NAD and glutathione modulate sensitivity of bone marrow cells to oxidative stress.
We studied in vitro cytostatic effect of doxorubicin on bone marrow cells preincubated with NAD and reduced glutathione. The presence of NAD and glutathione in the medium potentiated membrane toxicity of this antibiotic, but prevented its toxic effects on intracellular pool of pyridine nucleotides during oxidative stress.
Egorova
A B
AB
Department of Pathophysiology, Training Course of Functional Diagnostics, Krasnoyarsk State Medical Academy. onmpi@krsk.infotel.ru
Uspenskaya
Y A
YA
Nefedov
V P
VP
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D004317:Doxorubicin / Q000633:toxicity*; D005978:Glutathione / Q000494:pharmacology*; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D009243:NAD / Q000494:pharmacology*; D009336:Necrosis; D018384:Oxidative Stress
D000903:Antibiotics, Antineoplastic; D009243:NAD; D004317:Doxorubicin; D005978:Glutathione