An easy entry into berbane and alloyohimbane alkaloids via a 6-exo radical cyclization.
[reaction: see text] The pharmacologically important tetracyclic berbane and pentacyclic alloyohimbane structures were prepared efficiently in four steps including a stereoselective 6-exo radical cyclization using xanthates as the radical source.
Kaoudi
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Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France.
Miranda
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Zard
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D001600:Berberine Alkaloids / Q000138:chemical synthesis*; D046948:Secologanin Tryptamine Alkaloids / Q000138:chemical synthesis*; D013237:Stereoisomerism
D001600:Berberine Alkaloids; D046948:Secologanin Tryptamine Alkaloids