title: Species differences in [11C]clorgyline binding in brain.
abstract: [11C]Clorgyline selectively binds to MAO A in the human brain. This contrasts with a recent report that [11C]clorgyline (in contrast to other labeled MAO A inhibitors) is not retained in the rhesus monkey brain [4]. To explore this difference, we compared [11C]clorgyline in the baboon brain before and after clorgyline pretreatment and we also synthesized deuterium substituted [11C]clorgyline (and its nor-precursor) for comparison. [11C]Clorgyline was not retained in the baboon brain nor was it influenced by clorgyline pretreatment or by deuterium substitution, contrasting to results in humans. This suggests a species difference in the susceptibility of MAO A to inhibition by clorgyline and represents an unusual example of where the behavior of a radiotracer in the baboon brain does not predict its behavior in the human brain.
authors.affiliation: Brookhaven National Laboratory, Upton, New York 11973, USA. fowler@bnl.gov
authors.forename: J S
authors.initials: JS
authors.lastname: Fowler
authors.forename: Y S
authors.initials: YS
authors.lastname: Ding
authors.forename: J
authors.initials: J
authors.lastname: Logan
authors.forename: R R
authors.initials: RR
authors.lastname: MacGregor
authors.forename: C
authors.initials: C
authors.lastname: Shea
authors.forename: V
authors.initials: V
authors.lastname: Garza
authors.forename: R
authors.initials: R
authors.lastname: Gimi
authors.forename: N D
authors.initials: ND
authors.lastname: Volkow
authors.forename: G J
authors.initials: GJ
authors.lastname: Wang
authors.forename: D
authors.initials: D
authors.lastname: Schlyer
authors.forename: R
authors.initials: R
authors.lastname: Ferrieri
authors.forename: S J
authors.initials: SJ
authors.lastname: Gatley
authors.forename: D
authors.initials: D
authors.lastname: Alexoff
authors.forename: P
authors.initials: P
authors.lastname: Carter
authors.forename: P
authors.initials: P
authors.lastname: King
authors.forename: N
authors.initials: N
authors.lastname: Pappas
authors.forename: C D
authors.initials: CD
authors.lastname: Arnett
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000201:enzymology / Q000378:metabolism*; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D003010:Clorgyline / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D003903:Deuterium; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007202:Indicators and Reagents; D007553:Isotope Labeling; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000493:pharmacokinetics*; D010215:Papio; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D013045:Species Specificity; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D007202:Indicators and Reagents; D008996:Monoamine Oxidase Inhibitors; D019275:Radiopharmaceuticals; D003903:Deuterium; D008995:Monoamine Oxidase; D003010:Clorgyline