title: Synthesis, Structure, and Reactivity of Enediyne Macrocycles.
abstract: The reaction of bis-propargyl bromide enediyne 4 with weakly basic nucleophiles allows the facile synthesis of acyclic and macrocyclic enediynes. Depending on the bis-nucleophile employed, 12- to 16-membered enediyne macrocycles were obtained. The thermal stability of the new cyclic enediynes was investigated by differential scanning calorimetry. Upon coordination of the macrocycle 5c with Hg(O(2)CCF(3))(2), a drop of the enediyne cyclization temperature of nearly 100 K was observed.
authors.affiliation: Institut für Biochemie der Martin-Luther-Universität Halle, D-06099 Halle, Germany.
authors.forename: Burkhard
authors.initials: B
authors.lastname: König
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Pitsch
authors.forename: Iris
authors.initials: I
authors.lastname: Thondorf