title: Molecular Imprinting of Carboxylic Acids Employing Novel Functional Macroporous Polymers.
abstract: Imprinted network polymers incorporating basic functional groups were developed to assess the binding and specificity of carboxylic acids. The binding affinities were determined using t-BOC-phenylalanine and 2-phenylbutyric acid as templates and substrates. Chiral selectivity for the enantiomers of t-BOC-phenylalanine was found for polymers incorporating adenine or 2-aminopyridine functionality. Chiral selectivity in the case of (R)-(-)-2-phenylbutyric acid was found for the polymer utilizing N-(2-aminoethyl) methacrylamide as the functional monomer. Optimization of binding was achieved by changing polymerization conditions (thermal versus photochemical polymerization, monomer:template ratio) for t-BOC-phenylalanine imprinted polymers employing the N-(2-aminopyridine) methacrylamide monomer.
authors.affiliation: Department of Chemistry, University of California, Irvine, Irvine, California 92967-2025.
authors.forename: David
authors.initials: D
authors.lastname: Spivak
authors.forename: Kenneth J.
authors.initials: KJ
authors.lastname: Shea