[Effect of gamma-linolenic acid on microsomal oxidation in the rat liver following gamma-irradiation].
The antioxidant and radioprotector properties of gamma-linolenic acid isolated from the seeds of Borago officialis were studied on rats gamma-irradiated to a dose of 1 Gy. The irradiation caused an increase in the content of malonaldehyde in microsomal liver fraction and disturbed the metabolism of xenobiotics. The administration of gamma-linolenic acid in the form of a commercial drug Neoglandin (daily dose, 150 mg/kg, p.o.; over 1, 3, or 7 days after irradiation reduced the level of lipid peroxidation (for all treatment schedules), normalized the activity of NADPH-oxidase, NADH-oxidase, and NADPH-reductase, and increased the content of cytochromes P-450 and b5 as compared to bothirradiated and control animals.
Zavodnik
L B
LB
Laboratory of Experimental Hepatology, Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno, 230017 Belarus.
Sushko
L I
LI
Tarasov
Iu A
IuA
Ignatenko
K V
KV
Chumachenko
S S
SS
Ovchinnikov
V A
VA
Brzosko
V
V
Buko
V U
VU
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D029683:Borago; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015786:Cytochromes b5 / Q000378:metabolism; D004579:Electron Transport; D006900:Hydroxylation; D015227:Lipid Peroxidation; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D008517:Phytotherapy; D010938:Plant Oils / Q000627:therapeutic use; D011832:Radiation Injuries / Q000201:enzymology / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017965:gamma-Linolenic Acid / Q000494:pharmacology*
D000975:Antioxidants; D010938:Plant Oils; D011837:Radiation-Protective Agents; D017965:gamma-Linolenic Acid; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System