Further analysis of prostacyclin's effect on rat gastric mucosal nucleic acid content.
Graded single and multiple oral doses of prostacyclin enhance, in a direct dose-dependent manner, the DNA and RNA content of rat gastric (antral and fundic) mucosa, resulting in a decreased RNA/DNA ratio. This latter phenomenon is a convincing sign of new cell formation. The arithmetical (theory of functions) analysis of the data resulted in equations, defined mathematically, of prostacyclin's dose-dependent effect.
Balint
G A
GA
Laboratory of Clinical Pharmacology, Department of Psychiatry, New Clinics, University of Szeged, Medical Faculty, Szeged, Hungary. balint@nepsy.szote.u-szeged.hu
D000818:Animals; D004247:DNA / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D005748:Gastric Fundus / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D011706:Pyloric Antrum / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D012313:RNA; D004247:DNA; D011464:Epoprostenol