title: An enantioselective strategy to macrocyclic bisindolylmaleimides. An efficient formal synthesis of LY 333531.
abstract: [reaction: see text]. The ability to employ a bromo alcohol as a nucleophile in a palladium-catalyzed dynamic kinetic asymmetric transformation leads to an efficient synthesis of a selective PKC inhibitor under clinical development.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@leland.stanford.edu
authors.forename: B M
authors.initials: BM
authors.lastname: Trost
authors.forename: W
authors.initials: W
authors.lastname: Tang
mesh_terms: D002384:Catalysis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D007211:Indoles / Q000138:chemical synthesis*; D008301:Maleimides / Q000138:chemical synthesis*; D015394:Molecular Structure; D010165:Palladium; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D013237:Stereoisomerism
chemical_list: D004791:Enzyme Inhibitors; D007211:Indoles; D008301:Maleimides; D010165:Palladium; C099154:ruboxistaurin; D011493:Protein Kinase C