DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions.
The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface.
Pöhlmann
S
S
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Leslie
G J
GJ
Edwards
T G
TG
Macfarlan
T
T
Reeves
J D
JD
Hiebenthal-Millow
K
K
Kirchhoff
F
F
Baribaud
F
F
Doms
R W
RW
D015704:CD4 Antigens / Q000032:analysis; D015815:Cell Adhesion Molecules; D006678:HIV / Q000502:physiology*; D016655:HIV Core Protein p24 / Q000032:analysis; D015658:HIV Infections / Q000635:transmission*; D006801:Humans; D037102:Lectins / Q000502:physiology*; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface / Q000502:physiology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015704:CD4 Antigens; D015815:Cell Adhesion Molecules; D016655:HIV Core Protein p24; D037102:Lectins; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C433029:CLEC4M protein, human