Effect of Mahonia aquifolium stem bark crude extract and one of its polysaccharide components on production of IL-8.
The crude hydroalcoholic extract of Mahonia aquifolium stem bark and a polysaccharide isolated from the extract were tested for their activity on interleukin-8 (IL-8) production by human monocytic cell line THP-1. The crude extract partly inhibited the IL-8 spontaneous production after 48-h treatment of the cells, while the polysaccharide was found to be a potent inducer of IL-8 production.
Kost'álová
D
D
Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, SK-823 32 3, Bratislava, Slovakia. kostalova@fpharm.uniba.sk
Kardosová
A
A
Hajnická
V
V
D028141:Berberidaceae; D002460:Cell Line / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis*; D009000:Monocytes / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*
D016209:Interleukin-8; D010936:Plant Extracts; D011134:Polysaccharides