Adhesion signaling: how beta-catenin interacts with its partners.
The multi-functional protein beta-catenin plays essential roles in cell-cell adhesion and nuclear signaling. Elucidation of the structures of beta-catenin complexes is beginning to clarify how beta-catenin uses the same surface to bind its various partners, and provides insights into how these interactions might be regulated.
Gottardi
C J
CJ
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Gumbiner
B M
BM
D000818:Animals; D015820:Cadherins / Q000737:chemistry* / Q000378:metabolism; D051177:Catenins; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000378:metabolism; D024002:HMGB Proteins; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*; D051820:TCF Transcription Factors; D015534:Trans-Activators; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism; D051178:alpha Catenin; D051176:beta Catenin; D000095002:Delta Catenin
D015820:Cadherins; D051177:Catenins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D024002:HMGB Proteins; D010750:Phosphoproteins; D051820:TCF Transcription Factors; D015534:Trans-Activators; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors; D051178:alpha Catenin; D051176:beta Catenin; D000095002:Delta Catenin