title: Clinical characteristics of autoimmune hepatitis with histological features of acute hepatitis.
abstract: The number of patients with autoimmune hepatitis with histological features of acute hepatitis (AIH-AH) has been increasing recently. Here, the clinical features of patients with AIH-AH have been compared with those of patients with AIH with histological findings of chronic hepatitis (AIH-CH) and liver cirrhosis (AIH-LC). The levels of total serum bilirubin (P<0.05) and serum transaminases (P<0.05) were significantly higher in patients with AIH-AH than in patients with AIH-CH and AIH-LC. However, the serum levels of gamma-globulin (P<0.05) and immunoglobulin G (P<0.05) were significantly lower in AIH-AH than in patients with AIH-CH and AIH-LC. The aggregate score according to the criteria of the International Autoimmune Hepatitis Group in 1999 was also significantly lower in AIH-AH patients than in patients with AIH-CH and AIH-LC (P<0.05). Eleven patients with AIH-AH were treated with corticosteroids, however, the clinical response was insignificant in three patients. In summary, it is difficult to diagnose of patients with AIH-AH using the criteria of the International AIH scoring system. We wish that this scoring system would be modified in the near future.
authors.affiliation: Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-Cho, 791-0295, Ehime, Japan
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Masumoto
authors.forename: Teru
authors.initials: T
authors.lastname: Kumagi
authors.forename: Sk Md Fazle
authors.initials: SM
authors.lastname: Akbar
authors.forename: Tsuneyuki
authors.initials: T
authors.lastname: Ninomiya
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Matsui
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
authors.forename: Norio
authors.initials: N
authors.lastname: Horiike
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji