Highly active antiretroviral therapy induces specific changes in effector and central memory T cell sub-populations.
Highly active antiretroviral therapy (HAART) improves the immunodeficiency of HIV-infected individuals. In this report we show that HAART increases both naive (CD45RA+CD62L+) and central memory (CD45RO+CD62L+) CD4 lymphocytes. On CD8 lymphocytes, HAART induces an increase of naive cells associated with a consistent decrease of effector cells (CD45 RO+CD62L-). No specific differences in phenotypic changes were observed with different HAART regimens, suggesting that, once viral suppression is achieved, the pharmacological class of antiretroviral drugs does not affect immune reconstitution.
Muñoz-Calleja
C
C
Service of Clinical Immunology, Department of Internal Medicine, Ancona University Medical School, Italy.
Costantini
A
A
Silvestri
G
G
Butini
L
L
Regnery
C M
CM
Mancini
S
S
Montroni
M
M
D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D007156:Immunologic Memory / Q000187:drug effects*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology