title: First Synthesis of Caerulomycin C.
abstract: The first synthesis of caerulomycin C (1), an antibiotic produced by Streptomyces caeruleus, is reported. This molecule, which exhibits a 2,3,4,6-tetrasubstituted pyridine structure, was prepared from 3,4-dimethoxypyridine in a five-step sequence. The methodology involves metalation, transmetalation, aromatic cross-coupling, and halogen migration reactions.
authors.affiliation: Laboratoire de Chimie Organique Fine et Hétérocyclique de l' Institut de Recherche en Chimie Organique Fine, URA CNRS 1429, Institut National des Sciences Appliquées de Rouen, BP 08, 76131 Mont-Saint-Aignan Cédex, France.
authors.forename: François
authors.initials: F
authors.lastname: Trécourt
authors.forename: Bruno
authors.initials: B
authors.lastname: Gervais
authors.forename: Marc
authors.initials: M
authors.lastname: Mallet
authors.forename: Guy
authors.initials: G
authors.lastname: Quéguiner