Productive infection of primary macrophages with human herpesvirus 7.
Here we demonstrate replication of human herpesvirus 7 (HHV-7), a T-lymphotropic virus, in macrophages. Productive replication was lost after 2 weeks, but HHV-7 DNA was detected up to 1 month after infection. Thus, macrophages become infected by HHV-7 and might play an important role as a viral reservoir, as has been demonstrated for human immunodeficiency virus type 1.
Zhang
Y
Y
Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
de Bolle
L
L
Aquaro
S
S
van Lommel
A
A
De Clercq
E
E
Schols
D
D
D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis; D016199:Herpesvirus 7, Human / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000648:ultrastructure / Q000821:virology*; D008854:Microscopy, Electron; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014779:Virus Replication
D004279:DNA, Viral