title: Torsades de pointes caused by Mibefradil.
abstract: We report a case of symptomatic Torsades de pointes due to QTc prolongation by Mibefradil, which potentially explains unexpected deaths related to this drug. Multiple episodes of Torsades de pointes were documented in a 76-year-old woman with significant QTc prolongation of 0.53 s. After discontinuation of Mibefradil QTc intervals normalized and no further ventricular tachyarrythmias were observed. We conclude that Mibefradil can cause QTc prolongation and life threatening ventricular dysrhythmias.
authors.affiliation: Unfallkrankenhaus Berlin, Department of Internal Medicine, Warener Strasse 7, D-12683 Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Gläser
authors.forename: M
authors.initials: M
authors.lastname: Steinbach
authors.forename: C
authors.initials: C
authors.lastname: Opitz
authors.forename: U
authors.initials: U
authors.lastname: Wruck
authors.forename: F X
authors.initials: FX
authors.lastname: Kleber
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy; D002121:Calcium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008133:Long QT Syndrome / Q000150:complications; D020748:Mibefradil / Q000009:adverse effects* / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000139:chemically induced; D016171:Torsades de Pointes / Q000139:chemically induced*
chemical_list: D002121:Calcium Channel Blockers; D020748:Mibefradil