Myostatin in muscle growth and repair.
Myostatin, a member of the TGF beta superfamily, regulates skeletal muscle size by controlling embryonic myoblast proliferation. Recent results show that myostatin may also have a role in muscle regeneration and muscle wasting of adult animals. This review summarizes the recent developments in the regulation of myostatin gene expression and mechanism of its function.
Sharma
M
M
Animal Genomics, AgResearch, Hamilton, New Zealand.
Langley
B
B
Bass
J
J
Kambadur
R
R
D000818:Animals; D015870:Gene Expression; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000196:embryology / Q000502:physiology*; D055435:Myostatin; D012038:Regeneration / Q000502:physiology*; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology*
C525911:MSTN protein, human; D055435:Myostatin; D016212:Transforming Growth Factor beta