title: [New in vitro analysis tested: bleeding time is still the best method for evaluation of primary hemostasis].
abstract: The need is great for a simple, cheap and readily accessible method for the evaluation of primary hemostasis in work-ups at both out-patient clinics and units caring for surgical or intensive care patients. PFA-100 is a recently introduced instrument for in vitro testing of platelet function. We report experiences from Stockholm, Gothenburg and Malmo of PFA-100 measurements performed on samples from healthy controls and from patients with von Willebrand disease or platelet disorders. It is shown that the PFA-100 system has a high sensitivity for von Willebrands disease, while the sensitivity for hereditary platelet dysfunction is low. In its present design this new device could not replace the template bleeding time as a screening test for primary hemostasis.
authors.affiliation: Avdelningen för klinisk kemi och farmakologi, Akademiska sjukhuset, Uppsala. peter.ridefelt@medsci.uu.se
authors.forename: P
authors.initials: P
authors.lastname: Ridefelt
authors.forename: N
authors.initials: N
authors.lastname: Egberg
authors.forename: A
authors.initials: A
authors.lastname: Hillarp
authors.forename: S
authors.initials: S
authors.lastname: Lethagen
authors.forename: L
authors.initials: L
authors.lastname: Tengborn
mesh_terms: D001760:Bleeding Time / Q000379:methods / Q000592:standards; D001791:Blood Platelet Disorders / Q000097:blood* / Q000175:diagnosis; D006487:Hemostasis; D006801:Humans; D010979:Platelet Function Tests / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D012680:Sensitivity and Specificity