Efficacies of clarithromycin regimens against Mycobacterium xenopi in mice.
Mice were infected intravenously with 3.5 x 10(7) CFU of Mycobacterium xenopi and treated with various clarithromycin-containing regimens or left untreated for 4 weeks. All nine of the clarithromycin-containing regimens reduced the CFU counts to the levels below the pretreatment values, indicating that these regimens had a bactericidal effect on M. xenopi in mice. The rifampin-isoniazid-ethambutol regimen was significantly less bactericidal than clarithromycin alone or clarithromycin-containing combined regimens.
Lounis
N
N
Laboratoire de Bactériologie-Hygiène, Faculté de Médecine Pitié-Salpêtrière, Paris, France. lounis@chups.jussieu.fr
Truffot-Pernot
C
C
Bentoucha
A
A
Robert
J
J
Ji
B
B
Grosset
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004359:Drug Therapy, Combination; D005260:Female; D024841:Fluoroquinolones; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D019912:Mycobacterium xenopi; D009929:Organ Size / Q000502:physiology; D013154:Spleen / Q000382:microbiology / Q000473:pathology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D017291:Clarithromycin