title: [Chemical constituents of Phyllanthus urinaria L. and its antiviral activity against hepatitis B virus].
abstract: Studies on the chemical constituents of Phyllanthus urinaria and its antiviral activity against hepatitis B virus were completed. Eleven compounds have been isolated. Two of them are new compounds methyl ester dehydrochebulic acid and methyl brevifolin carboxylate. Antiviral experiments on HBsAg in vitro and liver damage caused by CCl4 have shown that. Phyllanthus urinaria possesses antiviral activities against HBV.
authors.affiliation: Institute of Meteria Medica, Shangdong Academy of Medical Sciences, Jinan 250062.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhong
authors.forename: C
authors.initials: C
authors.lastname: Zuo
authors.forename: F
authors.initials: F
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Ding
authors.forename: Q
authors.initials: Q
authors.lastname: Yao
authors.forename: K
authors.initials: K
authors.lastname: Wu
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: L W
authors.initials: LW
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Lan
authors.forename: X
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D006509:Hepatitis B / Q000188:drug therapy; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D008298:Maleates / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D000998:Antiviral Agents; D001578:Benzopyrans; D004365:Drugs, Chinese Herbal; D008298:Maleates; C087786:methyl brevifolincarboxylate; C087785:dehydrochebulic acid trimethyl ester