Change in cytokeratin 19 fragment level according to the severity of pulmonary alveolar proteinosis.
A 48-year-old man was diagnosed with primary alveolar proteinosis (PAP). Whole lung lavage was performed for treatment, and the opacity on his chest X-ray completely disappeared. The value of cytokeratin 19 fragment (CYFRA) in the serum was high at the beginning, decreased after lung lavage, and became elevated again when the disease recurred 7 months later. As PAP is thought to be a problem of surfactant secreted from type II pneumocytes, and a cytokeratin is present in the alveolar epithelial tissue, the value of serum CYFRA might be related to the severity of PAP.
Minakata
Y
Y
Third Department of Internal Medicine, Wakayama Medical University, School of Medicine.
Kida
Y
Y
Nakanishi
H
H
Nishimoto
T
T
Yukawa
S
S
D015415:Biomarkers / Q000097:blood; D006801:Humans; D007633:Keratins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011649:Pulmonary Alveolar Proteinosis / Q000097:blood*; D012008:Recurrence; D012720:Severity of Illness Index
D015415:Biomarkers; D007633:Keratins