title: Asymmetric synthesis of a fully protected ent-actinoidinic acid.
abstract: [structure: see text] The asymmetric synthesis of a fully protected ent-actinoidinic acid derivative 14 is described. As key steps, an enantioselective deprotonation of an arene tricarbonylchromium(0) complex and a diastereoselective Suzuki coupling were applied. The asymmetric centers of the amino acid function were created via stereocontrolled Strecker reactions.
authors.affiliation: Department of Chemistry, Imperial College of Science Technology and Medicine, London SW7 2AZ, UK.
authors.forename: R
authors.initials: R
authors.lastname: Wilhelm
authors.forename: D A
authors.initials: DA
authors.lastname: Widdowson
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014640:Vancomycin / Q000031:analogs & derivatives / Q000138:chemical synthesis*
chemical_list: D000900:Anti-Bacterial Agents; C012164:actinoidins; D014640:Vancomycin