Synthesis and chromatography of [CpRu]+-complexed bastadin precursors.
The eastern and western diaryl ether portions of the macrocyclic bastadins, natural products from the marine sponge Ianthella sp., have been assembled as [CpRu]+ complexes. In an HPLC study, aminopropyl-functionalised silica was found as a very suitable stationary phase for the chromatographic separation of the different cationic ruthenium sandwich complexes. It is now possible for the first time to effectively monitor and purify [CpRu]+ complexes and to carry them through several synthetic steps.
Leone-Stumpf
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Pharmazeutisch-chemisches Institut der Universität, Heidelberg, Germany.
Lindel
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D005459:Fluorides / Q000737:chemistry*; D055768:Halogenated Diphenyl Ethers; D007769:Lactams; D010455:Peptides; D010647:Phenyl Ethers / Q000138:chemical synthesis*; D010710:Phosphates / Q000737:chemistry*; D011161:Porifera; D012428:Ruthenium; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D055768:Halogenated Diphenyl Ethers; D007769:Lactams; D010455:Peptides; D010647:Phenyl Ethers; D010710:Phosphates; C012980:fluorophosphate; D014443:Tyrosine; C105188:bastadin 5; D012428:Ruthenium; D005459:Fluorides