New uses of amino acids as chiral building blocks in organic synthesis.
[reaction: see text] N,N-Dibenzylamino aldehydes have emerged as a highly useful class of chiral building blocks in synthetic organic chemistry. We envisioned the transformation of the N,N -dibenzylamino aldehydes to the corresponding aldimines followed by diastereoselective methylene transfer with a sulfonium ylide to obtain alpha-amino aziridines in high yields.
Reetz
M T
MT
Max-Planck-Institute for Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470 Mülheim/Ruhr, Germany.
Lee
W K
WK