A comparison of the survival of shipped and locally transplanted cadaveric renal allografts.
BACKGROUND
The effect on allograft survival of the shipment of cadaveric renal allografts from one organ-procurement organization to another is uncertain.


METHODS
Using data from the Organ Procurement and Transplantation Network of the United Network for Organ Sharing, we identified 5446 pairs of cadaveric kidneys (10,892 allografts) in which one kidney was shipped and the other was transplanted locally. We compared the risk of graft failure using statistical models that accounted for confounding variables, including the degree of HLA mismatching.


RESULTS
After adjustment for the degree of HLA mismatching, shipped organs had a significantly higher rate of allograft failure than locally transplanted organs in the first year after transplantation (adjusted hazard ratio, 1.17; 95 percent confidence interval, 1.05 to 1.31; P=0.004), but not thereafter. An association between the shipment of organs with no HLA mismatches and allograft failure was not confirmed.


CONCLUSIONS
The shipment of cadaveric renal allografts increases the risk of failure of HLA-mismatched grafts during the first year after transplantation.
Mange
K C
KC
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, USA. kmange@cceb.med.upenn.edu
Cherikh
W S
WS
Maghirang
J
J
Bloom
R D
RD
D000208:Acute Disease; D002102:Cadaver; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D008297:Male; D015999:Multivariate Analysis; D009926:Organ Preservation; D016016:Proportional Hazards Models; D016019:Survival Analysis; D013997:Time Factors; D009927:Tissue and Organ Procurement / Q000379:methods*; D014184:Transplantation, Homologous; D014186:Transportation; D017211:Treatment Failure; D014481:United States