Avoidance of multiple pregnancies after ovulation induction by supernumerary preovulatory follicular reduction.
OBJECTIVE
To evaluate the effect of supernumerary preovulatory follicular reduction as an approach to avoid multiple pregnancies in ovulation induction or superovulation cycles.


METHODS
Retrospective study.


METHODS
Tertiary referral center.


METHODS
In 26 cycles, 24 patients underwent ovulation induction or superovulation with either clomiphene citrate or hMG.


METHODS
Selective follicle aspiration was performed before hCG administration.


METHODS
Clinical pregnancy rate and numbers of multiple pregnancies.


RESULTS
A mean number of 4.5 follicles with a diameter > or =15 mm and a mean number of 4.5 follicles with a diameter < or =14 mm were observed before hCG administration. A mean number of 2.3 follicles with a diameter > or =15 mm and a mean number of 1.8 follicles with a diameter < or =14 mm were aspirated before the hCG administration. Seven singleton pregnancies (26.9% per cycle) ensued from the treatment.


CONCLUSIONS
Aspiration of supernumerary follicles after ovulation induction or superovulation seems to be a valid approach to avoid multiple pregnancies without affecting pregnancy rate.
Albano
C
C
Centre for Reproductive Medicine, Dutch-speaking Brussels Free University, Brussels, Belgium. lriaaoc@az.vub.ac.be
Platteau
P
P
Nogueira
D
D
Cortvrindt
R
R
Smitz
J
J
Devroey
P
P
D000328:Adult; D005260:Female; D005498:Follicular Phase; D006801:Humans; D006080:Ovarian Follicle / Q000601:surgery*; D010062:Ovulation Induction / Q000009:adverse effects*; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple; D012189:Retrospective Studies; D013396:Suction