Creatinine-kinase-MB determination in non-cardiac trauma: its difference with cardiac infarction and its restricted use in trauma situations.
Cardiac injuries can be life threatening. The possibility of late complications urges the practitioner to search for any evidence of cardiac trauma. But the diagnosis of cardiac injury remains difficult. Electrocardiography and cardiac enzyme determination are most widely used, because they are readily available. Many studies advocate creatine-kinase-MB (CK-MB) isoenzyme levels as a sensitive test for cardiac contusion. Others have discarded CK-MB testing as useless in trauma situations. An elevated CK-MB value in haemodynamically stable patients may confuse the individual practitioner. To better clarify its role we investigated the course of CK/CK-MB release after trauma, with no or only a very small chance of cardiac injury and compared it with patients with severe chest trauma having cardiac complications. A total of 25 trauma patients with only skeletal muscle injury were studied. Blood samples were taken during the first 4 days after trauma. These results were compared with those of a group of 91 consecutive patients with severe chest injury, including 10 with cardiac complications. Initial results in skeletal trauma patients were indicative of cardiac injury (CK > 5% of total CK and at least 20 U/l) in 10 patients. These findings were identical to those found in patients with severe chest injury having cardiac complications. CK/CK-MB tests are frequently positive after trauma without cardiac injury, even when selective criteria are used. The time each isoenzyme is released from muscle tissue after trauma greatly influences the outcome of the test. As this release does not occur at the same moment for each isoenzyme, the test result is very much time-dependent. As a result of these findings CK-MB testing tends to cause more confusion than clarification in trauma situations. We therefore eliminated CK-MB testing from our trauma protocol as a screening investigation for cardiac injury.
Ruppert
M
M
Academic Surgical Centre Stuivenberg, General Centre Hospital Antwerp, University of Antwerp--UIA, Belgium.
Van Hee
R
R
D000328:Adult; D003402:Creatine Kinase / Q000097:blood* / Q000378:metabolism; D052279:Creatine Kinase, MB Form; D006801:Humans; D007527:Isoenzymes / Q000097:blood* / Q000378:metabolism; D046911:Macromolecular Substances; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000293:injuries*; D009203:Myocardial Infarction / Q000201:enzymology*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013898:Thoracic Injuries / Q000201:enzymology; D014947:Wounds and Injuries / Q000201:enzymology*
D007527:Isoenzymes; D046911:Macromolecular Substances; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form