title: [A case of relapsing polychondritis monitored by daily peak flow measurement].
abstract: A 55-year-old man was admitted to our hospital with dyspnea and stridor. At presentation, he also had a low grade fever, arthralgia and nasal obstruction. His chest roentgenogram showed diffuse tracheal narrowing, and chest CT revealed a thickened tracheal wall and fractured cricoid and thyroid cartilages. A diagnosis of relapsing polychondritis was made on the basis of his symptoms and in accordance with Damiani's criteria and CT findings. Daily peak flow (PEF) monitoring was carried out to assess the disease condition of the trachea. Methylprednisolone pulse therapy was started, and was followed by oral prednisolone, which improved his condition immediately, but reduction of oral prednisolone led to recurrence. The clinical course was clearly evaluated by PEF monitoring, but the change was undetectable on chest CT. Dapson, cyclophosphamide, and inhaled steroid were administered with oral prednisolone and the patient's condition has since been fair and stable. PEF monitoring may be useful for the early detection of recurrence in cases of relapsing polychondritis.
authors.affiliation: Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Ishikawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Abo
authors.forename: K
authors.initials: K
authors.lastname: Nishi
authors.forename: T
authors.initials: T
authors.lastname: Kita
authors.forename: A
authors.initials: A
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Ooka
authors.forename: M
authors.initials: M
authors.lastname: Fujimura
authors.forename: S
authors.initials: S
authors.lastname: Nakao
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010366:Peak Expiratory Flow Rate; D011081:Polychondritis, Relapsing / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D014132:Trachea / Q000503:physiopathology