title: [Problems of radiation therapy of patients with malignant tumors and modern ways of resolving them].
abstract: At the present stage of radiation oncology, treatment successes are mainly determined by improvement of multimodality therapy that utilizes benefits of each modality in individual patients. Radiotherapy is mostly empiric, as demonstrated by dose fractionation. Its significance in many situations is underestimated, which leads to unreasonably excessive irradiation or, vice versa, to its unreasonable refusal. So clinical searches for new knowledge of the actual role of radiotherapy in specific clinical situations are therefore continued. The advent of new-generation radiation therapy apparatuses opens up fresh opportunities for development of rational radiation methods by mathematically optimizing dosage fields of irradiation and creating its conformable conditions. The necessary conditions for further radiotherapy successes are continuation of research developments in rational simulation of spatial dosage distribution, in the use of radio sensibilizers and radio protectors, and in contact methods of radiotherapy and intraoperative irradiation.
authors.forename: G V
authors.initials: GV
authors.lastname: Goldobenko
authors.forename: S I
authors.initials: SI
authors.lastname: Tkachev
authors.forename: M I
authors.initials: MI
authors.lastname: Nechushkin
authors.forename: T V
authors.initials: TV
authors.lastname: Iur'eva
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D011829:Radiation Dosage; D011878:Radiotherapy / Q000009:adverse effects