Contribution of base lesions to radiation-induced clustered DNA damage: implication for models of radiation response.
Biophysical modeling of radiation-induced DNA damage shows that significant yields of clustered DNA damage are formed after energy deposition by a single radiation track. To date, the majority of studies on radiation-induced DNA damage in cells have concentrated on determination of the yields of single- and double-strand breaks (DSBs), the latter representing one type of clustered DNA damage. It was recognized, however, that clustered DNA damage, which does not contain a DSB, might contain a combination of DNA base lesions and single-strand breaks in proximity. This mini-review discusses some of the recent experimental data confirming the induction of non-DSB, clustered DNA damage by radiation.
Jenner
T J
TJ
MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxfordshire, OX11 0RD, United Kingdom.
Fulford
J
J
O'Neill
P
P
D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D004249:DNA Damage; D006801:Humans; D008954:Models, Biological; D010957:Plasmids / Q000235:genetics / Q000528:radiation effects; D011839:Radiation, Ionizing
D004247:DNA