Use of topical ketanserin for the treatment of ulcers in leprosy patients.
A comparative study was carried out in which 66 leprosy patients with ulcers were randomly divided in two groups of 33 patients each: Group A (experimental group) was treated with ketanserin gel (2%) and group B with clioquinol cream and/or Lassar paste during a three month period. At the end of the study, when ulcer sizes in the two groups were compared, the group treated with topical ketanserin showed superior results (p < 0.001 using Kolmogorov-Smirnov's test). We conclude that the drug is useful as coadjuavant treatment for healing ulcers in these patients.
Salazar
J J
JJ
Dermatologic Institute Guanajuatense, Viveros Revolución S/N Irapuato, Gto, Mexico.
Serrano
G G
GG
Leon-Quintero
G I
GI
Torres-Mendoza
B M
BM
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007650:Ketanserin / Q000008:administration & dosage / Q000627:therapeutic use*; D007918:Leprosy / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000188:drug therapy*; D016896:Treatment Outcome
D012702:Serotonin Antagonists; D007650:Ketanserin