title: Coffee in the cornflakes: time-of-day as a modulator of executive response control.
abstract: Previous self-report based research has revealed a heightened propensity to slips-of-action in the early morning and at the end of the day. Here, we examined performance variability among healthy young adults as a function of time-of-day on a clinical task that is sensitive to absent-minded slips in brain-injured groups. We found significantly higher error rates at 1 pm and 7 pm compared with 1 am and 7 pm, and significant correlations between errors and two subjective sleepiness scales. No circadian modulation of the more routine aspects of the task was observed suggesting some specificity to the effect. Given evidence that the circadian cycle differentially affects different brain regions, and links between sleep deprivation and 'normal' dysexecutive behaviour, examining variation over the course of the day can prove a useful additional methodology in this area
authors.affiliation: MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, CB2 2EF, Cambridge, UK. tom.manly@mrc-cbu.cam.ac.uk
authors.forename: Tom
authors.initials: T
authors.lastname: Manly
authors.forename: Geraint H
authors.initials: GH
authors.lastname: Lewis
authors.forename: Ian H
authors.initials: IH
authors.lastname: Robertson
authors.forename: Peter C
authors.initials: PC
authors.lastname: Watson
authors.forename: Avijit  K
authors.initials: A
authors.lastname: Datta
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012890:Sleep / Q000502:physiology; D013647:Task Performance and Analysis; D013997:Time Factors