title: Bacteremia in hospitalized patients with human immunodeficiency virus: A prospective, cohort study.
abstract: BACKGROUND
  Bacterial infections complicate the course of patients with human immunodeficiency virus infection. The purpose of this study was to describe the bacterial pathogens causing blood stream infection, identify the risk factors for the development of blood stream infection and determine the impact of blood stream infection on the outcome of patients infected with human immunodeficiency virus.
  
  
  METHODS
  The incidence, etiology, risk factors and outcome of bacterial blood stream infection were prospectively determined in 1,225 consecutive hospitalizations of adults with human immunodeficiency virus infection.
  
  
  RESULTS
  Blood stream infection occurred in 88 hospitalizations (7%); 73 of 89 infections (82%) were community acquired. The most commonly isolated gram-positive organism was Streptococcus pneumoniae (21); gram-negative, Escherichia coli (14). Blood stream infection was detected in 8% of African Americans and 22% of Hispanics compared with 2% of whites (P = 0.0013). Patients with blood stream infection had higher white blood cell counts (median, 6.5 vs. 4.9 x 109/L; P = 0.0002) and mortality (18% vs. 4%; P < 0.0001) than patients without infection.
  
  
  CONCLUSIONS
  In patients with human immunodeficiency virus, blood stream infection is associated with an increased mortality rate. Recognition of the incidence, etiology, and risk factors of blood stream infection in patients with human immunodeficiency virus infection could lead to measures that reduce the increased mortality.
authors.affiliation: Division of Pulmonary and Critical Care, University of Florida Health Science Center, Jacksonville, Florida, USA. afessa.bekele@mayo.edu
authors.forename: B
authors.initials: B
authors.lastname: Afessa
authors.forename: I
authors.initials: I
authors.lastname: Morales
authors.forename: B
authors.initials: B
authors.lastname: Weaver
mesh_terms: D000328:Adult; D000367:Age Factors; D016470:Bacteremia / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007902:Length of Stay; D008297:Male; D011446:Prospective Studies; D012737:Sex Factors