[Minocycline for the treatment of bronchiolitis obliterans associated with rheumatoid arthritis].
We discribe a rare case of rheumatoid arthritis (RA) complicated with bronchiolitis obliterans that was successfully treated with minocycline. Sixty four-year old woman with a four-years history of RA was admitted to the hospital because of dyspnea on exertion and polyarthritis. Pulmonary function test revealed marked decrease in V25 (0.10 l/s: 6.9%) and MMFR (12.6%). High resolution CT of the lung showed scattered centri-lobular micronodules in both lung fields, mucoid impaction, and hyperinflation. These findings indicated the presence of bronchiolitis obliterans. After 3 months of the treatment with minocycline, the patient showed a significant improvement of both arthritis and pulmonary function. Chest CT findings also improved after 1 year. The present case suggests that minocycline is effective for the treatment of bronchiolitis obliterans seen in patients with RA.
Kase
C
C
Department of Internal Medicine & Radiology, Saint Marianna University School of Medicine, Kawasaki-city, Kanagawa.
Okubo
M
M
Yamasaki
M
M
Yamada
H
H
Suzuki
Y
Y
Hama
N
N
Ichikawa
Y
Y
Sasaka
K
K
Nakajima
Y
Y
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications*; D001989:Bronchiolitis Obliterans / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D008911:Minocycline