Pathobiology of pulmonary hypertension. The role of platelets and thrombosis.
With the rare exceptions of PAH associated with antiphospholipid antibodies, genetic platelet dysfunction, or inherited deficiencies of antithrombotic pathways, the thrombotic lesions are secondary, but frequently occurring, in most cases of primary or secondary PAH. Pulmonary arterial hypertension is associated with thrombotic lesions and persistent vasoconstriction and structural remodeling of PA. Activated platelets interact with the PA wall and may contribute to the functional and structural alterations of pulmonary vessels by releasing vasoactive factors and mitogenic mediators.
Herve
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P
Service de Pneumologie et Réanimation Respiratoire, Centre des Maladies Vasculaires Pulmonaires, Hôpital Antoine Béclère et Hôpital Marie Lannelongue, Université Paris Sud, Clamart, France. pherve@ccml.com
Humbert
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M
Sitbon
O
O
Parent
F
F
Nunes
H
H
Legal
C
C
Garcia
G
G
Simonneau
G
G
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D019774:Blood Coagulation Factor Inhibitors / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology*; D016228:Endothelial Growth Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000503:physiopathology; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology* / Q000503:physiopathology*; D008222:Lymphokines / Q000502:physiology; D015539:Platelet Activation / Q000502:physiology; D012307:Risk Factors; D012701:Serotonin / Q000502:physiology; D013927:Thrombosis / Q000503:physiopathology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D019774:Blood Coagulation Factor Inhibitors; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D012701:Serotonin