title: Disseminated metastatic intramedullary melanoma in an aged grey horse.
abstract: A 12-year-old grey Warmblood stallion presented with fever of unknown origin, and anaemia. Five days later it had developed ataxia and become recumbent, and was humanely killed. At necropsy, malignant melanomas were identified in the perineal subcutis, spleen, and thoracic vertebral canal (T10-11). Populations of malignant melanoma cells were scattered throughout medullary cavities of the axial and appendicular skeleton, and were identified grossly as irregular areas of black to grey discoloration. To the authors' knowledge, this is the first report of disseminated intramedullary melanoma in a domestic species.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, University of Florida, Box 110880, Gainesville, FL 32611-0880, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Patterson-Kane
authors.forename: L C
authors.initials: LC
authors.lastname: Sanchez
authors.forename: E W
authors.initials: EW
authors.lastname: Uhl
authors.forename: L M
authors.initials: LM
authors.lastname: Edens
mesh_terms: D000818:Animals; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D008297:Male; D008545:Melanoma / Q000556:secondary / Q000662:veterinary*; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*; D013125:Spinal Neoplasms / Q000556:secondary / Q000662:veterinary*