Synthesis and biological activity of 2-thiono-[1H]-5-spirocyclohexylimidazo[4,3-b]quinazolone and 8-azaquinazolone derivatives.
The reaction of 5-spirocyclohexylimidazole-2,4-dithion with one and two mole equivalent of b-aminocarboxylic acid derivatives (2a-b and 5) to give new heterocyclic systems of synthetic and potential biological interest viz. compounds (3a-b, 4a-b, 6 and 7). The structures of the products have established by chemical and spectroscopic evidence. The antimicrobial activity of the synthesized compounds was tested against 10 bacterial and yeast strains.
Hamad
A S
AS
Department of Chemistry, Faculty of Science, University of Ain Shams, Cairo, Egypt.
Azab
M E
ME
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*
C437285:2-thiono(1H)-5-spirocyclohexylimidazo(4,3-b)quinazolone; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011799:Quinazolines