Synthesis and characterisation of a new amphotericin B-methoxypoly(ethylene glycol) conjugate.
The reaction of methoxypoly(ethylene glycol)-4-nitrophenyl carbonate with amphotericin B has been used to prepare a new conjugate of amphotericin B (mPEG-AmB). A preliminary screening of in vitro antifungal activity has suggested that mPEG-AmB possesses a similar effect and a similar spectrum of activity as the conventional amphotericin B formulated with sodium desoxycholate.
Sedlák
M
M
Department of Organic Chemistry, University of Pardubice, Cs. legií 565, 532 10 Pardubice, Czech Republic. sedlak@upce.cz
Buchta
V
V
Kubicová
L
L
Simůnek
P
P
Holcapek
M
M
Kasparová
P
P
D000666:Amphotericin B / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
D000935:Antifungal Agents; D011092:Polyethylene Glycols; D000666:Amphotericin B; C028210:monomethoxypolyethylene glycol