Inhibitory effect of peptide vilon on the development of induced rat urinary bladder tumors in rats.
The effect of peptide vilon (Lys-Glu) on urinary bladder carcinogenesis in rats was studied. Urinary bladder tumors were induced with a selective carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. The tumors developed in 56% vilon-treated animals and in 75.5% controls. Vilon 2-fold decreased the incidence of preneoplastic and early neoplastic changes in urinary bladder mucosa and significantly inhibited carcinogenesis.
Pliss
G B
GB
N. N. Petrov Institute of Oncology, Health Ministry of the Russian Federation.
Mel'nikov
A S
AS
Malinin
V V
VV
Khavinson
V K
VK
D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity; D004151:Dipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
D000276:Adjuvants, Immunologic; D002273:Carcinogens; D004151:Dipeptides; D002085:Butylhydroxybutylnitrosamine; C415909:lysylglutamic acid