A point mutation in CD45 may be associated with an increased risk of HIV-1 infection.
The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Here we show that abnormal CD45 splicing caused by a C77G transversion in exon A of the gene encoding CD45 (PTPRC) is associated with increased susceptibility to HIV-1 infection.
Tchilian
E Z
EZ
The Edward Jenner Institute for Vaccine Research, Compton, UK.
Wallace
D L
DL
Dawes
R
R
Imami
N
N
Burton
C
C
Gotch
F
F
Beverley
P C
PC
D017398:Alternative Splicing; D005091:Exons / Q000235:genetics; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D015497:HIV-1; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics* / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology; D017354:Point Mutation
D017493:Leukocyte Common Antigens