Stress, norepinephrine and depression.
Stress is an important precipitant factor in depression, and the changes in various body systems that occur in depression are similar to those observed in response to stress. This paper discusses the interactions among the immune, endocrine and norepinephrine systems that are evident in patients with depression, as well as those affected by stress. Many of the stress-induced changes can be reversed by antidepressants, particularly norepinephrine reuptake inhibitors.
Leonard
B E
BE
Pharmacology Department, National University of Ireland, Galway, Ireland. belucg@iol.ie
D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D003866:Depressive Disorder / Q000503:physiopathology*; D006801:Humans; D008125:Locus Coeruleus / Q000503:physiopathology; D009638:Norepinephrine / Q000502:physiology*; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology
D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine