title: Intracerebroventricular injection of exendin (5-39) increases food intake of layer-type chicks but not broiler chicks.
abstract: To clarify the involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks, we examined the central effect of GLP-1 antagonist, exendin (5-39) on food intake. Intracerebroventricular co-injection of exendin (5-39) with GLP-1 attenuated the anorexigenic effect of GLP-1 in layer-type chicks. Furthermore, exendin (5-39) enhanced food intake of layer-type chicks under ad libitum feeding. However, this effect was not observed in broiler chicks. Therefore, endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks.
authors.affiliation: United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, 183-8509, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tachibana
authors.forename: K
authors.initials: K
authors.lastname: Sugahara
authors.forename: A
authors.initials: A
authors.lastname: Ohgushi
authors.forename: R
authors.initials: R
authors.lastname: Ando
authors.forename: K
authors.initials: K
authors.lastname: Sashihara
authors.forename: T
authors.initials: T
authors.lastname: Yoshimatsu
authors.forename: M
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002645:Chickens; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005934:Glucagon / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D052216:Glucagon-Like Peptide 1; D007276:Injections, Intraventricular; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D011498:Protein Precursors / Q000008:administration & dosage / Q000037:antagonists & inhibitors
chemical_list: D010446:Peptide Fragments; D011498:Protein Precursors; C417195:exendin (5-39); D052216:Glucagon-Like Peptide 1; D005934:Glucagon