The peroxisome in oxidative stress.
Peroxisomes are one of the main sites in the cell where oxygen free radicals are both generated and scavenged. The balance between these two processes is believed to be of great importance for proper functioning of cells and has been implicated in aging and carcinogenesis. We will give an overview of the peroxisomal processes involved in the oxygen radical homeostasis and its implications for the cell.
Dansen
T B
TB
Institute of Biomembranes, Centre for Biomembranes and Lipid Enzymology, Department of Biochemistry of Lipids, Utrecht University, The Netherlands.
Wirtz
K W
KW
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D016166:Free Radical Scavengers / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D015227:Lipid Peroxidation; D008954:Models, Biological; D018384:Oxidative Stress; D020675:Peroxisomes / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species