title: 11-Demethylcyclosporins exhibit a single conformation in methanol and dimethylsulfoxide.
abstract: NMR studies showed that 11-demethylcyclosporin A (cyclosporin E) and 11-demethylcyclosporin B exist as single species both in polar and nonpolar solvents. They adopt the same conformation that was found in the solid state.
authors.affiliation: Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. sedmera@biomed.cas.cz
authors.forename: P
authors.initials: P
authors.lastname: Sedmera
authors.forename: A
authors.initials: A
authors.lastname: Jegorov
authors.forename: M
authors.initials: M
authors.lastname: Buchta
authors.forename: L
authors.initials: L
authors.lastname: Cvak
mesh_terms: D003524:Cyclosporins / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry*; D008968:Molecular Conformation; D012997:Solvents / Q000737:chemistry
chemical_list: D003524:Cyclosporins; D007166:Immunosuppressive Agents; D012997:Solvents; D000432:Methanol; D004121:Dimethyl Sulfoxide