title: Highly active antiretroviral therapy induces specific changes in effector and central memory T cell sub-populations.
abstract: Highly active antiretroviral therapy (HAART) improves the immunodeficiency of HIV-infected individuals. In this report we show that HAART increases both naive (CD45RA+CD62L+) and central memory (CD45RO+CD62L+) CD4 lymphocytes. On CD8 lymphocytes, HAART induces an increase of naive cells associated with a consistent decrease of effector cells (CD45 RO+CD62L-). No specific differences in phenotypic changes were observed with different HAART regimens, suggesting that, once viral suppression is achieved, the pharmacological class of antiretroviral drugs does not affect immune reconstitution.
authors.affiliation: Service of Clinical Immunology, Department of Internal Medicine, Ancona University Medical School, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Muñoz-Calleja
authors.forename: A
authors.initials: A
authors.lastname: Costantini
authors.forename: G
authors.initials: G
authors.lastname: Silvestri
authors.forename: L
authors.initials: L
authors.lastname: Butini
authors.forename: C M
authors.initials: CM
authors.lastname: Regnery
authors.forename: S
authors.initials: S
authors.lastname: Mancini
authors.forename: M
authors.initials: M
authors.lastname: Montroni
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D007156:Immunologic Memory / Q000187:drug effects*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology