[The role of beta3-adrenergic receptor Trp/Arg mutation in childhood obesity].
OBJECTIVE
To understand with greater clearness the role of beta3- adrenergic receptor Trp/Arg mutation in childhood obesity.


METHODS
One hundred and seventy-seven children, aged 6-12 years, were selected. The genotype was detected by restricted fragment length polymorphism, the children's dietaries were surveyed by a 3-day recalling and recording method. Their height, weight were measured, and the data on their living habits were collected from their parents.


RESULTS
The intake of total amount of food and energy of obese children were higher in children with Trp/Trp genotype, but there was no difference between the obese and non-obese children with Trp/Arg genotype. Among children with the Trp/Arg genotype, obese children were less active and did less exercise, they slept more, but there was no difference among children with Trp/Trp genotype.


CONCLUSIONS
The children with beta3-AR Trp/Arg mutation may become obese because of the low energy metabolism; less active and exercise may increase the risk of obesity.
Mo
B
B
Institute of Pediatrics Medicine of Nanjing Medical University, Nanjing, Jiangsu, 210029 P.R. China. bqmo@njmu.edu.cn
Chen
R
R
Guo
X
X
Li
X
X
Gong
H
H
Pan
X
X
D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009154:Mutation; D009765:Obesity / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*
D022702:Receptors, Adrenergic, beta-3