title: [A case of lymphangioleiomyomatosis with carcinomatous lymphangiosis].
abstract: A 66-year-old woman had a history of partial gastrectomy and resection of the residual stomach because of early gastric cancer and its recurrence. She had been suffering from dyspnea on effort, hemosputum, and cough since the age of 52 years. Chronic pulmonary emphysema and bronchial asthma were diagnosed when she was 59. On January 31, 1996, she was admitted to UOEH hospital with a complaint of increased dyspnea. In spite of treatment with oxygen, steroid, and inhaled anti-cholinergic agent, her condition deteriorated. Subsequently, she had DIC, respiratory failure and reticulolinear opacities were seen on chest radiographs, and she died 2 weeks after admission. At autopsy, the lung specimen revealed numerous cystic spaces surrounded by a proliferation of smooth muscle cells. Immunohistological examination showed these cells to be positive for HMB-45. Signet cells were seen in the lymphatics and vessels, and hemosiderin-laden macrophages were found in the alveolar spaces. This was a rare case of lymphangioleiomyomatosis with carcinomatous lymphangiosis.
authors.affiliation: Department of Respiratory Disease, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: C
authors.initials: C
authors.lastname: Yoshii
authors.forename: T
authors.initials: T
authors.lastname: Imanaga
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Kawanami
authors.forename: T
authors.initials: T
authors.lastname: Kawajiri
authors.forename: H
authors.initials: H
authors.lastname: Oomori
authors.forename: M
authors.initials: M
authors.lastname: Kido
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018192:Lymphangioleiomyomatosis / Q000175:diagnosis / Q000473:pathology*; D008207:Lymphatic Metastasis; D058950:Melanoma-Specific Antigens; D009130:Muscle, Smooth / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis; D009360:Neoplastic Cells, Circulating / Q000473:pathology*
chemical_list: D000951:Antigens, Neoplasm; D015415:Biomarkers; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins