A two-component signal-transduction cascade in Carnobacterium piscicola LV17B: two signaling peptides and one sensor-transmitter.
In the lactic acid bacterium Carnobacterium piscicola LV17B a peptide-pheromone dependent quorum-sensing mode is involved in the regulation of bacteriocin production. Bacteriocin CB2 was identified as an environmental signal that induces bacteriocin production. Here, we demonstrate that a second 24 amino acid peptide (CS) also induces bacteriocin production. Transcription activation of several carnobacteriocin operons is triggered by CB2 or CS via a two-component signal transduction system composed of CbnK and CbnR.
Kleerebezem
M
M
Wageningen Centre for Food Sciences; NIZO food-research, Department of Flavour and Natural Ingredients, P. O. Box 20, 6710 BA Ede, The Netherlands.
Kuipers
O P
OP
de Vos
W M
WM
Stiles
M E
ME
Quadri
L E
LE
D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001430:Bacteriocins / Q000096:biosynthesis* / Q000235:genetics* / Q000378:metabolism; D005809:Genes, Regulator / Q000235:genetics*; D007777:Lactobacillaceae; D009876:Operon / Q000235:genetics; D010455:Peptides / Q000235:genetics* / Q000378:metabolism*; D010675:Pheromones / Q000235:genetics / Q000378:metabolism; D010957:Plasmids / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000187:drug effects / Q000235:genetics*; D015398:Signal Transduction / Q000502:physiology
D001426:Bacterial Proteins; D001430:Bacteriocins; D010455:Peptides; D010675:Pheromones; C086963:bacteriocin B2 protein, Carnobacterium piscicola