title: Very long survival in pediatric cancer between 1944 and 1993.
abstract: OBJECTIVE
  To identify factors associated with very long survival among all cancer cases diagnosed at age 19 years or younger registered by the Cancer Data Service at the University of Kansas Medical Center in Kansas City, Kansas, U.S.A. in the 40-year period between 1944 and 1983, with follow-up to 1993.
  
  
  METHODS
  There were 2720 pediatric patients with 2750 cancers who were studied. Forty-four types of cancer were grouped into 11 diagnostic categories. Diagnosis years spanned four eras: 1944-1953, 1954-1963, 1964-1973, and 1974-1983. Cases were compared using specific characteristics and were divided into short-term and long-term survivors with the division generously set at seven years. The proportions of the long-term survivors were compared by specific characteristics.
  
  
  RESULTS
  Among the diagnostic categories, leukemias were the most common (29.8%), followed by CNS tumors (15.2%), and Hodgkin's disease (9.0%). Male to female ratio was 4:3; average age at diagnosis was 8.83 +/- 6.08 years. Long-term survivors totaled 1148 (41.7%). Prognosis was better in cases diagnosed in earlier stages and in later eras. Proportion of long-term survivors increased from 18.7% in era I to 52.6% in era IV. Improvement of survival was statistically significant in most diagnostic categories.
  
  
  CONCLUSIONS
  This study shows continuing improvement of survival during four consecutive eras for childhood and adolescent cancer. Early diagnosis was associated with better survival. Unstaged cases decreased over time reflecting progress in diagnostic techniques. Many patients died before seven years after diagnosis. Those who survived more than seven years had excellent survival. Pediatricians can expect to participate in the care of these patients long after the original dianosis and treatment.
authors.affiliation: Henan Institute of Medical Sciences, Henan Medical University, Henan 450052, China.
authors.forename: G
authors.initials: G
authors.lastname: Zhao
authors.forename: C D
authors.initials: CD
authors.lastname: Boysen
authors.forename: E F
authors.initials: EF
authors.lastname: Brown
authors.forename: K M
authors.initials: KM
authors.lastname: Hassanein
authors.forename: F F
authors.initials: FF
authors.lastname: Holmes
authors.forename: G E
authors.initials: GE
authors.lastname: Holmes
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000401:mortality*; D006801:Humans; D007223:Infant; D007615:Kansas / Q000453:epidemiology; D007680:Kidney Neoplasms / Q000401:mortality; D007938:Leukemia / Q000401:mortality*; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality; D008297:Male; D012175:Retinoblastoma / Q000401:mortality*; D012737:Sex Factors; D015996:Survival Rate; D009396:Wilms Tumor / Q000401:mortality*