[Association of apolipoprotein E gene polymorphism with early-onset coronary heart disease and its effect on plasma lipid levels].
OBJECTIVE
To detect the association of apolipoprotein E(apoE) gene polymorphism with early-onset coronary heart disease(CHD) and to evaluate the effect of apoE gene polymorphism on plasma lipid levels.


METHODS
The apoE genotypes of 52 early-onset CHD patients (aged 38-55 years), 161 aged CHD patients and 180 controls were determined by PCR-RFLP. Plasma lipid levels were measured by using routine methods.


RESULTS
Five genotypes of apoE, E3/3, E4/4, E3/2, E4/3 and E4/2 were detected in this study. Statistically differences in apoE4/3 and epsilon4 frequencies between early-onset and aged CHD patients and controls were seen (P<0.05). The frequency of epsilon4 in the early-onset CHD patients was higher than that in the aged CHD patients. epsilon4 and epsilon2 alleles also differently affected the plasma total cholesterol and low density lipoprotein cholesterol levels.


CONCLUSIONS
These results suggest that apoE gene polymorphism is in association with the occurrence and development of early-onset CHD and it affects the plasma lipid levels.
Peng
S
S
Zhuhai People's Hospital, The Third Affiliated Hospital of Jinan University, Zhuhai, Guangdong, 519000 P.R. China. peng_shu@163.net
Peng
J
J
Gong
W
W
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E; D008078:Cholesterol, LDL; D008055:Lipids