[Modulation by tauroursodeoxycholic acid of proliferation of the rat ischemic liver hepatocytes].
The influence of the tauroursodeoxycholic acid (TUDCA) on hepatocyte proliferation after 180-minute ischemia of rat liver was investigated. TUDCA in a dose of 200 mg/kg did not change hepatocyte proliferation in the liver of intact rats and had no cytotoxic effect. The preliminary introduction of TUDCA accelerated regenerative processes in the liver in the postischemic period possibly due to synchronization of hepatocyte division. The membrane stabilizing effect of TUDCA manifested in reduction of the liver enzyme activity in blood serum was found.
Danchenko
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Vitebsk Medical University, 210602 Vitebsk, Frunze ave., 27. scidep@vitmed.belpak.vitebsk.by
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects*; D007511:Ischemia / Q000188:drug therapy*; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects; D051381:Rats; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology*
D002756:Cholagogues and Choleretics; D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine