title: Making a vertebrate limb: new players enter from the wings.
abstract: What initiates vertebrate limb development and induces limbs to form where they do? For several years the answer to this intriguing question has been framed in terms of a working model that limb induction depends on a dialogue between two members of the Fibroblast Growth Factor (FGF) family of intercellular signaling molecules, FGF8 and FGF10. Now, a recent paper has written roles for signals encoded by WNT genes, the vertebrate relatives of the Drosophila wingless gene, into the script.
authors.affiliation: Department of Anatomy, Box 0452, University of California, Rm. S-1457, 513 Parnassus Ave, San Francisco, CA 94143-0452, USA. gmaartin@itsa.ucsf.edu
authors.forename: G
authors.initials: G
authors.lastname: Martin
mesh_terms: D000818:Animals; D005121:Extremities / Q000196:embryology*; D051526:Fibroblast Growth Factor 10; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014714:Vertebrates / Q000196:embryology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D051526:Fibroblast Growth Factor 10; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors