title: Resistance to multiple agent chemotherapy including cisplatin after chronic low-dose oral etoposide administration in gestational choriocarcinoma.
abstract: Most patients with gestational trophoblastic disease in whom single-agent or even combination chemotherapy has failed can be cured with salvage chemotherapy including etoposide or platinum-based regimens. Here we report a rare case of uterine choriocarcinoma following a molar evacuation that seemed to develop during chronic low-dose oral administration of etoposide for approximately 16 months. Although the patient was expected to have a good chance of cure using combination chemotherapy, the lesion was resistant to multiple-agent chemotherapy including cisplatin.
authors.affiliation: Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.forename: S
authors.initials: S
authors.lastname: Goto
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005047:Etoposide / Q000008:administration & dosage* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008099:Liver / Q000601:surgery; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D011247:Pregnancy; D012007:Rectum / Q000601:surgery; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D002945:Cisplatin