title: Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis.
abstract: We report a case of gliosarcoma with areas of primitive neuroepithelial differentiation arising in the temporal lobe of a 53-year-old man. The sarcomatous component of this tumor was perivascular in its distribution and showed expression of factor VIII-related antigen, smooth muscle actin and CD34. The primitive neuroepithelial component possessed a small cell morphology and showed expression of neuronal antigens. Strong expression of p53 was demonstrated throughout the tumor with only focal weak expression of epidermal growth factor receptor. The tumor developed widespread extraneural metastases 5 months after surgical resection of the primary tumor. Histological examination of the liver metastases showed them to consist predominantly of the primitive neuroepithelial component. We believe this to be a novel pattern of differentiation in a gliosarcoma which in this case was associated with an aggressive metastatic potential.
authors.affiliation: Academic Unit of Pathology, University of Sheffield Medical School, UK. s.wharton@sheffield.ac.uk
authors.forename: S B
authors.initials: SB
authors.lastname: Wharton
authors.forename: I R
authors.initials: IR
authors.lastname: Whittle
authors.forename: D A
authors.initials: DA
authors.lastname: Collie
authors.forename: H S
authors.initials: HS
authors.lastname: Bell
authors.forename: J W
authors.initials: JW
authors.lastname: Ironside
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary*; D001842:Bone and Bones / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D018450:Disease Progression; D005500:Follow-Up Studies; D018316:Gliosarcoma / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor