Microcirculation is similar in ischemic and venous ulcers.
Microcirculation of 15 ischemic and 15 venous ulcers, their scars, and intact surrounding skin were examined in order to demonstrate their similarities in the development and healing process. Subpapillary and nutritive perfusion of four areas were investigated by a laser Doppler perfusion imager (arbitrary units) and capillary microscopy (capillaries/mm2): one ulcer area without granulation tissue (no wound healing) and one with granulation tissue (ulcer healing); one skin area adjacent to the ulcer (1-8 mm) (scar developed from ulcer areas) and one distant (12-25 mm; intact skin). Areas without granulation tissue in ischemic and venous ulcers were similar, demonstrating a lack of capillaries (0.13 +/- 0.52; 0.93 +/- 2.09) and low laser Doppler flux (0.81 +/- 0.69; 1.47 +/- 1.17; P > 0.05 for each). In granulation tissue of both ulcers there was a tendency to a higher capillary density (0.67 +/- 1.40; 5.60 +/- 2.32; P < 0.0001 for venous ulcers) and a higher laser Doppler flux (1.15 +/- 0.67; 4.04 +/- 1.62; P < 0.0001 for venous ulcers) than in areas without granulation tissue. In scars of ischemic and venous ulcers capillary density (8.18 +/- 8.84; 13.60 +/- 5.45) and laser Doppler flux (1.72 +/- 1.00; 1.94 +/- 1.45) were similar (P > 0.05). In skin distant from ischemic ulcers very high capillary density (24.63 +/- 1.89) was associated with low laser Doppler flux (0.99 +/- 0.59); distant from venous ulcer capillary density was moderate (10.47 +/- 3.42) while laser Doppler flux was high (3.77 +/- 1.62; P < 0.0001 between both groups). The development and healing process of ischemic and venous ulcers is similar. Nutritive and subpapillary perfusion are involved in ulcer healing. In intact skin surrounding ischemic and venous ulcers, microcirculation is different due to the underlying pathophysiology.
Gschwandtner
M E
ME
Department of Medical Angiology, Vienna General Hospital, University of Vienna Medical School, Währinger Gürlel 18-20, A-1090, Austria
Ambrózy
E
E
Marić
S
S
Willfort
A
A
Schneider
B
B
Böhler
K
K
Gaggl
U
U
Ehringer
H
H
D000368:Aged; D000369:Aged, 80 and over; D002196:Capillaries / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension; D007511:Ischemia / Q000150:complications / Q000503:physiopathology*; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation; D007871:Leg Ulcer / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000000981:diagnostic imaging / Q000473:pathology; D008853:Microscopy / Q000379:methods; D008875:Middle Aged; D012867:Skin / Q000098:blood supply* / Q000473:pathology; D018608:Ultrasonography, Doppler; D014647:Varicose Ulcer / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D014689:Venous Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology