title: Plasma bioavailable interleukin-6 is elevated in human immunodeficiency virus-infected patients who experience herpesvirus-associated immune restoration disease after start of highly active antiretroviral therapy.
abstract: This study compared plasma bioavailable interleukin (IL)-6 levels in 3 groups: human immunodeficiency virus (HIV)-infected patients who had a human herpesvirus (HHV)-associated immune restoration disease (IRD) during highly active antiretroviral therapy (HAART); patients who experienced an IRD initiated by Mycobacterium avium complex, hepatitis C virus, or human papillomavirus; and control patients who had uneventful immune reconstitution. Total IL-6, soluble IL-6 receptor (sIL-6R), and soluble gp130 were measured by ELISA, and levels of free IL-6 and sIL-6/IL-6R complex were modeled mathematically. Persons who had an HHV-associated IRD had increased plasma bioavailable IL-6 before HAART, compared with patients who experienced a non-HHV-associated IRD and with control patients, and their plasma bioavailable IL-6 increased progressively over 3-4 years of treatment. Increased IL-6 production may be a feature of HAART-induced restoration of immune responses to HHV infections and may have long-term immunopathologic consequences.
authors.affiliation: Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Western Australia. shelleys@dci.uwa.edu.au
authors.forename: S F
authors.initials: SF
authors.lastname: Stone
authors.forename: P
authors.initials: P
authors.lastname: Price
authors.forename: J
authors.initials: J
authors.lastname: Brochier
authors.forename: M A
authors.initials: MA
authors.lastname: French
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D001682:Biological Availability; D019992:Databases as Topic; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006526:Hepatitis C / Q000150:complications; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications; D019947:Receptors, Interleukin-6 / Q000097:blood; D012189:Retrospective Studies; D014412:Tumor Virus Infections / Q000150:complications
chemical_list: D015850:Interleukin-6; D019947:Receptors, Interleukin-6