title: Portal hypertension secondary to Langerhans cell histiocytosis.
abstract: We report two children, aged 2 and 2 1/2 years, with multisystem Langerhans cell histiocytosis (LCH). Both were administered chemotherapy, with apparently good response. However, hepatic fibrosis and portal hypertension were detected 5 and 1 1/2 years after therapy, respectively. The first child died after a bout of hematemesis. Hepatic fibrosis can proceed despite apparently successful chemotherapy in LCH.
authors.affiliation: Division of Pediatric Hematology-Oncology, Advanced Pediatric Center, Chandigarh.
authors.forename: D
authors.initials: D
authors.lastname: Bansal
authors.forename: R K
authors.initials: RK
authors.lastname: Marwaha
authors.forename: A
authors.initials: A
authors.lastname: Trehan
authors.forename: U
authors.initials: U
authors.lastname: Poddar
authors.forename: B D
authors.initials: BD
authors.lastname: Radotra
mesh_terms: D002675:Child, Preschool; D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis / Q000209:etiology*; D008297:Male