Opening of the clamp: an intimate view of an ATP-driven biological machine.
DNA polymerases require tethering to an accessory factor, typically a ring-shaped clamp, to remain bound to DNA during replication. Three recent structural studies provide unique insight into how these clamps are loaded onto DNA by the clamp loader machinery.
Ellison
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Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Stillman
B
B
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D004258:DNA Polymerase III / Q000378:metabolism; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D008958:Models, Molecular; D011487:Protein Conformation
D004268:DNA-Binding Proteins; D000255:Adenosine Triphosphate; D004247:DNA; D004258:DNA Polymerase III; D004259:DNA-Directed DNA Polymerase