[Observation of antiarrhythmic effects of Cinnamomum migao H. W. Li on experimental arrhythmia].
OBJECTIVE
To investigate the effects of Cinnamomum migao on experimental arrhythmia.


METHODS
Arrhythmic models of mice, rabbits, guinea pigs and rats were built using chloroform(Chl), adrenalin(Adr), strophanthin-K (Spt-K) and barium chloride (BaCl2). The affected animals were divided randomly into three groups: control group, Cinnamomum migao (CV-3) group and mexiletine (MXL) group, so as to observe and compare the antiarrhythmic effects.


RESULTS
CV-3 could reduce the incidence of ventricular fibrillation caused by ch1 in mice and the ventricular tachycardia induced by Adr in rabbits, delay the onset time of this arrhythmia, increase the arrhythmic doses of Spt-K in guinea pigs, reduce the incidence of some arrhythmia caused by BaCl2 in rats and slow down their heart rate.


CONCLUSIONS
CV-3 has obvious antiarrhythmic effects on experimental arrhythmia. The mechanism of these effects is probably related to the arrest of the intraflow of Na+, Ca2+ in the cardiac cells and the depression of their cardiac autoarrhythmicity and conductivity.
Sui
Y
Y
Department of Pharmacology, Guiyang College of TCM, Guiyang 550002.
Qiu
D
D
Xie
C
C
Chen
K
K
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D017609:Barium Compounds; D002712:Chlorides; D002725:Chloroform; D027424:Cinnamomum / Q000737:chemistry*; D004837:Epinephrine; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000302:isolation & purification / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017180:Tachycardia, Ventricular / Q000139:chemically induced / Q000517:prevention & control; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control
D017609:Barium Compounds; D002712:Chlorides; D009822:Oils, Volatile; C024986:barium chloride; D002725:Chloroform; D004837:Epinephrine