title: Kinamycin Biosynthesis. Synthesis, Isolation, and Incorporation of Stealthin C, an Aminobenzo[b]fluorene.
abstract: A new intermediate in the biosynthesis of the benzo[b]fluorene antibiotic, kinamycin D, has been identified. 11-Amino-4,5,9-trihydroxy-2-methyl-10H-benzo[b]fluoren-10-one was synthesized and shown to be present in extracts of Streptomyces murayamaensisfermentations. A deuterated sample was prepared and shown to be specifically incorporated into kinamycin D. This new intermediate, now named stealthin C, is also the probable hydroxylation substrate for the biosynthesis of stealthin A by S. viridochromogenes.
authors.affiliation: Department of Chemistry, Oregon State University, Corvallis, Oregon 97331.
authors.forename: Steven J.
authors.initials: SJ
authors.lastname: Gould
authors.forename: Chris R.
authors.initials: CR
authors.lastname: Melville
authors.forename: Martha C.
authors.initials: MC
authors.lastname: Cone
authors.forename: Jiong
authors.initials: J
authors.lastname: Chen
authors.forename: John R.
authors.initials: JR
authors.lastname: Carney