Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death.
Oligodendrocyte progenitor cells were found to be vulnerable to kainate excitotoxic insults, an effect inhibited by either the selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466)) or the selective group I metabotropic glutamate (mGlu) receptor agonist, (S)-3,5-dihydroxyphenylglycine. The protective effects of (S)-3,5-dihydroxyphenylglycine were reversed by the selective mGlu receptor antagonist, (S)-alpha-methyl-4-carboxyphenylglycine. These data suggest that group I mGlu receptors may limit oligodendrocyte progenitor cell degeneration during acute brain insults.
Kelland
E E
EE
School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.
Toms
N J
NJ
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D001569:Benzodiazepines; D016923:Cell Death / Q000187:drug effects / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D009836:Oligodendroglia / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D018091:Receptors, AMPA / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D012118:Resorcinols / Q000494:pharmacology; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects
D014151:Anti-Anxiety Agents; D001565:Benzoates; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D018091:Receptors, AMPA; D018094:Receptors, Metabotropic Glutamate; D012118:Resorcinols; C104077:metabotropic glutamate receptor type 1; C061950:GYKI 52466; D001569:Benzodiazepines; C079694:alpha-methyl-4-carboxyphenylglycine; C079215:3,5-dihydroxyphenylglycine; D007608:Kainic Acid; D005998:Glycine