The use of interferon for emergency prophylaxis of marburg hemorrhagic fever in monkeys.
The possibility of emergency prophylaxis of Marburg hemorrhagic fever with leukocytic and recombinant interferons was studied in experiments on Cercopithecus aethiops. None of the agents protected monkeys from the action of lethal doses of Marburg virus. Recombinant interferon-alpha(2)administered according to the emergency prophylaxis schedule prolonged the mean life-span of monkeys injected with Marburg virus in doses of 100 and 1000 LD50 by 1.9 and 6.1 days, respectively.
Kolokol'tsov
A A
AA
Vector Research Center of Virology and Biotechnology, Ministry of Health of the Russian Federation, Kol'tsovo, Novosibirsk Region. vector@vector.nsk.su
Davidovich
I A
IA
Strel'tsova
M A
MA
Nesterov
A E
AE
Agafonova
O A
OA
Agafonov
A P
AP
D000208:Acute Disease; D000818:Animals; D001769:Blood / Q000821:virology; D001831:Body Temperature; D002522:Chlorocebus aethiops; D006168:Guinea Pigs; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000276:immunology / Q000627:therapeutic use*; D008379:Marburg Virus Disease / Q000276:immunology / Q000517:prevention & control*; D029024:Marburgvirus / Q000502:physiology; D011994:Recombinant Proteins; D013534:Survival; D014766:Viremia
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins