title: Relationship of vestibular aqueduct and inner ear pressure in Ménière's disease and the normal population.
abstract: OBJECTIVE
  Etiopathogenesis of Ménière's disease has not been resolved. The principal histopathologic finding in this disease is endolymphatic hydrops. The majority of radiologic and histopathologic studies demonstrated a narrow vestibular aqueduct in Ménière's disease. There is no study in the literature investigating the relationship between inner ear pressure and vestibular aqueduct dimensions. Static acoustic compliance is a noninvasive procedure that is thought to measure perilymphatic pressure at the footplate. An increase in mechanical fluid pressure in the inner ear is transmitted to the footplate of the stapes. This causes a reduction in the compliance at the drum. The aim of this study is to investigate the relationship between vestibular aqueduct dimensions and static acoustic compliance in Ménière's disease and the normal population.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Forty patients with Ménière's disease and 40 healthy individuals with no otolaryngologic disorders were the subjects of this study. Each group was further divided into two according to static compliance value (normal and low static compliance). In these four groups dimensions of vestibular aqueduct were determined radiologically by high-resolution computerized tomography and correlated with normal and low static acoustic compliance values (normal and high perilymphatic pressure).
  
  
  RESULTS
  The results demonstrated that vestibular aqueduct is narrower in patients with Ménière's disease than the normal population. However, there is no relationship between vestibular aqueduct dimensions and inner ear pressure obtained by static acoustic compliance measurements.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Hacettepe University Medical Faculty, Ankara, Turkey. lsennar@tr.net
authors.forename: L
authors.initials: L
authors.lastname: Sennaroglu
authors.forename: C
authors.initials: C
authors.lastname: Yilmazer
authors.forename: F
authors.initials: F
authors.lastname: Basaran
authors.forename: G
authors.initials: G
authors.lastname: Sennaroglu
authors.forename: B
authors.initials: B
authors.lastname: Gursel
mesh_terms: D000158:Acoustic Impedance Tests; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003187:Compliance; D007758:Ear, Inner / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D008875:Middle Aged; D010498:Perilymph / Q000502:physiology; D011312:Pressure; D011446:Prospective Studies; D013199:Stapes / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014723:Vestibular Aqueduct / Q000473:pathology* / Q000503:physiopathology*