title: [Sinusitis as a major cause of fever in intubated patients].
abstract: Because sinusitis is usually clinically silent in intubated patients, it is not widely appreciated as an important source of infection and fever in critically ill patients. Three such patients, two men aged 22 and 36 years, and a woman aged 50 years, suffered from respiratory insufficiency due to pneumonia. The course of the disease was determined by the sinusitis, which did not resolve during antibiotic therapy of the pneumonia, notwithstanding the fact that the causative micro-organism was susceptible to the antibiotics administered, and that both the tracheal and gastric tubes were led through the mouth instead of the nose. Flushing of the sinuses caused the fever to disappear and led to recovery of the patients. An aggressive approach to diagnose sinusitis in the intubated patient with fever in the intensive care unit is needed. A maxillary sinus lavage and culture, followed by treatment with specific antibiotics should be an integral part of the diagnosis and treatment in these patients. Surgery is indicated in the event of persistent sepsis.
authors.affiliation: Afd. Longziekten, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam. a.vonk@vumc.nl
authors.forename: A
authors.initials: A
authors.lastname: Vonk Noordegraaf
authors.forename: R R
authors.initials: RR
authors.lastname: de Bree
authors.forename: R J
authors.initials: RJ
authors.lastname: van Schijndel
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents; D003422:Critical Care; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000382:microbiology*; D006801:Humans; D007440:Intubation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D012121:Respiration, Artificial / Q000009:adverse effects; D012131:Respiratory Insufficiency / Q000209:etiology*; D012852:Sinusitis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000382:microbiology / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents