[Recurrent chancriform mucous membrane ulcer in plasmacytoma with secondary IgA deficiency. Pyoderma chancriforme of the tongue].
A 66 year old patient presented with a nine month history of recurrent oral ulcerations involving the tongue. We diagnosed chancriform pyoderma and a previously not identified multiple myeloma with secondary immunoglobulin deficiency. Clinically and histologically we excluded a necrotizing ulcerative stomatitis as found in individuals with cellular immunodeficiency as in late-stage HIV-infection. On culture only Neisseria catarrhalis was found. Chancriform pyoderma is often associated with local bacterial infections, especially Staphylococcus aureus. The most common sites are the genitalia and periorbital region; involvement of the oral mucosa is uncommon. To the best of our knowledge, this is the fourth reported case with tongue lesions. The multiple myeloma-associated immunoglobulin deficiency might have facilitated the oral manifestations of chancriform pyoderma.
Hegemann
B
B
Universitätsklinik und Poliklinik für Dermatologie und Venerologie der Martin-Luther-Universität Halle-Wittenberg, Ernst-Kromayer-Strasse 5-6, 06097 Halle/Saale. bemd.hegemann@medizin.uni-halle.de
Helmbold
P
P
Dickert
C
C
Marsch
W C
WC
D000368:Aged; D002602:Chancroid / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D005928:Glossitis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D017098:IgA Deficiency / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000473:pathology; D019226:Oral Ulcer / Q000175:diagnosis* / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D014059:Tongue / Q000473:pathology