title: Surgical treatment of HELLP syndrome-associated liver rupture -- an update.
abstract: In some 2% of the cases of the HELLP syndrome, severe spontaneous bleeding into the liver accompanied by haemorrhagic liver cell necrosis and rupture of the organ occurs and represents one of the main cause of death. On the basis of our own experience with four cases, a review of the literature is presented with particular focus on a therapeutic concept based on appropriate surgery. Within a MEDLINE search covering the period 1990-1999, the case reports of this kind of liver complication in the literature were analysed in terms of clinical course and outcome.In addition to our own four patients, a total of 49 cases with rupture of the liver were found in the literature. Despite surgical interventions, HELLP syndrome-associated liver rupture carried a mortality of 39%. Most patients died of haemorrhagic shock and organ failure. In order to improve survival, patients with ruptured liver or hepatic failure should be transferred to a centre with the necessary experience in liver surgery including liver transplantation. An interdisciplinary approach is required, including the use of temporary packing of the liver to control the bleeding, and during the further course of the condition, possibly even liver transplantation, as in one of our own cases.
authors.affiliation: Department of Surgery, Chirurgische Universitätsklinik, Erlangen-Nürnberg, Krankenhausstr. 12, D-91054 Erlangen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Reck
authors.forename: M
authors.initials: M
authors.lastname: Bussenius-Kammerer
authors.forename: R
authors.initials: R
authors.lastname: Ott
authors.forename: V
authors.initials: V
authors.lastname: Müller
authors.forename: E
authors.initials: E
authors.lastname: Beinder
authors.forename: W
authors.initials: W
authors.lastname: Hohenberger
mesh_terms: D000328:Adult; D005260:Female; D017359:HELLP Syndrome / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D008099:Liver / Q000293:injuries*; D016031:Liver Transplantation; D011247:Pregnancy