Leber hereditary optic neuropathy, progressive visual loss, and multiple-sclerosis-like symptoms.
OBJECTIVE
To report a case of Leber hereditary optic neuropathy with multiple-sclerosis-like symptoms.


METHODS
Observational case report. A 34-year-old man was found to have Leber hereditary optic neuropathy and a mutation at position 11778 of the mitochondrial genome. The progression of vision loss and onset of weakness in the right leg warranted neuroimaging.


RESULTS
Magnetic resonance imaging documented multiple lesions in the brain and spinal cord.


CONCLUSIONS
Although rarely reported, progression of optic neuropathy over months has been previously documented in Leber hereditary optic neuropathy. The emergence of multiple sclerosis-like symptoms and signs in our patient may be part of the spectrum of Leber hereditary optic neuropathy or a coincidental occurrence.
Tran
M
M
Department of Ophthalmology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Bhargava
R
R
MacDonald
I M
IM
D000328:Adult; D004272:DNA, Mitochondrial / Q000032:analysis; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008928:Mitochondria / Q000235:genetics; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis; D009154:Mutation; D015418:Optic Atrophies, Hereditary / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014786:Vision Disorders / Q000150:complications* / Q000175:diagnosis
D004272:DNA, Mitochondrial