Identity of activation molecule 3 on superantigen-stimulated bovine cells is CD26.
Most CD8(+) T cells in cultures of bovine mononuclear cells stimulated with staphylococcal enterotoxin C1 develop an unusual phenotype characterized by expression of activation molecule 3 (ACT3). This superantigen-dependent phenotype may be relevant to immunopathogenesis mediated by certain microbial toxins. The size and N-terminal sequence of immunoprecipitated ACT3 indicate that ACT3 is the bovine orthologue of CD26.
Lee
S U
SU
Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 83844, USA.
Ferens
W
W
Davis
W C
WC
Hamilton
M J
MJ
Park
Y H
YH
Fox
L K
LK
Naessens
J
J
Bohach
G A
GA
D000595:Amino Acid Sequence; D000818:Animals; D015415:Biomarkers; D017252:CD3 Complex / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D002417:Cattle; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D018819:Dipeptidyl Peptidase 4 / Q000096:biosynthesis / Q000145:classification* / Q000276:immunology; D004768:Enterotoxins / Q000276:immunology* / Q000494:pharmacology; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology / Q000494:pharmacology; D008969:Molecular Sequence Data; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000276:immunology* / Q000494:pharmacology
D015415:Biomarkers; D017252:CD3 Complex; D004768:Enterotoxins; D007376:Interleukin-2; D018089:Superantigens; D003208:Concanavalin A; C034959:enterotoxin C, staphylococcal; D018819:Dipeptidyl Peptidase 4