title: The association between Viadent use and oral leukoplakia.
abstract: Recently, leukoplakia of the maxillary vestibule was described in patients with no traditional risk factors but who had used Viadent products. We designed a case-control study to evaluate the hypothesis that Viadent users were more likely to have lesions. One hundred and forty-eight cases and controls were identified through the Section of Oral and Maxillofacial Pathology. Cases and controls were administered a questionnaire about Viadent use and other known risks. Results of crude, stratified, and logistic regression analyses showed that use of Viadent products was a risk indicator for leukoplakia (adjusted OR = 9.7, 95% CI = 4.7-21.6), with a strong dose-response relation.
authors.affiliation: Section of Health Service Research, College of Dentistry, The Ohio State University, Columbus 43218-2357, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Mascarenhas
authors.forename: C M
authors.initials: CM
authors.lastname: Allen
authors.forename: J
authors.initials: J
authors.lastname: Loudon
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D000470:Alkaloids / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D053119:Benzophenanthridines; D016022:Case-Control Studies; D017266:Dental Prosthesis; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007546:Isoquinolines; D007971:Leukoplakia / Q000139:chemically induced* / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D016017:Odds Ratio; D009820:Ohio / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D053119:Benzophenanthridines; D007546:Isoquinolines; C005705:sanguinarine