title: HveC (nectin-1) is expressed at high levels in sensory neurons, but not in motor neurons, of the rat peripheral nervous system.
abstract: The entry of herpes simplex virus (HSV)-1 into cells is a complex process mediated in part by the binding of the HSV glycoprotein D (gD) to a specific cellular receptor identified as HveC, or nectin-1. We examined the distribution of HveC in sensory and motor neurons of the peripheral nervous system (PNS) by immunocytochemistry. HveC is expressed at high levels in sensory neurons of dorsal root ganglion and their peripheral axons, at lower levels in motor neurons of spinal cord, and without detectable expression in motor nerve terminals at the neuromuscular junction. These results have implications regarding the tropism of HSV to specific neuronal populations, and for the construction of HSV-based vectors for the peripheral nervous system.
authors.affiliation: Departments of Neurology, Molecular Genetics and Biochemistry, University of Pittsburgh, Pennsylvania, USA.
authors.forename: M
authors.initials: M
authors.lastname: Mata
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.forename: D J
authors.initials: DJ
authors.lastname: Fink
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D003964:Diaphragm / Q000294:innervation; D005727:Ganglia, Spinal / Q000378:metabolism*; D015967:Gene Expression Regulation, Viral; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D009046:Motor Neurons / Q000378:metabolism*; D000075983:Nectins; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D009475:Neurons, Afferent / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018139:Simplexvirus / Q000502:physiology*; D013045:Species Specificity; D014034:Toes / Q000294:innervation
chemical_list: D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; C000619010:NECTIN1 protein, human; C000619015:Nectin1 protein, mouse; D000075983:Nectins; D009419:Nerve Tissue Proteins