Locus coeruleus noradrenergic lesions attenuate intraoral intake.
I.p. injections of DSP-4 in male rats decreased norepinephrine (NE) levels to varying degrees throughout the brain with 66.7% reductions in the hypothalamic paraventricular nucleus. Intake of intraorally infused sucrose was reduced for 14 days but daily pellet intake recovered within 5 days post-injection. Intraventricular NE restored intraoral sucrose intake in DSP-4-lesioned rats without affecting controls. Intraventricular infusion of neuropeptide Y (NPY) reduced intraoral intake in controls but had no effect in DSP-4-lesioned rats. NPY markedly inhibited intraoral intake in DSP-4-treated rats that also received NE. These data confirm studies showing that NPY decreases consummatory ingestive behavior and suggest that this inhibition involves ascending noradrenergic projections from locus coeruleus.
Ammar
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AA
Section of Applied Neuroendocrinology, Karolinska Institutet, Novum, S-141 57 Huddinge, Sweden.
Södersten
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Johnson
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D018663:Adrenergic Agents / Q000494:pharmacology; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology*; D001596:Benzylamines / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003714:Denervation; D019422:Dietary Sucrose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions / Q000502:physiology; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D008125:Locus Coeruleus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009410:Nerve Degeneration / Q000139:chemically induced / Q000503:physiopathology; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism*; D009478:Neuropeptide Y / Q000378:metabolism* / Q000494:pharmacology; D009498:Neurotoxins / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D018663:Adrenergic Agents; D001596:Benzylamines; D019422:Dietary Sucrose; D009478:Neuropeptide Y; D009498:Neurotoxins; D011506:Proteins; C012102:DSP 4; D009638:Norepinephrine