Acute Budd-Chiari syndrome, portal and splenic vein thrombosis in a patient with ulcerative colitis associated with antiphospholipid antibodies and protein C deficiency.
We report the case of a female patient who had severe thrombotic complications in peripheral (V. jugularis, subclavia, brachialis, poplitea) and visceral (portal and splenic) veins 4 years after the first diagnosis of severe ulcerative pancolitis. A thrombolysis therapy for subclavian and jugular vein thrombosis was performed without complication, but she soon developed acute thrombosis of the hepatic veins (acute Budd-Chiari syndrome). She quickly recovered after liver transplantation and now - 6 years later - she lives a normal life with continuous anticoagulation and medical therapy of the colitis.3 possible causes for the severe coagulation defect in this patient can be supposed: Thrombocytosis, protein C deficiency and an antiphospholipid antibody syndrome.
Junge
U
U
Medizinische Klinik, Städtische Kliniken Bielefeld-Rosenhöhe, Hannover, Germany. ulrich.junge@SK-bielefeld.de
Wienke
J
J
Schüler
A
A
D000293:Adolescent; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000175:diagnosis*; D006502:Budd-Chiari Syndrome / Q000175:diagnosis*; D003093:Colitis, Ulcerative / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation / Q000473:pathology; D011169:Portal Vein / Q000473:pathology; D020151:Protein C Deficiency / Q000175:diagnosis*; D013162:Splenic Vein; D019851:Thrombophilia / Q000175:diagnosis / Q000473:pathology; D013927:Thrombosis / Q000175:diagnosis* / Q000473:pathology