[18F] labeled diacylglycerol analogue as a potential agent to trace myocardial phosphoinositide metabolism.
Phosphoinositide metabolism plays an important role in cardiac pathophysiology. To investigate whether [18F]diacylglycerol could be used to trace myocardial phosphoinositide metabolism, lipids were extracted from rat myocardium after the injection. 1-[8-[18F]fluorooctanoyl]-2-palmitoylglycerol and 1-[8-[18F]fluoropalmitoyl]-2-palmitoylglycerol were predominantly metabolized to phosphatidylethanolamine and triacylglycerol, respectively. The radioactivity incorporated into phosphoinositide metabolism was 51, 44, 32, and 30% 3, 5, 10, and 30 minutes after the injection of 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol, respectively. 1-[4-[18F]fluorobutyryl]-2-palmitoylglycerol might be a potential tracer to evaluate myocardial phosphoinositide metabolism early after the injection.
Chida
M
M
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kagaya
Y
Y
Nagata
S
S
Mukoyoshi
M
M
Namiuchi
S
S
Yamane
Y
Y
Ishide
N
N
Watanabe
J
J
Takahashi
T
T
Ido
T
T
Shirato
K
K
D000818:Animals; D002855:Chromatography, Thin Layer; D005462:Fluorine Radioisotopes; D005990:Glycerol / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D019275:Radiopharmaceuticals / Q000097:blood / Q000138:chemical synthesis; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D005462:Fluorine Radioisotopes; D010716:Phosphatidylinositols; D019275:Radiopharmaceuticals; D005990:Glycerol