Regulated expression of human filaggrin in keratinocytes results in cytoskeletal disruption, loss of cell-cell adhesion, and cell cycle arrest.
D022005:Adherens Junctions / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017209:Apoptosis / Q000502:physiology; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002460:Cell Line; D048429:Cell Size / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000378:metabolism; D003599:Cytoskeleton / Q000502:physiology* / Q000648:ultrastructure; D051182:Desmogleins; D051180:Desmoplakins; D003896:Desmosomes / Q000378:metabolism; D000078404:Epidermal Cells; D000091344:Filaggrin Proteins; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007381:Intermediate Filament Proteins / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*; D007382:Intermediate Filaments / Q000378:metabolism; D015603:Keratinocytes / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D007633:Keratins / Q000378:metabolism; D016253:Microscopy, Immunoelectron; D051381:Rats; D013752:Tetracycline / Q000494:pharmacology; D014746:Vimentin / Q000235:genetics / Q000378:metabolism; D051185:gamma Catenin