title: Treatment of proctalgia fugax with botulinum A toxin.
abstract: Two recent studies described a temporal association between a high-amplitude and high-frequency myoelectrical activity of the anal sphincter and the occurrence of proctalgia, which suggest that paroxysmal hyperkinesis of the anus may cause proctalgia fugax. We describe a single case of proctalgia fugax responding to anal sphincter injection of Clostridium botulinum type A toxin. The presumed aetiology of proctalgia fugax is discussed and the possible mechanism of action of botulinum toxin (BTX) in this condition is outlined. Botulinum A toxin seems to be a promising treatment for patients with proctalgia fugax, and further trials appear to be worthwhile for this condition, which has been described as incurable.
authors.affiliation: Department of Endoscopy and Motility Unit, Central Hospital, Thessaloniki, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Katsinelos
authors.forename: M
authors.initials: M
authors.lastname: Kalomenopoulou
authors.forename: K
authors.initials: K
authors.lastname: Christodoulou
authors.forename: D
authors.initials: D
authors.lastname: Katsiba
authors.forename: P
authors.initials: P
authors.lastname: Tsolkas
authors.forename: I
authors.initials: I
authors.lastname: Pilpilidis
authors.forename: A
authors.initials: A
authors.lastname: Papagiannis
authors.forename: I
authors.initials: I
authors.lastname: Kapitsinis
authors.forename: I
authors.initials: I
authors.lastname: Vasiliadis
authors.forename: T
authors.initials: T
authors.lastname: Souparis
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007267:Injections; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D012002:Rectal Diseases / Q000188:drug therapy*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A