Eph receptors tingle the spine.
During the development of excitatory synapses, molecules cluster on dendrites to form postsynaptic densities, and specialized structures known as spines appear. EphB2 is demonstrated to control this process by associating with and phosphorylating a key postsynaptic molecule, syndecan-2, thereby initiating the maturation of dendritic spines.
Henkemeyer
M
M
Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Frisén
J
J
D003712:Dendrites / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011509:Proteoglycans / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D036183:Receptor, EphB2; D053669:Syndecan-2
D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D011509:Proteoglycans; C508245:SDC2 protein, human; D053669:Syndecan-2; D020794:Receptor Protein-Tyrosine Kinases; D036183:Receptor, EphB2