Estimating the extent of the health hazard posed by high-production volume chemicals.
We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less than expected proportion of toxic chemicals among the HPV sample when compared to a reference set of 10,000 chemicals representative of the universe of chemicals.
Cunningham
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Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA. acunningham@server.ceoh.pitt.edu
Rosenkranz
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D002617:Chemical Industry; D005544:Forecasting; D015386:Hazardous Substances / Q000009:adverse effects*; D006801:Humans; D011634:Public Health; D012016:Reference Values; D018570:Risk Assessment; D013329:Structure-Activity Relationship; D018675:Toxicity Tests; D015262:Xenobiotics / Q000009:adverse effects*
D015386:Hazardous Substances; D015262:Xenobiotics