title: Architecture of the optic chiasm and the mechanisms that sculpt its development.
abstract: At the optic chiasm the two optic nerves fuse, and fibers from each eye cross the midline or turn back and remain uncrossed. Having adopted their pathways the fibers separate to form the two optic tracts. Research into the architecture and development of the chiasm has become an area of increasing interest. Many of its mature features are complex and vary between different animal types. It is probable that numerous factors sculpt its development. The separate ganglion cell classes cross the midline at different locations along the length of the chiasm, reflecting their distinct periods of production as the chiasm develops in a caudo-rostral direction. In some mammals, uncrossed axons are mixed with crossed axons in each hemi-chiasm, whereas in others they remain segregated. These configurations are the product of different developmental mechanisms. The morphology of the chiasm changes significantly during development. Neurons, glia, and the signals they produce play a role in pathway selection. In some animals fiber-fiber interactions are also critical, but only where crossed and uncrossed pathways are mixed in each hemi-chiasm. The importance of the temporal dimension in chiasm development is emphasized by the fact that in some animals uncrossed ganglion cells are generated abnormally early in relation to their retinal location. Furthermore, in albinos, where many cells do not exit the cell cycle at normal times, there are systematic chiasmatic abnormalities in ganglion cell projections.
authors.affiliation: University College London, Institute of Ophthalmology, London, United Kingdom. g.jeffrey@ucl.ac.uk
authors.forename: G
authors.initials: G
authors.lastname: Jeffery
mesh_terms: D000417:Albinism / Q000473:pathology; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D053823:Hedgehog Proteins; D006801:Humans; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009897:Optic Chiasm / Q000033:anatomy & histology* / Q000254:growth & development* / Q000473:pathology / Q000502:physiology; D051762:PAX2 Transcription Factor; D012160:Retina / Q000033:anatomy & histology* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014795:Visual Pathways / Q000033:anatomy & histology* / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D053823:Hedgehog Proteins; D051762:PAX2 Transcription Factor; C497318:PAX2 protein, human; D015534:Trans-Activators; D014157:Transcription Factors