Food restriction affects the gonadotropin releasing hormone neuronal system of male prairie voles (Microtus ochrogaster).
Individuals of species inhabiting temperate and boreal latitudes optimize the timing of energetically costly processes by curtailing nonessential energetically demanding processes when environmental conditions are not favourable. One proximate environmental variable used to fine-tune moment-to-moment changes in reproductive physiology and behaviour is food intake. The neuroendocrine mechanisms by which food restriction leads to the cessation of reproduction in seasonally breeding rodent species remain largely unspecified. The present study sought to determine the effects of extended food restriction on the gonadotropin releasing hormone (GnRH) neuronal system. Male prairie voles (Microtus ochrogaster) were either fed ad libitum or were exposed to either 1, 2 or 3 weeks of moderate (70% of daily mean) food restriction. In accordance with previous studies of food restriction, gross reproductive organ masses and body mass were unaffected by food deprivation. Although 1 week of food restriction did not result in alterations in the GnRH neuronal system, food restriction for 2 weeks was associated with increased GnRH-immunoreactive (GnRH-ir) neurone soma size. Three weeks of food restriction resulted in a pronounced increase in GnRH-ir neurone numbers, as well as an increase in fibre intensity in the main fibre pathway to the median eminence. Taken together, these findings suggest that extended food restriction leads to modifications in the GnRH neuronal system, providing a means for temporary cessation of reproduction without gross alterations in reproductive physiology. This transient change in the hypothalmo-pituitary-gonadal axis, without pronounced changes in reproductive organ morphology, likely provides a mechanism for the rapid reinitiation of breeding in nature when local conditions provide adequate food availability.
Kriegsfeld
L J
LJ
Department of Psychology, The Johns Hopkins University, Baltimore, MD, USA.
Ranalli
N J
NJ
Trasy
A G
AG
Nelson
R J
RJ
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D003411:Arvicolinae / Q000502:physiology*; D001921:Brain / Q000166:cytology / Q000502:physiology; D002452:Cell Count; D048429:Cell Size; D005508:Food Deprivation / Q000502:physiology*; D005625:Frontal Lobe / Q000166:cytology / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D007032:Hypothalamus, Anterior / Q000166:cytology / Q000502:physiology; D008297:Male; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D011301:Preoptic Area / Q000166:cytology; D012688:Septum Pellucidum / Q000166:cytology / Q000502:physiology; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone