title: Heart rate variability and its determinants in patients with severe or mild essential hypertension.
abstract: How cardiac autonomic nervous control is related to the severity of essential hypertension in patients receiving long-term antihypertensive therapy is not well known. The aim of this study was to examine heart rate variability (HRV), a non-invasive measure of cardiac autonomic function, in patients with long-term and medically treated mild and severe essential hypertension and healthy control subjects, and to assess the clinical determinants of HRV in these patients. Thirty-four patients with severe essential hypertension (SEHT) and 29 with mild essential hypertension (MEHT) as well as healthy age- and sex-matched control subjects were studied. HRV was assessed from 10 min ECG-recordings during paced (0.2 Hz) breathing at rest and expressed as time and frequency domain measures. In the SEHT group time (SDNN, RMSSD) and frequency domain measures (total power, low-frequency (LF) power and high-frequency (HF) power of HRV in absolute units, and LF and HF power of HRV in normalized units) of HRV were significantly lower when compared with those of the control group. The MEHT and control groups did not differ from each other with respect to time or frequency domain measures of HRV. Comparison between the hypertensive groups showed that SDNN, total power, LF power and HF power were lower in the SEHT group compared with the MEHT group (P<0.05 for all). Among hypertensive patients RR-interval, age, gender, systolic finger blood pressure and diastolic office blood pressure as well as 24-h blood pressure were significant determinants of HRV. In conclusion, we found that the severity of chronic essential hypertension seems to be related to the severity of impairment of cardiac autonomic control.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Kuopio, FIN-70211 Kuopio, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Mussalo
authors.forename: E
authors.initials: E
authors.lastname: Vanninen
authors.forename: R
authors.initials: R
authors.lastname: Ikäheimo
authors.forename: T
authors.initials: T
authors.lastname: Laitinen
authors.forename: M
authors.initials: M
authors.lastname: Laakso
authors.forename: E
authors.initials: E
authors.lastname: Länsimies
authors.forename: J
authors.initials: J
authors.lastname: Hartikainen
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012720:Severity of Illness Index