title: [Surgery for non-colorectal and non-neuroendocrine liver metastases].
abstract: BACKGROUND
  Hepatic resection has been shown to prolong survival in selected patients with colorectal liver metastases. Due to slow tumor growth patients with neuroendocrine liver metastases tend to have a good prognosis and benefit from chemo-embolisation and symptomatic treatment. The role of surgery in treating non-neuroendocrine and non-colorectal liver metastases is discussed controversially, due to the limited knowledge on this subject. The aim of our study was, therefore, to evaluate our own experiences with hepatic surgery for non-neuroendocrine, non-colorectal liver metastases.
  
  
  METHODS
  A retrospective review of 72 patients (median age 60.9 years) who underwent 73 hepatic resections for non-neuroendocrine, non-colorectal liver metastases between 1980 and 2000 at a single tertial referral center was carried out.
  
  
  RESULTS
  Hepatic resection was combined with surgery for the primary tumor in 30 cases (41.1%). Hospital mortality was 4.2%. 35 patients (47.9%) developed complications. The mean hospital stay was 17.5 days. In 64.4% of the cases a potentially curative resection was reached. Overall actuarial survival was 52.1% at 1 year, 25.3% at 3 years and 9.9% at 5 years. The respective median overall survival times were 7.1 months (gastric cancer metastases; n = 15), 4.9 months (cholangiocellular cancer metastases; n = 9), 5.6 months (gall bladder, bile duct cancer metastases; n = 8), 35.4 months (kidney cancer metastases; n = 8), 14.4 months (breast cancer metastases; n = 4), 15.3 months (pancreas and other adenocarcinoma metastases; n = 11), 49.9 months (sarcoma metastases; n = 10) and 32.9 months (other metastases; n = 7).
  
  
  CONCLUSIONS
  In isolated hepatic metastases originating from sarcoma and hypernephroma radical resection can prolong survival. However, surgery cannot improve the prognosis in patients with liver metastases originating from the pancreas, gallbladder and the biliary tract. In selected patients with liver metastases from gastric and breast cancer long term survival seems possible after resection.
authors.affiliation: Klinische Abteilung für Allgemeinchirurgie, Klinische Abteilung für Transplantation, Universitätsklinik für Chirurgie, Universität Wien, Osterreich.
authors.forename: M
authors.initials: M
authors.lastname: Zacherl
authors.forename: F
authors.initials: F
authors.lastname: Längle
authors.forename: R
authors.initials: R
authors.lastname: Steininger
authors.forename: C
authors.initials: C
authors.lastname: Scheuba
authors.forename: E
authors.initials: E
authors.lastname: Wenzl
authors.forename: R
authors.initials: R
authors.lastname: Jakesz
authors.forename: J
authors.initials: J
authors.lastname: Zacherl
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary / Q000601:surgery; D002277:Carcinoma / Q000556:secondary / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods; D017052:Hospital Mortality; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008223:Lymphoma / Q000601:surgery; D008297:Male; D008545:Melanoma / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D012189:Retrospective Studies; D012509:Sarcoma / Q000556:secondary / Q000601:surgery; D016019:Survival Analysis; D016896:Treatment Outcome
vernacular_title: Die chirurgische Therapie von nicht-kolorektalen und nicht-neuroendokrinen Lebermetastasen.