Direct Formation of Secondary and Tertiary Alkylzinc Bromides and Subsequent Cu(I)-Mediated Couplings.
Secondary and tertiary alkylzinc bromides can be generated from the direct oxidative addition of Rieke zinc to secondary and tertiary alkyl bromides in high yield. These organozinc reagents have been found to undergo copper-catalyzed conjugate addition, cross-coupling with acid chlorides, and carbocupration to activated alkynes.
Rieke
Reuben D.
RD
Rieke Metals, Inc., 6133 Heide Lane, Lincoln, Nebraska 68512.
Hanson
Mark V.
MV
Brown
Jeffrey D.
JD
Niu
Q. Jason
QJ