Melatonin: a significant contributor to the pathogenesis of migraine.
It is generally accepted that migraine is caused by a primary biochemical disorder of the central nervous system involving neurotransmitters, specifically serotonin. The pathogenetic mechanism triggered by external and internal stimuli is not well explained or understood. This article points to the possibility that the pineal gland, a primary source of central serotonin and melatonin, contributes significantly to migraine attacks.
Toglia
J U
JU
Temple University Health Sciences Center, Philadelphia, Pennsylvania 19141, USA.
D006801:Humans; D008550:Melatonin / Q000502:physiology*; D008881:Migraine Disorders / Q000503:physiopathology*; D010870:Pineal Gland / Q000503:physiopathology; D012701:Serotonin / Q000134:cerebrospinal fluid / Q000502:physiology
D012701:Serotonin; D008550:Melatonin