title: Optic neuritis: a novel presentation of Schilder's disease.
abstract: The clinical features of a 7-year-old girl who presented with unilateral optic neuritis are presented. Magnetic resonance imaging (MRI) showed lesions in the affected optic nerve and the centrum semiovale bilaterally. Biopsy of one of the cerebral lesions was consistent with a diagnosis of Schilder's disease. Visual acuity returned to normal, and the demyelinating MRI lesions improved markedly with corticosteroid treatment. Optic neuritis is a novel mode of presentation in Schilder's disease.
authors.affiliation: Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242, USA. adel_afifi@uiowa.edu
authors.forename: A K
authors.initials: AK
authors.lastname: Afifi
authors.forename: K A
authors.initials: KA
authors.lastname: Follett
authors.forename: J
authors.initials: J
authors.lastname: Greenlee
authors.forename: W E
authors.initials: WE
authors.lastname: Scott
authors.forename: S A
authors.initials: SA
authors.lastname: Moore
mesh_terms: D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009900:Optic Nerve / Q000473:pathology; D009902:Optic Neuritis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology