title: Application of sweeping to micellar electrokinetic chromatography-atmospheric pressure chemical ionization-mass spectrometric analysis of environmental pollutants.
abstract: An application study of sweeping, an on-line sample concentration technique, to micellar electrokinetic chromatography (MEKC) directly combined with mass spectrometry (MS) using an atmospheric pressure chemical ionization (APCI) interface, namely MEKC-APCI-MS, was investigated to enhance the concentration sensitivity for the analysis of environmental pollutants. Under a neutral condition, around 100-fold increase in the concentration sensitivity was achieved for several aromatic amines and alkyl phthalates as test samples by sweeping-MEKC-APCI-MS compared to conventional MEKC-APCI-MS, whereas under an acidic condition, 100 to 600-fold sensitivity enhancement was gained for similar solutes. Linearity of the corrected peak area obtained in the mass chromatogram against the sample concentration was examined for 3,4-dichloroaniline and diisopropyl phthalate (DIPP). The estimated limits of detection for 3,4-dichloroaniline and DIPP were 0.6 and 0.4 ppm, respectively, in terms of the injected sample concentration.
authors.affiliation: Department of Material Science, Faculty of Science, Himeji Institute of Technology, Kamigori, Hyogo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Isoo
authors.forename: K
authors.initials: K
authors.lastname: Otsuka
authors.forename: S
authors.initials: S
authors.lastname: Terabe
mesh_terms: D000588:Amines / Q000032:analysis*; D001274:Atmospheric Pressure; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis*; D016014:Linear Models; D013058:Mass Spectrometry / Q000379:methods*; D010795:Phthalic Acids / Q000032:analysis*; D014466:Ultraviolet Rays
chemical_list: D000588:Amines; D004785:Environmental Pollutants; D010795:Phthalic Acids