[Angiogenesis and macrophage infiltration in Borrmann type IV gastric cancer].
The clinical significance of angiogenesis was investigated in Borrmann type IV gastric cancer. Tumors with high microvessel density (MVD) often metastasized to the liver and lymph nodes. A significant correlation was recognized between macrophage infiltration and MVD. However, MVD was not a prognostic factor. Peritoneal dissemination was a prognostic factor in Borrmann type IV gastric cancer. Thus, angiogenesis plays an important role in the metastasis, but not prognosis in Borrmann type IV gastric cancer.
Koga
J
J
Department of Surgery and Science (Surgery II), Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582.
Kakeji
Y
Y
Sumiyoshi
Y
Y
Kimura
Y
Y
Shibahara
K
K
Emi
Y
Y
Maehara
Y
Y
Sugimachi
K
K
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D016228:Endothelial Growth Factors / Q000032:analysis; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000032:analysis; D008264:Macrophages / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D011379:Prognosis; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D016228:Endothelial Growth Factors; D008222:Lymphokines; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C067980:CD68 antigen, human; D000097382:CD68 Molecule