Human herpesvirus 6 downregulates major histocompatibility complex class I in dendritic cells.
The expression of major histocompatibility complex (MHC) class I, class II, CD1a, and CD 83 in dendritic cells (DCs) after infection with human herpesvirus 6 (HHV-6) was examined. Whereas there was no significant change in the expression of CD1a, CD83, and MHC class II in infected DCs, MHC class I expression was downregulated after infection with HHV-6 variant A but not HHV-6B. The expression of HHV-6 immediate-early or early genes was required for the downregulation of MHC class I. The de novo synthesis of MHC class I was greatly suppressed by infection with HHV-6A in DCs, while its rate of degradation was only slightly elevated. These results suggest that HHV-6A may escape from the host immune system in DCs by causing the downregulation of MHC class I synthesis.
Hirata
Y
Y
Department of Microbiology, Osaka University Medical School, Yamada-oka, Suita, Osaka 565-0871, Japan.
Kondo
K
K
Yamanishi
K
K
D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology*; D015536:Down-Regulation; D005434:Flow Cytometry; D015654:Herpesvirus 6, Human / Q000472:pathogenicity* / Q000502:physiology; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis*; D006801:Humans; D011233:Precipitin Tests; D014779:Virus Replication
D016207:Cytokines; D015395:Histocompatibility Antigens Class I