title: Flow-mediated vasodilation of the femoral and brachial artery induced by exercise in healthy nonsmoking and smoking men.
abstract: OBJECTIVE
  We sought to analyze diameter changes of conduit arteries in response to whole-body exercise and hypothesized that this response might be endothelium-dependent and, therefore, impaired in smokers.
  
  
  BACKGROUND
  Hyperemia and coincident vasodilation are pivotal mechanisms for meeting the increased metabolic demands of active muscle tissue during physical exercise, but studies in humans are sparse.
  
  
  METHODS
  We studied diameter and blood flow of the femoral and brachial arteries in response to a submaximal bicycle exercise test in 10 nonsmoking and 8 smoking healthy male subjects. During an exercise period of 40 min the investigated conduit arteries were periodically scanned in longitudinal sections by high-resolution ultrasound. In the same subjects flow-mediated dilation (FMD) of the brachial artery was recorded by inducing an ischemia through a forearm-occluding cuff.
  
  
  RESULTS
  In response to exercise the diameter of the femoral artery significantly increased in both nonsmokers and smokers, with a diminished response in smokers (9.2 +/- 1.9% vs. 4.8 +/- 1.6%, p < 0.001). Flow-mediated dilation of the brachial artery induced by forearm occlusion was also reduced in smoking subjects, revealing a strong correlation between these different methods of FMD (exercise vs. forearm ischemia) (r = 0.88, p < 0.001). In contrast, blood flow increase of the femoral artery was similar in nonsmoking and smoking subjects (392 +/- 77% vs. 382 +/- 109%, p = NS).
  
  
  CONCLUSIONS
  Conduit arteries react with a flow-mediated dilation in response to whole-body exercise. The impairment of this vasodilation observed in smokers was strongly related to a decrease of endothelium-dependent dilation induced by forearm ischemia, indicating that endothelial dysfunction represents the underlying mechanism.
authors.affiliation: Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria. hannes.gaenzer@uibk.ac.at
authors.forename: H
authors.initials: H
authors.lastname: Gaenzer
authors.forename: G
authors.initials: G
authors.lastname: Neumayr
authors.forename: P
authors.initials: P
authors.lastname: Marschang
authors.forename: W
authors.initials: W
authors.lastname: Sturm
authors.forename: R
authors.initials: R
authors.lastname: Kirchmair
authors.forename: J R
authors.initials: JR
authors.lastname: Patsch
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000503:physiopathology; D015444:Exercise; D005080:Exercise Test; D005263:Femoral Artery / Q000503:physiopathology* / Q000601:surgery; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects* / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors; D014463:Ultrasonography; D014664:Vasodilation
chemical_list: D008055:Lipids