title: Lethal pulmonary hypoplasia after in-utero myelomeningocele repair.
abstract: BACKGROUND
  In-utero surgical repair of fetal myelomeningocele has been performed as a means to improve the postnatal condition of affected infants.
  
  
  METHODS
  A nulliparous woman underwent in-utero surgical repair of a fetal lumbosacral myelomeningocele at 24 weeks' gestation. Her postoperative convalescence was complicated by pulmonary edema, abdominal pain, chronic oligohydramnios, and preterm labor. The infant was delivered by cesarean at 33 weeks' gestation, but expired from respiratory distress caused by pulmonary hypoplasia at 9 hours of age.
  
  
  CONCLUSIONS
  Until the benefits of in-utero repair of fetal myelomeningoceles are determined by well-controlled clinical trials, this technique remains investigational. Physicians and their patients who are considering this procedure must be fully aware of the potential risks that can occur.
authors.affiliation: Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: G C
authors.initials: GC
authors.lastname: Lu
authors.forename: J
authors.initials: J
authors.lastname: Steinhauer
authors.forename: P S
authors.initials: PS
authors.lastname: Ramsey
authors.forename: O
authors.initials: O
authors.lastname: Faye-Petersen
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000013:Congenital Abnormalities / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D005315:Fetal Diseases / Q000601:surgery*; D005333:Fetus / Q000601:surgery; D006801:Humans; D008168:Lung / Q000002:abnormalities* / Q000473:pathology; D008591:Meningomyelocele / Q000601:surgery*; D016104:Oligohydramnios / Q000209:etiology*; D011183:Postoperative Complications; D011247:Pregnancy; D011654:Pulmonary Edema / Q000209:etiology