A short and efficient route to novel scyphostatin analogues.
[structure: see text]. Several novel scyphostatin analogues have been prepared in up to 18% yield over five steps from commercially available 4-bromoguaiacol, utilizing an organometallic addition to afford the desired syn-hydroxy-epoxides.
Runcie
K A
KA
Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Taylor
R J
RJ
D000577:Amides / Q000138:chemical synthesis*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry; D011753:Pyrones / Q000138:chemical synthesis*; D013108:Sphingomyelin Phosphodiesterase / Q000037:antagonists & inhibitors
D000577:Amides; D004791:Enzyme Inhibitors; D009942:Organometallic Compounds; D011753:Pyrones; C121123:scyphostatin; D013108:Sphingomyelin Phosphodiesterase