title: [Frequency of duodenal adenomas in patients with familial adenomatous polyposis].
abstract: OBJECTIVE
  To estimate the prevalence of polyps in the stomach and duodenum in patients with familial adenomatous polyposis (FAP), and to examine the relationship between age and severity of duodenal adenomatosis.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  Using the FAP-registry of the Netherlands Foundation for the Detection of Hereditary Tumours, data were obtained from patients who had undergone a gastroduodenoscopy before 1 July 1999. The endoscopic and histological findings were used to classify the duodenal adenomas according to the Spigelman classification.
  
  
  RESULTS
  224 patients had undergone at least one gastroduodenoscopy: 117 men and 107 women with a mean age at the time of the first endoscopy of 37 years (range: 13-78). Fundic gland polyposis was detected in 79 patients (35%), stomach adenomas in 6 patients (3%) and duodenal adenomas in 92 patients (41%). A total of 21 patients (9%) had severe duodenal adenomatosis (Spigelman III or IV). Duodenal adenomatosis was often more severe if the patient was older. Ten patients were known to have duodenal cancer; the mean age at diagnosis was 50.3 years (range: 39-67).
  
  
  CONCLUSIONS
  Nearly 10% of the patients with FAP had developed severe duodenal adenomatosis. The severity of duodenal adenomatosis was related to the patient's age.
authors.affiliation: Universitair Medisch Centrum, afd. Heelkunde, Utrecht.
authors.forename: S
authors.initials: S
authors.lastname: van Ruth
authors.forename: W H
authors.initials: WH
authors.lastname: de Vos tot Nederveen Cappel
authors.forename: C J
authors.initials: CJ
authors.lastname: van Laarhoven
authors.forename: H F
authors.initials: HF
authors.lastname: Vasen
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology*; D011125:Adenomatous Polyposis Coli / Q000150:complications*; D000328:Adult; D000367:Age Factors; D000368:Aged; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000556:secondary; D004384:Duodenoscopy; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012720:Severity of Illness Index