Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates.
A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).
McIntee
E J
EJ
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Wagner
C R
CR
D000135:Acid Phosphatase; D000577:Amides / Q000737:chemistry*; D002455:Cell Division; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000201:enzymology / Q000473:pathology; D009705:Nucleosides / Q000737:chemistry* / Q000378:metabolism*; D010756:Phosphoric Acids / Q000737:chemistry*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D013379:Substrate Specificity; D014407:Tumor Cells, Cultured
D000577:Amides; D004798:Enzymes; D009705:Nucleosides; D010756:Phosphoric Acids; C011067:phosphoramidic acid; D000135:Acid Phosphatase; C428439:prostatic acid phosphatase; D017027:Protein Tyrosine Phosphatases