Myositis in children.
Idiopathic inflammatory myositis in children includes multiple disease entities, but is primarily made up of juvenile dermatomyositis and, to a lesser degree, juvenile polymyositis. Much new information has been published in the last few years about these diseases, including the epidemiology, pathogenesis, clinical diagnosis, and outcomes and treatment. This includes information on onset of symptoms, potential inciting agents, and regional differences. Exciting data have emerged in our understanding of the immune response gene associations and the description of chimerism in children with these disorders. Finally, new advances in clinical evaluations and outcomes have been described as well as new treatment protocols to provide a more effective therapy with less toxicity. Continued investigation is needed to further understand these diseases, but great strides are being made in our understanding and ability to care for children with idiopathic inflammatory myositis.
Reed
A M
AM
Pediatrics, Mayo Clinic, Rochester, Minnesota 55905, USA. reed.ann18@Mayo.edu
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D009220:Myositis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy
D006680:HLA Antigens