A new method for surgical treatment of the short bowel syndrome.
This study was aimed to investigate the electrophysiological and morphological characteristics resulting from the structural and functional transformation of gastric tissue transplanted to the small intestine. Twelve adult mongrel dogs were studied up to 3 years. Gastric transplants preserved its main microstructure and minimal compensatory-adaptive processes developed in the mucosa and muscle layers of the graft. A significant influence on the electrical activity of the small intestine was observed, with a 10% reduction of the slow wave frequency (SWF) in the proximal and distal jejunum adjacent to the graft after meals. The SWF of the gastric graft itself, however, corresponded to the frequency of the native stomach, did not depend and was not associated with adjacent intestinal areas. In summary, the stomach graft transplanted to the small intestine keeps the properties of gastric tissue, there are functional adaptations to conditions of digestion in the small intestine and the graft has minimal effects on intestinal motility.
Tamazashvili
T S
TS
Experimental Pathology Department, N.V. Sklifosovsky First Aid Research Centre, B. Sukharevskaya, 3 Moscow, Russia, 129010.
Popova
T S
TS
Titova
G P
GP
Platonova
G A
GA
Tropskaya
N S
NS
de Paz-Arias
R
R
González-Gallego
J
J
Vasiljev
V A
VA
Culebras
J M
JM
D000818:Animals; D013505:Digestive System Surgical Procedures / Q000379:methods; D004285:Dogs; D004594:Electrophysiology; D012778:Short Bowel Syndrome / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*