Use of 2-(tert-butyldiphenylsilyloxymethyl) benzoyl as N-protecting group for the synthesis of prooligonucleotides.
A short TCCT Me-SATE prooligonucleotide was successfully synthesized using 2-(tert-butyldiphenyloxymethyl) benzoyl protecting group, after its removal by means of trimethylsilyl chloride and water.
Guerlavais
T
T
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, Université de Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5, France.
Meyer
A
A
Imbach
J L
JL
Morvan
F
F
D002851:Chromatography, High Pressure Liquid; D009841:Oligonucleotides / Q000138:chemical synthesis*; D012833:Siloxanes / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014297:Trimethylsilyl Compounds / Q000737:chemistry
C442900:2-(tert-butyldiphenylsilyloxymethyl)benzoyl; D009841:Oligonucleotides; D012833:Siloxanes; D014297:Trimethylsilyl Compounds