title: Compressive optic neuropathy caused by renal osteodystrophy. Case report.
abstract: Compressive optic neuropathy with acute or chronic vision loss has been associated with various skull base tumors, aneurysms, Graves disease, trauma, and, less commonly, fibrous dysplasia and osteopetrosis. The authors present a case of acute visual deterioration in a 25-year-old woman who had massive calvarial hypertrophy with optic canal stenosis secondary to renal osteodystrophy (uremic leontiasis ossea [ULO]: bighead disease). Significant visual field restoration was achieved with high-dose corticosteroids followed by optic nerve decompression. This is the first case report of cranial neuropathy associated with ULO.
authors.affiliation: Department of Neurology, University of Utah Health Sciences Center, Salt Lake City 84132, USA. rhs@suzy.med.utah.edu
authors.forename: R H
authors.initials: RH
authors.lastname: Schmidt
authors.forename: L A
authors.initials: LA
authors.lastname: Rietz
authors.forename: B C
authors.initials: BC
authors.lastname: Patel
authors.forename: A G
authors.initials: AG
authors.lastname: Osborne
authors.forename: D
authors.initials: D
authors.lastname: Pratt
authors.forename: K B
authors.initials: KB
authors.lastname: Digre
mesh_terms: D000328:Adult; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D019299:Decompression, Surgical; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000627:therapeutic use; D009901:Optic Nerve Diseases / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D012607:Scotoma / Q000209:etiology / Q000503:physiopathology; D012886:Skull / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014794:Visual Fields
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone