title: [Assessing the informative value of positron emission tomography with the new radiopharmaceutical Sodium 11C-butyrate versus small-dose dobutamine stress echocardiography in the diagnosis of myocardial viability in patients with coronary heart disease and left ventricular dysfunction].
abstract: Myocardial viability in patients with coronary artery disease and heart failure was assessed by echocardiography with low doses of dobutamine and positron emission tomography with Sodium 11C-butyrate. Sensitivity and specificity of those methods were compared. Positron emission tomography and Sodium 11C-butyrate had quite high sensitivity and specificity, which could be compared with positron emission tomography and fluorine-18-deoxyglucose. Echocardiography with low doses of dobutamine had high specificity and its sensitivity was lower that one of positron emission tomography and Sodium 11C-butyrate. Thus, it is necessary to use the protocol of stress dobutamine echocardiography with high doses to avoid this problem.
authors.affiliation: Central Research Institute of X-ray and Radiation Studies, Ministry of Health, Russian Federation, I. P. Pavlov Saint Petersburg State Medical University.
authors.forename: D
authors.initials: D
authors.lastname: Ryzhkova
authors.forename: L
authors.initials: L
authors.lastname: Tiutin
authors.forename: N
authors.initials: N
authors.lastname: Kostenikov
authors.forename: E
authors.initials: E
authors.lastname: Nifontov
authors.forename: E
authors.initials: E
authors.lastname: Shliakhto
authors.forename: V
authors.initials: V
authors.lastname: Savello
authors.forename: O
authors.initials: O
authors.lastname: Rudomanov
authors.forename: D
authors.initials: D
authors.lastname: Zakharov
authors.forename: V
authors.initials: V
authors.lastname: Kazarin
mesh_terms: D000328:Adult; D000368:Aged; D002087:Butyrates / Q000493:pharmacokinetics; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D002316:Cardiotonic Agents; D003327:Coronary Disease / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D004280:Dobutamine; D025401:Echocardiography, Stress; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D002087:Butyrates; D002250:Carbon Radioisotopes; D002316:Cardiotonic Agents; D004280:Dobutamine
vernacular_title: Sravnitel'naia otsenka informativnisti positronnoi emissionnoi tomografii s nov"m radiofarmpreparatom 11S-butiratom natriia i stress-ekhocardiografii s malymi dozami dobutamina v diagnostike zhiznecposobnosti miokarda u bol'nykh ishemicheskoi bolezn'iu serdtsa s disfunktsiei levogo zheludochka