Mycobacterium ulcerans cytotoxicity in an adipose cell model.
An adipose cell (SW872) model was developed to observe cellular necrosis and apoptosis upon Mycobacterium ulcerans infection and treatment with mycobacterial exudate. Apoptosis was likely due to secreted proteins, while necrosis was likely due to mycolactone. Our data suggest that additional factors in M. ulcerans may be involved in Buruli ulcer pathogenesis.
Dobos
K M
KM
Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, Georgia 30303, USA. dobos.karen@mayo.edu
Small
P L
PL
Deslauriers
M
M
Quinn
F D
FD
King
C H
CH
D017667:Adipocytes / Q000166:cytology / Q000187:drug effects / Q000382:microbiology*; D000273:Adipose Tissue / Q000166:cytology; D017209:Apoptosis; D001426:Bacterial Proteins / Q000378:metabolism*; D001427:Bacterial Toxins / Q000378:metabolism* / Q000494:pharmacology; D002460:Cell Line; D003470:Culture Media / Q000494:pharmacology; D006801:Humans; D018942:Macrolides; D019911:Mycobacterium ulcerans / Q000378:metabolism* / Q000472:pathogenicity; D009336:Necrosis
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D003470:Culture Media; D018942:Macrolides; C117218:mycolactone