title: [Neoadjuvant chemoradiotherapy and peroperative radiotherapy for non-small-cell lung cancer of the apex. A study of 5 cases].
abstract: The management of superior sulcus tumors with Pancoast 's syndrome is not well defined, especially in view of their low frequency. Even if surgery performed by "en bloc" resection of the tumor and the chest wall is recommended, neoadjuvant treatment could have a potential benefit on the resecability and pain control. We report five cases of Pancoast tumors (NSCLC), treated by radiotherapy and chemotherapy before surgery. Four tumors was on stage IIIb. A regimen with radiotherapy (50 Gy) and chemotherapy (cisplatinum + etoposide) was initially performed. Four tumors were resected, with 2 complete pathologic responses and good control on pain. Three patients received radiotherapy during surgery. No toxic reaction was observed. This regimen may be discussed with locally advanced tumors and poor prognosis.
authors.affiliation: Service de Pneumologie, Unité 5F, Centre hospitalier Lyon-Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite Cedex et Unité d'Oncologie Médicale, CHU Roanne, 28, rue de Charlien, 42300 Roanne. lionel.vincent@ch-roane.fr
authors.forename: L
authors.initials: L
authors.lastname: Vincent
authors.forename: B
authors.initials: B
authors.lastname: Guibert
authors.forename: F
authors.initials: F
authors.lastname: Mornex
authors.forename: V
authors.initials: V
authors.lastname: Grangeon
authors.forename: R
authors.initials: R
authors.lastname: Harf
authors.forename: F
authors.initials: F
authors.lastname: Gormand
authors.forename: Y
authors.initials: Y
authors.lastname: Pacheco
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D009367:Neoplasm Staging; D010146:Pain / Q000175:diagnosis / Q000209:etiology; D010178:Pancoast Syndrome / Q000209:etiology; D018579:Patient Selection; D011013:Pneumonectomy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D005047:Etoposide; D002945:Cisplatin