Minocycline hypersensitivity syndrome with hypotension mimicking septic shock.
Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. A serious but rare adverse effect caused by minocycline therapy is a hypersensitivity syndrome (HS), consisting of fever, skin eruption, and internal organ involvement that begins within 8 weeks of therapy initiation. We report a case of minocycline HS with unique features, namely, associated hypotension, and a rebound of the cutaneous eruption upon discontinuation of systemic steroids.
Colvin
J H
JH
Department of Dermatology, University of Cincinnati, Cincinnati, Ohio, USA.
Sheth
A P
AP
D000152:Acne Vulgaris / Q000175:diagnosis / Q000188:drug therapy; D000284:Administration, Oral; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005500:Follow-Up Studies; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects*; D018570:Risk Assessment; D012772:Shock, Septic / Q000139:chemically induced* / Q000175:diagnosis; D013577:Syndrome; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D008911:Minocycline