Roles of central interleukin-1 on stress-induced-hypertension and footshock-induced-analgesia in rats.
Central interleukin-1 (IL-1) plays an important role in mediating the neural, endocrine, and behavioral responses to stressors. Here we tested whether central IL-1 is involved in stress-induced hypertension or footshock (FS)-induced-analgesia. We observed that: (1) intracerebral ventricular injection of (ICV) IL-1beta induced pressor responses; (2) hypertension induced by IL-1beta was blocked by ICV an IL-1 antagonist, IL-1ra; (3) ICV IL-1ra attenuated the pressor response induced by FS but intravenous injection of IL-1ra did not significantly reduce this response; (4) the hypertensive response to conditioned fear stimuli was reversed by ICV IL-1ra; (5) FS-induced-analgesia was attenuated by ICV IL-1ra and this effect disappeared 15 min after ICV IL-1ra. These results suggest that both the pressor response to FS or conditioned fear stimuli and short lasting analgesia induced by FS are mediated by central IL-1.
Zou
C J
CJ
Department of Physiology and Pathophysiology, Health Science Center, Peking University, 100083, People's Republic of, Beijing, China. zouc@mail.bjmu.edu.cn
Liu
J D
JD
Zhou
Y C
YC
D000698:Analgesia / Q000379:methods; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D004347:Drug Interactions / Q000502:physiology; D004558:Electric Stimulation / Q000009:adverse effects; D005239:Fear / Q000187:drug effects / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D007276:Injections, Intraventricular; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008297:Male; D017288:Pain Threshold / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012795:Sialoglycoproteins / Q000494:pharmacology; D013312:Stress, Physiological / Q000378:metabolism* / Q000503:physiopathology
D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D012795:Sialoglycoproteins