Effect of nutritional indoles on activity of xenobiotic metabolism enzymes and T-2 toxicity in rats.
Experiments on Wistar rats showed that feeding a ration containing 0.1% concentrate of food indoles (indole-3-carbinole and ascorbigen) for 3 weeks increased activity of phases I and II xenobiotic metabolism enzymes in the liver and intestinal mucosa and weakened the toxic effects of trichothecene T-2 mycotoxin. Activity of the key enzymes of T-2 detoxification, microsomal carboxylesterase and UDP-glucuronosyl transferase, was 1.5-2-fold higher in rats receiving T-2 toxin against the background of indole-enriched diet compared to toxin-treated rats kept on standard ration.
Kravchenko
L V
LV
Institute of Nutrition, Russian Academy of Medical Science, Moscow.
Avren'eva
L I
LI
Guseva
G V
GV
Posdnyakov
A L
AL
Tutel'yan
V A
VA
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004032:Diet; D007211:Indoles / Q000008:administration & dosage*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013605:T-2 Toxin / Q000633:toxicity*; D015262:Xenobiotics / Q000378:metabolism
D007211:Indoles; D015262:Xenobiotics; C053152:ascorbigen; D003577:Cytochrome P-450 Enzyme System; C016517:indole-3-carbinol; D013605:T-2 Toxin; D001205:Ascorbic Acid