title: Symptoms and neurophysiological picture of carpal tunnel syndrome in pregnancy.
abstract: OBJECTIVE
  To evaluate the incidence of carpal tunnel syndrome (CTS) in pregnancy through a validated and multiperspective assessment of CTS.
  
  
  METHODS
  During 2000, the Italian CTS study group focussed on the occurrence of CTS in women during the final stages of pregnancy, enrolled in 7 Italian centers. In addition to the physician-centered and neurophysiologic traditional evaluations, we used a validated patient-oriented measurement to obtain more comprehensive and consistent data for severity of symptoms and functional impairment.
  
  
  RESULTS
  In our study, CTS was clinically diagnosed in more than half of women (62%). Neurophysiological evaluation provided diagnosis of CTS in around half of women (43% were positive in one hand at least). Our study provides evidence, reported here for the first time, of a correlation between edema and neurophysiological picture. Similarly, our study provides a correlation between validated patient-oriented measurement and edema. Moreover, a significant correlation between a negative trend (subjectively assessed) and smoking and alcohol consumption was observed.
  
  
  CONCLUSIONS
  Our observations confirm that the edema of the tissues in the carpal tunnel could induce a mechanical compression of the nerve. Moreover, our data suggest that smoking and alcohol consumption have a negative role in the evolution of the syndrome probably due to impairment of the microcirculation.
authors.affiliation: Institute of Neurology, Università Cattolica, Largo A. Gamelli 8, 00168, Rome, Italy. lpadua@mclink.it
authors.forename: L
authors.initials: L
authors.lastname: Padua
authors.forename: I
authors.initials: I
authors.lastname: Aprile
authors.forename: P
authors.initials: P
authors.lastname: Caliandro
authors.forename: T
authors.initials: T
authors.lastname: Carboni
authors.forename: A
authors.initials: A
authors.lastname: Meloni
authors.forename: S
authors.initials: S
authors.lastname: Massi
authors.forename: O
authors.initials: O
authors.lastname: Mazza
authors.forename: M
authors.initials: M
authors.lastname: Mondelli
authors.forename: A
authors.initials: A
authors.lastname: Morini
authors.forename: D
authors.initials: D
authors.lastname: Murasecco
authors.forename: M
authors.initials: M
authors.lastname: Romano
authors.forename: P
authors.initials: P
authors.lastname: Tonali
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001794:Blood Pressure / Q000502:physiology; D002349:Carpal Tunnel Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D004487:Edema / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008833:Microcirculation / Q000503:physiopathology; D010298:Parity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011263:Pregnancy Trimester, Third; D015203:Reproducibility of Results; D012907:Smoking; D011795:Surveys and Questionnaires; D015430:Weight Gain