Intramolecular conjugate addition of alkenyl and aryl functions to enones initiated by lithium-iodine exchange.
[reaction: see text]. Treatment of each of the substrates 20-26, 29, and 46-48 with t-BuLi in THF, in the presence of HMPA and TMSCl, provides good-to-excellent yields of the intramolecular conjugate addition products 30-36, 37, and 49-51, respectively.
Piers
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Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1. epier@interchange.ubc.ca
Harrison
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Zetina-Rocha
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