N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents.
The synthesis, anti-Pneumocystis carinii activity and DNA binding properties of eight new N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 microM concentrations.
Huang
T L
TL
Xavier University of Louisiana, College of Pharmacy, New Orleans, LA 70125, USA. thuang@xula.edu
Tao
B
B
Quarshie
Y
Y
Queener
S F
SF
Donkor
I O
IO
D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011010:Pneumocystis / Q000187:drug effects
D000473:Alkanes; D000935:Antifungal Agents; D010879:Piperazines; D004247:DNA