Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia.
Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disease triggered by several anaesthetic agents. The in vitro muscle contracture test (IVCT) is the standard test to establish an individual's risk of susceptibility to MH. Clinical practitioners and geneticists of the European MH Group have agreed on the present guidelines for the detection of MH susceptibility using molecular genetic techniques and/or IVCT to predict the risk of MH.
Urwyler
A
A
Department of Anaesthesia and Research, Kantonsspital, University of Basel, Switzerland.
Deufel
T
T
McCarthy
T
T
West
S
S
D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008305:Malignant Hyperthermia / Q000175:diagnosis* / Q000235:genetics; D009119:Muscle Contraction; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics
D019837:Ryanodine Receptor Calcium Release Channel