title: Studies on the synthesis and biological activity of 3-arylaminomethyl-5-(3-pyridyl)-1,3,4-oxadiazole-2-thione derivatives.
abstract: 3-arylaminomethyl-5-(3-pyridyl)-1,3,4-oxadiazole-2-thiones were prepared by reaction of 5-(3-pyridyl)-1,3,4-oxadiazole-2-thione with formaldehyde and appropriate alky and aryl amines in ethanol, as potential biological active agents. These new synthesized Mannich bases were screened for their antimicrobial, antifungal and antiinflammatory activities.
authors.affiliation: Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Mangalore, India.
authors.forename: D
authors.initials: D
authors.lastname: Satyanarayana
authors.forename: S
authors.initials: S
authors.lastname: Gorge
authors.forename: E V
authors.initials: EV
authors.lastname: Subrahmanyam
authors.forename: B
authors.initials: B
authors.lastname: Kalluraya
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005658:Fungi / Q000187:drug effects; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D010069:Oxadiazoles; D011725:Pyridines