Ovarian conservation in a woman of reproductive age with müllerian adenosarcoma.
BACKGROUND
Total abdominal hysterectomy with bilateral salpingo-oophorectomy is generally considered optimal therapy for patients with uterine sarcomas. Local resection of the tumor or hysterectomy with ovarian conservation has been used in only a small number of patients. Recurrence risk in women undergoing ovarian-sparing surgery for müllerian adenosarcomas can be difficult to evaluate due to the paucity of literature in this area. We present a reproductive-age woman with a müllerian adenosarcoma and review the literature on conservative surgical management of this class of tumors.


METHODS
A 25-year-old nulligravida was diagnosed with a uterine adenosarcoma and the question of conservative surgical therapy arose. Following a literature review, discussion with the patient led to the decision for ovarian preservation at the time of hysterectomy. The pelvis and abdomen were grossly free of metastatic disease at laparotomy and all tumor was confined to the uterus on pathologic examination. She is free of disease 36 months postoperatively and is now considering in vitro fertilization using a surrogate.


CONCLUSIONS
Ovarian conservation can probably be offered safely in carefully selected women of reproductive age with müllerian adenosarcomas.
Michener
C M
CM
Department of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA. cm_md@yahoo.com
Simon
N L
NL
D018195:Adenosarcoma / Q000601:surgery*; D000328:Adult; D005260:Female; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000601:surgery*; D010053:Ovary / Q000601:surgery*; D014594:Uterine Neoplasms / Q000601:surgery*