title: A novel cyclin provides a link between dopamine and RNA processing.
abstract: Regulation of gene expression by dopamine may play an important role in learning, reward, and addiction. Hyman and colleagues now report the characterization of ania-6, a novel cyclin that associates with RNA polymerase II and is induced by dopamine or cocaine in the neostriatum. Ania-6 may thus provide a link between dopamine and gene expression at the level of mRNA processing.
authors.affiliation: Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Nairn
authors.forename: P
authors.initials: P
authors.lastname: Greengard
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D016213:Cyclins / Q000235:genetics* / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D012319:RNA Polymerase II / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D016213:Cyclins; D012333:RNA, Messenger; D012319:RNA Polymerase II; D003042:Cocaine; D004298:Dopamine