Gangliosides for acute ischaemic stroke.
BACKGROUND
Gangliosides may have a protective effect on the central and peripheral nervous systems.


OBJECTIVE
The objective of this review was to assess the effect of exogenous gangliosides in acute ischaemic stroke.


METHODS
We searched the Cochrane Stroke Group trials register (last searched: May 2001) and contacted drug companies and main investigators of included trials.


METHODS
Randomised trials of gangliosides compared with placebo or standard treatment in people with definite or presumed ischaemic stroke. Trials were included if people were randomised within 15 days of symptom onset and if mortality data were available.


METHODS
One reviewer applied the inclusion criteria. Two reviewers independently extracted the data. Trial quality was assessed.


RESULTS
Twelve trials involving 2265 people were included. All the trials tested purified monosialoganglioside GM1. Only three trials described the randomisation procedure. Follow-up was between 15 to 180 days. Death at the end of follow-up showed no significant difference (odds ratio 0.91, 95% confidence interval 0.73 to 1.13). There was no difference shown between early (within 48 hours) and delayed treatment. For disability, three trials did not show any improvement in Barthel index score with gangliosides (weighted mean difference 2.1; 95% confidence interval -4.8 to 8.9). In two trials, eight patients experienced adverse effects that led to discontinuation of ganglioside treatment, seven had skin reactions and one developed Guillain-Barré syndrome.


CONCLUSIONS
There is not enough evidence to conclude that gangliosides are beneficial in acute stroke. Caution is warranted because of reports of sporadic cases of Guillain-Barré syndrome after ganglioside therapy.
Candelise
L
L
Istituto di Clinica Neurologica, Università degli Studi di Milano, IRCCS Ospedale Policlinico, Via F. Sforza 35, Milano, Italy, 20122. livia.candelise@unimi.it
Ciccone
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D000208:Acute Disease; D002545:Brain Ischemia / Q000188:drug therapy; D005677:G(M1) Ganglioside / Q000627:therapeutic use; D005732:Gangliosides / Q000627:therapeutic use*; D006801:Humans; D020521:Stroke / Q000188:drug therapy*
D005732:Gangliosides; D005677:G(M1) Ganglioside