[Effect of chronic craving for ethanol on accumulation of calcium ions in intracellular structures of rat myometrium].
In the experiments on the impregnant estrogenized rats the effect of chronic ethanol intake on Ca(2+)-accumulative mitochondrial systems and endoplasmatic systems of myometrium was estimated. It was defined that in chronic alcohol consumption the transport activity of mitochondria Ca(2+)-accumulative systems didn't prevail over endoplasmatic reticulum Ca(2+)-accumulative activity. Therewith mitochondria and endoplasmatic Ca(2+)-transport system was essentially disturbed. In the tested conditions Mg2+, ATP-dependent sensitivity of calcium pump to oxytocin inhibiting action was shown to disappear.
Borisova
L A
LA
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv. LBorisova@biochem.kiev.ua
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D007700:Kinetics; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D009042:Motivation; D009215:Myometrium / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats
D000431:Ethanol; D000255:Adenosine Triphosphate; D000252:Calcium-Transporting ATPases; D002118:Calcium