title: George III: a revised view of the royal malady.
abstract: George III of England's episodic psychotic illness is described. The data has previously been used to substantiate the diagnosis of an unlikely hereditary metabolic disease, porphyria. A scientific perspective, aimed at removing psychiatric diagnosis from dependence on subjective evaluations, is corrected by the diagnosis of a mood disorder. His unipolar mania of late onset is a syndrome, the sine qua non of bipolar disorder, in this instance complicated by the toxicity of quinine, antimony, and purgatives.
authors.affiliation: Harlem Hospital Center, New York, 10037, USA.
authors.forename: S
authors.initials: S
authors.lastname: Brownstein
mesh_terms: D001714:Bipolar Disorder / Q000266:history*; D005197:Famous Persons; D049671:History, 18th Century; D006801:Humans; D011164:Porphyrias / Q000266:history*; D006113:United Kingdom