title: Incidence and predictors of PEG placement in ALS/MND.
abstract: In the Project on Death in America ALS cohort, 121 patients were followed to examine the timing of key milestones in the course of the disease, such as tracheostomy and PEG placement. During the 2- to 4-year follow-up period, 26.5% of patients received PEG, yielding a cumulative incidence of 48%. PEG placement occurred, on average, 16 months after patients received confirmation of the diagnosis at our Center. Patients who received PEG were more likely to have tracheostomies than patients not using PEG (p<0.01). In multivariate proportional hazard models that included both sociodemographic and disease indicators, the strongest predictor of PEG use was a patient's baseline preference for PEG: 57.1% of patients "absolutely in favor" went on to have PEG, compared to only 9.3% of those "absolutely against" (p<0.01). PEG users were more likely to have initiated health care proxies. These findings suggest that patients who use PEG may be consistently proactive in the face of the disease.
authors.affiliation: Eleanor and Lou Gehrig MDA/ALS Center, Neurological Institute, Columbia University, New York, NY, USA. sma10@columbia.edu
authors.forename: S M
authors.initials: SM
authors.lastname: Albert
authors.forename: P L
authors.initials: PL
authors.lastname: Murphy
authors.forename: M
authors.initials: M
authors.lastname: Del Bene
authors.forename: L P
authors.initials: LP
authors.lastname: Rowland
authors.forename: H
authors.initials: H
authors.lastname: Mitsumoto
mesh_terms: D001294:Attitude to Health; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005774:Gastrostomy / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000401:mortality / Q000601:surgery*; D015999:Multivariate Analysis; D010166:Palliative Care / Q000379:methods / Q000706:statistics & numerical data*; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D015996:Survival Rate; D014139:Tracheostomy / Q000706:statistics & numerical data; D014481:United States