title: Seroconversion to HIV-1 following a needlestick injury despite combination post-exposure prophylaxis.
abstract: Post-exposure prophylaxis with antiretroviral drugs for at-risk needlestick injuries has become routine practice and is usually empirical. With increasing numbers of treatment-experienced patients, the choice of antiretroviral may need to be individually tailored. Infection can still occur despite attempts to optimize the drug combination used.
authors.affiliation: Stephen's Centre, Chelsea & Westminster Hospital, London, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Hawkins
authors.forename: D
authors.initials: D
authors.lastname: Asboe
authors.forename: K
authors.initials: K
authors.lastname: Barlow
authors.forename: B
authors.initials: B
authors.lastname: Evans
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000517:prevention & control*; D006679:HIV Seropositivity / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission*; D015497:HIV-1 / Q000276:immunology*; D006230:Hand Injuries / Q000150:complications*; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional; D008297:Male; D008875:Middle Aged; D016602:Needlestick Injuries / Q000150:complications*; D009727:Nurses, Male; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D019380:Anti-HIV Agents