title: Plexin signaling via off-track and rho family GTPases.
abstract: Two papers in this issue of Neuron examine new aspects of Semaphorin signaling via Plexin receptors. Winberg et al. present evidence that the transmembrane protein Off-track (OTK) interacts biochemically and genetically with Plexin A and is important for Sema 1a repulsive signaling. Hu et al. examine the coupling of Plexin B to Rac and RhoA and propose that Plexin B signaling involves inhibition of Rac function by direct sequestration and simultaneous activation of RhoA.
authors.affiliation: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Whitford
authors.forename: A
authors.initials: A
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D029721:Drosophila Proteins; D008565:Membrane Proteins / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D011505:Protein-Tyrosine Kinases; D017468:Receptors, Fibroblast Growth Factor; D015398:Signal Transduction / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D017468:Receptors, Fibroblast Growth Factor; C091529:plexin; D011505:Protein-Tyrosine Kinases; C102667:htl protein, Drosophila; D020741:rho GTP-Binding Proteins