[Analysis of apoA IV gene VNTR polymorphism in Chinese endogenous hypertriglyceridemics].
OBJECTIVE
To search the variation of apoA IV gene and its relation to endogenous hypertriglyceridemia (HTG) in Chinese population.


METHODS
Forty- seven endogenous hypertriglyceridemics and 48 healthy subjects from a population of Chinese Han nationality in Chengdu area were studied using sequencing of apoA IV gene amplified by polymerase chain reaction (PCR).


RESULTS
The frequency of (CTGT)(3) allele in Chinese control group was significantly different from that reported in German Caucasians (0.253 vs 0.607, P<0.01) and in Italian Caucasians (0.253 vs 0.522, P<0.01), but not different from that reported in Japanese (0.253 vs 0.262, P>0.05). The frequency of (CTGT)(3) allele showed no significant difference between normal control and HTG groups(0.223 vs 0.281,P>0.05). In the healthy control group, the subjects with genotype 3/3 of VNTR site had a higher serum mean concentration of LDLC as compared to those with genotype 3/4 (3.698 +/- 0.67 mmol/L vs 2.974 +/- 0.54 mmol/L, P<0.05).


CONCLUSIONS
The results suggest that VNTR polymorphism in apoA IV gene is associated with healthy control subjects to some extent in Chinese population.
Bai
H
H
Apolipoprotein Research Unit, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P.R. China. bwliu@wcums.edu.cn
Liu
R
R
Liu
Y
Y
Liu
B
B
D000328:Adult; D000368:Aged; D001054:Apolipoproteins A / Q000235:genetics*; D006801:Humans; D015228:Hypertriglyceridemia / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D011110:Polymorphism, Genetic
D001054:Apolipoproteins A; C022205:apolipoprotein A-IV