title: Development of chronic colitis is dependent on the cytokine MIF.
abstract: The cytokine macrophage-migration inhibitory factor (MIF) is secreted by a number of cell types upon induction by lipopolysaccharide (LPS). Because colitis is dependent on interplay between the mucosal immune system and intestinal bacteria, we investigated the role of MIF in experimental colitis. MIF-deficient mice failed to develop disease, but reconstitution of MIF-deficient mice with wild-type innate immune cells restored colitis. In addition, established colitis could be treated with anti-MIF immunoglobulins. Thus, murine colitis is dependent on continuous MIF production by the innate immune system. Because we found increased plasma MIF concentrations in patients with Crohn's disease, these data suggested that MIF is a new target for intervention in Crohn's disease.
authors.affiliation: Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
authors.forename: Y P
authors.initials: YP
authors.lastname: de Jong
authors.forename: A C
authors.initials: AC
authors.lastname: Abadia-Molina
authors.forename: A R
authors.initials: AR
authors.lastname: Satoskar
authors.forename: K
authors.initials: K
authors.lastname: Clarke
authors.forename: S T
authors.initials: ST
authors.lastname: Rietdijk
authors.forename: W A
authors.initials: WA
authors.lastname: Faubion
authors.forename: E
authors.initials: E
authors.lastname: Mizoguchi
authors.forename: C N
authors.initials: CN
authors.lastname: Metz
authors.forename: M
authors.initials: M
authors.lastname: Alsahli
authors.forename: T
authors.initials: T
authors.lastname: ten Hove
authors.forename: A C
authors.initials: AC
authors.lastname: Keates
authors.forename: J B
authors.initials: JB
authors.lastname: Lubetsky
authors.forename: R J
authors.initials: RJ
authors.lastname: Farrell
authors.forename: P
authors.initials: P
authors.lastname: Michetti
authors.forename: S J
authors.initials: SJ
authors.lastname: van Deventer
authors.forename: E
authors.initials: E
authors.lastname: Lolis
authors.forename: J R
authors.initials: JR
authors.lastname: David
authors.forename: A K
authors.initials: AK
authors.lastname: Bhan
authors.forename: C
authors.initials: C
authors.lastname: Terhorst
authors.forename: M A
authors.initials: MA
authors.lastname: Sahli
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood* / Q000276:immunology; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D003092:Colitis / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy; D003424:Crohn Disease / Q000097:blood* / Q000276:immunology; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D008070:Lipopolysaccharides / Q000633:toxicity; D008262:Macrophage Activation / Q000187:drug effects; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D009687:Nuclear Proteins; D011828:Radiation Chimera; D015431:Weight Loss
chemical_list: D004268:DNA-Binding Proteins; D008070:Lipopolysaccharides; D008263:Macrophage Migration-Inhibitory Factors; D009687:Nuclear Proteins; C499311:RAG2 protein, human; C499308:Rag2 protein, mouse; C064655:V(D)J recombination activating protein 2