title: Analysis of respiratory mechanics by impulse oscillometry in non-sedated and diazepam-sedated swine.
abstract: Analysis of respiratory mechanics using impulse oscillometry is applicable to sedated, or non-sedated (trained) pigs when they are fixed in a sling. In this study, the influence of the following sources of variability on measurement results was examined: (i) sedation with diazepam; (ii) body weight of animals (ranging in age: 40 to 102 days); and (iii) time of the measurement (circadian influences). The following parameters were examined: respiratory rate (RR), tidal volume (v(t)), spectral resistance, reactance and coherence, each at 5, 10, 15 and 20 Hz (R5,...R20, X5,...X20, CO5...CO20, respectively), distal respiratory resistance (Rdist), and proximal airway resistance (Rprox). After sedation (using 1.5 mg diazepam per kg body weight), RR and v(t) decreased significantly. There was a significant improvement of CO5, CO10 and CO15. Increase in body weight was strongly correlated to v(t), furthermore to spectral resistance parameters. Impulse oscillometry system (IOS) parameters showed only slight non-significant alterations in dependency on the time of day. In consequence, different sources of variability must be taken into account when performing IOS measurements in swine.
authors.affiliation: Research Centre of Medical Technology and Biotechnology, Bad Langensalza, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Klein
authors.forename: P
authors.initials: P
authors.lastname: Reinhold
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight; D002940:Circadian Rhythm; D003975:Diazepam / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D009991:Oscillometry / Q000662:veterinary; D012044:Regression Analysis; D015656:Respiratory Mechanics / Q000187:drug effects* / Q000502:physiology; D013552:Swine / Q000502:physiology*
chemical_list: D006993:Hypnotics and Sedatives; D003975:Diazepam