title: 2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides.
abstract: 2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified.
authors.affiliation: GlaxoSmithKline, 5Moore Drive, Research Triangle Park, NC 27709, USA. mjb45288@glaxowellcome.com
authors.forename: M J
authors.initials: MJ
authors.lastname: Bishop
authors.forename: J
authors.initials: J
authors.lastname: Berman
authors.forename: E C
authors.initials: EC
authors.lastname: Bigham
authors.forename: D T
authors.initials: DT
authors.lastname: Garrison
authors.forename: M J
authors.initials: MJ
authors.lastname: Gobel
authors.forename: S J
authors.initials: SJ
authors.lastname: Hodson
authors.forename: P E
authors.initials: PE
authors.lastname: Irving
authors.forename: J A
authors.initials: JA
authors.lastname: Liacos
authors.forename: D J
authors.initials: DJ
authors.lastname: Minick
authors.forename: F
authors.initials: F
authors.lastname: Navas
authors.forename: D L
authors.initials: DL
authors.lastname: Saussy
authors.forename: J D
authors.initials: JD
authors.lastname: Speake
mesh_terms: D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000737:chemistry / Q000494:pharmacology*; D000577:Amides / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D000577:Amides; D002264:Carboxylic Acids; D004952:Esters; D007093:Imidazoles