GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis.
Eight patients with Rasmussen's encephalitis, 40 patients with noninflammatory focal epilepsy, 104 patients with various neurologic diseases, and 16 healthy donors were tested for the prevalence of antibodies against the GluR3 receptor in serum and CSF. Reactivities against different peptides derived from various portions of this glutamate receptor subtype were detectable in a significantly higher number of patients with focal epilepsy than in those with other neurologic diseases, but they were not specific for the diagnosis of Rasmussen's encephalitis.
Wiendl
H
H
Department of Neurology, University of Tübingen, Germany. heinz.wiendl@uni-tuebingen.de
Bien
C G
CG
Bernasconi
P
P
Fleckenstein
B
B
Elger
C E
CE
Dichgans
J
J
Mantegazza
R
R
Melms
A
A
D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood; D002648:Child; D004660:Encephalitis / Q000453:epidemiology* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D004827:Epilepsy / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D018091:Receptors, AMPA / Q000737:chemistry / Q000276:immunology*; D016036:Seroepidemiologic Studies
D001323:Autoantibodies; D018091:Receptors, AMPA; C104723:glutamate receptor ionotropic, AMPA 3