Transgenic plants as protein factories.
Transgenic plants are showing considerable potential for the economic production of proteins, with a few already being marketed. Recent clinical trials of pharmaceuticals produced from transgenic plants are encouraging, with plant glycans showing reassuringly poor immunogenicity. Our increasing understanding of protein targeting and accumulation should further improve the potential of this new technology.
Giddings
G
G
Institute of Biological Sciences, Cledwyn Building, University of Wales Aberystwyth, Aberystwyth, SY23 3DD, Ceredigion, UK. gdg@aber.ac.uk
D006031:Glycosylation; D007136:Immunoglobulins / Q000096:biosynthesis / Q000235:genetics; D007221:Industry; D010940:Plant Proteins / Q000096:biosynthesis / Q000235:genetics*; D030821:Plants, Genetically Modified / Q000235:genetics*; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000302:isolation & purification / Q000627:therapeutic use; D014612:Vaccines / Q000096:biosynthesis / Q000235:genetics
D007136:Immunoglobulins; D010940:Plant Proteins; D011994:Recombinant Proteins; D014612:Vaccines