The family of retinoblastoma proteins.
Our understanding of how the retinoblastoma family members, pRB/p105, pRB2/p130, and pRBL1/p107, regulate cellular properties has progressed significantly. Mechanisms have been described regarding how these proteins utilize properties of additional factors, such as histone deacetylases, to negatively regulate transcription. More importantly, the retinoblastoma proteins have been integrated within multiple cellular pathways, and a complex view has emerged on how the individual members respond to various external and internal stimuli. pRB/p105 is best described in its biochemical properties as well as in the resulting cellular functions. Less is known about pRB2/p130 and pRBL1/p107, but an improved map of their individual as well as redundant functions has been drawn over the last years. In this review we describe general aspects of the properties and functions of the three retinoblastoma family members and their protein-binding partners in cellular growth control.
Stiegler
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Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107, USA.
Giordano
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A
D020816:Amino Acid Motifs; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001665:Binding Sites; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D016384:Consensus Sequence; D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000502:physiology; D050759:Cyclin-Dependent Kinase Inhibitor p21; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D004268:DNA-Binding Proteins; D019281:Dimerization; D050684:E2F Transcription Factors; D005786:Gene Expression Regulation / Q000502:physiology; D016161:Genes, Retinoblastoma; D019942:Genes, p16; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008869:Microtubule-Associated Proteins / Q000502:physiology; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics; D009687:Nuclear Proteins / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D010766:Phosphorylation; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D011506:Proteins; D016160:Retinoblastoma Protein / Q000502:physiology*; D050720:Retinoblastoma-Like Protein p107; D050717:Retinoblastoma-Like Protein p130; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
C493956:CDKN1A protein, human; C108573:CdkI-p30 protein, Cricetulus griseus; C493957:Cdkn1a protein, mouse; D018797:Cell Cycle Proteins; D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D018398:Homeodomain Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D011506:Proteins; C493844:RBL1 protein, human; C493837:RBL2 protein, human; C489485:Rbl1 protein, mouse; C493838:Rbl2 protein, mouse; D016160:Retinoblastoma Protein; D050720:Retinoblastoma-Like Protein p107; D050717:Retinoblastoma-Like Protein p130; D014157:Transcription Factors; D018844:Cyclin-Dependent Kinases