title: Ileoanal pouch function is related to postprandial pouch tone.
abstract: BACKGROUND
  Functional impairments are frequently observed in patients with an ileoanal pouch. Meal ingestion increases pouch tone and motility. Little is known, however, about the influence of meal-stimulated pouch characteristics on pouch function. The aim was to characterize basal and postprandial pouch motor and sensory characteristics in relation to clinical pouch function in patients with an ileoanal pouch.
  
  
  METHODS
  Nineteen patients with an ileoanal pouch, without faecal incontinence but with either a high stool frequency (n = 8) or an adequate stool frequency (n = 11), underwent pressure distension of the pouch, by which pouch compliance and sensitivity characteristics were assessed using an electronic barostat. A set pressure procedure was performed to assess the influence of a meal on pouch tone and motility.
  
  
  RESULTS
  Mean(s.d.) compliance was 10(6) and 11(4) ml/mmHg in the groups with poor and adequate pouch function respectively (P not significant). Mean(s.d.) visual analogue scale scores (0-10 cm) for urge at the highest pressure of 28 mmHg were 2.3(1.0) versus 2.3(2.4) cm respectively (P not significant); those for pain were 0.8(1.0) versus 0.5(0.7) (P not significant). Postprandially mean(s.d.) pouch volume decreased by 70(24) per cent in the group with poor pouch function and 29(25) per cent in the group with adequate pouch function (P < 0.01). The frequency and amplitude of phasic pouch contractions increased significantly postprandially, but no differences in motility characteristics were observed between the two groups.
  
  
  CONCLUSIONS
  In patients with uniform pouch design and follow-up after pouch construction, pouch compliance and sensitivity were no different between patients with normal and high stool frequency; however, postprandial pouch tone was increased significantly in patients with a high stool frequency.
authors.affiliation: Department of Gastroenterology-Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Steens
authors.forename: W A
authors.initials: WA
authors.lastname: Bemelman
authors.forename: W J
authors.initials: WJ
authors.lastname: Meijerink
authors.forename: G
authors.initials: G
authors.lastname: Griffioen
authors.forename: R A
authors.initials: RA
authors.lastname: van Hogezand
authors.forename: A A
authors.initials: AA
authors.lastname: Masclee
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000503:physiopathology / Q000601:surgery; D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000503:physiopathology / Q000601:surgery; D003187:Compliance; D004435:Eating / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology*; D011312:Pressure; D016737:Proctocolectomy, Restorative; D012299:Rimantadine / Q000031:analogs & derivatives*; D012677:Sensation / Q000502:physiology
chemical_list: C098414:polirem; D012299:Rimantadine