[Genomic organization and chromosomal localization of a new repeat MS7, specific for heterochromatin of sex chromosomes in Microtus species voles of the arvalis group].
The tandemly arranged MS4 repeat with monomeric units of 4.1 kb is species-specifically distributed in heterochromatin of sex chromosomes of four common vole species of genus Microtus, group arvalis [1, 2]. In this work, we studied the genomic organization of the MS4 homolog in euchromatin of the X chromosome of M. arvalis. It has been shown by analyzing the phage genomic clones that one MS4 copy makes a part of a monomeric unit exceeding 8.5 kb that also includes a new MS7 repeat and, possibly, LINE fragments. MS7 is located together with MS4 in heterochromatin of common vole sex chromosomes, but in a substantially lesser amount. Probably, as a result of an evolutionary transition of an original repeat from euchromatin of the X chromosome to heterochromatin of the Y chromosome, MS4 underwent multiple amplification, and MS7 spread throughout heterochromatin, being surrounded by the MS4 tandem arrays.
Kozlova
S V
SV
Elisafenko
E A
EA
Mazurok
N A
NA
Zakiian SM
D000818:Animals; D003411:Arvicolinae / Q000235:genetics*; D002874:Chromosome Mapping; D016678:Genome; D006570:Heterochromatin / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D014960:X Chromosome; D014998:Y Chromosome
D006570:Heterochromatin
Genomnaia organizatsiia i khoromosomnaia lokalizatsiia novogo povtora MS7, spetsifichnogo dlia geterokhromatina polovykh khromosom u polevok roda Microtus gruppy arvalis.