title: Anchoring and bola cationic amphiphiles for nucleotide delivery. Effects of orientation and extension of hydrophobic regions.
abstract: Novel cationic amphiphiles, based on lithocholic acid derivatives with two structural motifs, anchoring lipids and bola lipids, were designed and synthesized. Both bear extended hydrophobic space-filling substituents. A significant effect of the orientation and extension of hydrophobic regions around the ether linkage at the 3-position was found on the efficiency of DNA delivery.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshimura
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
authors.forename: N
authors.initials: N
authors.lastname: Hirashima
authors.forename: M
authors.initials: M
authors.lastname: Nakanishi
authors.forename: T
authors.initials: T
authors.lastname: Ohwada
mesh_terms: D016475:3T3 Cells / Q000378:metabolism; D000818:Animals; D002412:Cations / Q000737:chemistry*; D002784:Cholesterol / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes; D008095:Lithocholic Acid / Q000138:chemical synthesis / Q000378:metabolism*; D008156:Luciferases / Q000378:metabolism; D051379:Mice; D010957:Plasmids; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000378:metabolism*; D014162:Transfection
chemical_list: D002412:Cations; D008055:Lipids; D008081:Liposomes; D013501:Surface-Active Agents; D008095:Lithocholic Acid; D002784:Cholesterol; D008156:Luciferases