Is dimerization of chemokine receptors functionally relevant?
Chemokines activate lymphocytes by initiating signaling cascades through cell surface receptors that couple to heterotrimeric GTP-binding proteins. Thelen and Bagglioni describe why the recent proposal that these receptors form heterodimers and activate the Jak kinases for transducing signals should be viewed with caution.
Thelen
M
M
Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland. marcus.thelen@irb.unisi.ch
Baggiolini
M
M
D000818:Animals; D018932:Chemokine CCL2 / Q000502:physiology; D018946:Chemokine CCL5 / Q000502:physiology; D019281:Dimerization; D053613:Janus Kinase 1; D007962:Leukocytes / Q000378:metabolism; D008954:Models, Biological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000378:metabolism / Q000502:physiology; D019707:Receptors, Chemokine / Q000378:metabolism* / Q000502:physiology*; D015398:Signal Transduction
D018932:Chemokine CCL2; D018946:Chemokine CCL5; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine; D011505:Protein-Tyrosine Kinases; D053613:Janus Kinase 1