The dual role of CTLA-4 in Leishmania infection.
The role of CTLA-4 in inducing the production of transforming growth factor beta (TGF-beta) from T cells during a Leishmania infection has only recently been recognized. However, CTLA-4 and TGF-beta affect T helper cells differently, depending on the maturation. This review discusses the data obtained from different experimental models and demonstrates that CTLA-4 is a target molecule for vaccination and therapy against leishmaniasis.
Gomes
N A
NA
Oswaldo Cruz Institute, FIOCRUZ, Av. Brasil, 4365, Rio de Janeiro, RJ 21045-900, Brazil.
DosReis
G A
GA
D000069594:Abatacept; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000502:physiology*; D060908:CTLA-4 Antigen; D006801:Humans; D018796:Immunoconjugates; D007891:Leishmania / Q000472:pathogenicity* / Q000502:physiology; D007896:Leishmaniasis / Q000276:immunology / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000378:metabolism
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C556707:Ctla4 protein, mouse; D018796:Immunoconjugates; D016212:Transforming Growth Factor beta; D000069594:Abatacept