title: The biologic basis of fatigue.
abstract: In spite of many remarkable advances in our understanding of the mechanisms of cancer biology, very little attention has been directed toward mechanisms underlying cancer-induced symptoms. Although fatigue is a widely prevalent complication of cancer, there is a paucity of both basic and clinical research in this area. This article details our current knowledge of mechanisms causing cancer-related fatigue and briefly discusses currently available therapeutic options. A framework for addressing gaps in our knowledge and recommendations for future research directions are proposed.
authors.affiliation: Division of Anesthesiology, Critical and Palliative Care, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4095, USA. hgutstein@mdanderson.org
authors.forename: H B
authors.initials: HB
authors.lastname: Gutstein
mesh_terms: D005221:Fatigue / Q000209:etiology*; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000503:physiopathology