Synthesis and Properties of C-Azalyxonucleosides.
1-beta-(4-Imidazoyl)- and 1-beta-(5-uracilyl)-1,4-dideoxy-1,4-imino-L-lyxitols were synthesized stereoselectively via a sequential procedure by the addition of the corresponding metal salts of heterocycles, Swern oxidation, reductive aminocyclization, and deprotection. Their structures were determined based on X-ray crystallography. From the NMR measurements of their N-acyl derivatives, two rotational isomers were observed. Their bioassay is also described.
Momotake
Atsuya
A
Department of Chemistry, Faculty of Science, Graduate School of Science and Technology, and Chemical Analysis Center, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba city 263-8522, Japan.
Mito
Jun
J
Yamaguchi
Kentaro
K
Togo
Hideo
H
Yokoyama
Masataka
M