[Genetic aspects of colorectal cancer].
Cancer is a hereditary disease at the level of an individual cell and its daughter cells. The tumor genotype causing the tumor phenotype is now quite well known in colorectal cancer and allows, among others, to perform pathology examination at the molecular level. A distinct topic addresses individual predisposition to colorectal cancer. Its molecular nature is well know in the relatively rare cases, about 5-10% of colorectal cancers, where such a predisposition is major, and is transmitted in families of affected subjects following a hereditary, mendelian mode of inheritance. Specifically, two types of hereditary adenomatous tumors, polyposis and hereditary nonpolyposis colorectal cancer, may benefit from genetic analysis in order to target cancer prevention. New genetic tests will probably develop in the coming years, allowing for the analysis of more modest, and less clearly hereditary individual risks.
Abramowicz
M
M
Service de Génétique Médicale, Centre de Génétique, Laboratoire de Génétique Médicale, Hôpital Erasme, U.L.B.
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D005799:Genes, Dominant / Q000235:genetics; D005817:Genetic Counseling / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D009154:Mutation / Q000235:genetics; D011322:Primary Prevention / Q000379:methods; D012307:Risk Factors