Primary degenerative mild cognitive impairment: study population, clinical, brain imaging and biochemical findings.
Mild cognitive impairment (MCI) is a heterogeneous clinical syndrome for which no international diagnostic criteria have yet been established. Longitudinal studies have shown that many individuals who later develop dementia pass through a stage of MCI. We are following up 36 individuals who were initially diagnosed as having the memory-impaired primary degenerative type of MCI and therefore are at high risk of developing Alzheimer's disease. Clinical, neuropsychological, brain imaging and CSF biochemical markers were examined. Findings were remarkably heterogeneous even in this highly selected group of patients. This suggests that MCI is aetiologically not uniform.
Lautenschlager
N T
NT
Department of Psychiatry and Psychotherapy, Technische Universität München, Moehlstrasse 26, D-81675 Munich, Germany.
Riemenschneider
M
M
Drzezga
A
A
Kurz
A F
AF
D000368:Aged; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003704:Dementia / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D013577:Syndrome; D014055:Tomography, Emission-Computed
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015415:Biomarkers