Pharmacokinetic interactions of nevirapine and methadone and guidelines for use of nevirapine to treat injection drug users.
Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7-10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.
Clarke
S M
SM
Department of Genitourinary Medicine, St. James's Hospital, Dublin, Ireland. Susan.Clarke@bmc.org
Mulcahy
F M
FM
Tjia
J
J
Reynolds
H E
HE
Gibbons
S E
SE
Barry
M G
MG
Back
D J
DJ
D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004336:Drug Antagonism; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008875:Middle Aged; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics; D019829:Nevirapine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017410:Practice Guidelines as Topic; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015819:Substance Abuse, Intravenous / Q000150:complications* / Q000188:drug therapy
D000701:Analgesics, Opioid; D019380:Anti-HIV Agents; D009292:Narcotic Antagonists; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine; D008691:Methadone