title: Meta-analysis of functional outcome in Parkinson patients treated with unilateral pallidotomy.
abstract: Parkinson's disease (PD) profoundly affects activities of daily living (ADL) and quality of human life. Although unilateral pallidotomy has become a common surgical treatment for persons with advanced PD, functional outcome data from previous reports have failed to uniformly support this procedure. In the present investigation, results from 12 studies meeting specific inclusion criteria were subjected to meta-analysis. Only reports featuring unilateral pallidotomy as the exclusive surgery, a sample size of at least five patients, explicit assessment of ADL, and sufficient quantitative data were subjected to analysis. Type of research design was not a factor in the selection process. The results of our analysis suggest that unilateral pallidotomy successfully enhances functional outcome in patients with clinically advanced PD.
authors.affiliation: Department of Occupational Therapy, School of Pharmacy and Allied Health Professions, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA. sahmad@creighton.edu
authors.forename: S O
authors.initials: SO
authors.lastname: Ahmad
authors.forename: K
authors.initials: K
authors.lastname: Mu
authors.forename: S A
authors.initials: SA
authors.lastname: Scott
mesh_terms: D000203:Activities of Daily Living; D007839:Functional Laterality / Q000502:physiology; D005917:Globus Pallidus / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D011788:Quality of Life; D020127:Recovery of Function / Q000502:physiology*; D016896:Treatment Outcome