HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.
Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.
Semenza
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McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. gsemenza@jhmi.edu
D000818:Animals; D029742:Caenorhabditis elegans Proteins; D015687:Cell Hypoxia; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D015801:Helminth Proteins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors
D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; C403074:Egl-9 protein, C elegans; C497442:HIF1A protein, human; D015801:Helminth Proteins; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014157:Transcription Factors; D011393:Procollagen-Proline Dioxygenase; D010100:Oxygen