title: Nonactin biosynthesis: disruption of the polyketide synthase genes, nonKJ, in Streptomyces griseus leads to an overall 96 decrease in macrotetrolide production, yet a net increase in nonactin analogues which incorporate isobutyrate.
authors.affiliation: Department of Chemistry The University of Montana, Missoula, Montana 59812-1656, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Walczak
authors.forename: M E
authors.initials: ME
authors.lastname: Nelson
authors.forename: N D
authors.initials: ND
authors.lastname: Priestley
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002087:Butyrates / Q000378:metabolism*; D058610:Isobutyrates; D018942:Macrolides / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000235:genetics*; D013237:Stereoisomerism; D013305:Streptomyces griseus / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002087:Butyrates; D058610:Isobutyrates; D018942:Macrolides; D009097:Multienzyme Complexes; C020380:isobutyric acid; C050476:nonactin