Use of antibacterial agents in renal failure.
This article reviews the pharmacokinetics of antibacterial agents in patients with normal and decreased renal function. The concepts of volume and distribution, rate of elimination, loading and maintenance doses, and therapeutic drug monitoring are delineated. Special reference is made to the intermittent dosing of cefazolin with hemodialysis. Newer, as well as traditional methods of extracorporeal circulation and the resultant changes in antibacterial agent pharmacodynamics are discussed.
Livornese
L L
LL
Department of Medicine, Medical College of Pennsylvania, Hahnemann University, School of Medicine, Philadelphia, USA.
Slavin
D
D
Benz
R L
RL
Ingerman
M J
MJ
Santoro
J
J
D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000075202:Contraindications; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008433:Mathematics; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000188:drug therapy* / Q000628:therapy
D000890:Anti-Infective Agents