Epstein-Barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilians in São Paulo.
The proportion of Epstein-Barr virus-associated gastric carcinoma (EBV-GC) was examined in 149 Japanese-Brazilian and 151 non-Japanese-Brazilian gastric-carcinoma cases using in situ hybridization (ISH) assay to detect EBV-encoded small RNA (EBER), and the results were compared with our referent Japanese data. We found that 4.7% of cases in Japanese Brazilians were EBER-positive. This frequency was slightly lower than that of the referent Japanese, among whom 6.2% of 2038 gastric-carcinoma cases were EBER-positive. On the other hand, the non-Japanese-Brazilian series showed a significantly higher proportion of EBV-GC (11.2%) than the referent group did (P = 0.01). Although EBV-GC was predominant in males among non-Japanese Brazilians (M / F = 3.6, P = 0.047), as was the case in Japanese (M / F = 2.7), Japanese Brazilians did not show such a male predominance. The sex-ratio difference between the Japanese Brazilians and Japanese was statistically significant (P = 0.005). In conclusion, the present study in Japanese Brazilians and Japanese yielded no evidence suggesting any change in the frequency of EBV-GC caused by migration, except the absence of male predominance, which was observed both in Japanese and non-Japanese Brazilians.
Koriyama
C
C
Department of Public Health, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan. fiy@m.kufm.kagoshima-u.ac.jp
Akiba
S
S
Iriya
K
K
Yamaguti
T
T
Hamada
G S
GS
Itoh
T
T
Eizuru
Y
Y
Aikou
T
T
Watanabe
S
S
Tsugane
S
S
Tokunaga
M
M
D000230:Adenocarcinoma / Q000208:ethnology* / Q000473:pathology / Q000821:virology; D000328:Adult; D000368:Aged; D044383:Black People; D001938:Brazil / Q000453:epidemiology; D015897:Comorbidity; D020031:Epstein-Barr Virus Infections / Q000208:ethnology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D017403:In Situ Hybridization; D007564:Japan / Q000208:ethnology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies; D017678:Sex Distribution; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000473:pathology / Q000821:virology; D014505:Urban Population; D044465:White People
C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral