[Microalbuminuria, pulse wave velocity and common carotid artery intima-media thickness in type 2 diabetes].
The aim of the study was to evaluate pulse wave velocity (PWV) and carotid intima-media thickness (IMT) in type 2 diabetics with microalbuminuria (mualb). The study concerned 37 patients type 2 diabetics, age: 53.4 +/- 6.6, years free of cardiovascular complications. HbA1C was 7.73 +/- 1.39%, waist circumference 104.2 +/- 11.7 cm. 19 patients with BP > 130/85 mmHg were identified as mild hypertensives (17/19 under treatment). All patients underwent ABPM, PWV and IMT measurements. The study population was separated into 2 subgroups according to median of mualb (mg/24 h): 18.9. [table: see text] In patients with mualb > 18.9 mg/24, IMT and PWV were significantly increased (p = 0.06; p < 0.01). After adjustment to BP and age, there was no significant difference in IMT and PWV in the subgroups. In this selected population of type 2 diabetics, microalbuminuria appears associated to a pressure-dependant vascular remodeling.
d'Esteve-Bonetti
L
L
Service de médecine interne et d'hypertension CHU Purpan, Toulouse.
Amar
J
J
Hanaire-Broutin
H
H
Brillac
T
T
Calazel-Fournier
C
C
Hernandez
G
G
Salvador
M
M
Chamontin
B
B
D000419:Albuminuria / Q000209:etiology* / Q000473:pathology; D002339:Carotid Arteries / Q000033:anatomy & histology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017539:Tunica Intima / Q000033:anatomy & histology* / Q000473:pathology; D020257:Ventricular Remodeling