Survival following Burkholderia cepacia sepsis in a patient with cystic fibrosis treated with corticosteroids.
We describe an 11-year-old girl with cystic fibrosis (CF) who presented with respiratory failure and Burkholderia cepacia bacteremia (cepacia syndrome). She survived her illness after aggressive treatment with parenteral antibiotics and corticosteroids. We speculate that treatment with corticosteroids may decrease the influx of proinflammatory cytokines and neutrophil-induced inflammation, with resulting improvement in the outcome of cepacia syndrome in CF patients.
Kazachkov
M
M
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7220, USA.
Lager
J
J
LiPuma
J
J
Barker
P M
PM
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D016470:Bacteremia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D019121:Burkholderia Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016956:Burkholderia cepacia / Q000302:isolation & purification*; D002648:Child; D003131:Combined Modality Therapy; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage*; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone