Transcriptional silencing: replication redux.
Recent studies indicate that, contrary to long-held belief, DNA replication does not have a direct role in transcriptional silencing, but progression through S phase of the cell cycle is nevertheless required for the establishment of silent chromatin.
Shore
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Department of Molecular Biology, Sciences II, University of Geneva, 30 quai Ernest-Ansermet, CH-1211, 4, Geneva, Switzerland.
D002453:Cell Cycle / Q000502:physiology; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication / Q000235:genetics / Q000502:physiology*; D020868:Gene Silencing / Q000502:physiology*; D016196:S Phase / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000166:cytology; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*
D002843:Chromatin