title: Synthesis and Studies of Mononucleoside Glucosyl Phosphotriester Derivatives.
abstract: The synthesis and stability studies in several aqueous media of mononucleoside glucosyl phosphotriester derivatives of 3'-azido-3'-deoxythymidine are reported herein. Such neutral mononucleotides, which incorporate beta-glucopyranosidyl moieties associated to a thioethyl linker as phosphate protecting groups were designed to act as "pronucleotides", giving rise to the corresponding 5'-mononucleotide through a glucosidase-mediated activation mechanism.
authors.affiliation: Laboratoire de Chimie Bioorganique, U.M.R. C.N.R.S. 5625, Case Courrier 008, Université Montpellier II, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Schlienger
authors.forename: Christian
authors.initials: C
authors.lastname: Périgaud
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Imbach