title: The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men.
abstract: OBJECTIVE
  Testing association of the Asn363Ser variant of the glucocorticoid gene with measures of obesity and weight gain.
  
  
  METHODS
  741 obese subjects (BMI > or = 31 kg/m(2) at selection) and 854 random control subjects from the same population, examined at draft board examination and after on average 27.4+/- y. A lean control group (n=351) was further selected as the fraction from the cohort group having a BMI below 25.0 kg/m(2) at the latest examination.
  
  
  METHODS
  Using PCR-RFLP subjects were genotyped for the Asn363Ser variant and grouped according to genotype.
  
  
  RESULTS
  The prevalence of the Ser363 allele was 4.7% (95% Cl: 3.3-6.2%) among the obese, 4.1% (2.7-5.5%) among the random cohort subjects and 4.3% (2.1-6.5%) among lean control subjects, respectively, showing no significant differences between the groups (P > 0.1). Furthermore, no differences in BMI, waist-hip ratio or weight gain were seen within any of the groups when defined according to the glucocorticoid receptor genotype.
  
  
  CONCLUSIONS
  In the examined population this marker is not a relevant predictor of obesity.
authors.affiliation: Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark. SME@hagedorn.dk
authors.forename: S M
authors.initials: SM
authors.lastname: Echwald
authors.forename: T I
authors.initials: TI
authors.lastname: Sørensen
authors.forename: T
authors.initials: T
authors.lastname: Andersen
authors.forename: O
authors.initials: O
authors.lastname: Pedersen
mesh_terms: D000328:Adult; D000483:Alleles; D001824:Body Constitution / Q000235:genetics; D015992:Body Mass Index; D015331:Cohort Studies; D005387:Finland; D005838:Genotype; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D015430:Weight Gain / Q000235:genetics*
chemical_list: D011965:Receptors, Glucocorticoid