Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells.
Ca(2+) signal in high-Ca(2+) perimitochondrial microdomains is amplified within the mitochondrial matrix and activates Ca(2+)-dependent dehydrogenases. In steroid-secreting cells, small cytoplasmic Ca(2+) signals may also augment mitochondrial Ca(2+) concentration. The ensuing formation of NADH and NADPH may have an essential role in supporting the increased steroid secretion.
Spät
A
A
Department of Physiology, Faculty of Medicine, Semmelweis University, H-1444 Budapest, Hungary.
Pitter
J G
JG
Rohács
T
T
Szabadkai
G
G
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism*
D013256:Steroids