Studies on 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase using chorismate mutase inhibitors.
The proposed cyclic mechanism of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase and the mechanism of chorismate mutase share certain structural and electronic similarities. In this report, we examine several inhibitors of chorismate mutase for their efficacy against KDO 8-P synthase.
Birck
M R
MR
Department of Medicinal Chemistry, 428 Church St., University of Michigan, Ann Arbor, 48109-1065, USA.
Husain
A
A
Sheflyan
G Y
GY
Ganem
B
B
Woodard
R W
RW
D001412:Bacillus subtilis / Q000201:enzymology; D002826:Chorismate Mutase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation
D004791:Enzyme Inhibitors; D010744:Phosphoric Monoester Hydrolases; C024329:3-deoxy-manno-octulosonate-8-phosphatase; D002826:Chorismate Mutase