title: [The relationship between ophthalmic nerve lesion in glaucoma and ocular and systemic haemodynamic disturbance].
abstract: OBJECTIVE
  To explore the relationship between the optic nerve lesion in glaucoma and ocular and systemic haemodynamic disturbance.
  
  
  METHODS
  The color Doppler imaging was used to study blood velocity in the ophthalmic, the central retinal and the short posterior ciliary arteries in 34 patients with primary open angle glaucoma, 31 patients with low tension glaucoma and 90 healthy controls. The peak systolic velocity(PSV), the end diastolic velocity (EDV) and resistive index (RI) in each artery were measured, moreover the nailfold microcirculation and blood viscosity in each patient were examined.
  
  
  RESULTS
  Compared with the control group, the PSV and EDV of the central retinal arteries were significantly lower while the RI of the central retinal arteries was significantly higher in both POAG and LTG patients. The RI of the short posterior ciliary arteries however was significantly higher in POAG. Nailfold microcirculation shows that some important parameters, including flow pattern, loop surrounding, morphological weighted value, total weighted value and capillary deformity rate in the two glaucoma groups were higher, whereas the flow velocity was lower than in the control group. The plasm viscosity and the whole blood viscosity (low spear) were higher than normal. According to our measurements, the nailfold microcirculation and blood viscosity was worse at the end stage of glaucoma than at early stage. The correlative analysis between measurement results of color doppler imaging and microcirculation and heamorrheology showed that nailfold microcirculation morphological weighted value was negatively correlated with the EDV of the central retinal artery and positively correlated with the RI of the central retinal artery in LTG patients.
  
  
  CONCLUSIONS
  The abnormity of ocular haemodynamics and systemic microcirculation and blood viscosity is one important factor of optic nerve damage in glaucoma.
authors.affiliation: Department of Ophthalmology, Beijing Tong Ren Hospital, 100730.
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Yuan
authors.forename: W
authors.initials: W
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001809:Blood Viscosity; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000209:etiology / Q000503:physiopathology*; D011446:Prospective Studies; D012161:Retinal Artery / Q000000981:diagnostic imaging; D018615:Ultrasonography, Doppler, Color