Deamidation of human proteins.
Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.
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Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. noahr@its.caltech.edu
Robinson
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D001216:Asparagine / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*
D011506:Proteins; D005973:Glutamine; D001216:Asparagine