Triiodothyronine augmentation for the treatment of depression in substance misusers unresponsive to tricyclic antidepressants.
We report on two substance misusers with depression resistant to tricyclic antidepressant treatment who responded to triiodothyronine augmentation. The management of resistant depression, augmentation strategies with particular reference to triiodothyronine, and the possible mechanism of action of triiodothyronine are discussed.
Kan
C K
CK
Department of Psychiatry, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong.
Ho
T P
TP
D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders / Q000150:complications*; D014284:Triiodothyronine / Q000627:therapeutic use*
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D014284:Triiodothyronine