Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis.
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D017209:Apoptosis; D016203:CDC2 Protein Kinase / Q000037:antagonists & inhibitors; D002455:Cell Division; D002478:Cells, Cultured; D019926:Cyclin B / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins; D005347:Fibroblasts / Q000166:cytology / Q000201:enzymology; D016195:G2 Phase; D017353:Gene Deletion; D005822:Genetic Vectors; D006801:Humans; D051379:Mice; D008938:Mitosis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D011494:Protein Kinases / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology*; D014162:Transfection; D014407:Tumor Cells, Cultured