Motor abnormality in the gastroduodenal junction in patients with infantile hypertrophic pyloric stenosis.
OBJECTIVE
Periodic clusters of phasic pressure waves in the gastroduodenal junction (GDJ) have been seen in patients with infantile hypertrophic pyloric stenosis (IHPS). This study investigated the details of these pressure waves in relation to disturbed transpyloric flow in IHPS.


METHODS
Manometric study was performed in 11 IHPS patients before and after atropine therapy and 2 non-IHPS infants. Pressure changes in the GDJ were measured with an 8-channel sleeve or a 9-channel sidehole micromanometric assembly under fluoroscopic control for 2 hours.


RESULTS
Clusters of phasic pressure waves (365 +/- 42 mm Hg) associated with an increase in basal pressure (10 +/- 3 mm Hg) were intermittently observed in the GDJ in all IHPS patients. Similar observations were not made in the non-IHPS infants. Most antral pressure waves occurred simultaneously with those pressure waves in the GDJ in the IHPS patients. Atropine (0.01 mg/kg) transiently abolished the phasic and tonic pressure waves for 19 +/- 10 minutes. Significantly fewer phasic pressure waves were observed after atropine therapy.


CONCLUSIONS
Characteristic phasic and tonic contractile activity in the GDJ is uncoordinated with the antral contractions in IHPS patients. Such incoordination may be an important factor in the disturbed transpyloric flow in IHPS.
Kawahara
H
H
Department of Pediatric Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka Suita, Osaka, Japan 565-0871.
Imura
K
K
Yagi
M
M
Kubota
A
A
Okada
A
A
D001285:Atropine / Q000627:therapeutic use; D004943:Esophagogastric Junction / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D006984:Hypertrophy / Q000503:physiopathology; D007223:Infant; D008365:Manometry; D010276:Parasympatholytics / Q000627:therapeutic use; D011707:Pyloric Stenosis / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*
D010276:Parasympatholytics; D001285:Atropine