A report of a rare immediate reaction after ingestion of acetaminophen.
BACKGROUND
Acetaminophen hypersensitivity is rare and, when seen, is usually in association with sensitivity to nonsteroidal anti-inflammatory drugs.


METHODS
This is a case report of an immediate reaction to acetaminophen, confirmed by a drug challenge, in a subject who tolerated ibuprofen.


RESULTS
After an oral challenge with 50 mg of acetaminophen, the subject had generalized pruritus, urticaria, and dyspnea.


CONCLUSIONS
This patient demonstrates a rare but potentially severe reaction to acetaminophen that may occur in patients who are not otherwise sensitive to other nonsteroidal anti-inflammatory drugs.
Grant
J A
JA
University of Iowa, Iowa City 52242, USA.
Weiler
J M
JM
D000082:Acetaminophen / Q000009:adverse effects*; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen