Free radical oxidation and antioxidant activity in blood plasma and myocardium during long-term dipyridamole treatment.
Activation of free radical oxidation and inhibition of antioxidant activity in mouse myocardium after long-term dipyridamole treatment were demonstrated using chemiluminescent techniques. At the same time, dipyridamole 10-fold inhibited free radical oxidation and slightly increased antioxidant activity in the plasma. Dipyridamole-induced platelet disaggregation was accompanied by an increase in platelet count.
Ivasenko
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IN
Laboratory of Hematology, Institute of Cardiovascular Diseases, I. P. Pavlov State Medical University, St. Petersburg.
Shlyakhto
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EV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D004176:Dipyridamole / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013997:Time Factors
D000975:Antioxidants; D005609:Free Radicals; D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole