title: Palladium-Catalyzed Carbonylation and Coupling Reactions of Aryl Chlorides and Amines.
abstract: The palladium-catalyzed amidation of electron-deficient aryl chlorides proceeds readily in the presence of low CO pressures and a slight excess of an iodide salt. The rates of amidation are accelerated over those without added salt, and iodide is preferred over bromide or chloride. More electron-rich aryl chlorides were not effectively amidated, either with or without added iodide. We postulate that an intermediate anionic palladium(0) iodide complex is responsible for the enhanced reactivity.
authors.affiliation: Imaging Research and Advanced Development, Eastman Kodak Company, Rochester, New York 14650-1705.
authors.forename: Robert J.
authors.initials: RJ
authors.lastname: Perry
authors.forename: B. David
authors.initials: BD
authors.lastname: Wilson