title: Tuned aperture computed tomography to evaluate osseous healing.
abstract: Quantification of osseous healing is a challenging task, requiring expensive advanced imaging modalities. To improve diagnostic osseous imaging, we undertook this prospective study to explore the potential of Tuned Aperture Computed Tomography. Eighty defects in 20 rabbit mandibles, randomly carrying an osteoblast suspension or a polymer matrix or a combination thereof or no treatment, were imaged at 3, 6, 9, and 12 weeks post-surgery. TACT slices, iteratively restored TACT, and conventional digital radiographs were evaluated. Mean-gray-value distribution within regions of interest was correlated with histomorphometric data. Lesions treated with osteoblast/polymer-matrix delivery systems demonstrated the highest mean gray-value, while the diagnostic efficacy of TACT-IR was significantly better than that of other imaging modalities (p < 0.001). Thus, TACT is an accurate imaging modality for non-destructive quantification of osseous dynamics.
authors.affiliation: Oral and Maxillofacial Radiology, Periodontics, Oral Biology, University of Pittsburgh, PA 15261-1923, USA. mkn2@pitt.edu
authors.forename: M K
authors.initials: MK
authors.lastname: Nair
authors.forename: A
authors.initials: A
authors.lastname: Seyedain
authors.forename: S
authors.initials: S
authors.lastname: Agarwal
authors.forename: R L
authors.initials: RL
authors.lastname: Webber
authors.forename: U P
authors.initials: UP
authors.lastname: Nair
authors.forename: N P
authors.initials: NP
authors.lastname: Piesco
authors.forename: M P
authors.initials: MP
authors.lastname: Mooney
authors.forename: H G
authors.initials: HG
authors.lastname: Grondahl
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials; D021621:Imaging, Three-Dimensional; D019344:Lactic Acid; D008334:Mandible / Q000601:surgery; D010006:Osteoblasts / Q000502:physiology; D010012:Osteogenesis; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D011446:Prospective Studies; D011817:Rabbits; D011897:Random Allocation; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid