title: [Chromosomal aberration analyzed by comparative genomic hybridization in nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To identify genetic alteration in primary sporadic nasopharyngeal carcinoma(NPC) in Hunan.
  
  
  METHODS
  Comparative genomic hybridization was applied to investigate the genomic imbalance in a series of 20 cases of primary nasopharyngeal carcinomas.
  
  
  RESULTS
  The common chromosomal alterations included gains of chromosomes 1q, 2, 3q, 7q,8q,12 as well as losses of chromosomes 3p, 9p, 11q, 16q.
  
  
  CONCLUSIONS
  There are multiple regions of chromosomes with copy number changes in NPC. The tumor suppressor genes and oncogenes on these regions may be involved in the development and progress of nasopharyngeal carcinoma.
authors.affiliation: Tumor Cellular Genetic Lab, Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, 410078 P.R. China. ligy@public.cs.hn.cn
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: Z
authors.initials: Z
authors.lastname: Zeng
authors.forename: M
authors.initials: M
authors.lastname: Zhou
authors.forename: W
authors.initials: W
authors.lastname: Huang
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Li
mesh_terms: D002869:Chromosome Aberrations; D016147:Genes, Tumor Suppressor; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D009693:Nucleic Acid Hybridization