Impairment of human sperm motility and viability by quercetin is independent of lipid peroxidation.
Human sperm motility, viability and lipid peroxidation were assessed in Ringer-Tyrode supplemented with different concentrations of quercetin. An irreversible and dose-dependent fall in sperm motility was observed with quercetin (5-200 microm). However, sperm viability was decreased only at higher concentrations (50-100 microm) of quercetin. This inhibition in sperm motility and viability has been linked with decreased Ca2+-ATPase activity, as there was no effect of quercetin on sperm lipid peroxidation.
Khanduja
K L
KL
Department of Biophysics, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India. medinst@pgi.chd.nic.in
Verma
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Bhardwaj
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A
D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011794:Quercetin / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology
D011794:Quercetin; D000252:Calcium-Transporting ATPases