A new insight into mechanisms of age-related changes in heart rate.
Changes in cardiac rhythm induced by blockade of hyperpolarization currents with ZD 7288 depend on animal's age. The increase in cardiointerval duration is related to prolongation of T-P segment on ECG. It is hypothesized that the age-related changes in activity of hyperpolarization channels are determined by a modulating effect of the autonomic nervous system.
Zefirov
T L
TL
Department of Anatomy, Physiology, and Human Health Protection, Kazan State Pedagogical University.
Svyatova
N V
NV
Ziyatdinova
N I
NI
D000375:Aging / Q000502:physiology*; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats
D002316:Cardiotonic Agents; D007473:Ion Channels; D011743:Pyrimidines; C082246:ICI D2788