title: Association between laparoscopic abdominal surgery and postoperative symptoms of raised intracranial pressure.
abstract: Animal models have illustrated that a carbon dioxide (CO(2)) pneumoperitoneum can cause a rise in intracranial pressure (ICP). This study investigated key symptoms and signs of raised ICP in 39 patients after laparoscopic abdominal surgery and compared them with a control group of 33 patients after open operations. The findings show that the incidence of headache and nausea was significantly higher in the laparoscopic group than in the control subjects. End-tidal CO(2) levels were recorded, and no significant difference was found between patients and control subjects. We conclude that these results could be explained by raised intracranial pressure exacerbated by the CO(2) pneumoperitoneum, and that this effect is not mediated by raised expiratory CO(2) levels intraoperatively.
authors.affiliation: Department of Surgery, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, Scotland.
authors.forename: S J
authors.initials: SJ
authors.lastname: Cooke
authors.forename: S
authors.initials: S
authors.lastname: Paterson-Brown
mesh_terms: D002245:Carbon Dioxide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D006261:Headache / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D019586:Intracranial Hypertension / Q000453:epidemiology / Q000209:etiology*; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D009325:Nausea / Q000453:epidemiology / Q000209:etiology; D010313:Partial Pressure; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects / Q000379:methods*; D012119:Respiration / Q000187:drug effects
chemical_list: D002245:Carbon Dioxide