Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites.
Studies on the control of eukaryotic translation initiation by a cap-independent recruitment of the 40S ribosomal subunit to internal messenger RNA sequences called internal ribosome entry sites (IRESs) have shown that these sequence elements are present in a growing list of viral and cellular RNAs. Here we discuss their prevalence, mechanisms whereby they may function and their uses in regulating gene expression.
Vagner
S
S
INSERM U397, Institut Louis Bugnard, CHU Rangueil, 31403 Toulouse, France.
Galy
B
B
Pyronnet
S
S
D020121:5' Untranslated Regions; D000818:Animals; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D014176:Protein Biosynthesis; D012313:RNA / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*
D020121:5' Untranslated Regions; D012333:RNA, Messenger; D012313:RNA