Cannabinoids and pain.
Recent advances have dramatically increased our understanding of cannabinoid pharmacology: the psychoactive constituents of Cannabis sativa have been isolated, synthetic cannabinoids described and an endocannabinoid system identified, together with its component receptors, ligands and their biochemistry. Strong laboratory evidence now underwrites anecdotal claims of cannabinoid analgesia in inflammatory and neuropathic pain. Sites of analgesic action have been identified in brain, spinal cord and the periphery, with the latter two presenting attractive targets for divorcing the analgesic and psychotrophic effects of cannabinoids. Clinical trials are now required, but are hindered by a paucity of cannabinoids of suitable bioavailability and therapeutic ratio.
Rice
A S
AS
Imperial College School of Medicine, Department of Anaesthetics, London, UK. a.rice@ic.ac.uk
D000577:Amides; D000581:Amidohydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D001095:Arachidonic Acids / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D048588:Benzoxazines; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001892:Camphanes / Q000737:chemistry; D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids / Q000737:chemistry / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D002462:Cell Membrane / Q000378:metabolism; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D015195:Drug Design; D004347:Drug Interactions; D063388:Endocannabinoids; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004983:Ethanolamines; D005989:Glycerides / Q000096:biosynthesis / Q000737:chemistry; D006801:Humans; D007278:Injections, Spinal; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry; D009281:Naphthalenes / Q000737:chemistry; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010168:Palmitates / Q000494:pharmacology; D010169:Palmitic Acids / Q000627:therapeutic use*; D010880:Piperidines / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles / Q000737:chemistry; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000819:agonists* / Q000032:analysis / Q000378:metabolism; D000077285:Rimonabant; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism; D000099252:Fatty Acid Amide Hydrolases
D000577:Amides; D000581:Amidohydrolases; D000700:Analgesics; D001095:Arachidonic Acids; D048588:Benzoxazines; D001892:Camphanes; D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids; D063388:Endocannabinoids; D004791:Enzyme Inhibitors; D004983:Ethanolamines; D005989:Glycerides; D009025:Morpholines; D009281:Naphthalenes; D010168:Palmitates; D010169:Palmitic Acids; D010880:Piperidines; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D000077285:Rimonabant; D000099252:Fatty Acid Amide Hydrolases; C104963:AM 374; C110630:SR 144528; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone; C005958:palmidrol; C094503:glyceryl 2-arachidonate; C078814:anandamide; C107594:N-(4-hydroxyphenyl)arachidonylamide