title: [Rhinocerebral mucormycosis: apropos of 4 new Tunisian cases].
abstract: Mucormycosis is a rare opportunistic infection but a fulminant disease. We report the 4 first cases of rhinocerebral mucormycosis diagnosed in Sfax region (Tunisia). They occurred in insulin dependent diabetes and developed varying clinical manifestations from facial cellulites to ocular and cerebral extension. The diagnosis of mucormycosis was not initially evoked, but confirmed tardively by anatomopathologic and mycologic examinations. The evolution was favourable in 2 cases by administration of amphotericine B associated with extensive surgical debridement and correction of the diabetes. Two patients had a fatal outcome. This infection has a severe prognosis and necessitates early diagnosis.
authors.affiliation: Laboratoire de parasitologie-mycologie, CHU H. Bourguiba, Sfax, Tunisie.
authors.forename: F
authors.initials: F
authors.lastname: Makni
authors.forename: F
authors.initials: F
authors.lastname: Cheikh-Rouhou
authors.forename: A
authors.initials: A
authors.lastname: Ayadi
authors.forename: M
authors.initials: M
authors.lastname: Abdelmoula
authors.forename: F
authors.initials: F
authors.lastname: Karray
authors.forename: I
authors.initials: I
authors.lastname: Maaloul
authors.forename: B
authors.initials: B
authors.lastname: Khemakhem
mesh_terms: D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000382:microbiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000628:therapy; D005128:Eye Diseases / Q000382:microbiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D009668:Nose Diseases / Q000382:microbiology*; D011379:Prognosis; D014416:Tunisia
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B