[Hyperbaric oxygen inhibits neutrophil infiltration and reduces postischemic brain injury in rats].
Reversible occlusion of the middle cerebral artery (MCA) was used to test hypothesis that hyperbaric oxygen inhibits the neutrophile infiltration into the ischemic brain thus reducing the brain injury. Treatment with hyperbaric oxygen prior to ischemia or during MCA occlusion significantly reduced neutrophile infiltration, motor disorders, and cerebral infarction volume.
Atochin
D N
DN
M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., Russia, 194223, St. Petersburg, pr. M. Toreza, 44.
Fisher
D
D
Thom
S R
SR
Demchenko
I T
IT
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications; D020520:Brain Infarction / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D006931:Hyperbaric Oxygenation; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D008297:Male; D020768:Middle Cerebral Artery; D009504:Neutrophils / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
Giperbaricheskiĭ kislorod ingibiruet infil'tratsiiu neĭtrofilov i oslabliaet postishemicheskoe porazhenie mozga u krys.