title: [Expressions of cellular M-CSF and M-CSFR in hematopoietic cells].
abstract: OBJECTIVE
  To study the distribution of cellular M-CSF and its receptor in abnormal hematopoiesis.
  
  
  METHODS
  Six hematopoietic cell lines, 144 bone marrow (BM) and 160 peripheral blood (PB) samples were investigated with ABC immunoperoxidase assay.
  
  
  RESULTS
  Cellular M-CSF and/or M-CSFR were positive in all the 6 hematopoietic cell lines, a few normal BM(4 cases) and PB (32 cases) samples, hematological malignancies and a few benign hematological disorder samples. M-CSF and M-CSFR were found mainly in granulocytic lineage cells, seldom in erythroid and megakaryocytic lineage cells and never in lymphocytes. M-CSF and M-CSFR usually presented in cytoplasma and membrane and in some cases in nuclei.
  
  
  CONCLUSIONS
  Cellular M-CSF and M-CSFR is widely distributed in abnormal hematopoiesis, and is especially high in myeloid leukemias.
authors.affiliation: Institute of Hematology, CAMS, PUMC, Tianjin 300020.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Xue
authors.forename: Y
authors.initials: Y
authors.lastname: Song
mesh_terms: D018922:HL-60 Cells / Q000378:metabolism; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D020014:K562 Cells / Q000378:metabolism; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis*; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000096:biosynthesis*; D020298:U937 Cells / Q000378:metabolism
chemical_list: D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor