[Oxygen deficiency and erythropoietin].
Reduced oxygenation activates specific expression of erythropoietin (EPO) and other hypoxia-regulated genes. The cellular response to hypoxia is mediated by the hypoxia-inducible factor-1 (HIF-1). Unregulated overexpression of EPO results in a hematocrit value of about 80%; transgenic mice were shown to adapt to this polyglobulia.
Gassmann
M
M
Physiologisches Institut der Universität Zürich. maxg@access.unizh.ch
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004921:Erythropoietin / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D005786:Gene Expression Regulation / Q000502:physiology*; D006400:Hematocrit / Q000662:veterinary; D000860:Hypoxia / Q000503:physiopathology / Q000662:veterinary*; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051379:Mice; D008822:Mice, Transgenic; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C497443:Hif1a protein, mouse; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014157:Transcription Factors; D004921:Erythropoietin; D010100:Oxygen