[The beta-hCG subunit, CA 125 and CA 19-9 antigen in the women with non-trophoblastic malignancy of genital tract].
OBJECTIVE
The aim of this study was preoperative estimation of serum level glicoprotein--CA 125, CA 19-9 and beta-hCG in ovarian tumors and comparison obtained values in groups divided according to postoperative pathologic examination.


METHODS
In every patients with ovarian tumors before surgery the level above mentioned antigens was evaluated and compared in following groups: malignant, non-malignant and controls. In control group cut-off values was estimated.


RESULTS
The levels of all investigated glycoproteins were significantly higher in malignant group comparing to benign and controls. The test differentiating non-malignant from malignant tumors was accepted as positive if at least one from markers level was elevated. Specificity of the test was 70%, sensitivity--94%, positive prognostic value--74%, negative prognostic value--94%. In the selected subgroups from non-malignant tumors the serum level of all glycoproteins was surprisingly high.


CONCLUSIONS
Preoperative estimation of CA 125, CA 19-9 and beta-hCG subunit in ovarian tumors permits--at negative result--with probability 93% to qualify tumor as non-malignant and sensitivity of test is 94%.
Piela
A
A
Oddział Ginekologii i Połoznictwa Samodzielnego Publicznego Zespołu Opieki Zdrowotnej w Kolbuszowej.
Lewandowska
M
M
D000328:Adult; D018394:CA-125 Antigen / Q000097:blood* / Q000276:immunology; D018395:CA-19-9 Antigen / Q000097:blood* / Q000276:immunology; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood* / Q000276:immunology; D011379:Prognosis; D012680:Sensitivity and Specificity; D014328:Trophoblastic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000276:immunology
D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D018997:Chorionic Gonadotropin, beta Subunit, Human