Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta.
Two novel aplysinopsin-type indole alkaloids, 1 and 2, and three known indole alkaloids were isolated from the marine sponge Hyrtios erecta. These compounds exhibited selective inhibitory activity against the neuronal isozyme of nitric oxide synthase (nNOS). Furthermore, new quinolone 7 was also isolated from the same marine sponge. The chemical structures of these new compounds were elucidated on the basis of spectroscopic analysis.
Aoki
S
S
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Ye
Y
Y
Higuchi
K
K
Takashima
A
A
Tanaka
Y
Y
Kitagawa
I
I
Kobayashi
M
M
D000818:Animals; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology*; D019323:omega-N-Methylarginine / Q000494:pharmacology
D004791:Enzyme Inhibitors; D019323:omega-N-Methylarginine; C015685:aplysinopsin; D014364:Tryptophan; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; C496322:Nos1 protein, rat; C496318:Nos2 protein, rat