Glatiramer acetate in the treatment of multiple sclerosis.
This review article summarises the initial preclinical studies as well as the different stages of clinical trials in multiple sclerosis (MS) with Copolymer 1 (Cop 1), recently denoted glatiramer acetate. Experimental studies on autoimmune encephalomyelitis (EAE), the animal model of MS, as well as studies on the mechanism of action in both animals and humans are discussed. The review describes the early clinical trials which were followed by Phase II and III trials, culminating in FDA approval in 1996 for the treatment of relapsing-remitting MS. The accumulated experience with glatiramer acetate indicates that its efficacy is apparently increased as a function of usage time while the favourable side effect profile is sustained. MRI studies revealed that treatment with glatiramer acetate resulted in a significant reduction of gadolinium (Gd)-enhancing lesions. Ongoing clinical trials which might extend its usage or change its mode of delivery are also described. Glatiramer acetate appears to be a treatment of choice for the relapsing-remitting type of MS.
Sela
M
M
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. michael.sela@weizmann.ac.il
Teitelbaum
D
D
D000818:Animals; D000917:Antibody Formation; D002986:Clinical Trials as Topic; D003429:Cross Reactions; D017277:Drug Approval; D004660:Encephalitis / Q000276:immunology / Q000628:therapy; D000068717:Glatiramer Acetate; D017408:Guidelines as Topic; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D015337:Multicenter Studies as Topic; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D004676:Myelin Basic Protein / Q000276:immunology; D010352:Patient Dropouts; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D007166:Immunosuppressive Agents; D004676:Myelin Basic Protein; D010455:Peptides; D000068717:Glatiramer Acetate