title: Chest wall metastasis from recurrent meningioma.
abstract: Meningiomas are generally considered benign lesions. A minority, however, are capable of metastasis. The ones most likely to do so are commonly recurrent or frankly malignant in nature. The optimal management of such metastases is unclear. This is the first reported case of meningioma presenting as an isolated metastasis to the chest wall. This case involves a 64-year-old woman without significant medical or family history who underwent resection of a meningioma of the right cerebral hemisphere. She was treated 10 years later for recurrence by stereotactic radiosurgery. Three years after that, the patient's family noticed a mass on the left chest wall. A CT scan revealed destruction of the ninth rib laterally and subpleural extension. The patient subsequently underwent resection of full-thickness chest wall for a presumed soft-tissue sarcoma. Further pathologic evaluation including electron microscopy and immunohistochemistry revealed metastatic meningioma. The patient received adjuvant radiation to the chest wall and is currently free of disease at the chest wall one year after surgery. This case illustrates the difficulty in establishing an accurate diagnosis of metastatic meningioma. Consequently in selected patients with a history of the disease the diagnosis of metastatic meningioma must at least be considered. Resection of an isolated metastasis in this setting appears warranted.
authors.affiliation: Department of General Surgery, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Williamson
authors.forename: C A
authors.initials: CA
authors.lastname: Stanton
authors.forename: E A
authors.initials: EA
authors.lastname: Levine
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary* / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008579:Meningioma / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012272:Ribs; D012983:Soft Tissue Neoplasms / Q000556:secondary* / Q000601:surgery; D013909:Thorax