title: Ocular microtremor: a tool for measuring depth of anaesthesia?
abstract: Ocular microtremor (OMT) is a fine high frequency tremor of the eyes caused by extra-ocular muscle activity stimulated by impulses emanating in the brain stem. Several studies have shown that the frequency of this tremor is reduced in patients whose consciousness is reduced by anaesthesia or head injury. Therefore, OMT may possibly be used to determine depth of anaesthesia. Twenty-two unpre-medicated subjects undergoing surgery with general anaesthesia were studied. OMT activity was measured at admission using the open eye piezoelectric strain gauge technique. Anaesthesia was induced with propofol using a target controlled infusion delivery system (Diprifusor). OMT activity was then recorded at predicted plasma propofol concentrations of 1, 2, 3 and 5 microg ml(-1). The patient's level of consciousness (response to command or stimulation) was assessed after each OMT measurement. OMT activity was reduced progressively at predicted plasma concentrations of propofol of I and 2 microg ml(-1) and then plateaued between 3 and 5 microg ml(-1). There was a significant difference between the last awake OMT recording and the first recording at loss of consciousness (P < 0.001). OMT recording holds promise as a practical indicator of the depth of anaesthesia.
authors.affiliation: Department of Neurosurgery, Frenchay Hospital, Bristol, UK
authors.forename: S
authors.initials: S
authors.lastname: Bojanic
authors.forename: T
authors.initials: T
authors.lastname: Simpson
authors.forename: C
authors.initials: C
authors.lastname: Bolger
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000097:blood / Q000494:pharmacology*; D003243:Consciousness / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005133:Eye Movements / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D009801:Oculomotor Muscles / Q000187:drug effects; D015742:Propofol / Q000097:blood / Q000494:pharmacology*; D014202:Tremor / Q000503:physiopathology
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol