title: Primary large cell neuroendocrine carcinoma of the presacral region.
abstract: A 7 cm diameter presacral tumour, not related to the intrapelvic organs, was found in a 51 year old woman. The needle biopsy showed a poorly differentiated large cell carcinoma. The patient died of urosepsis after chemotherapy. Postmortem examination revealed no other primary or metastatic tumour. Histological examination of the presacral tumour showed a large cell carcinoma with a trabecular pattern and strong immunoreactivity for neuroendocrine markers. The tumour was finally classified as a primary large cell neuroendocrine carcinoma of the presacral region.
authors.affiliation: Department of Pathology, Atrium Medical Centre, PO Box 4446, 6401CX Heerlen, The Netherlands. p.theunissen@gozl.nl
authors.forename: P
authors.initials: P
authors.lastname: Theunissen
authors.forename: M
authors.initials: M
authors.lastname: Fickers
authors.forename: R
authors.initials: R
authors.lastname: Goei
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018287:Carcinoma, Large Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D012447:Sacrum
chemical_list: D005047:Etoposide; D002945:Cisplatin