The effect of oral aspartame administration on the balance of magnesium in the rat.
The aim of the present work was to determine the effect of aspartame administration on the excretion of magnesium and its distribution in the various rat tissues and organs. The present results have shown that aspartame administration influences the balance of magnesium in the organism, since in some organs and tissues (heart, lungs, kidneys, adrenals, jejunum, hair and blood) it is accumulated, while other organs (liver and testes) are deprived of it. Aspartame administration also affects the excretion of magnesium from the organism, since it decreases the concentration of magnesium in both urine and feces.
Kovatsi
L
L
Laboratory of Forensic Medicine & Toxicology, Faculty of Medicine, Aristotle University of Thessaloniki, Greece. kovatsi@med.auth.gr
Tsouggas
M
M
D000284:Administration, Oral; D000818:Animals; D001218:Aspartame / Q000008:administration & dosage* / Q000494:pharmacology; D002614:Chelating Agents / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D008274:Magnesium / Q000378:metabolism* / Q000652:urine; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D002614:Chelating Agents; D008274:Magnesium; D001218:Aspartame