title: Optical resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline by supercritical fluid extraction.
abstract: 6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) enantiomers were separated by supercritical fluid extraction using carbon dioxide. Diastereoisomeric salts were formed from the racemic base with less than one equivalent of O,O'-di-(4-toluoyl)-(2R,3R)-tartaric acid (DPTTA). Further purification was achieved by partial salt formation of the enantiomeric mixture with an achiral acid (HCl) followed by the supercritical fluid extraction of the free enantiomers.
authors.affiliation: Budapest University of Technology and Economics, Department of Chemical Engineering, Budapest, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Kmecz
authors.forename: B
authors.initials: B
authors.lastname: Simándi
authors.forename: J
authors.initials: J
authors.lastname: Bálint
authors.forename: E
authors.initials: E
authors.lastname: Székely
authors.forename: E
authors.initials: E
authors.lastname: Fogassy
authors.forename: S
authors.initials: S
authors.lastname: Kemény
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification*; D002245:Carbon Dioxide / Q000737:chemistry; D007202:Indicators and Reagents; D011804:Quinolines / Q000302:isolation & purification*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: C440210:6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline; D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D011804:Quinolines; D002245:Carbon Dioxide