title: Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics.
abstract: Data concerning cytogenetic features of childhood ependymoma are rare. In this article, a gain of 1q was identified as the sole alteration in a primary childhood infratentorial ependymoma by comparative genomic hybridization (CGH). A recurrence of this brain tumor was studied using multiplex-fluorescence in situ hybridization (M-FISH) in addition to CGH and G-banding analysis. In accordance with the primary tumor, a gain of 1q corresponding to an isochromosome 1q was observed indicating an early event in the tumor development. Furthermore, M-FISH classified several other rearranged chromosomes including 6q and 17p that have previously been found to be involved in the development and progression of childhood ependymoma.
authors.affiliation: Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Granzow
authors.forename: S
authors.initials: S
authors.lastname: Popp
authors.forename: S
authors.initials: S
authors.lastname: Weber
authors.forename: B
authors.initials: B
authors.lastname: Schoell
authors.forename: H
authors.initials: H
authors.lastname: Holtgreve-Grez
authors.forename: L
authors.initials: L
authors.lastname: Senf
authors.forename: D
authors.initials: D
authors.lastname: Hager
authors.forename: J
authors.initials: J
authors.lastname: Boschert
authors.forename: W
authors.initials: W
authors.lastname: Scheurlen
authors.forename: A
authors.initials: A
authors.lastname: Jauch
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D004806:Ependymoma / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male