Arc mRNA dynamics: return to sender--the NMDA receptor provides the targeting address for Arc mRNA.
The recently defined role for local protein synthesis during long-lasting synaptic plasticity has focused attention on the mechanisms underlying dendritic mRNA localization. The mRNA encoded by the immediate-early gene Arc is not only transported into dendrites, but localizes specifically to activated postsynaptic sites. This specific localization has now been shown to depend on local signaling through the NMDA receptor.
Martin
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KC
Dept of Psychiatry, UCLA Brain Research Institute, Gonda Building Rm 3506C, 695 Charles Young Dr Street, Los Angeles, CA 90095-1761, USA. kcmartin@mednet.ucla.edu
D000818:Animals; D003598:Cytoskeletal Proteins / Q000235:genetics*; D003712:Dendrites / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000502:physiology
D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; C092069:activity regulated cytoskeletal-associated protein