title: Tumor characteristics in African American and white women.
abstract: BACKGROUND
  Previous studies provide evidence that breast cancers occurring in different age and ethnic groups are not evenly distributed with regard to their biologic, pathologic and clinical characteristics. We evaluated the distributions of 11 pathological and biological variables between African-American (AA) and white patients and between three different age groups (20-39, 40-59 and 60-74 years). We examined whether racial differences existed across levels of age.
  
  
  METHODS
  Data were obtained from the Carolina Breast Cancer Study (CBCS), a population-based, case-control study of breast cancer in North Carolina. Eighty hundred and sixty one women with a first diagnosis of invasive breast cancer participated in Phase I of the CBCS. Diagnostic paraffin blocks were obtained from 807 cases. One representative block was scored for histologic type and grade (architectural, nuclear, mitotic and overall). Medical chart review yielded tumor size, lymph node status, distant metastases, stage, hormone receptor status (ER/PR) and DNA ploidy.
  
  
  RESULTS
  Pathologically advanced tumors (large size, high grade, high stage, ER/PR negative) were significantly more common in young and AA women. Racial differences varied by age. Among younger, AAs and whites differed only with respect to ER/PR status, while among older women AAs and whites differed only with respect to stage at diagnosis.
  
  
  CONCLUSIONS
  The results of this study confirm the presence of poorer prognosis breast cancer among AA and younger women. They also highlight the need for age and race to be considered together when evaluating pathologic and biologic characteristics of disease and when making inferences regarding tumor aggressiveness.
authors.affiliation: Department of Epidemiology, School of Public Health, University of North Carolina Chapel Hill, USA. helena.furberg@mssm.edu
authors.forename: H
authors.initials: H
authors.lastname: Furberg
authors.forename: R
authors.initials: R
authors.lastname: Millikan
authors.forename: L
authors.initials: L
authors.lastname: Dressler
authors.forename: B
authors.initials: B
authors.lastname: Newman
authors.forename: J
authors.initials: J
authors.lastname: Geradts
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D044383:Black People / Q000235:genetics*; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D008499:Medical Records; D008875:Middle Aged; D009367:Neoplasm Staging; D009376:Neoplasms, Hormone-Dependent / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D009657:North Carolina / Q000453:epidemiology; D012307:Risk Factors; D044465:White People / Q000235:genetics*; D016387:Women's Health; D001741:Black or African American