title: Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors.
abstract: A new series of potent and selective cyclooxygenase-2 inhibitors have been prepared. Some of these compounds show good oral anti-inflammatory activity in rats.
authors.affiliation: Almirall Prodesfarma, Research Center, Cardener 68-74, 08024, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Feixas
authors.forename: J M
authors.initials: JM
authors.lastname: Jiménez
authors.forename: N
authors.initials: N
authors.lastname: Godessart
authors.forename: C
authors.initials: C
authors.lastname: Puig
authors.forename: L
authors.initials: L
authors.lastname: Soca
authors.forename: M I
authors.initials: MI
authors.lastname: Crespo
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D009281:Naphthalenes; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases