The interplay between Mad and Myc in proliferation and differentiation.
Members of the Myc family of transcription factors are key regulators of cell proliferation, and excessive levels of Myc lead to tumor formation. Mad family proteins are related to Myc, but they antagonize the oncogenic activity of Myc in cell-culture assays. Here, we examine current models of Mad function and the relationship between Mad and Myc in cell proliferation, differentiation and tumorigenesis.
Zhou
Z Q
ZQ
Shriners Hospitals for Children, Department of Cell and Developmental Biology, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, OR 97201, USA. pjh@shcc.org
Hurlin
P J
PJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D008954:Models, Biological; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D012097:Repressor Proteins
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C079439:MXD1 protein, human; D016271:Proto-Oncogene Proteins c-myc; D012097:Repressor Proteins; D004247:DNA