Modulation of substance P and somatostatin receptors in cutaneous lymphocytic inflammatory and tumoral infiltrates.
BACKGROUND
The expression of receptors for neuropeptides in the skin is modified in skin diseases.


OBJECTIVE
We studied the cutaneous expression of substance P (SP) and somatostatin (SOM) receptors (SPR and SSTR, respectively) in skin affected by cutaneous inflammatory or tumoral T-cell infiltrates because these two neuropeptides are the ones most involved in inflammation.


METHODS
We revealed expression of these receptors using a binding in situ technique that gave highly specific results. Skin biopsies were incubated with biotinylated neuropeptides (SP or SOM).


RESULTS
In normal skin, SSTR were observed on blood vessels, smooth muscle fibres and sweat glands. SSTR expression was modified only when expressed by keratinocytes in Ofuji papuloerythroderma and by plasmocytes in plasmocytoma. SPR distribution was not modified in subjects with atopic dermatitis or lupus. The expression of SPR in the epidermis was diminished in Ofuji papuloerythroderma and parapsoriasis and absent in mycosis fungoides.


CONCLUSIONS
These results suggest that malignant lymphocytic infiltrates can inhibit SPR expression on keratinocytes.
Misery
L
L
INSERM U346 and Department of Dermatology, Edouard Herriot Hospital, Lyon, France. laurent.misery@univ-st-etienne.fr
Bourchanny
D
D
Kanitakis
J
J
Schmitt
D
D
Claudy
A
A
D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D007801:Langerhans Cells / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000378:metabolism; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D017481:Receptors, Somatostatin / Q000378:metabolism*; D012867:Skin / Q000276:immunology / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology
D018040:Receptors, Neurokinin-1; D017481:Receptors, Somatostatin