[Hemoglobin-induced lipid peroxidation in anemia].
Changes were studied in processes of peroxide oxidation of lipid (LPO), such as neutral lipids and phospholipids, as related to the levels of hemoglobin (Hb) and its derivatives, methemoglobin (Met-Hb) and carboxyhemoglobin (CO-Hb) in erythrocytes and blood plasma of 33 patients with iron-deficiency anemia (IDA). It has been found out that in IDA, decline in the concentration of Hb correlates with augmentation of the content of Met-Hb (r = -0.670, P = 0.038). Increase in the level of Met-Hb is accompanied by an accumulation in erythrocytes of Schiff bases as the final products of phospholipids peroxidation (r = 0.586, P = 0.004), CO-Hb-substrates of LPO (r = 0.425, P = 0.049), primary (r = 0.453, P = 0.04) and secondary (r = 0.438, P = 0.048) molecular products of peroxide oxidation of neutral lipids. A mechanism is discussed of the Hb derivatives Met-Hb and CO-Hb concurrence in the activation of LPO in IDA.
Moshynska
O V
OV
Tretiak
N N
NN
Anoshina
M Y
MY
Yagovdick
M V
MV
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000378:metabolism*; D002263:Carboxyhemoglobin / Q000032:analysis; D015331:Cohort Studies; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008706:Methemoglobin / Q000032:analysis; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood
D006454:Hemoglobins; D008055:Lipids; D010743:Phospholipids; D008706:Methemoglobin; D002263:Carboxyhemoglobin