Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes.
D004247:DNA / Q000737:chemistry / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D054856:G-Quadruplexes; D006801:Humans; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014407:Tumor Cells, Cultured