[Stem cells in adults].
BACKGROUND
We present a literature review of the plasticity observed by adult stem cells.


METHODS
We have reviewed the literature regarding stem cells from adults in order to summarise their ability to generate cells of other types than those of the tissue/organ from which they were isolated.


RESULTS
Adult stem cells have recently been demonstrated to terminally differentiate into cells of other tissues than those from which they were originally isolated. For example, bone marrow cells have been shown to generate liver, nerve, heart and skeletal muscle cells in addition to their well-known ability to produce blood and mesenchymal cells.


CONCLUSIONS
Most studies demonstrate a proof-of-principle in animal models; much more research is needed before adult stem cells can be utilised in human medicine. However, the published reports are encouraging and give reasons for a cautious optimism with regard to future clinical use.
Borge
O J
OJ
Avdeling for immunologi Det Norske Radiumhospital 0310 Oslo.
Funderud
S
S
D000328:Adult; D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism / Q000502:physiology; D002454:Cell Differentiation; D019976:Cloning, Organism; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology*
Stamceller hos voksne.