Toxicant-induced oxidative stress in cancer.
The article highlighted in this issue is "The Role of Oxidative Stress in Indium Phosphide-Induced Lung Carcinogenesis in Rats" by Barbara C. Gottschling, Robert R. Maronpot, James R. Hailey, Shyamal Peddada, Cindy R. Moomaw, James E. Klaunig, and Abraham Nyska (pp. 28-40). The article integrates a traditional pathologic study of toxicant-induced pulmonary carcinogenesis with an immunohistologic assessment of oxidative stress, thereby determining a potential mechanism of action of a toxicant, specifically indium phosphide.
Upham
B L
BL
National Food Safety and Toxicology Center, Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824-1317, USA. upham@pilot.msu.edu
Wagner
J G
JG
D000818:Animals; D015415:Biomarkers; D006801:Humans; D007204:Indium / Q000633:toxicity*; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress; D010720:Phosphines / Q000633:toxicity*
D015415:Biomarkers; D016877:Oxidants; D010720:Phosphines; D007204:Indium; C090882:indium phosphide