SW-163C and E, novel antitumor depsipeptides produced by Streptomyces sp. I. Taxonomy, fermentation, isolation and biological activities.
Novel depsipeptides, SW-163C and E were isolated from the culture broth of an actinomycete strain. The producing organism, designated as SNA15896, was identified as a member of Streptomyces from its morphological and cultural characteristics. SW-163C and E exhibited potent antitumor activities against various tumor cell lines in vitro and against murine leukemia P388 in vivo. The compounds also showed antimicrobial activities.
Kurosawa
K
K
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan. kurosawa@snowbrand.co.jp
Takahashi
K
K
Tsuda
E
E
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D047630:Depsipeptides; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D009368:Neoplasm Transplantation; D010456:Peptides, Cyclic; D013302:Streptomyces / Q000145:classification* / Q000254:growth & development / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000473:pathology
D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; D010456:Peptides, Cyclic; C437363:SW-163C; C437364:SW-163E