title: Use of topical ketanserin for the treatment of ulcers in leprosy patients.
abstract: A comparative study was carried out in which 66 leprosy patients with ulcers were randomly divided in two groups of 33 patients each: Group A (experimental group) was treated with ketanserin gel (2%) and group B with clioquinol cream and/or Lassar paste during a three month period. At the end of the study, when ulcer sizes in the two groups were compared, the group treated with topical ketanserin showed superior results (p < 0.001 using Kolmogorov-Smirnov's test). We conclude that the drug is useful as coadjuavant treatment for healing ulcers in these patients.
authors.affiliation: Dermatologic Institute Guanajuatense, Viveros Revolución S/N Irapuato, Gto, Mexico.
authors.forename: J J
authors.initials: JJ
authors.lastname: Salazar
authors.forename: G G
authors.initials: GG
authors.lastname: Serrano
authors.forename: G I
authors.initials: GI
authors.lastname: Leon-Quintero
authors.forename: B M
authors.initials: BM
authors.lastname: Torres-Mendoza
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007650:Ketanserin / Q000008:administration & dosage / Q000627:therapeutic use*; D007918:Leprosy / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D012702:Serotonin Antagonists; D007650:Ketanserin