title: Health-related quality of life with coronary heart disease prevention and treatment.
abstract: Estimating the net benefits of dyslipidemia treatment is limited by the lack of comprehensive and standardized information on the preference for dyslipidemia and coronary heart disease. In a hospital-based study, we measured the health-related quality of life (HRQOL) of healthy participants without dyslipidemia (n = 307) and with dyslipidemia (n = 251) and patients with coronary heart disease (n = 320). Compared to the healthy participants without dyslipidemia, those with dyslipidemia reported lower adjusted mean scores on the Rating Scale (-2.8 points, P = 0.02) and the SF-36 General Health Scale (-3.3 points, P = 0.02). No differences were observed on the Time Trade-off and the Standard Gamble Scales. Coronary patients reported lower scores on all preference scales and most SF-36 scales. The causes of the small but real reduction in HRQOL reported by dyslipidemic individuals should be identified in order to optimize the net benefits of lipid therapy.
authors.affiliation: Division of Clinical Epidemiology, The Montreal General Hospital, Montreal, Quebec, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Lalonde
authors.forename: A E
authors.initials: AE
authors.lastname: Clarke
authors.forename: L
authors.initials: L
authors.lastname: Joseph
authors.forename: T
authors.initials: T
authors.lastname: Mackenzie
authors.forename: S A
authors.initials: SA
authors.lastname: Grover
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000150:complications / Q000517:prevention & control* / Q000523:psychology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000517:prevention & control* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011788:Quality of Life; D011792:Quebec