title: The effect on adipose tissue blood flow of isoenergetic meals containing different amounts and types of fat.
abstract: OBJECTIVE
  To investigate the factors regulating the increase in adipose tissue blood flow following meals.
  
  
  METHODS
  Eight subjects were fed three isoenergetic meals; two high-fat meals rich in either saturated or polyunsaturated fatty acids and one low-fat, high-carbohydrate meal.
  
  
  METHODS
  Blood samples were taken and adipose tissue blood flow was measured before and for 6 h after the meal. Plasma glucose, insulin, non-esterified fatty acid, total and chylomicron-triacylglycerol and catecholamine concentrations were measured.
  
  
  RESULTS
  Adipose tissue blood flow rose to a peak after all three meals (P<0.05 for each). The three meals stimulated adipose tissue blood flow at similar times. There was a marked and statistically significant similarity in the time course of changes in blood flow and insulin concentrations. In contrast, noradrenaline concentrations peaked later than adipose tissue blood flow (P=0.014).
  
  
  CONCLUSIONS
  Adipose tissue blood flow may be 'carbohydrate-stimulated' rather than 'fat-stimulated', with insulin having a vasodilatory role in adipose tissue as in skeletal muscle.
authors.affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK.
authors.forename: L K
authors.initials: LK
authors.lastname: Summers
authors.forename: J
authors.initials: J
authors.lastname: Callow
authors.forename: J S
authors.initials: JS
authors.lastname: Samra
authors.forename: I A
authors.initials: IA
authors.lastname: Macdonald
authors.forename: D R
authors.initials: DR
authors.lastname: Matthews
authors.forename: K N
authors.initials: KN
authors.lastname: Frayn
mesh_terms: D000273:Adipose Tissue / Q000098:blood supply*; D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood; D002914:Chylomicrons / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D002914:Chylomicrons; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides