title: [Primary angiitis of CNS (PACNS)].
abstract: Primary angiitis of the CNS (PACNS) is a rare inflammatory disease affecting middle-aged patients. The angiitis is focal and segmental in distribution, involving small and medium-sized leptomeningeal and intracranial vessels. The most frequent presenting symptoms are headaches, focal neurologic deficits, and confusion. In addition, aphasia, neuropsychological deficits, and seizures may occur. The paper presents a review of the literature. In addition, a typical case of PACNS is presented. This case demonstrates that diagnosis of PACNS is difficult and brain biopsy is essential to confirm it.
authors.affiliation: Medizinische Hochschule Hannover (MHH), Neurologische Klinik mit Klinischer Neurophysiologie, 30623 Hannover. rollnik.jens@mh-hannover.de
authors.forename: J D
authors.initials: JD
authors.lastname: Rollnik
authors.forename: A
authors.initials: A
authors.lastname: Brandis
authors.forename: K
authors.initials: K
authors.lastname: Dehghani
authors.forename: J
authors.initials: J
authors.lastname: Bufler
authors.forename: M
authors.initials: M
authors.lastname: Lorenz
authors.forename: F
authors.initials: F
authors.lastname: Heidenreich
authors.forename: F
authors.initials: F
authors.lastname: Donnerstag
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D002533:Cerebral Angiography; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome; D016896:Treatment Outcome; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone