title: Usefulness of concurrent Papanicolaou smear at time of cervical biopsy.
abstract: The reliability and cost-effectiveness of a repeat Papanicolaou (Pap) smear performed at the time of colposcopic biopsy is uncertain. To evaluate the usefulness of this practice, Pap smear and biopsy results of 718 patients were reviewed and compared: 619 patients had Pap smears performed prior to colposcopy with a 1.1% false-negative rate, 97.5% sensitivity, and 83.6% positive predictive value. Ninety-nine patients had Pap smears performed at the time of colposcopy with a 19.1% false-negative rate, 56.8% sensitivity, and 92.6% positive predictive value. Repeat Pap smear at the time of colposcopy resulted in significant changes in the management of only 2 patients (2%) and more careful follow-up in one (1%). Pap smears performed at colposcopic biopsy are less sensitive than those done prior to biopsy (P < 0.001). The clinical benefit of this practice is marginal, considering the added costs and potential detrimental effects to the colposcopic examination, provided patients receive adequate follow-up.
authors.affiliation: Department of Pathology, St. John Hospital and Medical Center, Detroit, Michigan 48236, USA. jcpanos@pol.net
authors.forename: J C
authors.initials: JC
authors.lastname: Panos
authors.forename: B A
authors.initials: BA
authors.lastname: Jones
authors.forename: P F
authors.initials: PF
authors.lastname: Mazzara
mesh_terms: D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology*; D003127:Colposcopy; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013997:Time Factors; D014626:Vaginal Smears / Q000706:statistics & numerical data*