title: Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties.
abstract: GC-MS analysis on the essential oil (CC-oil) of Cinnamomum cassia stem bark led to the identification of cinnamaldehyde (CNA, 1), 2-hydroxycinnamaldehyde (2-CNA), coumarin (2), and cinnamyl acetate. The major volatile flavor in CC-oil was found to be 2-CNA. Coumarin was first isolated from this plant by phytochemical isolation and spectroscopic analysis. CNA and CC-oil showed potent cytotoxicity, which was effectively prevented by N-acetyl-L-cysteine (NAC) treatment. Intraperitoneal administration with CNA considerably decreased malondialdehyde (MDA) formation and glutathione S-transferase activity in rats. These results suggest that CC-oil and CNA can regulate the triggering of hepatic drug-metabolizing enzymes by the formation of a glutathione-conjugate.
authors.affiliation: College of Pharmacy, Kyungsung University, Pusan 608-736, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Choi
authors.forename: K T
authors.initials: KT
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Ka
authors.forename: W T
authors.initials: WT
authors.lastname: Jung
authors.forename: H J
authors.initials: HJ
authors.lastname: Jung
authors.forename: H J
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000449:Aldehyde Reductase / Q000378:metabolism; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D027424:Cinnamomum / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008315:Malondialdehyde / Q000737:chemistry; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D019441:Plant Epidermis / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013778:Tetrazolium Salts; D013844:Thiazoles; D014407:Tumor Cells, Cultured; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile; D013778:Tetrazolium Salts; D013844:Thiazoles; D008315:Malondialdehyde; D000449:Aldehyde Reductase; D000815:Aniline Hydroxylase; D014969:Xanthine Oxidase; D000633:Aminopyrine N-Demethylase; D005982:Glutathione Transferase; C022616:thiazolyl blue