[NF-kappa B as a therapeutic drug target].
The transcription factor NF-kappa B has attracted widespread interest based on its unusual regulation, the variety of stimuli that activate it, the diverse genes and biological responses that it controls, the striking evolutionary conservation of structure and function among family members, and its apparent involvement in a variety of human diseases. Recently NF-kappa B has been shown to be the target of new drug discovery. Here, we discuss the so-called NF-kappa B inhibitors and consider the development of new therapeutic agents.
Hishikawa
K
K
Department of Pharmacology, Teikyo University, School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. hisikawa@med.teikyo-u.ac.jp
Nakaki
T
T
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants; D001161:Arteriosclerosis / Q000188:drug therapy / Q000209:etiology; D002109:Caffeic Acids / Q000494:pharmacology / Q000627:therapeutic use; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015195:Drug Design; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use; D018014:Gene Transfer Techniques; D006801:Humans; D020672:I-kappa B Proteins; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology; D009154:Mutation; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D013256:Steroids
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D002109:Caffeic Acids; D004268:DNA-Binding Proteins; D005419:Flavonoids; D020672:I-kappa B Proteins; D007166:Immunosuppressive Agents; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D013256:Steroids; D000072000:NF-KappaB Inhibitor alpha; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol