title: Therapy for otitis-prone children in Tenshi hospital.
abstract: With the recent emergence and increases of multiple-drugs-resistant Streptococcus pneumoniae, we have been seeing an increasing number of infants with intractable recurrent otitis media which is resistant to the general conservative out-patient treatments such as oral administration of medicines or tympanotomy. In this study, we investigated the inflammation-causing bacteria in the infants with otitis media which were treated in our hospital from January to December in 1997, and in six serious cases among them, we measured IgG subclass and specific IgG2 antibody to S. pneumoniae to examine them. As a result, S. pneumoniae was found to be the cause in 45% of the cases of initial development of otitis media, and in 88% of them the S. pneumoniae was penicillin-resistant. The level of specific IgG2 antibody to S. pneumoniae was low in all the cases, whereas IgG2 subclass was deficient only in one out of the six cases; from these findings, the selectively low level of immune status was thought to be the cause of the recurrences of otitis media. In two cases, clinical condition was markedly improved by immunoglobulin substitute therapy, which demonstrates that immunoglobulin is effective for the intractable recurrent otitis media in infants.
authors.affiliation: Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo, Japan. michey@med.hokudai.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Matsumura
authors.forename: S
authors.initials: S
authors.lastname: Fukuda
authors.forename: E
authors.initials: E
authors.lastname: Chida
authors.forename: Y
authors.initials: Y
authors.lastname: Mesuda
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
authors.forename: Y
authors.initials: Y
authors.lastname: Inuyama
mesh_terms: D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007136:Immunoglobulins / Q000627:therapeutic use*; D007223:Infant; D007564:Japan; D008297:Male; D010033:Otitis Media / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D007074:Immunoglobulin G; D007136:Immunoglobulins; C035483:venilon