Total Synthesis of cis- and trans-3-Hydroxy-D-proline and (+)-Detoxinine.
The unnatural enantiomer of the amino acid detoxinine and both diastereomeric 3-hydroxy-D-prolines have been prepared from D-mannitol via the O-silylated hydroxyproline 12 as a common key intermediate.
Mulzer
Johann
J
Institut für Kristallographie der Freien Universität Berlin, Takustrasse 6, D-14195 Berlin, Germany.
Meier
Andreas
A
Buschmann
Jürgen
J
Luger
Peter
P