Role of IL-18 in the secretion of Il-1beta, sIL-1RII, and IL-1Ra by human neutrophils.
In the present study we investigated the effect of IL- 18 on the production of IL-1beta, IL-1Ra and sIL-1RII by human neutrophils. Our observations indicate that rhIL-18 induces IL-1beta and, to a lesser extend, IL-1Ra and sIL-1RII production by human neutrophils isolated form peripheral blood. However, this effect was less important in comparison with LPS-stimulation. Moreover, the results obtained suggest that IL-18 can induce priming of neutrophils for IL-1beta and, to a lesser extend, IL- Ra and sIL-1RII production by LPS-stimulated cells. The capacity of IL-18 to serve as an effective modulator for IL-1beta and its regulatory proteins may have significance in the inflammatory and immune reactions mediated by IL-1beta.
Jablonska
E
E
Department of Immunopathology, Medical Academy of Bialystok, Poland. ewaj@amb.ac.bialystok.pl
Izycka
A
A
Jablonska
J
J
Wawrusiewicz
N
N
Piecuch
J
J
D018929:Cell Culture Techniques; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000378:metabolism*; D020382:Interleukin-18 / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D018375:Neutrophil Activation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D017472:Receptors, Interleukin-1 / Q000378:metabolism*; D053574:Receptors, Interleukin-1 Type II; D012795:Sialoglycoproteins / Q000378:metabolism*
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D020382:Interleukin-18; D008070:Lipopolysaccharides; D017472:Receptors, Interleukin-1; D053574:Receptors, Interleukin-1 Type II; D012795:Sialoglycoproteins