[Effect of two extracted fraction from Lycopus lucidus on coagulation function].
OBJECTIVE
To find and define the effective fraction of Lycopus lucidus on coagulation.


METHODS
Method of comparing turbidity, method of cutting a part of the mice tail and method of breaking glass tube.


RESULTS
The two extracted fraction from lycopus lucidus F04-0A and F04-B could inhibit rats platlet aggregation in vitro and mice platelet aggregation in vivo. They could also prolong mice blood coagulation time. However, they had no effect on bleeding time.


CONCLUSIONS
Both F04-A and F04-B had effects on inhibiting platelet aggregation and blood coagulation. Moreover, the activity of F04-A was probably stronger than that of F04-B. F04-A may be the effective fraction from Lycopus lucidus on promoting blood circulation and removing blood stasis.
Tian
Z
Z
Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Beijing 100094.
Gao
N
N
Li
L
L
Yu
J
J
Luo
X
X
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018056:Hemorheology / Q000187:drug effects; D031333:Lycopus / Q000737:chemistry*; D008297:Male; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects*
D004365:Drugs, Chinese Herbal