[Effect of splenosid on lipid peroxidation process and glutathione antioxidant system in rats exposed to fractionated radiation].
The dynamics of lipid peroxidation, antioxidant glutathione system condition in blood and viscerals (brain, heart, liver, spleen) of rats which were fractionally irradiated (10 fractions) in the total dose 1.0 Gy and oxidative homeostasis increase of primary and secondary lipid peroxidation products and glutathione system disturbances were established in the irradiated rats. The administration of splenosid diminished the disturbances of oxidative homeostasis but does not completely normalize the latter. The administration of splenosid during the irradiation course and after its finishing is more effective than only during the irradiation course.
Oliĭnyk
B V
BV
Komisarenko Institute of Endocinology and Metabolism AMS of Ukraine, Kyiv.
Baraboĭ
V A
VA
Oliĭnyk
S A
SA
Horchakova
N O
NO
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001685:Biological Factors / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D005978:Glutathione / Q000378:metabolism*; D006321:Heart / Q000187:drug effects / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D009705:Nucleosides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D014020:Tissue Extracts
D000975:Antioxidants; D001685:Biological Factors; D009705:Nucleosides; D014020:Tissue Extracts; D005978:Glutathione