RNA interference: it's a small RNA world.
Short RNAs regulate gene expression in many species. Some are generated from any double-stranded RNA and degrade complementary RNAs; others are encoded by genes and repress specific mRNAs. Both, it turns out, are processed and handled by similar proteins. These pathways offer a glimpse into a world of small RNAs.
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Cell and Developmental Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
D000818:Animals; D029681:Arabidopsis Proteins; D060565:Argonaute Proteins; D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D020868:Gene Silencing; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D010940:Plant Proteins / Q000235:genetics / Q000502:physiology; D012323:RNA Processing, Post-Transcriptional; D012330:RNA, Double-Stranded / Q000378:metabolism*; D034741:RNA, Small Interfering; D022661:RNA, Untranslated / Q000378:metabolism*; D034743:RNA-Induced Silencing Complex
C117457:AGO1 protein, Arabidopsis; C433807:AGO2 protein, Drosophila; D029681:Arabidopsis Proteins; D060565:Argonaute Proteins; D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D015801:Helminth Proteins; D019476:Insect Proteins; D010940:Plant Proteins; D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering; D022661:RNA, Untranslated; D034743:RNA-Induced Silencing Complex; C122185:rde-1 protein, C elegans