title: [Prospective study to compare high-resolution computed tomography and magnetic resonance imaging in the detection of pancreatic neoplasms: use of intravenous and oral MR contrast media].
abstract: OBJECTIVE
  To compare thin-section hydro-CT and MRI in the detection of pancreatic neoplasms. Evaluation of an oral, superparamagnetic contrast agent (OMP) for pancreatic MRI.
  
  
  METHODS
  45 patients with suspected pancreatic neoplasms were examined with consecutive thin-section helical CT (Hydro-CT, 3/6/3, 130 ml Ultravist, Schering) and MRI (1.0 T, breath-holding, T1w-GRE, T1w-GRE fat-sat, T2w-TSE). The MRI protocol included precontrast studies, studies after oral administration of OMP (Abdoscan, Nycomed Amersham) and studies after administration of OMP and Gadodiamide i.v. (Omniscan, Nycomed Amersham). All images were assessed by two independent radiologists in a blinded fashion. Radiologic diagnosis was correlated with histology or clinical follow-up (> or = 3 month).
  
  
  RESULTS
  39 patients could be included in analysis. In 13 cases a pancreatic neoplasm was proven by histology. Thin-section hydro-CT and MRI showed no statistically significant differences for the detection of pancreatic neoplasia. The sensitivity of helical hydro-CT was superior compared to MRI (88.5% vs. 65.44/73.1%/76.9%). The specificity of MRI was superior compared to helical hydro-CT (86.5% vs. 94.2%/90.4%/88.5%).
  
  
  CONCLUSIONS
  Thin-section hydro-CT and MRI show similar results for the detection of pancreatic neoplasms. Compared to thin-section helical CT, MRI still has the drawbacks of much more time consumption and, still, lower spatial resolution. The use of an oral, superparamagnetic contrast agent added no advantage for pancreatic MRI.
authors.affiliation: Abteilung Radiodiagnostik Radiologische Universitätsklinik Heidelberg.
authors.forename: C
authors.initials: C
authors.lastname: Fink
authors.forename: L
authors.initials: L
authors.lastname: Grenacher
authors.forename: H J
authors.initials: HJ
authors.lastname: Hansmann
authors.forename: M
authors.initials: M
authors.lastname: Düx
authors.forename: R
authors.initials: R
authors.lastname: Leipold
authors.forename: E
authors.initials: E
authors.lastname: Spielhaupter
authors.forename: G W
authors.initials: GW
authors.lastname: Kauffmann
authors.forename: G M
authors.initials: GM
authors.lastname: Richter
mesh_terms: D000284:Administration, Oral; D001706:Biopsy; D003287:Contrast Media / Q000008:administration & dosage*; D003627:Data Interpretation, Statistical; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D007501:Iron / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000008:administration & dosage; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; C064925:gadodiamide; D007501:Iron; D019786:Gadolinium DTPA