title: Translocations involving c-myc and c-myc function.
abstract: c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed. The c-myc gene produces an oncogenic transcription factor that affects diverse cellular processes involved in cell growth, cell proliferation, apoptosis and cellular metabolism. Complete removal of c-myc results in slowed cell growth and proliferation, suggesting that while c-myc is not required for cell proliferation, it acts as an integrator and accelerator of cellular metabolism and proliferation.
authors.affiliation: Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, California CA 94305, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Boxer
authors.forename: C V
authors.initials: CV
authors.lastname: Dang
mesh_terms: D050976:Basic-Leucine Zipper Transcription Factors; D002051:Burkitt Lymphoma / Q000235:genetics; D002448:Cell Adhesion; D002454:Cell Differentiation; D002455:Cell Division; D016922:Cellular Senescence; D004268:DNA-Binding Proteins / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc / Q000235:genetics*; D008957:Models, Genetic; D008958:Models, Molecular; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism* / Q000502:physiology*; D014157:Transcription Factors; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D014178:Translocation, Genetic
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C067850:Myc associated factor X; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors