Unresectable primary tumor of head and neck: does neck dissection combined with chemoradiotherapy improve survival?
A study regarding patients with primary and previously untreated advanced histologically proven squamous cell carcinoma of the head and neck was performed to compare two treatment modalities: neck dissection followed by chemoradiotherapy (Group I) versus chemoradiotherapy alone (Group II). Fifty-four patients were randomly chosen to receive Group I or II treatment. Our results demonstrate that Group I treatment has a higher and statistically significant disease-specific survival rate. We suggest that an association of neck dissection plus chemoradiotherapy can be useful in the event of unresectable advanced carcinomas.
Carinci
F
F
E.N.T. Clinic, University of Ferrara, Italy. crc@unife.it
Cassano
L
L
Farina
A
A
Pelucchi
S
S
Calearo
C
C
Modugno
V
V
Nielsen
I
I
Api
P
P
Pastore
A
A
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007262:Infusions, Intravenous; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000601:surgery; D009367:Neoplasm Staging; D016016:Proportional Hazards Models
D002945:Cisplatin; D005472:Fluorouracil