Syntheses of analogues of the insect neuropeptide proctolin containing an oxazole ring as an amide bond replacement.
[structure: see text]. Three oxazole analogues of the insect neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) have been prepared, containing a single oxazole between Tyr and Pro and between Pro and Thr, respectively. A compound containing an oxazole moiety between Tyr and Pro and between Pro and Thr has also been prepared. All compounds have been tested for myotropic activity.
Plant
A
A
Bayer AG, Central Research, 51368 Leverkusen, Germany.
Stieber
F
F
Scherkenbeck
J
J
Lösel
P
P
Dyker
H
H
D000577:Amides / Q000737:chemistry; D000818:Animals; D004064:Digestive System / Q000187:drug effects; D006110:Grasshoppers / Q000737:chemistry* / Q000502:physiology; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009119:Muscle Contraction / Q000187:drug effects; D009479:Neuropeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010080:Oxazoles / Q000138:chemical synthesis*; D010084:Oxidation-Reduction
D000577:Amides; D007202:Indicators and Reagents; D009479:Neuropeptides; D009842:Oligopeptides; D010080:Oxazoles; C011536:proctolin