title: A new type of tyrosinase inhibitors from natural products as potential treatments for hyperpigmentation.
abstract: Selected flavonoids were evaluated for their effects on melanin biosynthesis by using mushroom-tyrosinase assay. Out of 27 tested flavonoids, only six showed a potential inhibitory activity on melanin biosynthesis. Flavonoids containing an alpha-keto group showed to be the active compounds in this assay. This may be explained in terms of similarity between the dihydroxyphenyl group in L-DOPA and the alpha-ketol group in flavonoids. The results of this study revealed a new type of tyrosinase inhibitor from natural origin. These compounds will be further examined for their application for treatment of hyperpigmentation problems e.g. melasma and ephelides.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy Mansoura University, Egypt.
authors.forename: F A
authors.initials: FA
authors.lastname: Badria
authors.forename: M A
authors.initials: MA
authors.lastname: elGayyar
mesh_terms: D000872:Anthocyanins; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005415:Flavins / Q000627:therapeutic use*; D005419:Flavonoids / Q000627:therapeutic use*; D017495:Hyperpigmentation / Q000188:drug therapy*; D007529:Isoflavones / Q000627:therapeutic use*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*
chemical_list: D000872:Anthocyanins; D004791:Enzyme Inhibitors; D005415:Flavins; D005419:Flavonoids; D007529:Isoflavones; D014442:Monophenol Monooxygenase