title: Lung lesions and anti-ulcer agents beneficial effect: anti-ulcer agents pentadecapeptide BPC 157, ranitidine, omeprazole and atropine ameliorate lung lesion in rats.
abstract: Anti-ulcer agents may likely attenuate lesions outside the gastrointestinal tract, since they had protected gastrectomized rats (a "direct cytoprotective effect"). Therefore, their therapeutic potential in lung/stomach lesions were shown. Rats received an intratracheal (i.t.) HCl instillation [1.5 ml/kg HCl (pH 1.75)] (lung lesion), and an intragastric (i.g.) instillation of 96% ethanol (gastric lesion; 1 ml/rat, 24 h after i.t. HCl instillation), then sacrificed 1 h after ethanol. Basically, in lung-injured rats, the subsequent ethanol-gastric lesion was markedly aggravated. This aggravation, however, in turn, did not affect the severity of the lung lesions in the further period, at least for 1 h of observation. Taking intratracheal HCl-instillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (10 microg, 10 ng, 10 pg), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg), were given [/kg, intraperitoneally (i.p.)] (i) once, only prophylactically [as a pre-treatment (at -1h)], or as a co-treatment [at 0)], or only therapeutically (at +18h or +24 h); (ii) repeatedly, combining prophylactic/therapeutic regimens [(-1 h)+(+24 h)] or [(0)+(+24 h)], or therapeutic/therapeutic regimens [(+18 h)+(+24 h)]. For all agents, combining their prophylactic and salutary regimens (at -1 h/+24 h, or at 0/+24 h) attenuated lung lesions; even if effect had been not seen already with a single application, it became prominent after repeated treatment. In single application studies, relative to controls, a co-treatment (except to omeprazole), a pre-treatment (at -1 h) (pentadecapeptide BPC 157 and atropine, but not ranitidine and omeprazole) regularly attenuated, while therapeutically, atropine (at +18 h), pentadecapeptide BPC 157 highest dose and omeprazole (at +24 h), reversed the otherwise more severe lung lesions.
authors.affiliation: Clinic for Thoracic Surgery Jordanovac, Medical Faculty University of Zagreb, Zagreb, Croatia.
authors.forename: D
authors.initials: D
authors.lastname: Stancic-Rokotov
authors.forename: Z
authors.initials: Z
authors.lastname: Slobodnjak
authors.forename: J
authors.initials: J
authors.lastname: Aralica
authors.forename: G
authors.initials: G
authors.lastname: Aralica
authors.forename: D
authors.initials: D
authors.lastname: Perovic
authors.forename: M
authors.initials: M
authors.lastname: Staresinic
authors.forename: M
authors.initials: M
authors.lastname: Gjurasin
authors.forename: T
authors.initials: T
authors.lastname: Anic
authors.forename: I
authors.initials: I
authors.lastname: Zoricic
authors.forename: G
authors.initials: G
authors.lastname: Buljat
authors.forename: I
authors.initials: I
authors.lastname: Prkacin
authors.forename: P
authors.initials: P
authors.lastname: Sikiric
authors.forename: S
authors.initials: S
authors.lastname: Seiwerth
authors.forename: R
authors.initials: R
authors.lastname: Rucman
authors.forename: M
authors.initials: M
authors.lastname: Petek
authors.forename: B
authors.initials: B
authors.lastname: Turkovic
authors.forename: N
authors.initials: N
authors.lastname: Kokic
authors.forename: V
authors.initials: V
authors.lastname: Jagic
authors.forename: A
authors.initials: A
authors.lastname: Boban-Blagaic
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use*; D006851:Hydrochloric Acid; D008171:Lung Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control*; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000627:therapeutic use*; D011506:Proteins / Q000627:therapeutic use*; D011899:Ranitidine / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000897:Anti-Ulcer Agents; D010446:Peptide Fragments; D011506:Proteins; D001285:Atropine; D011899:Ranitidine; C083833:BPC 157; D009853:Omeprazole; D006851:Hydrochloric Acid