HLA-G: a shield against inflammatory aggression.
Recent developments in the field of HLA-G research have revealed that, besides its involvement during pregnancy, HLA-G is expressed in peripheral tissues during pathological processes, such as viral infections, malignancies and organ transplantation. Here, we discuss recent findings regarding the influence of HLA-G on the T helper (Th) cytokine balance (favoring Th2-type responses), and the expression of HLA-G during chronic, cutaneous inflammatory diseases, such as psoriasis and atopic dermatitis. We propose a novel role for HLA-G as a tissue-protective molecule in inflammatory responses.
Carosella
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Service de Recherches en Hémato-Immunologie, CEA-DSV-DRM, Hôpital Saint-Louis, Institut Universitaire d'Hématologie, 1 Avenue Claude-Vellefaux, 75010 Paris, France. carosella@dsvidf.cea.fr
Moreau
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Aractingi
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Rouas-Freiss
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N
D016207:Cytokines / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000096:biosynthesis / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000276:immunology*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome
D016207:Cytokines; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I