title: Antifilaggrin antibodies in early rheumatoid arthritis may predict radiological progression.
abstract: OBJECTIVE
  To elucidate the possibility that autoantibodies to filaggrin, detected in patients with early RA (having a disease duration of not more than one year), may predict joint destruction assessed after five years of observation.
  
  
  METHODS
  This is a 5 yr extension of a previous study (1) of 112 consecutive patients with early RA. Serum antifilaggrin autoantibodies were detected by immunoblotting (AFA) and by indirect immunofluorescence ("AKA"). DAS28, pain on a VAS. HAQ, and CRP were measured. Plain X-ray films were taken from hands and forefeet and a Larsen score was calculated.
  
  
  RESULTS
  Ninety-two of the original 112 patients had baseline X-rays available and constituted the study material. At 5 year follow-up, 67 of these 92 have been assessed and for 63 of these X-rays were available. For the whole patient material, significant radiological progression, measured by Larsen scores, occurred while disease activity and function (pain VAS, DAS28, CRP, and HAQ) improved significantly over five years. The groups of patients having AFA or "AKA" at baseline had significantly (p=0.006 and p<0.001, respectively) higher Larsen scores five years later than the groups without these antibodies. No clear relation of these antibodies to disease activity or function was demonstrated, except that the group of patients with "AKA" had significantly higher median CRP (p=0,003) after five years.
  
  
  CONCLUSIONS
  The present study shows that antifilaggrin autoantibodies may predict radiological progression. The prognostic value of these antibodies will be further evaluated in relation to other potential markers in a larger patient material.
authors.affiliation: Department of Medicine, Helsingborg lasarett AB, Sweden. kristina.forslind@helsingborgslasarett.se
authors.forename: K
authors.initials: K
authors.lastname: Forslind
authors.forename: C
authors.initials: C
authors.lastname: Vincent
authors.forename: G
authors.initials: G
authors.lastname: Serre
authors.forename: B
authors.initials: B
authors.lastname: Svensson
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology / Q000503:physiopathology; D001175:Arthrography; D001323:Autoantibodies / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D000091344:Filaggrin Proteins; D019084:Fluorescent Antibody Technique, Indirect; D005528:Foot / Q000000981:diagnostic imaging; D006225:Hand / Q000000981:diagnostic imaging; D006304:Health Status; D006801:Humans; D015151:Immunoblotting; D007381:Intermediate Filament Proteins / Q000276:immunology*; D007596:Joints; D007633:Keratins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology; D012217:Rheumatoid Factor / Q000097:blood; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D001323:Autoantibodies; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D007633:Keratins; D002097:C-Reactive Protein; D012217:Rheumatoid Factor