Lactate dehydrogenase isozymes in and intralesional steroid injection therapy for pseudocyst of the auricle.
BACKGROUND
Various treatments for pseudocyst of the auricle have been reported. Recently, several patients have been treated successfully with steroid injections. The lactate dehydrogenase (LDH) levels of cystic fluid have been reported to be high, and the LDH-4 and LDH-5 isozymes were found to predominate, although the serum LDH levels and LDH isozyme patterns were normal.


OBJECTIVE
To find a way of preventing auricular pseudocyst recurrences after steroid injection therapy and to examine the relationships between recurrences and the LDH level and isozyme pattern of the cystic fluid.


METHODS
Steroid injection therapy was given to nine Japanese patients with pseudocyst of the auricle at our clinic between 1994 and 1999. We determined the LDH level and isozyme pattern of the cystic fluid and sera of seven patients.


RESULTS
All nine patients in this series were treated successfully with steroid injections, although three suffered recurrences. Although the serum LDH levels of seven patients were almost normal, their cystic fluid LDH levels were very high. LDH-4 and LDH-5 predominated in the cystic fluid of all seven, although their serum LDH isozyme patterns were virtually normal.


CONCLUSIONS
Auricular pseudocyst recurrences show no relationship with either the LDH levels or isozyme pattern. An undiluted solution of steroid fluid should be used in order to prevent recurrences.
Miyamoto
H
H
Division of Dermatology, Kanagawa Cancer Center, Nakao, Asahi-ku, Yokohama, Japan. brb60130@nifty.com
Okajima
M
M
Takahashi
I
I
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003560:Cysts / Q000175:diagnosis / Q000188:drug therapy* / Q000201:enzymology*; D004427:Ear Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000201:enzymology*; D004431:Ear, External; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D007770:L-Lactate Dehydrogenase / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013256:Steroids / Q000008:administration & dosage*; D016896:Treatment Outcome
D015415:Biomarkers; D013256:Steroids; D007770:L-Lactate Dehydrogenase