Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin.
We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of beta-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various beta-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.
Shimizu
M
M
Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700-8530, Japan.
Shiota
S
S
Mizushima
T
T
Ito
H
H
Hatano
T
T
Yoshida
T
T
Tsuchiya
T
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002852:Chromatography, Ion Exchange; D004357:Drug Synergism; D005960:Glucosides / Q000494:pharmacology*; D047348:Hydrolyzable Tannins; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005960:Glucosides; D047348:Hydrolyzable Tannins; D010406:Penicillins; D010936:Plant Extracts; C049096:corilagin; D010068:Oxacillin