Aminophylline reversal of antihypertensive agent toxicity.
Hypotension occurred following a combined beta blocker (atenolol), angiotensin converting enzyme inhibitor (quinapil) and selective serotonin reuptake inhibitor (fluvoxamine) overdose. In another instance heart block and hypotension was noted in association with a diltiazem and atenolol adverse interaction. Crystalloid infusion was ineffective in both cases, but toxicity was rapidly reversed with aminophylline administration. Aminophylline's recognized inotropic and chronotropic properties make it a potentially valuable therapeutic agent in the treatment of antihypertensive medication toxicity.
Roberge
R J
RJ
Department of Emergency Medicine and the Internal Medicine Residency Program, St Francis Medical Center, Pittsburgh, PA 15202, USA.
Rossetti
M L
ML
Rosetti
J M
JM
D000319:Adrenergic beta-Antagonists / Q000506:poisoning*; D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000506:poisoning*; D001262:Atenolol / Q000506:poisoning*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D062787:Drug Overdose / Q000188:drug therapy*; D005260:Female; D016666:Fluvoxamine / Q000506:poisoning*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000188:drug therapy; D007546:Isoquinolines / Q000506:poisoning*; D008875:Middle Aged; D000077583:Quinapril; D017367:Selective Serotonin Reuptake Inhibitors / Q000506:poisoning*; D044005:Tetrahydroisoquinolines; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D000628:Aminophylline; D000806:Angiotensin-Converting Enzyme Inhibitors; D001262:Atenolol; D002316:Cardiotonic Agents; D016666:Fluvoxamine; D007546:Isoquinolines; D000077583:Quinapril; D017367:Selective Serotonin Reuptake Inhibitors; D044005:Tetrahydroisoquinolines