title: Translocation t(4; 6)(q21; q27) in a case of primary thrombocythaemia in transformation.
abstract: We report a case of primary thrombocythaemia showing a translocation t(4; 6)(q21; q27) five years after diagnosis. The patient had been treated with hydroxyurea. The clinical picture at the time was consistent with transformation. Karyotypic abnormalities are rare in this disease and are reviewed.
authors.affiliation: Servicio de Hematología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain. ikrsnik@hupa.insalud.es
authors.forename: I
authors.initials: I
authors.lastname: Krsnik
authors.forename: T
authors.initials: T
authors.lastname: Ferro
authors.forename: J
authors.initials: J
authors.lastname: García Suárez
authors.forename: Y
authors.initials: Y
authors.lastname: Vázquez Mazariego
authors.forename: P
authors.initials: P
authors.lastname: Cabello
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4; D002896:Chromosomes, Human, Pair 6; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D007621:Karyotyping; D013920:Thrombocythemia, Essential / Q000188:drug therapy / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D006918:Hydroxyurea