title: Nesidioblastosis coexisting with islet cell tumor and intraductal papillary mucinous hyperplasia.
abstract: A coexisting of intraductal papillary mucinous hyperplasia (IPMH) and islet cell tumor with nesidioblastosis of the pancreas in a 51-year-old man is reported. All of the clinical data indicated an insulinoma. A distal pancreatectomy was performed. A discrete mass measuring 1.9 x 2.0 cm was grossly identified in the tail of the pancreas. There were no other gross lesions. An islet cell tumor with nesidioblastosis was confirmed by immunostains and ultrastructural study. In addition, an IPMH was found that involved mainly branches of the pancreatic duct. The islet cell tumor and IPMH were topographically separated; however, there was a histologically intimate relationship between the nesidioblastosis and the IPMH. These findings indicate that the IPMH may have derived from autocrine and paracrine influences on the existing duct epithelial cells. To the best of our knowledge, this is the first report of nesidioblastosis coexisting with islet cell tumor and IPMH.
authors.affiliation: Department of Pathology, Harbor/UCLA Medical Center, Torrance, CA 90509, USA. xzhao@prl.humc.edu
authors.forename: X
authors.initials: X
authors.lastname: Zhao
authors.forename: B E
authors.initials: BE
authors.lastname: Stabile
authors.forename: J
authors.initials: J
authors.lastname: Mo
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: S W
authors.initials: SW
authors.lastname: French
mesh_terms: D007516:Adenoma, Islet Cell / Q000150:complications* / Q000473:pathology / Q000601:surgery; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000473:pathology; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000150:complications* / Q000473:pathology / Q000601:surgery; D010183:Pancreatic Ducts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery
chemical_list: D019394:Ki-67 Antigen