Inflammatory myofibroblastic tumor with CNS involvement.
BACKGROUND
Inflammatory myofibroblastic tumors (IMT) represent a spectrum of neoplasms that occur in the mesentery and retroperitoneum and less frequently in the mediastinum of children and young adults. Transformation into inflammatory fibrosarcoma and metastases are rare.


METHODS
We report the case of a 16-year-old patient with an inflammatory myofibroblastic tumor of the mesentery with mediastinal metastases. Partial remission was obtained by chemotherapy with ifosfamide, dactinomycine, and vincristine. Two months later, relapse with infiltration of the meninges developed, and the patient died.


CONCLUSIONS
This case demonstrates unusual features of an IMT: presentation with metastases, excellent response to chemotherapy, dissemination to the CNS.
Trojan
A
A
Division of Oncology, Department of Internal Medicine, University Hospital Zurich, Switzerland.
Stallmach
T
T
Kollias
S
S
Pestalozzi
B C
BC
D000293:Adolescent; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008578:Meninges / Q000473:pathology; D008643:Mesentery / Q000473:pathology; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D014057:Tomography, X-Ray Computed