A new stroke marker as detected by serum phosphoglycerate mutase B-type isozyme.
The diagnostic significance of phosphoglycerate mutase (PGM) B-type isozyme activity capable of being inducible under hypoxia at the gene level as a serum marker for cerebral stroke was investigated. The normal level (mean +/- 2 SD) in human serum was determined to be 38 +/- 18 units/L. Within 2 h after the onset of cerebral stroke (n = 65), B-type isozyme activity was elevated to 68 +/- 36 units/L, and retained to be higher level until 1-3 days. Serum B-type isozyme activities of 52 survival cases and 13 dead cases, being judged at the period of 1-2 months after the onset, were retrospectively compared; B-type isozyme activity that had been measured within 24 h after the onset was significantly higher (81 +/- 42 units/L) for the dead cases than for survival cases (57 +/- 27 units/L) with P < 0.05. These results suggest that serum PGM B-type isozyme has the potential as a novel marker for diagnosis of cerebral stroke and its severity.
Hayashi
T
T
Osaka Medical College, Osaka, Japan.
Matuo
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004796:Clinical Enzyme Tests; D006259:Craniocerebral Trauma / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology; D010736:Phosphoglycerate Mutase / Q000097:blood*; D012016:Reference Values; D020521:Stroke / Q000175:diagnosis* / Q000201:enzymology
D015415:Biomarkers; D007527:Isoenzymes; D010736:Phosphoglycerate Mutase