[Beta 2-Adrenergic receptor gene polymorphisms].
beta 2-adrenergic receptor gene is an intronless single gene coding 413 amino acid and is located on chromosome 5q31-33. This area is also noted as a candidate locus for asthma susceptibility genes. Up to now, 9 polymorphisms in the coding lesion and 10 polymorphisms in the 5' promotor lesion have been reported. Some of them have functional significance. In terms of both pathophysiological and pharmacogenetic view of asthma, these polymorphisms have been attracted an attention of many researchers. In this review, I will summarize the recent knowledge about this topic and discuss some future directions.
Munakata
M
M
Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University.
D000595:Amino Acid Sequence; D002895:Chromosomes, Human, Pair 5; D015536:Down-Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D008969:Molecular Sequence Data; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry / Q000235:genetics*
D018343:Receptors, Adrenergic, beta-2