title: Paralytic poliomyelitis associated with the Sabin 3 revertant strain of poliovirus in Bahrain.
abstract: We report a case of vaccine-associated paralytic poliomyelitis (VAPP) in Bahrain. The case occurred in an 8-week-old infant who had received a dose of oral polio vaccine (OPV) 7 days after birth. She was in contact with two vaccinees who had received OPV during the national immunisation campaign conducted 10 days before her birth. Specimens from the infant were sent to the WHO Collaborating Centre for Virus Reference and Research Laboratory for serological testing and virus detection, including genomic sequencing. Clinical and virological features are presented of a case of VAPP caused by the Sabin 3 strain of poliovirus that had reverted towards neurovirulence. The case represents one in 51,879 first doses of OPV distributed between 1995 and 1998. In order to reduce further the risk of VAPP, the dose of OPV at birth has been discontinued and a sequential schedule of inactivated polio vaccine (IPV) followed by OPV will be recommended.
authors.affiliation: Ministry of Health, State of Bahrain, Arabian Gulf. khalfans@batelco.com.bh
authors.forename: S A
authors.initials: SA
authors.lastname: Khalfan
authors.forename: J J
authors.initials: JJ
authors.lastname: Chomel
authors.forename: L
authors.initials: L
authors.lastname: Mallet
authors.forename: E
authors.initials: E
authors.lastname: Fernandes
authors.forename: A I
authors.initials: AI
authors.lastname: Lahlou
authors.forename: B
authors.initials: B
authors.lastname: Lina
authors.forename: M
authors.initials: M
authors.lastname: Aymard
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis; D005260:Female; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D011051:Poliomyelitis / Q000209:etiology* / Q000276:immunology / Q000821:virology; D017955:Poliovirus / Q000276:immunology / Q000302:isolation & purification; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*; D014773:Virology / Q000379:methods
chemical_list: D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral