title: [Vascularized fibula transplantation in orthopedic oncology. Personal experience and review of the literature].
abstract: Primary malignant bone tumors can be treated predominantly with limb salvage. After resection of large articular segments adjacent to the dia- or metaphysis of long bones modular endoprosthetic devices are most commonly used for reconstruction. In case non-vascularized corticocancellous bone is transplanted in order to bridge extensive bone defects, the risk of pseudarthrosis and fracture of the donor bone is significantly higher in comparison to a free vascularized transplant. From 1988 until 1999 we treated 20 patients with extensive bone defects after resection of tumors affecting the upper and lower extremity using a vascularized fibular graft. In this retrospective analysis we collected the data focusing on bone integration and functional outcome. The graft union was classified according to the standards of the "International Symposium of Limb Salvage". Evaluation of the functional outcome was quantified using the Enneking-score. The stabilisation of the transplant was obtained exclusively by plate fixation in the upper extremity. In 10 in a total of 12 patients the reconstruction using a vascularized fibula transfer was reinforced with an allograft in the lower extremity. The functional evaluation score reached 73% of normal function at the last follow-up. After 18 months the radiographic evaluation of graft union was "excellent" in 75%, "good" in 11%, "fair" in 6% and "poor" in 9% according to the criteria of the ISOLS. Main complications were graft fracture in of 15% and pseudarthrosis in 14.3%. Reconstruction of extensive bone defects using free vascularized fibula grafts are a demanding operative procedure. The procedure combines a biologic form of reconstruction with a legitimate expectation of good long term outcome and a relatively low rate of complications.
authors.affiliation: Sektion Orthopädische Onkologie, Stiftung Orthopädische Universitätsklinik Heidelberg.
authors.forename: C
authors.initials: C
authors.lastname: Kühner
authors.forename: R
authors.initials: R
authors.lastname: Simon
authors.forename: L
authors.initials: L
authors.lastname: Bernd
mesh_terms: D000293:Adolescent; D000328:Adult; D001132:Arm / Q000000981:diagnostic imaging / Q000601:surgery; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005360:Fibula / Q000098:blood supply / Q000637:transplantation; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011859:Radiography; D012189:Retrospective Studies
vernacular_title: Die vaskularisierte Fibulatransplantation in der orthopädischen Onkologie. Eigene Erfahrung und Literaturübersicht.