title: Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy.
abstract: HIV-associated distal sensory polyneuropathy (DSP) is a common complication of AIDS. No effective treatment is available. The authors investigated the long-term effect (48 weeks) of the neurotrophin nerve growth factor (NGF) in an open-label study of 200 subjects with HIV-associated DSP. Similar to their previously reported double-blind study, the authors showed that NGF was safe and well tolerated and significantly improved pain symptoms. However, there was no improvement of neuropathy severity as assessed by neurologic examination, quantitative sensory testing, and epidermal nerve fiber density.
authors.affiliation: Department of Neurology, University of Rochester, NY 14642, USA. gschifitto@mct.rochester.edu
authors.forename: G
authors.initials: G
authors.lastname: Schifitto
authors.forename: C
authors.initials: C
authors.lastname: Yiannoutsos
authors.forename: D M
authors.initials: DM
authors.lastname: Simpson
authors.forename: B T
authors.initials: BT
authors.lastname: Adornato
authors.forename: E J
authors.initials: EJ
authors.lastname: Singer
authors.forename: H
authors.initials: H
authors.lastname: Hollander
authors.forename: C M
authors.initials: CM
authors.lastname: Marra
authors.forename: M
authors.initials: M
authors.lastname: Rubin
authors.forename: B A
authors.initials: BA
authors.lastname: Cohen
authors.forename: T
authors.initials: T
authors.lastname: Tucker
authors.forename: I J
authors.initials: IJ
authors.lastname: Koralnik
authors.forename: D
authors.initials: D
authors.lastname: Katzenstein
authors.forename: B
authors.initials: B
authors.lastname: Haidich
authors.forename: M E
authors.initials: ME
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Shriver
authors.forename: L
authors.initials: L
authors.lastname: Millar
authors.forename: D B
authors.initials: DB
authors.lastname: Clifford
authors.forename: J C
authors.initials: JC
authors.lastname: McArthur
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D006801:Humans; D020932:Nerve Growth Factor / Q000008:administration & dosage*; D010147:Pain Measurement; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000821:virology; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D011994:Recombinant Proteins; D020932:Nerve Growth Factor