Synthesis of 10,11-Dihydro-12-oxo-LTB(4), a Key Biochemical Intermediate.
The first total synthesis of the 5(S)-hydroxy-10,11-dihydro-12-oxo-6(Z),8(E),14(Z)-eicosatrienoic acid (10,11-dihydro-12-oxo-LTB(4)) (3) is reported. This compound is a key pivotal intermediate in the biotransformation of LTB(4) by the so-called "LTB(4) reductase pathway".
Khanapure
Subhash P.
SP
Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 W. University Boulevard, Melbourne, Florida 32901 and Meakins-Christie Laboratories, McGill University, 3626 St-Urbain Street, Montreal, Quebec H2X 2P2, Canada.
Wang
Steven S.
SS
Powell
William S.
WS
Rokach
Joshua
J