The Kapakahines, Cyclic Peptides from the Marine Sponge Cribrochalina olemda.
Four cyclic peptides, kapakahines A-D, were isolated from the marine sponge Cribrochalina olemda. Their structures including complete stereochemistry were elucidated by spectral analysis and chemical degradation. The unique structural feature of these peptides is the lack of an amide linkage between two tryptophan residues. Instead the ring is closed by a bond from the indole nitrogen of Trp-1 to the beta-carbon of Trp-2.
Yeung
Bryan K. S.
BK
Harbor Branch Oceanographic Institution, Inc.,(2) 5600 North U.S. 1, Fort Pierce, Florida 34936.
Nakao
Yoichi
Y
Kinnel
Robin B.
RB
Carney
John R.
JR
Yoshida
Wesley Y.
WY
Scheuer
Paul J.
PJ
Kelly-Borges
Michelle
M