title: Inhibition of drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis by diospyrin, isolated from Euclea natalensis.
abstract: The binaphthoquinoid, diospyrin, was isolated from Euclea natalensis A.DC., and evaluated for its activity against drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis. The minimal inhibitory concentration (MIC) of diospyrin was found to be 100 microg/ml for all the M. tuberculosis strains.
authors.affiliation: Department of Botany, University of Pretoria, Pretoria 0002, South Africa.
authors.forename: N
authors.initials: N
authors.lastname: Lall
authors.forename: J J
authors.initials: JJ
authors.lastname: Meyer
mesh_terms: D018432:Drug Resistance, Multiple; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D009285:Naphthoquinones; D010936:Plant Extracts; C043546:diospyrin