RNA binding proteins and selenocysteine.
Selenocysteine is incorporated into protein by a complex co-translational mechanism that involves both cis and trans acting factors. Among the trans-acting factors are RNA binding proteins that interact with the selenoprotein 3' UTRs at a sequence known as the selenocysteine insertion sequence (SECIS). These factors are generally referred to as SBPs, and in this review we will discuss the history of the SBPs, and give a detailed description of the recently identified SBP2 which is the only SBP known to be required for Sec insertion. The mechanism by which SBP2 may be involved in this process will be discussed.
Copeland
P R
PR
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. copelap@ccf.org
Driscoll
D M
DM
D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D004251:DNA Transposable Elements; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012345:RNA, Transfer, Amino Acid-Specific / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*; D017279:Selenocysteine / Q000378:metabolism*; D051140:Selenoproteins
D020413:3' Untranslated Regions; D004251:DNA Transposable Elements; D011506:Proteins; D012333:RNA, Messenger; D012345:RNA, Transfer, Amino Acid-Specific; D016601:RNA-Binding Proteins; C121530:SECISBP2 protein, human; D051140:Selenoproteins; C036928:tRNA, selenocysteine-; D017279:Selenocysteine