title: Heart failure in pediatric septic shock: utilizing inotropic support.
abstract: Septic shock presents a unique challenge in the pediatric patient. Sepsis stimulates the release of inflammatory mediators that can compromise cardiac function. Oxygen extraction abnormalities, diminished responses to adrenergic agonists, and impaired ventricular function often result. After fluid resuscitation and antibiotic therapy, careful cardiovascular assessment is needed to administer appropriate inotropic and vasoactive drugs.
authors.affiliation: Cardiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. tabbutt@email.chop.edu
authors.forename: S
authors.initials: S
authors.lastname: Tabbutt
mesh_terms: D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D002303:Cardiac Output, Low / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D009202:Cardiomyopathies / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D012772:Shock, Septic / Q000150:complications* / Q000503:physiopathology; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D000318:Adrenergic beta-Agonists; D002316:Cardiotonic Agents; D010726:Phosphodiesterase Inhibitors; D014662:Vasoconstrictor Agents