Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity.
Three new quinoline alkaloids, 2-acetylevolitrine (1), 2-acetylpteleine (2), and semecarpifoline (3), along with 26 known compounds were isolated from the root bark of Melicope semecarpifolia. The structures of 1-3 were elucidated by means of spectral analysis. In addition, (2S)-(--)-7,8-dimethoxyplatydesmine (4), cis-(+)-7,8-dimethoxymyrtopsine (5), and (3R)-(--)-8,9-dimethoxygeibalansine (6) were isolated as new natural products. Several of these isolates were determined as exhibiting significant antiplatelet aggregation activities in vitro.
Chen
I S
IS
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China. m635013@cc.kmu.edu.tw
Chen
H F
HF
Cheng
M J
MJ
Chang
Y L
YL
Teng
C M
CM
Tsutomu
I
I
Chen
J J
JJ
Tsai
I L
IL
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D002855:Chromatography, Thin Layer; D003094:Collagen / Q000494:pharmacology; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D027821:Rutaceae / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013624:Taiwan; D013917:Thrombin / Q000494:pharmacology
C438072:2-acetylevolitrine; C438075:2-acetylpteleine; C438074:7,8-dimethoxymyrtopsine; C438077:7,8-dimethoxyplatydesmine; C438073:8,9-dimethoxygeibalansine; D000470:Alkaloids; D006575:Heterocyclic Compounds, 3-Ring; D010975:Platelet Aggregation Inhibitors; D011804:Quinolines; C438076:semecarpifoline; D016718:Arachidonic Acid; D003094:Collagen; D013917:Thrombin