[The effect of gamma-aminobutyric acid injected into lateral brain ventricle of rats after prenatal cadmium intoxication on flash visual evoked potentials (FVEP)].
OBJECTIVE
To find out any influence of gamma-aminobutyric acid (GABA) injected into lateral brain ventricle in newborn rats prenatally exposed to cadmium (Cd).


METHODS
18 white, Wistar, offspring rats were divided into 3 groups, each consisting of 6 rats (control, 5 ppm and 50 ppm of Cd in drinking water). Newborns were examined when they were 3-6 months old. FVEP were recorded before and after GABA injections. Two doses of GABA were used, 10 and 100 nmols. The statistic analysis with the test of t-Student was performed to estimate the amplitudes and latencies of the negative wave N1 and the next positive one P2. p < 0.05 was used to indicate significant difference.


RESULTS
No significant changes in the latencies of peak N1 and P2 in the control and Cd 5 ppm groups (101-103%) after 10 nmols GABA were observed. However, the shortened (91-97%) of them was observed after both doses of GABA in Cd 50 ppm group. The mean value of amplitude of N1 in control rats increased to 127% after 10 nmols GABA and 142% after 100 nmols GABA. Moreover, the mean amplitude of P2 in this group increased to 108% and 146%, respectively. The high significant increase of the amplitudes of N1 (181-280%) and P2 (160-177%) waves were received after both doses of GABA in Cd groups.


CONCLUSIONS
Cadmium increased the sensitivity of GABA-receptors in the OUN.
Herba
E
E
Katedra i Oddział Kliniczny Okulistyki Slaskiej AM w Katowicach Szpital Specjalistyczny Nr 1 w Bytomiu ul. Zeromskiego 7 41-902 Bytom.
Pojda-Wilczek
D
D
Pojda
S M
SM
Szkilnik
R
R
Plech
A
A
D000818:Animals; D002104:Cadmium / Q000009:adverse effects*; D002552:Cerebral Ventricles / Q000187:drug effects*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005260:Female; D007267:Injections; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000187:drug effects; D012680:Sensitivity and Specificity; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D018079:Receptors, GABA; D002104:Cadmium; D005680:gamma-Aminobutyric Acid
Wpływ kwasu gamma-aminomasłowego (GABA) podanego do komory bocznej mózgu szczurów po prenatalnej intoksykacji kadmem na odpowiedzi wzrokowych potencjałów wywołanych błyskami (FVEP).