title: [Different influences of genomic imprinting on the development of parthenogenetic cell clones in C57BL/6 and CBA mice].
abstract: Clonal analysis of parthenogenetic chimeric mouse embryos C57B1/6(PG)<-->BALB/c has shown that parthenogenetic cell clones C57BL/6 are present in the brain, liver, and kidneys of 14- and 18-day-old embryos. The content of the parthenogenetic component (PG) in these organs on day 18 was lower than on day 14, and, in some 18-day-old embryos, parthenogenetic cell clones were absent from the liver and/or kidneys. These data suggest that, during the embryogenesis of parthenogenetic chimeras, parthenogenetic cell clones of mostly endodermal and mesodermal origins were actively eliminated. Therefore, in such parthenogenetic adult chimeras, parthenogenetic clones of mostly ectodermal origins were preserved. In parthenogenetic chimeras CBA(PG)<-->BALB/c, parthenogenetic cell clones were actively eliminated at early embryonic stages, and, as a result, they were absent at the post-implantation stages. Hence, during development of parthenogenetic cell clones, the effects of genomic imprinting are expressed unequally in C57BL/6 and CBA mice.
authors.affiliation: Vavilov Institute of General Genetics, Russian Academy of Sciences, ul. Gubkina 3, Moscow, 117809 Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Isaev
authors.forename: M I
authors.initials: MI
authors.lastname: Martynova
authors.forename: E C
authors.initials: EC
authors.lastname: Platonov
authors.forename: B V
authors.initials: BV
authors.lastname: Koniukhov
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000502:physiology; D002678:Chimera; D002999:Clone Cells; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D018392:Genomic Imprinting; D007668:Kidney / Q000196:embryology / Q000502:physiology; D008099:Liver / Q000196:embryology / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008808:Mice, Inbred CBA / Q000235:genetics*; D010312:Parthenogenesis
vernacular_title: Razlichnoe vliianie genomnogo imprintinga na razvitie partenogeneticheskikh kletochnykh klonov myshei C57BL/6 i CBA.