Preventive strategies for reducing coronary heart disease-related morbidity and mortality in patients with multiple risk factors.
Based on epidemiologic and clinical evidence, the National Cholesterol Education Program Adult Treatment Panel has identified low-density lipoprotein cholesterol as the primary target for lipid intervention to promote the reduction of high cholesterol through increased awareness and aggressive management of cardiovascular risk factors. These guidelines provide the basis for management of multiple risk factors and applied intervention using diet, exercise, and drug therapy to lower cholesterol levels. Data from primary- and secondary-prevention trials strongly support the rationale for aggressive therapy with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) to significantly reduce morbidity and mortality from coronary heart disease.
Brown
W V
WV
Division of Atherosclerosis and Lipid Metabolism, Emory University School of Medicine, Atlanta, Ga., USA. w.virgil.brown@med.va.gov
D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D009017:Morbidity; D012307:Risk Factors
D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors