A preliminary study of angiogenesis in paediatric glioblastoma multiforme and its correlation with survival.
OBJECTIVE
There is a distinct challenge in bringing modern insights into glial tumour genesis to bear on improved outcomes for patients. Insights provided by neuroncological, neuroradiological, neuropathological, and neurosurgical investigations may offer significant advantages in the management of paediatric GBM. The goal of this study was to evaluate angiogenesis as a potential indicator of survival in paediatric glioblastoma multiforme (GBM).


METHODS
Angiogenesis was evaluated in six cases of paediatric GBM with multiple criteria, including contrast enhancement on preoperative CT scan, histological vascular hyperplasia (VH) and endothelial proliferation (EP) and immunohistochemical tenascin-C (TN-C) expression. We employed a semiquantitative scale, ranging from not detected (zero) to marked (+3), for each investigational parameter. We evaluated the influence of angiogenesis on survival in each case.


CONCLUSIONS
In this preliminary study, angiogenesis provided information that correlated with survival, albeit in a limited number of patients. As we gain better understanding of the molecular biology of brain tumours, with the multitude of genetic alterations and growth factors new therapeutic approaches may emerge, which may hold the promise for cure.
Germanò
A
A
Neurosurgical Clinic-Policlinico, University of Messina School of Medicine, Via Consolare Valeria, 1, 98125 Messina, Italy. germano@unime.it
Caffo
M
M
Caruso
G
G
La Rosa
G
G
Galatioto
S
S
Tomasello
F
F
D001932:Brain Neoplasms / Q000098:blood supply* / Q000737:chemistry / Q000401:mortality* / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005909:Glioblastoma / Q000098:blood supply* / Q000737:chemistry / Q000401:mortality* / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009389:Neovascularization, Pathologic; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D019063:Tenascin / Q000032:analysis; D016896:Treatment Outcome
D019063:Tenascin