title: frizzled 9 is expressed in neural precursor cells in the developing neural tube.
abstract: The wnt signaling pathway has important functions in nervous system development. To better understand this process we have cloned and analyzed the expression of the wnt receptor, frizzled 9, in the developing nervous system in mouse, chick and zebrafish. The earliest expression of mouse frizzled 9 mRNA expression begins at E8.5 with expression throughout the entire rostral-caudal neuraxis. This early expression pattern within the neural tube appears to be conserved between chick and zebrafish. Expression becomes restricted to a ventral domain in the mouse ventricular zone at E11.5, a region specified to give rise to neurons and glia. Using a polyclonal antibody to MFZ9 further shows expression limited to neural restricted precursors cells.
authors.affiliation: Department of Neurobiology and Anatomy, University of Utah School of Medicine, 50 N Medical Drive, Salt Lake City, UT 84132, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Van Raay
authors.forename: Y K
authors.initials: YK
authors.lastname: Wang
authors.forename: M R
authors.initials: MR
authors.lastname: Stark
authors.forename: J T
authors.initials: JT
authors.lastname: Rasmussen
authors.forename: U
authors.initials: U
authors.lastname: Francke
authors.forename: M L
authors.initials: ML
authors.lastname: Vetter
authors.forename: M S
authors.initials: MS
authors.lastname: Rao
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002490:Central Nervous System / Q000166:cytology* / Q000196:embryology*; D002642:Chick Embryo; D003001:Cloning, Molecular; D017124:Conserved Sequence; D051157:Frizzled Receptors; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity; D010802:Phylogeny; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000235:genetics* / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D013234:Stem Cells / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology / Q000235:genetics; D029961:Zebrafish Proteins
chemical_list: D051157:Frizzled Receptors; C498591:Fzd3a protein, zebrafish; C403212:Fzd9 protein, mouse; D012333:RNA, Messenger; D017981:Receptors, Neurotransmitter; D029961:Zebrafish Proteins