[Identification of beta-FBG-455G/A polymorphisms in 210 samples of Guangdong population and the relationship with plasma fibrinogen level].
OBJECTIVE
To analyze the frequency of beta-fibrinogen (beta-FBG) gene G/A-455 polymorphisms in Guangdong Chinese population and the relationship between genotype and plasma fibrinogen levels.


METHODS
DNA of 210 samples were analyzed by using PCR-RFLP. Turbidimetric method for the levels of plasma fibrinogen was performed in 92 samples.


RESULTS
The frequency of beta-FBG G/A-455 genotype A/A was 0.038; G/G was 0.514 and G/A was 0.448. The frequency of the A-allele was 0.262. The average plasma fibrinogen level in 46 samples of genotype G/A was (2.18 +/- 0.24) g/L and in 42 samples of G/G genotype was (2.03 +/- 0.25) g/L. There was significant difference between genotype and plasma fibrinogen (P < 0.01).


CONCLUSIONS
The frequency of beta-FBG G/A-455 A-allele in Guangdong Chinese population is higher than that in European. The plasma fibrinogen level in G/A genotype is higher than that in G/G genotype. It suggested that the beta-FBG gene expression might be associated with the genotype.
Liu
G
G
Research Lab of Blood Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001.
Li
F
F
Cai
W
W
D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People; D005260:Female; D005340:Fibrinogen / Q000235:genetics* / Q000378:metabolism*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length; D044465:White People
C115499:BBeta fibrinogen; D005340:Fibrinogen