title: Corticotroph cell adenoma without typical manifestations of Cushing's disease presenting with cavernous sinus syndrome following pituitary apoplexy.
abstract: This report presents a unique case of corticotroph cell adenoma in a 30-year-old man without acromegaly or features typical of Cushing's disease, who developed cavernous sinus syndrome following pituitary apoplexy. Magnetic resonance imaging revealed a large intrasellar/suprasellar mass with pituitary hemorrhage and extension of a hematoma to the anterior base of the skull. Urgent transnasal pituitary surgery revealed an acidophilic pituitary adenoma, with immunoreactivity for ACTH and GH and expression of proopiomelanocortin (POMC) and GH messenger ribonucleic acid (mRNA) demonstrated by in situ hybridization. To our knowledge, a silent corticotroph cell adenoma with GH production has never been reported. This type of adenoma may potentially enlarge and develop tumoral hemorrhage because it is free of endocrinological symptoms.
authors.affiliation: Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Sawabe
authors.forename: Y
authors.initials: Y
authors.lastname: Mochizuki
authors.forename: S
authors.initials: S
authors.lastname: Sunaga
authors.forename: H
authors.initials: H
authors.lastname: Izumiyama
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Kushima
authors.forename: M
authors.initials: M
authors.lastname: Taniyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ban
authors.forename: T
authors.initials: T
authors.lastname: Sano
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000032:analysis* / Q000097:blood; D000328:Adult; D002426:Cavernous Sinus / Q000473:pathology*; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis; D019382:Human Growth Hormone / Q000032:analysis / Q000235:genetics; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D010899:Pituitary Apoplexy / Q000150:complications* / Q000473:pathology; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D011333:Pro-Opiomelanocortin / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D013577:Syndrome; D014057:Tomography, X-Ray Computed
chemical_list: D012333:RNA, Messenger; D019382:Human Growth Hormone; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone