title: History of the development and use of biological weapons.
abstract: The United States began its BW program based on intelligence information and a very thorough evaluation of that information by a panel of scientists, engineers, medical personnel from a variety of areas including the military, other government agencies, industry, and the academic community. Initial efforts were directed toward defense against BW, but it soon became clear defense required a knowledge of offensive capabilities. The initial offensive studies started with a definition of what infectious organisms were available, how they could grow in quantities to support a munitions program, what kind of facilities were required, and where they could be positioned. Further studies were then initiated to design and evaluate testing sites and methodologies to evaluate the weapons. During all of these phases, concurrent medical and safety programs were studied, emphasized, and implemented. These studies resulted in the development of a number of vaccines, toxoids, treatments, therapies, and facility personnel management. The US program had one of the lowest, if not the lowest, personnel lost time because of personnel infections. The overall conclusion was that BW, offensive and defensive, was possible, and efficiencies could be obtained. The work accomplished by this group of very dedicated military and civilian personnel at military installations, universities, research institutes, and industrial organizations presented truly a combined operation with numerous achievements. Many of the detailed achievements were published in the open scientific, peer-reviewed journals, and many patents were obtained. The current defensive program is breaking new scientific ground and there is evidence indicating that very rapid detection and identification of BW agents is possible and will be instrumented.
authors.affiliation: Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. amarty@usuhs.mil
authors.forename: A M
authors.initials: AM
authors.lastname: Marty
mesh_terms: D001694:Biological Warfare / Q000266:history*; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049691:History, Medieval; D006801:Humans; D008887:Military Medicine / Q000266:history*; D014481:United States