title: [Sedative premedication is necessary for infants in anesthetic induction under the presence of mother].
abstract: We examined the necessity of sedative premedication for elective operation of childhood when induction was performed beside the mother. One hundred and nine patients (aged from 2 to 8 years) were assigned randomly to two groups; midazolam (0.5 mg.kg-1, orally, n = 56) was administered 45 min before induction in Group M, and vehicle was administered (n = 53) in Group C. The differences between the two groups about their calmness and behavior were investigated using double blind method, and analyzed according to their ages, as infants (2 to 4 years), kindergarteners (5 to 6 years) and school children (7 to 8 years). The significantly higher incidences of agitation or alertness were observed in infants of Group C (P < 0.05) and all other patients were calm and well sedated. We conclude that sedative premedication is necessary in infants even if induction is performed beside patient's mothers.
authors.affiliation: Department of Anesthesia, Yamagata Prefectural Nihonkai Hospital, Sakata 998-8501.
authors.forename: K
authors.initials: K
authors.lastname: Shinozaki
authors.forename: S
authors.initials: S
authors.lastname: Amagasa
authors.forename: N
authors.initials: N
authors.lastname: Yokoo
authors.forename: A
authors.initials: A
authors.lastname: Yamazaki
authors.forename: I
authors.initials: I
authors.lastname: Nasu
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
mesh_terms: D000768:Anesthesia, General / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D009035:Mothers; D011229:Preanesthetic Medication; D011292:Premedication / Q000523:psychology
chemical_list: D006993:Hypnotics and Sedatives