title: Airway compromise secondary to lingual hematoma complicating administration of tissue plasminogen activator for acute ischemic stroke.
abstract: Hemorrhagic complications of tissue plasminogen activator (tPA) are well known. We report a case of a lingual hematoma that developed after tPA administration for an acute ischemic stroke that necessitated orotracheal intubation to maintain the patient's airway. This case demonstrates the need for thorough preadministration physical examination, as well as careful monitoring during infusion and after administration of this potent therapeutic agent.
authors.affiliation: Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY 11030, USA. hshaps@pol.net
authors.forename: H J
authors.initials: HJ
authors.lastname: Shaps
authors.forename: G E
authors.initials: GE
authors.lastname: Snyder
authors.forename: A E
authors.initials: AE
authors.lastname: Sama
authors.forename: G S
authors.initials: GS
authors.lastname: Rudolph
mesh_terms: D000368:Aged; D000402:Airway Obstruction / Q000209:etiology* / Q000628:therapy; D002545:Brain Ischemia; D005260:Female; D005500:Follow-Up Studies; D006406:Hematoma / Q000139:chemically induced* / Q000150:complications; D006801:Humans; D007442:Intubation, Intratracheal; D012121:Respiration, Artificial; D018570:Risk Assessment; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects* / Q000627:therapeutic use; D014060:Tongue Diseases / Q000139:chemically induced* / Q000150:complications
chemical_list: D010959:Tissue Plasminogen Activator