Measles virus interactions with cellular receptors: consequences for viral pathogenesis.
Although CNS complications occurring early and late after acute measles are a serious problem and often fatal, the transient immunosuppression lasting for several weeks after the rash is the major cause of measles-related morbidity and mortality worldwide. This review is focused on the interactions of measles virus (MV) with cellular receptors on neural and lymphoid cells which are important elements in viral pathogenesis. First, the cognate MV receptors, CD46 and CD150, are important components of viral tropism by mediating binding and entry. Second, however, additional unknown cellular surface molecules may (independently of viral uptake) after interaction with the MV glycoprotein complex act as signaling molecules and thereby modulate cellular survival, proliferation, and specific functions.
Schneider-Schaulies
J
J
Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany. jss@vim.uni-wuerzburg.de
ter Meulen
V
V
Schneider-Schaulies
S
S
D015703:Antigens, CD / Q000502:physiology*; D000954:Antigens, Surface / Q000502:physiology; D001921:Brain / Q000473:pathology / Q000821:virology; D016207:Cytokines / Q000502:physiology; D018792:Encephalitis, Viral / Q000821:virology; D006023:Glycoproteins / Q000502:physiology*; D006389:Hemagglutinins, Viral / Q000502:physiology; D006801:Humans; D016867:Immunocompromised Host; D007136:Immunoglobulins / Q000502:physiology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D008231:Lymphopenia / Q000150:complications / Q000276:immunology / Q000821:virology; D008459:Measles virus / Q000472:pathogenicity / Q000502:physiology*; D051916:Membrane Cofactor Protein; D008561:Membrane Fusion / Q000502:physiology; D008562:Membrane Glycoproteins / Q000502:physiology*; D008954:Models, Biological; D009457:Neuroglia / Q000821:virology; D009474:Neurons / Q000378:metabolism / Q000821:virology*; D009894:Opportunistic Infections / Q000209:etiology; D011024:Pneumonia, Viral / Q000821:virology; D011956:Receptors, Cell Surface; D011991:Receptors, Virus / Q000502:physiology*; D016192:Resting Phase, Cell Cycle; D015398:Signal Transduction; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology / Q000821:virology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology / Q000821:virology; D014760:Viral Fusion Proteins / Q000502:physiology; D014763:Viral Matrix Proteins / Q000502:physiology; D014766:Viremia / Q000821:virology; D014774:Virulence; D014779:Virus Replication
D015703:Antigens, CD; D000954:Antigens, Surface; C497857:CD46 protein, human; D016207:Cytokines; D006023:Glycoproteins; D006389:Hemagglutinins, Viral; D007136:Immunoglobulins; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C000604059:SLAMF1 protein, human; D014760:Viral Fusion Proteins; D014763:Viral Matrix Proteins; C032397:hemagglutinin protein G, measles virus; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1