title: A yeast model for classical juvenile Batten disease (CLN3).
abstract: The gene involved in the classical juvenile form of Batten disease, CLN3 has been identified as being highly homologous to the Saccharomyces cerevisiae YHC3 gene. To provide a simple model for the biochemical events underlying this disease, several disruptions have been made in YHC3 in three different S. cerevisiae strains. No obvious growth differences were observed, and neither was the previously reported phenotypic difference between wild-type and yeast disrupted in YHC3.
authors.affiliation: Biochemistry Department, University of Otago, PO Box 56, Dunedin, New Zealand. karen@sanger.otago.ac.nz
authors.forename: K J
authors.initials: KJ
authors.lastname: Barwell
authors.forename: M F
authors.initials: MF
authors.lastname: Broom
mesh_terms: D016213:Cyclins / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics*; D017353:Gene Deletion; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics*; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D016213:Cyclins; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; C489809:YHC3 protein, S cerevisiae