How many nuclear hormone receptors are there in the human genome?
The sequence of the human genome now allows the definition of the complete set of genes for specific protein families in humans. Because of their involvement in many physiological and pathological processes, the nuclear hormone receptors are a superfamily of crucial medical significance. Although 48 human nuclear receptor genes were identified previously, their total number is unclear from early human genome reports. Here, we report the identification and classification of all nuclear receptor genes in the human genome, and we discuss corresponding transcriptome and proteome diversity.
Robinson-Rechavi
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CNRS UMR 5665, Laboratoire de Biologie Moléculaire et Cellulaire, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 cedex 07, Lyon, France. marc.robinson@ens-lyon.fr
Carpentier
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Duffraisse
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Laudet
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D017398:Alternative Splicing; D030541:Databases, Genetic; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D020543:Proteome; D011544:Pseudogenes; D018160:Receptors, Cytoplasmic and Nuclear / Q000145:classification / Q000235:genetics*; D012985:Software Design
D020543:Proteome; D018160:Receptors, Cytoplasmic and Nuclear