title: Tumor necrosis factor-alpha gene polymorphisms in children with multiple sclerosis.
abstract: Tumor necrosis factor-alpha (TNF-alpha) is a cytokine implicated in the pathogenesis of infectious and autoimmune disorders including multiple sclerosis (MS). Childhood-onset MS presents some clinical and laboratory features differing from adult disease. We studied TNF-alpha - 238 G-->A and - 308 G-->A polymorphisms in 24 patients with childhood-onset MS using PCR-RFLP and compared them with healthy control subjects from the same population (n = 93). The genotypes and allele frequencies were not different between patient and control groups (p = 0.348, 95 %CI, 0.28 - 1.92, chi(2) = 0.10 and p = 0.797, 95 %CI, 0.312 - 2.285, chi(2) = 0.20 for - 238 and - 308 alleles, respectively). Although the size of the study group is small, these results do not support a role for TNF-alpha gene polymorphisms in susceptibility to MS in children.
authors.affiliation: Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey. banlar@gen.hun.edu.tr
authors.forename: B
authors.initials: B
authors.lastname: Anlar
authors.forename: M
authors.initials: M
authors.lastname: Alikaşifoglu
authors.forename: G
authors.initials: G
authors.lastname: Köse
authors.forename: A
authors.initials: A
authors.lastname: Güven
authors.forename: Y
authors.initials: Y
authors.lastname: Gürer
authors.forename: A
authors.initials: A
authors.lastname: Yakut
mesh_terms: D000293:Adolescent; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014421:Turkey
chemical_list: D014409:Tumor Necrosis Factor-alpha