[Leukocyte glucocorticoid receptor and its mRNA levels in leukemia patients].
OBJECTIVE
To explore factors for differentiating non-Hodgkin's lymphoma cell leukemia (NHLCL) and acute lymphoblastic leukemia (ALL).


METHODS
Leukocyte glucocorticoid receptor (GR) and GR mRNA levels were measured in 22 NHLCL, 18 ALL, 10 chronic lymphocytic leukemia (CLL) patients and 6 healthy subjects by using radio-ligand binding assay and molecular hybridization using GR cDNA as the probe.


CONCLUSIONS
The leukocyte GR and GR mRNA levels were significantly different between NHLCL and ALL(P < 0.01), and could be used as parameters for differential diagnosis of these two types of leukemia.
Dong
Q
Q
Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433.
Meng
P
P
Min
B
B
D000328:Adult; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D011965:Receptors, Glucocorticoid / Q000032:analysis*
D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid