title: Response of metastatic epidermoid anal cancer to single agent irinotecan: a case report.
abstract: We report a case of a patient affected by epidermoid anal cancer who had hepatic progression after standard therapy with the Nigro regimen (fluorouracil and mitomycin C plus radiotherapy). This is an uncommon neoplasm against which only few chemotherapeutic agents have been tested. In our patient salvage treatment with low dose irinotecan resulted in a partial response.
authors.affiliation: Department of Experimental Medicine, University La Sapienza, Policlinico Umberto I, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Grifaichi
authors.forename: A
authors.initials: A
authors.lastname: Padovani
authors.forename: F
authors.initials: F
authors.lastname: Romeo
authors.forename: C
authors.initials: C
authors.lastname: Trinca
authors.forename: L
authors.initials: L
authors.lastname: Moscetti
authors.forename: E
authors.initials: E
authors.lastname: Cortesi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000556:secondary; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin