title: A statistical analysis of nucleotide substitutions in the Drosophila Adh region reflects irregularities in molecular clocks.
abstract: Substitutions rates are expected to be rather constant when a gene is compared between species. To analyze this feature, Ka/Ks ratios have been studied for Alcohol dehydrogenase (Adh) and Alcohol dehydrogenase duplication (Adh-dup) genes in Drosophila species. Adh Ka/Ks values are lower in intrasubgenus comparisons involving species of the Sophophora group than when these species are compared to the D. immigrans and S. lebanonensis, and this difference does not occur in the Adh-dup comparisons.
authors.affiliation: Department de Genètica, Facultat de Biologia. Universitat de Barcelona, Spain. albalat@porthos.bio.ub.es
authors.forename: R
authors.initials: R
authors.lastname: Albalat
authors.forename: C
authors.initials: C
authors.lastname: Arenas
authors.forename: F
authors.initials: F
authors.lastname: Mestres
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000818:Animals; D001482:Base Composition; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004330:Drosophila / Q000201:enzymology* / Q000235:genetics*; D019143:Evolution, Molecular; D020440:Gene Duplication; D017344:Genes, Insect; D013045:Species Specificity; D013997:Time Factors
chemical_list: D004247:DNA; D000426:Alcohol Dehydrogenase