An Improved Synthesis of O-Benzoyl Protected Hydroxamates.
Several primary amines (R-NH(2)) were converted to their corresponding O-benzoyl protected hydroxamates under biphasic conditions. The intermediate (benzoyloxy)amines (R-NHOCOPh) were generated using benzoyl peroxide dissolved in CH(2)Cl(2) and an aqueous carbonate buffer (pH 10.5) at room temperature. Subsequent acylation with R'COCl gave the protected hydroxamates (R'CONROCOPh) in good overall yields (56-89%).
Wang
Queenie Xianghong
QX
Department of Chemistry, University of Central Florida, Orlando, Florida 32816.
King
Jennifer
J
Phanstiel IV
Otto
O