Changes in steroid receptor activation, cell kinetics and tumor growth rate, during progression of human endometrial adenocarcinomas growing in nude mice: a brief review.
Our findings concerning changes in steroid receptor activation, cell kinetics and tumor growth during progression of human endometrial adenocarcinomas heterotransplanted into nude mice were reviewed. We found several major changes during the course of progression of these tumors. Such alterations as changes in estrogen receptor function, post-receptor changes and intratumor endocrine interactions were identified. Our results suggest moreover, that development of these alterations is probably genetically determined though some of the changes may be modified by the level of circulating estradiol concentrations. Through influenced tumor progression, the level of circulating estradiol may also affect hormone treatment of human endometrial adenocarcinomas.
Horvath
G.
G
Division of Gynecologic Oncology, Department of Oncology, Sahlgren's University Hospital, Gothenburg, Sweden.