Targeted delivery of drugs to the gastrointestinal tract.
The oral route is attractive for drug administration because it is associated with patient acceptability, less stringent production conditions, and lower costs. However, gastrointestinal destruction of labile molecules and low levels of absorption generally render oral delivery of peptides and proteins ineffective. Several strategies have the potential to enhance the efficacy of orally administered drugs. Bioadhesion is an approach for increasing interaction between drugs and the mucosae. Bioadhesive systems can be nonspecific, achieving adhesion via mechanical processes or specific systems that recognize receptors on epithelial cells. Lectins are one group of specific bioadhesives with many suitable properties for targeting of cells in the gastrointestinal tract (GIT). This review assesses the potential of lectins in the delivery of drugs and vaccines to the GIT.
Lavelle
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Institute for Immunology, Department of Biology, National University of Ireland Maynooth, Co. Kildare. elavelle@ireland.com
D000268:Adhesiveness; D000284:Administration, Oral; D000818:Animals; D004064:Digestive System / Q000276:immunology / Q000378:metabolism*; D004068:Digestive System Physiological Phenomena; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D037102:Lectins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D008221:Lymphoid Tissue / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D010581:Peyer's Patches / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D014612:Vaccines / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D014805:Vitamin B 12 / Q000378:metabolism
D004337:Drug Carriers; D007070:Immunoglobulin A; D037102:Lectins; D004364:Pharmaceutical Preparations; D014612:Vaccines; D014805:Vitamin B 12