Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities.
The antiinflammatory and antipyretic activities of the petroleum ether extract (PEE), dichloromethane extract (DME) and methanol extract (ME1) of the aerial part of Psoralea glandulosa L. (Papilionaceae) were studied. The bioactivity-guided fractionation of the active extracts yielded the isolation of bakuchiol (Bk) from the petroleum ether as the active compound, cyclobakuchiols A and B (Cbk), and angelicin (Ang) from DME.
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Laboratory of Pharmacognosy, Faculty of Pharmaceutical and Chemical Sciences, University of Chile, PO Box 233, 1-, Santiago, Chile.
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Negrete
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Erazo
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Zuñiga
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D018712:Analgesics, Non-Narcotic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D004987:Ethers; D005260:Female; D006168:Guinea Pigs; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D000432:Methanol; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D029907:Psoralea / Q000737:chemistry*; D011817:Rabbits; D012997:Solvents
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004987:Ethers; D010936:Plant Extracts; D012997:Solvents; D000432:Methanol