title: Minocycline hypersensitivity syndrome with hypotension mimicking septic shock.
abstract: Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. A serious but rare adverse effect caused by minocycline therapy is a hypersensitivity syndrome (HS), consisting of fever, skin eruption, and internal organ involvement that begins within 8 weeks of therapy initiation. We report a case of minocycline HS with unique features, namely, associated hypotension, and a rebound of the cutaneous eruption upon discontinuation of systemic steroids.
authors.affiliation: Department of Dermatology, University of Cincinnati, Cincinnati, Ohio, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Colvin
authors.forename: A P
authors.initials: AP
authors.lastname: Sheth
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis / Q000188:drug therapy; D000284:Administration, Oral; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005500:Follow-Up Studies; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects*; D018570:Risk Assessment; D012772:Shock, Septic / Q000139:chemically induced* / Q000175:diagnosis; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D008911:Minocycline