Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM.
An analytical method for the determination of N-nitrosodimethylamine (N-NDMA) in environmental aqueous samples has been developed using isotope dilution gas chromatography/mass spectrometry in the selected ion monitoring mode (GC/MS-SIM). After deuterated N-nitrosodimethylamine (d6-N-NDMA) as surrogate standard was added to the samples, the analytes were extracted with methylene chloride, dried with anhydrous sodium sulfate, and concentrated in a rotary evaporator. The concentrated extracts were analyzed by GC/MS-SIM after adding N-nitrosodiethylamine as an internal standard. The method detection limit for N-NDMA was 0.003 pg/microL and was validated by an analysis of a fortified water sample. The method was applied to real samples.
Raksit
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ENTECH-Agri-Service Laboratory, Inc., Research Development Section, Mississauga, ON, Canada.
Johri
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D002138:Calibration; D002852:Chromatography, Ion Exchange; D004128:Dimethylnitrosamine / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D007202:Indicators and Reagents; D012015:Reference Standards; D015203:Reproducibility of Results; D012996:Solutions; D014874:Water Pollutants, Chemical / Q000032:analysis*
D007202:Indicators and Reagents; D012996:Solutions; D014874:Water Pollutants, Chemical; D004128:Dimethylnitrosamine