[Comparative study of immunomodulating effects of natural experimental preparations on phagocytosis of Yersinia pseudotuberculosis].
To correct defects of the body's phagocytic system, the authors used experimental agents, such as vital activity products of plant cells, which were obtained by biotechnology. These included arabinogalactan, syringin, K-212, and DFEGP. The study agents activate the oxidative metabolism of macrophages, the production of active forms of oxygen, and thus enhance its bactericidal effect against Yersinia pseudotuberculosis. Syringin and arabinogalactan produce a more pronounced stimulating macrophageal effect in Yersinia pseudotuberculosis phagocytosis than do K-212 and DFEGP. The findings indicate that further studies of the effects of these tested and other agents on humoral and cellular immunity are required.
Dubrovina
V I
VI
Golubinskiĭ
E P
EP
Borsuk
G I
GI
Medvedeva
S A
SA
Aleksandrova
G P
GP
Konovalova
Zh A
ZhA
Semenov
A A
AA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005685:Galactans / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D010587:Phagocytosis / Q000187:drug effects*; D010666:Phenylpropionates / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology; D015011:Yersinia pseudotuberculosis / Q000502:physiology*
D000276:Adjuvants, Immunologic; D005685:Galactans; D005960:Glucosides; D010666:Phenylpropionates; D011134:Polysaccharides; C028305:syringin; C005653:arabinogalactan