title: Preliminary results on the effects of CD40/CD40L interactions and SAC-induction on IFN-gamma expression in human schistosomiasis.
abstract: In this communication the authors analyzed the pattern of expression of IFN-gamma as a surrogate type 1 response in different clinical forms of schistosomiasis in response to stimulation involving T-cell dependent and T-cell independent pathways, to investigate which pathways were functional in human schistosomiasis, and to further characterize the nature of Th1 response impairment in this parasitic disease.
authors.affiliation: Centro de Pesquisas Aggeu Magalhães, Fiocruz, Recife, PE, 50670-420, Brasil. silvia@cpqam.fiocruz.br
authors.forename: S M
authors.initials: SM
authors.lastname: Montenegro
authors.forename: F G
authors.initials: FG
authors.lastname: Abath
authors.forename: A L
authors.initials: AL
authors.lastname: Domingues
authors.forename: W
authors.initials: W
authors.lastname: Melo
authors.forename: C N
authors.initials: CN
authors.lastname: de Morais
authors.forename: E M
authors.initials: EM
authors.lastname: Coutinho
authors.forename: S
authors.initials: S
authors.lastname: Mahanty
authors.forename: T
authors.initials: T
authors.lastname: Wynn
mesh_terms: D019013:CD40 Antigens / Q000378:metabolism / Q000502:physiology*; D023201:CD40 Ligand / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000378:metabolism*; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism
chemical_list: D019013:CD40 Antigens; D023201:CD40 Ligand; D007371:Interferon-gamma