Leukocyte trafficking in alveoli and airway passages.
Many pulmonary diseases preferentially affect the large airways or the alveoli. Although the mechanisms are often particular to each disease process, site-specific differences in leukocyte trafficking and the regulation of inflammation also occur. Differences in the process of margination, sequestration, adhesion, and migration occur that can be attributed to differences in anatomy, hemodynamics, and the expression of proteins. The large airways are nourished by the bronchial circulation, whereas the pulmonary circulation feeds the distal lung parenchyma. The presence of different cell types in large airways from those in alveoli might contribute to site-specific differences in the molecular regulation of the inflammatory process.
Doerschuk
C M
CM
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA. cmd22@po.cwru.edu
D000818:Animals; D001980:Bronchi / Q000098:blood supply; D002465:Cell Movement; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007962:Leukocytes / Q000502:physiology*; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D011650:Pulmonary Alveoli / Q000502:physiology* / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000502:physiology