[Phospholipase C negatively regulates tyrosine phosphorylation of EGF receptor in A-431 cells].
It is known that EGF induces tyrosine phosphorylation and internalization of the EGF receptor in A-431 cells. U73122, an inhibitor of phospholipase C, induces tyrosine phosphorylation of the EGF receptor and its association with phospholipase C still in nonstimulated cells. In U73122 treated cells EGF exerted no effect on these processes. Receptor-mediated endocytosis was not observed in A-431 cells treated with U73122. The reorganization of actin cytoskeleton was detected in U73122 cells.
Evdonin
A L
AL
Institute of Cytology RAS, St. Petersburg. evdonin@mail.ru
Leonov
A N
AN
Tsupkina
N V
NV
Medvedeva
N D
ND
D066246:ErbB Receptors / Q000378:metabolism*; D004963:Estrenes / Q000494:pharmacology; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D010766:Phosphorylation; D011760:Pyrrolidinones / Q000494:pharmacology; D015398:Signal Transduction; D014407:Tumor Cells, Cultured; D010738:Type C Phospholipases / Q000378:metabolism*; D014443:Tyrosine
D004963:Estrenes; D010726:Phosphodiesterase Inhibitors; D011760:Pyrrolidinones; C060229:1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; D014443:Tyrosine; D066246:ErbB Receptors; D010738:Type C Phospholipases
Fosfolipaza C negativno reguliruet fosforilirovanie po tirozinu retseptora EFR v kletkakh A-431.