Medical treatment of canine pituitary-dependent hyperadrenocorticism (Cushing's disease).
Pituitary-dependent hyperadrenocorticism (Cushing's disease) is a relatively common endocrine disorder of middle- to old-age dogs. Three treatments commonly used in the management of pituitary-dependent Cushing's disease in dogs include mitotane, ketoconazole, and L-deprenyl. These medications are associated with the potential of different side effects and expense, but all can produce satisfactory results in dogs with this disease. The choice of treatment for a given dog depends on the severity of the dog's disease, as well as clinician and client preferences. This article reviews the indications and adverse effects associated with each of these three drugs, as well as the treatment protocols commonly used in treating dogs with hyperadrenocorticism.
Peterson
M E
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Division of Endocrinology, Bobst Hospital, Caspary Research Institute, Animal Medical Center, New York, New York, USA.
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D003480:Cushing Syndrome / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007654:Ketoconazole / Q000009:adverse effects / Q000627:therapeutic use; D008939:Mitotane / Q000009:adverse effects / Q000627:therapeutic use*; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D010900:Pituitary Diseases / Q000188:drug therapy / Q000662:veterinary*; D010902:Pituitary Gland / Q000473:pathology; D012642:Selegiline / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
D000935:Antifungal Agents; D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D008939:Mitotane; D007654:Ketoconazole