title: Difluorinated Danishefsky's diene: a versatile C(4) building block for the fluorinated six-membered rings.
abstract: [reaction: see text] A Mg(0)/Me(3)SiCl system was found to be effective for the preparation of difluoro Danishefsky's dienes 2, which involves selective C-F bond cleavage of trifluoromethyl ketones 3. Subsequent hetero Diels-Alder reactions of 2 with aldehydes and imines gave a variety of fluorinated six-membered heterocycles.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Amii
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Terasawa
authors.forename: K
authors.initials: K
authors.lastname: Uneyama