title: Transposition of the great arteries associated with ventricular septal defect: surgical results and long-term outcome.
abstract: OBJECTIVE
  To identify potential risk factors influencing early and late outcome following the arterial switch operation (ASO) for transposition of the great arteries associated with ventricular septal defect including double-outlet right or left ventricle.
  
  
  METHODS
  All patients who underwent ASO in our department until August 2000 (n=105) were included in this study. There were 77 transpositions of the great arteries with ventricular septal defect, 22 Taussig-Bing hearts and six patients with double-outlet morphology. The median age at operation was 24 days. Aortic arch obstruction was present in 25 patients; in 13 of these patients, a repair with aortic arch reconstruction was done before ASO. The usual coronary artery pattern was present in 59% of the patients. In six patients, we found an intramural course of at least one coronary artery. The ventricular septal defect was closed with a patch through the right atrium (n=35), the aorta (n=25), the pulmonary artery (n=25) or the right ventricle (n=3); in 17 patients a combined approach was necessary.
  
  
  RESULTS
  There were five hospital deaths (4.7%, 95% confidence limit 2-11%). The median duration of follow-up was 72 months. Fourteen patients underwent 15 reoperations 33 months after repair (median), eight for right ventricular outflow tract obstruction or neopulmonary stenosis. Four late deaths occurred, two due to complications related to coronary artery anomalies. Statistical analysis revealed no significant risk factor whatsoever correlating with death or need for reoperation. Survival after 12 years was 91.6%, and freedom from reoperation was 82.6%. Latest follow-up data showed that 13% of patients were in NYHA class II and/or required medical treatment; 87% were in NYHA class I.
  
  
  CONCLUSIONS
  ASO associated with patch closure of ventricular septal defect can be performed early in life with a low risk of mortality (<5%), low incidence of reintervention (<15%) and promising long-term outcome.
authors.affiliation: Department of Pediatric Cardiac Surgery, Deutsches Kinderherzzentrum, 53757 Sankt Augustin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Wetter
authors.forename: E
authors.initials: E
authors.lastname: Belli
authors.forename: N
authors.initials: N
authors.lastname: Sinzobahamvya
authors.forename: H C
authors.initials: HC
authors.lastname: Blaschzok
authors.forename: A M
authors.initials: AM
authors.lastname: Brecher
authors.forename: A E
authors.initials: AE
authors.lastname: Urban
mesh_terms: D001017:Aortic Coarctation / Q000401:mortality / Q000601:surgery; D003330:Coronary Vessel Anomalies / Q000401:mortality / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006345:Heart Septal Defects, Ventricular / Q000401:mortality / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications / Q000401:mortality / Q000601:surgery*; D012086:Reoperation; D015996:Survival Rate; D014188:Transposition of Great Vessels / Q000401:mortality / Q000601:surgery*