title: [Effect of human recombinant granulocyte colony-stimulating factor on mouse hematopoietic and lymphoid organs].
abstract: Experiments on intact CBA/CALac mice demonstrated that single (1.25 mg/kg) and repeated (0.125 and 1.25 mg/kg, 30 days) injections of recombinant human granulocyte colony stimulation factor lead to reversible dose-dependent granulocyte lineage hyperplasia in bone marrow, regenerative neutrophilic leukocytosis, and thrombocytosis in peripheric blood and to splenic granulo-, erythro-, and thrombocytopoiesis more expressed in males.
authors.affiliation: Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
authors.forename: G V
authors.initials: GV
authors.lastname: Karpova
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.forename: E A
authors.initials: EA
authors.lastname: Timina
authors.forename: E V
authors.initials: EV
authors.lastname: Abramova
authors.forename: V I
authors.initials: VI
authors.lastname: Masycheva
authors.forename: N M
authors.initials: NM
authors.lastname: Pustoshilova
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007958:Leukocyte Count; D008221:Lymphoid Tissue / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size; D011994:Recombinant Proteins; D012737:Sex Factors; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor