title: In vitro susceptibility of Coxiella burnetii to linezolid in comparison with its susceptibilities to quinolones, doxycycline, and clarithromycin.
abstract: The in vitro susceptibility to linezolid shown by nine Greek isolates of Coxiella burnetii derived from patients with acute Q fever was investigated. MICs of linezolid were compared with those of pefloxacin, ciprofloxacin, ofloxacin, trovafloxacin, doxycycline, and clarithromycin using the shell vial assay. MICs of linezolid and clarithromycin ranged from 2 to 4 microg/ml; those of doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 microg/ml; those of pefloxacin ranged from 1 to 4 microg/ml; and those of ciprofloxacin ranged from 4 to 8 microg/ml. Linezolid was effective in controlling intracellular parasites in cultures of Vero cells infected by C. burnetii. No bactericidal activity by linezolid was obtained against C. burnetii at 8 microg/ml.
authors.affiliation: Clinical Bacteriology, Parasitology, Zoonoses, and Geographical Medicine, Collaborating Center of WHO, University of Heraklion, 1352/71110 Crete, Greece. gikas@med.uoc.gr
authors.forename: A
authors.initials: A
authors.lastname: Gikas
authors.forename: I
authors.initials: I
authors.lastname: Spyridaki
authors.forename: E
authors.initials: E
authors.lastname: Scoulica
authors.forename: A
authors.initials: A
authors.lastname: Psaroulaki
authors.forename: Y
authors.initials: Y
authors.lastname: Tselentis
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D017291:Clarithromycin / Q000494:pharmacology*; D016997:Coxiella burnetii / Q000187:drug effects*; D004318:Doxycycline / Q000494:pharmacology*; D024841:Fluoroquinolones; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D011778:Q Fever / Q000382:microbiology; D014709:Vero Cells
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D023303:Oxazolidinones; D017291:Clarithromycin; D000069349:Linezolid; D004318:Doxycycline