Chiral separation of pharmacologically active dihydropyrimidinones with carboxymethyl-beta-cyclodextrin.
We report on the chiral separation of pharmacologically active dihydropyrimidinones by capillary electrophoresis (CE) using carboxymethyl-beta-cyclodextrin as chiral selector. The influence of selector concentration, pH, and the addition of varying amounts of methanol is investigated. Out of 21 compounds investigated, 19 were resolved, 13 with baseline separation.
Lecnik
O
O
Institute of Pharmaceutical Chemistry, Karl-Franzens University, Graz, Austria.
Schmid
M G
MG
Kappe
C O
CO
Gübitz
G
G
D003505:Cyclodextrins / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D011744:Pyrimidinones / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D007202:Indicators and Reagents; D011744:Pyrimidinones; D047392:beta-Cyclodextrins; C441457:carboxymethyl-beta-cyclodextrin