[Role of statins in prevention of stroke and dementia].
There is accumulating evidence that statins reduce stroke risk, even though total cholesterol is not a risk factor for stroke. The explanation for this discrepancy is subject to discussion. It should be realised that the beneficial effects of statins on stroke risk have only been demonstrated in a select population, i.e. middle-aged men with ischaemic heart disease. Several clinical trials are underway to examine the effects of statins on stroke risk in more characteristic groups of patients who are at increased risk of developing stroke. The results of these studies should be awaited before statins are recommended for the prevention of stroke. Recently it has been reported that statins lower the risk of developing dementia. These conclusions were drawn from two cross-sectional studies. Because of the nature of the studies, only an association between the use of statins and a lower risk of developing dementia was shown, and not a causal relationship. Experimentally-controlled studies have to be designed to investigate the effect of statins on dementia.
ten Dam
V H
VH
Sectie Gerontologie en Geriatrie, afd. Algemene Interne Geneeskunde, Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden.
Bollen
E L
EL
Westendorp
R G
RG
Meinders
A E
AE
Blauw
G J
GJ
D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003430:Cross-Sectional Studies; D003704:Dementia / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D012306:Risk; D020521:Stroke / Q000378:metabolism / Q000517:prevention & control*
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors