title: Obesity and autologous stem cell transplantation in acute myeloid leukemia.
abstract: In the bone marrow transplant setting, several authors hypothesized that severely overweight patients are at increased risk of transplant-related toxicity, but different definitions of obesity, different body weight groupings and heterogeneous samples of patients were analyzed. To overcome these limitations, we retrospectively considered a homogeneous group of 54 patients (median age 36.5 years), with a diagnosis of de novo acute myeloid leukemia (AML), autografted in first complete remission (CR) with the Bu-Cy2 conditioning regimen, dosed on actual body weight. Patients were classified into three groups (obese, non-obese, underweight) using body mass index (BMI = kg/m(2)); for each group we analyzed transplant-related toxicity and mortality, overall survival and disease-free survival (OS/DFS). In spite of the relatively small number of patients, in our results high BMI appears a predictive factor for an increase of treatment-related toxicity and mortality. Moreover, 30 (55%) patients are currently alive in continuous CR, and after a median follow-up of 76.5 months (range 14-137) statistically significant differences in OS and DFS were detected between obese and non-obese groups (P = 0.012 and 0.021, respectively). Our study suggests that obesity may represent an independent risk factor for autograft in AML and further investigations are warranted.
authors.affiliation: Department of Biotecnologie Cellulari ed Ematologia, University La Sapienza, Roma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Meloni
authors.forename: A
authors.initials: A
authors.lastname: Proia
authors.forename: S
authors.initials: S
authors.lastname: Capria
authors.forename: A
authors.initials: A
authors.lastname: Romano
authors.forename: G
authors.initials: G
authors.lastname: Trapé
authors.forename: S M
authors.initials: SM
authors.lastname: Trisolini
authors.forename: M
authors.initials: M
authors.lastname: Vignetti
authors.forename: F
authors.initials: F
authors.lastname: Mandelli
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000401:mortality / Q000503:physiopathology*; D012189:Retrospective Studies; D015996:Survival Rate; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000401:mortality; D014182:Transplantation, Autologous