title: Angiosarcoma of the breast: report of a case and its findings of MRI.
abstract: A 67-year-old woman with angiosarcoma of the left breast is presented. Physical findings showed a hard mass in the left breast with skin discoloration and erythema. Mammography showed a high density shadow in the mass without microcalcification and spicula. On ultrasonography, a hypoechoic mass with an ill-defined boundary was detected. On MRI, the tumor had low signal intensity on T1-weighted images, and higher signal intensity on T2-weighted images. MRI with Gd-DTPA images showed higher signal intensity on T1-weighted images with relatively lower intensity in the central area of the tumor. The artery supplying the tumor derived from the left inner thoracic artery and was visualized on three-dimensional dynamic MRI angiography. Initially misdiagnosed as inflammatory breast cancer, an arterial injection of CPA (100 mg) and 5-FU (500 mg) had been performed preoperatively. The definitive diagnosis of angiosarcoma was established by intraoperative frozen section examination. She underwent modified radical mastectomy and is now free of recurrence. This case emphasizes the difficulties in the clinical diagnosis of angiosarcoma of the breast.
authors.affiliation: Second Department of Surgery, Saitama Medical School, 38 Morohongo, Moroyama-machi, Iruma-gunn, Saitama 350-0495, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Murakam
authors.forename: H
authors.initials: H
authors.lastname: Nagano
authors.forename: K
authors.initials: K
authors.lastname: Okubo
authors.forename: H
authors.initials: H
authors.lastname: Sakata
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuji
authors.forename: T
authors.initials: T
authors.lastname: Ishiguro
authors.forename: R
authors.initials: R
authors.lastname: Hirayama
authors.forename: M
authors.initials: M
authors.lastname: Amanuma
authors.forename: T
authors.initials: T
authors.lastname: Hirose
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006394:Hemangiosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D018810:Magnetic Resonance Angiography; D008327:Mammography