title: Two new pyrrolidine alkaloids, radicamines A and B, as inhibitors of alpha-glucosidase from Lobelia chinensis Lour.
abstract: Two new pyrrolidine alkaloids, radicamines A and B were isolated as inhibitors of alpha-glucosidase from Lobelia chinensis Lour. (Campanulaceae). Radicamines A and B were formulated as (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(3-hydroxy-4-methoxyphenyl)-pyrrolidine (1) and (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine (2) on the basis of spectroscopic analyses and chemical methods.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shibano
authors.forename: D
authors.initials: D
authors.lastname: Tsukamoto
authors.forename: A
authors.initials: A
authors.lastname: Masuda
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: G
authors.initials: G
authors.lastname: Kusano
mesh_terms: D001208:Asia; D029422:Campanulaceae / Q000737:chemistry*; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D029746:Lobelia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011759:Pyrrolidines / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D011759:Pyrrolidines; C450646:radicamine A; C450645:radicamine B; D005959:Glucosidases