Model-based administration of inhalation anaesthesia. 2. Exploring the system model.
We explored our model by displaying its new capabilities, testing its sensitivity to variations in input data and illustrating its use. Its multiple-gas character allows simulation of the mechanisms governing concentration and second gas effects. Simulating the volume of a standing bellows makes it possible to test algorithms for automated closed-circuit anaesthesia. Using desflurane, the model's sensitivity to changes in blood/gas partition coefficient (range 0.42-0.576), cardiac output and minute ventilation was analysed. The model was very sensitive to changes in blood solubility; other results agreed with those reported previously. An alveolar isoflurane tension of 1% atm was rapidly attained and maintained, even using 0.5 litres min(-1) of fresh gas, when isoflurane was 'co-administered' through a vaporizer set to 3.5 vol% and a single aliquot (1.25 ml liquid) injected into the expiratory limb. As a result of its credibility and capabilities, the model is to be tested in the clinical setting.
Lerou
J G
JG
Institute for Anaesthesiology, University of Nijmegen, The Netherlands.
Booij
L H
LH
D000465:Algorithms; D000764:Anesthesia, Closed-Circuit; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D000077335:Desflurane; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D008954:Models, Biological; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012680:Sensitivity and Specificity
D018685:Anesthetics, Inhalation; D002245:Carbon Dioxide; D000077335:Desflurane; D007530:Isoflurane; D010100:Oxygen