[Effect of lithium hydroxybutyrate on the circadian dynamics of the urinary excretion of Li(+), Na(+), K(+), and Ca(2+) in rats depending on the circadian phase of the drug administration].
In winter solstice, the urinary excretion of Li+ and Na+ in intact rats has a uniform circadian profile, while K+ and Ca2+ exhibit a 23-h and 24-h rhythm, respectively. The administration of lithium hydroxybutyrate (10 mg/kg, 6 days) at 8 a.m. forms the 24-h Li+ and Na+ excretion rhythm, while not significantly affecting the circadian profiles of K+ and Ca2+. The lithium loading at 8 p.m. made the circadian urinary excretion profiles of Ca2+ and Na+ uniform, while the excretion of Li+ and K+ acquired a 24-h rhythm. Irrespective of the circadian phase, the administration of lithium hydroxybutyrate decreased the average daily concentration of Na+ in the urine, while the average concentration of Ca2+ remains unchanged; the concentration of K+ decreases after lithium hydroxybutyrate injections in the morning. Upon the morning treatment, lithium cations are excreted faster than after the evening injections.
Zamoshchina
T A
TA
Pharmacology Department, Siberian Medical University, Moskovskii trakt 2, Tomsk, 634050 Russia.
Meleshko
M V
MV
Ivanova
E V
EV
D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology*; D002118:Calcium / Q000652:urine; D002413:Cations, Divalent; D002414:Cations, Monovalent; D002940:Circadian Rhythm; D004573:Electrolytes / Q000652:urine*; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008094:Lithium / Q000652:urine; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D014563:Urodynamics
D018692:Antimanic Agents; D002413:Cations, Divalent; D002414:Cations, Monovalent; D004573:Electrolytes; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D008094:Lithium; D012964:Sodium; D011188:Potassium; D002118:Calcium