[Changes in lipid profiles in women after surgical castration during the fertile age].
OBJECTIVE
The main known risk factors for coronary heart disease in women, other than age, which is the most important risk factor of all, are cigarette smoking, raised blood pressure, obesity, diabetes and premature menopause, especially after ovarectomy.


METHODS
Retrospective clinical study.


METHODS
Medical building, Prague 7, Department of Obstetrics and Gynecology 3rd Medical Faculty Charles University and Faculty Hospital Vinohrady, Prague 10.


METHODS
In 1995 and 1996 we investigated plasma lipid levels and bone density in 75 women, 3 to 5 years after ovarectomy without HRT (group A). The results were compared with a control group (group B) of women of the same age and BMI. This group of women had normal menstruation periods. We investigated age, body mass index, bone density, total cholesterol, HDL and LDL cholesterol, ateroghenic index and triglycerides.


RESULTS
When we compared groups A and B, there was a better result in all serum lipid levels in group B, but not significantly. In group A was more women with patological level of HDL-cholesterol. In group A there was a significantly lower level of bone density than in group B and there was an increase in the number of patients with osteoporosis in this group.


CONCLUSIONS
Castration in premenopause had no influence in mean levels of parameters of lipid metabolism, but bone density significantly decreased after castration in this period.
Jenícek
J
J
Lékarský dům Praha 7.
Bendová
M
M
Dohnalová
A
A
D015992:Body Mass Index; D015519:Bone Density; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008594:Menopause, Premature / Q000097:blood*; D008875:Middle Aged; D010052:Ovariectomy; D012189:Retrospective Studies
D008055:Lipids