title: Correlation of Solution and Gas Phase Complexation Assessed by Electrospray Ionization Mass Spectrometry: Application to One-, Two-, and Three-Ring Macrocycles.
abstract: Electrospray ionization mass spectrometry (ESI-MS) was used to probe multiple cation complexation by C(12)H(25)<N18N>(CH(2))(12)<N18N>(CH(2))(12)<N18N>C(12)H(25), 2, and <18N>CH(2)C(6)H(4)CH(2)<N18>, 3. Complexation of two cations (2Na(+), 2 K(+), or Na(+) and K(+)) by 3 and three cations by 2 (3 Na(+), 3 K(+), and mixtures) as well as mixed proton-metallic cation complexes of both were observed. The K(+)/Na(+) cation-binding selectivity of 18-crown-6 was studied by ESI-MS of a methanol solution, and the selectivity profile was favorably compared with data obtained previously by ion-selective electrode techniques in the same solvent.
authors.affiliation: Bioorganic Chemistry Program and Department of Molecular Biology & Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St. Louis, Missouri 63110.
authors.forename: Keshi
authors.initials: K
authors.lastname: Wang
authors.forename: George W.
authors.initials: GW
authors.lastname: Gokel