Expression of a novel protein by regenerating hepatocytes and peripheral blood lymphocytes.
Regeneration and tolerance factor (RTF) is a protein with immunosuppressive activity and is normally present in the thymus and placenta. RTF was measured in the livers of patients with regenerating nodules due to alcoholic cirrhosis and hepatitis C. RTF was expressed in the regenerating nodules of 26 patients with alcoholic cirrhosis. All patients with chronic hepatitis C without cirrhosis failed to express RTF. Flow cytometry revealed upregulation of RTF on the lymphocytes from alcoholic cirrhosis and downregulation in hepatitis C disease.
Chedid
A
A
Department of Pathology, Finch University of Health Sciences/Chicago Medical School and Veterans Affairs Medical Center, North Chicago, Illinois 60064, USA.
Sung
C C
CC
Lepe
M R
MR
Ahmed
S A
SA
Iftikhar
S A
SA
Feller
A
A
Beaman
K D
KD
D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000032:analysis; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis; D019698:Hepatitis C, Chronic / Q000276:immunology / Q000378:metabolism; D022781:Hepatocytes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology* / Q000378:metabolism*; D008562:Membrane Glycoproteins; D009244:NAD+ Nucleosidase / Q000032:analysis; D011257:Pregnancy Proteins / Q000032:analysis / Q000096:biosynthesis*; D013491:Suppressor Factors, Immunologic / Q000032:analysis / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000737:chemistry / Q000378:metabolism*; D006180:Proton-Translocating ATPases
D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD; D000943:Antigens, Differentiation; D006684:HLA-DR Antigens; D008562:Membrane Glycoproteins; D009244:NAD+ Nucleosidase; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; C498154:CD38 protein, human; C525845:ATP6V0A2 protein, human; D006180:Proton-Translocating ATPases