title: Using Serial Analysis of Gene Expression to identify tumor markers and antigens.
abstract: Tumor markers and antigens are normally highly expressed in malignant tissue, but not in the surrounding normal tissue. Serial Analysis of Gene Expression (SAGE) is a technology that counts mRNA transcripts and can be used to find those genes most highly induced in malignant tissues. SAGE produces a comprehensive profile of gene expression and can be used to search for tumor biomarkers in a limited number of samples. Public sources of SAGE data, in particular through the Cancer Genome Anatomy Project, increase the value of this technology by making a large source of information on many tumors and normal tissues available for comparison. Although the perfect tumor-specific gene does not exist, the differences in gene expression between tumor and normal can be exploited for therapeutic or diagnostic purposes.
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA. greg.riggins@duke.edu
authors.forename: G J
authors.initials: GJ
authors.lastname: Riggins
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D019295:Computational Biology; D020869:Gene Expression Profiling / Q000379:methods* / Q000639:trends; D006801:Humans
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor