Human migraine models.
The need for experimental models is obvious. In animal models it is possible to study vascular responses, neurogenic inflammation, c-fos expression etc. However, the pathophysiology of migraine remains unsolved, why results from animal studies not directly can be related to the migraine attack, which is a human experience. A set-up for investigations of experimental headache and migraine in humans, has been evaluated and headache mechanisms explored by using nitroglycerin and other headache-inducing agents. Nitric oxide (NO) or other parts of the NO activated cascade seems to be responsible for the induced headache and migraine. Perspectives are discussed.
Iversen
H K
HK
Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark. hki@dadlnet.dk
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008881:Migraine Disorders / Q000139:chemically induced / Q000503:physiopathology; D008959:Models, Neurological; D005996:Nitroglycerin; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D005996:Nitroglycerin