Death signals changes in TFIID.
In this issue of Molecular Cell, Bell et al. identify an isoform of hTAF(II)80 that is induced in response to several proapoptotic stimuli. The finding that extracellular signals can lead to changes in the subunit composition of TFIID provides an example of how regulated activity of the general transcription factors may contribute to inducible programs of gene expression.
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Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D046911:Macromolecular Substances; D020033:Protein Isoforms / Q000378:metabolism; D035381:TATA-Binding Protein Associated Factors; D015534:Trans-Activators / Q000378:metabolism; D035362:Transcription Factor TFIID; D014157:Transcription Factors / Q000378:metabolism*; D019473:Transcription Factors, TFII / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology
D046911:Macromolecular Substances; D020033:Protein Isoforms; C084977:TAF6 protein, human; C106849:TAF9 protein, human; D035381:TATA-Binding Protein Associated Factors; D015534:Trans-Activators; D035362:Transcription Factor TFIID; D014157:Transcription Factors; D019473:Transcription Factors, TFII