[Phenomenon of DNA-abzyme cross-reactivity and its significance for the mechanisms of cytotoxicity and apoptosis].
The physiological role of DNA-abzymes and their involvement in pathogenesis of different autoimmune disorders is still unknown. At the same time, a variety of properties and features of DNA-hydrolyzing autoantibodies have been studied. Here, the phenomenon of the cross-reactivity of DNA-abzymes with the nuclear matrix proteins was studied. The possible value of the phenomenon for the cytotoxic activity of DNA-hydrolyzing autoantibodies was debated as well. A new hypothesis is put forward regarding the DNA-abzymes formation based on the phenomenon of the cross-reactivity of polyclonal DNA-abzymes with nuclear matrix proteins free of native DNA. Preliminary results suggest that there are mechanisms of cytotoxicity mediated by DNA-abzymes and independent from the system of complement and cytotoxic T-lymphocytes.
Suchkov
S V
SV
Moscow District Research Clinical Institute (MONIKI), ul. Shchepkina 61/2, Moscow, 129110 Russia.
Gabibov
A G
AG
Gnuchev
N V
NV
D017151:Antibodies, Catalytic / Q000235:genetics* / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D002847:Chromatography, Agarose; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D004247:DNA / Q000276:immunology; D006801:Humans; D009687:Nuclear Proteins / Q000276:immunology / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D017151:Antibodies, Catalytic; D009687:Nuclear Proteins; D004247:DNA
Fenomen kross-reaktivnosti dnk-abzimov i ego znachenie dlia mekhanizmov tsitotoksichnosti i apoptoza.