title: [Osmotic opening of the hematoencephalic barrier in experiments. Review].
abstract: This article describes the mechanism of osmotic opening of the blood-brain barrier (BBB) by intracarotic injection of a hyperosmolar agent (mannitol) and how to test the open BBB by intravital dyes, especially Evans blue.
authors.affiliation: Neurochirurgická klinika 1. LF UK a UVN, subkatedra neurochirurgie IPVZ, Praha.
authors.forename: P
authors.initials: P
authors.lastname: Kozler
mesh_terms: D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology*; D001929:Brain Edema / Q000503:physiopathology; D004396:Coloring Agents; D004234:Diuretics, Osmotic / Q000494:pharmacology; D005070:Evans Blue; D006801:Humans; D006982:Hypertonic Solutions / Q000008:administration & dosage; D066298:In Vitro Techniques; D008353:Mannitol / Q000494:pharmacology; D009995:Osmosis; D010539:Permeability
chemical_list: D004396:Coloring Agents; D004234:Diuretics, Osmotic; D006982:Hypertonic Solutions; D008353:Mannitol; D005070:Evans Blue