Expression of angiogenic factors in extrapelvic endometriosis.
The expression of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) were immunohistochemically examined in both pelvic and extrapelvic endometriotic lesions. Different expressions of VEGF and COX-2 were observed in both lesions. VEGF immunoreactivity was distributed mainly in the cytoplasm of the adenocytes in inguinal tumors, but was not seen in ovarian tumors. COX-2 showed the same findings. These results suggest that angiogenesis may be involved in the pathogenesis of extrapelvic endometriosis.
Deguchi
M
M
Department of Obstetrics and Gynecology, Osaka City General Hospital, Osaka 534-0021, Japan.
Ishiko
O
O
Sumi
T
T
Yoshida
H
H
Yamamoto
K
K
Ogita
S
S
D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D051546:Cyclooxygenase 2; D004715:Endometriosis / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D016228:Endothelial Growth Factors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007264:Inguinal Canal; D007527:Isoenzymes / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism*; D008565:Membrane Proteins; D009389:Neovascularization, Pathologic; D010048:Ovarian Cysts / Q000175:diagnosis / Q000473:pathology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D007527:Isoenzymes; D008222:Lymphokines; D008565:Membrane Proteins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases