title: [Alternative bone replacement substances for preoperative design of individual CAD/CAM skull implants].
abstract: BACKGROUND
  The preoperative manufacturing of individual skull implants using computer aided design (CAD) and computer aided manufacturing (CAM) is based on the use of titanium, although the use of other materials is also potentially possible.
  The use of poly-(D,L-lactide) (PDLLA) as an implant material was investigated using an adult, formalin fixed sheep's head with a complex frontolateral defect. A standard individual titanium implant as well as a resection template made of aluminium were milled in order to allow bone resection and reconstruction within one operation. A mould was made of Teflon for the fabrication of the PDLLA implant using carbon dioxide at high pressure. This procedure allowed a critical comparison to be made of both implant materials and showed that the production of a biodegradable PDLLA implant is possible. At present the titanium implant is superior to the PDLLA implant, as PDLLA settled with slightly larger dimensions than the mould, although the structure itself was exact.
  
  
  CONCLUSIONS
  The goal of the present research is the fabrication of a functionally graded material made of polylactide, polyglycolide, calcium phosphate and osteoinductive proteins using existing technology, which will meet all of the requirements for stability, resorption kinetics, biocompatibility, radiotranslucence and osteogenic potency of an ideal implant material.
authors.affiliation: Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Universitätsklinikum, Ruhr-Universität Bochum, In der Schornau 23-25, 44892 Bochum. stephan.weihe@ruhr-uni-bochum.de
authors.forename: S
authors.initials: S
authors.lastname: Weihe
authors.forename: M
authors.initials: M
authors.lastname: Wehmöller
authors.forename: A
authors.initials: A
authors.lastname: Tschakaloff
authors.forename: R
authors.initials: R
authors.lastname: von Oepen
authors.forename: C
authors.initials: C
authors.lastname: Schiller
authors.forename: M
authors.initials: M
authors.lastname: Epple
authors.forename: H
authors.initials: H
authors.lastname: Eufinger
mesh_terms: D018786:Bone Substitutes; D017076:Computer-Aided Design; D003399:Craniotomy; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011474:Prosthesis Design; D017755:Prosthesis Fitting; D019919:Prosthesis Implantation; D014025:Titanium
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C033616:poly(lactide); D014025:Titanium