title: Evaluation of fluoride release from commercially available fluoride varnishes.
abstract: BACKGROUND
  The authors conducted a study to evaluate the fluoride released from two fluoride varnishes: Duraphat (Colgate-Palmolive Co., New York) and Duraflor (Pharmascience Inc., Montreal). Fluoride-release information for these commercially available dental products has not been available to clinicians treating children at risk of developing dental caries.
  
  
  METHODS
  The authors painted enamel slabs from primary molar teeth with 30 milligrams of two varnishes: nine samples received Duraphat, nine received Duraflor and five samples served as controls. The samples were immersed in buffered calcium phosphate solution (pH, 6.0) to simulate the oral environment, and the amount of fluoride released was measured weekly for six months.
  
  
  RESULTS
  From week 4 to the end of the study, Duraphat released significantly more fluoride than Duraflor. Duraflor continued releasing fluoride until week 19, while Duraphat released fluoride until week 28. The authors found greater variability in the release of fluoride from the Duraflor samples than from the Duraphat samples. Two-thirds of the fluoride was released from both products by the end of the study.
  
  
  CONCLUSIONS
  Both varnishes released fluoride for five to six months. However, the two products exhibited differences in their release kinetics.
  
  
  CONCLUSIONS
  These findings show that either of the fluoride varnishes may maintain a high level of fluoride in plaque fluid around primary teeth over a long period, but that the availability of fluoride may vary among tubes of the same product and between the two products themselves.
authors.affiliation: Department of Orthodontics, University of Washington, Seattle, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Castillo
authors.forename: P
authors.initials: P
authors.lastname: Milgrom
authors.forename: E
authors.initials: E
authors.lastname: Kharasch
authors.forename: K
authors.initials: K
authors.lastname: Izutsu
authors.forename: M
authors.initials: M
authors.lastname: Fey
mesh_terms: D001682:Biological Availability; D005459:Fluorides / Q000032:analysis*; D005460:Fluorides, Topical / Q000737:chemistry*; D006801:Humans; D012969:Sodium Fluoride / Q000737:chemistry*
chemical_list: C120870:Duraflor; D005460:Fluorides, Topical; C023807:sodium fluoride topical preparation; D012969:Sodium Fluoride; D005459:Fluorides