Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.
A series of N(1)- and N(2)-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N(1)- and N(2)-propargylphenelzines (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties.
Ling
L
L
CV Technologies Inc., Edmonton Research Park, 9411-20 Ave., Edmonton, T6N 1E5, Alberta, Canada. linglei@cvtechnologies.com
Urichuk
L J
LJ
Sloley
B D
BD
Coutts
R T
RT
Baker
G B
GB
Shan
J J
JJ
Pang
P K
PK
D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry; D009638:Norepinephrine / Q000378:metabolism; D010624:Phenelzine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; C440368:N-propargylphenelzine; D018696:Neuroprotective Agents; D010624:Phenelzine; D009638:Norepinephrine