An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy.
A 32-year-old woman presenting with a rapidly progressive ALS-like syndrome was found to be HIV positive with a CD4 count of 44/mm(3). The patient recovered completely during 1 year after treatment with nelfinavir, zidovudine, and lamivudine, and recovery is sustained nearly 4 years later. Recovery was accompanied by HIV RNA becoming undetectable in plasma and CSF.
MacGowan
D J
DJ
Department of Neurology, Beth Israel Medical Center, New York, NY 10003, USA. dmacgow@bethisraelny.org
Scelsa
S N
SN
Waldron
M
M
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D016472:Motor Neuron Disease / Q000175:diagnosis / Q000188:drug therapy*; D019888:Nelfinavir / Q000627:therapeutic use; D009460:Neurologic Examination / Q000187:drug effects; D016896:Treatment Outcome; D015215:Zidovudine / Q000627:therapeutic use
D019380:Anti-HIV Agents; D019259:Lamivudine; D015215:Zidovudine; D019888:Nelfinavir