Determination of lignocaine and amprolium in pharmaceutical formulations using AAS.
The ion-associate complexes of lignocaine hydrochloride (Lig.Cl) with ammonium reineckate (Rk) or sodium cobaltithiocyanate, and that of amprolium hydrochloride (Amp.Cl) with ammonium reineckate, have been prepared. The precipitated ion-associates were subjected to elemental analyses, infrared and nuclear magnetic resonance spectroscopy and determination of the metal content for elucidation of their structures. The solubilities of the solid ion-associate complexes have been studied and their solubility products were determined at different temperatures at the optimum pH for their quantitative precipitation. The thermodynamic parameters DeltaH, DeltaG and DeltaS for the dissolution of the ion-associate complexes were calculated. These ion-associate complexes have been used for the quantitative determination of the above mentioned drugs by precipitating them with an excess of the inorganic metal complex ions and determining the excess metal complex ions using atomic absorption spectrometry. The method was applied for the determination of the above drugs in pure solution and pharmaceutical preparations. 0.135-135.4 and 0.158-157.6 mg of lignocaine and amprolium, respectively, can be determined with mean relative standard deviations (R.S.D.) 0.92-1.20% and recovery values of 99.18+/-0.48 to 100.12+/-0.34% indicating high precision and accuracy.
El-Hawary
W F
WF
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
D000670:Amprolium / Q000032:analysis*; D000779:Anesthetics, Local / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D003049:Coccidiostats / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007294:Inositol / Q000031:analogs & derivatives; D008012:Lidocaine / Q000032:analysis*; D012995:Solubility; D013054:Spectrophotometry, Atomic
D000779:Anesthetics, Local; D003049:Coccidiostats; C030790:validamycin A; D007294:Inositol; D008012:Lidocaine; D000670:Amprolium