Insulin signaling: lessons from the Drosophila tuberous sclerosis complex, a tumor suppressor.
The genes that encode the proteins composing the tuberous sclerosis complex (TSC) are tumor suppressors. Experiments in the model organism Drosophila melanogaster have provided insight into the identity of these genes and their functions in regulating cell size and proliferation. Montagne et al. describe the various genetic interactions that show TSC to be a regulator of the insulin signaling pathway and a regulator of progression through the cell cycle, which explains its effects on cell size and tissue and tumor growth.
Montagne
J
J
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66 Basel, CH-4058, Switzerland.
Radimerski
T
T
Thomas
G
G
D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D006131:Growth Inhibitors / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000502:physiology*; D008957:Models, Genetic; D012097:Repressor Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*; D014402:Tuberous Sclerosis / Q000235:genetics* / Q000473:pathology; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins
D006131:Growth Inhibitors; D007328:Insulin; D012097:Repressor Proteins; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins