[Characterization of immunological parameters of the lacrimal fluid in patients with various types of the course of keratoconus].
Local immunity is analyzed in 81 patients (146 eyes) aged 16-49 years with three clinical patterns of keratocone. During long remission, IgG level was the maximum. In progressive disease, sIgA and transferrin levels were increased. The most pronounced shifts were detected in the patients with acute keratocone: increased concentrations of IgM, C3 and C4 complement components, alpha 1-antitrypsin, orosomucoid, lysozyme activity, and immune complexes. These data prompt the development of pathogenetically based approaches to the treatment of patients with various clinical immunological types of keratocone.
Gorskova
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EN
Sevost'ianov
E N
EN
Teplova
S N
SN
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003627:Data Interpretation, Statistical; D006801:Humans; D005779:Immunodiffusion; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007640:Keratoconus / Q000145:classification / Q000276:immunology*; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D013666:Tears / Q000276:immunology*
D000936:Antigen-Antibody Complex; D003176:Complement C3; D003181:Complement C4; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M