Solid-Phase Synthesis and Photophysical Properties of DNA Labeled at the Nucleobase with Ru(bpy)(2)(4-m-4'-pa-bpy)(2+).
A facile procedure for incorporating a Ru(diimine)(3)(2+) complex at the nucleobase in an oligonucleotide is reported that combines the advantages of Pd(0) cross-coupling and solid-phase DNA chemistries. These ruthenium-modified oligonucleotides form stable duplexes, and the favorable photophysical properties associated with the Ru(diimine)(3)(2+) complex are retained after site-specific covalent attachment.
Khan
Shoeb I.
SI
Paul M. Gross Chemical Laboratory, Department of Chemistry, Duke University, Durham, North Carolina 27708.
Beilstein
Amy E.
AE
Tierney
Mark T.
MT
Sykora
Milan
M
Grinstaff
Mark W.
MW