[The effects of allitridum on the proliferation of rabbit aortic smooth muscle cells in vitro].
The effects of allitridum on the proliferation of cultured rabbit aortic smooth muscle cells (SMC) were studied with SMC incorporation data of 3H-thymidine(3H-TdR) and contents of superoxide dismutase(SOD), lipid peroxide(LPO), prostacyclin(PGI2) and cyclic adenosine monophosphate(cAMP) in medium. The results showed that allitridum could inhibit SMC proliferation by increasing SOD activity, decreasing LPO, raising PGI2 and cAMP(all P < 0.05-0.01), and the inhibitory action was accompanied by the dose-effect relation.
Li
Z
Z
Department of Cardiology, First Affiliated Hospital of Hubei Medical University, Wuhan 430060.
Li
G
G
Huang
C
C
Xu
J
J
Jiang
H
H
D000498:Allyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001011:Aorta / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000378:metabolism; D005737:Garlic / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008315:Malondialdehyde / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D011817:Rabbits; D013440:Sulfides / Q000302:isolation & purification / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D000498:Allyl Compounds; D000975:Antioxidants; D000960:Hypolipidemic Agents; D013440:Sulfides; C042577:diallyl trisulfide; D008315:Malondialdehyde; D011464:Epoprostenol; D013482:Superoxide Dismutase