[Inhibition of beta-amyloid precursor protein gene expression by haifengteng].
OBJECTIVE
To study the inhibition of beta-amyloid precursor protein(beta-APP) gene expression by Haifengteng.


METHODS
Northern Blot analysis was used to investigate the level of beta-APP mRNA, and cell viability, LDH-release and colony formation assay were used to study the effect of Hairengteng of neurons.


RESULTS
Haifengteng inhibited the expression of beta-APP gene selectively without causing cell injuries.


CONCLUSIONS
beta-APP is closely related to Alzheimer's disease. The findings in this study could be a basis for Haifengteng to have therapeutic potentials in treating Alzheimer's disease.
Han
E
E
Department of Neurology, Affiliated Hospital of Shandong Medical University, Jinan 250012.
Rajiv
J
J
D016564:Amyloid beta-Protein Precursor / Q000096:biosynthesis* / Q000235:genetics; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015870:Gene Expression; D006801:Humans; D019684:Magnoliopsida; D009447:Neuroblastoma / Q000473:pathology; D010946:Plants, Medicinal; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger