title: Role of muscular exercise in amyotrophic lateral sclerosis.
abstract: The general, systemic, and specific neuromuscular adaptation to physical exercise and training in healthy individuals is reviewed with application to individuals with neuromuscular disease in general and ALS in particular. A pilot study utilizing patients with ALS suggests the cardiopulmonary response to acute exercise is similar to normal individuals. However, a case study of a training response suggests the success of neuromuscular adaptation will be dependent upon the degree of motor neuron involvement.
authors.affiliation: Department of Neurology, University of Wisconsin Medical School, ALS Clinical Research Center, University of Wisconsin Hospital and Clinics, Madison 53792, USA.
authors.forename: M
authors.initials: M
authors.lastname: Sanjak
authors.forename: W
authors.initials: W
authors.lastname: Reddan
authors.forename: B R
authors.initials: BR
authors.lastname: Brooks
mesh_terms: D000328:Adult; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000503:physiopathology / Q000534:rehabilitation*; D009046:Motor Neurons / Q000502:physiology; D009121:Muscle Denervation / Q000534:rehabilitation; D010101:Oxygen Consumption / Q000502:physiology; D026741:Physical Therapy Modalities