The oncogenic potential of Candida in the female genital tract.
The possible role of Candida species in carcinogenesis at the uterine cervix was investigated in 226 females attending a colposcopy clinic. Approximately 34% of the 226 subjects harbored Candida species in cervical/vaginal secretions, but there was no association with any particular histologic abnormality. Two independent analytical procedures were used for strain discrimination of the isolates of C. albicans, but again no relationship was found between individual strains and histologic diagnoses. Only three C. glabrata strains were isolated, but they were all in association with cervical intraepithelial neoplasia (CIN) II or III. A total of 18 strains of C. albicans, one C. glabrata and one C. parapsilosis all inhibited the formation of the nitrosamine nitrosodimethylamine (NDMA) from precursors. Furthermore, C. albicans strains did not convert NDMA to carcinogenic metabolites. The results of this study do not suggest that C. albicans has a role in cervical carcinogenesis.
Lacey
C.J.N.
CJ
Departments of Genitourinary Medicine and Microbiology, University of Leeds and General Infirmary, Leeds, and Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology, Manchester, UK.
Dutton
S.
S
Smith
R.A.
RA
Walmsley
R.M.
RM
Wilkinson
B.M.
BM
Evans
E.G.V.
EG
Hitchcock
C.A.
CA
Adams
D.J.
DJ