Dynamical and structural properties of lipid membranes in relation to liposomal drug delivery systems.
The structural and dynamical properties of DPPC liposomes containing lipopolymers (PEG-lipids) and charged DPPS lipids have been studied in relation to the lipid membrane interaction of enzymes and peptides. The results suggest that both the lipid membrane structure and dynamics and in particular the appearance of small-scale lipid structures might be of importance for the activity of membrane associated and liposome degrading enzymes as well as for the membrane interaction of acylated peptides. The combined experimental and simulation results are of relevance for a rational development of peptide loaded liposomal drug delivery systems that become destabilized by membrane degrading phospholipase A(2) enzymes, which are found at elevated concentrations at diseased sites.
Jørgensen
K
K
Department of Chemistry, Building 207, Technical University of Denmark, DK-2800, Lyngby, Denmark.
Høyrup
P
P
Pedersen
T B
TB
Mouritsen
O G
OG
D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D008051:Lipid Bilayers / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D010741:Phospholipases A / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D013696:Temperature; D013997:Time Factors
D008051:Lipid Bilayers; D010455:Peptides; D011092:Polyethylene Glycols; D010741:Phospholipases A