Treating the discomfort of oral ulceration resulting from cancer chemotherapy.
Chemotherapy-induced oral mucositis can result in inadequate oral intake, local and systemic infection, a prolonged hospital stay, and increased cost of treatment. Treatment of the pain resulting from this condition can greatly lessen these problems. Hydroxypropyl cellulose gel with benzocaine (Zilactin B) has been shown to effectively reduce the pain of mucositis for up to 3 hours.
Redding
S W
SW
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Haveman
C W
CW
D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001566:Benzocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005782:Gels; D018237:Germinoma / Q000188:drug therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D019226:Oral Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D013280:Stomatitis / Q000139:chemically induced / Q000188:drug therapy*
D000779:Anesthetics, Local; D000970:Antineoplastic Agents; D004338:Drug Combinations; D005782:Gels; D002482:Cellulose; C008079:hydroxypropylcellulose; D001566:Benzocaine