Bradykinin B2BKR receptor polymorphism and left-ventricular growth response.
Angiotensin-converting-enzyme (ACE) activity regulates left-ventricular growth. The deletion (D), rather than the insertion (I), ACE gene variant is associated with increased ACE activity and kinin degradation, and the absence (-) rather than the presence (+) of a 9 bp deletion in the gene encoding the bradykinin 2 receptor (B2BKR) is associated with greater gene expression. We determined the ACE and B2BKR genotype of 109 male army recruits, and measured their physiological left-ventricular growth response to a 10-week physical training programme. Mean left-ventricular growth was 15.7 g (SE 3.5) in those with ACE genotype D/D and B2BKR genotype +9/+9, but -1.37 g (4.1) in those with ACE genotype I/I and B2BKR genotype -9/-9 (p=0.003 for trend across genotypes). These results suggest that kinins regulate left-ventricular growth, mediating some of the effects of ACE in this regard.
Brull
D
D
Dhamrait
S
S
Myerson
S
S
Erdmann
J
J
Woods
D
D
World
M
M
Pennell
D
D
Humphries
S
S
Regitz-Zagrosek
V
V
Montgomery
H
H
D000328:Adult; D015444:Exercise; D005838:Genotype; D006352:Heart Ventricles / Q000254:growth & development*; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin / Q000235:genetics*
D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin; D007703:Peptidyl-Dipeptidase A