Synthesis of the L-enantiomer of 4'-C-ethynyl-2'-deoxycytidine.
The L-enantiomer of 4'-C-ethynyl-2'-deoxycytidine (2) was synthesized, but did not show any activity against HIV-1 up to 100 microM.
Kohgo
S
S
Division of Life Science, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Mitsuya
H
H
Ohrui
H
H
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D004396:Coloring Agents; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism; D013778:Tetrazolium Salts; D013844:Thiazoles
C448765:4'-C-ethynyl-2'-deoxycytidine; D019380:Anti-HIV Agents; D004396:Coloring Agents; D007202:Indicators and Reagents; D013778:Tetrazolium Salts; D013844:Thiazoles; D003841:Deoxycytidine; C022616:thiazolyl blue