[The significance of cathepsins B and D and their inhibitors in cancer disease].
Cathepsins play an important role in the pathogenesis of the great number of cancer diseases i.e. in breast, head and neck, liver, pancreas, colon and skin cancer. Estimation of cathepsins activity referring to different kinds of cancer diseases has a significance both in diagnostics and in monitoring of their running. An essential role in cancer disease development is also reported for cathepsins B and D inhibitors. Using drugs that are able to inhibit the harmful activity of cathepsins, would give a chance to supplement an anti-cancer therapy with the new agents. In future, it could increase the efficiency of cancer treatment in a significant way.
Drewa
T
T
Katedra i Zakład Biologii AM w Bydgoszczy.
Olszewska
D
D
Makarewicz
R
R
Drewa
J
J
Wozniak
A
A
Kowalke
K
K
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*
D000970:Antineoplastic Agents; D002403:Cathepsins