Prions and protein inhibitors of proteinases: structural analogies and their consequences. III. Additive risk factor in transgenic technologies.
The article presents the risk factor connected with transgenous technologies. The probable risk is stipulated by a possibility to produce the proteins capable to initiate prion-conditioned neurodegenerative processes as a consequence of possible membrane folding of the recombinant protein portion.
Verevka
S V
SV
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv. verevka@biochem.kiev.ua
D000818:Animals; D051379:Mice; D008822:Mice, Transgenic; D018620:PrPSc Proteins / Q000737:chemistry*; D011480:Protease Inhibitors / Q000737:chemistry*; D011487:Protein Conformation; D012307:Risk Factors
D018620:PrPSc Proteins; D011480:Protease Inhibitors