Expression of vesl-1S/homer-1a, a gene associated with long-term potentiation, in the brain of the epileptic EI mouse.
The El mouse is an animal model for hereditary epilepsy. It undergoes a convulsive seizure lasting 10-30 s after vestibular stimulation, such as "tossing-up". To better characterize the effects of seizure activity in the El mouse, we examined the expression profile of vesl-1S/homer-1a mRNA in the brain. It has been shown that this mRNA is expressed after long-term potentiation or seizures induced by electrical or pharmacological stimulations. The basal level of vesl-1S mRNA was very low even in seizure-susceptible El mice. The El mouse hippocampus, but not that of ddY mice, showed a remarkable increase in vesl-1S mRNA expression in the dentate granule cell layer after seizure induced by "tossing-up". The mRNA remained for about 3 h after the seizure and disappeared after 8 h.
Morioka
R
R
Department of Biology, Faculty of Science, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
Kato
A
A
Fueta
Y
Y
Sugiyama
H
H
D000818:Animals; D001923:Brain Chemistry / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D004827:Epilepsy / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D015870:Gene Expression; D017781:Genes, Immediate-Early / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology; D000072233:Homer Scaffolding Proteins; D017403:In Situ Hybridization; D017774:Long-Term Potentiation / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D009479:Neuropeptides / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis
D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D009479:Neuropeptides; D012333:RNA, Messenger