Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa.
A new pyrroloiminoquinone alkaloid (1) belonging to the makaluvamine family has been isolated from the sponge Zyzzya cf. fuliginosa collected in the waters off the Vanuatu Islands. The compound, designated makulavamine P, was characterized on the basis of its spectral data and displayed cytoxicity in the microM range on KB cells and antioxidant activity.
Casapullo
A
A
Dipartimento di Scienze Farmaceutiche, Università di Salerno, 84084 Fisciano (SA), Italy.
Cutignano
A
A
Bruno
I
I
Bifulco
G
G
Debitus
C
C
Gomez-Paloma
L
L
Riccio
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009303:Nasopharyngeal Neoplasms; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018675:Toxicity Tests; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011758:Pyrroles; D015363:Quinolones; C440948:makaluvamine P; D014969:Xanthine Oxidase