title: Spatio-temporal expression of a gene encoding a putative RNA-binding protein during the early larval development of the mollusc Patella vulgata.
abstract: In the mollusc Patella vulgata a cDNA clone named Esther 32 (E32) was found to be expressed in a specific spatio-temporal pattern. DNA sequence analysis showed that E32 represents a putative RNA-binding protein containing a KH domain. In early trochophore larvae, expression of E32 was found in all cells except the already differentiated trochoblasts and the apical tuft cells. Later on in development, expression was also abolished in the presumptive shell gland and restricted to specific areas, among which were the head and foot anlage. This suggests that E32 is involved in maintaining cells in an undifferentiated state via a post-transcriptional mechanism.
authors.affiliation: Department of Vascular Medicine, G1-114, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. A.Klerkx@amc.uva.nl
authors.forename: A H
authors.initials: AH
authors.lastname: Klerkx
authors.forename: E
authors.initials: E
authors.lastname: de Boer
authors.forename: A E
authors.initials: AE
authors.lastname: van Loon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D003001:Cloning, Molecular; D004625:Embryo, Nonmammalian / Q000187:drug effects / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D006801:Humans; D017403:In Situ Hybridization; D007814:Larva / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D008969:Molecular Sequence Data; D008974:Mollusca / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development*; D008985:Monensin / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D008985:Monensin