title: Effect of ApoE and tau on age of onset of progressive supranuclear palsy and multiple system atrophy.
abstract: In addition to allelic association between genetic polymorphisms and diseases, modulation of age of onset is a well recognised effect of disease susceptibility genes. The ApoE epsilon4 allele is associated with an earlier age of onset of sporadic and familial Alzheimer's disease. It has been suggested that the tau genotype influences the age of onset of progressive supranuclear palsy (PSP), a form of atypical parkinsonism caused by tau neurofibrillary tangle deposition. We have therefore analysed the relationship between tau and ApoE genotypes and the age of onset of PSP and another form of atypical parkinsonism, multiple system atrophy (MSA). We have not found any effect of possession of the tau H1 haplotype or the ApoE epsilon4 allele on the age of onset of MSA or PSP.
authors.affiliation: Neurogenetics Section, University Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: H R
authors.initials: HR
authors.lastname: Morris
authors.forename: A
authors.initials: A
authors.lastname: Schrag
authors.forename: U
authors.initials: U
authors.lastname: Nath
authors.forename: D
authors.initials: D
authors.lastname: Burn
authors.forename: N P
authors.initials: NP
authors.lastname: Quinn
authors.forename: S
authors.initials: S
authors.lastname: Daniel
authors.forename: N W
authors.initials: NW
authors.lastname: Wood
authors.forename: A J
authors.initials: AJ
authors.lastname: Lees
mesh_terms: D017668:Age of Onset; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000235:genetics* / Q000378:metabolism; D013494:Supranuclear Palsy, Progressive / Q000235:genetics* / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D016875:tau Proteins