Vascular cell adhesion molecule-1 as a biochemical marker of left ventricular mass in the patients with hypertension.
Plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), and E-selectin were measured in 80 outpatients with uncomplicated essential hypertension. Although the levels of E-selectin and sICAM-1 were similar between the patients with and without left ventricular (LV) hypertrophy, sVCAM-1 level was significantly elevated in the patients with LV hypertrophy (759.7+/-154.6 ng/mL nu 984.4+/-240.6 ng/mL, P < .0001). The LV mass normalized to body surface area or height were significantly correlated with sVCAM-1 (r=0.615, P < .0001 and r=0.571, P < .0001, respectively). These results indicate that a soluble adhesion molecule is correlated with LV mass in uncomplicated essential hypertensive patients.
Kuroda
Y T
YT
Osaka Second Police Hospital, Ibaraki, Japan.
Komamura
K
K
Tatsumi
R
R
Mori
K
K
Yoneda
K
K
Katayama
Y
Y
Shigemoto
S
S
Miyatake
K
K
Hanafusa
T
T
D000368:Aged; D000804:Angiotensin II / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D019040:E-Selectin / Q000097:blood; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications* / Q000000981:diagnostic imaging; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000150:complications* / Q000000981:diagnostic imaging; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D017539:Tunica Intima / Q000000981:diagnostic imaging; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D015415:Biomarkers; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D000804:Angiotensin II; D018799:Intercellular Adhesion Molecule-1