The penetration of cefoperazone and sulbactam into the lumbar intervertebral discs.
Six patients received 1 g and six other patients received 2 g of cefoperazone and sulbactam 15 minutes before lumbar disc surgery. Liquid chromatographic analysis of disc tissue revealed that only patients receiving the 2-g dose had mean tissue levels above the minimum inhibitory concentration for Staphylococcus aureus and epidermidis.
Köroğlu
A
A
Department of Neurosurgery, Faculty of Medicine, Selçuk University, Konya, Turkey.
Acar
O
O
Ustün
M E
ME
Tiraş
B
B
Eser
O
O
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002438:Cefoperazone / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D004359:Drug Therapy, Combination; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism*; D008159:Lumbar Vertebrae / Q000378:metabolism; D013407:Sulbactam / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002438:Cefoperazone; D013407:Sulbactam