Mpl ligand increases P2Y1 receptor gene expression in megakaryocytes with no concomitant change in platelet response to ADP.
D000244:Adenosine Diphosphate / Q000378:metabolism*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D017403:In Situ Hybridization; D008533:Megakaryocytes / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D020871:RNA Stability / Q000187:drug effects; D012333:RNA, Messenger / Q000096:biosynthesis / Q000187:drug effects; D018048:Receptors, Purinergic P2 / Q000096:biosynthesis / Q000235:genetics*; D058472:Receptors, Purinergic P2Y1; D011994:Recombinant Proteins / Q000494:pharmacology; D013926:Thrombopoietin / Q000737:chemistry / Q000494:pharmacology*; D015854:Up-Regulation