The relationship between major histocompatibility receptors and innate immunity in teleost fish.
Studies of the innate immune system have recently shown that, in addition to its role in producing the primary response that slows down pathogens, it may also play an important role in initiating and directing the type of response that the adaptive immune system makes. These discoveries have shown a complex web of control containing new roles for the innate immune system in organizing responses of T-cell to antigens being presented by major histocompatibility receptors, as well as new roles for those receptors in innate immune responses. Both of these activities are managed through feedback networks involving elements of both the innate and adaptive immune system. This paper will discuss these newly discovered interactions and how they are influencing current theories regarding the initiation of adaptive immune responses. In particular, it will highlight the recent progress that is being made towards understanding these relationships in the immune systems of teleost fish.
Dixon
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Department of Biology, University of Waterloo, 200 University Ave West, Waterloo, Ontario, N2L 3G1, Canada. bdixon@uwaterloo.ca
Stet
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RJ
D000222:Adaptation, Physiological; D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D005246:Feedback; D005399:Fishes / Q000235:genetics / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology; D008285:Major Histocompatibility Complex; D008954:Models, Biological; D008969:Molecular Sequence Data; D011946:Receptors, Antigen / Q000235:genetics / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D011946:Receptors, Antigen