title: Functional genomics and metal metabolism.
abstract: Metal ions are essential nutrients, yet they can also be toxic if they over-accumulate. Homeostatic mechanisms and detoxification systems therefore precisely control their intracellular levels and distribution. The tools of functional genomics are rapidly accelerating understanding in this field, particularly in the yeast Saccharomyces cerevisiae.
authors.affiliation: Department of Nutritional Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA. eided@missouri.edu
authors.forename: D J
authors.initials: DJ
authors.lastname: Eide
mesh_terms: D003300:Copper / Q000378:metabolism; D005656:Fungal Proteins / Q000502:physiology; D020869:Gene Expression Profiling; D016680:Genome, Bacterial; D005978:Glutathione / Q000096:biosynthesis; D007501:Iron / Q000378:metabolism; D019216:Metals, Heavy / Q000378:metabolism*; D008956:Models, Chemical; D012329:RNA, Bacterial / Q000096:biosynthesis; D018085:Regulon; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors; D015032:Zinc / Q000378:metabolism
chemical_list: D005656:Fungal Proteins; D019216:Metals, Heavy; D012329:RNA, Bacterial; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C103264:ZAP1 protein, S cerevisiae; D003300:Copper; D007501:Iron; D005978:Glutathione; D015032:Zinc