title: Genomic structure of three CLN3-like genes in Caenorhabditis elegans.
abstract: The genome of Caenorhabditis elegans is predicted to carry three genes similar to CLN3, the gene underlying juvenile neuronal ceroid lipofuscinosis. All three genes are transcribed and the genomic structure has been determined. The number and position of exons for two of the genes differ from that predicted from the genomic sequence, but no discrepancies with the genomic nucleotide sequence were found. Gene F07B10.1 (cln-3.1) is predicted to have 7 exons and to encode a protein of 424 amino acids. Gene C01G8.2 (cln-3.2) has 9 exons and encodes a protein of 435 amino acids. Gene ZC190.1 (cln-3.3) is predicted to have 9 exons and to encode a protein of 416 amino acids.
authors.affiliation: Department of Paediatrics and Child Health, University College London, UK.
authors.forename: W A
authors.initials: WA
authors.lastname: Mitchell
authors.forename: M
authors.initials: M
authors.lastname: Porter
authors.forename: P
authors.initials: P
authors.lastname: Kuwabara
authors.forename: S E
authors.initials: SE
authors.lastname: Mole
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D017931:DNA Primers; D008562:Membrane Glycoproteins; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: C105199:CLN3 protein, human; D017931:DNA Primers; D008562:Membrane Glycoproteins; D018832:Molecular Chaperones; D011506:Proteins