Spontaneous pulmonary neoplasms in cynomolgus monkeys (Macaca fascicularis)--a report of two cases.
The first lung tumour-bearing animal was a 7 years and 3 months old cynomolgus monkey. Microscopic examination revealed a neoplastic mass under the pleura that consisted of squamous islands with little keratinization, multifocal mineralization of the keratin, inflammatory cell and foreign body-type giant cell infiltration. It was classified as pulmonary squamous cell carcinoma. In a second cynomolgus monkey (2 years and 10 months old) a lung mass was observed at necropsy. Microscopically the tumour consisted of numerous islands of cartilage with glandular structures lined by a cuboidal epithelium between them. The neoplasm was classified as cartilaginous hamartoma.
Kaspareit
J
J
Covance Laboratories, Münster, Germany. joachim.kaspareit@covance.com
Friderichs-Gromoll
S
S
Buse
E
E
Korte
R
R
Vogel
F
F
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary*; D002812:Chondroma / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D006222:Hamartoma / Q000473:pathology / Q000662:veterinary*; D008175:Lung Neoplasms / Q000473:pathology / Q000662:veterinary*; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000473:pathology*