Intestinal regrowth is amplified after jejunal but not ileal resection during tapeworm infection in the rat.
The ileum possesses functions required by a healthy individual that are not fully supplanted by the duodenum or jejunum. Evidence suggests that the ileum may also be necessary to maintain an enteric parasite-host interaction. We hypothesized that the ileum is essential to the survival of the lumen-dwelling, rat tapeworm, H. diminuta. Male rats were divided into three groups: those with ileal or jejunal resections and nonresected controls. Half of each rat group was infected with the tapeworm. After jejunal resection, the weight but not length of intestinal remnant (duodenum + ileum) in infected rats returned to that of control, nonresected intestine 29 days after surgery and tapeworm numbers were fully maintained. In contrast, after ileal removal intestinal length and weight of the remaining duodenum and jejunum in infected rats were significantly decreased and tapeworm survival diminished. Data indicates that intestinal growth following resection is amplified by tapeworm infection when the ileum remains but diminished when the ileum is removed. Furthermore, loss of the ileum results in decreased infection intensity and dry weight of the tapeworm.
Dwinell
K L
KL
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA.
Bass
P
P
Oaks
J A
JA
D000818:Animals; D005769:Gastrointestinal Motility; D006925:Hymenolepiasis / Q000503:physiopathology* / Q000601:surgery; D007082:Ileum / Q000382:microbiology / Q000503:physiopathology* / Q000601:surgery; D007411:Intestinal Diseases, Parasitic / Q000503:physiopathology* / Q000601:surgery; D007583:Jejunum / Q000382:microbiology / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley