title: New model of oropharyngeal candidiasis in mice.
abstract: We established a straightforward murine model of oropharyngeal candidiasis. Mice were immunosuppressed with cortisone acetate, anesthetized, and then inoculated by placing cotton wool balls saturated with Candida albicans sublingually for 2 h. A prolonged, reproducible infection was induced. This model may be useful for antifungal screening or pathogenesis studies.
authors.affiliation: Biological Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan. ykamai@shina.sankyo.co.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Kamai
authors.forename: M
authors.initials: M
authors.lastname: Kubota
authors.forename: Y
authors.initials: Y
authors.lastname: Kamai
authors.forename: T
authors.initials: T
authors.lastname: Hosokawa
authors.forename: T
authors.initials: T
authors.lastname: Fukuoka
authors.forename: S G
authors.initials: SG
authors.lastname: Filler
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002180:Candidiasis, Oral / Q000382:microbiology* / Q000473:pathology; D002452:Cell Count; D003348:Cortisone / Q000494:pharmacology; D004195:Disease Models, Animal; D004947:Esophagus / Q000473:pathology; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D010608:Pharyngeal Diseases / Q000382:microbiology* / Q000473:pathology; D013752:Tetracycline / Q000494:pharmacology; D014059:Tongue / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D013752:Tetracycline; D003348:Cortisone