title: Architecture and function of the gastroesophageal barrier in the piglet.
abstract: We describe the anatomy and function of the gastroesophageal barrier in the piglet. Male piglets underwent dissection (N = 6) and gastroesophageal muscle layer histometry (N = 6). Sedated, nonintubated animals (N = 13) underwent four-probe perfusion esophageal manometry and the pressure profiles were related to the muscular thickness in the four quadrants. Hiatal and gastroesophageal anatomy are similar to our own. The muscle is thicker at the point where the clasp (on the right side) and sling fibers (on the left) concentrate. The pressure profiles were axially and radially asymmetric in coincidence with the thickness variations of the corresponding muscle layers. Sphincteric pressure was recorded as a plateau, whereas diaphragmatic crural pressure appeared as phasic oscillations in synchrony with respiration. The sphincter relaxed upon deglutition. In conclusion, the gastroesophageal structure and physiology are so similar in men and piglets that piglets are excellent models for research in this area.
authors.affiliation: Department of Pediatric Surgery, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Y
authors.initials: Y
authors.lastname: Vicente
authors.forename: C
authors.initials: C
authors.lastname: Da Rocha
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: G
authors.initials: G
authors.lastname: Hernandez-Peredo
authors.forename: L
authors.initials: L
authors.lastname: Martinez
authors.forename: B
authors.initials: B
authors.lastname: Pérez-Mies
authors.forename: J A
authors.initials: JA
authors.lastname: Tovar
mesh_terms: D000818:Animals; D003679:Deglutition / Q000502:physiology; D004943:Esophagogastric Junction / Q000033:anatomy & histology* / Q000502:physiology*; D008297:Male; D008365:Manometry; D023421:Models, Animal; D013552:Swine