title: Survival, lung clearance, dosimetry and gross pathology of rats exposed to either NpO2 or PuO2 aerosols.
abstract: OBJECTIVE
  To compare survival, lung dosimetry and gross pathology after inhalation exposure of rats to either NpO2 or industrial PuO2 aerosols with similar granulometric parameters. Because the specific alpha activity ratio Pu/Np is about 600, a much more homogeneous lung irradiation was expected for NpO2.
  
  
  METHODS
  Male Sprague Dawley rats were exposed once and their lung burdens were measured by X-ray spectrometry at different times post-exposure up to death. The time-course of doses delivered to the lungs were estimated, taking into account individual lung clearance parameters and body and lung weights. Gross lung pathologies were scored at autopsy.
  
  
  RESULTS
  In the range of initial lung deposits (ILD) studied (0.1-4 kBq), lung clearance impairment and reduced lifespan were only observed after exposure to NpO2. For similar ILD or doses, the highest incidences of lung lesions assumed to be tumours were observed for NpO2 with a saturation of lung tumour induction for doses larger than 8 Gy (ILD: 1.5kBq). Up to 22Gy (ILD: 3.5kBq), such saturation was not observed for PuO2.
  
  
  CONCLUSIONS
  NpO2 appears much more toxic than PuO2. Before saturation, lung tumour incidence increased nearly linearly with dose, the slope of the curve for NpO2 being about twice as steep as that for PuO2.
authors.affiliation: Laboratoire de Radiotoxicologie, CEA/DSV/LRT, BP 12, F-91680 Bruyères-le-Châtel, France.
authors.forename: N
authors.initials: N
authors.lastname: Dudoignon
authors.forename: K
authors.initials: K
authors.lastname: Guillet
authors.forename: G
authors.initials: G
authors.lastname: Rateau
authors.forename: P
authors.initials: P
authors.lastname: Fritsch
mesh_terms: D000336:Aerosols; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D008168:Lung / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D009405:Neptunium / Q000493:pharmacokinetics / Q000633:toxicity*; D009929:Organ Size / Q000528:radiation effects; D011005:Plutonium / Q000493:pharmacokinetics / Q000633:toxicity*; D011829:Radiation Dosage; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000336:Aerosols; C026885:plutonium dioxide; D011005:Plutonium; D009405:Neptunium