Intracerebroventricular injection of pipecolic acid inhibits food intake and induces sleeping-like behaviors in the neonatal chick.
It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-Lysine (L-Lys) in the brain, is involved in the functioning of Gamma-aminobutyric acid. In the present work the effect of intracerebroventricular (i.c.v.) administration of L-PA, and its relatives, on food intake and behavior in neonatal chicks was investigated. The i.c.v. injection of 1 mg of L-PA and D-PA significantly inhibited food intake during the 2 h following injection, whereas greater than 2 mg of L-Lys was required to inhibit food intake. In behavioral tests, the i.c.v. injection of L-PA reduced active wakefulness and feeding behavior while inducing sleeping-like behavior in chicks. These results suggest that L-PA has an important role for the regulation of behaviors in the neonatal chick after conversion from L-Lys in the brain.
Takagi
T
T
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Ando
R
R
Ohgushi
A
A
Yamashita
T
T
Dobashi
E
E
Hussain-Yusuf
H
H
Onodera
R
R
Bungo
T
T
Sato
H
H
Furuse
M
M
D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000502:physiology; D002645:Chickens; D004435:Eating / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D010875:Pipecolic Acids / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*
D010875:Pipecolic Acids; C031345:pipecolic acid