HLA class II DR-DQ and increased risk of cervical cancer among Senegalese women.
To examine Senegalese women to confirm and extend associations between HLA class II types and cervical cancer previously observed among African-American, Caucasian, Hispanic, and Japanese ethnic populations, 55 Senegalese women with invasive cervical carcinoma were compared with age-matched (human papillomavirus) HPV-positive (n = 83) and HPV-negative (n = 107) control women. PCR-based HPV and HLA typing methods were used. Data were analyzed using a global randomization test and conditional logistic regression. Although this study failed to confirm a previously reported association between cervical cancer and DQB1*03 alleles, the DRB1*1101-DQB1*0301 haplotype was detected more frequently among cervical carcinoma cases than among controls (adjusted odds ratio, 2.6; 95% confidence interval, 1.0-7.1). Furthermore, as reported by others, we observed a negative association of borderline statistical significance between DRB1*13 and cervical carcinoma (adjusted odds ratio, 0.5; 95% confidence interval, 0.2-1.1). Observations from this study confirm earlier findings of a negative association between DRB1*13 and cervical cancer and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for cervical cancer.
Lin
P
P
Department of Epidemiology, University of Washington, Seattle, 98195, USA.
Koutsky
L A
LA
Critchlow
C W
CW
Apple
R J
RJ
Hawes
S E
SE
Hughes
J P
JP
Touré
P
P
Dembele
A
A
Kiviat
N B
NB
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006683:HLA-DQ Antigens / Q000235:genetics*; D015802:HLA-DR2 Antigen / Q000235:genetics*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D012016:Reference Values; D018570:Risk Assessment; D012494:Sampling Studies; D012675:Senegal / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology
D005819:Genetic Markers; D006683:HLA-DQ Antigens; D015802:HLA-DR2 Antigen