Switching enantiofacial selectivities using one chiral source: catalytic enantioselective synthesis of the key intermediate for (20S)-camptothecin family by (S)-selective cyanosilylation of ketones.
Yabu
K
K
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Masumoto
S
S
Yamasaki
S
S
Hamashima
Y
Y
Kanai
M
M
Du
W
W
Curran
D P
DP
Shibasaki
M
M
D002166:Camptothecin / Q000138:chemical synthesis*; D003486:Cyanides / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D013237:Stereoisomerism; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
D003486:Cyanides; D014297:Trimethylsilyl Compounds; C058010:trimethylsilyl cyanide; D005947:Glucose; D002166:Camptothecin