Decomposition of bisphenol-A (BPA) by radical oxygen.
A change in bisphenol-A (BPA) concentration leached from polycarbonate (PC) tube to the phosphatidyl ethanolamine (PhE)-containing water was compared to water only. Time-dependent increase in BPA concentration was observed in both samples at 37 degrees C. The leaching velocity of BPA to water was three times faster than that to PhE-containing water and BPA concentration in water reached to 55.8 ng/ml 5 weeks later. When BPA was determined immediately after BPA addition of various concentration of PhE up to 2.5mg/ml to water, the BPA recoveries were over 93%. But, when incubated at 37 degrees C for a special time, BPA concentration in PhE-containing water in glass tube decreased time-dependently. In the presence of H2O2, time and Fe3+ dose-dependent decrease in the BPA concentration particularly, a drastic decrease above 0.44 mM Fe3+ was observed. These results suggest that BPA would be decomposed by radical oxygen including lipoperoxides. An addition of serum prevented BPA decrease from radical oxygen to a great extent but could not recover the BPA decrease. Thiobarbituric acid (TBA) value, a good parameter of lipid oxidation, decreased gradually in the mixture of H9O2 and Fe3+ in the presence of BPA, implying an inhibition of lipid oxidation due to BPA oxidation by radical oxygen.
Sajiki
J
J
The Public Health Laboratory of Chiba Prefecture, Chiba City, Japan. sajiki@beige.ocn.ne.jp
D001559:Benzhydryl Compounds; D002851:Chromatography, High Pressure Liquid; D017665:Hydroxyl Radical / Q000737:chemistry*; D007202:Indicators and Reagents; D010636:Phenols / Q000032:analysis*; D010714:Phosphatidylethanolamines; D010969:Plastics / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry*; D017392:Thiobarbituric Acid Reactive Substances; D013997:Time Factors; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D017665:Hydroxyl Radical; D007202:Indicators and Reagents; D010636:Phenols; D010714:Phosphatidylethanolamines; D010969:Plastics; D011108:Polymers; D013481:Superoxides; D017392:Thiobarbituric Acid Reactive Substances; C017902:lexan; C006780:bisphenol A; D000098826:Bisphenol A Compounds