Experimental observation of effects of triclabendazole on Paragonimus westermani infection in dogs.
OBJECTIVE
To observe the therapeutic effects of triclabendazole in the treatment of dogs with Paragonimiasis westermani.


METHODS
Six dogs were experimentally infected, each with 100 metacercariae of Paragonimus westermani intraperitoneally and divided into untreated and treated groups, 3 dogs were treated orally with triclabendazole 100 mg/kg.d-1 for 2 consecutive days on day 170 after infection. Stool egg count was done by Stoll method. All dogs were killed on day 38 after treatment and the number of worm cysts and worms in the lungs were examined by naked eye and microscopically.


RESULTS
Stool eggs became negative from day 7 to day 14 after starting chemotherapy in treated dogs. The numbers of worm cysts in the lungs of untreated dogs were 18, 24 and 24 on necropsy, while those in the treated dogs were 10, 7 and 4, respectively. The numbers of adult worms in the untreated dogs were 38, 51 and 42, while in the treated dogs only 2 small adult worms were found in one dog and no worm was found in the other two dogs. The mean worm reduction rate was 98.5%.


CONCLUSIONS
Triclabendazole is highly effective against Paragonimus westermani in experimentally infected dogs.
Liu
Y
Y
Institute of Infectious and Parasitic Diseases, Chongqing University of Medical Sciences, Chongqing 400016, China.
Gao
J
J
Wang
X
X
Yu
D
D
Su
Q
Q
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D004285:Dogs; D008168:Lung / Q000469:parasitology; D010237:Paragonimiasis / Q000188:drug therapy*; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole