title: The integration of high throughput technologies for drug discovery.
abstract: Producing quality clinical candidates less prone to late stage failure is greatly facilitated by better integration of the relevant high throughput functions and the inclusion of ADME/toxicology further upstream in the discovery process. We describe the tasks and their integration in the context of the design, make and test triad.
authors.affiliation: Discovery Partners International, San Diego, CA 92121, USA. greg.sabbatini@discovery-tech.com
authors.forename: G P
authors.initials: GP
authors.lastname: Sabbatini
authors.forename: W A
authors.initials: WA
authors.lastname: Shirley
authors.forename: D L
authors.initials: DL
authors.lastname: Coffen
mesh_terms: D001331:Automation; D020650:Combinatorial Chemistry Techniques; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D008958:Models, Molecular
chemical_list: D003577:Cytochrome P-450 Enzyme System