Decrease in platelet serotonin level in uterine cervix cancer patients.
Platelet serotonin (5-HT) concentration was measured by HPLC with electrochemical detection in 46 women suffering from cancer of the uterine cervix and 16 matched controls. About 53% reduction (p < 0.05) was recorded in platelet 5-HT level in cancer patients against a control value of 1.29 +/- 0.16 (mean +/- S.E.) nmol per 10(9) platelets. Depletion of intraplatelet 5-HT was positively correlated with clinical stage of the disease although a modest rise (p > 0.05) in platelet 5-HT was observed in patients at stage I. Serotonin release from platelets following activation with thrombin was considerably increased in cancer patients (38.2% compared to 17.4% in controls). The results demonstrate progressive depletion of intraplatelet 5-HT in cervical cancer patients. In addition, their platelets release more 5-HT than the controls upon activation by thrombin.
Deb
C
C
Experimental Hematology Unit, Chittaranjan National Cancer Institute, Calcutta, India.
Lakshmi
C
C
Ray
C
C
Ray
M R
MR
D014408:Biomarkers, Tumor / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry* / Q000378:metabolism*; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D012701:Serotonin / Q000097:blood* / Q000378:metabolism; D013917:Thrombin / Q000494:pharmacology; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000175:diagnosis
D014408:Biomarkers, Tumor; D012701:Serotonin; D013917:Thrombin