Successful in vitro fertilization pregnancy after conservative management of endometrial cancer.
OBJECTIVE
To report a successful IVF pregnancy in an infertile couple after conservative treatment of endometrial cancer.


METHODS
Case report and literature review.


METHODS
University teaching hospital.


METHODS
A 29-year-old infertile white woman.


METHODS
Successful pregnancy after conservative management of endometrial cancer.


METHODS
Grade 1 endometrial adenocarcinoma diagnosed at hysteroscopy, followed by dilatation and curettage (D&C). On follow-up D&C, pathologic examination was normal after high-dose progesterone therapy. The patient subsequently underwent an IVF cycle with transfer of three blastocysts.


RESULTS
The patient delivered triplets by cesarean section. Laparoscopic-assisted vaginal hysterectomy and bilateral salpingo-oophorectomy was then done. No residual endometrial cancer was evident in the hysterectomy specimen, but a 1.1-cm cystic mixed endometrioid and clear cell-type adenocarcinoma was discovered in the left ovary. The patient is doing well after 3 cycles of chemotherapy; her CA-125 level is normal. The triplets are also doing well.


CONCLUSIONS
In carefully chosen situations, deferring surgery in infertile patients with endometrial cancer may be a viable option permitting subsequent successful pregnancy.
Pinto
A B
AB
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Gopal
M
M
Herzog
T J
TJ
Pfeifer
J D
JD
Williams
D B
DB
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016889:Endometrial Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007045:Hysterectomy, Vaginal; D016609:Neoplasms, Second Primary / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D011247:Pregnancy; D013997:Time Factors; D016896:Treatment Outcome