The relative contributions of recombination and point mutation to the diversification of bacterial clones.
Low levels of recombination in bacterial species have often been inferred from the presence of linkage disequilibrium between the alleles at different loci in the population. However, significant linkage disequilibrium is inevitable in organisms that divide by binary fission, and recombinational replacements must be very frequent, compared to point mutation, to dissipate disequilibrium. Recent studies using data from multilocus sequence typing indicate that, in many species, recombinational replacements contribute more greatly to clonal diversification than do point mutations and, in some species, recombination has been sufficient to eliminate any phylogenetic signal from gene trees. Recent efforts to improve understanding of the extent and impact of homologous recombination in the diversification of bacterial clones are discussed.
Spratt
B G
BG
Department of Infectious Disease Epidemiology, Imperial College School of Medicine, St. Mary's Hospital, London W2 1PG, UK. b.spratt@ic.ac.uk
Hanage
W P
WP
Feil
E J
EJ
D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D017354:Point Mutation; D011995:Recombination, Genetic