Effect of food reductones, 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF) and hydroxyhydroquinone (HHQ), on lipid peroxidation and type IV and I allergy responses of mouse.
The effect of long-term supplementation of food reductones, 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF) (2%, w/w), detected in many foodstuffs including soy sauce, and hydroxyhydroquinone (1,2,4-benzenetriol) (HHQ) (1.2%, w/w), detected in coffee, on mouse lipid peroxidation and type IV and I allergy responses was investigated. The effect of supplementation of these reductones combined with NO(2) inhalation (5-6 ppm) was also investigated. Levels of thiobarbituric acid-reactive substances in lung were remarkably increased, and those in kidney and liver were slightly decreased by supplementation of DMHF or HHQ. The degree of 2,4-dinitrochlorobenzene (DNCB)-sensitized lymph node cell proliferation as assessed by lymph node assay was remarkably enhanced by supplementation of DMHF or HHQ. Both the DNCB-sensitized and the trimellitic anhydride-sensitized increases in IgE levels of mice were enhanced to greater extent by supplementation of DMHF or HHQ. In no cases were additive effects of NO(2) inhalation observable. Allergen-sensitized type IV and I allergy responses of mice may be enhanced by supplementation of food reductones, DMHF or HHQ.
Mi
H
H
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan.
Hiramoto
K
K
Kujirai
K
K
Ando
K
K
Ikarashi
Y
Y
Kikugawa
K
K
D000818:Animals; D003069:Coffee / Q000737:chemistry; D003877:Dermatitis, Contact / Q000209:etiology*; D004032:Diet; D004137:Dinitrochlorobenzene / Q000276:immunology; D005504:Food Analysis; D005663:Furans / Q000008:administration & dosage / Q000009:adverse effects*; D006873:Hydroquinones / Q000008:administration & dosage / Q000009:adverse effects*; D007073:Immunoglobulin E / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009585:Nitrogen Dioxide / Q000008:administration & dosage; D010796:Phthalic Anhydrides / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000209:etiology*; D013025:Glycine max / Q000737:chemistry; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D003069:Coffee; D004137:Dinitrochlorobenzene; D005663:Furans; D006873:Hydroquinones; D010796:Phthalic Anhydrides; D017392:Thiobarbituric Acid Reactive Substances; C013038:hydroxyhydroquinone; C058427:furaneol; D007073:Immunoglobulin E; C015559:trimellitic anhydride; D009585:Nitrogen Dioxide