Cell cycle: Waiters serving the Destruction machinery.
Targeting regulatory proteins for destruction, and thereby controlling progression through mitosis, is the crucial task for the anaphase-promoting complex (APC). Recent evidence suggests that essential APC activators, WD40 repeat proteins of the Cdc20 family, act as long-suspected receptors for APC substrates.
Vodermaier
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HC
Research Institute of Molecular Pathology, Dr.Bohr-Gasse 7, A-1030, Vienna, Austria. vodermaier@nt.imp.univie.ac.at
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002352:Carrier Proteins; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins; D005656:Fungal Proteins / Q000378:metabolism*; D015801:Helminth Proteins / Q000378:metabolism*; D008025:Ligases / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D009687:Nuclear Proteins; D010453:Peptide Synthases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D044843:SKP Cullin F-Box Protein Ligases; D043743:Ubiquitin-Protein Ligase Complexes; D044767:Ubiquitin-Protein Ligases; D015003:Yeasts / Q000166:cytology
D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D015801:Helminth Proteins; D009687:Nuclear Proteins; D011506:Proteins; C400683:che-2 protein, C elegans; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044843:SKP Cullin F-Box Protein Ligases; D044767:Ubiquitin-Protein Ligases; D008025:Ligases; D010453:Peptide Synthases