Is autologous bone marrow transplant (ABMT) and high-dose chemotherapy an approach that can rescue some children with advanced cancer disease?
The object was to determine the role ABMT in children with advanced cancer Those included had failed to respond to conventional treatment with 4 different ablative chemotherapy regimens. Bone marrow stem cells were identified with CD34. Cellular viability was determined after the bone marrow extraction and before the infusion. Fifteen patients were included, whose ages ranged from 1 to 13 years old with a median of 7. Six had acute leukemia, 6 with primitive neuroectodermic tumors, and 3 with other tumors. The median disease-free survival for the whole group was of 2 months, range of 1 to 29 months and SD of 10.1. A total of 6 children are alive (40%) and without evidence of tumor activity from 1 to 29 months. The disease-free survival rate for these group was of 19.1 months, with an SD of 7.9 months.
Rivera-Luna
R
R
Division of Hematology/Oncology, Instituto Nacional de Pediatría, México, DF. riveraluna@infosel.net.mx
Olaya-Vargas
A
A
Meza-Coria
C
C
Cárdenas-Cardos
R
R
Leal-Leal
C
C
Amador-Zarco
J
J
D000293:Adolescent; D018952:Antigens, CD34; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation / Q000401:mortality* / Q000592:standards; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000379:methods / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000401:mortality / Q000628:therapy*; D016879:Salvage Therapy / Q000379:methods / Q000401:mortality; D015996:Survival Rate; D014182:Transplantation, Autologous
D018952:Antigens, CD34