In vitro susceptibility of Coxiella burnetii to linezolid in comparison with its susceptibilities to quinolones, doxycycline, and clarithromycin.
The in vitro susceptibility to linezolid shown by nine Greek isolates of Coxiella burnetii derived from patients with acute Q fever was investigated. MICs of linezolid were compared with those of pefloxacin, ciprofloxacin, ofloxacin, trovafloxacin, doxycycline, and clarithromycin using the shell vial assay. MICs of linezolid and clarithromycin ranged from 2 to 4 microg/ml; those of doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 microg/ml; those of pefloxacin ranged from 1 to 4 microg/ml; and those of ciprofloxacin ranged from 4 to 8 microg/ml. Linezolid was effective in controlling intracellular parasites in cultures of Vero cells infected by C. burnetii. No bactericidal activity by linezolid was obtained against C. burnetii at 8 microg/ml.
Gikas
A
A
Clinical Bacteriology, Parasitology, Zoonoses, and Geographical Medicine, Collaborating Center of WHO, University of Heraklion, 1352/71110 Crete, Greece. gikas@med.uoc.gr
Spyridaki
I
I
Scoulica
E
E
Psaroulaki
A
A
Tselentis
Y
Y
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D017291:Clarithromycin / Q000494:pharmacology*; D016997:Coxiella burnetii / Q000187:drug effects*; D004318:Doxycycline / Q000494:pharmacology*; D024841:Fluoroquinolones; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D011778:Q Fever / Q000382:microbiology; D014709:Vero Cells
D000081:Acetamides; D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D023303:Oxazolidinones; D017291:Clarithromycin; D000069349:Linezolid; D004318:Doxycycline