title: [Changes in antidepressants consumption in the health area of Zamora from 1996 to 1999].
abstract: OBJECTIVE
  To describe the evolution of antidepressants outside hospital consumption (therapeutic subgroup N06A) in the health area of Zamora since 1996 to 1999, and also to rate the impact of the most recently marketed drugs introduction.
  
  
  METHODS
  Retrospective observational study.
  
  
  METHODS
  Primary care.
  
  
  METHODS
  All antidepressants containers dispensed in Zamora with prescription of the Seguridad Social in the 1996-1999 period are obtained from SIFAR (Pharmacy Management Informatic System), computing defined daily doses per 1000 inhabitants day (DHD) for each drug.
  
  
  RESULTS
  An increase of 47% in antidepressants whole consumption is observed, progressively since 1996 to 1999: 18.91 DHD (1996); 22.09 DHD (1997); 24.67 DHD (1998); 27.85 DHD (1999).ISRS (88%) and heterocyclics (56%) increase in this period, whereas IMAO (71%) and tricyclic antidepressants (14%) decrease.
  
  
  CONCLUSIONS
  Antidepressant whole consumption experiments an outstanding increase in the area of Zamora. Recently marketed drugs utilisation increases as well, superseding classical antidepressants. The five most used drugs in 1999 were, in decreasing order, paroxetine, fluoxetine, sertraline, citalopram and venlafaxine. These last three ones got the most outstanding rise in the reviewed period.
authors.affiliation: Gerencia de Atención Primaria de Zamora. Farmacéutico de Atención Primaria, 49007 Zamora. adiaz@gapza11.insalud.es
authors.forename: A
authors.initials: A
authors.lastname: Díaz Madero
authors.forename: A
authors.initials: A
authors.lastname: López Ferreras
authors.forename: M
authors.initials: M
authors.lastname: Ruiz-Clavijo Díez
authors.forename: M
authors.initials: M
authors.lastname: Vargas Aragón
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D004363:Drug Utilization / Q000706:statistics & numerical data; D006801:Humans; D012189:Retrospective Studies; D013030:Spain; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents
vernacular_title: Evolución del consumo de antidepresivos en el área de Zamora desde 1996 a 1999.