Epstein-Barr virus in patients with immunodeficiency disorders.
The Epstein-Barr virus (EBV), one of eight known human herpesviruses, causes a wide spectrum of diseases under certain conditions. In particular, in the setting of immunodeficiency, which includes primary or secondary/acquired immunodeficiencies, they have been increasingly reported. The major clinical phenotype is the EBV genome-positive lymphoproliferative disorder, which ranges from benign lymphoproliferation to malignant lymphoma with cytogenetic alterations. Severe or fatal infectious mononucleosis may develop in some patients with immunodeficiencies such as X-linked lymphoproliferative disease.
Okano
M
M
Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan. moto-oka@med.hokudai.ac.jp
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000628:therapy / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000628:therapy / Q000821:virology; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology