[Studies on synthesis and pharmacological activities of cimicifugamide from Cimicifuga dahurica, and its analogues].
The total synthesis of cimicifugamide, a new natural compound isolated from the roots of Cimicifuga dahurica, was accomplished by a reaction sequence of seven steps in an overall yield of 31%. Trifluoroacetoxy was used as leaving group at the anomeric carbon. The target product was characterized by IR, MS, 1HNMR, 13CNMR and elemental analysis. In addition, seven analogues were synthesized and their preliminary pharmacological activities were tested.
Ding
P Y
PY
Department of Organic Chemistry, School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083.
Zhu
X X
XX
Cai
M S
MS
Yu
D Q
DQ
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D008113:Liver Neoplasms / Q000473:pathology; D019684:Magnoliopsida / Q000737:chemistry; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; C442157:cimicifugamide