[Participation of the dopaminergic brain system in effects of glucocorticoid hormones].
Following the conditioning with dexamethasone, a dose-dependent place preference in non-preferred compartment was observed on the second test day in male Wistar rats. Amphetamine in subthreshold dose exerted no effect if administered alone and induced a place preference in an unbiased paradigm after pre-treatment with dexamethasone. Administration of D2-dopamine receptors' antagonist sulpiride 30 min prior to dexamethasone conditioning completely blocked the acquisition of the place preference. The D1-dopamine receptors' antagonist SCH23390 exerted no effect on the place conditioning. The findings suggest that the D2-dopamine receptors take part in conditioned place preference with dexamethasone.
Lebedev
A A
AA
Institute of Experimental Medicine, Russian Acad. Med. Sci, 197376, St. Petersburg, Acad. I. P. Pavlov St., 12, Russia.
Gurkovskaia
O V
OV
Nozdrachev
A D
AD
Shabanov
P D
PD
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology; D001921:Brain / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D012054:Reinforcement, Psychology; D013469:Sulpiride / Q000494:pharmacology
D001552:Benzazepines; D018492:Dopamine Antagonists; D005938:Glucocorticoids; D017448:Receptors, Dopamine D2; D013469:Sulpiride; D003907:Dexamethasone; D004298:Dopamine