title: Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population.
abstract: We have searched for genes predisposing to bipolar disorder (BP) by studying individuals with the most extreme form of the affected phenotype, BP-I, ascertained from the genetically isolated population of the Central Valley of Costa Rica (CVCR). The results of a previous linkage analysis on two extended CVCR BP-I pedigrees, CR001 and CR004, and of linkage disequilibrium (LD) analyses of a CVCR population sample of BP-I patients implicated a candidate region on 18p11.3. We further investigated this region by creating a physical map and developing 4 new microsatellite and 26 single-nucleotide polymorphism markers for typing in the pedigree and population samples. We report the results of fine-scale association analyses in the population sample, as well as evaluation of haplotypes in pedigree CR001. Our results suggest a candidate region containing six genes but also highlight the complexities of LD mapping of common disorders.
authors.affiliation: Neurogenetics Laboratory, Center for Neurobiology and Psychiatry, and Department of Psychiatry, University of California, San Francisco, CA 94143, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: McInnes
authors.forename: S K
authors.initials: SK
authors.lastname: Service
authors.forename: V I
authors.initials: VI
authors.lastname: Reus
authors.forename: G
authors.initials: G
authors.lastname: Barnes
authors.forename: O
authors.initials: O
authors.lastname: Charlat
authors.forename: S
authors.initials: S
authors.lastname: Jawahar
authors.forename: S
authors.initials: S
authors.lastname: Lewitzky
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.forename: Q
authors.initials: Q
authors.lastname: Duong
authors.forename: M
authors.initials: M
authors.lastname: Spesny
authors.forename: C
authors.initials: C
authors.lastname: Araya
authors.forename: X
authors.initials: X
authors.lastname: Araya
authors.forename: A
authors.initials: A
authors.lastname: Gallegos
authors.forename: L
authors.initials: L
authors.lastname: Meza
authors.forename: J
authors.initials: J
authors.lastname: Molina
authors.forename: R
authors.initials: R
authors.lastname: Ramirez
authors.forename: R
authors.initials: R
authors.lastname: Mendez
authors.forename: S
authors.initials: S
authors.lastname: Silva
authors.forename: E
authors.initials: E
authors.lastname: Fournier
authors.forename: S L
authors.initials: SL
authors.lastname: Batki
authors.forename: C A
authors.initials: CA
authors.lastname: Mathews
authors.forename: T
authors.initials: T
authors.lastname: Neylan
authors.forename: C E
authors.initials: CE
authors.lastname: Glatt
authors.forename: M A
authors.initials: MA
authors.lastname: Escamilla
authors.forename: D
authors.initials: D
authors.lastname: Luo
authors.forename: P
authors.initials: P
authors.lastname: Gajiwala
authors.forename: T
authors.initials: T
authors.lastname: Song
authors.forename: S
authors.initials: S
authors.lastname: Crook
authors.forename: J B
authors.initials: JB
authors.lastname: Nguyen
authors.forename: E
authors.initials: E
authors.lastname: Roche
authors.forename: J M
authors.initials: JM
authors.lastname: Meyer
authors.forename: P
authors.initials: P
authors.lastname: Leon
authors.forename: L A
authors.initials: LA
authors.lastname: Sandkuijl
authors.forename: N B
authors.initials: NB
authors.lastname: Freimer
authors.forename: H
authors.initials: H
authors.lastname: Chen
mesh_terms: D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D003364:Costa Rica; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D019964:Mood Disorders / Q000235:genetics*; D010375:Pedigree
chemical_list: D005819:Genetic Markers