title: The penetration of cefoperazone and sulbactam into the lumbar intervertebral discs.
abstract: Six patients received 1 g and six other patients received 2 g of cefoperazone and sulbactam 15 minutes before lumbar disc surgery. Liquid chromatographic analysis of disc tissue revealed that only patients receiving the 2-g dose had mean tissue levels above the minimum inhibitory concentration for Staphylococcus aureus and epidermidis.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Selçuk University, Konya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Köroğlu
authors.forename: O
authors.initials: O
authors.lastname: Acar
authors.forename: M E
authors.initials: ME
authors.lastname: Ustün
authors.forename: B
authors.initials: B
authors.lastname: Tiraş
authors.forename: O
authors.initials: O
authors.lastname: Eser
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002438:Cefoperazone / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D004359:Drug Therapy, Combination; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism*; D008159:Lumbar Vertebrae / Q000378:metabolism; D013407:Sulbactam / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002438:Cefoperazone; D013407:Sulbactam