title: Determination of octanol-water partition coefficients of pesticides by microemulsion electrokinetic chromatography.
abstract: Microemulsion electrokinetic chromatography (MEEKC) was evaluated as a screening tool for the indirect measurement of octanol-water partition coefficients (log Po/w) of pesticide compounds. Over 80 pesticide compounds representing a variety of structural characteristics were studied, and good correlation of log Po/w with the logarithm of the retention factor was found. The microemulsion system studied allowed the separation of compounds in the log Po/w range of -1 to 7. In addition, a smaller set of simple organic molecules that vary in structural features was evaluated and compared to the pesticide log Po/w calibration. The pesticide and simple organic molecule log Po/w calibration lines were statistically similar. This suggests that a universal set of standard compounds may be employed for the log Po/w calibration to provide measurements for a variety of compounds with good accuracy.
authors.affiliation: Department of Chemistry, Villanova University, PA 19085, USA. wklotz@rohmhaas.com
authors.forename: W L
authors.initials: WL
authors.lastname: Klotz
authors.forename: M R
authors.initials: MR
authors.lastname: Schure
authors.forename: J P
authors.initials: JP
authors.lastname: Foley
mesh_terms: D002138:Calibration; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D004655:Emulsions; D000442:Octanols / Q000737:chemistry; D010575:Pesticides / Q000032:analysis*; D014867:Water / Q000737:chemistry
chemical_list: D004655:Emulsions; D000442:Octanols; D010575:Pesticides; D014867:Water