Palladium-Catalyzed Carbonylation and Coupling Reactions of Aryl Chlorides and Amines.
The palladium-catalyzed amidation of electron-deficient aryl chlorides proceeds readily in the presence of low CO pressures and a slight excess of an iodide salt. The rates of amidation are accelerated over those without added salt, and iodide is preferred over bromide or chloride. More electron-rich aryl chlorides were not effectively amidated, either with or without added iodide. We postulate that an intermediate anionic palladium(0) iodide complex is responsible for the enhanced reactivity.
Perry
Robert J.
RJ
Imaging Research and Advanced Development, Eastman Kodak Company, Rochester, New York 14650-1705.
Wilson
B. David
BD