title: Elevated substance P levels in HIV-infected men.
abstract: The neuropeptide, substance P, is a potent modulator of neuroimmunoregulation. Substance P and its receptor modulate HIV infection. HIV-seropositive men had significantly higher plasma substance P levels compared with uninfected controls, which were associated with decreased CD16 and CD56 natural killer (NK) cell populations. The changes in plasma substance P levels and decreases in NK subsets did not correlate with CD4 cell levels, but a diurnal pattern was suggested for substance P. The balance between substance P expression and functions of immune cells may be important in the immunopathogenesis of HIV infection.
authors.affiliation: Section of Immunology, Division of Immunologic and Infectious Diseases, The Joseph Stokes Jr Research Institute, The Children's Hospital of Philadelphia, PA, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Douglas
authors.forename: W Z
authors.initials: WZ
authors.lastname: Ho
authors.forename: D R
authors.initials: DR
authors.lastname: Gettes
authors.forename: A
authors.initials: A
authors.lastname: Cnaan
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Leserman
authors.forename: J M
authors.initials: JM
authors.lastname: Petitto
authors.forename: R N
authors.initials: RN
authors.lastname: Golden
authors.forename: D L
authors.initials: DL
authors.lastname: Evans
mesh_terms: D015331:Cohort Studies; D005434:Flow Cytometry; D015658:HIV Infections / Q000097:blood* / Q000276:immunology; D018023:HIV Seronegativity; D006716:Homosexuality; D006801:Humans; D007694:Killer Cells, Natural; D008297:Male; D013373:Substance P / Q000097:blood*
chemical_list: D013373:Substance P