[Calcium ions and the nervous system plasticity].
The nervous system is different from all other systems of the organism by extreme flexibility of the structural and functional properties of its elements. This unique feature of the nervous system can be best described as plasticity in a broad sense of the word. All forms of plastic changes in the nervous system functioning have common basic mechanisms, the changes at the free Ca2+ cytosol ions being the most important one. These "calcium signals" trigger an extremely complicated intracellular machinery capable of controlling the structural and functional properties of the nervous system during the whole life span. This review summarises data on the intracellular Ca2+ ions mechanisms controlling the developmental plasticity of neuronal elements, synaptic plasticity of the mature nervous system, and the decline of plastic capabilities with ageing.
Kostiuk
P G
PG
Bogomoletz Institute of Physiology, Ukraine, 252024, Kiev, Bogomoletz St., 4.
D000375:Aging / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D009415:Nerve Net / Q000502:physiology; D009424:Nervous System Physiological Phenomena; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000502:physiology
D002118:Calcium
Iony kal'tsiia i plastichnost' nervnoĭ sistemy.