From exposure to effect: a comparison of modeling approaches to chemical carcinogenesis.
Standardized long-term carcinogenicity tests aim to reveal the relationship between exposure to a chemical and occurrence of a carcinogenic response. The analysis of such tests may be facilitated by the use of mathematical models. To what extent current models actually achieve this purpose is difficult to evaluate. Various aspects of chemically induced carcinogenesis are treated by different modeling approaches, which proceed very much in isolation of each other. With this paper we aim to provide for the non-mathematician a comprehensive and critical overview of models dealing with processes involved in chemical carcinogenesis. We cover the entire process of carcinogenesis, from exposure to effect. We succinctly summarize the biology underlying the models and emphasize the relationship between model assumptions and model formulations. The use of mathematics is restricted as far as possible with some additional information relegated to boxes.
van Leeuwen
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IM
Department of Theoretical Biology, Faculty of Biology, Institute of Ecological Science, Vrije Universiteit, De Boelelaan 1087, 1081 HV, Amsterdam, The Netherlands. ingeborg@bio.vu.nl
Zonneveld
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C
D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods / Q000706:statistics & numerical data; D002273:Carcinogens / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D016015:Logistic Models; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced / Q000503:physiopathology
D002273:Carcinogens