title: [Prevention and treatment of type 1 diabetes].
abstract: LANGERHANS ISLET TRANSPLANTATION: Early results have been promising with insulin production in all cases two years after transplantation. These encouraging results have been obtained with a specifically designed protocol for islet harvesting, immunosuppression and transplantation of a large quantity of islets from several donors. EARLY IMMUNOSUPPRESSION: Since diabetes mellitus type 1 is an autoimmune disease, immunosuppression could be a most interesting etiopathological solution. Results obtained both in mouse models and in humans given monoclonal humanized anti-lymphocyte T antibodies (hOKT3 gamma 1) during the first 6 weeks following diagnosis have been quite encouraging. TWO APPROACHES TO GENE THERAPY: For the first, the goal is to improve the transplantation technique by isolating the islets in vitro in an attempt to improve their function via ex vivo transfection of different genes. The second approach aims at treatment of the complications of diabetes, particularly lower limb arteritis and coronary artery disease. Here the vector is an adenovirus carrying a gene coding for VEGF, a growth factor with proangiogenic action.
authors.affiliation: CHU d'Amiens.
authors.forename: G
authors.initials: G
authors.lastname: Choukroun
mesh_terms: D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000628:therapy*; D015316:Genetic Therapy; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D016381:Islets of Langerhans Transplantation; D015337:Multicenter Studies as Topic