title: [Organophosphate poisoning in inexperienced workers].
abstract: Organophosphates are frequently used as insecticides in agricultural areas, therefore they may pose a risk for accidental exposure by dermal contact or through inhalation. We present the cases of eight young men, who worked unprotected and inexperienced with organophosphates. They were exposed dermally and developed mainly gastrointestinal symptoms and also diaphoresis, hypersalivation, blurred vision and miosis. One patient developed severe weakness, fasciculations, disorientation and sleepiness. All had low levels of plasma acetylcholinesterase. All were admitted to the hospital and received antidotal treatment of atropine and toxogonin. They were released after 48 hours in good physical condition. The hospital staff rapidly diagnosed the organophosphate intoxication; additional doctors and nurses were called to the emergency department. The patients were decontaminated in showers within the hospital. This case emphasizes the need for workers handling pesticides, to be supervised by an experienced person and the advantages of hospital drills in rapid diagnosis and preparedness to provide treatment to many patients.
authors.affiliation: Obstetrics and Gynecology Department, Sheba Medical Center.
authors.forename: A
authors.initials: A
authors.lastname: Weissmann
authors.forename: E
authors.initials: E
authors.lastname: Elran
authors.forename: S
authors.initials: S
authors.lastname: Givoni
authors.forename: L
authors.initials: L
authors.lastname: Poles
authors.forename: B
authors.initials: B
authors.lastname: Tadmor
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000172:deficiency; D000293:Adolescent; D000328:Adult; D004630:Emergencies; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D007557:Israel; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D009943:Organophosphorus Compounds
chemical_list: D007306:Insecticides; D009943:Organophosphorus Compounds; D000110:Acetylcholinesterase