Mutation of the 9' leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states.
D019943:Amino Acid Substitution / Q000235:genetics* / Q000502:physiology; D000818:Animals; D002460:Cell Line; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D007930:Leucine / Q000235:genetics* / Q000502:physiology; D018408:Patch-Clamp Techniques; D017354:Point Mutation; D051381:Rats; D011963:Receptors, GABA-A / Q000235:genetics* / Q000502:physiology; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology