The alkaloids of Artabotrys uncinatus.
A novel type of alpha,beta-butenolide alkaloid, uncinine (1), two novel oxoaporphines, artabonatine C (2) and artabonatine D (3), a new oxazoloaporphine, artabonatine E (4), and a new 7,7'-bisdehydroaporphine, artabonatine F (5), along with 25 known alkaloids, were isolated from Artabotrys uncinatus. The structures of 1-5 were determined using NMR and mass spectral data. Atherospermidine and squamolone exhibited cytotoxicity against hepatocarcinoma cancer cell lines (Hep G(2) and 2,2,15), and the activity of some of the alkaloids in an antithrombin assay is also discussed.
Hsieh
T J
TJ
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Chang
F R
FR
Chia
Y C
YC
Chen
C Y
CY
Lin
H C
HC
Chiu
H F
HF
Wu
Y C
YC
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029061:Annonaceae / Q000737:chemistry*; D000991:Antithrombins / Q000378:metabolism; D001060:Aporphines / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D005340:Fibrinogen / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D008968:Molecular Conformation; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013624:Taiwan; D013917:Thrombin / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000991:Antithrombins; D001060:Aporphines; D007546:Isoquinolines; D010975:Platelet Aggregation Inhibitors; D011166:Porphyrins; C438400:artabonatine C; C438399:artabonatine D; C438398:artabonatine E; C438397:artabonatine F; C438401:uncinine; C064684:atherospermidine; D005340:Fibrinogen; D006493:Heparin; D013917:Thrombin