Pamidronate-induced remission of pain associated with hypertrophic pulmonary osteoarthropathy in chemoendocrine therapy-refractory inoperable metastatic breast carcinoma.
We describe an extremely rare case of a woman with pulmonary metastatic disease from breast cancer, who presented with features of hypertrophic pulmonary osteoarthropathy (HPOA). Pain associated with HPOA may be extremely disabling and resistant to treatment. Treatment with pamidronate, an inhibitor of osteoclastic bone resorption, given every 2 weeks by i.v. drip infusion, led to rapid disappearance of uncontrolled pain caused by HPOA.
Suzuma
T
T
Department of Surgery, Affiliated Kihoku Hospital, Wakayama Medical University, 219 Myouji, Katsuragicho, Itogun, Wakayama 649-7113, Japan. suzuma@mail.wakayama-med.ac.jp
Sakurai
T
T
Yoshimura
G
G
Umemura
T
T
Tamaki
T
T
Yoshimasu
T
T
Naito
Y
Y
D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000556:secondary*; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D010166:Palliative Care; D000077268:Pamidronate
D004164:Diphosphonates; D000077268:Pamidronate