title: Physiological aspects of pig-to-primate renal xenotransplantation.
abstract: BACKGROUND
  Few data exist on the physiological aspects of pig-to-primate renal xenotransplantation.
  
  
  METHODS
  Use of organs transgenic for human decay accelerating factor has allowed assessment of the metabolic and hormonal functions of these xenografts.
  
  
  RESULTS
  Porcine renal xenografts largely maintain plasma electrolyte homeostasis. An increase in proteinuria was detected that may result from graft injury. In contrast to allotransplantation a severe anaemia developed requiring recipient treatment with exogenous human erythropoietin.
  
  
  CONCLUSIONS
  Our experience provides qualified encouragement for the likely physiological compatibility of pig and primate species, but identifies areas where a xenograft may not match the performance of an allograft.
authors.affiliation: Nuffield Department of Surgery, John Radcliffe Hospital, Oxford University, Oxford, England, United Kingdom.
authors.forename: B
authors.initials: B
authors.lastname: Soin
authors.forename: K G
authors.initials: KG
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Zaidi
authors.forename: E
authors.initials: E
authors.lastname: Cozzi
authors.forename: J R
authors.initials: JR
authors.lastname: Bradley
authors.forename: D J
authors.initials: DJ
authors.lastname: Ostlie
authors.forename: A
authors.initials: A
authors.lastname: Lockhart
authors.forename: D J
authors.initials: DJ
authors.lastname: White
authors.forename: P J
authors.initials: PJ
authors.lastname: Friend
mesh_terms: D000740:Anemia / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D004573:Electrolytes / Q000097:blood / Q000652:urine; D004921:Erythropoietin / Q000097:blood / Q000627:therapeutic use; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation / Q000009:adverse effects; D008252:Macaca fascicularis; D011507:Proteinuria / Q000209:etiology / Q000652:urine; D011994:Recombinant Proteins / Q000627:therapeutic use; D013552:Swine; D014183:Transplantation, Heterologous
chemical_list: D004573:Electrolytes; D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin