Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats.
The dimethyl ester of L-glutamic acid (DMG) stimulates insulin release and was proposed as a possible insulinotropic tool in the treatment of non-insulin-dependent diabetes. In such a perspective, it was investigated whether DMG enhances the B-cell secretory response to GLP-1 in fed anaesthetized rats. The primed constant infusion of DMG (1.0 micromol and then 0.5 micromol/min, both per g body wt.) provoked a rapid and sustained increase in plasma insulin concentration and augmented the release of insulin caused by GLP-1. Thus, DMG indeed appears as a suitable tool to potentiate the insulinotropic action of GLP-1.
Cancelas
J
J
Fundacion Jimenez Diaz, Madrid, Spain.
Villanueva-Peñacarrillo
M L
ML
Valverde
I
I
Malaisse
W J
WJ
D000758:Anesthesia; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D004032:Diet; D004357:Drug Synergism; D005934:Glucagon / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D005971:Glutamates / Q000494:pharmacology*; D007328:Insulin / Q000097:blood*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001786:Blood Glucose; D005971:Glutamates; D007328:Insulin; D010446:Peptide Fragments; D011498:Protein Precursors; C035873:glutamic acid dimethyl ester; D052216:Glucagon-Like Peptide 1; D005934:Glucagon