Effect of prenatal stress on tonic pain in rats.
The effect of prenatal stress on specific biphasic behavioral response in 25-day rat pups was studied using the experimental model of formalin-induced tonic pain. Prenatally stressed rats showed hypersensitivity to tonic nociceptive stimulation manifested in increased amplitude and duration of the response. Behavioral responses observed during the interphase period attest to impairment of inhibitory processes (more pronounced in females). These findings suggest that the interphase interval is the period of active inhibitory process rather than rest period.
Butkevich
I P
IP
Department of Applied Mathematics, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. but@kolt.infran.ru
Vershinina
E A
EA
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D005260:Female; D005557:Formaldehyde / Q000633:toxicity; D008297:Male; D008431:Maternal-Fetal Exchange; D010146:Pain / Q000503:physiopathology; D010147:Pain Measurement; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000151:congenital / Q000503:physiopathology
D005557:Formaldehyde