title: The relationship between new stroke onset and serum thiocyanate as an indicator to cigarette smoking.
abstract: The case subjects were 67 stroke patients (27 males and 40 females, mean age 65.7+/-7.1), who suffered from stroke attack and had participated in annual medical check-up between 1987 and 1988 at Oyabe Public Health Center. The controls, which were adjusted for sex, age and blood pressure level with the case subjects, were selected from participants attending their annual medical check-up in 1987-1988. The serum thiocyanate level of case subjects were significantly higher than that of controls (p<0.05). The usefulness of measurement of serum thiocyanate level as an indicator of smoking status was assessed by using multiple logistic regression analysis adjusting for body mass index, mean blood pressure, and serum cholesterol was found. An odds ratio of 3.00 (95% confidence interval: 1.06-8.48, p<0.05) in cerebral infarction. It is considered that serum thiocyanate may be useful as an indicator of smoking status to assess the relationship with stroke onset, especially for cerebral infarction.
authors.affiliation: Department of Welfare Promotion and Epidemiology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Sekine
authors.forename: H
authors.initials: H
authors.lastname: Yokokawa
authors.forename: S
authors.initials: S
authors.lastname: Hamanishi
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Sayama
authors.forename: Y
authors.initials: Y
authors.lastname: Naruse
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: S
authors.initials: S
authors.lastname: Kagamimori
mesh_terms: D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D015897:Comorbidity; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D018570:Risk Assessment / Q000379:methods; D017678:Sex Distribution; D012907:Smoking / Q000097:blood* / Q000453:epidemiology*; D020521:Stroke / Q000097:blood* / Q000453:epidemiology* / Q000517:prevention & control; D013861:Thiocyanates / Q000097:blood*
chemical_list: D015415:Biomarkers; D013861:Thiocyanates; D002784:Cholesterol; C031760:thiocyanate