title: Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4(+)-T-cell subsets are determined only by coreceptor expression.
abstract: In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.
authors.affiliation: Department of Clinical Viro-Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Kwa
authors.forename: J
authors.initials: J
authors.lastname: Vingerhoed
authors.forename: B
authors.initials: B
authors.lastname: Boeser-Nunnink
authors.forename: S
authors.initials: S
authors.lastname: Broersen
authors.forename: H
authors.initials: H
authors.lastname: Schuitemaker
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000472:pathogenicity*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D019713:Receptors, CCR5 / Q000032:analysis*; D019718:Receptors, CXCR4 / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000821:virology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000032:analysis
chemical_list: D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D017493:Leukocyte Common Antigens; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1