[Gene protective effect of the short-chain derivative of Vitamin E under the action of alkylating compounds].
The gene protective effect of the short chain derivative of vitamin E was investigated in rats intoxicated with embichin and cyclophosphamide. Prophylactic administration of tocopherol derivative for 14 days promotes reduction of the genome and chromosome disturbances in marrow cells caused by this compounds. Correcting influence of tocopherol derivative depends on chemical structure and biologic peculiarities of the alkylating compound.
Bishovets'
T F
TF
Saifetdinova
G A
GA
Okhrimenko
V O
VO
Kovalenko
V M
VM
Donchenko
G I
GI
D000818:Animals; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology / Q000633:toxicity; D004249:DNA Damage / Q000187:drug effects*; D008466:Mechlorethamine / Q000633:toxicity; D051381:Rats; D024505:Tocopherols / Q000494:pharmacology; D014810:Vitamin E / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*
D016587:Antimutagenic Agents; D018906:Antineoplastic Agents, Alkylating; D014810:Vitamin E; D008466:Mechlorethamine; D003520:Cyclophosphamide; D024505:Tocopherols