[Radiosensitization effect of taxol on malignant tumor cells].
Radiosensitizating abilities of taxol have been investigated in vitro using L929 cells and in vivo Geren carcinoma (T-8 cell line). Radiosensitizating effect of taxol was detected for the both cell lines. Pathologic mitoses have been also analyzed and increasing of abnormal mitosis total level was observed. It is supposed that this phenomenon could determine radiosensitizating abilities of taxol.
Baraboi
V A
VA
Zinchenko
V A
VA
Sorochins'kii
B V
BV
Blium
I O
IO
Kovalenko
N V
NV
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D007739:L Cells; D051379:Mice; D017239:Paclitaxel / Q000494:pharmacology*; D011839:Radiation, Ionizing; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D011838:Radiation-Sensitizing Agents; D017239:Paclitaxel