title: Management of advanced mandibular osteoradionecrosis with free flap reconstruction.
abstract: BACKGROUND
  The purpose of this study was to assess the effectiveness of free tissue transfer for treatment of advanced mandibular osteoradionecrosis (ORN) in head and neck cancer patients.
  
  
  METHODS
  We reviewed 29 patients who were treated for advanced mandibular ORN by radical resection and reconstruction with free flaps at our institution. All patients had either failed to respond to conservative treatment, including hyperbaric oxygen therapy and debridement or had pathological fracture due to ORN.
  
  
  RESULTS
  Twenty-four vascularized bone (17 fibula, five iliac, and two scapula), four rectus abdominis myocutaneous, and one radial forearm fasciocutaneous free flaps were used. The complications occurred in 6 of 29 patients (21%). A total of four flaps (14%) were lost. The mean follow-up was 2 years 9 months. All patients had complete resolution of ORN symptoms. No evidence of ORN recurrence was observed in any patient.
  
  
  CONCLUSIONS
  For advanced osteoradionecrosis of the mandible, radical resection followed by reconstruction using free flap provides a reliable means of obtaining good wound healing with acceptable aesthetic and functional results.
authors.affiliation: Department of Plastic and Reconstructive Surgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 443, Houston, Texas 77030, USA. dchang@mdanderson.org
authors.forename: D W
authors.initials: DW
authors.lastname: Chang
authors.forename: H K
authors.initials: HK
authors.lastname: Oh
authors.forename: G L
authors.initials: GL
authors.lastname: Robb
authors.forename: M J
authors.initials: MJ
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000601:surgery*; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000601:surgery*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D013524:Surgical Flaps