Transferring genes to salivary glands.
This review provides a brief description of gene transfer studies using salivary glands as the target tissue. The aggregate results demonstrate the potential clinical value of this methodological approach for managing several conditions lacking fully satisfactory conventional treatments. Routine clinical applications are still seven to ten years away, primarily because of the need for improved gene transfer vectors. Overall, this body of work provides the dental educator with a substantive example of how biotechnological progress will significantly affect the treatment of oral problems in the near future.
Simmons
R K
RK
Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Baum
B J
BJ
D000256:Adenoviridae / Q000235:genetics; D001709:Biotechnology; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects; D012469:Salivary Glands / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000235:genetics; D012859:Sjogren's Syndrome / Q000628:therapy; D014987:Xerostomia / Q000209:etiology / Q000628:therapy
D012471:Salivary Proteins and Peptides