title: Improvement of the synthesis of diphenylmethyl 7beta-(o-hydroxy)benzylideneamino-3-hydroxymethyl-3-cephem-4-carboxylate.
abstract: The title product (I) is synthesized currently from 7-aminocephalosporanic acid, and diphenyldiazomethane (DDM) is used as a protective reagent of the acid function for further reactions. When DDM was prepared from benzophenone hydrazone by reaction with chloramine T, it was resulted impure by p-toluenesulfonamide, formed as side product, which cannot be removed during the final purification step carried out according to the literature procedure. Two simple methods are proposed here to obtain I with the suitable degree of purity necessary for a drug.
authors.affiliation: Centro de Quimica Farmaceutica (CQF), Ciudad de La Habana, Cuba.
authors.forename: M
authors.initials: M
authors.lastname: López
authors.forename: Z
authors.initials: Z
authors.lastname: Rodríguez
authors.forename: B
authors.initials: B
authors.lastname: Valdés
authors.forename: H
authors.initials: H
authors.lastname: Velez
authors.forename: J
authors.initials: J
authors.lastname: Agüero
authors.forename: A
authors.initials: A
authors.lastname: Fini
authors.forename: M
authors.initials: M
authors.lastname: González
mesh_terms: D001554:Benzene / Q000138:chemical synthesis*; D001555:Benzene Derivatives; D001559:Benzhydryl Compounds / Q000138:chemical synthesis*
chemical_list: D001555:Benzene Derivatives; D001559:Benzhydryl Compounds; C449754:diphenylmethyl 7-(o-hydroxy)benzylideneamino-3-hydroxymethyl-3-cephem-4-carboxylate; D001554:Benzene