title: GenePath: a computer program for genetic pathway discovery from mutant data.
abstract: The sequencing of the human genome and the genomes of several model organisms is the first step toward the long-term objective of genetic research: the identification of all genes, and the discovery of their functions and mutual interactions. This article presents a methodology and a computer program called GenePath to support the discovery of gene function. GenePath uses mutant data and available genetic knowledge to identify potential genetic pathways. Several pilot applications based on experimental results from Dictyostelium and C. elegans confirmed the usefulness of the proposed schema. Our results suggest that GenePath is a valuable tool that can be used as an intelligent assistant to support genetic reasoning.
authors.affiliation: Faculty of Computer and Information Sciences, Ljubljana, Slovenia. janez.demsar@fri.uni-lj.si
authors.forename: J
authors.initials: J
authors.lastname: Demsar
authors.forename: B
authors.initials: B
authors.lastname: Zupan
authors.forename: I
authors.initials: I
authors.lastname: Bratko
authors.forename: A
authors.initials: A
authors.lastname: Kuspa
authors.forename: J A
authors.initials: JA
authors.lastname: Halter
authors.forename: R J
authors.initials: RJ
authors.lastname: Beck
authors.forename: G
authors.initials: G
authors.lastname: Shaulsky
mesh_terms: D000818:Animals; D001185:Artificial Intelligence; D017173:Caenorhabditis elegans / Q000235:genetics; D019295:Computational Biology; D004023:Dictyostelium / Q000235:genetics; D023281:Genomics / Q000379:methods*; D009154:Mutation; D012984:Software