[Temperature-dependent contractions of the guinea pig vas deferens mediated by P2X receptors].
The P2X receptor agonist alpha,beta-methylene ATP and purinergic electrical stimulation induce contractility response in guinea pig vas deferens. The low-temperature response observed at 30 degrees C was markedly greater than that at 37 degrees C and 42 degrees C. The P2X receptor antagonist pyridoxal-6-phosphate-2',4'-disulfonic acid stronger inhibits the electric-field-induced contractility at 30 degrees C than at 37 or 42 degrees C, while no such difference was observed for the inhibition of contractility induced by alpha,beta-methylene ATP.
Ziganshin
A U
AU
Pharmacology Department, State Medical University, ul. Butlerova 49, Kazan, Tatarstan, 420012 Russia.
Ziganshina
L E
LE
Rychkov
A V
AV
Zaĭtsev
A P
AP
Falu
Zh Iu
ZhIu
Khaziakhmetov
D F
DF
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D018048:Receptors, Purinergic P2 / Q000187:drug effects / Q000502:physiology*; D058476:Receptors, Purinergic P2X2; D013696:Temperature; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology*
D018048:Receptors, Purinergic P2; D058476:Receptors, Purinergic P2X2; C077792:pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid; D011732:Pyridoxal Phosphate; D000255:Adenosine Triphosphate; C002630:alpha,beta-methyleneadenosine 5'-triphosphate