[On control of radioactive-chemical protection and point mutations by inhibitors of free radical reactions].
An opportunity to control the DNA protection against radiation in cells and the formation of 2-desoxyribose residue epimers (sites of potential point mutations) by using a set of free radical scavengers differing by parameters of availability (molecular mask and access window) is discussed. The values of steric probability (efficiency) of formation of a chemical bond between atoms Cn of a 2-desoxyribosyl radical (n from 1 to 5) and H-atom of a scavenger donor group were determined. It was shown that the maximum effect of radioprotection determined, for example, by transformations of C2 radical reached 25% (4-oxy-3,5-di-tert-butyl-alpha-methylbenzylamine) and maximum yield of C4-epimer was 15.5% (L-cysteine).
Kuzurman
P A
PA
N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia.
Sharpatyĭ
V A
VA
D000818:Animals; D016166:Free Radical Scavengers; D005609:Free Radicals; D006801:Humans; D017354:Point Mutation; D011835:Radiation Protection
D016166:Free Radical Scavengers; D005609:Free Radicals
Ob upravlenii radiatsionno-khimicheskoĭ zashchitoĭ i obrazovaniem tochechnykh mutatsiĭ pri pomoshchi ingibitorov svobodnoradikal'nykh reaktsiĭ.