Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl.
The modifying effects of three kinds of fat (corn oil, beef tallow or perilla oil, each at 20% in the diet) on F344 rat prostate carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl (DMAB) were investigated. Non-invasive carcinomas of the ventral prostate were induced by DMAB alone and invasive carcinomas of the other prostate lobes and seminal vesicles by DMAB and testosterone propionate (TP). Eight groups of F344 rats were initiated with 50 mg / kg body weight of DMAB at 2-week intervals for the first 20 weeks, four also receiving TP, extended until week 60. The animals received basal chow powder diet or one of three high fat diets throughout the experiment (60 weeks). One further group served as a non-carcinogen-treated control maintained on basal chow powder diet. Beef tallow significantly increased the development of ventral prostate carcinomas with DMAB alone (from 15 to 45%, P < 0.05), while perilla oil reduced the incidence of prostatic intraepithelial neoplasia (PIN) in the ventral lobe of rats given DMA + TP (from 70 to 10%, P < 0.01), but not in those given DMAB alone. No other effects of high fats were observed regarding PIN or invasive cancers of the dorsolateral and anterior prostate or seminal vesicles. A satellite experiment demonstrated that all high fat diets for 4 weeks increased the 5-bromo-2-deoxyuridine (BrdU) labeling index of prostate epithelial cells, suggesting that a high fat intake, irrespective of the fatty acid composition, may accelerate cell kinetics in the prostate. Of the three high fat diets, beef tallow was also found to increase intestinal carcinogenesis. Thus, the present data revealed carcinogenesis in the prostate and intestine to be promoted by beef tallow.
Mori
T
T
First Department of Pathology, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601.
Imaida
K
K
Tamano
S
S
Sano
M
M
Takahashi
S
S
Asamoto
M
M
Takeshita
M
M
Ueda
H
H
Shirai
T
T
D000611:Aminobiphenyl Compounds / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000009:adverse effects / Q000494:pharmacology; D002417:Cattle; D003314:Corn Oil / Q000009:adverse effects / Q000494:pharmacology*; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology*; D005223:Fats / Q000009:adverse effects / Q000494:pharmacology*; D015994:Incidence; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D008297:Male; D008460:Meat; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils; D011467:Prostate / Q000187:drug effects / Q000473:pathology; D011471:Prostatic Neoplasms / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D012669:Seminal Vesicles / Q000187:drug effects / Q000473:pathology; D017962:alpha-Linolenic Acid / Q000009:adverse effects / Q000494:pharmacology*
D000611:Aminobiphenyl Compounds; D002273:Carcinogens; D004041:Dietary Fats; D005223:Fats; D010938:Plant Oils; D017962:alpha-Linolenic Acid; C001042:2',3-dimethyl-4-aminobiphenyl; C058216:perilla seed oil; D003314:Corn Oil; C013698:tallow