The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis.
A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly.
Furley
A J
AJ
Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK. a.j.furley@sheffield.ac.uk
D000818:Animals; D001923:Brain Chemistry / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D018390:Gene Targeting / Q000379:methods; D006801:Humans; D016296:Mutagenesis / Q000235:genetics*; D013569:Synapses / Q000235:genetics*