Immunological aspects in migraine: increase of IL-10 plasma levels during attack.
In the present study, 23 patients with migraine without aura were monitored during a migraine attack. Plasma levels of interleukin (IL)-4, IL-5, IL-10, and interferon-gamma were measured by enzyme-linked immunosorbent assay techniques. Interestingly, we observed low to undetectable IL-5 and IL-4 levels, whereas high IL-10 levels were seen in 52.2% of the patients. Interferon-gamma plasma levels were undetectable in all patients. After treatment with sumatriptan, 10 patients showed a subsequent decrease in IL-10 and an increase in both IL-4 and IL-5 plasma levels. Although these findings are derived from a limited number of patients, the apparent return to the IL-4 and IL-5 cytokine profile observed during the interictal period leads us to speculate that a preferential enhancement of TH2-type cytokine production may contribute to the pathogenesis of migraine.
Munno
I
I
Department of Internal Medicine, Immunology, and Infectious Disease, University of Bari, Italy.
Marinaro
M
M
Bassi
A
A
Cassiano
M A
MA
Causarano
V
V
Centonze
V
V
D000328:Adult; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000188:drug therapy / Q000276:immunology*; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D018170:Sumatriptan / Q000627:therapeutic use; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
D015848:Interleukin-5; D017366:Serotonin Receptor Agonists; D014662:Vasoconstrictor Agents; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma; D018170:Sumatriptan