Cerebrospinal fluid penetration of levofloxacin in patients with spontaneous acute bacterial meningitis.
We have assessed levofloxacin penetration in cerebrospinal fluid (CSF) and the liquor-to-plasma ratio (C(L)/C(P)) at 2 hours after dosing in 5 patients with spontaneous acute bacterial meningitis. CSF levofloxacin concentration at 2 hours after dosing was 1.99+/-0.67 microg/mL, and the C(L)/C(P) at 2 hours after dosing was 0.34+/-0.09.
Scotton
P G
PG
Department of Infectious Diseases, Regional Hospital Cà Foncello, Treviso, Italy. pscotton@ulss.tv.it
Pea
F
F
Giobbia
M
M
Baraldo
M
M
Vaglia
A
A
Furlanut
M
M
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008297:Male; D020814:Meningitis, Escherichia coli / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008585:Meningitis, Meningococcal / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008875:Middle Aged; D015242:Ofloxacin / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics / Q000627:therapeutic use
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin