Red blood cells Li+-Na+ exchange kinetics. Normal adolescents with hypertensive ancestors.
Li/Na exchange kinetic parameters (Km, Vmax) were determined in red blood cells from normal adolescents with or without hypertensive antecessors, as well as plasmatic levels of high density lipoproteins. In red blood cells from adolescents with hypertensive antecessors, we observed significantly lower Km values compared to the other group. HDL-c (high density lipoprotein-cholesterol) plasmatic values did not differ significantly. Furthermore, in normal adolescents without hypertensive ancestors, the Vmax significantly correlated with the HDL-c plasmatic values. The results indicated that the Km parameter of this transport mechanism is affected by genetic factors and data are also presented to demonstrate that the Vmax parameter is affected by environmental (cellular) factors. It is suggested that Li/Na exchange Km values would be a risk index of essential hypertension development.
Corchs
J L
JL
Department of Physiology, School of Medicine, National University of Rosario, Santa Fe, Argentina. gmujica@citynet.net.ar
Taborda
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Serrani
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D000293:Adolescent; D002414:Cations, Monovalent; D008076:Cholesterol, HDL / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D017136:Ion Transport; D007700:Kinetics; D016014:Linear Models; D008094:Lithium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D002414:Cations, Monovalent; D008076:Cholesterol, HDL; D008094:Lithium; D012964:Sodium