title: The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.
abstract: We have isolated cDNAs for three members of a family of seven-pass transmembrane cadherins in mouse (Celsr1, 2 and 3). These three genes represent vertebrate homologues of flamingo/starry night, recently identified as an essential component of the Drosophila planar cell polarity pathway and for the correct formation of dendritic fields within the Drosophila peripheral nervous system. In this study, we show that each member of the mouse Celsr family exhibit distinct patterns of expression within a range of different tissues within the developing embryo. Celsr1 and Celsr2 expression is observed during gastrulation and within the developing nervous system. Celsr3 transcripts, however, are found only at sites of active neurogenesis.
authors.affiliation: Department of Biochemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, SW7 2AZ, London, UK. caroline.formstone@kcl.ac.uk
authors.forename: C J
authors.initials: CJ
authors.lastname: Formstone
authors.forename: P F
authors.initials: PF
authors.lastname: Little
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics*; D004330:Drosophila; D029721:Drosophila Proteins; D005314:Embryonic and Fetal Development; D005326:Fetal Proteins; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice; D011956:Receptors, Cell Surface / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled
chemical_list: C498477:CELSR2 protein, human; D015820:Cadherins; C117380:Celsr1 protein, mouse; C498478:Celsr2 protein, mouse; C444454:Celsr3 protein, mouse; D029721:Drosophila Proteins; D005326:Fetal Proteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C121420:stan protein, Drosophila