[Effect of stearoylethanolamine on composition of various classes of lipids in rat heart tissue under ischemia-reperfusion].
The effect N-stearoilethanolamines on lipide classes and their fatty acid composition was studied in the isolated rat heart under ischemia--reperfusion. It was shown that the amount of cholesterol esters increased at ischemia--reperfusion by 4.6 fold. The addition of 10(-7) M, 10(-6) M and 10(-5) M of N-stearoilethanolamines into perfused solution prevented these negative consequences of the myocardium ischemic injury. The addition of N-stearoilethanolamines decreased the quantity oleinic (18:1 omega 9) and free n-6 fatty acids. N-stearoilethanolamine lowered the amount of short chain saturated fatty acids and also polyunsaturated n-6 fatty acids in cholesterol esters. As well the lipide composition of perfused solutions was also investigated.
Artamonov
M V
MV
Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv.
Hula
N M
NM
Klimashevs'kyĭ
V M
VM
Zhukov
O D
OD
Marhitych
V M
VM
Frol'kys
V V
VV
D000818:Animals; D002784:Cholesterol / Q000737:chemistry*; D004983:Ethanolamines / Q000494:pharmacology*; D005227:Fatty Acids / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism*; D013229:Stearic Acids / Q000494:pharmacology*
D004983:Ethanolamines; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; C408368:N-stearoylethanolamine; D013229:Stearic Acids; D002784:Cholesterol