Successful treatment with steroids of upper gastrointestinal acute graft vs. host disease after hematopoietic stem cell transplantation.
A 39-year-old man with acute myeloid leukemia underwent completely matched related hematopoietic stem cell transplantation. On post-transplantation day 83 he was diagnosed as having upper gastrointestinal graft-versus-host disease (GVHD) by endoscopic examination and pathological examination of endoscopic biopsy specimens, and daily administration of 60 mg of water-soluble prednisolone and 50 mg of cyclosporine was started. After steroid therapy, the symptoms of upper gastrointestinal GVHD disappeared completely and endoscopic findings dramatically improved.
Nishi
T
T
Dept. of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital, Shogoin-Kawara-cho, Sakyo-ku, Kyoto city, Kyoto 606-8507, Japan.
Okazaki
K
K
Fujii
S
S
Uchida
K
K
Uose
S
S
Nakase
H
H
Ohana
M
M
Nishihara
T
T
Chiba
T
T
D000208:Acute Disease; D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use; D016099:Endoscopy, Gastrointestinal; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007951:Leukemia, Myeloid / Q000473:pathology / Q000601:surgery*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone