title: Pneumococcal conjugate vaccine serotypes of Streptococcus pneumoniae isolates and the antimicrobial susceptibility of such isolates in children with otitis media.
abstract: The ability of the recently licensed 7-valent pneumococcal conjugate vaccine to cover isolates that cause otitis media, especially drug-resistant ones, was assessed using 500 recently obtained US isolates. Of these isolates, 418 (84%) belonged to vaccine-related serogroups, whereas 82 (16%) belonged to non-vaccine-related serogroups. Serotype 3 accounted for 48 (59%) of the non-vaccine-related serogroups. In addition, 93% of the isolates from patients < or =3 years of age belonged to serotypes that were included in or related to the heptavalent vaccine, compared with 49% of the isolates from older patients (P=.001). Most of the isolates (98%-100%) that were resistant to the antimicrobial agents tested were covered by the heptavalent vaccine, including 95.1% of the isolates from patients <2 years of age. The 7-valent pneumococcal conjugate vaccine could therefore potentially provide protection against all but 1 (type 3) of the common otitis media-associated pneumococcal serogroups identified in this study as well as against 98% of antibiotic-resistant isolates.
authors.affiliation: Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Joloba
authors.forename: A
authors.initials: A
authors.lastname: Windau
authors.forename: S
authors.initials: S
authors.lastname: Bajaksouzian
authors.forename: P C
authors.initials: PC
authors.lastname: Appelbaum
authors.forename: W P
authors.initials: WP
authors.lastname: Hausdorff
authors.forename: M R
authors.initials: MR
authors.lastname: Jacobs
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000494:pharmacology; D017963:Azithromycin / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D002981:Clindamycin / Q000494:pharmacology; D003430:Cross-Sectional Studies; D024881:Drug Resistance, Bacterial; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D022401:Meningococcal Vaccines / Q000276:immunology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010033:Otitis Media / Q000382:microbiology* / Q000517:prevention & control; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000382:microbiology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects / Q000276:immunology* / Q000302:isolation & purification; D018074:Vaccines, Conjugate / Q000276:immunology*
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D010406:Penicillins; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate; D002981:Clindamycin; D000658:Amoxicillin; D017963:Azithromycin