[The effects of 6A8 cDNA transfection on biological behavior of tumor cells].
OBJECTIVE
To investigate the effects of antisense 6A8 cDNA on the malignant behavior of tumor.


METHODS
Highly metastatic clonal variant CNE-2L2 from nasopharygeal carcinoma cell line(CNE-2Z) was transfected with antisense 6A8 cDNA or mock plasmid. Their adhesion, locomotion, proteolytic ability, in vitro invasion, in vivo growth and metastasis were comparatively studied with the wild CNE-2L2 cells.


RESULTS
Antisense 6A8 cDNA transfected CNE-2L2 showed less adhesion to FN and LN, weakened locomotive ability and proteolytic ability, retarded in vivo growth and much less metastasis.


CONCLUSIONS
Transfection of antisense 6A8 cDNA obviously decreased the malignant behavior of tumor cells.
Liu
Y
Y
Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005.
Zhang
L
L
Gu
P
P
D002448:Cell Adhesion; D016373:DNA, Antisense / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics*; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*; D014162:Transfection; D014407:Tumor Cells, Cultured
D016373:DNA, Antisense; D018076:DNA, Complementary