Evidence that behavioral depression does not influence airway cell influx in allergic rats.
This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applied on day 0, 7 and 13 after OVA sensitization, was used as a model to induce depression. In both nondepressed and depressed groups, the number of total and differential cells (eosinophils and mononuclear cells) in BAL fluid was significantly larger in sensitized compared with non-sensitized animals. However, no statistical differences were found between these groups with respect to the number of total and differential leukocytes, irrespective of the day inescapable shock was applied. Thus, behavioral depression does not influence the pattern of cell infiltration into the airways of allergen-induced airway inflammation.
Varriano
M A
MA
Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas (SP), Brazil.
Varriano
A A
AA
Datti
F
F
Datti
M
M
Antunes
E
E
Teixeira
N A
NA
D000818:Animals; D001249:Asthma / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D003863:Depression / Q000276:immunology*; D004558:Electric Stimulation; D005260:Female; D007114:Immunization; D007958:Leukocyte Count; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar
D010047:Ovalbumin