title: Stereoselective Modification of a Cyclopentapeptide via an alpha-(Ethylthio)glycine Residue.
abstract: The solid-phase synthesis of cyclo[Val-D-Gly(SEt)-Pro-Phe-D-Ala] (5) on Kaiser's oxime resin is described. Conversion of 5 to the reactive alpha-chloroglycine derivative 9 allowed the stereoselective addition of thiols, alcohols, amines and other nucleophiles with formation of the modified cyclopeptides 11a-n.
authors.affiliation: Institut für Organische Chemie der Universität München Karlstrasse 23, D-80333 München, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Paulitz
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Steglich