[An experimental study of metacresol burn].
OBJECTIVE
To study the characteristics of metacresol burn.


METHODS
Metacresol of 99.6% was used. The animals were randomly separated into control group, excision group, topical SD-Ag group, saturated sodium sulfate wet compress group, and warm running water flushing group.


RESULTS
It was proved that metacresol could not only cause deep burns to skin but also penetrate skin and to produce impairment of functions of the main internal organs of the body, as shown by abnormalities in blood BUN, GPT, GOT, GGT, and AKP. Pathological changes were also found in the liver, heart, brain, kidney, and skin with light and electron microscopy.


CONCLUSIONS
Through comparison of the four different treatment methods for metacresol burns, it is concluded that excision of the wound followed by skin grafting should be done as early as possible to minimize absorption of the chemical. Topical application of SD-Ag or sodium sulfate wet compress, and flushing with running water can alleviate direct injury to skin. Drugs to protect the heart, liver, and kidney should be used for a longer period than usual.
Wang
G
G
Hospital of Beijing Yanshan Petrochemical Corporation, Beijing 102500.
Jing
F
F
Su
S
S
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001806:Blood Urea Nitrogen; D002057:Burns, Chemical / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D003408:Cresols; D005260:Female; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D011817:Rabbits; D012837:Silver Sulfadiazine / Q000627:therapeutic use*
D003408:Cresols; D000410:Alanine Transaminase; C042041:3-cresol; D012837:Silver Sulfadiazine