title: Regression of primary high-grade gastric B-cell lymphoma following Helicobacter pylori eradication.
abstract: The causative association between Helicobacter pylori and gastric mucosal inflammation is well established. The inflammatory process leads to the acquisition of mucosa-associated lymphoid tissue (MALT) by the stomach. Evidence links H. pylori gastritis with the development of low-grade primary gastric lymphoma with a phenotype specific for lymphoma of MALT type. It is now accepted that primary low-grade MALT lymphomas regress with H. pylori eradication therapy. However, the response of primary, diffuse, large-cell gastric lymphoma to H. pylori eradication therapy is still not established. We report a case of a primary high-grade gastric lymphoma regressing after H. pylori eradication therapy.
authors.affiliation: West Wales General Hospital, Carmarthen, UK. lmroz@Salam27.freeserve.co.uk
authors.forename: I
authors.initials: I
authors.lastname: Salam
authors.forename: D
authors.initials: D
authors.lastname: Durai
authors.forename: J K
authors.initials: JK
authors.lastname: Murphy
authors.forename: B
authors.initials: B
authors.lastname: Sundaram
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000368:Aged; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D064747:Lansoprazole; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000473:pathology; D009365:Neoplasm Regression, Spontaneous; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D064747:Lansoprazole; D009853:Omeprazole