title: Urine interleukin-8 is a marker for urinary tract infection in postoperative patients.
abstract: BACKGROUND
  Urine of patients with urinary tract infection (UTI) contains high levels of interleukin (IL)-6 and IL-8. However, knowledge of the kinetics of their release in urine is limited. We therefore compared the appearance of IL-6 and IL-8 in urine after uncomplicated surgery and surgery complicated by UTI.
  
  
  METHODS
  165 patients undergoing abdominal surgery who received a urinary catheter were studied. Urine IL-6 and IL-8 were prospectively measured in patients who did (n = 10) or did not (n = 20) develop UTI. Statistical analysis was done by one-way ANOVA and the Mann-Whitney test.
  
  
  RESULTS
  Although urine IL-6 increased in the 2 to 4 days preceding the bacteriological documentation of UTI, a similar increase was observed in patients who did not develop UTI. Urine IL-8 was elevated on the day UTI was diagnosed, while remaining low in controls.
  
  
  CONCLUSIONS
  In this patient group with postoperative UTI, urine IL-8 was a better marker for the early host response than urine IL-6.
authors.affiliation: Dept. of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: D P
authors.initials: DP
authors.lastname: Olszyna
authors.forename: H
authors.initials: H
authors.lastname: Vermeulen
authors.forename: A H
authors.initials: AH
authors.lastname: Baan
authors.forename: P
authors.initials: P
authors.lastname: Speelman
authors.forename: S J
authors.initials: SJ
authors.lastname: van Deventer
authors.forename: D J
authors.initials: DJ
authors.lastname: Gouma
authors.forename: T
authors.initials: T
authors.lastname: van der Poll
mesh_terms: D000005:Abdomen / Q000601:surgery; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000652:urine; D016209:Interleukin-8 / Q000652:urine*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012680:Sensitivity and Specificity; D014546:Urinary Catheterization / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000209:etiology
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D016209:Interleukin-8