Fetoscopic temporary tracheal occlusion by means of detachable balloon for congenital diaphragmatic hernia.
Occlusion of the fetal trachea blocks the egress of fetal lung fluid and stimulates the growth of hypoplastic lungs in fetuses with diaphragmatic hernia. Accomplishing temporary and reversible occlusion of the fetal trachea has proven difficult without invasive fetal surgery. Using simultaneous real-time ultrasonography and fetal bronchoscopy through a single uterine port, we placed a detachable balloon in the trachea of 2 fetuses with severe diaphragmatic hernia. In both fetuses the fetal lung subsequently enlarged, allowing survival after birth.
Harrison
M R
MR
Department of Surgery, and the Fetal Treatment Center, University of California, San Francisco 94143-0570, USA.
Albanese
C T
CT
Hawgood
S B
SB
Farmer
D L
DL
Farrell
J A
JA
Sandberg
P L
PL
Filly
R A
RA
D000328:Adult; D021721:Balloon Occlusion; D001999:Bronchoscopy; D003199:Computer Systems; D005314:Embryonic and Fetal Development; D005260:Female; D005332:Fetoscopy; D006548:Hernia, Diaphragmatic / Q000196:embryology / Q000628:therapy*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D008168:Lung / Q000196:embryology; D014132:Trachea; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal