title: [Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver].
abstract: Two patients, both women aged 31 and 73 years, were admitted with chest pain and coma, respectively. They had very high aspartate aminotransferase levels, accompanied by relatively low alanine aminotransferase levels. The second patient had developed acute liver failure and hepatic encephalopathy. Both patients were chronic alcohol abusers and had taken therapeutic doses of acetaminophen for a couple of days. The marked elevation of the aminotransferase levels and the rapid decline of these levels after discontinuing the use of acetaminophen and alcohol led to the diagnosis of acetaminophen hepatotoxicity. In chronic alcohol abusers, cytochrome P450 2E1 is induced and the amount of glutathione is depleted. This combination causes the formation of a relatively large amount of the radical N-acetyl-p-benzoquinone imine and a low potential to detoxify this metabolite, so that even small amounts of acetaminophen may cause liver damage. It is recommended that chronic alcohol abusers (more than four alcoholic beverages per day) use no more than 2 g acetaminophen per day.
authors.affiliation: Rijnland Ziekenhuis, afd. Interne Geneeskunde en Maag-Darm-Leverziekten, Postbus 4220, 2350 CC Leiderdorp.
authors.forename: A H
authors.initials: AH
authors.lastname: van Mil
authors.forename: A R
authors.initials: AR
authors.lastname: Janssens
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000378:metabolism; D000437:Alcoholism / Q000150:complications* / Q000378:metabolism; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D001219:Aspartate Aminotransferases / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D005260:Female; D018565:Food-Drug Interactions; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D008107:Liver Diseases / Q000097:blood / Q000201:enzymology; D008111:Liver Function Tests; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D019392:Cytochrome P-450 CYP2E1; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
vernacular_title: Paracetamol bij chronisch alcoholgebruik: weinig is voor de lever snel teveel.