title: Intracanal use of a corticosteroid-antibiotic compound for the management of posttreatment endodontic pain.
abstract: OBJECTIVE
  The purpose of this randomized, double-blind study was to determine the effect of a corticosteroid-antibiotic combination when used as an intracanal medicament for the treatment of posttreatment pain in endodontically involved teeth with vital pulp-test readings.
  
  
  METHODS
  Out of 988 patients, 480 experienced intratreatment pain. Endodontic treatment was completed in 3 visits. Patients who experienced pain after the first or second visit (postextirpation or postinstrumentation) were given an emergency visit during which no local anesthetic was used. The patients randomly received either intracanal corticosteroid-antibiotic compound or a placebo. Patients subjectively rated their pain on a scale of 1 to 4 as none, mild, moderate, and severe. The ratings were done at 1, 2, 4, 8, 12, and 24 hours postmedication.
  
  
  RESULTS
  Intracanal use of the corticosteroid-antibiotic medication significantly reduced (P < .001) the mean pain score quite rapidly and was significantly superior to the placebo until the end of the study (P < .001). Furthermore, there were no reoccurrences of pain, and no side effects from use of the drug were noted.
  
  
  CONCLUSIONS
  These results support the intracanal use of corticosteroid-antibiotic combination for controlling posttreatment endodontic pain.
authors.affiliation: Department of Endodontics, Faculty of Oral and Dental Medicine, Cairo University, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Negm
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006096:Gramicidin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000627:therapeutic use*; D009761:Nystatin / Q000627:therapeutic use*; D012388:Root Canal Irrigants / Q000627:therapeutic use*; D012390:Root Canal Therapy / Q000009:adverse effects; D014098:Toothache / Q000188:drug therapy* / Q000209:etiology; D014222:Triamcinolone Acetonide / Q000627:therapeutic use*
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; C014118:Gramicidin, Neomycin Sulfate, Nystatin, Triamcinolone Acetonide Drug Combination; D012388:Root Canal Irrigants; D009761:Nystatin; D006096:Gramicidin; D014222:Triamcinolone Acetonide; D009355:Neomycin