title: Time course of cerebral infarction in the middle cerebral arterial territory: deep watershed versus territorial subtypes on diffusion-weighted MR images.
abstract: OBJECTIVE
  To examine possible differences between the evolution of cerebral watershed infarction (WI) and that of territorial thromboembolic infarction (TI) by using diffusion-weighted (DW) and T2-weighted magnetic resonance (MR) images and apparent diffusion coefficient (ADC) maps.
  
  
  METHODS
  Fourteen patients with TI and nine with WI underwent MR imaging from the acute to chronic infarction stages. ADC maps were derived from DW images. Lesion-to-normal tissue signal intensity ratios on ADC maps (rADC), echo-planar T2-weighted images, and DW images were calculated. Lesion volumes at acute or early subacute infarction stages were measured on DW images, and final lesion volumes were estimated on fluid-attenuated inversion-recovery images.
  
  
  RESULTS
  Analysis of variance revealed a significant difference in temporal evolution patterns of rADC between WI and TI (P <.001). rADC pseudonormalization following TI began about 10 days after symptom onset, but that following WI did not occur until about 1 month after symptom onset. The Pearson correlation coefficient between final and initial infarct volumes was 0.9899 for both infarction subtypes, indicating that the initial ischemic injury volume measured at the acute or early subacute stage predicted the final lesion volume fairly well.
  
  
  CONCLUSIONS
  The evolution time of ADC is faster for TI than for WI. This difference, which likely originates from the different pathophysiologic and hemodynamic features of the two infarction types, might account for the relatively large range of ADC values reported for the time course of ischemic strokes.
authors.affiliation: Department of Electrical Engineering, National Taiwan Univ, Taipei, Taiwan, Republic of China.
authors.forename: I J
authors.initials: IJ
authors.lastname: Huang
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: H W
authors.initials: HW
authors.lastname: Chung
authors.forename: D C
authors.initials: DC
authors.lastname: Chang
authors.forename: C C
authors.initials: CC
authors.lastname: Lee
authors.forename: S C
authors.initials: SC
authors.lastname: Chin
authors.forename: M
authors.initials: M
authors.lastname: Liou
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D004058:Diffusion; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism / Q000473:pathology*; D002542:Intracranial Embolism and Thrombosis / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014867:Water
chemical_list: D014867:Water