Developmental milestones of vertically HIV infected and seroreverters children: follow up of 83 children.
The aim of the study was to detect neurological abnormalities in human immunodeficiency virus (HIV) infected children. This was achieved by a prospective evaluation, from November/1995 to April/2000, of 43 HIV infected children (group I) and 40 HIV seroreverters children (group II) through neurological exam and neurodevelopmental tests: Denver Developmental Screening Test (DDST) and Clinical Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS). A control group (III), of 67 children, were evaluated by CAT/CLAMS. Hyperactivity, irritability and hypotonia were the findings on neurological examination, without statistical differences between group I and II. On CAT/CLAMS, the group I developmental quotient (DQ) was significantly lower than the other groups. The same occurred in DDST, with group I presenting significantly more failures than group II. Nineteen HIV children of group I had brain computed tomographic scan, with abnormalities in three of them (basal ganglia calcification, white matter hypodensity and asymmetry of lateral ventricles). We conclude that in HIV infected children a neurodevelopment delay occur early in the disease, and it can be detected by screening tests.
Bruck
I
I
Centro de Neurologia Pediátrica, Pediatric Department, Clinical Hospital, Federal University of Parana, Curitiba, PR, Brazil.
Tahan
T T
TT
Cruz
C R
CR
Martins
L T
LT
Antoniuk
S A
SA
Rodrigues
M
M
Souza
S M
SM
Bruyn
L R
LR
D002648:Child; D002657:Child Development; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000209:etiology; D016021:Epidemiologic Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000635:transmission; D018023:HIV Seronegativity; D006320:Hearing Tests; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007804:Language Development; D008297:Male; D009483:Neuropsychological Tests; D014057:Tomography, X-Ray Computed