title: New thermo-couple copper constantan catheter for measuring regional coronary blood flow and evaluating metabolism.
abstract: A new thermodilution catheter with a thermo-couple copper constantan and latex balloon in the tip has recently been developed. This device has two orifices. The left anterior descending (LAD) and/or left circumflex (LCX) flows were measured using a Doppler flow wire. The correlation between the LAD and GCV flow as well as between the LCX and CS-GCV flow were studied in closed chest animals. The flow distributions were evaluated by colored microspheres that were infused into the LAD and LCX. The regional lactate extraction ratio was measured by GCV and/or CS blood sampling performed either with or without balloon inflation before and during pacing in either LAD or LCX occluded animals. The correlations between the LAD and GCV flow, as well as between the LCX and CS-GCV flow were significant (r=0.96, r=0.93, n=30, p<0.001). The flow distribution by color microspheres in the GCV was 75+/-10% for the LAD, whereas in CS it was 70+/-12% for the LCX. By pacing, the lactate extraction ratio of the drained blood from the ischemic myocardium was +10+/-3% in the GCV blood, whereas it was -10+/-4% (p<0.01) in the CS blood. Thus, this new thermodilution catheter with a balloon was found to be useful for measuring regional coronary hemodynamics and also for evaluating the regional myocardial metabolism.
authors.affiliation: Department of Biomedical Engineering, National Defense College, Tokorozawa, Saitama, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kurita
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Ishizuka
authors.forename: B
authors.initials: B
authors.lastname: Takase
authors.forename: K
authors.initials: K
authors.lastname: Satomura
authors.forename: S
authors.initials: S
authors.lastname: Hara
mesh_terms: D002404:Catheterization / Q000295:instrumentation*; D003300:Copper; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000378:metabolism*; D008955:Models, Cardiovascular; D013815:Thermodilution
chemical_list: D003300:Copper