title: Origins of the Creutzfeldt and Jakob concept.
abstract: A review of the publications of Hans Creutzfeldt and Alfons Jakob pertaining to the concept which bears their name (CJD) reveals that they described a neuropathological syndrome and were opposed to its classification as a neurological disease. The evidence on which Creutzfeldt and Jakob based their view is reevaluated, and studies by other workers are cited in which a range of environmental and genetic factors generated the CJ syndrome, challenging the proposition that CJD is a disease with a single cause.
authors.affiliation: Jefferson Medical College of the Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Duckett
authors.forename: J
authors.initials: J
authors.lastname: Stern
mesh_terms: D007562:Creutzfeldt-Jakob Syndrome / Q000266:history*; D005858:Germany; D049673:History, 20th Century; D006801:Humans