Acute pericarditis associated with 5-aminosalicylic acid (5-ASA) treatment for severe active ulcerative colitis.
A 17-year-old male who had been diagnosed with ulcerative colitis was prescribed 80 mg prednisolone and 1,500 mg 5-aminosalicylic acid (5-ASA) per day. Two weeks after initiating therapy, he was referred to our hospital for evaluation of chest pain and high fever. Electrocardiography (ECG) showed ST elevation in limb and precordial leads. Chest pain with high fever and ECG changes were resolved after 5-ASA was discontinued. Three weeks later, the administration of a low dose of 5-ASA was associated with the immediate recurrence of pericarditis associated with chest pain, suggesting a hypersensitive reaction to 5-ASA in this patient.
Ishikawa
N
N
First Department of Internal Medicine, Miyazaki Medical College, Kiyotake.
Imamura
T
T
Nakajima
K
K
Yamaga
J
J
Yuchi
H
H
Ootsuka
M
M
Inatsu
H
H
Aoki
T
T
Eto
T
T
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004452:Echocardiography; D004562:Electrocardiography; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000009:adverse effects* / Q000627:therapeutic use; D010493:Pericarditis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D012720:Severity of Illness Index
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine; D011239:Prednisolone