title: Spontaneous closure of ventricular septal defects in the first year of life.
abstract: OBJECTIVE
  The recent increase in the prevalence of ventricular septal defect (VSD) has been ascribed to the improved detection of small defects with echocardiography and the wider use of screening. The aim of this study was to determine the prevalence and timing of spontaneous closure of specific types of VSD in neonates using echocardiographic screening and follow-up.
  
  
  METHODS
  Two-dimensional color Doppler echocardiography was performed in 3,472 clinically normal full-term neonates born at Cathay General Hospital to detect isolated VSD. The relative prevalence of muscular versus perimembranous defects and their outcome in the first year of life were evaluated.
  
  
  RESULTS
  VSD was found in 74 neonates (34 male, 40 female), resulting in a prevalence of 21.3/1,000 live births. There were 48 muscular, 25 perimembranous, and one subpulmonic defects. Of the 74 patients, 11 were lost to follow-up. Within the observation period of 12 months, spontaneous closure occurred in 40 patients in the muscular group and in six patients in the perimembranous group. The overall rate of spontaneous closure was 73% by the end of the first year. Only five patients with perimembranous defects received digoxin therapy.
  
  
  CONCLUSIONS
  The prevalence of VSD in this series of neonates was 21.3/1,000 live births. The most common location of VSD in the neonatal period was in the region of the muscular septum. Muscular defects were more likely to close spontaneously than perimembranous defects. Most muscular defects underwent spontaneous closure during the 12-month follow-up period.
authors.affiliation: Department of Pediatrics, Cathay General Hospital, 360, Section 2, Nei-Hu Road, Taipei, Taiwan.
authors.forename: M H
authors.initials: MH
authors.lastname: Lin
authors.forename: N K
authors.initials: NK
authors.lastname: Wang
authors.forename: K L
authors.initials: KL
authors.lastname: Hung
authors.forename: C T
authors.initials: CT
authors.lastname: Shen
mesh_terms: D000367:Age Factors; D018618:Echocardiography, Doppler, Color; D005260:Female; D005500:Follow-Up Studies; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence