[The genetics of labio-palatal clefts].
Labial and/or palatine clefts are an interest in example of the interaction between genetic and environmental factors. The OFC1 gene, localized on 6p24.3 would play a primary role in the development of labial and/or palatine clefts while the OFC2 (2p13), OFC3 (19p13.2) and RARA (17q21.1) would play a role in modifying genetic susceptibility. Different environmental, nutritional and toxic factors (alcohol, tobacco, drugs...) could also directly contribute one-third of these oral clefts. Identification of subjects at risk of having a child with labial and/or palatine cleft on the basis of both phenotypic and genotypic factors would be most helpful in recognizing environmental factors triggering their development, a first step towards prevention.
Rival
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JM
Service de Génétique Médicale, Hôtel-Dieu, CHU, 1 place Alexis Ricordeau, 44093 Nantes.
David
A
A
D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D002971:Cleft Lip / Q000209:etiology / Q000235:genetics*; D002972:Cleft Palate / Q000209:etiology / Q000235:genetics*; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009747:Nutritional Physiological Phenomena; D010641:Phenotype; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects