Graft function and other risk factors as predictors of cardiovascular disease outcome.
The high incidence of cardiovascular disease after renal transplantation is related to a high prevalence and accumulation of risk factors before and after transplantation. Hypertension, posttransplantation diabetes, and hyperlipidemia are well-recognized risk factors for the development of cardiovascular events after renal transplantation and are strongly associated with immunosuppressive therapy. Hyperhomocysteinemia is a potential risk factor for cardiovascular disease in renal transplant recipients, but although a growing matter of study, a direct association with immunosuppressive agents is not yet proven. In addition to treatment intervention, risk management should also involve tailoring the immunosuppressive regimen to minimize the more indirect cardiovascular risk factors such as renal dysfunction and acute rejection.
Forsythe
J L
JL
Transplant Unit, The Royal Infirmary of Edinburgh, UK. john.forsythe@luht.scot.nhs.uk
D002318:Cardiovascular Diseases / Q000150:complications / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000209:etiology / Q000517:prevention & control; D006084:Graft Rejection / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D020138:Hyperhomocysteinemia / Q000209:etiology / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000517:prevention & control*; D012308:Risk Management
D007166:Immunosuppressive Agents