Effects of human T-lymphotropic virus type II on human immunodeficiency virus type 1 phenotypic evolution.
Phenotypic change and broader coreceptor usage by HIV-1 have been associated with disease progression. HIV-1 coreceptor usage by primary isolates obtained from HIV-1-infected and HIV-1/HTLV-II-coinfected individuals was determined. HIV-1 was isolated from 15 of 20 HIV-1-infected and 17 of 24 HIV-1/HTLV-II-coinfected individuals. None of the isolates from either the HIV-1-infected or the coinfected group infected CCR5delta32 PBMCs, suggesting that they all were R5-tropic. Further, both spontaneous and PHA-stimulated production of MIP-1beta and RANTES were similar in HIV-1-infected and coinfected individuals. These data indicate that coinfection with HTLV-II has no effect on HIV-1 coreceptor usage or ex vivo beta-chemokine production.
Guenthner
P C
PC
HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. pcg1@cdc.gov
Hershow
R C
RC
Lal
R B
RB
Dezzutti
C S
CS
D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D019742:Chemokines, CC / Q000378:metabolism; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000502:physiology*; D015491:HTLV-II Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015367:Human T-lymphotropic virus 2 / Q000502:physiology*; D006801:Humans; D010641:Phenotype; D019713:Receptors, CCR5 / Q000378:metabolism
D019742:Chemokines, CC; D019713:Receptors, CCR5