Acute sensory ataxic neuropathy associated with monospecific anti-GD1b IgG antibody.
The authors describe two patients with acute sensory ataxic neuropathy. Both had a profound loss of proprioception and generalized areflexia. High titers of monospecific anti-GD1b IgG antibody were detected in their sera during the acute phase. Sensory ataxia resolved within 2 weeks after the onset. Taken together with the induction of experimental sensory ataxic neuropathy sensitized with GD1b ganglioside, GD1b may be a target molecule for autoantibody in some patients with acute sensory ataxic neuropathy.
Pan
C L
CL
Department of Neurology, National Taiwan University Hospital, Taipei.
Yuki
N
N
Koga
M
M
Chiang
M C
MC
Hsieh
S T
ST
D000208:Acute Disease; D000328:Adult; D000918:Antibody Specificity; D001259:Ataxia / Q000276:immunology*; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009475:Neurons, Afferent / Q000502:physiology
D005732:Gangliosides; D007074:Immunoglobulin G; C033851:ganglioside, GD1b