Response of metastatic epidermoid anal cancer to single agent irinotecan: a case report.
We report a case of a patient affected by epidermoid anal cancer who had hepatic progression after standard therapy with the Nigro regimen (fluorouracil and mitomycin C plus radiotherapy). This is an uncommon neoplasm against which only few chemotherapeutic agents have been tested. In our patient salvage treatment with low dose irinotecan resulted in a partial response.
Grifaichi
F
F
Department of Experimental Medicine, University La Sapienza, Policlinico Umberto I, Rome, Italy.
Padovani
A
A
Romeo
F
F
Trinca
C
C
Moscetti
L
L
Cortesi
E
E
D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000556:secondary; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008875:Middle Aged; D016896:Treatment Outcome
D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin