Inhibition of histone deacetylase activity causes cell type-specific induction of the PDGF-B promoter only in the absence of activation by its enhancer.
D000230:Adenocarcinoma; D001943:Breast Neoplasms; D006528:Carcinoma, Hepatocellular; D002822:Choriocarcinoma; D002875:Chromosomes; D019175:DNA Methylation; D004742:Enhancer Elements, Genetic / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000502:physiology; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology; D007438:Introns; D008113:Liver Neoplasms; D016296:Mutagenesis / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000502:physiology*; D020574:Proto-Oncogene Proteins c-sis / Q000235:genetics*; D012208:Rhabdomyosarcoma; D014158:Transcription, Genetic / Q000187:drug effects / Q000502:physiology; D014407:Tumor Cells, Cultured