an immediate reaction to acetaminophen, confirmed by a drug challenge, in a subject who tolerated ibuprofen.
  
  
  RESULTS
  After an oral challenge with 50 mg of acetaminophen, the subject had generalized pruritus, urticaria, and dyspnea.
  
  
  CONCLUSIONS
  This patient demonstrates a rare but potentially severe reaction to acetaminophen that may occur in patients who are not otherwise sensitive to other nonsteroidal anti-inflammatory drugs.
authors.affiliation: University of Iowa, Iowa City 52242, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Grant
authors.forename: J M
authors.initials: JM
authors.lastname: Weiler
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen