title: Combinatorial evaluation of the chiral discrimination of permethylated carbohydrates using fast-atom bombardment mass spectrometry.
abstract: The chiral discrimination abilities of several variously permethylated carbohydrates toward various amino acid 2-propyl esters were combinatorially evaluated from the relative peak intensity of the 1:1 diastereomeric complex ions with the deuterium-labeled L-amino acid 2-propyl ester protonated ion and with the unlabeled D-amino acid 2-propyl ester protonated ions in FAB mass spectrometry. The chiral discrimination abilities evaluated using FAB mass spectrometry approximately corresponded to the ratio of the association constants (K(R)/K(S)) toward each enantiomer in the solution. Therefore, this evaluation method is very useful for the screening of the chiral discrimination abilities of carbohydrates and their derivatives.
authors.affiliation: Osaka Municipal Technical Research Institute, 1-6-50 Morinomiya, Joto-ku, Osaka 536-8553, Japan. shizuma@omtri.city.osaka.jp
authors.forename: M
authors.initials: M
authors.lastname: Shizuma
authors.forename: H
authors.initials: H
authors.lastname: Adachi
authors.forename: Y
authors.initials: Y
authors.lastname: Takai
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: J
authors.initials: J
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Sawada
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002241:Carbohydrates / Q000032:analysis / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents / Q000737:chemistry; D008745:Methylation; D016339:Spectrometry, Mass, Fast Atom Bombardment / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D007202:Indicators and Reagents