The INK4a/ARF network in tumour suppression.
The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.
Sherr
C J
CJ
Department of Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA. sherr@stjude.org
D020823:ADP-Ribosylation Factor 1 / Q000502:physiology*; D000818:Animals; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000502:physiology*; D016161:Genes, Retinoblastoma; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000517:prevention & control*; D015398:Signal Transduction
D019941:Cyclin-Dependent Kinase Inhibitor p16; D020823:ADP-Ribosylation Factor 1