title: Influence of hypotensive and normotensive anesthesia on platelet aggregability and hemostatic markers in orthognathic surgery.
abstract: This prospective randomized study investigated the influence of normotensive and hypotensive general anesthesia on platelet aggregability, intraoperative blood loss and parameters of plasmatic coagulation during extensive orthognathic surgery. A total of 30 patients were randomly allocated for either normotensive anesthesia maintained by continuous infusion of propofol and remifentanil (NORMO, n=10) or hypotensive anesthesia, whereby hypotension was induced by increasing the infusion rate of remifentanil (HYPO-R, n=10) or by administration of nitroglycerin (HYPO-N, n=10). Whole blood platelet aggregability was significantly reduced during hypotension compared to normotensive anesthesia (P<.01, HYPO-N and HYPO-R vs. NORMO). Mean arterial blood pressure during hypotension correlated well with adenosinediphosphate- (R=.712, P<.001) and collagen-induced platelet aggregability (R=.685, P<.001). Within hypotensive study groups, postoperative fibrinogen levels were significantly different, whereas intraoperative platelet aggregability, postoperative platelet count, prothrombin time, activated partial thromboplastin time and antithrombin levels were not different. Normotensive anesthesia, however, caused significant decreases in platelet count (-29%), prothrombin time (-24%), fibrinogen (-41%) and antithrombin (-28%) and a significant prolongation in activated partial thromboplastin time (+21%) and thrombin time (+18%). There was a trend to reduced intraoperative blood loss in hypotensive study groups; however, differences were not significant. In conclusion, induced hypotension--independent of substances used for induction of hypotension--reduces intraoperative platelet aggregability, subsequently protecting the coagulation system against subclinical consumption coagulopathy. Induced hypotension-caused platelet dysfunction does not lead to an increased intraoperative blood loss, but quite on the contrary shows a trend to reduced intraoperative blood loss, possibly by preventing platelet-induced subclinical consumption coagulopathy.
authors.affiliation: Department of Anesthesia and General Intensive Care, University of Vienna, Waehringer Guertel 18-20, Vienna A-1090, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Felfernig-Boehm
authors.forename: A
authors.initials: A
authors.lastname: Salat
authors.forename: C
authors.initials: C
authors.lastname: Kinstner
authors.forename: T
authors.initials: T
authors.lastname: Fleck
authors.forename: M
authors.initials: M
authors.lastname: Felfernig
authors.forename: O
authors.initials: O
authors.lastname: Kimberger
authors.forename: H
authors.initials: H
authors.lastname: Andel
authors.forename: M R
authors.initials: MR
authors.lastname: Mueller
mesh_terms: D000328:Adult; D000758:Anesthesia / Q000379:methods* / Q000592:standards; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood; D016063:Blood Loss, Surgical / Q000517:prevention & control; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology; D019647:Oral Surgical Procedures / Q000379:methods; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology; D000077208:Remifentanil
chemical_list: D018686:Anesthetics, Intravenous; D015415:Biomarkers; D010880:Piperidines; D005996:Nitroglycerin; D000077208:Remifentanil; D015742:Propofol