title: [18F] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism.
abstract: Phosphoinositide metabolism plays an important role in cardiac pathophysiology. To investigate whether [18F]diacylglycerol could be used to trace myocardial phosphoinositide metabolism, lipids were extracted from rat myocardium after the injection. 1-[8-[18F]fluorooctanoyl]-2-palmitoylglycerol and 1-[8-[18F]fluoropalmitoyl]-2-palmitoylglycerol were predominantly metabolized to phosphatidylethanolamine and triacylglycerol, respectively. The radioactivity incorporated into phosphoinositide metabolism was 51, 44, 32, and 30% 3, 5, 10, and 30 minutes after the injection of 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol, respectively. 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol might be a potential tracer to evaluate myocardial phosphoinositide metabolism early after the injection.
authors.affiliation: Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Chida
authors.forename: Y
authors.initials: Y
authors.lastname: Kagaya
authors.forename: S
authors.initials: S
authors.lastname: Nagata
authors.forename: M
authors.initials: M
authors.lastname: Mukoyoshi
authors.forename: S
authors.initials: S
authors.lastname: Namiuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamane
authors.forename: N
authors.initials: N
authors.lastname: Ishide
authors.forename: J
authors.initials: J
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Ido
authors.forename: K
authors.initials: K
authors.lastname: Shirato
mesh_terms: D000818:Animals; D002855:Chromatography, Thin Layer; D005462:Fluorine Radioisotopes; D005990:Glycerol / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D019275:Radiopharmaceuticals / Q000097:blood / Q000138:chemical synthesis; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D005462:Fluorine Radioisotopes; D010716:Phosphatidylinositols; D019275:Radiopharmaceuticals; D005990:Glycerol