Regulation of lipid and lipoprotein metabolism by retinoids.
Retinoids are small vitamin A-derived lipophilic compounds that influence a wide variety of developmental and metabolic processes. Retinoids exert their action by activating transcription factors belonging to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) subfamilies of nuclear receptors. Therapeutically, retinoids are used for the treatment of dermatological disorders and certain cancers. Dyslipidemia is a common side-effect of therapy with the currently available retinoids. This review summarizes our current understanding of the molecular mechanisms of regulation of lipid and lipoprotein metabolism by retinoids.
Staels
B
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Département d'Athérosclérose, INSERM U325, Institut Pasteur de Lille, i rue Calmette, 59019 Lille, France. Bart.Staels@pasteur-lille.fr
D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced*; D008024:Ligands; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism*; D018168:Receptors, Retinoic Acid / Q000096:biosynthesis / Q000502:physiology; D047488:Retinoid X Receptors; D012176:Retinoids / Q000009:adverse effects / Q000494:pharmacology*; D012307:Risk Factors; D012871:Skin Diseases / Q000188:drug therapy; D014157:Transcription Factors / Q000096:biosynthesis / Q000502:physiology
D008024:Ligands; D008074:Lipoproteins; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D012176:Retinoids; D014157:Transcription Factors