title: Serotonin mediated cluster headache, trigeminal neuralgia, glossopharyngeal neuralgia, and superior laryngeal neuralgia with SAD chronicity.
abstract: Cluster headache is a rare and severe pain syndrome with elusive pathophysiology. Serotonin pathways within the brainstem may be implicated in cluster headache with seasonal affective disorder and a subset of cranial nerve neuralgias. We describe and chronicle a syndrome consisting of cluster headache, seasonal affective disorder, with associated trigeminal, glossopharyngeal, superior laryngeal neuralgias in an 11-year-old female. Pharmacologic interventions for this patient were examined in conjunction with current classification, location and function of serotonin receptors. Etiology is postulated as mixed cranial nerve excitation via endogenous 5-HT (agonist) activity of 5-HT3 receptors within the nucleus tractus solitarius and trigeminal tract nucleus.
authors.affiliation: University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Weiss
authors.forename: K L
authors.initials: KL
authors.lastname: Weiss
authors.forename: S M
authors.initials: SM
authors.lastname: Benecke
mesh_terms: D003027:Cluster Headache / Q000150:complications* / Q000503:physiopathology; D003389:Cranial Nerve Diseases / Q000150:complications* / Q000503:physiopathology; D005260:Female; D020435:Glossopharyngeal Nerve Diseases / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007823:Laryngeal Nerves; D008297:Male; D011985:Receptors, Serotonin / Q000378:metabolism*; D016574:Seasonal Affective Disorder / Q000150:complications* / Q000503:physiopathology; D017552:Solitary Nucleus / Q000378:metabolism* / Q000503:physiopathology; D014277:Trigeminal Neuralgia / Q000150:complications / Q000503:physiopathology
chemical_list: D011985:Receptors, Serotonin