[Connection of HindIII-polymorphism in the lipoprotein lipase gene with myocardial infarct and life span in elderly ischemic heart disease patients].
Allele and genotype frequencies of the HindIII polymorphism of the lipoprotein lipase (LPL) gene were studied in patients with myocardial infarction (MI) and stable angina of effort (SAE), including long-lived people (over 90). The polymorphism proved to be associated with MI and with the life span, genotype H+/H+ being predisposing to MI and allele H- being protective. The allele and genotype frequencies of long-lived people differed significantly from the Hardy-Weinberg proportions and from those of SAE patients aged up to 90. An excess of heterozygotes in this group suggests a selective pressure which eliminates homozygotes. Possibly, heterozygotes H+/H- have an adaptive advantage, which provides for their longevity.
Malygina
N A
NA
derjagin@ium.ips.ras.ru
Melent'ev
A S
AS
Kostomarova
I V
IV
Melent'ev
I A
IA
Saégitov
R T
RT
Smirnova
Iu B
IuB
Serova
L D
LD
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D005838:Genotype; D006801:Humans; D008017:Life Expectancy; D008071:Lipoprotein Lipase / Q000235:genetics*; D009203:Myocardial Infarction / Q000201:enzymology / Q000235:genetics*; D017202:Myocardial Ischemia / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000235:genetics*
D017931:DNA Primers; C090528:DNA modification methylase HindIII; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific); D008071:Lipoprotein Lipase
Sviaz' HindIII-polimorfizma v gene lipoproteinlipazy s infarktom miokarda i prodolzhitel'nost'iu zhizni u bol'nykh ishemicheskoé bolzn'iu serdtsa pozhilogo i starcheskogo vozrasta.