title: Total synthesis of (-)-callystatin A.
abstract: [reaction: see text] The enantioselective synthesis of callystatin A is described. The pivotal step in the synthesis is the stereoselective aldol reaction that generates the beta-hydroxy ketone moiety. Utilizing the allylic strain within the ethyl ketone precursor, we were able to generate the all-syn configuration of callystatin A. For the construction of the two diene moieties, both a Heck coupling and a Wittig reaction were employed.
authors.affiliation: Institut für Organische Chemie, Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany. kalesse@mbox.oci.uni-hannover.de
authors.forename: M
authors.initials: M
authors.lastname: Kalesse
authors.forename: M
authors.initials: M
authors.lastname: Quitschalle
authors.forename: C P
authors.initials: CP
authors.lastname: Khandavalli
authors.forename: A
authors.initials: A
authors.lastname: Saeed
mesh_terms: D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry
chemical_list: D005231:Fatty Acids, Unsaturated; C421091:callystatin A