title: Gliclazide-induced hepatitis, hemiplegia and dysphasia in a suicide attempt.
abstract: The drugs used to treat diabetes mellitus are diverse and include several classes. One class is sulfonylureas which primarily cause serum glucose reduction by stimulating the release of preformed insulin from the pancreatic islets. Gliclazide, a second generation sulfonylurea, is used to control glycemic levels in non-insulin-dependent diabetes mellitus. We report a 14 year-old non-diabetic girl who developed hepatitis, hemiplegia and dysphasia after ingestion of an overdose of gliclazide (20 mg/kg/day) in a suicide attempt. Our purpose is to draw attention to the severity of gliclazide-induced neurological signs. To the best of our knowledge, gliclazide-induced hemiplegia and dysphasia have not been previously reported in the literature.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey. huseyincaksen@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Caksen
authors.forename: M
authors.initials: M
authors.lastname: Kendirci
authors.forename: A
authors.initials: A
authors.lastname: Tutuş
authors.forename: K
authors.initials: K
authors.lastname: Uzüm
authors.forename: S
authors.initials: S
authors.lastname: Kurtoğlu
mesh_terms: D000293:Adolescent; D001037:Aphasia / Q000139:chemically induced*; D056486:Chemical and Drug Induced Liver Injury; D004569:Electroencephalography; D005260:Female; D005907:Gliclazide / Q000506:poisoning*; D006429:Hemiplegia / Q000139:chemically induced*; D006801:Humans; D007004:Hypoglycemic Agents / Q000506:poisoning*; D013406:Suicide, Attempted; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007004:Hypoglycemic Agents; D005907:Gliclazide