Recurrent immuno-allergic hepatitis related to amoxicillin-clavulanic acid.
We report on a patient who presented, on 2 occasions at one-year interval after a treatment with the amoxicillin-clavulanic acid association, a clinical and biological picture in keeping with the diagnosis of immuno-allergic hepatocellular hepatitis. On liver biopsies, the most characteristic finding was portal and lobular eosinophilic infiltration without cholestasis and biliary ducts damage.
Breuskin
F
F
Division of General Internal Medicine, Saint-Luc University Hospital Avenue, Hippocrate 10, B-1200 Brussels-Belgium.
Horsmans
Y
Y
Rahier
J
J
Lambert
M
M
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012008:Recurrence
D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination