Toxicokinetics of ergovaline in the horse after an intravenous administration.
The toxicokinetics of ergovaline (an ergopeptine mycotoxin present in some grasses infected with endophytic fungus of the genus Neotyphodium) were studied after intravenous administration of a single dose of 15 microg/kg bwt in four gelding horses. Plasma ergovaline concentrations were measured by high performance liquid chromatography, and the kinetic data were described by a three-compartment model. The elimination half-life and the total clearance of ergovaline were found to be 56.83 +/- 13.48 min and 0.020 +/- 0.004 L/min x kg, respectively. According to the toxicological data previously reported in the horse, and in spite of the very low dose administered, clinical signs were observed, including excessive coolness of the ears and the nose, excessive sweating and prostration.
Bony
S
S
UMR 188 INRA-ENVL Comparative Metabolism and Toxicology of Xenobiotics, School of Veterinary Medicine of Lyon, Marcy l'Etoile, France. s.bony@vet-lyon.fr
Durix
A
A
Leblond
A
A
Jaussaud
P
P
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004879:Ergotamines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D006736:Horses / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D008657:Metabolic Clearance Rate; D009183:Mycotoxins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics
D004879:Ergotamines; D009183:Mycotoxins; D014662:Vasoconstrictor Agents; C076760:ergovaline