Association between cyclohexane resistance in Salmonella of different serovars and increased resistance to multiple antibiotics, disinfectants and dyes.
A panel of 388 salmonellas of animal and human origin, comprising 35 serotypes, was tested for resistance to cyclohexane and to a range of antibiotics, disinfectants and dyes. Cyclohexane resistance was detected in 41 isolates (10.6%): these comprised members of the serovars Binza (1 of 15), Dublin (1 of 24), Enteritidis (1 of 61), Fischerkietz (4 of 5), Livingstone (9 of 11), Montevideo (1 of 32), Newport (4 of 23), Saint-paul (1 of 3), Senftenberg (10 of 24) and Typhimurium (9 of 93). Most (39 of 41) of the cyclohexane-resistant isolates were from poultry. Statistical analysis showed that the cyclohexane-resistant strains were significantly more resistant than the cyclohexane-susceptible strains to ampicillin, chloramphenicol, ciprofloxacin, erythromycin, nalidixic acid, tetracycline, trimethoprim, cetrimide and triclosan. The multiresistance patterns seen were typical of those caused by efflux pumps, such as AcrAB. The emergence of such resistance may play an important role in the overall antibiotic resistance picture of Salmonella, with particular effect on ciprofloxacin.
Randall
Luke P
LP
Veterinary Laboratories Agency (Weybridge), New Haw, Addlestone, Surrey KT15 3NB.
Cooles
Sue W
SW
Veterinary Laboratories Agency (Weybridge), New Haw, Addlestone, Surrey KT15 3NB.
Sayers
Antony R
AR
Veterinary Laboratories Agency (Weybridge), New Haw, Addlestone, Surrey KT15 3NB.
Woodward
Martin J
MJ
Veterinary Laboratories Agency (Weybridge), New Haw, Addlestone, Surrey KT15 3NB.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004396:Coloring Agents / Q000494:pharmacology*; D003510:Cyclohexanes / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D006801:Humans; D008826:Microbial Sensitivity Tests; D012475:Salmonella / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D018709:Statistics, Nonparametric
D000900:Anti-Bacterial Agents; D004396:Coloring Agents; D003510:Cyclohexanes; D004202:Disinfectants