Identification of two new HLA-B22 variants, HLA-B*5509 and B*5606.
In our recent study using high-resolution HLA-B locus typing by sequence-based typing (SBT) we identified 9 new alleles in a total of 355 unrelated individuals (4). Three of them concerned an allele belonging to the B22 group. One of them, B*5607, showed the unusual presence of a Bw4 sequence motif, as described previously (5). In this report the other two B22 variants are described; one belonging to the B55 specificity and named B*5509; the other one being a B*56 allele and assigned B*5606, which brings the total number of alleles belonging to the B22 group to 18.
Voorter
C E
CE
Tissue Typing Laboratory, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands.
Hepkema
B G
BG
Mulkers
E M
EM
Lems
S P
SP
van den Berg-Loonen
E M
EM
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D015235:HLA-B Antigens; C105903:HLA-B22 antigen