title: Influence of adjuvants on the dissolution profile of tablets containing high doses of spray-dried extract of Maytenus ilicifolia.
abstract: A 2(3) factorial design was used in order to evaluate the influence of some adjuvants on the dissolution profile of tablets containing high doses of Maytenus ilicifolia spray-dried extract. Tablets were prepared on a single punch tablet press using 15 mm flat punches by individual direct compression of 650 mg from each formulation containing 375 mg of the spray-dried extract. The factors investigated were disintegrant (croscarmellose sodium or sodium starch glycolate), lubricant (colloidal silicon dioxide or magnesium stearate) and filler/binder (microcrystalline cellulose or lactose). The dissolution profiles were analyzed to determine the dissolution kinetics, the dissolution half-lives (t50%), the similarity factor (f2) and the dissolution efficiency (DE %), which was selected as the response criteria to evaluate the factorial design. The results revealed that in spite of the high content of spray-dried powder in the tablets, the dissolution profiles of the extract did depend on the adjuvant used. The filler/binder had the most important effect on the dissolution efficiency of the tablets.
authors.affiliation: Programa de Pòs-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre-RS, Brazil.
authors.forename: T P
authors.initials: TP
authors.lastname: de Souza
authors.forename: V L
authors.initials: VL
authors.lastname: Bassani
authors.forename: G
authors.initials: G
authors.lastname: González Ortega
authors.forename: T C
authors.initials: TC
authors.lastname: dalla Costa
authors.forename: P R
authors.initials: PR
authors.lastname: Petrovick
mesh_terms: D000277:Adjuvants, Pharmaceutic; D000465:Algorithms; D002482:Cellulose; D005079:Excipients; D006207:Half-Life; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012995:Solubility; D013607:Tablets
chemical_list: D000277:Adjuvants, Pharmaceutic; D005079:Excipients; D010936:Plant Extracts; D013607:Tablets; D002482:Cellulose