title: Histopathological studies on virulence of dipeptidyl aminopeptidase IV (DPPIV) of Porphyromonas gingivalis in a mouse abscess model: use of a DPPIV-deficient mutant.
abstract: To elucidate the role of dipeptidyl aminopeptidase IV (DPPIV) in the virulence of Porphyromonas gingivalis, mice were infected with either a wild-type strain or a DPPIV-deficient mutant using an abscess model. Histopathological analysis of the resulting lesions indicated that DPPIV participates in virulence through the destruction of connective tissue and the less effective mobilization of inflammatory cells.
authors.affiliation: Department of Pathology, Nippon Dental University, Fujimi 1-9-20, Chiyoda-ku, Tokyo 102-8159, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yagishita
authors.forename: Y
authors.initials: Y
authors.lastname: Kumagai
authors.forename: K
authors.initials: K
authors.lastname: Konishi
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Aoba
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000038:Abscess / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D000818:Animals; D016866:Bacteroidaceae Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D018819:Dipeptidyl Peptidase 4 / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D016966:Porphyromonas gingivalis / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D018819:Dipeptidyl Peptidase 4