title: Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster.
abstract: We studied the effects of Epithalon (Ala-Glu-Asp-Gly) and Vilon (Lys-Glu) on free radical processes in highly inbred HA(+)line of Drosophila melanogaster. Vilon inhibited generation of reactive oxygen species in mitochondria, but stimulated this process in the cytosol. We found sex- and age-related differences in the generation of reactive oxygen species and cytosol antioxidant activity.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences. vvm@medport.ru
authors.forename: V K
authors.initials: VK
authors.lastname: Khavinson
authors.forename: S V
authors.initials: SV
authors.lastname: Myl'nikov
authors.forename: T I
authors.initials: TI
authors.lastname: Oparina
authors.forename: A V
authors.initials: AV
authors.lastname: Arutyunyan
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002458:Cell Fractionation; D004151:Dipeptides / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D007814:Larva / Q000502:physiology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D004151:Dipeptides; D009842:Oligopeptides; D017382:Reactive Oxygen Species; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine