[Lymphoid structure in the mouse cecum wall during immunosuppression and its correction with liposomal agents].
The influence of liposomal preparation obtained from the Baikal seal fat on lymphoid structures in mouse coecum wall on the background of immunodepressive state induced by asathioprine was studied using microscopic methods and statistic analysis. It was demonstrated that asaphioprine administration caused decline in lymphoid serie cells, outgrowth of adipose tissue, causes destructive changes of lymphoid structures in the coecal wall. After the effect of liposomes on the background on the immune suppression morphological state of lymphoid structures was approximated to the normal state while the indexes of cellular composition returned to the level of control values which was conditioned by immunocorrecting properties of the drug studied.
Sapin
M R
MR
Department of Bioorganic Chemistry, East-Siberian State Technological University, Ulan-Ude.
Lamazhapova
G P
GP
Zhamsaranova
S D
SD
Grigorenko
D E
DE
Erofeeva
L M
LM
D000818:Animals; D001379:Azathioprine / Q000633:toxicity; D002432:Cecum / Q000473:pathology*; D002452:Cell Count; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000633:toxicity; D007413:Intestinal Mucosa / Q000473:pathology*; D008081:Liposomes / Q000627:therapeutic use*; D008221:Lymphoid Tissue / Q000473:pathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D007166:Immunosuppressive Agents; D008081:Liposomes; D001379:Azathioprine