[Effect of novel anxiolytic agent aphobazole on coherence of the brain biopotentials in MR and MNRA rats].
Effect of the anxiolytic drugs afobazole, diazepam, and chlordiazepoxide on the cortical biopotential coherency was studied in MR and MNRA rats with increased and decreased level of emotionality, respectively. Afobazole increased a difference in the biopotential coherency between rats of the two lines in the range of EEG theta, alpha, and beta rhythms. In the subrange of dominating theta activity (6.00-7.25 Hz), this effect took place at the expense of reduced coherency in MNRA rats in the absence of changes in the MR line. Afobazole decreased the biopotential coherency in the alpha activity band (7.5-8.25 Hz) in the rats of both lines. This is indicative of the presence of a CNS-stimulating component in the pharmacological activity spectrum of afobazole. The expediency of using afobazole in patients with different levels of anxiety is discussed.
Kozhechkin
S N
SN
Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Sviderskaia
N E
NE
Korol'kova
T A
TA
Koshtoiants
O Kh
OKh
Kozhedub
R G
RG
Seredenin
S B
SB
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004569:Electroencephalography; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines