A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA.
Choi
S
S
Department of Chemistry and Biochemistry, Middlebury College, Middlebury, Vermont 05753, USA. choi@middlebury.edu
Delaney
S
S
Orbai
L
L
Padgett
E J
EJ
Hakemian
A S
AS
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D004249:DNA Damage; D003848:Deoxyguanine Nucleotides / Q000737:chemistry; D004563:Electrochemistry; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D006157:Guanosine Monophosphate / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction; D012313:RNA / Q000737:chemistry* / Q000187:drug effects
D000970:Antineoplastic Agents; D003848:Deoxyguanine Nucleotides; D009944:Organoplatinum Compounds; C013933:dichloro-1,2-diaminocyclohexane platinum complex; C024829:8-hydroxyguanine; D006147:Guanine; D012313:RNA; C007257:2'-deoxyguanosine 5'-phosphate; D006157:Guanosine Monophosphate; D004247:DNA