title: [Epidemiology of soft tissue sarcomas in adults].
abstract: Soft tissue sarcoma accounts for a approximately 1% of all cancers. Excluding Kaposi sarcoma, the incidence of soft tissue sarcoma has remained stable in Europe (3-4/100,000). ENDOGENOUS FACTORS: Endogenous factors are related to rare genetic syndromes (Li-Fraumeni syndrome, neurofibromatosis, Werner syndrome, bilateral retinoblastom). EXOGENOUS FACTORS: Exogenous factors associated with soft tissue sarcoma are essentially iatrogenic: radiation therapy (prevalence of radiation-induced sarcoma: 0.17-0.21%) and chronically edematous arms after radical mastectomy for breast cancer (Stewart-Treves syndrome). Many studies suggest that environmental or occupational exposure to chlorophenol, phenoxy-herbicides or dioxin increase the risk of soft tissue sarcoma. FURTHER RESEARCH: Little is known about the epidemiology of soft tissue sarcoma. Case-control studies are needed.
authors.affiliation: Département de Cancérologie Générale, CHRU de Lille, CERESTE, Université de Lille II. n-penel@o-lambret.fr
authors.forename: N
authors.initials: N
authors.lastname: Penel
authors.forename: C
authors.initials: C
authors.lastname: Nisse
authors.forename: S
authors.initials: S
authors.lastname: Feddal
authors.forename: E
authors.initials: E
authors.lastname: Lartigau
mesh_terms: D000328:Adult; D000368:Aged; D001132:Arm / Q000473:pathology; D001943:Breast Neoplasms / Q000601:surgery; D004487:Edema / Q000150:complications / Q000209:etiology; D004781:Environmental Exposure; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008408:Mastectomy / Q000009:adverse effects; D008875:Middle Aged; D016273:Occupational Exposure; D012307:Risk Factors; D012509:Sarcoma / Q000453:epidemiology* / Q000209:etiology*; D012983:Soft Tissue Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D015262:Xenobiotics / Q000009:adverse effects
chemical_list: D015262:Xenobiotics