title: [Diabetic foot ulcers: anti-infectious strategies].
abstract: Infection is a common problem in diabetic patients with foot ulcers. The diagnosis of infection is not always easy to establish, but must be made for proper therapeutic decision making. In addition to local care, search for arteriopathy and strict control of blood glucose, treatment of infected foot ulcers requires an appropriate anti-infectious strategy. We developed diagnostic and therapeutic decisional algorithms from data available in the literature in order to establish a management strategy for different clinical situations. The fundamental role of clinical assessment is underlined and the different causal microorganisms are recalled, together with the anti-microbial activity and bone concentrations of the main antibiotics used. An optimal anti-infection work-up can undoubtedly significantly reduce the number of amputations in diabetic patients.
authors.affiliation: Service de Gériatrie, Hôpital Européen Georges-Pompidou, 20, rue Leblanc, 75015, Paris, France. dcsomme@free.fr
authors.forename: D
authors.initials: D
authors.lastname: Somme
authors.forename: J L
authors.initials: JL
authors.lastname: Reny
authors.forename: J L
authors.initials: JL
authors.lastname: Mainardi
mesh_terms: D000465:Algorithms; D000671:Amputation, Surgical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000145:classification / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D001786:Blood Glucose / Q000032:analysis; D003131:Combined Modality Therapy; D003646:Debridement; D003663:Decision Trees; D017719:Diabetic Foot / Q000145:classification / Q000150:complications* / Q000378:metabolism; D004351:Drug Resistance; D006801:Humans; D017053:Infection Control / Q000379:methods*; D008826:Microbial Sensitivity Tests; D018579:Patient Selection; D011379:Prognosis; D012720:Severity of Illness Index; D017592:Skin Care / Q000379:methods; D014946:Wound Infection / Q000145:classification / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D001786:Blood Glucose