[Effects of praeruptorin C on cardiac dysfunction, myocardial compliance and collagen content in renovascular hypertensive rats].
The effects of praeruptorin C (Pra-C) on cardiac dysfunction, myocardial compliance, and collagen content in renovascular hypertensive rats have been studied. In rats with left ventricular hypertrophy (LVH), the ratio of cardiac flow (CF)/heart wet weight (HWW) and cardiac output (CO)/HWW decreased by 20.1% and 35.5%; LVSP and -dp/dtmax decreased by 19.4% and 42.1%, while LVEDP and T value were increased by 186.4% and 226%. The left ventricular diastolic pressure-volume (P-V) curve was shifted to the left and down ward compared with that of sham-operated rats. The hydroxyproline content was 5.93 +/- 0.82 mg.g-1 dry weight in the left ventricular myocardial tissue of rats with LVH which was higher than that of sham-operated rats(e.g. 4.01 +/- 0.47 mg.g-1). The content did not change in the right ventricular myocardium. After treated with Pra-C for nine weeks, the CF/HWW and CO/HWW increased by 31.3% and 25.1%, the LVSP and -dp/dtmax increased by 16.7% and 27.8%. The LVEDP and T value was reduced by 34.9% and 36.5%, respectively, compared with those of LVH. The P-V curves of these rats were shifted to the right and in the up-ward direction. The hydroxyproline content was 4.52 +/- 0.3 mg.g-1 dry weight in the left ventricular tissue. These results indicate that Pra-C improved the cardiac contractility and relaxation by increasing the coronary flow and cardiac output, and decreasing the collagen content in the ventricular myocardium.
Sun
L
L
Department of Cardiovascular Pharmacology, Nanjing Medical University, Nanjing 210029.
Rao
M R
MR
Liu
P Q
PQ
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism*; D003374:Coumarins / Q000494:pharmacology*; D006334:Heart Function Tests; D006909:Hydroxyproline / Q000378:metabolism; D006978:Hypertension, Renovascular / Q000378:metabolism / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism / Q000503:physiopathology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D002121:Calcium Channel Blockers; D003374:Coumarins; C058808:praeruptorin C; D003094:Collagen; D006909:Hydroxyproline