shibire's enhancer is cancer's suppressor.
Reliable neurotransmitter release requires an adequate pool of synaptic vesicles. These pools are maintained by the process of endocytosis. A recent paper revealed that dynamin, a GTPase essential for endocytosis, is regulated by Abnormal wing disc (Awd), a nucleoside diphosphate kinase which converts nucleoside diphosphates to nucleoside triphosphates. This finding suggests that access to GTP directly regulates endocytosis. In addition, awd is homologous to the tumor suppressor gene nm23, further suggesting that dynamin might be involved in tumorigenesis.
Deitcher
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Dept of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA. dld14@cornell.edu
D000818:Animals; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D034281:Dynamins; D004705:Endocytosis / Q000502:physiology; D004742:Enhancer Elements, Genetic / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000235:genetics* / Q000502:physiology; D016147:Genes, Tumor Suppressor; D019476:Insect Proteins / Q000502:physiology; D009701:Nucleoside-Diphosphate Kinase; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D014921:Wings, Animal / Q000002:abnormalities
D029721:Drosophila Proteins; D019476:Insect Proteins; D019269:Phosphatidylinositol 4,5-Diphosphate; D009701:Nucleoside-Diphosphate Kinase; C061642:awd protein, Drosophila; D020558:GTP Phosphohydrolases; D034281:Dynamins; C439628:shi protein, Drosophila