Regioselective biomimetic oxidation of etodolac with iodosylbenzene catalyzed by halogenated and perhalogenated metalloporphyrins in dichloromethane.
The biomimetic oxidation of etodolac, an anti-inflammatory drug (1) with iodosylbenzene catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides TAPFe(III)Cl (7a-e) in dichloromethane gives 4-hydroxyetodolac (6) and 4-oxoetodolac (5) regioselectively in moderate yields.
Chauhan
S M
SM
Department of Chemistry, University of Delhi, India. smschauhan@chemistry.du.ac.in
Kandadai
S A
SA
Sahoo
B
B
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D017308:Etodolac / Q000737:chemistry*; D006900:Hydroxylation; D007462:Iodobenzenes; D009682:Magnetic Resonance Spectroscopy; D008665:Metalloporphyrins / Q000737:chemistry*; D008752:Methylene Chloride / Q000737:chemistry*; D010084:Oxidation-Reduction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007462:Iodobenzenes; D008665:Metalloporphyrins; D017308:Etodolac; D008752:Methylene Chloride; D003577:Cytochrome P-450 Enzyme System; C037276:iodosobenzene