QSAR of anticancer compounds. Bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides).
QSAR have been developed for the anticancer activity (growth inhibition) of various tumor cells by bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides). Of the seven QSAR, positive hydrophobic interactions are found in only two examples: bis(naphthalimides) versus human colon cancer cells. This is consistent with other QSAR of anticancer compounds where hydrophobic interactions are found to be unimportant.
Mekapati
S B
SB
Department of Chemistry, Pomona College, Claremont, CA 91711, USA.
Denny
W A
WA
Kurup
A
A
Hansch
C
C
D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007094:Imides / Q000737:chemistry; D007192:Indenes / Q000737:chemistry; D020128:Inhibitory Concentration 50; D051379:Mice; D010619:Phenazines / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D011804:Quinolines / Q000737:chemistry; D015363:Quinolones / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000187:drug effects
C431771:11-oxo-11H-indeno(1,2-b)quinolinecarboxamide; D000970:Antineoplastic Agents; D007094:Imides; D007192:Indenes; D010619:Phenazines; D011804:Quinolines; D015363:Quinolones; C420923:phenazine-1-carboxamide; D015057:1-Naphthylamine