title: Early effects of cis-dichlorodiammine platinum (II) on tumor progression and programmed death of Ehrlich ascites carcinoma cells.
abstract: We studied the effects of cis-dichlorodiammine platinum (II) on different pathways of cell death in cultured Ehrlich ascites carcinoma in vitro and on subsequent growth of transplanted tumor in vivo. One-hour incubation with the cytostatic modulated apoptosis in cell culture. However, exposure of cell culture to a minimal effective concentration of cis-platinum(II)diammine dichloride promoted the growth of transplanted tumor.
authors.affiliation: International Research Center for Extreme Body States, Presidium of the Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences. inscience@mail.ru
authors.forename: B V
authors.initials: BV
authors.lastname: Razin
authors.forename: E V
authors.initials: EV
authors.lastname: Inzhevatkin
authors.forename: V V
authors.initials: VV
authors.lastname: Nefedova
authors.forename: A B
authors.initials: AB
authors.lastname: Egorova
authors.forename: V I
authors.initials: VI
authors.lastname: Kazbanov
authors.forename: V P
authors.initials: VP
authors.lastname: Nefedov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D051379:Mice; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin