title: Propionic acid production in an in situ cell retention bioreactor.
abstract: Continuous fermentations were conducted with in situ cell retention using spin filters (pore size 5 microm and 10 microm) for propionic acid production by Propionibacterium acidipropionici. Continuous fermentation with a 5-microm pore size spin filter resulted in 50% cell retention. Propionic acid productivity was enhanced (0.9 g l(-1) h(-1)) by approximately four-fold compared to conventional batch fermentation (0.25 g l(-1) h(-1)). The in situ cell retention (5-microm pore size spin filter) bioreactor was operated continuously and smoothly for 8 days at a dilution rate of D=0.05 h(-1).
authors.affiliation: Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi.
authors.forename: V
authors.initials: V
authors.lastname: Goswami
authors.forename: A K
authors.initials: AK
authors.lastname: Srivastava
mesh_terms: D019149:Bioreactors; D001709:Biotechnology / Q000295:instrumentation / Q000379:methods; D003470:Culture Media; D005285:Fermentation; D005374:Filtration / Q000295:instrumentation / Q000379:methods; D011422:Propionates / Q000378:metabolism*; D011424:Propionibacterium / Q000254:growth & development / Q000378:metabolism*
chemical_list: D003470:Culture Media; D011422:Propionates; C029658:propionic acid