[Influence of processing methods on alkaloid, toxicity and effect of Strychnos nux-vomica L].
Determination has been made on the contents of strychnine, brucine and ephedrin in different processed products of Strychnos nux-vomica. The acute toxicity, analgesic and antiphlogistic actions of these products have also been detected. The result shows that the product processed with Ephedra sinica can reduce toxicity and promote curative effect. Among the different processing methods the preparation with Ephedra and Liqorice root and the preparation with Ephedra and alcohol appear better and thus useful in practical application.
Chen
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Fujian Institute of Traditional Chinese Medicine and Pharmacology, Fuzhou 350003.
Gui
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Xie
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Z
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D004809:Ephedrine / Q000032:analysis; D005260:Female; D006358:Hot Temperature; D007928:Lethal Dose 50; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D013331:Strychnine / Q000031:analogs & derivatives* / Q000032:analysis*; D013678:Technology, Pharmaceutical / Q000379:methods
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C083806:brucine; D004809:Ephedrine; D013331:Strychnine