[Sera levels of anti-Trypanosoma cruzi IgG in the course of chronic chagasic cardiopathy in 10 years].
In order to investigate the relationship between T. cruzi specific antibodies (IgG) levels and the clinical course of chronic chagasic cardiopathy, the authors analyzed sera from 140 non-treated patients with specific drugs from Virgem da Lapa, Minas Gerais, during 10 years. Of these patients, 92 were women and 48 men, varying from 10 to 70 years old (mean = 38 +/-13.5 years). Antibody levels were estimated by the mean of titers obtained by an indirect immunofluorescence test, indirect hemagglutination assay and by the mean reactivity indexes (OD/cut-off) obtained by ELISA tests using a conventional antigens and recombinant proteins (CRA+FRA). During the study period, the course of the disease was as follows: 49 did not present cardiac alterations, 29 coursed to cardiopathy, 33 maintained initial cardiopathy, 25 evolved with aggravation of the cardiopathy and 4 with normalization of the electrocardiogram. Statistical analysis showed a significant increase in antibody levels among patients in the group with progressive cardiopathy, as well as in patients with age interval of 20 to 59 years, independent of sex. These findings indicated a direct association between T. cruzi specific antibodies (IgG) levels and the clinical course of chronic chagasic cardiopathy.
Zauza
P L
PL
Departamento de Medicina Tropical, Instituto Oswaldo Cruz, Fundação Osvaldo Cruz, Rio de Janeiro, RJ, Brasil.
Borges-Pereira
J
J
D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D002598:Chagas Cardiomyopathy / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014349:Trypanosoma cruzi / Q000276:immunology*
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G
Níveis séricos de IgG anti-Trypanosoma cruzi na evolução da cardiopatia chagásica crônica, no período de 10 anos.