title: High prevalence of coeliac disease in a population-based study from Western Australia: a case for screening?
abstract: OBJECTIVE
  To determine the prevalence of coeliac disease in an Australian rural community.
  
  
  METHODS
  Retrospective analysis of stored serum samples from 3,011 random subjects from the Busselton Health Study. IgA antiendomysial antibodies (AEA) were detected by indirect immunofluorescence, and subjects testing positive were contacted and offered small-bowel biopsy.
  
  
  METHODS
  Prevalence of AEA positivity and biopsy-proven coeliac disease in the community with reference to the proportion of symptomatic to asymptomatic patients.
  
  
  RESULTS
  10 of 3,011 subjects were AEA positive. One subject had died, one subject could not be traced and one refused small-bowel biopsy. All subjects with detectable AEA who consented to biopsy had pathological changes consistent with coeliac disease. The prevalence of newly diagnosed biopsyproven coeliac disease is 7 in 3,011 (1 in 430). Two further subjects had a diagnosis of coeliac disease before this study. When all AEA-positive patients and those previously diagnosed are included, the prevalence is 12/3,011 (1 in 251). There was a significant clustering of cases in the 30-50-years age range, with 10/12 (83%; 95% CI, 52%-98%) aged between 30 and 50 years, compared with 1,092/3,011 (36%; 95% CI, 35%-38%) of the total population (P<0.03). Of the eight AEA-positive subjects who could be contacted, four had symptoms consistent with coeliac disease and four were asymptomatic. Three subjects were iron-deficient, four subjects had first-degree relatives with coeliac disease and one subject had type 1 diabetes mellitus.
  
  
  CONCLUSIONS
  The prevalence of coeliac disease is high in a rural Australian community. Most patients are undiagnosed, and asymptomatic.
authors.affiliation: Fremantle Hospital, WA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Hovell
authors.forename: J A
authors.initials: JA
authors.lastname: Collett
authors.forename: G
authors.initials: G
authors.lastname: Vautier
authors.forename: A J
authors.initials: AJ
authors.lastname: Cheng
authors.forename: E
authors.initials: E
authors.lastname: Sutanto
authors.forename: D F
authors.initials: DF
authors.lastname: Mallon
authors.forename: J K
authors.initials: JK
authors.lastname: Olynyk
authors.forename: D J
authors.initials: DJ
authors.lastname: Cullen
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D002446:Celiac Disease / Q000097:blood / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012424:Rural Population; D014904:Western Australia / Q000453:epidemiology