title: Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats.
abstract: The hypoglycemic effects of water and butanolic extracts prepared from leaves of Cecropia obtusifolia (Cecropiaceae) were examined in streptozotocin induced diabetic rats. A single oral administration of a water extract at doses of 90 and 150 mg/kg and of a butanol extract at doses of 9 and 15 mg/kg significantly (P<0.05) lowered the plasma glucose levels in diabetic rats after 3 h administration. Glibenclamide was used as reference and showed similar hypoglycemic effect to the tested extracts at a dose of 3 mg/kg. The flavone, isoorientin and 3-caffeoylquinic acid (chlorogenic acid), were isolated as the important constituents of the plant and were identified as the main constituents in both extracts, too.
authors.affiliation: Departamento de Biología Celular, Fac. de Ciencias, Universidad Nacional Autónoma de México (UNAM), Apartado postal 70-359, Coyoacan, 04511, Mexico DF, Mexico. aac@hp.fciencias.unam.mx
authors.forename: A
authors.initials: A
authors.lastname: Andrade-Cetto
authors.forename: H
authors.initials: H
authors.lastname: Wiedenfeld
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D008519:Medicine, Traditional; D008800:Mexico; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts