title: Correlation between 99mTc-pertechnetate uptakes and expressions of human sodium iodide symporter gene in breast tumor tissues.
abstract: We investigated a correlation between the expression of human sodium iodide symporter (hNIS) mRNA and the uptake of 99mTc-pertechnetate in 25 breast tumors. 99mTc-pertechnetate scintigraphy revealed positive uptake in 4 patients. The normalized mRNA expression of hNIS was higher in tumors with positive uptake on the scintigraphy (n=4, median 0.97, range 0.78-1.27) than that in negative uptake tumors (n=21, median 0.46, range 0.10-1.03, p < 0.005). 99mTc-pertechnetate uptake is correlated with the hNIS expression in the breast tumor.
authors.affiliation: Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. dhmoon@amc.seoul.kr
authors.forename: D H
authors.initials: DH
authors.lastname: Moon
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: K Y
authors.initials: KY
authors.lastname: Park
authors.forename: K K
authors.initials: KK
authors.lastname: Park
authors.forename: S H
authors.initials: SH
authors.lastname: Ahn
authors.forename: M S
authors.initials: MS
authors.lastname: Pai
authors.forename: H
authors.initials: H
authors.lastname: Chang
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
authors.forename: I M
authors.initials: IM
authors.lastname: Ahn
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D027981:Symporters / Q000096:biosynthesis / Q000378:metabolism*; D000099209:Sodium-Iodide Symporters
chemical_list: D012333:RNA, Messenger; D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m; D027981:Symporters; D000099209:Sodium-Iodide Symporters