title: Cellular strategies for proteolytic targeting during migration and invasion.
abstract: Cell migration over or through the extracellular matrix (ECM) is an integral feature of both physiological and pathological processes. Regulation of the changing cell-ECM interactions involved can be effected by proteolysis and requires strict spatial and temporal targeting of proteinase activity. The versatile use of different proteinase systems, with a variety of localisation mechanisms and cleavage targets, is being revealed by a plethora of studies using in vitro models. This mini review reflects the status of our knowledge of strategies for the localisation of proteolytic activity effected during cell migration.
authors.affiliation: School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK. v.ellis@uea.ac.uk
authors.forename: V
authors.initials: V
authors.lastname: Ellis
authors.forename: G
authors.initials: G
authors.lastname: Murphy
mesh_terms: D000818:Animals; D002465:Cell Movement; D006868:Hydrolysis; D008666:Metalloendopeptidases / Q000378:metabolism
chemical_list: D008666:Metalloendopeptidases