Enantioseparation of linear and cyclic chiral bis(phenethyl)amines by means of cyclodextrin-modified capillary electrophoresis.
For two years drugs introduced to the market have had- to be enantiomerically pure. Rapid and cheap methods of high reproducibility must, therefore, be available for evaluation of enantiomeric purity. Within the framework of a larger project dealing with chiral recognition of phenethylamines by means of native and derivatized cyclodextrins it was intended to find capillary electrophoresis methods suitable for separation of the enantiomers of chiral bis(phenethyl)amines and their corresponding cyclic analogues, within 10 min, using small amounts of a chiral selector, to save time and money. Heptakis(2,3-O-diacetyl-6-sulfato)beta-CD was found to be the most promising candidate most often fulfilling these requirements.
Wedig
M
M
Institute of Pharmacy and Food Chemistry, University of Würzburg, Germany.
Thunhorst
M
M
Laug
S
S
Decker
M
M
Lehmann
J
J
Holzgrabe
U
U
D003505:Cyclodextrins / Q000737:chemistry* / Q000592:standards; D019075:Electrophoresis, Capillary; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification; D010627:Phenethylamines / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
D003505:Cyclodextrins; D004364:Pharmaceutical Preparations; D010627:Phenethylamines