Vascular inhibitory actions of 17beta-oestradiol in rat portal vein.
1. We have examined the effects of 17beta-oestradiol on spontaneous spikes and contractions to noradrenaline in rat portal vein. 2. The 17beta-oestradiol (10 microM) significantly reduced the maximum height of spontaneous spike contractions and significantly reduced the maximum contraction to noradrenaline (10 microM) in portal vein from both male and female rats. 3. The protein synthesis inhibitor cycloheximide (10 microM) did not significantly affect the inhibitory actions of 17beta-oestradiol (10 microM) against spontaneous spike contractions and contractions to noradrenaline. 4. In summary, 17beta-oestradiol diminishes spontaneous spike contractions and the contractile response to noradrenaline in rat portal vein, by a non-genomic action.
Leong
S
S
Department of Physiology, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
Docherty
J R
JR
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011169:Portal Vein / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D011500:Protein Synthesis Inhibitors; D004958:Estradiol; D003513:Cycloheximide