title: Tetrandrine inhibits inward rectifying potassium current in cultured bovine aortic endothelial cells.
abstract: OBJECTIVE
  To study the effect of tetrandrine (Tet) on inward rectifying potassium current in cultured bovine aortic endothelial cells.
  
  
  METHODS
  Inward rectifying potassium current (IRK) was observed by the whole cell patch-clamp technique.
  
  
  RESULTS
  IRK was inhibited by Tet in a concentration-dependent manner and recovered to normal after wash with drug-free external solution. IRK was reduced from (582 +/- 48) pA to (221 +/- 40) pA at a holding potential of -70 mV by Tet 30 mumol/L. IC50 was 2.8 mumol/L.
  
  
  CONCLUSIONS
  Tet inhibited inward rectifying potassium current in cultured bovine aortic endothelial cells.
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: W B
authors.initials: WB
authors.lastname: Liu
authors.forename: G Q
authors.initials: GQ
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Xiao
authors.forename: X
authors.initials: X
authors.lastname: Mao
authors.forename: Y
authors.initials: Y
authors.lastname: Shi
authors.forename: J P
authors.initials: JP
authors.lastname: Wu
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000166:cytology; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology*; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; D015221:Potassium Channels; C009438:tetrandrine