title: Seroprevalence to polio in personnel at a virology institute.
abstract: OBJECTIVE
  To determine the level of immunity to polio in adult personnel at the National Institute for Virology (NIV), South Africa.
  
  
  METHODS
  Polio neutralizing antibodies results on 776 NIV staff members tested between 1979 and 1999 and seroresponses in seronegative personnel given a booster vaccination were analysed.
  
  
  RESULTS
  613 of the 776 (79%) personnel had neutralizing polio antibodies to all three types, independent of age, gender, race or job category. Types 1 and 2 antibodies were found in 92% and 94%, respectively, but type 3 was less prevalent at 87%. Of the 93 persons seronegative to one or more types, 13 failed to respond to the first booster vaccination and 8 remained as non-responders after two booster vaccinations. Of the 19 personnel who were bled four days after booster vaccination, 16 (84%) had already developed an antibody response.
  
  
  CONCLUSIONS
  Most (79%) adult laboratory personnel retained detectable levels of neutralizing antibodies to polio, independent of age, gender, race or job category, and even in those persons lacking detectable antibodies, most (84%) responded with a secondary immune response. Nevertheless the immunity gap, particularly to type 3, mandates routine screening of personnel potentially exposed to wild-type polio virus and a booster vaccination for seronegatives.
authors.affiliation: National Institute for Virology and University of the Witwatersrand, Private Bag X4, Sandringham 2131, South Africa. schoub@niv.ac.za
authors.forename: B D
authors.initials: BD
authors.lastname: Schoub
authors.forename: N K
authors.initials: NK
authors.lastname: Blackburn
authors.forename: J M
authors.initials: JM
authors.lastname: McAnerney
mesh_terms: D000328:Adult; D000488:Allied Health Personnel; D000914:Antibodies, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011051:Poliomyelitis / Q000453:epidemiology*; D017955:Poliovirus / Q000302:isolation & purification*; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D013019:South Africa / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral