Intravesical oxybutynin affects bladder permeability.
To investigate the effects of intravesical application of oxybutynin chloride on bladder permeability we designed an animal model. Female Guinea pigs were given 3 different test solutions: phosphate buffered saline (PBS), 50% acetone and 1.27 x 10(-2) M oxybutynin chloride solution. Then 99mTc-DTPA 45 microCi in 2 ml normal saline was instilled into the bladder lumen in each animals and allowed to dwell for 30 minutes. At the end of exposure time, the net count data in each 1 ml serum sample were corrected for radioactive decay and converted to the total percentage of administered dose. 99mTc-DTPA absorption percentages of both acetone and oxybutynin groups were significantly higher than that of PBS group (mean 3.2 +/- 2.9% p < 0.001). Intravesical oxybutynin application increases bladder permeability 5 times compared with PBS administration. This observation can also explain how rapid absorption of oxybutynin through the bladder into the systemic circulation occurs.
Ersay
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Dicle University Medical School Department of Urology, Diyarbakir, Turkey. aersay@dicle.edu.tr
Demirtas
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D000283:Administration, Intravesical; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D008333:Mandelic Acids / Q000493:pharmacokinetics / Q000494:pharmacology*; D023421:Models, Animal; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate; D001743:Urinary Bladder / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism
D008333:Mandelic Acids; D019275:Radiopharmaceuticals; C005419:oxybutynin; D016284:Technetium Tc 99m Pentetate