title: Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population.
abstract: We have analyzed a sample of 40 centenarians and 116 young controls from Sardinia, with a set of new Y chromosome binary markers, to evaluate if Y chromosome genes are involved in the high prevalence of males among centenarian Sardinians (1/2 vs. 1/4 in other populations studied). The results indicate that none of the seven lineages that account for >97% of the Y chromosome diversity in Sardinia provide an advantage with respect to the extreme longevity. However, our results, although based on the male-specific Y chromosome polymorphisms, give a clear profile of the pattern of genetic variability in Sardinia. Indeed they indicate that the Sardinian population had two main founder populations that have evolved in isolation for at least the last 5,000 years. These findings set the stage for future studies on longevity and other complex traits in Sardinia.
authors.affiliation: Department of Genetics, Stanford University, Stanford, CA, USA. g.passarino@unical.it
authors.forename: G
authors.initials: G
authors.lastname: Passarino
authors.forename: P A
authors.initials: PA
authors.lastname: Underhill
authors.forename: L L
authors.initials: LL
authors.lastname: Cavalli-Sforza
authors.forename: O
authors.initials: O
authors.lastname: Semino
authors.forename: G M
authors.initials: GM
authors.lastname: Pes
authors.forename: C
authors.initials: C
authors.lastname: Carru
authors.forename: L
authors.initials: L
authors.lastname: Ferrucci
authors.forename: M
authors.initials: M
authors.lastname: Bonafè
authors.forename: C
authors.initials: C
authors.lastname: Franceschi
authors.forename: L
authors.initials: L
authors.lastname: Deiana
authors.forename: G
authors.initials: G
authors.lastname: Baggio
authors.forename: G
authors.initials: G
authors.lastname: De Benedictis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D007558:Italy; D015810:Linkage Disequilibrium; D008297:Male; D010802:Phylogeny; D011110:Polymorphism, Genetic; D014998:Y Chromosome
chemical_list: D005819:Genetic Markers