High-level expression of NRAMP1 in peripheral blood cells and tuberculous granulomas from Mycobacterium bovis-infected bovines.
By Western blotting, we demonstrate high-level expression of NRAMP1 proteins in peripheral blood cells and granulomas of Mycobacterium bovis-infected bovines. Immunohistochemistry of granulomatous lesions showed heavily labeled epithelioid macrophages and Langhans cells. These data suggest that M. bovis infection enhances NRAMP1 expression and that active tuberculosis can occur despite this response.
Estrada-Chávez
C
C
Centro Nacional de Investigación Disciplinaria en Microbiología, INIFAP, Palo Alto, Mexico City, 05110, Mexico.
Pereira-Suárez
A L
AL
Meraz
M A
MA
Arriaga
C
C
García-Carrancá
A
A
Sánchez-Rodriguez
C
C
Mancilla
R
R
D000818:Animals; D002417:Cattle; D006099:Granuloma / Q000097:blood* / Q000276:immunology / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D009163:Mycobacterium bovis / Q000276:immunology*; D014380:Tuberculosis, Bovine / Q000097:blood* / Q000276:immunology / Q000473:pathology