title: [Fatal necro-hemorrhagic pancreatitis related to sodium valproate: case report].
abstract: Among the idiosyncratic reactions related to VPA, pancreatitis is the most rare and less remembered even though its potentially fatal course. We report the case of a 5 year-old boy with epilepsy treated with VPA 40 mg/kg/day associated with CBZ 20 mg/kg/day and PB 3 mg/kg/day, admitted for vomiting, abdominal pain, low grade fever, abdominal tension and amylasis of 288 UI. On evolution presented upper digestive hemorrhage, shock and amylasis of 564 UI. The patient was submitted to exploratory laparotomy with findings of hemorrhagic ascitis, retroperitoneal hematoma, increased volume of pancreas with edema and hemorrhage leading to diagnosis of necro-hemorrhagic pancreatitis and a fatal course. Pancreatic complications are well known complications related to VPA treatment and may vary between asymptomatic hyperamilasemy to fatal acute pancreatitis. The characteristics of our patient correlates with the data on literature: we found 7 similar cases reported, 4 of which died.
authors.affiliation: Serviço de Neuropediatria, Hospital Infantil Pequeno Príncipe, Curitiba, PR, Brasil.
authors.forename: R P
authors.initials: RP
authors.lastname: Munhoz
authors.forename: M L
authors.initials: ML
authors.lastname: dos Santos
authors.forename: O J
authors.initials: OJ
authors.lastname: Hernández-Fustes
mesh_terms: D000208:Acute Disease; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009336:Necrosis; D010195:Pancreatitis / Q000139:chemically induced* / Q000473:pathology; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid