title: Efficacy of sildenafil citrate for the treatment of erectile dysfunction in men taking serotonin reuptake inhibitors.
abstract: OBJECTIVE
  This study was an evaluation of whether sildenafil citrate is effective for the treatment of erectile dysfunction in men taking concomitant serotonin-reuptake-inhibiting antidepressants.
  
  
  METHODS
  A retrospective subanalysis of combined data from 10 phase II/III double-blind, placebo-controlled, fixed- and flexible-dose trials (12-26 weeks) identified a group of men with erectile dysfunction receiving 5 to 200 mg/day of sildenafil (N=65) or placebo (N=33) and concomitant serotonin-reuptake-inhibiting antidepressants. Efficacy was measured by responses to questions from the International Index of Erectile Function on ability to achieve erection, ability to maintain erection, ejaculation frequency, orgasm frequency, and sexual desire.
  
  
  RESULTS
  Patients with erectile dysfunction receiving sildenafil and concomitant serotonergic antidepressants had significantly greater improvements in ability to achieve and maintain an erection, frequency of ejaculation, and orgasm frequency than did patients receiving placebo, without increased sexual desire.
  
  
  CONCLUSIONS
  Sildenafil significantly improved erectile dysfunction in patients taking concomitant serotonergic antidepressants.
authors.affiliation: Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, USA. geon@unm.edu
authors.forename: H G
authors.initials: HG
authors.lastname: Nurnberg
authors.forename: A
authors.initials: A
authors.lastname: Gelenberg
authors.forename: T B
authors.initials: TB
authors.lastname: Hargreave
authors.forename: W M
authors.initials: WM
authors.lastname: Harrison
authors.forename: R L
authors.initials: RL
authors.lastname: Siegel
authors.forename: M D
authors.initials: MD
authors.lastname: Smith
mesh_terms: D003865:Major Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D007172:Erectile Dysfunction / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D012720:Severity of Illness Index; D000068677:Sildenafil Citrate; D013450:Sulfones; D016896:Treatment Outcome
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D017367:Selective Serotonin Reuptake Inhibitors; D000068677:Sildenafil Citrate; D013450:Sulfones