[Effect of yuanhua on isolated uterine strips in unpregnant rats].
OBJECTIVE
To explore the mechanism on the effect of Yuanhua on the contractile activity of isolated uterine strips in rats under artificial oestrum.


METHODS
Isolated strips were suspended in a tissue chamber in which Yuanhua was added with some antagonists of inhibitors or without.


RESULTS
Yuanhua could excite the uterine smooth muscle strips in a dose-dependent manner, but atropine, phentolamine, hexamethonium and diphenhydramine could not inhibit this exciting action. This exciting effect could be inhibited completely by verapamil and decreased by indomethacin(inhibitor of prostaglandin synthase).


CONCLUSIONS
The exciting effect of Yuanhua on un-pregnant rats in vitro might be related to an action on the cell membrane Ca2+ channel as well as to a partial stimulation of synthesis and release of PG.
Ma
Y
Y
Department of Physiology, Lanzhou Medical College, Lanzhou 730000.
Liu
H
H
Qu
S
S
Qiu
X
X
Zhang
Y
Y
Ding
Y
Y
Wei
Y
Y
D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D019684:Magnoliopsida; D009130:Muscle, Smooth / Q000187:drug effects*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D016861:Cyclooxygenase Inhibitors; D004365:Drugs, Chinese Herbal; D014700:Verapamil; D007213:Indomethacin