Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitis.
Conditions consistent with tolerance or immunoregulation have been observed in experimental Candida albicans vaginal infections. The present study investigated the role of gamma/delta T cells in experimental vaginal candidiasis. Results showed that T-cell receptor delta-chain-knockout mice had significantly less vaginal fungal burden when compared to wild-type mice, suggesting an immunoregulatory role for gamma/delta T cells in Candida vaginitis.
Wormley
F L
FL
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Steele
C
C
Wozniak
K
K
Fujihashi
K
K
McGhee
J R
JR
Fidel
P L
PL
D000818:Animals; D002177:Candidiasis / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009589:Nitrogen Oxides / Q000378:metabolism; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014627:Vaginitis / Q000276:immunology*
D009589:Nitrogen Oxides; D016692:Receptors, Antigen, T-Cell, gamma-delta