A hypoallergenic derivative of the major allergen of the dust mite Lepidoglyphus destructor, Lep d 2.6Cys, induces less IgE reactivity and cellular response in the skin than recombinant Lep d 2.
D000328:Adult; D000485:Allergens / Q000235:genetics / Q000276:immunology*; D000818:Animals; D016022:Case-Control Studies; D004804:Eosinophils / Q000276:immunology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000096:biosynthesis; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D008925:Mites / Q000235:genetics / Q000276:immunology*; D016297:Mutagenesis, Site-Directed; D011506:Proteins / Q000235:genetics / Q000276:immunology*; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D012867:Skin / Q000276:immunology; D012882:Skin Tests