Vitamin E and omega-3 fatty acids: effectors of platelet responsiveness.
This overview focuses on recent evidence in support of vitamin E and omega-3 fatty acids as positive effectors of cardiovascular health through their ability to influence signaling processes in platelets. Special emphasis is placed on vitamin E actions independent of antioxidant activity. The sometimes discordant findings among observational studies, clinical trials, and in vitro cellular studies have been scrutinized for clues to explain possible mechanisms of actions and suggest strategies for future work to define appropriate intakes of these two nutrients.
Schoene
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Nutrient Requirements & Functions Laboratory, Beltsville Human Nutrition Research Center, Building 307, Room 215, BARC-East, Beltsville, MD 20705, USA. schoene@307.bhnrc.usda.gov
D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
D015525:Fatty Acids, Omega-3; D014810:Vitamin E