Effect of dietary seal and fish oils on lipid metabolism in hamsters.
Eicosapentaenoic and docosahexaenoic acids were distributed mainly in the sn-1 and 3 positions of seal oil triacylglycerols and in the sn-2 position of fish oil triacylglycerols. Seal oil-rich or fish oil-rich fats having constant polyunsaturated (PUFAs)/monounsaturated/saturated fatty acids and n-6/n-3 PUFAs ratios were fed to hamsters for 3 weeks. The control fat contained linoleic acid as the sole PUFA. The concentration of triacylglycerols in the liver was significantly lower in the fish oil group than in the control group. Phospholipid concentration in serum was lower and that in the liver was higher in the seal oil group compared with the fish oil group. The activities of fatty acid synthase (FAS), glucose-6-phosphate dehydrogenase (G6PDH), and the malic enzyme were significantly lower in both the fish and seal oil groups than in the control group. Dietary seal oil more effectively reduced arachidonic acid content in liver phosphatidylcholine and phosphatidylethanolamine and serum phosphatidylcholine than fish oil. These results showed that different intramolecular distribution of n-3 PUFAs influenced glycerolipid metabolism and arachidonic acid content in serum and liver phospholipids of hamsters.
Yoshida
H
H
Division of Food and Nutrition, Nakamura Gakuen Junior College, Fukuoka, Japan.
Ikeda
I
I
Tomooka
M
M
Mawatari
M
M
Imaizumi
K
K
Seto
A
A
Tsuji
H
H
D000818:Animals; D006224:Cricetinae; D004281:Docosahexaenoic Acids / Q000008:administration & dosage* / Q000378:metabolism; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage* / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000378:metabolism; D005395:Fish Oils / Q000008:administration & dosage / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D010743:Phospholipids / Q000097:blood; D046048:Seals, Earless; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
D005395:Fish Oils; D010743:Phospholipids; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D005954:Glucosephosphate Dehydrogenase; D064429:Fatty Acid Synthases