title: Efficient synthesis of lactosaminylated core-2 O-glycans.
abstract: A series of lactosaminylated oligosaccharides found in mucin type O-glycans was synthesized using a generalized block strategy. The synthesis involved the addition of a protected lactosamine donor to a partially protected T-disaccharide derivative. The nonreducing galactose residues of the deblocked oligosaccharide products could be removed by beta-galactosidase from jack bean to produce the corresponding GlcNAc terminated compounds. A series of tri- to hexasaccharides was thus efficiently produced.
authors.affiliation: The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. anup@chem-biotek.com
authors.forename: A K
authors.initials: AK
authors.lastname: Misra
authors.forename: M
authors.initials: M
authors.lastname: Fukuda
authors.forename: O
authors.initials: O
authors.lastname: Hindsgaul
mesh_terms: D000606:Amino Sugars / Q000737:chemistry*; D004187:Disaccharides / Q000737:chemistry; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000606:Amino Sugars; D004187:Disaccharides; D011134:Polysaccharides; C032233:lactosamine