Conditioned reinstatement of drug-seeking behavior with a discrete compound stimulus classically conditioned with intravenous cocaine.
The present study investigated the ability of a light and tone (LT) compound stimulus paired with cocaine infusions to reinstate cocaine-seeking behavior. Rats were trained to self-administer cocaine in the presence or absence of the LT during daily 3-hr sessions (maintenance). During Maintenance Days 5 and 10, rats underwent classical conditioning, whereby passive cocaine infusions were paired with either short-delayed, random, or no presentations of an LT. After extinction sessions, rats underwent test sessions in which the LT was presented in a noncontingent or response-contingent manner to measure conditioned cocaine-seeking behavior. The results demonstrated that response-contingent LT presentations significantly increased cocaine-seeking behavior and that the LT trained in a classical conditioning format transferred to an operant secondary reinforcer.
Kruzich
P J
PJ
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston 29425, USA.
Congleton
K M
KM
See
R E
RE
D000818:Animals; D001245:Association Learning; D019970:Cocaine-Related Disorders / Q000523:psychology*; D003214:Conditioning, Classical; D003216:Conditioning, Operant; D005108:Extinction, Psychological; D008297:Male; D011939:Mental Recall; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration / Q000523:psychology; D015819:Substance Abuse, Intravenous / Q000523:psychology*; D014163:Transfer, Psychology