title: Loss of KAI1/CD82 expression in bone and soft tissue tumors is not associated with lung metastasis.
abstract: The KAI1 gene has been identified as a metastasis suppressor gene in human prostate cancer. Decrease or loss of KAI1/CD82 expression has been shown to be associated with poorer prognosis and metastasis in carcinomas of various organs. The purpose of this study was to examine whether KAI1/CD82 is expressed in bone and soft tissue tumors, and whether it is associated with metastasis to the lungs. Immunohistochemically, KAI1/CD82 expression in benign and malignant soft tissue tumors was noted in 83% and 37% of cases, respectively. KAI1/CD82 was- also expressed in benign bone tumors and osteosarcomas in 67% and 36% of the cases, respectively. Four (40%) of 10 osteosarcoma cases with no lung metastasis and one (25%) of four osteosarcoma cases with lung metastasis were positive for KAI1/CD82, respectively. Metastasis of osteosarcoma cells to the lungs was not correlated with the loss of KAI1/CD82 in osteosarcoma cells.
authors.affiliation: Second Department of Pathology, Hiroshima University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Arihiro
authors.forename: K
authors.initials: K
authors.lastname: Inai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD; D000954:Antigens, Surface / Q000032:analysis / Q000378:metabolism*; D015153:Blotting, Western; D001859:Bone Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D007223:Infant; D051861:Kangai-1 Protein; D008175:Lung Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000556:secondary; D008562:Membrane Glycoproteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015345:Oligonucleotide Probes / Q000737:chemistry; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000032:analysis; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D000954:Antigens, Surface; C497688:CD82 protein, human; D051861:Kangai-1 Protein; D008562:Membrane Glycoproteins; D015345:Oligonucleotide Probes; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm