title: Alkylation of chiral alpha-hydroxy ketones derived from (1R)-(+)-camphor. An asymmetric variant of the classical acetylene route to carbonyl compounds.
abstract: [reaction: see text]. The asymmetric version of the traditional route for transforming acetylene into alpha-branched carbonyl compounds is now feasible for the first time. The method involves the temporary attachment of camphor to acetylene and gives a remarkably high diastereo- and enantioselectivity.
authors.affiliation: Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080-San Sebastián, Spain. qoppanic@sc.ehu.edu
authors.forename: C
authors.initials: C
authors.lastname: Palomo
authors.forename: M
authors.initials: M
authors.lastname: Oiarbide
authors.forename: A
authors.initials: A
authors.lastname: Mielgo
authors.forename: A
authors.initials: A
authors.lastname: González
authors.forename: J M
authors.initials: JM
authors.lastname: García
authors.forename: C
authors.initials: C
authors.lastname: Landa
authors.forename: A
authors.initials: A
authors.lastname: Lecumberri
authors.forename: A
authors.initials: A
authors.lastname: Linden