[Genetic study of psoriasis in the Kharkov population].
By means of genetic analysis of 400 individuals suffering from psoriasis the mendelian inheritance model have been rejected: the segregation frequencies are SFNxN = 0.083 and SFNxA = 0.1474. The heritability of psoriasis in the polygenic model is about 100%. The main gene model with incomplete penetration have been proposed (p = 0.044, [symbol: see text]1 = 6.1%, [symbol: see text]2 = 82.2%). 0.189% residents of Kharkov population are homozygotes and 8.32% heterozygotes on psoriatic gene, 0.155% residents are suffering from psoriasis heterozygotes and 0.508% heterozygotes. Among individuals suffering from psoriasis 23% are homozygotes and 77% heterozygotes.
Atramentova
L A
LA
Ryzhko
P P
PP
Fedota
A M
AM
D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008957:Models, Genetic; D020412:Multifactorial Inheritance; D010375:Pedigree; D019683:Penetrance; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D014455:Ukraine / Q000453:epidemiology