Expression of midkine in the cochlea.
Midkine (MK) is one of a new family of heparin-binding growth factors involved in the regulation of growth and differentiation. We have analyzed expression of MK in the cochlea using ICR mice within 1 day from birth. The expression of MK in the cochlea was confirmed by Western blotting and immunohistochemistry. Anti-MK immunoreactivity was observed in the stria vascularis, spiral prominence, spiral ganglion, and ganglion nerve fibers. These findings suggest that MK plays a role in the development of the cochlea.
Jia
X Q
XQ
Department of Otorhinolaryngology, Nagoya University School of Medicine, Japan.
Nakashima
T
T
Kadomatsu
K
K
Muramatsu
T
T
D000818:Animals; D000831:Animals, Newborn; D015153:Blotting, Western; D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology; D003051:Cochlea / Q000254:growth & development / Q000378:metabolism*; D016207:Cytokines; D007150:Immunohistochemistry; D051379:Mice; D008813:Mice, Inbred ICR; D000078792:Midkine; D009412:Nerve Fibers / Q000378:metabolism; D009925:Organ of Corti / Q000378:metabolism; D013136:Spiral Ganglion / Q000378:metabolism; D013316:Stria Vascularis / Q000378:metabolism; D014018:Tissue Distribution
D002352:Carrier Proteins; D016207:Cytokines; D000078792:Midkine