A novel cyclin provides a link between dopamine and RNA processing.
Regulation of gene expression by dopamine may play an important role in learning, reward, and addiction. Hyman and colleagues now report the characterization of ania-6, a novel cyclin that associates with RNA polymerase II and is induced by dopamine or cocaine in the neostriatum. Ania-6 may thus provide a link between dopamine and gene expression at the level of mRNA processing.
Nairn
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Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA.
Greengard
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D017398:Alternative Splicing; D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D016213:Cyclins / Q000235:genetics* / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D012319:RNA Polymerase II / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*
D016213:Cyclins; D012333:RNA, Messenger; D012319:RNA Polymerase II; D003042:Cocaine; D004298:Dopamine