title: Midfacial osteomyelitis in a chronic cocaine abuser: a case report.
abstract: We describe the case of a 56-year-old man who was admitted for treatment of a progressive destruction of his hard palate, septum, nasal cartilage, and soft palate that had been caused by chronic cocaine inhalation. Biopsy of the bony septum revealed acute osteomyelitis and an extensive overgrowth of bacteria and Actinomyces-like organisms. There was no evidence of granuloma or neoplasm. The patient received intravenous ampicillin/sulbactam for 6 weeks, followed by lifetime oral amoxicillin. When there was no further evidence that destruction was progressing, the patient underwent nasal reconstruction with a cranial bone graft. The surgery was completed with no complications. To our knowledge, this is the first reported case of midfacial osteomyelitis associated with chronic cocaine abuse. The severity of this patient's complications, coupled with the success of his reconstructive surgery, makes this case particularly interesting. We believe that it is important for physicians to understand that septal perforation in a cocaine abuser should not be underestimated because it could result in a secondary bone infection. Nasoseptal destruction secondary to intranasal cocaine abuse is a result of cocaine's vasoconstrictive properties, and a decrease in the oxygen tension of intranasal tissue can facilitate the growth of anaerobic pathogens.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, Edwards Bldg., R-135, Stanford University Medical Center, Stanford, CA 94305-5328, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Talbott
authors.forename: G K
authors.initials: GK
authors.lastname: Gorti
authors.forename: R J
authors.initials: RJ
authors.lastname: Koch
mesh_terms: D000281:Administration, Intranasal; D019970:Cocaine-Related Disorders / Q000150:complications*; D006801:Humans; D008297:Male; D008439:Maxillary Diseases / Q000209:etiology*; D008875:Middle Aged; D009300:Nasal Septum / Q000473:pathology / Q000601:surgery; D009668:Nose Diseases / Q000139:chemically induced* / Q000601:surgery; D010019:Osteomyelitis / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D010159:Palate / Q000473:pathology; D019651:Plastic Surgery Procedures