Comparison of ready-to-use EMDOGAIN-gel and EMDOGAIN in patients with chronic adult periodontitis.
OBJECTIVE
The aim of this multicenter trial was to compare the clinical and radiographical outcome of a ready-to-use Emdogain-gel (test) with the marketed Emdogain (control).


METHODS
Subjects with bilateral infrabony defects > or =4 mm deep and > or =2 mm wide according to radiographs were selected. 88 subjects with probing pocket depth (PPD) > or =6 mm > or =1 month after supervised oral hygiene and scaling participated. At baseline plaque index, bleeding on probing, PPD and probing attachment level were recorded and reproducible radiographs for computer-based bone level measurements were taken. In each subject, 1 tooth was randomly treated with the test and 1 tooth with the control gel. Examinations were repeated 8 and 16 months post-operatively.


RESULTS
After 16 months, the mean test PPD was 4.1 mm and the mean control PPD 4.2 mm. The mean gain of attachment was 2.7 mm for test and 2.9 mm for the control sites, and the radiographic measurements demonstrated a mean gain of 1 mm for both test and control sites.


CONCLUSIONS
This series of cases demonstrated a statistically significant reduction of pocket depths and gain of attachment and bone after 8 and 16 months with no difference between the 2 preparations.
Bratthall
G
G
Department of Periodontology, Faculty of Odontology, Malmö University, Sweden. Gunilla.Bratthall@od.mah.se
Lindberg
P
P
Havemose-Poulsen
A
A
Holmstrup
P
P
Bay
L
L
Söderholm
G
G
Norderyd
O
O
Andersson
B
B
Rickardsson
B
B
Hallström
H
H
Kullendorff
B
B
Sköld Bell
H
H
D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000704:Analysis of Variance; D002908:Chronic Disease; D003746:Dental Enamel Proteins / Q000008:administration & dosage* / Q000627:therapeutic use*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000188:drug therapy*; D011859:Radiography; D012044:Regression Analysis
D003746:Dental Enamel Proteins; D005782:Gels; C109069:enamel matrix proteins