Simultaneous occurrence of Epstein-Barr virus associated Hodgkin's disease and HHV-8 related multicentric Castleman's disease: a fortuitous event?
Previous serological or molecular studies by means of the polymerase chain reaction have failed to show an association between classic Hodgkin's disease (HD) and human herpesvirus 8 (HHV-8). Using immunohistochemistry, this study re-examines (with anti-LNA1 antibody) the possible association of HHV-8 with HD, particularly in human immunodeficiency virus (HIV) infected patients. HHV-8 was not detected in the Reed Sternberg cells of the cases examined (33 HIV negative and 17 HIV positive), thus confirming the lack of involvement of HHV-8 in HD. Interestingly, a case of HHV-8 positive multicentric Castleman's disease was associated with Epstein-Barr virus positive HD in the same lymph node, which was probably a fortuitous occurrence.
Caussinus
E
E
Laboratoire d'Anatomie Pathologique and CNRS-CIGH, UPR8291, CHU Purpan, Place du Dr Baylac, 31059 Toulouse, France.
Meggetto
F
F
Delsol
G
G
Brousset
P
P
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology / Q000821:virology*; D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D005871:Castleman Disease / Q000150:complications / Q000473:pathology / Q000821:virology*; D002648:Child; D005260:Female; D004854:Herpesvirus 4, Human; D019288:Herpesvirus 8, Human; D006689:Hodgkin Disease / Q000150:complications / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000276:immunology; D016612:Paraffin Embedding; D010750:Phosphoproteins; D021701:Sentinel Lymph Node Biopsy
D000911:Antibodies, Monoclonal; D009687:Nuclear Proteins; D010750:Phosphoproteins; C118485:latent nuclear antigen (LNA)