title: AdGVVEGF121.10 (GenVec).
abstract: GenVec, in collaboration with Pfizer (formerly Parke-Davis), is developing AdGVVEGF121.10 (BioBypass), a gene therapy involving the 121-residue isoform of vascular endothelial growth factor (VEGF), licensed from Scios, for the potential treatment of coronary artery disease (CAD) and peripheral vascular disease (PVD) [262000]. By March 2000, phase II trials in CAD had commenced [359531], [359532], [359538]. By August 2000, phase II trials were also underway for PVD [386293]. The initial phase II trial will include approximately 70 patients with severe CAD who are not candidates for bypass surgery and will assess exercise capacity and patient well-being, before and after treatment, as well as safety and drug tolerance [364137]. Scios licensed the gene transfer applications of VEGF121 to GenVec in June 1996 [263381]. In September 1997, GenVec entered into an agreement with Parke-Davis, a subsidiary of Warner-Lambert (now Pfizer), to develop the therapy [262000]. In May 1999, Warner-Lambert signed an agreement with Bioscience for a device for the administration of AdGVVEGF121.10 1325443]. In May 2000, Merrill Lynch predicted a US filing in the first half of 2003 [375962]. In January 2001, AG Edwards predicted the product would generate $70 million in revenues to Pfizer and $12 million in royalties to GenVec in 2005. In February 1999, GenVec was awarded US-05846782, covering vectors for targeting the transfer of therapeutic genes to specific tissues in the human body [316038].
authors.affiliation: Clinic for Bone Marrow Transplantation and Hematology/Oncology, Idar-Oberstein, Germany. nbasara@bmt-center-io.com
authors.forename: N
authors.initials: N
authors.lastname: Basara
mesh_terms: D042501:Angiogenic Proteins; D000818:Animals; D002986:Clinical Trials as Topic; D016228:Endothelial Growth Factors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D015316:Genetic Therapy; D006801:Humans; D008222:Lymphokines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014652:Vascular Diseases / Q000628:therapy*
chemical_list: C437806:AdGVVEGF121.10; D042501:Angiogenic Proteins; D016228:Endothelial Growth Factors; D008222:Lymphokines