Drug-induced nonconvulsive status epilepticus with low dose of tiagabine.
In placebo-controlled trials, the overall incidence of nonconvulsive status epilepticus was no higher in the tiagabine-treated group than in the placebo-group. Case reports of nonconvulsive status epilepticus under tiagabine suggested a specific role of dose levels, since in these patients symptoms occurred mostly at 40 mg/day or higher. We report a case of complex partial status epilepticus in a patient receiving a low dose of tiagabine and review all 11 case reports of nonconvulsive status epilepticus in patients on tiagabine, with regard to daily doses. Our analysis suggests an individual risk threshold of unknown aetiology.
Fitzek
S
S
Department of Neurology, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany. Sabine.Fitzek@med.uni-jena.de
Hegemann
S
S
Sauner
D
D
Bönsch
D
D
Fitzek
C
C
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008297:Male; D009557:Nipecotic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis; D000078308:Tiagabine
D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine