A computer model of human atria with reasonable computation load and realistic anatomical properties.
Atrial fibrillation is the most frequent arrhythmia, provoking discomfort, heart failure and arterial embolisms. The aim of this work is to develop a simplified anatomical computer model of human atria for the study of atrial arrhythmias and the understanding of electrical propagation mechanisms. With the model we propose, up to 40 s of real-time propagation have been simulated on a single-processor computer. The size and the electrophysiological properties of the simulated atria are within realistic values and information about anatomy has been taken into account in a three-dimensional structure. Besides normal sinus beat, pathological phenomena such as flutter and fibrillation have been induced using a programmed stimulation protocol. One important observation in our model is that atrial arrhythmias are a combination of functional and anatomical reentries and that the geometry plays an important role. This virtual atrium can reproduce electrophysiological observations made in humans but with the advantage of showing in great detail how arrhythmias are initiated and sustained. Such details are difficult or impossible to study in humans. This model will serve us as a tool to evaluate the impact of new therapeutic strategies and to improve them.
Blanc
O
O
Signal Processing Laboratory, Swiss Federal Institute of Technology, Lausanne.
Virag
N
N
Vesin
J M
JM
Kappenberger
L
L
D001281:Atrial Fibrillation / Q000503:physiopathology; D016275:Atrial Function; D001698:Biomedical Engineering; D003198:Computer Simulation; D004594:Electrophysiology; D006321:Heart / Q000033:anatomy & histology* / Q000502:physiology*; D006325:Heart Atria / Q000033:anatomy & histology; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D014584:User-Computer Interface