title: Selective internal radiation therapy by yttrium-90 microspheres for hepatocellular carcinoma after renal transplantation.
abstract: We report a HBsAg-positive patient who developed hepatocellular carcinoma (HCC) 7 years after cadaveric kidney transplantation. The tumor was unresectable because of coexisting cirrhosis. Selective internal radiation (SIR) therapy, a novel therapy with the technique recently perfected, was used. Yttrium-90 microspheres were given via an angiographic catheter under fluoroscopy guidance. Serum alpha-fetal protein (AFP) was normalized within 2 wk. A follow-up abdominal CT scan revealed significant necrosis of the tumor and compensatory hypertrophy of non-diseased liver. The treatment was well tolerated except for transient liver function deterioration. The patient enjoyed 15 months of symptom-free survival before she died of liver failure. Practical aspects and potential applications of SIR therapy in this group of patients are discussed.
authors.affiliation: Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China. ccszeto@cuhk.edu.hk
authors.forename: C C
authors.initials: CC
authors.lastname: Szeto
authors.forename: T Y
authors.initials: TY
authors.lastname: Wong
authors.forename: C B
authors.initials: CB
authors.lastname: Leung
authors.forename: T W
authors.initials: TW
authors.lastname: Leung
authors.forename: A Y
authors.initials: AY
authors.lastname: Wang
authors.forename: S F
authors.initials: SF
authors.lastname: Lui
authors.forename: P K
authors.initials: PK
authors.lastname: Li
mesh_terms: D000328:Adult; D001918:Brachytherapy / Q000379:methods; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy*; D005260:Female; D006514:Hepatitis B Surface Antigens; D006801:Humans; D016030:Kidney Transplantation; D008113:Liver Neoplasms / Q000532:radiotherapy*; D008863:Microspheres; D015021:Yttrium Radioisotopes / Q000008:administration & dosage*
chemical_list: D006514:Hepatitis B Surface Antigens; D015021:Yttrium Radioisotopes