Extracellular matrix and keratinocyte migration.
We are just beginning to understand some of the cellular mechanisms involved in human keratinocyte migration on extracellular matrix. Extracellular matrix components have differing effects on keratinocyte motility. Signalling through integrin receptors and secretion of collagenase are both components of this process. An understanding of the effect of extracellular matrix on keratinocyte migration has direct relevance to the problem of wound re-epithelialization and will assist in the development of therapeutic efforts to enhance wound healing artificially.
O'Toole
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EA
Centre for Cutaneous Research, St Bartholomew's & The Royal London School of Medicine and Dentistry, London, UK. Edelann@aol.com
D002465:Cell Movement; D003094:Collagen / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D005353:Fibronectins / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D015603:Keratinocytes / Q000502:physiology*; D007797:Laminin / Q000502:physiology; D020782:Matrix Metalloproteinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D019096:Vitronectin / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D005353:Fibronectins; D016023:Integrins; D007797:Laminin; D019096:Vitronectin; D003094:Collagen; D020782:Matrix Metalloproteinases