title: Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species.
abstract: Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.
authors.affiliation: Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho, Okinawa 903-0213, Japan.
authors.forename: M J
authors.initials: MJ
authors.lastname: Uddin
authors.forename: S
authors.initials: S
authors.lastname: Kokubo
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: K
authors.initials: K
authors.lastname: Suenaga
authors.forename: D
authors.initials: D
authors.lastname: Uemura
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D005260:Female; D020128:Inhibitory Concentration 50; D007564:Japan; D007941:Leukemia P388; D007945:Leukemia, Lymphoid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010063:Ovum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D012617:Sea Urchins / Q000187:drug effects / Q000196:embryology / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D004224:Diterpenes