Genome-wide scan for Parkinson's disease: the GenePD Study.
A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine beta-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
DeStefano
A L
AL
Department of Neurology, Boston University Schools of Medicine and of Public Health, Boston, MA 02118, USA.
Golbe
L I
LI
Mark
M H
MH
Lazzarini
A M
AM
Maher
N E
NE
Saint-Hilaire
M
M
Feldman
R G
RG
Guttman
M
M
Watts
R L
RL
Suchowersky
O
O
Lafontaine
A L
AL
Labelle
N
N
Lew
M F
MF
Waters
C H
CH
Growdon
J H
JH
Singer
C
C
Currie
L J
LJ
Wooten
G F
GF
Vieregge
P
P
Pramstaller
P P
PP
Klein
C
C
Hubble
J P
JP
Stacy
M
M
Montgomery
E
E
MacDonald
M E
ME
Gusella
J F
JF
Myers
R H
RH
D000368:Aged; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002885:Chromosomes, Human, Pair 16; D002899:Chromosomes, Human, Pair 9; D004299:Dopamine beta-Hydroxylase / Q000235:genetics; D004422:Dystonia Musculorum Deformans / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*
D005819:Genetic Markers; D004299:Dopamine beta-Hydroxylase