The immunology of HIV-infected long-term non-progressors--a current view.
Long-term non-progressors (LTNP) are human immunodeficiency virus (HIV)-infected individuals characterized by the absence of disease, low viral loads and stable or even increasing CD4(+) T cell counts for prolonged periods of time. In these subjects, an HIV-specific immune response which is either stronger or directed against a wider array of viral epitopes than that seen in progressors, can be often detected. Here, we summarize the characteristics of HIV-specific CD4(+) and CD8(+) T cell responses in LTNP, and discuss how a highly effective T cell-mediated immune response against HIV might contribute to the establishment of this particular condition.
Paroli
M
M
Fondazione Andrea Cesalpino c/o Dipartimento di Medicina Interna, Università di Roma La Sapienza, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Propato
A
A
Accapezzato
D
D
Francavilla
V
V
Schiaffella
E
E
Barnaba
V
V
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006678:HIV / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D020276:HIV Long-Term Survivors; D015789:HLA-A2 Antigen; D006801:Humans; D007156:Immunologic Memory; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015789:HLA-A2 Antigen