title: [CD7(+) acute myeloid leukemia (M0) associated with a mediastinal bulky mass lesion].
abstract: A 41-year-old man visited his doctor in May 2000 because of a sore throat and high fever. His symptoms did not improve, despite administration of antibiotics and nonsteroidal anti-inflammatory drugs. Since a chest X-ray examination revealed an anterior mediastinal bulky tumor, he was referred and admitted to our hospital on June 21, 2000. The peripheral white blood cell count was 44,540/microliter with 74% myeloblasts. Bone marrow aspiration revealed a hypercellular marrow with 82% myeloblasts, which were negative for peroxidase and alpha-naphthyl butylate esterase staining. Blast cells were positive for CD7, CD13, CD33, CD34, and HLA-DR, and negative for CD56. A needle biopsy specimen of the mediastinal tumor consisted of myeloblasts. We diagnosed the patient as having CD7 (+) acute myeloid leukemia (AML) (M0) with a bulky mediastinal mass based on the surface marker analysis, although the clinical features resembled myeloid/NK precursor acute leukemia. The patient achieved a complete remission after two courses of induction therapy. We are planning an allogeneic stem cell transplantation during his first remission because of the high risk of relapse.
authors.affiliation: First Department of Internal Medicine, Saitama Medical School.
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Kusumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Sugahara
authors.forename: F
authors.initials: F
authors.lastname: Yagasaki
authors.forename: T
authors.initials: T
authors.lastname: Sakata
authors.forename: N
authors.initials: N
authors.lastname: Kawai
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Hirashima
authors.forename: H
authors.initials: H
authors.lastname: Kayano
authors.forename: M
authors.initials: M
authors.lastname: Bessho
mesh_terms: D000328:Adult; D019011:Antigens, CD7 / Q000032:analysis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage; D003937:Diagnosis, Differential; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009378:Neoplasms, Multiple Primary; D012074:Remission Induction
chemical_list: D019011:Antigens, CD7; D003561:Cytarabine; D015255:Idarubicin