title: [Increase of water permeability and recovery of water impermeability of the frog urinary bladder].
abstract: The experiments carried out on the urinary bladder of the frog Rana temporaria L. have shown that the period of recovery of water impermeability after an increase of osmotic water permeability induced by arginine-vasotocin, desmopressin, or cAMP depends on the degree of increase of the osmotic permeability but not on the nature of the substance stimulating the increase of osmotic water permeability. The removal of the hormone in the absence of autacoids fails to recover the water impermeability. After cessation of the vasotocin action the water permeability decrease is delayed if phospholipase A2 and cyclooxygenase are inhibited by qiunacrine and voltaren, respectively. An agonist of V1-receptors has no effect on dynamics of the recovery of water impermeability. This recovery has been shown to depend on PGE2 concentration in the serosal solution after the hormone removal. The obtained results indicate that decrease of water permeability depends not only on removal of vasotocin or cAMP but also on involvement of autacoids.
authors.affiliation: M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., Russia, 194223, St. Petersburg, Thorez Av., 44, Russia.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Natochin
authors.forename: N P
authors.initials: NP
authors.lastname: Prutskova
authors.forename: E I
authors.initials: EI
authors.lastname: Shakhmatova
mesh_terms: D000818:Animals; D001692:Biological Transport; D000242:Cyclic AMP / Q000494:pharmacology; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D009995:Osmosis; D010539:Permeability; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D011796:Quinacrine / Q000494:pharmacology; D011896:Rana temporaria; D017483:Receptors, Vasopressin / Q000819:agonists; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism*; D014668:Vasotocin / Q000494:pharmacology; D014867:Water
chemical_list: D004791:Enzyme Inhibitors; D017483:Receptors, Vasopressin; D014867:Water; D004008:Diclofenac; D000242:Cyclic AMP; D010741:Phospholipases A; D054467:Phospholipases A2; D003894:Deamino Arginine Vasopressin; D011796:Quinacrine; D015232:Dinoprostone; D014668:Vasotocin
vernacular_title: Dinamika uvelicheniia osmoticheskoĭ pronitsaemosti i vosstanovleniia vodonepronitsaemosti mochevogo puzyria liagushki.