Management of the pediatric liver transplant patient.
1. In pretransplant management, the prevention and treatment of malnutrition is essential for pediatric patients as malnutrition is associated with both increased pre- and posttransplant mortality. 2. Technical complications, particularly hepatic artery thrombosis, after pediatric liver transplantation are relatively common given the small size of the majority of the recipients. Early recognition is essential to reduce the associated increased risk for both patient and graft loss. 3. Immunosuppression regimens in children should aim to begin weaning of steroids within the first year after transplant because of their detrimental impact on growth. 4. Long-term immunosuppression strategies must focus on avoiding the risks of long-term immunosuppression, particularly nephrotoxicity, neurotoxicity, de novo malignancy, and late infections. 5. EBV-associated PTLD is a special problem for young pediatric liver recipients. Strategies for prevention and preemptive management are essential. 6. Noncompliance in teens is a particular problem and is associated not only with graft dysfunction, but also with graft loss and patient death. Recognizing teens at risk and providing intervention strategies require a multi-disciplinary approach.
McDiarmid
S V
SV
University of California at Los Angeles Medical Center, Los Angeles, CA 90095, USA. smcdiarmid@mednet.ucla.edu
D002648:Child; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007231:Infant, Newborn; D017053:Infection Control; D016031:Liver Transplantation; D008134:Long-Term Care; D010372:Pediatrics / Q000379:methods*; D011182:Postoperative Care; D011300:Preoperative Care; D014777:Virus Diseases / Q000517:prevention & control