Triterpene constituents from the stem bark of Pinus luchuensis and their DNA topoisomerase II inhibitory effect.
Nine lanostane and serratane-type triterpenes including two unknown compounds were isolated from the stem bark of Pinus luchuensis. These new compounds were characterized as 3-oxolanost-9(11)-ene-24S,25-diol (1) and 29-acetoxy-3beta-methoxyserrat-14-en-21alpha-ol (2) on the basis of spectroscopic evidence. Some of these triterpenes were tested for the inhibitory effect on DNA topoisomerase II activity. Compound 1 showed a slightly less potent inhibitory activity with an IC(50) value of 186 microM.
Wada
S I
SI
Osaka University of Pharmaceutical Sciences, Osaka, Japan.
Iida
A
A
Tanaka
R
R
D000102:Acetyl-CoA C-Acyltransferase / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D028223:Pinus / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C440101:29-acetoxy-3-methoxyserrat-14-en-21-ol; C440102:3-oxolanost-9(11)-ene-24,25-diol; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D059005:Topoisomerase II Inhibitors; D014315:Triterpenes; D005047:Etoposide; D000102:Acetyl-CoA C-Acyltransferase