Translocation t(4; 6)(q21; q27) in a case of primary thrombocythaemia in transformation.
We report a case of primary thrombocythaemia showing a translocation t(4; 6)(q21; q27) five years after diagnosis. The patient had been treated with hydroxyurea. The clinical picture at the time was consistent with transformation. Karyotypic abnormalities are rare in this disease and are reviewed.
Krsnik
I
I
Servicio de Hematología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain. ikrsnik@hupa.insalud.es
Ferro
T
T
García Suárez
J
J
Vázquez Mazariego
Y
Y
Cabello
P
P
D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4; D002896:Chromosomes, Human, Pair 6; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D007621:Karyotyping; D013920:Thrombocythemia, Essential / Q000188:drug therapy / Q000235:genetics*; D014178:Translocation, Genetic
D006918:Hydroxyurea