[Molecular specificity of nafamostat mesilate (FUT), a drug used for the treatments of DIC and acute pancreatitis and as an anticoagulant--the pharmacodynamics and pharmacological action].
Pharmacokinetic studies of nafamostat mesilate (FUT) were reviewed in the previous report (Jpn J Cancer Chemother 27 (5): 767-774, 2000). In this report, the molecular specificity of FUT for these pharmacological behaviors were reviewed. In this study, it became clear that benzene ring inserted between ester-bond and guanidino group of the molecule and amidino group introduced in the opposite chain of guanidino group were found important for eliciting the molecular specificity of FUT.
Tsukagoshi
S
S
Cancer Institute, Japanese Foundation for Cancer Research.
D001550:Benzamidines; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy; D006146:Guanidines / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D011480:Protease Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*
D001550:Benzamidines; D006146:Guanidines; D011480:Protease Inhibitors; C032855:nafamostat