Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid.
We report the first case of granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid (ATRA) in a patient with acute promyelocytic leukemia (APL). Acute renal failure during treatment with ATRA has been previously reported as a part of an ATRA syndrome or a thrombotic complication of a hypercoagulable state. This case indicates an alternative mechanism of acute renal failure occurring during ATRA therapy.
Tomita
N
N
Department of Hematology , Fujieda Municipal General Hospital, Shizuoka, 426-8677, Japan. cavalier@ch-yamate.dienet.com
Kanamori
H
H
Fujita
H
H
Maruta
A
A
Naitoh
A
A
Nakamura
S
S
Ota
Y
Y
Nozue
N
N
Kihara
M
M
Ishigatsubo
Y
Y
D000368:Aged; D001550:Benzamidines; D017985:Dalteparin / Q000627:therapeutic use; D004334:Drug Administration Schedule; D016670:Gabexate / Q000627:therapeutic use; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D015255:Idarubicin / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000150:complications; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000150:complications; D019851:Thrombophilia / Q000150:complications; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*
D001550:Benzamidines; D006146:Guanidines; D016670:Gabexate; D014212:Tretinoin; D017985:Dalteparin; C032855:nafamostat; D015255:Idarubicin