title: Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity.
abstract: The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described. The chemical structures of the compounds were elucidated by IR, 1H-NMR and mass spectral studies. These compounds were tested for analgesic activity.
authors.affiliation: Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470, Eskişehir, Turkey. gzitouni@anadolu.edu.tr
authors.forename: G
authors.initials: G
authors.lastname: Turan-Zitouni
authors.forename: M
authors.initials: M
authors.lastname: Sivaci
authors.forename: F S
authors.initials: FS
authors.lastname: Kiliç
authors.forename: K
authors.initials: K
authors.lastname: Erol
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000627:therapeutic use*; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000627:therapeutic use*; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement / Q000379:methods; D014230:Triazoles / Q000138:chemical synthesis* / Q000627:therapeutic use*
chemical_list: C445527:4-((3-(4-chlorophenoxy-1-ethyl)-4-ethyl-1,2,4-triazol-5-yl)thioacetamido)antipyrine; D000700:Analgesics; D014230:Triazoles; D000983:Antipyrine