title: IL-1 genotype and adult periodontitis among young New Zealanders.
abstract: Several recent studies have investigated the association between interleukin-1 genotype and periodontitis in clinical samples, where generalizability is an issue. The aim of this study was to investigate the association between adult periodontitis and IL-1 genotype in a population-based sample of 26-year-olds. Based on probing depth (PD) measurements, participants were divided into three disease groups: "Severe" (1+ teeth with 5+mm PD; N = 25), "Moderate" (2+ teeth with 4+mm PD; N = 36), and "Controls" (the remainder; N = 800). The "periodontitis-associated genotype" (PAG; Kornman et al., 1997) was present in 20.0% of the "Severe" group and in 34.8% of "Controls", whereas the IL-1A(+4845) [1,1]/IL-1B(+3953) [2,2] genotype was present in 12.0% and 0.9%, respectively. After controlling for sex, smoking status, and plaque levels, we found that those with IL-1B(+3953) [1,1]/IL-1A(+4845) [2,2] had 12.3 times the odds of being in the "Severe" group. Analysis of these data suggests that the IL-1A(+4845) [1,1]/IL-1B(+3953) [2,2] genotype is associated with periodontal disease in this young population. Future periodontal data collections as this cohort ages are required to confirm the predictive value of that genotype.
authors.affiliation: Department of Oral Health, School of Dentistry, The University of Otago, Dunedin, New Zealand. mthomson@gandalf.otago.ac.nz
authors.forename: W M
authors.initials: WM
authors.lastname: Thomson
authors.forename: S J
authors.initials: SJ
authors.lastname: Edwards
authors.forename: D P
authors.initials: DP
authors.lastname: Dobson-Le
authors.forename: G R
authors.initials: GR
authors.lastname: Tompkins
authors.forename: R
authors.initials: R
authors.lastname: Poulton
authors.forename: D A
authors.initials: DA
authors.lastname: Knight
authors.forename: A W
authors.initials: AW
authors.lastname: Braithwaite
mesh_terms: D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D015331:Cohort Studies; D003774:Dental Plaque Index; D005260:Female; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D009520:New Zealand; D016017:Odds Ratio; D010514:Periodontal Pocket / Q000145:classification; D010518:Periodontitis / Q000145:classification / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D011159:Population Surveillance; D012680:Sensitivity and Specificity; D012737:Sex Factors; D012907:Smoking / Q000503:physiopathology
chemical_list: D007375:Interleukin-1