title: [Role of endothelial cell autoantibodies in the pathogenesis of sudden hear loss].
abstract: Sudden hearing loss can be found in systemic autoimmune diseases or it can be a symptom of an autoimmune disease of the inner ear. The present work has studied a group of patients with idiopathic sudden hearing loss to determine what role anti-endothelial cell antibodies (AECA) play as markers of immuno-mediated vasculitis of the inner ear. The study involved 32 patients with sudden deafness and 14 controls. The patients underwent otofunctional, neuroradiological, sero-microbiological and immunological testing. Using the indirect immunofluorescence technique, serum AECA were determined within 24 hours of hospitalization and three days after the onset of deafness. AECA positive patients (AECA+) were administered corticosteroid therapy (methylprednisone 1 mg/kg/die) for 1 month. A clinical follow-up was performed, including audiometry, 1 month after discharge and thereafter at three-month intervals (follow-up range: 8-18 months). AECA proved positive in 15/32 patients (47%) and in 2/14 of the controls (14%). The difference between the patients and the controls was statistically significant (p = 0.03). The 7 patient who showed no recovery after 1 month were all AECA+. None of the AECA+ patients showed other symptoms or a worsening of the hearing loss. In conclusion, the determination of non-specific autoantibodies vs. the inner ear, such as AECA, can be considered a useful clinical tool in differentiating between patients with idiopathic sudden hearing loss and those for which a diagnosis of immuno-mediated vasculitis of the inner ear is likely and for which prognosis is particularly unfavorable.
authors.affiliation: Istituto di Clinica Otorinolaringoiatrica, Università Cattolica del Sacro Cuore, Roma. iclot@rm.unicatt.it
authors.forename: G
authors.initials: G
authors.lastname: Cadoni
authors.forename: A R
authors.initials: AR
authors.lastname: Fetoni
authors.forename: S
authors.initials: S
authors.lastname: Agostino
authors.forename: A
authors.initials: A
authors.lastname: De Santis
authors.forename: P
authors.initials: P
authors.lastname: Vulpiani
authors.forename: R
authors.initials: R
authors.lastname: Manna
authors.forename: F
authors.initials: F
authors.lastname: Ottaviani
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D004727:Endothelium / Q000166:cytology* / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D003639:Hearing Loss, Sudden / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies