title: (1)H-MR spectroscopy is sensitive to subtle effects of perinatal asphyxia.
abstract: The authors performed neuropsychological and (1)H-MRS studies in 18 subclinical patients with antecedents of perinatal asphyxia (PA) and in 18 matched control subjects. Patients with PA showed reduced values of N-acetylaspartate (NAA) in both the basal ganglia and the midtemporal region (MTR) and reduced NAA/choline values in the MTR. Neuropsychological testing showed group differences in tasks related to attention and memory. These results indicate persistent dysfunctions in cerebral structures vulnerable to hypoxia and demonstrate the utility of MRS for the long-term evaluation of cerebral sequelae of neonatal asphyxia.
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain.
authors.forename: C
authors.initials: C
authors.lastname: Mañeru
authors.forename: C
authors.initials: C
authors.lastname: Junqué
authors.forename: N
authors.initials: N
authors.lastname: Bargalló
authors.forename: M
authors.initials: M
authors.lastname: Olondo
authors.forename: F
authors.initials: F
authors.lastname: Botet
authors.forename: M
authors.initials: M
authors.lastname: Tallada
authors.forename: J
authors.initials: J
authors.lastname: Guardia
authors.forename: J M
authors.initials: JM
authors.lastname: Mercader
mesh_terms: D000293:Adolescent; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D001238:Asphyxia Neonatorum / Q000175:diagnosis* / Q000503:physiopathology; D001479:Basal Ganglia / Q000503:physiopathology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000503:physiopathology; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D002794:Choline / Q000378:metabolism*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013702:Temporal Lobe / Q000503:physiopathology
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D002794:Choline