title: Effect of salbutamol on lung function parameters of healthy children.
abstract: In the present study, the effect of 200 microg salbutamol compared to placebo was evaluated on lung function parameters of 37 healthy children aged 7-14 years. Salbutamol or placebo were administered, using a single blind study design, and spirometry was performed before and after 10 min of inhalation. At the time of the study, all children were symptom-free and had not suffered from any respiratory infection during the previous 4 weeks. The administration of salbutamol resulted in a significant increase of mean forced expiratory volume in 1 s (111%-115%, P<0.05), maximal expiratory flow at 50% of forced vital capacity (101%-110%, P<0.05) and maximal expiratory flow at 25 % of forced vital capacity (96%-115%, P<0.05). The administration of placebo resulted in no significant change in lung function parameters.
  
  
  CONCLUSIONS
  The administration of 200 microg salbutamol results in the occurrence of a small but significant bronchodilation in healthy, non-asthmatic children.
authors.affiliation: Department of Paediatrics, University Hospital Antwerp, Edegem-Antwerp, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Delanghe
authors.forename: K N
authors.initials: KN
authors.lastname: Desager
authors.forename: H P
authors.initials: HP
authors.lastname: Van Bever
mesh_terms: D000293:Adolescent; D000420:Albuterol / Q000494:pharmacology*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002648:Child; D005260:Female; D005540:Forced Expiratory Flow Rates / Q000187:drug effects; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008297:Male; D008448:Maximal Expiratory Flow Rate / Q000187:drug effects; D012016:Reference Values; D016037:Single-Blind Method; D013147:Spirometry
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol