Fatal overdose with trazodone: case report and literature review.
A fatal case of suicide with trazodone alone in a 40-year-old patient is reported. Life-threatening arrhythmias, such as torsades de pointes and complete AV block, are recorded. Blood collected at admission contained a trazodone toxic concentration of 25.4 micrograms/mL. The patient developed multiple organ failure and died less than 24 hours after his admission to the emergency department. The authors discuss the effects of overdose of trazodone, a well-known safe antidepressant drug.
de Meester
A
A
Cardiology Department, Jolimont Hospital, 7100 Haine Saint Paul, Belgium.
Carbutti
G
G
Gabriel
L
L
Jacques
J M
JM
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004562:Electrocardiography; D006801:Humans; D008297:Male; D013405:Suicide; D014196:Trazodone / Q000506:poisoning*
D018687:Antidepressive Agents, Second-Generation; D014196:Trazodone