S-adenosyl-L-methionine N-ole-1-oyltaurate: pharmacokinetic of the orally administered salt in rats.
A pharmacokinetic study based on the distribution of radioactivity from the double labelled S-adenosyl-L-methionine (SAM) has been carried out by oral administration of the liposoluble stable salt [methyl-(14)C, 8-(3)H]SAM N-ole-1-oyltaurate to rats. The SAM sulfate p-toluensulfonate salt, the only SAM salt at present commercialized as drug, was chosen as reference compound to have a comparative pharmacokinetic analysis. The metabolism of the SAM is characterised by a differential use of the two labelled moieties by the various organs, liver being the most active in metabolizing the sulfonium compound with a preferential uptake of the methyl-(14)C fragment. The radioactivity detected after the administration of [methyl-(14)C, 8-(3)H]SAM N-ole-1-oyltaurate is, in all the organs examined, two times higher than the [methyl-(14)C, 8-(3)H]SAM sulfate p-toluensulfonate compound, attesting that the liposoluble [methyl-(14)C, 8-(3)H]SAM N-ole-1-oyltaurate is provided with better bioavailability.
Morana
A
A
Istituto di Scienze dell' Alimentazione, CNR, via Roma 52 A/C, 83100 Avellino, Italy. amorana10@libero.it
De Rosa
A
A
Cartenì
M
M
Parlato
M
M
De Rosa
M
M
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D009829:Oleic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012436:S-Adenosylmethionine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D009829:Oleic Acids; C443599:S-adenosyl-L-methionine N-ole-1-oyltaurate; D013654:Taurine; D012436:S-Adenosylmethionine