Enzymatic characterization of TEM-63, a TEM-type extended spectrum beta-lactamase expressed in three different genera of Enterobacteriaceae from South Africa.
The extended-spectrum beta-lactamase, TEM-63, was identified in three separate genera of South African isolates: Proteus mirabilis, Klebsiella pneumoniae, and Escherichia coli. This paper describes identification of the gene in these isolates and compares relative rates of hyrolysis between TEM-63 and other known ceftazidimases.
Hanson
N D
ND
Center for Research in Anti-Infectives and Biotechnology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA. ndhanson@creighton.edu
Smith Moland
E
E
Pitout
J D
JD
D019943:Amino Acid Substitution; D003001:Cloning, Molecular; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000235:genetics*; D007711:Klebsiella pneumoniae / Q000201:enzymology*; D011513:Proteus mirabilis / Q000201:enzymology*; D013019:South Africa; D001618:beta-Lactamases / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
C440929:beta-lactamase TEM-63; D001618:beta-Lactamases