[Toxicological characterization of a novel inductor of interferon, PK-43, synthesized on cotton cellulose].
Acute and subacute toxicity of a novel inductor of interferon [symbol: see text]-43 synthesized on the base of the cotton cellulose has been studied in white mice and rats. It has been established that a single administration of [symbol: see text]-43 even in a dose of 3000 mg/kg does not result in a death of mice. No apparent deviations were noted in the systemic condition and behavior of rats, in parameters for the peripheral blood and activity of transaminases with daily administration of the preparation over 30 days at doses 50,100 and 200 mg/kg. In addition, the drug does not have hepatotoxic and nephrotoxic effects. The derivatives of the cotton cellulose [symbol: see text]-43 are considered to be low toxic compounds.
Sarimsakov
A A
AA
Khakimov
E E
EE
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity*; D004334:Drug Administration Schedule; D003368:Gossypium / Q000737:chemistry; D007369:Interferon Inducers / Q000138:chemical synthesis / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D000637:Transaminases / Q000097:blood
D007369:Interferon Inducers; D002482:Cellulose; D000637:Transaminases