title: Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f.
abstract: The murine Nkrp1 gene family encodes three previously identified activation and inhibitory receptors expressed on natural killer (NK) cells. This family includes the gene for NKR-P1C (NK1.1), the most specific serologic marker on C57BL/6-derived NK cells and is localized in a gene cluster in the NK gene complex (NKC). To further analyze the Nkrp1 family, we constructed and analyzed a bacterial artificial chromosome contig. A genomic organization of the Nkrp1 family was obtained and three new Nkrp1 genes were isolated from interleukin-2-activated NK cells. Thus, the Nkrp1 family adds to the repertoire of receptors expressed by NK cells.
authors.affiliation: Howard Hughes Medical Institute, Division of Rheumatology, Washington University, Box 8045, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA. bplougas@im.wustl.edu
authors.forename: B
authors.initials: B
authors.lastname: Plougastel
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: C
authors.initials: C
authors.lastname: Dubbelde
authors.forename: W M
authors.initials: WM
authors.lastname: Yokoyama
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly; D000954:Antigens, Surface / Q000235:genetics*; D003001:Cloning, Molecular; D020451:Contig Mapping; D016678:Genome; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011544:Pseudogenes; D011971:Receptors, Immunologic / Q000235:genetics*; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D000099192:CD69 Antigens
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly; D000954:Antigens, Surface; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011971:Receptors, Immunologic; D000099192:CD69 Antigens; C527212:Klrb1b protein, mouse; C527211:Klrb1c protein, mouse; C442138:Nkrp1f protein, mouse