title: The CHASE domain: a predicted ligand-binding module in plant cytokinin receptors and other eukaryotic and bacterial receptors.
abstract: A novel, 200-230 amino acid extracellular domain was identified in the plant cytokinin receptor Cre1, in the receptor-histidine kinase DhkA and the adenylyl cyclase Acg from the slime mold Dictyostelium discoideum, and in a variety of other receptor-like proteins from bacteria and eukaryotes. The domain is predicted to bind diverse low molecular weight ligands, such as the cytokinin-like adenine derivatives or peptides, and mediate signal transduction through the respective receptors.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
authors.forename: V
authors.initials: V
authors.lastname: Anantharaman
authors.forename: L
authors.initials: L
authors.lastname: Aravind
mesh_terms: D000262:Adenylyl Cyclases / Q000737:chemistry / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D029681:Arabidopsis Proteins; D001665:Binding Sites; D003583:Cytokinins / Q000378:metabolism; D004023:Dictyostelium / Q000201:enzymology / Q000235:genetics; D008024:Ligands; D008969:Molecular Sequence Data; D010944:Plants / Q000235:genetics / Q000378:metabolism; D011494:Protein Kinases / Q000737:chemistry* / Q000235:genetics; D017434:Protein Structure, Tertiary; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D029681:Arabidopsis Proteins; D003583:Cytokinins; D008024:Ligands; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface; D011494:Protein Kinases; C101160:DhkA protein, Dictyostelium discoideum; C421783:WOL protein, Arabidopsis; C101765:ACG protein, Dictyostelium discoideum; D000262:Adenylyl Cyclases