Regulation of nucleocytoplasmic trafficking by cell adhesion receptors and the cytoskeleton.
It has become widely accepted that adhesion receptors can either directly activate, or significantly modulate, many of the signaling cascades initiated by circulating growth factors. An interesting recent development is the realization that adhesion receptors and their cytoskeletal partners can regulate the trafficking of signaling proteins between the cytoplasm and nucleus. Cell adhesion molecule control of nucleocytoplasmic trafficking allows adhesion to influence many cell decisions, and highlights the diversity of nuclear import and export mechanisms.
Aplin
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AE
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. aaplin@med.unc.edu
Juliano
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RL
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D003599:Cytoskeleton / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D015815:Cell Adhesion Molecules; D014157:Transcription Factors