title: Synthesis and antimycobacterial activity of 5-aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4, 5-dihydro-1H-pyrazole derivatives.
abstract: 5-Aryl-1-isonicotinoyl-3-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. The compounds showed an interesting activity against a strain of Mycobacterium tuberculosis and a human strain of M. tuberculosis H4.
authors.affiliation: Dipartimnento di Scienze Farmaceutiche, Università di Trieste, Italy. mamolo@univ.trieste.it
authors.forename: M G
authors.initials: MG
authors.lastname: Mamolo
authors.forename: D
authors.initials: D
authors.lastname: Zampieri
authors.forename: V
authors.initials: V
authors.lastname: Falagiani
authors.forename: L
authors.initials: L
authors.lastname: Vio
authors.forename: E
authors.initials: E
authors.lastname: Banfi
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D011720:Pyrazoles