title: Porins from Salmonella enterica serovar Typhimurium induce TNF-alpha, IL-6 and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms.
abstract: Lipopolysaccharide (LPS) of Gram-negative bacteria and several surface components of Gram-positive bacteria utilize CD14 and CD11a/18 as cellular receptors to induce expression and release of cytokines. Of the surface components of Gram-negative bacteria, porins exhibit a biological activity similar to that of LPS. The results in this paper show that the mechanism of stimulation by porins of THP-1 cells enriched in CD14 receptor after treatment with 1,25-dihydroxyvitamin D(3) (vitamin D(3)) is independent of this receptor, but is partially dependent on CD11a/18 integrins.
authors.affiliation: Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Larghetto S. Aniello a Caponapoli n 2, 80138 Naples, Italy1.
authors.forename: Marilena
authors.initials: M
authors.lastname: Galdiero
authors.affiliation: Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Larghetto S. Aniello a Caponapoli n 2, 80138 Naples, Italy1.
authors.forename: Marina
authors.initials: M
authors.lastname: D'Isanto
authors.affiliation: Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Larghetto S. Aniello a Caponapoli n 2, 80138 Naples, Italy1.
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Vitiello
authors.affiliation: Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Larghetto S. Aniello a Caponapoli n 2, 80138 Naples, Italy1.
authors.forename: Emiliana
authors.initials: E
authors.lastname: Finamore
authors.affiliation: Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Larghetto S. Aniello a Caponapoli n 2, 80138 Naples, Italy1.
authors.forename: Lucia
authors.initials: L
authors.lastname: Peluso
authors.affiliation: Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Larghetto S. Aniello a Caponapoli n 2, 80138 Naples, Italy1.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Galdiero
mesh_terms: D018821:CD18 Antigens / Q000378:metabolism*; D002460:Cell Line; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D018950:Lipopolysaccharide Receptors / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism*; D009000:Monocytes / Q000276:immunology; D018272:Porins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D012486:Salmonella typhimurium / Q000276:immunology / Q000502:physiology*; D012703:Serotyping; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018821:CD18 Antigens; D016207:Cytokines; D007375:Interleukin-1; D016209:Interleukin-8; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D016169:Lymphocyte Function-Associated Antigen-1; D018272:Porins; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha