Enhancement in fecal excretion of dioxin isomer in mice by several dietary fibers.
The effect of increased nutrients (protein, lipid, vitamins and minerals) on dioxin-induced toxic manifestations such as immune suppression, hepatic hypertrophy, splenic atrophy and enzyme induction was investigated in mice after oral administration of 1,2,3,4,7,8-HxCDD (HxCDD) as one of a representative compound of dioxin isomers. Consequently, it appeared that increased minerals and vitamins in the diet prevented immune suppression by HxCDD. In addition, to clarify the additive effect of nutrients and the ability to hasten the excretion of dioxins by dietary fiber, the adsorbing of dioxins by 16 dietary fibers was investigated by in vitro experiment. Among 16 dietary fibers, locust bean gum, pectin, alginic acid, guar gum, chitin and cellulose were effective in binding dioxin isomers. These dietary fibers also enhanced the fecal excretion of HxCDD in mice.
Aozasa
O
O
Faculty of Pharmaceutical Science, Setsunan University, Hirakata, Osaka, Japan. aozasa@pharm.setsunan.ac.jp
Ohta
S
S
Nakao
T
T
Miyata
H
H
Nomura
T
T
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D004043:Dietary Fiber; D004147:Dioxins / Q000009:adverse effects / Q000493:pharmacokinetics*; D004790:Enzyme Induction; D005243:Feces / Q000737:chemistry; D005260:Female; D007165:Immunosuppression Therapy; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009752:Nutritional Status; D013154:Spleen / Q000187:drug effects / Q000473:pathology
D004043:Dietary Fiber; D004147:Dioxins