Portal hypertension secondary to Langerhans cell histiocytosis.
We report two children, aged 2 and 2 1/2 years, with multisystem Langerhans cell histiocytosis (LCH). Both were administered chemotherapy, with apparently good response. However, hepatic fibrosis and portal hypertension were detected 5 and 1 1/2 years after therapy, respectively. The first child died after a bout of hematemesis. Hepatic fibrosis can proceed despite apparently successful chemotherapy in LCH.
Bansal
D
D
Division of Pediatric Hematology-Oncology, Advanced Pediatric Center, Chandigarh.
Marwaha
R K
RK
Trehan
A
A
Poddar
U
U
Radotra
B D
BD
D002675:Child, Preschool; D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis / Q000209:etiology*; D008297:Male