Research on new AMPA antagonists of 2,3-benzodiazepine type.
In this review on the most interesting studies and discoveries made during our structure-activity relationship investigations with non-competitive AMPA antagonists of 2,3-benzodiazepine type, our chain of ideas is discussed which led to several new types of active non-competitive AMPA antagonists. Some selected compounds (e.g. GYKI-47261) exerting broad spectrum of anticonvulsive and excellent neuroprotective effects are being further investigated.
Sólyom
S
S
Institute for Drug Research, Ltd, Budapest.
D000818:Animals; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D006814:Hungary; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*
D018691:Excitatory Amino Acid Antagonists; D018091:Receptors, AMPA; D001569:Benzodiazepines