[Experimental study of pharmacotherapeutic effect of phytoecdisteroids and nerobol in toxic liver damage].
Phytoecdysteroids ecdysteron and turkesteron isolated from Ajuga turkestanica (Rgl.) Brig. decrease the manifestations of uremic intoxication in rats with experimental renal pathology induced by a nephrotoxic mixture (containing uranyl acetate and glycerol). Injected in a dose of 5 mg/kg, the drugs restore glomerular filtration level, favor the disappearance of the albuminuria and normalize urinary sediments. The nephroprotector effect of the phytoecdysteroids studied resembles the action of a steroidal anabolic drug nerobol.
Syrov
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VN
Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, ul. Kh. Abdulaeva 77, Tashkent, 700170 Uzbekistan.
Khushbaktova
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ZA
D000818:Animals; D004231:Diuresis; D004441:Ecdysterone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D005990:Glycerol; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008696:Methandrostenolone / Q000494:pharmacology / Q000627:therapeutic use*; D009942:Organometallic Compounds; D008517:Phytotherapy; D011507:Proteinuria / Q000188:drug therapy / Q000652:urine; D051381:Rats
D009942:Organometallic Compounds; C005460:uranyl acetate; D004441:Ecdysterone; C017787:turkesterone; D008696:Methandrostenolone; D005990:Glycerol