title: Cytotoxic coumarins from Calophyllum dispar.
abstract: Six coumarins have been isolated from the fruits and the stem bark of Calophyllum dispar (Clusiaceae). The structures of these minor components were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these coumarins exhibited a significant cytotoxic activity against KB cells.
authors.affiliation: SONAS, UFR des Sciences Pharmaceutiques, 16 Bd Daviers, F-49100, Angers, France.
authors.forename: D
authors.initials: D
authors.lastname: Guilet
authors.forename: D
authors.initials: D
authors.lastname: Séraphin
authors.forename: D
authors.initials: D
authors.lastname: Rondeau
authors.forename: P
authors.initials: P
authors.lastname: Richomme
authors.forename: J
authors.initials: J
authors.lastname: Bruneton
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D028084:Clusiaceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins