Fhit protein expression in human gastric cancer and related precancerous lesions.
The FHIT gene is altered in several types of tumors and abnormal expression of Fhit protein have also been reported in some preneoplastic lesions. We have determined the Fhit expression on histological samples of 26 patients affected by preneoplastic lesions who developed a gastric cancer within 2 years. The expression of the Fhit protein was always present in all preneoplastic lesions, while the Fhit protein immunostaining was distributed unevenly in 10 cases and completely lost in 6. The complete loss of Fhit expression only in areas of neoplastic low differentiation suggests that FHIT gene takes part in late gastric carcinogenesis.
Caselli
M
M
Institute of Internal Medicine I, University of Ferrara, Ferrara, Italy.
Marchisio
M
M
Gaudio
M
M
Saragoni
L
L
Lanza
G
G
Alvisi
V
V
Bertagnolo
V
V
Concu
M
M
Capitani
S
S
Caramelli
E
E
D017766:Acid Anhydride Hydrolases; D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016481:Helicobacter Infections / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D011230:Precancerous Conditions / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase