[EROD induction in liver microsome of carp(Cyprinus carpio) by nitroaromatic hydrocarbons in vitro].
Nine nitroaromatic hydrocarbons (NAHs) induction of EROD activity was investigated by an in vitro assay based on carp (Cyprinus carpio) hepatic microsome system. All nine NAHs tested were found to induce the activity of EROD. There was dose-effect relationship between EROD activity and concentrations of NAHs. It was found that EROD activity was different, when different groups substituted at the same position of benzene ring, or the same group was at different position of benzene ring.
Wang
Y
Y
SKLEAC, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085.
Wang
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C
Wang
Z
Z
Xu
J
J
D000818:Animals; D002347:Carps; D019363:Cytochrome P-450 CYP1A1 / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D006841:Hydrocarbons, Aromatic / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000201:enzymology*; D013329:Structure-Activity Relationship
D004785:Environmental Pollutants; D006841:Hydrocarbons, Aromatic; D019363:Cytochrome P-450 CYP1A1