title: Arterial blood gas management in retrograde cerebral perfusion: the importance of carbon dioxide.
abstract: OBJECTIVE
  Many interventional physiological assessments for retrograde cerebral perfusion (RCP) have been explored. However, the appropriate arterial gas management of carbon dioxide (CO2) remains controversial. The aim of this study is to determine whether alpha-stat or pH-stat could be used for effective brain protection under RCP in terms of cortical cerebral blood flow (CBF), cerebral metabolic rate for oxygen (CMRO2), and distribution of regional cerebral blood flow.
  
  
  METHODS
  Fifteen anesthetized dogs (25.1+/-1.1 kg) on cardiopulmonary bypass (CPB) were cooled to 18 degrees C under alpha-stat management and had RCP for 90 min under: (1), alpha-stat; (2), pH-stat; or (3), deep hypothermic (18 degrees C) antegrade CPB (antegrade). RCP flow was regulated for a sagittal sinus pressure of around 25 mmHg. CBF was monitored by a laser tissue flowmeter. Serial analyses of blood gas were made. The regional cerebral blood flow was measured with colored microspheres before discontinuation of RCP. CBF and CMRO2 were evaluated as the percentage of the baseline level (%CBF, %CMRO2).
  
  
  RESULTS
  The oxygen content of arterial inflow and oxygen extraction was not significantly different between the RCP groups. The %CBF and %CMRO2 were significantly higher for pH-stat RCP than for alpha-stat RCP. The regional cerebral blood flow, measured with colored microspheres, tended to be higher for pH-stat RCP than for alpha-stat RCP, at every site in the brain. Irrespective of CO2 management, regional differences were not significant among any site in the brain.
  
  
  CONCLUSIONS
  CO2 management is crucial for brain protection under deep hypothermic RCP. This study revealed that pH-stat was considered to be better than alpha-stat in terms of CBF and oxygen metabolism in the brain. The regional blood flow distribution was considered to be unchanged irrespective of CO2 management.
authors.affiliation: Department of Cardiothoracic Surgery, University of Tokyo, Tokyo, Japan. kueno-tky@umin.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Ueno
authors.forename: S
authors.initials: S
authors.lastname: Takamoto
authors.forename: T
authors.initials: T
authors.lastname: Miyairi
authors.forename: T
authors.initials: T
authors.lastname: Morota
authors.forename: K
authors.initials: K
authors.lastname: Shibata
authors.forename: A
authors.initials: A
authors.lastname: Murakami
authors.forename: Y
authors.initials: Y
authors.lastname: Kotsuka
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001921:Brain / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood*; D002315:Cardiopulmonary Bypass; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004285:Dogs; D010100:Oxygen / Q000097:blood; D012039:Regional Blood Flow
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen