title: Schistosomal myeloradiculopathy due to Schistosoma mansoni: report on 23 cases.
abstract: Schistosoma mansoni infection is likely to be responsible for a significant proportion of cases of myelopathy occurring in areas where schistosomiasis is endemic. The aim of this study is to describe the clinical, laboratory and therapeutic data of 23 patients with schistosomal myeloradiculopathy. The medical records of 23 patients with schistosomal myelopathy admitted to two general hospitals of Belo Horizonte (MG), in Brazil, from 1995 to 1999, were reviewed retrospectively. Seventeen patients were male (74%). The mean age for the whole group was 27 years. Lower limb weakness and associated lumbar and/or lower limb pain were reported by 20 patients (87%), and 16 (70%) were unable to walk. All individuals presented urinary retention and 19 (83%) complained of intestinal dysfunction. The treatment was based on the association of antischistosomal drugs and corticosteroids. Five patients (22%) presented a full response to treatment, 13 (57%) partial response without functional limitations and 4 (17%) partial improvement with limitations or no response. Three out of the 4 patients who stopped steroids before 45 days of treatment developed recurrence of the symptoms and signs of myelopathy. Our cases demonstrate the severe presentation of the disease and the data disclosed here suggest that treatment with steroids should be kept for months after clinical improvement.
authors.affiliation: Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30130-100, Brasil.
authors.forename: V
authors.initials: V
authors.lastname: Nobre
authors.forename: L C
authors.initials: LC
authors.lastname: Silva
authors.forename: J G
authors.initials: JG
authors.lastname: Ribas
authors.forename: A
authors.initials: A
authors.lastname: Rayes
authors.forename: J C
authors.initials: JC
authors.lastname: Serufo
authors.forename: M A
authors.initials: MA
authors.lastname: Lana-Peixoto
authors.forename: R F
authors.initials: RF
authors.lastname: Marinho
authors.forename: J R
authors.initials: JR
authors.lastname: Lambertucci
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020818:Neuroschistosomiasis / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D012189:Retrospective Studies; D012555:Schistosomiasis mansoni / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012556:Schistosomicides / Q000627:therapeutic use; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D012556:Schistosomicides; D013256:Steroids