title: Meningeal leishmaniosis induced by Leishmania infantum in naturally infected dogs.
abstract: We report two cases of meningitis caused by Leishmania infantum in naturally infected dogs. In both of these dogs the typical phenotypic features of granulomatous meningitis were observed with important lympho-plasma-cellular infiltrates and the presence of large numbers of parasites inside and outside macrophages. The immunological study of the cerebrospinal fluid of both animals showed that a large number of protein bands were recognized by those fluids and that they were similar to the ones recognized by the sera from the same animals. To our knowledge, this is the first description of meningitis associated to leishmaniosis.
authors.affiliation: Departamento de Microbiología, Hospital San Pedro de Alcántara, Cáceres, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Viñuelas
authors.forename: M
authors.initials: M
authors.lastname: García-Alonso
authors.forename: L
authors.initials: L
authors.lastname: Ferrando
authors.forename: I
authors.initials: I
authors.lastname: Navarrete
authors.forename: I
authors.initials: I
authors.lastname: Molano
authors.forename: C
authors.initials: C
authors.lastname: Mirón
authors.forename: J
authors.initials: J
authors.lastname: Carcelén
authors.forename: C
authors.initials: C
authors.lastname: Alonso
authors.forename: C G
authors.initials: CG
authors.lastname: Nieto
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000134:cerebrospinal fluid; D020808:Central Nervous System Protozoal Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D002555:Cerebrospinal Fluid / Q000276:immunology / Q000469:parasitology; D004283:Dog Diseases / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D018314:Leishmania infantum / Q000276:immunology / Q000302:isolation & purification*; D007898:Leishmaniasis, Visceral / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D008581:Meningitis / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D012698:Serologic Tests / Q000662:veterinary
chemical_list: D000913:Antibodies, Protozoan