[Frequency of duodenal adenomas in patients with familial adenomatous polyposis].
OBJECTIVE
To estimate the prevalence of polyps in the stomach and duodenum in patients with familial adenomatous polyposis (FAP), and to examine the relationship between age and severity of duodenal adenomatosis.


METHODS
Retrospective.


METHODS
Using the FAP-registry of the Netherlands Foundation for the Detection of Hereditary Tumours, data were obtained from patients who had undergone a gastroduodenoscopy before 1 July 1999. The endoscopic and histological findings were used to classify the duodenal adenomas according to the Spigelman classification.


RESULTS
224 patients had undergone at least one gastroduodenoscopy: 117 men and 107 women with a mean age at the time of the first endoscopy of 37 years (range: 13-78). Fundic gland polyposis was detected in 79 patients (35%), stomach adenomas in 6 patients (3%) and duodenal adenomas in 92 patients (41%). A total of 21 patients (9%) had severe duodenal adenomatosis (Spigelman III or IV). Duodenal adenomatosis was often more severe if the patient was older. Ten patients were known to have duodenal cancer; the mean age at diagnosis was 50.3 years (range: 39-67).


CONCLUSIONS
Nearly 10% of the patients with FAP had developed severe duodenal adenomatosis. The severity of duodenal adenomatosis was related to the patient's age.
van Ruth
S
S
Universitair Medisch Centrum, afd. Heelkunde, Utrecht.
de Vos tot Nederveen Cappel
W H
WH
van Laarhoven
C J
CJ
Vasen
H F
HF
D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology*; D011125:Adenomatous Polyposis Coli / Q000150:complications*; D000328:Adult; D000367:Age Factors; D000368:Aged; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000556:secondary; D004384:Duodenoscopy; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012720:Severity of Illness Index