title: A comparison of ON-PUMP vs OFF-PUMP coronary artery bypass surgery among low, intermediate, and high-risk patients: the Hartford Hospital experience.
abstract: BACKGROUND
  Off-pump coronary artery bypass (OP-CAB) graft surgery is being used with increasing frequency. This study was designed to compare OP-CAB outcomes with conventional surgical revascularization using cardiopulmonary bypass (CPB) in patients with varying risk categories at a high-volume center.
  
  
  RESULTS
  Between 1/1/1999 and 1/31/2001, bypass surgery was performed on 1,312 patients, including 348 OP-CAB cases and 964 CPB cases. Compared to CPB cases, OP-CAB patients were more likely to be female and had a lower incidence of three vessel coronary artery disease, prior percutaneous intervention, and prior bypass surgery. Postoperatively, OP-CAB patients had a lower incidence of renal failure and prolonged ventilatory support, as well as a lower composite endpoint of inhospital mortality, perioperative myocardial infarction, cerebrovascular accident, and/or renal failure. In addition, OP-CAB patients required fewer transfusions and had a shorter total length of hospital stay. In general, morbidity and mortality increased in both OP-CAB and CPB groups with increasing Parsonnet score.
  
  
  CONCLUSIONS
  OP-CAB surgery is a safe and effective alternative to conventional coronary artery bypass graft (CABG) surgery, with a lower incidence of major in-hospital adverse clinical events and a decreased requirement for medical resources. Adverse OP-CAB outcomes correlate well with pre-operative Parsonnet Score.
authors.affiliation: Divisions of Cardiology and Cardiothoracic Surgery of the Heart Center, Hartford Hospital, Hartford, USA.
authors.forename: R G
authors.initials: RG
authors.lastname: McKay
authors.forename: R A
authors.initials: RA
authors.lastname: Mennett
authors.forename: R C
authors.initials: RC
authors.lastname: Gallagher
authors.forename: L
authors.initials: L
authors.lastname: Horowitz
authors.forename: H
authors.initials: H
authors.lastname: Takata
authors.forename: H B
authors.initials: HB
authors.lastname: Low
authors.forename: J A
authors.initials: JA
authors.lastname: Hammond
authors.forename: D J
authors.initials: DJ
authors.lastname: Underhill
authors.forename: P L
authors.initials: PL
authors.lastname: Preissler
authors.forename: C B
authors.initials: CB
authors.lastname: Humphrey
authors.forename: L H
authors.initials: LH
authors.lastname: Ellison
authors.forename: W E
authors.initials: WE
authors.lastname: Boden
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D016022:Case-Control Studies; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome