title: [A case of pulmonary inflammatory pseudotumor with hypergammaglobulinemia, elevated ANA, and uveitis].
abstract: A 63-year-old man presented with a chronic myeloproliferative disorder complicated with left pneumonia. His pneumonia was cured with antibiotics, but a nodular lesion remained in his chest radiographs together with hypergammaglobulinemia, a high titer of anti-nuclear antigen, and uveitis with secondary glaucoma. Specimens obtained by transbronchial lung biopsy showed a mixed accumulation of plasma cells, lymphocytes, and histiocytes as well as a spindle cell proliferation diagnosed as pulmonary inflammatory pseudotumor. The specimen did not show any recombination indicative of a heavy or a light chain of immunoglobulin in Southern blotting analysis. Oral prednisolone treatment improved the pulmonary nodular lesion, the abnormal laboratory data, and the uveitis. These findings suggest that much of the gammaglobulin produced by plasma cells in the inflammatory pseudotumor caused a variety of clinical symptoms.
authors.affiliation: Department of Medicine (II), Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Kaizu
authors.forename: T
authors.initials: T
authors.lastname: Takada
authors.forename: H
authors.initials: H
authors.lastname: Moriyama
authors.forename: M
authors.initials: M
authors.lastname: Terada
authors.forename: E
authors.initials: E
authors.lastname: Suzuki
authors.forename: F
authors.initials: F
authors.lastname: Gejyo
authors.forename: K
authors.initials: K
authors.lastname: Kuwabara
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
mesh_terms: D000284:Administration, Oral; D000974:Antibodies, Antinuclear / Q000097:blood*; D002908:Chronic Disease; D005901:Glaucoma / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications; D016726:Plasma Cell Granuloma, Pulmonary / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000974:Antibodies, Antinuclear; D011239:Prednisolone