[Study of renal transplant by deconvoluted renogram with 99m Tc-mercaptoacetyltriglycine (Mag3)].
OBJECTIVE
To evaluate the usefulness of the 99mTc-MAG3 renogram deconvolution and its derived parameters in kidney graft function monitoring.


METHODS
221 renograms were studied: 64 were diagnosed as functioning graft (FG), 37 as functioning graft with elevated serum creatinine (FG2), 59 as acute tubular necrosis (ATN), 30 as acute rejection (AR), 20 as urinary tract obstruction (OBS) and 11 as cyclosporine nephrotoxicity (TNX). The parameters evaluated were: maximal activity of conventional renogram and mean transit time (MTT), time to reach 20% (T20) and 80% (T80) of the height of the RRF and initial uptake (IU) from the deconvoluted renal retention function (RRF).


RESULTS
MTT and T20 were significantly longer and IU significantly lower in non-functioning grafts. However, MTT and T20 became shorter than in FG when graft function is severely impaired.


CONCLUSIONS
IU, MTT and T20 are more useful than maxim activity of renogram in monitoring kidney graft function and in evaluating renal dysfunction severity. IU is a very sensitive and early parameter.
Bajén
M T
MT
Servicios de Medicina Nuclear y Nefrología, Hospital Princeps d'Espanya, CSUB, L'Hospitalet de Llobregat, Barcelona, Spain.
Mora
J
J
Grinyo
J M
JM
Castelao
A
A
Roca
M
M
Puchal
R
R
González
J
J
Martín-Comín
J
J
D000328:Adult; D000465:Algorithms; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects; D004231:Diuresis; D005260:Female; D006084:Graft Rejection / Q000097:blood; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007668:Kidney / Q000000981:diagnostic imaging* / Q000502:physiology; D007674:Kidney Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000000981:diagnostic imaging*; D007683:Kidney Tubular Necrosis, Acute / Q000000981:diagnostic imaging / Q000209:etiology; D008297:Male; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012079:Renal Circulation; D012680:Sensitivity and Specificity; D017263:Technetium Tc 99m Mertiatide; D019737:Transplants; D016055:Urinary Retention / Q000000981:diagnostic imaging
D007166:Immunosuppressive Agents; D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide; D016572:Cyclosporine; D003404:Creatinine