title: Dextran reduces embolic signals after carotid endarterectomy.
abstract: One hundred fifty patients undergoing carotid endarterectomy were randomly assigned to receive intravenous 10% dextran 40 or placebo. Transcranial Doppler monitoring of the ipsilateral middle cerebral artery 0 to 1 hour postoperatively detected embolic signals in 57% of placebo and 42% of dextran patients, with overall embolic signal counts 46% less for dextran (p = 0.052). Two to 3 hours postoperatively, embolic signals were present in 45% of placebo and 27% of dextran patients, with embolic signal counts 64% less for dextran (p = 0.040). We conclude that dextran reduces embolic signals within 3 hours of CEA.
authors.affiliation: Department of Neurology, John Hunter Hospital, Newcastle, Australia.
authors.forename: C R
authors.initials: CR
authors.lastname: Levi
authors.forename: J L
authors.initials: JL
authors.lastname: Stork
authors.forename: B R
authors.initials: BR
authors.lastname: Chambers
authors.forename: A L
authors.initials: AL
authors.lastname: Abbott
authors.forename: H M
authors.initials: HM
authors.lastname: Cameron
authors.forename: A
authors.initials: A
authors.lastname: Peeters
authors.forename: J P
authors.initials: JP
authors.lastname: Royle
authors.forename: A K
authors.initials: AK
authors.lastname: Roberts
authors.forename: G
authors.initials: G
authors.lastname: Fell
authors.forename: M C
authors.initials: MC
authors.lastname: Hoare
authors.forename: A T
authors.initials: AT
authors.lastname: Chan
authors.forename: G A
authors.initials: GA
authors.lastname: Donnan
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D016893:Carotid Stenosis / Q000601:surgery; D003911:Dextrans / Q000008:administration & dosage*; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D020766:Intracranial Embolism / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000517:prevention & control; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D000925:Anticoagulants; D003911:Dextrans