[Assessing the informative value of positron emission tomography with the new radiopharmaceutical Sodium 11C-butyrate versus small-dose dobutamine stress echocardiography in the diagnosis of myocardial viability in patients with coronary heart disease and left ventricular dysfunction].
Myocardial viability in patients with coronary artery disease and heart failure was assessed by echocardiography with low doses of dobutamine and positron emission tomography with Sodium 11C-butyrate. Sensitivity and specificity of those methods were compared. Positron emission tomography and Sodium 11C-butyrate had quite high sensitivity and specificity, which could be compared with positron emission tomography and fluorine-18-deoxyglucose. Echocardiography with low doses of dobutamine had high specificity and its sensitivity was lower that one of positron emission tomography and Sodium 11C-butyrate. Thus, it is necessary to use the protocol of stress dobutamine echocardiography with high doses to avoid this problem.
Ryzhkova
D
D
Central Research Institute of X-ray and Radiation Studies, Ministry of Health, Russian Federation, I. P. Pavlov Saint Petersburg State Medical University.
Tiutin
L
L
Kostenikov
N
N
Nifontov
E
E
Shliakhto
E
E
Savello
V
V
Rudomanov
O
O
Zakharov
D
D
Kazarin
V
V
D000328:Adult; D000368:Aged; D002087:Butyrates / Q000493:pharmacokinetics; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D002316:Cardiotonic Agents; D003327:Coronary Disease / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D004280:Dobutamine; D025401:Echocardiography, Stress; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology
D002087:Butyrates; D002250:Carbon Radioisotopes; D002316:Cardiotonic Agents; D004280:Dobutamine
Sravnitel'naia otsenka informativnisti positronnoi emissionnoi tomografii s nov"m radiofarmpreparatom 11S-butiratom natriia i stress-ekhocardiografii s malymi dozami dobutamina v diagnostike zhiznecposobnosti miokarda u bol'nykh ishemicheskoi bolezn'iu serdtsa s disfunktsiei levogo zheludochka