The impact of ischaemic preconditioning on spinal cord blood flow and paraplegia.
OBJECTIVE
We investigated the effect of ischaemic preconditioning (IP) on ischaemic spinal cord injury in a rabbit model.


METHODS
Fourteen rabbits were divided into IP and control groups of seven rabbits each. We repeated 3-min clamping of the infrarenal abdominal aorta and 3-min reperfusion twice (preconditioning), followed by 15 min clamping in the IP group. In the control group, the aorta was clamped for 15 min without preconditioning. Lumbar cord blood flow and systemic blood pressure were measured until 3 h of reperfusion. Another 14 rabbits underwent the same procedures with or without IP and neurologic status was assessed on the second postoperative day.


RESULTS
The percent change in lumbar cord blood flow after reperfusion was significantly greater (P=0.013) in the IP group despite lower mean blood pressure. There was no significant difference in overall neurologic status (P=0.461) but the incidence of spastic paraplegia in the IP group was lower (14%, 1/7) than that of control group (43%, 3/7).


CONCLUSIONS
IP increased postischaemic lumbar cord blood flow and contributed to lower incidence of spastic paraplegia.
Ueno
T
T
Department of Thoracic and Cardiovascular Surgery, Saga Medical School, 5-1-1 Nabeshima, Saga City, Saga 849-9501, Japan. tueno@uresino.hosp.go.jp
Chao
Z L
ZL
Okazaki
Y
Y
Itoh
T
T
D000818:Animals; D004195:Disease Models, Animal; D019194:Ischemic Preconditioning; D010264:Paraplegia / Q000517:prevention & control*; D011817:Rabbits; D012039:Regional Blood Flow; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D013116:Spinal Cord / Q000098:blood supply*