title: [Immunopathological responses in women with chronic inflammatory diseases of the uterus and appendages and their therapeutic correction].
abstract: A total of 145 women with chronic inflammatory diseases of uterus and appendages (IDUA) were examined. Bacterioscopy of smears and culture of vaginal, cervical canal and uterine cavity contents were performed in all patients. Direct immunofluorescence and PCR were used for detection of chlamydiae in scrapes and smears and in biopsy specimens taken from endometrium. The number of T lymphocytes and their subpopulations, B lymphocytes as well as the level of plasmatic cells synthesizing IgA, IgM and IgG and secretory IgA (sIgA), immune complexes and C3 component of the complement were determined in biopsy specimens of the endometrium. Pathomorphological examination revealed structural changes characteristic of the immunocomplex disease (secondary deficiency of sIgA, pronounced suppression of IgA production by plasmocytes along with an essential increase in the number of IgG synthesizing cells and immune complexes fixed to the venule endothelium) were detected. Lectin-histochemical study revealed considerable changes in secretory activity of endometrial epitheliocytes manifested by severe suppression of bactericidal activity of the uterine mucus. The detected disturbances of local protective reactions in the endometrium of women IDUA gave grounds for including immunomodulators into the traditional treatment scheme. The latter made it possible to increase essentially the therapeutic effect.
authors.affiliation: State Medical Academy, Chelyabinsk, Russia.
authors.forename: B I
authors.initials: BI
authors.lastname: Medvedev
authors.forename: E A
authors.initials: EA
authors.lastname: Kazachkova
authors.forename: E L
authors.initials: EL
authors.lastname: Kazachkov
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D001431:Bacteriological Techniques; D002908:Chronic Disease; D004716:Endometritis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D000292:Pelvic Inflammatory Disease / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic