Membrane current possessing the properties of a mechano-electric transducer current in inner hair cells of guinea-pig cochlea.
We measured the membrane current possessing the properties of a mechano-electric transducer current in isolated inner hair cells of guinea-pig cochlea. In a free-standing hair bundle, depolarization to +80 mV evoked a stable outward current attributable to the opening of transducer channels, and repolarization to -80 mV evoked a transient inward current indicating adaptation. The time constant of adaptation increased as the membrane potential depolarized. Dihydrostreptomycin diminished both the outward and inward currents.
Kimitsuki
T
T
Department of Otorhinolaryngology, Miyazaki Medical College, 5200 Kihara, Kiyotake-cho, Miyazaki 889-1692, Japan. kimituki@fc.miyazaki-med.ac.jp
Nishida
M
M
Kawano
H
H
Haruta
A
A
Matsuda
K
K
Komune
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D004096:Dihydrostreptomycin Sulfate / Q000494:pharmacology; D004558:Electric Stimulation; D006168:Guinea Pigs; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects / Q000378:metabolism*; D006309:Hearing / Q000187:drug effects / Q000502:physiology; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D000900:Anti-Bacterial Agents; D007473:Ion Channels; D004096:Dihydrostreptomycin Sulfate