title: Long-term colchicine for recalcitrant palmoplantar pustulosis: treatment outcome in 3 patients.
abstract: Palmoplantar pustulosis (PPP) is a chronic, relapsing, pustular eruption affecting the palms and soles for which treatment is often difficult and frustrating. Short-term colchicine has been used to treat PPP with variable response. We report on the successful treatment of 3 patients with severe, therapy-resistant, chronic PPP. We observed significant reduction in the frequency of pustular eruptions and the number of pustules with maximum tolerable doses of colchicine treatment for up to 12 months.
authors.affiliation: National Skin Centre, Singapore. kysswong@yahoo.com
authors.forename: S S
authors.initials: SS
authors.lastname: Wong
authors.forename: K C
authors.initials: KC
authors.lastname: Tan
authors.forename: C L
authors.initials: CL
authors.lastname: Goh
mesh_terms: D000328:Adult; D003078:Colchicine / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects; D011565:Psoriasis / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D003879:Dermatologic Agents; D003078:Colchicine