Synthesis and biological activity of 4',8-dihydroxyisoflavon-7-yl D-hexopyranosides.
Four 4',8-dihydroxyisoflavon-7-yl hexopyranoside derivatives having an aglycon part of A-76202 were synthesized, and their biological activities were evaluated toward rat liver alpha-glucosidase. However, the activities were disappointing.
Watanabe
Y
Y
Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Hiromachi 1-2-58, Shinagawa-ku, Tokyo 140-8710, Japan.
Shiozaki
M
M
Kamegai
R
R
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006001:Glycoconjugates / Q000138:chemical synthesis / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D007529:Isoflavones / Q000138:chemical synthesis* / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D009005:Monosaccharides / Q000138:chemical synthesis*; D051381:Rats; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D006001:Glycoconjugates; D065089:Glycoside Hydrolase Inhibitors; D007529:Isoflavones; D009005:Monosaccharides