title: Behavioural and functional anatomical correlates of deception in humans.
abstract: Brain activity in humans telling lies has yet to be elucidated. We developed an objective approach to its investigation, utilizing a computer-based interrogation and fMRI. Interrogatory questions probed recent episodic memory in 30 volunteers studied outside and 10 volunteers studied inside the MR scanner. In a counter-balanced design subjects answered specified questions both truthfully and with lies. Lying was associated with longer response times (p < 0.001) and greater activity in bilateral ventrolateral prefrontal cortices (p < 0.05, corrected). These findings were replicated using an alternative protocol. Ventrolateral prefrontal cortex may be engaged in generating lies or withholding the truth.
authors.affiliation: SCANLab, Academic Department of Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Spence
authors.forename: T F
authors.initials: TF
authors.lastname: Farrow
authors.forename: A E
authors.initials: AE
authors.lastname: Herford
authors.forename: I D
authors.initials: ID
authors.lastname: Wilkinson
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
authors.forename: P W
authors.initials: PW
authors.lastname: Woodruff
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001931:Brain Mapping; D008192:Deception; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008014:Lie Detection / Q000523:psychology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests / Q000592:standards; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*