Wavelets of excitability in sensory neurons.
We have investigated variations in the excitability of mammalian cutaneous mechanoreceptor neurons. We focused on the phase dynamics of an action potential relative to a periodic stimulus, showing that the excitability of these sensory neurons has interesting nonstationary oscillations. Using a wavelet analysis, these oscillations were characterized through the depiction of their period as a function of time. It was determined that the induced oscillations are weakly dependent on the stimulus frequency, and that lower temperatures significantly reduce the frequency of the phase response. Our results reveal novel excitability properties in sensory neurons, and, more generally, could prove significant in the deduction of mechanistic attributes underlying the nonstationary excitability in neuronal systems. Since peripheral neurons feed information to the CNS, variable responses observed in higher regions may be generated in part at the site of sensory detection.
Hasty
J
J
Center for BioDynamics and Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA. hasty@bu.edu
Collins
J J
JJ
Wiesenfeld
K
K
Grigg
P
P
D000818:Animals; D008465:Mechanoreceptors / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*; D010507:Periodicity; D010812:Physical Stimulation; D051381:Rats; D012867:Skin / Q000294:innervation