Levobupivacaine combined with sufentanil and epinephrine for intrathecal labor analgesia: a comparison with racemic bupivacaine.
We performed a randomized, double-blinded study to compare levobupivacaine with racemic bupivacaine for labor analgesia. Eighty term parturients received either levobupivacaine 0.125% or racemic bupivacaine 0.125%, to which was added sufentanil 0.75 microg/mL and epinephrine 1.25 microg/mL. As part of a combined spinal-epidural procedure, 2 mL of this mixture was initially injected intrathecally, and the same solutions were subsequently administered epidurally. For both combinations, onset until the first painless contraction was 4 to 5 min. Most patients were pain free during the second contraction. The duration of initial spinal analgesia was 93.5 +/- 20 min and 94.7 +/- 31 min for levobupivacaine and racemic bupivacaine, respectively. The duration of analgesia for the first epidural top-up dose was also similar in the two groups. Total local anesthetic requirements during labor were not different. The only major difference observed was the absence of motor impairment in levobupivacaine-treated parturients as compared with the Racemic Bupivacaine group, in which the incidence of a Bromage-1 motor block was 34%. Other side effects and obstetric or neonatal outcomes were not different between groups. Intrathecal levobupivacaine has a similar clinical profile as racemic bupivacaine, but at equal doses it produced less motor block.


CONCLUSIONS
When used intrathecally and epidurally for labor analgesia, levobupivacaine had the same clinical profile as racemic bupivacaine, but at equal doses it produced less motor block.
Vercauteren
M P
MP
Department of Anesthesia, University Hospital Antwerp, Edegem, Belgium. marcel.vercauteren@uza.uia.ac.be
Hans
G
G
De Decker
K
K
Adriaensen
H A
HA
D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local / Q000737:chemistry; D002045:Bupivacaine / Q000737:chemistry; D004311:Double-Blind Method; D004837:Epinephrine; D005260:Female; D006340:Heart Rate, Fetal; D006801:Humans; D007278:Injections, Spinal; D010147:Pain Measurement / Q000187:drug effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D013237:Stereoisomerism; D017409:Sufentanil; D014590:Uterine Contraction / Q000187:drug effects; D014662:Vasoconstrictor Agents
D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D017409:Sufentanil; D002045:Bupivacaine; D004837:Epinephrine