title: Pharmacokinetic interactions of nevirapine and methadone and guidelines for use of nevirapine to treat injection drug users.
abstract: Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7-10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.
authors.affiliation: Department of Genitourinary Medicine, St. James's Hospital, Dublin, Ireland. Susan.Clarke@bmc.org
authors.forename: S M
authors.initials: SM
authors.lastname: Clarke
authors.forename: F M
authors.initials: FM
authors.lastname: Mulcahy
authors.forename: J
authors.initials: J
authors.lastname: Tjia
authors.forename: H E
authors.initials: HE
authors.lastname: Reynolds
authors.forename: S E
authors.initials: SE
authors.lastname: Gibbons
authors.forename: M G
authors.initials: MG
authors.lastname: Barry
authors.forename: D J
authors.initials: DJ
authors.lastname: Back
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004336:Drug Antagonism; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008875:Middle Aged; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics; D019829:Nevirapine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017410:Practice Guidelines as Topic; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015819:Substance Abuse, Intravenous / Q000150:complications* / Q000188:drug therapy
chemical_list: D000701:Analgesics, Opioid; D019380:Anti-HIV Agents; D009292:Narcotic Antagonists; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine; D008691:Methadone