One-pot synthesis of cinnamylamines with various protecting groups from cinnamyl ethers.
The reaction of various alkyl cinnamyl ethers with CSI afforded the corresponding cinnamylamines with various protecting groups, such as -NHMoc, -NHiPoc, -NHCbz, -NHPnz, -NHTroc and -NHAloc. In the case of cinnamyl t-butyl ether and cinnamyl p-methoxybenzyl ether, the corresponding cinnamyl carbamates were formed via a different reaction pathway from the above.
Jung
Y H
YH
Sungkyunkwan University, Organic & Medicinal Chemistry Laboratory, College of Pharmacy, Suwon 440-746, Kyonggi-Do, Korea. yhjung@skku.ac.kr
Kim
J D
JD
D002219:Carbamates / Q000138:chemical synthesis; D004987:Ethers / Q000138:chemical synthesis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011437:Propylamines / Q000138:chemical synthesis*
D002219:Carbamates; D004987:Ethers; D007202:Indicators and Reagents; D011437:Propylamines