Knockout models resulting in the development of obesity.
Our understanding of body weight regulation has been greatly advanced by the characterization of previously existing mutations in mice that cause obesity. Subsequent analysis of a number of mouse knockout models has greatly expanded the number of genes known to influence adiposity by affecting metabolic rate, physical activity, and/or appetite.
Butler
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Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA.
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D000818:Animals; D004195:Disease Models, Animal; D012739:Gonadal Steroid Hormones / Q000235:genetics; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009478:Neuropeptide Y / Q000235:genetics; D018377:Neurotransmitter Agents / Q000235:genetics; D009765:Obesity / Q000209:etiology / Q000235:genetics*; D011333:Pro-Opiomelanocortin / Q000235:genetics; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics; D018043:Receptors, Corticotropin / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D044101:Receptors, Melanocortin; D017476:Receptors, Neuropeptide Y / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D012739:Gonadal Steroid Hormones; D009478:Neuropeptide Y; D018377:Neurotransmitter Agents; D022702:Receptors, Adrenergic, beta-3; D018043:Receptors, Corticotropin; D018160:Receptors, Cytoplasmic and Nuclear; D044101:Receptors, Melanocortin; D017476:Receptors, Neuropeptide Y; D014157:Transcription Factors; D011333:Pro-Opiomelanocortin