ATP-sensitive potassium channels in dopaminergic neurons: transducers of mitochondrial dysfunction.
ATP-sensitive potassium (K(ATP)) channels directly couple the metabolic state of a cell to its electrical activity. Dopaminergic midbrain neurons express alternative types of K(ATP) channels mediating their differential response to mitochondrial complex I inhibition. Because reduced complex I activity is present in Parkinson's Disease, differential K(ATP) channel expression suggests a novel candidate mechanism for selective dopaminergic degeneration.
Liss
B
B
MRC Anatomical Neuropharmacology Unit, University of Oxford, OX1 3TH Oxford, UK.
Roeper
J
J
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004298:Dopamine / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism; D028361:Mitochondrial Diseases / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism; D015221:Potassium Channels / Q000737:chemistry / Q000378:metabolism*
D015221:Potassium Channels; D000255:Adenosine Triphosphate; D004298:Dopamine