title: Asymmetric Synthesis of Calyculin C. 1. Synthesis of the C(1)-C(25) Fragment.
abstract: We report our synthesis of the C(1)-C(25) fragment of serine/threonine phosphatase PP1 and PP2A inhibitor, calyculin C. Synthetic efforts were directed initially toward the synthesis of a spiroketal core fragment (7), which culminated in completion of the bottom half of the natural product. The synthesis of fragment 7 and subsequent elaboration relied on an allylboration strategy for introduction of chirality. The C(1)-C(8) fragment representing the potentially unstable tetraene moiety was introduced as a separate entity.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095.
authors.forename: Gerard R.
authors.initials: GR
authors.lastname: Scarlato
authors.forename: John A.
authors.initials: JA
authors.lastname: DeMattei
authors.forename: Lee S.
authors.initials: LS
authors.lastname: Chong
authors.forename: Anthony K.
authors.initials: AK
authors.lastname: Ogawa
authors.forename: Mavis R.
authors.initials: MR
authors.lastname: Lin
authors.forename: Robert W.
authors.initials: RW
authors.lastname: Armstrong