Nickel-promoted alkylative or arylative carboxylation of alkynes.
[reaction: see text]. Nickel-promoted alkylative or arylative carboxylation of terminal alkynes via a carbon dioxide fixation process was investigated. In the presence of a stoichiometric amount of a zero-valent nickel complex, the reaction of alkynes with CO2 gave a nickelacycle, which was reacted with various organozinc reagents under very mild conditions to provide beta,beta'-disubstituted, alpha,beta-unsaturated carboxylic acids in a highly regio- and stereoselective manner.
Takimoto
M
M
Graduate School of Pharmaceutical Scieneces, Hokkaido University, Sapporo 060-0812, Japan.
Shimizu
K
K
Mori
M
M