Quantitative determination of famotidine through charge-transfer complexation with chloranilic acid.
Quantitative determination of famotidine and its dosage forms was carried out spectrophotometrically, analysing the coloured complex resulting from a charge-transfer interaction between the drug as an electron-donor and chloranilic acid as an electron-acceptor. Famotidine-Chloranilic acid complex displayed l-max at 5 25 nm. Conditions and time for complex formation have been optimized. The stoichiometry of the complex is 3:2 donor to acceptor mole ratio. Calibration graph of the complex was found to be linear at a working concentration range of 1.60-11.g% (w/v). Excellent quantitative recoveries (99.01-100.71%) was obtained for the drugs in both its pure and standard dosage forms.
Chukwurah
B K
BK
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Ajali
U
U
D016227:Benzoquinones / Q000737:chemistry*; D002138:Calibration; D004563:Electrochemistry; D004583:Electrons; D015738:Famotidine / Q000032:analysis*; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D016227:Benzoquinones; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D013607:Tablets; D015738:Famotidine; C014400:chloranilic acid