title: Functional assessment of pancreatic parenchyma after secretin administration using serial T2-weighted echo-planar magnetic resonance imaging.
abstract: Signal intensity (SI) changes of pancreatic parenchyma were evaluated after intravenous administration of secretin using T2-weighted single-shot spin-echo echo-planar imaging (EPI) to assess this method as a magnetic resonance (MR) test of pancreatic exocrine function. Nine volunteers were studied with serial single-shot EPI of the pancreas for 15 minutes after the injection of secretin or saline. The normal pattern of pancreatic SI change was demonstrated after intravenous injection of secretin, a single peak at 3-4 minutes in the head, body, and tail, followed by a gradual decrease in SI. Saline injection did not induce a significant SI change. There was no statistical difference in the peak contrast ratios (first mean, 1.21-1.25, vs. second mean, 1.18-1.22) and peak times (first mean, 3.2-3.7 minutes, vs. second mean, 3.1-3.6) in a repeat study. By evaluating the pattern of time-response curves obtained from serial T2-weighted EPI after secretin injection, pancreatic exocrine function may be directly assessed at the level of the head, body, and tail.
authors.affiliation: Department of Radiology, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Hamamatsu, 430-8558, Japan. masui@sis.seirei.or.jp
authors.forename: T
authors.initials: T
authors.lastname: Masui
authors.forename: M
authors.initials: M
authors.lastname: Katayama
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Kabasawa
authors.forename: A
authors.initials: A
authors.lastname: Nozaki
authors.forename: H
authors.initials: H
authors.lastname: Sakahara
mesh_terms: D000328:Adult; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010179:Pancreas / Q000033:anatomy & histology*; D010186:Pancreatic Function Tests / Q000379:methods*; D015203:Reproducibility of Results; D012633:Secretin / Q000008:administration & dosage
chemical_list: D012633:Secretin