title: Intracerebroventricular injection of pipecolic acid inhibits food intake and induces sleeping-like behaviors in the neonatal chick.
abstract: It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-Lysine (L-Lys) in the brain, is involved in the functioning of Gamma-aminobutyric acid. In the present work the effect of intracerebroventricular (i.c.v.) administration of L-PA, and its relatives, on food intake and behavior in neonatal chicks was investigated. The i.c.v. injection of 1 mg of L-PA and D-PA significantly inhibited food intake during the 2 h following injection, whereas greater than 2 mg of L-Lys was required to inhibit food intake. In behavioral tests, the i.c.v. injection of L-PA reduced active wakefulness and feeding behavior while inducing sleeping-like behavior in chicks. These results suggest that L-PA has an important role for the regulation of behaviors in the neonatal chick after conversion from L-Lys in the brain.
authors.affiliation: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: R
authors.initials: R
authors.lastname: Ando
authors.forename: A
authors.initials: A
authors.lastname: Ohgushi
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: E
authors.initials: E
authors.lastname: Dobashi
authors.forename: H
authors.initials: H
authors.lastname: Hussain-Yusuf
authors.forename: R
authors.initials: R
authors.lastname: Onodera
authors.forename: T
authors.initials: T
authors.lastname: Bungo
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000502:physiology; D002645:Chickens; D004435:Eating / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D010875:Pipecolic Acids / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*
chemical_list: D010875:Pipecolic Acids; C031345:pipecolic acid