title: Correlation of CD4(+) T-Cell counts estimated by an immunocapture technique (Capcellia) with viral loads in human immunodeficiency virus-seropositive individuals.
abstract: As antiretroviral therapy becomes more affordable, valid, reliable, and inexpensive laboratory tests are also needed to monitor the progression of disease in people with human immunodeficiency virus (HIV) infection. The CD4(+) T-cell counts estimated by Capcellia, an immunocapture method, and flow cytometry were compared and were correlated with HIV type 1 (HIV-1) load. There was a significant negative correlation between the HIV-1 load and CD4(+) T-cell counts estimated by flow cytometry (r = -0.63, P = <0.001) as well as between the HIV-1 load and CD4(+) T-cell counts estimated by Capcellia (r = -0.61, P = <0.001). Capcellia is a cost-effective, user-friendly assay that correlated well with HIV-1 load determinations for individuals both with and without treatment.
authors.affiliation: Department of Clinical Virology, Christian Medical College Hospital, Vellore 632004, India.
authors.forename: R
authors.initials: R
authors.lastname: Kannangai
authors.forename: S
authors.initials: S
authors.lastname: Ramalingam
authors.forename: M V
authors.initials: MV
authors.lastname: Jesudason
authors.forename: T S
authors.initials: TS
authors.lastname: Vijayakumar
authors.forename: O C
authors.initials: OC
authors.lastname: Abraham
authors.forename: A
authors.initials: A
authors.lastname: Zachariah
authors.forename: G
authors.initials: G
authors.lastname: Sridharan
mesh_terms: D000328:Adult; D016516:CD4-CD8 Ratio; D005260:Female; D005434:Flow Cytometry / Q000379:methods*; D015658:HIV Infections / Q000175:diagnosis / Q000276:immunology*; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load