title: Synthesis and biological evaluation of azole derivatives, analogues of bifonazole, with a phenylisoxazolyl or phenylpyrimidinyl moiety.
abstract: A series of azole derivatives, isoxazole or pyrimidine analogues of the antifungal drug bifonazole, were synthesized and tested in vitro against representative human pathogenic fungi (Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus). They were also evaluated as antibacterial agents against Staphylococcus aureus and Salmonella spp. Only 5-(imidazol-1-yl-phenylmethyl)-2,4-diphenyl-pyrimidine 7c showed weak antimicrobial activity (MIC = 66 microM) against C. albicans, C. neoformans and S. aureus. Results of biological tests proved, therefore, that replacement of the biphenyl portion of the bifonazole with a phenylisoxazolyl or phenylpyrimidinyl moiety is not profitable for antimicrobial properties.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Genova, Italy. menozzi@unige.it
authors.forename: G
authors.initials: G
authors.lastname: Menozzi
authors.forename: L
authors.initials: L
authors.lastname: Mosti
authors.forename: P
authors.initials: P
authors.lastname: Fossa
authors.forename: C
authors.initials: C
authors.lastname: Musiu
authors.forename: C
authors.initials: C
authors.lastname: Murgioni
authors.forename: P
authors.initials: P
authors.lastname: La Colla
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D007093:Imidazoles; C036596:bifonazole