title: Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada.
abstract: A phytochemical analysis of the leaves of Aglaia dasyclada collected in Yunnan Province (People's Republic of China) yielded five cyclopentabenzofurans (1-5) of the rocaglamide family that are common secondary metabolites of Aglaia species as well as four biogenetically related compounds of the aglain (7), aglaforbesin (8) and forbaglin (9, 10) types. In addition, the cinnamic acid amide dasyclamide (6), which is a putative biogenetic precursor of these compounds (7-10), was isolated. The structures of the new compounds (6-10) were assigned unambiguously from the combined use of 1D and 2D NMR spectroscopy and mass spectrometry.
authors.affiliation: Institut für Pharmazeutische Biologie, Heinrich Heine Universität Düsseldorf, Universitätsstrasse 1, Gebäude 26.23, D-40225 Düsseldorf, Germany.
authors.lastname: Chaidir
authors.forename: W H
authors.initials: WH
authors.lastname: Lin
authors.forename: R
authors.initials: R
authors.lastname: Ebel
authors.forename: R A
authors.initials: RA
authors.lastname: Edrada
authors.forename: V
authors.initials: V
authors.lastname: Wray
authors.forename: M
authors.initials: M
authors.lastname: Nimtz
authors.forename: W
authors.initials: W
authors.lastname: Sumaryono
authors.forename: P
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D002942:Circular Dichroism; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011700:Putrescine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018411:Spodoptera / Q000187:drug effects / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; D006027:Glycosides; D007306:Insecticides; C107772:rocaglamide; D011700:Putrescine