title: Therapy-related myelodysplastic syndrome (t-MDS) in a patient with anaplastic astrocytoma: successful treatment with allogeneic bone marrow transplant.
abstract: OBJECTIVE
  and importance Therapy-related myelodysplastic syndrome (t-MDS) is a rare and typically fatal complication of therapy for cancer, including brain tumors. We report successful therapy of t-MDS that developed after treatment for an anaplastic astrocytoma.
  
  
  METHODS
  t-MDS developed four and one-half years after successful therapy (resection, radiation and chemotherapy) administered for a cerebral anaplastic astrocytoma in a 34-year-old patient.
  
  
  METHODS
  The patient was treated with allogeneic bone marrow transplant (BMT) for t-MDS.
  
  
  CONCLUSIONS
  She is alive three years after BMT with no evidence of brain tumor and in complete remission from t-MDS. To our knowledge, this is the first report of allogeneic BMT administered for t-MDS in an adult brain tumor patient. Clinicians must be alert to the development of t-MDS following chemotherapy for brain tumors and initiate appropriate treatment promptly.
authors.affiliation: Department of Neurosurgery, The Hermelin Brain Tumor Center and Henry Ford Hospital, Detroit, MI 48202, USA. lrogers@neuro.hfh.edu
authors.forename: L R
authors.initials: LR
authors.lastname: Rogers
authors.forename: N
authors.initials: N
authors.lastname: Janakiraman
authors.forename: C
authors.initials: C
authors.lastname: Kasten-Sportes
authors.forename: M L
authors.initials: ML
authors.lastname: Rosenblum
mesh_terms: D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000139:chemically induced / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001254:Astrocytoma / Q000628:therapy*; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D014184:Transplantation, Homologous