Pemphigus foliaceus developing after metastasis of cutaneous squamous cell carcinoma to regional lymph nodes.
We describe a patient in whom pemphigus foliaceus developed after cutaneous squamous cell carcinoma (SCC) metastasized to regional lymph nodes. Immunologic analysis revealed that production of anti-desmoglein 1 autoantibodies started when SCC metastasized, and the SCC expressed desmoglein 1, suggesting a pathogenic role of metastasized SCC in developing pemphigus foliaceus.
Inaoki
M
M
Department of Dermatology, Kanazawa University School of Medicine, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8641, Japan. inaoki-m@med.kanazawa-u.ac.jp
Kaji
K
K
Furuse
S
S
Fujimoto
A
A
Komatsu
N
N
Takata
M
M
Takehara
K
K
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D015820:Cadherins / Q000032:analysis* / Q000096:biosynthesis; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D051183:Desmoglein 1; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D010392:Pemphigus / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D001323:Autoantibodies; D015820:Cadherins; D051183:Desmoglein 1