Three-dimensional MR pulmonary perfusion imaging and angiography with an injection of a new blood pool contrast agent B-22956/1.
Initial evaluation of a new blood pool agent, B-22956/1, for pulmonary imaging was performed in five domestic pigs with artificial embolism. Pre-embolism 3D pulmonary perfusion images were first acquired by injecting an extravascular agent, gadoteridol. The pulmonary arteries of the pigs were then occluded by the artificial emboli. Post-embolism perfusion scans were subsequently performed by injecting B-22956/1. Additional post-embolism high-spatial-resolution angiograms were also acquired. Parenchyma perfusion deficits were well depicted in the post-embolism perfusion maps. The post-embolism angiography clearly revealed the location and extent of the filling defects in the pulmonary vessels. Signal intensities of perfusion maps on the normal parenchyma were significantly improved (30%) by using B-22956/1, in comparison with perfusion images using gadoteridol (P < 0.01). Many pulmonary angiograms with approximately equal contrast could be obtained even at 22 minutes after the injection of B-22956/1. Our initial results indicate that blood pool agent B-22956/1 may provide opportunities for whole-lung-coverage perfusion mapping and additional high-resolution target angiograms after a single injection.
Zheng
J
J
Mallinkcrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kings Highway, St. Louis, MO 63110, USA. zhengj@mir.wustl.edu
Carr
J
J
Harris
K
K
Saker
M B
MB
Cavagna
F M
FM
Maggioni
F
F
Laub
G
G
Li
D
D
Finn
J P
JP
D000818:Animals; D003287:Contrast Media; D005682:Gadolinium; D006571:Heterocyclic Compounds; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds; D011652:Pulmonary Circulation / Q000502:physiology*; D011655:Pulmonary Embolism / Q000175:diagnosis; D013552:Swine
C440468:B-22956-1; D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium