title: Decreased sensory cortical excitability after 1 Hz rTMS over the ipsilateral primary motor cortex.
abstract: OBJECTIVE
  To study changes in the excitability of the sensory cortex by repetitive transcranial magnetic stimulation (rTMS) in humans.
  
  
  METHODS
  Somatosensory evoked potentials (SEPs) and antidromic sensory nerve action potentials (SNAPs) were elicited by right median nerve stimulation at the wrist before and after low frequency (1 Hz) rTMS over the left motor cortex, lateral premotor cortex, sensory cortex, and also after sham stimulation. The intensity of rTMS was fixed at 1.1 times the active motor threshold at the hand area of motor cortex.
  
  
  RESULTS
  N20 peak (N20p)-P25 and P25-N33 amplitudes were suppressed after rTMS over the motor cortex, whereas the N20 onset (N20o)-N20p and SNAP amplitudes were not affected. They recovered to the baseline about 100 min after the rTMS. rTMS over the premotor cortex or sensory cortex or sham stimulation had no suppressive effect on SEPs.
  
  
  CONCLUSIONS
  The reduction of N20p-P25 and P25-N33 components without any changes of N20o-N20p amplitude suggests that the suppression occurs in the sensory cortex. rTMS (1 Hz) of the motor cortex induces a long-lasting suppression of the ipsilateral sensory cortex even at an intensity as low as 1.1 times the active motor threshold, probably via cortico-cortical pathways between motor and sensory cortex.
authors.affiliation: Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Enomoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ugawa
authors.forename: R
authors.initials: R
authors.lastname: Hanajima
authors.forename: K
authors.initials: K
authors.lastname: Yuasa
authors.forename: H
authors.initials: H
authors.lastname: Mochizuki
authors.forename: Y
authors.initials: Y
authors.lastname: Terao
authors.forename: Y
authors.initials: Y
authors.lastname: Shiio
authors.forename: T
authors.initials: T
authors.lastname: Furubayashi
authors.forename: N K
authors.initials: NK
authors.lastname: Iwata
authors.forename: I
authors.initials: I
authors.lastname: Kanazawa
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D004056:Differential Threshold; D004558:Electric Stimulation / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006225:Hand / Q000502:physiology; D006801:Humans; D008280:Magnetics; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*; D014953:Wrist / Q000294:innervation