[Colon cancer and nutritional genetics: modifier genes].
About 5% of colon cancer cases correspond to classic hereditary monogenic mendelian transmission involving at least 8 major genes of predisposition to this tumor. Genes with more moderate effects, in association with other genes can contribute to the occurrence of sporadic polygenic forms. These genes confer susceptibility to environmental factors and can play the role of aggravating or protective modifier genes in the different hereditary forms. Foods can interact with these genes and modulate their expression. Moreover sequence variations (polymorphisms) in these genes may also be responsible for slower or more rapid metabolism of nutrients leading to toxic or carcinogenic compounds. If some foods, or "pharmafoods" can have beneficial effects in some individuals with a particular subtype of the disease, others can be inefficient or even detrimental in patients with the same disease but with a different genetic origin or if the genetic background is different. Moreover tumorigenic processes are diverse. Tumor progression depends on genetic and environmental factors different from tumor initiation and on the site of the tumor along the colon tract. Interactions with the gut flora, the lymphoid system and specific features of growth of the colon mucosa are also important parameters. Today with a formidable genetic knowledge arising from the genome project, new epidemiological data integrating the genetic data for multiple markers and a better knowledge of the tumorigenic processes involved, a new discipline is emerging. "Nutrigenetics" which is the study of hereditary basis of individual variations in response to foods opens for the oncoming decade the era of a personalised predictive medecine based on a nutrition adapted to the genetic make up of each of us.
Junien
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INSERM UR 383, Groupe Hospitalier Necker - Enfants Malades, 149, rue de Sèvres, 75015 Paris, France.
D003043:Cocarcinogenesis; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000517:prevention & control; D004032:Diet / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D008967:Molecular Biology / Q000379:methods; D009747:Nutritional Physiological Phenomena; D011110:Polymorphism, Genetic / Q000235:genetics; D011237:Predictive Value of Tests; D012307:Risk Factors; D015262:Xenobiotics / Q000009:adverse effects / Q000378:metabolism
D005819:Genetic Markers; D015262:Xenobiotics