title: Replacing oxamniquine by praziquantel against Schistosoma mansoni infection in a rural community from the sugar-cane zone of Northeast Brazil: an epidemiological follow-up.
abstract: A group of 52 villagers was followed-up for three years regarding Schistosoma mansoni infection. All villagers were periodically surveyed by the Kato-Katz method. In March 1997 and March 1998 the positives were treated with oxamniquine (15-20 mg/kg), and in March 1999, with praziquantel (60 mg/kg). All infection indices decreased substantially between March 1999 and March 2000: prevalence of infection (from 32.7% to 21.2%), prevalence of moderate/heavy infection (from 7.7% to 1.9%), intensity of infection (from 23.1 epg to 7.4 epg) and reinfection (from 35.7% to 14.3%). Negativation increased from 53.8 to 82.4. An optimistic prognostic is assumed in the short term for the introduction of praziquantel in the study area.
authors.affiliation: Laboratório de Ecologia e Controle de Moluscos Vetores, Departamento de Biologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, 21045-900, Brasil. lbeck@ioc.fiocruz.br
authors.forename: L
authors.initials: L
authors.lastname: Beck
authors.forename: T C
authors.initials: TC
authors.lastname: Favre
authors.forename: O S
authors.initials: OS
authors.lastname: Pieri
authors.forename: L C
authors.initials: LC
authors.lastname: Zani
authors.forename: G G
authors.initials: GG
authors.lastname: Domas
authors.forename: C S
authors.initials: CS
authors.lastname: Barbosa
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D018556:Crops, Agricultural; D005500:Follow-Up Studies; D006801:Humans; D010073:Oxamniquine / Q000627:therapeutic use*; D010270:Parasite Egg Count; D011223:Praziquantel / Q000627:therapeutic use*; D015995:Prevalence; D011379:Prognosis; D012008:Recurrence; D012423:Rural Health; D012550:Schistosoma mansoni / Q000302:isolation & purification; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000453:epidemiology; D012556:Schistosomicides / Q000627:therapeutic use*; D012621:Seasons
chemical_list: D000871:Anthelmintics; D012556:Schistosomicides; D010073:Oxamniquine; D011223:Praziquantel