title: Angiogenesis in adipose tissues and skeletal muscles with rebound weight-gain after diet-restriction in rabbits.
abstract: The mechanisms of excessive body weight gain after diet-restriction are still unclear. In this study, we investigated expression of angiogenic factors in adipose tissue and skeletal muscle of rabbits which had rebound weight gains; trying to make inquiries into the mechanisms of this rebound weight gain. Ten rabbits were divided into two groups. One group had free food intake (group C), and the other group had restricted food intake until day 40 of the experiments and then had free food intake (group DR). Specimens of adipose tissue and skeletal muscle were collected from each rabbit on days 20, 40, and 60 after the initial examination, and expressions of CD34, vascular endothelial growth factor (VEGF), and platelet-derived endothelial cell growth factor (PD-ECGF) were investigated. Expression of VEGF was significantly strong in the adipose tissue of group DR at the recovery period of body weight. In conclusion, rebound weight gain after a restricted-diet may be associated with angiogenesis in adipose tissue, and the angiogenesis may be induced by VEGF.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Morimura
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: T
authors.initials: T
authors.lastname: Sumi
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000648:ultrastructure; D000273:Adipose Tissue / Q000098:blood supply / Q000378:metabolism* / Q000648:ultrastructure; D043925:Angiogenesis Inducing Agents / Q000096:biosynthesis*; D000818:Animals; D018952:Antigens, CD34 / Q000032:analysis; D001808:Blood Vessels / Q000737:chemistry / Q000254:growth & development; D015153:Blotting, Western; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004038:Diet, Reducing; D004435:Eating; D016228:Endothelial Growth Factors / Q000032:analysis; D007150:Immunohistochemistry; D008222:Lymphokines / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism* / Q000648:ultrastructure; D011817:Rabbits; D013939:Thymidine Phosphorylase / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D015430:Weight Gain / Q000502:physiology*
chemical_list: D043925:Angiogenesis Inducing Agents; D018952:Antigens, CD34; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013939:Thymidine Phosphorylase