Combinatorial libraries and biological discovery.
Combinatorial chemistry has become a popular tool for the preparation of collections of compounds that can be used to find inhibitors and substrates for different protein targets. It has evolved to provide small molecule libraries, which, with the concomittant use of affinity chromatography, gene expression profiling and complementation, can be used to identify compounds and their protein targets in biological systems, including the neurological system.
Gray
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Novartis Institute of Functional Genomics, 3115 Merryfield Row Suite 200, 92121-1125, San Diego, CA 92121-1125, USA. gray@gnf.org
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D019151:Peptide Library
D019151:Peptide Library