[Effect of alpha-tocopherol, tocopheryl quinone and other complexes with tocopherol-binding proteins on the activity of enzymes metabolizing arachidonic acid].
alpha-Tocopherol, tocopherylquinon jointly with the proteins tocopherol acceptors from cytosole were identified to inhibit the activity of 5-lipoxigenase and so the synthesis of leukotriene A4 at the early stages providing for A4 hydrolase activation and C4 synthesase, as well as accelerate leukotrienes B4 and C4 synthesis at the further stages respectively changing the final spectrum of leukotriens in the organism tissues. Firstly, the leading role of proteins complexes capable to strengthen the effect of alpha-tocopherol and tocopherylquinon on arachidonic acid oxidative metabolism was determined.
Parkhomets'
V P
VP
Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv.
Silonov
S B
SB
Donchenko
H V
HV
D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D016718:Arachidonic Acid / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017572:Leukotriene A4 / Q000096:biosynthesis; D016859:Lipoxygenase Inhibitors; D051381:Rats; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000737:chemistry / Q000494:pharmacology*
D002352:Carrier Proteins; D017572:Leukotriene A4; D016859:Lipoxygenase Inhibitors; C017763:alpha-tocopherol transfer protein; D014810:Vitamin E; D016718:Arachidonic Acid; C002421:tocopherylquinone; D001094:Arachidonate 5-Lipoxygenase; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases; C041116:leukotriene-C4 synthase; D024502:alpha-Tocopherol; C043134:leukotriene A4 hydrolase