In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells.
The root of Paeonia suffruticosa ANDREWS is an important Chinese crude drug used in many traditional prescriptions. 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a major component of this crude drug, was found to exhibit in vitro growth-inhibiting effect on human hepatocellular carcinoma cell line, SK-HEP-1 cells. The growth-inhibitory effect was related to the ability of PGG not only to cause a G(0)/G(1) phase arrest but also to suppress the activation of nuclear factor-kappa B. Neither apoptosis nor necrosis was observed in the cells treated with PGG. These findings suggest that PGG could be a candidate for developing a low-toxic anticancer agent.
Oh
G S
GS
Medicinal Resources Research Center (MRRC) of Wonkwang University, Iksan, 570-749, Chonbuk, South Korea.
Pae
H O
HO
Oh
H
H
Hong
S G
SG
Kim
I K
IK
Chai
K Y
KY
Yun
Y G
YG
Kwon
T O
TO
Chung
H T
HT
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D024202:Electrophoretic Mobility Shift Assay; D016193:G1 Phase / Q000187:drug effects; D006801:Humans; D047348:Hydrolyzable Tannins; D016328:NF-kappa B / Q000378:metabolism; D009336:Necrosis; D016192:Resting Phase, Cell Cycle / Q000187:drug effects; D013634:Tannins / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D047348:Hydrolyzable Tannins; D016328:NF-kappa B; D013634:Tannins; C435084:pentagalloylglucose; D004247:DNA