Drug resistance in Trypanosoma cruzi is not associated with amplification or overexpression of P-glycoprotein (PGP) genes.
Murta
S M
SM
Laboratório de Parasitologia Celular e Molecular, Centro de Pesquisas René Rachou, FIOCRUZ, Av. Augusto de Lima 1715, Caixa Postal 1743, CEP 30190-002, Belo Horizonte, MG, Brazil.
dos Santos
W G
WG
Anacleto
C
C
Nirdé
P
P
Moreira
E S
ES
Romanha
A J
AJ
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics* / Q000378:metabolism*; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D000818:Animals; D014355:Chagas Disease / Q000469:parasitology; D004351:Drug Resistance; D005784:Gene Amplification; D006023:Glycoproteins; D006801:Humans; D007621:Karyotyping; D051379:Mice; D009547:Nifurtimox / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D012150:Polymorphism, Restriction Fragment Length; D015800:Protozoan Proteins; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
D018435:ATP Binding Cassette Transporter, Subfamily B; D018528:ATP-Binding Cassette Transporters; D006023:Glycoproteins; D009593:Nitroimidazoles; D015800:Protozoan Proteins; C404509:Tcpgp1 protein, Trypanosoma cruzi; C102792:Tcpgp2 protein, Trypanosoma cruzi; D014344:Trypanocidal Agents; D009547:Nifurtimox; C009999:benzonidazole