[The value of 99mTc-sulfer colloid bone marrow scintigraphy in differential diagnosis of aplastic anemia].
OBJECTIVE
To diagnose equivocal aplastic anemia(AA) patients by the combination of clinical data and bone marrow scintigraphy.


METHODS
Bone marrow scintigraphy using 99mTc-sulfer colloid 370-550 MBq was analysed in 47 patients, including 28 cases of AA, 12 of myelodysplastic syndromes(10 MDS-RA and 2 MDS-RAEB) and 7 of AA-PNH syndrome.


RESULTS
Pancytopenia, hypercellular bone marrow associated with uneven disappearance of marrow image or focal hematopoiesis were found in 28 AA and 2 of 30 MDS-RA cases. Marrow imaging showed uneven low accumulation of radioactivity in 12 and focal patterns in 18 patients. Normal or high activity and expanded periphery of bone marrow was found in MDS patients (8 RA and 2 RAEB cases). Changes of activity and distribution of bone marrow during the transforming course were noticed in 4 AA-PNH syndrome patients.


CONCLUSIONS
Patch distribution and focal hemopoiesis is the outstanding features of AA marrow. The imaging features as well as expanded manner and increased activity of bone marrow are helpful to the differential diagnosis, evaluation of clinical status and explanation of marrow aspirate results.
Liu
Y
Y
Shandong Medical University, Jinan 250012.
Jia
F
F
Li
M
M
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000000981:diagnostic imaging*; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid
D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid