Noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone derivatives. part I: synthesis and SAR studies for the inhibition of TNF-alpha production.
This study describes the synthesis and in vitro evaluation of noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone derivatives for the inhibition of TNF-alpha production. Among these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyll-3-methyl-1-isoindolinone (5) was the most potent in inhibitory activity of TNF-alpha production in LPS-stimulated RAW264.7 cells.
Park
J S
JS
Institute of Biosciences & Biotechnology, Daewoong Pharm Co. Ltd., Yongin, Kyunggi-do 449-814, Korea. joonchem@daewoong.co.kr
Baik
K U
KU
Cho
J Y
JY
Yoo
E S
ES
Byun
Y S
YS
Park
M H
MH
D000818:Animals; D002460:Cell Line; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D007202:Indicators and Reagents; D007211:Indoles; D014409:Tumor Necrosis Factor-alpha