Rheumatoid neutrophilic dermatitis in a woman with seronegative rheumatoid arthritis.
Rheumatoid neutrophilic dermatitis (RND) is an unusual cutaneous reaction in patients with rheumatoid arthritis (RA). RND is characterized by symmetric, erythematous papules, plaques, nodules, and urticarial lesions often located over the joints, extensor surfaces of the extremities, or the trunk. This entity demonstrates an intense neutrophilic dermal infiltrate without vasculitis. All patients previously reported with RND had severe RA with relatively high titers of rheumatoid factor when tested. A 67-year-old woman had a 2-month history of multiple, tender, 4 to 8 mm erythematous, crusted papules and nodules that occurred in clusters on her anterior thighs, knees, and legs. She suffered from severe disabling seronegative RA. RND may complicate seronegative RA.
Brown
T S
TS
Department of Medicine, Division of Dermatology, University of Louisville, KY, USA.
Fearneyhough
P K
PK
Burruss
J B
JB
Callen
J P
JP
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D003872:Dermatitis / Q000276:immunology*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D009504:Neutrophils / Q000276:immunology; D012698:Serologic Tests