Manoyl oxide alpha-arabinopyranoside and grindelic acid diterpenoids from Grindelia integrifolia.
Two new manoyl oxide-alpha-arabinopyranoside diterpenoids, 15-hydroxy-13-epi-manoyl oxide-14-O-alpha-L-arabinopyranoside (tarapacol-14-O-alpha-L-arabinopyranoside) (1) and 15-acetoxy-13-epi-manoyl oxide-14-O-alpha-L-arabinopyranoside (tarapacol-15-acetate-14-O-alpha-L-arabinopyranoside) (2), as well as a new grindelic acid derivative, 19-hydroxygrindelic acid (3), together with five known diterpenoids (tarapacol, tarapacanol A, grindelic acid, methyl grindeloate, 3beta-hydroxygrindelic acid, 4) were isolated from the aerial parts of Grindelia integrifolia. The structures of 1-3 were elucidated by spectral data analysis.
Ahmed
A A
AA
Department of Chemistry, Faculty of Science, El-Minia University, El-Minia 61519, Egypt. abdellaahmed@yahoo.com
Mahmoud
A A
AA
Ahmed
U M
UM
El-Bassuony
A A
AA
Abd El-Razk
M H
MH
Pare
P W
PW
Karchesy
J
J
D019659:Asteraceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
C440970:15-acetoxy-13-epi-manoyl oxide-14-O-alpha-L-arabinopyranoside; C440969:15-hydroxy-13-epi-manoyl oxide-14-O-arabinopyranoside; C440971:19-hydroxygrindelic acid; C440972:3-hydroxygrindelic acid; D004224:Diterpenes; D006027:Glycosides