title: Acute effect of nicotine on non-smokers: I. OAEs and ABRs.
abstract: This paper is the first in a series of three investigating the role of cholinergic mechanisms in the auditory system by assessing the acute effects of nicotine, an acetylcholinomimetic drug, on aggregate responses within the auditory pathway. In a single-blind procedure, auditory responses were obtained from 20 normal-hearing, non-smokers (10 male) under two conditions (nicotine, placebo). After the drug session, plasma tests revealed a subject's nicotine concentration. The effects of nicotine on early, exogenous responses of the auditory system (otoacoustic emissions and auditory brainstem potentials) are described in this first paper. Results indicated that transdermal administration of nicotine to non-smokers does not significantly affect cochlear activity but does acutely affect the neural transmission of acoustic information. Overall, otoacoustic emissions were unaffected by transdermal nicotine while wave I of the auditory brainstem response was significantly increased in latency and decreased in amplitude.
authors.affiliation: Department of Audiology and Speech Pathology, University of Tennessee, Knoxville, 37996, USA. aharkrid@utk.edu
authors.forename: A W
authors.initials: AW
authors.lastname: Harkrider
authors.forename: C A
authors.initials: CA
authors.lastname: Champlin
authors.forename: D
authors.initials: D
authors.lastname: McFadden
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D001306:Auditory Pathways / Q000187:drug effects / Q000502:physiology; D001933:Brain Stem / Q000187:drug effects / Q000502:physiology; D018678:Cholinergic Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D003051:Cochlea / Q000187:drug effects / Q000502:physiology; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D016037:Single-Blind Method
chemical_list: D018678:Cholinergic Agents; D009538:Nicotine