title: Uncertainty in particulate deposition for 1 microm AMAD particles in an adult lung model.
abstract: The ICRP 66 lung model may be used to determine dose estimates for members of the public via the inhalation pathway. A significant source of uncertainty in internal dosimetric modelling is due to particulate deposition in regions of the respiratory tract. Uncertainties in estimates of particulate deposition are present because model input parameters have their own inherent variability. These sources of uncertainty need to be examined in an effort to understand better model processes and to estimate better the doses received by individuals exposed through the inhalation pathway. An improved understanding of the uncertainty in particulate deposition will further guide research efforts and improve our ability to quantify internal dose estimates. The ICRP 66 lung deposition model is most sensitive to breathing rate when 1 microm AMAD particles are inhaled by members of the public. Uncertainties in deposition fractions are shown to span an order of magnitude with their distributions varying by gender for a particular lung region. The largest fractional deposition occurs in the deep lung alveolar and extrathoracic regions.
authors.affiliation: Department of Environmental Health Sciences, University of Michigan, Ann Arbor 48109, USA. harveyr@ne.orst.edu
authors.forename: R P
authors.initials: RP
authors.lastname: Harvey
authors.forename: D M
authors.initials: DM
authors.lastname: Hamby
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001980:Bronchi / Q000378:metabolism; D005260:Female; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D012137:Respiratory System / Q000378:metabolism*; D014018:Tissue Distribution; D014132:Trachea / Q000378:metabolism
chemical_list: D000336:Aerosols