Lung transplantation in interstitial lung disease.
Interstitial lung disease is a heterogeneous group of illnesses, some of which may progress to a fibrosing stage and cause respiratory failure. For selected candidates, lung transplantation is the ultimate therapeutic option. We review data on lung transplantation for various interstitial lung diseases. We address indications, procedures, and outcomes for patients undergoing transplantation. Unique issues affecting morbidity, mortality, and recurrence of disease are discussed. We review the literature of transplantation for specific interstitial lung diseases and the outcomes of transplantation for interstitial lung diseases. Candidates with idiopathic pulmonary fibrosis experience high mortality on the waiting list, but derive significant survival benefit from lung transplantation. Recurrence is reported for several interstitial lung diseases after lung transplantation. Survival with lung transplantation for interstitial lung diseases is comparable with that attained in recipients with other indications. Lung transplantation is a well-tolerated, effective therapy for respiratory failure in interstitial lung disease.
Sulica
R
R
Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.
Teirstein
A
A
Padilla
M L
ML
D006646:Histiocytosis, Langerhans-Cell / Q000601:surgery; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000401:mortality / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods*; D018192:Lymphangioleiomyomatosis / Q000601:surgery; D009752:Nutritional Status; D010024:Osteoporosis / Q000209:etiology; D011300:Preoperative Care; D011788:Quality of Life; D012008:Recurrence; D012507:Sarcoidosis / Q000601:surgery; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome