title: [Psychotropic effects of alkaloid lappaconitine and its various derivatives].
abstract: The psychotropic activity of (I, base), its N-oxide, and a complex of the base with 18-alpha-H-glycyrrhizic acid (1:2) was studied. It was established that I and its N-oxide exhibit dopaminopositive effect whereas the complex produces a serotoninopositive effect. Toxicities of the lipophilic I is half that of the hydrophilic; toxicity of N-oxide and the complex are 60 and 100 times lower than the activity of lappaconitine (base).
authors.affiliation: Department of Natural and Biologically Active Compounds, Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr. akad. Lavrent'eva 9, Novosibirsk, 630090 Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: T V
authors.initials: TV
authors.lastname: Voevoda
authors.forename: M P
authors.initials: MP
authors.lastname: Dolgikh
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000157:Aconitine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001763:Blepharoptosis / Q000139:chemically induced; D018678:Cholinergic Agents / Q000494:pharmacology; D003497:Cyclic N-Oxides / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000037:antagonists & inhibitors; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000633:toxicity; D012110:Reserpine / Q000037:antagonists & inhibitors; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D018678:Cholinergic Agents; D003497:Cyclic N-Oxides; D011619:Psychotropic Drugs; D009538:Nicotine; D012110:Reserpine; D000109:Acetylcholine; D010433:Pentylenetetrazole; D000157:Aconitine; C022150:lappaconitine