New twists in understanding the fate of antisense oligodeoxynucleotide mRNA targets.
In this issue of Molecular Cell, Thoma et al. show that after a target mRNA is cleaved, upon treatment with an antisense oligodeoxynucleotide, the 3' cleavage product persists and is translated to produce an N-terminally truncated version of the protein encoded by the target mRNA.
Steiger
M A
MA
Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.
Decker
C J
CJ
D000818:Animals; D039603:Eukaryotic Initiation Factor-4G; D006801:Humans; D020319:Oligodeoxyribonucleotides, Antisense / Q000378:metabolism*; D010448:Peptide Initiation Factors / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D016914:Ribonuclease H / Q000378:metabolism; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D039603:Eukaryotic Initiation Factor-4G; D020319:Oligodeoxyribonucleotides, Antisense; D010448:Peptide Initiation Factors; D012333:RNA, Messenger; D016914:Ribonuclease H