title: A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK).
abstract: [structure: see text]. A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.
authors.affiliation: Center for Supramolecular Science and Department of Chemistry, University of Miami, PO Box 249118, Coral Gables, Florida 33124, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Zheng
authors.forename: Q
authors.initials: Q
authors.lastname: Huo
authors.forename: P
authors.initials: P
authors.lastname: Kele
authors.forename: F M
authors.initials: FM
authors.lastname: Andreopoulos
authors.forename: S M
authors.initials: SM
authors.lastname: Pham
authors.forename: R M
authors.initials: RM
authors.lastname: Leblanc
mesh_terms: D000873:Anthracenes / Q000138:chemical synthesis; D015374:Biosensing Techniques; D003300:Copper / Q000032:analysis*; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D019216:Metals, Heavy / Q000032:analysis; D009842:Oligopeptides / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence
chemical_list: D000873:Anthracenes; D019216:Metals, Heavy; D009842:Oligopeptides; C020905:glycyl-histidyl-lysine; C010030:9-anthroic acid; D003300:Copper