Adrenomedullin and proadrenomudullin N-terminal 20 peptide (PAMP) are present in human colonic epithelia and exert an antimicrobial effect.
The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E. coli. The results suggest that the novel vasoactive peptides AM and PAMP play an important role in mucosal defence.
Marutsuka
K
K
First Department of Pathology, Miyazaki Medical College, Miyazaki, Japan.
Nawa
Y
Y
Asada
Y
Y
Hara
S
S
Kitamura
K
K
Eto
T
T
Sumiyoshi
A
A
D053607:Adrenomedullin; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D003106:Colon / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000737:chemistry* / Q000166:cytology; D010446:Peptide Fragments / Q000032:analysis* / Q000494:pharmacology; D010455:Peptides / Q000032:analysis* / Q000494:pharmacology; D011506:Proteins / Q000032:analysis* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000032:analysis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010446:Peptide Fragments; D010455:Peptides; D011506:Proteins; D014665:Vasodilator Agents; D053607:Adrenomedullin