title: Synthesis and characterisation of a new amphotericin B-methoxypoly(ethylene glycol) conjugate.
abstract: The reaction of methoxypoly(ethylene glycol)-4-nitrophenyl carbonate with amphotericin B has been used to prepare a new conjugate of amphotericin B (mPEG-AmB). A preliminary screening of in vitro antifungal activity has suggested that mPEG-AmB possesses a similar effect and a similar spectrum of activity as the conventional amphotericin B formulated with sodium desoxycholate.
authors.affiliation: Department of Organic Chemistry, University of Pardubice, Cs. legií 565, 532 10 Pardubice, Czech Republic. sedlak@upce.cz
authors.forename: M
authors.initials: M
authors.lastname: Sedlák
authors.forename: V
authors.initials: V
authors.lastname: Buchta
authors.forename: L
authors.initials: L
authors.lastname: Kubicová
authors.forename: P
authors.initials: P
authors.lastname: Simůnek
authors.forename: M
authors.initials: M
authors.lastname: Holcapek
authors.forename: P
authors.initials: P
authors.lastname: Kasparová
mesh_terms: D000666:Amphotericin B / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000935:Antifungal Agents; D011092:Polyethylene Glycols; D000666:Amphotericin B; C028210:monomethoxypolyethylene glycol