Combined implantation of particulate dentine, plaster of Paris, and a bone xenograft (Bio-Oss) for bone regeneration in rats.
The purpose of this study is to assess the combination of particulate dentine and plaster as bone substitute material in calvarial bone defects in rats, and to compare it with a bone xenograft (Bio-Oss).


METHODS
Forty rats were assigned randomly to five groups and each group was further divided into two subgroups, 8 and 16 weeks after implantation. The defect was filled with different graft materials in each group: Group 1, defects were filled with particulate dentine and plaster using a 2:1 ratio; Group 2, defects were filled with particulate dentine; plaster, and Bio-Oss using a 2:1:1 ratio; Group 3, defects were filled with plaster and Bio-Oss using a 1:1 ratio; Group 4, defects were filled with Bio-Oss only; and Group 5, untreated control defects. Histological sections and histomorphometric analysis of defects were obtained at 8 and 16 weeks postoperatively.


RESULTS
New bone formation was highest in Group 4, followed by Group 3, than Group 2, Group 1, and finally the control group.


CONCLUSIONS
The combination of particulate dentine and plaster is an alternative bone substitute, although it is less effective than Bio-Oss.
Su-Gwan
K
K
Department of Oral and Maxillofacial Surgery, Oral Biology Research Institute, Chosun University, Kwang-Ju, Korea. SGCKIM@mail.chosun.ac.kr
Hak-Kyun
K
K
Sung-Chul
L
L
D000704:Analysis of Variance; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D002133:Calcium Sulfate; D003804:Dentin; D008903:Minerals; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull / Q000601:surgery; D018709:Statistics, Nonparametric
C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals; D002133:Calcium Sulfate