Cathodic adsorptive stripping square-wave voltammetry of the anti-inflammatory drug meloxicam.
The adsorptive behavior of the anti-inflammatory drug meloxicam was studied by cyclic, differentia-pulse and square-wave voltammetry on a hanging mercury drop electrode (HMDE). The drug was accumulated at HMDE and a well-defined stripping peak current was obtained at -1.42 V vs. Ag/AgCl (saturated KCl) electrode in acetate buffer solution (pH 5.0). A voltammetric procedure was developed for the determination of meloxicam using square-wave cathodic adsorptive stripping voltammetry (SW-CASV). The optimum working conditions for the determination of the drug were established. The analysis of meloxicam in human plasma was carried out satisfactorily.
Radi
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AE
Department of Chemistry, Faculty of Science, Mansoura University, Dumyat, Egypt. abdradi@yahoo.com
Ghoneim
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M
Beltagi
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A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000737:chemistry*; D001798:Blood Proteins / Q000737:chemistry; D002138:Calibration; D004563:Electrochemistry; D006801:Humans; D000077239:Meloxicam; D013843:Thiazines / Q000097:blood / Q000737:chemistry*; D013844:Thiazoles / Q000097:blood / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001798:Blood Proteins; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam