title: Epithelioid leiomyosarcoma of the uterus with oncocytic change.
abstract: We report on a rare case of epithelioid leiomyosarcoma of the uterus with oncocytic change and aggressive clinical behavior. The tumor arose in the left lateral wall of the uterus and measured 22 cm in greatest dimension. Histologically, it consisted of solid sheets of round and polygonal cells displaying a homogeneously eosinophilic cytoplasm and pleomorphic nuclei with prominent nucleoli. Six mitotic figures were found per 10 high-power fields in the most mitotically active areas, and focal tumor cell necrosis was present elsewhere. Under electron microscopy, numerous normal-appearing mitochondria and occasional bundles of microfilaments with focal densities were noted in the tumor cell cytoplasm, and poorly-formed external basal lamina and occasional pinocytic vesicles were found on the cell membrane of some tumor cells.
authors.affiliation: Department of Laboratory Medicine, University of Alberta Hospitals, Edmonton, Canada. knguyen@cha.ab.ca
authors.forename: G K
authors.initials: GK
authors.lastname: Nguyen
authors.forename: L
authors.initials: L
authors.lastname: Russell
authors.forename: L
authors.initials: L
authors.lastname: Honoré
authors.forename: R
authors.initials: R
authors.lastname: Vriends
mesh_terms: D008841:Actin Cytoskeleton / Q000648:ultrastructure; D014408:Biomarkers, Tumor / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008854:Microscopy, Electron; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure; D008940:Mitotic Index; D009363:Neoplasm Proteins / Q000032:analysis; D009364:Neoplasm Recurrence, Local; D024862:Oxyphil Cells / Q000737:chemistry / Q000473:pathology*; D012187:Retroperitoneal Space; D014594:Uterine Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins