title: A device for feline head positioning and stabilization during magnetic resonance imaging.
abstract: Minimization of head movement and reproduction of standard head positions are essential for reliable brain functional magnetic resonance imaging. Devices for stabilization and alignment of feline preparations are not available currently. We describe a system that involves minimal surgery, allows for both acute and chronic atraumatic positioning, and has the potential to be used for unanesthetized animals. The device uses non-metallic materials and stabilizes the head by means of an apparatus that fixes the head with nylon screws and dental cement in the frontal sinuses. Application of the head-stabilizing device decreases head movements by more than a factor of ten. Anatomical images show that this device provides 3 dimensional head placement at a precision comparable to that of a stereotactic frame, i.e. within 1 mm.
authors.affiliation: Department of Neurobiology, University of California at Los Angeles, Los Angeles, CA 90095-1763, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Henderson
authors.forename: R C
authors.initials: RC
authors.lastname: Frysinger
authors.forename: P L
authors.initials: PL
authors.lastname: Yu
authors.forename: R
authors.initials: R
authors.lastname: Bandler
authors.forename: R M
authors.initials: RM
authors.lastname: Harper
mesh_terms: D000818:Animals; D002415:Cats; D004867:Equipment Design; D019416:Head Movements; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*