[Pulmonary repair after adult respiratory distress syndrome].
The adult respiratory distress syndrome (ARDS) represents a particulary dangerous form of acute respiratory failure. The processes of reparation of the lungs start in the course of several hours following the acute pulmonary damage and ARDS. They imply: 1) lysis of intraalveolar fibrin, phagocytosis of the necrotic products and resorption of the edematous fluid from the alveolar lumen and the pulmonary interstitium. 2) reparation of the pneumocytes and the bronchiolar Clara cells. 3) reparation of the pulmonary interstitium (pulmonary fibrosis and sclerosis). These processes of reparation in the lung are modulated by cell adhesion molecules of the integrin group and a number of growth factors (PDGF, AMDGF, EGF, FGF, IGF-I). Apoptosis is the main factor that controls the correct outcome of the processes of pulmonary reparation.
Lazarov
S
S
Balutsov
M
M
Ianev
E
E
D000328:Adult; D017209:Apoptosis / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D011658:Pulmonary Fibrosis / Q000150:complications / Q000473:pathology*; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000209:etiology / Q000503:physiopathology*
D015815:Cell Adhesion Molecules; D006133:Growth Substances; D016023:Integrins