title: Recurrent cervical carcinoma after radical hysterectomy: an analysis of clinical aspects and prognosis.
abstract: Samlal RAK, van der Velden J, van Eerden T, Schilthuis MS, Gonzalez Gonzalez D, Lammes FB. Recurrent cervical carcinoma after radical hysterectomy: an analysis of clinical aspects and prognosis. Int J Gynecol Cancer 1998; 8: 78-84. The purpose of the present study was to evaluate the clinical aspects and prognosis of patients with tumor recurrence in surgically treated stage IB and IIA cervical carcinoma patients. Two hundred and seventy-one stage IB and IIA cervical carcinoma patients underwent a Wertheim Okabayashi radical hysterectomy with pelvic lymphadenectomy. The median follow-up time was 60 months. Recurrence occurred in 27 patients (10%): 14 had a pelvic recurrence and 13, and extrapelvic recurrence. The site of recurrence was influenced by various pathological factors as well as by the primary treatment mode. 77% of recurrences were detected within three years after primary treatment. The median recurrence-free interval in patients with a pelvic recurrence was significantly shorter than in patients with an extrapelvic recurrence (14 months vs. 17 months, P = 0.03). The mortality rate of the group of patients with recurrent disease was 85% (23/27). Patients with a pelvic central recurrence had a significantly better outcome than did patients whose recurrences were located at the pelvic sidewall. Two patients with a pulmonary recurrence were treated with surgery and show no evidence of disease after 4 and 8 years respectively, of follow-up. The overall detection rate of recurrent disease by routine follow-up was only 36%. However, asymptomatic patients had a significantly better prognosis when compared with symptomatic patients. Therefore, we recommend frequent follow-up visits during the first 3 years after primary treatment to detect recurrence in an early stage.
authors.affiliation: Departments of Obstetrics and Gynecology; Radiotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, TheNetherlands.
authors.forename: R. A. K.
authors.initials: RA
authors.lastname: Samlal
authors.forename: J.
authors.initials: J
authors.lastname: Van Der Velden
authors.forename: T.
authors.initials: T
authors.lastname: Van Eerden
authors.forename: M. S.
authors.initials: MS
authors.lastname: Schilthuis
authors.forename: D.
authors.initials: D
authors.lastname: Gonzalez Gonzalez
authors.forename: F. B.
authors.initials: FB
authors.lastname: Lammes