Pharmaceutical applications of size reduced grades of surfactant co-processed microcrystalline cellulose.
New grades of ultra-fine microcrystalline cellulose (MCC), without (grade X) or with variable percentage sodium lauryl sulphate (SLS; grades Y), were prepared by an ultrasonic homogenisation process from Avicel PH-101 (grade C), prior to recovery by spray-drying. Both new grade types were found to be inferior compared with grade C in a tableting application for paracetamol, resulting largely from poor flow of the feed material. However, both new grades proved superior to grade C in an aqueous extrusion/spheronisation application for the preparation of indomethacin pellets, producing smoother pellets in greater yield. Grade Y was particularly effective at delaying drug dissolution, due mainly to decreased porosity in the pellets formed and retardation of their break-up.
Levis
S R
SR
Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, Trinity College, University of Dublin, Dublin 2, Ireland.
Deasy
P B
PB
D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004339:Drug Compounding; D007213:Indomethacin / Q000008:administration & dosage / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013501:Surface-Active Agents; D013607:Tablets; D012967:Sodium Dodecyl Sulfate; D002482:Cellulose; C109691:microcrystalline cellulose; D007213:Indomethacin