N-terminal sequences of small ion channels in rectal glands of sharks: a biochemical hallmark for classification and phylogeny?
The rectal gland of sharks contains a 13.2-kDa microsomal protein that in primary structure resembles to a variable extent the mammalian Cl- channel phospholemman. It appears to reside in basolateral as well as in apical membranes. The large variation in primary structure among different orders and families of sharks could make the protein a hallmark for classification.
Schuurmans Stekhoven
F M
FM
Department of Animal Physiology, University of Nijmegen, Toernooiveld 1, Nijmegen, 6525 ED, The Netherlands.
Flik
G
G
Wendelaar Bonga
S E
SE
D000818:Animals; D015415:Biomarkers / Q000737:chemistry; D007473:Ion Channels / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D008861:Microsomes / Q000378:metabolism; D008970:Molecular Weight; D010750:Phosphoproteins / Q000378:metabolism / Q000502:physiology; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D012491:Salt Gland / Q000378:metabolism*; D020539:Sequence Analysis, Protein; D012754:Sharks / Q000378:metabolism*
D015415:Biomarkers; D007473:Ion Channels; D008565:Membrane Proteins; D010750:Phosphoproteins; C069141:phospholemman