Inhibitory effects of capsaicinoids on fatty acid desaturation in a rat liver cell line.
The inhibitory effects of such vanillylamides as capsaicin and nine capsaicinoids on fatty acid desaturation in liver cells were investigated by using the cultured rat liver cell line, BRL-3A. When capsaicin was added to the medium, it had a relatively strong inhibitory effect on delta6 desaturation and clear inhibitory effects on delta5 and C24delta16 desaturation (delta16 desaturation of C24-polyunsaturated fatty acids). Capsaicinoids with side carbon chain lengths of C10:0 and C12:0 expressed the maximum inhibitory effects of the nine capsaicinoids on fatty acid desaturation in the BRL-3A cells. The inhibitory effects of the capsaicinoids were not correlated with their pungency.
Nakano
N
N
Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University, Nara, Japan.
Shirasaka
N
N
Masuoka
K
K
Murakami
T
T
Watanabe
T
T
Kobata
K
K
Shimizu
S
S
Yoshizumi
H
H
D000818:Animals; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002212:Capsicum / Q000737:chemistry*; D002460:Cell Line; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
D005231:Fatty Acids, Unsaturated; D002211:Capsaicin