title: Chemohyperthermia for advanced abdominal malignancies: a new procedure with closed abdomen and previously performed anastomosis.
abstract: ChemoHyperthermic Peritoneal Perfusion (CHPP) after cytoreductive surgery is a relatively new procedure in the treatment of abdominal carcinomatosis or sarcomatosis. An assessment of the CHPP technique performed on 20 patients suffering from abdominal malignancies was carried out. After surgical debulking and gastrointestinal anastomosis, two Tenckhoff catheters were positioned for the immediate performance of CHPP, which was carried out at 42-43 degrees C for 1 h, after closing the abdomen. In 19 assessable patients, 47.3% and 36.8% complete responses (CR) were recorded at 1 and 6 months, respectively, with responses of 37.5% in patients affected with gastrointestinal cancer and 50% in patients affected with ovarian cancer. CR were obtained only in patients who had undergone accurate peritoneal debulking. Survival rate for gastrointestinal and ovarian cancer was 68% at 12 months. Patients who underwent radical cytoreductive surgery are all alive at a follow-up median time of 17 months. Two anastomotic leakages with spontaneous recovery were observed, along with one hydrothorax, which was immediately drained during the procedure, three cases of chemotherapic gastrointestinal toxicity, one sepsis, one renal failure that required a transient dialysis, and one cholecystitis that required cholecystectomy. One patient died 30 days after CHPP of a cardiac ischaemia not strictly related to the surgical procedure. In the authors' experience, CHPP with closed abdomen after reconstructive gastrointestinal surgery is a safe and feasible treatment with acceptable side effects.
authors.affiliation: Service of Surgical Oncology, University of Turin, Molinette Hospital, Torino, Italy. zanoncl@tin.it
authors.forename: C
authors.initials: C
authors.lastname: Zanon
authors.forename: R
authors.initials: R
authors.lastname: Clara
authors.forename: M
authors.initials: M
authors.lastname: Bortolini
authors.forename: A
authors.initials: A
authors.lastname: Malossi
authors.forename: R
authors.initials: R
authors.lastname: Moscato
authors.forename: P
authors.initials: P
authors.lastname: Celoria
authors.forename: M
authors.initials: M
authors.lastname: de Andrea
authors.forename: M
authors.initials: M
authors.lastname: Rizzo
authors.forename: I
authors.initials: I
authors.lastname: Chiappino
authors.forename: M
authors.initials: M
authors.lastname: Grazia Sciuto
authors.forename: A
authors.initials: A
authors.lastname: Mussa
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000628:therapy*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006979:Hyperthermia, Induced; D016685:Mitomycin / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D016685:Mitomycin; D002945:Cisplatin