Total Synthesis of (+/-)-Cylindricines A and B.
Cylindricine A (1) and cylindricine B (2) have been synthesized in 11 steps and 19% overall yield. The key reaction involves the addition of an organocopper species to a bicyclic vinylogous amide, which provides complete stereocontrol over the installation of the hexyl side chain.
Liu
Julie Fields
JF
Department of Chemistry, University of California, Berkeley, California, 94720.
Heathcock
Clayton H.
CH