title: Synthesis of some 2-methylthiouracil nucleosides and its 5-halo analogues of 2-acetamido-2-deoxy-D-glucose.
abstract: This paper describes the regiospecific synthesis of 5-halo-2-methylthiouracil nucleosides by direct glycosylation followed by halogenation by an electrophilic halogen reagent and sodium azide under mild conditions. The compounds were suggested to be effective as antiviral agents.
authors.affiliation: Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Abdel-Rahman
mesh_terms: D000117:Acetylglucosamine / Q000737:chemistry*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D004261:DNA Replication / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008779:Methylthiouracil / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D007202:Indicators and Reagents; D009705:Nucleosides; D008779:Methylthiouracil; D000117:Acetylglucosamine