Effect of acidosis on contractile function of mesenterial lymphatic vessels in bulls.
Extracellular normocapnic acidosis inhibited spontaneous phasic contractile activity and reduced the tone of isolated bovine mesenterial lymphatic vessels. Acidosis induced dilation of lymphatic vessels due to activation of ATP-sensitive potassium channels in myocyte membrane and stimulation of NO production by endotheliocytes.
Lobov
G I
GI
Department of Normal Physiology, I. I. Mechnikov State Medical Academy, St. Petersburg. lobov@infran.ru
Kubyshkina
N A
NA
D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D017609:Barium Compounds / Q000494:pharmacology; D002417:Cattle; D002712:Chlorides / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008208:Lymphatic System / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008643:Mesentery; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*
D000889:Anti-Arrhythmia Agents; D017609:Barium Compounds; D002712:Chlorides; C024986:barium chloride; D005905:Glyburide