Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain.
Hundreds of millions of people now die over the age of 80 years primarily due to twentieth century progress in hygiene, chemotherapy, and immunology. With a longer average lifespan, the need to improve quality of life during the latter decades is more compelling. "Aging--The Epidemic of the New Millenium," a recent international conference (Monte Carlo, June 17-18, 2000), showed with peculiar clarity that a safe and efficient drug strategy to slow the age-related decay of brain performance is still missing. This review summarizes the physiologic and pharmacologic arguments in favor of a peculiar lifelong prophylactic medication with reasonable chances to keep in check brain aging and decrease the precipitation of age-related neurological diseases.
Knoll
J
J
Department of Pharmacology, Faculty of General Medicine, Semmelweis University, H-1445 Budapest, Hungary. joszefknoll@hotmail.com
D000375:Aging / Q000187:drug effects*; D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010300:Parkinson Disease / Q000188:drug therapy; D011437:Propylamines / Q000494:pharmacology; D012642:Selegiline / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*
C404200:1-(benzofuran-2-yl)-2-propylaminopentane; D001572:Benzofurans; D002395:Catecholamines; D018696:Neuroprotective Agents; D011437:Propylamines; C068473:N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane; D012642:Selegiline; D012701:Serotonin