Severe oral mucositis after therapeutic administration of [131I]MIBG in a child with neuroblastoma.
OBJECTIVE
The purpose of this report is to document a newly encountered oral side effect of targeted radiotherapy with iodine 131-metaiodobenzylguanidine ([(131)I]MIBG) in the treatment of neuroblastoma.


METHODS
A 14-month-old girl was diagnosed with stage 4 neuroblastoma. After completion of chemotherapy, the tumor showed no signs of regression; treatment with 3700 MBq [(131)I]MIBG was therefore decided on, 8 months after diagnosis.


RESULTS
Fourteen days after infusion of MIBG, severe oral mucositis was diagnosed, with a generalized erythema involving the mucous membranes of the hard and soft palate, buccal mucosa, and upper and lower lips. The gingiva exhibited a general linear erythema.


CONCLUSIONS
Visualization of the salivary glands on [(123)I]MIBG images suggests that accumulation of radiolabeled MIBG in the salivary glands may be related to sympathetic innervation.
Dahllöf
G
G
Department of Pediatric Dentistry, School of Dentistry, Karolinska Institutet, Huddinge, Sweden.
Borgström
P
P
Lundell
G
G
Jacobsson
H
H
Kogner
P
P
D019797:3-Iodobenzylguanidine / Q000009:adverse effects* / Q000627:therapeutic use; D000008:Abdominal Neoplasms / Q000532:radiotherapy*; D004890:Erythema / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D009061:Mouth Mucosa / Q000528:radiation effects*; D009447:Neuroblastoma / Q000532:radiotherapy*; D013280:Stomatitis / Q000209:etiology*
D019797:3-Iodobenzylguanidine