title: Congenital choledochal cyst with pancreatitis.
abstract: OBJECTIVE
  To understand the relationship among congenital choledochal cyst, anomalous junction of pancreaticobiliary duct (AJPBD) and pancreatitis.
  
  
  METHODS
  25 children with choledochal cyst treated in our hospital were included in this study. Their ages ranged from 2 months to 14 years. Intraoperative cholangiography was performed in 24 children. Pancreatic samples obtained from the head and body of the pancreas at operation were observed under light and electron microscope. Serum amylase was analyzed one week before and after operation respectively. Bile amylase in the cyst and gallbladder was measured at operation.
  
  
  RESULTS
  The incidence of AJPBD was 70%. Inflammatory cell infiltration and fibrous hyperplasia were seen in the pancreatic specimens of 5 children, of whom 4 had AJPBD. No ultrastructural changes were found in 2 children without AJPBD, while different changes were seen in 6 with AJPBD, including those showing no pathological changes under light microscope. All the changes became more severe as the age of the patient increased. The bile and serum amylase levels were higher in children with AJPBD than those without AJPBD (P < 0.05).
  
  
  CONCLUSIONS
  Congenital choledochal cyst has a close relationship with AJPBD and pancreatitis. Pancreatic pathological changes have a long and chronic course from ultrastructural changes to macroscopic changes for the developing of pancreatitis.
authors.affiliation: Department of Pediatric Surgery, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China. pub@hbah.he.cninfo.net
authors.forename: L
authors.initials: L
authors.lastname: Zhao
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Ma
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Mou
authors.forename: D
authors.initials: D
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Lin
authors.forename: A
authors.initials: A
authors.lastname: Niu
mesh_terms: D000293:Adolescent; D017734:Bile Ducts, Extrahepatic / Q000002:abnormalities*; D002648:Child; D002675:Child, Preschool; D002758:Cholangiography; D015529:Choledochal Cyst; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010179:Pancreas / Q000648:ultrastructure; D010183:Pancreatic Ducts / Q000002:abnormalities*; D010195:Pancreatitis / Q000209:etiology / Q000473:pathology*