The bioseparation needs for tomorrow.
Will we replace oil with wheat or corn as a feedstock for producing natural plastic? The success of biotechnology for bulk product manufacturing will heavily depend on engineering solutions in the downstream processes in which separation and purification have a crucial role with respect to commercial development. Development of efficient bioseparation methods is important for a broad range of business areas including pharmaceuticals, nutrition and health products, bio-based materials and crop protection chemicals. Depending on the value of the end product and the scale of production, the processing required varies significantly. Key factors that have an impact on the choice of separation strategy include process throughput, particle size of the product and impurities and the desired end-product concentration. The development of efficient, economical and selective separation methods will be required for successful commercialization of bioprocesses. Despite this well-recognized need, there are relatively few available methods for commercial implementations. Development of novel mechanical systems for selective separation of solid and liquid mixtures must become a top priority for current research investment to reduce the reliance on expensive chromatographic and thermal separation methods.
Keller
K
K
DuPont Central Research & Development, PARSAT Experimental Station, E304/A207, Wilmington, DE 19880-0304, USA. karsten.keller@usa.dupont.com
Friedmann
T
T
Boxman
A
A
D001688:Biological Products / Q000302:isolation & purification*; D001709:Biotechnology / Q000379:methods / Q000639:trends*; D002469:Cell Separation / Q000379:methods / Q000639:trends; D046911:Macromolecular Substances; D011506:Proteins / Q000302:isolation & purification
D001688:Biological Products; D046911:Macromolecular Substances; D011506:Proteins