Effects of strain, behavior and age on the self-administration of ethanol, nicotine, cocaine and morphine by two rat strains.
Two genetically different strains, Brown Norway rats (BNR) and Wistar Kyoto rats (WKR), with the latter showing higher emotionality and lower plasma stress catecholamine responses, were compared for their voluntary intake of ethanol, nicotine, cocaine and morphine. Younger BNR self-administered the same amounts of all 4 substances as did the younger WKR suggesting a similar genetic basis for all drugs at this age. Older BNR consumed less ethanol and nicotine but equal amounts of cocaine and morphine as compared to older WKR, and older BNR were more sensitive to the effects of ethanol than WKR suggesting a different genetic basis for different drugs at an older age. Forcing both strains to consume one of the drugs did not affect a subsequent voluntary consumption of ethanol and morphine but reduced nicotine intake in WKR and decreased cocaine intake in both strains suggesting that drug use is determined by individual preferences and not drug exposure per se. The behavioral characteristics of both strains coincide only with the self-administration of ethanol and nicotine supporting a possible genetic linkage between anxiety/stress and ethanol and nicotine use.
Todte
K
K
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pa. 19107, USA.
Tselis
N
N
Dadmarz
M
M
Golden
G
G
Ferraro
T
T
Berrettini
W H
WH
Vogel
W H
WH
D000284:Administration, Oral; D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003042:Cocaine / Q000008:administration & dosage* / Q000494:pharmacology*; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000008:administration & dosage* / Q000494:pharmacology*; D009538:Nicotine / Q000008:administration & dosage* / Q000494:pharmacology*; D051381:Rats; D011914:Rats, Inbred BN; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D012646:Self Administration
D000431:Ethanol; D009538:Nicotine; D009020:Morphine; D003042:Cocaine