title: Fat hedgehogs, slower or richer?
abstract: Hedgehog (Hh) is a protein ligand that is involved in early developmental patterning. The activity of Hh is controlled by cleavage events and various posttranslational modifications, including the addition of cholesterol and palmitic acid. Van den Heuvel describes how acylation of Hh affects the activity of the protein and explores the differences in activity between the vertebrate sonic hedgehog (Shh) and Drosophila Hh.
authors.affiliation: MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK, OX1 3QX. marcel.vandenheuvel@human-anatomy.oxford.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: van Den Heuvel
mesh_terms: D000215:Acylation; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D009068:Movement; D019308:Palmitic Acid / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins; D015534:Trans-Activators; C077245:hh protein, Drosophila; D019308:Palmitic Acid; D002784:Cholesterol