title: Cowden's disease with vocal fold involvement.
abstract: Cowden's disease is a hereditary disorder characterized by oropharyngeal fibrosis and multiple hamartomas with potential malignant changes. We treated a 47-year-old man who had fibrotic lesions on the left vocal fold and an extensive amount of papillomatous lesions on the mucosa of the lips, tongue, and pharyngeal wall and on the skin of the axillae and buttocks. The pattern of distribution and the histopathologic features of these mucocutaneous lesions were diagnostic of Cowden's disease. To the best of our knowledge, this is the first reported case of Cowden's disease involving a vocal fold.
authors.affiliation: Division of Head and Neck/Plastic and Reconstructive Surgery, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR. edwardto@cuhk.edu.hk
authors.forename: E W
authors.initials: EW
authors.lastname: To
authors.forename: W M
authors.initials: WM
authors.lastname: Tsang
authors.forename: M W
authors.initials: MW
authors.lastname: Pak
authors.forename: J H
authors.initials: JH
authors.lastname: Cheng
authors.forename: G M
authors.initials: GM
authors.lastname: Tse
authors.forename: C A
authors.initials: CA
authors.lastname: van Hasselt
mesh_terms: D003937:Diagnosis, Differential; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis*; D006801:Humans; D007818:Laryngeal Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis*; D014827:Vocal Cords / Q000473:pathology*