Effects of pesticide exposure on serum immunoglobulin and complement levels.
Serum immunoglobulins (IgG, IgA and IgM), C3 and C4 complement protein levels were examined in the male workers of the municipality who routinely applied pesticides for at least one year, and compared to healthy male controls in order to determine whether immune alterations were evident in the pesticide-exposed workers. Pyrethroids were the most commonly used pesticides for the last 3 years. Serum immunoglobulins and complement levels were measured by turbidimetry. Serum IgG, IgA, IgM and C3 complement levels were found to be unchanged when compared to controls whereas a significant decrease was observed in serum C4 complement levels of the workers.
Undeğer
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Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey.
Başaran
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D000328:Adult; D016022:Case-Control Studies; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000172:deficiency / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010575:Pesticides / Q000009:adverse effects*
D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D010575:Pesticides; D003165:Complement System Proteins