title: Interventional neurophysiology for pain control: duration of pain relief following repetitive transcranial magnetic stimulation of the motor cortex.
abstract: The chronic electrical stimulation of a motor cortical area corresponding to a painful region of the body, by means of surgically-implanted epidural electrodes is a validated therapeutical strategy to control medication-resistant neurogenic pain. Repetitive transcranial magnetic stimulation (rTMS) permits to stimulate non-invasively and precisely the motor cortex. We applied a 20-min session of rTMS of the motor cortex at 10 Hz using a 'real' or a 'sham' coil in a series of 14 patients with intractable pain due to thalamic stroke or trigeminal neuropathy. We studied the effects of rTMS on pain level assessed on a 0-10 visual analogue scale from day 1 to day 12 following the rTMS session. A significant pain decrease was observed up to 8 days after the 'real' rTMS session. This study shows that a transient pain relief can be induced in patients suffering from chronic neurogenic pain during about the week that follows a 20-min session of 10 Hz-rTMS applied over the motor cortex.
authors.affiliation: Service de physiologie-explorations fonctionnelles, hôpital Henri-Mondor, Inserm U421, faculté de médecine, 94010 Créteil, France. jean-pascal.lefaucheur@hmn.ap-hop-paris.fr
authors.forename: J P
authors.initials: JP
authors.lastname: Lefaucheur
authors.forename: X
authors.initials: X
authors.lastname: Drouot
authors.forename: J P
authors.initials: JP
authors.lastname: Nguyen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004599:Electric Stimulation Therapy / Q000009:adverse effects; D004567:Electrodes, Implanted; D004574:Electromagnetic Fields / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D010147:Pain Measurement; D010148:Intractable Pain / Q000209:etiology / Q000628:therapy*; D020521:Stroke / Q000150:complications; D013786:Thalamic Diseases / Q000150:complications; D020433:Trigeminal Nerve Diseases / Q000628:therapy