Retinoids for the treatment of psoriasis: outlook for the future.
Despite the demonstrated clinical success of retinoid therapy in psoriasis, its mechanism of action has not been fully elucidated, and investigators are confronted with two paradoxes. Firstly, the binding of retinoids to nuclear retinoic acid receptors (RARs) does not match their therapeutic efficacy. Secondly, formation of retinoic acid is probably increased in the psoriatic lesions. Answering these questions should result in: (i) the better use of acitretin, an oral synthetic retinoid, and tazarotene, the first compound for topical use; (ii) the development of new retinoids with specific pharmacological profile such as subtype-selective retinoids including molecules with an 'antiretinoid' activity and dissociating antiproliferative retinoids; and (iii) the better characterization of non-genomic effects of retinoids.
Kuenzli
S
S
Department of Dermatology, University Hospital, Geneva, Switzerland.
Saurat
J H
JH
D000818:Animals; D006801:Humans; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy*; D012176:Retinoids / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014467:Ultraviolet Therapy
D012176:Retinoids