title: Shortened duration of untreated first episode of psychosis: changes in patient characteristics at treatment.
abstract: OBJECTIVE
  This study examined whether duration of untreated psychosis can be shortened in patients with first episodes of DSM-IV schizophrenia spectrum disorders and whether shorted duration alters patient appearance at treatment.
  
  
  METHODS
  Two study groups were ascertained in the same Norwegian health care sector: one from 1993-1994 with usual detection methods and one from 1997-1998 with early detection strategies that included education about psychosis.
  
  
  RESULTS
  Patients with early detection had a shorter median duration of untreated psychosis by 21.5 weeks than patients with usual detection. The number with psychosis was greater in the early detection group; the number with schizophrenia was less. Early detection patients had more substance abuse and were younger, better adjusted premorbidly, and less ill.
  
  
  CONCLUSIONS
  Early detection can shorten duration of untreated psychosis and help more patients when they are less severely ill. Given the devastation of psychosis, this is a significant treatment advance.
authors.affiliation: Department of Psychiatry, Yale University, New Haven, Conn., USA. tklarsen@online.no
authors.forename: T K
authors.initials: TK
authors.lastname: Larsen
authors.forename: T H
authors.initials: TH
authors.lastname: McGlashan
authors.forename: J O
authors.initials: JO
authors.lastname: Johannessen
authors.forename: S
authors.initials: S
authors.lastname: Friis
authors.forename: C
authors.initials: C
authors.lastname: Guldberg
authors.forename: U
authors.initials: U
authors.lastname: Haahr
authors.forename: M
authors.initials: M
authors.lastname: Horneland
authors.forename: I
authors.initials: I
authors.lastname: Melle
authors.forename: L C
authors.initials: LC
authors.lastname: Moe
authors.forename: S
authors.initials: S
authors.lastname: Opjordsmoen
authors.forename: E
authors.initials: E
authors.lastname: Simonsen
authors.forename: P
authors.initials: P
authors.lastname: Vaglum
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index; D012917:Social Adjustment; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents