The influence of tumor necrosis factor-alpha and interleukin-10 gene promoter polymorphism on the inflammatory response in experimental human endotoxemia.
In this study, we show that there is no correlation between tumor necrosis factor-alpha gene promoter polymorphism at position -308, interleukin-10 gene promoter polymorphism at position -1082, and the cytokine levels they produce in the human endotoxemia model.
Fijen
J W
JW
Intensive and Respiratory Care Unit, Department of Internal Medicine, Groningen University Hospital, Groningen, The Netherlands. j.w.fijen@int.azg.nl
Tulleken
J E
JE
Hepkema
B G
BG
van der Werf
T S
TS
Ligtenberg
J J
JJ
Zijlstra
J G
JG
D000328:Adult; D019446:Endotoxemia / Q000097:blood / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10