title: Prospective randomized trial comparing Nissen to Nissen-Rossetti technique for laparoscopic fundoplication.
abstract: BACKGROUND
  It has been suggested that division of the short gastric vessels (SGV) provides a more floppy Nissen fundoplication, for the treatment of reflux disease. The aim of the study was to assess whether Nissen fundoplication with division of SGV is associated with improved clinical outcome and laboratory findings.
  
  
  METHODS
  Fifty-six consecutive patients with gastroesophageal reflux disease (GERD) were randomly assigned to have a laparoscopic Nissen fundoplication either with division (24 patients; 15 men; mean age 51 +/- 15 years) or without division (32 patients; 23 men, mean age 47 +/- 14 years) of the SGV. Preoperative and postoperative investigation included clinical assessment, esophagoscopy, esophagogram, esophageal manometry, and 24-hour ambulatory esophageal pH monitoring.
  
  
  RESULTS
  Division of the SGV resulted in a significant increase of the operating time (P <0.0001). The operation abolished reflux in both groups. Also, both types of Nissen fundoplication significantly increased the amplitude of peristalsis at distal esophagus (division group: from 56 +/- 20 mm Hg to 64 +/- 25 mm Hg, P = 0.01; nondivision group: from 65 +/- 27 mm Hg to 75 +/- 26 mm Hg, P <0.001) and the lower esophageal sphincter pressure (division group: from 16 +/- 10 mm Hg to 24 +/- 7 mm Hg, P <0.001; nondivision group: from 22 +/- 8 mm Hg to 28 +/- 5 mm Hg, P <0.001). No differences in the incidence of postoperative severe dysphagia (division group: 5 of 24; nondivision group: 3 of 32) and overall esophageal transit were accounted between groups. However, division of the SGV was associated with a significant increased incidence of gas-bloating syndrome (division group, 13 of 24, versus nondivision group, 9 of 32, P = 0.02).
  
  
  CONCLUSIONS
  Division of the SGV at laparoscopic Nissen fundoplication for GERD does not improve clinical outcome and laboratory findings, while it is associated with prolongation of the operating time and increased incidence of gas-bloating syndrome.
authors.affiliation: Department of General Surgery, University Hospital of Heraklion, University of Crete Medical School, GR-711 10, Heraklion, Crete, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Chrysos
authors.forename: A
authors.initials: A
authors.lastname: Tzortzinis
authors.forename: J
authors.initials: J
authors.lastname: Tsiaoussis
authors.forename: H
authors.initials: H
authors.lastname: Athanasakis
authors.forename: J
authors.initials: J
authors.lastname: Vasssilakis
authors.forename: E
authors.initials: E
authors.lastname: Xynos
mesh_terms: D003680:Deglutition Disorders / Q000209:etiology; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000601:surgery; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010528:Peristalsis / Q000502:physiology; D011182:Postoperative Care; D011183:Postoperative Complications; D011446:Prospective Studies; D016896:Treatment Outcome