title: A model to evaluate bone substitutes for immediate implant placement.
abstract: A calcified alloplast was evaluated as a gap-filling material around implants placed immediately into fresh extraction sockets. Periodontal measurements and computed tomography scans were obtained to evaluate the clinical effectiveness of the alloplast when compared with demineralized freeze-dried bone. To determine whether this alloplast would be a suitable grafting material, 14 patients were selected to evaluate the extraction socket as a model for routine histologic confirmation of the efficacy and biocompatibility of bone substitutes. The results of this study showed the following: (1) human extraction sockets can be models for the study of bone/implant interaction; (2) the alloplast was well tolerated and demonstrated no inflammation through histologic evaluation of core biopsies; (3) the alloplast was a suitable material when used as a gap-filling graft in sockets around immediately placed implants; and (4) dental computed tomography scans and periodontal measurements around grafted implants 6 months after the procedure provide valuable clinical information about graft healing and osteointegration.
authors.affiliation: Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, NY, USA. robert.glickman@nyu.edu
authors.forename: R S
authors.initials: RS
authors.lastname: Glickman
authors.forename: R
authors.initials: R
authors.lastname: Bae
authors.forename: V
authors.initials: V
authors.lastname: Karlis
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology / Q000517:prevention & control*; D018786:Bone Substitutes; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D006801:Humans; D008954:Models, Biological; D016348:Osseointegration; D011108:Polymers; D014081:Tooth Extraction / Q000009:adverse effects; D020390:Tooth Socket / Q000502:physiology*
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; C407025:HTR bioplant; D011108:Polymers