title: Adrenomedullin and proadrenomudullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect.
abstract: The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E. coli. The results suggest that the novel vasoactive peptides AM and PAMP play an important role in mucosal defence.
authors.affiliation: First Department of Pathology, Miyazaki Medical College, Miyazaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Marutsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Nawa
authors.forename: Y
authors.initials: Y
authors.lastname: Asada
authors.forename: S
authors.initials: S
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: T
authors.initials: T
authors.lastname: Eto
authors.forename: A
authors.initials: A
authors.lastname: Sumiyoshi
mesh_terms: D053607:Adrenomedullin; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D003106:Colon / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000737:chemistry* / Q000166:cytology; D010446:Peptide Fragments / Q000032:analysis* / Q000494:pharmacology; D010455:Peptides / Q000032:analysis* / Q000494:pharmacology; D011506:Proteins / Q000032:analysis* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000032:analysis / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010446:Peptide Fragments; D010455:Peptides; D011506:Proteins; D014665:Vasodilator Agents; D053607:Adrenomedullin