Antibacterial agents (oxazolidinones, quinolones, macrolides and new agents): patent highlights June to December 2000.
Several patent disclosures were made on oxazolidinone, quinolone, macrolide and new antimicrobial agents between June and December 2000; 26 of these patents are discussed in this review. The exciting report on new oxazolidinone derivatives with potent activity against fastidious Gram-negative organisms is highlighted. Most of the new quinolones are structurally dissimilar to the traditional fluoroquinolones and demonstrate activity against Helicobacter pylori (MIC=0.013 microg/ml). New 14-membered macrolides with broad-spectrum activity including against Mycobacterium avium are also presented. A novel peptidic antibiotic with potent antimicrobial activity against Streptococcus pneumoniae (MIC<0.0005 microg/ml) is also highlighted.
Phillips
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Safat. dphillips@hsc.kuniv.edu.kw
Matowe
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WC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D018942:Macrolides; D010080:Oxazoles / Q000494:pharmacology*; D010330:Patents as Topic; D015363:Quinolones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D010080:Oxazoles; D015363:Quinolones