Fatal rhabdomyolysis after acute sodium monensin (Rumensin) toxicity: case report.
Myoglobinuria or rhabdomyolysis occurs when myoglobin escapes into the blood and then into the urine after acute muscle necrosis. It can be a serious medical condition leading to renal failure and death. There are many causes including exertion, crush syndromes, ischaemia, metabolic disorders, exogenous toxins and drugs, heat stroke and hereditary disorders such as malignant hyperthermia. We report the case of a 17 year-old boy who developed myoglobinuria, renal failure and death 11 days after ingesting sodium monensin, possibly with the intention of developing muscles. Sodium monensin, the active principle of Rumensin(R), is a dietary additive used as a growth promoter for confined cattle. There are no previous reports of human intoxication. Accidental or experimental sodium monensin intoxication in animals produces similar findings to those seen in this case.
Kouyoumdjian
J A
JA
Neuromuscular and Electromyography Division, Department of Neurological Sciences, Faculdade de Medicina de Ribeirão Preto, São Jose do Rio Preto, SP, Brazil. jaris@terra.com.br
Morita
M P
MP
Sato
A K
AK
Pissolatti
A F
AF
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced; D000293:Adolescent; D017809:Fatal Outcome; D005503:Food Additives / Q000506:poisoning*; D006801:Humans; D008297:Male; D008985:Monensin / Q000506:poisoning*; D024510:Muscle Development / Q000187:drug effects*; D012206:Rhabdomyolysis / Q000139:chemically induced*
D005503:Food Additives; D008985:Monensin