Drug targeting to choroidal neovascularization.
Subfoveal choroidal neovascularization (CNV) causes significant visual loss, especially in patients with age-related macular degeneration (AMD). Several pharmaceutical treatments that use anti-angiogenic agents have been tried to inhibit the activity of CNV experimentally and clinically. In general, however, systemically administered drugs may reach not only targeted tissues but also other tissues, resulting in unwanted side effects. Also, to maintain therapeutic levels of the drugs in targeted tissues, frequent administration for an extended period of time is required. To solve these problems, drug delivery systems targeted to the CNV are being developed. Anatomic characteristics of CNV tissues resemble those of tumor vasculature, exhibiting enhanced permeability and retention effect. Drug targeting to CNV may be feasible in the same manner as it is to tumors. In this review, we describe two approaches of drug targeting to CNV: passive targeting and active targeting.
Kimura
H
H
Department of Ophthalmology, Nagoya City University Medical School, Mizuho-ku, Nagoya, 4678601, Aichi, Japan. hkimura@med.nagoya-cu.ac.jp
Yasukawa
T
T
Tabata
Y
Y
Ogura
Y
Y
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015703:Antigens, CD; D020256:Choroidal Neovascularization / Q000188:drug therapy*; D003510:Cyclohexanes; D016503:Drug Delivery Systems; D000071063:Endoglin; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D010539:Permeability; D011142:Polyvinyl Alcohol / Q000008:administration & dosage; D011956:Receptors, Cell Surface; D012717:Sesquiterpenes / Q000008:administration & dosage; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis / Q000276:immunology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D003510:Cyclohexanes; C064206:ENG protein, human; D000071063:Endoglin; D018796:Immunoconjugates; D011956:Receptors, Cell Surface; D012717:Sesquiterpenes; D019010:Vascular Cell Adhesion Molecule-1; D011142:Polyvinyl Alcohol; D000077609:O-(Chloroacetylcarbamoyl)fumagillol