Breast cancer presenting with the syndrome of inappropriate secretion of antidiuretic hormone after simple mastectomy.
A 71-year-old woman showed disorientation 7 days after simple mastectomy for right breast cancer. Computed tomography of the brain was normal. The level of serum sodium was very low (110 mEq/l), while the urine sodium level was normal. The osmolality of urine was higher (342 mosmol/kg) than that of serum (220 mosmol/kg). These data suggested a syndrome of inappropriate secretion of antidiuretic hormone. A fluid restriction, infusion of hypertonic saline and administration of diuretics gradually increased the level of serum sodium. Subsequently, disorientation disappeared. This is a rare case of the syndrome of inappropriate secretion of antidiuretic hormone caused by simple mastectomy, a relatively minor surgical procedure.
Hashida
H
H
Department of Internal Medicine, Ehime Prefectural Iyomishima Hospital.
Honda
T
T
Morimoto
H
H
Sasaki
T
T
Aibara
Y
Y
Yamanaka
M
M
D000368:Aged; D001943:Breast Neoplasms / Q000601:surgery*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D015413:Mastectomy, Simple / Q000009:adverse effects*; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood
D012964:Sodium