[Gq/G11-mediated cellular signal pathway and its significance for cardiac diseases].
Transmembrane and intracellular signalling pathways are at the center of many cellular regulatory processes. One of the most ubiquitous transmembrane signalling mechanisms involves heterotrimeric guaninnucleotide binding proteins (G-proteins). Members of the Gq/11-family of G-proteins couple receptors to beta-isoforms of phospholipase C. During recent years the establishment of various transgenic animal models has provided new insights into the physiological and pathological role of this signalling pathway. This overview summarizes recent data on the role of Gq/11-mediated signalling processes in platelet activation and myocardial hypertrophy. The increasing knowledge on the molecular mechanisms underlying these processes may lead to new preventive and therapeutic options for the management of coronary artery disease or heart failure.
Offermanns
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Pharmakologisches Institut Universität Heidelberg Im Neuenheimer Feld 366 69120 Heidelberg, Germany. Stefan-Offermanns@urz.uni-heidelberg.de
D000818:Animals; D030801:Animals, Genetically Modified; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics / Q000503:physiopathology*; D043802:GTP-Binding Protein alpha Subunits, Gq-G11; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D015539:Platelet Activation / Q000235:genetics / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; C087996:STK19 protein, human; D043802:GTP-Binding Protein alpha Subunits, Gq-G11; D020962:Heterotrimeric GTP-Binding Proteins