title: Focal pulmonary uptake during Tc-99m myocardial perfusion SPECT imaging.
abstract: OBJECTIVE
  To evaluate the incidence and origin of abnormal focal pulmonary uptake during myocardial perfusion SPECT imaging (MSPECT).
  
  
  METHODS
  For evaluation of chest pain, 790 men and 581 women (mean age, 56 +/- 13 years) underwent MSPECT. All of them received adenosine for pharmacologic stress and Tc-99m tetrofosmin (TF, n = 817) or Tc-99m sestamibi (MIBI, n = 554) for myocardial perfusion imaging.
  
  
  RESULTS
  Review of chest radiography with or without computed tomography revealed 111 (8.1%) focal pulmonary diseases. Among them, 38 (34.2%) showed focal pulmonary uptake (TF, 22; MIBI, 16); 27 (30.7%) of 88 showed previous pulmonary tuberculosis; 2 of 10 (20%) benign pulmonary nodules; 4 of 5 (80%) metastatic lung cancers; 2 of 4 (50%) primary lung cancers; and 3 of 4 (75%) pneumonias. No difference in uptake was noted for the two imaging agents. Intensity of uptake did not vary with origin of the uptake. Focal abnormal pulmonary uptake was found in 2.8% of patients undergoing MSPECT and in 34.2% of patients in whom radiological examinations showed regional pulmonary disease. In patients with abnormal pulmonary uptake on MSPECT, 16% had a malignant lesion, whereas 75% of patients with a pulmonary nodule shown on radiography and focal pulmonary uptake on MSPECT had a malignant lesion.
  
  
  CONCLUSIONS
  Although the incidence of abnormal pulmonary uptake during MSPECT was very low, the incidence of malignant lesions in the patients with nodular pulmonary uptake was relatively high.
authors.affiliation: Department of Nuclear Medicine and Research Institute of Medical Sciences, Chonnam National University Medical School, Kwangju, Korea.
authors.forename: S M
authors.initials: SM
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Bom
authors.forename: H C
authors.initials: HC
authors.lastname: Song
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeong
authors.forename: J J
authors.initials: JJ
authors.lastname: Min
authors.forename: M H
authors.initials: MH
authors.lastname: Li
authors.forename: J T
authors.initials: JT
authors.lastname: Lee
authors.forename: S T
authors.initials: ST
authors.lastname: Lim
authors.forename: J Y
authors.initials: JY
authors.lastname: Kim
mesh_terms: D000241:Adenosine; D000368:Aged; D002637:Chest Pain / Q000000981:diagnostic imaging; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008171:Lung Diseases / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents
chemical_list: D019275:Radiopharmaceuticals; D014665:Vasodilator Agents; D017256:Technetium Tc 99m Sestamibi; D000241:Adenosine