title: Potent, low molecular weight thrombin receptor antagonists.
abstract: Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC(50) of 33 nM.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA. samuel.chackalamannil@spcorp.com
authors.forename: S
authors.initials: S
authors.lastname: Chackalamannil
authors.forename: D
authors.initials: D
authors.lastname: Doller
authors.forename: K
authors.initials: K
authors.lastname: Eagen
authors.forename: M
authors.initials: M
authors.lastname: Czarniecki
authors.forename: H S
authors.initials: HS
authors.lastname: Ahn
authors.forename: C J
authors.initials: CJ
authors.lastname: Foster
authors.forename: G
authors.initials: G
authors.lastname: Boykow
mesh_terms: D008970:Molecular Weight; D018179:Receptors, Thrombin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D018179:Receptors, Thrombin