Shorter REM latency associated with more sleep cycles of a shorter duration in healthy humans.
A significant association between rapid eye movement (REM) sleep latency and the number of non-REM/REM sleep cycles was found 15 years ago in a large retrospective study. The present prospective study further explored this intra-sleep relationship and analyzed the links between these two variables and the mean cycle duration. It was based on a carefully selected group of healthy control subjects whose sleep was polysomnographically recorded at home for 4 sequential nights. The latency of REM sleep was inversely correlated with the number of cycles and positively correlated with the mean cycle duration, both in individual nights and on means of 4 nights. The present study demonstrated that variations in the number of cycles or the mean cycle duration between the nights are far less important than the substantial differences observed between subjects. Present outcomes support the study of sleep cycle periods and frequencies in those psychiatric disorders where REM sleep latencies have been found to be shorter, and they suggest that these variables be included in sleep studies in which cycles are compared with each other.
Le Bon
O
O
Sleep Center, Centre Hospitalier Universitaire Brugmann S48, Université Libre de Bruxelles, Place Van Gehuchten 4, B-1020 Brussels, Belgium. lebono@ulb.ac.be
Staner
L
L
Hoffmann
G
G
Kentos
M
M
Pelc
I
I
Linkowski
P
P
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011930:Reaction Time; D012016:Reference Values; D012894:Sleep Stages; D012895:Sleep, REM