title: Expression of angiogenic factors in extrapelvic endometriosis.
abstract: The expression of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) were immunohistochemically examined in both pelvic and extrapelvic endometriotic lesions. Different expressions of VEGF and COX-2 were observed in both lesions. VEGF immunoreactivity was distributed mainly in the cytoplasm of the adenocytes in inguinal tumors, but was not seen in ovarian tumors. COX-2 showed the same findings. These results suggest that angiogenesis may be involved in the pathogenesis of extrapelvic endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City General Hospital, Osaka 534-0021, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Deguchi
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: T
authors.initials: T
authors.lastname: Sumi
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D051546:Cyclooxygenase 2; D004715:Endometriosis / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D016228:Endothelial Growth Factors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007264:Inguinal Canal; D007527:Isoenzymes / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism*; D008565:Membrane Proteins; D009389:Neovascularization, Pathologic; D010048:Ovarian Cysts / Q000175:diagnosis / Q000473:pathology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D007527:Isoenzymes; D008222:Lymphokines; D008565:Membrane Proteins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases