Effect of laparoscopy on immune function.
BACKGROUND
Laparoscopic surgery is believed to lessen surgical trauma and so cause less disturbance of immune function. This may contribute to the rapid recovery noted after many laparoscopic operations. Preservation of both systemic and intraperitoneal immunity is particularly important in surgery for sepsis or cancer and so an understanding of the impact of laparoscopy on immune function is relevant.


METHODS
Literature on immunological changes following laparoscopy and open surgery was identified from Medline, along with cross-referencing from the reference lists of major articles on the subject.


CONCLUSIONS
Despite a few contradictory reports, systemic immunity appears to be better preserved after laparoscopic surgery than after open surgery. However, the local intraperitoneal immune system behaves in a particular way when exposed to carbon dioxide pneumoperitoneum; suppression of intraperitoneal cell-mediated immunity has been demonstrated in a number of studies. This feature may be clinically important and should be acknowledged when considering laparoscopic surgery in patients with malignancy or sepsis.
Gupta
A
A
University of Adelaide Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia.
Watson
D I
DI
D000210:Acute-Phase Reaction / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology; D002455:Cell Division / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007107:Immune System / Q000276:immunology*; D010535:Laparoscopy; D007962:Leukocytes / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology; D009504:Neutrophils / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines