[Effects of NGF and CNTF on NO level in brain of burn rats].
OBJECTIVE
To investigate the injurious effects of NO to the brain and protective effect of NGF and CNTF following burn injury in rats.


METHODS
Following intubation of the lateral cerebroventricle, the rats were divided into four groups:sham burn, burn, burn + NGF, burn + CNTF. The contents of NO in various parts of brain in rats with 30% TBSA third degree scald were measured.


RESULTS
The contents of NO were increased in burned rats. NGF and CNTF could lower the contents of NO.


CONCLUSIONS
The brain injury caused by burns may be associated with increase of NO. The protective effect of NGF and CNTF on the brain of burn rats may be related to lowering of NO.
Chen
X
X
Department of Neurobiology, the Second Military Medical University, Shanghai, 200433.
He
C
C
Zhao
X
X
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002056:Burns / Q000378:metabolism*; D020934:Ciliary Neurotrophic Factor / Q000494:pharmacology*; D008297:Male; D020932:Nerve Growth Factor / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D020934:Ciliary Neurotrophic Factor; D009414:Nerve Growth Factors; D009569:Nitric Oxide; D020932:Nerve Growth Factor