[Contemporary views on the etiology and pathogenesis of atherosclerosis].
Atherosclerosis is caused by a large range of exogenous and endogenous risk factors and does not result simply from the hypercholesterolemia and the accumulation of lipids. Atherogenesis is a dynamic multifactor and multi-stage inflammatory process, where different cells, cytokines and growth factors interacte as results of endothelial cell damage. This process is characterized by a focal subintimal deposition of lipids and lipoproteins in "foam cells" with a further development of chronic focal inflammation and expanditure of fibrosis, stenosis of the arterial lumen and development of further organ complications. The same are found in 50% of the patients, affected by atherosclerosis and are at the root of the death-rate in USA and Europe.
Draganov
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V
Balutsov
M
M
Lazarov
S
S
D001158:Arteries / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D003251:Constriction, Pathologic / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology; D005355:Fibrosis / Q000503:physiopathology; D005487:Foam Cells / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D006937:Hypercholesterolemia / Q000503:physiopathology; D007249:Inflammation / Q000150:complications* / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism
D016207:Cytokines; D006133:Growth Substances; D008077:Lipoproteins, LDL