Prophylactic actions of the antioxidant agent AEKOL on behavioral (psychoemotional) disturbances induced by chronic stress in rats.
The studies reported here provide the first evidence that the antioxidant preparation Aekol, which contains a mixture of vitamins A, E, and K3, has antidepressant properties and prophylactic actions in relation to behavioral (psychoemotional) disturbances induced in rats by chronic stress (neuroticization). The behavioral disturbances consisted of a state of depressivity, accompanied by increased anxiety, elimination of individual differences in behavior, and weakening of the relationships between behavioral measures, and these were recorded in the same animals in three different behavioral tests (open field test, forced swimming test, and light-dark selection test).
Sarkisova KYu
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Kulikov
M A
MA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002908:Chronic Disease; D003624:Darkness; D004338:Drug Combinations; D004644:Emotions / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects; D008027:Light; D008297:Male; D010775:Photic Stimulation; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000523:psychology*; D013550:Swimming / Q000523:psychology; D014801:Vitamin A / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*; D014812:Vitamin K / Q000494:pharmacology*
D000975:Antioxidants; D004338:Drug Combinations; D014801:Vitamin A; D014812:Vitamin K; D014810:Vitamin E