title: Two-dimensional finite element model for oxygen transfer in cross-flow hollow fiber membrane artificial lungs.
abstract: A predictive, two-dimensional model with good absolute accuracy for flow and mass transfer in cross-flow hollow fiber membrane artificial lungs is developed. The proposed model is able to predict the gas transfer to water flowing outside and perpendicular to hollow fibers in the artificial lung. The model uses a finite element technique to solve the Navier-Stokes equations and the convection-diffusion equation on the computational domain of a unit fiber cell. Subsequent stream-wise and cross-wise unit fiber cells are then coupled/assembled to the relationship between the oxygen transfer rate and flow rate of a cross-flow hollow fiber membrane artificial lung. The model is compared to experimental water data obtained by perfusing three commercial artificial lungs with water.
authors.affiliation: Institute of Biomedical Technology, Hydraulics Laboratory, Ghent University, Gent, Belgium.
authors.forename: P W
authors.initials: PW
authors.lastname: Dierickx
authors.forename: D S
authors.initials: DS
authors.lastname: de Wachter
authors.forename: P R
authors.initials: PR
authors.lastname: Verdonck
mesh_terms: D001187:Artificial Organs; D055592:Biophysical Phenomena; D001703:Biophysics; D004867:Equipment Design; D020342:Finite Element Analysis; D006801:Humans; D008168:Lung; D008567:Membranes, Artificial; D010100:Oxygen
chemical_list: D008567:Membranes, Artificial; D010100:Oxygen