Levels of transcription factors AP-2alpha and AP-2beta in the brainstem are correlated to monoamine turnover in the rat forebrain.
The transcription factors AP-2alpha and AP-2beta are implicated to play an important role during embryonic development of different parts of the brain, and in targeted regulation of gene expression in the adult brain. Several monoaminergic genes have binding sites for AP-2 in regulatory regions. We have in the present study, analysed the association between AP-2 levels in the brainstem of rats (n=9) and monoamine levels in the frontal cortex, septum and hippocampus. Several regionally specific correlations were found between AP-2alpha and AP-2beta and specific monoamines in the rat forebrain. The data support our notion that the transcription factor AP-2 family is involved in the regulation of the monoaminergic systems and, therefore, might be involved in the pathophysiology of neuropsychiatric disorders.
Damberg
M
M
Department of Neuroscience, Section of Pharmacology, Uppsala University, S-751 24 Uppsala, Sweden.
Eller
M
M
Tõnissaar
M
M
Oreland
L
L
Harro
J
J
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001933:Brain Stem / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000032:analysis / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D016548:Prosencephalon / Q000378:metabolism*; D051381:Rats; D020665:Septum of Brain / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000032:analysis / Q000378:metabolism*
D015306:Biogenic Monoamines; D004268:DNA-Binding Proteins; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine