Genetic control of disease resistance and immunoresponsiveness.
A great deal of evidence points to substantial genetic control over at least some of the immune responses, although genetic parameters for clinical disease have been less favorable. The past two decades have illustrated that single genes with a large impact on food animal health do exist and can be used to improve the health of domestic populations. The current focus on molecular genetics within food animal species will likely unveil numerous other examples of single genes with large effects, although the use of animals possessing favorable genotypes for disease resistance may represent a compromise in selection for increased production of raw product. Moreover, it is also clear that genetic control over the immune system is not limited to a few genes but is more likely influenced by many genes, each with small effects. The use of this information in animal improvement programs is not straightforward because of factors complicating the identification of superior individuals within the population. The scarcity of information dealing with phenotypic and genetic relationships between measures of disease resistance and aspects of immune response complicates the situation even further. Despite these potential hurdles, the potential for permanent improvement of disease resistance within food animal species in the future is tantalizing and merits intensified future study.
Kelm
S C
SC
Department of Animal and Food Science, University of Wisconsin-River Falls, River Falls, Wisconsin, USA. steven.kelm@uwrf.edu
Freeman
A E
AE
Kehrli
M E
ME
D000827:Animal Welfare; D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics / Q000276:immunology*; D002418:Cattle Diseases / Q000235:genetics* / Q000276:immunology / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D005838:Genotype; D007113:Immunity, Innate; D010641:Phenotype; D012641:Selection, Genetic