[Embryonic stem cells and therapeutic cloning].
Increased interest in the therapeutic use of human stem cells has emerged following significant progress in ongoing research. The cloning of a sheep, the isolation of human embryonic stem cells, and the discovery that adult stem cells may be reprogrammed taken together give substance to hopes that novel principles of treatment may be developed for a variety of serious conditions. Embryonic stem cells are derived from pre-embryos at the blastocyst stage and may give rise to all bodily tissues and cells. Animal models have demonstrated that embryonic stem cells when transplanted into adult hosts may differentiate and develop into cells and tissues applicable for treatment of a variety of conditions, including Parkinson's disease, multiple sclerosis, spinal injuries, cardiac stroke and cancer. Transplanted embryonic stem cells are exposed to immune reactions similar to those acting on organ transplants, hence immunosuppression of the recipient is generally required. It is, however, possible to obtain embryonic stem cells that are genetically identical to the patient's own cells by means of therapeutic cloning techniques. The nucleus from a somatic cell is transferred into an egg after removal of the egg's own genetic material. Under specific condition the egg will use genetic information from the somatic cell in organising the formation of a blastocyst which in turn generates embryonic stem cells. These cells have a genetic composition identical to that of the patient and are suitable for stem cell therapy.
Sunde
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A
Kvinneklinikken, Regionsykehuset i Trondheim 7006 Trondheim. arne.sunde@medisin.ntnu.no
Eftedal
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I
D000328:Adult; D000818:Animals; D001755:Blastocyst / Q000502:physiology; D002454:Cell Differentiation; D002469:Cell Separation; D002999:Clone Cells; D019976:Cloning, Organism / Q000379:methods*; D004992:Ethics, Medical; D016332:Fetal Tissue Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D013234:Stem Cells / Q000276:immunology / Q000502:physiology*
Embryonale stamceller og terapeutisk kloning.