[Serotonin uptake inhibitors provide rapid relief from premenstrual dysphoria. New findings shed light on how serotonin modulates sex hormone-related behavior].
Premenstrual dysphoria (PMD) is a severe form of premenstrual syndrome, afflicting 5-10% of all women. The cardinal symptom--surfacing between ovulation and menstruation, and disappearing within a few days after the onset of the bleeding--is irritability. Serotonin reuptake inhibitors (SRIs), but not non-serotonergic antidepressants, reduce the symptoms of PMD very effectively. Since the, onset of action of SRIs is rapid when used for PMD, medication may be restricted to the luteal phase. The finding that SRIs are effective for PMD lends support for the hypothesis that a major role for brain serotonin is to modulate sex steroid-driven behavior.
Eriksson
E
E
Avdelningen för farmakologi, institutionen för fysiologi och farmakologi, Göteborgs Universitet.
Andersch
B
B
Ho
H P
HP
Landén
M
M
Sundblad
C
C
D000328:Adult; D001519:Behavior / Q000187:drug effects / Q000502:physiology; D015283:Citalopram / Q000008:administration & dosage; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood / Q000502:physiology; D006801:Humans; D011293:Premenstrual Syndrome / Q000188:drug therapy* / Q000523:psychology; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*; D009435:Synaptic Transmission / Q000187:drug effects
D015283:Citalopram; D012739:Gonadal Steroid Hormones; D011985:Receptors, Serotonin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors