Profiling brain transcription: neurons learn a lesson from yeast.
The application of microarray technologies to the brain poses unique challenges, because of the complexity of the central nervous system and the availability of resources. Nevertheless, recent studies using DNA chips have made inroads into the molecular characterization of regional and functional brain units, the identification of developmental gene expression patterns, and the discovery of transcriptional differences associated with behavioral and neuropathological traits.
Cao
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Affymetrix Inc., 3380 Central Expressway, Santa Clara, CA 95051, USA. yanxiang_cao@affymetrix.com
Dulac
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D000818:Animals; D001921:Brain / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D004718:Saccharomycetales / Q000235:genetics; D014158:Transcription, Genetic / Q000502:physiology*