Orally administered clonidine significantly reduces pain during injection of propofol.
We examined the analgesic effects of orally administered clonidine on pain induced by injection of propofol (Diprivan; 2,6-diisopropyl phenol). Female patients (n=81) were randomly allocated to one of two groups: oral clonidine (5.5 microg kg(-1)) followed by i.v. propofol and a control group given placebo followed by i.v. propofol. The median pain score in the group receiving clonidine, using a four-point scale (0=no pain, 1=minimal pain, 2=moderate pain, 3=severe pain) was 1 (0-2), significantly lower than in the control group [2 (1-3), median (25-75 percentiles), P<0.001].
Yoshikawa
T
T
Department of Anaesthesia, Hakujikai Memorial Hospital, Tokyo, Japan.
Wajima
Z
Z
Ogura
A
A
Inoue
T
T
Ogawa
R
R
D000284:Administration, Oral; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage*; D000328:Adult; D016009:Chi-Square Distribution; D003000:Clonidine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007267:Injections; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control*; D011292:Premedication; D015742:Propofol
D000316:Adrenergic alpha-Agonists; D003000:Clonidine; D015742:Propofol