Novel pyridine-catalyzed reaction of dimethyl acetylenedicarboxylate with aldehydes: formal [2 + 2] cycloaddition leading to 2-oxo-3-benzylidinesuccinates.
[reaction: see text]. The 1,4-zwitterionic intermediate generated from pyridine and DMAD adds to aldehydes in a formal [2 + 2] manner, resulting in the facile synthesis of 2-oxo-3-benzylidinesuccinates.
Nair
V
V
Organic Chemistry Division, Regional Research Laboratory, CSIR, Trivandrum 695 019, India. gvn@csrrltrd.ren.nic.in
Sreekanth
A R
AR
Vinod
A U
AU