[Operator activity and changes in the functional state of central adrenergic systems (a neurophysiological study)].
With a view to increasing the quality of prognosis of the effect of central adrenergic drugs upon the operator psychophysiological state and performance, we studied correlations between changes in the psychophysiological performance parameters and the spectral-coherent EEG characteristics in a group of 20 healthy volunteers after moderate enhancement or reduction of the central adrenergic system activity by yohimbine and pyrroxan. The two drugs produced a marked opposite influence (positive for yohimbine and negative for pyrroxan) upon the visual memory, attention, and visual signal analysis, which was correlated with opposing changes in the EEG characteristics, predominantly in the right hemisphere. This result must be taken into account in determining indications and co-unterindications for the particular drug administration to working operators.
Morozov
I S
IS
Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Vetliaeva
O A
OA
Barchukov
V G
VG
Salenko
Iu A
IuA
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D001288:Attention / Q000187:drug effects; D004146:Dioxanes / Q000494:pharmacology*; D004569:Electroencephalography; D006801:Humans; D009043:Motor Activity / Q000187:drug effects; D010775:Photic Stimulation; D011581:Psychological Tests; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D015016:Yohimbine; C009143:proroxan