title: Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain.
abstract: Hundreds of millions of people now die over the age of 80 years primarily due to twentieth century progress in hygiene, chemotherapy, and immunology. With a longer average lifespan, the need to improve quality of life during the latter decades is more compelling. "Aging--The Epidemic of the New Millenium," a recent international conference (Monte Carlo, June 17-18, 2000), showed with peculiar clarity that a safe and efficient drug strategy to slow the age-related decay of brain performance is still missing. This review summarizes the physiologic and pharmacologic arguments in favor of a peculiar lifelong prophylactic medication with reasonable chances to keep in check brain aging and decrease the precipitation of age-related neurological diseases.
authors.affiliation: Department of Pharmacology, Faculty of General Medicine, Semmelweis University, H-1445 Budapest, Hungary. joszefknoll@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Knoll
mesh_terms: D000375:Aging / Q000187:drug effects*; D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010300:Parkinson Disease / Q000188:drug therapy; D011437:Propylamines / Q000494:pharmacology; D012642:Selegiline / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*
chemical_list: C404200:1-(benzofuran-2-yl)-2-propylaminopentane; D001572:Benzofurans; D002395:Catecholamines; D018696:Neuroprotective Agents; D011437:Propylamines; C068473:N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane; D012642:Selegiline; D012701:Serotonin