QSAR studies on acylated histamine derivatives.
H(3)-receptor antagonists activity in terms of -log K(i) for a series of acylated histamine derivatives was modeled using topological indices, namely negentropy (N), molecular redundancy (MRI), and valence connectivity index ((m)x(v)) indices. Excellent results were obtained in multiple regression analysis upon the introduction of a dummy parameter (indicator parameter). Consistent increase in R(2)(A) value indicated that inspite of observed collinearity the proposed models are significant.
Agrawal
V K
VK
Department of Chemistry, A.P.S. University, -486 003, Rewa, India.
Khadikar
P V
PV
D000107:Acetylation; D000818:Animals; D006632:Histamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006633:Histamine Antagonists / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D021281:Quantitative Structure-Activity Relationship; D018100:Receptors, Histamine H3
D006633:Histamine Antagonists; D018100:Receptors, Histamine H3; D006632:Histamine