title: Probucol decreases total body fat loss in VX2-carcinoma-induced cachectic rabbits.
abstract: We previously reported the continuous decrease of total body fat in VX2-carcinoma-bearing rabbits after tumor implantation, as well as changes in the serum lipid profile. Probucol, an antioxidant drug, has a cholesterol lowering effect against hyperlipidemic subjects. VX2-carcinoma-bearing rabbits fed with a diet containing 1% probucol did not show any difference in serum lipid compositions as compared with rabbits fed with a control diet. Similarly serum lipolytic activity showed no differences, whether probucol was administered or not, while the decrease in total body fat was significantly less when probucol was administered.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hyun
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Sumi
authors.forename: K
authors.initials: K
authors.lastname: Hattori
authors.forename: E
authors.initials: E
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Yasui
authors.forename: S
authors.initials: S
authors.lastname: Nishimura
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002100:Cachexia / Q000209:etiology* / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000503:physiopathology*; D011341:Probucol / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D008055:Lipids; D011341:Probucol