[Effect of loratadine in children with allergic rhinitis].
The authors examined 25 children with allergic rhinitis, who were sensitive to grass, weed and tree pollens. During the allergic season nasal lavage was performed then repeated after 4 weeks of loratadine treatment. Tryptase, IL-5, ECP, TNF-alpha and RANTES levels were measured from the nasal lavage fluid. Tryptase, IL-5, and ECP levels were decreased significantly while the decrease of RANTES and TNF-alpha levels was not significant. The authors emphasize that loratadine is an effective anti-inflammatory drug which affects the early and late phase of immediate hypersensitivity. In the moderate cases loratadine is enough to relieve the symptoms, while in the severe forms anti-allergic eye drops and nasal antihistamine or steroid spray has to be added.
Kósa
L
L
Légzésfunkciós Osztály, Svábhegyi Allami Gyermekgyógyintézet, Budapest.
Kovács
N
N
Halász
A
A
Zsigmond
G
G
D000293:Adolescent; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D001798:Blood Proteins / Q000378:metabolism; D018946:Chemokine CCL5 / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D047091:Eosinophil Granule Proteins; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D015848:Interleukin-5 / Q000378:metabolism; D017336:Loratadine / Q000627:therapeutic use*; D008297:Male; D009666:Nose; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000378:metabolism*; D012260:Ribonucleases; D012697:Serine Endopeptidases / Q000378:metabolism; D007507:Therapeutic Irrigation; D053802:Tryptases; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018926:Anti-Allergic Agents; D001798:Blood Proteins; D018946:Chemokine CCL5; D047091:Eosinophil Granule Proteins; D006634:Histamine H1 Antagonists; D018836:Inflammation Mediators; D015848:Interleukin-5; D014409:Tumor Necrosis Factor-alpha; D017336:Loratadine; D012260:Ribonucleases; D012697:Serine Endopeptidases; D053802:Tryptases