Junceol A, a new sesquiterpenoid from the sea pen Virgularia juncea.
A new sesquiterpenoid, junceol A(1), as well as two known diterpenoids, sclerophytin A (2) and cladiellisin (3), have been isolated from the sea pen octocoral Virgularia juncea. The structure of metabolite 1 was determined by extensive spectral analysis. Compounds 1-3 have been shown to exhibit cytotoxicity toward P-388 cancer cells.
Chen
S P
SP
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
Sung
P J
PJ
Duh
C Y
CY
Dai
C F
CF
Sheu
J H
JH
D000818:Animals; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003063:Cnidaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
D001952:Bridged-Ring Compounds; D005663:Furans; D012717:Sesquiterpenes; C438428:junceol A; C412667:sclerophytin A