title: [Influenza vaccination of human immunodeficiency virus-infected patients with severe immunodepression. Impact on CD4 lymphocytes and plasma viral load].
abstract: BACKGROUND
  The aim of this study was to assess the effect of influenza vaccination on plasma HIV viral load and CD4 T-lymphocytes in patients with advanced HIV disease.
  
  
  METHODS
  Observational study carried out in HIV-infected patients with a CD4 cell count < 200 X 10(6)on highly active antiretroviral therapy(HAART). Influenza vaccine was voluntarily offered and plasma viral load and CD4 cell counts were measured at baseline, 4 weeks and 12 weeks in vaccinated and control subjects.
  
  
  RESULTS
  Sixteen patients were analysed, 10 of them being immunized with the influenza vaccine. A significant decline in CD4 cell counts at 4 and 12 weeks and an increasing trend of viral load were seen in all immunized patients who had a high viral load at the time of vaccination (n = 6), but not in those with an undetectable viral load. The mean decrease of CD4 T-lymphocytes in these 6 patients was 49.8%. Three patients showed a huge drop of the CD4 cell count (over 60% of baseline).
  
  
  CONCLUSIONS
  Influenza vaccination of severely immunocompromised HIV-infected patients who are failing to HAART might be associated with an immunological impairment.
authors.affiliation: Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital General Universitario de Elche, Alicante, Spain. guitierrez_fel@gva.es
authors.forename: F
authors.initials: F
authors.lastname: Gutiérrez
authors.forename: A
authors.initials: A
authors.lastname: Maestre
authors.forename: J
authors.initials: J
authors.lastname: Manuel Ramos
authors.forename: M
authors.initials: M
authors.lastname: Masiá
authors.forename: C
authors.initials: C
authors.lastname: Escolano
authors.forename: A M
authors.initials: AM
authors.lastname: Hidalgo
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000276:immunology / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D007252:Influenza Vaccines; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D019562:Viral Load
chemical_list: D007252:Influenza Vaccines
vernacular_title: Vacuna antigripal en pacientes infectados por el virus de la inmunodeficiencia humana con inmunodepresión grave. Efecto sobre los linfocitos CD4 y sobre la carga viral plasmática.