[Absorption kinetics of C14-GABA and its vitamin B conjugates in isolated bovine retina].
Absorption by the bovine retina of physiological concentration of PLP-GABA increase clearing 2-32 minutes of incubation in difference of GABA and its non metabolic preparations, which store up as much as possible in first minutes: picamilon > PLP-GABA > GABA > panthogam > biotinil-GABA. Kinetics of transport of GABA and its preparations into retina has a complex character. By the growth of concentration from 33 mM to 528 mM, it is linear for picamilion, showing diffusion, and not linear for GABA, PLP-GABA and panthogam, showing differently systems of its transport. And only GABA transport is activated by Na-ions.
Rozanova
Z A
ZA
Institute of Eye Diseases and Tissue Therapy named by Filatov, AMS of Ukraine, Odessa.
D000042:Absorption; D000818:Animals; D002250:Carbon Radioisotopes / Q000378:metabolism*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008297:Male; D012160:Retina / Q000378:metabolism*; D013997:Time Factors; D014803:Vitamin B Complex / Q000737:chemistry* / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D014803:Vitamin B Complex; D005680:gamma-Aminobutyric Acid