title: The management of Sjögren's syndrome in dental practice.
abstract: BACKGROUND
  Sjögren's syndrome, or SS, is a multisystem inflammatory disorder of the exocrine glands with a wide range of extraglandular involvement. Symptoms of dry eyes and xerostomia, although not invariably present, are characteristic features of SS. An increased risk of oral and dental diseases is a prominent consequence of SS.
  
  
  METHODS
  The author reviewed recent medical and dental studies that have advanced our understanding of the causes and treatment of SS. She particularly focused on studies addressing the diagnosis and treatment of the oral component of the disease.
  
  
  RESULTS
  Sjögren's syndrome is a widely underdiagnosed disease. A delay in the diagnosis of SS may have a significant physical, psychological and economic impact on the affected person. The pathogenesis of SS appears to involve a number of factors: immunological, genetic, hormonal and possibly infectious. Successful management of SS requires a multidisciplinary approach, and the dentist plays an essential role in the diagnosis and treatment of the disease. ORAL IMPLICATIONS: Impairment of salivary function in SS increases the risk of developing oral diseases. Effective management of oral health comprises enhancement of salivary output (cholinergic agonist drugs such as pilocarpine or cevimeline) and prevention and treatment of dental caries, oral candidiasis and allergic mucositis. Finally, periodic evaluation of various clinical and laboratory parameters is needed to monitor disease status.
authors.affiliation: Salivary Dysfunction Clinic, Baylor College of Dentistry, Department of Periodontology, 3302 Gastom Ave., Dallas, Texas 75246, USA. alhashim@ont.com
authors.forename: I
authors.initials: I
authors.lastname: al-Hashimi
mesh_terms: D002177:Candidiasis / Q000188:drug therapy; D017742:Dental Care for Chronically Ill; D003731:Dental Caries / Q000517:prevention & control; D004326:Drinking; D006801:Humans; D012463:Saliva / Q000378:metabolism; D012464:Saliva, Artificial / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications* / Q000628:therapy*; D014985:Xerophthalmia / Q000209:etiology; D014987:Xerostomia
chemical_list: D012464:Saliva, Artificial