Elevated substance P levels in HIV-infected men.
The neuropeptide, substance P, is a potent modulator of neuroimmunoregulation. Substance P and its receptor modulate HIV infection. HIV-seropositive men had significantly higher plasma substance P levels compared with uninfected controls, which were associated with decreased CD16 and CD56 natural killer (NK) cell populations. The changes in plasma substance P levels and decreases in NK subsets did not correlate with CD4 cell levels, but a diurnal pattern was suggested for substance P. The balance between substance P expression and functions of immune cells may be important in the immunopathogenesis of HIV infection.
Douglas
S D
SD
Section of Immunology, Division of Immunologic and Infectious Diseases, The Joseph Stokes Jr Research Institute, The Children's Hospital of Philadelphia, PA, USA.
Ho
W Z
WZ
Gettes
D R
DR
Cnaan
A
A
Zhao
H
H
Leserman
J
J
Petitto
J M
JM
Golden
R N
RN
Evans
D L
DL
D015331:Cohort Studies; D005434:Flow Cytometry; D015658:HIV Infections / Q000097:blood* / Q000276:immunology; D018023:HIV Seronegativity; D006716:Homosexuality; D006801:Humans; D007694:Killer Cells, Natural; D008297:Male; D013373:Substance P / Q000097:blood*
D013373:Substance P