title: Transrectal ultrasound in the diagnosis of prostate cancer: state of the art and perspectives.
abstract: OBJECTIVE
  Transrectal ultrasound (TRUS) is an important tool in diagnosing prostate cancer. However, specificity and sensitivity of conventional grey-scale TRUS for the detection of prostate cancer are disappointingly low. New ultrasound modalities are designed to overcome the disappointing results and improve the use of ultrasound in the diagnosis of prostate cancer. This work is a review of the recent literature, combined with own experiences.
  
  
  METHODS
  The papers were collected using a Medline search, combined with some papers by author selection. The terms used for the Medline search included among other things: transrectal ultrasound, prostate, prostate cancer, prostate biopsies, colour Doppler ultrasound, power Doppler ultrasound, contrast ultrasound. The authors used their own experiences for illustrations of various techniques.
  
  
  CONCLUSIONS
  Although several modalities show a significant improvement in sensitivity and specificity for the detection of prostate cancer, none of the TRUS modalities discussed can replace prostate biopsies as a definitive diagnostic. Several techniques, especially contrast ultrasound, show definitive promise. However, two valid conclusions can be made from the data presented. First: with today's technology, none of the TRUS modalities discussed can replace systemic biopsies in the early detection of prostate cancer. Second: none of the discussed TRUS modalities has found a definitive place in routine clinical practice.
authors.affiliation: Department of University Medical Center, St. Radboud, Nijmegen, The Netherlands. M.Sedelaar@uro.azn.nl
authors.forename: J P
authors.initials: JP
authors.lastname: Sedelaar
authors.forename: P L
authors.initials: PL
authors.lastname: Vijverberg
authors.forename: T M
authors.initials: TM
authors.lastname: De Reijke
authors.forename: J J
authors.initials: JJ
authors.lastname: de la Rosette
authors.forename: P J
authors.initials: PJ
authors.lastname: Kil
authors.forename: J G
authors.initials: JG
authors.lastname: Braeckman
authors.forename: A J
authors.initials: AJ
authors.lastname: Hendrikx
mesh_terms: D005544:Forecasting; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D012007:Rectum; D014463:Ultrasonography / Q000379:methods / Q000639:trends; D018608:Ultrasonography, Doppler