Rearrangement of a 16alpha,17alpha-Epoxy-16beta-methylandrostane-17beta-carbothioic Acid to a 17beta-Mercapto-16beta-methylandrostane-17alpha,16alpha-carbolactone.
The 16alpha,17alpha-epoxy-16beta-methylandrostane-17beta-carbothioic acid 2b rearranges in solution at ambient temperature to the 17beta-mercapto-16beta-methylandrostane-17alpha,16alpha-carbolactone 6a, possibly via the spirocyclic alpha-thiolactone 5.
Bain
Brian M.
BM
Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
Phillipps
Gordon H.
GH
Procopiou
Panayiotis A.
PA
Steeples
Ian P.
IP
Upton
Richard J.
RJ