Hypothyroidism and nutritional status alter 3,5,3'-triiodothyronine (T3) receptors in isolated liver nuclei of Anabas testudineus (Bloch).
T3 receptors are ligand-dependent transcriptional activators that can stimulate gene expression resulting in growth and development. In this study T3 binding sites on isolated liver nuclei are demonstrated in the teleost Anabas testudineus. The effect of hypothyroidism and feeding of polyunsaturated fatty acids (PUFA) on T3 receptor number and binding affinity was also studied. Hypothyroidism caused an increase in T3 receptor number and a decrease in receptor affinity. PUFA feeding also increased the T3 receptor number without any significant change in its receptor affinity.
Shameena
B
B
Department of Zoology, University of Kerala, Trivandrum, Kerala, India.
Renuka
T R
TR
Varghese
S
S
Paulose
C S
CS
Oommen
O V
OV
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005260:Female; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure*; D010473:Perciformes; D011441:Propylthiouracil / Q000494:pharmacology*; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology*
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D011988:Receptors, Thyroid Hormone; D011441:Propylthiouracil