Kidney preservation with university of Wisconsin and Celsior solution: a prospective multicenter randomized study.
BACKGROUND
Although the University of Wisconsin (U.W.) solution continues to be the most commonly used for intra-abdominal organs, a new solution, Celsior, already used for heart and lungs, has been proposed for kidney and liver preservation. The aim of this research was to assess the effect of Celsior as compared with U.W. on immediate graft function and a 2-year follow-up of kidney transplants.


METHODS
A prospective multicenter randomized study was designed to evaluate the efficacy of the Celsior solution in the clinical preservation of the kidney. In this report, we present the data collected as of September 2000. One hundred donors were included in the trial resulting in 187 renal transplants. Ninety-nine kidneys were stored in Celsior solution and 88 in U.W. solution. The groups were comparable with regard to donor and recipient characteristics.


RESULTS
Delayed graft function occurred in 31.3% of the Celsior group and in 33.9% of the U.W. group (P=n.s.). Mean serum creatinine levels and mean daily urinary output were also comparable. Two year graft survival in kidneys preserved with Celsior was 84% as compared with 75% for U.W.-preserved kidneys without any significant statistical difference.


CONCLUSIONS
Our data show that the preservation of kidneys in Celsior solution in a clinical setting is equivalent to that of U.W. solution. When using Celsior during multiple-organ donor harvesting it would be possible to perform an in situ flush of all intra-abdominal and intrathoracic organs with a single cold storage solution.
Faenza
A
A
Department of Surgery and Transplantation, University of Bologna, Bologna, Italy.
Catena
F
F
Nardo
B
B
Montalti
R
R
Capocasale
E
E
Busi
N
N
Boggi
U
U
Vistoli
F
F
Di Naro
A
A
Albertazzi
A
A
Mosca
F
F
Cavallari
A
A
D000241:Adenosine / Q000494:pharmacology*; D000328:Adult; D000493:Allopurinol / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D015925:Cryopreservation; D004187:Disaccharides / Q000494:pharmacology*; D004231:Diuresis; D004573:Electrolytes / Q000494:pharmacology*; D005971:Glutamates / Q000494:pharmacology*; D005978:Glutathione / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects; D006639:Histidine / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D016030:Kidney Transplantation; D008353:Mannitol / Q000494:pharmacology*; D008875:Middle Aged; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D011446:Prospective Studies; D011887:Raffinose / Q000494:pharmacology*; D013997:Time Factors
C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D003404:Creatinine; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose