Polymorphisms in promiscuous PXR: an explanation for interindividual differences in drug clearance?
Forman
B M
BM
Division of Molecular Medicine, The Gonda Diabetes & Genetic Research Center, The Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. bmforman@earthlink.net
D006801:Humans; D008657:Metabolic Clearance Rate / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D011987:Receptors, Steroid / Q000235:genetics*; D015262:Xenobiotics / Q000493:pharmacokinetics*
D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D015262:Xenobiotics