title: Systematic review of randomized clinical trials of surgical treatment for carpal tunnel syndrome.
abstract: BACKGROUND
  Carpal tunnel syndrome (CTS) is a common disorder for which several surgical treatment options are available. However, there is no consensus on the most effective method of treatment. The object of this systematic review is to compare the efficacy of the various surgical techniques in relieving the symptoms of CTS and promoting return to work and/or activities of daily living.
  
  
  METHODS
  Computer-aided searches of Medline, EMBASE and the Cochrane Controlled Trials Register were conducted, together with reference checking. A rating system, based on the number of studies and their methodological quality and findings, was used to determine the strength of the available evidence for the efficacy of the treatment.
  
  
  RESULTS
  Fourteen studies were included in the review. None of the alternatives to standard open carpal tunnel release (OCTR) seems to offer better relief of symptoms. There is conflicting evidence about whether endoscopic carpal tunnel release results in earlier return to work and/or activities of daily living.
  
  
  CONCLUSIONS
  Standard OCTR is still the preferred method of treatment for CTS. It is just as effective as the alternatives, but is technically less demanding, so incurs a lower risk of complications and of added costs.
authors.affiliation: Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands. aam.gerritsen.emgo@med.vu.nl
authors.forename: A A
authors.initials: AA
authors.lastname: Gerritsen
authors.forename: B M
authors.initials: BM
authors.lastname: Uitdehaag
authors.forename: D
authors.initials: D
authors.lastname: van Geldere
authors.forename: R J
authors.initials: RJ
authors.lastname: Scholten
authors.forename: H C
authors.initials: HC
authors.lastname: de Vet
authors.forename: L M
authors.initials: LM
authors.lastname: Bouter
mesh_terms: D002349:Carpal Tunnel Syndrome / Q000601:surgery*; D004724:Endoscopy / Q000379:methods / Q000592:standards; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology; D011787:Quality of Health Care; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity; D016896:Treatment Outcome