title: Esophageal dysmotility in an adult with chronic granulomatous disease.
abstract: Chronic granulomatous disease (CGD) is a group of hereditary disorders of impaired intracellular destruction of phagocytosed bacteria. Gastrointestinal manifestations are present, with hepatic abscess being the most common. In this case report, we present an adult with CGD with esophageal involvement, which has been described in only one other adult. The clinical history, modalities of diagnosis (including endoscopy, barium radiography, and esophageal manometry), and therapeutic strategies pertaining to the esophageal manifestations of CGD are discussed. A review of the pertinent available literature is provided.
authors.affiliation: Division of Gastroenterology Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: M
authors.initials: M
authors.lastname: Golioto
authors.forename: J B
authors.initials: JB
authors.lastname: O'Connor
mesh_terms: D000328:Adult; D003680:Deglutition Disorders / Q000175:diagnosis / Q000209:etiology; D019160:Endosonography / Q000379:methods; D015154:Esophageal Motility Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D004945:Esophagoscopy / Q000379:methods; D005500:Follow-Up Studies; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008365:Manometry; D011241:Prednisone / Q000008:administration & dosage*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D011241:Prednisone