title: Therapeutic intensive seizure analysis (TISA) in presurgical evaluation of Losigamone.
abstract: OBJECTIVE
  The new method TISA was used to evaluate Losigamone efficacy.
  
  
  METHODS
  Sixteen patients with pharmacoresistant partial seizures undergoing presurgical evaluation were randomized in this double-blind, placebo-controlled, parallel-group Losigamone monotherapy study under continuous video-EEG monitoring. Duration (in s, of each seizure and each ictal sign), intensity (grade zero to three), N/24h (number of seizures and ictal signs per 24 h), D/24h (seconds per 24 h covered by seizures and ictal signs) and seizure free intervals were recorded.
  
  
  RESULTS
  A total of 246 seizures were intensively analyzed. The duration and intensity of all seizures improved more in the active treatment group than in the placebo group. There was a statistically significant superiority in the duration of the seizure free interval in the Losigamone group. Ictal signs such as oro-alimentary automatisms and fumbling were improved during Losigamone treatment.
  
  
  CONCLUSIONS
  Losigamone has a preferred inhibitory effect on propagated epileptic activity. TISA is a sensitive method for evaluation of the selective effects of AEDs.
authors.affiliation: Department of Neurology, Epilepsy Center, University of Erlangen-Nuernberg, 91054 Erlangen, Germany. hermann.stefan@neuro.med.uni-erlangen.de
authors.forename: H
authors.initials: H
authors.lastname: Stefan
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: F
authors.initials: F
authors.lastname: Kerling
authors.forename: P
authors.initials: P
authors.lastname: Hopp
authors.forename: D
authors.initials: D
authors.lastname: Zhou
authors.forename: A
authors.initials: A
authors.lastname: Dienel
authors.forename: M
authors.initials: M
authors.lastname: Feichtinger
authors.forename: A
authors.initials: A
authors.lastname: Kirchner
authors.forename: E
authors.initials: E
authors.lastname: Pauli
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography; D005260:Female; D005663:Furans / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000188:drug therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D005663:Furans; C065427:losigame