Possible clinically significant interaction of itraconazole plus rifampin.
We report two patients treated with the combination of itraconazole plus rifampin for more than 4 months. While on itraconazole plus rifampin, patient 1 lost weight at a rate of 30 g/d. After stopping rifampin, he gained 14 g/d. While on itraconazole plus rifampin, patient 2 lost 41 grams/day. After stopping rifampin, he gained 33 g/d. Weight loss while taking the combination of itraconazole plus rifampin, followed by weight gain after stopping rifampin, suggests the possibility of a clinically significant drug interaction between itraconazole and rifampin.
Todd
J R
JR
Department of Medicine, Section of Infectious Disease, Louisiana State University Medical Center in Shreveport, Shreveport, Louisiana 71130-3932, USA. jtodd@lsuhsc.edu
Arigala
M R
MR
Penn
R L
RL
King
J W
JW
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D000935:Antifungal Agents / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006660:Histoplasmosis / Q000188:drug therapy; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy; D012293:Rifampin / Q000009:adverse effects*; D015431:Weight Loss
D000904:Antibiotics, Antitubercular; D000935:Antifungal Agents; D017964:Itraconazole; D012293:Rifampin