title: Surgical complications and treatment during resection for malignancy of the high bile duct.
abstract: From January 1968 to January 1997 a series of 50 of 109 patients had undergone resection for high bile duct cancer in our institution in Rennes, France. The overall operative mortality was 12%, but there were no deaths among those who had only tumor resection or those with hepatectomy with vascular reconstruction. The early complications were biliary fistula (four cases) and subphrenic abscess (three cases), of which two of the biliary fistulas resulted in mortality. There were three gastrointestinal hemorrhages; one was due to gastritis related to hepatorenal insufficiency and was fatal. Two other deaths were due to respiratory failure and ascites associated with hepatic insufficiency. In one patient after liver transplantation with cluster resection, a biliary leak and ileocolic fistula were the cause of postoperative mortality. Another patient suffered a ruptured mycotic aneurysm after pretransplant transtumoral intubation, which emphasizes the risk of infection in an immunosuppressed patient. The main late complication was cholangitis (8 cases). This complication is most often a symptom of recurrence (four cases). Some are due to benign causes (intrahepatic lithiasis, intrahepatic foreign body granuloma). Surgical exploration is mandatory to exclude benign complications, which can then be treated palliatively. Four patients presented with recurrence but without cholangitis. In conclusion, the causes of complications after resection of high bile duct cancer should be carefully assessed to choose the correct treatment. Late cholangitis is a symptom of recurrence, but it should be explored and managed precisely.
authors.affiliation: Department d'Oncologie Chirurgicale, Centre Eugene Marquis, Rennes, France. bernard.meunier@chu-rennes.fr
authors.forename: B
authors.initials: B
authors.lastname: Meunier
authors.forename: M
authors.initials: M
authors.lastname: Lakehal
authors.forename: K H
authors.initials: KH
authors.lastname: Tay
authors.forename: Y
authors.initials: Y
authors.lastname: Malledant
authors.forename: B
authors.initials: B
authors.lastname: Launois
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000601:surgery*; D002761:Cholangitis / Q000209:etiology; D005260:Female; D006498:Hepatectomy; D017052:Hospital Mortality; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications