title: Serum CD23 is not altered in gastroallergic anisakiasis, but correlates with the production of specific IgE and the amount of polyclonal stimulation.
abstract: BACKGROUND
  Previous studies have shown elevated serum levels of the cytokines IL-4 and sCD23 in atopic patients and parasitic disease. Gastroallergic anisakiasis is an acute parasitic disease, accompanied by IgE-mediated clinical symptoms and an important increase of specific and total IgE.
  
  
  METHODS
  Sixteen patients with acute urticaria/angioedema due to parasitism by Anisakis simplex after intake of raw or undercooked fish were selected, and serum samples were taken in the emergency room within 24 h (day 0; n=16), after 1 month (n=16), and after 6 months (n=10). Serum samples were studied for specific IgE against A. simplex, total IgE, sCD23, and IL-4.
  
  
  RESULTS
  Mean values for sCD23 did not change in the observation period. Only 4/16 serum samples showed measurable IL-4 levels. Specific IgE and total IgE levels were found to be elevated after 1 month; after 6 months, they fell to nearly basal values. There was a positive correlation between sCD23 and specific IgE at day 0 and follow-up (r=0.55-0.69, P<0.026); a positive correlation between sCD23 and total IgE (r=0.54-0.62, P<0.056). Basal sCD23 could moderately predict the percentual increment of total IgE in the first month (r=0.56, P<0.038).
  
  
  CONCLUSIONS
  Thus, it seems that interindividual variability of sCD23 is an important factor, with higher values predisposing to more production of unrelated IgE, independently of the parasite's action.
authors.affiliation: Sección de Alergia, Hospital Universitario La Princesa, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Daschner
authors.forename: C
authors.initials: C
authors.lastname: Cuéllar
authors.forename: A
authors.initials: A
authors.lastname: Alonso-Gómez
authors.forename: C Y
authors.initials: CY
authors.lastname: Pascual
authors.forename: M
authors.initials: M
authors.lastname: Martín-Esteban
mesh_terms: D000818:Animals; D017129:Anisakiasis / Q000276:immunology*; D017163:Anisakis / Q000276:immunology; D000909:Antibodies, Helminth / Q000096:biosynthesis / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000097:blood*
chemical_list: D000909:Antibodies, Helminth; D017455:Receptors, IgE; D015847:Interleukin-4; D007073:Immunoglobulin E