title: Management of common symptoms in terminally ill patients: Part II. Constipation, delirium and dyspnea.
abstract: In addition to pain, patients who are approaching the end of life commonly have other symptoms. Unless contraindicated, prophylaxis with a gastrointestinal motility stimulant laxative and a stool softener is appropriate in terminally ill patients who are being given opioids. Patients with low performance status are not candidates for surgical treatment of bowel obstruction. Cramping abdominal pain associated with mechanical bowel obstruction often can be managed with morphine (titrating the dosage for pain) and octreotide. Delirium is common at the end of life and is frequently caused by a combination of medications, dehydration, infections or hypoxia. Haloperidol is the pharmaceutical agent of choice for the management of delirium. Dyspnea, the subjective sensation of uncomfortable breathing, is often treated by titration of an opioid to relieve the symptom; a benzodiazepine is used when anxiety is a component of the breathlessness.
authors.affiliation: University of Maryland School of Medicine, Baltimore, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Ross
authors.forename: C S
authors.initials: CS
authors.lastname: Alexander
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D001569:Benzodiazepines; D002400:Cathartics / Q000627:therapeutic use; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology; D003693:Delirium / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D004417:Dyspnea / Q000188:drug therapy* / Q000209:etiology; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D010166:Palliative Care; D013727:Terminal Care
chemical_list: D000701:Analgesics, Opioid; D014151:Anti-Anxiety Agents; D000932:Antiemetics; D002400:Cathartics; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D006220:Haloperidol