title: A multicentric study with arteether in patients of uncomplicated falciparum malaria.
abstract: Two hundred and sixty seven patients of uncomplicated P. falciparum malaria completed study in a multicentric phase III clinical trial of Arteether. Arteether was given intramuscularly in a dose of 150 mg daily for three consecutive days. Each patient was followed upto 28 days of alpha, beta arteether therapy. The cure rate was 97% with fever clearance time between 1-7 days (24-168 hours) and parasite clearance time between 1-3 days (24-72 hours). Parasite reappearance rate was found to be 3% and reported at only three of the centres. Following the treatment no adverse effect was observed on haematological, biochemical and vital clinical parameters.
authors.affiliation: Central Drug Research Institute, Lucknow, India.
authors.forename: O P
authors.initials: OP
authors.lastname: Asthana
authors.forename: J S
authors.initials: JS
authors.lastname: Srivastava
authors.forename: V P
authors.initials: VP
authors.lastname: Kamboj
authors.forename: N
authors.initials: N
authors.lastname: Valecha
authors.forename: V P
authors.initials: VP
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: T K
authors.initials: TK
authors.lastname: Pande
authors.forename: K A
authors.initials: KA
authors.lastname: Vishwanathan
authors.forename: K M
authors.initials: KM
authors.lastname: Mahapatra
authors.forename: N C
authors.initials: NC
authors.lastname: Nayak
authors.forename: P K
authors.initials: PK
authors.lastname: Mahapatra
authors.forename: J
authors.initials: J
authors.lastname: Mahanta
authors.forename: V K
authors.initials: VK
authors.lastname: Srivastava
authors.lastname: Vasdev
authors.forename: N
authors.initials: N
authors.lastname: Singh
authors.forename: M M
authors.initials: MM
authors.lastname: Shukla
authors.forename: A B
authors.initials: AB
authors.lastname: Balsara
authors.forename: S K
authors.initials: SK
authors.lastname: Mishra
authors.forename: S K
authors.initials: SK
authors.lastname: Satpathy
authors.forename: S
authors.initials: S
authors.lastname: Mohanty
authors.forename: B
authors.initials: B
authors.lastname: Dash
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012717:Sesquiterpenes / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C055141:artemotil