title: The role of cytochrome P450-mediated drug-drug interactions in determining the safety of statins.
abstract: The objectives of this review are to discuss the role of cytochrome P450 (CYP450) isoforms in drug metabolism, to explain differences in metabolism among the HMG-CoA reductase inhibitors (HMGs, statins), to review drug-drug and drug-food interaction studies dealing with the HMGs, to present case reports dealing with HMG-related myopathy, to discuss major clinical implications of these case reports and to express an opinion of use of HMGs in clinical practice.
authors.affiliation: Department of Pharmacy, University of Cincinnati, Ohio, USA. crw@skilledcare.com
authors.forename: C R
authors.initials: CR
authors.lastname: Worz
authors.forename: M
authors.initials: M
authors.lastname: Bottorff
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004110:Diltiazem / Q000494:pharmacology; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007527:Isoenzymes / Q000378:metabolism; D017964:Itraconazole / Q000494:pharmacology; D008148:Lovastatin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced; D017035:Pravastatin / Q000037:antagonists & inhibitors; D012206:Rhabdomyolysis / Q000139:chemically induced; D019821:Simvastatin / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D007527:Isoenzymes; D017964:Itraconazole; D003577:Cytochrome P-450 Enzyme System; D008148:Lovastatin; D019821:Simvastatin; D004110:Diltiazem; D017035:Pravastatin