title: Urethral cytokine and immune responses in Chlamydia trachomatis-infected males.
abstract: Penile urethral swabs collected from PCR-confirmed Chlamydia trachomatis-infected, C. trachomatis-uninfected, and non-C. trachomatis-infected, nongonococcal urethritis-infected males were analyzed for cytokine, total immunoglobulin (Ig), and specific antibody levels by enzyme-linked immunosorbent assay. Differential cellular components of the swab transport medium were also enumerated for the same groups. Although low, the levels of C. trachomatis-specific IgA and IgG antibodies and interleukin 8 cytokine were significantly higher in C. trachomatis-infected individuals. There were no significant differences in the levels of seven additional cytokines evaluated.
authors.affiliation: Department of Microbiology, The University of Alabama at Birmingham, and Jefferson County Department of Health, Birmingham, Alabama 35294, USA. mspate@uab.edu
authors.forename: M S
authors.initials: MS
authors.lastname: Pate
authors.forename: S R
authors.initials: SR
authors.lastname: Hedges
authors.forename: D A
authors.initials: DA
authors.lastname: Sibley
authors.forename: M W
authors.initials: MW
authors.lastname: Russell
authors.forename: E W
authors.initials: EW
authors.lastname: Hook
authors.forename: J
authors.initials: J
authors.lastname: Mestecky
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D002690:Chlamydia Infections / Q000097:blood / Q000276:immunology* / Q000473:pathology; D002692:Chlamydia trachomatis / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000032:analysis*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014521:Urethra / Q000276:immunology* / Q000473:pathology; D014522:Urethral Diseases / Q000097:blood / Q000276:immunology* / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial; D016207:Cytokines; D007070:Immunoglobulin A; D007136:Immunoglobulins; D016209:Interleukin-8; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins