Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas.
Eighteen primary human malignant mesotheliomas obtained from 18 patients were screened for point mutations and microdeletions/insertions in all exons of the tumour suppressor gene PTEN/MMAC1 by SSCP analysis. No mutation could be found. Our preliminary data indicate that disarrangements of PTEN/MMAC1 are at least not frequently involved in mesothelioma formation.
Papp
T
T
Department of Biological Sciences, Institute for Cell Biology and Biosystems Technology, University of Rostock, D-18051 Rostock, Germany. thilo.papp@biologie.uni-rostock.de
Schipper
H
H
Pemsel
H
H
Unverricht
M
M
Muller
K M
KM
Wiethege
T
T
Schiffmann
D
D
Rahman
Q
Q
D016147:Genes, Tumor Suppressor; D006801:Humans; D008654:Mesothelioma / Q000235:genetics*; D009154:Mutation; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D025521:Tumor Suppressor Proteins; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human