The methanol hemisolvate of amiloride hydrochloride.
In the asymmetric unit of N-(3,5-diamino-6-chloropyrazin-2-ylcarbonyl)-N-(diaminomethylene)ammonium chloride methanol hemisolvate, C(6)H(9)ClN(7)O(+).Cl(-).0.5CH(4)O, there are two crystallographically different amiloride molecules. Crystallographically identical amiloride molecules are stacked one above the other, alternately rotated by 180 degrees. These stacks are arranged parallel to each other, forming layer A. The least-squares plane of the non-H atoms of the other molecules lying in layer B is tilted against the corresponding plane of the molecules in layer A by an angle of 79.89 (3) degrees. The methanol molecules and Cl(-) anions are located between these layers, although the methanol molecules are closer to layer A.
Pretscher
A
A
Department of Pharmaceutics, University of Tromsø, N-9037 Tromsø, Norway. andreap@farmasi.uit.no
Brisander
M
M
Bauer-Brandl
A
A
Hansen
L K
LK
D000584:Amiloride / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004232:Diuretics / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular
D004232:Diuretics; D000584:Amiloride