The coming impact of gene expression profiling on the diagnosis and treatment of HCV-associated liver disease.
Gene expression profiling allows the level of activity of thousands of genes to be monitored simultaneously. Profiling is often carried out on specialized chips or slides, which have microarrays of gene targets at predetermined addresses. In the immediate future, microarrays promise to yield new insights into hepatitis C virus (HCV) pathogenesis and to produce 'signatures' that can be used in molecular diagnostics. In the longer-term, they may aid the development of serological tests by identifying genes encoding secretory proteins produced by HCV-infected livers, and they may suggest new avenues for disease intervention by detecting genes whose products are retained in the infected liver.
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Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. ab8@doc.mssm.edu
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D020869:Gene Expression Profiling; D006526:Hepatitis C / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy / Q000821:virology; D006801:Humans; D008099:Liver / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis