Mechanisms of HIV-1 nucleoside reverse transcriptase inhibitor resistance: is it all figured out?
The mechanistic basis for some examples of HIV-1 NRTI-resistance can be examined using altered incorporation of nucleoside analogs and surveying what is known about the more recently described mechanisms of chain-terminator removal. The complexity of these resistance mechanisms and the interplay with other factors that contribute to NRT1 resistance are only just beginning to be appreciated.
Naeger
L K
LK
Gilead Sciences Inc, Foster City, CA 94404, USA. lisa_naeger@gilead.com
Miller
M D
MD
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism; D019380:Anti-HIV Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D009154:Mutation; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000494:pharmacology; D012194:RNA-Directed DNA Polymerase / Q000737:chemistry / Q000235:genetics; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D018119:Stavudine / Q000494:pharmacology; D000068698:Tenofovir; D015215:Zidovudine / Q000494:pharmacology
D019380:Anti-HIV Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; D000255:Adenosine Triphosphate; D000068698:Tenofovir; D018119:Stavudine; D012194:RNA-Directed DNA Polymerase; D000225:Adenine