title: The reaction of digitoxin and digoxin with cyanoacetic acid hydrazide: synthesis of coumarin, thiazole, thiophene and pyridine derivatives with potential biological activities.
abstract: The reaction of either Digitoxin or Digoxin with cyanoacetic acid hydrazide gave the hydrazone derivatives 3a and 3b respectively. The reactivity of the latter products towards chemical reagents was studied to give heterocyclic derivatives with potential biological activities.
authors.affiliation: Hormones Department, National Research Center, Dokki, Giza, Egypt. rmmohareb@hotmail.com
authors.forename: S H
authors.initials: SH
authors.lastname: Doss
authors.forename: W W
authors.initials: WW
authors.lastname: Wardakhan
authors.forename: N A
authors.initials: NA
authors.lastname: Louca
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis; D004074:Digitoxin / Q000737:chemistry*; D004077:Digoxin / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis; D013844:Thiazoles / Q000138:chemical synthesis; D013876:Thiophenes / Q000138:chemical synthesis
chemical_list: D003374:Coumarins; D006834:Hydrazines; D007202:Indicators and Reagents; D011725:Pyridines; D013844:Thiazoles; D013876:Thiophenes; C004703:cyacetacide; D004077:Digoxin; D004074:Digitoxin