[Modulating effects of exogenous histamine, serotonin, and heparin on leukocytic reaction during inflammation].
On the model of E. coli-induced acute infectious peritonitis in rats previously depleted on mast cells of peritoneal cavity the replacing effects of various doses of exogenous histamine, serotonin and heparin and their complex on leukocytic reaction of inflammatory focus and blood were studied. In was shown that all of the used substances had a meaning in the mechanisms of modulating effect of mast cells on leukocytes. The analogous on direction to mast cells ones effects on leukocytes were produced mostly by histamine and especially by the complex of substances.
Klymenko
M O
MO
Kharkov State Medical University, Ministry of Public Health of Ukraine.
Pyshnov
H Iu
HIu
D000818:Animals; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000503:physiopathology*; D006493:Heparin / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D007249:Inflammation / Q000503:physiopathology; D007962:Leukocytes / Q000502:physiology*; D008297:Male; D008407:Mast Cells / Q000502:physiology; D010538:Peritonitis / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D006632:Histamine; D006493:Heparin