title: Modulation of host cell signalling by enteropathogenic and Shiga toxin-producing Escherichia coli.
abstract: The majority of Escherichia coli strains are harmless symbionts in the intestinal tract. However, there are several pathogenic forms, which are responsible for various diseases in humans and live stock. In this review we discuss the interactions between Shiga toxin-producing E. coli and enteropathogenic E. coli and their target host cells, describing their strategies to activate specific cellular signalling pathways which lead to subversion of critical physiological functions. We mainly concentrate on those pathogenic mechanisms that are dependent on a functional type III secretion system, but we also briefly discuss additional factors that contribute to the specific pathogenic profiles of Shiga toxin-producing E. coli and enreropathogenic E. coli.
authors.affiliation: German Research Centre for Biotechnology (GBF), Braunschweig.
authors.forename: A U
authors.initials: AU
authors.lastname: Kresse
authors.forename: C A
authors.initials: CA
authors.lastname: Guzmán
authors.forename: F
authors.initials: F
authors.lastname: Ebel
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism / Q000494:pharmacology; D004926:Escherichia coli / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D007422:Intestines / Q000166:cytology / Q000382:microbiology*; D022603:Shiga Toxins / Q000096:biosynthesis*; D015398:Signal Transduction; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D022603:Shiga Toxins