title: Long-term treatment of recurrent and chronic depression.
abstract: Depression is associated with high rates of impairment and comorbidity with other disorders and has a devastating effect on those who suffer from it. Treatment options are available and can greatly improve functioning; however, undertreatment still persists. Undertreatment may result from incorrect or incomplete diagnoses or inadequate treatment duration. In addition, when treating depression, clinicians must identify underlying conditions, life-span issues, and proper treatment duration to maximize outcome. This article provides an overview of the underlying implications of depression. reviews issues in treating chronic depression that are still unresolved, and recommends standards for maintenance therapy.
authors.affiliation: Department of Psychiatry and Human Behavior, Brown University-Butler Hospital, Providence, RI 02906, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Keller
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D002908:Chronic Disease; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D017281:Cost of Illness; D003866:Depressive Disorder / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy*; D004185:Disability Evaluation; D004334:Drug Administration Schedule; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D010879:Piperazines; D010919:Placebos; D012008:Recurrence; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D010879:Piperazines; D010919:Placebos; D014230:Triazoles; D005473:Fluoxetine; C051752:nefazodone