Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways.
Cell cycle progression in mammalian cells is strictly regulated by both integrin-mediated adhesion to the extracellular matrix and by binding of growth factors to their receptors. This regulation is mediated by G1 phase cyclin-dependent kinases (CDKs), which are downstream of signaling pathways under the integrated control of both integrins and growth factor receptors. Recent advances demonstrate a surprisingly diverse array of integrin-dependent signals that are channeled into the regulation of the G1 phase CDKs. Regulation of cyclin D1 by the ERK pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression.
Schwartz
M A
MA
Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. schwartz@scripps.edu
Assoian
R K
RK
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D003593:Cytoplasm / Q000201:enzymology; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008322:Mammals; D015398:Signal Transduction / Q000502:physiology*
D016023:Integrins; D018844:Cyclin-Dependent Kinases