title: [Preliminary study of human Herpesvirus type 8 infection in pregnant women in Dakar (Senegal)].
abstract: HHV8 was discovered in 1994 and few studies on this virus have been conducted in Africa. The virus is related to Kaposi sarcoma, an opportunistic affection occurring during HIV infection. No studies have been carried out on this subject in Senegal, a country known for its low KS prevalence even among people living with HIV/AIDS. Thus it will be interesting to explore this field. The aim of our study has been first, to demonstrate the presence of HHV8; second, to evaluate sero-prevalence of the infection in Senegal and third, to determine the specificities of HHV8 infection in our country. We performed our study on 407 pregnant women whose average age was 29.24 years, the majority of whom were Senegalese. HIV serology was done by dot blot for the screening and western blot for the confirmation. For the diagnosis of HHV8 infection, we used the indirect immunofluorescence kit of ABI. HIV infection was low among this study population; 0.5% and no HIV1 infection was mentioned. Among the 407 women, 58 or 14.3% were HHV8 positive and there was no HHV8/HIVco-infection. Regarding marital status, no significant difference was found between HHV8 positive and HHV8 negative among unmarried, monogamous or polygamous women. However, women having had 4 to 5 children were more likely to test positive for HHV8. The difference is significant and a relationship has been established with a p value of 0.02. Regarding pregnancy, HHV8 infection is more closely related to abortion: 17.2% of women who had aborted were HHV8 positive versus 4.9% seronegative. The odds ratio calculation shows a strong correlation with a p value of 0.01. No correlation was found between HHV8 infection of the mother and neonate mortality or Apgar score. However, a relationship did show up between HHV8 infection of the mother and low birth weight. 29.2% of seropositive women had had a child with a birth weight under 2600 g whereas only 16.3% of seronegative women had had babies with low birth weight. We determined that HHV8 is indeed present in Senegal. Further studies should focus on transmission routes as well as the molecular epidemiology of this virus and diseases related to HHV8 infection in Senegal.
authors.affiliation: Laboratoire de bactériologie-virologie, CHU A Le Dantec, BP 7325, Dakar, Sénégal.
authors.forename: A
authors.initials: A
authors.lastname: Gaye-Diallo
authors.forename: A T
authors.initials: AT
authors.lastname: Touré
authors.forename: A
authors.initials: A
authors.lastname: Gessain
authors.forename: A
authors.initials: A
authors.lastname: Guèye-Ndiaye
authors.forename: A N
authors.initials: AN
authors.lastname: Ndour
authors.forename: N C
authors.initials: NC
authors.lastname: Touré-Kane
authors.forename: M C
authors.initials: MC
authors.lastname: Dia
authors.forename: G
authors.initials: G
authors.lastname: de Thé
authors.forename: S
authors.initials: S
authors.lastname: Mboup
mesh_terms: D000022:Abortion, Spontaneous / Q000821:virology; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005865:Gestational Age; D006679:HIV Seropositivity; D006566:Herpesviridae Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000635:transmission; D019288:Herpesvirus 8, Human / Q000276:immunology; D006801:Humans; D007226:Infant Mortality; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D012675:Senegal / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral