Primary peritoneal clear cell carcinoma: excellent results from paclitaxel and carboplatin combination chemotherapy.
While papillary serous adenocarcinomas are histocytologically common in primary peritoneal carcinomas, clear cell carcinomas are rare. We report a new regimen for the treatment of recurrent clear cell carcinomas of the peritoneum. A 45-year-old woman was referred to our hospital and underwent optimal debulking surgery. Thirty-two months after the operation, lymph node swelling and elevation of serum CA19-9 were detected and recurrence was diagnosed. Paclitaxel (175 mg/m(2)) in a 3-hour and carboplatin (300 mg/m(2)) in a 1-hour infusion were repeated at three-week intervals. After completion of four courses, abdominal CT and serum CA19-9 were undertaken and results compared. Lymph node swelling was significantly decreased and the serum CA19-9 level was decreased to within a normal range. Paclitaxel and carboplatin combination chemotherapy may be effective in preventing the recurrence of peritoneal carcinomas.
Ichimura
T
T
Department of Obstetrics and Gynecology, Sumitomo Hospital, Kita-ku, Osaka 530-0005, Japan. ichimura-tomoyuki@sumitomo-hp.or.jp
Ishiko
O
O
Nishimura
S
S
Kojima
T
T
Shimura
K
K
D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*
D016190:Carboplatin; D017239:Paclitaxel