Syntheses and activities as trehalase inhibitors of N-arylglycosylamines derived from fluorinated anilines.
Twelve N-arylglycosylamines were prepared in a one-pot reaction by treatment of D-glucose, D-galactose, D-mannose or D-xylose with fluorinated anilines in the presence of small amount of hydrochloric acid. The inhibitory activity against porcine trehalase and the fungicidal activity of the title compounds toward Rhizoctonia solani have been tested.
Qian
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State Key Laboratory of Fine Chemicals, Dalian University of Technology, 116012, Dalian, People's Republic of China. bottle_0@chinaren.com
Li
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Liu
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Song
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Li
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D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D005461:Fluorine / Q000737:chemistry; D005688:Galactosamine / Q000138:chemical synthesis / Q000494:pharmacology; D005944:Glucosamine / Q000138:chemical synthesis / Q000494:pharmacology; D006595:Hexosamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D012232:Rhizoctonia / Q000187:drug effects; D013329:Structure-Activity Relationship; D013552:Swine; D014198:Trehalase / Q000037:antagonists & inhibitors*; D014994:Xylose / Q000138:chemical synthesis / Q000494:pharmacology
D000814:Aniline Compounds; D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D006595:Hexosamines; C008322:mannosamine; D005461:Fluorine; D005688:Galactosamine; D014994:Xylose; D014198:Trehalase; D005944:Glucosamine