[Insulin resistance index: measurement and potential in human reproduction].
Insulin resistance (IRI) applies to abnormalities of insulin-stimulated glucose metabolism. Biochemical events related to this phenomenon are difficult to search in the absence of overt diabetes mellitus. A simple method to quantify insulin resistance was assessed through the measurement of glucose and insulin (fasting glucose [mmol/L] x fasting insulin [mU/L]/22.5) in patients (n = 50) attending our clinic of human reproduction, including controls (n = 10) and diabetics either unstable or under control (n = 5). Cases with obesity, polycystic ovarian disease, diabetes mellitus, infertility and hypoglycemia showed higher (p = 0.01-0.05) IRI changes, inversely correlated with a decreasing fasting glucose observed in diabetics under treatment with various degrees of control. We conclude that the IRI method used in this work is a reliable estimate of insulin resistance with potential applications for the study of reproductive biology.
Ayala
A R
AR
Departamento, Biología de la Reproducción Humana, Dirección de Investigación y Enseñanza, Hospital Juárez de México, SSA., México, D.F.
Saad
A
A
Padrón
M L
ML
Tovar Rodríguez
J M
JM
D001786:Blood Glucose / Q000032:analysis*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood
D001786:Blood Glucose