title: [Post-varicella thrombosis and factor V Leiden mutation].
abstract: BACKGROUND
  Varicella is a benign infectious disease that is rarely complicated by thrombosis. Factor V Leiden (FVL) mutation is presently recognized as the most common inherited cause of thrombosis. From a case report the link between varicella associated thrombosis and FVL is discussed.
  
  
  METHODS
  An eight year-old boy was admitted on 15th day of a varicella infection for difficulty to walk and painful legs. Doppler ultra sound of the lower limbs venous system showed thrombosis of the left iliac vein and femoral veins. Thrombophilia work-up revealed a FVL heterozygotic status for the patient. Biological screening for molecular abnormalities associated with thrombophilia led to the detection of a heterozygous inherited FVL mutation in the patient. Response to heparine followed by oral anticoagulant treatment was good.
  
  
  CONCLUSIONS
  Thrombosis associated with varicella in child is a rare event. We recommend to realize a thrombophilia screening in such patients. We also support varicella vaccination of children identified as having constitutional prothrombotic disorders like FVL mutation.
authors.affiliation: Service de pédiatrie, hématologie-oncologie pédiatrique, hôpital Saint-Georges, BP 166378, Beyrouth 6417, Liban. mirnamou@inco.com.lb
authors.forename: M
authors.initials: M
authors.lastname: Moussalem
authors.forename: R
authors.initials: R
authors.lastname: Sacy
authors.forename: N
authors.initials: N
authors.lastname: Hakime
authors.forename: N
authors.initials: N
authors.lastname: Sfer
authors.forename: J F
authors.initials: JF
authors.lastname: Schvedjf
mesh_terms: D002644:Chickenpox / Q000150:complications*; D002648:Child; D005165:Factor V / Q000235:genetics*; D006801:Humans; D008297:Male; D017354:Point Mutation; D013927:Thrombosis / Q000209:etiology*
chemical_list: C095381:factor V Leiden; D005165:Factor V