title: Scientific basis and regulatory aspects for the toxicology of plant protection products in the European Union.
abstract: Authorization of plant protection products/agrochemicals/pesticides in the European Union is done on the basis of their toxicological properties. This paper reviews the current legislation for placing an agrochemical on the market (ie a new substance or a existing active substance), and the toxicology studies needed for inclusion of a substance in any of the annexes of the Council Directive of the European Economic Community 91/414/ EEC. Risk analysis and its steps is discussed. The "threshold toxicity" employed to allow risk characterisation of plant protection products is described, such as acceptable daily intake, acceptable operator exposure level, acute reference dose, and maximum admissible concentration in water.
authors.affiliation: Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Anadón
authors.forename: M R
authors.initials: MR
authors.lastname: Martínez-Larrañaga
authors.forename: M A
authors.initials: MA
authors.lastname: Martínez
mesh_terms: D000383:Agriculture; D005060:Europe; D006801:Humans; D007391:International Cooperation; D010575:Pesticides / Q000633:toxicity*; D011050:Policy Making; D011634:Public Health; D011640:Public Policy; D012016:Reference Values; D018570:Risk Assessment; D014116:Toxicology / Q000331:legislation & jurisprudence*
chemical_list: D010575:Pesticides