title: Severe complication after administration of formalin for treatment of progressive ethmoidal hematoma in a horse.
abstract: Formalin was injected into an ethmoidal hematoma in an 18-year-old Arabian gelding. Abnormal neurologic signs were observed within minutes of the injection. The horse did not respond favorably to medical treatment of the neurologic signs and was euthanatized. Postmortem examination revealed erosion and necrosis of the ventral cribriform plate, which appeared to have allowed the injected formalin to reach the rostral portion of the frontal lobe of the brain. Endoscopy and radiography had been performed prior to euthanasia, but neither delineated the cribriform lesion. Before treating large progressive ethmoidal hematomas with formalin, it may be beneficial to perform computed tomography to assess the extent of damage caused by the lesion.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Frees
authors.forename: E M
authors.initials: EM
authors.lastname: Gaughan
authors.forename: J D
authors.initials: JD
authors.lastname: Lillich
authors.forename: J
authors.initials: J
authors.lastname: Cox
authors.forename: D
authors.initials: D
authors.lastname: Gorondy
authors.forename: J C
authors.initials: JC
authors.lastname: Nietfeld
authors.forename: G A
authors.initials: GA
authors.lastname: Kennedy
authors.forename: W
authors.initials: W
authors.lastname: Cash
mesh_terms: D000818:Animals; D005004:Ethmoid Bone / Q000473:pathology; D005005:Ethmoid Sinus; D017809:Fatal Outcome; D005557:Formaldehyde / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006406:Hematoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D006734:Horse Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006736:Horses; D015552:Injections, Intralesional / Q000662:veterinary; D008297:Male; D010254:Paranasal Sinus Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*
chemical_list: D005557:Formaldehyde