title: Diastereoselective Synthesis of Cyclopentanoids with Hydantoin and Isoxazoline Substituents.
abstract: Exploiting 1,3-dipolar cycloaddition and urea --> hydantoin cyclization transformations, novel spiro[cyclopenta[d]isoxazole-4',5-imidazolindine] heterocycles of generalized structure I have been prepared. The 1-amino-3-cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis-1,4-dichloro-2-butene.
authors.affiliation: Department of Chemistry, University of California, Davis, California 95616.
authors.forename: Kyung-Ho
authors.initials: KH
authors.lastname: Park
authors.forename: Marilyn M.
authors.initials: MM
authors.lastname: Olmstead
authors.forename: Mark J.
authors.initials: MJ
authors.lastname: Kurth