title: Total Synthesis of (-)-Reserpine Using the Chiron Approach.
abstract: A highly stereocontrolled synthesis of ring D/E precursor to reserpine has been developed starting from (-)-quinic acid as a chiral template. The total synthesis of (-)-reserpine is described through the cyclization of an immonium lactam intermediate.
authors.affiliation: Department of Chemistry, Université de Montréal, P. O. Box 6128, Station Centreville, Montréal, QC, Canada H3C 3J7.
authors.forename: Stephen
authors.initials: S
authors.lastname: Hanessian
authors.forename: Jingwen
authors.initials: J
authors.lastname: Pan
authors.forename: Andrew
authors.initials: A
authors.lastname: Carnell
authors.forename: Hervé
authors.initials: H
authors.lastname: Bouchard
authors.forename: Luc
authors.initials: L
authors.lastname: Lesage