Long-term colchicine for recalcitrant palmoplantar pustulosis: treatment outcome in 3 patients.
Palmoplantar pustulosis (PPP) is a chronic, relapsing, pustular eruption affecting the palms and soles for which treatment is often difficult and frustrating. Short-term colchicine has been used to treat PPP with variable response. We report on the successful treatment of 3 patients with severe, therapy-resistant, chronic PPP. We observed significant reduction in the frequency of pustular eruptions and the number of pustules with maximum tolerable doses of colchicine treatment for up to 12 months.
Wong
S S
SS
National Skin Centre, Singapore. kysswong@yahoo.com
Tan
K C
KC
Goh
C L
CL
D000328:Adult; D003078:Colchicine / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects; D011565:Psoriasis / Q000188:drug therapy* / Q000517:prevention & control
D003879:Dermatologic Agents; D003078:Colchicine