title: Synthesis of Anisolylated Aspartyl and Glutamyl Tripeptides.
abstract: A process has been developed for transforming the beta-carboxyl of aspartate and the gamma-carboxyl of glutamate into anisolyl ketones. These ketones are occasional byproducts in peptide synthesis, resulting from deprotection or resin-removal processes in the presence of anisole as a scavenger. The ketone amino acids have been incorporated in a tripeptide by coupling with CBMIT. During peptide bond formation the keto group of the glutamyl residue required protection, which was provided as the ethylene dithioketal.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Berrée
authors.forename: Kieyoung
authors.initials: K
authors.lastname: Chang
authors.forename: Agustín
authors.initials: A
authors.lastname: Cobas
authors.forename: Henry
authors.initials: H
authors.lastname: Rapoport