Primary sequences of proteinlike copolymers: Levy-flight-type long-range correlations.
We consider the statistical properties of primary sequences of two-letter HP copolymers (H for hydrophobic and P for polar) designed to have water soluble globular conformations with H monomers shielded from water inside the shell of P monomers. We show, both by computer simulations and by exact analytical calculation, that for large globules and flexible polymers such sequences exhibit long-range correlations which can be described by Levy-flight statistics.
Govorun
E N
EN
Physics Department, Moscow State University, Moscow 119899, Russia.
Ivanov
V A
VA
Khokhlov
A R
AR
Khalatur
P G
PG
Borovinsky
A L
AL
Grosberg
A Y
AY
D001703:Biophysics / Q000379:methods*; D003198:Computer Simulation; D008958:Models, Molecular; D015233:Models, Statistical; D008968:Molecular Conformation; D009010:Monte Carlo Method; D016012:Poisson Distribution; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D013816:Thermodynamics
D011108:Polymers