[Analysis of prenatal diagnosis for 120 cases of beta-thalassemia].
OBJECTIVE
To analyse the results of prenatal gene diagnosis of beta-thalassemia.


METHODS
By using the reverse dot blot method with an allele specific oligonucleotide probe(ASO/DRB).


RESULTS
In 120 cases of prenatal gene diagnosis, there are 30 of normal fetal; 63 of beta-thalassemia heterozygotes; 26 of beta-thalassemia homozygotes or dual heterozygotes; one of no diagnosis because the beta mutated gene can not be detected in one side of the parent.


CONCLUSIONS
Acording to the follow-up studies, the babies unconcordance with prenatal diagnosis have not been found, the accuracy rate being 100%. Amniotic fluid specimen of the middle stage of pregnancy is the best for detection.
Zeng
R
R
Medical Genetics Department, SUN Yat-sen University of Medical Science, Guangzhou 510089.
You
Z
Z
Hu
B
B
D000649:Amniocentesis; D002872:Chromosome Deletion; D005260:Female; D005500:Follow-Up Studies; D006580:Genetic Carrier Screening; D006720:Homozygote; D006801:Humans; D009154:Mutation; D011247:Pregnancy; D011296:Prenatal Diagnosis; D017086:beta-Thalassemia / Q000175:diagnosis* / Q000235:genetics*