title: [Isolated neurologic disorders disclosing Biermer's disease in young subjects].
abstract: BACKGROUND
  In young subjects, the discovery of a cobalamine deficiency (Biermer's disease) at the time of neuropsychiatric disorders even of isolated MRI anomalies is a rare event (less than 0.01%).
  
  
  METHODS
  We report two observations of cobalamine deficiency, in patients 30 and 37 years old, revealed by acroparesthesia and spontaneous hypersignal in the T2 sequence of MRI and by a peripheral sensitive neuropathy respectively.
  
  
  CONCLUSIONS
  The neuropsychiatric demonstrations of pernicious anemia are polymorphic with, sometimes, isolated spinothalamic attacks. The MRI can contribute to the diagnosis but more often leads to an erroneous diagnosis. Our observations are of special interest because symptoms occurred apart from supplementation of folates and recovered ad integrum with an early treatment by vitamin B12.
authors.affiliation: Service de médecine interne, hôpitaux universitaires de Strasbourg, hôpital de Hautepierre, avenue Molière, 67098 Strasbourg, France.
authors.forename: E
authors.initials: E
authors.lastname: Andrès
authors.forename: V
authors.initials: V
authors.lastname: Renaux
authors.forename: F
authors.initials: F
authors.lastname: Campos
authors.forename: C
authors.initials: C
authors.lastname: Opréa
authors.forename: C
authors.initials: C
authors.lastname: Sonntag-Fohrer
authors.forename: J M
authors.initials: JM
authors.lastname: Warter
authors.forename: P
authors.initials: P
authors.lastname: Dufour
authors.forename: F
authors.initials: F
authors.lastname: Maloisel
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology*; D014806:Vitamin B 12 Deficiency / Q000150:complications*