Interferon regulatory factor 7: a key cellular mediator of LMP-1 in EBV latency and transformation.
Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.
Zhang
L
L
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295, USA. luzhang@med.unc.edu
Pagano
J S
JS
D002472:Cell Transformation, Viral / Q000276:immunology / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D050839:Interferon Regulatory Factor-7; D008954:Models, Biological; D009857:Oncogenes / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000235:genetics; D011499:Protein Processing, Post-Translational; D014763:Viral Matrix Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017735:Virus Latency / Q000502:physiology*
D004268:DNA-Binding Proteins; C037662:EBV-associated membrane antigen, Epstein-Barr virus; C494234:IRF7 protein, human; D050839:Interferon Regulatory Factor-7; D014763:Viral Matrix Proteins