title: Enzymatic glycosylation of lincomycin.
abstract: Lincomycin (1), a glycosidic antibiotic, active against Gram-positive bacteria, was modified enzymatically with the aim of improving its physico-chemical and biological properties. Compound 1 was glycosylated using jack bean alpha-mannosidase to produce 7-O-alpha-D-mannopyranosyl-lincomycin (2).
authors.affiliation: Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague.
authors.forename: L
authors.initials: L
authors.lastname: Weignerová
authors.forename: J
authors.initials: J
authors.lastname: Spizek
authors.forename: L
authors.initials: L
authors.lastname: Najmanová
authors.forename: V
authors.initials: V
authors.lastname: Kren
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001230:Aspergillus / Q000201:enzymology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007887:Fabaceae / Q000201:enzymology; D006031:Glycosylation; D008034:Lincomycin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008358:Mannose / Q000737:chemistry; D008361:Mannosidases / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D043323:alpha-Mannosidase
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D008034:Lincomycin; D008361:Mannosidases; D043323:alpha-Mannosidase; D008358:Mannose