title: [A case of cephalic tetanus presenting with opisthotonus].
abstract: We report a case of cephalic tetanus presenting with opisthotonus. A 49-year-old man was admitted because of repeated convulsions. The patient was a garbage truck driver known to be alcoholic, who fell down to suffer an injury of the left face two days before the onset of convulsion. Intravenous administration of diazepam and phenytoin partially relieved the convulsions. Anti-tetanus human immuno-globulin was also administered despite absence of typical clinical sign. Six hours later, however, the patient became unable to open the mouth, i.e. lockjaw developed, and the diagnosis of tetanus was made. Additional anti-tetanus human immunoglobulin of 3,000 units and 4,500 units on the next day rapidly relieved the lockjaw, convulsion, and general muscle rigidity without sequalae. The patient showed transient bilateral facial palsy and rotatory nystagmus during the course. Cephalic tetaus is characterized by a history of an injury of the head and a short latency before developing generalized tonic convulsion or opisthotonus. While a typical case presents with lockjaw, our case presented with opisthotonus, presumably because of early systemic lymphatic spreading of tetanus toxin. Early diagnosis and treatment is important to prevent generalized convulsions which are more frequent and sometimes lethal in cephalic tetanus than the common form.
authors.affiliation: Third Division, Department of Medicine, Kobe University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Nakazawa
authors.forename: F
authors.initials: F
authors.lastname: Kanda
authors.forename: H
authors.initials: H
authors.lastname: Ishihara
authors.forename: T
authors.initials: T
authors.lastname: Matsushita
authors.forename: K
authors.initials: K
authors.lastname: Chihara
mesh_terms: D005151:Facial Injuries / Q000150:complications; D005158:Facial Paralysis / Q000209:etiology / Q000628:therapy; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D008875:Middle Aged; D013742:Tetanus / Q000150:complications* / Q000628:therapy; D013743:Tetanus Antitoxin / Q000008:administration & dosage; D014313:Trismus / Q000209:etiology* / Q000628:therapy
chemical_list: D013743:Tetanus Antitoxin