Primary sclerosing cholangitis in patients with inflammatory bowel disease in Turkey.
BACKGROUND
Primary sclerosing cholangitis (PSC), which is a progressive cholestatic liver disease of unknown etiology, is strongly correlated with inflammatory bowel disease (IBD).


OBJECTIVE
To determine the prevalence and describe the characteristics of PSC in patients with IBD in Turkey.


METHODS
We determined the prevalence of PSC in patients with IBD admitted to our department during a 6-year period. Also, patients with PSC were investigated from an IBD aspect. Regardless of whether the patient had symptoms such as itching, jaundice, and abdominal pain, endoscopic retrograde cholangiopancreatography was performed on those with elevated alkaline phosphatase, and liver biopsy was done if endoscopic retrograde cholangiopancreatography failed to bring about the diagnosis.


RESULTS
Overall prevalence of PSC was 9 of 386 (2.3%) patients with ulcerative colitis (UC) and 4 of 110 (3.6%) patients with Crohn's disease (CD). Inflammatory bowel disease was established in 13 of 18 (72.2%; UC, 50.0%; CD, 22.2%) patients who were being observed for PSC. The male-to-female ratio was 5:4 in UC and 3:1 in CD patients with PSC. The mean age at diagnosis of PSC was 43.6 years (range, 30-54 years) in patients with UC and 30.5 years (range, 26-41 years) in patients with CD. In patients with UC, the extension of colitis was total in seven patients (7/110, 6.3%) and left-sided in two patients (2/142, 1.4%). In patients with CD, the disease was located in the ileum and colon in one patient (1/47, 2.1%) and in colon alone in three patients (3/21, 14.2%).


CONCLUSIONS
Prevalence of PSC-associated IBD in the Turkish community appear to be similar to the results of western origin studies.
Parlak
E
E
Turkiye Yuksek Ihtisas Hospital, Department of Gastroenterology, Ankara, Turkey.
Kosar
Y
Y
Ulker
A
A
Dagli
U
U
Alkim
C
C
Sahin
B
B
D000328:Adult; D017677:Age Distribution; D002758:Cholangiography; D015209:Cholangitis, Sclerosing / Q000175:diagnosis / Q000453:epidemiology*; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology; D016145:Endoscopy, Digestive System; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D015996:Survival Rate; D014421:Turkey / Q000453:epidemiology