Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002352:Carrier Proteins / Q000096:biosynthesis; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000378:metabolism; D004347:Drug Interactions; D004579:Electron Transport / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects*; D006861:Hydrogen Peroxide / Q000378:metabolism* / Q000494:pharmacology; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000235:genetics; D007371:Interferon-gamma / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D053613:Janus Kinase 1; D053614:Janus Kinase 2; D007700:Kinetics; D008713:Methimazole / Q000494:pharmacology*; D010544:Peroxidases / Q000494:pharmacology; D054464:Peroxiredoxins; D010766:Phosphorylation / Q000187:drug effects; D014176:Protein Biosynthesis; D050828:Protein Inhibitors of Activated STAT; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011506:Proteins; D011518:Proto-Oncogene Proteins; D051381:Rats; D012097:Repressor Proteins; D050794:STAT1 Transcription Factor; D050796:STAT3 Transcription Factor; D015398:Signal Transduction / Q000502:physiology; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors; D014443:Tyrosine / Q000378:metabolism