title: Chromatographic detection of captopril using 4-dimethylaminobenzaldehyde as spray reagent.
abstract: Thin layer chromatographic method, using a mixture of acetone:ethanol in the ratio of 9:1 as a developing solvent system, was used to detect captopril in its formulation. The developed chromatogram was sprayed with 4-dimethylaminobenzaldehyde. The product formed by reaction of captopril with 4-dimethylaminobenzaldehyde gave a yellow colour. Rf of captopril is 0.56.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
authors.forename: U
authors.initials: U
authors.lastname: Ajali
authors.forename: B K
authors.initials: BK
authors.lastname: Chukwurah
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry*; D002216:Captopril / Q000032:analysis*; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D013607:Tablets
chemical_list: D001547:Benzaldehydes; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D013607:Tablets; D002216:Captopril; C510241:p-dimethylaminobenzaldehyde