title: The effectiveness of enamel matrix proteins used in combination with bovine porous bone mineral in the treatment of intrabony defects in humans.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effectiveness of enamel matrix proteins (EMPs) used in combination with bovine porous bone mineral (BPBM), compared to open flap debridement (OFD) in the treatment of intrabony defects in humans.
  
  
  METHODS
  Using a split-mouth design, 24 paired intrabony defects were surgically treated and re-entered 6 months later. Experimental sites were treated with EMPs and grafted with BPBM. Control sites were treated with an OFD. The primary outcomes evaluated in the study were changes in pocket depth, clinical attachment level and defect bone fill.
  
  
  RESULTS
  Preoperative pocket depths, attachment levels and intra-operative bone measurements were similar for control and experimental sites. 6-month post surgical measurements revealed a significantly greater reduction in pocket depth (differences of 2.35+/-0.86 mm on buccal and 2.28+/-0.90 mm on lingual measurements) and more gain in clinical attachment (differences of 2.04+/-0.28 mm on buccal and 1.99+/-0.26 mm on lingual measurements) in the experimental sites. Surgical reentry of the defects revealed a significantly greater amount of defect fill in favor of the experimental sites (differences of 2.85+/-0.28 mm on buccal and 2.67+/-0.33 mm on lingual measurements).
  
  
  CONCLUSIONS
  The results of this study suggest that combining EMPs and BPBM as a regenerative technique for intraosseous defects results in statistically and clinically significant more favorable results than OFD. The nature of the attachment between the newly regenerated tissue and the root surfaces needs to be evaluated histologically to confirm the presence of new attachment.
authors.affiliation: University of California, Los Angeles, School of Dentistry, CA 90095, USA. pauloc@dentnet.ucla.edu
authors.forename: P M
authors.initials: PM
authors.lastname: Camargo
authors.forename: V
authors.initials: V
authors.lastname: Lekovic
authors.forename: M
authors.initials: M
authors.lastname: Weinlaender
authors.forename: N
authors.initials: N
authors.lastname: Vasilic
authors.forename: E B
authors.initials: EB
authors.lastname: Kenney
authors.forename: M
authors.initials: M
authors.lastname: Madzarevic
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003646:Debridement; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D012534:Dental Scaling; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008903:Minerals / Q000627:therapeutic use; D015588:Observer Variation; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D016745:Root Planing; D013223:Statistics as Topic; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D003746:Dental Enamel Proteins; D008903:Minerals; C109069:enamel matrix proteins