Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.
D000494:Allosteric Regulation; D017398:Alternative Splicing; D000818:Animals; D001921:Brain / Q000166:cytology / Q000648:ultrastructure; D016466:CHO Cells; D020013:Calcium Signaling / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D006224:Cricetinae; D018755:GABA Agonists / Q000494:pharmacology*; D058786:GABA-B Receptor Agonists; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D018080:Receptors, GABA-B / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism