Expression systems for use in actinomycetes and related organisms.
There have been significant advances in genetic and molecular approaches to understanding the physiology of organisms belonging to the genera Mycobacterium, Corynebacterium, Nocardia and Streptomyces. This review discusses recent advances in heterologous protein expression in members of the actinomycete group, including codon usage, post-translational modification and inducible gene expression.
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Department of Microbiology and Molecular Genetics, Ruy V Lourenco Center for Emerging and Re-emerging Pathogens, NJMS-National Tuberculosis Center, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA. connell@umdnj.edu
D000192:Actinomycetales / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000032:analysis*; D001435:Bacteriophages / Q000235:genetics; D003352:Corynebacterium / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D009161:Mycobacterium / Q000235:genetics; D009615:Nocardia / Q000235:genetics; D010957:Plasmids; D011401:Promoter Regions, Genetic; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000032:analysis / Q000096:biosynthesis; D013302:Streptomyces / Q000235:genetics; D015533:Transcriptional Activation
D001426:Bacterial Proteins; D011994:Recombinant Proteins