title: An automated technique for measuring hippocampal volumes from MR imaging studies.
abstract: We describe an automated volumetric measure of the hippocampus obtained with software called the Knowledge-Guided MRI Analysis Program (KGMAP). Postmortem MR images from 56 participants in the Nun Study were used to validate the measure. KGMAP-determined volumes strongly correlated with those obtained with manual tracings and neurofibrillary pathologic findings of Alzheimer disease in the hippocampus. KGMAP provides a rapid and accurate estimate of hippocampal volume that is suitable for use in clinical practice.
authors.affiliation: Institute on Aging, University of South Florida, Tampa 33612-3899, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Gosche
authors.forename: J A
authors.initials: JA
authors.lastname: Mortimer
authors.forename: C D
authors.initials: CD
authors.lastname: Smith
authors.forename: W R
authors.initials: WR
authors.lastname: Markesbery
authors.forename: D A
authors.initials: DA
authors.lastname: Snowdon
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D012984:Software