[Apoptosis of peripheral lymphocytes of healthy donors and patients with laryngeal neoplasms after gamma-irradiation in vitro].
Apoptosis in peripheral blood lymphocytes of healthy donors and cancer patients after gamma-irradiation with different doses was studied by the flow cytometry method. Wide intra- and interindividual variabilities of the lymphocyte radiosensitivity were observed. The radiosensitivity did not depend on the subpopulation composition of the lymphocyte pool. The persons with very low and high lymphocyte radiosensitivities were found significantly more often among the cancer patients than among the healthy donors. One can suggest that this method is useful as a biomarker of future cancer risk and prognosis of radiotherapy efficiency.
Orlova
N V
NV
Medical Radiological Research Center, Russian Academy of Sciences, Obninsk, 249020 Russia. mrrc@obninsk.ru
Smirnova
S G
SG
Zamulaeva
I A
IA
Andreev
V G
VG
Riabchenko
N I
NI
Saenko
A S
AS
D017209:Apoptosis / Q000528:radiation effects*; D001782:Blood Donors; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood / Q000473:pathology / Q000532:radiotherapy*; D008214:Lymphocytes / Q000473:pathology / Q000528:radiation effects*
Apoptoz limfotsitov perifericheskoĭ krovi zdorovykh donorov i bol'nykh rakom gortani posle vozdeĭstviia gamma-izlucheniia in vitro.