[Studies on triterpenoids and their glycosides from Aralia dasyphylla Miq].
The structures of two triterpenoids and their glycosides were isolated from Aralia dasyphylla Miq. Their structures have been identified to be oleanoic acid(I), 16 beta-hydroxy-18 beta-H-oleanoic acid(II), oleanoic acid-28-O-beta-D-glucopyranoside(III) and 16 beta-hydroxy-18 beta-H-oleanoic acid-28-O-beta-D-glucopyranoside(IV), respectively, mainly through interpretation of UV, IR, MS, 1H and 13CNMR, DEPT, HMQC and HMBC spectra data. The stereochemistry of II has been confirmed by NOESY. Pharmacological experiments showed that the total saponins exerted preventative effect on CCl4-induced liver injury of male mice and hypoglycemic effect on a model of alloxan-induced diabetes in rats.
Yi
Y H
YH
Department of Medical Chemistry of Natural Products, School of Pharmacy, Second Military Medical University, Shanghai 200433.
Gu
J Q
JQ
Xiao
K
K
Wang
Z Z
ZZ
Lin
H W
HW
D000818:Animals; D027983:Aralia / Q000737:chemistry*; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009828:Oleanolic Acid; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use
D006027:Glycosides; D007004:Hypoglycemic Agents; D014315:Triterpenes; D009828:Oleanolic Acid