title: Chromatin elimination--an oddity or a common mechanism in differentiation and development?
abstract: Over many decades, a great number of exceptions from the rule of equal segregation of the chromosomes during cell division have been found in different animal species. The most diversified is the process of chromosome re-arrangement that takes place during the specification of soma versus germ-line cell fate in the embryos from the whole spectrum of animal phyla. In nematodes, copepodes, insects, hagfish, and marsupials, the chromatin/chromosome elimination is a common path of normal cell differentiation and development. This also raises the question of the mechanisms and factors that promote elimination in pre-somatic cell lines and/or inhibit the elimination in the prospective germ cells. We will discuss the possible role of the germ plasm in this process.
authors.affiliation: Department of Molecular Genetics, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA. mkloc@notes.mdacc.tmc.edu
authors.forename: M
authors.initials: M
authors.lastname: Kloc
authors.forename: B
authors.initials: B
authors.lastname: Zagrodzinska
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D002843:Chromatin / Q000502:physiology*; D016798:Ciliophora / Q000235:genetics; D005260:Female; D005399:Fishes / Q000235:genetics; D005854:Germ Cells / Q000502:physiology*; D007313:Insecta / Q000235:genetics; D008297:Male; D008394:Marsupialia / Q000235:genetics; D008957:Models, Genetic; D009348:Nematoda / Q000235:genetics; D012730:Sex Chromosomes
chemical_list: D002843:Chromatin