New phenylpropanoid esters of sucrose from Polygonum lapathifolium.
Four new phenylpropanoid esters of sucrose, lapathosides A (1), B (2), C (3), and D (4), were isolated from the aerial parts of Polygonum lapathifolium together with known esters, vanicoside B (5) and hydropiperoside (6). The structures of 1-4 were determined by spectral (1D and 2D NMR and MS) analysis. Lapathoside A (1) and vanicoside B (2) showed significant inhibitory effects on the Epstein-Barr virus early antigen activation by tumor-promoters.
Takasaki
M
M
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.
Kuroki
S
S
Kozuka
M
M
Konoshima
T
T
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects* / Q000502:physiology; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019309:Epstein-Barr Virus Nuclear Antigens / Q000187:drug effects* / Q000502:physiology; D004952:Esters / Q000737:chemistry*; D006801:Humans; D016393:Lymphoma, B-Cell; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008516:Medicine, Chinese Traditional; D020030:Nitric Oxide Donors / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D028502:Polygonum / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013395:Sucrose / Q000031:analogs & derivatives* / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014775:Virus Activation / Q000187:drug effects
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D002934:Cinnamates; D004187:Disaccharides; D019309:Epstein-Barr Virus Nuclear Antigens; D004952:Esters; D020030:Nitric Oxide Donors; C440672:hydropiperoside; C440098:lapathoside A; C440669:lapathoside B; C440670:lapathoside C; C440671:lapathoside D; C087106:vanicoside B; D013395:Sucrose