Determination of zinc in pharmaceutical products by use of a sequential injection analysis system.
A sequential injection analysis (SIA) system is proposed for the determination of zinc in pharmaceutical samples. The method is based on the spectrophotometric detection of zinc using xylenol orange as a colour reagent at 568 nm. The system can be used to monitor zinc at a frequency of 30 samples h(-1) with an average recovery of +/-98.5% and a relative standard deviation of less than 1%. A linear relationship between peak height and zinc concentration is obtained between 10 and 60 mg L(-1). The results obtained are in good agreement with those obtained by use of a standard method.
van Staden
J K
JK
Department of Chemistry, University of Pretoria, South Africa. koos.vanStaden@chem.up.ac.za
Tsanwani
M
M
D017022:Flow Injection Analysis / Q000379:methods; D004364:Pharmaceutical Preparations / Q000032:analysis*; D010636:Phenols; D013053:Spectrophotometry / Q000379:methods; D013454:Sulfoxides; D014992:Xylenes / Q000737:chemistry; D015032:Zinc / Q000032:analysis*
D004364:Pharmaceutical Preparations; D010636:Phenols; D013454:Sulfoxides; D014992:Xylenes; D015032:Zinc; C016833:xylenol orange