title: Intravenous thyrotropin releasing hormone in amyotrophic lateral sclerosis: autonomic effects.
abstract: Heart rate, respiratory rate, systolic and diastolic blood pressure, and oral and skin temperature changes following intravenous administration of TRH occur at lower infusion rates in patients with ALS and bulbar involvement than in patients with ALS without bulbar involvement. This autonomic sensitivity to TRH infusion is characteristic of a more advanced stage of ALS with difficulties in speaking and swallowing. Patients who will be receiving neuropeptides, such as TRH, must be carefully studied to determine whether subclinical bulbar involvement is present. Such patients may require a lower initial dose or dose rate adjustment as well as continual monitoring during neuropeptide administration.
authors.affiliation: Neurology Department, University of Wisconsin School of Nursing, Madison, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Beaulieu
authors.forename: L
authors.initials: L
authors.lastname: Erickson
authors.forename: A
authors.initials: A
authors.lastname: Williams
authors.forename: R L
authors.initials: RL
authors.lastname: Sufit
authors.forename: B R
authors.initials: BR
authors.lastname: Brooks
mesh_terms: D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000503:physiopathology; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000188:drug therapy* / Q000503:physiopathology; D009460:Neurologic Examination / Q000187:drug effects; D016037:Single-Blind Method; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage*
chemical_list: D013973:Thyrotropin-Releasing Hormone