[Intracellular disorders in the dog myocardium in low cardiac output syndrome caused by massive hemorrhage, approaches to correction].
It was shown on dog experiments that disorders in the phosphorylation-proteolysis-calcium transport system in the sarcoplasmatic reticulum of pathologically changed myocardium are an important component of cardiac activity depression in massive blood loss. Low cardiac output can be corrected by ammonium molibdate, phosphoprotein phosphatase inhibitor, and contrycal, proteolysis inhibitor.
Dizhe
A A
AA
Levshankov
A I
AI
Krasovskaia
I E
IE
Dizhe
G P
GP
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004396:Coloring Agents / Q000627:therapeutic use*; D004285:Dogs; D006470:Hemorrhage / Q000150:complications; D006490:Hemostatics / Q000627:therapeutic use*; D008962:Models, Theoretical; D008982:Molybdenum / Q000627:therapeutic use*; D009206:Myocardium / Q000166:cytology*; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use*; D014361:Trypsin Inhibitors / Q000627:therapeutic use*
D004396:Coloring Agents; D006490:Hemostatics; D015842:Serine Proteinase Inhibitors; D014361:Trypsin Inhibitors; D008982:Molybdenum; D007611:Aprotinin; D010749:Phosphoprotein Phosphatases; C022175:ammonium molybdate