title: Effects of rhidosin on expression of fibroblast growth factor on olfactory bulb in rats and its relation with senile hyposmia.
abstract: OBJECTIVE
  To determine the expression of fibroblast growth factor (FGF) on olfactory bulb in rats and its relation with senile hyposmia, and to discuss the effects of rhidosin on expression of FGF on olfactory bulb in senile rats and its significance.
  
  
  METHODS
  Four groups of rats, i.e., young group, senile group, rhidosin group, and physiological saline control group were used in this study. After the removal of the heads of these rats, olfactory mucosa and olfactory bulbs were immediately fixed with neutral formalin, followed with paraffin-embedding, serial sectioning, immunohistochemical staining and light microscopic observation.
  
  
  RESULTS
  The positive expression rate of FGF on olfactory bulb in young group was significantly higher than that in senile group (P < 0.01). The positive expression rate of FGF on olfactory bulb in rhidosin group was significantly higher than that in physiological saline control group (P < 0.01). No positive expression of FGF on olfactory mucosa was observed in these four groups.
  
  
  CONCLUSIONS
  These results suggest that the expression of FGF on olfactory bulb gradually decline with aging. The decrease of expression of FGF on olfactory bulb may play a key role in the occurrence of senile hyposmia. Rhidosin can increase the expression of FGF on olfactory bulbs in senile rats and this may be one of the mechanisms by which rhidosin promotes the growth of olfactory cells and inhibits aging effects on the olfactory system.
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Third Teaching Hospital, Bethune University of Medical Sciences, Changchun 130031, China. wangyipe@public.cc.jl.cn
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Guan
authors.forename: Z
authors.initials: Z
authors.lastname: Dong
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005346:Fibroblast Growth Factors / Q000096:biosynthesis*; D008297:Male; D000857:Olfaction Disorders / Q000503:physiopathology*; D009830:Olfactory Bulb / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal; D005346:Fibroblast Growth Factors