Eradication of biofilm-forming Staphylococcus epidermidis (RP62A) by a combination of sodium salicylate and vancomycin.
Staphylococcus epidermidis is a major cause of infections associated with indwelling medical devices. Biofilm production is an important virulence attribute in the pathogenesis of device-related infections. Therefore, elimination of these biofilms is an ideal treatment. Salicylate (5 mM) combined with 1 microg of vancomycin per ml inhibited biofilm formation by S. epidermidis (RP62A) by >or=99.9%. When biofilm-coated polystyrene beads were exposed to 5 mM sodium salicylate and 4 microg of vancomycin per ml (one-half the minimum biofilm eradication concentration), there was a >99.9% reduction in viable count.
Polonio
R E
RE
Department of Biochemistry, Microbiology and Molecular Genetics, University of Rhode Island, Kingston, Rhode Island 02881, USA.
Mermel
L A
LA
Paquette
G E
GE
Sperry
J F
JF
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms; D004338:Drug Combinations; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D012980:Sodium Salicylate / Q000494:pharmacology*; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D018942:Macrolides; D014640:Vancomycin; D012980:Sodium Salicylate