Bioactive acridone alkaloids from Swinglea glutinosa.
A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.
Weniger
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B
UMR 7081, Faculté de Pharmacie, Université Louis Pasteur Strasbourg, BP 24, 67401 Illkirch Cedex, France. weninger@pharma.u-strasbg.fr
Um
B H
BH
Valentin
A
A
Estrada
A
A
Lobstein
A
A
Anton
R
R
Maillé
M
M
Sauvain
M
M
D000166:Acridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D003105:Colombia; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D004912:Erythrocytes; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D009549:Nigeria; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D027821:Rutaceae / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000166:Acridines; D000470:Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D002738:Chloroquine