title: Assessment of intrathoracic blood volume as an indicator of cardiac preload: single transpulmonary thermodilution technique versus assessment of pressure preload parameters derived from a pulmonary artery catheter.
abstract: OBJECTIVE
  To analyze the clinical value of a new device (PiCCO) for cardiac output measurement and volume preload parameter assessment, based on transpulmonary thermodilution technique, as an alternative to the pulmonary artery thermodilution technique and assessment of pressure preload parameters derived from the pulmonary artery catheter.
  
  
  METHODS
  Prospective, controlled, clinical study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Eighteen patients with ejection fraction >50% undergoing coronary artery bypass graft surgery.
  
  
  METHODS
  A baseline measurement was performed after induction of anesthesia under clinical steady-state conditions (T1). Hypovolemia, defined as central venous pressure (CVP) <10 mmHg and pulmonary capillary wedge pressure (PCWP) <12 mmHg, was treated by infusion of 6% hydroxyethyl starch 200/0.5 (7 mL/kg). After 10 minutes, a second measurement (T2) was performed.
  
  
  RESULTS
  The mean difference (bias) between transpulmonary thermodilution cardiac output and pulmonary artery thermodilution cardiac output did not differ at the 2 sample points. Changes in pressure preload parameters of the pulmonary artery catheter (CVP, PCWP) did not correlate with changes in cardiac output or stroke volume, whereas changes in volume preload parameter intrathoracic blood volume (ITBV) of the PiCCO correlated significantly with changes in cardiac output and stroke volume (r = 0.55, p < 0.05; r = 0.62, p < 0.01).
  
  
  CONCLUSIONS
  These results suggest that increased cardiac preload is more reliably reflected by ITBV than by CVP or PCWP. The assessment of ITBV by the transpulmonary single indicator dilution technique is an interesting alternative to the pressure preload parameters.
authors.affiliation: Department of Anaesthesia, University Hospital, Regensburg, Germany. wiesenack@rhananw1/ngate/uni-regensburg.de
authors.forename: C
authors.initials: C
authors.lastname: Wiesenack
authors.forename: C
authors.initials: C
authors.lastname: Prasser
authors.forename: C
authors.initials: C
authors.lastname: Keyl
authors.forename: G
authors.initials: G
authors.lastname: Rödīg
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D002302:Cardiac Output; D002407:Catheterization, Swan-Ganz; D002496:Central Venous Pressure; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure; D012044:Regression Analysis; D013815:Thermodilution