title: Dosing time-dependent effect of trandolapril on the prevention of cardiac hypertrophy in rats with aortic banding.
abstract: Trandolapril was given to male Wistar rats with aortic banding at 10 AM or 10 PM for 6 weeks to examine the influence of dosing time on the development of left ventricular mass (LVM). Aortic banding increased the LVM compared with the sham-operated animals (P<0.01). Trandolapril (1 mg/kg) at 10 AM reduced LVM (1.74+/-0.04 [S.E.M.] mg/g) more than the dosing at 10 PM (1.92+/-0.04 mg/g, P<0.05), suggesting that trandolapril has a dosing time-dependent effect in the prevention of cardiac hypertrophy in rats with aortic banding.
authors.affiliation: Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan. ksugi@jichi.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Sugimoto
authors.forename: M
authors.initials: M
authors.lastname: Ohmori
authors.forename: A
authors.initials: A
authors.lastname: Kawaguchi
authors.forename: S
authors.initials: S
authors.lastname: Tsuruoka
authors.forename: A
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000601:surgery; D006332:Cardiomegaly / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D017379:Hypertrophy, Left Ventricular / Q000517:prevention & control; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; C052035:trandolapril