Haploidentical transplantation. Importance of histocompatibility testing and chimerism studies in allogeneic bone marrow/stem cell transplantation.
The transplantation of hematopoietic stem cells is sometimes the only treatment option for certain types of malignancies and hematological disorders. The best way to ensure a positive outcome from this type of procedure is to secure an identical human lymphocyte antigen-matched donor or use an autologous graft. This article reviews the indications for transplantation, the recipient and donor selection process, and posttransplant follow-up. The advantages of using haploidentical donors and the typing process also will be discussed.
Rebellato
L M
LM
East Carolina University School of Medicine, Department of Pathology, Brody Building Room 7S-10, Greenville, NC 27858, USA. rebellatol@mail.ecu.edu
Dobbs
L J
LJ
D002678:Chimera / Q000235:genetics; D016172:DNA Fingerprinting; D006086:Graft vs Host Disease / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology
D006649:Histocompatibility Antigens