title: Additional dark G-band in the p-arm of chromosome 19 due to a paracentric inversion with a breakpoint in the pericentromeric heterochromatin.
abstract: Paracentric inversions in chromosome 19 have rarely been described. Here we present an inv(19)(p11p13.1) with a breakpoint in the pericentromeric heterochromatin which leads to an additional dark G-band in the p-arm of chromosome 19. The rearranged chromosome segregated in two generations of a family without any phenotypic effects. A detailed characterization of the inv(19) by molecular cytogenetic techniques is presented.
authors.affiliation: Institut für Anthropologie und Humangenetik, LMU München, Goethestrasse 31, D-80336 Munich, Germany. fauth@fish.med-muenchen.de
authors.forename: C
authors.initials: C
authors.lastname: Fauth
authors.forename: I
authors.initials: I
authors.lastname: Bartels
authors.forename: T
authors.initials: T
authors.lastname: Haaf
authors.forename: M R
authors.initials: MR
authors.lastname: Speicher
mesh_terms: D000328:Adult; D000649:Amniocentesis; D002503:Centromere / Q000235:genetics*; D002871:Chromosome Banding; D019457:Chromosome Breakage; D007446:Chromosome Inversion; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D006570:Heterochromatin / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011247:Pregnancy
chemical_list: D006570:Heterochromatin