title: Possible use of transrectal power Doppler imaging as an indicator of microvascular density of prostate cancer.
abstract: OBJECTIVE
  To reveal the possible use of transrectal power Doppler imaging (PDI) of the prostate in the assessment of the microvascular density (MVD) of cancer lesions.
  
  
  METHODS
  In 22 patients with clinically organ-confined prostate cancer, PDI was performed before radical prostatectomy and the degree of vascularity of the cancer lesions as evaluated by PDI was compared with the MVD determined on the surgical specimens. The vascularity by PDI of each cancer lesion was graded on a scale of DS0 to DS2, according to the degree of Doppler signal accumulation. MVD was obtained using factor VIII immunohistochemistry.
  
  
  RESULTS
  The vascularity of the PDI of 46 cancer lesions categorized 23 (50%), 10 (22%), and 13 (28%) cancer lesions as DS0, DS1, and DS2, respectively. Significant differences were found in the MVD between DS0 (46.6 +/- 26.8) and DS2 (89.0 +/- 18.1, P <0.005) lesions and between DS1 (50.9 +/- 25.4) and DS2 (P <0.001) lesions. The MVD of 30 cancer lesions in 13 patients without neoadjuvant therapy was significantly higher than that of the 16 lesions in 9 patients with therapy (70.2 +/- 28.2 versus 39.5 +/- 23.9, P <0.001). In the 13 patients without neoadjuvant therapy, the MVD of the DS2 lesions (89.1 +/- 18.9) was significantly higher than that of the DS0 lesions (59.3 +/- 32.5, P <0.01) and DS1 lesions (55.9 +/- 20.9, P <0.005).
  
  
  CONCLUSIONS
  The semiquantitative assessment of Doppler flow signals using PDI appears to be of clinical value as an indicator of MVD.
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakanouchi
authors.forename: K
authors.initials: K
authors.lastname: Okihara
authors.forename: M
authors.initials: M
authors.lastname: Kojima
authors.forename: O
authors.initials: O
authors.lastname: Ukimura
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Takamatsu
authors.forename: T
authors.initials: T
authors.lastname: Miki
mesh_terms: D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D012039:Regional Blood Flow; D014463:Ultrasonography