The long-term antinociceptive effect of intrathecal S(+)-ketamine in a patient with established morphine tolerance.
Our report describes for the first time the continuous long-term intrathecal application of S(+)-ketamine in a patient with chronic pain and morphine tolerance. Intrathecally applied S(+)-ketamine led to a significant pain reduction and consecutively reduced the doses of intrathecal morphine required for pain relief even several weeks after the cessation of the 24-day period of intrathecal S(+)-ketamine administration.
Sator-Katzenschlager
S
S
Department of Anesthesiology and Intensive Care B, University of Vienna, Vienna, Austria. sabine.sator@univie.ac.at
Deusch
E
E
Maier
P
P
Spacek
A
A
Kress
H G
HG
D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000627:therapeutic use*; D001416:Back Pain / Q000188:drug therapy; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D007649:Ketamine / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement
D000700:Analgesics; D000701:Analgesics, Opioid; D000778:Anesthetics, Dissociative; D007649:Ketamine; D009020:Morphine