Interleukin-6 expression in exo-focal neurons after striatal cerebral ischemia.
Although anatomical and biochemical properties of the rat entopeduncular nucleus (EPN) closely resemble those of the substantia nigra pars reticulata (SNr), the present study shows that, unlike in the SNr, focal cerebral ischemia does not cause trans-synaptic degeneration of EPN neurons, despite striatal infarction and a similar delayed glial activation in both nuclei. In this study, interleukin-6 (IL-6) expression was found within EPN neurons 3 and 7 days after striatal ischemia. Since it has been reported that neuroprotective properties seem to predominate IL-6 function and that distinct SNr regions which demonstrate low trans-synaptic neuronal degeneration show high IL-6 expression and vice versa, IL-6 expression within partially deafferentiated but surviving EPN neurons could represent an intrinsic neuroprotective mechanism.
Dihné
M
M
Department of Neurology, RWTH Aachen, Pauwelsstr.30, D-52057 Aachen, Germany.
Peters
M
M
Block
F
F
D000818:Animals; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D001253:Astrocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D030161:Avian Proteins; D051926:Basigin; D001798:Blood Proteins; D002545:Brain Ischemia / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002452:Cell Count; D002470:Cell Survival / Q000276:immunology; D020392:Entopeduncular Nucleus / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005911:Gliosis / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D020244:Infarction, Middle Cerebral Artery / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D015850:Interleukin-6 / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D017628:Microglia / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D017072:Neostriatum / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009410:Nerve Degeneration / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009434:Neural Pathways / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; D001798:Blood Proteins; C102624:Bsg protein, Gallus gallus; C079432:Bsg protein, rat; D005904:Glial Fibrillary Acidic Protein; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D051926:Basigin