Early effects of cis-dichlorodiammine platinum (II) on tumor progression and programmed death of Ehrlich ascites carcinoma cells.
We studied the effects of cis-dichlorodiammine platinum (II) on different pathways of cell death in cultured Ehrlich ascites carcinoma in vitro and on subsequent growth of transplanted tumor in vivo. One-hour incubation with the cytostatic modulated apoptosis in cell culture. However, exposure of cell culture to a minimal effective concentration of cis-platinum(II)diammine dichloride promoted the growth of transplanted tumor.
Razin
B V
BV
International Research Center for Extreme Body States, Presidium of the Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences. inscience@mail.ru
Inzhevatkin
E V
EV
Nefedova
V V
VV
Egorova
A B
AB
Kazbanov
V I
VI
Nefedov
V P
VP
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D051379:Mice; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002945:Cisplatin