Evaluation of beta-cyclodextrin against natural infections of cryptosporidiosis in calves.
The effectiveness of beta-cyclodextrin, excipient used in pharmaceutical industry, in the treatment of natural infection by Cryptosporidium parvum in suckling calves, was evaluated. Administration of the drug at a dose of 500 mg/kg body weight for 3 consecutive days from birth (prophylactically) or following confirmation of the infection (therapeutically) decreased the severity of diarrhoea and shortened the duration of oocyst shedding.
Castro-Hermida
J A
JA
Laboratorio de Parasitología, Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Santiago de Compostela, Avda. de Vigo s/n, 15782 Santiago de Compostela, La Coruña, Spain.
González-Losada
Y
Y
Freire-Santos
F
F
Mezo-Menéndez
M
M
Ares-Mazás
E
E
D000818:Animals; D000833:Animals, Suckling; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use; D003457:Cryptosporidiosis / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D016785:Cryptosporidium parvum / Q000187:drug effects* / Q000254:growth & development; D003505:Cyclodextrins / Q000494:pharmacology / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D005243:Feces / Q000469:parasitology; D005260:Female; D008297:Male; D021261:Parasitic Sensitivity Tests / Q000662:veterinary; D047392:beta-Cyclodextrins
D003049:Coccidiostats; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; C031215:betadex