title: Synthesis of (9R,12S)- and (9S,12S)-Cycloisodityrosine and Their N-Methyl Derivatives.
abstract: Full details of the synthesis of (9R,12S)- and (9S,12S)-cycloisodityrosine and their N-methyl derivatives are detailed based on an intramolecular nucleophilic aromatic substitution reaction for formation of the key biaryl ether with 14-membered ring macrocyclization. Their comparison with prior samples and the documentation of a facile C9 epimerization within the natural 9S series are described.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037.
authors.forename: Dale L.
authors.initials: DL
authors.lastname: Boger
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Zhou
authors.forename: Robert M.
authors.initials: RM
authors.lastname: Borzilleri
authors.forename: Seiji
authors.initials: S
authors.lastname: Nukui
authors.forename: Steven L.
authors.initials: SL
authors.lastname: Castle