title: Intracranial haemorrhage resulting from unsuspected choriocarcinoma metastasis.
abstract: A retrospective analysis of clinicopathological data of 10 patients with clinically unsuspected cerebral metastatic choriocarcinoma was carried out. All patients were young adult females. History of preceding pregnancy/abortion was forthcoming in 5 cases but none had a prior history of abnormal gestation. Features of raised intracranial tension followed by hemiparesis were the commonest presenting symptoms. A clinicoradiologic diagnosis of intracerebral haemorrhagic mass, either primary or secondary to tumour bleed, cortico-venous thrombosis or arteriovenous malformation, was entertained in 8 out of 10 cases. In other two cases, ring enhancing lesions prompted the diagnosis of granulomatous masses. Eight patients were operated upon, of whom two died after short hospital stay, and were autopsied. All had haemorrhagic masses noted at surgery/autopsy. Accurate diagnosis of metastatic choriocarcinoma was established only by histologic examination of these haemorrhages. This report emphasizes the importance of considering metastatic choriocarcinoma as an important differential diagnosis of haemorrhagic intracerebral lesions in women of child bearing age group. Measurement of serum/CSF level of HCG in suspected cases helps to implement early therapy. The diagnostic value of histopathologic examination of surgically resected blood clots in determining aetiology of intracerebral haemorrhagic masses is highlighted.
authors.affiliation: Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India.
authors.forename: T N
authors.initials: TN
authors.lastname: Suresh
authors.forename: V
authors.initials: V
authors.lastname: Santosh
authors.forename: V R
authors.initials: VR
authors.lastname: Shastry Kolluri
authors.forename: P N
authors.initials: PN
authors.lastname: Jayakumar
authors.forename: T C
authors.initials: TC
authors.lastname: Yasha
authors.forename: A
authors.initials: A
authors.lastname: Mahadevan
authors.forename: S K
authors.initials: SK
authors.lastname: Shankar
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000556:secondary*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D002822:Choriocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000556:secondary*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000150:complications* / Q000473:pathology*