Adverse events in peripheral progenitor cell collection: a 7-year experience.
Collection of peripheral progenitor cells (PPC) by apheresis machines is generally regarded as a safe procedure. However, data about adverse events in PPC harvesting are scarce. In a monocentric retrospective study, the data of 540 PPC collections in a period of 7 years were reviewed. Adverse events were subdivided in collection-associated technical problems and patient/donor-related side effects. Patient/donor-related side effects occurred most often (19.8%); most of them were paresthesias due to citrate toxicity. Paresthesias were treated by oral (20.4%) or intravenous (1.1%) calcium supplementation. Problems with venous access were also seen frequently, resulting in blood flow alarms (11.3%) and blockades in the return line (4.3%). A total of 6.9% of these problems were catheter associated, requiring revision of the central venous line in 2.6%. Technical problems with the blood cell separators were observed in 11.7%. Ten PPC collections were discontinued due to adverse events. The data of this retrospective, monocentric analysis show that patient/donor-associated problems were observed in every fifth PPC harvest. Most of them were paresthesias, which could be easily treated by calcium supplementation. Problems with venous access and technical problems with the cell separators occurred in every tenth PPC collection.
Moog
R
R
Institute for Transfusion Medicine, University Clinics Essen, Germany. rainer.moog@uni-essen.de
D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D001781:Blood Component Removal / Q000009:adverse effects* / Q000295:instrumentation / Q000706:statistics & numerical data; D001782:Blood Donors; D002404:Catheterization / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D006406:Hematoma / Q000209:etiology; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007022:Hypotension / Q000209:etiology; D007223:Infant; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010292:Paresthesia / Q000209:etiology; D018962:Phlebotomy / Q000009:adverse effects; D012189:Retrospective Studies; D014839:Vomiting / Q000209:etiology