title: Interstitial brachytherapy using iridium-192 for malignant brain tumors: clinical results.
abstract: OBJECTIVE
  To determine the effects and toxicity of interstitial brachytherapy using iridium-192 on brain malignant gliomas.
  
  
  METHODS
  Between January 1992 and January 1995, 56 patients with anaplastic astrocytoma and glioblastoma multiforme were treated with stereotactic brachytherapy using temporary high-activity iridium-192 sources.
  
  
  RESULTS
  The median survival for patients receiving brachytherapy was 28 months. The survival rates at 1, 2, 3 years were 92.8%, 83.9% and 71.4% respectively.
  
  
  CONCLUSIONS
  Brachytherapy may improve the control of local tumor and prolong the survival, when used in deep malignant brain gliomas, by temporary implanted high doses of iridium-192 sources.
authors.affiliation: Neurosurgical Center of PLA, Department of Neurosurgery, Navy General Hospital, Beijing.
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Cui
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.forename: Z
authors.initials: Z
authors.lastname: Yuan
authors.forename: J
authors.initials: J
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000401:mortality / Q000532:radiotherapy*; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D005909:Glioblastoma / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013238:Stereotaxic Techniques; D015996:Survival Rate
chemical_list: D007496:Iridium Radioisotopes