title: Alkylation of 2-phenyl-4-quinolones: synthetic and structural studies.
abstract: The alkylation of 2-phenyl-4-quinolones was investigated and showed that the N-alkylation versus O-alkylation is highly dependent on whether C-5 is hydroxylated or not. N-Alkylation is favoured by the presence of a 5-hydroxyl group. The synthetic and the NMR structural studies are reported.
authors.affiliation: Laboratory of pharmacognosy, UMR-UNRS 5063, Grenoble pharmacy school 3870 La Tornche, France.
authors.forename: M
authors.initials: M
authors.lastname: Hadjeri
authors.forename: A M
authors.initials: AM
authors.lastname: Mariotte
authors.forename: A
authors.initials: A
authors.lastname: Boumendjel
mesh_terms: D000478:Alkylation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D015363:Quinolones; C084179:2-phenyl-4-oxohydroquinoline