title: Painful multifocal arthritis: therapy with rhenium 186 hydroxyethylidenediphosphonate ((186)Re HEDP) after failed treatment with medication--initial results of a prospective study.
abstract: Eight patients (77 joints) with polyarthritis were treated systemically with 570 MBq (15.4 mCi) of rhenium 186 ((186)Re) hydroxyethylidenediphosphonate (HEDP). Pain and disease activity were assessed monthly. In six (75%) of eight patients, a single injection of (186)Re HEDP led to an improvement in disease activity. Systemic low-dose treatment with (186)Re HEDP can reduce pain and disease activity in patients with polyarthritis.
authors.affiliation: Department of Nuclear Medicine, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. palmedo@mailer.med.uni-bonn.de
authors.forename: H
authors.initials: H
authors.lastname: Palmedo
authors.forename: J K
authors.initials: JK
authors.lastname: Rockstroh
authors.forename: M
authors.initials: M
authors.lastname: Bangard
authors.forename: K
authors.initials: K
authors.lastname: Schliefer
authors.forename: J
authors.initials: J
authors.lastname: Risse
authors.forename: C
authors.initials: C
authors.lastname: Menzel
authors.forename: H J
authors.initials: HJ
authors.lastname: Biersack
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000532:radiotherapy*; D012968:Etidronic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010146:Pain / Q000188:drug therapy; D059408:Pain Management; D011446:Prospective Studies; D011868:Radioisotopes / Q000627:therapeutic use*; D012211:Rhenium / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D009942:Organometallic Compounds; D011868:Radioisotopes; C101598:rhenium-186 HEDP; D012211:Rhenium; D012968:Etidronic Acid