[Thyroid hormones and melatonin as means of antioxidant therapy].
The possibility of involvement of thyroid hormones and melatonin in cell protection from damage by active oxygen forms (hydroxyperoxide, superoxide radical, and hypochlorite) was investigated. The intensity of inhibition of luminol-dependent chemiluminescence induced by neutrophils and active oxygen forms in the presence of hormones was evaluated. Antioxidant activities of the enzymes were compared with that of glutathione. Probable mechanisms of antioxidant effect of the studied hormones are discussed.
Dizhe
G P
GP
Diatlov
R V
RV
Dizhe
A A
AA
Krasovskaia
I E
IE
Lyzlova
L V
LV
D000975:Antioxidants; D006801:Humans; D008163:Luminescent Measurements; D008550:Melatonin / Q000502:physiology*; D018375:Neutrophil Activation; D009504:Neutrophils / Q000502:physiology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D013963:Thyroid Hormones / Q000502:physiology*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D013963:Thyroid Hormones; D008550:Melatonin