Is coasting effective for preventing ovarian hyperstimulation syndrome in patients receiving a gonadotropin-releasing hormone antagonist during an in vitro fertilization cycle?
OBJECTIVE
To report two cases of coasting during receipt of GnRH antagonists.


METHODS
Case report.


METHODS
University hospital.


METHODS
One 27-year-old and one 28-year-old woman, both with risk factors for the ovarian hyperstimulation syndrome (OHSS).


METHODS
Two IVF treatments during which hMG treatment was stopped until E2 decreased to a safer level during receipt of GnRH antagonist.


METHODS
Development of OHSS and pregnancy.


RESULTS
Embryos were transferred in both women. Neither woman developed OHSS and one ongoing pregnancy was obtained.


CONCLUSIONS
Coasting is feasible when a GnRH antagonist is used during IVF. Further studies are needed to evaluate its preventive role in OHSS.
Delvigne
A
A
IVF Center, Department of Obstetrics and Gynecology, St. Peter University Hospital, Rue Haute, 322, 1000, Brussels, Belgium. annick.delvigne@yucom.be
Carlier
C
C
Rozenberg
S
S
D000328:Adult; D004334:Drug Administration Schedule; D004958:Estradiol / Q000097:blood; D005240:Feasibility Studies; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage* / Q000627:therapeutic use; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D011247:Pregnancy; D018873:Pregnancy Rate
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D008596:Menotropins