title: [Ischemia-reperfusion].
abstract: IMPORTANCE OF ISCHEMIA-REPERFUSION LESIONS: After transplantation, ischemia-reperfusion lesions are associated with an increased risk of acute rejection, late recovery of liver function, or chronic graft dysfunction. In all, about 20% of the grafts are lost. The importance of prevention is evident. HEME-OXYGENASE: It has been shown that heme-oxygenase, an anti-oxidant reducing apoptosis, reduces the extent of ischemia-reperfusion lesions after liver, heart, kidney or Langerhans islet transplantation. OTHER COMPOUNDS WITH INTERESTING PROPERTIES: Other compounds also have interesting properties for preventing ischemia-reperfusion lesions: a specific metallo-protease inhibitor, L-arginine, a selective agonist of the PGE1 receptor, estrogens, low-dose cyclosporine, and certain immunosuppressors (FTY 720, anti CD28, anti B7-1), and rPSGL-Ig ligand.
authors.affiliation: CHU de Nice.
authors.forename: R
authors.initials: R
authors.lastname: Cursio
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D006419:Heme Oxygenase (Decyclizing) / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D061965:Matrix Metalloproteinase Inhibitors; D008775:Methylprednisolone / Q000009:adverse effects; D015427:Reperfusion Injury / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D061965:Matrix Metalloproteinase Inhibitors; D006419:Heme Oxygenase (Decyclizing); D008775:Methylprednisolone