[HLA molecules, immunity and gestation].
During pregnancy, the fetus develops particularly efficient molecular regulatory mechanisms to prevent possible maternal anti-paternal alloimmune response and avoid viral spreading from maternal tissue. Among the different mechanisms, there has been noted a selective expression of HLA molecules on trophoblast cells: the absence of HLA class II and of polymorphic HLA-A and HLA-B expression but presence of both non polymorphic HLA-G and HLA-E class Ib as well as of HLA-C class Ia. The functional consequences of such a particular pattern of HLA expression in gestation are examined here.
Le Bouteiller
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Institut national de la santé et de la recherche médicale, unité 395, centre hospitalo-universitaire de Purpan, BP 3028, 31024 Toulouse, France. phil.lb@purpan.inserm.fr
D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007109:Immunity; D010920:Placenta / Q000276:immunology / Q000821:virology; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II