title: Prolonged survival of axons terminating within lesions of cat visual cortex.
abstract: It is well known that brain lesions made by the injection of ibotenic acid destroy neuronal cell bodies but do not kill passing axons. We have found that axons terminating within such lesions in visual cortex also survive for at least 2 months, despite the absence of available synaptic sites. We made tracer injections in area 17, and observed dense patches of anterograde label within lesions in other visual cortical areas. Furthermore, because the retinotopic site of the tracer injection was known, we could conclude that the retinotopic site was encompassed within the lesion.
authors.affiliation: Department of Biological Structure, University of Washington, P.O. Box 357420, Seattle, WA 98199, USA. garp@u.washington.edu
authors.forename: G A
authors.initials: GA
authors.lastname: Fowler
authors.forename: H
authors.initials: H
authors.lastname: Sherk
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D001931:Brain Mapping; D002415:Cats; D002470:Cell Survival / Q000187:drug effects* / Q000502:physiology; D003714:Denervation; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D007051:Ibotenic Acid / Q000494:pharmacology; D012183:Retrograde Degeneration / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D014793:Visual Cortex / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology*; D014795:Visual Pathways / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology
chemical_list: D018690:Excitatory Amino Acid Agonists; D007051:Ibotenic Acid