Screening for mutations of the androgen receptor gene in patients with isolated cryptorchidism.
OBJECTIVE
To evaluate the occurrence of mutations of androgen receptor (AR) gene in patients with isolated cryptorchidism.


METHODS
Controlled clinical study.


METHODS
Yamagata University Hospital, Yamagata and Tokyo Electric Power Company Hospital, Tokyo, Japan.


METHODS
Patients with isolated cryptorchidism (n = 48) and a control group of men with normal phenotype (n = 20).


METHODS
Blood (lymphocyte DNA).


METHODS
Screening of the AR gene in exons 1-8 using single-strand conformational polymorphism analysis.


RESULTS
No abnormal band patterns were detected in patients with cryptorchidism or in control subjects within the eight exons of the AR gene.


CONCLUSIONS
AR gene alterations appear to be an unlikely cause of isolated cryptorchidism.
Suzuki
Y
Y
Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.
Sasagawa
I
I
Ashida
J
J
Nakada
T
T
Muroya
K
K
Ogata
T
T
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D008297:Male; D009154:Mutation; D018807:Polymorphism, Single-Stranded Conformational; D011944:Receptors, Androgen / Q000235:genetics*; D012016:Reference Values
D011944:Receptors, Androgen