title: [Value of human recombinant osteogenetic proteins as bone replacement materials in lumbar spondylodesis. Results of an animal experiment study].
abstract: Up to now autologous spongiosa may be considered as the golden standard for the filling up of bone defects. Because of the limited quantity, complications at the extraction place and the increasing problems concerning infections when using homologous spongiosa the development of various bone replacement materials was intensified during the last years. The development of various osteogenetic proteins as well as experimental studies using these proteins represent a main point in science at present. It is expected that these substances will lead to a qualitative improvement and increase of bone healing. In the presented study influence of various osteogenetic substances to bone regeneration was examined at 30 breeding sheep after a ventral spine fusion of the segment L4/L5 by a dorsal approach. Bone defect filling was realized at each 10 animals with autologous spongiosa, Bio-Oss as well as the osteogenetic protein 1 (OP-1). To evaluate the progress and outcome of the segmental fusion during a post-operative period of 24 weeks x-ray controls were performed. In the 24th postoperative week after euthanasia of the experimental animals x-ray controls as well as computed and magnetic resonance tomographies were carried out. The results of 26 experimental animals could be analysed. The results were evaluated according to the criterias of an own score-system. Compared with autologous spongiosa OP-1 as a biomaterial for the fusion of spine-sections led to favorable radiologic results because of higher score values concerning the capability of fusion. Our experiences with Bio-Oss demonstrated lower osteogenetic potency after defect filling with this substance. Therefore we cannot recommend Bio-Oss as filling material for the fusion in spine surgery.
authors.affiliation: Universitätsklinikum, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen.
authors.forename: O
authors.initials: O
authors.lastname: Paar
authors.forename: S
authors.initials: S
authors.lastname: Andereya
authors.forename: G
authors.initials: G
authors.lastname: Staatz
authors.forename: T
authors.initials: T
authors.lastname: Ambacher
authors.forename: H J
authors.initials: HJ
authors.lastname: Erli
mesh_terms: D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D012756:Sheep; D013123:Spinal Fusion; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016212:Transforming Growth Factor beta
chemical_list: C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D016212:Transforming Growth Factor beta