title: Engineering virtual cardiac tissue.
abstract: The kinetics of proteins involved in ion transfer, sequestration and binding in cardiac cells can be modelled to construct a model of the electrical activity of isolated cardiac cells as a system of ordinary differential equations. These cell models may be incorporated into tissue models, which, when combined with histology and anatomy, form virtual tissues. The effects of changes in specific protein expression, or changes in protein kinetics, produced by mutations or pharmacological agents, can be simulated using these tissue models and used to account for the whole organ effects of changes in specific ion-transport protein activity.
authors.affiliation: School of Biomedical Sciences, Leeds University.
authors.forename: M R
authors.initials: MR
authors.lastname: Boyett
authors.forename: A V
authors.initials: AV
authors.lastname: Holden
authors.forename: H
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000200:Action Potentials; D019295:Computational Biology; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D007700:Kinetics; D008953:Models, Anatomic; D009124:Muscle Proteins / Q000502:physiology; D023822:Tissue Engineering; D014481:United States
chemical_list: D007473:Ion Channels; D009124:Muscle Proteins