B-cell acute lymphoblastic leukemia with tandem t(14;14)(q11;q32).
Translocation (14;14)(q11;q32) was associated with acute lymphoblastic leukemia in a child. The B-cell lineage of the leukemic cells led us to perform FISH studies, which showed that the chromosomal breakpoints were telomeric to TCRA/D and IGH loci. These findings show that FISH analyses are necessary when unusual features are associated with a recurrent translocation.
Berger
R
R
INSERM U 434, SDI 401 No.434 CNRS, Institut de Génétique Moléculaire, 27 rue Juliette Dodu, 75010, Paris, France. roland.berger@cephb.fr
Busson
M
M
Daniel
M T
MT
D002051:Burkitt Lymphoma / Q000235:genetics*; D002648:Child; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains; D011948:Receptors, Antigen, T-Cell