Purine receptor agonists protect the genome of plant and animal cells from clastogen damage.
Purine receptor agonists adenosine, cyclohexyladenosine, phenylisopropyladenosine, dimethylaminopurine riboside, ATP, and ADP reduced the level of chromosome aberrations and the number of micronuclei induced by ethylmethane sulfonate and cyclophosphamide in plants (Crepis capillaris) and mice. Possible mechanisms of the protective effect of these ligands are discussed.
Kharitonov
V S
VS
Kazan State Medical University; Kazan State University.
Semenov
V V
VV
Barabanshchikov
B I
BI
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000502:physiology; D002869:Chromosome Aberrations; D027468:Crepis / Q000187:drug effects / Q000235:genetics*; D003520:Cyclophosphamide / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D058913:Purinergic Agonists; D011983:Receptors, Purinergic / Q000378:metabolism
D008024:Ligands; D009153:Mutagens; D058913:Purinergic Agonists; D011983:Receptors, Purinergic; D003520:Cyclophosphamide; D005020:Ethyl Methanesulfonate