title: First Stereocontrolled Synthesis of the (3S,5R,7R,10R,11R)-C1-C13 Fragment of Nystatin A(1).
abstract: A convergent stereoselective synthesis of the (3S,5R,7R,10R,11R)-C1-C13 fragment of Nystatin A(1) is reported in this paper. This fragment contains an all-syn-1,3,5-triol subunit and a syn-1,2-diol moiety. The main features of the synthesis are the enzymatic desymmetrization of a meso diol to obtain an enantiomerically pure syn-4,6-dihydroxy-2-keto-phosphonate, chiral sulfoxide chemistry to prepare an alpha-(R)-hydroxyaldehyde and 2-trimethylsilyl thiazole reagent to synthesize a syn-alpha,beta-(R,S)-dihydroxy aldehyde.
authors.affiliation: Dipartimento di Chimica, Università degli Studi della Basilicata, Via N. Sauro 85, 85100 Potenza, Italy.
authors.forename: Guy
authors.initials: G
authors.lastname: Solladié
authors.forename: Nicole
authors.initials: N
authors.lastname: Wilb
authors.forename: Claude
authors.initials: C
authors.lastname: Bauder
authors.forename: Carlo
authors.initials: C
authors.lastname: Bonini
authors.forename: Licia
authors.initials: L
authors.lastname: Viggiani
authors.forename: Lucia
authors.initials: L
authors.lastname: Chiummiento