Hypoxia and oxidative stress. Tumour hypoxia--therapeutic considerations.
Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies.
Williams
K J
KJ
Department of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK.
Cowen
R L
RL
Stratford
I J
IJ
D001943:Breast Neoplasms / Q000378:metabolism / Q000628:therapy*; D015687:Cell Hypoxia / Q000235:genetics*; D005260:Female; D015316:Genetic Therapy; D006801:Humans; D018384:Oxidative Stress