Involvement of angiogenesis in weight-loss in tumor-bearing and diet-restricted animals.
The body's weight loss mechanism while in a tumor-bearing state is still unclear. In this study, we investigated expressions of angiogenic factors in the adipose tissue of tumor-bearing and diet-restricted rabbits evaluating the differences between the two groups. We postulated that low nutrition induced vasculogenesis to transport nutrition in the adipose tissues of diet-restricted rabbits, unlike in tumor-bearing rabbits, and that vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) were related to angiogenesis of the adipose tissues. Although we investigated the expressions of VEGF and PD-ECGF immunohistochemically in tumor-bearing and diet-restricted rabbits, there was no significant difference between the two groups. Whether angiogenesis of the adipose tissue in the diet-restricted animals may be observed during the nutritional recovery period should be investigated.
Sumi
T
T
Department of Obstetrics and Gynecology, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Ishiko
O
O
Yoshida
H
H
Hyun
Y
Y
Ogita
S
S
D000273:Adipose Tissue / Q000098:blood supply / Q000737:chemistry; D000818:Animals; D018952:Antigens, CD34 / Q000032:analysis; D001823:Body Composition; D001835:Body Weight / Q000502:physiology; D004038:Diet, Reducing; D004435:Eating; D016228:Endothelial Growth Factors / Q000032:analysis; D007150:Immunohistochemistry; D008222:Lymphokines / Q000032:analysis; D008297:Male; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000378:metabolism / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000503:physiopathology*; D011817:Rabbits; D013939:Thymidine Phosphorylase / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D015431:Weight Loss / Q000502:physiology*
D018952:Antigens, CD34; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013939:Thymidine Phosphorylase