[Toxicity and hypotensive effect of L-arginine oxoborolidinone and its modulation by methylene blue. Comparison with L-arginine, nitrite, and nitrate].
Nitric oxide is synthesized by constitutive oxide nitric synthase from the guanidine group of L-arginine. L-arginine, oxoborolidinone of L-arginine, nitrite and nitrate showed dose-dependent hypotensive effects after injection via the femoral vein in Wistar rats. The hypotensive effects were shifted to the right after treatment with methylene blue, which is a synthetic phenothiazine inhibitor of guanylate cyclase. Oxoborolidinone of L-arginine had high hypotensive effects with an effective half dose of 10 eta moles kg-1 and of mumoles kg-1 for methylene blue. Methylene blue also attenuated the toxic effects of all the tested compounds.
Bravo Avila
M E
ME
Depto. de Bioquímica, Lab, de Bioquímica Médica I, Sección de Graduados, Escuela Superior de Medicina, IPN, Plan de San Luis y Díaz Mirón Casco de Santo Tomás, México D.F. C.P. 11340.
Araujo Alvarez
J M
JM
Bustamante Quezada
A
A
Trujillo Ferrara
J G
JG
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000633:toxicity*; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001896:Boron Compounds / Q000494:pharmacology*; D005260:Female; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology*; D009566:Nitrates / Q000494:pharmacology*; D009573:Nitrites / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D001896:Boron Compounds; D009566:Nitrates; D009573:Nitrites; D001120:Arginine; D008751:Methylene Blue