Myosin heavy chain expression and plasticity: role of myoblast diversity.
Muscle fibers exhibit a limited capacity to alter their myosin heavy chain expression in response to various stimuli. Recent results pertinent to this observation are discussed, and a hypothetical scheme is presented whereby the contribution of myonuclei from distinct populations of myogenic precursors may account for this limited adaptive range.
Parry
D J
DJ
Department of Cellular and Molecular Medicine, Faculty of Medicine and Centre for Neuromuscular Disease, University of Ottawa, Ontario, Canada. dparry@uottawa.ca
D000818:Animals; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005333:Fetus / Q000502:physiology; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000166:cytology* / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D018995:Myosin Heavy Chains / Q000378:metabolism*; D027161:Satellite Cells, Perineuronal / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
D014157:Transcription Factors; D018995:Myosin Heavy Chains