Cytoskeleton-dependent transport and localization of mRNA.
Messenger RNAs are localized in both somatic and germ cells as a means of focusing the translation of proteins at specific cellular sites. The signals for this lie within the mRNA, and these are recognized by proteins in the cell. The latter appear to be attached via linker proteins to the transport machinery for localization. In some instances it is a myosin motor which translocates along actin microfilaments, and in others kinesin or dynein motors appear to be responsible for driving the movement of mRNA along microtubule substrates. The way that cytoskeleton-based mRNA translocation is regulated is speculated upon.
Stebbings
H
H
School of Biological Sciences, Washington Singer Laboratories, University of Exeter, United Kingdom.
D020413:3' Untranslated Regions; D000199:Actins / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D003599:Cytoskeleton / Q000378:metabolism*; D004268:DNA-Binding Proteins; D005656:Fungal Proteins / Q000378:metabolism; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D020409:Molecular Motor Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D012261:Ribonucleoproteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D020413:3' Untranslated Regions; D000199:Actins; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D020409:Molecular Motor Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D011993:Recombinant Fusion Proteins; D012261:Ribonucleoproteins; D014157:Transcription Factors; C490911:ASH1L protein, human; D011495:Histone-Lysine N-Methyltransferase