title: The nature of the association between diet and serum lipids in the community: a twin study.
abstract: Diet is commonly thought to be an environmental influence on serum lipid concentrations. This study evaluated whether total caloric and fat intake predict total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TRIG) concentrations for environmental, as compared with genetic, reasons among 137 monozygotic and 67 dizygotic young adult twins. When genetic influences were controlled by correlating differences between monozygotic co-twins, a significant association remained between diet and TC, LDL, and HDL, suggesting that these dietary and serum lipid measures correlate for environmental reasons. Twin structural equation modeling confirmed these results. Overall, these results provide additional support for the hypothesis that diet is an environmental influence on TC, LDL, and HDL.
authors.affiliation: Department of Psychology, University of Pittsburgh, Pennsylvania 15260, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: McCaffery
authors.forename: M F
authors.initials: MF
authors.lastname: Poque-Geile
authors.forename: M F
authors.initials: MF
authors.lastname: Muldoon
authors.forename: T T
authors.initials: TT
authors.lastname: Debski
authors.forename: R R
authors.initials: RR
authors.lastname: Wing
authors.forename: S B
authors.initials: SB
authors.lastname: Manuck
mesh_terms: D000293:Adolescent; D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D012307:Risk Factors; D012931:Social Environment; D014280:Triglycerides / Q000097:blood; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol