Plexin signaling via off-track and rho family GTPases.
Two papers in this issue of Neuron examine new aspects of Semaphorin signaling via Plexin receptors. Winberg et al. present evidence that the transmembrane protein Off-track (OTK) interacts biochemically and genetically with Plexin A and is important for Sema 1a repulsive signaling. Hu et al. examine the coupling of Plexin B to Rac and RhoA and propose that Plexin B signaling involves inhibition of Rac function by direct sequestration and simultaneous activation of RhoA.
Whitford
K L
KL
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ghosh
A
A
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D029721:Drosophila Proteins; D008565:Membrane Proteins / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D011505:Protein-Tyrosine Kinases; D017468:Receptors, Fibroblast Growth Factor; D015398:Signal Transduction / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000502:physiology*
D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D017468:Receptors, Fibroblast Growth Factor; C091529:plexin; D011505:Protein-Tyrosine Kinases; C102667:htl protein, Drosophila; D020741:rho GTP-Binding Proteins