Microarrays for studying the host transcriptional response to microbial infection and for the identification of host drug targets.
It is essential to understand the molecular basis of a host's response to microbial infection so that disease and tissue damage can be prevented. Modulation of host RNA expression is a critical set of molecular changes that occur upon infection. Global analysis of gene expression should provide an understanding of host RNA transcriptional changes that occur upon host-pathogen interaction. This series of articles focuses on the use of microarrays for analyzing the transcriptional response of a host to microbial infection and for drug target identification.
Yowe
D
D
Millennium Pharmaceuticals, Cambridge, MA 02139, USA. yowe@mpi.com
Cook
W J
WJ
Gutierrez-Ramos
J C
JC
D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D016503:Drug Delivery Systems; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000235:genetics; D014158:Transcription, Genetic; D014777:Virus Diseases / Q000188:drug therapy / Q000821:virology*
D012313:RNA