title: (+)-epi-Alpha-bisabolol [correction of bisbolol] is the wound-healing principle of Peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids.
abstract: Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-alpha-bisabolol (1) (ED(50) 155 microg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, alpha-bisabolol (2) and alpha-terpineol (3) (ED(50) of 228 and 240 microg/g mouse[corrected], respectively).
authors.affiliation: Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA.
authors.forename: L F
authors.initials: LF
authors.lastname: Villegas
authors.forename: A
authors.initials: A
authors.lastname: Marçalo
authors.forename: J
authors.initials: J
authors.lastname: Martin
authors.forename: I D
authors.initials: ID
authors.lastname: Fernández
authors.forename: H
authors.initials: H
authors.lastname: Maldonado
authors.forename: A J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: G B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D016475:3T3 Cells / Q000187:drug effects; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D005204:Farnesol / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D000081222:Monocyclic Sesquiterpenes; D039821:Monoterpenes; D010568:Peru; D026321:Piperaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000494:pharmacology; D018675:Toxicity Tests; D014945:Wound Healing
chemical_list: D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D000081222:Monocyclic Sesquiterpenes; D039821:Monoterpenes; D010936:Plant Extracts; D012717:Sesquiterpenes; D013729:Terpenes; C016775:alpha-terpineol; C004497:bisabolol; D005204:Farnesol