title: Accumulation of metals in autopsy tissues of subjects living in Tarragona County, Spain.
abstract: The concentrations of arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), lead (Pb), manganese (Mn), mercury (Hg), nickel (Ni), tin (Sn), vanadium (V) and zinc (Zn) were determined in autopsy tissues collected from subjects who at the time of death had lived in Tarragona (Catalonia, Spain) over a period of, at least, the previous 10 years. Samples of liver, lung, kidney, brain and bone were obtained from a total of 78 non-occupationally exposed subjects, autopsied between 1997 and 1999. Arsenic, Cd, Co, Cr, Cu, Pb, Mn, Hg, Ni, Sn, V and Zn were determined by inductively coupled plasma spectrometry (ICP/MS). The results were analyzed with respect to age, sex, smoking and drinking habits, and the subject's place of residence. Most tissue concentrations of As, Co, Cr, Hg and V were near to the analytical detection limit or, in some cases, even below it. However, the levels of Cu were slightly higher than the average concentrations found in other studies. Also, tissue concentrations of Mn, Sn and Zn were similar to those found in previous surveys, while those of Ni were lower than previously reported. Although the current levels of tissue Cd and Pb were comparatively lower than in studies in other areas, the distribution of both metals was similar to previously-reported trends. From the tissue metal concentrations observed in the present study, it would appear that neither environmental exposure nor a dietary excess of these elements could be considered a health hazard to people living in the study area.
authors.affiliation: Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, Reus, Spain.
authors.forename: F
authors.initials: F
authors.lastname: García
authors.forename: A
authors.initials: A
authors.lastname: Ortega
authors.forename: J L
authors.initials: JL
authors.lastname: Domingo
authors.forename: J
authors.initials: J
authors.lastname: Corbella
mesh_terms: D000367:Age Factors; D001151:Arsenic / Q000493:pharmacokinetics*; D001344:Autopsy; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D019216:Metals, Heavy / Q000493:pharmacokinetics*; D008875:Middle Aged; D009928:Organ Specificity; D012737:Sex Factors; D013030:Spain; D014018:Tissue Distribution
chemical_list: D019216:Metals, Heavy; D001151:Arsenic