[Post-varicella thrombosis and factor V Leiden mutation].
BACKGROUND
Varicella is a benign infectious disease that is rarely complicated by thrombosis. Factor V Leiden (FVL) mutation is presently recognized as the most common inherited cause of thrombosis. From a case report the link between varicella associated thrombosis and FVL is discussed.


METHODS
An eight year-old boy was admitted on 15th day of a varicella infection for difficulty to walk and painful legs. Doppler ultra sound of the lower limbs venous system showed thrombosis of the left iliac vein and femoral veins. Thrombophilia work-up revealed a FVL heterozygotic status for the patient. Biological screening for molecular abnormalities associated with thrombophilia led to the detection of a heterozygous inherited FVL mutation in the patient. Response to heparine followed by oral anticoagulant treatment was good.


CONCLUSIONS
Thrombosis associated with varicella in child is a rare event. We recommend to realize a thrombophilia screening in such patients. We also support varicella vaccination of children identified as having constitutional prothrombotic disorders like FVL mutation.
Moussalem
M
M
Service de pédiatrie, hématologie-oncologie pédiatrique, hôpital Saint-Georges, BP 166378, Beyrouth 6417, Liban. mirnamou@inco.com.lb
Sacy
R
R
Hakime
N
N
Sfer
N
N
Schvedjf
J F
JF
D002644:Chickenpox / Q000150:complications*; D002648:Child; D005165:Factor V / Q000235:genetics*; D006801:Humans; D008297:Male; D017354:Point Mutation; D013927:Thrombosis / Q000209:etiology*
C095381:factor V Leiden; D005165:Factor V