title: Differential diagnosis of large-sized pedunculated polypoid lesions of the gallbladder by endoscopic ultrasonography: a prospective study.
abstract: OBJECTIVE
  We have previously reported the effectiveness of endoscopic ultrasonography (EUS) for the differential diagnosis of pedunculated polypoid lesions of the gallbladder, based on retrospective studies using resected specimens. We proposed the following diagnostic criteria for EUS findings: when the contour of a lesion is nodular or smooth, the lesion is diagnosed as a neoplasm, and when a lesion has a granular contour, it is diagnosed as a nonneoplasm. The present study was designed to verify the clinical utility of our EUS ctiteria prospectively.
  
  
  METHODS
  Forty-six consecutive patients with pedunculated polypoid lesions of the gallbladder 10mm or greater in size diagnosed as nonneoplasms at the initial EUS, all of whom underwent follow-up examinations, were enrolled in this study. The occurrence of changes in these lesions during the observation period was examined.
  
  
  RESULTS
  No evident changes in lesions were observed in 43 of the 46 patients. Spontaneous self-detachment of lesions was recognized during the observation period in the other 3 patients.
  
  
  CONCLUSIONS
  EUS is useful for determining treatment indications for pedunculated polypoid lesions of the gallbladder, even when the lesions are large, and contributes to avoiding unnecessary surgery.
authors.affiliation: Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Noda
authors.forename: G
authors.initials: G
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Ito
mesh_terms: D018256:Adenomatous Polyps / Q000000981:diagnostic imaging* / Q000601:surgery; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D019160:Endosonography / Q000379:methods; D005260:Female; D005706:Gallbladder Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity