Epstein-Barr virus complementary strand transcripts (CSTs/BARTs) and cancer.
Epstein-Barr virus (EBV) encodes a family of related transcripts, the complementary strand transcripts (CSTs) or BARTs (Bam A rightward transcripts). These are present in all types of EBV infection but are expressed to particularly high levels in nasopharyngeal carcinomas. Although convincing demonstration of protein expression from these transcripts is still subject to some debate, potential proteins encoded by them have been shown to modify Notch signalling pathways.
Smith
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Institute for Cancer Genetics and Pharmacogenomics, Department of Biology, Brunel University, Uxbridge, UB8 3PH, UK. p.r.smith@brunel.ac.uk
D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D009303:Nasopharyngeal Neoplasms / Q000821:virology*; D009363:Neoplasm Proteins; D009690:Nucleic Acid Conformation; D016366:Open Reading Frames / Q000235:genetics; D018075:RNA, Complementary / Q000737:chemistry / Q000235:genetics*; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D051880:Receptors, Notch; D014158:Transcription, Genetic / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
D008565:Membrane Proteins; D009363:Neoplasm Proteins; D018075:RNA, Complementary; D012367:RNA, Viral; C423082:RPMS protein, Human herpesvirus 4; D051880:Receptors, Notch; D014764:Viral Proteins