title: Hemorrhage in the oculomotor nerve as a complication of leukemia.
abstract: Oculomotor paralysis of a patient with leukemia was revealed at autopsy to be caused by a hemorrhage in the oculomotor nerve. In a 63-year-old woman with pre-B-cell acute lymphatic leukemia, leukemic invasions occurred in her spinal cord and right oculomotor nerve during a hematological remission state. The oculomotor palsy was aggravated to complete paralysis during a leukemic relapse, which lasted until her death. An autopsy revealed a hemorrhage along with leukemic cells in the right oculomotor nerve at the segment in the upper orbital fissure. Although hemorrhagic oculomotor paralysis is a very rare complication, reports of its occurrence will likely increase with improved survival times of leukemia patients due to advances in chemotherapy.
authors.affiliation: Third Department of Internal Medicine, Kobe University School of Medicine, Japan. jinnaike@hyougotyu.hosp.go.jp
authors.forename: K
authors.initials: K
authors.lastname: Jinnai
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D002574:Cervical Vertebrae; D005260:Female; D006680:HLA Antigens / Q000378:metabolism; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D017254:Leukemic Infiltration / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D009802:Oculomotor Nerve / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D015840:Oculomotor Nerve Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012008:Recurrence; D013116:Spinal Cord / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D006680:HLA Antigens