Fish oil supplementation improves visual evoked potentials in children with phenylketonuria.
Visual evoked potentials (VEP) were measured in 36 patients with early-treated phenylketonuria (PKU; aged 1 to 11 years) and good metabolic control before and after supplementation with omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) from fish oil. Patients with PKU had significantly longer P100 latencies than 22 age-matched control subjects. After 3 months of LC-PUFA supplementation, VEP latencies improved significantly in PKU patients but did not change in 12 untreated healthy children. The authors conclude that omega-3 LC-PUFA are essential substrates for nervous system function even beyond infancy.
Beblo
S
S
Division of Metabolic Diseases and Nutrition, Dr. von Haunersches Kinderspital, Munich, Germany.
Reinhardt
H
H
Muntau
A C
AC
Mueller-Felber
W
W
Roscher
A A
AA
Koletzko
B
B
D002648:Child; D002675:Child, Preschool; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D010661:Phenylketonurias / Q000188:drug therapy* / Q000503:physiopathology
D015525:Fatty Acids, Omega-3; D005395:Fish Oils