title: Synthesis of griseolic acid B by pi-face-dependent radical cyclization.
abstract: [reaction: see text]. Radical cyclization of 6 affords the bicyclic vinyl ether 9 with the appropriate stereochemistry for elaboration (seven steps) to griseolic acid B (1).
authors.affiliation: Department of Chemistry & Chemical Biology, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854-8087, USA. knapp@rutchem.rutgers.edu
authors.forename: S
authors.initials: S
authors.lastname: Knapp
authors.forename: M R
authors.initials: MR
authors.lastname: Madduru
authors.forename: Z
authors.initials: Z
authors.lastname: Lu
authors.forename: G J
authors.initials: GJ
authors.lastname: Morriello
authors.forename: T J
authors.initials: TJ
authors.lastname: Emge
authors.forename: G A
authors.initials: GA
authors.lastname: Doss
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D003500:Cyclization; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D010726:Phosphodiesterase Inhibitors; C056334:griseolic acid B; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000241:Adenosine