title: c-erbB-3 proto-oncogene expression in uterine cervical carcinoma.
abstract: Over-expression of epidermal growth factor receptor (EGFR) and c-erbB-2, in uterine cervical carcinomas, is associated with a worsened prognosis. A third member of this proto-oncogene family, c-erbB-3, has now been identified and its over-expression has been described in a variety of carcinomas. In this immunohistochemical study we have shown that c-erbB-3 is widely expressed in cervical carcinomas, but we have found no association between its over-expression and lymph node status or clinical outcome. In a similar study examining the expression of EGFR and c-erbB-2 it was possible to demonstrate an association between over-expression and a worse prognosis. We conclude, therefore, that it is unlikely that demonstration of c-erbB-3 over-expression will be of any value as a prognostic indicator in carcinoma of the uterine cervix.
authors.affiliation: Department of Pathology, St Mary's Hospital, Manchester, Stepping Hill Hospital, Stockport, Bury General Hospital, ICRF Oncology Unit, Hammersmith Hospital, London, UK.
authors.forename: C.R.
authors.initials: CR
authors.lastname: Hunt
authors.forename: R.J.
authors.initials: RJ
authors.lastname: Hale
authors.forename: C.
authors.initials: C
authors.lastname: Armstrong
authors.forename: T.
authors.initials: T
authors.lastname: Rajkumar
authors.forename: W.J.
authors.initials: WJ
authors.lastname: Gullick
authors.forename: C.H.
authors.initials: CH
authors.lastname: Buckley