[Protective effect of Astragalus membranaceus (Fisch.) Bge. and Hedysarum polybotrys Hand.-Mazz. on experimental model of cerebral ischemia in rats].
The experimental model of middle cerebral artery embolism in rats was made by inserting nylon thread. It was discovered that Astragalus membranaceus decoction(both 4.26 g.kg-1 and 7.1 g.kg-1) could reduce the capillary hyperpermeability and alleviate the dyskinesia caused by cerebral ischemia in rats. Purified Hedysarum polybotrys decoction (waste substances removed with alcohol after decocting with water) (12.5 g.kg-1) could reduce the water content in brain caused by occlusion of bilateral carotids in rats. Purified Hedysarum polybotrys decoction showed a tendency to reduce the water content in brain, but without statistical significance.
Quan
J
J
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700.
Du
G
G
D000818:Animals; D027885:Astragalus propinquus; D001929:Brain Edema / Q000188:drug therapy; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D002199:Capillary Permeability / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000145:classification / Q000494:pharmacology*; D007887:Fabaceae / Q000145:classification / Q000627:therapeutic use*; D008297:Male; D009069:Movement Disorders / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000494:pharmacology*; D008517:Phytotherapy; D010946:Plants, Medicinal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents