title: New twists in understanding the fate of antisense oligodeoxynucleotide mRNA targets.
abstract: In this issue of Molecular Cell, Thoma et al. show that after a target mRNA is cleaved, upon treatment with an antisense oligodeoxynucleotide, the 3' cleavage product persists and is translated to produce an N-terminally truncated version of the protein encoded by the target mRNA.
authors.affiliation: Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Steiger
authors.forename: C J
authors.initials: CJ
authors.lastname: Decker
mesh_terms: D000818:Animals; D039603:Eukaryotic Initiation Factor-4G; D006801:Humans; D020319:Oligodeoxyribonucleotides, Antisense / Q000378:metabolism*; D010448:Peptide Initiation Factors / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D016914:Ribonuclease H / Q000378:metabolism; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D039603:Eukaryotic Initiation Factor-4G; D020319:Oligodeoxyribonucleotides, Antisense; D010448:Peptide Initiation Factors; D012333:RNA, Messenger; D016914:Ribonuclease H