title: Mapping of a new autosomal dominant nonsyndromic hearing loss locus (DFNA30) to chromosome 15q25-26.
abstract: Hearing impairment is the most common inherited human sensory defect. Nonsyndromic Hearing Impairment (NSHI) is the most genetically heterogeneous trait known. Over 70 loci have been mapped and a total of 19 genes have been identified. We report here a novel locus (DFNA 30) for autosomal dominant NSHI that we mapped to chromosome 15q25-26 in an Italian four-generation family. The haplotype analysis has identified a critical interval of 18 cM between markers D15S151 and D15S130. This region does not overlap with DFNB16 locus but partially coincides with the otosclerosis (OTS) locus. Localisation of the locus DFNA30 is a first step towards the identification of the gene.
authors.affiliation: CSS Mendel Institute, IRCCS, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mangino
authors.forename: E
authors.initials: E
authors.lastname: Flex
authors.forename: F
authors.initials: F
authors.lastname: Capon
authors.forename: F
authors.initials: F
authors.lastname: Sangiuolo
authors.forename: E
authors.initials: E
authors.lastname: Carraro
authors.forename: F
authors.initials: F
authors.lastname: Gualandi
authors.forename: M
authors.initials: M
authors.lastname: Mazzoli
authors.forename: A
authors.initials: A
authors.lastname: Martini
authors.forename: G
authors.initials: G
authors.lastname: Novelli
authors.forename: B
authors.initials: B
authors.lastname: Dallapiccola
mesh_terms: D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005192:Family Health; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D008040:Genetic Linkage; D005838:Genotype; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree
chemical_list: D004247:DNA