Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2.
D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D014450:Electron Transport Complex III / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015151:Immunoblotting; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D013347:Subcellular Fractions; D051028:bcl-2-Associated X Protein