title: A case of familial atrioventricular heart block affected by alteration of the autonomic nervous system.
abstract: Familial atrioventricular heart block affected by the autonomic nervous system has rarely been documented. We describe a 35-year-old man who had first-degree atrioventricular heart block with a PR interval of 0.46 s. He had a family history of 2 members with complete heart block and 1 with documented atrial standstill. The man's P-R interval was shortened by exercise and phenylephrine administration. In the electrophysiolgic study, a "split His" with an H-H' of 220 ms was recognized. Such a case of familial atrioventricular heart block with abnormal His-Purkinje conduction affected by the autonomic nervous system is very rare and worthy of description.
authors.affiliation: First Department of Medicine, Asahikawa Medical College, 2-1-1 Midorigaoka-Higashi, Asahikawa, 078-8510, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takehara
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamura
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Kakuchi
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001283:Atrioventricular Node / Q000187:drug effects* / Q000503:physiopathology; D001285:Atropine / Q000627:therapeutic use; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D015444:Exercise; D006327:Heart Block / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D010375:Pedigree; D010656:Phenylephrine / Q000627:therapeutic use; D013566:Sympathomimetics / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D013566:Sympathomimetics; D010656:Phenylephrine; D001285:Atropine