Modulation of the severity of experimental autoimmune encephalomyelitis by gammadelta T lymphocytes activated by mycobacterial antigens.
Immunity to mycobacterial antigens may contribute to the maintenance of self-tolerance. Exposure of the immune system to mycobacterial antigen might well stimulate the immune system to exert control over unwanted self-reactive clones. We demonstrated that in vivo administration of Mycobacterium tuberculosis, PPD, and PPD peptide (180-196) prior to immunization with Myelin Basic Protein (MBP) led to a moderate increase of gammadelta T cells, suppression of the immune response, and reduction in the severity of Experimental Autoimmune Encephalomyelitis. The immunosuppression observed is due, at least in part, to the production of Transforming growth factor-beta (TGFbeta) by the gammadelta T lymphocytes.
Diaz-Bardales
B M
BM
Department of Microbiology and Immunology, University of Campinas, Sao Paulo, Brazil.
Novaski
S M
SM
Goes
A E
AE
Castro
G M
GM
Mengel
J
J
Santos
L M
LM
D019264:Adoptive Transfer; D000818:Animals; D016525:Antigenic Modulation; D000942:Antigens, Bacterial / Q000276:immunology* / Q000494:pharmacology; D002455:Cell Division / Q000276:immunology; D002478:Cells, Cultured; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D005260:Female; D008213:Lymphocyte Activation / Q000276:immunology; D009161:Mycobacterium / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000187:drug effects / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis; D014373:Tuberculin / Q000494:pharmacology
D000942:Antigens, Bacterial; D004676:Myelin Basic Protein; D016692:Receptors, Antigen, T-Cell, gamma-delta; D016212:Transforming Growth Factor beta; D014373:Tuberculin