title: Intravascular ultrasound analysis of beta radiation therapy for diffuse in-stent restenosis to inhibit intimal hyperplasia.
abstract: We evaluated the efficacy of beta-radiation therapy ((188)Re-MAG(3)) to inhibit intimal hyperplasia (IH) in diffuse in-stent restenosis by intravascular ultrasound (IVUS) analysis in 50 patients. Nine patients who did not agree with radiation therapy, and therefore underwent rotational atherectomy and balloon angioplasty for diffuse in-stent restenosis in the same study period, were selected for control groups. Serial IVUS comparisons were available in 44 of 50 patients with radiation therapy and 7 of 9 control patients. At 6-month follow-up, there was less significant increase of IH area in patients with radiation therapy than in control patients (Delta IH area = 0.1 +/- 0.8 mm(2) vs. 2.6 +/- 1.8 mm(2), P > 0.001 in mean values, and 0.6 +/- 1.4 mm(2) vs. 2.9 +/- 2.1 mm(2), P = 0.026 in values of follow-up lesion site, respectively). In conclusion, beta-radiation therapy might be an effective treatment modality to inhibit intimal hyperplasia in patients with diffuse in-stent restenosis.
authors.affiliation: Department of Medicine, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, South Korea.
authors.forename: M K
authors.initials: MK
authors.lastname: Hong
authors.forename: S W
authors.initials: SW
authors.lastname: Park
authors.forename: D H
authors.initials: DH
authors.lastname: Moon
authors.forename: S J
authors.initials: SJ
authors.lastname: Oh
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.forename: K S
authors.initials: KS
authors.lastname: Rhee
authors.forename: F
authors.initials: F
authors.lastname: Sun
authors.forename: J M
authors.initials: JM
authors.lastname: Song
authors.forename: D H
authors.initials: DH
authors.lastname: Kang
authors.forename: J K
authors.initials: JK
authors.lastname: Song
authors.forename: J J
authors.initials: JJ
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Park
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017225:Atherectomy, Coronary; D001610:Beta Particles / Q000627:therapeutic use; D017023:Coronary Angiography; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging* / Q000628:therapy*; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D017539:Tunica Intima / Q000000981:diagnostic imaging* / Q000473:pathology*; D018084:Ultrasonography, Interventional