title: Cancer chemopreventive activity of phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, from Polygonum lapathifolium.
abstract: To search for cancer chemopreventive agents from natural resources, many phytochemicals have been screened using the in vitro synergistic assay indicated by the inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA). Two phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, were isolated from the aerial part of Polygonum lapathifolium as inhibitors on the EBV-EA induction. These compounds also exhibited significant anti-tumor-promoting effects on mouse two-stage skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA, as an initiator) and TPA as a promoter. Further, vanicoside B exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors initiated with an NO donor, NOR-1.
authors.affiliation: Kyoto Pharmaceutical University, Yamashina-ku, 607-8414, Kyoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takasaki
authors.forename: T
authors.initials: T
authors.lastname: Konoshima
authors.forename: S
authors.initials: S
authors.lastname: Kuroki
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Nishino
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002934:Cinnamates / Q000494:pharmacology*; D004187:Disaccharides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004952:Esters / Q000737:chemistry*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D008956:Models, Chemical; D009369:Neoplasms / Q000517:prevention & control*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D013395:Sucrose / Q000737:chemistry; D013755:Tetradecanoylphorbol Acetate / Q000378:metabolism; D013997:Time Factors
chemical_list: D016588:Anticarcinogenic Agents; D002934:Cinnamates; D004187:Disaccharides; D004952:Esters; D020030:Nitric Oxide Donors; C440098:lapathoside A; C087106:vanicoside B; D013395:Sucrose; D013755:Tetradecanoylphorbol Acetate