A genomewide search for quantitative-trait loci underlying asthma.
A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes were studied, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), airway responsiveness as indicated by methacholine (MTCH)-challenge test, serum total immunoglobulin E (TIgE), serum-specific immunoglobulin E, eosinophil count in peripheral blood, and skin-prick tests with three different allergens (cockroach, Dermatophagoides pteronyssinus, and D. farinae). Our study showed significant linkage between airway responsiveness to MTCH and D2S1780 on chromosome 2 (P<.00002) and provided suggestive evidence (P<.002) for six additional possible QTLs: D10S1435 and D22S685, for FEV1; D16S412, for FVC; D19S433, for airway responsiveness to MTCH; D1S518, for TIgE; and D4S1647, for skin reactivity to cockroach. No significant or suggestive evidence of linkage for the other four traits was found.
Xu
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Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA.
Fang
Z
Z
Wang
B
B
Chen
C
C
Guang
W
W
Jin
Y
Y
Yang
J
J
Lewitzky
S
S
Aelony
A
A
Parker
A
A
Meyer
J
J
Weiss
S T
ST
Xu
X
X
D000328:Adult; D000485:Allergens / Q000276:immunology; D000818:Animals; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000097:blood / Q000139:chemically induced / Q000235:genetics* / Q000276:immunology*; D016085:Bronchoconstrictor Agents / Q000494:pharmacology; D002681:China; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D003058:Cockroaches / Q000276:immunology; D004804:Eosinophils; D005260:Female; D005541:Forced Expiratory Volume / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D012882:Skin Tests; D014797:Vital Capacity / Q000235:genetics
D000485:Allergens; D039741:Antigens, Dermatophagoides; D016085:Bronchoconstrictor Agents; D006023:Glycoproteins; D016210:Methacholine Chloride; D007073:Immunoglobulin E