title: Surgical hepatosplenic mansonic schistosomiasis in adolescents: repercussions of the post-treatment schistosomotic burden on the hepatic functional reserve.
abstract: Schistosomiasis mansoni affects the hepatic functional reserve. Clinical treatment with oxamniquine is not 100% effective and there has been found strain of this parasite resistant to this drug. The aims of this investigation were: (1) to examine the presence of residual parasite burden after medical and surgical treatment on adolescents with surgical schistosomiasis mansoni and (2) to assess the effect on the hepatic functional reserve in patients with and without residual infection. Twenty nine children with hepatosplenic schistosomiasis mansoni and bleeding esophageal varices were treated with oxamniquine. They underwent splenectomy, ligature of the left gastric vein and autologous implantation of spleen tissue into the greater omentum. After a mean post-operative follow up of five years they underwent rectal biopsy for schistosomotic egg search. They were divided in patients with and without infection. In 20 patients the submucosal egg search was negative, however, in 9 it was positive. The hepatic functional reserve in the patients without infection was as follows: 17 were Child-Pugh A and 3 Child-Pugh B. In the patients who were still infected 6 were Child-Pugh A and 3 Child-Pugh B. The chi2 analysis of the hepatic functional reserve showed chi2 = 3.19 - p= 0.07. From the results the following conclusion can be drawn: residual infection or reinfection in the follow up period had not interfered with the distribution of the hepatic functional reserve of the patients in this series. However, there was a trend for a decrease of this parameter in patients with residual infection.
authors.affiliation: Hospital das Clínicas, Departamento de Cirurgia, CCS, UFPE, Recife, PE, 50670-420, Brasil. carlosbrandt@bol.com.br
authors.forename: C T
authors.initials: CT
authors.lastname: Brandt
authors.forename: M V
authors.initials: MV
authors.lastname: da Mota Braga
authors.forename: K L
authors.initials: KL
authors.lastname: Melo
authors.forename: H
authors.initials: H
authors.lastname: Pinho Sá
authors.forename: R
authors.initials: R
authors.lastname: Carvalheira
mesh_terms: D000293:Adolescent; D000818:Animals; D002648:Child; D004932:Esophageal and Gastric Varices / Q000188:drug therapy / Q000601:surgery; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008099:Liver / Q000469:parasitology / Q000502:physiology*; D008109:Liver Diseases, Parasitic / Q000188:drug therapy / Q000601:surgery*; D010073:Oxamniquine / Q000627:therapeutic use; D012007:Rectum / Q000469:parasitology; D012008:Recurrence; D012550:Schistosoma mansoni / Q000302:isolation & purification*; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000601:surgery*; D012556:Schistosomicides / Q000627:therapeutic use; D013158:Splenic Diseases / Q000188:drug therapy / Q000601:surgery*
chemical_list: D012556:Schistosomicides; D010073:Oxamniquine