Dendritic cell-based therapy: a review focusing on antigenic selection.
Recently, technologies have developed that allow for the culturing of antigen-presenting cells (APC), such as dendritic cells (DC). The normal function of these cells is to present antigens to T cells, which then specifically recognize and ultimately eliminate the antigen source. Over the past number of years, these cells have been used in a variety of different immunotherapeutic strategies. Paramount in the success of such endeavors is the generation of desired T cell responses through the selection of appropriate antigens. This paper will serve to discuss the development and current status of dendritic cell-based therapy focusing on antigen selection for cancer.
Syme
R M
RM
Department of Oncology, Medicine, Faculty of Medicine, University of Calgary, Tom Baker Cancer Centre, Calgary AB, Canada.
Bryan
T L
TL
Glück
S
S
D000941:Antigens / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy
D000941:Antigens; D019496:Cancer Vaccines