Anti-inflammatory effects of theophylline: modulation of immune functions during murine leukemia virus infection.
LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL/6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Thl cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment.
Liang
B
B
College of Public Health and School of Medicine, University of Arizona, Tucson 85724, USA.
Jiang
S
S
Zhang
Z
Z
Inserra
P
P
Lee
J
J
Solkoff
D
D
Watson
R R
RR
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D012192:Retroviridae Infections / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013806:Theophylline / Q000494:pharmacology*; D014412:Tumor Virus Infections / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D013806:Theophylline