Improvement of the synthesis of diphenylmethyl 7beta-(o-hydroxy)benzylideneamino-3-hydroxymethyl-3-cephem-4-carboxylate.
The title product (I) is synthesized currently from 7-aminocephalosporanic acid, and diphenyldiazomethane (DDM) is used as a protective reagent of the acid function for further reactions. When DDM was prepared from benzophenone hydrazone by reaction with chloramine T, it was resulted impure by p-toluenesulfonamide, formed as side product, which cannot be removed during the final purification step carried out according to the literature procedure. Two simple methods are proposed here to obtain I with the suitable degree of purity necessary for a drug.
López
M
M
Centro de Quimica Farmaceutica (CQF), Ciudad de La Habana, Cuba.
Rodríguez
Z
Z
Valdés
B
B
Velez
H
H
Agüero
J
J
Fini
A
A
González
M
M
D001554:Benzene / Q000138:chemical synthesis*; D001555:Benzene Derivatives; D001559:Benzhydryl Compounds / Q000138:chemical synthesis*
D001555:Benzene Derivatives; D001559:Benzhydryl Compounds; C449754:diphenylmethyl 7-(o-hydroxy)benzylideneamino-3-hydroxymethyl-3-cephem-4-carboxylate; D001554:Benzene