Association between Kaposi's sarcoma and atherosclerosis: implications for gammaherpesviruses and vascular disease.
The treatment of HIV-positive patients with protease inhibitors has been suggested to increase their risk of atherosclerosis. The cause of this accelerated atherogenesis is unknown, but on the basis of previous studies we postulated that it could be linked to the presence of human herpesvirus-8. A retrospective analysis of post-mortem reports showed a strong correlation between Kaposi's sarcoma and the presence of atheroma. This hypothesis merits further investigation.
Grahame-Clarke
C
C
Centre for Clinical Pharmacology, Department of Medicine, Royal Free and University Colleg Medical School, UK.
Alber
D G
DG
Lucas
S B
SB
Miller
R
R
Vallance
P
P
D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D000328:Adult; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D001344:Autopsy; D002318:Cardiovascular Diseases / Q000209:etiology; D002417:Cattle; D018142:Gammaherpesvirinae; D006566:Herpesviridae Infections / Q000150:complications; D019288:Herpesvirus 8, Human; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000150:complications*