title: Diffusion-weighted magnetic resonance in cerebral venous thrombosis.
abstract: BACKGROUND
  Cerebral venous thrombosis (CVT) is a cause of stroke with obscure pathophysiologic properties that differ from arterial stroke. Its main mechanisms of pathophysiology are the breakdown of the blood-brain barrier and the coexistence of cytotoxic and vasogenic edema. However, conventional magnetic resonance imaging (MRI) cannot differentiate between vasogenic and cytotoxic edema.
  
  
  OBJECTIVE
  To describe the diffusion-weighted imaging (DWI) findings and characterize the clinical applications of DWI in CVT.
  
  
  METHODS
  A tertiary referral center, neurology department.
  
  
  METHODS
  From November 1998 to March 2001, 14 patients (5 men, 9 women; mean age, 43 +/- 10 years) with CVT underwent DWI, conventional MRI, MR venography, or conventional cerebral angiography. Abnormal findings on DWI and conventional MRI indicated the necessity of MR venography and conventional angiography to confirm the diagnosis of CVT. Apparent diffusion coefficient (ADC) values were measured in all of the abnormal lesions with visual inspection of DWI and T2-weighted echo planar imaging.
  
  
  RESULTS
  Findings on DWI were grouped according to 3 patterns: (1) Heterogeneous signal intensity (SI) (10 patients) showed mixed bright high SI and low SI and the corresponding ADC values were inversely correlated to the DWI SI. The areas of prominent low SI on DWI were reversed with adequate treatment on follow-up MRI in 1 patient. (2) Multifocal high SI (3 patients) was similar to that observed in acute arterial stroke. The corresponding ADC values were decreased and DWI was performed in the acute stages. (3) Intravascular clot with high SI was found with (1 patient, also in heterogeneous SI group) or without (1 patient) parenchymal lesions. In 1 patient, DWI demonstrated T2-negative and fluid attenuated inversion recovery-negative lesions without correlative symptoms.
  
  
  CONCLUSIONS
  These data suggest that DWI with ADC maps can be used to discriminate between types of edema for tissue viability and to provide information about stages and diagnostic clues in CVT.
authors.affiliation: Department of Neurology and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
authors.forename: K
authors.initials: K
authors.lastname: Chu
authors.forename: D W
authors.initials: DW
authors.lastname: Kang
authors.forename: B W
authors.initials: BW
authors.lastname: Yoon
authors.forename: J K
authors.initials: JK
authors.lastname: Roh
mesh_terms: D000208:Acute Disease; D000328:Adult; D002533:Cerebral Angiography; D003221:Confusion / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010211:Papilledema / Q000209:etiology; D010291:Paresis / Q000209:etiology; D012640:Seizures / Q000209:etiology; D020521:Stroke / Q000175:diagnosis / Q000503:physiopathology