Gastric mucosal endogenous prostacyclin levels are different in Brattleboro rats compared with Wistar strain.
Homozygous Brattleboro rats were investigated and compared to normal (physiological) Wistar strain rats regarding their gastric mucosal endogenous prostacyclin (PG-I(2)) level. It seems that the Brattleboro animals have a significantly lower level of this important protective material. Wistar rats having an artificial pituitary stalk lesion (which is the artificial equivalent of homozygous Brattleboro animals) showed no differences in endogenous mucosal prostacyclin level compared to normal Wistar rats. Therefore, we concluded that this hitherto unknown property of the homozygous Brattleboro rats is genetically determined.
Balint
G A
GA
Laboratory of Clinical Pharmacology, Department of Psychiatry, New Clinics, Medical Faculty, University of Szeged, Szeged, Hungary. balint@nepsy.szote.u-szeged.hu
Galfi
M
M
Juhasz
A
A
Laszló
F A
FA
Rimanóczy
A
A
D000818:Animals; D011464:Epoprostenol / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro / Q000378:metabolism*; D017208:Rats, Wistar / Q000378:metabolism*
D011464:Epoprostenol