Functional assessment of pancreatic parenchyma after secretin administration using serial T2-weighted echo-planar magnetic resonance imaging.
Signal intensity (SI) changes of pancreatic parenchyma were evaluated after intravenous administration of secretin using T2-weighted single-shot spin-echo echo-planar imaging (EPI) to assess this method as a magnetic resonance (MR) test of pancreatic exocrine function. Nine volunteers were studied with serial single-shot EPI of the pancreas for 15 minutes after the injection of secretin or saline. The normal pattern of pancreatic SI change was demonstrated after intravenous injection of secretin, a single peak at 3-4 minutes in the head, body, and tail, followed by a gradual decrease in SI. Saline injection did not induce a significant SI change. There was no statistical difference in the peak contrast ratios (first mean, 1.21-1.25, vs. second mean, 1.18-1.22) and peak times (first mean, 3.2-3.7 minutes, vs. second mean, 3.1-3.6) in a repeat study. By evaluating the pattern of time-response curves obtained from serial T2-weighted EPI after secretin injection, pancreatic exocrine function may be directly assessed at the level of the head, body, and tail.
Masui
T
T
Department of Radiology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Hamamatsu, 430-8558, Japan. masui@sis.seirei.or.jp
Katayama
M
M
Kobayashi
S
S
Ito
T
T
Kabasawa
H
H
Nozaki
A
A
Sakahara
H
H
D000328:Adult; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010179:Pancreas / Q000033:anatomy & histology*; D010186:Pancreatic Function Tests / Q000379:methods*; D015203:Reproducibility of Results; D012633:Secretin / Q000008:administration & dosage
D012633:Secretin