title: Modified dinucleoside tetraphosphonates, new potential inhibitors of HIV reverse transcriptase.
abstract: New gamma-substituted analogues of dNTP were synthesized and their enzymatic stability and antiviral properties were evaluated.
authors.affiliation: Engelhardt Instiute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov St., Moscow 117984, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Shirokova
authors.forename: A L
authors.initials: AL
authors.lastname: Khandazhinskaya
authors.forename: Y S
authors.initials: YS
authors.lastname: Skoblov
authors.forename: L Y
authors.initials: LY
authors.lastname: Goryunova
authors.forename: R S
authors.initials: RS
authors.lastname: Beabealashvilli
authors.forename: A A
authors.initials: AA
authors.lastname: Krayevsky
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D015226:Dinucleoside Phosphates / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D004355:Drug Stability; D005347:Fibroblasts / Q000821:virology; D006678:HIV / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D008979:Moloney murine leukemia virus / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D018894:Reverse Transcriptase Inhibitors / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D015226:Dinucleoside Phosphates; D018894:Reverse Transcriptase Inhibitors