title: Synthesis and antibacterial activity of 5- and 6-hydroxy substituted 4-aminoquinolines and derivatives.
abstract: The synthesis and antimicrobial activity of 4-amino-8-methylquinolines 8, 11 substituted with a hydroxy- or methoxy-group at 5- and at 6-position have been investigated. The title compounds could be prepared by a six-step procedure according to the literature starting from commercially available anilines 1. The novel 4-aminoquinolines 8,11 exhibited slight antibacterial activity against Gram-positive and Gram-negative bacteria.
authors.affiliation: Institute of Pharmacy, University of Hamburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Meyer
authors.forename: T
authors.initials: T
authors.lastname: Lemcke
authors.forename: D
authors.initials: D
authors.lastname: Geffken
authors.forename: P M
authors.initials: PM
authors.lastname: Kaulfers
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D011804:Quinolines