[Determination of scalp ER and AR of patients with male pattern baldness and the effects of hair transplantation on them].
OBJECTIVE
To study the role of sex hormone receptor capacity of the scalp in male pattern baldness(MPB).


METHODS
Estrogen receptor(ER) and androgen receptor(AR) assays were performed using fluorescent steroid hormone conjugate technique (FSHCT) in hairness and bald scalp in 8 patients with MPB. Changes of ER and AR capacity in recipient and donor sites of hair transplantation in MPB scalps were examined.


RESULTS
The percentage of AR staining cells in the outer root sheath, sebaceous gland and bulb papilla of the lesional scalps was significantly higher than that of hairness scalps (P < 0.01). The percentage of ER positive cells in the outer root sheath of lesional scalps increased significantly (P < 0.01).


CONCLUSIONS
Changes of contents of sex hormone receptors(SHR) in some sensitive area of the scalp induce MPB.
Chen
X
X
Department of Plastic Surgery, First Affiliated Hospital of Hubei Medical University, Wuhan 430060, PR China.
Long
D
D
Wang
S
S
D000328:Adult; D000505:Alopecia / Q000378:metabolism / Q000601:surgery*; D006197:Hair / Q000637:transplantation*; D006801:Humans; D008297:Male; D011944:Receptors, Androgen / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D012535:Scalp / Q000378:metabolism*
D011944:Receptors, Androgen; D011960:Receptors, Estrogen