title: The dilute locus and Griscelli syndrome: gateways towards a better understanding of melanosome transport.
abstract: In this review an overview of recent advances in the understanding of melanosome movement within epidermal melanocytes is given. Exploration of the molecular events involved in and determining the process of melanosome transport, as an essential part of human pigmentation, could lead to the identification of agents that augment, or down-regulate the transfer of melanosomes to surrounding keratinocytes. This would present a major breakthrough in the possibilities to influence pigmentation and related disorders, of great concern to some patients. Moreover, melanosome transport offers a good model to study mammalian organelle trafficking and its key players in general.
authors.affiliation: Department of Dermatology, Ghent University Hospital, Gent, Belgium.
authors.forename: W
authors.initials: W
authors.lastname: Westbroek
authors.forename: J
authors.initials: J
authors.lastname: Lambert
authors.forename: J M
authors.initials: JM
authors.lastname: Naeyaert
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D004398:Dyneins / Q000378:metabolism; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics*; D016547:Kinesins / Q000378:metabolism; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000166:cytology / Q000378:metabolism; D020460:Melanosomes / Q000378:metabolism*; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000235:genetics* / Q000378:metabolism; D024701:Myosin Type V / Q000235:genetics* / Q000378:metabolism; D010859:Pigmentation Disorders / Q000235:genetics*; D013577:Syndrome; D020691:rab GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D000075745:rab27 GTP-Binding Proteins
chemical_list: D008543:Melanins; D020409:Molecular Motor Proteins; D000075745:rab27 GTP-Binding Proteins; C077511:MYO5A protein, human; D024701:Myosin Type V; C066694:RAB27A protein, human; D018995:Myosin Heavy Chains; D004398:Dyneins; D016547:Kinesins; D020691:rab GTP-Binding Proteins