title: DNA replication: partners in the Okazaki two-step.
abstract: The correct processing of Okazaki fragments during lagging-strand DNA replication has a vital role in maintaining genome integrity. Recent findings suggest that, in eukaryotes, the processing of Okazaki fragments occurs by a two-step mechanism governed by the single-stranded DNA binding factor RPA.
authors.affiliation: Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, EH9 3JR, Edinburgh, UK. s.a.macneill@ed.ac.uk
authors.forename: S A
authors.initials: SA
authors.lastname: MacNeill
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D004265:DNA Helicases / Q000378:metabolism; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000378:metabolism; D019915:DNA Primase / Q000378:metabolism*; D004261:DNA Replication / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004706:Endodeoxyribonucleases / Q000378:metabolism; D005057:Eukaryotic Cells / Q000502:physiology*; D045585:Flap Endonucleases; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D051716:Replication Protein A; D051818:Replication Protein C; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; C022262:Okazaki fragments; D018809:Proliferating Cell Nuclear Antigen; D051716:Replication Protein A; D029701:Saccharomyces cerevisiae Proteins; D004247:DNA; D019915:DNA Primase; D004706:Endodeoxyribonucleases; D045585:Flap Endonucleases; D000251:Adenosine Triphosphatases; D004265:DNA Helicases; D051818:Replication Protein C; C410222:DNA2 protein, S cerevisiae; D011088:DNA Ligases; D000072481:DNA Ligase ATP