[Role of the pathologist in management of familial cancers].
Pathologists have long been in charge of the morphological analysis of human cancers, and have been used to be at the end of a chain in the diagnostic procedure. With the search for somatic mutations and new prognostic markers, the pathologists have become key-members in oncogenetics. New modalities for tissue fixation, microdissection of tumors, and forwarding of specimens to the molecular biologists are therefore requested. Two examples are presented to illustrate the need for tumor DNA, with the diagnostic utility of a microsatellite testing as a prescreening test in HNPCC tumors, and the search for new prognostic markers in some inherited predispositions to breast cancers.
Sabourin
J C
JC
Département de Pathologie, Institut Gustave-Roussy, 39, rue Camille-Desmoulins, 94800 Villejuif. sabourin@igr.fr
D019342:Acetic Acid; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000473:pathology; D020732:Cytogenetic Analysis / Q000379:methods*; D004273:DNA, Neoplasm / Q000235:genetics; D004210:Dissection / Q000379:methods; D005557:Formaldehyde; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D009154:Mutation / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D010338:Pathology, Clinical / Q000379:methods*; D010819:Physician's Role; D010851:Picrates; D011379:Prognosis; D012017:Referral and Consultation; D015203:Reproducibility of Results
D004273:DNA, Neoplasm; D005819:Genetic Markers; D010851:Picrates; D005557:Formaldehyde; C026239:Bouin's solution; D019342:Acetic Acid