[Experimental models: interactions Synercid and beta-lactam antibiotics].
SYNERCID ALONE IN A RAT MODEL OF EXPERIMENTAL ENDOCARDITIS: Trials conducted using 2 injections daily showed that animals infected with meti-R resistant Staphylococcus aureus strains sensitive to erythromycin were cured in 3 days. The same is not true for infections caused by C-MLSB-R staphylococci. The daily dose cannot be increased due to the venous toxicity of Synercid, leading to the idea of testing Synercid in combination with other antibiotics.


METHODS
Several antibiotics have been tested in combination with Synercid. Several beta-lactams have been shown to exhibit an additive or synergetic effect on a collection of meti-R and meti-S S. aureus strains.


METHODS
In animals infected with C-MLSB-R meti-R S. aureus, the combination Synercid + cefepime increases the activity of cefipime and prevents selection of beta-lactam highly resistant strains. The results obtained with the Synercid + cefpirome combination are even more eloquent. Finally, Synercid, alone or in combination with these 2 cephalosporins, does not select resistant strains.
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CHUV Lausanne.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D006801:Humans; D051381:Rats; D013203:Staphylococcal Infections / Q000188:drug therapy*; D014769:Virginiamycin / Q000008:administration & dosage* / Q000009:adverse effects; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D014769:Virginiamycin; C062940:quinupristin-dalfopristin
Apport des modèles expérimentaux: associations Synercid et beta-lactamines.