title: Paraquat poisoning in a burn patient.
abstract: Paraquat is a bipyridyl compound widely used as a contact herbicide. Since its introduction in 1962, hundreds of deaths have occurred, usually after suicidal or accidental ingestion. Death after dermal absorption of paraquat is uncommon, but has occurred after either contact with undiluted paraquat, disruption of skin integrity, or prolonged exposure. It is the purpose of this case report to describe a patient who had fatal dermal paraquat absorption after a crop-dusting accident in which he sustained 37% TBSA burns. After 9.5 hours of cutaneous exposure, a paraquat level of 0.169 mg/ml was obtained at 20 hours, the standard lethal dose at 16 hours being 0.16 mg/ml. In light of the apparently irreversible pathophysiology of paraquat poisoning with plasma levels as low as 3 mg/L, prevention and early intervention are the best treatments. Our patient may have survived an otherwise routine thermal injury had his wounds been aggressively irrigated in the field.
authors.affiliation: Department of Plastic and Hand Surgery, Regions Hospital (a University of Minnesota-affiliated hospital), Saint Paul 55101, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Gear
authors.forename: D H
authors.initials: DH
authors.lastname: Ahrenholz
authors.forename: L D
authors.initials: LD
authors.lastname: Solem
mesh_terms: D000062:Accidents, Occupational; D000383:Agriculture; D002056:Burns / Q000150:complications*; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010269:Paraquat / Q000493:pharmacokinetics / Q000506:poisoning*; D012869:Skin Absorption
chemical_list: D006540:Herbicides; D010269:Paraquat