title: [Immune response following administration of multicomponent vaccine VP-4 in elderly patients].
abstract: The dynamics of immunological characteristics after the administration of polycomponent vaccine B[symbol: see text]-4 to elderly persons, constituting a risk group with respect to acute respiratory diseases and exacerbations of chronic inflammatory diseases of respiratory organs, was studied. The nasal-oral administration of the vaccine induced immunological shifts in the systems of local and systemic immunity. The content of the populations of lymphocytes with markers CD3, CD4, CD16, CD20 was found to have positive dynamics. Considerable shifts in the system of local immunity were registered: the content of sIgA and IgA in the saliva greatly increased; in addition, an increase in the titers of antibodies to Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli was observed in persons with initially low titers.
authors.affiliation: Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
authors.forename: N B
authors.initials: NB
authors.lastname: Egorova
authors.forename: B F
authors.initials: BF
authors.lastname: Semenov
authors.forename: E A
authors.initials: EA
authors.lastname: Kurbatova
authors.forename: I B
authors.initials: IB
authors.lastname: Semenova
authors.forename: L A
authors.initials: LA
authors.lastname: Kuz'mina
authors.forename: V N
authors.initials: VN
authors.lastname: Efremova
authors.forename: S A
authors.initials: SA
authors.lastname: Skhodova
authors.forename: L I
authors.initials: LI
authors.lastname: Krasnoproshina
authors.forename: A L
authors.initials: AL
authors.lastname: Beliaev
authors.forename: E I
authors.initials: EI
authors.lastname: Burtseva
authors.forename: I M
authors.initials: IM
authors.lastname: Gruber
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018951:Antigens, CD20 / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage; D017252:CD3 Complex / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008875:Middle Aged; D017452:Receptors, IgG / Q000276:immunology; D012140:Respiratory Tract Diseases / Q000276:immunology / Q000517:prevention & control*; D012463:Saliva / Q000737:chemistry; D013601:T-Lymphocytes / Q000276:immunology; D017778:Vaccines, Combined
chemical_list: D018951:Antigens, CD20; D001428:Bacterial Vaccines; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D017452:Receptors, IgG; C088865:VP-4 vaccine; D017778:Vaccines, Combined