New Chiral Dichlorophosphines and Their Use in the Synthesis of Phosphetane Oxides and Phosphinic Chlorides.
Myrtanyl-, bornyl- and isopinocampheyldichlorophosphines have been prepared from the corresponding alkyl chlorides via diastereospecific reactions of the Grignard reagents with PCl(3) or (Et(2)N)(2)PCl. Two applications of these compounds to synthetic asymmetric organophosphorus chemistry have been examined: their reactions with 2,3,3-trimethylbutene and AlCl(3) afford either P-chiral phosphetane oxides or, in the presence of gaseous HCl, P-chiral phosphinic chlorides with moderate to high diastereoselectivity.
Marinetti
Angela
A
Laboratoire Hétéroéléments et Coordination, CNRS URA 1499, DCPH, Ecole Polytechnique, 91128 Palaiseau, France.
Buzin
François-Xavier
FX
Ricard
Louis
L