Spectrophotometric methods for the determination of ritodrine hydrochloride and its application to pharmaceutical preparations.
Two simple and sensitive spectrophotometric methods are described for the determination of ritodrine hydrochloride (RTH) in both pure and dosage forms. The methods are based on the interaction of diazotised p-nitroaniline (DPNA) and sulphanilic acid (DSNA) with RTH in an alkaline medium. The resulting azo dyes are measured at 480 nm (for the DPNA method) and at 440 nm (for the DSNA method) and are stable for more than 1 h. The optimum reaction conditions and other analytical parameters are evaluated. A study of the effect of commonly associated excipients and additives do not interfere with the determinations. Statistical analysis of results indicates that the methods are precise and accurate.
Revanasiddappa
H D
HD
Department of Studies in Chemistry, University of Mysore, Manasagangotri, India. manjub94@yahoo.com
Manju
B
B
D000814:Aniline Compounds / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004347:Drug Interactions; D005079:Excipients; D012312:Ritodrine / Q000032:analysis* / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods*; D013425:Sulfanilic Acids / Q000737:chemistry; D013607:Tablets; D015149:Tocolytic Agents / Q000032:analysis* / Q000737:chemistry
D000814:Aniline Compounds; D005079:Excipients; D013425:Sulfanilic Acids; D013607:Tablets; D015149:Tocolytic Agents; C019498:4-nitroaniline; D012312:Ritodrine