title: Non-Photochemical Route to Chiral Disubstituted [7]Thiaheterohelicenes via Biaryl- and Carbonyl-Coupling Reactions.
abstract: Non-photochemical syntheses of optically active dimethyl[7]thiaheterohelicenes (P)-(+)-14 and (M)-(-)-14 are described. The key transformations in the syntheses are the metal-mediated biaryl coupling reactions between two benzodithiophene units having oxazoline moieties and the intramolecular McMurry coupling reaction of the biaryl dialdehydes (S)-13 and (R)-13. The configuration of the atropisomer 10a obtained from the biaryl coupling reaction was shown to be S by X-ray analysis.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-01, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Hitomi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Hideji
authors.initials: H
authors.lastname: Osuga