Primary effusion lymphoma with herpesvirus 8 DNA in patients coinfected with HIV and hepatitis C virus: a report of 2 cases.
The primary effusion lymphoma (PEL), commonly described in patients with AIDS, is a unique subset of diffuse large cell lymphoma in which the malignant lymphocytes proliferate exclusively in serous cavities. The cytologic, immunophenotypic, and molecular features of PEL are presented from findings of 2 patients coinfected with HIV and hepatitis C virus who presented with abdominal pain. Abdominal radiography in both patients displayed marked peritoneal effusions. Cytomorphologic examination of peritoneal fluid revealed a malignant lymphoma in both. Their immunophenotypic expression was CD30 (Ki-1) and epithelial membrane antigen. Molecular analysis demonstrated human herpesvirus 8 DNA in both patients and bcl-2 oncogene rearrangement within the major breakpoint region of t(14;18) chromosome translocation in Case B only. Clinical correlation supports the current concept that PEL represents a primary HIV/AIDS-related lymphoma in effusion. Cytomorphologic examination of body cavity fluid serves as a tool for the initial diagnosis of PEL.
Hong
S
S
Department of Pathology, College of Medicine, Howard University Hospital, Washington, DC, USA.
Krafft
A E
AE
D000328:Adult; D001202:Ascitic Fluid / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000821:virology*; D006526:Hepatitis C / Q000150:complications / Q000821:virology*; D006566:Herpesviridae Infections / Q000150:complications / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000145:classification / Q000235:genetics / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D016483:Lymphoma, AIDS-Related / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged
D004279:DNA, Viral