title: Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis.
abstract: BACKGROUND
  Although the use of systemic antibiotics has been studied in patients with generalized aggressive periodontitis (formerly rapidly progressive periodontitis), the use of adjunctive tetracycline fibers in these patients has not been reported. The purpose of the present study was to compare the clinical response of local versus systemic antibiotic treatment as adjuncts to scaling and root planing in patients with GAgP.
  
  
  METHODS
  After initial therapy and full-mouth scaling and root planing (SRP), 30 patients were randomly assigned to 1 of 2 antibiotic treatment groups. Probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were recorded with an automated probe prior to SRP at baseline (BL) and 15, 30, 41, and 54 weeks later. Three months after SRP, the patients were treated with amoxicillin/clavulanic acid (500 mg tid; SRP + AUG group) or with local tetracycline fiber in pockets with PD > or =5 mm (SRP + TCF group).
  
  
  RESULTS
  In both treatment groups, PD decreased significantly from BL to week 54 (6.2+/-1.5 mm to 4.7+/-1.4 mm for SRP + TCF and 6.5+/-1.4 mm to 4.2+/-0.6 mm for SRP + AUG). However, there was no statistically significant difference between the 2 groups in pocket reduction. Similarly, in both treatment groups, there were small but significant gains in CAL from BL to week 54 (12.0+/-1.8 mm to 11.3+/-1.8 mm for SRP + TCF and 12.3+/-1.5 mm to 11.2+/-1.2 mm for SRP + AUG). The difference in CAL gain between the 2 groups was not statistically significant. At the final examination, both groups showed significant PD reduction and CAL gain (P <0.001) compared to BL. The frequency and percentage of bleeding sites decreased significantly in both groups. At week 54, this decrease was significantly greater in the SRP + AUG group (31.67% for SRP + TCF versus 3.85% for SRP + AUG).
  
  
  CONCLUSIONS
  These results indicate that the local delivery of tetracycline by a fiber or the systemic administration of amoxicillin/clavulanic acid given 3 months after scaling and root planing produced similar clinical outcomes over the 9-month observation period.
authors.affiliation: Department of Periodontology and Synoptic Dentistry, University Hospital Charité, Humboldt-University at Berlin, Germany. peter.purucker@charite.de
authors.forename: P
authors.initials: P
authors.lastname: Purucker
authors.forename: H
authors.initials: H
authors.lastname: Mertes
authors.forename: J M
authors.initials: JM
authors.lastname: Goodson
authors.forename: J P
authors.initials: JP
authors.lastname: Bernimoulin
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D010520:Aggressive Periodontitis / Q000188:drug therapy; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D012534:Dental Scaling; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D006801:Humans; D010512:Periodontal Index; D010518:Periodontitis / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D013752:Tetracycline / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination; D013752:Tetracycline