title: Unusual Terpenes with Novel Carbon Skeletons from the West Indian Sea Whip Pseudopterogorgia elisabethae (Octocorallia)(1).
abstract: From the hexane solubles of the West Indian gorgonian Pseudopterogorgia elisabethae collected near San Andrés Island, Colombia, were isolated a marine diterpenoid, two nor-diterpenoids, and a bisnor-diterpenoid, all of which possess most unusual carbocyclic skeletons. The structures and relative configurations of novel metabolites elisabethins A-C (1-3) and elisabanolide (4) were elucidated by interpretation of overall spectral data, which included 2D NMR correlation methods; IR, UV, and accurate mass measurements (HREIMS); chemical reactions; and X-ray diffraction analyses. One of these, elisabethin B (2), showed significant differential antitumor activity, and compounds 3 and 4 have weak in vitro antituberculosis activity.
authors.affiliation: Department of Chemistry, University of Puerto Rico, P.O. Box 23346, Río Piedras, Puerto Rico 00931-3346.
authors.forename: Abimael D.
authors.initials: AD
authors.lastname: Rodríguez
authors.forename: Eduvigis
authors.initials: E
authors.lastname: González
authors.forename: Songping D.
authors.initials: SD
authors.lastname: Huang