title: [Generalized and selective feedback inhibition of secretion of pancreatic enzymes].
abstract: Selective inhibition of secretion of proteinases, amylase and lipase by the pancreas, was revealed. The inhibition is directly dependent on the dose of intraluminal enzymes. The latter's increase transforms the selective inhibition into a generalised one. Possible mechanisms of selective and generalised feedback inhibition of the exocrine pancreatic secretion is discussed, the secretion playing an important role in urgent adaptation of the pancreatic enzymes secretion to the duodenal chyme properties.
authors.affiliation: Russian Centre of Functional Surgical Gastroenterology, 350640 Krasnodar, 4 Sedina St., Russia.
authors.forename: G F
authors.initials: GF
authors.lastname: Korot'ko
authors.forename: S E
authors.initials: SE
authors.lastname: Voskanian
mesh_terms: D000818:Animals; D004285:Dogs; D004386:Duodenum; D025461:Feedback, Physiological; D008049:Lipase / Q000378:metabolism* / Q000494:pharmacology; D010179:Pancreas / Q000378:metabolism*; D014357:Trypsin / Q000378:metabolism* / Q000494:pharmacology; D000516:alpha-Amylases / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D008049:Lipase; D000516:alpha-Amylases; D014357:Trypsin