title: Graphical and stereolithographic models of the developing human heart lumen.
abstract: Scaled physical models can be useful in analyzing stage-specific hemodynamics in the embryonic human heart to address correlations between early physical stressors and myocardial wall responses. We generated models of the cardiac blood space from reconstructions of four digitized human embryo images from Carnegie Collection at the Armed Forces Institute of Pathology. From physical scale models manufactured by stereolithography, compliant sleeves can be created for flow dynamics studies. This novel use of Carnegie collection images and graphical modeling software provides tools for broadening our understanding of normal and aberrant heart formation.
authors.affiliation: Oregon Health Sciences University, Congenital Heart Research Center, 3181 SW Sam Jackson Park Road, L464, Portland, OR 97201, USA. pentecos@ohsu.edu
authors.forename: J O
authors.initials: JO
authors.lastname: Pentecost
authors.forename: D J
authors.initials: DJ
authors.lastname: Sahn
authors.forename: B L
authors.initials: BL
authors.lastname: Thornburg
authors.forename: M
authors.initials: M
authors.lastname: Gharib
authors.forename: A
authors.initials: A
authors.lastname: Baptista
authors.forename: K L
authors.initials: KL
authors.lastname: Thornburg
mesh_terms: D005314:Embryonic and Fetal Development / Q000502:physiology; D006321:Heart / Q000196:embryology* / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008953:Models, Anatomic; D012039:Regional Blood Flow; D012984:Software