Lipid formulations of polyene antifungal drugs and attenuation of associated nephrotoxicity.
Amphotericin B is an effective broad-spectrum antifungal agent, but various side effects, especially nephrotoxicity, have restricted its use. Recently, lipid formulations of amphotericin B have been developed in order to reduce its toxic side effects. Clinical trials, although in the early stages, suggest promising results, and that some of these lipid formulations are potent and less toxic, even at higher doses. We summarize herein the existing information about newer lipid formulations of polyene antifungal drugs, which could attenuate associated nephrotoxicity.
Razzaque
M S
MS
Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, Mass 02115, USA. mrazzaque@hms.harvard.edu
Hossain
M A
MA
Ahsan
N
N
Taguchi
T
T
D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D000935:Antifungal Agents / Q000009:adverse effects* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control; D008055:Lipids / Q000737:chemistry; D008081:Liposomes; D011090:Polyenes / Q000737:chemistry
D000935:Antifungal Agents; D008055:Lipids; D008081:Liposomes; D011090:Polyenes; D000666:Amphotericin B