title: Intramolecular Mannich reaction in the asymmetric synthesis of polysubstituted piperidines: concise synthesis of the dendrobate alkaloid (+)-241D and its C-4 epimer.
abstract: [reaction: see text] The intramolecular Mannich reaction of delta-amino beta-keto esters with aldehydes and ketones is a new methodology for the synthesis of polysubstituted piperidines and is illustrated by the concise asymmetric synthesis of the dendrobate alkaloid (+)-241D and its C-4 epimer.
authors.affiliation: Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA. fdavis@astro.ocis.temple.edu
authors.forename: F A
authors.initials: FA
authors.lastname: Davis
authors.forename: B
authors.initials: B
authors.lastname: Chao
authors.forename: A
authors.initials: A
authors.lastname: Rao
mesh_terms: D010880:Piperidines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: C413204:241D dendrobate alkaloid; D010880:Piperidines