title: Decreased susceptibility to pentylenetetrazol-induced seizures after low-frequency transcranial magnetic stimulation in rats.
abstract: We studied the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on seizure susceptibility in rats. rTMS of 1000 pulses at 0.5 Hz led to a prolonged latency for seizure development after an intraperitoneal injection of pentylenetetrazol. The rTMS effectively prevented the development of status epilepticus of pentylenetetrazol-induced convulsions. These findings indicate that low-frequency rTMS affects the neural excitability, in the direction of anticonvulsive, and therefore, suggest the possibility of therapeutic use of rTMS in epilepsy.
authors.affiliation: Department of Neurology, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. akamatn@med.uoeh-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Akamatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Fueta
authors.forename: Y
authors.initials: Y
authors.lastname: Endo
authors.forename: K
authors.initials: K
authors.lastname: Matsunaga
authors.forename: T
authors.initials: T
authors.lastname: Uozumi
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
mesh_terms: D000818:Animals; D003292:Convulsants / Q000494:pharmacology*; D004351:Drug Resistance; D004558:Electric Stimulation; D004569:Electroencephalography; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation
chemical_list: D003292:Convulsants; D010433:Pentylenetetrazole