title: [Spinal tuberculosis: early surgical treatment combined with medical treatment].
abstract: BACKGROUND
  Spinal tuberculosis can produce kyphosis with neurologicaldeficit, despite antibiotic treatment. When there is no response to medical treatment, the recommended procedure is debridementand interbody fusion with bone autograft. The biological characteristicsof Mycobacterium tuberculosis do not prevent osteosynthesisof the infected bone from being performed.
  
  
  METHODS
  Five patients with spinal tuberculosis and neurological deficitunderwent debridement, interbody fusion and anterior osteosynthesisin addition to medical treatment. In order to ensure stability, posterior fusion was also performed in three patients. All 5 patientsdisplayed weakness and paralysis of their lower extremities, two patients suffered an L4 radiculopathy, one developed paraparesiaand one was excluded due to a short follow-up. Mean value of vertebralkyphosis was 22,8 degrees and mean follow-up was 3,1 years.
  
  
  RESULTS
  No patient had septic loosening or progression of the disease. Correction of kyphosis was 104,5% postoperatively and 80,5% atthe end of follow-up. All patients, apart from one with an L4radiculopathy, exhibited neurological recovery.
  
  
  CONCLUSIONS
  Anterior instrumentation allows spinal decompression, septic focusdebridement, deformity correction and autologous bone grafting. In severe kyphotic flattening, it is advisable to associate alimited posterior arthrodesis. When pathological fractures appearor there is no response to antibiotic treatment, the combinationof medical and surgical treatment improves patients' outcome.
authors.affiliation: Servicio de Ortopedia y Traumatología, Institut Clínic de l'Aparell Locomotor, Hospital Clínic, Universitat de Barcelona, Spain. sfuster@med.ub.es
authors.forename: S
authors.initials: S
authors.lastname: Fuster
authors.forename: P
authors.initials: P
authors.lastname: Sala
authors.forename: S
authors.initials: S
authors.lastname: Prat
authors.forename: J
authors.initials: J
authors.lastname: Carles Martínez
authors.forename: J
authors.initials: J
authors.lastname: Colomer
authors.forename: S
authors.initials: S
authors.lastname: Suso
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014399:Tuberculosis, Spinal / Q000601:surgery* / Q000628:therapy