[Determination of permeation of ketoprofen across the skin in vitro by second order derivative spectrophotometry].
A second order derivative spectrophotometric method was developed for the permeative determination of ketoprofen in vitro. The method can avoid the disturbance of skin tissue. The procedure is simple and rapid. The results are accurate. The mean recovery of ketoprofen is 99.00% +/- 1.51%.
Hu
J H
JH
Department of Pharmacy, Changhai Hospital, Shanghai 200433.
Zhu
Y
Y
Xue
P H
PH
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000493:pharmacokinetics; D007660:Ketoprofen / Q000032:analysis / Q000493:pharmacokinetics*; D051379:Mice; D012869:Skin Absorption / Q000187:drug effects*; D013053:Spectrophotometry / Q000379:methods
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen