title: Antiviral action of Euphorbium compositum and its components.
abstract: BACKGROUND
  Euphorbium compositum SN (Biologische Heilmittel Heel GmbH, Baden-Baden, Germany, a homeopathic combination preparation available in form of drops, nasal spray, and injection solution), is prescribed for inflammation of the mucosae of the nose and sinuses. Infections in these areas are primarily of viral origin although bacterial superinfections are also common.
  
  
  OBJECTIVE
  The main question was whether or not this homeopathic remedy shows an activity against viruses responsible for infections of the respiratory tract.
  
  
  METHODS
  This in vitro study using virus plaque reduction assays examined the effect of Euphorbium compositum SN against pathogens causing various viral infections: influenza A virus, respiratory syncytial virus (RSV), human rhinovirus (HRV) and herpes simplex virus type 1 (HSV-1).
  
  
  RESULTS
  Analysis of virus production after treatment of the infected cells with the remedy showed an antiviral activity of Euphorbium compositum SN against RSV and HSV-1. In addition, an antiviral effect against influenza A virus and HRV, though minimal, was, also noted. Analyses of the plant-derived components of Euphorbium compositum SN, e.g. Euphorbium resinifera, Pulsatilla pratensis and Luffa operculata for their antiviral activity revealed a clear activity of Euphorbium resinifera and Pulsatilla pratensis against RSV. In contrast, no effect was detected using the same protocol with Luffa operculata.
  
  
  CONCLUSIONS
  Euphorbium resinifera and Pulsatilla pratensis as components of Euphorbium compositum SN are responsible for its antiviral activity.
authors.affiliation: Labor Dr. Glatthaar, Reutlingen. LaborDr.Glatthaar@t-online.de
authors.forename: B
authors.initials: B
authors.lastname: Glatthaar-Saalmüller
authors.forename: P
authors.initials: P
authors.lastname: Fallier-Becker
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification; D028481:Euphorbia / Q000737:chemistry*; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000254:growth & development; D006705:Homeopathy; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects / Q000254:growth & development; D012229:Rhinovirus / Q000187:drug effects / Q000254:growth & development; D010948:Viral Plaque Assay; D014777:Virus Diseases / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts