Successful pregnancy after high-dose cyclophosphamide, carboplatinum, and taxol with peripheral blood stem cell transplant in a young woman with ovarian carcinoma.
BACKGROUND
Both ovarian carcinoma and high-dose chemotherapy tend to preclude future pregnancies.


METHODS
We report a case of a young woman with borderline ovarian carcinoma and invasive tumor implants who underwent surgical debulking with preservation of future fertility followed by carboplatinum, paclitaxel (Taxol), and subsequent high-dose chemotherapy with subsequent peripheral blood stem cell rescue as part of a phase I clinical trial. After a brief period of amenorrhea, the patient had a successful pregnancy that was complicated by a spontaneous abortion in the first trimester. Several months later she conceived and delivered a healthy baby at term.


CONCLUSIONS
To our knowledge this is the first reported case of pregnancy after high-dose chemotherapy with stem cell transplant in a woman with ovarian carcinoma.
Seiden
M V
MV
Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. mseiden@partners.org
Spitzer
T R
TR
McAfee
S
S
Fuller
A F
AF
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D017321:Clinical Trials, Phase I as Topic; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic
D003520:Cyclophosphamide; D016190:Carboplatin; D017239:Paclitaxel