Stereoselective Modification of a Cyclopentapeptide via an alpha-(Ethylthio)glycine Residue.
The solid-phase synthesis of cyclo[Val-D-Gly(SEt)-Pro-Phe-D-Ala] (5) on Kaiser's oxime resin is described. Conversion of 5 to the reactive alpha-chloroglycine derivative 9 allowed the stereoselective addition of thiols, alcohols, amines and other nucleophiles with formation of the modified cyclopeptides 11a-n.
Paulitz
Christian
C
Institut für Organische Chemie der Universität München Karlstrasse 23, D-80333 München, Germany.
Steglich
Wolfgang
W