title: Mental stimulation increases circulating CD4-positive T lymphocytes: a preliminary study.
abstract: To stimulate the dorsolateral frontal cortex, 12 healthy, adult, human females played contract bridge for 1.5 h between initial and final blood sample collections. Flow cytometric analyses of samples, performed in triplicate, showed a significant increase in CD4-positive T lymphocytes. The dorsolateral frontal cortical thickness is significantly and bilaterally reduced in immune-incompetent female, nude mice. Thymic transplants reverse the deficient cortical thickness and CD4-positive cell numbers.
authors.affiliation: Department of Integrative Biology, 3060 Valley Life Sciences Building, University of California, Berkeley, CA 94720-3140, USA. diamond@socrates.berkeley.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Diamond
authors.forename: J
authors.initials: J
authors.lastname: Weidner
authors.forename: P
authors.initials: P
authors.lastname: Schow
authors.forename: S
authors.initials: S
authors.lastname: Grell
authors.forename: M
authors.initials: M
authors.lastname: Everett
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology*; D005260:Female; D005434:Flow Cytometry; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D008606:Mental Processes / Q000502:physiology*; D051379:Mice; D008819:Mice, Nude; D015213:Neuroimmunomodulation / Q000502:physiology*; D010865:Pilot Projects