title: 188rhenium-TDD-lipiodol in treatment of inoperable primary hepatocellular carcinoma--a case report.
abstract: BACKGROUND
  The aim of this study was to investigate the potential of using 188Re Lipiodol for selective internal radiation therapy of inoperable hepatocellular carcinoma (HCC).
  
  
  METHODS
  A 33-year-old female with poorly-differentiated multicentric HCC, elevated alpha-fetoprotein (AFP) and increased serum alkaline phosphatase.
  
  
  METHODS
  Over a 2-month interval, the patient was treated twice with 4GBq of 188Re-TDD-Lipiodol.
  
  
  RESULTS
  There was good localisation of 188Re Lipiodol in the tumours, but also in thyroid (first treatment) and gastrointestinal tract (both treatments). So far (5 months post-treatment), the patient remains well with stable disease.
  
  
  CONCLUSIONS
  188Re Lipiodol can be an effective radiopharmaceutical for the treatment of HCC; however, more work must be done to minimise the uptake in bowel.
authors.affiliation: Department of Nuclear Medicine, Singapore General Hospital, 1 Hospital Drive, Singapore 169608. gnmfxs@sgh.com.sg
authors.forename: F X
authors.initials: FX
authors.lastname: Sundram
authors.forename: S W
authors.initials: SW
authors.lastname: Yu
authors.forename: J M
authors.initials: JM
authors.lastname: Jeong
authors.forename: S
authors.initials: S
authors.lastname: Somanesan
authors.forename: J
authors.initials: J
authors.lastname: Premaraj
authors.forename: M M
authors.initials: MM
authors.lastname: Saw
authors.forename: B S
authors.initials: BS
authors.lastname: Tan
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007459:Iodized Oil; D008113:Liver Neoplasms / Q000532:radiotherapy*; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000627:therapeutic use*; D011879:Radiotherapy Dosage
chemical_list: C431271:188Re 2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D007459:Iodized Oil