Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair.
Many genes that are required for fertility have been identified in model organisms (). Mutations in these genes cause infertility due to defects in development of the germ cell lineage, but the organism is otherwise healthy. Although human reproduction is undoubtedly as complex as that of other organisms, very few fertility loci have been mapped (). This is in spite of the prevalence of human infertility, the lack of effective treatments to remedy germ cell defects, and the cost to couples and society of assisted reproductive techniques. Fifteen percent of couples are infertile and half of all cases can be traced to the male partner. Aside from defects in sperm production, most infertile men are otherwise healthy. This review is divided into two distinct parts to discuss work that: (i) led to the identification of several genes on the Y chromosome that likely function in sperm production; and (ii) implicates DNA repair in male infertility via increased frequency of mutations in DNA from men with meiotic arrest.
Fox
M S
MS
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143-0546, USA. vulpes7@itsa.ucsf.edu
Reijo Pera
R A
RA
D000818:Animals; D004260:DNA Repair / Q000235:genetics / Q000502:physiology; D000075364:Deleted in Azoospermia 1 Protein; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009154:Mutation / Q000235:genetics; D009845:Oligospermia / Q000235:genetics; D016601:RNA-Binding Proteins / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics
C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D016601:RNA-Binding Proteins