[Dose-effect and time-effect characteristics in process of tumorigenesis under combined action of ionizing radiation and chemical carcinogen].
Studying of dose and time dependences of frequency of adenomas appearing under the combined effect of radiation and urethane ingressed during different terms after irradiation has show that the frequency of tumours is determined both by radiation dose, and the time interval between irradiation and ingressing of cancerogenic substance. The data obtained show the period of preservation of the induced damages and non-linearity of the process of tumour-formation under the combined effect of radiation and toxic factors on the organism. The latter is necessary to be taken into account when forecasting the radiation risk under the real ecological conditions.
Malenchenko
A F
AF
Institute of Radioecological Problems, National Academy of Sciences of Belarus, Minsk, 220109. irep@sosny.bas-net.by
Sushko
S N
SN
Kuz'mina
T S
TS
D000236:Adenoma / Q000209:etiology*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D008175:Lung Neoplasms / Q000209:etiology*; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D013997:Time Factors; D014520:Urethane / Q000633:toxicity*
D002273:Carcinogens; D014520:Urethane
Zavisimosti doza-éffekt i vremia-éffekt v protsesse opukholeobrazovaniia pri sochetannom deĭstvii ioniziruiushchego izlucheniia i khimicheskogo kantserogena.