Late seizure recurrence after multiple subpial transections.
We studied long-term outcome (range, 28-89 months; mean, 56 months) after multiple subpial transections (MST) for medically refractory epilepsy. Forty-three (79.6%) of 54 patients had a consistent significant reduction in seizure frequency, and 27 (50%) of the 54 were either entirely seizure free or virtually so. However, 10 (18.5%) patients sustained an increase in seizure frequency several years after surgery, after showing initial postoperative improvement. This suggests that late seizure recurrence is a more important problem in cases in which MST has been performed than for pure resections.
Orbach
D
D
Department of Neurology, NYU School of Medicine, New York, New York, USA.
Romanelli
P
P
Devinsky
O
O
Doyle
W
W
D002540:Cerebral Cortex / Q000601:surgery*; D015331:Cohort Studies; D018572:Disease-Free Survival; D004827:Epilepsy / Q000175:diagnosis / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D019635:Neurosurgical Procedures / Q000379:methods / Q000706:statistics & numerical data; D012008:Recurrence; D013702:Temporal Lobe / Q000601:surgery; D016896:Treatment Outcome