Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4(+)-T-cell subsets are determined only by coreceptor expression.
In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.
Kwa
D
D
Department of Clinical Viro-Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Vingerhoed
J
J
Boeser-Nunnink
B
B
Broersen
S
S
Schuitemaker
H
H
D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000472:pathogenicity*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D019713:Receptors, CCR5 / Q000032:analysis*; D019718:Receptors, CXCR4 / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000821:virology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000032:analysis
D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D017493:Leukocyte Common Antigens; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1