Altered sexually dimorphic nucleus of the preoptic area (SDN-POA) volume in adult Long-Evans rats by dietary soy phytoestrogens.
Naturally occurring estrogen-like molecules in plants (phytoestrogens), present via soy, in animal diets can alter morphology and physiology in rodents. Phytoestrogens have the ability to bind estrogen receptors and exert many of the biological responses evoked by physiological estrogens. This study characterized the effects of dietary phytoestrogens on the expression of body and prostate weight, circulating testosterone and estradiol levels, puberty onset, vaginal cyclicity, and volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) in Long-Evans rats. Using different experimental protocols, animals were fed either a phytoestrogen-rich (Phyto-600) or a phytoestrogen-free (Phyto-free) diet. Animals fed the Phyto-600 diet displayed significantly decreased body weights (in males and females), prostate weights and delayed puberty in females compared to that of animals fed the Phyto-free diet. Circulating testosterone or estradiol levels in males or estrous cyclicity were not altered by the diets. The volume of the SDN-POA was significantly altered by a change in diet at 80 days of age where one-half of the males or females fed the Phyto-600 diet (from birth) were switched to the Phyto-free diet until 120 days of age. Males initially fed a Phyto-600 diet but changed to a Phyto-free diet had significantly smaller SDN-POA volumes compared to males fed the Phyto-600 diet (long-term). These data suggest that consumption of phytoestrogens via a soy diet, significantly: (1) decreases body and prostate weight, (2) delays puberty onset, and (3) alters SDN-POA volumes during adulthood.
Lund
T D
TD
The Neuroscience Center, Brigham Young University, Provo, UT 84602, USA.
Rhees
R W
RW
Setchell
K D
KD
Lephart
E D
ED
D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001284:Atrophy / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D048429:Cell Size / Q000187:drug effects / Q000502:physiology; D004967:Estrogens / Q000097:blood / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005526:Food, Formulated; D005835:Genitalia / Q000187:drug effects* / Q000378:metabolism; D007529:Isoflavones; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D048789:Phytoestrogens; D028321:Plant Preparations; D011301:Preoptic Area / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011467:Prostate / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D012727:Sex Characteristics; D013025:Glycine max / Q000737:chemistry; D013739:Testosterone / Q000097:blood / Q000378:metabolism
D004967:Estrogens; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D013739:Testosterone