Hibiscus acid as an inhibitor of starch digestion in the Caco-2 cell model system.
Hibiscus acid, an alpha-amylase inhibitor isolated from roselle tea, and its derivatives were compared in an inhibition test for starch digestion. An alpha-amylase-added Caco-2 system was established as a useful model to evaluate the effects of alpha-glucosidase inhibitors on starch digestion. Hibiscus acid showed weak inhibition in this model system, and the methyl ester derivatives showed even weaker or no acitivity.
Hansawasdi
C
C
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Kawabata
J
J
Kasai
T
T
D000818:Animals; D018938:Caco-2 Cells; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid / Q000494:pharmacology; D004063:Digestion / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D020128:Inhibitory Concentration 50; D010179:Pancreas / Q000201:enzymology; D013213:Starch / Q000378:metabolism*; D013552:Swine; D000516:alpha-Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism
D002951:Citrates; D065089:Glycoside Hydrolase Inhibitors; D019343:Citric Acid; C007999:hydroxycitric acid; D013213:Starch; D000516:alpha-Amylases; D000520:alpha-Glucosidases; D005947:Glucose