title: Reprogramming somatic cell differentiation and the Hayflick Limit: contrasting two modern molecular bioengineering aims and their impact on the future of mankind.
abstract: The molecular biology of human cloning and aging research depend on the closely related laboratory techniques supported by a thorough understanding of cell-signaling processes. Unfortunately, the link between these two research fields has received only marginal attention in the lay press. Cloning is possible when somatic cell differentiation is successfully reprogrammed, and clinical control of cellular senescence depends on a proper reconfiguration of the predetermined number of divisions permitted during the cell life-cycle (the so-called "Hayflick Limit"). In this paper, we discuss these two concepts and compare the impact likely to be associated with bioengineering studies that facilitate both human cloning and longevity therapy.
authors.affiliation: Georgia Reproductive Specialists LLC, Atlanta, Georgia, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Sills
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Z
authors.initials: Z
authors.lastname: Rosenwaks
authors.forename: G D
authors.initials: GD
authors.lastname: Palermo
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation; D019976:Cloning, Organism; D004989:Ethics; D006801:Humans; D012098:Reproduction; D014430:Twins, Monozygotic