title: [Recent advance in inhaled corticosteroid therapy].
abstract: Inhaled corticosteroid therapy against bronchial asthma has developed rapidly and remarkably during last 10 years. The significance of this therapy has been established in a lot of international guidelines for asthma management. Early intervention, which developed from the concept of step-down therapy, is new therapeutic approach to prevent the remodeling of airway walls deemed as the major cause of irreversible airflow limitation which makes patient chronic and refractory asthmatics. It is comprehensive therapeutic approach which include not only early diagnosis, early intensive corticosteroid therapy, but also environment intervention and enough patient education. In addition to this new therapeutic strategy, we will describe about add-on effect of long-acting beta-2 agonists, theophylline, and leukotriene receptor antagonist.
authors.affiliation: Department of Respiratory Medicine, International Medical Center of Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hojo
authors.forename: K
authors.initials: K
authors.lastname: Kudo
mesh_terms: D000280:Administration, Inhalation; D000287:Administration, Topical; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000730:Androstadienes / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage; D001993:Bronchodilator Agents / Q000008:administration & dosage; D019819:Budesonide / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D000068298:Fluticasone; D005938:Glucocorticoids; D006801:Humans; D020024:Leukotriene Antagonists / Q000008:administration & dosage; D017410:Practice Guidelines as Topic; D013806:Theophylline / Q000008:administration & dosage
chemical_list: D000318:Adrenergic beta-Agonists; D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D005938:Glucocorticoids; D020024:Leukotriene Antagonists; D019819:Budesonide; D013806:Theophylline; D000068298:Fluticasone; D001507:Beclomethasone