title: [Immunity and stress].
abstract: Changes occurring in stress response in the immune system and their effect upon resistance against infectious diseases, were studied. The main mechanisms of the stress induction involve: enhancement of the corticotropin-releasing factor and/or adrenocorticotropic hormone synthesis under the effect of interleukin-1; induced by an infection synthesis of the adrenocorticotropic hormone by lymphocytes, enhancement of the corticotropin-releasing factor synthesis under the effect of a psycho-emotional tension. The main reasons of decline in the immune-competence in stress, are discussed. Significance of stress-response as one of the mechanisms of the organism physiological response to extreme circumstances, is considered.
authors.affiliation: State Research Centre-Institute of Immunology, RF Ministry of Health, Russia, 115478, Moscow, Kashirskoe Shosse, 24, Korp. 2.
authors.forename: R M
authors.initials: RM
authors.lastname: Khaitov
authors.forename: V P
authors.initials: VP
authors.lastname: Leskov
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D001161:Arteriosclerosis / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D003348:Cortisone / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000378:metabolism / Q000473:pathology; D013312:Stress, Physiological / Q000276:immunology* / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology
chemical_list: D000324:Adrenocorticotropic Hormone; D003348:Cortisone
vernacular_title: Immunitet i stress.