HIV pathogenesis and activation of CD4 cells.
Selective upregulation of the transcription of nef and tat genes before integration into the human genome allows HIV to activate CD4 cells and increase viral replication.
Albrecht
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Division of Infectious Diseases, Emory University School of Medicine, Atlanta, USA.
D019380:Anti-HIV Agents / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000821:virology; D015754:Genes, nef; D015756:Genes, tat; D006678:HIV / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D015854:Up-Regulation; D014779:Virus Replication; D015215:Zidovudine / Q000494:pharmacology
D019380:Anti-HIV Agents; D007376:Interleukin-2; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine