A-waves in patients with novel hereditary motor and sensory neuropathy Lom.
OBJECTIVE
To determine A-waves of a family with autosomal recessive form of demyelinatig hereditary motor and sensory neuropathy Lom (HMSNL).


METHODS
A-waves were investigated during conventional F-wave study of family members with HMSNL which had genetic testing.


RESULTS
During routine F-wave studies A-waves were observed in all tested nerves. They appeared between M-responses and F-wave. The A-waves were with low amplitude, shorter duration and constant shape and latency than F-waves. They appeared independently of F-waves. A-waves were more often recorded as multiple waves in lower and upper extremities. More than three A-waves per nerve were found mostly in ulnar and facial nerves. In 16 cases A-waves were found in the absence of F-waves.


CONCLUSIONS
It is assumed that the A-waves could be seen as additional signs of pathology because they were not observed in unaffected members of the family and in healthy subjects.
Alexandrov
A S
AS
Institute of Biophysics, Bulgarian Academy of Sciences, Sofia. alex@bio.bas.bg
Christova
L G
LG
Ishpekova
B A
BA
D000200:Action Potentials; D000293:Adolescent; D000328:Adult; D002648:Child; D004576:Electromyography; D005260:Female; D015417:Hereditary Sensory and Motor Neuropathy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009132:Muscles / Q000503:physiopathology*; D011930:Reaction Time