title: Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism.
abstract: A [(18)F]-FDG PET study was performed in a 44 year old man with proximal kinesigenic choreoathetosis (PKC) secondary to idiopathic primary hypoparathyroidism (IPH) before and 1 year after calcium/calcitriol therapy. The [(18)F]-FDG PET performed before the start of the therapy disclosed a significant bilateral hypometabolism in the ventral striatum. One year later, with the patient still under calcium/calcitriol therapy and free of any occurrence of PKC episodes, the [(18)F]-FDG PET did not show the previously detected hypometabolism. The hypometabolism of the ventral striatum secondary to hypocalcaemia seems to play a crucial part in the pathogenesis of paroxysmal kinesigenic choreoathetosis associated with IPH.
authors.affiliation: Movement Disorder Unit, Department of Neuroscience, Istituto Scientifico Ospedale San Raffaele, Via Olgettina 60, 20132 Milano, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Volonté
authors.forename: D
authors.initials: D
authors.lastname: Perani
authors.forename: R
authors.initials: R
authors.lastname: Lanzi
authors.forename: A
authors.initials: A
authors.lastname: Poggi
authors.forename: D
authors.initials: D
authors.lastname: Anchisi
authors.forename: A
authors.initials: A
authors.lastname: Balini
authors.forename: G
authors.initials: G
authors.lastname: Comi
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D001928:Brain Diseases, Metabolic / Q000139:chemically induced*; D002117:Calcitriol / Q000009:adverse effects*; D002118:Calcium / Q000009:adverse effects*; D002819:Chorea / Q000188:drug therapy* / Q000209:etiology*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D002117:Calcitriol; D005947:Glucose; D002118:Calcium