title: Burchellin: effects on Triatoma infestans and on Trypanosoma cruzi within this vector.
abstract: Supplementation of blood with the neolignan burchellin (50 microg/ml), a compound from the arboreous Lauraceae Aniba burchelli, affected the ingestion of blood and the course of excretion of fourth- and fifth-instar larvae of Triatoma infestans, the latter especially within the first 4 h after feeding. The total resultant weight loss of treated fourth instars within 24 and 48 h after feeding was only 24% and 28% vs 41% and 48%, respectively, in untreated bugs. In fifth instars, the total weight losses of untreated bugs within 24 and 48 h after feeding were 38% and 41% whereas the weight of treated bugs decreased by 28% and 34%, respectively. In a treatment of Trypanosoma cruzi-infected fourth instars, burchellin significantly reduced the population density of the established infection in the rectum at 5 and 10 days after feeding. This was especially due to a significant increase in the number of the main dividing stage, the epimastigote.
authors.affiliation: Department of Special Zoology, Ruhr-University, Bochum, Germany.
authors.forename: M M
authors.initials: MM
authors.lastname: Cabral
authors.forename: P
authors.initials: P
authors.lastname: Azambuja
authors.forename: O R
authors.initials: OR
authors.lastname: Gottlieb
authors.forename: T
authors.initials: T
authors.lastname: Kleffmann
authors.forename: E S
authors.initials: ES
authors.lastname: Garcia
authors.forename: G A
authors.initials: GA
authors.lastname: Schaub
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D014355:Chagas Disease / Q000469:parasitology; D005247:Feeding Behavior / Q000187:drug effects; D006790:Host-Parasite Interactions; D007303:Insect Vectors / Q000187:drug effects* / Q000469:parasitology*; D019770:Lauraceae / Q000737:chemistry; D051379:Mice; D011156:Population Density; D014224:Triatoma / Q000187:drug effects* / Q000469:parasitology*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
chemical_list: D001572:Benzofurans; C053585:burchellin