title: Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter.
abstract: It is now well documented that chronic UVA exposure induces damage to human skin. Therefore, modern sunscreens should not only provide protection from both UVB and UVA radiation but also maintain this protection during the entire period of exposure to the sun. UVA filters, however, are rare and not sufficiently photostable. We investigated the effect of the introduction of a new UV filter, bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), in oil in water sunscreen formulations on the photostability of butyl methoxydibenzoylmethane (Avobenzone [AVB]) after irradiation with an optically filtered Xenon arc source (UV irradiance adjusted at 1 mean effective dose [MED]/min). With spectrophotometrical methods to assess the sun protection factor (SPF) and UVA ratio and chromatographical methods to determine the amount of UV filters recovered after irradiation we showed that Tinosorb S prevented the photodegradation of AVB in a concentration-dependent way, leading to a sustained SPF and UVA ratio even after irradiation with doses of up to 30 MED. Since AVB was shown to destabilize ethylhexyl methoxycinnamate (EHM) we tested the effect of Tinosorb S in sunscreens containing this UV filter combination. Here too Tinosorb S showed photoprotective properties toward both UV filters. Thus, Tinosorb S can be used successfully to improve the photostability and efficiency of sunscreens containing AVB and EHM.
authors.affiliation: Department of Biopharmacy, Spirig Pharma Ltd, CH-4622 Egerkingen, Switzerland. eric.chatelain@spirig.ch
authors.forename: E
authors.initials: E
authors.lastname: Chatelain
authors.forename: B
authors.initials: B
authors.lastname: Gabard
mesh_terms: D001565:Benzoates / Q000737:chemistry / Q000528:radiation effects*; D047188:Chalcones; D002626:Chemistry, Pharmaceutical; D002934:Cinnamates / Q000737:chemistry / Q000528:radiation effects*; D004355:Drug Stability; D006801:Humans; D066298:In Vitro Techniques; D010636:Phenols / Q000494:pharmacology*; D010777:Photochemistry; D011427:Propiophenones; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D014227:Triazines / Q000494:pharmacology*; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D001565:Benzoates; D047188:Chalcones; D002934:Cinnamates; D010636:Phenols; D011427:Propiophenones; D013473:Sunscreening Agents; D014227:Triazines; C118580:octylmethoxycinnamate; C049935:avobenzone; C439083:bis-ethylhexyloxyphenol methoxyphenyl triazine