title: Highly chemo-, diastereo-, and enantioselective reduction of 1,2-dialkyl-3-aryl-1,3-diketones for preparation of aldol-type compounds.
abstract: [reaction: see text]. Highly chemo-, diastereo-, and enantioselective borohydride reduction of 2-substituted-1,3-diketones was achieved in the presence of the optically active beta-ketoiminato cobalt complex catalysts to afford the optically active 2-substituted-3-hydroxyketones. The present catalytic and enantioselective reduction could provide an alternative potential for preparation of optically active anti-aldol-type compounds.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: K
authors.initials: K
authors.lastname: Koyasu
authors.forename: D
authors.initials: D
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Ikeno
authors.forename: T
authors.initials: T
authors.lastname: Yamada