title: Transmission of hepatitis A in hamburg, germany, 1998-1999--A prospective population based study.
abstract: To study the pattern of transmission of HAV in a large urban community a prospective cohort study was conducted in Hamburg between 1 January 1998 and 31 December 1999. Four hundred and eleven patients were classified as hepatitis A cases comprising 144 foreign and 267 German persons. Univariate analyses were carried out to examine differences between socio-demographic, clinical and behavioural characteristics. To determine independent predictors for HAV infection a multiple logistic-regression model was used. The principal risk factor was travel to areas where hepatitis A is endemic, with 32.6% (n= 134/411) of all documented cases of hepatitis A. Foreign patients who had acquired the infection abroad, mostly children, accounted for the majority of these cases. Of all 411 cases, 42 (10.2%) were associated with parenteral drug, followed by day-care or school contact (8.3%; n = 34). Outbreaks contributed to 11.4% of cases (n = 47), but only 7.1% (n = 29) were household contacts. The low incidence rate among exposed persons in the households of those infected was similar in the groups of foreign and German nationals (17/384 = 4.4% and 12/231 = 5.2%, respectively), which may demonstrate a good hygienic level in general. Our findings suggest that preventive measures such as the improvement of hygienic conditions in a defined general population may contribute to a reduced incidence of hepatitis A. Nevertheless, because hygienic standards may change with time, this policy should be supplemented by targeted vaccination of groups at risk.
authors.affiliation: School of Public Health, University of Düsseldorf, Germany. rol.diel@t-online.de
authors.forename: R
authors.initials: R
authors.lastname: Diel
authors.forename: S
authors.initials: S
authors.lastname: Schneider
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002656:Child Day Care Centers; D002669:Child Welfare; D002675:Child, Preschool; D004196:Disease Outbreaks; D005191:Family Characteristics; D005858:Germany / Q000453:epidemiology; D006506:Hepatitis A / Q000635:transmission*; D006801:Humans; D015994:Incidence; D007223:Infant; D007229:Infant Welfare; D007231:Infant, Newborn; D008875:Middle Aged; D011159:Population Surveillance; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012572:School Health Services; D019966:Substance-Related Disorders / Q000150:complications; D014195:Travel; D014504:Urban Health