New ammonia equivalents for the Pd-catalyzed amination of aryl halides.
[reaction: see text]. LiN(SiMe3)2, Ph3SiNH2, and LiNH2 can be be used as ammonia equivalents for the Pd-catalyzed coupling of aryl halides. Using these amine derivatives, simple anilines, including ortho-substituted ones, as well as di- and triarylamines can be readily prepared.
Huang
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Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Buchwald
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D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D000641:Ammonia / Q000737:chemistry; D000814:Aniline Compounds / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006219:Halogens / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
D000588:Amines; D000814:Aniline Compounds; D001555:Benzene Derivatives; D006219:Halogens; D010165:Palladium; D000641:Ammonia