Nucleosome mobilization and positioning by ISWI-containing chromatin-remodeling factors.
ATP-dependent chromatin-remodeling machines of the SWI/SNF family are involved in many cellular processes in eukaryotic nuclei, such as transcription, replication, repair and recombination. Remodeling factors driven by the ATPase ISWI make up a subgroup of this family that exhibits defined mechanistic and functional characteristics. ISWI-induced nucleosome mobility endows nucleosomal arrays with dynamic properties and recent results suggest that ISWI-type remodelers have diverse functions that range from transcriptional regulation to chromatin assembly and maintenance of chromosome structure.
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Adolf-Butenandt-Institut, München, Germany.
Becker
P B
PB
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000201:enzymology*; D009707:Nucleosomes / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D002843:Chromatin; C086468:ISWI protein; D009707:Nucleosomes; D014157:Transcription Factors; D000251:Adenosine Triphosphatases