title: Impaired detection of variable duration embedded tones in ectopic NZB/BINJ mice.
abstract: Utilizing rodent models, prior research has demonstrated a significant association between focal neocortical malformations (i.e. induced microgyria, molecular layer ectopias), which are histologically similar to those observed in human dyslexic brains, and rate-specific auditory processing deficits as seen in language impaired populations. In the current study, we found that ectopic NZB/BINJ mice exhibit significant impairments in detecting a variable duration 5.6 kHz tone embedded in a 10.5 kHz continuous background, using both acoustic reflex modification and auditory event-related potentials (AERP). The current results add further support to the association between focal cortical malformations and impaired auditory processing, and the notion that these auditory effects may occur regardless of the cortical location of the anomaly.
authors.affiliation: Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, 3107 Horse Barn Hill Rd. Unit 4154, Storrs, CT 06269-4154, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Peiffer
authors.forename: C K
authors.initials: CK
authors.lastname: Dunleavy
authors.forename: M
authors.initials: M
authors.lastname: Frenkel
authors.forename: L A
authors.initials: LA
authors.lastname: Gabel
authors.forename: J J
authors.initials: JJ
authors.lastname: LoTurco
authors.forename: G D
authors.initials: GD
authors.lastname: Rosen
authors.forename: R H
authors.initials: RH
authors.lastname: Fitch
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D001308:Auditory Perceptual Disorders / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004410:Dyslexia / Q000473:pathology / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D009421:Nervous System Malformations / Q000473:pathology / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology