Neonatal tumors of the CNS: a report of 9 cases and a review.
Neonatal central nervous system (CNS) tumors are an uncommon and histologically heterogeneous group of neoplasms with different clinical and biological features from those arising in childhood. We report 9 cases in which a diagnosis of CNS tumor was confirmed by biopsy or autopsy during the years 1982-1997 in the Vall d'Hebrón Children's Hospital, Barcelona. Two cases were fetal tumors detected by fetal sonography, 3 patients were symptomatic in the first days after birth and 4 patients presented initial clinical signs in the first weeks or months of life. Eight lesions were supratentorial and 1 was located in the spinal cord. According to histologic types, there were 2 glioneuronal tumors, 1 anaplastic astrocytoma, 1 choroid plexus carcinoma, 1 immature teratoma, 1 craniopharyngioma, 1 hemangioblastoma, 1 astroblastoma and 1 hemangioendothelioma. Extensive review of the literature indicates that our cases of hemangioblastoma, astroblastoma and hemangioendothelioma are exceptional and one more of the very rare and isolated previously published cases.
Ortega-Aznar
A
A
Department of Neuropathology, Vall d'Hebron University Hospital, Barcelona, España. aortega@cs.vhebron.es
Romero-Vidal
F J
FJ
de la Torre
J
J
Castellvi
J
J
Nogues
P
P
D001706:Biopsy; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000473:pathology*; D008297:Male; D013116:Spinal Cord / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000151:congenital* / Q000473:pathology; D015173:Supratentorial Neoplasms / Q000151:congenital* / Q000473:pathology