title: Development. Endothelium--chicken soup for the endoderm.
abstract: Endothelial cells in blood vessels are known to be important during the later stages of organ development in the embryo. However, their involvement at the induction stage of organ formation has not been previously documented. As Bahary and Zon explain in their Perspective, new work demonstrates that endothelial cells secrete factors early in development that induce embryonic endoderm to become liver or pancreas (Matsumoto et al., Lammert et al.).
authors.affiliation: Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: N
authors.initials: N
authors.lastname: Bahary
authors.forename: L I
authors.initials: LI
authors.lastname: Zon
mesh_terms: D000818:Animals; D001011:Aorta / Q000196:embryology / Q000502:physiology; D051792:Basic Helix-Loop-Helix Proteins; D002454:Cell Differentiation; D046508:Culture Techniques; D004627:Embryonic Induction; D004707:Endoderm / Q000502:physiology*; D016228:Endothelial Growth Factors / Q000235:genetics; D004730:Endothelium, Vascular / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D005136:Eye Proteins; D018507:Gene Expression Regulation, Developmental; D017228:Hepatocyte Growth Factor / Q000502:physiology; D022781:Hepatocytes / Q000166:cytology; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D007328:Insulin / Q000096:biosynthesis / Q000235:genetics; D007515:Islets of Langerhans / Q000098:blood supply / Q000166:cytology / Q000196:embryology*; D007668:Kidney / Q000196:embryology; D008099:Liver / Q000166:cytology / Q000196:embryology*; D008222:Lymphokines / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D008934:Mitogens / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D010179:Pancreas / Q000098:blood supply / Q000166:cytology / Q000196:embryology*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology; D040262:Receptors, Vascular Endothelial Growth Factor; D012097:Repressor Proteins; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived; D042442:Vascular Endothelial Growth Factors; D014981:Xenopus
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D016228:Endothelial Growth Factors; D005136:Eye Proteins; D017228:Hepatocyte Growth Factor; D018398:Homeodomain Proteins; D007328:Insulin; D008222:Lymphokines; D008934:Mitogens; D009419:Nerve Tissue Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D020794:Receptor Protein-Tyrosine Kinases; D017978:Receptors, Growth Factor; D040262:Receptors, Vascular Endothelial Growth Factor; D012097:Repressor Proteins; D015534:Trans-Activators; D042461:Vascular Endothelial Growth Factor A; D042662:Vascular Endothelial Growth Factor, Endocrine-Gland-Derived; D042442:Vascular Endothelial Growth Factors; C000605732:Pax6 protein, mouse; C084010:pancreatic and duodenal homeobox 1 protein; C093564:Neurogenic differentiation factor 1