title: [Complex segregation analysis of systemic lupus erythematosus].
abstract: OBJECTIVE
  To explore the genetic model of systemic lupus erythematosus(SLE).
  
  
  METHODS
  Complex segregation analysis was performed by using statistical analysis for genetic epidemiology-REGTL(SAGE-REGTL). The genetic model and gene frequency were estimated. 300 pedigrees with SLE were collected from 300 patients as probands.
  
  
  RESULTS
  The complex segregation analysis found the genetic model of SLE to be additive,the gene frequency 0.336. The authors believe the possibility of some different modes coexisting under different circumstances. The genetic effect on young man is stronger than that on old one.
  
  
  CONCLUSIONS
  This study suggests that the genetic mode of SLE could be the major gene trait, and additive mode is the best fitted one.
authors.affiliation: Department of Maternal and Child Health, Shanghai Medical University, Shanghai, 200032 P.R. China. fmshen@shmu.edu.cn
authors.forename: P
authors.initials: P
authors.lastname: Ni
authors.forename: F
authors.initials: F
authors.lastname: Shen
authors.forename: W
authors.initials: W
authors.lastname: Meng
authors.forename: F
authors.initials: F
authors.lastname: Jiang
authors.forename: S
authors.initials: S
authors.lastname: Feng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic