title: Upper tract transitional cell carcinoma following cystectomy for bladder cancer.
abstract: OBJECTIVE
  We assessed the incidence of upper urinary tract tumors (UUTTs) after cystectomy for invasive or superficial transitional cell carcinoma (TCC) of the bladder. The risk factors, patients' characteristics and evolution of those who developed UUTTs are analyzed.
  
  
  METHODS
  From August 1980 to February 1994, 568 radical cystectomies were performed for TCC of the bladder: in 469 instances (82.5%) due to invasive tumor (T2-T4), and in 99 cases (17.5%) for superficial tumor (Ta, T1, Tis). All patients were followed for at least 5 years or until death. A retrospective study of patients who developed UUTTs has been performed. A revision of bladder tumor and UUTT characteristics, and the intervals between both is also evaluated.
  
  
  RESULTS
  26 patients (4.5%) developed UUTTs: 11 of the 99 patients cystectomized for superficial TCCs (11.1%); 6 of the 392 patients with primary invasive TCC (1.5%), and 9 of the 77 (11.6%) patients with invasive tumors and a prior history of superficial TCC. The interval to the development of UUTT was higher after cystectomy for superficial tumor. TCCs of the bladder that subsequently developed UUTTs were high grade in 84%, multifocal in 80%, or had carcinoma in situ in 65%, tumor in the prostatic urethra in 52%, and involvement of the distal ureter in 57%. Twenty-two UUTTs (84%) were located in the calyces or the renal pelvis, 3 were bilateral (11.5%), 14 multiple (58%) and 4 superficial (16%). With a median follow-up time of 18 (range 3-103) months, 14 patients (53.8%) died of tumor, 2 were alive with disease, 2 were lost for follow-up, and 8 (30%) were alive and free of disease.
  
  
  CONCLUSIONS
  We found that patients cystectomized for superficial or invasive TCC with a prior history of superficial TCC have a higher incidence of UUTTs. These cases require follow-up with annual urography or loopography.
authors.affiliation: Department of Urology, Fundacíó Puigvert, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Huguet-Pérez
authors.forename: J
authors.initials: J
authors.lastname: Palou
authors.forename: F
authors.initials: F
authors.lastname: Millán-Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: Salvador-Bayarri
authors.forename: H
authors.initials: H
authors.lastname: Villavicencio-Mavrich
authors.forename: J
authors.initials: J
authors.lastname: Vicente-Rodríguez
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology*; D015653:Cystectomy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D014516:Ureteral Neoplasms / Q000453:epidemiology*; D014523:Urethral Neoplasms / Q000453:epidemiology*; D001749:Urinary Bladder Neoplasms / Q000601:surgery*