title: Polymorphism of the human muc genes.
abstract: Mucins encoded by the MUC genes share the common feature of having an extensive tandem repeat region that encompasses a large proportion of the coding sequence. In many of the genes this tandem repeat region shows a great deal of allelic length variation and recently studies have demonstrated person to person variation in pattern of nucleotide or amino-acid changes in the repeat units. The length and sequence variability will be discussed in this review, as will its role in disease susceptibility.
authors.affiliation: Galton Laboratory, Department of Biology, Wolfson House, 4 Stephenson Way, London NW1 2HE.
authors.forename: J
authors.initials: J
authors.lastname: Fowler
authors.forename: L
authors.initials: L
authors.lastname: Vinall
authors.forename: D
authors.initials: D
authors.lastname: Swallow
mesh_terms: D006801:Humans; D018598:Minisatellite Repeats / Q000235:genetics; D009077:Mucins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D020033:Protein Isoforms / Q000235:genetics
chemical_list: D009077:Mucins; D020033:Protein Isoforms