title: Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients.
abstract: OBJECTIVE
  To describe the results of an ongoing radio-frequency (RF) ablation study in patients with hepatic metastases from colorectal carcinoma.
  
  
  METHODS
  In 117 patients, 179 metachronous colorectal carcinoma hepatic metastases (0.9-9.6 cm in diameter) were treated with RF ablation by using 17-gauge internally cooled electrodes. Computed tomographic follow-up was performed every 4-6 months. Recurrent tumors were retreated when feasible. Time to new metastases and death for each patient and time to local recurrence for individual lesions were modeled with Kaplan-Meier analysis. Modeling determined the effect of number of metastases on the time to new metastases and death and effect of tumor size on local recurrence.
  
  
  RESULTS
  Estimated median survival was 36 months (95% CI; 28, 52 months). Estimated 1, 2, and 3-year survival rates were 93%, 69%, and 46%, respectively. Survival was not significantly related to number of metastases treated. In 77 (66%) of 117 patients, new metastases were observed at follow-up. Estimated median time until new metastases was 12 months (95% CI; 10, 18 months). Percentages of patients with no new metastases after initial treatment at 1 and 2 years were 49% and 35%, respectively. Time to new metastases was not significantly related to number of metastases. Seventy (39%) of 179 lesions developed local recurrence after treatment. Of these, 54 were observed by 6 months and 67 by 1 year. No local recurrence was observed after 18 months. Frequency and time to local recurrence were related to lesion size (P < or =.001).
  
  
  CONCLUSIONS
  RF ablation is an effective method to treat hepatic metastases from colorectal carcinoma.
authors.affiliation: Department of Radiology, Ospedale Generale, Busto Arsizio, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Solbiati
authors.forename: T
authors.initials: T
authors.lastname: Livraghi
authors.forename: S N
authors.initials: SN
authors.lastname: Goldberg
authors.forename: T
authors.initials: T
authors.lastname: Ierace
authors.forename: F
authors.initials: F
authors.lastname: Meloni
authors.forename: M
authors.initials: M
authors.lastname: Dellanoce
authors.forename: L
authors.initials: L
authors.lastname: Cova
authors.forename: E F
authors.initials: EF
authors.lastname: Halpern
authors.forename: G S
authors.initials: GS
authors.lastname: Gazelle
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D004598:Electrosurgery / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D013997:Time Factors