Fcgamma receptors in autoimmune diseases.
Fcgamma-receptors (Fcgamma-R) recognise the Fc portion of IgG and thus form a link between humoral and cellular immunity. These receptors are expressed by a variety of immune cells, and they function in the binding of immune complexes or IgG-opsonised particles, such as microbial pathogens. The are three major types of Fcgamma-R, namely Fcgamma-RI (CD64), Fcgamma-RII (CD32) and Fcgamma-RIII (CD16), and these differ in their ability to bind IgG and complexes. There are many isoforms of these receptors and a number of recently identified polymorphisms in their structure. This review describes the structure and function of these Fcgamma-Rs, and highlights how gene deficiencies and polymorphisms may contribute to the pathology of human diseases.
Fossati
G
G
School of Biological Sciences, Life Sciences Building, University of Liverpool, Liverpool L69 7ZB, UK.
Bucknall
R C
RC
Edwards
S W
SW
D001327:Autoimmune Diseases / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics* / Q000276:immunology*
D017452:Receptors, IgG