A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK).
[structure: see text]. A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.
Zheng
Y
Y
Center for Supramolecular Science and Department of Chemistry, University of Miami, PO Box 249118, Coral Gables, Florida 33124, USA.
Huo
Q
Q
Kele
P
P
Andreopoulos
F M
FM
Pham
S M
SM
Leblanc
R M
RM
D000873:Anthracenes / Q000138:chemical synthesis; D015374:Biosensing Techniques; D003300:Copper / Q000032:analysis*; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D019216:Metals, Heavy / Q000032:analysis; D009842:Oligopeptides / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence
D000873:Anthracenes; D019216:Metals, Heavy; D009842:Oligopeptides; C020905:glycyl-histidyl-lysine; C010030:9-anthroic acid; D003300:Copper