title: Self-reported nonadherence with antiretroviral drugs predicts persistent condition.
abstract: OBJECTIVE
  To assess variables predictive of nonadherence persisting over time in HIV-infected people treated with highly active antiretroviral therapy.
  
  
  METHODS
  Prospective study of consecutive HIV-infected patients who were prescribed ritonavir- or indinavir-containing regimens in a university-based HIV clinic in Rome. A patient questionnaire assessing knowledge of treatment regimen, adherence behavior, reasons for taking and missing therapy, factors influencing adherence, and health behaviors was administered at baseline and 1 year later. A predose protease inhibitor plasma level was measured concurrently. Persistent nonadherence was defined as patient self-reported nonadherence both at enrollment and at follow-up questionnaires.
  
  
  RESULTS
  From April 1998 to July 1998, 140 patients were enrolled into the study. At follow-up, 10% remained persistently nonadherent, and 15% of the previously adherent patients became nonadherent. On bivariate analysis, being less than 35 years old (odds ratio [OR] 8.9; 95% CI 1.8-43.1; p =.002), self-reporting nonadherence at enrollment (OR 14.5; 95% CI 3.5-5.8; p <.001), and having experienced "a fair amount" or "a lot" of vomiting (OR 11.1;95% CI 1.6-74.7; p =.02) or pruritus (OR 16.4; 95% CI 2.6-102.8; p =.004) during the 4 weeks before enrollment were significantly correlated to persistent nonadherence.
  
  
  CONCLUSIONS
  Previous self-reported nonadherence was a strong predictor of persistent nonadherence during follow-up. Moreover, being of younger age and self-reporting vomiting or pruritus were also associated with a higher risk of nonadherence persisting over time.
authors.affiliation: Department of Infectious Diseases, Catholic University of Rome, Italy. ritanto@iol.it
authors.forename: R
authors.initials: R
authors.lastname: Murri
authors.forename: A
authors.initials: A
authors.lastname: Ammassari
authors.forename: A
authors.initials: A
authors.lastname: De Luca
authors.forename: A
authors.initials: A
authors.lastname: Cingolani
authors.forename: P
authors.initials: P
authors.lastname: Marconi
authors.forename: A W
authors.initials: AW
authors.lastname: Wu
authors.forename: A
authors.initials: A
authors.lastname: Antinori
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000503:physiopathology; D015497:HIV-1; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011795:Surveys and Questionnaires; D016312:Treatment Refusal / Q000706:statistics & numerical data