The effect on adipose tissue blood flow of isoenergetic meals containing different amounts and types of fat.
OBJECTIVE
To investigate the factors regulating the increase in adipose tissue blood flow following meals.


METHODS
Eight subjects were fed three isoenergetic meals; two high-fat meals rich in either saturated or polyunsaturated fatty acids and one low-fat, high-carbohydrate meal.


METHODS
Blood samples were taken and adipose tissue blood flow was measured before and for 6 h after the meal. Plasma glucose, insulin, non-esterified fatty acid, total and chylomicron-triacylglycerol and catecholamine concentrations were measured.


RESULTS
Adipose tissue blood flow rose to a peak after all three meals (P<0.05 for each). The three meals stimulated adipose tissue blood flow at similar times. There was a marked and statistically significant similarity in the time course of changes in blood flow and insulin concentrations. In contrast, noradrenaline concentrations peaked later than adipose tissue blood flow (P=0.014).


CONCLUSIONS
Adipose tissue blood flow may be 'carbohydrate-stimulated' rather than 'fat-stimulated', with insulin having a vasodilatory role in adipose tissue as in skeletal muscle.
Summers
L K
LK
Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK.
Callow
J
J
Samra
J S
JS
Macdonald
I A
IA
Matthews
D R
DR
Frayn
K N
KN
D000273:Adipose Tissue / Q000098:blood supply*; D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood; D002914:Chylomicrons / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002395:Catecholamines; D002914:Chylomicrons; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides