A cytotoxic diarylheptanoid from Viscum cruciatum.
A diarylheptanoid, 1,7-di-(3',4'-dihydroxyphenyl)-4-hepten-3-one, hirsutanone, has been isolated from the methanolic extract of the aerial parts of Viscum cruciatum (Viscaceae) and characterized by spectroscopic methods and chemical transformations. This compound showed cytotoxic activity against melanoma (UACC-62), renal (TK-10) and breast (MCF-7) cancer cell lines.
Martín-Cordero
C
C
Laboratorio de Farmacognosia, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain. cordero@fafar.us.es
López-Lázaro
M
M
Agudo
M A
MA
Navarro
E
E
Trujillo
J
J
Ayuso
M J
MJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D036381:Diarylheptanoids; D004354:Drug Screening Assays, Antitumor; D006536:Heptanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured; D028181:Viscum / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; D006536:Heptanes; C442173:hirsutanone