A new isoquinoline alkaloid from the marine sponge Haliclona species.
Two isoquinoline alkaloids, including the new compound 1, were isolated from the cytotoxic fractions of an aqueous extract of the marine sponge Haliclona sp. The structures of these compounds were established as 1-hydroxymethyl-7-methoxyisoquinolin-6-ol (1) and mimosamycin (2) by conventional spectroscopic methods and by comparison with related compounds. Mimosamycin (2) was the principal cytotoxin with an IC(50) of approximately 10 microg/mL against melanoma and ovarian human tumor cell lines.
Rashid
M A
MA
Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA.
Gustafson
K R
KR
Boyd
M R
MR
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma; D015394:Molecular Structure; D010051:Ovarian Neoplasms; D010679:Philippines; D011161:Porifera / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured / Q000187:drug effects
C438632:1-hydroxymethyl-7-methoxyisoquinolin-6-ol; D000470:Alkaloids; D000970:Antineoplastic Agents; D007546:Isoquinolines; C018106:mimosamycin