Dopaminergic neurotransmission and restless legs syndrome: a genetic association analysis.
In order to examine the genetic substrate of the dopamine hypothesis in restless legs syndrome, we analyzed eight genes coding for receptors and enzymes related to dopaminergic transmission, using a population of 92 patients with restless legs syndrome and 182 controls matched for ethnic background. No significant differences were found in the genotypic or allelic distributions between groups. Furthermore, no effect of the loci examined was observed with stratification using clinical parameters such as age at onset or periodic leg movements during sleep index.
Desautels
A
A
Centre d'étude du sommeil, Hôpital du Sacré Coeur de Montréal, Université de Montréal, Canada.
Turecki
G
G
Montplaisir
J
J
Ftouhi-Paquin
N
N
Michaud
M
M
Chouinard
V A
VA
Rouleau
G A
GA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada; D016022:Case-Control Studies; D004298:Dopamine / Q000235:genetics* / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism; D012148:Restless Legs Syndrome / Q000235:genetics* / Q000378:metabolism*; D009435:Synaptic Transmission / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics
D011954:Receptors, Dopamine; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine