Brain metastases of malignant melanoma showing unbalanced whole arm chromosomal translocations der (8; 14) (q10; q10) and der (11; 15) (q10; q10) in a Japanese patient.
Since malignant melanoma is a rare malignancy in Japan, little is known about the cytogenetic abnormalities in Japanese patients. We report a case of malignant melanoma showing complex chromosomal abnormalities. A 70-year-old woman was admitted to our hospital because of anorexia, delirium, and right hemiplegia. Cranial CT disclosed several metastatic brain tumors. Multiple subcutaneous and intra-abdominal metastases were also found. A diagnosis of metastatic malignant melanoma was made by biopsy of a subcutaneous tumor. Chromosomal analysis of the tumor cells disclosed complex karyotypic abnormalities including novel unbalanced whole arm translocations der (8; 14) (q10; q10) and der (11; 15) (q10; q10).
Takahashi
T
T
Second Department of Internal Medicine, Tenshi Hospital, Sapporo.
Kazama
Y
Y
Shimizu
H
H
Yoshimoto
M
M
Tsujisaki
M
M
Imai
K
K
D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000556:secondary*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D006801:Humans; D007564:Japan; D007621:Karyotyping; D008545:Melanoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000556:secondary*; D009382:Neoplasms, Unknown Primary / Q000235:genetics*; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic