Neurokinin-1 receptor immunoreactivity in hypotension sensitive sympathetic preganglionic neurons.
Substance P activation of neurokinin-1 (NK1) receptors on spinal sympathetic preganglionic neurons (SPN) influences blood pressure. We identified SPN likely to subserve the baroreceptor reflex and established if these neurons showed NK1 receptor-immunoreactivity. Nitroprusside (NP) infusion or inferior vena cava (IVC) constriction activated similar numbers of SPN. Of these, about 40% were NK1 receptor-immunoreactive after NP infusion, but only about 20% were NK1 receptor-immunoreactive after IVC constriction. The distribution of Fos/NK1 receptor SPN suggested that substance P may preferentially target sympathoadrenal SPN.
Burman
K J
KJ
Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University of South Australia, South Australia 5042, Bedford Park, Australia. kathy.burman@flinders.edu.au
McKitrick
D J
DJ
Minson
J B
JB
West
A
A
Arnolda
L F
LF
Llewellyn-Smith
I J
IJ
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001339:Autonomic Fibers, Preganglionic / Q000187:drug effects / Q000378:metabolism*; D007022:Hypotension / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018040:Receptors, Neurokinin-1 / Q000096:biosynthesis / Q000378:metabolism*; D013116:Spinal Cord / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism
D000959:Antihypertensive Agents; D018040:Receptors, Neurokinin-1; D009599:Nitroprusside