title: Does longevity in beagles injected with bone-seeking radionuclides depend upon radiation dose in the absence of known radiation effects?
abstract: Regression analyses of longevity as a function of skeletal radiation dose among groups of beagles injected with 226Ra, 228Ra, 228Th, 241Am, 90Sr or monomeric 239Pu suggested that at low doses and dose-rates (those at which induced effects are low), age at death seems to be independent of dose when animals dying with specific radiation effects were excluded, although longevity does appear to be a function of dose when animals dying with established radiation effects and at all doses were included. We conclude tentatively that, for mammals receiving skeletal dose from bone-seeking radionuclides at low doses and low dose-rates, longevity may not be dependent upon skeletal radiation dose in the absence of radiation-induced malignancies or other radiation effects.
authors.affiliation: Department of Radiology, University of Utah, Salt Lake City 84108-1218, USA. ray.lloyd@hsc.utah.edu
authors.forename: R D
authors.initials: RD
authors.lastname: Lloyd
authors.forename: S C
authors.initials: SC
authors.lastname: Miller
authors.forename: G N
authors.initials: GN
authors.lastname: Taylor
mesh_terms: D000576:Americium / Q000493:pharmacokinetics; D000818:Animals; D001842:Bone and Bones / Q000502:physiology* / Q000528:radiation effects*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008136:Longevity; D008297:Male; D011005:Plutonium / Q000493:pharmacokinetics; D011868:Radioisotopes / Q000493:pharmacokinetics*; D011883:Radium / Q000493:pharmacokinetics; D013324:Strontium / Q000493:pharmacokinetics; D013910:Thorium / Q000493:pharmacokinetics
chemical_list: D011868:Radioisotopes; D011005:Plutonium; D013910:Thorium; D000576:Americium; D011883:Radium; D013324:Strontium