Room-Temperature Palladium-Catalyzed Amination of Aryl Bromides and Chlorides and Extended Scope of Aromatic C-N Bond Formation with a Commercial Ligand.
The reactions of aryl bromides with amines occurs at room temperature when using Pd(0) and P(t-Bu)(3) in a 1:1 ratio, and the reactions of aryl chlorides occur at room temperature or 70 degrees C. The arylation of indoles and the new arylation of carbamates also occur when using P(t-Bu)(3) as ligand.
Hartwig
John F.
JF
Department of Chemistry, Yale University P.O. Box 208107, New Haven, Connecticut 06520-8107.
Kawatsura
Motoi
M
Hauck
Sheila I.
SI
Shaughnessy
Kevin H.
KH
Alcazar-Roman
Luis M.
LM