title: Oligonucleotides containing a lysine residue as 3'-3' junction for alternate strand triple helix formation.
abstract: Oligonucleotides with a 3'-3' inversion of polarity site assured by one lysine residue have been synthesized, characterized and used as third strands in alternate strand triple helix formation. UV melting studies and molecular mechanics calculations have been carried out to investigate the stability and the geometry of these new triplexes.
authors.affiliation: Dipartimento di Chimica, Università di Napoli "Federico II", Via Cinthia, 4, Complesso Universitario di Monte S. Angelo, I-80126, Napoli, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Barone
authors.forename: L
authors.initials: L
authors.lastname: De Napoli
authors.forename: G
authors.initials: G
authors.lastname: Di Fabio
authors.forename: C
authors.initials: C
authors.lastname: Giancola
authors.forename: A
authors.initials: A
authors.lastname: Messere
authors.forename: D
authors.initials: D
authors.lastname: Montesarchio
authors.forename: L
authors.initials: L
authors.lastname: Petraccone
authors.forename: G
authors.initials: G
authors.lastname: Piccialli
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D004355:Drug Stability; D008239:Lysine / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D013057:Spectrum Analysis; D013696:Temperature
chemical_list: D009841:Oligonucleotides; C051802:triplex DNA; D004247:DNA; D008239:Lysine