title: Total Synthesis of Bistratamide D.
abstract: The total synthesis of the macrocyclic hexapeptide bistratamide D is reported. The synthetic strategy involved assembly of enantiomerically pure oxazole, thiazole, and oxazoline segments derived from amino acids. Macrocyclization of the hexapeptidic aminooxazoline-oxazole-thiazole carboxylic acid fragment was accomplished by activation with O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU).
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523.
authors.forename: Susan V.
authors.initials: SV
authors.lastname: Downing
authors.forename: Enrique
authors.initials: E
authors.lastname: Aguilar
authors.forename: A. I.
authors.initials: AI
authors.lastname: Meyers