title: Autoimmune hepatitis associated with coagulation disorders and immunethyreopathy.
abstract: We present the case of a 42-year-old female patient with the diagnoses of autoimmune hepatitis type I and autoimmune thyroiditis. Furthermore this patient had an unusual combination of coagulation disorders with homozygous Factor V Leiden mutation (APC resistance) and presence of antiphospholipid antibodies, leading to deep vein thromboses and miscarriages. Only few cases with the combination of autoimmune hepatitis and antiphospholipid antibodies have been described and almost all of them had become symptomatic with the antiphospholipid syndrome. As both autoimmune phenomenons furthermore share similar HLA-patterns, their coincidence is probably not as uncommon as the limited number of case reports suggests. Therefore attention in patients with autoimmune hepatitis should be focused on thrombophilia.
authors.affiliation: Department of Gastroenterology-Heptaology, Hannover Medical School, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Benten
authors.forename: A
authors.initials: A
authors.lastname: Widjaja
authors.forename: M
authors.initials: M
authors.lastname: von Depka
authors.forename: P
authors.initials: P
authors.lastname: Flemming
authors.forename: C
authors.initials: C
authors.lastname: Trautwein
authors.forename: K
authors.initials: K
authors.lastname: Böker
authors.forename: A
authors.initials: A
authors.lastname: Vogel
authors.forename: J
authors.initials: J
authors.lastname: Rosenau
authors.forename: M P
authors.initials: MP
authors.lastname: Manns
mesh_terms: D020016:Activated Protein C Resistance / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D001706:Biopsy; D001780:Blood Coagulation Tests; D005165:Factor V / Q000235:genetics; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D006801:Humans; D008099:Liver / Q000473:pathology; D009154:Mutation; D019851:Thrombophilia / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology
chemical_list: C095381:factor V Leiden; D005165:Factor V