Biologically active proteins from natural product extracts.
The term "biologically active proteins" is almost redundant. All proteins produced by living creatures are, by their very nature, biologically active to some extent in their homologous species. In this review, a subset of these proteins will be discussed that are biologically active in heterologous systems. The isolation and characterization of novel proteins from natural product extracts including those derived from microorganisms, plants, insects, terrestrial vertebrates, and marine organisms will be reviewed and grouped into several distinct classes based on their biological activity and their structure.
O'Keefe
B R
BR
Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702-1201, USA. okeefe@dtpax2.ncifcrf.gov
D000595:Amino Acid Sequence; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry; D001419:Bacteria / Q000737:chemistry; D001426:Bacterial Proteins; D001685:Biological Factors / Q000737:chemistry*; D002352:Carrier Proteins / Q000737:chemistry; D007313:Insecta / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010944:Plants / Q000737:chemistry; D011161:Porifera / Q000737:chemistry*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment; D014714:Vertebrates
D019380:Anti-HIV Agents; D001426:Bacterial Proteins; D001685:Biological Factors; D002352:Carrier Proteins; D011506:Proteins; C107733:cyanovirin N