On a possible new intracellular signal-system in rat gastric mucosa.
It is known that cAMP and cGMP, as an "intracellular second messenger system" play a significant role as a signal system, in the mechanism of action of anti-ulcerogenic (cytoprotective) drugs. According to our present, preliminary investigations it seems that during different experimental circumstances the gastric mucosal 3'-5'-cyclic-cytidine-mono-phosphate (cCMP) 3'-5'-cyclic-uridine-monophosphate and (cUMP) levels were changed--similarly to CAMP and cGMP--and these changes might be a possible indicator of a further, most probably secondary, signal- system role.
Balint
G A
GA
Laboratory of Clinical Pharmacology, Department of Psychiatry, New Clinics, Faculty of Medicine University of Szeged, GPO Box 427, H-6701 Szeged, Hungary. Balint@nepsy.szote.u-szeged.hu
Galfi
M
M
Rimanoczy
A
A
Falkay
G
G
Juhaaz
A
A
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D003563:Cyclic CMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D015232:Dinoprostone / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007425:Intracellular Membranes / Q000502:physiology*; D009712:Nucleotides, Cyclic / Q000378:metabolism; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000502:physiology*; D014542:Uridine Monophosphate / Q000378:metabolism
D006635:Histamine H2 Antagonists; D009712:Nucleotides, Cyclic; D003563:Cyclic CMP; C045338:cyclic 3',5'-uridine monophosphate; D011899:Ranitidine; D011464:Epoprostenol; D000242:Cyclic AMP; D014542:Uridine Monophosphate; D006152:Cyclic GMP; D015232:Dinoprostone