Anti-emetics for cancer chemotherapy-induced emesis: Potential of alternative delivery systems.
Currently, the most commonly used routes of administration of antiemetics in chemotherapeutic regimens are oral and intravenous. Patient compliance and thus efficacy of conventional drug schedules and formulations are often impaired by difficulties associated with oral or intravenous uptake of the administered chemotherapy. Alternative or new drug delivery systems should overcome these problems by improving patient compliance. Several new drug delivery systems are available and development of these new systems is ongoing, in particular to meet delivery requirements of modern biological therapeutics and the application of gene therapy. However, at the present time, the implementation of new techniques of alternative antiemetic drug administration for chemotherapy-induced emesis is very limited. The challenge for clinical investigations to further develop new delivery systems, in particular for antiemetic therapies, remains.
Kraut
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Clinic of Bone Marrow Transplantation and Haematology/Oncology, Idar-Oberstein, Germany.
Fauser
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AA
D000328:Adult; D000932:Antiemetics / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002626:Chemistry, Pharmaceutical; D002648:Child; D016503:Drug Delivery Systems; D006801:Humans; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*
D000932:Antiemetics; D000970:Antineoplastic Agents