title: Multiport flow-control system for lab-on-a-chip microfluidic devices.
abstract: A multiport system suitable for pressure control on a lab-on-a-chip microfluidic device is described. An algorithm and a strategy for calculating pressures were developed to control the flow from multiple reservoirs for the microfluidic devices. Dye mixing and enzyme assay titration experiments were performed using pressure-driven flow only. Results show a good linear response over two orders of dynamic range.
authors.affiliation: Caliper Technologies Corp, Mountain View, CA 94043, USA. ring-ling.chien@calipertech.com
authors.forename: R L
authors.initials: RL
authors.lastname: Chien
authors.forename: J W
authors.initials: JW
authors.lastname: Parce
mesh_terms: D000465:Algorithms; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004798:Enzymes / Q000378:metabolism*; D004867:Equipment Design; D005456:Fluorescent Dyes / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008832:Microchemistry / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D008856:Microscopy, Fluorescence; D011312:Pressure; D012212:Rheology
chemical_list: D004798:Enzymes; D005456:Fluorescent Dyes; D000469:Alkaline Phosphatase