Pathomorphological and biosynthetic changes in gastric epithelium during chronic duodenal ulcer.
We studied structural changes and biosynthetic processes in the gastric epithelium in patients with chronic duodenal ulcer. The severity of alterative ultrastructural changes in surface epithelial and glandular cells progressively increased from proximal to distal portion of the stomach. Biosynthesis of nucleic acids within the epithelium depended on the morphofunctional state of epitheliocytes. DNA biosynthesis in the fundus was less intensive. The intensity of RNA synthesis did not differ between various gastric regions. Our results suggest that structural and metabolic dimorphism of the fundic and pyloric epithelium underlies pathological changes in the mucosa during ulcer disease.
Lapii
G A
GA
Laboratory of Ultrastructural Bases of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. pathol@cyber.nsk.ma.ru
Abramova
E E
EE
Nepomnyashchikh
D L
DL
D000293:Adolescent; D000328:Adult; D000368:Aged; D001345:Autoradiography; D001706:Biopsy; D002908:Chronic Disease; D004247:DNA / Q000096:biosynthesis*; D004381:Duodenal Ulcer / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012313:RNA / Q000096:biosynthesis*
D012313:RNA; D004247:DNA