Application of automated flow injection analysis to drug liberations studies with the Franz diffusion cell.
The flow-injection method with sensitive fluorimetric detection is used to monitor the liberation profiles of a topical dermatological formulation containing the model compound salicylic acid. The connection of a standard Franz diffusion cell with the automated flow-injection system enables an acquisition of multi-point liberation data in a form of series of fluorescence peaks in a short time. Examples of liberation profiles for a topical dermatological formulation containing salicylic acid are shown.
Solich
P
P
Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic. solich@faf.cuni.cz
Ogrocká
E
E
Schaefer
U
U
D001322:Autoanalysis; D002138:Calibration; D004058:Diffusion; D017022:Flow Injection Analysis / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D009824:Ointments; D004364:Pharmaceutical Preparations / Q000032:analysis*; D020156:Salicylic Acid / Q000032:analysis; D013050:Spectrometry, Fluorescence
D009824:Ointments; D004364:Pharmaceutical Preparations; D020156:Salicylic Acid