Probucol decreases total body fat loss in VX2-carcinoma-induced cachectic rabbits.
We previously reported the continuous decrease of total body fat in VX2-carcinoma-bearing rabbits after tumor implantation, as well as changes in the serum lipid profile. Probucol, an antioxidant drug, has a cholesterol lowering effect against hyperlipidemic subjects. VX2-carcinoma-bearing rabbits fed with a diet containing 1% probucol did not show any difference in serum lipid compositions as compared with rabbits fed with a control diet. Similarly serum lipolytic activity showed no differences, whether probucol was administered or not, while the decrease in total body fat was significantly less when probucol was administered.
Hyun
Y
Y
Department of Obstetrics and Gynecology, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan.
Ishiko
O
O
Honda
K
K
Hirai
K
K
Sumi
T
T
Hattori
K
K
Nakagawa
E
E
Yasui
T
T
Nishimura
S
S
Ogita
S
S
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002100:Cachexia / Q000209:etiology* / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000503:physiopathology*; D011341:Probucol / Q000494:pharmacology*; D011817:Rabbits
D000924:Anticholesteremic Agents; D000975:Antioxidants; D008055:Lipids; D011341:Probucol