Myelodysplastic syndrome accompanied by Addison's disease and multiple autoimmune phenomena: steroid therapy resolved cytopenias and all immune disorders.
We report here a patient with myelodysplastic syndromes (MDS), which was complicated with several autoimmune disorders and asymptomatic immunologic abnormalities. An 82-year-old woman with refractory anemia (RA) rapidly developed thrombocytopenia with the appearance of symptoms such as purpura, fatigue, anorexia, and weight loss. Furthermore, clinical examinations revealed that she also had Addison's disease, rheumatoid arthritis, and autoimmune hematological diseases such as thrombocytopenia and hemolytic anemia. However, the cytopenia and all autoimmune disorders were remarkably improved after she received steroid therapy.
Funato
K
K
First Department of Internal Medicine, Tokyo Medical University.
Kuriyama
Y
Y
Uchida
Y
Y
Suzuki
A
A
Miyazawa
K
K
Ohyashiki
K
K
D000224:Addison Disease / Q000150:complications* / Q000175:diagnosis; D000368:Aged; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000175:diagnosis; D011241:Prednisone / Q000627:therapeutic use*; D011379:Prognosis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D012307:Risk Factors; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D011241:Prednisone