title: Molecular pathogenesis of the von Hippel-Lindau hereditary cancer syndrome: implications for oxygen sensing.
authors.affiliation: Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: W G
authors.initials: WG
authors.lastname: Kaelin
mesh_terms: D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism; D044842:Cullin Proteins; D004195:Disease Models, Animal; D000075065:Elongin; D005109:Extracellular Matrix / Q000378:metabolism; D005838:Genotype; D006801:Humans; D000860:Hypoxia; D008025:Ligases / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000503:physiopathology; D010100:Oxygen / Q000378:metabolism*; D010641:Phenotype; D011499:Protein Processing, Post-Translational; D014157:Transcription Factors / Q000378:metabolism; D025521:Tumor Suppressor Proteins; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D006623:von Hippel-Lindau Disease / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology
chemical_list: C105153:CUL2 protein, human; D018797:Cell Cycle Proteins; D044842:Cullin Proteins; D000075065:Elongin; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D014452:Ubiquitins; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D008025:Ligases; C497446:VHL protein, human; D010100:Oxygen