Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time.
Ocimum sanctum fixed oil produced hypotensive effect in anaesthetised dog, which seems to be due to its peripheral vasodilatory action. The oil increased blood-clotting time and percentage increase was comparable to aspirin and could be due to inhibition of platelet aggregation. The oil also increased pentobarbitone-induced sleeping time in rats indicating probable inhibitory effect of oil towards cytochromic enzyme responsible for hepatic metabolism of pentobarbitone.
Singh
S
S
College of Pharmacy, University of Delhi, Pushp Vihar, 110017, New Delhi, India.
Rehan
H M
HM
Majumdar
D K
DK
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D006993:Hypnotics and Sedatives; D010938:Plant Oils; C080118:ocimum oil; D010424:Pentobarbital; D001241:Aspirin