Treatment of psoriasis. Part 2. Systemic therapies.
The array of systemic medications used in the treatment of psoriasis is rapidly expanding. In the United States, methotrexate, retinoids, and cyclosporine are the only systemic drugs approved by the Food and Drug Administration for the treatment of psoriasis. Monitoring and dosage recommendations for these medications are reviewed. Other drugs that are currently available include tacrolimus, mycophenolate mofetil, hydroxyurea, 6-thioguanine, and sulfasalazine. Experience with these drugs is summarized, and dosage and monitoring recommendations in published literature are presented. Combinations of different treatments are addressed and investigational therapies that are in development are reviewed.
Lebwohl
M
M
Department of Dermatology, The Mount Sinai School of Medicine of New York University, One Gustave L. Levy Place, New York, NY 10029, USA. mark.lebwohl@mssm.edu
Ali
S
S
D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use*
D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D012176:Retinoids; D016572:Cyclosporine; D008727:Methotrexate