The evidence for glutamine use in the critically-ill.
Research into the metabolic role of glutamine in trauma and sepsis brings evidence to suggest a conditional deficiency occurs because increased and altered tissue demands exceed endogenous production. Such a deficiency has functional implications, and the restorative provision of parenteral glutamine has been shown to offer improved clinical outcomes in a variety of conditions. In the critically-ill it is associated with improvements in immune function, and improved survival from infection leading to an overall improved outcome.
Griffiths
R D
RD
Intensive Care Research Group, Department of Medicine, University of Liverpool, UK. rdg@liverpool.ac.uk
D016638:Critical Illness / Q000628:therapy*; D005973:Glutamine / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000378:metabolism; D009017:Morbidity; D018482:Muscle, Skeletal / Q000378:metabolism
D005973:Glutamine