title: Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis. A study in immature rabbits.
abstract: We examined the effect on bone mineral density (BMD) of a single dose of 3 mg/kg of the bisphosphonate, pamidronate (Novartis) in distraction osteogenesis in immature rabbits. Seventeen rabbits (9 control, 8 given pamidronate) were examined by dual-energy x-ray absorptiometry. There was a significant increase in the BMD in the pamidronate group compared with the control animals. The mean areal BMD (g/cm2) in the bone proximal and distal to the regenerate was increased by 40% and 39%, respectively, compared with the control group (p < 0.05). The BMD of the regenerate bone was increased by a mean of 43% (p < 0.05). There was an increase of 22% in the mean area of regenerate formed in the pamidronate group (p < 0.05). Histological examination of bone in nine rabbits (5 control, 4 pamidronate) showed an increase in osteoblastic rimming and mineralisation of the regenerate, increased formation of bone around the pin sites and an increase in the cortical width of the bone adjacent to the regenerate in the rabbits given pamidronate. Pamidronate had a markedly positive effect. It reduced the disuse osteoporosis normally associated with lengthening using an external fixator and increased the amount and density of the regenerate bone. Further study is required to examine the mechanical properties of the regenerate after the administration of pamidronate.
authors.affiliation: Department of Paediatrics and Child Health, Royal Alexandra Hospital for Children, Westmead, New South Wales, Australia.
authors.forename: D G
authors.initials: DG
authors.lastname: Little
authors.forename: M S
authors.initials: MS
authors.lastname: Cornell
authors.forename: J
authors.initials: J
authors.lastname: Briody
authors.forename: C T
authors.initials: CT
authors.lastname: Cowell
authors.forename: S
authors.initials: S
authors.lastname: Arbuckle
authors.forename: C M
authors.initials: CM
authors.lastname: Cooke-Yarborough
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects*; D004164:Diphosphonates / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008297:Male; D019857:Osteogenesis, Distraction / Q000009:adverse effects*; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D000077268:Pamidronate; D011817:Rabbits
chemical_list: D004164:Diphosphonates; D000077268:Pamidronate