title: HIV pathogenesis and activation of CD4 cells.
abstract: Selective upregulation of the transcription of nef and tat genes before integration into the human genome allows HIV to activate CD4 cells and increase viral replication.
authors.affiliation: Division of Infectious Diseases, Emory University School of Medicine, Atlanta, USA.
authors.forename: H
authors.initials: H
authors.lastname: Albrecht
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000821:virology; D015754:Genes, nef; D015756:Genes, tat; D006678:HIV / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D015854:Up-Regulation; D014779:Virus Replication; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D007376:Interleukin-2; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine