Spironolactone and captopril attenuates isoproterenol-induced cardiac remodelling in rats.
The role of renin-angiotensin-aldosterone system in cardiac remodelling was studied in isoproterenol-induced cardiac hypertrophy in rats. The effects of captopril and spironolactone were compared. Isoproterenol treatment increased ventricular to body weight ratio (4.6 vs 3.7) and collagen area (22.6 vs 8.2%), and reduced systolic (89.93 vs 107.5 mm Hg) and diastolic (59.6 vs 70.8 mm Hg) pressure. In these animals, captopril decreased systolic (67.4 mm Hg) and diastolic pressure (31.9 mm Hg), whereas spironolactone regressed systolic pressure to control values (101.2 mm Hg). Captopril and spironolactone prevented cardiac hypertrophy (4.01 and 3.95). However, only spironolactone prevented myocardial fibrosis (11.3%).
Gallego
M
M
Department of Physiology, School of Pharmacy, University of the Basque Country, Spain. mongallego@yahoo.es
Espiña
L
L
Vegas
L
L
Echevarria
E
E
Iriarte
M M
MM
Casis
O
O
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D006332:Cardiomegaly / Q000139:chemically induced / Q000517:prevention & control*; D003094:Collagen / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004719:Endomyocardial Fibrosis / Q000139:chemically induced / Q000517:prevention & control*; D006352:Heart Ventricles / Q000187:drug effects; D007545:Isoproterenol; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013148:Spironolactone / Q000494:pharmacology*; D020257:Ventricular Remodeling / Q000187:drug effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D013148:Spironolactone; D003094:Collagen; D002216:Captopril; D007545:Isoproterenol