Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century.
Diphtheria toxin is one of the most extensively studied and well understood bacterial toxins. Ever since its discovery in the late 1800's this toxin has occupied a central focus in the field of toxinology. In this review, I present a chronology of major discoveries that led to our current understanding of the structure and activity of diphtheria toxin.
Collier
R J
RJ
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. jcollier@hms.harvard.edu
D036002:ADP Ribose Transferases; D001427:Bacterial Toxins; D004165:Diphtheria / Q000266:history*; D004167:Diphtheria Toxin / Q000737:chemistry / Q000266:history*; D005098:Exotoxins / Q000737:chemistry; D049672:History, 19th Century; D049673:History, 20th Century; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
D036002:ADP Ribose Transferases; D001427:Bacterial Toxins; D004167:Diphtheria Toxin; D005098:Exotoxins; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A