Unlocking mysteries of gut sensory transmission: is adenosine the key?
Endogenous adenosine acts at pre- or postsynaptic A1, A2, or A3 receptors to inhibit synaptic transmission in intrinsic primary afferent/AH neurons, S neurons, and mucosal and motility reflexes. Adenosine provides dual modulation of adenylyl cyclases. Its modulation of sensory transmission may be of therapeutic potential in gut inflammation, ischemia, and constipation.
Christofi
F L
FL
Department of Anesthesiology, Physiology, and Cell Biology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA.
D000241:Adenosine / Q000502:physiology*; D000818:Animals; D017615:Enteric Nervous System / Q000166:cytology / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D017833:Visceral Afferents / Q000502:physiology*
D000241:Adenosine