Hypothalamic regulation of sleep.
The recent discovery linking narcolepsy, a sleep disorder characterized by very short REM sleep latency, with a neuropeptide that regulates feeding and energy metabolism, provides a way to understand how several behaviors may be disrupted as a result of a defect in this peptide. In this chapter we review the evidence linking hypocretin and sleep, including our own studies, and propose that a defect in the lateral hypothalamus that also involves the hypocretin neurons is likely to produce a disturbance in sleep, mood, appetite, and rhythms.
Salin-Pascual
R
R
West Roxbury VA Medical Center and Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA.
Gerashchenko
D
D
Greco
M
M
Blanco-Centurion
C
C
Shiromani
P J
PJ
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D003866:Depressive Disorder / Q000503:physiopathology / Q000523:psychology; D001068:Feeding and Eating Disorders / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D009290:Narcolepsy / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D009479:Neuropeptides / Q000502:physiology; D000068797:Orexins; D011301:Preoptic Area / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology / Q000523:psychology; D014851:Wakefulness / Q000502:physiology
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins