Synthesis and biological evaluation of novel bisindolylmaleimides that inhibit vascular endothelial cell proliferation.
A novel class of bisindolylmaleimides were synthesized and antiproliferative activities (HUVECs and three tumor cell lines) of these compounds were investigated. Two water-soluble derivatives, 10 and 12, possessing a dimethylaminoalkoxy side chain in their structure, showed interesting activity and selectivity on HUVECs proliferation.
Braña
M F
MF
Departamento de Química Orgánica y Farmacéutica, Facultad de CC. Experimentales y Técnicas, Universidad San Pablo CEU, Urb. Montepríncipe, Boadilla del Monte, 28668, Madrid, Spain. mfbrana@ceu.es
Añorbe
L
L
Tarrasón
G
G
Mitjans
F
F
Piulats
J
J
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008301:Maleimides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019311:Staurosporine / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014867:Water / Q000737:chemistry
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D007211:Indoles; D008301:Maleimides; D014867:Water; D019311:Staurosporine; C088060:bisindolylmaleimide