Benign idiopathic partial seizures in the velocardiofacial syndrome: report of two cases.
We describe two children with the velocardiofacial syndrome and benign partial-onset seizures. Both presented with slight dysmorphic traits, mild to moderate mental delay, and high-arched palate. A cardiac defect was present in only one of them. In each patient, sporadic rolandic or occipital partial-onset seizures with the clinical and electroencephalographic features of benign idiopathic childhood epilepsy manifested at age 3 and 5 years, respectively. Treatment was started only in one patient, with complete seizure control. These two cases show that benign partial epilepsy can be a component manifestation of the central nervous system-related symptoms of the velocardiofacial syndrome.
Coppola
G
G
Department of Pediatrics /Clinic of Child Neuropsychiatry, Second University of Naples, Via Pansini 5, 80131 Naples, Italy.
Sciscio
N
N
Russo
F
F
Caliendo
G
G
Pascotto
A
A
D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology*; D002648:Child; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D002972:Cleft Palate / Q000473:pathology*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000473:pathology*; D005145:Face / Q000002:abnormalities*; D006330:Heart Defects, Congenital / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D013577:Syndrome