title: Mother-to-child discordance in HLA-G exon 2 is associated with a reduced risk of perinatal HIV-1 transmission.
abstract: Definitive genetic parameters correlating with mother-to-child transmission (MCT) of HIV have not been fully established. We screened for the potential correlation between HLA-G variants and MCT, in a cohort of mother-child pairs. Discordance in exon 2 of HLA-G was significantly more common among non-transmitting (93%) than transmitting mother-child pairs (40%). Our results suggest that mother-child pairs both carrying the identical mutation in HLA-G exon 2 may be at higher risk of MCT of HIV-1.
authors.affiliation: Department of Microbiology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
authors.forename: F O
authors.initials: FO
authors.lastname: Aikhionbare
authors.forename: T
authors.initials: T
authors.lastname: Hodge
authors.forename: L
authors.initials: L
authors.lastname: Kuhn
authors.forename: M
authors.initials: M
authors.lastname: Bulterys
authors.forename: E J
authors.initials: EJ
authors.lastname: Abrams
authors.forename: V C
authors.initials: VC
authors.lastname: Bond
mesh_terms: D004279:DNA, Viral / Q000097:blood; D005091:Exons / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D009154:Mutation; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I