Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.
D000236:Adenoma / Q000139:chemically induced / Q000235:genetics; D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000008:administration & dosage; D002277:Carcinoma / Q000139:chemically induced / Q000235:genetics; D003433:Crosses, Genetic; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D005260:Female; D011905:Genes, ras / Q000187:drug effects / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D008175:Lung Neoplasms / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D016212:Transforming Growth Factor beta / Q000172:deficiency / Q000235:genetics*; D053773:Transforming Growth Factor beta1; D014520:Urethane / Q000008:administration & dosage