Herpesvirus DNA in peripheral blood mononuclear cells of some patients with Meniere's disease.
Herpes simplex virus-1 (HSV) or varicella zoster virus (VZV) DNA was detected by nested polymerase chain reaction in peripheral blood mononuclear cells of patients with Meniere's disease (one of 28 patients for HSV-1, 2 of 28 patients for VZV) during acute illness (within 5 days after onset). On the other hand, neither HSV-1 DNA or VZV DNA was detected in PBMCs of 50 age- and sex-matched healthy individuals and 50 pregnant women. These findings may imply that reactivation of HSV- 1 or VZV may be associated with the development of some cases of Meniere's disease.
Takahash
K
K
Department of Microbiology, Fukushima Medical University, Fukushima, Japan. k-tak@fmu.ac.jp
Aono
T
T
Shichinohe
M
M
Tamura
M
M
Iwata
Y
Y
Yamanishi
K
K
Shigeta
S
S
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000302:isolation & purification*; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology*; D008297:Male; D008575:Meniere Disease / Q000097:blood / Q000276:immunology / Q000821:virology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D000914:Antibodies, Viral; D004279:DNA, Viral