title: Helium and other alternative insufflation gases for laparoscopy.
abstract: BACKGROUND
  Carbon dioxide (CO(2)) is currently the insufflation gas of choice for laparoscopy. It fulfills most of the requirements for an ideal insufflation gas, being colorless, noninflammable, and rapidly excreted from the circulation. However, its use is associated with adverse cardiorespiratory effects, especially in patients with preexisting cardiorespiratory compromise.
  
  
  METHODS
  The descriptive review of relevant literature, moreover, has been proposed that it increases the incidence of port site (wound) metastases from abdominal cancers when used during oncological surgery. In addition, it may cause postoperative pain due to peritoneal irritation, and its use is associated with physiological and immunological impairment. Hence, there is scope for the investigation of alternative insufflation gases. Other possibilities include gasless laparoscopy, helium, nitrous oxide, (N(2)O), and argon. Helium insufflation has been used extensively in animal models but only to a limited extent in humans. In experimental studies, it has been shown to produce fewer changes in cardiorespiratory and intraperitoneal immunological status than CO(2) insufflation, and its use is associated with less spread of tumors to port sites in a variety of small animal tumor models. However, helium also has the potential for some adverse effects. Helium pneumothorax probably resolves more slowly than CO(2) pneumothorax, and helium gas embolism is tolerated poorly in animal models. The clinical significance of these potential problems has yet to be determined.
  
  
  CONCLUSIONS
  Although the use of alternative gases appears to be promising, further evaluation is needed within both clinical and laboratory settings before their routine clinical use can be supported.
authors.affiliation: Department of Surgery, The University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia.
authors.forename: S J
authors.initials: SJ
authors.lastname: Neuhaus
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: D I
authors.initials: DI
authors.lastname: Watson
mesh_terms: D000008:Abdominal Neoplasms / Q000601:surgery; D000818:Animals; D002245:Carbon Dioxide; D006371:Helium / Q000008:administration & dosage*; D006801:Humans; D007327:Insufflation / Q000009:adverse effects / Q000379:methods*; D010535:Laparoscopy / Q000379:methods*; D011031:Pneumothorax, Artificial / Q000009:adverse effects / Q000379:methods
chemical_list: D002245:Carbon Dioxide; D006371:Helium