Combined indomethacin/gentamicin eyedrops to reduce pain after traumatic corneal abrasion.
OBJECTIVE
To evaluate the analgesic action of combined indomethacin 0.1%/gentamicin eyedrops in traumatic corneal abrasion.


METHODS
We evaluated 123 patients presenting traumatic corneal abrasion in a multicentre, randomised, double-masked study comparing two parallel treatment groups: indomethacin/gentamicin (group 1) or gentamicin alone (group 2). Study treatments were administered four times daily for 5-6 days. Pain (visual analogue scale), associated symptoms and safety were assessed.


RESULTS
Starting from a comparable level, pain was reduced by 30% in group 1 and 15% in group 2, one hour after the first instillation, and by 59% and 42% respectively after the second. The global difference in pain relief from day 0 to day 4/5 was significantly better in group 1 (p = 0.015). Associated ophthalmic symptoms showed a greater decrease in group 1 after the first instillation (p = 0.007). Both treatments were well tolerated.


CONCLUSIONS
Combined indomethacin/gentamicin eyedrops were effective and well tolerated in reducing the pain and discomfort associated with traumatic corneal abrasion.
Alberti
M M
MM
Hopital d'Instruction des Armées Desgenettes, Lyon, France.
Bouat
C G
CG
Allaire
C M
CM
Trinquand
C J
CJ
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D065306:Corneal Injuries; D004311:Double-Blind Method; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005131:Eye Injuries / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009883:Ophthalmic Solutions; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D012449:Safety
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005839:Gentamicins; D009883:Ophthalmic Solutions; D007213:Indomethacin