title: Decreased HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals on antiretroviral therapy.
abstract: The effect of highly active antiretroviral therapy (HAART) on HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals was studied. Subjects receiving treatment for over a year were compared with individuals not receiving therapy. The absolute number of HIV-specific memory CD4 T cells proliferating in response to HIV antigen was substantially higher in untreated subjects than in those on HAART. A decrease in HIV-specific memory CD4 T cells could explain the rebound in HIV replication after the termination of HAART.
authors.affiliation: BD Biosciences, Immunocytometry Systems, San Jose, CA, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Ghanekar
authors.forename: S A
authors.initials: SA
authors.lastname: Stranford
authors.forename: J C
authors.initials: JC
authors.lastname: Ong
authors.forename: J M
authors.initials: JM
authors.lastname: Walker
authors.forename: V C
authors.initials: VC
authors.lastname: Maino
authors.forename: J A
authors.initials: JA
authors.lastname: Levy
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015488:HIV Antigens / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D015488:HIV Antigens