title: The use of sweet rolls fortified with iron bis-glycinate chelate in the prevention of iron deficiency anemia in preschool children.
abstract: The effectiveness of bread fortified with iron bis-glycinate chelate for the control of iron deficiency and iron deficiency anemia was evaluated in 89 preschool children from families of low socioeconomic level attending 2 day nurseries of the Sao Paulo City Council. During the intervention's time of 6 months the children received besides their usual center's diet, a daily supplement of two sweet rolls fortified with 2 mg each of iron from the chelate for a total daily iron intake of 4 mg. After six months of intervention there was a significant decrease in the prevalence of iron deficiency anemia from 62 to 22%. There was a mean hemoglobin improvement of 1.1 g/dL, and in children with initial hemoglobin levels < 11 g/dL the mean increase in hemoglobin was 1.42 g/dL. The total mean plasma ferritin values increased from 11.34 to 20.2 micrograms/L, and in those children originally iron depleted the ferritin values normalized. A significant increase in the "z" score for weight/height was also observed. We concluded that the use of sweet rolls fortified with 2 mg of iron from the bis-glycinate chelate is highly effective for the control of iron deficiency and iron deficiency anemia in young children.
authors.affiliation: Health and Nutrition Research Center, San Marcos University, Federal University, Sao Paulo, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: Giorgini
authors.forename: M
authors.initials: M
authors.lastname: Fisberg
authors.forename: R A
authors.initials: RA
authors.lastname: De Paula
authors.forename: A M
authors.initials: AM
authors.lastname: Ferreira
authors.forename: J
authors.initials: J
authors.lastname: Valle
authors.forename: J A
authors.initials: JA
authors.lastname: Braga
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000453:epidemiology / Q000517:prevention & control*; D000886:Anthropometry; D001938:Brazil / Q000453:epidemiology; D001939:Bread; D002648:Child; D002675:Child, Preschool; D005260:Female; D005293:Ferritins / Q000097:blood; D005296:Ferrous Compounds / Q000627:therapeutic use*; D005527:Food, Fortified; D005998:Glycine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D000090463:Iron Deficiencies; D008297:Male; D015995:Prevalence; D016896:Treatment Outcome
chemical_list: D005296:Ferrous Compounds; D006454:Hemoglobins; D007502:Iron Chelating Agents; C073588:bis-glycino iron II; D005293:Ferritins; D005998:Glycine