title: Intramedullary Ewing sarcoma of the spinal cord: consequences of molecular diagnostics. Case report.
abstract: Molecular biological techniques have begun to transform modern medicine. These techniques have shown promise in the pathological diagnosis of difficult or uncommon tumors. Accurate molecular diagnosis of the small round-cell tumors, for example, is especially important because divergent therapies may be required to eradicate such disparate lesions as neuroblastoma, lymphoma, rhabdomyosarcoma, central primitive neuroectodermal tumors/medulloblastoma, or Ewing sarcoma (ES). The authors present an unusual case of a primary, extraosseous ES arising from the intramedullary spinal cord, in which molecular studies were required for specific diagnosis and therapeutic guidance.
authors.affiliation: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1414, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Weil
authors.forename: Z
authors.initials: Z
authors.lastname: Zhuang
authors.forename: S
authors.initials: S
authors.lastname: Pack
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: L
authors.initials: L
authors.lastname: Helman
authors.forename: B G
authors.initials: BG
authors.lastname: Fuller
authors.forename: C L
authors.initials: CL
authors.lastname: Mackall
authors.forename: E H
authors.initials: EH
authors.lastname: Oldfield
mesh_terms: D000328:Adult; D020732:Cytogenetic Analysis; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012512:Sarcoma, Ewing / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery