Neuroactive steroids and central nervous system disorders.
Steroid hormones are vital for the cell life and affect a number of neuroendocrine and behavioral functions. In contrast to their endocrine actions, certain steroids have been shown to rapidly alter brain excitability and to produce behavioral effects within seconds to minutes. In this article we direct attention to this issue of neuroactive steroids by outlining several aspects of current interest in the field of steroid research. Recent advances in the neurobiology of neuroactive are described along with the impact of advances on drug design for central nervous system (CNS) disorders provoked by neuroactive steriods. The theme was selected in association with the clinical aspects and therapeutical potentials of the neuroactive steroids in CNS disorders. A wide range of topics relating to the neuroactive steroids are outlined, including steroid concentrations in the brain, premenstrual syndrome, estrogen and Alzheimer's disease, side effects of oral contraceptives, mental disorder in menopause, hormone replacement therapy, Catamenial epilepsy, and neuractive steroids in epilepsy treatment.
Wang
M
M
Department of Obstetrics and Gynecology, Department of Medicine, Department of Pharmacology, University of Umeå, S-901 87 Umeå, Sweden.
Bäckström
T
T
Sundström
I
I
Wahlström
G
G
Olsson
T
T
Zhu
D
D
Johansson
I M
IM
Björn
I
I
Bixo
M
M
D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008593:Menopause / Q000502:physiology; D011293:Premenstrual Syndrome / Q000503:physiopathology; D013256:Steroids / Q000502:physiology*
D013256:Steroids