SW-163C and E, novel antitumor depsipeptides produced by Streptomyces sp. II. Structure elucidation.
SW-163C and E are novel antitumor antibiotics, which belong to quinomycin family, isolated from the culture broth of Streptomyces sp. SNA15896. These compounds were determined to be cyclic depsipeptides having 3-hydroxyquinaldic acid as a chromophore and a sulfur-containing intramolecular cross linkage through various spectroscopic analyses.
Takahashi
K
K
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan. k-takahashi@snowbrand.co.jp
Koshino
H
H
Esumi
Y
Y
Tsuda
E
E
Kurosawa
K
K
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D047630:Depsipeptides; D004448:Echinomycin / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008970:Molecular Weight; D010456:Peptides, Cyclic; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013053:Spectrophotometry; D013302:Streptomyces / Q000378:metabolism*; D013455:Sulfur / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; D010456:Peptides, Cyclic; C437363:SW-163C; C010777:quinomycin; D004448:Echinomycin; D013455:Sulfur