Effects of post-natal serotonin levels on craniofacial complex.
Although the role of serotonin (5-hydroxytryptamine or 5-HT) in pre-natal craniofacial growth and development has been studied, no research has been done on the effects of serotonin on post-natal craniofacial growth and development. The following experimental question was tested: What effect does increasing in vivo serotonin levels adjacent to trigeminal motoneurons have on post-natal craniofacial structures in young, actively growing rats? Forty male Sprague-Dawley rats were divided into 4 experimental groups (10% serotonin microspheres, 15% serotonin microspheres, blank microspheres, sham surgeries) and underwent stereotactic neurosurgery at post-natal day 35; 5 rats of each group were killed at 14 and 21 post-surgical days for data collection. Statistical analyses by mixed-model, 4 x 2 repeated-measures ANOVA, and post hoc Fisher LSD tests revealed significant (P < or = 0.05, 0.01) differences between groups and sides for muscle weight, cranial dimension, and TMJ dimension data. Data described here indicate that significant alterations of post-natal craniofacial structures can be caused by altered in vivo levels of serotonin adjacent to trigeminal motoneurons.
Byrd
K E
KE
Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis 46202-5120, USA. kbyrd@iupui.edu
Sheskin
T A
TA
D000704:Analysis of Variance; D000818:Animals; D002508:Cephalometry; D005147:Facial Bones / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development; D005152:Facial Muscles / Q000187:drug effects / Q000254:growth & development; D008297:Male; D008406:Masseter Muscle / Q000033:anatomy & histology / Q000187:drug effects / Q000254:growth & development; D008863:Microspheres; D009046:Motor Neurons / Q000187:drug effects; D009334:Neck Muscles / Q000033:anatomy & histology / Q000187:drug effects / Q000254:growth & development; D018377:Neurotransmitter Agents / Q000008:administration & dosage / Q000494:pharmacology*; D009929:Organ Size; D011149:Pons / Q000187:drug effects; D011626:Pterygoid Muscles / Q000033:anatomy & histology / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D017207:Rats, Sprague-Dawley; D012154:Reticular Formation / Q000187:drug effects; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D012886:Skull / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development; D013223:Statistics as Topic; D013238:Stereotaxic Techniques; D013703:Temporal Muscle / Q000033:anatomy & histology / Q000187:drug effects / Q000254:growth & development; D013704:Temporomandibular Joint / Q000033:anatomy & histology / Q000187:drug effects / Q000254:growth & development; D014278:Trigeminal Nuclei / Q000187:drug effects
D018377:Neurotransmitter Agents; D012701:Serotonin