title: Novel syntheses of 2,3-dihydro-1,5-benzothiazepin-4(5h)-ones and 2h-1,4-benzothiazin-3(4h)-ones.
abstract: Nucleophilic additions of alpha-mercaptoalkanoate esters and beta-mercaptoalkanoate acids to benzoquinone diimines, followed by cyclization with trifluoroacetic acid or 1,3-dicyclohexylcarbodiimide (DCC), provide novel, high-yielding syntheses of 2H-1,4-benzothiazin-3(4H)-ones (3a-f) and 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones (5a-c), respectively.
authors.affiliation: Flexsys America L. P., 260 Springside Drive, Akron, Ohio 44333, USA. katritzky@chem.ufl.edu
authors.forename: A R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: H H
authors.initials: HH
authors.lastname: Odens
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: C J
authors.initials: CJ
authors.lastname: Rostek
authors.forename: O W
authors.initials: OW
authors.lastname: Maender
mesh_terms: D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013841:Thiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002121:Calcium Channel Blockers; D013841:Thiazepines; D013843:Thiazines