title: Highly Chemo- and Regioselective Thiocarbonylation of Conjugated Enynes with Thiols and Carbon Monoxide Catalyzed by Palladium Complexes: An Efficient and Atom-Economical Access to 2-(Phenylthiocarbonyl)-1,3-dienes.
abstract: The reaction of 1, 3-conjugated enynes bearing a terminal triple bond with thiols and carbon monoxide in the presence of catalytic quantities of Pd(OAc)(2) (3 mol %) and 1,3-bis(diphenylphosphino)propane (6 mol %) in THF at 110 degrees C gave 2-(phenylthiocarbonyl)-1,3-dienes in moderate to good yields. The thiocarbonylation takes place with high chemo- and regioselectivity, with the attack by the phenylthiocarbonyl group occurring exclusively at carbon-2 of the 1,3-conjugated enyne.
authors.affiliation: Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vasapollo
authors.forename: Howard
authors.initials: H
authors.lastname: Alper