Synthesis and Studies of Mononucleoside Glucosyl Phosphotriester Derivatives.
The synthesis and stability studies in several aqueous media of mononucleoside glucosyl phosphotriester derivatives of 3'-azido-3'-deoxythymidine are reported herein. Such neutral mononucleotides, which incorporate beta-glucopyranosidyl moieties associated to a thioethyl linker as phosphate protecting groups were designed to act as "pronucleotides", giving rise to the corresponding 5'-mononucleotide through a glucosidase-mediated activation mechanism.
Schlienger
Nathalie
N
Laboratoire de Chimie Bioorganique, U.M.R. C.N.R.S. 5625, Case Courrier 008, Université Montpellier II, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
Périgaud
Christian
C
Gosselin
Gilles
G
Imbach
Jean-Louis
JL