Spinal anaesthesia with ropivacaine 5 mg ml(-1) in glucose 10 mg ml(-1) or 50 mg ml(-1).
Forty patients undergoing spinal anaesthesia for a variety of surgical procedures were randomly allocated to receive 3 ml of ropivacaine 5 mg ml(-1) in glucose 10 mg ml(-1) or 50 mg ml(-1). Onset of sensory block to T10 was significantly faster (P=0.03) with the glucose 50 mg ml(-1) solution (median 5 min, range 2-20 min) than with the 10 mg ml(-1) solution (median 10 min, range 2-25 min). Maximum extent of cephalad spread was virtually the same in both groups (10 mg ml(-1) median T6/7, range T3-T10; 50 mg ml(-1) median T6, range T3-T10) with similar times to regression beyond S2 (10 mg ml(-1) median 210 min, range 150-330 min; 50 mg ml(-1) median 210 min, range 150-330 min). Complete motor block was produced in the majority of patients (10 mg ml(-1) 90%; 50 mg ml(-1) 85%) and the time to complete regression was the same in both groups (median 120 min, range 90-210 min). A block adequate for the projected surgery was achieved in all patients.
Whiteside
J B
JB
University Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee, UK.
Burke
D
D
Wildsmith
J A
JA
D000328:Adult; D000368:Aged; D000577:Amides / Q000008:administration & dosage* / Q000494:pharmacology; D000775:Anesthesia, Spinal / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000187:drug effects; D019999:Pharmaceutical Solutions; D000077212:Ropivacaine; D012677:Sensation / Q000187:drug effects; D016037:Single-Blind Method; D013046:Specific Gravity
D000577:Amides; D000779:Anesthetics, Local; D019999:Pharmaceutical Solutions; D000077212:Ropivacaine; D005947:Glucose