A novel chromosomal translocation t(3;5)(q12;p15.3) and loss of heterozygosity on chromosome 22 in a multifocal follicular variant of papillary thyroid carcinoma presenting with skin metastases.
Classic genetic rearrangements in papillary carcinoma of the thyroid involve the RET- or TRK proto-oncogenes. We report a novel chromosomal translocation t(3;5)(q12;p15.3), confirmed by fluorescence in situ hybridization, in a multifocal follicular variant of a papillary carcinoma of the thyroid in a 79-year-old woman, with skin metastases as a presenting symptom. Three years earlier, another cutaneous metastasis on her scalp was misdiagnosed as hidradenoma. Four tumour foci were recognized in the thyroid, two with a follicular variant of papillary carcinoma. To detect loss of heterozygosity, 14 chromosomes were investigated with 59 microsatellite markers. A clonal relationship was detected between the two foci of tumour in the thyroid gland containing follicular variant of papillary carcinoma and one of the skin lesions tested, all demonstrating loss of heterozygosity (LOH) in the same region of chromosome 22. Based on earlier reports, the low rate of LOH detected is in agreement with the diagnosis papillary carcinoma of the thyroid. Whole body scintigraphy performed after ablative therapy with radioiodine revealed multiple metastases in the lungs and skeleton. After repeated radioiodine therapy, thyroglobulin under thyroxine suppression became undetectable and post-therapeutic scintigraphy revealed important regression of metastases.
Smit
J W
JW
Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands. j.w.a.smit.endo@lumc.nl
Van Zelderen-Bhola
S
S
Merx
R
R
De Leeuw
W
W
Wessels
H
H
Vink
R
R
Morreau
H
H
D000368:Aged; D001859:Bone Neoplasms / Q000235:genetics / Q000532:radiotherapy / Q000556:secondary; D018265:Carcinoma, Papillary, Follicular / Q000235:genetics* / Q000532:radiotherapy / Q000556:secondary; D002892:Chromosomes, Human, Pair 22; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007621:Karyotyping; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000235:genetics / Q000532:radiotherapy / Q000556:secondary; D012878:Skin Neoplasms / Q000235:genetics / Q000532:radiotherapy / Q000556:secondary*; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000532:radiotherapy / Q000556:secondary; D014178:Translocation, Genetic
D007457:Iodine Radioisotopes