Dust-induced interstitial lung disease in the tropics.
Inhalation of dusts is an important cause of interstitial lung disease in the tropical countries such as India. While dusts of organic origin, such as the cotton dust causing byssinosis, generally cause bronchial or bronchiolar involvement and hypersensitivity pneumonitis, inorganic metallic dusts cause progressive pulmonary fibrosis. Silicosis, coal workers' pneumoconiosis, and asbestosis are the three most commonly recognized forms of pneumoconiotic pulmonary fibrosis. Pulmonary tuberculosis is an important complication seen in up to 50% of patients of silicosis in some reports from India. The presentation is generally chronic, although acute and accelerated forms of silicosis are known when the exposures are heavy. Breathlessness, dry cough, and general constitutional symptoms are commonly seen. Patients with silicotuberculosis or other forms of infection may also have significant expectoration, hemoptysis, fever, and rapid progression. Respiratory failure and chronic cor pulmonale occur in the later stages. The diagnosis is easily established if the occupational history is available. Dense nodular opacities on chest roentgenograms, which may be large in patients with massive pulmonary fibrosis, are characteristic. Emphysematous changes generally appear in advanced stages or in patients who smoke. Bronchoalveolar lavage and/or lung biopsy may occasionally be required to establish or exclude other causes of interstitial lung disease. Treatment is largely palliative, although a variety of drugs including corticosteroids and procedures such as whole lung lavage have been tried. None of these methods has yet been found successful in the treatment. Preventive safety steps, including removal of the patient from the site of exposure, are the only effective strategies to control disease progression.
Jindal
S K
SK
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. skjindal@cha.i91.net
Aggarwal
A N
AN
Gupta
D
D
D001195:Asbestosis / Q000175:diagnosis; D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D002095:Byssinosis / Q000175:diagnosis; D003031:Coal / Q000633:toxicity; D003032:Coal Mining; D004391:Dust / Q000009:adverse effects*; D006801:Humans; D007194:India / Q000453:epidemiology; D008168:Lung / Q000473:pathology / Q000503:physiopathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D011009:Pneumoconiosis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D012129:Respiratory Function Tests
D003031:Coal; D004391:Dust