title: Acute oxalate nephropathy induced by star fruit in rats.
abstract: In this study, we intend to establish a connection between star fruit and acute oxalate nephropathy and also investigate predisposing factors for its development. Male Sprague-Dawley rats of 180 to 200 g were assigned to four groups; namely, control, experimental, fasting, and water-deprivation groups. The former two groups were subjected to both fasting and water deprivation, whereas the latter two groups were subjected to either fasting or water deprivation, respectively. Except for tap water for controls, the remaining groups were administered 4 mL/100 g of body weight of sour star fruit juice with an oxalate concentration of 2.46 g/dL. After these procedures, serial measurement of serum creatinine levels and kidney pathological examination were performed. Peak serum creatinine levels in the control, experimental, fasting, and water-deprivation groups were 0.50 +/- 0.04, 1.46 +/- 0.26, 0.68 +/- 0.20, and 0.52 +/- 0.08 mg/dL, respectively. The experimental group had a greater peak serum creatinine level (P < 0.05). Mean serum creatinine levels of the experimental group days 0, 1, 2, 3, 4, and 5 were 0.43 +/- 0.03, 1.11 +/- 0.18, 1.31 +/- 0.27, 1.16 +/- 0.28, 0.8 +/- 0.26, and 0.82 +/- 0.28 mg/dL, respectively. Mean serum creatinine levels days 1 to 3 were greater than that day 0 (P < 0.05). Pearson's correlation analysis of peak serum creatinine level and kidney weight for the experimental group showed a significant correlation (R = 0.75; P < 0.05; n = 9). In addition to typical changes of oxalate nephropathy, kidney pathological examination showed many refractile oxalate crystals with all rainbow colors under polarized light microscopy in the experimental group. In conclusion, sour star fruit with abundant oxalate contents could cause acute oxalate nephropathy in rats under the conditions of fasting and water deprivation.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Kaohsiung Veterans General Hospital, Taiwan.
authors.forename: H C
authors.initials: HC
authors.lastname: Fang
authors.forename: C L
authors.initials: CL
authors.lastname: Chen
authors.forename: J S
authors.initials: JS
authors.lastname: Wang
authors.forename: K J
authors.initials: KJ
authors.lastname: Chou
authors.forename: Y S
authors.initials: YS
authors.lastname: Chiou
authors.forename: P T
authors.initials: PT
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Yeh
authors.forename: M Y
authors.initials: MY
authors.lastname: Yeh
authors.forename: H M
authors.initials: HM
authors.lastname: Chung
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced*; D000818:Animals; D002129:Calcium Oxalate / Q000737:chemistry; D003404:Creatinine / Q000097:blood; D003460:Crystallization; D004326:Drinking; D005215:Fasting / Q000097:blood; D005638:Fruit / Q000009:adverse effects* / Q000737:chemistry; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size; D010070:Oxalates / Q000009:adverse effects* / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010070:Oxalates; D002129:Calcium Oxalate; D003404:Creatinine