title: [Meningococcal disease in Spain: seasonal nature and recent changes].
abstract: BACKGROUND
  In this study we built a time series model in the time domain based on the cases of meningococcal disease declared every four weeks in Spain between 1972 and 1998 With the model we analyzed the incidence of the disease and examined whether an epidemic really took place at the beginning of 1997, or whether the values were in the range of expectations. At this time there was widespread social alarm in Spain, because there was considered to be an outbreak of meningitis. We also examined whether the incidence of the disease diminished during 1997 following the measures introduced by the Comisión Interterritorial del Sistema Nacional de Salud.
  
  
  METHODS
  The data on the incidence of the meningococcal disease in Spain were obtained from the Boletín Epidemiológico Semanal, published by the Instituto de Salud Carlos III, declared from 1972 to 1998 and grouped every four weeks. The method corresponds to the time series model in the domain of time: the Box-Jenkins method.
  
  
  RESULTS
  In order to explain the behaviour of the disease during the years of the study we chose a model ARIMA(0,1,1) (0,1,1)13 that shows annual seasonal behaviour, with higher incidence in the winter and the beginning of spring, and lower incidence in summer. An intervention analysis showed that in March 1996 there was a level shift in the incidence of the illness. This lasted until September 1997, at which time the incidence returned to pre-1996.
  
  
  CONCLUSIONS
  The measures of sanitary monitoring against the meningitis in the months of greater incidence, winter and beginning of spring must be intensified. Between spring 1996 and autumn 1997 the incidence of meningitis increased. Thereafter, until the end of 1998, there was a significant decrease in incidence, attributable to the performance of the health authorities.
authors.affiliation: Departamento de Estadística. Facultad de Biología. Universidad de Barcelona.
authors.forename: J A
authors.initials: JA
authors.lastname: Sánchez
authors.forename: L
authors.initials: L
authors.lastname: Cano
authors.forename: M
authors.initials: M
authors.lastname: Ríos
mesh_terms: D006801:Humans; D015994:Incidence; D008585:Meningitis, Meningococcal / Q000453:epidemiology*; D012621:Seasons; D013030:Spain / Q000453:epidemiology