title: Lack of association between GABRA3 and unipolar affective disorder: a multicentre study.
abstract: Available data on gamma amino butyric acid (GABA) support the hypothesis that a dysfunction in the brain GABAergic system activity contributes to vulnerability to affective disorders (AD), including bipolar disorder (BPAD) and unipolar disorder (UPAD). The localization of the alpha3 subunit GABA receptor (GABRA3) gene in Xq28, a region of interest for BPAD suggests that GABRA3 may be a relevant candidate gene. In the present study, we tested the genetic contribution of the GABRA3 dinucleotide polymorphism in a European multicentre UPAD case-control sample [UPAD (n = 106), controls (n = 212)]. Our negative results suggest that GABRA3 does not confer susceptibility nor is it in linkage disequilibrium with another close gene involved in the genetic aetiology of UPAD.
authors.affiliation: Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, 808 route de Lennik, B-1070 Brussels, Belgium. imassat@ulb.ac.be
authors.forename: I
authors.initials: I
authors.lastname: Massat
authors.forename: D
authors.initials: D
authors.lastname: Souery
authors.forename: J
authors.initials: J
authors.lastname: Del-Favero
authors.forename: L
authors.initials: L
authors.lastname: Oruc
authors.forename: M
authors.initials: M
authors.lastname: Jakovljevic
authors.forename: V
authors.initials: V
authors.lastname: Folnegovic
authors.forename: R
authors.initials: R
authors.lastname: Adolfsson
authors.forename: R
authors.initials: R
authors.lastname: Kaneva
authors.forename: G
authors.initials: G
authors.lastname: Papadimitriou
authors.forename: D
authors.initials: D
authors.lastname: Dikeos
authors.forename: E
authors.initials: E
authors.lastname: Jazin
authors.forename: V
authors.initials: V
authors.lastname: Milanova
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: J
authors.initials: J
authors.lastname: Mendlewicz
mesh_terms: D000328:Adult; D000341:Affective Disorders, Psychotic / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D018079:Receptors, GABA / Q000235:genetics*
chemical_list: D018079:Receptors, GABA