title: Use of cisatracurium during fast-track cardiac surgery.
abstract: We prospectively studied spontaneous recovery from cisatracurium-induced neuromuscular block in 18 patients scheduled for cardiac surgery, and its suitability for fast-track cardiac surgery. Neuromuscular block was induced by an i.v. bolus (range 0.15-0.3 mg kg(-1)) and maintained by a continuous infusion (range 1.1-3.2 microg kg(-1) min(-1)) of cisatracurium until sternal closure. In the intensive care unit (ICU), spontaneous recovery was evaluated by the train-of-four (TOF) ratio measured at the adductor pollicis muscle. The ICU medical staff were unaware of the TOF ratios until sedation was stopped. At that time, if the TOF ratio was less than 0.9, sedation was recommenced. On arrival in ICU, all patients had residual paralysis. The mean time to reaching a TOF ratio of at least 0.9 was 102 min (range 74-144 min) after discontinuation of the cisatracurium infusion. Fifteen patients (83%) were successfully extubated during the first 8 h after stopping the cisatracurium infusion. Only one patient showed residual paralysis when sedation was discontinued. These results support the use of cisatracurium as a suitable neuromuscular blocking agent for fast-track cardiac surgery.
authors.affiliation: Département d'Anesthésie-Réanimation, Centre Hospitalier Universitaire La Milétrie, Poitiers, France.
authors.forename: A
authors.initials: A
authors.lastname: Ouattara
authors.forename: L
authors.initials: L
authors.lastname: Richard
authors.forename: J M
authors.initials: JM
authors.lastname: Charrière
authors.forename: H
authors.initials: H
authors.lastname: Lanquetot
authors.forename: P
authors.initials: P
authors.lastname: Corbi
authors.forename: B
authors.initials: B
authors.lastname: Debaene
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000762:Anesthesia Recovery Period; D001279:Atracurium / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002315:Cardiopulmonary Bypass; D003422:Critical Care; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019148:Neuromuscular Blockade; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011184:Postoperative Period; D011446:Prospective Studies
chemical_list: D009466:Neuromuscular Blocking Agents; D001279:Atracurium; C101584:cisatracurium