[The increasing importance of tumor and tissue banks in the light of genomic and proteomic research].
Recent technological advances in genome and proteome research offer new perspectives for diagnosis and therapy. The DNA chip technology as well as high-resolution two-dimensional gel electrophoresis in combination with mass spectrometry is able to provide comprehensive information on gene and protein expression patterns, which allow insights into the dynamic and functional aspects of diseases. The application of these techniques depends on the availability of unfixed fresh or cryopreserved tissue with short ischaemia time. For this reason tissue banks are of increasing importance. The pathologist with his expertise and responsibility for histopathological diagnosis, plays a central role in the collection of the human tissues, in accordance with medical, legal and ethical standards, not only for diagnostic purposes, but also for research. The scientific value of a tissue bank is markedly increased if tissue samples are accompanied by detailed patient data as well as blood samples. Informed consent given by the patient is an essential requirement for the use of human tissue banks in biomedical research. The informed consent should not be restricted to scientific investigations but also include the potential commercial use of the data generated.
Tschulik
A
A
Institut für Pathologie, Universität Graz, Auenbruggerplatz 25, 8036 Graz, Osterreich.
Zatloukal
K
K
D000818:Animals; D002460:Cell Line; D023281:Genomics; D006801:Humans; D020543:Proteome; D012106:Research / Q000639:trends; D012107:Research Design; D014015:Tissue Banks; D014407:Tumor Cells, Cultured
D020543:Proteome