title: Proton chemical shift imaging in normal pressure hydrocephalus.
abstract: OBJECTIVE
  Differentiation of normal pressure hydrocephalus (NPH) from other types of dementia and the selection of appropriate candidates for shunt surgery remain a clinical challenge. The aims of this study were to assess the efficacy of cerebral metabolites depicted by proton chemical shift imaging (1H-CSI) in distinguishing NPH from other dementias and to examine the relationship between metabolite changes and the outcome of shunt surgery.
  
  
  METHODS
  1H-CSI measurements were obtained in nine patients with clinical diagnosis of NPH; six patients with other types of dementia, including Alzheimer and Pick disease; and five control subjects. The 1H-CSI sequence consisted of a double spin-echo sequence with imaging parameters of 2000/135/4-2 (TR/TE/acquisitions). Volumes of interest were selected from a section through the lateral ventricles. The peak areas and ratios of N-acetylaspartate, creatine, choline, and lactate were calculated. In two patients, follow-up 1H-CSI and N-isopropyl (123I)-p-iodoamphetamine brain perfusion imaging were available after treatment with continuous spinal drainage.
  
  
  RESULTS
  Lactate peaks were observed in the lateral ventricles for all patients with NPH (lactate/creatine, 0.23 +/- 0.14) but not for patients with other types of dementia or control subjects. In all cases, we noted no significant differences in the peak ratios in the voxels located at the white matter near the lateral ventricles. In one patient with NPH, intraventricular lactate disappeared and regional CBF recovered after drainage.
  
  
  CONCLUSIONS
  The intraventricular lactate level may be useful in differentiating NPH from other types of dementia.
authors.affiliation: Department of Radiology, Kyoto, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Kizu
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000175:diagnosis* / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008875:Middle Aged
chemical_list: D019344:Lactic Acid