Nodular regenerative hyperplasia of the liver in a patient with celiac disease.
We present the case of dual adult celiac disease and liver disease with portal hypertension (esophageal varices); a percutaneous liver biopsy was compatible with nonspecific reactive hepatitis. Clinically, celiac disease was characterised by poor response to a gluten-free diet, with the development of a biochemical cholestasis and marked malnutrition. Our patient died of cerebral hemorrhage, at the age of 50 years, without associated risk factors. The necropsy demonstrated the existence of a nodular regenerative hyperplasia of the liver, splenic atrophy, gelatinous transformation of the bone marrow, and lymphocytic colitis. We discuss the different types of liver disorders associated with celiac disease and the possible relation between nodular regenerative hyperplasia and celiac disease, based on immunologic mechanisms.
Riestra
S
S
Digestive Unit, Hospital Valle del Nalón, Asturias, Spain. sriestram@medynet.com
Domínguez
F
F
Rodrigo
L
L
D001344:Autopsy; D001707:Biopsy, Needle; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis; D002543:Cerebral Hemorrhage / Q000175:diagnosis; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D006975:Hypertension, Portal / Q000150:complications* / Q000175:diagnosis; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged