title: Animal models of infection and inflammation and their role in experimental nuclear medicine.
abstract: In this review, basic aspects of nuclear medicine are described. One of the fields of research in nuclear medicine is the development of new radiopharmaceuticals for imaging infection and inflammation in humans. For this development, animal models are identified and modified to needs of a particular research question. In this review, a wide variety of models that are available in our laboratory are presented and the strengths and pitfalls are discussed.
authors.affiliation: Department of Nuclear Medicine (565), University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. w.oyen@nugen.azu.nl
authors.forename: W J
authors.initials: WJ
authors.lastname: Oyen
authors.forename: O C
authors.initials: OC
authors.lastname: Boerman
authors.forename: F H
authors.initials: FH
authors.lastname: Corstens
mesh_terms: D000818:Animals; D003092:Colitis / Q000000981:diagnostic imaging; D004195:Disease Models, Animal; D004696:Endocarditis / Q000000981:diagnostic imaging; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging*; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging; D009683:Nuclear Medicine / Q000379:methods*; D010019:Osteomyelitis / Q000000981:diagnostic imaging; D011014:Pneumonia / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use
chemical_list: D019275:Radiopharmaceuticals