Rosacea: current thoughts on origin.
Rosacea is a clinical pattern beginning and evolving in the genetically susceptible individual in response to a host of exposures. It produces a variety of clinical presentations, which vary over time and with age. Recently, many specific mediators of rosacea development have been described. A primary genetic cause for rosacea is suggested as single genes often control such mediators: enzymes, neuroendocrine transmitters, and cytokines are found in pathways to rosacea signs and symptoms. Currently, neither a specific cause nor a laboratory indicator of rosacea has been suggested. However, broadening interest in rosacea portends future increase in knowledge.
Bamford
J T
JT
Department of Family Practice and Community Health, University of Minnesota-Duluth Medical School, MN, USA. Jbamford@smdc.org
D016207:Cytokines; D005145:Face / Q000098:blood supply; D016481:Helicobacter Infections / Q000150:complications; D006801:Humans; D012393:Rosacea / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications; D014466:Ultraviolet Rays / Q000009:adverse effects
D016207:Cytokines