title: Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity.
abstract: Jejunal infusions of linoleic acid, corn oil, or caprylic acid significantly increased hepatic vagal afferent activity, whereas saline infusions were ineffective. The magnitude of response was greatest with either linoleic acid or corn oil. Hepatic portal infusions of linoleic acid, Liposyn II, or caprylic acid significantly increased hepatic vagal afferent activity, whereas 5% albumin/phosphate buffer vehicle was ineffective. The magnitude of response was greatest with either linoleic acid or Liposyn II. These data show that either jejunal or portal infusions of lipids increase activity of hepatic vagal afferents and could potentially serve as a complementary and/or alternative substrate to celiac vagal afferents in mediating the effects of jejunal infusions of lipids in suppressing food intake.
authors.affiliation: Department of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors.forename: A
authors.initials: A
authors.lastname: Randich
authors.forename: D S
authors.initials: DS
authors.lastname: Spraggins
authors.forename: J E
authors.initials: JE
authors.lastname: Cox
authors.forename: S T
authors.initials: ST
authors.lastname: Meller
authors.forename: G R
authors.initials: GR
authors.lastname: Kelm
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects* / Q000502:physiology; D002210:Caprylates / Q000494:pharmacology; D003314:Corn Oil / Q000494:pharmacology; D007583:Jejunum / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D008297:Male; D011169:Portal Vein / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012844:Sincalide / Q000494:pharmacology; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology; D017833:Visceral Afferents / Q000187:drug effects* / Q000502:physiology; D017962:alpha-Linolenic Acid / Q000494:pharmacology
chemical_list: D002210:Caprylates; D008055:Lipids; D017962:alpha-Linolenic Acid; D003314:Corn Oil; D012844:Sincalide; C031492:octanoic acid