title: Neonatal purpura fulminans due to homozygous protein C deficiency.
abstract: Severe and recurrent purpura fulminans developed in a Turkish boy at 1 week of age. Initial coagulation studies performed were compatible with disseminated intravascular coagulation. Subsequent investigations showed that the patient had homozygous and his healthy parents had heterozygous protein C deficiency. The episodes of purpura fulminans were controlled by infusions of fresh frozen plasma and heparinization. Oral anticoagulant therapy was given in the symptom-free period.
authors.forename: U
authors.initials: U
authors.lastname: Ezer
authors.forename: E D
authors.initials: ED
authors.lastname: Misirlioglu
authors.forename: V
authors.initials: V
authors.lastname: Colba
authors.forename: E
authors.initials: E
authors.lastname: Ogoz
authors.forename: C
authors.initials: C
authors.lastname: Kurt
mesh_terms: D005192:Family Health; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000473:pathology / Q000628:therapy; D006720:Homozygote; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D007231:Infant, Newborn; D008297:Male; D020151:Protein C Deficiency / Q000150:complications* / Q000235:genetics; D014421:Turkey