title: Infections of the central nervous system of suspected viral origin: a collaborative study from Finland.
abstract: We studied 3231 patients with acute central nervous system (CNS) symptoms of suspected viral origin to elucidate the current etiologic spectrum. In 46% of the cases, a viral finding was observed. Varicella-zoster virus (VZV) was the main agent associated with encephalitis, as well as meningitis and myelitis. VZV comprised 29% of all confirmed or probable etiologic agents. Herpes simplex virus (HSV) and enteroviruses accounted 11% each, and influenza A virus 7%. VZV seems to have achieved a major role in viral infections of CNS. In encephalitis in our population, VZV is clearly more commonly associated with these neurological diseases than HSV. The increase in VZV findings may in part be a pseudophenomenon due to improved diagnostic methods, however, a true increase may have occurred and the pathogenetic mechanisms behind this should be elucidated.
authors.affiliation: The Haartman Institute, Department of Virology, University of Helsinki, Finland. Marjaleena.Koskiniemi@Helsinki.FI
authors.forename: M
authors.initials: M
authors.lastname: Koskiniemi
authors.forename: T
authors.initials: T
authors.lastname: Rantalaiho
authors.forename: H
authors.initials: H
authors.lastname: Piiparinen
authors.forename: C H
authors.initials: CH
authors.lastname: von Bonsdorff
authors.forename: M
authors.initials: M
authors.lastname: Färkkilä
authors.forename: A
authors.initials: A
authors.lastname: Järvinen
authors.forename: E
authors.initials: E
authors.lastname: Kinnunen
authors.forename: S
authors.initials: S
authors.lastname: Koskiniemi
authors.forename: L
authors.initials: L
authors.lastname: Mannonen
authors.forename: M
authors.initials: M
authors.lastname: Muttilainen
authors.forename: K
authors.initials: K
authors.lastname: Linnavuori
authors.forename: J
authors.initials: J
authors.lastname: Porras
authors.forename: M
authors.initials: M
authors.lastname: Puolakkainen
authors.forename: K
authors.initials: K
authors.lastname: Räihä
authors.forename: E M
authors.initials: EM
authors.lastname: Salonen
authors.forename: P
authors.initials: P
authors.lastname: Ukkonen
authors.forename: A
authors.initials: A
authors.lastname: Vaheri
authors.forename: V
authors.initials: V
authors.lastname: Valtonen
mesh_terms: D000257:Adenoviridae Infections / Q000453:epidemiology / Q000821:virology; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002690:Chlamydia Infections / Q000453:epidemiology; D016993:Chlamydophila pneumoniae; D004660:Encephalitis / Q000453:epidemiology / Q000382:microbiology; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis / Q000453:epidemiology; D004675:Encephalitis, Tick-Borne / Q000453:epidemiology / Q000821:virology; D020804:Encephalitis, Varicella Zoster / Q000175:diagnosis; D018792:Encephalitis, Viral / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D004769:Enterovirus Infections / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005387:Finland / Q000453:epidemiology; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007124:Immunoenzyme Techniques; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008581:Meningitis / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D008875:Middle Aged; D009187:Myelitis / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D029262:Puumala virus / Q000302:isolation & purification; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology; D016036:Seroepidemiologic Studies; D014611:Vaccination; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines