Insights from linked single nucleotide polymorphisms: what we can learn from linkage disequilibrium.
New methods for analyzing sequence polymorphism data have uncovered some striking patterns of linkage disequilibrium in both humans and fruitflies. These methods have revealed examples where the observed amount of linkage disequilibrium is either much more or much less than expected, and have led to advances in our understanding of the forces that affect naturally occurring genetic variation. With the recent explosion of sequence polymorphism data, the prospects for further progress from these methods are quite promising.
Wall
J D
JD
Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. jwall@oeb.harvard.edu
D000483:Alleles; D000818:Animals; D004330:Drosophila / Q000235:genetics; D005785:Gene Conversion; D014644:Genetic Variation; D005828:Genetics, Population; D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic / Q000235:genetics