title: Syntheses of analogues of the insect neuropeptide proctolin containing an oxazole ring as an amide bond replacement.
abstract: [structure: see text]. Three oxazole analogues of the insect neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) have been prepared, containing a single oxazole between Tyr and Pro and between Pro and Thr, respectively. A compound containing an oxazole moiety between Tyr and Pro and between Pro and Thr has also been prepared. All compounds have been tested for myotropic activity.
authors.affiliation: Bayer AG, Central Research, 51368 Leverkusen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Plant
authors.forename: F
authors.initials: F
authors.lastname: Stieber
authors.forename: J
authors.initials: J
authors.lastname: Scherkenbeck
authors.forename: P
authors.initials: P
authors.lastname: Lösel
authors.forename: H
authors.initials: H
authors.lastname: Dyker
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D004064:Digestive System / Q000187:drug effects; D006110:Grasshoppers / Q000737:chemistry* / Q000502:physiology; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009119:Muscle Contraction / Q000187:drug effects; D009479:Neuropeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010080:Oxazoles / Q000138:chemical synthesis*; D010084:Oxidation-Reduction
chemical_list: D000577:Amides; D007202:Indicators and Reagents; D009479:Neuropeptides; D009842:Oligopeptides; D010080:Oxazoles; C011536:proctolin