title: Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties.
abstract: Ethylenediamine was reacted with suitable aromatic aldehydes in order to prepare their respective diSchiff bases. These compounds were then reduced to give the corresponding tetrahydrodiSchiff bases, which were low melting in nature. Finally, these derivatives were condensed with different aromatic aldehydes to give the desired tetrahydroimidazoles. The structures of all these compounds were established on the basis of spectral data. These novel tetrahydroimidazoles showed promising anti-inflammatory and analgesic activity. The compounds were also screened for their anti-bacterial property against Staphylococcus aureus and Escherichia coli.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, India. vibhasharma@worldnet.att.net
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: M S
authors.initials: MS
authors.lastname: Khan
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002351:Carrageenan / Q000037:antagonists & inhibitors; D004487:Edema / Q000139:chemically induced; D004926:Escherichia coli / Q000187:drug effects*; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D051379:Mice; D051381:Rats; D012545:Schiff Bases; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D007093:Imidazoles; C445525:N,N'-di-4-dimethylamino benzyl-2-(3,4-methlene dioxy phenyl)tetrahydroimidazole; C445523:N,N'-di-4-dimethylamino benzyl-2-(4-diethylamino phenyl)tetrahydroimidazole; D012545:Schiff Bases; D002351:Carrageenan