Recent advances on molecular mechanisms involved in amino acid control of gene expression.
In mammals, the impact of nutrients on gene expression has become an important area of research. Because amino acids have multiple and important functions, their homeostasis has to be finely maintained. However, amino acidaemia can be affected by certain nutritional conditions or various forms of aggression. It follows that mammals have to adjust several of their physiological functions involved in the adaptation to amino acid availability by regulating the expression of numerous genes. It has been shown that amino acids by themselves can modify the expression of target genes. However, the current understanding of amino acid-dependent control of gene expression has just started to emerge. This review focuses on the recent advances on mechanisms involved in the amino acids control of gene expression. Several examples discussed in this paper demonstrate that amino acids regulate gene expression at the level of transcription, messenger RNA stability and translation.
Bruhat
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A
Unité de Nutrition Cellulaire et Moléculaire, INRA de Theix, 63122 Saint Genès Champanelle, France.
Fafournoux
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P
D000596:Amino Acids / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001217:Aspartate-Ammonia Ligase / Q000378:metabolism; D001483:Base Sequence; D001682:Biological Availability; D023081:CCAAT-Binding Factor / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D009752:Nutritional Status; D014176:Protein Biosynthesis; D015398:Signal Transduction; D013217:Starvation; D014158:Transcription, Genetic
D000596:Amino Acids; D023081:CCAAT-Binding Factor; D001217:Aspartate-Ammonia Ligase