Edible genetically modified microorganisms and plants for improved health.
The development of new strategies for the delivery of vaccine antigens or immune modulators to the mucosal tissue includes innovative approaches such as the use of genetically modified food microorganisms and plants. Even though the 'proof-of-concept' has recently been established for these two systems, key questions mainly related to efficacy and risk of breaking oral tolerance remain to be critically addressed in the immediate future.
Mercenier
A
A
Laboratory of Bacteriology of Ecosystems, Institut Pasteur de Lille, 1 rue du Pr. Calmette, BP 245, F-59019 Cedex, Lille, France. annick.mercenier@ibl.fr
Wiedermann
U
U
Breiteneder
H
H
D000942:Antigens, Bacterial / Q000235:genetics; D000956:Antigens, Viral / Q000235:genetics; D001419:Bacteria / Q000235:genetics*; D005524:Food Technology; D005767:Gastrointestinal Diseases / Q000628:therapy; D006801:Humans; D018928:Immunity, Mucosal; D010945:Plants, Edible / Q000235:genetics*; D030821:Plants, Genetically Modified / Q000235:genetics*; D022462:Vaccines, Edible / Q000235:genetics*; D014765:Viral Vaccines / Q000235:genetics
D000942:Antigens, Bacterial; D000956:Antigens, Viral; D022462:Vaccines, Edible; D014765:Viral Vaccines