Pharmacological analysis of wine-stimulated gastric acid secretion in dogs.
Wine apparently stimulates gastric acid secretion both in man and animals, yet the underlying mechanism remains unclear. The present study was attempted to clarify the pharmacological properties involved in gastric acid secretion stimulated by wine in beagle dogs. Commercially available red or white wine, 14% ethanol, or 10% peptone meal was intragastrically administered to dogs with vagally denervated Heidenhain pouches. Gastric acid secretion was stimulated by both red and white wines (25-50 ml) for 45-60 min. While S-0509 only tended to inhibit wine-stimulated gastric acid secretion, both atropine and famotidine significantly inhibited wine-stimulated gastric acid secretion. Plasma gastrin level was not significantly increased by administration of red and white wines. Administration of 14% ethanol also stimulated gastric acid secretion, but the effect was about half of that of wine. Combined administration of wine and peptone resulted in a biphasic stimulation of gastric acid secretion. S-0509, atropine and famotidine significantly inhibited wine+peptone meal stimulation, yet the order of inhibition of cumulative acid secretion was in the order, famotidine>atropine>S-0509. It was concluded that wine stimulated gastric acid secretion in denervated dogs via acethylcholine- and histamine-dependent mechanisms, but nearly independent from the intervention of gastrin.
Tsukimi
Y
Y
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan. tsukimi@poppy.kyoto-phu.ac.jp
Ogawa
T
T
Okabe
S
S
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001577:Benzophenones / Q000494:pharmacology*; D004285:Dogs; D000431:Ethanol / Q000494:pharmacology; D015738:Famotidine / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D009994:Osmolar Concentration; D010461:Peptones / Q000494:pharmacology; D010671:Phenylurea Compounds / Q000494:pharmacology*; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors; D014920:Wine
D001577:Benzophenones; D005755:Gastrins; D006635:Histamine H2 Antagonists; D018727:Muscarinic Antagonists; D010461:Peptones; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C109118:S 0509; D000431:Ethanol; D015738:Famotidine; D001285:Atropine