title: PKB/AKT: functional insights from genetic models.
abstract: Since its discovery 10 years ago, the potential functions of protein kinase B (PKB)/AKT have been catalogued with increasing efficiency. The physiological relevance of some of the proposed mechanisms by which PKB/AKT mediates many of its effects has been questioned, and recent work using new reagents and approaches has revealed some cracks in our understanding of this important molecule, and also hinted that these effects may involve other players.
authors.affiliation: Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
authors.forename: M P
authors.initials: MP
authors.lastname: Scheid
authors.forename: J R
authors.initials: JR
authors.lastname: Woodgett
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D004789:Enzyme Activation; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D008969:Molecular Sequence Data; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity
chemical_list: D029721:Drosophila Proteins; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; C494918:AKT1 protein, human; C494917:Akt1 protein, Drosophila