title: Stereoselective Synthesis of a Key Precursor of Halicholactone and Neohalicholactone.
abstract: An efficient synthesis of a known precursor of halicholactone (1a) and neohalicholactone (1b) has been developed using the strategically functionalized key cyclopropane intermediate 2, which in turn has been synthesized via stereoselective cyclopropanation of trans-cinnamyl alcohol in the presence of the chiral dioxaborolane ligand 4. Elaboration of the above bifunctional cyclopropane to the target molecule was achieved in a relatively short reaction sequence and in good overall yield, representing a formal synthesis of the title compounds.
authors.affiliation: Organic III, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
authors.forename: Debendra K.
authors.initials: DK
authors.lastname: Mohapatra
authors.forename: Apurba
authors.initials: A
authors.lastname: Datta