title: Synthesis, ligand pK(a), and Fe(III) complexation constants for a series of bipodal dihydroxamic acids.
abstract: The synthesis of four bipodal dihydroxamic acids containing an apical C atom and amide linkages is described, where Ia,b represent "normal" and "retro" hydroxamate isomers: (R)CH[C(=O)NH(CH(2))(2)NHC(=O)(CH(2))(n)()R'](2) (Ia, R = CH(3), R' = N(OH)(C=O)CH(3), n = 2; Ib, R = CH(3), R' = (C=O)N(OH)CH(3), n = 2; Ic, R = CH(3), R' = (C=O)N(OH)CH(3), n = 3; Id, R = C(4)H(9), R' = (C=O)N(OH)CH(3), n = 2.). The pK(a1) and pK(a2) values in aqueous solution are reported, and some degree of cooperativity is noted. Complexation equilibria with Fe(aq)(3+) are described, and values for stepwise and overall equilibrium constants are reported. log beta(230) values for Ia-d are 59.22, 59.45, 58.91, and 58.46, slightly lower than for rhodotorulic acid, although the pFe values for the synthetic siderophores are comparable to that for rhodotorulic acid.
authors.affiliation: Laboratoire de Chimie Bioorganique et Bioinorganique, CNRS-ERS 1824, ICMO, Université de Paris-SUD, Bat 420, 91405, Orsay, France.
authors.forename: M K
authors.initials: MK
authors.lastname: Nguyen-Van-Duong
authors.forename: V
authors.initials: V
authors.lastname: Guillot
authors.forename: L
authors.initials: L
authors.lastname: Nicolas
authors.forename: A
authors.initials: A
authors.lastname: Gaudemer
authors.forename: L
authors.initials: L
authors.lastname: Lowry
authors.forename: I
authors.initials: I
authors.lastname: Spasojević
authors.forename: A L
authors.initials: AL
authors.lastname: Crumbliss