title: Pemphigus foliaceus developing after metastasis of cutaneous squamous cell carcinoma to regional lymph nodes.
abstract: We describe a patient in whom pemphigus foliaceus developed after cutaneous squamous cell carcinoma (SCC) metastasized to regional lymph nodes. Immunologic analysis revealed that production of anti-desmoglein 1 autoantibodies started when SCC metastasized, and the SCC expressed desmoglein 1, suggesting a pathogenic role of metastasized SCC in developing pemphigus foliaceus.
authors.affiliation: Department of Dermatology, Kanazawa University School of Medicine, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8641, Japan. inaoki-m@med.kanazawa-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Inaoki
authors.forename: K
authors.initials: K
authors.lastname: Kaji
authors.forename: S
authors.initials: S
authors.lastname: Furuse
authors.forename: A
authors.initials: A
authors.lastname: Fujimoto
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
authors.forename: M
authors.initials: M
authors.lastname: Takata
authors.forename: K
authors.initials: K
authors.lastname: Takehara
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D015820:Cadherins / Q000032:analysis* / Q000096:biosynthesis; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D051183:Desmoglein 1; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D010392:Pemphigus / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D001323:Autoantibodies; D015820:Cadherins; D051183:Desmoglein 1