Newborn infants with yellow brains: the discovery of kernicterus in Germany, 1875-1908.
Kernicterus, described in the period just before Kinnier Wilson's publication of his study of hepatolenticular degeneration, served him as a model of liver dysfunction associated with neurological disorder. The work of the early investigators of kernicterus, especially their descriptions of the pathological changes in the brain, led Wilson to postulate that a hepatotoxin was responsible for the neurological entity that he elucidated.
Sourkes
T L
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Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
D001921:Brain; D005858:Germany; D006527:Hepatolenticular Degeneration / Q000266:history*; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D007231:Infant, Newborn; D007647:Kernicterus / Q000266:history*; D008107:Liver Diseases / Q000266:history*