Neuromodulatory effects of serotonin antibodies on behavioral responses, neurotransmitter content in the central nervous system, and ligand-binding activity of central serotonin receptors in C57BL/6 and BALB/c mice.
Effects of active immunization with the serotonin-protein conjugate on open-field behavior, learning and retention of the conditioned passive avoidance response, neurotransmitter contents in brain structures, and functional activity of central serotonin receptors were studied on C57Bl/6 and BALB/c mice. Serotonin antibodies produced opposite effects on the studied parameters in genetically different mouse strains.
Evseev
V A
VA
Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences.
Trekova
N A
NA
Vetrile
L A
LA
Mikovskaya
O I
OI
Basharova
L A
LA
Gruden'
M A
MA
Khlopushina
T G
TG
D000818:Animals; D000906:Antibodies / Q000378:metabolism; D001362:Avoidance Learning; D001522:Behavior, Animal; D001921:Brain / Q000378:metabolism*; D003213:Conditioning, Psychological; D006801:Humans; D007114:Immunization; D008024:Ligands; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D015213:Neuroimmunomodulation; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011485:Protein Binding; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000276:immunology* / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000276:immunology*
D000906:Antibodies; D008024:Ligands; D018377:Neurotransmitter Agents; D011985:Receptors, Serotonin; C101227:serotonin-BSA conjugate; D012710:Serum Albumin, Bovine; D012701:Serotonin