title: Adjunctive osteopathic manipulative treatment in women with depression: a pilot study.
abstract: The authors assessed the impact of osteopathic manipulative treatment (OMT) as an adjunct to standard psychiatric treatment of women with depression. Premenopausal women with newly diagnosed depression were randomly assigned to either control (osteopathic structural examination only; n = 9) or treatment group (OMT; n = 8). Both groups received conventional therapy consisting of the antidepressant paroxetine (Paxil) hydrochloride plus weekly psychotherapy for 8 weeks. Attending psychiatrists and psychologists were blinded to group assignments. No significant differences existed between groups for age or severity of disease. After 8 weeks, 100% of the OMT treatment group and 33% of the control group tested normal by psychometric evaluation. No significant differences or trends were observed between groups in levels of cytokine production (IL-1, IL-10, IL-2, IL-4, and IL-6) or in levels of anti-HSV-1, anti-HSV-2, and anti-EBV antibody. There was no pattern to the osteopathic manipulative structural dysfunctions recorded. The findings of this pilot study indicate that OMT may be a useful adjunctive treatment for alleviating depression in women.
authors.affiliation: Department of Microbiology, Chicago College of Osteopathic Medicine of Midwestern University, USA. Bplotk@Midwestern.edu
authors.forename: B J
authors.initials: BJ
authors.lastname: Plotkin
authors.forename: J J
authors.initials: JJ
authors.lastname: Rodos
authors.forename: R
authors.initials: R
authors.lastname: Kappler
authors.forename: M
authors.initials: M
authors.lastname: Schrage
authors.forename: K
authors.initials: K
authors.lastname: Freydl
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
authors.forename: E
authors.initials: E
authors.lastname: Hennegan
authors.forename: C
authors.initials: C
authors.lastname: Hilchie-Schmidt
authors.forename: D
authors.initials: D
authors.lastname: Hines
authors.forename: J
authors.initials: J
authors.lastname: Iwata
authors.forename: C
authors.initials: C
authors.lastname: Mok
authors.forename: D
authors.initials: D
authors.lastname: Raffaelli
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D003863:Depression / Q000145:classification / Q000188:drug therapy / Q000276:immunology / Q000534:rehabilitation*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008349:Manipulation, Orthopedic / Q000379:methods*; D008875:Middle Aged; D010021:Osteopathic Medicine / Q000379:methods*; D017374:Paroxetine / Q000627:therapeutic use; D010808:Physical Examination / Q000379:methods; D010865:Pilot Projects; D011446:Prospective Studies; D011594:Psychometrics; D011613:Psychotherapy; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine