title: Lobular breast cancer: how useful is breast magnetic resonance imaging?
abstract: OBJECTIVE
  To review magnetic resonance imaging (MRI) findings in lobular breast carcinoma, the in situ or infiltrating subtype, with special attention to the dynamic curves with the aim to evaluate possible differences with ductal carcinoma.
  
  
  METHODS
  In 2 years, 27 patients with lobular and one with tubular carcinoma underwent MRI at the Istituto Nazionale Tumori of Milan.
  
  
  RESULTS
  All lobular carcinomas demonstrated early or late enhancement (100% sensitivity), without significant differences in morphology compared with ductal carcinoma, but frequently with a different shape of the dynamic curves.
  
  
  CONCLUSIONS
  Due to its infiltrative growth associated to only limited connective tissue reaction, lobular carcinoma often encounters difficulties in mammographic diagnosis. In contrast, MRI can be very helpful in evaluating the true extension of the disease, especially when breast conservation is considered. Due to a more consistent fibrotic stroma, these lesions sometimes show a delayed enhancement, which suggests that more than one set of subtracted images should be evaluated during MRI analysis.
authors.affiliation: Unit of Diagnostic Radiology A, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy. trecate@istitutotumori.mi.it
authors.forename: G
authors.initials: G
authors.lastname: Trecate
authors.forename: J D
authors.initials: JD
authors.lastname: Tess
authors.forename: D
authors.initials: D
authors.lastname: Vergnaghi
authors.forename: S
authors.initials: S
authors.lastname: Bergonzi
authors.forename: G
authors.initials: G
authors.lastname: Mariani
authors.forename: C
authors.initials: C
authors.lastname: Ferraris
authors.forename: R
authors.initials: R
authors.lastname: Musumeci
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity