Ulcerative colitis after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.
A 54-year-old woman with peripheral T cell lymphoma in second complete remission (CR) received an autologous peripheral blood stem cell transplant (PBSCT). Antibiotic-resistant bloody diarrhea, and fever developed 110 days after transplant. Blood and stool cultures were negative. Skin rash was not observed. Barium enema and colonoscopy showed typical features of pancolonic-type ulcerative colitis (UC). Endoscopic biopsies confirmed the diagnosis of UC. Mesalazine and immunosuppressive therapy improved symptoms dramatically. We detected serum antibodies against synthetic tropomyosin (TM) peptide when UC was diagnosed. We postulate that autoimmunity including autoreactive anti-TM antibodies may be involved in the pathogenesis of UC after autologous PBSCT in this patient.
Koike
K
K
Department of Hematology, Japanese Red Cross Asahikawa Hospital, Asahikawa, Japan.
Kohda
K
K
Kuga
T
T
Nakazawa
O
O
Ando
M
M
Takayanagi
N
N
Matsunaga
T
T
Sakamaki
S
S
Niitsu
Y
Y
D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity / Q000276:immunology; D003093:Colitis, Ulcerative / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000628:therapy; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000628:therapy; D008875:Middle Aged; D014182:Transplantation, Autologous / Q000009:adverse effects; D014335:Tropomyosin / Q000276:immunology
D001323:Autoantibodies; D014335:Tropomyosin