title: [Large villous adenoma of the colon in carcinomatous transformation: colonic resection after endoscopic excision].
abstract: Large colonic villous adenomas are benign neoplasms capable of malignant transformation with a higher frequency than other adenomas. Such transformation often requires surgical therapy after endoscopic resection. The aim of the present study was to establish the indications for surgery in a series of 13 cases of large colonic villous adenomas initially submitted to endoscopic resection. The patients (8 males and 5 females; mean age; 62 years) were observed over the period 1993-2000. All endoscopic resections were performed using the piecemeal technique. In 7 cases there were 2 endoscopic sessions and in one case 3; a single case of post-endoscopic bleeding was treated conservatively. In 5 cases, endoscopic resection was deemed not to be radical and these patients were submitted to surgical resection. Histology on the surgical specimens revealed 2 cases of carcinoma (T1 and T2, respectively), confirmation of colonic villous adenoma in 2 cases and the presence of inflammatory tissue in 1 case. Among the patients treated with endoscopic resection alone one death occurred at two years due to lung and systemic metastases probably due to the malignant adenoma. After a review of the literature and on the basis of their own experience, the authors stress the importance of a combined pathological and endoscopic approach to establish when surgery is required.
authors.affiliation: Sezione di Chirurgia Generale II, Dipartimento di Scienze Chirurgiche e Trapianti d'Organo dell'Università di Cagliari.
authors.forename: G
authors.initials: G
authors.lastname: Pisano
authors.forename: C
authors.initials: C
authors.lastname: Zonza
authors.forename: E
authors.initials: E
authors.lastname: Erdas
authors.forename: M
authors.initials: M
authors.lastname: Pomata
authors.forename: G M
authors.initials: GM
authors.lastname: Daniele
mesh_terms: D018253:Adenoma, Villous / Q000473:pathology / Q000601:surgery*; D000368:Aged; D002471:Cell Transformation, Neoplastic; D003082:Colectomy; D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged