title: Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival.
abstract: Three important results concerning the shape and the trends of the human mortality rate were discussed recently in demographic and epidemiological literature. These are the deceleration of the mortality rate at old ages, the tendency to rectangularization of the survival curve, and the decline of the old age mortality observed in the second part of the 20th century. In this paper we show that all these results can be explained by using a model with a new type of heterogeneity associated with individual differences in adaptive capacity. We first illustrate the idea of such a model by considering survival in a mixture of two subpopulations of individuals (called "labile" and "stable"). These subpopulations are characterized by different Gompertz mortality patterns, such that their mortality rates cross over. The survival chances of individuals in these subpopulations have different sensitivities to changes in environmental conditions. Then we develop a more comprehensive model in which the mortality rate is related to the adaptive capacity of an organism. We show that the trends in survival patterns experienced by a mixture of such individuals resemble those obtained in an analysis of empirical data on survival in developed countries. Lastly, we present evidence of the existence of subpopulations of phenotypes in both humans and experimental organisms, which were used as prototypes in our models. The existence of such phenotypes provides the possibility that at least part of today's centenarians originated from an initially frail part of the cohort.
authors.affiliation: Max Planck Institute for Demographic Research, Rostock, Germany. yashin@demogr.mpg.de
authors.forename: A I
authors.initials: AI
authors.lastname: Yashin
authors.forename: S V
authors.initials: SV
authors.lastname: Ukraintseva
authors.forename: G
authors.initials: G
authors.lastname: De Benedictis
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
authors.forename: A A
authors.initials: AA
authors.lastname: Butov
authors.forename: K
authors.initials: K
authors.lastname: Arbeev
authors.forename: D A
authors.initials: DA
authors.lastname: Jdanov
authors.forename: S I
authors.initials: SI
authors.lastname: Boiko
authors.forename: A S
authors.initials: AS
authors.lastname: Begun
authors.forename: M
authors.initials: M
authors.lastname: Bonafe
authors.forename: C
authors.initials: C
authors.lastname: Franceschi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D016330:Frail Elderly; D006801:Humans; D008019:Life Style; D008136:Longevity / Q000235:genetics*; D008297:Male; D008962:Models, Theoretical; D009026:Mortality / Q000639:trends*; D011336:Probability; D018570:Risk Assessment; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications*; D016019:Survival Analysis