Synthesis of Dihydroisoxazole Nucleoside and Nucleotide Analogs.
The dihydroisoxazole nucleosides as well as their phosphonate derivatives were efficiently prepared via 1,3-dipolar cycloaddition reactions of nitrile oxides with corresponding vinyl nucleoside bases for antiviral studies.
Gi
Hung-Jang
HJ
Department of Chemistry, New York University, New York, New York 10003, Georgia Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur, Georgia 30033, and Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322.
Xiang
Yuejun
Y
Schinazi
Raymond F.
RF
Zhao
Kang
K