Balance control and posture in anxious mice improved by SSRI treatment.
A task requiring dynamic postural stabilisation during locomotion in a conflicting visual vestibular environment (rotating beam), has been devised to assess anxiety-related balance impairments and postural changes in mice. The model, already validated with acutely administered diazepam, was used to assess the action of two chronically administered selective serotonin reuptake inhibitors (SSRIs), fluoxetine and paroxetine. On three behavioural measures (imbalance, elevation of trunk and angle of tail), observed in anxious BALB/cByJ mice, both compounds had the same diazepam-like effects: reduction in number of imbalances, higher elevation of trunk and increase in tail angle. These data suggest, for the first time, that SSRIs should be useful in the treatment of anxiety-induced balance impairments.
Venault
P
P
CNRS UMR7593 Vulnérabilité, Adaptation et Psychopathologie, CHU Pitié-Salpêtrière, 91, bd de l'Hôpital 75013 Paris, France.
Rudrauf
D
D
Lepicard
E M
EM
Berthoz
A
A
Jouvent
R
R
Chapouthier
G
G
D000818:Animals; D001007:Anxiety / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D002490:Central Nervous System / Q000187:drug effects / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics*; D017374:Paroxetine / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects* / Q000502:physiology; D011187:Posture / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012727:Sex Characteristics; D015837:Vestibular Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors