[Role of local immunity in invasive pulmonary aspergillosis].
A LEADING CAUSE OF MORTALITY: Inhalation of fungal spores may cause infection and/or inflammation, which is dependent on the nature of the fungus as well as the individual's immune status. Aspergillus fumigatus is responsible for a dramatic pathology, invasive aspergillosis (IA). IA has become a leading cause of death, mainly among bone marrow transplantation or solid-organ recipients, but also among AIDS patients. IMMUNE RESPONSE: The diversity of immune failure suggests that many lines of immunity are implicated in the A. fumigatus elimination process. Non specific immunity plays a major role in the defence against A. fumigatus, including three major lines: anatomical barriers, humoral components, phagocytic cells. But acquired immunity plays a role with different T-cell subsets and their associated cytokines. FUNGUS-HOST RELATIONSHIPS: The relationship between the fungus and its host is complex and could be again study to improve the prevention and the treatment of IA. The aim of this review is a synthesis of the knowledge about the immunity response against Aspergillus fumigatus in IA.
Aldebert
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D
Laboratoire Interactions cellulaires Parasites-Hôte EA-2940, Faculté de Médecine-Pharmacie, Université Joseph Fourier, Grenoble I, La Tronche. Delphine.Aldebert@ujf-grenoble.fr
Pinel
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C
Brion
J P
JP
Ambroise-Thomas
P
P
Grillot
R
R
D001228:Aspergillosis / Q000276:immunology*; D001232:Aspergillus fumigatus / Q000276:immunology*; D018925:Chemokines / Q000097:blood; D016207:Cytokines / Q000097:blood; D006801:Humans; D008172:Lung Diseases, Fungal / Q000276:immunology*; D009894:Opportunistic Infections / Q000175:diagnosis / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology
D018925:Chemokines; D016207:Cytokines
Le rôle de l'immunité locale dans l'aspergillose pulmonaire invasive.