Histopathological studies on virulence of dipeptidyl aminopeptidase IV (DPPIV) of Porphyromonas gingivalis in a mouse abscess model: use of a DPPIV-deficient mutant.
To elucidate the role of dipeptidyl aminopeptidase IV (DPPIV) in the virulence of Porphyromonas gingivalis, mice were infected with either a wild-type strain or a DPPIV-deficient mutant using an abscess model. Histopathological analysis of the resulting lesions indicated that DPPIV participates in virulence through the destruction of connective tissue and the less effective mobilization of inflammatory cells.
Yagishita
H
H
Department of Pathology, Nippon Dental University, Fujimi 1-9-20, Chiyoda-ku, Tokyo 102-8159, Japan.
Kumagai
Y
Y
Konishi
K
K
Takahashi
Y
Y
Aoba
T
T
Yoshikawa
M
M
D000038:Abscess / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D000818:Animals; D016866:Bacteroidaceae Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D018819:Dipeptidyl Peptidase 4 / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D016966:Porphyromonas gingivalis / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence
D018819:Dipeptidyl Peptidase 4