title: Unresectable primary tumor of head and neck: does neck dissection combined with chemoradiotherapy improve survival?
abstract: A study regarding patients with primary and previously untreated advanced histologically proven squamous cell carcinoma of the head and neck was performed to compare two treatment modalities: neck dissection followed by chemoradiotherapy (Group I) versus chemoradiotherapy alone (Group II). Fifty-four patients were randomly chosen to receive Group I or II treatment. Our results demonstrate that Group I treatment has a higher and statistically significant disease-specific survival rate. We suggest that an association of neck dissection plus chemoradiotherapy can be useful in the event of unresectable advanced carcinomas.
authors.affiliation: E.N.T. Clinic, University of Ferrara, Italy. crc@unife.it
authors.forename: F
authors.initials: F
authors.lastname: Carinci
authors.forename: L
authors.initials: L
authors.lastname: Cassano
authors.forename: A
authors.initials: A
authors.lastname: Farina
authors.forename: S
authors.initials: S
authors.lastname: Pelucchi
authors.forename: C
authors.initials: C
authors.lastname: Calearo
authors.forename: V
authors.initials: V
authors.lastname: Modugno
authors.forename: I
authors.initials: I
authors.lastname: Nielsen
authors.forename: P
authors.initials: P
authors.lastname: Api
authors.forename: A
authors.initials: A
authors.lastname: Pastore
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007262:Infusions, Intravenous; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000601:surgery; D009367:Neoplasm Staging; D016016:Proportional Hazards Models
chemical_list: D002945:Cisplatin; D005472:Fluorouracil