title: Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells.
abstract: Ca(2+) signal in high-Ca(2+) perimitochondrial microdomains is amplified within the mitochondrial matrix and activates Ca(2+)-dependent dehydrogenases. In steroid-secreting cells, small cytoplasmic Ca(2+) signals may also augment mitochondrial Ca(2+) concentration. The ensuing formation of NADH and NADPH may have an essential role in supporting the increased steroid secretion.
authors.affiliation: Department of Physiology, Faculty of Medicine, Semmelweis University, H-1444 Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Spät
authors.forename: J G
authors.initials: JG
authors.lastname: Pitter
authors.forename: T
authors.initials: T
authors.lastname: Rohács
authors.forename: G
authors.initials: G
authors.lastname: Szabadkai
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism*
chemical_list: D013256:Steroids