[The hematopoietic stem cell and the stromal microenvironment].
The hematopoietic system is the adult cellular model in which the biology of the stem cells is the best known and may be a model for numerous other tissues.  This model is theoretically based on a hierarchy of cells, which begin on a stem cell that differentiates into mature cells through a large number of cellular stages including hematopoietic progenitors.   Hematopoietic stem cells have three  ain properties: (1)  Self-renewal capacities.  However, in transplantation experiments this property is limited and may be regulated by the stem cell niche. (2)  Multipotentiality.  Hematopoietic stem cells are capable of differentiation towards all myeloid and lymphoid lineages.  However, recent experiments suggest that, like other somatic stem cells, hematopoietic stem cells are capable
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INSERM U 506, Hôpital Paul Brousse, 12 avenue Paul Vaillant Couturier, 94807 Villejuif, France.
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002450:Cell Communication; D002478:Cells, Cultured; D018920:Coculture Techniques; D005347:Fibroblasts / Q000166:cytology; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008264:Macrophages / Q000166:cytology; D051379:Mice; D017154:Stromal Cells / Q000166:cytology*