Preliminary results on the effects of CD40/CD40L interactions and SAC-induction on IFN-gamma expression in human schistosomiasis.
In this communication the authors analyzed the pattern of expression of IFN-gamma as a surrogate type 1 response in different clinical forms of schistosomiasis in response to stimulation involving T-cell dependent and T-cell independent pathways, to investigate which pathways were functional in human schistosomiasis, and to further characterize the nature of Th1 response impairment in this parasitic disease.
Montenegro
S M
SM
Centro de Pesquisas Aggeu Magalhães, Fiocruz, Recife, PE, 50670-420, Brasil. silvia@cpqam.fiocruz.br
Abath
F G
FG
Domingues
A L
AL
Melo
W
W
de Morais
C N
CN
Coutinho
E M
EM
Mahanty
S
S
Wynn
T
T
D019013:CD40 Antigens / Q000378:metabolism / Q000502:physiology*; D023201:CD40 Ligand / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000378:metabolism*; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism
D019013:CD40 Antigens; D023201:CD40 Ligand; D007371:Interferon-gamma