Cellular senescence as a tumor-suppressor mechanism.
Organisms with renewable tissues had to evolve mechanisms to prevent the development of cancer. One such mechanism is cellular senescence, which irreversibly arrests the growth of cells at risk for neoplastic transformation. Recent findings have revealed the complexities of the senescence phenotype and unexpected possible consequences for the organism.
Campisi
J
J
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA. jcampisi@lbl.gov
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000503:physiopathology; D010641:Phenotype; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000378:metabolism
D016160:Retinoblastoma Protein