title: Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole.
abstract: The activities of amphotericin B and itraconazole were studied in a temporarily neutropenic murine model of disseminated Absidia corymbifera infection, caused by two different strains. Amphotericin B MICs were 0.25 mg/L for both strains and itraconazole MICs were 1 and 2 mg/L. Amphotericin B was effective in vivo with both isolates. Itraconazole was less effective.
authors.affiliation: School of Medicine, Section of Infectious Diseases, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, UK.
authors.forename: J
authors.initials: J
authors.lastname: Mosquera
authors.forename: P A
authors.initials: PA
authors.lastname: Warn
authors.forename: J L
authors.initials: JL
authors.lastname: Rodriguez-Tudela
authors.forename: D W
authors.initials: DW
authors.lastname: Denning
mesh_terms: D020095:Absidia / Q000145:classification / Q000187:drug effects*; D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods; D009091:Mucormycosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B