The central noradrenaline system and memory consolidation.
Long-term memory requires de novo protein synthesis and gene expression, which are mediated by certain intracellular signaling pathways. The noradrenaline (NA) system in the CNS is involved in a wide variety of neurological and psychological functions. In addition to previous pharmacological studies, a recent molecular genetic approach provides behavioral evidence for an essential role of the central NA system in long-term memory formation, particularly in memory consolidation. The potential cellular and molecular mechanisms underlying memory formation mediated by NA are discussed.
Kobayashi
K
K
Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Japan. kazuto@fmu.ac.jp
Yasoshima
Y
Y
D000818:Animals; D001921:Brain / Q000502:physiology*; D017774:Long-Term Potentiation; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D015398:Signal Transduction
D009638:Norepinephrine