In vivo and in vitro nuclear magnetic resonance spectroscopy investigation of an intracranial mass.
This study shows how 1H magnetic resonance spectroscopy (1H MRS) can help to elucidate a clinical case when MR images suggest a diagnosis of central nervous system (CNS) neoplasm. The in vivo MRS metabolic profile in our cases did not correspond to literature reports of brain tumors, but reflected the histopathological response of hematoma and the in vitro 1H MR spectra of the biopsy obtained at surgery. The in vitro spectrum of the aqueous extracts of the examined lesion were compared with those of two common CNS tumors. The lipid fraction spectrum of the lesion agreed with both the spectrum of the aqueous extracts and the histological diagnosis.
Tosi
M R
MR
Istituto di Citomorfologia Normale e Patalogica del CNR, I-Bologna 40136, Italy. raftosi@ciam.unibo.it
Ricci
R
R
Bottura
G
G
Tugnoli
V
V
D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006406:Hematoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed