Apoptosis in lupus pathogenesis.
Apoptosis has been implicated in lupus pathogenesis in at least three different ways. As antigen, apoptotic material drives autoimmune responses. As immune modulator, impaired apoptosis makes patients susceptible to developing autoimmunity. As effector mechanism, apoptosis participates in target organ injury. This review summarizes the evidence that links apoptosis to these components of lupus pathogenesis.
Greidinger
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Division of Immunology and Rheumatology, University of Missouri, One Hospital Drive, Columbia, Missouri 65212, USA. greidingere@health.missouri.edu
D017209:Apoptosis / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D006801:Humans; D008177:Lupus Vulgaris / Q000209:etiology / Q000276:immunology* / Q000473:pathology*
D001324:Autoantigens