[Parameters of proliferative activity of hematopoietic cells in mice protected from irradiation by indralin in combination with Zn-metallothionein].
One day after the irradiation (dose 6 Gy) of mice protected by the injection of Zn-metallothionein (Zn-MT) in doze 8.6 mg/kg, 10-20 min before irradiation, then alpha-adrenomimetic indraline (150 mg/kg) 5-10 min before irradiation the increase in nucleic cell number, [3H] thymidine incorporation, and antioxidant activity in bone marrow in comparison with the control and indraline per se was revealed. In mice protected according to the scheme: Zn-MT in the same doze, then indraline (100 mg/kg) one day after, and then in 5-10 min exposure to 6 Gy it was found more than 9 times increase of endogeneous CFC in spleen on 8th day while indraline per se raised CFC number only 4.8 times. It was found that Zn-MT reduce the indraline acute toxicity. The data on radioprotective activity of monomeric and polymeric Zn-MT forms are submitted.
Koterov
A N
AN
State Research Center of Russia-Institute of Biophysics, Moscow, 123182, Russia. idphgen@rcibph.dol.ru
Pushkareva
N B
NB
Nikol'skiĭ
A V
AV
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D008668:Metallothionein / Q000008:administration & dosage* / Q000627:therapeutic use; D051379:Mice; D010636:Phenols / Q000008:administration & dosage* / Q000627:therapeutic use; D011832:Radiation Injuries / Q000503:physiopathology / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000627:therapeutic use
D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin; D008668:Metallothionein
Pokazateli proliferativnoĭ aktivnosti kletok krovetvornykh organov u mysheĭ, zashchishchennykh ot izlucheniia indralinom v sochetanii s Zn-metallotioneinom.