Progress in the application of DNA microarrays.
Microarray technology has been applied to a variety of different fields to address fundamental research questions. The use of microarrays, or DNA chips, to study the gene expression profiles of biologic samples began in 1995. Since that time, the fundamental concepts behind the chip, the technology required for making and using these chips, and the multitude of statistical tools for analyzing the data have been extensively reviewed. For this reason, the focus of this review will be not on the technology itself but on the application of microarrays as a research tool and the future challenges of the field.
Lobenhofer
E K
EK
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Bushel
P R
PR
Afshari
C A
CA
Hamadeh
H K
HK
D004782:Environmental Health; D020869:Gene Expression Profiling; D006801:Humans; D007239:Infections; D008490:Medical Informatics; D009369:Neoplasms / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000639:trends*; D012107:Research Design