Efficacy of topotecan treatment on an experimental model of transient evoked otoacoustic emissions.
OBJECTIVE
The aim of this study was to investigate the effects of topotecan (Hycamtin), a topoisomerase I inhibiting anticancer agent, on Transient Evoked Otoacoustic Emissions (TEOAEs) of the rabbits. We planned to investigate whether this test might provide a method for monitoring early ototoxic influence of drug administration to the cochlea.


METHODS
The study was conveyed in two groups each consisting of five rabbits with a total of ten ears. Rabbits in group I received i.v. topotecan (0.5 mg/kg once daily) for 3 days. Rabbits in group II received i.v. topotecan (0.25 mg/kg once daily) for 3 days. Cochlear function was serially monitored using transient evoked otoacoustic emissions before administration (BA) and on the 4th and 15th days after administration of topotecan. TEOAEs were analysed in terms of mean stimulus, stability and emission amplitude at 1.0-4.0 kHz.


RESULTS
For group I and II, intergroup and intragroup differences were not statistically significant in the mean stimulus, stability and emission amplitudes at 1.0-4.0 kHz.


CONCLUSIONS
We evaluated the potential role of TEOAEs in early identification of cochlear dysfunction induced by topotecan. It was concluded that topotecan did not have ototoxic effects on the cochlea in the early period of administration. TEOAEs may be useful to monitor the cochlear function and to detect the late stage of ototoxicity especially in the presence of potentially toxic factors for the prevention of permanent damage.
Bayar
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ENT Department, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey. nurayb@hotmail.com
Böke
B
B
Apan
A
A
Koç
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MC
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007275:Injections, Intravenous; D008297:Male; D023421:Models, Animal; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D011336:Probability; D011817:Rabbits; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D019772:Topotecan / Q000494:pharmacology* / Q000633:toxicity*
D019772:Topotecan