[Inhaled corticosteroid therapy in childhood asthma].
Asthma has been recognized as a chronic inflammatory disorder of the airway. The early use of antiinflammatory agents, one of which is inhaled corticosteroids, is advocated in the treatment of chronic asthma. Beclomethasone dipropionate (BDP) is effective in childhood asthma. CD4 T-cell activation correlate with the values of the coefficient variation (CV) of peak expiratory flow (PEF) in asthmatic patients, suggesting that CV of PEF is a good marker for assessing not only the variability of airway obstruction but also the degree of airway inflammation. PEF monitoring is useful for better controlling asthma, because some patients treated with inhaled corticosteroid may still remain undertreated.
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Department of Pediatric Allergy, Osaka Prefectural Habikino Hospital.
D000280:Administration, Inhalation; D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D001507:Beclomethasone / Q000008:administration & dosage*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D002908:Chronic Disease; D004205:Cromolyn Sodium / Q000008:administration & dosage; D006801:Humans; D008213:Lymphocyte Activation; D008991:Monitoring, Physiologic; D010366:Peak Expiratory Flow Rate
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001507:Beclomethasone; D004205:Cromolyn Sodium