title: Genome-wide scan for Parkinson's disease: the GenePD Study.
abstract: A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
authors.affiliation: Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: DeStefano
authors.forename: L I
authors.initials: LI
authors.lastname: Golbe
authors.forename: M H
authors.initials: MH
authors.lastname: Mark
authors.forename: A M
authors.initials: AM
authors.lastname: Lazzarini
authors.forename: N E
authors.initials: NE
authors.lastname: Maher
authors.forename: M
authors.initials: M
authors.lastname: Saint-Hilaire
authors.forename: R G
authors.initials: RG
authors.lastname: Feldman
authors.forename: M
authors.initials: M
authors.lastname: Guttman
authors.forename: R L
authors.initials: RL
authors.lastname: Watts
authors.forename: O
authors.initials: O
authors.lastname: Suchowersky
authors.forename: A L
authors.initials: AL
authors.lastname: Lafontaine
authors.forename: N
authors.initials: N
authors.lastname: Labelle
authors.forename: M F
authors.initials: MF
authors.lastname: Lew
authors.forename: C H
authors.initials: CH
authors.lastname: Waters
authors.forename: J H
authors.initials: JH
authors.lastname: Growdon
authors.forename: C
authors.initials: C
authors.lastname: Singer
authors.forename: L J
authors.initials: LJ
authors.lastname: Currie
authors.forename: G F
authors.initials: GF
authors.lastname: Wooten
authors.forename: P
authors.initials: P
authors.lastname: Vieregge
authors.forename: P P
authors.initials: PP
authors.lastname: Pramstaller
authors.forename: C
authors.initials: C
authors.lastname: Klein
authors.forename: J P
authors.initials: JP
authors.lastname: Hubble
authors.forename: M
authors.initials: M
authors.lastname: Stacy
authors.forename: E
authors.initials: E
authors.lastname: Montgomery
authors.forename: M E
authors.initials: ME
authors.lastname: MacDonald
authors.forename: J F
authors.initials: JF
authors.lastname: Gusella
authors.forename: R H
authors.initials: RH
authors.lastname: Myers
mesh_terms: D000368:Aged; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002885:Chromosomes, Human, Pair 16; D002899:Chromosomes, Human, Pair 9; D004299:Dopamine beta-Hydroxylase / Q000235:genetics; D004422:Dystonia Musculorum Deformans / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D004299:Dopamine beta-Hydroxylase