The role of glycoprotein IIb/IIIa inhibition in the management of acute coronary syndromes.
Recent advances in the understanding of the pathophysiology of thrombus formation and the role of platelet adhesion have led to a new pharmacologic era in cardiology. The advent of the glycoprotein IIb/IIIa inhibitor, primarily used in conjunction with percutaneous coronary intervention, has proved to be beneficial beyond the confines of the cardiac catheterization laboratory. The glycoprotein IIb/IIIa inhibitor has inspired much research in the past few years of its use in the management of acute coronary syndromes. The CAPTURE, PURSUIT, PRISM, and PRISM-PLUS trials have all documented the beneficial effects of glycoprotein IIb/IIIa inhibition that have reduced 2 of the major sequelae of acute coronary syndromes: myocardial infarction and death. Through the implementation of primary research-based data, it is the job of practitioners to appropriately stratify and implement judicious use of glycoprotein IIb/IIIa inhibition with the population affected by acute coronary syndromes.
Koller
C F
CF
University of Pennsylvania, Chalfont, USA.
D000077284:Abciximab; D000208:Acute Disease; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy* / Q000209:etiology; D000077542:Eptifibatide; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000009:adverse effects / Q000627:therapeutic use*; D010455:Peptides / Q000009:adverse effects / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D016032:Randomized Controlled Trials as Topic; D000077466:Tirofiban; D014443:Tyrosine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014443:Tyrosine; D000077466:Tirofiban; D000077542:Eptifibatide; D000077284:Abciximab