NSAID-related gastrointestinal injury. Evidence-based approach to a preventable complication.
NSAID-induced gastrointestinal mucosal injury and its subsequent complications are a tremendously important clinical problem. Effective prophylactic and treatment strategies involve proton pump inhibitors, misoprostol, or selective COX-2 inhibitors. These agents are capable of dramatically decreasing or eliminating the risk of mucosal injury as well as the morbidity and mortality for this disorder. Identification of the at-risk patient and initiation of appropriate preventive therapy are the keys to minimizing the societal burden of this disease process.
Fennerty
M B
MB
Division of Gastroenterology, Mail Code PV-310, Oregon Health and Science University School of Medicine, 3181 SW Sam Jackson Park Rd, Portland, OR 97201-3098, USA. fennerty@ohsu.edu
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000517:prevention & control
D000894:Anti-Inflammatory Agents, Non-Steroidal