A Novel Asymmetric Route to the 1,3-Disubstituted Tetrahydroisoquinoline, (-)-Argemonine.
Chiral bicyclic lactam 13 was converted to the natural product (-)-argemonine 9 in six steps. This novel route to argemonine represents a general strategy for the preparation of chiral 1,3-disubstituted tetrahydroisoquinolines.
Munchhof
Michael J.
MJ
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523.
Meyers
A. I.
AI