The membrane-disrupting activity of alpha-aminoalkanephosphonic acids and their derivatives.
The influence of a series of acyclic and cyclic aminophosphonates on the physicochemical properties of model (planar lipid membranes-BLM) and biological (erythrocytes-RBC) membranes was studied. The results obtained were compared with the results of physiological tests performed on the aquatic plant Spirodela oligorrhiza. It was found that the inhibition of plant growth by the compounds studied correlated, although not very highly, with the observed changes in the properties of membranes used. It was also found that both the biological activity of aminophosphonates and their efficiency at modifying the physicochemical parameters of membranes depended on their structural features.
Deron
A
A
Department of Organic Chemistry, Biochemistry and Biotechnology, Wrocław University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
Dziamska
A
A
Pawlaczyk
I
I
Bielecki
K
K
Kleszczyńska
H
H
Gancarz
R
R
Sarapuk
J
J
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D063065:Organophosphonates / Q000737:chemistry*; D010944:Plants / Q000187:drug effects; D013053:Spectrophotometry; D013329:Structure-Activity Relationship; D013552:Swine; D013997:Time Factors
D063065:Organophosphonates