title: Blood transfusion and postoperative plasma cytokine antagonist levels in colorectal cancer patients.
abstract: OBJECTIVE
  Postoperative cytokine antagonist response affects various factors. However, excessive stress responses are deleterious as increased plasma concentration of cytokine antagonists may induce an impaired immune system.
  
  
  METHODS
  We determined plasma levels of cortisol, IL-1ra, and sTNF-R55 in 20 patients who had undergone resection of colorectal carcinoma. Ten patients had a blood transfusion during the operation (invasive group), but 10 patients had received no blood transfusion (less invasive group). Plasma levels of cytokine antagonists were determined before operation (POD 0) and POD-1, -2 and -7.
  
  
  RESULTS
  Postoperative plasma cortisol and sTNF-R55 levels were significantly elevated on POD-1 in the invasive group. Plasma IL-1ra levels were significantly increased on POD-1 in both the invasive and less invasive groups.
  
  
  CONCLUSIONS
  The present study demonstrated that perioperative allogeneic blood transfusion can induce an excessive production of cortisol and sTNF-R55, and might be deleterious.
authors.affiliation: First Department of Surgery, Okayama University Medical School, 2-5-1 Shikata, Okayama 700, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Iwagaki
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: N
authors.initials: N
authors.lastname: Urushihara
authors.forename: Y
authors.initials: Y
authors.lastname: Morimoto
authors.forename: A
authors.initials: A
authors.lastname: Jikuhara
authors.forename: H
authors.initials: H
authors.lastname: Isozaki
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D001803:Blood Transfusion; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000601:surgery; D016207:Cytokines / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology*; D011379:Prognosis; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D047888:Receptors, Tumor Necrosis Factor, Type I; D012795:Sialoglycoproteins / Q000097:blood
chemical_list: D015703:Antigens, CD; D016207:Cytokines; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D012795:Sialoglycoproteins; D006854:Hydrocortisone