The enantioselective binding of mefloquine enantiomers to P-glycoprotein determined using an immobilized P-glycoprotein liquid chromatographic stationary phase.
Lu
L
L
Department of Pharmacology, School of Medicine, Georgetown University, Washington, DC 20007, USA.
Leonessa
F
F
Baynham
M T
MT
Clarke
R
R
Gimenez
F
F
Pham
Y T
YT
Roux
F
F
Wainer
I W
IW
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000962:Antimalarials / Q000737:chemistry / Q000493:pharmacokinetics*; D001665:Binding Sites; D001667:Binding, Competitive / Q000187:drug effects; D002845:Chromatography; D002846:Chromatography, Affinity; D016572:Cyclosporine / Q000378:metabolism; D006801:Humans; D008024:Ligands; D015767:Mefloquine / Q000737:chemistry / Q000493:pharmacokinetics*; D011485:Protein Binding; D013237:Stereoisomerism; D014747:Vinblastine / Q000378:metabolism
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000962:Antimalarials; D008024:Ligands; D014747:Vinblastine; D016572:Cyclosporine; D015767:Mefloquine