title: A selectively deprotectable triazacyclophane scaffold for the construction of artificial receptors.
abstract: [reaction: see text]. The synthesis of a triazacylclophane scaffold bearing a set of selectively removable protecting groups is described. This versatile scaffold, which can be linked to a solid support, allows the attachment of three different side chains and can therefore be used for the combinatorial synthesis of libraries of artificial receptor molecules of high structural diversity.
authors.affiliation: Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Opatz
authors.forename: R M
authors.initials: RM
authors.lastname: Liskamp
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D004151:Dipeptides / Q000737:chemistry; D006020:Glycopeptides / Q000737:chemistry*; D007202:Indicators and Reagents; D008024:Ligands; D018716:Molecular Mimicry; D018000:Receptors, Peptide / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D004151:Dipeptides; D006020:Glycopeptides; D007202:Indicators and Reagents; D008024:Ligands; D018000:Receptors, Peptide; C002956:alanylalanine