title: Synthesis of an orthogonally protected precursor to the glycan repeating unit of the bacterial cell wall.
abstract: [reaction: see text]. A synthesis of stereochemically pure and orthogonally protected N-acetyl-(2-deoxy-2-aminoglucopyranosyl)-beta-[1,4]-N-acetylmuramyl (NAG-NAM) monopeptide (2), the glycopeptide core of lipid II and of the bacterial cell wall repeating unit, is reported.
authors.affiliation: Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Saha
authors.forename: M S
authors.initials: MS
authors.lastname: Van Nieuwenhze
authors.forename: W J
authors.initials: WJ
authors.lastname: Hornback
authors.forename: J A
authors.initials: JA
authors.lastname: Aikins
authors.forename: L C
authors.initials: LC
authors.lastname: Blaszczak
mesh_terms: D001419:Bacteria / Q000737:chemistry*; D002473:Cell Wall / Q000737:chemistry; D004187:Disaccharides / Q000138:chemical synthesis*; D004224:Diterpenes / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D010457:Peptidoglycan / Q000737:chemistry*
chemical_list: C442272:11-epi-helioporin B; D004187:Disaccharides; D004224:Diterpenes; D007202:Indicators and Reagents; D010457:Peptidoglycan