title: Recurrent arch obstruction after repair of isolated coarctation of the aorta in neonates and young infants: is low weight a risk factor?
abstract: BACKGROUND
  Repair of aortic coarctation is often delayed in small infants because of the belief that such patients are at risk of recurrent arch obstruction and that growth will decrease this risk. To determine whether low weight was a risk factor for recurrent arch obstruction, we reviewed our experience with coarctation repair via left thoracotomy in infants less than 3 months of age.
  
  
  METHODS
  From 1990 to 1999, 103 patients less than 3 months of age underwent repair of aortic coarctation through a left thoracotomy. Median age was 18 days (1-90 days), with 45 patients less than 2 weeks. Median weight was 3.3 kg (1.0-6.4 kg) and 14 patients were less than 2 kg. The method of repair was resection and end-to-end anastomosis in 64 patients, subclavian flap angioplasty in 34, and patch augmentation of the arch in 5. Demographic, echocardiographic, and operative variables were analyzed for correlation with recurrent arch obstruction.
  
  
  RESULTS
  One early and 1 late death occurred, both in patients who had complications but no evidence of recoarctation. At median follow-up of 24 months, reinterventions for recurrent arch obstruction were performed in 15 patients. The median time to reintervention was 5 months and was less than 1 year in 12 patients. Kaplan-Meier freedom from arch reintervention was 88% at 1 year (95% confidence intervals: 82%-94%) and 82% at 5 years (95% confidence intervals: 72%-92%). Factors associated with shorter duration to arch reintervention by univariable Cox regression included younger age (continuous, P =.01; <2 weeks, P =.005), smaller transverse arch (absolute diameter, P <.001; indexed to weight, P =.03; indexed to ascending aortic diameter, P =.02), and smaller ascending aorta (absolute diameter, P =.02). Smaller absolute transverse arch diameter and younger age were the only independent predictors of shorter time to arch reintervention by multivariable Cox regression analysis. Weight and type of repair did not correlate with risk of recoarctation.
  
  
  CONCLUSIONS
  Low weight is not a risk factor for recurrent obstruction after repair of coarctation of the aorta in infants less than 3 months of age. Rather, risk of recoarctation is more a function of the anatomy of the arch. Thus, it is not indicated to delay repair in low weight infants with the goal of achieving growth.
authors.affiliation: Division of Pediatric Cardiothoracic Surgery, The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: McElhinney
authors.forename: S G
authors.initials: SG
authors.lastname: Yang
authors.forename: A N
authors.initials: AN
authors.lastname: Hogarty
authors.forename: J
authors.initials: J
authors.lastname: Rychik
authors.forename: M M
authors.initials: MM
authors.lastname: Gleason
authors.forename: C H
authors.initials: CH
authors.lastname: Zachary
authors.forename: J J
authors.initials: JJ
authors.lastname: Rome
authors.forename: T R
authors.initials: TR
authors.lastname: Karl
authors.forename: W M
authors.initials: WM
authors.lastname: Decampli
authors.forename: T L
authors.initials: TL
authors.lastname: Spray
authors.forename: J W
authors.initials: JW
authors.lastname: Gaynor
mesh_terms: D001015:Aortic Arch Syndromes / Q000453:epidemiology*; D001017:Aortic Coarctation / Q000453:epidemiology / Q000601:surgery*; D001835:Body Weight; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012008:Recurrence; D012044:Regression Analysis; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D013908:Thoracotomy; D013997:Time Factors