Polymorphism of the human muc genes.
Mucins encoded by the MUC genes share the common feature of having an extensive tandem repeat region that encompasses a large proportion of the coding sequence. In many of the genes this tandem repeat region shows a great deal of allelic length variation and recently studies have demonstrated person to person variation in pattern of nucleotide or amino-acid changes in the repeat units. The length and sequence variability will be discussed in this review, as will its role in disease susceptibility.
Fowler
J
J
Galton Laboratory, Department of Biology, Wolfson House, 4 Stephenson Way, London NW1 2HE.
Vinall
L
L
Swallow
D
D
D006801:Humans; D018598:Minisatellite Repeats / Q000235:genetics; D009077:Mucins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D020033:Protein Isoforms / Q000235:genetics
D009077:Mucins; D020033:Protein Isoforms