title: Ultrasonographic assessment of coronary flow reserve and abdominal fat in obesity.
abstract: Recent technological advances in transthoracic Doppler echocardiography (TTDE) have provided noninvasive measurement of coronary flow velocity reserve (CFVR). We aimed to quantitate a correlation between endothelial dysfunction and fat distribution. In 36 patients with obesity, 16 with noninsulin-dependent diabetes mellitus (DM) and 12 healthy volunteers, coronary flow velocity was measured at the distal site of the left anterior descending branch. CFVR was defined as the ratio of hyperemic (IV infusion of 0.15 mg/kg/min adenosine) to basal peak diastolic flow velocity. Abdominal wall fat index (AWFI) was estimated by ultrasonography. Insulin resistance was quantified by the euglycemic hyperinsulinemic clump method. AWFI was significantly related to CFVR (r = -0.46, p = 0.011) and insulin resistance (r = -0.71, p < 0.0001). CFVR could be noninvasively evaluated using TTDE. Coronary endothelial dysfunction indicated as CFVR, body fat distribution and insulin resistance was quantitatively correlated in obesity.
authors.affiliation: The Second Department of Internal Medicine, Kagawa Medical University, Kagawa, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Mizushige
authors.forename: K
authors.initials: K
authors.lastname: Hirao
authors.forename: S
authors.initials: S
authors.lastname: Nozaki
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
authors.forename: H
authors.initials: H
authors.lastname: Masugata
authors.forename: M
authors.initials: M
authors.lastname: Kohno
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D017667:Adipocytes / Q000000981:diagnostic imaging; D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D000368:Aged; D000704:Analysis of Variance; D001161:Arteriosclerosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002306:Cardiac Volume / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology*; D018618:Echocardiography, Doppler, Color; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology