Apolipoprotein E genotype, coagulation, and survival following acute stroke.
The authors hypothesized that divergent influences of the APOE epsilon4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, epsilon4 carriers had higher partial thromboplastin time ratios (p < 0.01) than non-epsilon4 carriers. Among 529 ischemic stroke patients, increasing epsilon4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in epsilon4-carrying ischemic stroke patients.
Weir
C J
CJ
Acute Stroke Unit, Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Scotland, UK. C.J.Weir@clinmed.gla.ac.uk
McCarron
M O
MO
Muir
K W
KW
Dyker
A G
AG
Bone
I
I
Lees
K R
KR
Nicoll
J A
JA
D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002543:Cerebral Hemorrhage / Q000097:blood / Q000235:genetics* / Q000401:mortality; D002544:Cerebral Infarction / Q000097:blood / Q000235:genetics* / Q000401:mortality; D005500:Follow-Up Studies; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D019934:International Normalized Ratio; D010314:Partial Thromboplastin Time; D015996:Survival Rate
D053327:Apolipoprotein E4; D001057:Apolipoproteins E