[Complex segregation analysis of systemic lupus erythematosus].
OBJECTIVE
To explore the genetic model of systemic lupus erythematosus(SLE).


METHODS
Complex segregation analysis was performed by using statistical analysis for genetic epidemiology-REGTL(SAGE-REGTL). The genetic model and gene frequency were estimated. 300 pedigrees with SLE were collected from 300 patients as probands.


RESULTS
The complex segregation analysis found the genetic model of SLE to be additive,the gene frequency 0.336. The authors believe the possibility of some different modes coexisting under different circumstances. The genetic effect on young man is stronger than that on old one.


CONCLUSIONS
This study suggests that the genetic mode of SLE could be the major gene trait, and additive mode is the best fitted one.
Ni
P
P
Department of Maternal and Child Health, Shanghai Medical University, Shanghai, 200032 P.R. China. fmshen@shmu.edu.cn
Shen
F
F
Meng
W
W
Jiang
F
F
Feng
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic