title: [A case of systemic fat embolism in mixed connective tissue disease associated with interstitial pneumonia during steroid treatment].
abstract: A 67-year-old man with a four-year history of mixed connective tissue disease (MCTD) associated with interstitial pneumonia was admitted to our hospital with a complaint of dyspnea and moist cough. Because the interstitial pneumonia was exacerbated, he was given high-dose steroid treatment (pulse therapy and sequential oral treatment of PSL 50 mg/day). After treatment his general condition showed some improvement, but then he suddenly died of acute respiratory failure. Autopsy disclosed fat emboli in the lungs, kidneys, liver and myocardium. The fat embolism may have been a consequence of the steroid treatment. Fat embolism should be taken into account as one of the causes of the acute respiratory failure in collagen vascular disease patients receiving steroid treatment.
authors.affiliation: Department of Respiratory Medicine, Nagaoka Red Cross Hospital, Terashima, Nagaoka 940-2085, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kourakata
authors.forename: Y
authors.initials: Y
authors.lastname: Tanabe
authors.forename: O
authors.initials: O
authors.lastname: Mikami
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: E
authors.initials: E
authors.lastname: Suzuki
authors.forename: F
authors.initials: F
authors.lastname: Gejyo
mesh_terms: D000208:Acute Disease; D000368:Aged; D003645:Death, Sudden / Q000209:etiology*; D004620:Embolism, Fat / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications*; D008297:Male; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D012131:Respiratory Insufficiency / Q000209:etiology
chemical_list: D011239:Prednisolone