[Current views on the etiopathogenesis of preeclampsia].
OBJECTIVE
To present a review of literature and to present our experiences of patients with preeclampsia.


METHODS
Review article.


METHODS
Second Clinic of Gynecology and Obstetrics, Medical Faculty of the Safarik University and L. Pasteur's Hospital, Kosice, Slovak Republic.


METHODS
Compilation of data from scientific literature.


CONCLUSIONS
The etiology of preeclampsia is still unknown. The 4 hypotheses currently accepted are the placental ischemia hypothesis, genetic hypothesis, the immune maladaption and hypothesis of the imbalance between free oxygen radicals and scavengers in favor of oxidants. At the present is most popular the theory of oxidative stress, that lead to increased production of lipide peroxides, tromboxane A2 and decreased level of prostacyclin. This imbalance triggers endothelial dysfunction and its clinical manifestation. Scavenging antioxidants have protective effect in this process.
Homzová
M
M
II. gynekologicko-pôrodnícka klinika LF UPJS a Fakultnej nemocnice L. Pasteura, Kosice.
Ostró
A
A
D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy