[Changes in the local nonspecific immune response to post-traumatic inflammation during treatment].
Clinical investigation have been done in adult patients with broken mandible during 3 weeks of conservative treatment with aluminum splints (1st group, n = 17) or steel splints (2nd group, n = 16) in comparison with health adults (control group, n = 18). The neutrophil emigration into alterative locus and their degranulation as well as phagocytic activity of peripheral blood neutrophils were tested. It was found that aluminum splint application caused the intensive inflammation and then the depression of local host defense reactions. Treatment with steel splints did not lead to neutrophil function depletion or to hyper-intensification of inflammatory reaction in patients. The increased values of neutrophil reactions were normalized in this group at the final period of the treatment. The examined trial ensures our accurate method in treatment of patients with broken mandible. The determination of local host defense state may be proposed as preferable simple express-method of evaluation of immune status, treatment efficiency and prognosis in these patients.
Tymofeiev
O O
OO
A.A. Bogomoletz Institute of Physiology, NAS of Ukraine, Shupyk Kiev Medical Academy of Post-graduation Education.
Horobets'
O V
OV
Portnychenko
A H
AH
Rozova
K V
KV
Seredenko
M M
MM
Portnichenko
V I
VI
Abbas
J A
JA
D000293:Adolescent; D000328:Adult; D000535:Aluminum / Q000009:adverse effects / Q000276:immunology; D005592:Fracture Fixation / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008337:Mandibular Fractures / Q000276:immunology* / Q000628:therapy*; D018375:Neutrophil Activation; D020556:Neutrophil Infiltration; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis; D013165:Splints / Q000009:adverse effects*; D013232:Steel / Q000009:adverse effects; D016896:Treatment Outcome
D013232:Steel; D000535:Aluminum