Prognostic factors related to cervical cancer survival in Mexican women.
OBJECTIVE
To identify prognostic survival factors among Mexican women with cervical cancer.


METHODS
A total of 378 women with cervical cancer admitted from 1984 to 1996 to our referral hospital were evaluated, using survival analysis (Kaplan-Meier and Cox proportional hazards method). We designed a symptom index which included asymptomatic conditions, severity of symptoms and comorbidity.


RESULTS
Overall 5-year survival was 66.6%. The shortest survival time was for FIGO stage IV (21.5%, P<0.001) and adenosquamous histologic type (53.1%, P=0.15). The main prognostic factors were primary symptoms (RR, 2.6; 95% CI, 1.02-6.66); systemic symptoms (RR, 3.3; 95% CI, 1.23-9.01); FIGO stage IV (RR, 5.5; 95% CI, 2.36-12.96); and oncogenic symptoms (prognostic comorbidity present) (RR, 2.3; 95% CI, 1.08-4.89).


CONCLUSIONS
Our findings show that clinical stage and several types of symptoms influence CC survival. This present strategy to assess morphological and clinical characteristics may be a more accurate indicator of survival rate and potentially an efficient indicator of new therapeutic alternatives.
Flores-Luna
L
L
Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Morelos, Mexico. mflor@correo.insp.mx
Salazar-Martinez
E
E
Escudero-De los Rios
P
P
Gonzalez-Lira
G
G
Zamora-Muñoz
S
S
Lazcano-Ponce
E
E
D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology; D018196:Carcinoma, Adenosquamous / Q000401:mortality* / Q000473:pathology; D003075:Coitus; D005260:Female; D006801:Humans; D008572:Menarche; D008800:Mexico; D008875:Middle Aged; D009367:Neoplasm Staging; D018307:Neoplasms, Squamous Cell / Q000401:mortality* / Q000473:pathology; D010298:Parity; D011379:Prognosis; D016016:Proportional Hazards Models; D012306:Risk; D012720:Severity of Illness Index; D016019:Survival Analysis; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000473:pathology