The integration of high throughput technologies for drug discovery.
Producing quality clinical candidates less prone to late stage failure is greatly facilitated by better integration of the relevant high throughput functions and the inclusion of ADME/toxicology further upstream in the discovery process. We describe the tasks and their integration in the context of the design, make and test triad.
Sabbatini
G P
GP
Discovery Partners International, San Diego, CA 92121, USA. greg.sabbatini@discovery-tech.com
Shirley
W A
WA
Coffen
D L
DL
D001331:Automation; D020650:Combinatorial Chemistry Techniques; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D008958:Models, Molecular
D003577:Cytochrome P-450 Enzyme System