title: Cytotoxic cyclic norterpene peroxides from a Red Sea sponge Diacarnus erythraenus.
abstract: Investigation of the lipophilic extract of the Red Sea sponge Diacarnus erythraenus revealed one new norsesterterpene cyclic peroxide, aikupikoxide A (1), three new norditerpene cyclic peroxides, aikupikoxide B-D (2-4), and the known norterpene peroxides muqubilin and nuapapuin A methyl ester. In addition, a new sesquiterpene, O-methyl guaianediol, was isolated. Their structures were determined by means of spectroscopic methods. The cytotoxic activities for the isolated compounds have been reported.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
authors.forename: D T
authors.initials: DT
authors.lastname: Youssef
authors.forename: W Y
authors.initials: WY
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Kelly
authors.forename: P J
authors.initials: PJ
authors.lastname: Scheuer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D004534:Egypt; D006801:Humans; D019156:Indian Ocean; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D008175:Lung Neoplasms; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; C440682:O-methylguaianediol; D010545:Peroxides; D012717:Sesquiterpenes; D013729:Terpenes; C440678:aikupikoxide A; C440679:aikupikoxide B; C440680:aikupikoxide C; C440681:aikupikoxide D