title: Synthesis of macrotetrolide alpha, a designed polynactin analog composed of (+)- and (-)-bishomononactic acids.
abstract: Macrotetrolide alpha, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resolution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide alpha took seven steps without any loss of the intermediates.
authors.affiliation: Division of Life Science, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hanadate
authors.forename: H
authors.initials: H
authors.lastname: Kiyota
authors.forename: T
authors.initials: T
authors.lastname: Oritani
mesh_terms: D001671:Biochemistry / Q000379:methods*; D002352:Carrier Proteins / Q000737:chemistry*; D005663:Furans / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D011422:Propionates / Q000737:chemistry
chemical_list: D002352:Carrier Proteins; D005663:Furans; D007783:Lactones; D011422:Propionates; C453477:bishomononactic acid; C033135:gelatin binding protein; C453476:macrotetrolide alpha