Nuclear volume and prognosis in ovarian cancer.
The prognostic value of the volume-weighted mean nuclear volume (MNV) was investigated retrospectively in 100 ovarian cancer patients with FIGO-stage IB-II (n = 51) and stage III-IV (n = 49) serous tumors. No association was demonstrated between the MNV and the survival or between the MNV and two of five additional parameters: age and amount of residual tumor. However, both in stage IB-II and stage III-IV carcinomas, the MNV increased significantly with increasing tumor grade and DNA-index. Furthermore, FIGO-stage IB-II patients had significantly smaller nuclei than patients with stage III-IV disease.
Mogensen
O.
O
Danish Cancer Society, Department of Immunoserology, Nørrebrogade 44, DK-8000 Aarhus C; Stereological Research Laboratory, University of Aarhus, Bartholin Building, DK-8000 Aarhus C; University Institute of Pathology, Aarhus University Hospital, DK-8000 Aarhus C; Institute of Pathology, Vejle Hospital, DK-7100 Vejle; and Department of Oncology, Aarhus University Hospital, DK-8000 Aarhus C, Denmark.
Sørensen
F.B.
FB
Bichel
P.
P
Jakobsen
A.
A