title: Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).
abstract: The first reported synthesis of the DNA-PK inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035) is described. The structure of OK-1035 was validated by X-ray crystallography. An IC(50) value of 100 microM was determined for inhibition of DNA-PK, and this is approximately 12-fold higher than that reported previously.
authors.affiliation: Department of Chemistry, Bedson Building, The University, Newcastle upon Tyne NE1 7RU, UK.
authors.forename: M
authors.initials: M
authors.lastname: Stockley
authors.forename: W
authors.initials: W
authors.lastname: Clegg
authors.forename: G
authors.initials: G
authors.lastname: Fontana
authors.forename: B T
authors.initials: BT
authors.lastname: Golding
authors.forename: N
authors.initials: N
authors.lastname: Martin
authors.forename: L J
authors.initials: LJ
authors.lastname: Rigoreau
authors.forename: G C
authors.initials: GC
authors.lastname: Smith
authors.forename: R J
authors.initials: RJ
authors.lastname: Griffin
mesh_terms: D002867:Chromones / Q000494:pharmacology; D018360:Crystallography, X-Ray; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D009025:Morpholines / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D011728:Pyridones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C095985:3-cyano-5-(4-pyridyl)-6-hydrazonomethyl-2-pyridone; D002867:Chromones; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D006835:Hydrazones; D009025:Morpholines; D011728:Pyridones; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases