title: [Studies on Fugu (globefish) tetrodotoxin over one century].
abstract: One century has passed since fugu toxin was first named tetrodotoxin by Tahara. Chemical problems such as crystallization of tetrodotoxin, followed by structure determination by the research groups headed by Tsuda, Hirata, Woodward, and Mosher, and its subsequent synthesis by Kishi have been solved. In the last 10 years, research on the distribution of tetrodotoxin in nature has shown that tetrodotoxin is not produced by fugu fish, but rather is formed by sea bacteria such as Vibrio, Alteromonas, Photobacterium, and Aeomonas. However, it remains unclear why tetrodotoxin accumulates at a high concentration only in fugu.
authors.affiliation: Kyushu Women's University.
authors.forename: K
authors.initials: K
authors.lastname: Sakai
mesh_terms: D000818:Animals; D005399:Fishes; D049672:History, 19th Century; D049673:History, 20th Century; D007564:Japan; D013779:Tetrodotoxin / Q000266:history*
chemical_list: D013779:Tetrodotoxin