Plasma proinflammatory cytokine response to surgical stress in elderly patients.
We investigated the change of plasma cytokines concentrations in elderly patients during lower abdominal surgery. Plasma interleukin (IL-)6 concentrations (68.0+/-15.4 and 36.1+/-20.7 pg/ml) in elderly patients at 24 h and at 3 days after surgery were significantly higher than those (35.1+/-21.5 and 18.6+/-10.6 pg/ml) of young adults. Plasma IL-6 concentrations (92.3+/- 31.9 pg/ml) in elderly patients anesthetized with propofol and fentanyl were significantly higher at the end of the operation than that (57.9+/-36.7 pg/ml) of elderly patients anesthetized with sevoflurane and fentanyl. In conclusion, elderly patients have an increased and delayed IL-6 response to surgical trauma compared with young adults. Plasma IL-6 production after surgical trauma in elderly patients with total intravenous anesthesia with propofol was significantly higher than that in elderly patients with sevoflurane anesthesia.
Kudoh
A
A
Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Aomori, Japan.
Katagai
H
H
Takazawa
T
T
Matsuki
A
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D016207:Cytokines / Q000097:blood*; D005283:Fentanyl / Q000494:pharmacology; D013502:General Surgery; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism; D008738:Methyl Ethers / Q000494:pharmacology; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology; D000077149:Sevoflurane; D013312:Stress, Physiological; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D016207:Cytokines; D015850:Interleukin-6; D008738:Methyl Ethers; D014409:Tumor Necrosis Factor-alpha; D000077149:Sevoflurane; D005283:Fentanyl; D015742:Propofol