title: Influence of canal paresis and compensation on gain and time constant of nystagmus slow-phase velocity to yaw-axis rotation.
abstract: In order to assess the influence of canal paresis and compensation on the yaw-axis rotatory chair test parameters gain and time constant, a study was conducted in 435 patients diagnosed with unilateral peripheral vestibulopathy. Patients were grouped according to the amount of canal paresis found in the caloric test and by the result of a bedside examination of the vestibulo-ocular reflex (VOR). The time constant of the VOR diminishes as canal paresis increases and, when using a high-velocity sinusoidal test, there is a similar reduction in gain. Mean time constant was reduced when rotations were to the side of the lesion (ipsilesional) and to the normal (contralesional) and differences between both rotations were found for 21-80%, canal paresis. Ipsilesional gain was significantly less than contralesional gain, which had a normal result independent of the amount of canal paresis; differences between them were significant when canal paresis was > 41%. Spontaneous nystagmus significantly influenced the appearance of asymmetries in gain and time constant in the tests performed while, with high-velocity sinusoidal rotation, gain was found to be significantly different for ipsilesional and contralesional rotations in non-acute symptomatic patients.
authors.affiliation: Department of Otorhinolaryngology, University Hospital and Medical School, University of Navarra, Pamplona, Spain. nperezfer@unav.es
authors.forename: N
authors.initials: N
authors.lastname: Perez
authors.forename: E
authors.initials: E
authors.lastname: Martin
authors.forename: M D
authors.initials: MD
authors.lastname: Romero
authors.forename: R
authors.initials: R
authors.lastname: Garcia-Tapia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002150:Caloric Tests; D002648:Child; D007758:Ear, Inner / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D010291:Paresis / Q000503:physiopathology*; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D012438:Saccades / Q000502:physiology; D013997:Time Factors; D014717:Vertigo / Q000150:complications / Q000209:etiology