title: Adsorptive behavior and electrochemical determination of the anti-fungal agent ketoconazole.
abstract: The adsorptive properties and electrochemical behavior of ketoconazole, an oral anti-fungal agent, are demonstrated at a glassy carbon electrode. The adsorption of the compound obeys the Frumkin isotherm with an interaction factor (alpha) of 0.985 and adsorptive coefficient (beta) of 1.98 x 10(6) L mol(-1). The Gibbs energy of adsorption (deltaG) is -3.59 x 10(4) J mol(-1) at 25 degrees C. A very sensitive electroanalytical method has been developed for determination of the drug with a detection limit of 4.0 x 10(-11) mol L(-1). Relationships between stripping current and concentration of ketoconazole were linear in the range 10(-6)-10(-10) mol L(-1) with different preconcentration periods. The method has been used to measure the ketoconazole content of tablets.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou, China. tzp@emb.zju.edu.cn
authors.forename: T Z
authors.initials: TZ
authors.lastname: Peng
authors.forename: Q
authors.initials: Q
authors.lastname: Cheng
authors.forename: C F
authors.initials: CF
authors.lastname: Yang
mesh_terms: D000327:Adsorption; D000935:Antifungal Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D002138:Calibration; D004563:Electrochemistry / Q000379:methods*; D007654:Ketoconazole / Q000032:analysis* / Q000097:blood / Q000652:urine; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012996:Solutions; D013607:Tablets / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D000935:Antifungal Agents; D012996:Solutions; D013607:Tablets; D007654:Ketoconazole