Synthesis of cis- and trans-5,8-dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone.
Cis- and trans-5,8-dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone (1a, 1b) were for the first time synthesized from 5,8-dihydroxy-1,4-naphthoquinone (naphthazazine) (6) as a starting material and racemic triol (3) was first synthesized from 7. The configuration of 1a was determined by X-ray analysis.
Arima
S
S
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan. arimas@pharm.kitasato-u.ac.jp
Yamada Konda
Y
Y
Takeda
K
K
Takayanagi
H
H
Harigaya
Y
Y
D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008958:Models, Molecular; D009285:Naphthoquinones / Q000138:chemical synthesis*; D013237:Stereoisomerism
C450641:5,8-dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone; D007202:Indicators and Reagents; D009285:Naphthoquinones