[Changes of human recombination bone morphogenetic protein-2 in bone and marrow in tail suspended rats].
OBJECTIVE
To study human recombination bone morphogenetic protein-2 (rhBMP-2) change in bone and marrow under simulated weightlessness.


METHODS
5 SD rats were tail suspended for 14, 28 d with another 5 freely active rats as control. Histological samples were in situ hybridized.


RESULTS
rhBMP-2 expression of bone and marrow were lower in tail suspended rats than control levels (P < 0.05). rhBMP-2 expression tail suspended rats in 14 day were higher than that in 28 day suspended group (P < 0.05).


CONCLUSIONS
rhBMP-2 levels in rats bone and marrow were lower after tail suspension.
Fu
C J
CJ
Department of Oral Pathology, Stomatological collage, The Fourth Military Medical University, Xi'an 710032, China.
Yang
L J
LJ
Cao
X S
XS
Chen
X Z
XZ
Zhang
L F
LF
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D015870:Gene Expression; D019417:Hindlimb Suspension; D006801:Humans; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism*; D016212:Transforming Growth Factor beta; D018474:Weightlessness Simulation
C525718:BMP2 protein, human; C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2