title: Productive infection of primary macrophages with human herpesvirus 7.
abstract: Here we demonstrate replication of human herpesvirus 7 (HHV-7), a T-lymphotropic virus, in macrophages. Productive replication was lost after 2 weeks, but HHV-7 DNA was detected up to 1 month after infection. Thus, macrophages become infected by HHV-7 and might play an important role as a viral reservoir, as has been demonstrated for human immunodeficiency virus type 1.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: de Bolle
authors.forename: S
authors.initials: S
authors.lastname: Aquaro
authors.forename: A
authors.initials: A
authors.lastname: van Lommel
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: D
authors.initials: D
authors.lastname: Schols
mesh_terms: D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis; D016199:Herpesvirus 7, Human / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000648:ultrastructure / Q000821:virology*; D008854:Microscopy, Electron; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014779:Virus Replication
chemical_list: D004279:DNA, Viral