Effect of hyaluronic acid on corneal haze in a photorefractive keratectomy experimental model.
OBJECTIVE
To evaluate the ability of topical hyaluronic acid to decrease corneal opacity after excimer laser photorefractive keratectomy (PRK) in hens.


METHODS
Twenty-four white hens underwent bilateral 193-nm excimer laser PRK to correct -9.00 D of myopia. One eye received postoperative treatment with topical 1% hyaluronic acid six times daily for 3 days; the other eye received phosphate buffered saline. Slit-lamp evaluation by a masked observer was performed for 6 months after PRK, and electron microscopy was carried out at the end of the study.


RESULTS
There were no significant differences in postoperative haze between the eyes treated with hyaluronic acid and those treated with phosphate buffered saline.


CONCLUSIONS
Topical administration of hyaluronic acid had no effect on the development of corneal haze following PRK in hens.
Gómez
S
S
Instituto de Oftalmobiología Aplicada (IOBA), Valladolid, Spain. silvier@iies.es
Herreras
J M
JM
Merayo
J
J
García
M
M
Argüeso
P
P
Cuevas
J
J
D000287:Administration, Topical; D000818:Animals; D002645:Chickens; D003315:Cornea / Q000601:surgery* / Q000648:ultrastructure; D003318:Corneal Opacity / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D054018:Lasers, Excimer; D009216:Myopia / Q000473:pathology / Q000601:surgery*; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D014945:Wound Healing / Q000187:drug effects
D006820:Hyaluronic Acid