Effects of solar radiation on cutaneous detoxification pathways.
Because of its accessibility the human skin is constantly exposed to solar ultraviolet (UV) radiation. It is increasingly appreciated that exposure of the mammalian skin to UV plays a causal and decisive role in acute and chronic skin damage including the development of skin cancer. UV exposure causes sunburn, pigmentation, hyperplasia, immunosuppression, DNA damage, photoaging and photocarcinogenesis. To cope with constant environmental damage the skin possesses elaborate enzymatic detoxification systems. This paper briefly focuses on the effect of solar radiation, particularly UV spectrum, on detoxification pathways in the skin. Specifically the effect of solar radiation on cytochrome P450, glutathione, superoxide dismutase, glutathione peroxidase, catalase, glutathione-S-transferase and ceruloplasmin has been discussed.
Afaq
F
F
Department of Dermatology, School of Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
Mukhtar
H
H
D000818:Animals; D004798:Enzymes / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D012867:Skin / Q000201:enzymology* / Q000528:radiation effects*; D019445:Solar Activity; D014466:Ultraviolet Rays / Q000009:adverse effects
D004798:Enzymes