Effect of germanium-132 on low-density lipoprotein oxidation and atherosclerosis in Kurosawa and Kusanagi hypercholesterolemic rabbits.
Germanium-132 (Ge-132) was given at 200 mg/kg of body weight to 8-week-old Kurosawa and Kusanagi hypercholesterolemic (KHC) rabbits. Thirty-six weeks later, the susceptibility of plasma low-density lipoprotein to oxidation and the morphology of atherosclerosis in the aorta and coronary artery were investigated. Treatment with Ge-132 resulted in decreases in the oxidation rate and in the formation rate of thiobarbituric acid-reactive substances following copper-induced oxidation of LDL. Ge-132 is suggested to possess antioxidative properties, but this did not lead to any attenuation of atherosclerotic progression in the KHC rabbits.
Wakabayashi
Y
Y
Department of Medicine, University of Kitasato Medical School, Sagamihara, Japan. yasiwaka@med.kitasato-u.ac.jp
D000375:Aging / Q000473:pathology; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood*; D005260:Female; D005857:Germanium; D006937:Hypercholesterolemia / Q000097:blood* / Q000473:pathology; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000097:blood*; D009942:Organometallic Compounds / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011422:Propionates; D011817:Rabbits; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000924:Anticholesteremic Agents; D008077:Lipoproteins, LDL; D009942:Organometallic Compounds; D011422:Propionates; D017392:Thiobarbituric Acid Reactive Substances; D005857:Germanium; C066750:propagermanium