Age-associated increase of 8-hydroxydeoxyguanosine in human colorectal tissue DNA.
To clarify the role of oxidative stress in aging of colorectal tissue, we analyzed the 8-hydroxydeoxyguanosine (8-OH-dG) levels in colorectal biopsy samples from normal tissue of patients with either colorectal cancer (n = 15) or benign colorectal polyps (n = 40). An age-associated increase of 8-OH-dG was observed (p =.002), although the 8-OH-dG levels were not significantly different between the patients with cancer and those with polyps. These results suggest an increased level of 8-OH-dG formation in human colorectal tissue with age.
Tsurudome
Y
Y
Departments of Environmental Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hirano
T
T
Hirata
K
K
Higure
A
A
Nagata
N
N
Takahashi
K
K
Itoh
H
H
Kasai
H
H
D000080242:8-Hydroxy-2'-Deoxyguanosine / Q000031:analogs & derivatives; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D003106:Colon / Q000378:metabolism*; D003111:Colonic Polyps / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D006147:Guanine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007417:Intestinal Polyps / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress; D012007:Rectum / Q000378:metabolism*
D006147:Guanine; C078307:8-oxo-7,8-dihydrodeoxyguanine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA