Inhibitory effect of flavonoid derivatives on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors.
To search for possible anti-tumor promoters, ten flavonoid derivatives (1-10) synthesized from morin and quercetin were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these compounds, pentaallyl ethers (9, 10) showed significant inhibitory effects on EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate. Further, quercetin pentaallyl ether (10) exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
Iwase
Y
Y
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyubancho, Hyogo 663-8179, Nishinomiya, Japan.
Takemura
Y
Y
Ju-ichi
M
M
Mukainaka
T
T
Ichiishi
E
E
Ito
C
C
Furukawa
H
H
Yano
M
M
Tokuda
H
H
Nishino
H
H
D000818:Animals; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*; D004854:Herpesvirus 4, Human / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D008956:Models, Chemical; D010212:Papilloma / Q000209:etiology / Q000378:metabolism; D011794:Quercetin / Q000737:chemistry / Q000378:metabolism; D012878:Skin Neoplasms / Q000209:etiology* / Q000517:prevention & control* / Q000821:virology*; D013755:Tetradecanoylphorbol Acetate; D013997:Time Factors; D047309:Flavones
D002273:Carcinogens; D005419:Flavonoids; D011794:Quercetin; D013755:Tetradecanoylphorbol Acetate; C008548:morin; D047309:Flavones