title: Regional myocardial systolic function during acute myocardial ischemia assessed by strain Doppler echocardiography.
abstract: OBJECTIVE
  We sought to evaluate if echocardiographic strain measurements could detect acute myocardial ischemia, and to compare this new method with myocardial velocity measurements and wall motion score index.
  
  
  BACKGROUND
  Tissue Doppler echocardiography (TDE) is a promising method for assessing regional myocardial function. However, myocardial velocities measured by tissue Doppler echocardiography (TDE) vary throughout the left ventricle (LV) because of tethering effects from adjacent tissue. Strain Doppler echocardiography (SDE) is a new tool for measuring regional myocardial deformation excluding the effect of adjacent myocardial tissue.
  
  
  METHODS
  Seventeen patients undergoing angioplasty of the left anterior descending coronary artery (LAD) were studied. Left ventricular longitudinal wall motion was assessed by TDE and SDE from the apical four-chamber view before, during and after angioplasty from multiple myocardial segments simultaneously.
  
  
  RESULTS
  Systolic strain values were uniformly distributed in the different nonischemic LV segments, whereas systolic velocities decreased from basis to apex. During LAD occlusion, strain measurement showed expansion in the apical septal segment in 16 of 17 patients (7.5 +/- 6.5% vs. -17.7 +/- 7.2%, p < 0.001) and reduced compression in the mid-septal segment (p < 0.05) compared with baseline. Segments not supplied by LAD remained unchanged. Tissue Doppler echocardiography showed reduced velocities in all septal segments (p < 0.05) during angioplasty even though LAD does not supply the basal septal segment. Negative systolic velocities were present in 11 of 17 patients. Wall motion score index increased during ischemia (1.3 +/- 0.4, p < 0.05).
  
  
  CONCLUSIONS
  The new SDE approach might be a more accurate marker than TDE for detecting systolic regional myocardial dysfunction induced by LAD occlusion.
authors.affiliation: Department of Cardiology, National Hospital, University of Oslo, Norway. thor.edvardsen@klinmed.uio.no
authors.forename: T
authors.initials: T
authors.lastname: Edvardsen
authors.forename: H
authors.initials: H
authors.lastname: Skulstad
authors.forename: S
authors.initials: S
authors.lastname: Aakhus
authors.forename: S
authors.initials: S
authors.lastname: Urheim
authors.forename: H
authors.initials: H
authors.lastname: Ihlen
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D000800:Angioplasty, Balloon; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D013599:Systole / Q000502:physiology*