Retargeting gene delivery using surface-engineered retroviral vector particles.
Retroviral vectors with the capacity to deliver transgenes to specific tissues are expected to be of great value for various gene transfer applications in vivo. Initial attempts to modify vector host-range by the insertion of ligands on their surface glycoproteins have frequently failed, essentially owing to the impairment of the fusogenicity of the vector particles bound to the targeted cell-surface molecules. Several strategies aimed to recover the fusogenic activity of surface-engineered vector particles have recently been explored and have given rise to novel concepts in the field.
Lavillette
D
D
Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, Unité de Virologie Humaine, INSERM U412, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Cedex 07, Lyon, France.
Russell
S J
SJ
Cosset
F L
FL
D000818:Animals; D018390:Gene Targeting / Q000379:methods*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D008561:Membrane Fusion; D008954:Models, Biological; D015202:Protein Engineering / Q000379:methods; D011991:Receptors, Virus / Q000378:metabolism; D012190:Retroviridae / Q000235:genetics*; D013045:Species Specificity; D014760:Viral Fusion Proteins / Q000235:genetics* / Q000502:physiology; D014771:Virion / Q000235:genetics / Q000378:metabolism
D011991:Receptors, Virus; D014760:Viral Fusion Proteins