Molecular genetic analysis of diabetes in mice.
Transgenic and 'knockout' models are increasingly used to study the role of the immune system, insulin signaling and beta-cell gene transcription in diabetes. Mice and humans have similar genetics, developmental biology and physiology. In interpreting these models, however, one needs to be mindful of some differences that exist between mice and humans.
Gannon
M
M
Division of Diabetes and Endocrinology, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, USA. maureen.gannon@mcmail.vanderbilt.edu
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000235:genetics*; D004195:Disease Models, Animal; D006801:Humans; D007328:Insulin / Q000502:physiology; D007515:Islets of Langerhans / Q000503:physiopathology; D051379:Mice; D016688:Mice, Inbred NOD; D018345:Mice, Knockout; D008820:Mice, Obese; D008822:Mice, Transgenic; D008967:Molecular Biology; D013045:Species Specificity
D007328:Insulin