Synthesis, characterisation and antiamoebic activity of new thiophene-2-carboxaldehyde thiosemicarbazone derivatives and their cyclooctadiene Ru(II) complexes.
Reaction of new thiosemicarbazones (1-4) derived from thiophene-2-carboxaldehyde and cycloalkylaminothiocarbonylhydrazine with [Ru(eta(4)-C8H12)(CH3CN)2Cl2] leads to form complexes (1a-4a) of the type [Ru(eta(4)-C8H12)(TSC)Cl2] (where TSC=thiosemicarbazone). All the compounds have been characterised by elemental analysis, IR, 1H NMR, electronic spectra and thermogravimetric analysis. It is concluded that the thionic sulphur and the azomethine nitrogen atom of the ligands are bonded to the metal ion. In vitro antiamoebic screening against (HK-9) strain of Entamoeba histolytica indicated that the Ru(II) complexes of thiophene-2-carboxaldehyde thiosemicarbazones were found more active than the thiosemicarbazones.
Shailendra
N S
NS
Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, Jamia Nagar, India.
Bharti
N
N
Gonzalez Garza
M T
MT
Cruz-Vega
D E
DE
Castro Garza
J
J
Saleem
K
K
Naqvi
F
F
Azam
A
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004748:Entamoeba histolytica / Q000187:drug effects; D021261:Parasitic Sensitivity Tests; D012428:Ruthenium / Q000737:chemistry; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000981:Antiprotozoal Agents; D013882:Thiosemicarbazones; D012428:Ruthenium