title: The structure of microcarpalide, a microfilament disrupting agent from an endophytic fungus.
abstract: [structure: see text]. A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chirality method.
authors.affiliation: Department of Chemistry, University of Hawaii, 2545 McCarthy Mall, Honolulu, Hawaii 96822, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Ratnayake
authors.forename: W Y
authors.initials: WY
authors.lastname: Yoshida
authors.forename: S L
authors.initials: SL
authors.lastname: Mooberry
authors.forename: T
authors.initials: T
authors.lastname: Hemscheidt
mesh_terms: D008841:Actin Cytoskeleton / Q000187:drug effects*; D000475:Alkenes / Q000138:chemical synthesis*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D002942:Circular Dichroism; D005658:Fungi / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008856:Microscopy, Fluorescence; D008968:Molecular Conformation; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D007783:Lactones; C442268:oximidine I; C442267:oximidine II