N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D020552:Comet Assay; D004247:DNA / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D053938:DNA Fragmentation / Q000187:drug effects; D004128:Dimethylnitrosamine / Q000378:metabolism* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000378:metabolism; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000378:metabolism / Q000633:toxicity; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley