Point mutations identify the glutamate binding pocket of the N-methyl-D-aspartate receptor as major site of conantokin-G inhibition.
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics; D000818:Animals; D001667:Binding, Competitive / Q000235:genetics; D020916:Conotoxins / Q000378:metabolism* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D018691:Excitatory Amino Acid Antagonists / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D008969:Molecular Sequence Data; D008978:Mollusk Venoms / Q000378:metabolism* / Q000494:pharmacology; D016297:Mutagenesis, Site-Directed; D017354:Point Mutation; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D014981:Xenopus