title: Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review.
abstract: 1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements in specificity and increased capacity. 3. Emerging technologies such as monolithic column chromatography and miniaturized chip-based systems are discussed.
authors.affiliation: Department of Bioanalysis and Drug Metabolism, GlaxoWellcome R&D, Ware, UK.
authors.forename: R S
authors.initials: RS
authors.lastname: Plumb
authors.forename: G J
authors.initials: GJ
authors.lastname: Dear
authors.forename: D N
authors.initials: DN
authors.lastname: Mallett
authors.forename: D M
authors.initials: DM
authors.lastname: Higton
authors.forename: S
authors.initials: S
authors.lastname: Pleasance
authors.forename: R A
authors.initials: RA
authors.lastname: Biddlecombe
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012371:Robotics
chemical_list: D004364:Pharmaceutical Preparations