title: Evaluation of the gamma-synuclein gene in German Parkinson's disease patients.
abstract: Mutations in the alpha-synuclein gene are responsible for an autosomal-dominantly inherited form of Parkinson's disease (PD) and alpha-synuclein was found to be the major component of Lewy bodies in PD. Because of the high homology to alpha-synuclein and the abundance in neuronal tissues, we investigated the gamma-synuclein gene in PD. We analyzed 262 German PD patients and 179 healthy German controls via two polymorphisms in the gamma-synuclein gene. No significant differences in the allelic or genotypic distributions of the investigated polymorphisms were observed between patients and controls. In addition no evidence for an increased risk of combined genotypes of polymorphisms in the gamma-synuclein and the alpha-synuclein gene was found. Therefore, our results do not support a major role of the gamma-synuclein gene in PD.
authors.affiliation: Department of Neurology, Ruhr-University, St. Josef-Hospital, Bochum, Germany. rejko.krueger@unit_tuebingen.de
authors.forename: R
authors.initials: R
authors.lastname: Krüger
authors.forename: L
authors.initials: L
authors.lastname: Schöls
authors.forename: T
authors.initials: T
authors.lastname: Müller
authors.forename: W
authors.initials: W
authors.lastname: Kuhn
authors.forename: D
authors.initials: D
authors.lastname: Woitalla
authors.forename: H
authors.initials: H
authors.lastname: Przuntek
authors.forename: J T
authors.initials: JT
authors.lastname: Epplen
authors.forename: O
authors.initials: O
authors.lastname: Riess
mesh_terms: D000368:Aged; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D051843:Synucleins; D051844:alpha-Synuclein; D051845:gamma-Synuclein
chemical_list: D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein; D051845:gamma-Synuclein