title: Screening for mutations of the androgen receptor gene in patients with isolated cryptorchidism.
abstract: OBJECTIVE
  To evaluate the occurrence of mutations of androgen receptor (AR) gene in patients with isolated cryptorchidism.
  
  
  METHODS
  Controlled clinical study.
  
  
  METHODS
  Yamagata University Hospital, Yamagata and Tokyo Electric Power Company Hospital, Tokyo, Japan.
  
  
  METHODS
  Patients with isolated cryptorchidism (n = 48) and a control group of men with normal phenotype (n = 20).
  
  
  METHODS
  Blood (lymphocyte DNA).
  
  
  METHODS
  Screening of the AR gene in exons 1-8 using single-strand conformational polymorphism analysis.
  
  
  RESULTS
  No abnormal band patterns were detected in patients with cryptorchidism or in control subjects within the eight exons of the AR gene.
  
  
  CONCLUSIONS
  AR gene alterations appear to be an unlikely cause of isolated cryptorchidism.
authors.affiliation: Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: I
authors.initials: I
authors.lastname: Sasagawa
authors.forename: J
authors.initials: J
authors.lastname: Ashida
authors.forename: T
authors.initials: T
authors.lastname: Nakada
authors.forename: K
authors.initials: K
authors.lastname: Muroya
authors.forename: T
authors.initials: T
authors.lastname: Ogata
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D008297:Male; D009154:Mutation; D018807:Polymorphism, Single-Stranded Conformational; D011944:Receptors, Androgen / Q000235:genetics*; D012016:Reference Values
chemical_list: D011944:Receptors, Androgen