title: Concurrent angiomyolipomas and renal cell carcinoma harboring metastatic foci of mammary carcinoma in the same kidney: an incidental autopsy finding in a patient with a follow-up of thirty years.
abstract: The synchronous occurrence of three different types of renal tumor in a patient is rare. We report a case of conventional (clear cell) renal cell carcinoma harboring metastatic foci of mammary carcinoma associated with two angiomyolipomas in the left kidney incidentally discovered at the autopsy. The patient was a 75-year-old woman, without the tuberous sclerosis complex, who had undergone left radical mastectomy and radiotherapy for an infiltrating duct carcinoma of breast 30 years before. This tumor was widely disseminated at autopsy, but the nontumorous renal parenchyma was free of metastases. To the best of our knowledge this combination of neoplasms has not been described before. This case shows the important role played by autopsy in the accurate investigation of interrelations among coexisting tumors.
authors.affiliation: Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, University of Cantabria, Avda. Valdecilla 1, E-39008 Santander, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Val-Bernal
authors.forename: F
authors.initials: F
authors.lastname: Villoria
authors.forename: M A
authors.initials: MA
authors.lastname: Pérez-Expósito
mesh_terms: D000368:Aged; D000782:Aneuploidy; D018207:Angiomyolipoma / Q000235:genetics / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000556:secondary* / Q000601:surgery; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000556:secondary*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D015674:Mammary Neoplasms, Animal / Q000473:pathology* / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm