History of the Vessel Corkstopper for liquid medicines in Japan.
In this report it was found that in 1860, namely Gan-nen of Man-en in Japanese, cork caps were used for bottles of liver oil produced at fukuoka-han. On the other hand, it was previously proposed that the cork cap was first used for bottles of eye medicine, "Seikisui." This use occurred at least after 1867, namely the Third year of Keiou in Japanese. Therefore, it was clarified that the cork cap was used for liquid medicine in the form of a stopper for bottles of liver oil at least several years earlier than for "Seikisui."
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The Mushroom Research Institute in Japan.
D004349:Drug Packaging / Q000266:history*; D049672:History, 19th Century; D006801:Humans; D007564:Japan; D004364:Pharmaceutical Preparations / Q000266:history*
D004364:Pharmaceutical Preparations