title: Lymphocytic thyroiditis.
abstract: Lymphocytic thyroiditis is a common canine condition that can lead to functional hypothyroidism. It is associated with more than 50% of cases of canine hypothyroidism. Evidence in human beings and experimental situations suggests that it is a disease of defective immunoregulation, but specific investigation of the molecular pathogenesis of the naturally occurring disease in dogs has not yet been carried out. The condition is heritable in those breeds that have been studied, and progression to hypothyroidism, if it occurs, can be slow. Factors that influence the progression from subclinical thyroiditis to hypothyroidism in dogs are still to be identified, but excessive iodine intake is an important factor in other species.
authors.affiliation: Diagnostic Endocrinology Section, Animal Health Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Graham
authors.forename: R F
authors.initials: RF
authors.lastname: Nachreiner
authors.forename: K R
authors.initials: KR
authors.lastname: Refsal
authors.forename: A L
authors.initials: AL
authors.lastname: Provencher-Bolliger
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D018450:Disease Progression; D004283:Dog Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D007037:Hypothyroidism / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000209:etiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D001323:Autoantibodies; D007455:Iodine