Spectrophotometric and some thermodynamic parameters of the charge transfer complexation between chloranilic acid and chlorpheniramine.
The principle of charge transfer complexation involving a pi-acceptor (chloranilic acid) and an n-donor (chlorpheniramine) was utilized in the assay of the later in its pure form and in its tablet dosage forms. Some thermodynamic parameters of the complex such as association constant (Kc), molar absorptivity (epsilon c), free energy change (delta G degree), enthalpy (delta H degree) and entropy (delta S degree) changes were determined to establish the stability of the complex and the optimum conditions for the complex formation. The values obtained for these thermodynamic parameters indicated that the complex formed between this two chemical entities is highly stable. Assay of chlorpheniramine in its pure form and in its tablet dosage forms gave high percentage recoveries. The principle of charge transfer complexation could therefore be employed in the colorimetric assay of chlorpheniramine in its tablet dosage forms.
Ofoefule
S I
SI
Department of Pharmaceutical Technology & Ind. Pharmacy, University of Nigeria, Nsukka, Nigeria.
Ajali
U
U
D016227:Benzoquinones / Q000737:chemistry*; D002744:Chlorpheniramine / Q000737:chemistry*; D004563:Electrochemistry; D004583:Electrons; D007202:Indicators and Reagents; D013607:Tablets; D013816:Thermodynamics
D016227:Benzoquinones; D007202:Indicators and Reagents; D013607:Tablets; D002744:Chlorpheniramine; C014400:chloranilic acid