Prevention of ventricular fibrillation during acute myocardial ischemia: control of free fatty acids.
Fatal ventricular fibrillation is a common complication of acute coronary syndromes. Effective preventive measures are not available. Immediate restriction of free fatty acid availability should optimize ischemic myocardial metabolism, reduce ventricular vulnerability, and increase glucose utilization. Rapid inhibition of lipoprotein lipase activity will achieve this. The clinical effects of antilipolytic treatment require further study.
Oliver
M F
MF
Cardiology, University of Edinburgh, Scotland.
D000208:Acute Disease; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications / Q000378:metabolism*; D014693:Ventricular Fibrillation / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control*
D005230:Fatty Acids, Nonesterified