title: [Influence of huanglian used in combination with huangqin and gancao on the erythrocytic osmotic fragilitas of experimental glucose-6-phosphate dehydrogenase deficiency in rats].
abstract: OBJECTIVE
  To study the influence of common combination of Huanglian(Coptis chinensis) on the erythrocytic osmotic fragilitas of glucose-6-phosphate dehydrogenase(G6PD) deficiency in rats.
  
  
  METHODS
  Various decoctions with Huanglian mixed with Huangqin (Scutellaria baicalensis) and Gancao(Glycyrrhiza uralensis) were orally administered to the G6PD deficiency rat model, and the erythrocytic osmotic fragilitas was measured.
  
  
  RESULTS
  The erythrocytic osmotic fragilitas after the combined use of Huanglian appears lower than (or equal to) that of Huanglian used alone(or even not used). The fragilitas lowers depending largely on the medicine in combination, dosage and proportion.
  
  
  CONCLUSIONS
  Proper use of Huanglian in combination with Huangqin and Gancao is of some significance in lowering the erythrocytic osmotic fragilitas of G6PD deficiency in rats.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700.
authors.forename: N
authors.initials: N
authors.lastname: Lin
authors.forename: X
authors.initials: X
authors.lastname: Gao
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood*; D006035:Glycyrrhiza; D019686:Lamiaceae; D019684:Magnoliopsida; D008297:Male; D009996:Osmotic Fragility / Q000187:drug effects; D008517:Phytotherapy; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal