ImmunoCyt a useful method in the follow-up protocol for patients with urinary bladder carcinoma.
OBJECTIVE
To evaluate the ImmunoCyt test--a urine-bound test for the detection of malignant transitional cells.


METHODS
ImmunoCyt was compared with the standard investigation at our hospital for bladder cancer--cystoscopy, cytological examination of bladder wash material and, if necessary, a histological examination. A voided urine sample was collected before cystoscopy. We investigated 121 patients; seven specimens could not be evaluated.


RESULTS
Thirty-one of the 114 patients had a histologically proven urinary bladder carcinoma. All 31 cases were positive in the ImmunoCyt test. Twenty-six of the 83 negative cases were ImmunoCyt positive. The sensitivity was 100% and the specificity was 68.7%.


CONCLUSIONS
ImmunoCyt is easily applicable in a small laboratory and has high sensitivity and acceptable specificity.
Olsson
H
H
Department of Clinical Pathology, Borås Central Hospital, Sweden.
Zackrisson
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000652:urine; D003558:Cystoscopy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000032:analysis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000652:urine; D014556:Urine / Q000166:cytology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D009077:Mucins