[Experimental study of cord blood plasma enhancing the anti-leukemia effect of Ara-C].
OBJECTIVE
To study the in vitro effect of cord blood plasma(CBP) on the sensitivity of acute myeloid leukemia(AML) cells to cytosine arabinoside (Ara-C).


METHODS
Cytotoxicity of Ara-C was detected by MTT assay in twenty-eight patients.


CONCLUSIONS
The sensitivity of AML cells to Ara-C was heterogeneous, but CBP could significantly enhanced the cytotoxic activity of Ara-C to drug resistant AML cells.
Zhang
X
X
Department of Hematology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006.
Chen
Y
Y
Wang
X
X
D000293:Adolescent; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D002453:Cell Cycle; D003561:Cytarabine / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005260:Female; D005312:Fetal Blood; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010949:Plasma; D011994:Recombinant Proteins / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000964:Antimetabolites, Antineoplastic; D011994:Recombinant Proteins; D003561:Cytarabine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor