title: Increased prevalence of class I integrons in Escherichia coli, Klebsiella species, and Enterobacter species isolates over a 7-year period in a German university hospital.
abstract: The prevalence of integrons in five enterobacterial species was analyzed in 900 blood culture isolates from 1993, 1996, and 1999. Remarkably, the prevalence increased from 4.7% in 1993 to 9.7% in 1996 and finally to 17.4% in 1999 (P < 0.01). Within 7 years the combined percentage of P1 strong promoters and P1 weak plus P2 active promoters with high transcription efficacies has increased from 23.1 to 33.3 and finally 60% (P < 0.05).
authors.affiliation: Institute for Medical Microbiology and Virology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany. schmitfj@uni-duesseldorf.de
authors.forename: F J
authors.initials: FJ
authors.lastname: Schmitz
authors.forename: D
authors.initials: D
authors.lastname: Hafner
authors.forename: R
authors.initials: R
authors.lastname: Geisel
authors.forename: P
authors.initials: P
authors.lastname: Follmann
authors.forename: C
authors.initials: C
authors.lastname: Kirschke
authors.forename: J
authors.initials: J
authors.lastname: Verhoef
authors.forename: K
authors.initials: K
authors.lastname: Köhrer
authors.forename: A C
authors.initials: AC
authors.lastname: Fluit
mesh_terms: D001769:Blood / Q000382:microbiology; D003470:Culture Media; D004251:DNA Transposable Elements; D004754:Enterobacter / Q000235:genetics / Q000302:isolation & purification; D004755:Enterobacteriaceae / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology*; D004926:Escherichia coli / Q000235:genetics / Q000302:isolation & purification; D005858:Germany / Q000453:epidemiology; D006785:Hospitals, University; D006801:Humans; D019426:Integrases / Q000235:genetics*; D007709:Klebsiella / Q000235:genetics / Q000302:isolation & purification; D015995:Prevalence
chemical_list: D003470:Culture Media; D004251:DNA Transposable Elements; D019426:Integrases