Synthesis and antibacterial activity of 5- and 6-hydroxy substituted 4-aminoquinolines and derivatives.
The synthesis and antimicrobial activity of 4-amino-8-methylquinolines 8, 11 substituted with a hydroxy- or methoxy-group at 5- and at 6-position have been investigated. The title compounds could be prepared by a six-step procedure according to the literature starting from commercially available anilines 1. The novel 4-aminoquinolines 8,11 exhibited slight antibacterial activity against Gram-positive and Gram-negative bacteria.
Meyer
T
T
Institute of Pharmacy, University of Hamburg, Germany.
Lemcke
T
T
Geffken
D
D
Kaulfers
P M
PM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D011804:Quinolines