title: Infected joint replacements in HIV-positive patients with haemophilia.
abstract: Joint replacement in HIV-positive patients remains uncommon, with most experience gained in patients with haemophilia. We analysed retrospectively the outcome of 102 replacement arthroplasties in 73 HIV-positive patients from eight specialist haemophilia centres. Of these, 91 were primary procedures. The mean age of the patients at surgery was 39 years, and the median follow-up was for five years. The overall rate of deep sepsis was 18.7% for primary procedures and 36.3% for revisions. This is a much higher rate of infection than that seen in normal populations. A total of 44% of infections resolved fully after medical and/or surgical treatment. The benefits of arthroplasty in haemophilic patients are well established but the rates of complications are high. As this large study has demonstrated, high rates of infection occur, but survivorship analysis strongly suggests that most patients already diagnosed with HIV infection at the time of surgery should derive many years of symptomatic relief after a successful joint replacement. Careful counselling and education of both patients and healthcare workers before operation are therefore essential.
authors.affiliation: Northampton General Hospital NHS Trust, Cliftonville, England.
authors.forename: J L
authors.initials: JL
authors.lastname: Hicks
authors.forename: W J
authors.initials: WJ
authors.lastname: Ribbans
authors.forename: B
authors.initials: B
authors.lastname: Buzzard
authors.forename: S S
authors.initials: SS
authors.lastname: Kelley
authors.forename: L
authors.initials: L
authors.lastname: Toft
authors.forename: G
authors.initials: G
authors.lastname: Torri
authors.forename: J D
authors.initials: JD
authors.lastname: Wiedel
authors.forename: J
authors.initials: J
authors.lastname: York
mesh_terms: D000328:Adult; D006679:HIV Seropositivity / Q000150:complications* / Q000401:mortality; D006467:Hemophilia A / Q000150:complications* / Q000401:mortality; D006801:Humans; D007595:Joint Prosthesis / Q000009:adverse effects*; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate