Modified dinucleoside tetraphosphonates, new potential inhibitors of HIV reverse transcriptase.
New gamma-substituted analogues of dNTP were synthesized and their enzymatic stability and antiviral properties were evaluated.
Shirokova
E A
EA
Engelhardt Instiute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov St., Moscow 117984, Russia.
Khandazhinskaya
A L
AL
Skoblov
Y S
YS
Goryunova
L Y
LY
Beabealashvilli
R S
RS
Krayevsky
A A
AA
D000818:Animals; D019380:Anti-HIV Agents / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D015226:Dinucleoside Phosphates / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D004355:Drug Stability; D005347:Fibroblasts / Q000821:virology; D006678:HIV / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D008979:Moloney murine leukemia virus / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D018894:Reverse Transcriptase Inhibitors / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*
D019380:Anti-HIV Agents; D015226:Dinucleoside Phosphates; D018894:Reverse Transcriptase Inhibitors