Correlation between the levels of circulating adhesion molecules and PR3-ANCA in Wegener's granulomatosis.
OBJECTIVE
The adhesion of neutrophils to the vascular endothelial cells appears to be important for the pathogenesis of vasculitis in Wegener's granulomatosis (WG). To determine the pathological significance of the neutrophil adhesion, we have examined and evaluated the relationships between the levels of adhesion molecules and proteinase-3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA), and between the levels of TNF-alpha and disease activities in WG.


METHODS
sELAM-1 and sICAM-1 in sera from WG and healthy donors were detected by ELISA. SLex and LFA-1 on neutrophils were detected by flow cytometry.


RESULTS
The level of sICAM-1 was significantly higher in active WG than in inactive WG, tending to reflect individual disease activities. There was no difference in the level of sELAM-1 between WG patients and healthy donors.


CONCLUSIONS
Our study suggests that the adhesion of neutrophils to the vascular endothelium is significant for the pathogenesis of the vasculitis in WG.
Takizawa
M
M
Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo, Japan. takitaki@sweet.ocn.ne.jp
Maguchi
S
S
Nakamaru
Y
Y
Miyatake
Y
Y
Fukuda
S
S
Inuyama
Y
Y
D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053146:Myeloblastin; D012697:Serine Endopeptidases / Q000097:blood*
D019268:Antibodies, Antineutrophil Cytoplasmic; D015815:Cell Adhesion Molecules; D012697:Serine Endopeptidases; D053146:Myeloblastin