title: [Inclusion body myositis associated with sacroidosis: a report of 3 cases].
abstract: Inclusion body myositis (IBM) is a severe form of idiopathic inflammatory myopathy. A predominantly T CD8+ lymphocytic infiltrate, with focally non-necrotizing muscular fiber invasion, and rimmed-vacuoles are specific histological signs. A few cases of IBM associated with other dysimmune diseases have been reported, but only once with systemic sarcoidosis. We report three cases of muscular sarcoidosis associated with IBM. This very uncommon observation suggests that major complex of histocompatibility, soluble factors, cytokines and adhesion molecules could be involved. Our cases are a novel example of associated dysimmune diseases.
authors.affiliation: Service d'Anatomie Pathologique, Hôpital Pellegrin, CHU Bordeaux, place Amélie Raba-Léon, 33076 Bordeaux Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Bouillot
authors.forename: M
authors.initials: M
authors.lastname: Coquet
authors.forename: X
authors.initials: X
authors.lastname: Ferrer
authors.forename: A
authors.initials: A
authors.lastname: Lagueny
authors.forename: J P
authors.initials: JP
authors.lastname: Leroy
authors.forename: C
authors.initials: C
authors.lastname: Vital
mesh_terms: D001706:Biopsy; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D009135:Muscular Diseases / Q000150:complications* / Q000473:pathology; D018979:Myositis, Inclusion Body / Q000150:complications / Q000473:pathology*; D012507:Sarcoidosis / Q000150:complications* / Q000473:pathology; D014617:Vacuoles / Q000473:pathology