title: Regional Brazilian diet-induced low birth weight is correlated with changes in renal hemodynamics and glomerular morphometry in adult age.
abstract: Number of nephrons, renal hemodynamics, and glomerular morphometry were assessed in rats submitted to a multideficient diet which was developed from a basic regional diet consumed in a Brazilian region of sugarcane cultivation. We evaluated three groups of male Wistar rat offspring: (1) from dams fed a standard diet throughout mating, pregnancy and lactation (control group) and (2) from dams fed the multideficient diet during mating and pregnancy (MalN1 group) or (3) throughout mating, pregnancy, and lactation (MalN2 group). At adult age, the animals were anesthetized to measure mean arterial blood pressure and renal hemodynamics. The MalN1 group, as compared with the control group, showed unaltered body and kidney weights, nephron deficiency, a high mean arterial blood pressure, glomerular hypertrophy, and renal vasoconstriction. The MalN2 group showed the same nephron deficiency and mean arterial blood pressure levels as the MalN1 group. These animals exhibited lower body and kidney weights and no glomerular hypertrophy. In conclusion, the alterations induced by intrauterine malnutrition are compatible with the development of chronic renal failure.
authors.affiliation: Department of Physiology and Pharmacology, Biological Science Center, Universidade Federal de Pernambuco, Recife, Brazil. adpaixao@npd.ufpe.br
authors.forename: A D
authors.initials: AD
authors.lastname: Paixão
authors.forename: C R
authors.initials: CR
authors.lastname: Maciel
authors.forename: M B
authors.initials: MB
authors.lastname: Teles
authors.forename: J
authors.initials: J
authors.lastname: Figueiredo-Silva
mesh_terms: D000818:Animals; D001724:Birth Weight; D001794:Blood Pressure; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight; D001938:Brazil; D004032:Diet; D005260:Female; D006439:Hemodynamics; D007668:Kidney / Q000098:blood supply*; D007676:Kidney Failure, Chronic / Q000209:etiology; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D009318:Natriuresis; D009748:Nutrition Disorders / Q000150:complications*; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001798:Blood Proteins