[Investigation of N-acylethanolamines on adrenal cortex function].
The possibility of NAE to take part in the regulation of the function of adrenal glands was studied. It was shown that two times NAE (18:0) injection in a dose 5 mg/kg of weight increased the content of 11-hydroxysteroids in blood of intact male rats. NAE caused the raise of the blood hormone content in 4 fold under the immobilization stress. It is apparent that augment of stress response under the influence of NAE in vivo is explained by the activation of hypophysis-adrenal cortex system. In vitro NAE lowered steroidogenesis by near 40%. One can suggest that this decrease is caused by membranotropic properties of NAE.
Hula
N M
NM
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine. ngula@biochem.kiev.ua
Mikosha
O S
OS
Zhukov
O D
OD
Chelnakova
I S
IS
D000302:Adrenal Cortex / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D004983:Ethanolamines / Q000494:pharmacology*; D007103:Immobilization; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D004983:Ethanolamines; C022203:N-acylethanolamines