Synthesis and in vitro cytotoxicity of 4-alkyl- or 4-arylaminosubstituted cyclopenta[c]quinoline derivatives.
Twelve 4-substituted cyclopenta[c]quinoline derivatives were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The compounds 6c and 6e bearing p-anisidine and pyrrolidine side chain were more active than the others.
Lee
H
H
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea. medchem@trut.chungbuk.ac.kr
Lee
J
J
Yang
S I
SI
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D014407:Tumor Cells, Cultured
D000634:Aminoquinolines; D000970:Antineoplastic Agents; D006575:Heterocyclic Compounds, 3-Ring; D007202:Indicators and Reagents; D004247:DNA