Chemokines in autoimmune disease.
Growing evidence indicates that structural cells play a crucial role in the chronic inflammation of autoimmunity by their recruitment of chemokine-dependent cells. Members of the two functional classes of chemokines, inflammatory and homeostatic, seem to be involved in lymphocyte recruitment and survival, and in establishing ectopic lymphoid structures in the target organs of autoimmune diseases. Results from animal models suggest that chemokines are reasonable therapeutic targets in autoimmunity.
Godessart
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Department of Pharmacology, Almirall Prodesfarma Research Center, Cardener 68-74, 08028, Barcelona, Spain. Ngodessa@almiralprodesfarma.com
Kunkel
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SL
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology
D018925:Chemokines