New model of oropharyngeal candidiasis in mice.
We established a straightforward murine model of oropharyngeal candidiasis. Mice were immunosuppressed with cortisone acetate, anesthetized, and then inoculated by placing cotton wool balls saturated with Candida albicans sublingually for 2 h. A prolonged, reproducible infection was induced. This model may be useful for antifungal screening or pathogenesis studies.
Kamai
Y
Y
Biological Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan. ykamai@shina.sankyo.co.jp
Kubota
M
M
Kamai
Y
Y
Hosokawa
T
T
Fukuoka
T
T
Filler
S G
SG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002180:Candidiasis, Oral / Q000382:microbiology* / Q000473:pathology; D002452:Cell Count; D003348:Cortisone / Q000494:pharmacology; D004195:Disease Models, Animal; D004947:Esophagus / Q000473:pathology; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D010608:Pharyngeal Diseases / Q000382:microbiology* / Q000473:pathology; D013752:Tetracycline / Q000494:pharmacology; D014059:Tongue / Q000473:pathology
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D013752:Tetracycline; D003348:Cortisone