Transforming growth factor-alpha in the regulation of enterocytic proliferation: part of a puzzle.
The regulation of gut mucosal wound healing after mucosal injury is crucial in re-establishing the epithelial barrier function of the epithelium. However, the exact molecular mechanisms of gut epithelial restitution are still largely unknown. The proliferation and migration of epithelial cells, which contribute to the epithelial wound healing, are complex regulated and, until now, a variety of peptide and nonpeptide factors that take part in this regulation have been identified. Transforming growth factor (TGF)-alpha is one of the well-known proliferation and migration inducing factors in gut epithelial cells, and seems to play an important role in mucosal wound healing. However, less is known about the regulation of TGF-alpha expression itself. Here we discuss the recent advances concerning the role of TGF-alpha in the context of mucosal regeneration.
Steinkamp
M
M
Department of Internal Medicine I, University of Ulm, Germany.
Reinshagen
M
M
D000818:Animals; D002455:Cell Division / Q000502:physiology; D004847:Epithelial Cells / Q000502:physiology*; D007413:Intestinal Mucosa / Q000166:cytology*; D016211:Transforming Growth Factor alpha / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
D016211:Transforming Growth Factor alpha