title: Primary adenocarcinoma of the vagina arising in endocervicosis.
abstract: Endocervicosis is a rare condition, being one of the triad of non-neoplastic secondary mullerian lesions. This report describes a primary vaginal adenocarcinoma arising in endocervicosis. Histologic examination showed a mucin-secreting adenocarcinoma admixed with benign mucin-containing endocervical-type glands with a transition from dysplastic glands to obvious adenocarcinoma. There were bilateral groin lymph node metastases at presentation and the tumor recurred locally 9 and 12 months after treatment. This is the second reported case of vaginal endocervicosis and the first documented report of adenocarcinoma arising in endocervicosis at any site.
authors.affiliation: Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BL, Northern Ireland. glenn.mccluggage@bll.n-i.nhs.uk
authors.forename: W G
authors.initials: WG
authors.lastname: McCluggage
authors.forename: J H
authors.initials: JH
authors.lastname: Price
authors.forename: S P
authors.initials: SP
authors.lastname: Dobbs
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D001706:Biopsy; D018394:CA-125 Antigen / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002584:Cervix Uteri / Q000473:pathology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D008197:Lymph Node Excision; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009077:Mucins / Q000032:analysis / Q000378:metabolism; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014625:Vaginal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D014626:Vaginal Smears
chemical_list: D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D009077:Mucins; D007633:Keratins