[Immunophenotype and P-glycoprotein expression in CD7 positive adult acute myeloid leukemia].
OBJECTIVE
To study the immunophenotype and P-glycoprotein expression in CD7 positive adult acute myeloid leukemia (CD7+ AML).


METHODS
Morphology, P-glycoprotein, cytogenetics and immunophenotype were examined in 30 previously untreated CD7+ AML patients.


RESULTS
The CD7 positive rate was 11.4% in 262 AML patients. CD7+ AML patients had a significantly higher incidence of peripheral leukocytosis and blasts and FAB M1 subtype and were associated with CD34 and P-glycoprotein expression. 42.3% of CD7+ AML achieved complete remission with a median remission duration of 4 months, and a median time to CR of 48 days.


CONCLUSIONS
Patients with CD7+ AML are usually CD34 and P-glycoprotein positive. These patients had a lower CR rate and a shorter remission duration.
Hua
D
D
First Affiliated Hospital, Suzhou Medical College, Jiangsu Institute of Hematology, Suzhou 215006.
Li
J
J
Xia
X
X
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000328:Adult; D018952:Antigens, CD34 / Q000276:immunology / Q000378:metabolism; D019011:Antigens, CD7 / Q000276:immunology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018952:Antigens, CD34; D019011:Antigens, CD7