Interaction of isotretinoin with endogenous retinoids.
Isotretinoin exhibits antiproliferative and antiandrogenic effects on the sebaceous glands by yet unknown mechanisms. This review focuses on a putative mechanism of action of isotretinoin involving the interaction of isotretinoin with the metabolism of endogenous retinoids and androgens.
Törmä
H
H
Department of Medical Sciences, Section of Dermatology and Venereology, University Hospital, SE-751 85 Uppsala, Sweden. hans.torma@med-sci.uu.se
D000152:Acne Vulgaris / Q000188:drug therapy; D000728:Androgens / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D003879:Dermatologic Agents / Q000494:pharmacology*; D006801:Humans; D015474:Isotretinoin / Q000494:pharmacology*; D012176:Retinoids / Q000494:pharmacology*; D012627:Sebaceous Glands / Q000187:drug effects*
D000728:Androgens; D003879:Dermatologic Agents; D012176:Retinoids; D015474:Isotretinoin