[Pathogenetic effect of platelet activating factor on enterogenic endotoxemia after burn].
OBJECTIVE
To investigate the effects of platelet activating factor (PAF) on the occurrence of enterogenic endotoxemia after burn.


METHODS
The relationship between changes of PAF and enterogenic endotoxima was observed on a model of rats with 30% TBSA III degree burn.


RESULTS
The intestinal permeability and plasma endotoxin were significantly elevated and were positively correlated with the increase of PAF in the intestinal tissue and blood. PAF antagonist treatment significantly decreased the intestinal permeability and the levels of plasma endotoxin. After intravenous injection of enogenous PAF to healthy rats, the intestinal permeability and plasma endotoxin were also markedly increased, which was significantly depended on the dose of PAF.


CONCLUSIONS
PAF is one of the important factors for the occurrence of postburn enterogenic endotoximia.
Yu
P
P
Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038.
Xiao
G
G
Fu
W
W
D000818:Animals; D002056:Burns / Q000150:complications* / Q000378:metabolism; D019446:Endotoxemia / Q000209:etiology* / Q000378:metabolism; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D010539:Permeability / Q000187:drug effects; D010972:Platelet Activating Factor / Q000378:metabolism* / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D010972:Platelet Activating Factor