Viruses, dendritic cells and the lung.
The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but viruses have developed survival tactics to either evade or diminish the immune system that functions to kill and eliminate these micro-organisms. In the present review we summarize current concepts regarding the function of DCs in the immune system, our understanding of how viruses alter DC function to attenuate both the virus-specific and global immune response, and how we may be able to exploit DC function to prevent or treat viral infections.
Peebles
R S
RS
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Graham
B S
BS
D000818:Animals; D000938:Antigen-Presenting Cells / Q000502:physiology; D003713:Dendritic Cells / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*