Urethane N-carboxyanhydrides from beta-amino acids.
A general method has been developed for the synthesis of N-tert-butyloxycarbonyl N-carboxyanhydrides from beta-amino acids using Vilsmeier complex. These beta-UNCA are stable, and the reactivity with different nucleophiles (alcohol, amine, lithium enolate) was studied.
McKiernan
M
M
UMR 5810-CNRS, LAPP Universités Montpellier I et II, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
Huck
J
J
Fehrentz
J A
JA
Roumestant
M L
ML
Viallefont
P
P
Martinez
J
J