title: Anticancer chemotherapy in a patient with prior history of acute intermittent porphyria. A case report and review of the literature.
abstract: We describe the case of a patient with a prior history of acute intermittent porphyria (AIP) who needed the administration of anticancer drugs. Our experience with this patient and the limited experience reported in the literature show that it is probably safe to administer some chemotherapeutic agents, but it is important to prevent (or to minimize) the toxicities of these chemotherapeutic agents, as they seem to put the patient at major risk of an AIP crisis. Hematin and supportive treatments were useful treatments in our patient.
authors.affiliation: Jules Bordet Institute, Chemotherapy Unit, Brussels, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Forget
authors.forename: A
authors.initials: A
authors.lastname: Awada
authors.forename: J
authors.initials: J
authors.lastname: Klastersky
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D017118:Porphyria, Acute Intermittent / Q000378:metabolism* / Q000652:urine; D011166:Porphyrins / Q000652:urine; D016896:Treatment Outcome
chemical_list: D011166:Porphyrins