title: Severe abdominal infections in neutropenic patients.
abstract: Abdominal infections are an important cause of morbidity and mortality in neutropenic patients. We present a retrospective series of 16 patients, mostly with acute leukemia, who developed severe abdominal infections during chemotherapy-induced neutropenia between 1991 and 1997. The frequency among patients with acute leukemia was 2.35% (13 of 553). Thirteen patients presented with enterocolitis and 3 patients presented with cholecystitis. Eight patients died. Bacteremia was present in 6 patients, 4 patients suffered from proven or strongly suspected fungal infections, and 1 patient suffered from cytomegalovirus infection. Early surgical management was required in a patient with intestinal obstruction, whereas other patients could be managed conservatively. Two patients with acute cholecystitis were treated with antibiotics until the end of neutropenia and then were resected. Severe abdominal injections in neutropenic patients, which are often fatal, were caused by nonbacterial microorganisms in one-fourth of the cases and could be managed conservatively in most instances.
authors.affiliation: Department of Internal Medicine I, University of Bonn, Germany. gorschlueter@uni-bonn.de
authors.forename: M
authors.initials: M
authors.lastname: Gorschlüter
authors.forename: A
authors.initials: A
authors.lastname: Glasmacher
authors.forename: C
authors.initials: C
authors.lastname: Hahn
authors.forename: C
authors.initials: C
authors.lastname: Leutner
authors.forename: G
authors.initials: G
authors.lastname: Marklein
authors.forename: J
authors.initials: J
authors.lastname: Remig
authors.forename: I G
authors.initials: IG
authors.lastname: Schmidt-Wolf
authors.forename: T
authors.initials: T
authors.lastname: Sauerbruch
mesh_terms: D000005:Abdomen / Q000382:microbiology / Q000473:pathology; D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000209:etiology* / Q000473:pathology; D002764:Cholecystitis / Q000209:etiology* / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D016469:Fungemia / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D009503:Neutropenia / Q000150:complications*; D012189:Retrospective Studies