title: A simple resolution procedure using the Staudinger reaction for the preparation of P-stereogenic phosphine oxides.
abstract: The resolution of a variety of (+/-)-P-stereogenic phosphines is achieved by exploiting the Staudinger reaction of a (+/-)-phosphine with enantiopure (1S,2R)-O-(tert-butyldimethylsilyl)isobornyl-10-sulfonyl azide. The resulting mixtures of diastereomeric phosphinimines are generally separable by fractional crystallization or flash chromatography. Subsequent acid-catalyzed hydrolysis provides the corresponding optically pure phosphine oxides in high yields.
authors.affiliation: Department of Chemistry, University of Calgary, Calgary, AB, Canada, T2N 1N4.
authors.forename: N G
authors.initials: NG
authors.lastname: Andersen
authors.forename: P D
authors.initials: PD
authors.lastname: Ramsden
authors.forename: D
authors.initials: D
authors.lastname: Che
authors.forename: M
authors.initials: M
authors.lastname: Parvez
authors.forename: B A
authors.initials: BA
authors.lastname: Keay