title: Electroanalysis of dapsone, an anti-leprotic drug.
abstract: The electrochemical oxidation and adsorption of dapsone, an anti-leprotic drug were studied in aqueous alcohol medium at a stationary glassy carbon electrode. Cyclic voltammetry studies showed one well-defined oxidation peak in the potential range 1.2-1.9 V at pH conditions 1.0, 4.0, 7.0, 9.2 and 13.0. The oxidation was irreversible and exhibited diffusion controlled adsorption. Controlled potential coulometry revealed one electron oxidation of the amino group in the molecule. A systematic study of the experimental parameters that affect the squarewave stripping response was carried out and the optimized experimental conditions were arrived at. A calibration plot was derived for the determination of the compound in solution. This method was used for the determination of dapsone in tablets and urine. The limits of determination was 0.0036 and 3.56 mg/ml and the relative standard deviation (n=10) was 4 ppt (0.4%) at a concentration level 0.100 mg/ml.
authors.affiliation: Department of Industrial Chemistry, Alagappa University, Karaikudi-630 003, India. pms11@rediffmail.com
authors.forename: P
authors.initials: P
authors.lastname: Manisankar
authors.forename: A
authors.initials: A
authors.lastname: Sarpudeen
authors.forename: S
authors.initials: S
authors.lastname: Viswanathan
mesh_terms: D003622:Dapsone / Q000032:analysis* / Q000652:urine; D004563:Electrochemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007917:Leprostatic Agents / Q000032:analysis* / Q000652:urine; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
chemical_list: D007202:Indicators and Reagents; D007917:Leprostatic Agents; D013607:Tablets; D003622:Dapsone