title: Treatment of early stage squamous-cell carcinoma of the glottic larynx: endoscopic surgery or cricohyoidoepiglottopexy versus radiotherapy.
abstract: BACKGROUND
  Both surgery and radiotherapy are recognized treatments of T1-T2 squamous cell carcinoma of the larynx. We retrospectively analyze and compare the oncological outcome of patients treated in a single institution, either by endoscopic surgery or partial supracricoid laryngectomy versus radiation therapy.
  
  
  METHODS
  The medical records of 156 patients treated between 1983 and 1996 with either surgery (n = 75) or radiotherapy (n = 81) were reviewed. Male to female ratio, median age, and T-stage distribution were comparable.
  
  
  RESULTS
  With a median follow-up time of 59 months, the 5-year cause-specific survival rate of 93% was identical for both groups. The actuarial incidence of metachronous second primaries was 7% at 5 years. Local control at 5 years remained 84% after surgery and 77% after radiotherapy. Anterior commissure infiltration was shown to represent a negative predictive factor of local control for radiotherapy (p =.01). Salvage treatment brought ultimate local control to 96% of patients after surgery and 94% after radiation therapy with long-term laryngeal preservation rate altered significantly (p =.05) in the group of patients who received radiotherapy (90.1% vs 97.4%).
  
  
  CONCLUSIONS
  The treatment of laryngeal cancer is always a compromise between oncological efficiency and preservation of function. Our data suggest that, assuming proper selection of patients, radiation therapy and surgery yield similar local control and survival rates. The functional disadvantages after surgery are moderate and clearly counterbalanced by a significant decrease in long-term laryngeal preservation rate after radiotherapeutic treatment.
authors.affiliation: Department of ENT and Head and Neck Surgery, the Centre Hospitalier Universitaire Vaudois, av Bugnon 46, CH-1011, Lausanne, Switzerland.
authors.forename: L P
authors.initials: LP
authors.lastname: Bron
authors.forename: D
authors.initials: D
authors.lastname: Soldati
authors.forename: A
authors.initials: A
authors.lastname: Zouhair
authors.forename: M
authors.initials: M
authors.lastname: Ozsahin
authors.forename: E
authors.initials: E
authors.lastname: Brossard
authors.forename: P
authors.initials: P
authors.lastname: Monnier
authors.forename: P
authors.initials: P
authors.lastname: Pasche
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D004724:Endoscopy; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies