title: Scintigraphy in the detection of gastro-oesophageal reflux in children with caustic oesophageal burns: a comparative study with radiography and 24-h pH monitoring.
abstract: BACKGROUND
  Caustic injury of the oesophagus not only causes luminal narrowing but is also responsible for longitudinal contraction, resulting in gastro-oesophageal reflux (GOR), which leads to failure of conventional therapy. Therefore, the development of GOR should be investigated periodically to direct appropriate management of these patients.
  
  
  OBJECTIVE
  To determine the ability of scintigraphy to detect GOR in children with caustic oesophageal strictures in comparison with barium study and 24-h pH monitoring.
  
  
  METHODS
  Seventeen children with caustic oesophageal injury underwent scintigraphy, an upper GI barium study and 24-h pH monitoring within the same week. Five patients were also investigated post-operatively for the assessment of surgical outcome after antireflux surgery.
  
  
  RESULTS
  On the whole, there was good correlation (r = 0.78, P < 0.00 l) between scintigraphy and 24-h oesophageal pH monitoring. Scintigraphy detected all but one (9/10) refluxing patients and also correctly identified all (7/7) non-refluxing patients. Barium studies demonstrated 6 out of 10 refluxing patients. There were no false-positive barium studies in non-refluxing patients. Post-operative studies demonstrated no evidence of GOR in surgically treated patients.
  
  
  CONCLUSIONS
  Our results indicate that, by comparison with barium studies, scintigraphy is useful in the detection of GOR in cases with caustic oesophageal strictures and may be used as a screening modality for those under clinical follow-up.
authors.affiliation: Department of Nuclear Medicine, Ege University Medical Faculty, 35100-Bornova, Izmir, Turkey. zehraozcan@ixir.com
authors.forename: Z
authors.initials: Z
authors.lastname: Ozcan
authors.forename: C
authors.initials: C
authors.lastname: Ozcan
authors.forename: R
authors.initials: R
authors.lastname: Erinç
authors.forename: A
authors.initials: A
authors.lastname: Dirlik
authors.forename: O
authors.initials: O
authors.lastname: Mutaf
mesh_terms: D000293:Adolescent; D002057:Burns, Chemical / Q000150:complications*; D002424:Caustics / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004940:Esophageal Stenosis / Q000139:chemically induced / Q000150:complications*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D018670:Monitoring, Ambulatory / Q000379:methods
chemical_list: D002424:Caustics