title: Cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders.
abstract: The reliability of cerebrospinal fluid (CSF)-tau and CSF-beta-amyloid assays for diagnosis of Alzheimer's disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) is reviewed. CSF assessment of the two proteins is useful in early diagnosis of AD and to differentiate it from FTD and DLB. Extremely high CSF-tau levels can discriminate CJD from AD.
authors.affiliation: Innogenetics NV, Industriepark Zwijnaarde 7, Box 4, B-9052, Ghent, Belgium. eugeevme@innogenetics.com
authors.forename: E
authors.initials: E
authors.lastname: Vanmechelen
authors.forename: H
authors.initials: H
authors.lastname: Vanderstichele
authors.forename: F
authors.initials: F
authors.lastname: Hulstaert
authors.forename: N
authors.initials: N
authors.lastname: Andreasen
authors.forename: L
authors.initials: L
authors.lastname: Minthon
authors.forename: B
authors.initials: B
authors.lastname: Winblad
authors.forename: P
authors.initials: P
authors.lastname: Davidsson
authors.forename: K
authors.initials: K
authors.lastname: Blennow
mesh_terms: D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D006801:Humans; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D013997:Time Factors; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins