Influence of preeclampsia or maternal intake of omega-3 fatty acids on the vasoactive effect of prostaglandin F-two-alpha in human umbilical arteries.
The vasoactive effect of prostaglandin F(2alpha) (PGF(2alpha)) was studied in in vitro perfused human umbilical arteries following maternal dietary supplementation with omega-3 fatty acids or in pregnancies complicated by a moderate degree of preeclampsia. In most preparations PGF(2alpha) induced a biphasic pressure response with a transient dilatation followed by a constrictory response. The pressure increase was significant in both groups, but no significant differences in the constrictory response or in the proportions of preparations displaying dilatatory responses were observed when compared to appropriate control groups. In conclusion, neither preeclampsia nor dietary supplementation with cod-liver oil had any significant effect on the vasoactive response to PGF(2alpha) in umbilical cord arteries.
Haugen
G
G
Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway. guttorm.haugen@rikshospitalet.no
Helland
I
I
D000704:Analysis of Variance; D003060:Cod Liver Oil / Q000627:therapeutic use; D003314:Corn Oil / Q000627:therapeutic use; D019587:Dietary Supplements; D015237:Dinoprost / Q000502:physiology*; D015525:Fatty Acids, Omega-3 / Q000502:physiology* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D011225:Pre-Eclampsia / Q000178:diet therapy* / Q000503:physiopathology*; D011247:Pregnancy; D012701:Serotonin / Q000502:physiology; D014469:Umbilical Arteries / Q000503:physiopathology*; D014655:Vascular Resistance / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology*
D015525:Fatty Acids, Omega-3; D012701:Serotonin; D003314:Corn Oil; D003060:Cod Liver Oil; D015237:Dinoprost