title: Development of a time-cycled volume-controlled pressure-limited respirator and lung mechanics system for total liquid ventilation.
abstract: Total liquid ventilation can support gas exchange in animal models of lung injury. Clinical application awaits further technical improvements and performance verification. Our aim was to develop a liquid ventilator, able to deliver accurate tidal volumes, and a computerized system for measuring lung mechanics. The computer-assisted, piston-driven respirator controlled ventilatory parameters that were displayed and modified on a real-time basis. Pressure and temperature transducers along with a lineal displacement controller provided the necessary signals to calculate lung mechanics. Ten newborn lambs (<6 days old) with respiratory failure induced by lung lavage, were monitored using the system. Electromechanical, hydraulic, and data acquisition/analysis components of the ventilator were developed and tested in animals with respiratory failure. All pulmonary signals were collected synchronized in time, displayed in real-time, and archived on digital media. The total mean error (due to transducers, analog-to-digital conversion, amplifiers, etc.) was less than 5% compared with calibrated signals. Components (tubing, pistons, etc.) in contact with exchange fluids were developed so that they could be readily switched, a feature that will be important in clinical settings. Improvements in gas exchange and lung mechanics were observed during liquid ventilation, without impairment of cardiovascular profiles. The total liquid ventilator maintained accurate control of tidal volumes and the sequencing of inspiration/expiration. The computerized system demonstrated its ability to monitor in vivo lung mechanics, providing valuable data for early decision making.
authors.affiliation: Department of Navigation Sciences, Engineers and Shipbuilders, High Technical School of Maritime Studies, Maria Diaz de Haro, Bizkaia, Spain. cnplabaj@lg.ehu.es
authors.forename: J L
authors.initials: JL
authors.lastname: Larrabe
authors.forename: F J
authors.initials: FJ
authors.lastname: Alvarez
authors.forename: E G
authors.initials: EG
authors.lastname: Cuesta
authors.forename: A
authors.initials: A
authors.lastname: Valls-i-Soler
authors.forename: L F
authors.initials: LF
authors.lastname: Alfonso
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz
authors.forename: M B
authors.initials: MB
authors.lastname: Fernández
authors.forename: B
authors.initials: B
authors.lastname: Loureiro
authors.forename: N G
authors.initials: NG
authors.lastname: Publicover
authors.forename: L
authors.initials: L
authors.lastname: Roman
authors.forename: J A
authors.initials: JA
authors.lastname: Casla
authors.forename: M A
authors.initials: MA
authors.lastname: Gómez
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D002138:Calibration; D004867:Equipment Design; D005466:Fluorocarbons / Q000627:therapeutic use; D016014:Linear Models; D021061:Liquid Ventilation / Q000295:instrumentation*; D011659:Pulmonary Gas Exchange; D012756:Sheep; D012815:Signal Processing, Computer-Assisted
chemical_list: D005466:Fluorocarbons