title: The use of regularity as estimated by approximate entropy to distinguish saltatory growth.
abstract: A nonlinear dynamics metric, approximate entropy (ApEn), is investigated as a diagnostic method for distinguishing between mathematical models, and the underlying mechanistic hypotheses that purport to describe the same time series experimental observations. ApEn measures the occurrence of pattern regularity within a time series, and is used here to investigate growth patterns in daily length growth. The notion investigated is that ApEn distributions for competing time series patterns expressed as mathematical formulations can be modelled by Monte Carlo and bootstrap methods and compared to the ApEn values for an original experimental data series. If the ApEn values for the different models do not overlap, then it is expected that ApEn can be utilized to distinguish these models and hypotheses, and to provide statistical assessment for the underlying biological patterns in experimental data. The conclusion is that the ApEn metric is successful as a time series diagnostic tool. It is a model-independent statistic that clearly differentiates saltatory growth from slowly varying continuous models of growth and serves to further document the saltatory nature of growth. This is a unique application of approximate entropy, illustrating the broad applicability of ApEn to biological time series, with the specific example of discriminating a saltatory growth process in longitudinal growth data. Future investigations of regularity in longitudinal time series in human biology with ApEn statistics are suggested.
authors.affiliation: Department of Pharmacology, National Science Foundation Science and Technology Center for Biological Timing, The University of Virginia Health System, Charlottesville 22908, USA. mlj8e@virginia.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Straume
authors.forename: M
authors.initials: M
authors.lastname: Lampl
mesh_terms: D003627:Data Interpretation, Statistical; D006128:Growth / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D010507:Periodicity; D013997:Time Factors