[Mathematical and simulating model of accelerated aging induced by 5-bromo-2-deoxyuridine].
The principles of stochastic modeling and simulation of the processes of aging and carcinogenesis by means of semimartingale methods are considered. The model fits to the experiments on activating of processes of aging be 5-bromodeoxiuridine postnatal exposure inducing genome instability. The model describes the multistage phenomena of aging and carcinogenesis by the system of stochastic equations in terms of multivariate and diffusion processes.
Butov
A A
AA
Ulyanovsk State University, 432700, Ulyanovsk, Lva Tolstogo St., 42. butov@mv.ru
Volkov
M A
MA
Anisimov
V N
VN
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D000963:Antimetabolites / Q000009:adverse effects*; D001973:Bromodeoxyuridine / Q000009:adverse effects*; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced; D017354:Point Mutation / Q000235:genetics; D013269:Stochastic Processes
D000963:Antimetabolites; D001973:Bromodeoxyuridine