title: Cell biology. Fusion without SNAREs?
abstract: Highly orchestrated molecular rearrangements are required for two membranes to fuse, as happens, for example, during neurotransmitter release into the synapse. In an elegant Perspective, Scales et al. discuss two studies (Schoch et al., Wang et al.) that shed new light on the protein interactions involved in membrane fusion.
authors.affiliation: Genentech Inc., South San Francisco, CA 94080, USA. sscales@gene.com
authors.forename: S J
authors.initials: SJ
authors.lastname: Scales
authors.forename: M F
authors.initials: MF
authors.lastname: Finley
authors.forename: R H
authors.initials: RH
authors.lastname: Scheller
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D002135:Calcium-Binding Proteins; D002395:Catecholamines / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D004594:Electrophysiology; D008561:Membrane Fusion; D008562:Membrane Glycoproteins / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D016716:PC12 Cells; D010743:Phospholipids / Q000378:metabolism; D020033:Protein Isoforms; D050683:R-SNARE Proteins; D051381:Rats; D050600:SNARE Proteins; D022142:Secretory Vesicles / Q000378:metabolism*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000378:metabolism*; D050857:Synaptotagmins; D033921:Vesicular Transport Proteins
chemical_list: D002135:Calcium-Binding Proteins; D002395:Catecholamines; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D010743:Phospholipids; D020033:Protein Isoforms; D050683:R-SNARE Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins; D050857:Synaptotagmins; D002118:Calcium