The role of cytokine polymorphisms in rejection after solid organ transplantation.
The importance of cytokines to the immune response is irrefutable. Their role in the biology of solid organ transplantation per se is also assured. Thus it is likely that subtle differences in cytokine composition, particularly at the initiation of an immune response, may have a major effect on the outcome of that response. This may be particularly relevant in solid organ transplantation, where it is possible that genetic polymorphisms which influence cytokine production may determine the outcome of a transplant. Indeed, it has been suggested that immunosuppression may be individualised on the basis of recipient or donor genotype. However, much of the early data regarding the importance of specific cytokine polymorphisms has not been reproduced, and the significance of this field remains controversial. Nonetheless, with the experience gained from earlier studies, some clear patterns for future studies are emerging.
Marshall
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Oxford Transplant Centre, Churchill Hospital, Oxford OX3 7LJ, UK.
Welsh
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D016207:Cytokines / Q000235:genetics* / Q000276:immunology*; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D007372:Interferons / Q000235:genetics; D007378:Interleukins / Q000235:genetics; D008233:Lymphotoxin-alpha / Q000235:genetics; D016377:Organ Transplantation; D011110:Polymorphism, Genetic / Q000235:genetics*; D014019:Tissue Donors; D014180:Transplantation; D023001:Transplantation Tolerance / Q000235:genetics / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D016207:Cytokines; D007378:Interleukins; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons