title: Retinal nerve fiber layer thickness remains unchanged following laser-assisted in situ keratomileusis.
abstract: OBJECTIVE
  To evaluate the effect of laser-assisted in situ keratomileusis (LASIK) on retinal nerve fiber layer (RNFL) thickness measurements obtained with scanning laser polarimetry (SLP), optical coherence tomography (OCT), and scanning laser tomography (SLT).
  
  
  METHODS
  Interventional case series.
  
  
  METHODS
  Twenty eyes (20 patients) undergoing LASIK were enrolled in this prospective study. SLP, OCT, and SLT examinations were performed 1 week prior to and 1 week and 4 weeks after LASIK surgery. Intraocular pressure was normal at all preoperative and postoperative examinations. SLP, OCT, and SLT mean RNFL thickness values, and SLT RNFL cross sectional area, rim area, and rim volume before and after LASIK were compared by the Student paired t test.
  
  
  RESULTS
  Mean patient age was 39.3 +/- 9.5 (SD) years (range, 28 to 62 years). Mean preoperative spherical equivalent refractive error was -3.9 +/- 1.9 diopters (D) (range, -1.4 to -8.00 D) and mean spherical equivalent refractive surgical correction was 3.6 +/- 1.9 D (range, 1.00 to 8.50 D). Mean RNFL thicknesses obtained by SLP were thinner 1 week and 4 weeks after LASIK (P < 0.01, for all comparisons, paired t test), whereas mean OCT RNFL thickness and SLT RNFL thickness, RNFL cross-section area, rim area, and rim volume measurements were unchanged 1 week and 4 weeks after LASIK (P > or = 0.05, for all comparisons, paired t test).
  
  
  CONCLUSIONS
  LASIK does not affect RNFL thickness. Alterations in SLP RNFL thickness measurements are due to alterations in corneal architecture rather than an actual LASIK-induced RNFL injury.
authors.affiliation: Department of Ophthalmology, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA.
authors.forename: R
authors.initials: R
authors.lastname: Gürses-Ozden
authors.forename: J M
authors.initials: JM
authors.lastname: Liebmann
authors.forename: D
authors.initials: D
authors.lastname: Schuffner
authors.forename: D F
authors.initials: DF
authors.lastname: Buxton
authors.forename: B D
authors.initials: BD
authors.lastname: Soloway
authors.forename: R
authors.initials: R
authors.lastname: Ritch
mesh_terms: D000328:Adult; D003315:Cornea / Q000601:surgery; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D007368:Interferometry; D020731:Keratomileusis, Laser In Situ; D007834:Lasers; D008027:Light; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery; D009412:Nerve Fibers; D009900:Optic Nerve / Q000033:anatomy & histology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000166:cytology*; D014054:Tomography / Q000379:methods; D058609:Visual Field Tests