title: Solitary fibrous tumor of the thyroid gland: report of seven cases.
abstract: Solitary fibrous tumor is a soft tissue neoplasm initially described in the pleura but subsequently reported in a wide variety of locations. The clinical behavior is usually benign, but the existence of aggressive cases has been documented both in the pleura and in extrapleural sites. In this report clinical and pathologic features of seven solitary fibrous tumors of the thyroid gland are presented. Patients' ages ranged from 43 to 64 years (mean 52 years), and tumor sizes varied from 2 to 6 cm. Grossly, the tumors were white-tan and well circumscribed. Microscopically, there was a variegated, wavy, storiform, hemangiopericytic or desmoid-like arrangement of spindle cells. Trapped thyroid follicles within the tumor and peripheral jagged tumor infiltration among follicles were common. There was immunohistochemical reactivity for CD34, CD99, and bcl-2, and ultrastructural analysis of one tumor was consistent with a fibroblastic lineage. The differential diagnosis included other benign and malignant mesenchymal tumors of the thyroid, spindle cell follicular adenoma, Riedel's thyroiditis, the spindle cell, and paucicellular variants of anaplastic carcinoma, papillary thyroid carcinoma with exuberant nodular fasciitis-like stroma, and the spindle epithelial tumor with thymus-like differentiation. The cumulative data of 13 cases (comprised of the seven present cases and the six previously reported) suggest a benign clinical behavior for thyroid SFT.
authors.affiliation: Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Rodriguez
authors.forename: E
authors.initials: E
authors.lastname: Ayala
authors.forename: C
authors.initials: C
authors.lastname: Caballero
authors.forename: C
authors.initials: C
authors.lastname: De Miguel
authors.forename: X
authors.initials: X
authors.lastname: Matias-Guiu
authors.forename: A L
authors.initials: AL
authors.lastname: Cubilla
authors.forename: J
authors.initials: J
authors.lastname: Rosai
mesh_terms: D000071443:12E7 Antigen; D000236:Adenoma / Q000175:diagnosis; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis; D002291:Carcinoma, Papillary / Q000175:diagnosis; D015815:Cell Adhesion Molecules / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008637:Mesenchymoma / Q000175:diagnosis; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000737:chemistry / Q000473:pathology*; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology*; D013966:Thyroiditis / Q000175:diagnosis
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D018952:Antigens, CD34; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D019253:Proto-Oncogene Proteins c-bcl-2