[Biological evaluation of the effect of beta-lactam antibiotics on apoptosis in human lymphoid cells in vitro].
Models are developed that allow the effect of beta-lactam antibiotics on the level of apoptosis in human lymphoid cells to be evaluated in vitro. The antibiotics produced a dose-dependent decrease in apoptosis of mature lymphocytes both under normal conditions and in the state of dexamethasone-induced immunodepression. The beta-lactam antibiotics also affect the apoptosis in a pre-B-lymphoblast model. The dexamethasone-induced apoptosis is inhibited by beta-lactam antibiotics only in high doses.
Reshetnikov
S I
SI
Pharmacology Department, Pharmaceutical Faculty, Sechenov Medical Academy, Nikitskii bul. 13, Moscow, 119021 Russia.
Shchiglenko
N A
NA
Aliautdin
R N
RN
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017209:Apoptosis; D015780:Carbapenems / Q000494:pharmacology; D002478:Cells, Cultured; D002511:Cephalosporins / Q000494:pharmacology; D006801:Humans; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008221:Lymphoid Tissue / Q000166:cytology* / Q000187:drug effects*; D010406:Penicillins / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002511:Cephalosporins; D010406:Penicillins