[Cytotoxicity of the strontium-substituted hydroxyapatite evaluated by MTT colorimetry].
This study was conducted to evaluate the cytotoxicity of strontium-substituted hydroxyapatite by methyl thiazolyl tetrazolium (MTT) colorimetry. We used the MTT method to assay the cytotoxicity of the strontium-substituted hydroxyapatite containing different strontium concentrations (1%, 5%, 10%, 100% Sr2+) and the pure hydroxyapatite. The results showed that the cytotoxicity scores of the different materials were grade 0 or grade 1. These led us to the conclusion that strontium-substituted hydroxyapatite has good biocompatibility.
Fu
Y
Y
Department of Prosthetics, Affiliated Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011.
Chen
D
D
Zhang
J
J
D000818:Animals; D003124:Colorimetry; D003602:Cytotoxicity, Immunologic; D006882:Hydroxyapatites / Q000008:administration & dosage / Q000506:poisoning*; D066298:In Vitro Techniques; D051379:Mice; D013324:Strontium / Q000008:administration & dosage / Q000506:poisoning*; D013778:Tetrazolium Salts; D013844:Thiazoles
D006882:Hydroxyapatites; D013778:Tetrazolium Salts; D013844:Thiazoles; C076185:strontium hydroxyapatite; C022616:thiazolyl blue; D013324:Strontium