The 'biodrug' concept: an innovative approach to therapy.
Cell engineering technology using recombinant microorganisms has created new opportunities in the development of innovative drugs. This article presents the use of living genetically engineered microorganisms, such as bacteria or yeasts, as a new delivery vehicle to the gastrointestinal tract. This 'biodrug' concept was demonstrated using recombinant Saccharomyces cerevisiae expressing the plant cytochrome P450 73A1. This enzyme provides a relevant model for potential therapeutic applications, such as 'biodetoxication' in the digestive environment. An artificial gastrointestinal tract simulating human digestion was chosen as a powerful tool to validate the biodrug concept. This approach offers a novel strategy for drug discovery and testing.
Blanquet
S
S
Equipe de Recherche Technologique Conception, Ingénierie et Développement de l'Aliment et du Médicament, Faculté de Pharmacie, 28 place Henri-Dunant, 63000 Clermont-Ferrand, France.
Marol-Bonnin
S
S
Beyssac
E
E
Pompon
D
D
Renaud
M
M
Alric
M
M
D001187:Artificial Organs; D001691:Biological Therapy / Q000639:trends*; D004064:Digestive System; D015316:Genetic Therapy / Q000639:trends*; D006801:Humans; D007777:Lactobacillaceae; D012441:Saccharomyces cerevisiae