title: A radiation hybrid map of mouse genes.
abstract: A comprehensive gene-based map of a genome is a powerful tool for genetic studies and is especially useful for the positional cloning and positional candidate approaches. The availability of gene maps for multiple organisms provides the foundation for detailed conserved-orthology maps showing the correspondence between conserved genomic segments. These maps make it possible to use cross-species information in gene hunts and shed light on the evolutionary forces that shape the genome. Here we report a radiation hybrid map of mouse genes, a combined project of the Whitehead Institute/Massachusetts Institute of Technology Center for Genome Research, the Medical Research Council UK Mouse Genome Centre, and the National Center for Biotechnology Information. The map contains 11,109 genes, screened against the T31 RH panel and positioned relative to a reference map containing 2,280 mouse genetic markers. It includes 3,658 genes homologous to the human genome sequence and provides a framework for overlaying the human genome sequence to the mouse and for sequencing the mouse genome.
authors.affiliation: Center for Genome Research, Whitehead Institute/Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. tjhudson@med.mcgill.ca
authors.forename: T J
authors.initials: TJ
authors.lastname: Hudson
authors.forename: D M
authors.initials: DM
authors.lastname: Church
authors.forename: S
authors.initials: S
authors.lastname: Greenaway
authors.forename: H
authors.initials: H
authors.lastname: Nguyen
authors.forename: A
authors.initials: A
authors.lastname: Cook
authors.forename: R G
authors.initials: RG
authors.lastname: Steen
authors.forename: W J
authors.initials: WJ
authors.lastname: Van Etten
authors.forename: A B
authors.initials: AB
authors.lastname: Castle
authors.forename: M A
authors.initials: MA
authors.lastname: Strivens
authors.forename: P
authors.initials: P
authors.lastname: Trickett
authors.forename: C
authors.initials: C
authors.lastname: Heuston
authors.forename: C
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authors.lastname: Davison
authors.forename: A
authors.initials: A
authors.lastname: Southwell
authors.forename: R
authors.initials: R
authors.lastname: Hardisty
authors.forename: A
authors.initials: A
authors.lastname: Varela-Carver
authors.forename: A R
authors.initials: AR
authors.lastname: Haynes
authors.forename: P
authors.initials: P
authors.lastname: Rodriguez-Tome
authors.forename: H
authors.initials: H
authors.lastname: Doi
authors.forename: M S
authors.initials: MS
authors.lastname: Ko
authors.forename: J
authors.initials: J
authors.lastname: Pontius
authors.forename: L
authors.initials: L
authors.lastname: Schriml
authors.forename: L
authors.initials: L
authors.lastname: Wagner
authors.forename: D
authors.initials: D
authors.lastname: Maglott
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
authors.forename: E S
authors.initials: ES
authors.lastname: Lander
authors.forename: G
authors.initials: G
authors.lastname: Schuler
authors.forename: P
authors.initials: P
authors.lastname: Denny
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D020224:Expressed Sequence Tags; D016678:Genome; D006822:Hybrid Cells / Q000528:radiation effects*; D051379:Mice