[The effects of beta-aminopropionitrile on the proliferation in cultrured human hypertrophic scar fibroblasts].
OBJECTIVE
To observe the effects of BAPN on the proliferation in cultured human hypertrophic scar fibroblasts.


METHODS
By means of colorimetric MTT(tetrazolium) assay and flow cytometry, we tried to find the effects of BAPN with different concentrations and different time on the proliferation in cultured human hypertrophic scar fibroblasts.


RESULTS
Concentrations of BAPN 0.074, 0.222, 0.667, 2.0, 6.0 mg/ml could inhibit proliferation in cultured human hypertrophic scar fibroblasts, but had no effects on cultured human normal dermal fibroblasts. Its ID50 is 2.53 mg/ml.


CONCLUSIONS
BAPN could inhibit proliferation in cultured human hypertrophic scar fibroblasts and was dependent on concentration and time.
Jin
Y
Y
Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, PR China.
Luo
S
S
Hao
X
X
D000293:Adolescent; D000328:Adult; D000629:Aminopropionitrile / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D017439:Cicatrix, Hypertrophic / Q000473:pathology*; D003094:Collagen / Q000096:biosynthesis; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans
D000629:Aminopropionitrile; D003094:Collagen