title: The LRR proteins capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing.
abstract: Mechanisms to segregate cell populations play important roles in tissue patterning during animal development. Rhombomeres and compartments in the ectoderm and imaginal discs of Drosophila are examples in which initially homogenous populations of cells come to be separated by boundaries of lineage restriction. Boundary formation depends in part on signaling between the distinctly specified cell populations that comprise compartments and in part on formation of affinity boundaries that prevent intermingling of these cell populations. Here, we present evidence that two transmembrane proteins with leucine-rich repeats, known as Capricious and Tartan, contribute to formation of the affinity boundary between dorsal and ventral compartments during Drosophila wing development.
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Milán
authors.forename: U
authors.initials: U
authors.lastname: Weihe
authors.forename: L
authors.initials: L
authors.lastname: Pérez
authors.forename: S M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002470:Cell Survival; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development*; D029721:Drosophila Proteins; D017353:Gene Deletion; D006579:Heterozygote; D007301:Insect Hormones / Q000235:genetics / Q000502:physiology; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D014921:Wings, Animal / Q000033:anatomy & histology / Q000166:cytology / Q000254:growth & development*
chemical_list: D029721:Drosophila Proteins; D007301:Insect Hormones; D019476:Insect Proteins; D008565:Membrane Proteins; C113006:caps protein, Drosophila; C084647:trn protein, Drosophila