title: Determining confidence intervals when measuring genetic diversity and the discriminatory abilities of typing methods for microorganisms.
abstract: We describe here a method for determining confidence intervals for a commonly used index of diversity. This approach facilitates the comparison of the genetic population structure of microorganisms isolated from different environments and improves the objective assessment of the discriminatory power of typing techniques.
authors.affiliation: Division of Microbiology and Infectious Diseases, University Hospital Nottingham, University of Nottingham, Nottingham NG7 2UH, United Kingdom. Hajo.Grundmann@Nottingham.ac.uk
authors.forename: H
authors.initials: H
authors.lastname: Grundmann
authors.forename: S
authors.initials: S
authors.lastname: Hori
authors.forename: G
authors.initials: G
authors.lastname: Tanner
mesh_terms: D015373:Bacterial Typing Techniques; D002353:Carrier State / Q000382:microbiology*; D016001:Confidence Intervals; D015252:Deoxyribonucleases, Type II Site-Specific; D016521:Electrophoresis, Gel, Pulsed-Field; D014644:Genetic Variation; D006760:Hospitalization; D006801:Humans; D019105:Random Amplified Polymorphic DNA Technique; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification* / Q000235:genetics*
chemical_list: C025651:CCCGGG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific