Lack of association between polymorphisms of the coagulation factor VII and myocardial infarction in middle-aged Spanish men.
In order to determine the role of two polymorphisms in the factor VII gene (R353Q and intron 7 hypervariable region) in the susceptibility to develop early myocardial infarction, a total of 175 patients with acute myocardial infarction aged 50 years or less (mean age 41+/-7 years) and 200 controls (average age 42+/-6) without cardiovascular disease were genotyped for these polymorphisms. Gene and genotype frequencies did not differ between patients and controls. Although the 353-QQ genotype was at a higher frequency among controls (4%) compared to patients (1%), the difference did not reach statistical significance. Carriers of the H7-allele (intron 7 polymorphism) were at a slightly higher frequency among patients (51 vs. 43%; P=0.19; OR=1.36; 95% CI=1.09-1.70). Our data suggest a lack of association between both polymorphisms in the factor VII gene and early myocardial infarction in our population.
Batalla
A
A
Department of Cardiology, Hospital de Cabueñes, 33394 Cabueñes, Gijón, Asturias, Spain. abatalla@telecable.es
Alvarez
R
R
Reguero
J R
JR
González
P
P
Alvarez
V
V
Cubero
G I
GI
Cortina
A
A
Coto
E
E
D000328:Adult; D003327:Coronary Disease / Q000235:genetics*; D005167:Factor VII / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D016017:Odds Ratio; D017354:Point Mutation; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013030:Spain
D005819:Genetic Markers; D005167:Factor VII