title: Dose resolution optimization of polymer gel dosimeters using different monomers.
abstract: Polymer gel dosimeters of different formulations were manufactured from different monomers of acrylamide, acrylic acid, methacrylic acid, 1-vinyl-2-pyrrolidinone, 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate. Gelatin and agarose were used as the gelling agents and N,N'-methylene-bis-acrylamide was used as a co-monomer in each polymer gel dosimeter. The T2 dependence of each dosimeter was analysed using a model of fast exchange of magnetization. The influence of the half-dose and the apparent T2 of the polymer-proton pool on the dose resolution (Dpdelta) were examined. Comparisons are made with the commonly employed R2-dose sensitivity. Differences exist suggesting that experiments reported in the literature using what were thought to be more optimal dosimeters may not actually be so. Based on Dpdelta of each formulation, conclusions are drawn on the optimal formulation required for a specific range of absorbed doses. In addition, information about the extent of polymerization of the monomers used along with some characteristics of the polymer network formed are reported. The influence of the concentration of monomers and gelling agent was subsequently evaluated using a model of fast exchange of magnetization. Based on these calculations, further improvement in Dpdelta can be expected.
authors.affiliation: Centre for Medical, Health and Environmental Physics, Queensland University of Technology, Brisbane, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Lepag
authors.forename: P M
authors.initials: PM
authors.lastname: Jayasakera
authors.forename: S A
authors.initials: SA
authors.lastname: Bäck
authors.forename: C
authors.initials: C
authors.lastname: Baldock
mesh_terms: D020106:Acrylamide / Q000737:chemistry; D000179:Acrylates / Q000737:chemistry; D004307:Dose-Response Relationship, Radiation; D005782:Gels / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D008689:Methacrylates / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011522:Protons; D011760:Pyrrolidinones / Q000737:chemistry; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*
chemical_list: D000179:Acrylates; D005782:Gels; D008689:Methacrylates; D011108:Polymers; D011522:Protons; D011760:Pyrrolidinones; C008384:methacrylic acid; D020106:Acrylamide; C035957:2-hydroxyethyl acrylate; C005044:hydroxyethyl methacrylate; C042670:N-vinyl-2-pyrrolidinone; C036658:acrylic acid