New clues to the puzzle of mammalian sex determination.
WT1 and SOX9 are transcription factors with critical roles in mammalian sex determination and gonadal development. Recent studies in vivo clarify the roles of two alternative splice isoforms of WT1, and demonstrate that SOX9 can induce male sex determination.
Bowles
J
J
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. p.koopman@imb.uq.edu.au
Koopman
P
P
D000818:Animals; D024282:Genes, sry / Q000235:genetics; D006609:High Mobility Group Proteins / Q000235:genetics; D006801:Humans; D055758:SOX9 Transcription Factor; D019849:Sex Determination Processes; D014157:Transcription Factors / Q000235:genetics; D025721:WT1 Proteins / Q000235:genetics
D006609:High Mobility Group Proteins; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D014157:Transcription Factors; D025721:WT1 Proteins