title: Age-associated increase of 8-hydroxydeoxyguanosine in human colorectal tissue DNA.
abstract: To clarify the role of oxidative stress in aging of colorectal tissue, we analyzed the 8-hydroxydeoxyguanosine (8-OH-dG) levels in colorectal biopsy samples from normal tissue of patients with either colorectal cancer (n = 15) or benign colorectal polyps (n = 40). An age-associated increase of 8-OH-dG was observed (p =.002), although the 8-OH-dG levels were not significantly different between the patients with cancer and those with polyps. These results suggest an increased level of 8-OH-dG formation in human colorectal tissue with age.
authors.affiliation: Departments of Environmental Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tsurudome
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: A
authors.initials: A
authors.lastname: Higure
authors.forename: N
authors.initials: N
authors.lastname: Nagata
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: H
authors.initials: H
authors.lastname: Kasai
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine / Q000031:analogs & derivatives; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D003106:Colon / Q000378:metabolism*; D003111:Colonic Polyps / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D006147:Guanine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007417:Intestinal Polyps / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress; D012007:Rectum / Q000378:metabolism*
chemical_list: D006147:Guanine; C078307:8-oxo-7,8-dihydrodeoxyguanine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA