title: Light exposure and the risk of age-related macular degeneration: the Pathologies Oculaires Liées à l'Age (POLA) study.
abstract: BACKGROUND
  The role of light exposure in the development of age-related macular degeneration (ARMD) has been questioned. We present the relationship between lifetime light exposure and ARMD as examined in the Pathologies Oculaires Liées à l'Age (POLA) study.
  
  
  METHODS
  The POLA study is a population-based study on cataract and ARMD and their risk factors. It included 2584 residents of the town of Sète, located in the South of France. The presence of early and late ARMD was assessed on the basis of 50 degrees color fundus photographs using an international classification system. A questionnaire about light exposure was administered.
  
  
  RESULTS
  Late ARMD (n = 38) was not significantly associated with any light exposure variable. Subjects exposed to high ambient solar radiation and those with frequent leisure exposure to sunlight had a decreased risk of pigmentary abnormalities (odds ratio [OR] = 0.61; 95% confidence interval [CI], 0.39-0.93, and OR = 0.70; 95% CI, 0.52-0.95, respectively) and of early signs of ARMD (OR = 0.73; 95% CI, 0.54-0.98, and OR = 0.80; 95% CI, 0.64-1.00, respectively). Subjects who had used sunglasses regularly had a decreased risk of soft drusen (OR = 0.81; 95% CI, 0.66-1.00). These relationships were not modified by further adjustments for potential confounders.
  
  
  CONCLUSIONS
  Our study does not support a deleterious effect of sunlight exposure in ARMD.
authors.affiliation: INSERM Unité 500, 39 Avenue Charles Flahault, 34093 Montpellier, CEDEX 5, France. delcourt@montp.inserm.fr
authors.forename: C
authors.initials: C
authors.lastname: Delcourt
authors.forename: I
authors.initials: I
authors.lastname: Carrière
authors.forename: A
authors.initials: A
authors.lastname: Ponton-Sanchez
authors.forename: S
authors.initials: S
authors.lastname: Fourrey
authors.forename: A
authors.initials: A
authors.lastname: Lacroux
authors.forename: L
authors.initials: L
authors.lastname: Papoz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008268:Macular Degeneration / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D013472:Sunlight