[Structural-functional status of the cardiomyocyte cell membrane under experimental pathology].
The results of research conducted on the cardiomyocytes plasma membranes structural and functional state under the experimental stress and atherosclerosis are displayed in this article. These experimental pathology is determined to be accompanied by some stereotypic quantitative and qualitative modifications occurred in the lipid matrix of the cardiomyocytes plasma membranes--increase of cholesterol content, decrease of phospholipids, accumulation of lisophospholipids and fatty acid. There are demonstrated results that the experimental stress has an atherogenic effect on the plasma membranes of cells by imputting the cholesterol into the membrane even in the intact animals with normal lipid metabolism. All these modifications are also accompanied by the activation of free-radical oxidation. All these changes are capable to lie in the basis of physical and chemical properties mechanism modification of membranes: modification of lipid matrix, change of viscosity, ion-transport properties of cardiomyocytes membranes, oppression of Na+, K(+)-ATPase activity.
Kuzmenko
O B
OB
National University of Kiev-Mohyla Academy, Kyiv.
Mkhitarian
L S
LS
Orlova
N M
NM
Evstratova
I N
IN
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005609:Free Radicals; D015227:Lipid Peroxidation; D008563:Membrane Lipids / Q000378:metabolism; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D013329:Structure-Activity Relationship
D005227:Fatty Acids; D005609:Free Radicals; D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol