title: Malacoplakia simulating organ invasion in a rectosigmoid adenocarcinoma: report of a case.
abstract: Malacoplakia is a histiocytic inflammatory response that may be associated with colorectal tumors. We report the case of a 65-year-old male taking steroids for a severe pulmonary disease. He presented with a rectosigmoid tumor that seemed to infiltrate the urinary bladder and the sacrum on the preoperative CT scan and echography and at laparotomy. A low anterior resection en bloc with a partial cystectomy was performed. The pathologic analysis showed a pT3pN0 adenocarcinoma with an extensive malacoplakia infiltrating the bladder and the pericolic and perirectal tissues. This case report emphasizes the overstaging that malacoplakia may induce and underlines a situation the surgeon may possibly confront. Our observation confirms the association of malacoplakia, colorectal carcinoma, and steroid treatment.
authors.affiliation: Service de Chirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Matter
authors.forename: C
authors.initials: C
authors.lastname: Gygi
authors.forename: M
authors.initials: M
authors.lastname: Gillet
authors.forename: S
authors.initials: S
authors.lastname: Gebhard
authors.forename: H
authors.initials: H
authors.lastname: Bouzourene
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D000368:Aged; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D006801:Humans; D007249:Inflammation; D008171:Lung Diseases / Q000188:drug therapy; D008287:Malacoplakia / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D013256:Steroids / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000556:secondary* / Q000601:surgery
chemical_list: D013256:Steroids