Host genetic background at CCR5 chemokine receptor and vitamin D receptor loci and human immunodeficiency virus (HIV) type 1 disease progression among HIV-seropositive injection drug users.
The effect of polymorphisms on genes encoding the CCR5 chemokine receptor and vitamin D receptor (VDR) in human immunodeficiency virus (HIV) type 1 disease progression was analyzed in a cohort of 185 HIV-seropositive injection drug users. Results confirmed a lack of association in patients with HIV disease between CCR5 wtDelta32 heterozygosity and a slow progression to AIDS and to a CD4 cell count <200 cells/microL. In contrast, a more rapid disease progression was associated with the VDR-BB genotype. A higher proportion of this genotype was found in patients with <200 CD4 cells/microL (P=.009; odds ratio [OR], 2.4; 95% confidence interval [CI], 1.3-4.7), as well as a faster progression both to AIDS (1993 CDC classification [CDC 1993]) and to a CD4 cell count <200 cells/microL. When the analysis was restricted to patients with a VDR-bb genetic background, patients with CCR5 wtDelta32 heterozygosity were overrepresented in CDC 1993 nonprogressors (P=.033; OR, 0.28; 95% CI, 0.08-0.92) and in those with >200 CD4 cells/microL (P=.062; OR, 0.26; 95% CI, 0.06-1.08). Also, patients with CCR5 wtDelta32 heterozygosity showed a slow progression both to AIDS CDC 1993 and to a CD4 cell count <200 cells/microL.
Barber
Y
Y
Departament de Ciències Mèdiques Bàsiques, University of Lleida, Spain.
Rubio
C
C
Fernández
E
E
Rubio
M
M
Fibla
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D015331:Cohort Studies; D016001:Confidence Intervals; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D006679:HIV Seropositivity / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D015497:HIV-1; D006579:Heterozygote; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D015819:Substance Abuse, Intravenous / Q000453:epidemiology / Q000503:physiopathology*
D019713:Receptors, CCR5; D018167:Receptors, Calcitriol