Isolation and structure elucidation of a new antifungal and antibacterial antibiotic produced by Streptomyces sp. 201.
An antibacterial and antifungal antibiotic was isolated from the culture filtrate of Streptomyces sp. 201, and its structure was determined as 2-methyl-heptyl isonicotinate by extensive use of NMR spectroscopy. The compound exhibited marked antimicrobial activity against Bacillus subtilis, Shigella sp., Klebsiella sp., E. coli, Proteus mirabilis, and the pathogenic fungi, Fusarium moniliforme, F. semitectum, F. oxysporum, F. solani and Rhizoctonia solani.
Bordoloi
G N
GN
Biochemistry Division and Natural Product Chemistry, Regional Research Laboratory (CSIR), Jorhat, Assam, India.
Kumari
B
B
Guha
A
A
Bordoloi
M
M
Yadav
R N
RN
Roy
M K
MK
Bora
T C
TC
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002855:Chromatography, Thin Layer; D005658:Fungi / Q000187:drug effects; D007538:Isoniazid / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000995:Antitubercular Agents; D007538:Isoniazid