Re-occurrence of HIV-1 drug mutations after treatment re-initiation following interruption in patients with multiple treatment failure.
Antiretroviral treatment interruption in 20 extensively pre-treated HIV-1 patients with treatment failure led to genotype viral reversion of at least one class of drug-mutation resistance in half of the patients. The only predictive factor of reversion was found to be the duration of interruption. The outgrowth of residual wild-type virus seems not to be a true genetic reversion because drug mutations are detected rapidly at salvage therapy re-initiation.
Delaugerre
C
C
Department of Virology, Pitié-Salpêtrière Hospital, Paris, France.
Valantin
M A
MA
Mouroux
M
M
Bonmarchand
M
M
Carcelain
G
G
Duvivier
C
C
Tubiana
R
R
Simon
A
A
Bricaire
F
F
Agut
H
H
Autran
B
B
Katlama
C
C
Calvez
V
V
D023241:Antiretroviral Therapy, Highly Active; D004334:Drug Administration Schedule; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D009154:Mutation; D012367:RNA, Viral / Q000097:blood; D017211:Treatment Failure
D012367:RNA, Viral