title: Enhanced efficacy of anti-D immunoglobulin for treating ITP is not explained by higher immunoglobulin polymer content.
abstract: Several reports have suggested that low dose anti-D immunoglobulin is superior to high dose immunoglobulin for treatment of idiopathic thrombocytopenia purpura (ITP). However, some findings suggest that it is not the anti-D activity per se that is responsible for efficacy for treatment of ITP with anti-D immunoglobulin. Amongst alternative explanations for the mechanism of action is a relatively higher immunoglobulin polymer content of anti-D compared to other immunoglobulin products, which is more efficient in causing reticuloendothelial Fc receptor blockade. In order to investigate this we have evaluated the polymeric IgG content of anti-D and other immunoglobulin products. Different products showed considerable variation in immunoglobulin polymer content. There was no clear correlation between aggregate or dimer content and product type and anti-D as a class of product did not contain higher amounts of either dimer or aggregate compared to other products. Some manufacturers' products increased in polymer content on storage, but others did not show this effect. Therefore, higher immunoglobulin dimer and/or aggregate content cannot explain the increased efficacy of anti-D immunoglobulin for treatment of ITP. The role of polymeric Ig in efficacy for treatment of ITP is unclear.
authors.affiliation: Division of Immunobiology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Herts, EN6 3QG, UK.
authors.forename: C
authors.initials: C
authors.lastname: Dolman
authors.forename: S J
authors.initials: SJ
authors.lastname: Thorpe
authors.forename: R
authors.initials: R
authors.lastname: Thorpe
mesh_terms: D001704:Biopolymers / Q000737:chemistry; D019281:Dimerization; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000737:chemistry / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology / Q000628:therapy*; D011961:Receptors, Fc / Q000037:antagonists & inhibitors; D018029:Rho(D) Immune Globulin / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D001704:Biopolymers; D016756:Immunoglobulins, Intravenous; D011961:Receptors, Fc; D018029:Rho(D) Immune Globulin