Long-Term outcome of neonatal Citrobacter koseri (diversus) meningitis treated with imipenem/meropenem and surgical drainage.
Neonatal Citrobacter koseri (diversus) meningitis is often complicated by the formation of brain abscesses and has a poor neurological outcome with seizures, mental retardation and paresis as sequelae in 50% of the cases. As there is emerging resistance to ampicillin, gentamicin and third-generation cephalosporins, we attempted to treat this infection with carbapenems. Carbapenems in combination with cefotaxime and surgical drainage may play an important role in treating C. koseri meningitis.
Straussberg
R
R
Dept. of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva and Sackler School of Medicine, Tel Aviv University. rachelst@post.tau.ac.il
Harel
L
L
Amir
J
J
D015780:Carbapenems / Q000627:therapeutic use*; D002439:Cefotaxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002954:Citrobacter / Q000302:isolation & purification / Q000472:pathogenicity*; D003131:Combined Modality Therapy; D004322:Drainage; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D016896:Treatment Outcome
D015780:Carbapenems; D002511:Cephalosporins; D002439:Cefotaxime