Application of Arene-Ruthenium Chemistry to a Formal Total Synthesis of OF 4949 III.
A convergent formal total synthesis of OF 4949 III is described. Arene-ruthenium chemistry was used in the construction of the diaryl ether linkage in high yield, and cycloamidation under high dilution conditions (0.005 M) was achieved using DPPA as coupling reagent. SmI(2) was used to reductively remove the 2-iodoethyl ester protecting group in the presence of DMPU or HMPA.
Pearson
Anthony J.
AJ
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106.
Zhang
Penglie
P
Lee
Kieseung
K