Cracking the transcriptional code for cell specification in the neural tube.
The bHLH repressor Olig2 participates in the transcriptional code governing cell fate specification in the ventral spinal cord. By temporally selective interactions with other transcription factors, Olig2 first directs motor neuron fate and later switches to promoting oligodendrocyte production.
Marquardt
T
T
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Pfaff
S L
SL
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002453:Cell Cycle; D002454:Cell Differentiation; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology*; D018257:Helix-Loop-Helix Motifs; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009457:Neuroglia / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors