title: [Multiple sclerosis: spontaneous course, natural history].
abstract: Globally, the course and prognosis of multiple sclerosis are heterogeneous, and generally considered to be unpredictable. Advances in statistical techniques have made it possible to analyze representative cohorts of patients to clearly delineate the overall prognosis of the disease, beyond individual variations. For each individual however, there appears to be a steady progression as shown by serial quantified neurological examinations. At the present time early prediction of outcome remains impossible. In the near future, new imaging techniques may provide a solution to this problem allowing selection of patients at risk who could benefit from early treatment.
authors.affiliation: Service du Neurologie A, Pr Ch. Confavreux, Hôpital Neurologique Pierre Wertheimer 59, boulevard Pinel, 69003 Lyon, France. sandra.vukusic@wanadoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Vukusic
authors.forename: T
authors.initials: T
authors.lastname: Moreau
authors.forename: F
authors.initials: F
authors.lastname: Bouhour
authors.forename: P
authors.initials: P
authors.lastname: Adeleine
authors.forename: C
authors.initials: C
authors.lastname: Confavreux
mesh_terms: D003952:Diagnostic Imaging; D004185:Disability Evaluation; D006801:Humans; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis* / Q000188:drug therapy; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis* / Q000188:drug therapy; D009460:Neurologic Examination; D011379:Prognosis