Stromal-cell-derived factor 1 prevents the emergence of the syncytium-inducing phenotype of HIV-1 in vivo.
In a correlative study, the mean plasma level of the chemokine stromal-cell-derived factor 1 (SDF-1) was lower in subjects with syncytium-inducing (SI) than in subjects with non-syncytium-inducing (NSI) HIV isolates, regardless of the CD4 cell count or when compared with HIV-negative individuals. Individuals with high SDF-1 had an 81% probability of having an NSI virus phenotype compared with individuals with lower SDF-1. Increased expression of SDF-1 may help explain why the more pathogenic SI HIV-1 variants do not appear in some individuals.
Llano
A
A
Retrovirology Laboratory irsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Spain.
Barretina
J
J
Blanco
J
J
Gutiérrez
A
A
Clotet
B
B
Esté
J A
JA
D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000097:blood* / Q000502:physiology; D015726:Giant Cells; D015658:HIV Infections / Q000097:blood / Q000473:pathology / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000502:physiology*; D006801:Humans; D010641:Phenotype
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC