[Experimental studies on anti-inflammatory, antipyretic and diuretic effects of several species of tongcao and xiao-tongcao].
OBJECTIVE
To observe and compare the anti-inflammatory, antipyretic and diuretic effects of three kinds of Tongcao(Tongtuomu, Panyezhangyeshu and Luosan) and seven kinds of Xiao-tongcao(Ximashanjinjiehua, Xinanxiuqiu1. 2., Ditanghua, Suixuezhangcai, Qingjiaye and Zhongguo jinjiehua).


METHODS
Decoctions prepared from the above kinds of Tongcao and Xiao-tongcao crude drugs were given to rats at dosages of 8 g/kg and 4 g/kg by ig. Pharmacological actions were observed by means of carrageenan-induced swelling paws, fever models induced by beer-yeast or carrageenan and metabolic cage method in rats.


RESULTS
All the experimental decoctions could inhibit carrageenan-induced swelling of rat paws in different degrees and exerted anti-pyretic effect on rat fever models induced by beer-yeast or carrageenan. Three kinds of Xiaotongcao(Ximashanjingjiehua, Xinanxiuqui2., Zhongguojinjiehua) had obvious diuretic effect on rats.


CONCLUSIONS
Decoctions of different species of Tongcao and Xiao-tongcao all have anti-inflammatory, antipyretic and diuretic effects, thus providing some pharmacologic basis for the efficacy assay, clinical application, species collation and quality study of Tongcao and Xiao-tongcao.
Shen
Y
Y
Chengdu University of TCM, Chengdu 610075.
Zeng
N
N
Jia
M
M
Zhang
Y
Y
Wei
Y
Y
Ma
Y
Y
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan; D004232:Diuretics / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000145:classification / Q000627:therapeutic use*; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry* / Q000145:classification; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004232:Diuretics; D004365:Drugs, Chinese Herbal; D002351:Carrageenan