Structural and functional features of eukaryotic mRNA untranslated regions.
The crucial role of the non-coding portion of genomes is now widely acknowledged. In particular, mRNA untranslated regions are involved in many post-transcriptional regulatory pathways that control mRNA localization, stability and translation efficiency. We review in this paper the major structural and compositional features of eukaryotic mRNA untranslated regions and provide some examples of bioinformatic analyses for their functional characterization.
Pesole
G
G
Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, via Celoria, 26, 20133, Milan, Italy. graziano.pesole@unimi.it
Mignone
F
F
Gissi
C
C
Grillo
G
G
Licciulli
F
F
Liuni
S
S
D020413:3' Untranslated Regions / Q000235:genetics*; D020121:5' Untranslated Regions / Q000235:genetics*; D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D017124:Conserved Sequence; D016208:Databases, Factual; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D007438:Introns; D012333:RNA, Messenger / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid; D012091:Repetitive Sequences, Nucleic Acid
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D012333:RNA, Messenger