Wnts, signaling and sulfates.
Questions remain about the signaling pathways that control pattern formation during development. Blair describes how sulfated glycosaminoglycans affect several developmentally important signaling pathways, including Wnt-Wingless, Fibroblast growth factor, Hedgehog, and Bone morphogenetic protein-4 signaling. A new secreted sulfatase, Qsulf1, regulates the sensitivity of vertebrate cells to Wnts, possibly by modifying the sulfation of glycosaminoglycans.
Blair
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SS
Department of Zoology, University of Wisconsin, 250 N. Mills St., Madison, WI 53706, USA. ssblair@facstaff.wisc.edu
D000818:Animals; D019521:Body Patterning; D004330:Drosophila / Q000196:embryology / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D019476:Insect Proteins / Q000502:physiology*; D008956:Models, Chemical; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction; D013429:Sulfatases / Q000502:physiology*; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D006025:Glycosaminoglycans; D019476:Insect Proteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D013429:Sulfatases