title: Elective stenting of unprotected left main coronary artery stenosis: effect of debulking before stenting and intravascular ultrasound guidance.
abstract: OBJECTIVE
  We sought to evaluate: 1) the long-term outcomes of 127 selected patients receiving unprotected left main coronary artery (LMCA) stenting; and 2) the impact of the debulking procedure before stenting and intravascular ultrasound (IVUS) guidance on their clinical outcomes.
  
  
  BACKGROUND
  The long-term safety of stenting of unprotected LMCA stenoses has not been established yet.
  
  
  METHODS
  A total of 127 consecutive patients with unprotected LMCA stenosis and normal left ventricular function were treated by elective stenting. The long-term outcomes were evaluated between two groups: IVUS guidance (n = 77) vs. angiographic guidance (n = 50); and debulking plus stenting (debulking/stenting; n = 40) vs. stenting only (n = 87).
  
  
  RESULTS
  Angiographic restenosis was documented in 19 (19%) of 100 patients. The lumen diameter after stenting was significantly larger in IVUS-guided group (p = 0.003). The angiographic restenosis rate was significantly lower in the debulking/stenting group (8.3% vs. 25%, p = 0.034). The reference artery size was the only independent predictor of angiographic restenosis. During follow-up (25.5 +/- 16.7 months), there were four deaths, but no nonfatal myocardial infarctions occurred. The survival rate was 97.0 +/- 1.7% at two years.
  
  
  CONCLUSIONS
  These data suggest that stenting of unprotected LMCA stenosis might be associated with a favorable long-term outcome in selected patients. Guidance with IVUS may optimize the immediate results, and debulking before stenting seems to be effective in reducing the restenosis rate. However, we need a large-scale, randomized study.
authors.affiliation: Department of Medicine, College of Medicine, University of Ulsan, Cardiac Center, Asan Medical Center, Seoul, South Korea. sjpark@www.amc.seoul.kr
authors.forename: S J
authors.initials: SJ
authors.lastname: Park
authors.forename: M K
authors.initials: MK
authors.lastname: Hong
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.forename: J J
authors.initials: JJ
authors.lastname: Kim
authors.forename: J K
authors.initials: JK
authors.lastname: Song
authors.forename: D H
authors.initials: DH
authors.lastname: Kang
authors.forename: S W
authors.initials: SW
authors.lastname: Park
authors.forename: G S
authors.initials: GS
authors.lastname: Mintz
mesh_terms: D000368:Aged; D017225:Atherectomy, Coronary; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015607:Stents; D018084:Ultrasonography, Interventional