Association between myeloperoxidase levels and risk of coronary artery disease.
BACKGROUND
Myeloperoxidase (MPO), a leukocyte enzyme that promotes oxidation of lipoproteins in atheroma, has been proposed as a possible mediator of atherosclerosis.


OBJECTIVE
To determine the association between MPO levels and prevalence of coronary artery disease (CAD).


METHODS
Case-control study conducted from July to September 2000 in a US tertiary care referral center, including 158 patients with established CAD (cases) and 175 patients without angiographically significant CAD (controls).


METHODS
Association of MPO levels per milligram of neutrophil protein (leukocyte-MPO) and MPO levels per milliliter of blood (blood-MPO) with CAD risk.


RESULTS
Leukocyte- and blood-MPO levels were both significantly greater in patients with CAD than in controls (P<.001). In multivariable models adjusting for traditional cardiovascular risk factors, Framingham risk score, and white blood cell counts, MPO levels were significantly associated with presence of CAD, with an OR of 11.9 (95% CI, 5.5-25.5) for the highest vs lowest quartiles of leukocyte-MPO and an OR of 20.4 (95% CI, 8.9-47.2) for the highest vs lowest quartiles of blood-MPO.


CONCLUSIONS
Elevated levels of leukocyte- and blood-MPO are associated with the presence of CAD. These findings support a potential role for MPO as an inflammatory marker in CAD and may have implications for atherosclerosis diagnosis and risk assessment.
Zhang
R
R
Department of Cell Biology, Cleveland Clinic Foundation, 9500 Euclid Ave, NC-10, Cleveland, OH 44195, USA.
Brennan
M L
ML
Fu
X
X
Aviles
R J
RJ
Pearce
G L
GL
Penn
M S
MS
Topol
E J
EJ
Sprecher
D L
DL
Hazen
S L
SL
D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology / Q000453:epidemiology; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007962:Leukocytes / Q000201:enzymology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood* / Q000378:metabolism; D015995:Prevalence; D012307:Risk Factors; D018709:Statistics, Nonparametric
D015415:Biomarkers; D018836:Inflammation Mediators; D009195:Peroxidase