[Methotrexate-ciprofloxacin interaction: report of two cases of severe intoxication].
Methotrexate elimination may be delayed by different drugs. Such a delay may produce severe toxic complications.


METHODS
We report two cases of adolescents treated for malignant diseases who presented a delayed methotrexate elimination even though they received ciprofloxacin. The first patient had already received several courses of methotrexate without toxicity before this episode. The second patient tolerated methotrexate when ciprofloxacin was not associated to the treatment.


CONCLUSIONS
High-dose methotrexate-ciprofloxacin association should be avoided.
Dalle
J H
JH
Clinique de pédiatrie, unité d'hémato-oncologie pédiatrique, centre hospitalier régional universitaire de Lille, hôpital Jeanne-de-Flandre, 59037 Lille, France. jhdalle@wanadoo.fr
Auvrignon
A
A
Vassal
G
G
Leverger
G
G
Kalifa
C
C
D000293:Adolescent; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000493:pharmacokinetics*; D001859:Bone Neoplasms / Q000188:drug therapy; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000493:pharmacokinetics; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000493:pharmacokinetics*; D009447:Neuroblastoma / Q000188:drug therapy; D012516:Osteosarcoma / Q000188:drug therapy
D000890:Anti-Infective Agents; D000964:Antimetabolites, Antineoplastic; D002939:Ciprofloxacin; D008727:Methotrexate