title: Correlation between local glucose transporter densities and local 3-O-methylglucose transport in rat brain.
abstract: The present study addresses the question whether local glucose transport kinetics are correlated with local glucose transporter densities in the brain. In 47 brain structures the local rate constants for 3-O-[(14)C]methylglucose (3-O-MG) transport, K(1) and k(2,) were quantified, and local glucose Glut1 and Glut3 transporter densities were determined by immuno-autoradiographic methods. Statistically significant correlations were found between the rate constants for glucose transport and the transporter densities. The correlations were tighter for Glut1 than for Glut3. Inasmuch as 3-O-MG is transported by the same transporter as glucose, these results indicate that the local densities of glucose transporters determine local glucose transport rates in the brain.
authors.affiliation: Department of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326 D-69120 Heidelberg, Germany. roman.duelli@pio1.uni.heidelberg.de
authors.forename: R
authors.initials: R
authors.lastname: Duelli
authors.forename: M H
authors.initials: MH
authors.lastname: Maurer
authors.forename: R
authors.initials: R
authors.lastname: Staudt
authors.forename: L
authors.initials: L
authors.lastname: Sokoloff
authors.forename: W
authors.initials: W
authors.lastname: Kuschinsky
mesh_terms: D019325:3-O-Methylglucose / Q000493:pharmacokinetics*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000502:physiology; D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3; D008297:Male; D009004:Monosaccharide Transport Proteins / Q000032:analysis / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D051272:Glucose Transporter Type 1; D051274:Glucose Transporter Type 3; D009004:Monosaccharide Transport Proteins; D009419:Nerve Tissue Proteins; C495679:Slc2a1 protein, rat; C495690:Slc2a3 protein, rat; D019325:3-O-Methylglucose