title: Transdermal fentanyl therapy for pains in children with infantile neuronal ceroid lipofuscinosis.
abstract: We used infantile neuronal ceroid lipofuscinosis (INCL), in which deterioration of the central nervous system is extremely rapid, to study constant release of an opioid for pains of central origin in a metabolic disease. The effect of a transdermal fentanyl patch was studied in five children with INCL. In two of them, measurements of 17 fentanyl serum concentrations and also visual analogue pain scale were obtained during a 15-day study period. Low doses of transdermal fentanyl usually provided good pain relief for the first two days, but not for the third day, of the three-day patch change interval. Pain relief of this type seems mandatory for pains mostly of central origin.
authors.affiliation: Department of Child Neurology, Hospital for Children and Adolescents, University of Helsinki, Finland.
authors.forename: M K
authors.initials: MK
authors.lastname: Mannerkoski
authors.forename: H J
authors.initials: HJ
authors.lastname: Heiskala
authors.forename: P R
authors.initials: PR
authors.lastname: Santavuori
authors.forename: J A
authors.initials: JA
authors.lastname: Pouttu
mesh_terms: D000279:Administration, Cutaneous; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D002648:Child; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D009472:Neuronal Ceroid-Lipofuscinoses / Q000150:complications*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl