title: Absorption and excretion of orally administered inositol hexaphosphate (IP(6) or phytate) in humans.
abstract: A study of the pharmacokinetic profile (oral absorption and renal excretion) of inositol hexaphosphate or phytate (IP(6)) is presented. Seven healthy volunteers were following a IP(6) poor diet (IP(6)PD) in a first period, and on IP(6) normal diet (IP(6)ND) in a second one. When following the IP(6)PD they become deficient in IP(6), the basal levels found in plasma (0.07+/- 0.01 mg/L) being clearly lower than those found when IP(6)ND was consumed (0.26+/- 0.03 mg/L). During the restriction period the maximum concentration in plasma were obtained 4 h after the ingestion of a single dose of IP(6), observing almost the same renal excretion profiles for the three different commercial sources and doses. After the IP(6) restriction period, volunteers were on IP(6)ND, reaching normal plasma and urinary IP(6) values in 16 days. Thus, the normal plasma and urinary concentrations, can be obtained either by consumption of a IP(6)ND taking a long time or in a short period by IP(6) supplements.
authors.affiliation: Laboratory of Renal Lithiasis Research, Faculty of Science, University of Illes Balears, 07071 Palma de Mallorca, Spain. dqufg0@ps.uib.es
authors.forename: F
authors.initials: F
authors.lastname: Grases
authors.forename: B M
authors.initials: BM
authors.lastname: Simonet
authors.forename: I
authors.initials: I
authors.lastname: Vucenik
authors.forename: R M
authors.initials: RM
authors.lastname: Prieto
authors.forename: A
authors.initials: A
authors.lastname: Costa-Bauzá
authors.forename: J G
authors.initials: JG
authors.lastname: March
authors.forename: A M
authors.initials: AM
authors.lastname: Shamsuddin
mesh_terms: D000042:Absorption; D000328:Adult; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010833:Phytic Acid / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D010833:Phytic Acid