Optical resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline by supercritical fluid extraction.
6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) enantiomers were separated by supercritical fluid extraction using carbon dioxide. Diastereoisomeric salts were formed from the racemic base with less than one equivalent of O,O'-di-(4-toluoyl)-(2R,3R)-tartaric acid (DPTTA). Further purification was achieved by partial salt formation of the enantiomeric mixture with an achiral acid (HCl) followed by the supercritical fluid extraction of the free enantiomers.
Kmecz
I
I
Budapest University of Technology and Economics, Department of Chemical Engineering, Budapest, Hungary.
Simándi
B
B
Bálint
J
J
Székely
E
E
Fogassy
E
E
Kemény
S
S
D000890:Anti-Infective Agents / Q000302:isolation & purification*; D002245:Carbon Dioxide / Q000737:chemistry; D007202:Indicators and Reagents; D011804:Quinolines / Q000302:isolation & purification*; D013237:Stereoisomerism; D013696:Temperature
C440210:6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline; D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D011804:Quinolines; D002245:Carbon Dioxide