title: [A pilot study of low-dose TS-1 and cisplatin combination chemotherapy for advanced gastric cancer].
abstract: TS-1, a novel oral formation of 5-fluorouracil, consists of tegafur (5-FU), CDHP and Oxo. Low-dose cisplatin (CDDP) and TS-1 was evaluated in 12 patients with advanced or recurrent gastric cancer. CDDP was given biweekly at a dose of 15 mg/m2 infused for 30 minutes, and 80 mg/body of TS-1 was orally administered as many times as possible. The response rate was 41.7%. Median survival time was 13.3 months. In one case, an adverse reaction of grade 3 leucopenia was observed. Thus, thought it is necessary to watch for leucopenia, this chemotherapy could well be effective for patients with advanced or recurrent gastric cancer.
authors.affiliation: Dept. of Surgery and Gastroenterology, Keiju Medical Center.
authors.forename: T
authors.initials: T
authors.lastname: Kamata
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: G
authors.initials: G
authors.lastname: Minatoya
authors.forename: Y
authors.initials: Y
authors.lastname: Michiwa
authors.forename: I
authors.initials: I
authors.lastname: Onishi
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: N
authors.initials: N
authors.lastname: Koyasaki
authors.forename: M
authors.initials: M
authors.lastname: Kanno
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage*; D010865:Pilot Projects; D011725:Pyridines / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin