title: Comparison of the biocompatibility of 2 foldable intraocular lenses with sharp optic edges.
abstract: OBJECTIVE
  To compare the clinical performance of 2 foldable intraocular lenses (IOLs) with sharp optic edges in terms of uveal and capsular biocompatibility.
  
  
  METHODS
  Department of Ophthalmology, University Hospital of Vienna, Vienna, Austria.
  
  
  METHODS
  Fifty eyes scheduled for cataract surgery were included in this comparative study. A standardized surgical protocol was used, and all operations were performed by 1 experienced surgeon. Two posterior chamber lens types of similar design with a 6.0 mm sharp-edged optic and poly(methyl methacrylate) haptics were used. Twenty-five eyes received an AcrySof acrylic IOL (Alcon), and 25 eyes received a CeeOn 911A silicone IOL (Pharmacia). Relevant data were collected at a 3-year follow-up examination. To evaluate uveal biocompatibility, anterior chamber laser flare and cell measurements and inflammatory cell reactions were monitored. Cellular biocompatibility was investigated by examining anterior capsule opacification (ACO), posterior capsule opacification (PCO), and lens epithelial cell (LEC) ongrowth on the IOL's anterior surface. Factors such as intralenticular glistenings and IOL decentration were also evaluated.
  
  
  RESULTS
  Anterior chamber flare and cells and the inflammatory cell reaction were significantly lower in the CeeOn 911A group. There was no statistically significant difference in ACO, PCO, and LEC ongrowth between the 2 groups. The AcrySof lenses showed significantly better centration and a higher density of intralenticular glistening.
  
  
  CONCLUSIONS
  The findings show that a sharp-edged optic design is, to date, the most effective method of reducing the rate of PCO. Despite a subclinical foreign-body reaction in the AcrySof group, both lenses had a high degree of capsular and uveal biocompatibility.
authors.affiliation: Department of Ophthalmology, University Hospital of Vienna, Vienna, Austria. joerg.schauersberger@akh-wien.ac.at
authors.forename: J
authors.initials: J
authors.lastname: Schauersberger
authors.forename: M
authors.initials: M
authors.lastname: Amon
authors.forename: A
authors.initials: A
authors.lastname: Kruger
authors.forename: C
authors.initials: C
authors.lastname: Abela
authors.forename: G
authors.initials: G
authors.lastname: Schild
authors.forename: J
authors.initials: J
authors.lastname: Kolodjaschna
mesh_terms: D000180:Acrylic Resins; D001672:Biocompatible Materials; D002386:Cataract / Q000175:diagnosis / Q000517:prevention & control; D002387:Cataract Extraction; D005549:Foreign-Body Reaction / Q000175:diagnosis / Q000517:prevention & control; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D011183:Postoperative Complications / Q000517:prevention & control; D011474:Prosthesis Design; D012826:Silicone Elastomers; D014602:Uvea / Q000473:pathology; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000517:prevention & control; D014792:Visual Acuity
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D012826:Silicone Elastomers