[Cutaneous manifestations of B-CLL masked by florid epithelioid granulomatous response].
We report an unusual case of iterative cutaneous manifestations of B-cell chronic lymphocytic leukaemia, masked by a florid epithelioid granulomatous response. These cutaneous lesions appeared without blood hyperlymphocytosis or lymph node enlargement. The diagnosis of cutaneous tumorous infiltrates was morphologically very difficult and required immunohistochemistry as well as PCR. This observation stresses the diagnostic difficulties encountered in lymphoma, with intense stroma reaction and the need for complementary techniques to reach the right diagnosis and thus deliver appropriate therapy.
Jourdan
F
F
Service d'Anatomie et de Cytologie Pathologiques, Hotel Dieu, Ap-HP, 1 Place du Parvis Notre Dame 75818 Paris Cedex, France.
Molina
T
T
Rigau
V
V
Le Tourneau
A
A
Diebold
J
J
Marie
J P
JP
Audouin
J
J
D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D001706:Biopsy; D018956:CD5 Antigens / Q000032:analysis; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006099:Granuloma / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000473:pathology*; D016133:Polymerase Chain Reaction; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000150:complications / Q000473:pathology
D018951:Antigens, CD20; D018956:CD5 Antigens