Transgenic mouse models of Alzheimer's disease.
Recent advances in the understanding of the genetic basis of Alzheimer's disease have enabled the production of transgenic mouse models of the disease. Utilizing both cDNA- and genomic-based approaches, these mouse models for Alzheimer's disease have already provided valuable insights into the pathogenesis of the disease and potential therapeutic interventions.
Hock
B J
BJ
Dept of Genetics, Case Western Reserve University, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106-4955, USA.
Lamb
B T
BT
D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics* / Q000628:therapy; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D018076:DNA, Complementary / Q000235:genetics; D004195:Disease Models, Animal; D023281:Genomics; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation
D016564:Amyloid beta-Protein Precursor; D018076:DNA, Complementary