title: Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens.
abstract: Antibody isotypic responses (IgE, IgA, IgG1, IgG2, IgG3 and IgG4) to Schistosoma japonicum antigens--adult worm (AWA), soluble egg (SEA) and the recombinant proteins TEG (22.6-kDa tegumental antigen, Sj22) and PMY (paramyosin, Sj97)--were measured (in 1998) in a cohort of 179 Chinese subjects 2 years post-treatment. Subjects in the highest intensity re-infection group (> 100 eggs per gram faeces) had significantly higher levels of IgG1 and IgG4 against AWA. Analysis of IgG4/IgE ratios for AWA and SEA linked IgG4 excess to re-infection and IgE excess to non-re-infection. Two years after chemotherapeutic cure, 29 subjects, who were re-infected or never infected but highly water-exposed, were classified as epidemiologically susceptible (n = 15) or epidemiologically insusceptible to infection (n = 14). IgG4 levels against native antigens (AWA and SEA) were higher in susceptible and IgE levels were higher in insusceptible but antibody responses to the recombinant proteins (PMY and TEG) showed no clear pattern or difference between susceptibility groups. These and earlier findings provide evidence that immunity develops against schistosomiasis japonica in China and that susceptibility/resistance correlates with antibody isotypes against native schistosome antigens.
authors.affiliation: Molecular Parasitology Unit, Tropical Health Programme, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: A C
authors.initials: AC
authors.lastname: Sleigh
authors.forename: A G
authors.initials: AG
authors.lastname: Ross
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: G M
authors.initials: GM
authors.lastname: Williams
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.forename: M
authors.initials: M
authors.lastname: Tanner
authors.forename: D P
authors.initials: DP
authors.lastname: McManus
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000918:Antibody Specificity / Q000276:immunology*; D000947:Antigens, Helminth / Q000032:analysis; D015153:Blotting, Western; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D011223:Praziquantel / Q000627:therapeutic use; D015995:Prevalence; D012549:Schistosoma japonicum / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D017678:Sex Distribution
chemical_list: D000871:Anthelmintics; D000947:Antigens, Helminth; D011223:Praziquantel