title: Peritoneal carcinomatosis: image-guided peritoneal core biopsy for tumor type and patient care.
abstract: OBJECTIVE
  To assess image-guided peritoneal core biopsy for the diagnosis of tumor type and treatment of patients with peritoneal carcinomatosis.
  
  
  METHODS
  Thirty-five women (age range, 47-85 years; mean age, 69 years) prospectively identified in a gynecologic oncology center underwent 18-gauge core biopsy in omental cake (n = 25), peritoneal (n = 7), or adnexal (n = 3) sites. No complications of biopsy occurred. Standard hematoxylin-eosin analysis of the biopsy cores was supplemented by immunohistochemical markers to CA-125, carcinoembryonic antigen, cytokeratin 7, and cytokeratin 20. Diagnoses were validated with further multidisciplinary review, subsequent surgery, and response to specific chemotherapy.
  
  
  RESULTS
  In 27 (77%) of the 35 women, a confident primary site diagnosis was obtained with standard hematoxylin-eosin analysis of core biopsy material from the following sites: ovary (n = 22), breast (n = 2), colon (n = 2), and lymphoma (n = 1). The finding at hematoxylin-eosin analysis in another seven (20%) women was poorly differentiated adenocarcinoma with no definite primary site but with an immunohistochemical profile suggesting ovarian cancer (CA-125 positive, carcinoembryonic antigen negative, cytokeratin 7 positive, cytokeratin 20 negative). There was one false-negative biopsy result.
  
  
  CONCLUSIONS
  Image-guided peritoneal core biopsy with hematoxylin-eosin analysis supplemented with immunohistochemical analysis is a simple, safe, and accurate technique for providing site-specific diagnoses in women with undiagnosed peritoneal carcinomatosis.
authors.affiliation: Department of Clinical Radiology, St James's University Hospital, Beckett St, Leeds LS9 7TF, England. wilsonspencer@compuserve.com
authors.forename: J A
authors.initials: JA
authors.lastname: Spencer
authors.forename: S E
authors.initials: SE
authors.lastname: Swift
authors.forename: N
authors.initials: N
authors.lastname: Wilkinson
authors.forename: A P
authors.initials: AP
authors.lastname: Boon
authors.forename: G
authors.initials: G
authors.lastname: Lane
authors.forename: T J
authors.initials: TJ
authors.lastname: Perren
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed