title: Predictive value of the tumor oxygenation by means of pO2 histography in patients with advanced head and neck cancer.
abstract: OBJECTIVE
  The purpose of this analysis was to evaluate the potential of the tumor oxygenation by means of Eppendorf pO2 histography as a predictive test to select patients for treatment alternatives.
  
  
  METHODS
  Pretreatment tumor pO2 histographies of locoregional lymph node metastases were assessed in 194 patients with squamous cell carcinoma of the head and neck. Included in the analysis were 134 patients who received a primary radio- or radiochemotherapy with a radiation dose of > or = 60 Gy, and who had no distant metastasis at beginning of the therapy.
  
  
  RESULTS
  The Cox regression analysis revealed the fraction of pO2 values < or = 2.5 mm Hg (p = 0.004), age (p = 0.04) and radiotherapy/radiochemotherapy (p = 0.03) as significant independent prognostic factors for the survival. The positive and negative predictive values were calculated using different cut-off values of the fraction of pO2 values < or = 2.5 mm Hg and the survival status at 1 or 2 years after beginning of the therapy as endpoint. The highest positive and negative predictive values of all cut-off values were 0.50 and 0.41 at 1 year, and 0.81 and 0.26 at 2 years.
  
  
  CONCLUSIONS
  Our data confirm the influence of the tumor oxygenation on the prognosis of patients with squamous cell carcinoma of the head and neck after radiotherapy. However, the calculated positive and negative predictive values suggest that the pO2 histography alone is not sufficient to be used as a predictive test to successfully select patients for treatment alternatives.
authors.affiliation: Department of Radiooncology, University of Heidelberg, Germany. rudat@uke.uni-hamburg.de
authors.forename: V
authors.initials: V
authors.lastname: Rudat
authors.forename: P
authors.initials: P
authors.lastname: Stadler
authors.forename: A
authors.initials: A
authors.lastname: Becker
authors.forename: B
authors.initials: B
authors.lastname: Vanselow
authors.forename: A
authors.initials: A
authors.lastname: Dietz
authors.forename: M
authors.initials: M
authors.lastname: Wannenmacher
authors.forename: M
authors.initials: M
authors.lastname: Molls
authors.forename: J
authors.initials: J
authors.lastname: Dunst
authors.forename: H J
authors.initials: HJ
authors.lastname: Feldmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000532:radiotherapy*; D015687:Cell Hypoxia; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000532:radiotherapy*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis / Q000378:metabolism*; D011048:Polarography; D011237:Predictive Value of Tests; D011379:Prognosis; D011879:Radiotherapy Dosage; D012044:Regression Analysis; D012680:Sensitivity and Specificity
chemical_list: D006454:Hemoglobins; D010100:Oxygen