Swine model of arterial bifurcation aneurysm.
OBJECTIVE
To create an arterial bifurcation aneurysm model in swine and evaluate it with digital subtraction angiography (DSA).


METHODS
Ten swine were used for constructing the arterial bifurcation aneurysm models. Seven pigs underwent subsequent intraarterial DSA. Both surgical procedure and transarterial angiography were carried out under anesthesia with mechanical ventilation after tracheal intubation.


RESULTS
Bifurcation aneurysms were surgically created in ten animals. After surgical procedure, 2 pigs died from aneurysmal rupture and one died of anesthetic overdose. DSA was performed in all other 7 animals and it demonstrated 6 patent aneurysms and one occluded. Three of the 6 patent bifurcation aneurysms were wide-necked and 3 were narrow-necked.


CONCLUSIONS
Arterial bifurcation aneurysm model can be successfully constructed in swine. It will provide us with an in vivo model to observe and develop therapeutic devices, teach endovascular techniques, and study aneurysmal hemodynamics.
Wang
J
J
Department of Radiology, Section of Interventional Radiology, First Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Rd., Nanjing 210029, China.
Turjman
F
F
Ongolo-Zogo
P
P
Acevedo
J C
JC
Poirier
C
C
D000783:Aneurysm / Q000000981:diagnostic imaging*; D015901:Angiography, Digital Subtraction; D000818:Animals; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D017536:Carotid Artery, Common; D004195:Disease Models, Animal; D013552:Swine