title: A Versatile Route to 2-Substituted Cyclic 1,3-Dienes via a Copper(I)-Catalyzed Cross-Coupling Reaction of Dienyl Triflates with Grignard Reagents.
abstract: A general synthesis of 2-substituted cyclic 1,3-dienes in two steps from alpha,beta-unsaturated ketones has been developed. Formation of a dien-2-yl triflate followed by a copper(I)-catalyzed cross-coupling reaction with a Grignard reagent gives 2-substituted dienes in fair to excellent yields. Alkyl, aryl, and allyl Grignard reagents can be used.
authors.affiliation: Department of Organic Chemistry, University of Uppsala, Box 531, SE-751 21 Uppsala, Sweden.
authors.forename: A. Sofia E.
authors.initials: AS
authors.lastname: Karlström
authors.forename: Magnus
authors.initials: M
authors.lastname: Rönn
authors.forename: Atli
authors.initials: A
authors.lastname: Thorarensen
authors.forename: Jan-E.
authors.initials: JE
authors.lastname: Bäckvall