Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: a risk analysis.
There is doubt that variant Creutzfeldt-Jakob disease (vCJD) resulted from bovine spongiform encephalopathy (BSE) transmission from cattle to human. What is uncertain is the total number of vCJD cases (currently about 80). In this review I covered recent data on the vCJD and BSE epidemic, the mode of BSE spreading to humans and, finally, the data on the PRNP analogue--the doppel gene (PRND).
Liberski
P P
PP
Department of Molecular Biology, Chair of Oncology, Medical Academy Lódź, Poland. ppliber@psk2.am.lodz.pl
D000293:Adolescent; D000328:Adult; D000368:Aged; D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D002417:Cattle; D002648:Child; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D004196:Disease Outbreaks; D016643:Encephalopathy, Bovine Spongiform / Q000453:epidemiology* / Q000635:transmission; D005060:Europe / Q000453:epidemiology; D005260:Female; D006041:Goats; D006801:Humans; D015994:Incidence; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008460:Meat / Q000009:adverse effects; D051379:Mice; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D009154:Mutation; D016366:Open Reading Frames / Q000235:genetics; D009928:Organ Specificity; D011044:Poland; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology; D011328:Prions / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D020033:Protein Isoforms / Q000737:chemistry; D012608:Scrapie / Q000209:etiology; D012756:Sheep; D013045:Species Specificity; D006113:United Kingdom / Q000453:epidemiology
D011328:Prions; D020033:Protein Isoforms