Synthesis of Functionalized Deuterioallylic Compounds.
Functionalized deuterioallylic compounds were efficiently prepared by reaction of the corresponding propargylic derivative with the Schwartz reagent followed by hydrolysis of the adduct with D(2)O. The Z-3-deuterio-2-propenylstannane, prepared in pure form for the first time, is a useful reagent for the preparation of deuterioallylic compounds which cannot be synthesized by hydrozirconation of the corresponding derivatives.
Orain
David
D
Laboratoire de Synthèses et Activations de Biomolécules, ESA 6052, ENSCR, Avenue du Général Leclerc, 35700 Rennes, France.
Guillemin
Jean-Claude
JC