title: Time for T.
abstract: Genetic defects responsible for cleft lip and cleft palate are only now beginning to be uncovered. Mutations in the gene encoding a T-box transcription factor have been identified as the cause of the rare X-linked syndrome cleft palate with tongue-tie. And in another study, heterozygotes for a defective allele for a cell adhesion molecule, which is responsible for a rare clefting syndrome when homozygous, have been found at higher than expected incidence in sporadic forms of clefting.
authors.forename: J C
authors.initials: JC
authors.lastname: Murray
mesh_terms: D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D008040:Genetic Linkage; D006330:Heart Defects, Congenital / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009154:Mutation; D020825:T-Box Domain Proteins / Q000502:physiology*; D014960:X Chromosome
chemical_list: D020825:T-Box Domain Proteins