Transmission of Mycobacterium tuberculosis among high school students in Korea.
METHODS
Screening of pulmonary tuberculosis (PTB) patients from high school students by chest radiography and sputum examination.


OBJECTIVE
To investigate transmission of Mycobacterium tuberculosis among high school students.


METHODS
The restriction fragment length polymorphism (RFLP) profiles of M. tuberculosis isolated from PTB patients of high school students were analysed.


RESULTS
Clustering cases were found in PTB patients screened among high school students. During this study, a single strain with a particular RFLP profile was found most frequently. This particular strain was also the one that was found to be most prevalent among Korean clinical isolates of M. tuberculosis during a nationwide TB prevalence survey previously done in 1995. This strain seems to be the most widely distributed one in Korea, and has thus been designated K1. In addition, by close examination of the RFLP profiles, it was also found that there existed 34 isolates that had RFLP profiles that were similar to the K1 strain. Therefore, K1 and K1-related strains (18.4% of strains, designated as the K family) seem to comprise the most dominant M. tuberculosis strains present in Korea.


CONCLUSIONS
Clustering cases were found in PTB patients screened among high school students in Korea. The K family was found to be most prevalent among the clinical isolates of M. tuberculosis found.
Kim
S J
SJ
Korean Institute of Tuberculosis, Korean National Tuberculosis Association, Seoul. sangjkim@soback.kornet21.net
Bai
G H
GH
Lee
H
H
Kim
H J
HJ
Lew
W J
WJ
Park
Y K
YK
Kim
Y
Y
D000293:Adolescent; D002648:Child; D016000:Cluster Analysis; D016172:DNA Fingerprinting; D015342:DNA Probes; D018562:Disease Transmission, Infectious; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D013183:Sputum / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission*
D015342:DNA Probes