Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats.
In the present study, the anti-inflammatory activity of 70% ethanolic extract of Pongamia pinnata leaves (PLE) in acute, subacute and chronic models of inflammation was assessed in rats. Per os (p.o.) administration of PLE (300, 1000 mg/kg) exhibited significant anti-inflammatory activity in acute (carrageenin, histamine, 5-hydroxytryptamine and prostaglandin E2-induced hind paw edema), subacute (kaolin-carrageenin and formaldehyde-induced hind paw edema) and chronic (cotton pellet granuloma) models of inflammation. PLE did not show any sign of toxicity and mortality up to a dose level of 10.125 g/kg, p.o. in mice. Both acute as well as chronic administration of PLE (100, 300 and 1000 mg/kg, p.o.) did not produce any gastric lesion in rats. These results indicate that PLE possesses significant anti-inflammatory activity without ulcerogenic activity suggesting its potential as an anti-inflammatory agent for use in the treatment of various inflammatory diseases.
Srinivasan
K
K
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar 243 122, U.P., India.
Muruganandan
S
S
Lal
J
J
Chandra
S
S
Tandan
S K
SK
Prakash
V R
VR
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000139:chemically induced*; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts