Andinermals A-C, antiplasmodial constituents from Andira inermis.
Bioassay-guided fractionation of the leaves from Andira inermis was undertaken as part of a screening program to verify the traditional use of herbal remedies against malaria. Among the isolated phenolic compounds three novel 2-arylbenzofuran-3-carbaldehydes, andinermal A-C, were obtained together with a new flavanonol glycoside, taxifolin-3-O-(3"-O-trans-cinnamoyl)-alpha-L-rhamnopyranoside.
Kraft
C
C
Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Königin-Luise-Str. 2-4, D-14195, Berlin, Germany.
Jenett-Siems
K
K
Siems
K
K
Solis
P N
PN
Gupta
M P
MP
Bienzle
U
U
Eich
E
E
D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay / Q000379:methods; D007887:Fabaceae / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
D000447:Aldehydes; D000962:Antimalarials; D001572:Benzofurans; D007529:Isoflavones; C448099:andinermal; C121707:7,3'-dihydroxy-4'-methoxyisoflavone