title: Chromosome 12 and late-onset Alzheimer's disease.
abstract: Alzheimer's disease is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology. Using large extended families with multiple affected, we found that three markers on chromosome 12 were linked with late-onset Alzheimer's disease. These markers were downstream from the gene for alpha-2 macroglobulin. It is likely that multiple genes will be identified either as risk factors or as causative agents for late-onset Alzheimer's disease.
authors.affiliation: Division of Neurology, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, TX 79430, USA. neusep@ttuhsc.edu
authors.forename: S E
authors.initials: SE
authors.lastname: Poduslo
authors.forename: X
authors.initials: X
authors.lastname: Yin
mesh_terms: D017668:Age of Onset; D000544:Alzheimer Disease / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans
chemical_list: D005819:Genetic Markers