title: Late recurrence of a primitive neuro-ectodermal tumor.
abstract: Late recurrences after therapy are rare in primitive neuro-ectodermal tumor (PNET). Most recurrences occur within the first 2 years after therapy, although a small number of recurrences may occur up to 5 years after therapy. We present a rare case of a recurrence of PNET in a 31-year-old woman 17 years after her initial presentation. The potential biological implications of this late recurrence as well as responses to subsequent therapy, including temozolomide, are discussed.
authors.affiliation: Department of Medicine, University of Wisconsin, Madison, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Rao
authors.forename: H I
authors.initials: HI
authors.lastname: Robins
authors.forename: M P
authors.initials: MP
authors.lastname: Mehta
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D002528:Cerebellar Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D002574:Cervical Vertebrae; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004388:Dura Mater; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008161:Lumbosacral Region; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D009363:Neoplasm Proteins / Q000032:analysis; D018242:Neuroectodermal Tumors, Primitive / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D010871:Pinealoma / Q000473:pathology* / Q000532:radiotherapy; D016634:Radiosurgery; D012074:Remission Induction; D012585:Sciatica / Q000209:etiology; D013125:Spinal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D016708:Synaptophysin / Q000032:analysis; D000077204:Temozolomide; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D018906:Antineoplastic Agents, Alkylating; D014408:Biomarkers, Tumor; D007527:Isoenzymes; D009363:Neoplasm Proteins; D016708:Synaptophysin; D014750:Vincristine; D003606:Dacarbazine; D003520:Cyclophosphamide; D000469:Alkaline Phosphatase; D010751:Phosphopyruvate Hydratase; D002945:Cisplatin; D000077204:Temozolomide