New cytotoxic sesterterpenes from the sponge Sarcotragus species.
Five new (1-3, 5, and 7) and two known (4, 6) furanosesterterpene tetronic acids were isolated from the marine sponge Sarcotragus sp. by bioactivity-guided fractionation. These compounds showed cytotoxicity against a panel of five human tumor cell lines. The gross structures were established on the basis of NMR and MS analyses. The compounds showed interesting variations of geometry and absolute configuration.
Liu
Y
Y
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
Bae
B H
BH
Alam
N
N
Hong
J
J
Sim
C J
CJ
Lee
C O
CO
Im
K S
KS
Jung
J H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007723:Korea; D007814:Larva / Q000187:drug effects; D008175:Lung Neoplasms; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009380:Neoplasms, Nerve Tissue; D010051:Ovarian Neoplasms; D011161:Porifera / Q000737:chemistry*; D012878:Skin Neoplasms; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D005663:Furans; D013729:Terpenes