title: Oxytetracycline residues in giant freshwater prawn (Macrobrachium rosenbergii).
abstract: The distribution of oxytetracycline (OTC) in male and female Macrobrachium rosenbergii was examined after the prawns had been given medicated feed containing OTC at levels of 2.5 and 5.0 g/kg of feed for 1 week and nonmedicated feed thereafter. OTC levels in the heads of both male and female prawns were consistently higher than in the muscles. Batches of both male and female prawns treated with higher dosages had significantly higher OTC residues in both head and muscle tissues than the batches treated with lower dosages. During treatment, peak concentrations in the head and muscle from each group were reached within 4-6 days. After drug treatment ceased, 13 days for the head and 10 days for the muscle were required to reduce OTC residues to safe levels in all batches of both sexes and dosages. In practice, to account for variations in water temperature, drug dosage, duration of therapy, and other environmental conditions, a withdrawal period of 21 days is recommended.
authors.affiliation: Fish Inspection and Quality Control Division, Samutsakhon Coastal Aquaculture Development Center, Department of Fisheries, Kaset-Klang, Chattuchak, Bangkok 10900, Thailand. supapunb@fisheries.go.th
authors.forename: S
authors.initials: S
authors.lastname: Brillantes
authors.forename: V
authors.initials: V
authors.lastname: Tanasomwang
authors.forename: S
authors.initials: S
authors.lastname: Thongrod
authors.forename: N
authors.initials: N
authors.lastname: Dachanantawitaya
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D006257:Head; D008297:Male; D009132:Muscles / Q000737:chemistry; D010118:Oxytetracycline / Q000032:analysis*; D033541:Palaemonidae / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D010118:Oxytetracycline