title: Synthesis of C-Glycosyl Lactones and Protected C-Glycosyl Amino Acids: Use of Radical Cyclization.
abstract: Protected carbohydrates 6a-13a, having one free hydroxyl and a phenylseleno group or halogen on the adjacent carbon, were condensed with (2,2-diphenylhydrazono)acetic acid (2); the resulting esters undergo radical cyclization to afford carbohydrates fused to a 2,2-diphenylhydrazino lactone unit (6c,d-13c,d). In suitable cases (9c,d) such carbohydrate lactones can be elaborated into C-glycosyl amino acids.
authors.affiliation: Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.
authors.forename: Junhu
authors.initials: J
authors.lastname: Zhang
authors.forename: Derrick L. J.
authors.initials: DL
authors.lastname: Clive