title: Bioavailability of iron bis-glycinate chelate in water.
abstract: Iron amino acid chelate is being increasingly considered in programs for iron fortification of foods. The bioavailability of iron bis-glycinate chelate given in water was studied using a double-isotopic method in a group of 14 women. Iron absorption from aqueous solutions of 15 mg/L of elemental iron as either iron bis-glycine chelate or ferrous ascorbate was not significantly different (34.6% and 29.9% respectively). Standardized iron absorption of the iron bis-glycinate was 46.3% (standardized to 40% absorption of the reference dose). There was a significant correlations between (ln) iron absorption of iron bis-glycinate chelate with (ln) serum ferritin (r = -0.60, p < 0.03) and with (ln) iron absorption from ferrous ascorbate (r = 0.71, p < 0.006), suggesting that iron bis-glycinate chelate absorption is indeed regulated by the iron stores of the body.
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile.
authors.forename: M
authors.initials: M
authors.lastname: Olivares
authors.forename: F
authors.initials: F
authors.lastname: Pizarro
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000493:pharmacokinetics; D001205:Ascorbic Acid / Q000493:pharmacokinetics; D001682:Biological Availability; D004326:Drinking; D005260:Female; D005293:Ferritins / Q000097:blood / Q000493:pharmacokinetics; D005296:Ferrous Compounds / Q000097:blood / Q000493:pharmacokinetics*; D005527:Food, Fortified; D005998:Glycine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007502:Iron Chelating Agents / Q000493:pharmacokinetics*; D007503:Iron Isotopes; D008875:Middle Aged; D014867:Water
chemical_list: D000975:Antioxidants; D005296:Ferrous Compounds; D007502:Iron Chelating Agents; D007503:Iron Isotopes; C073588:bis-glycino iron II; D014867:Water; D005293:Ferritins; D001205:Ascorbic Acid; D005998:Glycine