Effects of dexamethasone and FK506 on Helicobacter pylori-induced gastritis and bacterial viability in Mongolian gerbils.
FK506 and dexamethasone were used to investigate whether or not immunosuppression affects H. pylori colonization and gastric mucosal damage induced by Helicobacter pylori in Mongolian gerbils. Two weeks after H. pylori infection, FK506 and dexamethasone or vehicle alone were subcutaneously administered once daily for the following 2 weeks. FK506 or vehicle alone was administered subcutaneously once daily for 5 weeks (1 week before and 4 weeks after infection). In H. pylori-infected animals for 4 weeks, hemorrhagic erosions and inflammatory responses (neutrophil infiltration and lymphoid follicle formation) were induced in gastric mucosa at an incidence of 100%. Both FK506 and dexamethasone administered for 2 weeks markedly reduced such mucosal changes. In these animals, H. pylori viability in the stomach was significantly elevated. FK506 administered for 5 weeks also significantly inhibited the hemorrhagic erosions, edema and neutrophil infiltration in the stomach. H. pylori viability was slightly elevated as compared with the control. It was concluded that the host immune responses might play dual roles both by deteriorating gastritis induced by H. pylori and by protecting against H. pylori infection in its early stage.
Naka
Y
Y
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan. qvm99045@poppy.kyoto-phu.ac.jp
Aihara
T
T
Keto
Y
Y
Okabe
S
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D015169:Colony Count, Microbial; D003907:Dexamethasone / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology; D005849:Gerbillinae; D005938:Glucocorticoids / Q000494:pharmacology*; D016481:Helicobacter Infections / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008221:Lymphoid Tissue / Q000187:drug effects / Q000473:pathology; D008297:Male; D020556:Neutrophil Infiltration / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D013154:Spleen / Q000473:pathology; D013270:Stomach / Q000201:enzymology; D016559:Tacrolimus / Q000494:pharmacology*
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003907:Dexamethasone; D009195:Peroxidase; D016559:Tacrolimus