Kinesin, dynein and neurofilament transport.
The recent demonstration that the fast axonal transport motors kinesin and dynein participate in axonal transport of neurofilaments--known to undergo slow transport--supports and extends recent studies indicating that some neurofilaments exhibit alternating bursts of fast axonal transport interspersed with periods of non-motility. In addition, these findings unify both certain aspects of axonal transport and neurofilament biology. We discuss these data herein in the context of both older and more recent studies of neurofilament dynamics.
Shea
T B
TB
Center for Cellular Neurobiology and Neurodegeneration Research, Dept of Biological Sciences, University of Massachusetts Lowell, 01854, USA.Thomas_Shea@uml.edu
Flanagan
L A
LA
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D004398:Dyneins / Q000502:physiology*; D016547:Kinesins / Q000502:physiology*; D016900:Neurofilament Proteins / Q000378:metabolism*; D010766:Phosphorylation
D016900:Neurofilament Proteins; D004398:Dyneins; D016547:Kinesins