[Role of apoptosis in age-related pathologies].
A review of recent data concerning the apoptotic death of cells during senescence at the organismic level. The data analyzed suggest interrelations between apoptosis deregulation and some age-related pathologies and senescent phenotypes. Genetic aspects and possible mechanisms of age-related changes in the program of apoptosis are considered. It has been proposed that age-related deregulation of apoptosis is a mechanism of senescence.
Zainyllin
V G
VG
Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, ul. Kommunisticheskaya 28, Syktyvkar, 167982 Russia.
Moskalev
A A
AA
D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016922:Cellular Senescence; D005786:Gene Expression Regulation; D006801:Humans; D009928:Organ Specificity; D014898:Werner Syndrome / Q000235:genetics / Q000473:pathology