title: [HTLV-I/II seroprevalence and risk factors associated with infection in a blood donor population in Córdoba, Argentina].
abstract: In this study we have determined the seroprevalence of infections by HTLV-I/II in the blood donor population from the city of Córdoba. A total of 5476 blood donor sera were screened for HTLV-I/II antibodies by particle agglutination assay (PA) (SERODIA HTLV-I, Fujirebio INC, Tokyo, Japan). The reactive sera samples were confirmed by an "in house" indirect immunofluorescence assay (IFA). 14 out of 5476 blood donors studied were PA reactive and were confirmed positive by IFA, showing a prevalence of 0.26% (95% confidence interval: 0.126%-0.394%). All the positive samples, except one, met the criteria for HTLV-I. Although one HTLV-I infected donor was an intravenous drug abuser and two donors were born in highly endemic areas for HTLV-I, no specific risk factors were identified among the others. The demonstration that HTLV-I circulates in blood donor population of Córdoba, points out that the systematic screening of blood for HTLV-I/II antibodies must be implemented in the blood banks, in an attempt to prevent the spread of infections with this oncogenic virus in Argentina.
authors.affiliation: Instituto de Virología Dr. J.M. Vanella, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina. sgallego@cmefcm.uncor.edu
authors.forename: S
authors.initials: S
authors.lastname: Gallego
authors.forename: E
authors.initials: E
authors.lastname: Maturano
authors.forename: A
authors.initials: A
authors.lastname: Recalde
authors.forename: R
authors.initials: R
authors.lastname: Gastaldello
authors.forename: S
authors.initials: S
authors.lastname: Sileoni
authors.forename: H
authors.initials: H
authors.lastname: Bepre
authors.forename: S
authors.initials: S
authors.lastname: Medeot
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001118:Argentina; D001782:Blood Donors; D001803:Blood Transfusion / Q000706:statistics & numerical data; D015897:Comorbidity; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood*; D015490:HTLV-I Infections / Q000453:epidemiology*; D015482:HTLV-II Antibodies / Q000097:blood*; D015491:HTLV-II Infections / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D015819:Substance Abuse, Intravenous / Q000453:epidemiology; D065227:Transfusion Reaction
chemical_list: D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies