P2X7 receptors and apoptosis in tuberculosis infection.
Immune cells express P2 purinoceptors of the P2Y and P2X subtypes. Evidence accumulated has shown that many different cell types are killed by sustained exposure to high concentrations of extracellular ATP. Depending on the ATP dose, length of stimulation and receptor subtype, P2X receptor stimulation may cause necrosis or apoptosis. Triggering of apoptosis, in response to intracellular infection, has been identified for a wide range of pathogens and host organisms, and there is now emerging interest about mechanism mediating host cell death and its role in pulmonary tuberculosis. The physiological meaning of P2X receptor-dependent cell death is not completely understood, but and involvement in immune-mediated reactions is postulated.
Mancino
G
G
Research Center San Pietro Hospital, Fatebenefratelli, Rome, Italy. mancino@uniroma2.it
Placido
R
R
Di Virgilio
F
F
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D006801:Humans; D010587:Phagocytosis; D018048:Receptors, Purinergic P2 / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D058486:Receptors, Purinergic P2X7; D014376:Tuberculosis / Q000276:immunology / Q000473:pathology*
C546468:P2RX7 protein, human; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7; D000255:Adenosine Triphosphate