[Effect of sanchinoside Rg1 on experimental thrombosis and its mechanisms].
The effect of sanchinoside Rg1 on generation of thrombosis and its mechanism was studied. Rg1 was shown to markedly inhibit experimental thrombosis formation induced by extra corporeal shunt between the carotid artery and jugular vein. After Rg1 infusion, the activity of t-PA was found to be increased, so did the percentage of active-type t-PA, but the activity of PA-I decreased. Further data in our study indicate that incubation of endothelial cells with Rg1 for 24 h caused significant increase of NO production. This effect was found to be dose-dependent. These observations suggest that Rg1 is a potent anti-thrombosis substance and can enhance the function of fibrinolysis system and stimulate vascular endothelial cells to release NO.
Xu
H L
HL
Department of Cardiovascular Pharmacology, Nanjing Medical University, 210029.
Liu
W B
WB
Rao
M R
MR
D000818:Animals; D001011:Aorta / Q000166:cytology / Q000378:metabolism; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D036145:Ginsenosides; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D015849:Plasminogen Inactivators / Q000097:blood*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000494:pharmacology*; D010959:Tissue Plasminogen Activator / Q000097:blood*; D020246:Venous Thrombosis / Q000097:blood*
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D015849:Plasminogen Inactivators; D012503:Saponins; D009569:Nitric Oxide; D010959:Tissue Plasminogen Activator; C035054:ginsenoside Rg1