Multiple acyl-CoA dehydrogenase deficiency: a rare cause of acidosis with an increased anion gap.
Metabolic acidosis is encountered frequently in intensive care and common causes include lactic acidosis, ketoacidosis, or renal failure. We describe a patient presenting to intensive care with a rare cause of metabolic acidosis associated with an increased anion gap: multiple acyl-CoA dehydrogenase deficiency. The pathophysiology of this condition is discussed along with potential treatment options.
Grice
A S
AS
Department of Anaesthetics, Poole General Hospital, UK.
Peck
T E
TE
D000136:Acid-Base Equilibrium / Q000502:physiology*; D000138:Acidosis / Q000201:enzymology* / Q000503:physiopathology; D044944:Acyl-CoA Dehydrogenases / Q000172:deficiency*; D000328:Adult; D003422:Critical Care; D005260:Female; D006801:Humans
D044944:Acyl-CoA Dehydrogenases