[Trends in the pharmaceutical research of ribonucleases and their therapeutic uses].
As one of the most popular model enzymes, the structure and evolution of ribonucleases (RNases) have been studied thoroughly. But until recently, scientists found out that RNases demonstrated a series of important biological functions, such as controlling blood vessel formation, killing tumor cells and inhibiting virus. Now immunotoxin, the antibody-toxin conjugate, becomes a research hot spot. RNases with cytotoxicity are the candidates for the toxin moiety of the immunotoxins. In this paper, the newly found cytotoxic functions of RNases are discussed in detail.
Zhang
Y
Y
State Key Laboratory of Biochemical Engineering, Chinese Academy of Sciences, Beijing 100080.
Li
W
W
Su
Z
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004722:Endoribonucleases / Q000494:pharmacology; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology*; D066298:In Vitro Techniques; D012259:Ribonuclease, Pancreatic / Q000494:pharmacology; D012260:Ribonucleases / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D000922:Immunotoxins; D004722:Endoribonucleases; D012260:Ribonucleases; C046366:angiogenin; C032523:ribonuclease SPL; D012259:Ribonuclease, Pancreatic; C058703:ranpirnase