Allergic contact dermatitis and its relationship to carcinogenicity.
The relationship between allergic contact dermatitis (ACD) and carcinogenicity was investigated using a recently developed and validated simulation approach. The analyses indicated that while there are electrophilic and non-electrophilic components to ACD, these were not identical to those operating in carcinogenicity. Accordingly, with respect to carcinogenicity prediction, the results of ACD do not improve the results based upon mutagenicity testing alone, the latter being a surrogate for potential electrophilicity.
Rosenkranz
H S
HS
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. rsnkranz@pitt.edu
D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000737:chemistry / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000209:etiology*; D004563:Electrochemistry; D006801:Humans; D008954:Models, Biological; D009152:Mutagenicity Tests; D013329:Structure-Activity Relationship
D002273:Carcinogens