Parkin and the molecular pathways of Parkinson's disease.
Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical pathways underlying the etiology of sporadic PD. Mutations in the parkin gene causal of autosomal recessive juvenile parkinsonism highlight that ubiquitin-mediated proteolysis may play an important role in the pathobiology of PD.
Giasson
B I
BI
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Lee
V M
VM
D017668:Age of Onset; D020816:Amino Acid Motifs; D000818:Animals; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D016631:Lewy Bodies / Q000378:metabolism; D008025:Ligases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism*; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D017510:Protein Folding; D051381:Rats; D013329:Structure-Activity Relationship; D013378:Substantia Nigra / Q000378:metabolism; D051843:Synucleins; D025801:Ubiquitin / Q000502:physiology; D044767:Ubiquitin-Protein Ligases
D009097:Multienzyme Complexes; D009419:Nerve Tissue Proteins; D051843:Synucleins; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D008025:Ligases