Secondary metabolites from Basotho medicinal plants. I. Bulbine narcissifolia.
The medicinal plant Bulbine narcissifolia is used by the Basotho, Griqua, and whites of southern Africa for wound healing and as a mild purgative. Extraction of the powdered root has yielded acetosyringone, chrysophanol, knipholone, isoknipholone, 10,7'-bichrysophanol, and chrysalodin in addition to two new anthraquinone glycosides, knipholone-8-O-beta-D-gentiobioside (1) and chrysalodin-10-beta-D-gentiobioside (2). NMR spectroscopy was used to elucidate the structures of 1 and 2 and to show that 1 binds weakly to DNA.
Qhotsokoane-Lusunzi
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MA
Department of Chemistry, Macquarie University, Sydney NSW 2109, Australia.
Karuso
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D000098:Acetophenones / Q000737:chemistry / Q000302:isolation & purification; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification*; D007927:Lesotho; D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013019:South Africa; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014945:Wound Healing
D000098:Acetophenones; D000880:Anthraquinones; D004187:Disaccharides; C440973:chrysalodin-10-gentiobioside; C403586:knipholone; C440974:knipholone-8-O-gentiobioside; C051667:acetosyringone; D004247:DNA; C027113:chrysophanic acid