Elevated blood pressure in subjects with lipodystrophy.
OBJECTIVE
To assess the prevalence of elevated blood pressure in patients with lipodystrophy.


METHODS
Case-control study.


METHODS
Forty-two patients with abnormal body fat (100%) and serum lipids (86%) (HIV-positive cohort) were matched by age and sex to 42 HIV-positive controls without previously diagnosed lipodystrophy and to 13 HIV-negative controls.


METHODS
Tertiary care, university-based, fully dedicated HIV clinic.


METHODS
Frequency and magnitude of elevated blood pressure during highly active antiretroviral therapy.


RESULTS
There were 23 +/- 16 and 22 +/- 12 blood pressure measurements recorded per subject over 21 +/- 11 and 22 +/- 11 months for the HIV-positive cohort and HIV-positive controls, respectively. Three or more elevated readings occurred in 74% of the cohort and in 48% of the HIV-positive controls (P = 0.01) and accounted for 38 +/- 25% versus 22 +/- 26% (P = 0.01) of the total readings, respectively. The average of the three highest systolic readings (153 +/- 17 versus 144 +/- 15 mmHg; P = 0.01) and diastolic readings (92 +/- 10 versus 87 +/- 9 mmHg; P = 0.01) was greater for the cohort than for the HIV-positive controls. Family history of hypertension was more common in the cohort than in the controls but accounted for only 13% of the log odds ratio value for elevated blood pressure in the cohort. Systolic blood pressure was correlated with waist-to-hip ratios in the cohort (r = 0.45; P = 0.003) but not in the HIV controls (r = 0.06; P = 0.68) and tended to be related to fasting triglycerides (r = 0.34; P = 0.052) in subjects with HIV.


CONCLUSIONS
Elevated blood pressure may be linked to the metabolic disorders occurring in patients with HIV, as in the dysmetabolic syndrome.
Sattler
F R
FR
Division of Infectious Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Qian
D
D
Louie
S
S
Johnson
D
D
Briggs
W
W
DeQuattro
V
V
Dube
M P
MP
D000273:Adipose Tissue; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001794:Blood Pressure; D001823:Body Composition; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D008060:Lipodystrophy / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D044465:White People
D008055:Lipids