Mechanisms of platelet aggregation.
Platelet aggregation is initiated by receptor activation coupled to intracellular signaling leading to activation of integrin alphaIIbbeta3. Recent advances in the study of platelet receptors for collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new insights into the mechanisms of platelet aggregation.
Savage
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The Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.
Cattaneo
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Ruggeri
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ZM
D000818:Animals; D016023:Integrins / Q000502:physiology; D008954:Models, Biological; D010974:Platelet Aggregation; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000502:physiology; D038981:Receptors, Collagen; D018048:Receptors, Purinergic P2 / Q000502:physiology; D018179:Receptors, Thrombin / Q000502:physiology; D015398:Signal Transduction; D013917:Thrombin / Q000502:physiology
D016023:Integrins; D019038:Platelet Glycoprotein GPIb-IX Complex; D038981:Receptors, Collagen; D018048:Receptors, Purinergic P2; D018179:Receptors, Thrombin; D013917:Thrombin