Chromatographic detection of captopril using 4-dimethylaminobenzaldehyde as spray reagent.
Thin layer chromatographic method, using a mixture of acetone:ethanol in the ratio of 9:1 as a developing solvent system, was used to detect captopril in its formulation. The developed chromatogram was sprayed with 4-dimethylaminobenzaldehyde. The product formed by reaction of captopril with 4-dimethylaminobenzaldehyde gave a yellow colour. Rf of captopril is 0.56.
Ajali
U
U
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Chukwurah
B K
BK
D001547:Benzaldehydes / Q000737:chemistry*; D002216:Captopril / Q000032:analysis*; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D013607:Tablets
D001547:Benzaldehydes; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D013607:Tablets; D002216:Captopril; C510241:p-dimethylaminobenzaldehyde