Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcription of nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells.
D002460:Cell Line; D016207:Cytokines / Q000494:pharmacology*; D017930:Genes, Reporter; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D020929:Mitogen-Activated Protein Kinase Kinases / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D009154:Mutation; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000502:physiology*; D015533:Transcriptional Activation; D014162:Transfection; D014407:Tumor Cells, Cultured; D020830:rac1 GTP-Binding Protein / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000502:physiology*; D020742:rhoA GTP-Binding Protein / Q000502:physiology; D020743:rhoB GTP-Binding Protein / Q000502:physiology