title: Clocapramine-related fatality. Postmortem drug levels in multiple psychoactive drug poisoning.
abstract: A suicide caused by ingestion of multiple psychoactive drugs is reported. A 42-year-old man with a history of psychosis was found dead in a blood pool in his room. The forensic autopsy revealed two stab wounds on his chest. However, these wounds could not explain the cause of death. Eighty-six tablets were found in his stomach. Four psychoactive drugs; clocapramine (CC), chlorpromazine (CP), promethazine (PM) and clotiazepam (CT) were detected in blood and tissues. The concentrations of CC, CP, PM and CT in the femoral vein (FV) blood were 0.39, 0.61, 1.23 and 0.09 microg/ml, respectively. The cause and manner of death were attributed to suicidal multiple psychoactive drug poisoning. Postmortem drug redistribution showed great site-dependent variations with the lowest level in the FV blood. Remarkable variations were observed in CC, CP and PM, but not in CT compared to other three drugs. The variations were dependent on the volume of distribution (Vd) of the drugs. Our human case has demonstrated drugs with higher Vd values showed higher degree of postmortem redistribution of the drug and vice versa.
authors.affiliation: Department of Forensic Medicine, Kumamoto University School of Medicine, 2-2-1 Honjyo, 860-0811, Kumamoto, Japan. ako@medic.kumamoto-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Koreeda
authors.forename: K
authors.initials: K
authors.lastname: Yonemitsu
authors.forename: P M
authors.initials: PM
authors.lastname: Ng'walali
authors.forename: N
authors.initials: N
authors.lastname: Muraoka
authors.forename: S
authors.initials: S
authors.lastname: Tsunenari
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003984:Dibenzazepines / Q000506:poisoning*; D006801:Humans; D008297:Male; D011619:Psychotropic Drugs / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D013405:Suicide; D014018:Tissue Distribution
chemical_list: D003984:Dibenzazepines; D011619:Psychotropic Drugs; C000449:3-chlorocarpipramine