Role of activity of gastrointestinal microflora in absorption of calcium and magnesium in rats fed beta1-4 linked galactooligosaccharides.
Rats fed a diet containing beta1-4 linked galactooligosaccharides (GOS) (5 g/100 g of diet) absorbed calcium and magnesium more efficiently than those fed the control diet. However, the increment obtained through GOS-feeding was reduced by neomycin sulfate (0.67 g/100 g of diet). Since the decrease in cecal pH in rats fed GOS was suppressed by neomycin-feeding, bacterial action in the digestive tract was considered to be reduced by neomycin-feeding. Our findings suggest that the action of intestinal bacteria is necessary for the effects of GOS.
Chonan
O
O
Yakult Central Institute for Microbiological Research, Tokyo, Japan. osamu-chonan@yakult.co.jp
Takahashi
R
R
Watanuki
M
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002118:Calcium / Q000493:pharmacokinetics*; D002432:Cecum / Q000187:drug effects; D004032:Diet; D004064:Digestive System / Q000378:metabolism / Q000382:microbiology*; D005243:Feces / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000502:physiology*; D008274:Magnesium / Q000493:pharmacokinetics*; D008297:Male; D009355:Neomycin / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D014312:Trisaccharides / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D014312:Trisaccharides; C072242:4'-galactooligosaccharide; D009355:Neomycin; D008274:Magnesium; D002118:Calcium