title: Inhibitory effect of peptide vilon on the development of induced rat urinary bladder tumors in rats.
abstract: The effect of peptide vilon (Lys-Glu) on urinary bladder carcinogenesis in rats was studied. Urinary bladder tumors were induced with a selective carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. The tumors developed in 56% vilon-treated animals and in 75.5% controls. Vilon 2-fold decreased the incidence of preneoplastic and early neoplastic changes in urinary bladder mucosa and significantly inhibited carcinogenesis.
authors.affiliation: N. N. Petrov Institute of Oncology, Health Ministry of the Russian Federation.
authors.forename: G B
authors.initials: GB
authors.lastname: Pliss
authors.forename: A S
authors.initials: AS
authors.lastname: Mel'nikov
authors.forename: V V
authors.initials: VV
authors.lastname: Malinin
authors.forename: V K
authors.initials: VK
authors.lastname: Khavinson
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity; D004151:Dipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000276:Adjuvants, Immunologic; D002273:Carcinogens; D004151:Dipeptides; D002085:Butylhydroxybutylnitrosamine; C415909:lysylglutamic acid