title: Geranins C and D, additional new antiprotozoal A-type proanthocyanidins from Geranium niveum.
abstract: Two new additional A-type proanthocyanidins have been isolated from Geranium niveum. Their structures were determined by spectroscopic, chemical and chiroptical methods as epi-afzelechin-(4beta-->8,2beta-->O-->7)-gallocatechin (1) and epi-afzelechin-(4beta-->8,2beta-->O-->7)-afzelechin-(4beta-->8,2beta-->O-->7)-afzelechin (2). Proanthocyanidins 1 and 2 were given the trivial names of geranins C and D, respectively. Compound 2 showed moderate antiprotozoal activity against Entamoeba histolytica and Giardia lamblia, whereas 1 exhibited weak activity toward E. histolytica.
authors.forename: F
authors.initials: F
authors.lastname: Calzada
authors.forename: R
authors.initials: R
authors.lastname: Cedillo-Rivera
authors.forename: R
authors.initials: R
authors.lastname: Bye
authors.forename: R
authors.initials: R
authors.lastname: Mata
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000737:chemistry / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004748:Entamoeba histolytica / Q000187:drug effects*; D016829:Giardia lamblia / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D008800:Mexico; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal; D044945:Proanthocyanidins
chemical_list: D000872:Anthocyanins; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D044945:Proanthocyanidins; C440103:geranin C; C440105:geranin D