title: Oestrogen receptor beta is not present in the pilosebaceous unit of red deer skin during the non-breeding season.
abstract: Androgens and oestrogens both have roles in skin physiology. Recently a second oestrogen receptor (ERbeta) has been identified in androgen-dependent tissues. The red deer grows a breeding season, androgen-dependent mane when plasma testosterone rises; this is replaced with small neck hairs during the non-breeding season. In non-breeding season deer skin, ERbeta was localised to the blood vessels and arrector pili muscle, but in contrast to human skin, not in the pilosebaceous unit or epidermis. The androgen receptor was not expressed. Further studies with breeding season skin may help to elucidate whether serum androgens or androgen receptor expression can modulate the expression of ERbeta in skin.
authors.affiliation: Department of Biomedical Sciences, University of Bradford, Bradford, UK. M.J.Thornton@bradford.ac.uk
authors.forename: M J
authors.initials: MJ
authors.lastname: Thornton
authors.forename: A H
authors.initials: AH
authors.lastname: Taylor
authors.forename: K
authors.initials: K
authors.lastname: Mulligan
authors.forename: F
authors.initials: F
authors.lastname: Al-Azzawi
mesh_terms: D000818:Animals; D003670:Deer / Q000378:metabolism* / Q000502:physiology; D004730:Endothelium, Vascular / Q000378:metabolism; D047629:Estrogen Receptor beta; D018859:Hair Follicle / Q000502:physiology; D008297:Male; D011960:Receptors, Estrogen / Q000378:metabolism*; D012098:Reproduction; D012621:Seasons; D012867:Skin / Q000098:blood supply / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen