title: Immunity in the mammary gland.
abstract: The ruminant mammary gland is an extremely important economic organ in that it provides a major nutrition source for a significant portion of the world's human population. The ruminant mammary gland is also responsible for providing protective immunity to neonates and for defending itself from invading pathogens. A wide array of humoral and cellular immune mechanisms are present in the mammary gland and actively participate in providing immunity to newborns and the mammary gland per se. The acute inflammatory response is essential in determining the outcome of intramammary challenge, and factors affecting innate and adaptive immunity in the context of mammary health are reviewed in detail. The ruminant mammary gland is also unique in that lymphocyte trafficking, which is essential to adaptive immunity, is shared with the peripheral immune system rather than the common mucosal immune system.
authors.affiliation: Periparturient Diseases of Cattle Research Unit, National Animal Disease Center, US Department of Agriculture, Animal Research Service, Ames, Iowa, USA. kehrlm@pfizer.com
authors.forename: M E
authors.initials: ME
authors.lastname: Kehrli
authors.forename: J A
authors.initials: JA
authors.lastname: Harp
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000917:Antibody Formation; D002417:Cattle; D003126:Colostrum / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D008321:Mammary Glands, Animal / Q000276:immunology*; D008414:Mastitis, Bovine / Q000276:immunology / Q000382:microbiology; D008892:Milk / Q000166:cytology / Q000276:immunology* / Q000382:microbiology; D012418:Ruminants / Q000276:immunology*