Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics.
Data concerning cytogenetic features of childhood ependymoma are rare. In this article, a gain of 1q was identified as the sole alteration in a primary childhood infratentorial ependymoma by comparative genomic hybridization (CGH). A recurrence of this brain tumor was studied using multiplex-fluorescence in situ hybridization (M-FISH) in addition to CGH and G-banding analysis. In accordance with the primary tumor, a gain of 1q corresponding to an isochromosome 1q was observed indicating an early event in the tumor development. Furthermore, M-FISH classified several other rearranged chromosomes including 6q and 17p that have previously been found to be involved in the development and progression of childhood ependymoma.
Granzow
M
M
Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany.
Popp
S
S
Weber
S
S
Schoell
B
B
Holtgreve-Grez
H
H
Senf
L
L
Hager
D
D
Boschert
J
J
Scheurlen
W
W
Jauch
A
A
D001932:Brain Neoplasms / Q000235:genetics*; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D004806:Ependymoma / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male