Potent, low molecular weight thrombin receptor antagonists.
Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC(50) of 33 nM.
Chackalamannil
S
S
Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA. samuel.chackalamannil@spcorp.com
Doller
D
D
Eagen
K
K
Czarniecki
M
M
Ahn
H S
HS
Foster
C J
CJ
Boykow
G
G
D008970:Molecular Weight; D018179:Receptors, Thrombin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D018179:Receptors, Thrombin