SUVi and BACH1: a new subfamily of mammalian helicases?
The RecQ family of DNA helicases have been shown to be important for the maintenance of genomic integrity in prokaryotes and eukaryotes. Members of this family are genes responsible for cancer predisposition disorders like Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome. Here, we show the sequence homologies between two recently identified mammalian helicases, namely SUVi and BACH1. These two genes also share strong homologies with other members of the RecQ family. On the basis of published data and sequence analysis we suggest that SUVi/BACH1 may represent a novel subfamily of mammalian helicases, functioning in the processing of lesions induced by different genotoxic agents.
Menichini
P
P
Laboratory of Mutagenesis, National Cancer Research Institute IST, Largo R. Benzi 10, 16132, Genova, Italy. menikini@hp380.ist.unige.it
Linial
M
M
D000595:Amino Acid Sequence; D000818:Animals; D016466:CHO Cells; D018797:Cell Cycle Proteins; D006224:Cricetinae; D004265:DNA Helicases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins; D051856:Fanconi Anemia Complementation Group Proteins; D008969:Molecular Sequence Data; D020365:RNA Helicases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D051856:Fanconi Anemia Complementation Group Proteins; C421222:SUVi protein, Cricetulus griseus; D004265:DNA Helicases; C000618935:BRIP1 protein, human; D020365:RNA Helicases