title: Surface plasmon resonance: towards an understanding of the mechanisms of biological molecular recognition.
abstract: With the introduction of new instruments and improved sensor chip chemistries, surface plasmon resonance (SPR) is finding new applications for molecular interaction studies. Easy access to high-quality kinetic and thermodynamic data for macromolecular binding events is providing insights into the fundamental mechanisms of molecular recognition. Progress is being made to allow larger-scale interaction studies. In addition, combining SPR with other analytical methods is enabling SPR-based analysis of interaction proteomics.
authors.affiliation: The Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. jim@biop.ox.ac.uk
authors.forename: J M
authors.initials: JM
authors.lastname: McDonnell
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D002462:Cell Membrane / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D011485:Protein Binding; D012015:Reference Standards; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods*
chemical_list: D007136:Immunoglobulins; D008024:Ligands; D004815:Epidermal Growth Factor