[Experimental study of dahuang zhechong pills in the treatment of immunological liver fibrosis in rats].
OBJECTIVE
To study the effect of DHZC on liver fibrosis.


METHODS
Immuno-injured fibrosis in rats was induced by bovine serum albumin and DHZC was given during and after the model production respectively. Hepatic collagen contents, pathology of liver and serum hyaluronic acid were measured. Colchicine was used as control.


RESULTS
It shows that the liver fibrosis rates of the DHZC treated group during and after the model production were 72.7% and 71.2% respectively, while those of the untreated and colchicine group were 92.3%-100%. Compared with the untreated group, there was a remarkable decrease of hepatic collagen contents in the DHZC-treated rats.


CONCLUSIONS
DHZC have thus been proved helpful in reversing liver fibrosis to some extent.
Sun
K
K
The First Affiliated Hospital, Hunan Medical College of TCM, Changsha 410007.
Chen
X
X
Liu
W
W
Chen
N
N
Chu
Y
Y
Xie
F
F
D000818:Animals; D003094:Collagen; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006820:Hyaluronic Acid / Q000097:blood; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012250:Rheum / Q000737:chemistry*; D012710:Serum Albumin, Bovine
D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D012710:Serum Albumin, Bovine; D006820:Hyaluronic Acid; D003094:Collagen; D006909:Hydroxyproline