title: A novel one-pot pyrrole synthesis via a coupling-isomerization-Stetter-Paal-Knorr sequence.
abstract: [reaction: see text]. 1,2,3,5-tetrasubstituted pyrroles can be synthesized in good yields in a one-pot, three-step, four-component process by a coupling-isomerization-Stetter reaction-Paal-Knorr sequence of an electron-poor (hetero)aryl halide, a terminal propargyl alcohol, an aldehyde, and a primary amine. The structures of the 1,4-diketone 4f and the pyrrole 6b were additionally supported by X-ray structure analyses.
authors.affiliation: Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13 (Haus F), D-81377 München, Germany.
authors.forename: R U
authors.initials: RU
authors.lastname: Braun
authors.forename: K
authors.initials: K
authors.lastname: Zeitler
authors.forename: T J
authors.initials: TJ
authors.lastname: Müller
mesh_terms: D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D007536:Isomerism; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis*
chemical_list: D011758:Pyrroles