[A low-calories diet as a model of life span expansion and study of mechanisms of aging].
The model of experimental augmentation of life expectancy animal with the help of a low-calorie diet designed empirically more 50-[symbol: see text] of years back. The translation animal on such diet is accompanied by development of stress--response and the further adaptation to restricted power supply. As a result of it occurs complex change in all metabolic systems of an organism (energy system of a cell, endocrine, immune system, system of toxicity release, connecting tissue, activity genetic and system which synthesizes an protein). The orientation of these changes provides retardation of development, delay of formation age-dependent of pathologies, and as the consequence, augmentation average life and, that is especially important, maximal life expectancy. The effect of augmentation of life expectancy at use of low-calorie diets depends on quantitative restriction of a calorific within the framework of 40-75%, sex and genotype animal, age animal at the moment of translation on a diet. The proposition expresses, that the prolongation of life at use to a low-calorie diet can be surveyed as specific response of some organisms in a population (not everything, the part animal perishes in a start of experiment) on such stressful action as restriction of nutrition.
Bozhkov
A I
AI
Research Institute of Biology, Kharkov National University by V.N. Karazin, 61077, Kharkov, 4 Svobody sq., Ukraine. bozhkov@univer.kharkov.ua
D000367:Age Factors; D000375:Aging / Q000502:physiology; D000818:Animals; D002149:Energy Intake; D005247:Feeding Behavior; D006801:Humans; D008136:Longevity / Q000502:physiology*