title: Diagnosis of bone infection using 99m Tc-HMPAO labelled leukocytes.
abstract: In order to evaluate the importance of 99mTc-hexamethylpropylene amine oxime (99mTc-HMPAO) leukocyte scintigraphy in the diagnosis of bone infection, we retrospectively reviewed 324 patients. Abnormal findings were seen in 221 patients. In the other 103 cases acute pathological inflammation could be ruled out. The patients with pathological findings were divided into four groups according to the location of the infection. This method showed the localizations of skeletal disorders and its differences to other diagnostic imaging modalities. The underlying abnormalities causing the inflammation were determined. In conclusion, 99mTc-HMPAO leukocyte scintigraphy is still a very sensitive method for either whole body screening or local detection of acute or exacerbated chronic osteomyelitis. The advantages of this method over other diagnostic imaging methods are shown.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Karl-Franzens-University Graz, Auenbruggerplatz 9, A - 8036 GRAZ, Austria. ge.wolf@kfunigraz.ac.at
authors.forename: G
authors.initials: G
authors.lastname: Wolf
authors.forename: R M
authors.initials: RM
authors.lastname: Aigner
authors.forename: T
authors.initials: T
authors.lastname: Schwarz
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019643:Arthroplasty, Replacement; D001850:Bone Diseases, Infectious / Q000000981:diagnostic imaging*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007249:Inflammation; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D012189:Retrospective Studies; D019690:Technetium Tc 99m Exametazime; D014947:Wounds and Injuries / Q000000981:diagnostic imaging
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime