title: Coronary magnetic resonance angiography: experimental evaluation of the new rapid clearance blood pool contrast medium P792.
abstract: The signal-enhancing characteristics of a new monodisperse monogadolinated macromolecular MR contrast medium (P792) were evaluated for magnetic resonance angiography (MRA) of the coronary arteries. A total of 15 cardiac examinations were performed in pigs at 1.5 T using a 3D gradient-echo sequence. Images were acquired during breath-hold before and up to 35 min after IV injection of Gd-DTPA (0.3 mmol Gd/kg), Gd-BOPTA (0.2 mmol Gd/kg), and P792 (13 micromol Gd/kg). An increase in the signal-to-noise ratio (SNR) of 97% +/- 17%, 108% +/- 37%, and 109% +/- 31% in coronary arteries and of 82% +/- 19%, 82% +/- 24%, and 28% +/- 18% in myocardium, respectively, was measured during the first postcontrast acquisition. The blood-to-myocardium signal-difference-to-noise ratio (SDNR) was significantly higher for P792 than for the other Gd compounds (P <.05) for up to 15 min after injection. Qualitative assessment showed that visualization of the coronary arteries and their branches was significantly better for P792 compared to the low-molecular Gd compounds (P <.05). The blood pool contrast medium P792 is well suited for MRA of the coronary arteries.
authors.affiliation: Department of Radiology, Charité, Medizinische Fakultät, Humboldt-Universität zu Berlin, Berlin, Germany. matthias.taupitz@charite.de
authors.forename: M
authors.initials: M
authors.lastname: Taupitz
authors.forename: J
authors.initials: J
authors.lastname: Schnorr
authors.forename: S
authors.initials: S
authors.lastname: Wagner
authors.forename: D
authors.initials: D
authors.lastname: Kivelitz
authors.forename: P
authors.initials: P
authors.lastname: Rogalla
authors.forename: G
authors.initials: G
authors.lastname: Claassen
authors.forename: M
authors.initials: M
authors.lastname: Dewey
authors.forename: P
authors.initials: P
authors.lastname: Robert
authors.forename: C
authors.initials: C
authors.lastname: Corot
authors.forename: B
authors.initials: B
authors.lastname: Hamm
mesh_terms: D000818:Animals; D003287:Contrast Media; D003331:Coronary Vessels / Q000033:anatomy & histology*; D005682:Gadolinium; D019786:Gadolinium DTPA; D006571:Heterocyclic Compounds; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D013552:Swine; D013556:Swine, Miniature
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D005682:Gadolinium; D019786:Gadolinium DTPA; C435266:contrast agent P792