Comparative genomic analysis of genes encoding translation elongation factor 1B(alpha) in human and mouse shows EEF1B1 to be a recent retrotransposition event.
We have characterized genomic loci encoding translation elongation factor 1B(alpha) (eEF1B(alpha)) in mice and humans. Mice have a single structural locus (named Eef1b2) spanning six exons, which is ubiquitously expressed and maps close to Casp8 on mouse chromosome 1, and a processed pseudogene. Humans have a single intron-containing locus, EEF1B2, which maps to 2q33, and an intronless paralogue expressed only in brain and muscle (EEF1B3). Another locus described previously, EEF1B1, is actually a processed pseudogene on chromosome 15 corresponding to an alternative splice form of EEF1B2. Our study illustrates the value of comparative mapping in distinguishing between processed pseudogenes and intronless paralogues.
Chambers
D M
DM
Medical Genetics Section, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Rouleau
G A
GA
Abbott
C M
CM
D017398:Alternative Splicing; D000818:Animals; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D005091:Exons; D020224:Expressed Sequence Tags; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D006801:Humans; D007438:Introns; D051379:Mice; D020648:Peptide Elongation Factor 1 / Q000235:genetics*; D011544:Pseudogenes
D020662:Guanine Nucleotide Exchange Factors; D020648:Peptide Elongation Factor 1; C000599473:eEF1B-alpha protein, human