title: Inhibitory effects of capsaicinoids on fatty acid desaturation in a rat liver cell line.
abstract: The inhibitory effects of such vanillylamides as capsaicin and nine capsaicinoids on fatty acid desaturation in liver cells were investigated by using the cultured rat liver cell line, BRL-3A. When capsaicin was added to the medium, it had a relatively strong inhibitory effect on delta6 desaturation and clear inhibitory effects on delta5 and C24delta16 desaturation (delta16 desaturation of C24-polyunsaturated fatty acids). Capsaicinoids with side carbon chain lengths of C10:0 and C12:0 expressed the maximum inhibitory effects of the nine capsaicinoids on fatty acid desaturation in the BRL-3A cells. The inhibitory effects of the capsaicinoids were not correlated with their pungency.
authors.affiliation: Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University, Nara, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Nakano
authors.forename: N
authors.initials: N
authors.lastname: Shirasaka
authors.forename: K
authors.initials: K
authors.lastname: Masuoka
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Kobata
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Yoshizumi
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002212:Capsicum / Q000737:chemistry*; D002460:Cell Line; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D005231:Fatty Acids, Unsaturated; D002211:Capsaicin