title: Inflammatory myofibroblastic tumor with CNS involvement.
abstract: BACKGROUND
  Inflammatory myofibroblastic tumors (IMT) represent a spectrum of neoplasms that occur in the mesentery and retroperitoneum and less frequently in the mediastinum of children and young adults. Transformation into inflammatory fibrosarcoma and metastases are rare.
  
  
  METHODS
  We report the case of a 16-year-old patient with an inflammatory myofibroblastic tumor of the mesentery with mediastinal metastases. Partial remission was obtained by chemotherapy with ifosfamide, dactinomycine, and vincristine. Two months later, relapse with infiltration of the meninges developed, and the patient died.
  
  
  CONCLUSIONS
  This case demonstrates unusual features of an IMT: presentation with metastases, excellent response to chemotherapy, dissemination to the CNS.
authors.affiliation: Division of Oncology, Department of Internal Medicine, University Hospital Zurich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Trojan
authors.forename: T
authors.initials: T
authors.lastname: Stallmach
authors.forename: S
authors.initials: S
authors.lastname: Kollias
authors.forename: B C
authors.initials: BC
authors.lastname: Pestalozzi
mesh_terms: D000293:Adolescent; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008578:Meninges / Q000473:pathology; D008643:Mesentery / Q000473:pathology; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D014057:Tomography, X-Ray Computed