title: Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation.
abstract: The use of herbal medicine has become increasingly popular in the United States. Hypericum perforatum (St. John's wort) is an herbal extract that is used widely as a folk remedy for depression. In this case report, we describe a kidney transplant recipient who developed marked reduction of cyclosporine therapeutic activity after the self-initiation of St. John's wort. Postulated mechanisms for the ability of this herbal extract to interact with pharmaceutical medications are presented, and the existing literature is reviewed.
authors.affiliation: Division of Nephrology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA.
authors.forename: C
authors.initials: C
authors.lastname: Moschella
authors.forename: B L
authors.initials: BL
authors.lastname: Jaber
mesh_terms: D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000097:blood* / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D020902:Hypericum / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000097:blood* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D012196:Review Literature as Topic
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine