title: Measuring threshold shifts for brain stimulation reward using the method of limits.
abstract: Thresholds determined from the frequency of pulses and the current for rewarding brain stimulation were obtained from rats with lateral hypothalamic electrodes. The threshold, defined as the frequency or current corresponding to one-half the maximum response rate, was interpolated from reward summation functions. Daily trials of both ascending and descending sequences of frequency and current yielded no significant difference between order of presentation. While there was more variability in the maximum response rates across the sessions, neither frequency- nor current-based threshold evaluations yielded significant rate effects. Our findings suggest that the threshold procedure is generally not influenced by the sequence of delivery of stimulus values and, thus, may be regarded as a reliable measure of the reinforcing properties of brain-stimulation reward.
authors.affiliation: University of Ottawa.
authors.forename: A T
authors.initials: AT
authors.lastname: Konkle
authors.forename: C
authors.initials: C
authors.lastname: Bielajew
authors.forename: G
authors.initials: G
authors.lastname: Fouriezos
authors.forename: A
authors.initials: A
authors.lastname: Thrasher
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000502:physiology*; D003216:Conditioning, Operant; D004558:Electric Stimulation; D008297:Male; D011601:Psychophysics; D051381:Rats; D020318:Rats, Long-Evans; D012201:Reward; D012653:Self Stimulation