title: Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation.
abstract: OBJECTIVE
  The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD.
  
  
  METHODS
  Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength.
  
  
  RESULTS
  PTSD subjects showed significantly less activation of the thalamus, the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10/11) than did the comparison subjects.
  
  
  CONCLUSIONS
  The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.
authors.affiliation: Department of Psychiatry, University of Western Ontario, London, Canada. ruth.lanius@lhsc.on.ca
authors.forename: R A
authors.initials: RA
authors.lastname: Lanius
authors.forename: P C
authors.initials: PC
authors.lastname: Williamson
authors.forename: M
authors.initials: M
authors.lastname: Densmore
authors.forename: K
authors.initials: K
authors.lastname: Boksman
authors.forename: M A
authors.initials: MA
authors.lastname: Gupta
authors.forename: R W
authors.initials: RW
authors.lastname: Neufeld
authors.forename: J S
authors.initials: JS
authors.lastname: Gati
authors.forename: R S
authors.initials: RS
authors.lastname: Menon
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000503:physiopathology*; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000453:epidemiology; D019263:Dysthymic Disorder / Q000453:epidemiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D016584:Panic Disorder / Q000453:epidemiology; D015995:Prevalence; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000453:epidemiology