title: Detection of insecticide resistance in Aedes aegypti (Diptera: Culicidae) from Cuba and Venezuela.
abstract: Four strains of Aedes aegypti (L.), one from Cuba and three from Venezuela, were bioassayed for susceptibility to eight insecticides, including the organophosphates, temephos, malathion, fenthion, pirimiphos methyl, and chlorpyrifos, and the pyrethroids, deltamethrin, lambda cyhalothrin and cypermethrin, S, S, S,-tributyl phosphorotrithioate and piperonyl butoxide were used as synergists to assess the involvement of esterases and monooxygenases in organophosphate resistance. Venezuelan strains had low levels of resistance to fenthion and malathion, and moderate to high resistance to temephos, pyrimphos methyl, and chlorpiriphos. All strains were susceptible to the pyrethroids, except the Cuban strain, which had moderate levels of resistance to cypermethrin. Organophosphate resistance in Ae. aegypti is a serious threat to control operations. Integrated strategies for Ae. aegypti control to prevent or delay pyrethroid resistance in Venezuela and Cuba are discussed.
authors.affiliation: Departamento de Control de vectores, Instituto de Medicina Tropical Pedro Kouri Autopista Novia del Mediodía, Ciudad Habana, Cuba.
authors.forename: M M
authors.initials: MM
authors.lastname: Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: Bisset
authors.forename: D M
authors.initials: DM
authors.lastname: de Fernandez
authors.forename: L
authors.initials: L
authors.lastname: Lauzán
authors.forename: A
authors.initials: A
authors.lastname: Soca
mesh_terms: D000330:Aedes / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D000818:Animals; D003462:Cuba; D004950:Esterases / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics; D007305:Insecticide Resistance; D007306:Insecticides / Q000494:pharmacology*; D007928:Lethal Dose 50; D009946:Organothiophosphorus Compounds; D011722:Pyrethrins / Q000494:pharmacology*; D014687:Venezuela
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; D011722:Pyrethrins; D005982:Glutathione Transferase; D004950:Esterases