5',6'-dehydroguiachrysine and 5',6'-dehydroguiaflavine, two curarizing quaternary indole alkaloids from the stem bark of Strychnos guianensis.
Two new quaternary indole alkaloids 5',6'-dehydroguiachrysine (1) and 5',6'-dehydroguiaflavine (2) were isolated from Strychnos guianensis stem bark. Their structures were determined by analysis of spectral data. Their inhibitory effects on neuromuscular transmission are also reported and compared to that of other quaternary alkaloids.
Penelle
J
J
Université de Liège, Institut de Pharmacie, Service de Pharmacognosie, CHU, Tour 4, Avenue de l'Hôpital 1, B 4000, Liège, Belgium. jacques.penelle@ulg.ac.be
Christen
P
P
Molgó
J
J
Tits
M
M
Brandt
V
V
Frédérich
M
M
Angenot
L
L
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification*; D029541:Loganiaceae / Q000737:chemistry*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry*; D013057:Spectrum Analysis
C442178:5',6'-dehydroguiachrysine; C442177:5',6'-dehydroguiaflavine; D000470:Alkaloids; D007211:Indoles