[Comparative analysis of multifollicular development with the application of recombinant FSH vs. urinary FSH in the results of in vitro fertilization].
The interactive function between intrafollicular factors related with ovum competence and embryo development played an important role getting high quality embryos during the embryo transference in in-vitro fertilization programs. Urinary gonadotropins are used widely to get homogeneous follicles during ovarian stimulation. Recombinant technology has been applied in these compounds to correlate with a best egg formation and higher pregnancy rates. We developed a prospective, linear and comparative study to aim the ovum/embryo development using urinary and recombinant FSH. A total of 100 patients were included in the study, 56 patients received rFSH (group I) and 44 hMG (group II). There were not differences in age, weight and body mass index as well as ovarian reserve. However, patients who used urinary gonadotrophins required a higher number of ampoules [31.7 +/- 8.6 vs. 20.7 +/- 6.4 (p < 0.001)]. No differences in peak E2, day of hCG and endometrial thickness. Although, no differences in number of egg mature, the fertilization rate was higher in the recombinant group [5.9 +/- 3.7 vs. 3.4 +/- 2.3 (p < 0.02)]. A higher number of embryo transfer were observed in the same group (3.4 +/- 1.7 vs. 1.9 +/- 2.2 (p < 0.004)]. The pregnancy rates were 34.3% and 29.6% for each group respectively.
Kably
A
A
Centro Especializado para la Atención de la Mujer, Unidad de Reproducción Asistida, División de Ginecología y Obstetricia, Hospital Angeles de las Lomas.
Castelazo
E
E
Barroso
G
G
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000494:pharmacology* / Q000652:urine*; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects* / Q000254:growth & development*; D011247:Pregnancy / Q000706:statistics & numerical data; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000494:pharmacology* / Q000652:urine*
D011994:Recombinant Proteins; D005640:Follicle Stimulating Hormone