Reproductive outcome in patients with diminished ovarian reserve.
OBJECTIVE
To compare reproductive outcome between women with normal ovarian reserve and women with abnormal ovarian reserve.


METHODS
Retrospective.


METHODS
Tertiary care center.


METHODS
Nine thousand eight hundred and two patients who had basal follicle-stimulating hormone (FSH) concentrations measured as part of an infertility evaluation.


METHODS
Monitoring of early pregnancy.


METHODS
Pregnancy loss rates, live birth rates.


RESULTS
Of 1,034 patients with diminished ovarian reserve (DOR) (FSH > or =14.2 IU/L), 28 (2.7%) conceived. Twenty of these pregnancies (20/28; 71.4%) were lost in the first trimester. Pregnancy loss rates in women with DOR were 57.1% in women <35 years old, 63.5% in women 35-40 years old, and 90.0% in women >40 years old. These rates of pregnancy loss were significantly higher compared to age-matched patients with normal ovarian reserve.


CONCLUSIONS
Women with DOR have exceedingly high rates of pregnancy loss, regardless of age. Women with diminished ovarian reserve should be counseled that, in addition to a low probability of conception, live birth rates are poor.
Levi
A J
AJ
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Raynault
M F
MF
Bergh
P A
PA
Drews
M R
MR
Miller
B T
BT
Scott
R T
RT
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D001723:Birth Rate; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000503:physiopathology*; D009515:New Jersey; D010053:Ovary / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011261:Pregnancy Trimester, First; D012098:Reproduction; D012189:Retrospective Studies
D005640:Follicle Stimulating Hormone