title: Purpura due to aspirin-induced platelet dysfunction aggravated by drinking alcohol.
abstract: We report a rare case of prominent purpura induced by aspirin and enhanced by alcohol. A 44-year-old woman presented with a history of generalized purpura. She drank alcohol once or twice a week and regularly took an analgesic preparation, containing aspirin and acetaminophen, for alleviation of headaches. When purpura was evident the patient's liver function was within normal limits and her coagulation time was normal but her bleeding time was prolonged. Red blood cell, white blood cell and platelet counts were normal but a poor response to platelet agonists demonstrated platelet dysfunction. After stopping the analgesic and abstaining from alcohol for 5 days, platelet aggregation, in response to the agonists, returned to normal and purpura disappeared. When the patient took further doses of the analgesic preparation for 3 days for headache relief, but did not drink alcohol, platelet aggregation was again abnormal but purpura was only slight.
authors.affiliation: Department of Blood Transfusion Medicine and Clinical Haematology, Wakayama Medical University, Wakayama City, Japan. ta-tsuda@wakayama-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Tsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
authors.forename: R
authors.initials: R
authors.lastname: Sakaguchi
authors.forename: N
authors.initials: N
authors.lastname: Katayama
authors.forename: I
authors.initials: I
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Ota
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001791:Blood Platelet Disorders / Q000097:blood / Q000139:chemically induced*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D011693:Purpura / Q000097:blood / Q000139:chemically induced*
chemical_list: D001241:Aspirin