title: Clinical effect of etidronate on alveolar pyorrhoea associated with chronic marginal periodontitis: report of four cases.
abstract: Etidronate 200 mg daily was administered to four female patients with periodontitis and resultant alveolar pyorrhoea for periods of 2 weeks, followed by off-periods of 10 weeks or more, for 2-3 years. The macroscopic appearance of gingival mobility of the teeth, depth of periodontal pockets, and X-ray findings of alveolar bones improved markedly during this time. The effects were first observed after 6-12 months of treatment. These findings indicate that bisphosphonates may be effective in the treatment of periodontitis and resultant alveolar pyorrhoea. The effect may be mediated by the inhibitory action on bone resorption and the anti-inflammatory action of etidronate. Concomitant conventional dental management is also required.
authors.affiliation: Takaishi Dental Clinic, Himeji, Japan. takaishi@dentalgraphic.com
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: T
authors.initials: T
authors.lastname: Miki
authors.forename: Y
authors.initials: Y
authors.lastname: Nishizawa
authors.forename: H
authors.initials: H
authors.lastname: Morii
mesh_terms: D001862:Bone Resorption / Q000188:drug therapy / Q000473:pathology; D012968:Etidronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D010518:Periodontitis / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D014086:Tooth Mobility / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
chemical_list: D012968:Etidronic Acid