Inclusion body myositis associated with hepatitis C virus infection.
The case of a 77-year-old woman with hepatitis C virus infection with a 5-year history of muscle weakness and mild disturbance of gait is reported. Steroid therapy did not improve her symptoms. She developed HCV-related liver cirrhosis and hepatocellular carcinoma, and muscle biopsy revealed inclusion body myositis. Immunohistochemistry showed that the nonstructural region of HCV and 8-hydroxy-2'-deoxyguanosine, a marker of DNA damage by reactive oxygen species, were present in striated muscle cells of this patient.
Kase
S
S
Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan. kaseron@grape.med.tottori-u.ac.jp
Shiota
G
G
Fujii
Y
Y
Okamoto
K
K
Oyama
K
K
Nakano
T
T
Nomura
T
T
Suou
T
T
Nakashima
K
K
Ito
H
H
Kawasaki
H
H
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000821:virology; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000473:pathology*; D008103:Liver Cirrhosis / Q000821:virology; D008113:Liver Neoplasms / Q000821:virology; D009220:Myositis / Q000473:pathology* / Q000821:virology