title: ATM, a central controller of cellular responses to DNA damage.
abstract: Mutations in the ATM gene lead to the genetic disorder ataxia-telangiectasia. ATM encodes a protein kinase that is mainly distributed in the nucleus of proliferating cells. Recent studies reveal that ATM regulates multiple cell cycle checkpoints by phosphorylating different targets at different stages of the cell cycle. ATM also functions in the regulation of DNA repair and apoptosis, suggesting that it is a central regulator of responses to DNA double-strand breaks.
authors.affiliation: The Queensland Institute of Medical Research, and Department of Pathology and Surgery, University of Queensland, PO Royal Brisbane Hospital, Brisbane, Qld4029, Australia.
authors.forename: K K
authors.initials: KK
authors.lastname: Khanna
authors.forename: M F
authors.initials: MF
authors.lastname: Lavin
authors.forename: S P
authors.initials: SP
authors.lastname: Jackson
authors.forename: T D
authors.initials: TD
authors.lastname: Mulhern
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001260:Ataxia Telangiectasia / Q000473:pathology / Q000532:radiotherapy; D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000378:metabolism; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D004268:DNA-Binding Proteins; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D017434:Protein Structure, Tertiary; D011836:Radiation Tolerance; D016615:Telomere / Q000502:physiology; D025521:Tumor Suppressor Proteins
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases