title: A point mutation in CD45 may be associated with an increased risk of HIV-1 infection.
abstract: The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Here we show that abnormal CD45 splicing caused by a C77G transversion in exon A of the gene encoding CD45 (PTPRC) is associated with increased susceptibility to HIV-1 infection.
authors.affiliation: The Edward Jenner Institute for Vaccine Research, Compton, UK.
authors.forename: E Z
authors.initials: EZ
authors.lastname: Tchilian
authors.forename: D L
authors.initials: DL
authors.lastname: Wallace
authors.forename: R
authors.initials: R
authors.lastname: Dawes
authors.forename: N
authors.initials: N
authors.lastname: Imami
authors.forename: C
authors.initials: C
authors.lastname: Burton
authors.forename: F
authors.initials: F
authors.lastname: Gotch
authors.forename: P C
authors.initials: PC
authors.lastname: Beverley
mesh_terms: D017398:Alternative Splicing; D005091:Exons / Q000235:genetics; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D015497:HIV-1; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics* / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology; D017354:Point Mutation
chemical_list: D017493:Leukocyte Common Antigens