Galectine-1 expression in cochleae of C57BL/6 mice during aging.
Presbycusis is a progressive hearing loss related to the aging process associated with auditory receptor degeneration. Adult animals exhibited galectine-1 (GAL-1) expression in epithelial cells of the inner and outer spiral sulci and Hensen cells, which was absent from the sensory and supporting cells. The progressive age-related degeneration of auditory receptor was analyzed using an anti-GAL-1 monoclonal antibody on cochleae of C57BL/6 mice (1-24 months old). Mice < or = 9 months old showed adult and healthy auditory receptors, with a similar GAL-1 expression along the time. Conversely, animals > 1 year old exhibited a sensory degeneration at the cochleae basal coil that progressively reached the middle coil. Older animals (18-24 months old) showed a single layer epithelium that replaced the auditory receptor. The age-related degenerative process of the auditory receptor involves sensory but also supporting cells, which are both substituted by epithelial non-specialized cells.
Bartolomé
M V
MV
Centre of Cell Culture (CAI-UCM),Department of Surgery II (ORL), Faculty of Medicine, Complutense University of Madrid, Apartado de Correos 60.075. 28080 Madrid, Spain.
López
L M
LM
Gil-Loyzaga
P
P
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D003051:Cochlea / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D037483:Galectin 1; D006199:Hair Cells, Auditory, Inner / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D018072:Hair Cells, Auditory, Outer / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D006309:Hearing / Q000502:physiology; D006388:Hemagglutinins / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL / Q000033:anatomy & histology / Q000378:metabolism*; D008854:Microscopy, Electron; D009410:Nerve Degeneration / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D011304:Presbycusis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology
D037483:Galectin 1; D006388:Hemagglutinins