[Effect of Silybum marianum oil and legalon on lipid peroxidation and liver antioxidant systems in rats intoxicated with carbon tetrachloride].
An oil obtained from the seeds of Saint-Mary thistle (Silybum marianum) and the drug legalon (silybinin) prepared from this plant produce an antioxidant effect on liver tissues of rats poisoned with carbon tetrachloride. Legalon (25 mg/kg) and the oil (2000 mg) reduced the level of lipid peroxidation, increased the catalase activity, but did not reduce the concentration of selenium in liver (which decreased as a result of CCl4 intoxication). Legalon significantly increased the activity of superoxide dismutase in liver tissues, while the Saint-Mary thistle oil did not produce such effect.
Batakov
E A
EA
Pharmacology Department, General Surgery Department, Samara State Medical University, Chapaevskaya ul. 89, Samara, 443099 Russia.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D020944:Silybum marianum; D008517:Phytotherapy; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012838:Silymarin / Q000494:pharmacology* / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D010938:Plant Oils; D020011:Protective Agents; D012838:Silymarin; D002374:Catalase; D013482:Superoxide Dismutase