title: Sclerotherapy with picibanil (OK-432) for congenital lymphatic malformation in the head and neck.
abstract: OBJECTIVE
  Congenital lymphatic malformations of the head and neck (LMHN) present special challenges to the otolaryngologist-head and neck surgeon. Recently, a number of sclerotherapy trials have shown promising results. In this study, we present our experiences with picibanil (OK-432) sclerotherapy for this lesion.
  
  
  METHODS
  Retrospectively review.
  
  
  METHODS
  We retrospectively reviewed 21 patients who have undergone sclerotherapy with picibanil for LMHN.
  
  
  RESULTS
  Satisfactory response with complete or nearly complete shrinkage of the lesions was observed in 15 cases after repeated sclerotherapy (average, two times). We did not observe any significant morbidity or complications in the patients treated with picibanil. Reduction in size of the mass was achieved in weeks to months. Some of the patients who had not had any other previous treatment showed remarkable reductions in size even after the first therapy. When we used picibanil sclerotherapy as a primary treatment for the LMHN, most of our patients showed satisfactory results regardless of the size or location of the lesions.
  
  
  CONCLUSIONS
  Given with our experience and the reports that failure of picibanil sclerotherapy does not hinder subsequent surgical salvage procedures, we recommend trying picibanil sclerotherapy as a primary treatment for the LMHN and performing surgical excision as a secondary modality if the response to the sclerotherapy is not satisfactory.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu Seoul, Korea, 110-744.
authors.forename: M W
authors.initials: MW
authors.lastname: Sung
authors.forename: D W
authors.initials: DW
authors.lastname: Lee
authors.forename: D Y
authors.initials: DY
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Hwang
authors.forename: S W
authors.initials: SW
authors.lastname: Park
authors.forename: K H
authors.initials: KH
authors.lastname: Kim
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006257:Head; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D008208:Lymphatic System / Q000002:abnormalities*; D008297:Male; D008875:Middle Aged; D009333:Neck; D010844:Picibanil / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D012597:Sclerosing Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D015911:Sclerotherapy
chemical_list: D012597:Sclerosing Solutions; D010844:Picibanil