title: Testosterone delivery using glutamide-based complex high axial ratio microstructures.
abstract: Complex high axial ratio microstructures (CHARMs) were evaluated for delivery of testosterone in vivo. Methods to incorporate testosterone included noncovalent mixing and covalent attachment of testosterone to the lipid to form a prodrug monomer. When prepared by covalent attachment, testosterone-loaded CHARMs were resistant to in vitro spontaneous hydrolysis; when injected into rats, testosterone was released with biphasic kinetics consisting of a burst followed by a much slower phase. Some CHARM material associated with testosterone persisted at the site of injection for at least 9 days.
authors.affiliation: Departments of Chemistry and Biochemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Goldstein
authors.forename: J K
authors.initials: JK
authors.lastname: Amory
authors.forename: S M
authors.initials: SM
authors.lastname: Martin
authors.forename: C
authors.initials: C
authors.lastname: Vernon
authors.forename: A
authors.initials: A
authors.lastname: Matsumoto
authors.forename: P
authors.initials: P
authors.lastname: Yager
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005973:Glutamine / Q000031:analogs & derivatives / Q000737:chemistry; D007267:Injections; D008055:Lipids / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D008854:Microscopy, Electron; D011355:Prodrugs / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D013739:Testosterone / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D003692:Delayed-Action Preparations; D008055:Lipids; D011355:Prodrugs; D013501:Surface-Active Agents; D005973:Glutamine; D013739:Testosterone