In vitro and in vivo activities of sitafloxacin against Chlamydia spp.
The in vitro and in vivo antichlamydial activity of sitafloxacin was investigated. The MICs and minimal chlamydiacidal concentrations of sitafloxacin for various species of chlamydia ranged from 0.031 to 0.125 microg/ml. Sitafloxacin had an excellent therapeutic effect on experimental Chlamydia psittaci pneumonia and was more potent than tosufloxacin, ofloxacin, and ciproflxacin, although slightly less potent than sparfloxacin.
Miyashita
N
N
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan. nao@med.kawasaki-m.ac.jp
Niki
Y
Y
Matsushima
T
T
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002689:Chlamydia / Q000187:drug effects*; D002690:Chlamydia Infections / Q000382:microbiology; D024841:Fluoroquinolones; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C076246:sitafloxacin; D015242:Ofloxacin