title: Diagnostic efficacy of tumor markers, sonography, and intraoperative frozen section for ovarian tumors.
abstract: Using sonography, we classified the adnexal masses of 292 patients into 4 patterns. Pattern A was benign cystic tumors; B was benign mixed tumors (cysts with a smooth solid component); C was malignant mixed tumors (cysts with an irregular solid component or thickened septum), and D was solid tumors. We diagnosed tumors showing patterns A and B as benign, while patterns C and D represented tumors with low malignant potential or actual malignancy. The sensitivity and specificity of sonography was 82.2 and 82.1%, respectively, and these values were superior to those for tumor markers (CA125, CA19-9, CA72-4). Both the sensitivity and specificity of intraoperative frozen sections were the highest, showing that this is the most reliable examination. However, 15 of 191 patients undergoing frozen section were upgraded by the final pathological diagnosis. If sonography is performed by an experienced gynecologic oncologist, this examination is more reliable than tumor markers. However, intraoperative frozen section should still be performed during surgery for patients with ovarian tumors.
authors.affiliation: Department of Obstetrics and Gynecology, Narita Hospital, Narita, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Wakahara
authors.forename: F
authors.initials: F
authors.lastname: Kikkawa
authors.forename: A
authors.initials: A
authors.lastname: Nawa
authors.forename: K
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: K
authors.initials: K
authors.lastname: Ino
authors.forename: O
authors.initials: O
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Kawai
authors.forename: S
authors.initials: S
authors.lastname: Mizutani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005629:Frozen Sections; D006651:Histocytochemistry; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D012372:ROC Curve; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; C083825:CA-72-4 antigen