Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats.
The ability of the brain serotonergic system to mediate the effects of interleukin-1beta (IL-1beta) was investigated. Intracerebroventricular administration of IL-1beta induced a significant pyrogenic reaction, depression in social behaviour, loss of body weight and reduced food intake in rats. Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1beta-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity.
Zubareva
O E
OE
Institute for Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia.
Krasnova
I N
IN
Abdurasulova
I N
IN
Bluthe
R M
RM
Dantzer
R
R
Klimenko
V M
VM
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D010134:Fenclonine / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000096:biosynthesis* / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology*
D007375:Interleukin-1; D012702:Serotonin Antagonists; D012701:Serotonin; D010134:Fenclonine