title: Circadian abnormalities in older adults.
abstract: This study examined the circadian phase adjustment of symptomatic elders ages 60-79 years in comparison with that of young, healthy adults ages 20-40 years. Seventy-two elders with complaints of insomnia or depression, and 30 young, healthy adults were assessed for 5-7 days at home. Sleep and illumination were recorded with Actillume wrist monitors and sleep diaries. Urine was collected over two 24-hr periods and assayed for 6-sulphatoxymelatonin (6-smt). The volunteers were then observed continuously for 5 nights and 4 days in the laboratory. In the laboratory, sleep periods were fixed at 8 hr with polysomnographic assessment of sleep, apnea-hypopnea, and nocturnal myoclonus. Circadian dispersion, defined as the mean variation of 6-smt acrophase from the median age-specific acrophase, was significantly greater in the older vs. young adults. Likewise, circadian malsynchronization, defined as the absolute number of hours (advance or delay) between the 6-smt acrophase and the middle of the sleep period, was significantly greater in the older vs. young volunteers. For the older volunteers, multiple regressions were calculated associating sleep with potential correlates of sleep disturbance. Nocturnal myoclonus and circadian malsynchronization were more strongly associated with sleep impairment than other factors (e.g., sleep apnea, depression). These observations suggest that circadian malsynchronization might be a common and significant cause of disturbed sleep among adults over age 60.
authors.affiliation: Department of Psychiatry, Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA 92093-0667, USA. syoungstedt@ucsd.edu
authors.forename: S D
authors.initials: SD
authors.lastname: Youngstedt
authors.forename: D F
authors.initials: DF
authors.lastname: Kripke
authors.forename: J A
authors.initials: JA
authors.lastname: Elliott
authors.forename: M R
authors.initials: MR
authors.lastname: Klauber
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D003866:Depressive Disorder / Q000503:physiopathology / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D008875:Middle Aged; D017286:Polysomnography; D020178:Sleep Disorders, Circadian Rhythm / Q000503:physiopathology* / Q000652:urine; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology / Q000652:urine
chemical_list: C054513:6-sulfatoxymelatonin; D008550:Melatonin