Determination of clopidol residues in chicken tissues by liquid chromatography: part III. Quality control analysis of export chickens.
A summary is presented of the liquid chromatographic (LC) determination of clopidol residues in export chickens from 1992 to 1999. Over the past 8 years, we analyzed >7000 chicken samples. A total of 0.66% of samples contained clopidol residues, ranging from 0.005 to 0.79 mg/kg; however, none exceeded 3 mg/kg, the Chinese maximum residue limit. In comparison with 1992, the number of samples multiplied 70-fold, and the frequency of clopidol found in samples decreased 148-fold in 1999. The chickens inspected were exported to foreign countries; all were cleared by the buyers with no disputes. This report also introduces the critical control points of the proposed LC method as well as identification of false-positive procedures by both experience and LC/mass spectrometric confirmation. Our experiences over the past 8 years have demonstrated that the ruggedness of the proposed LC method is quite good.
Pang
G F
GF
Qinhuangdao Entry-Exit Inspection and Quarantine Bureau, Hebei, People's Republic of China.
Cao
Y Z
YZ
Fan
C L
CL
Zhang
J J
JJ
Li
X M
XM
D000818:Animals; D002138:Calibration; D002645:Chickens / Q000378:metabolism*; D002852:Chromatography, Ion Exchange; D002853:Chromatography, Liquid; D003007:Clopidol / Q000032:analysis*; D003049:Coccidiostats / Q000032:analysis*; D004350:Drug Residues / Q000032:analysis*; D005189:False Positive Reactions; D007202:Indicators and Reagents; D008460:Meat / Q000032:analysis* / Q000592:standards*; D011786:Quality Control; D012015:Reference Standards; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D014018:Tissue Distribution
D003049:Coccidiostats; D007202:Indicators and Reagents; D012997:Solvents; D003007:Clopidol