Standard deviations and correlations of GC levels in DNA sequences.
In a DNA sequence that exhibits long-range correlations, standard deviations among the GC levels of its segments can be up to an order of magnitude higher than in a sequence consisting of independent, identically distributed nucleotides. Conversely, plots of inter-segment standard deviations vs. segment length reveal quantitative information about the correlations present in a sequence. We present and discuss formulae that relate long-range (power-law) correlations between the nucleotides of a sequence to the expected standard deviations of the GC levels of its segments, and to the correlations between them.
Clay
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Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Naples, Italy. clay@infobiogen.fr
D000818:Animals; D001482:Base Composition; D004247:DNA / Q000235:genetics*; D020862:GC Rich Sequence / Q000235:genetics*; D016678:Genome; D006801:Humans; D017422:Sequence Analysis, DNA / Q000379:methods; D013223:Statistics as Topic
D004247:DNA