Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds.
We report the anti-Chagasic activity of the natural dihydrostilbenoid isonotholaenic acid and several simple derivatives, as well as that of some representative compounds of related synthetic series, with basic structures of benzalphthalides, dihydrostilbamides, isoindoles, phthalazin-1-ones, imidazo[2,1-a]isoindoles and pyrimido[2,1-a]isoindoles. The evaluation was performed in vitro on cultures of epimastigote and trypomastigote forms of Trypanosoma cruzi. Some of the tested compounds resulted to be as potent as benznidazole (epimastigotes), and others were shown to be more active than gentian violet (trypomastigotes), used as reference drugs.
del Olmo
E
E
Departamento de Química Farmacéutica, Facultad de Farmacia, 37007, Salamanca, Spain. olmo@usal.es
Armas
M G
MG
López-Pérez
J L
JL
Ruiz
G
G
Vargas
F
F
Giménez
A
A
Deharo
E
E
San Feliciano
A
A
D000818:Animals; D021261:Parasitic Sensitivity Tests; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D013267:Stilbenes; D014344:Trypanocidal Agents