Fatal graft-versus-host disease following HLA-mismatched donor lymphocyte infusion.
We report the case of a 10-year-old boy with molecular relapse of CML following unrelated donor BMT who developed fatal grade 4 acute GVHD of the gut and liver following one antigen-mismatched donor lymphocyte infusion. Previous experience of donor lymphocyte infusion in the HLA-mismatched setting is reviewed and the role of adoptive immunotherapy in this situation is discussed.
Amrolia
P J
PJ
Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK.
Rao
K
K
Slater
O
O
Ramsay
A
A
Veys
P A
PA
Webb
D K
DK
D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology; D002648:Child; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000209:etiology*; D006648:Histocompatibility; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy; D017710:Lymphocyte Transfusion / Q000009:adverse effects*; D008297:Male; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000276:immunology