Significant overexpression of oligophrenin-1 in colorectal tumors detected by cDNA microarray analysis.
The human oligophrenin-1 gene is ubiquitously expressed at low levels and expressed at high levels in the developing neuroepithelium of the neural tube. Mutations in this gene have been related to the X-linked mental retardation. Using cDNA microarrays, we found evidence that oligophrenin-1 is strongly up-regulated in colorectal tumors. Semiquantitative reverse transcriptase polymerase chain reaction confirmed this finding. Thus, a well-known nervous system-associated human gene transcript may also be an important colorectal tumor marker and potential therapeutic target.
Pinheiro
N A
NA
Department of Biochemistry, Instituto de Química, University of São Paulo, São Paulo, Brazil.
Caballero
O L
OL
Soares
F
F
Reis
L F
LF
Simpson
A J
AJ
D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism*; D003598:Cytoskeletal Proteins; D018076:DNA, Complementary / Q000378:metabolism*; D020690:GTPase-Activating Proteins; D006801:Humans; D009154:Mutation; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010750:Phosphoproteins / Q000096:biosynthesis* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015854:Up-Regulation
D014408:Biomarkers, Tumor; D003598:Cytoskeletal Proteins; D018076:DNA, Complementary; D020690:GTPase-Activating Proteins; D009687:Nuclear Proteins; C111952:OPHN1 protein, human; D010750:Phosphoproteins