title: Current management of acute ischemic stroke. Part 1: Thrombolytics and the 3-hour window.
abstract: OBJECTIVE
  To help family physicians who care for patients with acute stroke or who are involved in planning service delivery or resource allocation to understand recent developments in acute stroke care.
  
  
  METHODS
  A MEDLINE search indicated that most data were derived from well designed, randomized, double-blind, placebo-controlled trials, including all the largest international studies and large systematic reviews.
  
  
  RESULTS
  Treatment of acute stroke with tissue plasminogen activator seems beneficial for certain patients with certain kinds of stroke. Because thrombolytic therapy is not without risk and requires substantial resources, it should be administered only by physicians trained in its use and in centres with the necessary experience and resources. Because time is important, an organized and efficient system of stroke care with collaboration between hospital and prehospital care providers and help from ordinary citizens is essential.
  
  
  CONCLUSIONS
  Management of acute stroke is an emerging discipline; many potential therapies are still experimental.
authors.affiliation: Department of Emergency Medicine, Department of Family Medicine at the University of Manitoba in Winnipeg. aherd@hsc.mb.ca
authors.forename: A M
authors.initials: AM
authors.lastname: Herd
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000188:drug therapy*; D003695:Delivery of Health Care; D004334:Drug Administration Schedule; D005194:Family Practice; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D005343:Fibrinolytic Agents