title: New spirostanol steroids and steroidal saponins from roots and rhizomes of Dracaena angustifolia and their antiproliferative activity.
abstract: The MeOH extract of Nam ginseng (roots and rhizomes of Dracaena angustifolia) afforded nine new compounds, including three spirostanol sapogenins, named namogenins A-C (1-3), four spirostanol saponins, named namonins A-D (4-7), a furostanol saponin, named namonin E (8), and a pregnan glycoside, named namonin F (9), along with another eight known steroidal saponins (10-17). Their structures were determined on the basis of spectral analyses and chemical methods. All compounds were tested for their antiproliferative activity against murine colon 26-L5 carcinoma, human HT-1080 fibrosarcoma, and B-16 BL6 melanoma cells. Compounds 4, 5, and 10 showed potent antiproliferative activity against HT-1080 fibrosarcoma cells, having IC(50) values of 0.2, 0.3, and 0.6 microM, respectively, comparable to that of doxorubicin.
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Q L
authors.initials: QL
authors.lastname: Tran
authors.forename: Y
authors.initials: Y
authors.lastname: Tezuka
authors.forename: A H
authors.initials: AH
authors.lastname: Banskota
authors.forename: Q K
authors.initials: QK
authors.lastname: Tran
authors.forename: I
authors.initials: I
authors.lastname: Saiki
authors.forename: S
authors.initials: S
authors.lastname: Kadota
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003110:Colonic Neoplasms; D004317:Doxorubicin / Q000494:pharmacology; D005354:Fibrosarcoma; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D008545:Melanoma; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012502:Sapogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013150:Spirostans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014744:Vietnam
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012502:Sapogenins; D012503:Saponins; D013150:Spirostans; C438067:namogenin A; C438069:namogenin B; C438068:namogenin C; D004317:Doxorubicin