Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity.
This article investigates the relationship between the polymorphic variations in genes associated with cardiovascular disease and longevity in the Danish population. A new procedure that combines both demographic and the individual genetic information in determining the relative risks of the observed genetic variations is applied. The sex-dependent influences can be found by introducing sex-specific population survival and incorporating the risk of gene-sex interaction. Three genetic polymorphisms, angiotensinogen M/T235, blood coagulation factor VII (FVII) R/Q353 and FVII-323ins10, manifest significant influences on survival in males, with reduced hazards of death for carriers of the angiotensinogen M235 allele, the F VII Q353 allele, and the FVII-323P10 allele. The results show that some of these genotypes associated with lower risk of CVD could also reduce the carrier's death rate and contribute to longevity. However, the presence of sex-dependent effects and the fact that major CVD-associated genes failed to impose detrimental influence on longevity lead us to concur that the aging process is highly complicated.
Tan
Q
Q
Max-Planck Institute for Demographic Research, Rostock, Germany.
Yashin
A I
AI
Bladbjerg
E M
EM
de Maat
M P
MP
Andersen-Ranberg
K
K
Jeune
B
B
Christensen
K
K
Vaupel
J W
JW
D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics*; D003718:Denmark / Q000453:epidemiology; D005167:Factor VII / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012727:Sex Characteristics; D016019:Survival Analysis
D000808:Angiotensinogen; D005167:Factor VII