11-Demethylcyclosporins exhibit a single conformation in methanol and dimethylsulfoxide.
NMR studies showed that 11-demethylcyclosporin A (cyclosporin E) and 11-demethylcyclosporin B exist as single species both in polar and nonpolar solvents. They adopt the same conformation that was found in the solid state.
Sedmera
P
P
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. sedmera@biomed.cas.cz
Jegorov
A
A
Buchta
M
M
Cvak
L
L
D003524:Cyclosporins / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry*; D008968:Molecular Conformation; D012997:Solvents / Q000737:chemistry
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D012997:Solvents; D000432:Methanol; D004121:Dimethyl Sulfoxide