Genetically determined differences in the resistance to myocardial infarction in Wistar and August rats.
In intact August rats, the cardiac contractile function at rest was by 76% higher than in Wistar rats, while their hearts, both intact and after acute myocardial infarction, were more resistant to isometric load than the hearts of Wistar rats. Postinfarction mortality in August rats was 18% vs. 70% in Wistar rats. Adrenoreactivity of the myocardium in August rats was decreased compared to that in Wistar rats. These peculiarities can determine high resistance of August rats to myocardial infarction.
Belkina
L M
LM
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Saltykova
V A
VA
Pshennikova
M G
MG
D000818:Animals; D020022:Genetic Predisposition to Disease; D009200:Myocardial Contraction / Q000235:genetics; D009203:Myocardial Infarction / Q000235:genetics* / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000235:genetics / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013045:Species Specificity