Effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on leukocyte count and survival rate of dogs with parvoviral enteritis.
Dogs with clinical signs consistent with parvoviral enteritis and leukopenia (total leukocyte count < 5.0 x 10(9) l(-1)) were included in this randomised double-blind study (treatment group: n = 22; control group: n = 21). The dogs in the treatment group received a subcutaneous daily injection of 10 microg kg(-1) of recombinant human granulocyte colony-stimulating factor (rhG-CSF) for 5 days. Clinical and blood investigations were performed prior to the first injection, daily during the treatment period and on the day after treatment ended, and then once more, 26 days after the first injection. During the study, no significant differences were found between the two groups with respect to survival rate (treatment group: 68 per cent; control group: 71 per cent, P > 0 4, Fisher-Test) and other clinical findings. Similarly the total leukocyte count, neutrophil count and other haematologic and biochemical parameters did not differ significantly between the groups, based on differences from initial values (P > 0 05). Consequently, the use of rhG-CSF in the treatment of dogs with parvoviral enteritis cannot be recommended.
Mischke
R
R
Clinic for Small Animals, School of Veterinary Medicine, Hannover, Germany. Reinhard.Mischke@tiho-hannover.de
Barth
T
T
Wohlsein
P
P
Rohn
K
K
Nolte
I
I
D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000821:virology*; D004285:Dogs; D004311:Double-Blind Method; D004751:Enteritis / Q000188:drug therapy / Q000662:veterinary* / Q000821:virology; D004906:Erythrocyte Count / Q000662:veterinary; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count / Q000662:veterinary; D007970:Leukopenia / Q000188:drug therapy / Q000662:veterinary / Q000821:virology; D010322:Parvoviridae Infections / Q000188:drug therapy / Q000662:veterinary* / Q000821:virology; D017992:Parvovirus / Q000254:growth & development*; D011994:Recombinant Proteins / Q000627:therapeutic use; D018709:Statistics, Nonparametric
D006454:Hemoglobins; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor