Ethnic variation in genotype frequencies of a p53 intron 7 polymorphism.
Using a PCR-restriction enzyme-based method we found large ethnic variations when a C-->T polymorphism in the human p53 gene at position 14181 in intron 7 was studied in Finnish, Polish, Hungarian, Italian, Japanese, Indian and Chinese populations. The largest variations were found between Caucasian and Asian, genotype frequencies varied from C 0.95 and T 0.05 in the Finnish population to C 0.67 and T 0.33 in the Chinese population, the relative risk (RR) for T being 6.5 (95% CI 3.4-12.3, P < 0.001). Variations were also found between Finnish and Italian and between Italian and Chinese (RR for T 2.4, 95% CI 1.2-4.9 and 2.7, 95% CI 1.7-4.2, respectively).
Berggren
P
P
Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden. petra.berggren@cnt.ki.se
Kumar
R
R
Steineck
G
G
Ichiba
M
M
Hemminki
K
K
D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D004247:DNA / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005006:Ethnicity / Q000235:genetics* / Q000706:statistics & numerical data; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D016158:Genes, p53 / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007194:India / Q000453:epidemiology; D007438:Introns / Q000235:genetics*; D007558:Italy / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics
D004273:DNA, Neoplasm; D004247:DNA