Synthetic studies toward gambierol. Convergent synthesis of the octacyclic polyether core.
[structure: see text]. A convergent synthetic route to the octacyclic polyether core of gambierol, a marine polycyclic ether toxin, has been developed. The synthesis involves construction of two fragments representing the ABC and EFGH ring systems followed by their coupling via a B-alkyl Suzuki reaction.
Fuwa
H
H
Department of Chemistry, Graduate School of Science, The University of Tokyo, and CREST, Japan Science and Technology Corporation, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Sasaki
M
M
Tachibana
K
K
D000818:Animals; D002922:Ciguatoxins; D004988:Ethers, Cyclic / Q000138:chemical synthesis*; D056890:Eukaryota / Q000737:chemistry*; D007202:Indicators and Reagents; D008387:Marine Toxins / Q000138:chemical synthesis*; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D035964:Oxocins
D002922:Ciguatoxins; D004988:Ethers, Cyclic; D007202:Indicators and Reagents; D008387:Marine Toxins; D011083:Polycyclic Compounds; C435770:gambierol; D035964:Oxocins