title: Re-occurrence of HIV-1 drug mutations after treatment re-initiation following interruption in patients with multiple treatment failure.
abstract: Antiretroviral treatment interruption in 20 extensively pre-treated HIV-1 patients with treatment failure led to genotype viral reversion of at least one class of drug-mutation resistance in half of the patients. The only predictive factor of reversion was found to be the duration of interruption. The outgrowth of residual wild-type virus seems not to be a true genetic reversion because drug mutations are detected rapidly at salvage therapy re-initiation.
authors.affiliation: Department of Virology, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Delaugerre
authors.forename: M A
authors.initials: MA
authors.lastname: Valantin
authors.forename: M
authors.initials: M
authors.lastname: Mouroux
authors.forename: M
authors.initials: M
authors.lastname: Bonmarchand
authors.forename: G
authors.initials: G
authors.lastname: Carcelain
authors.forename: C
authors.initials: C
authors.lastname: Duvivier
authors.forename: R
authors.initials: R
authors.lastname: Tubiana
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: F
authors.initials: F
authors.lastname: Bricaire
authors.forename: H
authors.initials: H
authors.lastname: Agut
authors.forename: B
authors.initials: B
authors.lastname: Autran
authors.forename: C
authors.initials: C
authors.lastname: Katlama
authors.forename: V
authors.initials: V
authors.lastname: Calvez
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D004334:Drug Administration Schedule; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D009154:Mutation; D012367:RNA, Viral / Q000097:blood; D017211:Treatment Failure
chemical_list: D012367:RNA, Viral