[Studies on the synthesis of dl-ligustiphenol and its analogues].
S-( -- )-Ligustiphenol is a new sesquiterpene with anti-inflammatory and immunosuppressive activities.  In order to study its pharmacological activities, the total synthesis of its racemat was carried out by a six-step reaction sequence including bromination of aldehyde, iodination of m - cresol, protection of phenolic hydroxyl, Grignard reaction, Aldol condensation, etc.  The target compound was characterized by comparing its 1(H)-NMR, MS and IR spectra with natural ( -- )-ligustiphenol.  In order to study the structure-activity relationships of ligustiphenol, it five analogues were designed and synthesized.  The pharmacological screening of these analogues has been performed.
Huang
Y H
YH
Institute of Materia Medica, Chinese Academy of Medical Sciences and  Peking Union Medical College, Beijing 100050.
Yu
D Q
DQ
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology*; D030004:Ligusticum / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D012717:Sesquiterpenes; C442149:ligustiphenol