title: A comparison of modelling techniques used to characterise oxygen uptake kinetics during the on-transient of exercise.
abstract: We compared estimates for the phase 2 time constant (tau) of oxygen uptake (VO2) during moderate- and heavy-intensity exercise, and the slow component of VO2 during heavy-intensity exercise using previously published exponential models. Estimates for tau and the slow component were different (P < 0.05) among models. For moderate-intensity exercise, a two-component exponential model, or a mono-exponential model fitted from 20 s to 3 min were best. For heavy-intensity exercise, a three-component model fitted throughout the entire 6 min bout of exercise, or a two-component model fitted from 20 s were best. When the time delays for the two- and three-component models were equal the best statistical fit was obtained; however, this model produced an inappropriately low DeltaVO2/DeltaWR (WR, work rate) for the projected phase 2 steady state, and the estimate of phase 2 tau was shortened compared with other models. The slow component was quantified as the difference between VO2 at end-exercise (6 min) and at 3 min (DeltaVO2 (6-3 min)); 259 ml x min(-1)), and also using the phase 3 amplitude terms (truncated to end-exercise) from exponential fits (409-833 ml x min(-1)). Onset of the slow component was identified by the phase 3 time delay parameter as being of delayed onset approximately 2 min (vs. arbitrary 3 min). Using this delay DeltaVO2 (6-2 min) was approximately 400 ml x min(-1). Use of valid consistent methods to estimate tau and the slow component in exercise are needed to advance physiological understanding.
authors.affiliation: The Centre for Activity and Ageing, School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7.
authors.forename: C
authors.initials: C
authors.lastname: Bell
authors.forename: D H
authors.initials: DH
authors.lastname: Paterson
authors.forename: J M
authors.initials: JM
authors.lastname: Kowalchuk
authors.forename: J
authors.initials: J
authors.lastname: Padilla
authors.forename: D A
authors.initials: DA
authors.lastname: Cunningham
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D010101:Oxygen Consumption