[Evaluation of the tonic and phasic effects of endogenous adenosine on the transmitter secretion in the neuromuscular junction].
Exogenous adenosine reduced the amplitude of multiquantal end-plate currents due to a depressant action on transmitter release. Theophylline did not change the amplitude of end-plate currents under low-rate motor nerve stimulation. The findings suggest a possibility of both tonic and phasic inhibitory actions of endogenous adenosine on transmitter release when utilization of this purine in synaptic cleft is inactivated.
Galkin
A V
AV
Medical University, Kazan, Russia.
Priazhnikov
E G
EG
Sokolova
E M
EM
Giniatullin
R A
RA
D000109:Acetylcholine / Q000378:metabolism*; D000241:Adenosine / Q000378:metabolism* / Q000494:pharmacology; D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology; D004558:Electric Stimulation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D009045:Motor Endplate / Q000502:physiology; D009469:Neuromuscular Junction / Q000378:metabolism / Q000502:physiology*; D011898:Ranidae; D009435:Synaptic Transmission
D058892:Adenosine Deaminase Inhibitors; D004791:Enzyme Inhibitors; D004176:Dipyridamole; D000241:Adenosine; D000109:Acetylcholine
Otsenka tonicheskogo i faznogo éffektov éndogennogo adenozina na sekretsiiu transmittera v nervno-myshechnom soedinenii.