Decreased susceptibility to pentylenetetrazol-induced seizures after low-frequency transcranial magnetic stimulation in rats.
We studied the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on seizure susceptibility in rats. rTMS of 1000 pulses at 0.5 Hz led to a prolonged latency for seizure development after an intraperitoneal injection of pentylenetetrazol. The rTMS effectively prevented the development of status epilepticus of pentylenetetrazol-induced convulsions. These findings indicate that low-frequency rTMS affects the neural excitability, in the direction of anticonvulsive, and therefore, suggest the possibility of therapeutic use of rTMS in epilepsy.
Akamatsu
N
N
Department of Neurology, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. akamatn@med.uoeh-u.ac.jp
Fueta
Y
Y
Endo
Y
Y
Matsunaga
K
K
Uozumi
T
T
Tsuji
S
S
D000818:Animals; D003292:Convulsants / Q000494:pharmacology*; D004351:Drug Resistance; D004558:Electric Stimulation; D004569:Electroencephalography; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation
D003292:Convulsants; D010433:Pentylenetetrazole