Angiotensin I-converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome.
OBJECTIVE
To investigate the relationship of an insertion/deletion (I/D) polymorphism of the angiotension-converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS) patients and the control subjects.


METHODS
Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers flanked the polymorphic region in intro 16 of the ACE gene.


RESULTS
OSAS patients had significantly higher frequencies of I/I genotype and insertion allele of the ACE gene as compared with the control subjects in Chinese population. The OSAS patients with I/I genotype had significantly longer apnea time, lower minimum SaO2 and greater AHI than the OSAS patients with I/D genotype.


CONCLUSIONS
These results indicate that the I/I genotype and I allele are a risk factor for OSAS in Chinese.
Xiao
Y
Y
Department of Respiratory Disease, PUMC Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Huang
X
X
Qiu
C
C
Zhu
X
X
Liu
Y
Y
D000328:Adult; D000483:Alleles; D044466:Asian People; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D020181:Sleep Apnea, Obstructive / Q000235:genetics*
D007703:Peptidyl-Dipeptidase A