The effects of the selective serotonin reuptake-inhibitor fluvoxamine on body weight in Zucker rats are mediated by corticotropin-releasing hormone.
Brain serotonin plays a crucial role in the regulation of food intake and body weight homeostasis. Previous data suggest an interaction with corticotropin-releasing hormone (CRH). To further examine the interaction between these neurotransmitters, the selective serotonin reuptake-inhibitor (SSRI) fluvoxamine was given intraperitoneally in fa/fa Zucker rats with and without the CRH-receptor-antagonist alpha-helical CRH administered intracerebroventricularly (i.c.v.). The saline treated animals gained weight. Fluvoxamine led to a significant weight loss while not affecting food intake. Furthermore, insulin levels in this animal model were reduced following fluvoxamine administration. These effects were antagonized by alpha-helical CRH and are thus most likely mediated via CRH or CRH-like peptides.
Wieczorek
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Department of Endocrinology and Metabolism, Otto-von-Guericke University, Magdeburg, Germany.
Schulz
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C
Jarry
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Lehnert
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H
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D004435:Eating / Q000187:drug effects; D016666:Fluvoxamine / Q000494:pharmacology*; D006727:Hormone Antagonists; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011924:Rats, Zucker; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D015431:Weight Loss / Q000187:drug effects*
D003346:Corticotropin-Releasing Hormone; D016666:Fluvoxamine; D006727:Hormone Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; C069206:alpha helical corticotropin-releasing hormone