Reduced-glutathione concentrations in Boleophthalmus pectinirostris tissues exposed to benzo(a)pyrene.
The concentrations of reduced-glutathione (GSH) in liver and ovary of Boleophthalmus pectinirostris are quantified. The concentrations of GSH in the ovary are much higher than that of GSH in the liver(nearly 3 times of the liver). The study also investigates the changes of GSH contents in the two organs while the fishes were exposed to benzo(a)pyrene(BaP) at concentrations of 0, 0.05, 0.2 and 0.5 mg/L respectively for up to a week. The concentrations of GSH in the liver of BaP-exposed fish increased significantly with dose, whereas the concentrations of GSH in the ovary decreased significantly compared to controls. The results suggested that both the liver and the ovary are the primary organ in BaP metabolism, and that the changes of GSH levels may represent an adaptive response or toxic effect to BaP exposure.
Feng
T
T
Environmental Science Research Center, Xiamen University, Xiamen 361005, China.
Zheng
W Y
WY
Guo
X Q
XQ
Zhang
Y
Y
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D010473:Perciformes; D014874:Water Pollutants, Chemical
D014874:Water Pollutants, Chemical; D001564:Benzo(a)pyrene; D005978:Glutathione