Total Synthesis of (-)-Reserpine Using the Chiron Approach.
A highly stereocontrolled synthesis of ring D/E precursor to reserpine has been developed starting from (-)-quinic acid as a chiral template. The total synthesis of (-)-reserpine is described through the cyclization of an immonium lactam intermediate.
Hanessian
Stephen
S
Department of Chemistry, Université de Montréal, P. O. Box 6128, Station Centreville, Montréal, QC, Canada H3C 3J7.
Pan
Jingwen
J
Carnell
Andrew
A
Bouchard
Hervé
H
Lesage
Luc
L