Pattern of malignant lymphoma in the United Arab Emirates--a histopathologic and immunologic study in 208 native patients.
The aim of this study was to analyze the distribution of the various pathologic types of lymphoma in a native Arab population of the United Arab Emirates (UAE). Two hundred and eight patients with malignant lymphoma diagnosed over a 12-year period (1988-1999) were retrospectively studied morphologically and immunohistochemically with a panel of monoclonal antibodies and classified according to the revised European-American classification of lymphoid neoplasms (REAL). Of the 208 patients in the study, 41% had Hodgkin's disease (HD) and 59% had non-Hodgkin's lymphoma (NHL). The distribution of HD showed a predominance of nodular sclerosis and mixed cellularity types. Among NHLs, the most frequent type was diffuse large B cell (59% of all NHLs) followed by the Burkitt's type (13%). The proportion of primary extranodal NHL was 29%. Immunologically, the percentages of NHL with B-cell and T-cell phenotypes were 83 and 11, respectively. When the International Working Formulation was used, 34% of NHLs were classified as high grade, 59% as intermediate grade and only 7% as low-grade lymphomas.
Castella
A
A
Faculty of Medicine, Pathology Department, UAE University, Al Ain, United Arab Emirates. acastella@uaeu.ac.ae
Joshi
S
S
Raaschou
T
T
Mason
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D018912:Arabs; D001402:B-Lymphocytes / Q000737:chemistry / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000145:classification / Q000208:ethnology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000737:chemistry / Q000145:classification / Q000208:ethnology* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000737:chemistry / Q000145:classification / Q000208:ethnology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000737:chemistry / Q000473:pathology; D014479:United Arab Emirates / Q000453:epidemiology
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2