Regulation of NO-producing function of the lungs with salmeterol.
The state of epithelial nitric oxide synthase, bronchomotor reaction, and concentration of NO metabolites (NO(2)(-) and NO(3)(-)) in bronchoalveolar lavage fluid were studied in healthy rats and rats with experimental bronchial asthma induced by inhalations of long-acting beta(2)-agonist salmeterol. The effects of salmeterol on NO-producing function of the lung in healthy animals and in animals with bronchial asthma were studied.
Eliseeva
E V
EV
Department of Histology, Vladivostok State Medical University. aelisee@rbcmail.ru
Romanova
N A
NA
Maistrovskaya
Y V
YV
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000420:Albuterol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D001993:Bronchodilator Agents / Q000494:pharmacology; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III; D051381:Rats; D020545:Respiratory Mucosa / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D000068299:Salmeterol Xinafoate
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D009569:Nitric Oxide; D000068299:Salmeterol Xinafoate; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D000420:Albuterol