title: Transgenic mouse models of Alzheimer's disease.
abstract: Recent advances in the understanding of the genetic basis of Alzheimer's disease have enabled the production of transgenic mouse models of the disease. Utilizing both cDNA- and genomic-based approaches, these mouse models for Alzheimer's disease have already provided valuable insights into the pathogenesis of the disease and potential therapeutic interventions.
authors.affiliation: Dept of Genetics, Case Western Reserve University, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106-4955, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Hock
authors.forename: B T
authors.initials: BT
authors.lastname: Lamb
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics* / Q000628:therapy; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D018076:DNA, Complementary / Q000235:genetics; D004195:Disease Models, Animal; D023281:Genomics; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation
chemical_list: D016564:Amyloid beta-Protein Precursor; D018076:DNA, Complementary