title: Cytogenetic findings in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical course.
abstract: We correlated bone marrow cytogenetic findings with morphologic and immunophenotypic data in 37 patients with lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM). Each LPL/WM case was classified as lymphoplasmacytoid (n = 18), lymphoplasmacytic (n = 10), or polymorphous (n = 9) using the Kiel criteria. Of 12 cases with chromosomal abnormalities, a single numeric abnormality was present in 4 and a complex karyotype in 8. The most common numeric abnormalities were and -8 in 3 cases each; the most common structural abnormality was del(6q) in 6 cases. Cytogenetic abnormalities were significantly less common in the lymphoplasmacytic and lymphoplasmacytoid groups (5/28 [18%]) compared with the polymorphous group (7/9 [78%]). Clinical follow-up was available for 28 patients for a median of 36 months. Six (67%) of 9 patients with aneuploid tumors, including 4 with polymorphous subtype, subsequently had clinical progression or developed high-grade lymphoma. In contrast, 4 (21%) of 19 patients with diploid tumors, including 1 of polymorphous type, developed clinical progression or high-grade lymphoma. We conclude that abnormal cytogenetic findings in LPL/WM correlate with the polymorphous subtype and poor prognosis.
authors.affiliation: Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Mansoor
authors.forename: L J
authors.initials: LJ
authors.lastname: Medeiros
authors.forename: D M
authors.initials: DM
authors.lastname: Weber
authors.forename: R
authors.initials: R
authors.lastname: Alexanian
authors.forename: K
authors.initials: K
authors.lastname: Hayes
authors.forename: D
authors.initials: D
authors.lastname: Jones
authors.forename: R
authors.initials: R
authors.lastname: Lai
authors.forename: A
authors.initials: A
authors.lastname: Glassman
authors.forename: C E
authors.initials: CE
authors.lastname: Bueso-Ramos
mesh_terms: D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000276:immunology / Q000473:pathology; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D020732:Cytogenetic Analysis; D005260:Female; D017353:Gene Deletion; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D014314:Trisomy; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics* / Q000473:pathology; D014998:Y Chromosome