A new double coupling system: synthesis of citronellyl acetate via transacetylation to citronellol from acetyl coenzyme A produced from glucose and free fatty acids.
A double coupling system, which couples metabolism of glucose and transacetylation, is a unique procedure for the production of acetic esters. In the novel coupling system described in this article, acetyl coenzyme A (acetyl-CoA) was supplied via metabolism of both glucose and exogenous saturated fatty acids. While short and middle chain fatty acids having C4-8 were very biotoxic, myristic acid (C14) was effectively used as a source of acetyl-CoA.
Oda
S
S
Technical Research Laboratory, Kansai Paint Co., Ltd., Hiratsuka, Kanagawa, Japan. odas@als.kansai.co.jp
Ohta
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H
D000105:Acetyl Coenzyme A / Q000737:chemistry*; D000107:Acetylation; D000080462:Acyclic Monoterpenes; D005230:Fatty Acids, Nonesterified / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D039821:Monoterpenes; D019814:Myristic Acid / Q000737:chemistry; D010843:Pichia / Q000201:enzymology; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry*
D000080462:Acyclic Monoterpenes; D005230:Fatty Acids, Nonesterified; D039821:Monoterpenes; D013729:Terpenes; D019814:Myristic Acid; D000105:Acetyl Coenzyme A; D005947:Glucose; C040879:citronellyl acetate; C007078:citronellol