title: Neurobehavioral status and health-related quality of life in newly diagnosed high-grade glioma patients.
abstract: OBJECTIVE
  To evaluate the health-related quality of life (HRQOL) and cognitive functioning of high-grade glioma patients in the postneurosurgical period.
  
  
  METHODS
  The HRQOL, as assessed by the Short-Form Health Survey-36, tumor-specific symptoms, and objective and subjective neuropsychologic functioning, of 68 newly diagnosed glioma patients were compared with that of 50 patients with non-small-cell lung cancer (NSCLC) and to age- and sex-matched healthy controls. The association between tumor lateralization, extent of resection, and use of medication, and the HRQOL outcomes was also investigated.
  
  
  RESULTS
  The HRQOL of the two patient groups was similar but significantly lower than that of the healthy controls. Glioma patients reported significantly more neurologic symptoms and poorer objective and subjective neuropsychologic functioning than the NSCLC patients. Using healthy controls as the reference group, cognitive impairment assessed at the individual patient level was observed in all glioma patients and 52% of the NSCLC patients. Poor performance on timed tasks in the glioma group could be attributed, in large part, to visual and motor deficits. Tumor lateralization was found to affect neuropsychologic functioning in a predictable manner. The extent of resection was not related significantly to neuropsychologic functioning. Corticosteroid use was associated with better recognition memory, whereas antiepileptic drug use was correlated negatively with working memory capacity.
  
  
  CONCLUSIONS
  The general HRQOL of glioma patients is similar to that of patients with NSCLC. However, they suffer from a number of condition-specific neurologic and neuropsychologic problems that have a significant impact on their daily lives in the postsurgical period, before treatment with radiotherapy.
authors.affiliation: Department of Medical Psychology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. m.klein.psychol@med.vu.nl
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: M J
authors.initials: MJ
authors.lastname: Taphoorn
authors.forename: J J
authors.initials: JJ
authors.lastname: Heimans
authors.forename: H M
authors.initials: HM
authors.lastname: van der Ploeg
authors.forename: W P
authors.initials: WP
authors.lastname: Vandertop
authors.forename: E F
authors.initials: EF
authors.lastname: Smit
authors.forename: S
authors.initials: S
authors.lastname: Leenstra
authors.forename: C A
authors.initials: CA
authors.lastname: Tulleken
authors.forename: W
authors.initials: W
authors.lastname: Boogerd
authors.forename: J S
authors.initials: JS
authors.lastname: Belderbos
authors.forename: W
authors.initials: W
authors.lastname: Cleijne
authors.forename: N K
authors.initials: NK
authors.lastname: Aaronson
mesh_terms: D001288:Attention; D002289:Carcinoma, Non-Small-Cell Lung / Q000503:physiopathology; D016543:Central Nervous System Neoplasms / Q000503:physiopathology* / Q000523:psychology; D003071:Cognition; D005260:Female; D005910:Glioma / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D017567:Karnofsky Performance Status; D008175:Lung Neoplasms / Q000503:physiopathology; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D010465:Perception; D011788:Quality of Life