Protective role of Delphinium denudatum (Jadwar) against morphine induced tolerance and dependence in mice.
Chronic treatment with Delphinium denudatum (Dd) (Jadwar) (family: Ranunculaceae, 200-1600 mg/kg) suppressed morphine withdrawal jumps in a dose-dependent manner, a sign of the development of dependence to opiate as assessed by naloxone (2 mg/kg) precipitation withdrawal on day 10 of testing in mice. Repeated administration of Dd (200-1600 mg/kg) for 9 days attenuated the development of tolerance to the analgesic effect of morphine (10 mg/kg), also produces significant change in tail-flick latency from the saline pretreated group in a dose-dependent manner.
Zafar
S
S
Department of Ilmul Advia (Pharmacology), Faculty of Medicine (Unani), Hamdard University, Hamdard Nagar, 110062, New Delhi, India. shadabzafar@rediffmail.com
Ahmad
M A
MA
Siddiqui
T A
TA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004361:Drug Tolerance; D005260:Female; D008297:Male; D051379:Mice; D009021:Morphine Dependence / Q000188:drug therapy*; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D029626:Ranunculaceae / Q000737:chemistry*
D009292:Narcotic Antagonists; D010936:Plant Extracts; D009270:Naloxone