[The synthesis and pharmacological activities of C-galactosides of furanosequiterpenes].
Four new C-galactosides were obtained by treatment of 1-O-trifluoroacetly-2, 3, 4, 6-tetra-O-benzly-alpha-D-galactopranose with 7-methoxy-6-(3-pentenyl)-3, 5-dimethylbenzofuran, 7-acetoxy-6-(3-pentenyl)-3, 5-dimethylbenzofuran and 1, 2-dihydrocacalohastin in the presence of Lewis acid. Their structures and compositions were elucidated by elemental analysis and spectroscopic methods. The results of the pharmacological test indicated that the sesquiterpenes are calcium antagonist but their C-galactosides are calcium agonist.
Chen
H M
HM
School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083
Wang
Y Y
YY
Mao
J M
JM
Cai
M S
MS
Jia
Z J
ZJ
D002118:Calcium / Q000819:agonists*; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides; D009005:Monosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
C438934:C-glycoside; D002121:Calcium Channel Blockers; D006027:Glycosides; D009005:Monosaccharides; D012717:Sesquiterpenes; D002118:Calcium