Statin therapy and stroke prevention.
Hypercholesterolemia has not traditionally been considered an important risk factor in the pathogenesis of stroke. However, recent studies show that statin therapy significantly reduces ischemic stroke for patients with established coronary artery disease. Statin therapy may reduce stroke through amelioration of precerebral atherosclerosis in the carotid artery and the aorta. Anti-atherosclerotic, anti-inflammatory, and antithrombotic actions of statins occur within the blood and in plaque. Statins may also protect against cerebral ischemia through beneficial modulation of the brain endothelial nitric oxide system. Ongoing studies are exploring the role of statin therapy in the primary prevention of stroke and in the prevention of cognitive decline and multi-infarct cerebrovascular disease.
Vaughan
C J
CJ
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA. cjv2001@med.cornell.edu
Delanty
N
N
Basson
C T
CT
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000069059:Atorvastatin; D002545:Brain Ischemia / Q000150:complications; D004660:Encephalitis / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006538:Heptanoic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008148:Lovastatin / Q000494:pharmacology / Q000627:therapeutic use*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011758:Pyrroles / Q000494:pharmacology / Q000627:therapeutic use*; D020521:Stroke / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
D000893:Anti-Inflammatory Agents; D000924:Anticholesteremic Agents; D005343:Fibrinolytic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D008148:Lovastatin; D000069059:Atorvastatin; D019001:Nitric Oxide Synthase