Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes.
Contribution of Vgamma9/Vdelta2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vgamma9/Vdelta2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vgamma9/Vdelta2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vgamma9/Vdelta2 T lymphocytes, play a major role, which indicates that Vgamma9/Vdelta2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.
Dieli
F
F
Dipartimento di Biopatologia, Università di Palermo, Palermo, Italy.
Troye-Blomberg
M
M
Ivanyi
J
J
Fournié
J J
JJ
Krensky
A M
AM
Bonneville
M
M
Peyrat
M A
MA
Caccamo
N
N
Sireci
G
G
Salerno
A
A
D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D013601:T-Lymphocytes / Q000382:microbiology*; D014376:Tuberculosis / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; C075005:GNLY protein, human; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta