title: Prevention of pathologies associated with oxidative stress and dietary intake deficiencies: folate deficiency and requirements.
abstract: Folate (folic acid, folacin) is an essential vitamin that is found in nature. Folates contain the core chemical structure of pteroylglutamic acid, but vary in their state of reduction, the single carbon moiety they bear and/or the length of the glutamate chain. At least 50% of whole body folate is stored in the liver. The influence of intracellular folate concentration depends largely on dietary intake. The supply of folate depends primarily on the quantity and bioavailability of ingested folate and the rate of loss by urinary and fecal routes and through catabolism.
authors.affiliation: Laboratoire de Pharmacologie Cellulaire et Moléculaire, CNRS UMR 8612, Université de Paris Sud, Faculté de Pharmacie, Chatenay Malabry, France. haimtapiero@aol.com
authors.forename: H
authors.initials: H
authors.lastname: Tapiero
authors.forename: K D
authors.initials: KD
authors.lastname: Tew
authors.forename: L
authors.initials: L
authors.lastname: Gaté
authors.forename: D
authors.initials: D
authors.lastname: Machover
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism; D004032:Diet; D005492:Folic Acid / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D005494:Folic Acid Deficiency / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D006710:Homocysteine / Q000378:metabolism / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D009369:Neoplasms / Q000209:etiology / Q000503:physiopathology; D009752:Nutritional Status; D018384:Oxidative Stress / Q000187:drug effects*; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D014498:Uracil / Q000378:metabolism
chemical_list: D006710:Homocysteine; D014498:Uracil; D004247:DNA; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase