Age-Related decrease in calcitonin gene-related peptide mRNA in the dorsal root ganglia of spontaneously hypertensive rats.
Age-related changes in levels of calcitonin gene-related peptide (CGRP) mRNA of the dorsal root ganglia was studied in 8-, 12- and 15-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKY). CGRP mRNA levels in SHR but not in WKY decreased with age. The contents of CGRP-like immunoreactivities in the atrium and mesenteric artery of 15-week-old SHR were greater than those in age-matched WKY. These results suggest that the outflow of CGRP-containing nerves from the spinal cord and CGRP release from CGRP nerve terminals decreases in SHR.
Yamaga
N
N
Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Okayama University, Japan.
Kawasaki
H
H
Inaizumi
K
K
Shimizu
M
M
Nakamura
A
A
Kurosaki
Y
Y
D000375:Aging / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D015152:Blotting, Northern; D015740:Calcitonin Gene-Related Peptide / Q000235:genetics / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005727:Ganglia, Spinal / Q000378:metabolism*; D005786:Gene Expression Regulation; D006325:Heart Atria / Q000378:metabolism; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D016555:Matched-Pair Analysis; D008638:Mesenteric Arteries / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D012333:RNA, Messenger; D015740:Calcitonin Gene-Related Peptide