[Use of mirtilene forte and adrusen zinco for correction of oxidative lesions in mitochondria in rats OXYS with inherited hyperproduction of free radicals].
A long-term uptake of a diet supplemented with Mirtilene Forte (Vaccinum myrtillus extract) or Adrusen Zinco (a vitamin E complex with zinc, copper, selenium and omega-3 polyunsturated fatty acid) improved the functional state of liver mitochondria in OXYS rat strain. Adrusen Zinco sharply decreases the level of protein and lipid oxidation products. Possible mechanisms of the drug action are considered in relationship with their antioxidant properties.
Shabalina
I G
IG
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, pr. akad. Lavrent'eva, 10, Novosibirsk, 630090 Russia.
Shalbueva
N I
NI
Dikalova
A E
AE
Sinitsyna
O I
OI
Krysanova
Zh S
ZhS
Kolosova
N G
NG
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology; D004338:Drug Combinations; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism; D008297:Male; D008670:Metals / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D010766:Phosphorylation; D028321:Plant Preparations / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000494:pharmacology; D029796:Vaccinium; D014810:Vitamin E / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology
D000975:Antioxidants; D004338:Drug Combinations; D015525:Fatty Acids, Omega-3; D005609:Free Radicals; D008670:Metals; D028321:Plant Preparations; D014810:Vitamin E; D003300:Copper; D012643:Selenium; D015032:Zinc