Effects of selected minerals on leptin secretion in streptozotocin-induced hyperglycemic mice.
The effects of lithium, magnesium, vanadate, and zinc on leptinemia and leptin secretion by adipose tissue were investigated in streptozotocin- (STZ) induced hyperglycemic mice. After the administration of studied minerals in drinking water for 4 weeks, fasting serum leptin concentrations were elevated, accompanied by normoglycemia in STZ-injected mice, regardless which mineral was provided (P < 0.05). However, the in vitro administration of lithium, magnesium, and vanadate did not significantly influence the leptin secretion of adipose tissue. A low zinc treatment (0.1 mM) augmented, whereas both a pharmacological treatment of zinc (1 mM) and zinc depletion (1 mM TPEN) attenuated, leptin secretion (P < 0.05). The present study shows that STZ-induced hyperglycemic mice have hypoleptinemia and reduced leptin secretion by adipose tissue. Moreover, these defects can be improved by a moderate zinc administration.
Chen
M D
MD
Department of Medical Laboratories, Taichung Veterans General Hospital, 160 Taichung-Kang Road, Section 3, Taichung 40705, Taiwan.
Yang
V C
VC
Alexander
P S
PS
Lin
P Y
PY
Song
Y M
YM
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism*; D015850:Interleukin-6 / Q000096:biosynthesis; D007773:Lactates / Q000378:metabolism; D020738:Leptin / Q000378:metabolism*; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008903:Minerals / Q000008:administration & dosage / Q000494:pharmacology*; D013311:Streptozocin; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014638:Vanadates / Q000008:administration & dosage / Q000494:pharmacology; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology
D001786:Blood Glucose; D015850:Interleukin-6; D007773:Lactates; D020738:Leptin; D008903:Minerals; D014409:Tumor Necrosis Factor-alpha; D014638:Vanadates; D013311:Streptozocin; D008094:Lithium; D008274:Magnesium; D015032:Zinc