title: A new insight into mechanisms of age-related changes in heart rate.
abstract: Changes in cardiac rhythm induced by blockade of hyperpolarization currents with ZD 7288 depend on animal's age. The increase in cardiointerval duration is related to prolongation of T-P segment on ECG. It is hypothesized that the age-related changes in activity of hyperpolarization channels are determined by a modulating effect of the autonomic nervous system.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan State Pedagogical University.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
authors.forename: N V
authors.initials: NV
authors.lastname: Svyatova
authors.forename: N I
authors.initials: NI
authors.lastname: Ziyatdinova
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats
chemical_list: D002316:Cardiotonic Agents; D007473:Ion Channels; D011743:Pyrimidines; C082246:ICI D2788