Vascular disease in younger-onset diabetes: comparison of European, Asian and American Indian cohorts of the WHO Multinational Study of Vascular Disease in Diabetes.
OBJECTIVE
This study compared the incidence of vascular disease in subjects with younger-onset diabetes from different ethnic groups.


METHODS
The incidence of vascular disease endpoints has been studied in a sub-group (n = 994) of participants of the World Health Organization Multinational Study of Vascular Disease in Diabetes (WHO MSVDD) who had younger-onset diabetes (diagnosed before the age of 30 years). The study participants have been divided into European (n = 631), Asian (n = 84) and American Indian (n = 91) cohorts.


RESULTS
For Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus, American Indian men had a higher incidence of lower-extremity amputation and renal failure than the other cohorts, whereas European women had a higher incidence of angina than other cohorts. American Indians also had a higher incidence of any retinopathy, clinical proteinuria and albuminuria than the European and Asian cohorts.


CONCLUSIONS
This study confirms the high burden of large and small-vessel disease complications manifest in American Indian people with younger-onset diabetes.
Lee
E T
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Centre for American Indian Health Research and Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Centre, Oklahoma City 73190, USA.
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Bennett
P H
PH
Keen
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D000328:Adult; D000671:Amputation, Surgical / Q000706:statistics & numerical data; D000787:Angina Pectoris / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D003928:Diabetic Nephropathies / Q000453:epidemiology; D003930:Diabetic Retinopathy / Q000453:epidemiology; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007198:Indians, North American; D007391:International Cooperation; D007866:Leg / Q000601:surgery; D008297:Male; D051437:Renal Insufficiency / Q000453:epidemiology; D012737:Sex Factors; D014481:United States / Q000453:epidemiology; D014944:World Health Organization