title: Solid-phase synthesis of beta-amino ketones and six-ring carbamates via immobilized alpha-alkoxycarbonylamino sulfones.
abstract: [reaction: see text] beta-Amino ketones and substituted 1,3-oxazinan-2-ones have been synthesized utilizing polymer-bound and carbamate-linked alpha-alkoxycarbonylamino sulfones. Key steps in the synthesis are the immobilization of the N-acylimine precursor, the Mannich-type addition of various nucleophiles, and the diastereoselective reduction of the resin-bound ketone.
authors.affiliation: Institut für Organische Chemie, Rheinisch-Westfälische Technische Hochschule, Professor-Pirlet-Strasse 1, 52074 Aachen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schunk
authors.forename: D
authors.initials: D
authors.lastname: Enders