Octreotide-induced suppression of the hyperglycemic response to neostigmine or bombesin: relationship to hypothalamic noradrenergic drive.
Neostigmine (cholinesterase inhibitor) or bombesin, when injected into the third cerebral ventricle of awake rat, dose-dependently increased serum glucose with the simultaneous rise in hypothalamic noradrenergic neuronal activity (NAA). Co-administration of octreotide with neostigmine or bombesin suppressed the hypothalamic NNA response with the simultaneous inhibition of the hyperglycemic response. There was a close relationship between hypothalamic NNA and serum glucose in these studies. On the basis of the concept that hypothalamic noradrenergic drive plays an important role in mediating the hyperglycemic response to stressful stimuli, the present findings suggest that the hyperglycemic response to neostigmine or bombesin is mediated via the interaction with hypothalamic noradrenergic neurons.
Gotoh
M
M
Department of Laboratory Medicine, Aichi Medical University School of Medicine, 21-Karimata, Nagakute, 480-1195, Aichi, Japan. mgotoh@amugw.aichi-med-u.ac.jp
Takagi
J
J
Mori
S
S
Yatoh
M
M
Hirooka
Y
Y
Yamanouchi
K
K
Smythe
G A
GA
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001839:Bombesin / Q000008:administration & dosage*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006728:Hormones / Q000008:administration & dosage*; D006943:Hyperglycemia / Q000097:blood / Q000517:prevention & control*; D007031:Hypothalamus / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives* / Q000378:metabolism; D008845:Microinjections; D009388:Neostigmine / Q000008:administration & dosage*; D009638:Norepinephrine / Q000502:physiology*; D015282:Octreotide / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D002800:Cholinesterase Inhibitors; D006728:Hormones; D009388:Neostigmine; D008734:Methoxyhydroxyphenylglycol; D001839:Bombesin; D015282:Octreotide; C010117:3,4-dihydroxyphenylglycol; D009638:Norepinephrine