title: [Structural aspects of homeodomain interactions with DNA].
abstract: This review is devoted to the structural aspects of interaction of homeodomains with DNA. Presented are the list of all homeodomains with known spatial structure and the alignment of their amino acid sequences. The structure of homeodomains and contacts of their amino acid residues with DNA bases and sugar-phosphate backbone are described. The role of water molecules in DNA binding is discussed. Structures of multicomponent protein complexes on DNA including homeodomains are characterized.
authors.forename: R K
authors.initials: RK
authors.lastname: Ledneva
authors.forename: A V
authors.initials: AV
authors.lastname: Alekseevskiĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Vasil'ev
authors.forename: S A
authors.initials: SA
authors.lastname: Spirin
authors.forename: A S
authors.initials: AS
authors.lastname: Kariagina
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004247:DNA / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid
chemical_list: D018398:Homeodomain Proteins; D004247:DNA
vernacular_title: Strukturnye aspekty vzaimodeĭstviia gomeodomenov s DNK.