title: Wearing a noseclip improves nebulised aerosol delivery.
abstract: OBJECTIVE
  The efficiency of nebulised aerosol delivery is limited due to drug retained within the nebuliser, and due to a poor ratio between inspiratory drug delivery and expiratory drug loss. Several technical approaches have improved the ratio between inspiratory aerosol delivery and expiratory aerosol loss. In our pilot study we aimed to investigate if wearing a noseclip during inhalation therapy improves the inspiratory versus expiratory ratio and hence, improves nebulised aerosol delivery.
  
  
  METHODS
  Drug delivery was measured in thirteen subjects (7 males; age range 23-36 years) inhaling in random order nebulised aerosol through a mouthpiece once while wearing a noseclip and once without.
  
  
  RESULTS
  Wearing a noseclip leads to an increase of 113% (SEM 23.5) in drug delivery and improves the inspiratory versus expiratory ratio (ratio 2.07 versus 0.75).
  
  
  CONCLUSIONS
  We have shown that aerosol delivery is increased due to an improved inspiratory versus expiratory ratio when wearing a noseclip.
authors.affiliation: Swiss Paediatric Respiratory Physiology Research Group, Department of Respiratory Medicine, University Children's Hospital, Zürich.
authors.forename: R
authors.initials: R
authors.lastname: Meier
authors.forename: G L
authors.initials: GL
authors.lastname: Hall
authors.forename: F H
authors.initials: FH
authors.lastname: Sennhauser
authors.forename: J H
authors.initials: JH
authors.lastname: Wildhaber
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols / Q000008:administration & dosage* / Q000627:therapeutic use; D000420:Albuterol / Q000008:administration & dosage* / Q000627:therapeutic use; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D008297:Male; D009296:Nasal Cavity / Q000502:physiology; D009330:Nebulizers and Vaporizers; D009666:Nose; D013525:Surgical Instruments; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D000420:Albuterol