title: Quality of life after treatment for advanced laryngeal and hypopharyngeal cancer.
abstract: OBJECTIVE
  To compare health-related quality of life measures after treatment for advanced (stages III and IV) laryngeal and hypopharyngeal cancers.
  
  
  METHODS
  Retrospective chart review and patient response to Health Status Questionnaire-12 (HSQ-12).
  
  
  METHODS
  Our study included 54 patients identified from the Tumor Registry of the University of Louisville Brown Cancer Center who were diagnosed and treated between 1995 and 2000. Demographics, tumor data, and treatment information were obtained from the Tumor Registry database. Questionnaires were mailed to all patients and included telephone follow-up. Comparative data and responses were analyzed for the 24 patients who responded to the survey.
  
  
  RESULTS
  Fifteen patients were treated with chemotherapy and radiation therapy (CRT). Six patients underwent surgery with postoperative radiation therapy (SRT). The remaining three patients were treated with radiation therapy but were not used in this analysis. The average follow-up was 35 months after treatment. The CRT and SRT groups were statistically similar regarding age, sex, duration of follow-up, tumor grade, and tumor stage. Laryngeal primary tumors were more common in the SRT group than in the CRT group (P =.005). Eight domains were assessed by the HSQ-12: physical functioning, role-physical, bodily pain, health perception, energy/fatigue, social functioning, role-mental, and mental health. No statistical differences were found between the CRT and SRT groups, except for role limitations attributable to physical health (P =.007).
  
  
  CONCLUSIONS
  These results indicate that only one of eight domains differs significantly between treatment groups when using the HSQ-12. Two-year survival end-point analysis of global health assessment may represent a simplified and meaningful way to compare treatment modalities in patients with advanced-stage head and neck cancer.
authors.affiliation: Division of Otolaryngology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, U.S.A.
authors.forename: M S
authors.initials: MS
authors.lastname: Major
authors.forename: J M
authors.initials: JM
authors.lastname: Bumpous
authors.forename: M B
authors.initials: MB
authors.lastname: Flynn
authors.forename: K
authors.initials: K
authors.lastname: Schill
mesh_terms: D003131:Combined Modality Therapy; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies