Eotaxin and the attraction of eosinophils to the asthmatic lung.
Eosinophilic leukocytes accumulate in high numbers in the lungs of asthmatic patients, and are believed to be important in the pathogenesis of asthma. A potent eosinophil chemoattractant is produced in the asthmatic lung. This small protein, the chemokine eotaxin, is synthesized by a number of different cell types, and is stimulated by interleukin-4 and interleukin-13, which are produced by T-helper (Th)2 lymphocytes. Low molecular weight compounds have been developed that can block the eotaxin receptor C-C chemokine receptor (CCR)3, and prevent stimulation by eotaxin. This provides the potential for orally available drugs that can prevent eosinophil recruitment into the lung and the associated damage and dysfunction.
Conroy
D M
DM
Leukocyte Biology Section, Biomedical Sciences Division, Imperial College School of Medicine, London, UK. d.conroy@ic.ac.uk
Williams
T J
TJ
D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D001853:Bone Marrow / Q000473:pathology / Q000503:physiopathology; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000502:physiology*; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000378:metabolism / Q000502:physiology; D018418:Th2 Cells / Q000502:physiology
C515456:CCL11 protein, human; C515350:CCR3 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D054397:Receptors, CCR3; D019707:Receptors, Chemokine