Regional blood flow during periodic acceleration.
OBJECTIVE
To determine whether a motion platform that imparts noninvasive periodic acceleration (pGz) forces to the body causes systemic vasodilation and changes local organ blood flow.


METHODS
Prospective paired blocked design.


METHODS
Medical center research laboratory.


METHODS
Juvenile Yorkshire pigs.


METHODS
Juvenile pigs (12 kg) were anesthetized, paralyzed, and placed on a motion platform that oscillated at a frequency of 4 Hz and a force of approximately 0.4 G.


RESULTS
Regional blood flows, as assessed by colored microspheres, increased during pGz relative to values obtained before pGz. Blood flow (mL.min-1.100 g-1) significantly increased to the epicardium (71%), endocardium (93%), cerebrum (183%), brain stem (177%), renal cortex (53%), ileal mucosa (69%), gastric antral mucosa (72%), and liver (86%). Spleen and skeletal muscle blood flow increased without statistical significance, 38% and 158% with pGz, relative to paired control values. Regional blood flows returned to baseline 10 mins after discontinuation of pGz, except in the myocardial layers, where blood flow remained significantly elevated. There was no difference compared with baseline in heart rate, arterial blood gases, and blood pressure, but serum nitrite concentration was significantly higher (58%) during pGz. In another series of animals, pGz increased pulmonary artery blood flow directly proportional to the magnitude of the applied acceleration force with frequency held constant.


CONCLUSIONS
Periodic sinusoidal inertial forces in the spinal axis increase blood flow to tissues. The increased blood flow is reversible and may be caused by vasodilation secondary to local mediator release. These effects may be desirable in clinical conditions of low tissue oxygen delivery and perfusion.
Adams
J A
JA
Division of Neonatology, Mount Sinai Medical Center, Miami Beach, FL, USA.
Mangino
M J
MJ
Bassuk
J
J
Kurlansky
P
P
Sackner
M A
MA
D000054:Acceleration; D000818:Animals; D001696:Biomechanical Phenomena; D001921:Brain / Q000098:blood supply*; D003326:Coronary Circulation / Q000502:physiology*; D004064:Digestive System / Q000098:blood supply*; D004195:Disease Models, Animal; D005260:Female; D008124:Locomotion; D008168:Lung / Q000098:blood supply*; D008297:Male; D009928:Organ Specificity; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D012121:Respiration, Artificial; D012680:Sensitivity and Specificity; D013552:Swine