Fibroblasts in geriatric vocal fold mucosa.
Fifty fibroblasts in the macula flava (MF) and 50 fibroblasts in the Reinke's space (RS) of geriatric vocal folds were studied by transmission electron microscopy. Five larynges from autopsy cases in the age range 74-83 years were included in the study. The results were compared with those obtained previously from younger adults. The majority of fibroblasts in RS were spindle-shaped and those in MF were stellate. This was the case with younger adults. The nucleus/cytoplasm (N/C) ratio was 0.5-2.0 in most fibroblasts in RS and MF. Again, this was in common with the findings in younger adults. The development of rough endoplasmic reticulum (rER) and Golgi apparatus (GA) in MF was less marked in the geriatric group than in adults. Glycogen particles were observed in 28 fibroblasts in MF. Lipofuscin granules were found in 12 fibroblasts of RS and 9 cells of MF. The findings suggest a decrease in activities and the presence of ageing processes in fibroblasts of geriatric vocal fold mucosa, to which geriatric changes in the vocal ligament can be attributed.
Hirano
M
M
Department of Otolaryngology-Head and Neck Surgery, Kurume University, Japan.
Sato
K
K
Nakashima
T
T
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007820:Laryngeal Mucosa / Q000473:pathology*; D008062:Lipofuscin / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D012016:Reference Values; D014827:Vocal Cords / Q000473:pathology*
D008062:Lipofuscin; D006003:Glycogen