Total Synthesis of Bistratamide D.
The total synthesis of the macrocyclic hexapeptide bistratamide D is reported. The synthetic strategy involved assembly of enantiomerically pure oxazole, thiazole, and oxazoline segments derived from amino acids. Macrocyclization of the hexapeptidic aminooxazoline-oxazole-thiazole carboxylic acid fragment was accomplished by activation with O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU).
Downing
Susan V.
SV
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523.
Aguilar
Enrique
E
Meyers
A. I.
AI