title: Emerging perspectives on lipid management: international approaches and global challenges.
abstract: The rapid growth in the understanding of the relation between cholesterol and coronary heart disease has introduced new challenges to the contemporary management of lipid disorders. The publication of the trials of the 3-hydroxy-3-methylglutaryl coenzyme-A inhibitors (statins) has invigorated support for the lipid hypothesis, and many advances have been made in understanding the mechanisms underlying atherosclerosis and the potential benefits of the statins. Several international groups have issued guidelines about desirable and undesirable lipid values to help clinical decision making. Despite the availability of such principles, there are many challenges to optimal management of lipid disorders.
authors.forename: A M
authors.initials: AM
authors.lastname: Gotto
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy*; D014943:Global Health; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D008074:Lipoproteins / Q000097:blood*; D017410:Practice Guidelines as Topic
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008074:Lipoproteins; D002097:C-Reactive Protein