[Biochemical mechanism of ulcer development under stressful conditions].
Using the model of acute immobilizing stress in rats it has been established that the content of N-acetylneuraminic acid, hexoses connected with protein, acid glycosaminoglycanes and fucouse in a structure of gastric mucus increases alongside with growth of proteolytic enzymes activity in it. The received results justify an important role of noncollagenic proteins and proteolytic enzymes in provision of resistancy of stomach mucous membrane and mechanisms of stressory ulcers development.
Skrypnyk
I M
IM
Ukrainian Medical Stomatological Academy, Ministry of Public Health of Ukraine, Poltava. stanua@excite.com
D000818:Animals; D010450:Endopeptidases / Q000378:metabolism; D005643:Fucose / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism; D007103:Immobilization; D008297:Male; D009093:Mucus / Q000378:metabolism; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000209:etiology / Q000378:metabolism*; D013312:Stress, Physiological / Q000150:complications*
D006025:Glycosaminoglycans; D006601:Hexoses; D005643:Fucose; D010450:Endopeptidases; D019158:N-Acetylneuraminic Acid