title: [Genetic study of psoriasis in the Kharkov population].
abstract: By means of genetic analysis of 400 individuals suffering from psoriasis the mendelian inheritance model have been rejected: the segregation frequencies are SFNxN = 0.083 and SFNxA = 0.1474. The heritability of psoriasis in the polygenic model is about 100%. The main gene model with incomplete penetration have been proposed (p = 0.044, [symbol: see text]1 = 6.1%, [symbol: see text]2 = 82.2%). 0.189% residents of Kharkov population are homozygotes and 8.32% heterozygotes on psoriatic gene, 0.155% residents are suffering from psoriasis heterozygotes and 0.508% heterozygotes. Among individuals suffering from psoriasis 23% are homozygotes and 77% heterozygotes.
authors.forename: L A
authors.initials: LA
authors.lastname: Atramentova
authors.forename: P P
authors.initials: PP
authors.lastname: Ryzhko
authors.forename: A M
authors.initials: AM
authors.lastname: Fedota
mesh_terms: D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008957:Models, Genetic; D020412:Multifactorial Inheritance; D010375:Pedigree; D019683:Penetrance; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D014455:Ukraine / Q000453:epidemiology