title: Diverticular disease and treatment with gastric acid inhibitors do not predispose to peritonitis of enteric origin in peritoneal dialysis patients.
abstract: OBJECTIVE
  Enteric peritonitis (EP) is an infrequent complication of peritoneal dialysis (PD), with severe consequences for peritoneal membrane viability and patient outcome. Factors such as diverticular disease and gastric acid inhibitors have been implicated in its appearance. We investigated several risk factors, including those mentioned below, that can influence the development of EP.
  
  
  METHODS
  Retrospective cross-sectional study.
  
  
  METHODS
  Tertiary-care public university hospital.
  
  
  METHODS
  Fifty-seven PD patients treated in our PD unit during August 1998.
  
  
  METHODS
  A barium enema was performed on 50 of the 57 patients (the remaining 7 patients refused it) in order to exclude the presence of diverticulosis. All episodes of peritonitis occurring in those patients, including EP, were registered. Enteric peritonitis was defined as that caused by gram-positive, gram-negative, or fungus micro-organisms that colonized the intestinal tract, excluding episodes secondary to genitourinary tract or peritoneal catheter exit-site infections.
  
  
  RESULTS
  Twenty-four patients showed diverticular disease in the barium enema, but only 5 of them (21%) had any EP episode. Five of the 26 patients with no diverticula (19%) had EP. Fifty-five episodes of peritonitis were reported in 21 patients; 15 episodes of EP (27.3% of all) developed in 11 patients. Seven of the 11 patients (64%) required peritoneal catheter removal and 3 of them (27%) finally were transferred to hemodialysis due to consequences of the EP episode. Logistic regression analysis did not find any of the independent variables analyzed (age, sex, time on PD, type of PD, peritoneal transport parameters, presence of polycystic kidney disease, constipation or diverticulosis, or treatment with gastric acid inhibitors, or phosphate-binding agents) to be risk factors for developing EP.
  
  
  CONCLUSIONS
  Neither diverticulosis nor treatment with gastric acid inhibitors seem to be risk factors for developing peritonitis of enteric origin in PD patients. This type of peritonitis has to be promptly identified and treated in order to diminish the high frequency of peritoneal catheter removal and PD dropout due to such episodes.
authors.affiliation: Nephrology Service, Hospital Universitario La Paz, Madrid, Spain. gpeso@hulp.insalud.es
authors.forename: G
authors.initials: G
authors.lastname: del Peso
authors.forename: M A
authors.initials: MA
authors.lastname: Bajo
authors.forename: L
authors.initials: L
authors.lastname: Gadola
authors.forename: I
authors.initials: I
authors.lastname: Millán
authors.forename: R
authors.initials: R
authors.lastname: Codoceo
authors.forename: O
authors.initials: O
authors.lastname: Celadilla
authors.forename: M J
authors.initials: MJ
authors.lastname: Castro
authors.forename: A
authors.initials: A
authors.lastname: Aguilera
authors.forename: F
authors.initials: F
authors.lastname: Gil
authors.forename: R
authors.initials: R
authors.lastname: Selgas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000863:Antacids / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000009:adverse effects; D003430:Cross-Sectional Studies; D004241:Diverticulum, Colon / Q000150:complications*; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D010538:Peritonitis / Q000209:etiology* / Q000382:microbiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000863:Antacids; D000897:Anti-Ulcer Agents