Cladospolide D, a new 12-membered macrolide antibiotic produced by Cladosporium sp. FT-0012.
A new antibiotic termed cladospolide D was isolated along with the known cladospolides A and B from the fermentation broth of Cladosporium sp. FT-0012 by solvent extraction, ODS column chromatography and preparative HPLC. The structure of cladospolide D was deduced to be (E)-2-dodecen-5-hydroxy-11-olide-4-one. Cladospolide D showed antifungal activity against Pyricularia oryzae and Mucor racemosus.
Zhang
H
H
The Kitasato Institute, Tokyo, Japan.
Tomoda
H
H
Tabata
N
N
Miura
H
H
Namikoshi
M
M
Yamaguchi
Y
Y
Masuma
R
R
Omura
S
S
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002963:Cladosporium / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D005285:Fermentation; D018942:Macrolides; D008855:Microscopy, Electron, Scanning; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014974:Xanthomonas / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C437366:cladospolide D