Patients' values for health states associated with hepatitis C and physicians' estimates of those values.
OBJECTIVE
Hepatitis C is the leading cause of chronic hepatitis in the United States. Little information is available regarding how persons with hepatitis C view health with their disease. We studied patients' perceptions about the value of hepatitis C health states and evaluated whether physicians understand their patients' perspectives about this disease.


METHODS
A total of 50 consecutive persons with hepatitis C were surveyed when they presented as new patients to a hepatology practice. Subjects provided utility assessments (preference values) for five hepatitis C health states and for treatment side effects. They also stated their threshold for accepting antiviral therapy. Five hepatologists used the same scales to estimate their patients' responses.


RESULTS
On average, patients believed that hepatitis C without symptoms was associated with an 11% reduction in preference value from that of life without infection, and the most serious condition (severe symptoms, cirrhosis) was believed to carry a 73% decrement. Patients judged the side effects of antiviral therapy quite unfavorably, and their median stated threshold for accepting treatment was a cure rate of 80%. Physicians' estimates were not significantly associated with patients' preference values for hepatitis C health states, treatment side effects, or with patients' thresholds for accepting treatment. In multivariate analysis, patients' stated thresholds for taking treatment were significantly associated with their decisions regarding therapy (beta = -2.72+/-1.21, p = 0.025).


CONCLUSIONS
There was little agreement between patients' preference values about hepatitis C and their physicians' estimates of those values. Utility analysis could facilitate shared decision making about hepatitis C.
Cotler
S J
SJ
Department of Medicine, RUSH-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.
Patil
R
R
McNutt
R A
RA
Speroff
T
T
Banaad-Omiotek
G
G
Ganger
D R
DR
Rosenblate
H
H
Kaur
S
S
Cotler
S
S
Jensen
D M
DM
D000328:Adult; D005260:Female; D006304:Health Status; D006526:Hepatitis C / Q000188:drug therapy / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010820:Physicians; D012720:Severity of Illness Index