title: Environmental gram-positive mastitis treatment: in vitro sensitivity and bacteriologic cure.
abstract: A clinical trial was conducted in a large dairy herd to determine the efficacy of intramammary pirlimycin hydrochloride administration during lactation for bacteriologic clearance of gram-positive environmental clinical and subclinical mastitis infections. Quarters infected with environmental streptococci that received pirlimycin therapy (13/28) were 1.8 times more likely to resolve infection than untreated quarters (5/14). The small numbers of quarters infected with coagulase-negative staphylococci resulted in inadequate power to assess treatment differences in cure rate. Although the association was not statistically significant, quarters from cows with sensitive environmental streptococci isolates from composite samples (8/13) resolved infection with treatment at approximately twice the rate of treated quarters with resistant isolates (3/10).
authors.affiliation: Department of Clinical Sciences, Colorado State Univeristy, Fort Collins 80525, USA. mcattell@aol.com
authors.forename: M B
authors.initials: MB
authors.lastname: Cattell
authors.forename: R P
authors.initials: RP
authors.lastname: Dinsmore
authors.forename: A P
authors.initials: AP
authors.lastname: Belschner
authors.forename: J
authors.initials: J
authors.lastname: Carmen
authors.forename: G
authors.initials: G
authors.lastname: Goodell
mesh_terms: D000818:Animals; D002417:Cattle; D002981:Clindamycin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D008892:Milk / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000662:veterinary*; D013210:Staphylococcus / Q000187:drug effects; D013290:Streptococcal Infections / Q000188:drug therapy / Q000662:veterinary*; D013291:Streptococcus / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002981:Clindamycin; C034093:pirlimycin