Nonactin biosynthesis: disruption of the polyketide synthase genes, nonKJ, in Streptomyces griseus leads to an overall 96 decrease in macrotetrolide production, yet a net increase in nonactin analogues which incorporate isobutyrate.
Walczak
R J
RJ
Department of Chemistry The University of Montana, Missoula, Montana 59812-1656, USA.
Nelson
M E
ME
Priestley
N D
ND
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002087:Butyrates / Q000378:metabolism*; D058610:Isobutyrates; D018942:Macrolides / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000235:genetics*; D013237:Stereoisomerism; D013305:Streptomyces griseus / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002087:Butyrates; D058610:Isobutyrates; D018942:Macrolides; D009097:Multienzyme Complexes; C020380:isobutyric acid; C050476:nonactin