Effect of the dipeptide vilon on activity of digestive enzyme in rats of various ages.
Peroral administration of Vilon (Lys-Glu) to male and female Wistar rats aging 3 and 11 months changed activity of digestive enzymes (invertase, maltase, alkaline phosphatase, and amino- and dipeptidases) in various portions of the gastrointestinal tract. The increase in enzyme activity was most pronounced in 11-month-old animals, which diminished differences between rats of various ages. Our results indicate that Vilon produces positive effects on digestive enzyme activity during aging.
Khavinson
V K
VK
St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences. vvm@medport.ru
Timofeeva
N M
NM
Malinin
V V
VV
Egorova
V V
VV
Nikitina
A A
AA
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism; D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D004064:Digestive System / Q000187:drug effects / Q000201:enzymology*; D004150:Dipeptidases / Q000378:metabolism; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006026:Glycoside Hydrolases / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000520:alpha-Glucosidases / Q000378:metabolism; D043324:beta-Fructofuranosidase
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D000469:Alkaline Phosphatase; D006026:Glycoside Hydrolases; D000520:alpha-Glucosidases; D043324:beta-Fructofuranosidase; D000626:Aminopeptidases; D004150:Dipeptidases; C415909:lysylglutamic acid