title: [A clinicopathological study of nodular lymphocyte predominance Hodgkin's disease].
abstract: OBJECTIVE
  To investigate the clinicopathological characteristics of nodular lymphocyte predominance Hodgkin's disease.
  
  
  METHODS
  Eleven samples of paraffin embedded lymph node and one of frozen lymph node from nodular lymphocyte predominance Hodgkin's disease patients were studied. HE staining, immunohistochemistry for CD3, CD19, CD20, CD30, CD45RB, kappa and lambda light chain and single L&H cell polymerase chain reaction (PCR) were performed.
  
  
  RESULTS
  The diagnosis of nodular lymphocyte predominance Hodgkin's disease was established by the identification of characteristic L&H cells in the nodular small lymphocytes and histiocytes background. L&H cells expressed CD19(10/12), CD20(12/12), CD45RB(12/12) and kappa light chain (11/12). IgH and V kappa 4 family gene rearrangements were detected in the single L&H cell. Eight of the patients survived more than 5 years.
  
  
  CONCLUSIONS
  Nodular lymphocyte predominance Hodgkin's disease has a very slow disease course and a better prognosis. It is a malignant lymphoma derived from B cells.
authors.affiliation: Department of Pathology, Zunyi Medical College, Zunyi 563003.
authors.forename: F
authors.initials: F
authors.lastname: Deng
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: W
authors.initials: W
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018951:Antigens, CD20 / Q000096:biosynthesis; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000145:classification / Q000473:pathology*; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis; D017730:Ki-1 Antigen / Q000096:biosynthesis; D016256:Lewis X Antigen / Q000096:biosynthesis; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D018951:Antigens, CD20; D007145:Immunoglobulin kappa-Chains; D017730:Ki-1 Antigen; D016256:Lewis X Antigen