title: Retrospective comparison of the AJCC 5th edition classification for nasopharyngeal carcinoma with the AJCC 4th edition: an experience in Taiwan.
abstract: OBJECTIVE
  The aim of this study was to compare the new AJCC 5th edition classification system for nasopharyngeal carcinoma (NPC) with the AJCC 4th edition by re-evaluating the staging of patients treated in Taiwan.
  
  
  METHODS
  From 1992 through 1996, 117 NPC patients without distant metastasis were treated using complete courses of radiotherapy. All patients had complete CT examinations of the nasopharynx and neck. Each patient was re-staged according to the 5th edition of the AJCC classification system. Their overall survival (OS), loco-regional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS) and disease-free survival (DFS) were compared between the two staging systems, using the Kaplan-Meier method, log-rank test, Wilcoxon test and Cox proportional hazard model.
  
  
  RESULTS
  After a median follow-up of 58.3 months, the 5-year OS for stage I, II, III and IV was 88, 86, 61 and 48%, respectively, according to the new staging. A more even distribution of patients was noted among the patients classified according to the AJCC 5th edition than the 4th edition. The distribution of stages I, II, III and IV was 13.7, 37.6, 15.4 and 33.3%, respectively, using the new staging system, whereas it was 0.8, 14.5, 20.5 and 64.2%, respectively, using the old staging system. More statistically significant differences among 5th edition stages and T classifications than the 4th edition were also noted.
  
  
  CONCLUSIONS
  The 5th edition of the AJCC staging system appears to have a more even distribution of patients and more statistically significant differences in predicting prognosis than the 4th edition, mostly in stages and T classification.
authors.affiliation: Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
authors.forename: C R
authors.initials: CR
authors.lastname: Chien
authors.forename: S W
authors.initials: SW
authors.lastname: Chen
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsieh
authors.forename: J A
authors.initials: JA
authors.lastname: Liang
authors.forename: S N
authors.initials: SN
authors.lastname: Yang
authors.forename: C Y
authors.initials: CY
authors.lastname: Huang
authors.forename: F J
authors.initials: FJ
authors.lastname: Lin
mesh_terms: D018572:Disease-Free Survival; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000145:classification* / Q000000981:diagnostic imaging / Q000473:pathology; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging / Q000379:methods*; D012189:Retrospective Studies; D016019:Survival Analysis; D013624:Taiwan; D014057:Tomography, X-Ray Computed