title: A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations.
abstract: An important quality of meta-analytic models for research synthesis is their ability to account for both within- and between-study variability. Currently available meta-analytic approaches for studies of diagnostic test accuracy work primarily within a fixed-effects framework. In this paper we describe a hierarchical regression model for meta-analysis of studies reporting estimates of test sensitivity and specificity. The model allows more between- and within-study variability than fixed-effect approaches, by allowing both test stringency and test accuracy to vary across studies. It is also possible to examine the effects of study specific covariates. Estimates are computed using Markov Chain Monte Carlo simulation with publicly available software (BUGS). This estimation method allows flexibility in the choice of summary statistics. We demonstrate the advantages of this modelling approach using a recently published meta-analysis comparing three tests used to detect nodal metastasis of cervical cancer.
authors.affiliation: Group Health Cooperative, Center for Health Studies, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, USA. rutter.c@ghc.org
authors.forename: C M
authors.initials: CM
authors.lastname: Rutter
authors.forename: C A
authors.initials: CA
authors.lastname: Gatsonis
mesh_terms: D003198:Computer Simulation; D003952:Diagnostic Imaging / Q000592:standards*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008220:Lymphography; D008279:Magnetic Resonance Imaging; D008390:Markov Chains; D015201:Meta-Analysis as Topic; D015233:Models, Statistical; D009010:Monte Carlo Method; D012372:ROC Curve; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis