title: Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis.
abstract: BACKGROUND
  There are already many effective topical therapies available for use in the treatment of chronic plaque psoriasis. Unfortunately, these treatments are often associated with a rather significant risk of undesirable effects.
  
  
  OBJECTIVE
  In this randomized, prospective clinical trial, the effects of the vitamin D(3) analog calcipotriol were evaluated against those of a recently developed vitamin B(12) cream containing avocado oil in an intraindividual right/left-side comparison. The trial population consisted of 13 patients, 10 men and 3 women, with chronic plaque psoriasis. The observation period was 12 weeks; the effects of therapy were assessed on the basis of a PASI score adapted to the right/left-side comparison technique, the subjective evaluations of the investigator and patients and the results of 20-MHz sonography.
  
  
  RESULTS
  There was a more rapid development of beneficial effects with the use of calcipotriol in the initial 8 weeks, although differences in effects were significant only at the time point of therapy week 8 (p < 0.05). After 12 weeks, neither the PASI score nor 20-MHz sonography showed significant differences between the two treatments. While the efficacy of the calcipotriol preparation reached a maximum in the first 4 weeks and then began to subside, the effects of the vitamin B(12) cream containing avocado oil remained at a constant level over the whole observation period. This would indicate that the vitamin B(12) preparation containing avocado oil may be suitable for use in long-term therapy, a hypothesis further supported by the fact that the investigator and the patients assessed the tolerability of the vitamin B(12) cream containing avocado oil as significantly better in comparison with that of calcipotriol.
  
  
  CONCLUSIONS
  The results of this clinical trial provide evidence that the recently developed vitamin B(12) cream containing avocado oil has considerable potential as a well-tolerated, long-term topical therapy of psoriasis.
authors.affiliation: Department of Dermatology and Allergology, Ruhr University, Bochum, Germany. M.Struecker@derma.de
authors.forename: M
authors.initials: M
authors.lastname: Stücker
authors.forename: U
authors.initials: U
authors.lastname: Memmel
authors.forename: M
authors.initials: M
authors.lastname: Hoffmann
authors.forename: J
authors.initials: J
authors.lastname: Hartung
authors.forename: P
authors.initials: P
authors.lastname: Altmeyer
mesh_terms: D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D027421:Persea; D008517:Phytotherapy; D010938:Plant Oils / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D011537:Pruritus / Q000139:chemically induced; D011565:Psoriasis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography; D014805:Vitamin B 12 / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D003879:Dermatologic Agents; D009824:Ointments; D010938:Plant Oils; C055085:calcipotriene; D002117:Calcitriol; D014805:Vitamin B 12