title: Response of preschool children with asthma symptoms to fluticasone propionate.
abstract: BACKGROUND
  Many uncertainties remain in the diagnosis and treatment of preschool children with asthma symptoms.
  
  
  OBJECTIVE
  We sought to determine the subgroups of preschool children (aged 12-47 months) with recurrent asthma symptoms most likely to respond to inhaled fluticasone propionate (200 microg/d).
  
  
  METHODS
  Subgroups of pooled data from 2 similar 12-week multicenter studies were analyzed.
  
  
  RESULTS
  Children with frequent symptoms (symptoms on > or =3 days per week and a total of > or =75% days with symptoms during the 4-week run-in period; n = 169) showed a significantly greater increase in days without symptoms after fluticasone propionate treatment (0% to 45%) compared with after placebo treatment (0% to 25%, P =.005). Children with a family history of asthma (n = 213) also had a significantly greater increase in days without symptoms after fluticasone propionate (11% to 54%) compared with after placebo (7% to 35%, P =.002) and a significantly higher proportion of exacerbation-free patients (61% to 76%, P =.02). Children with less frequent symptoms, no family history of asthma, or both showed no significant treatment effect. There seemed to be no association between response to fluticasone propionate and history of rhinitis or eczema or the number of previous exacerbations.
  
  
  CONCLUSIONS
  Children with frequent symptoms, a family history of asthma, or both showed the greatest response to fluticasone propionate treatment. These findings may help to predict treatment outcome and guide the management of preschool children with recurrent asthma symptoms.
authors.affiliation: Department of Pediatrics, Isala Klinieken, De Weezenlanden Hospital, Zwolle, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Roorda
authors.forename: G
authors.initials: G
authors.lastname: Mezei
authors.forename: H
authors.initials: H
authors.lastname: Bisgaard
authors.forename: C
authors.initials: C
authors.lastname: Maden
mesh_terms: D000280:Administration, Inhalation; D000367:Age Factors; D000730:Androstadienes / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002675:Child, Preschool; D004311:Double-Blind Method; D004485:Eczema; D005191:Family Characteristics; D005260:Female; D000068298:Fluticasone; D006801:Humans; D007223:Infant; D008297:Male; D009330:Nebulizers and Vaporizers; D010919:Placebos; D012135:Respiratory Sounds; D012220:Rhinitis
chemical_list: D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D010919:Placebos; D000068298:Fluticasone