title: Bone metastasis from a granulosa cell tumor of the ovary.
abstract: BACKGROUND
  Granulosa cell tumors (GCT) of the ovary generally have a good prognosis. Recurrences tend to be late and are usually abdominopelvic. Bone metastases are extremely rare.
  
  
  METHODS
  A case of recurrent GCT with vertebral metastasis is presented. Radiologic studies were helpful in documenting the presence of an invasive tumor destroying the vertebral body of T7. Bone scintigraphy excluded other metastatic sites. Diagnosis could not be established by CT-scan-directed fine-needle aspiration cytology or trocar biopsies. Since the lesion was isolated and resectable, aggressive surgery with complete tumoral excision was performed followed by local radiation therapy. Megestrol acetate was given as systemic treatment.
  
  
  CONCLUSIONS
  Multiple treatments of GCT may alter the pattern of recurrence. Every symptom should be thoroughly evaluated. Bone metastases may be treated aggressively.
authors.affiliation: Department of Obstetrics and Gynecology, University of Montreal, Montreal, Quebec, H2L 4M1, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Dubuc-Lissoir
authors.forename: M J
authors.initials: MJ
authors.lastname: Berthiaume
authors.forename: G
authors.initials: G
authors.lastname: Boubez
authors.forename: T
authors.initials: T
authors.lastname: Van Nguyen
authors.forename: G
authors.initials: G
authors.lastname: Allaire
mesh_terms: D001859:Bone Neoplasms / Q000378:metabolism* / Q000628:therapy; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy; D013904:Thoracic Vertebrae / Q000473:pathology*