title: Prognostic factors and adjuvant treatment in early epithelial ovarian cancer.
abstract: Four hundred and ten patients with epithelial ovarian cancer FIGO stages I and II were registered by a Danish multicenter study group (The Danish Ovarian Cancer Group - DACOVA). Two-thirds were stage I, the most frequent substage was Iai which was the classification in 27%. Five-year survival for stage I was 72%, and 38% for stage II. Multivariate analysis showed that age, stage, residual tumor, histologic grade and adjuvant treatment had prognostic value. For stage, three significantly different groups could be identified: (1) stage Iai, (2) stage Iaii-Ic, and (3) stage II. Histologic grade showed a significant survival difference between all grades. Adjuvant treatment had a moderate but significant impact on survival. Patients in stage Iai had a good survival with surgery alone and will probably not benefit from adjuvant therapy. Adjuvant treatment improved survival for the remaining patients in stages I and II without residual tumor. A difference between treatment modalities was not observed. However, the data need to be confirmed by a randomized trial. Patients in stage II with residual tumor should be treated as stage III.
authors.affiliation: Department of Oncology, Odense University Hospital, DK-5000, Denmark.
authors.forename: K.
authors.initials: K
authors.lastname: Bertelsen
authors.forename: B.
authors.initials: B
authors.lastname: Hølund
authors.forename: J.E.
authors.initials: JE
authors.lastname: Andersen
authors.forename: K.
authors.initials: K
authors.lastname: Nielsen
authors.forename: I.
authors.initials: I
authors.lastname: Strøyer
authors.forename: P.
authors.initials: P
authors.lastname: Ladehoff