[Renal expression of intercellular adhesion molecule-1 (ICAM-1) in IgA deposit mesangial nephropathy. A tubulointerstitial lesion marker].
BACKGROUND
The aim of this study was to determine the significance of the renal expression of ICAM-1 in IgA nephropathy (IgAN).


METHODS
First, we identified ICAM-1 (CD54) expression in tubular epithelial cells and interstitial leucocytes in renal biopsies from 45 patients with IgAN and 29 patients with non-glomerulonephritis nephropathy (non-GN). We then analysed the relationship between this expression and both histological and clinical data at the time of renal biopsy and after 2.4 (2) (X [SD]) years in IgAN, and 1.8 (1.5) years in non-GN.


RESULTS
In IgAN, tubular ICAM-1 positive staining was seen in 25 (55%) biopsies; it was associated with extracapillary proliferation, glomerulosclerosis involving less than 50% of glomerular area, interstitial cell infiltration and tubular atrophy. ICAM-1 positive interstitial leucocytes were 234 (307)/mm2; this expression correlated with glomerulosclerosis, tubular atrophy, interstitial fibrosis and serum creatinine (Cr) level. In patients with 50% increase in Cr level, ICAM-1 positive interstitial leucocytes were 516 (360)/mm2 as compared with 66 (87.8)/mm2 (U = 16; p < 0.005) in patients with stable Cr. In non-GN, tubular ICAM-1 expression was observed in 7 (24%) biopsies.


CONCLUSIONS
Tubular and Interstitial expression of ICAM-1 can be a marker of tubulointerstitial damage in IgAN. Interstitial ICAM-1, rather than tubular ICAM-1, may predict the progression of this disease.
Arrizabalaga
P
P
Servicio de Nefrología, Hospital Clínico, Barcelona. parrizabala@senefro.org
Solé
M
M
Abellana
R
R
de las Cuevas
X
X
Soler
J
J
Pascual
J
J
Ascaso
C
C
D000328:Adult; D015415:Biomarkers; D005260:Female; D005920:Glomerular Mesangium; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009395:Nephritis, Interstitial / Q000175:diagnosis* / Q000209:etiology
D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1