Using SHIVs to develop an anti-HIV-1 live-attenuated vaccine.
The use of chimeric simian and human immunodeficiency viruses (SHIVs) that encode HIV-1 Env and are infectious to macaques has made it possible to analyze the pathogenicity of HIV-1 in vivo, and to evaluate the efficacy of candidate vaccines in macaques. In addition, we believe that gene-deleted SHIVs could potentially be used as anti-HIV-1 live-attenuated vaccines. Gene-deleted SHIVs replicate transiently, are non-pathogenic and induce strong protection against challenge infection. The most important advantage of gene-deleted SHIVs is that their efficacy and safety can be evaluated in macaques before they are used in humans.
Kuwata
T
T
Institute for Virus Research, Kyoto University, Shogoin-Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Miura
T
T
Hayami
M
M
D016915:AIDS Vaccines / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D017353:Gene Deletion; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D016896:Treatment Outcome; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
D016915:AIDS Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic