title: [High dosage brachytherapy and external irradiation of localized prostate carcinoma--results at the Kiel University Clinic].
abstract: To evaluate a new therapy protocol for local dose escalation by high dose rate (HDR) brachytherapy for survival, morbidity and prognostic variables in men with localized prostate cancer. The prospectively recorded files of 189 men aged in median 69 years with a mean follow-up of 6 years (12-143 months) receiving curatively intended combined high dose rate (HDR) 192-iridium-brachytherapy (BT) and external beam radiation (EBR) for locally confined prostate cancer were analyzed. Mean age was 68.2 (range 44-84 years). Hundred and twenty-seven patients had T1-2 tumors, and 62 patients had T3-tumors. The total planned dose applied by external beam radiation was 50 Gy in the pelvis, and 40 Gy in the prostate by in-field-dose modification. The HDR-brachytherapy was delivered in two fractions. The dose per fraction amounted 15 Gy. Mean survival was 6 years (range 12-143 months), 76.7% of the patients survived and 86.3% were disease-free. The biochemical non-evidence of disease rate (BNED) was 78%. Univariate survival analysis revealed that low stage (T1-2), low grade (G1-2), normal PSA status after radiation therapy, and no adjuvant hormonal treatment were associated with long survival. However, the stratification for adjuvant hormonal treatment was not according to random. In multivariate analyses PSA status was an independent prognostic factor. The six year results confirm that local dose escalation by HDR-brachytherapy and external beam radiation is curative in men with locally confined prostate cancer. The results are especially in high risk patients encouraging.
authors.affiliation: Interdisziplinäres Brachytherapiezentrum, Klinik für Strahlentherapie und Radioonkologie, Kiel.
authors.forename: G
authors.initials: G
authors.lastname: Kovács
authors.forename: R
authors.initials: R
authors.lastname: Galalae
authors.forename: T
authors.initials: T
authors.lastname: Loch
authors.forename: P
authors.initials: P
authors.lastname: Rzehak
authors.forename: R
authors.initials: R
authors.lastname: Wilhelm
authors.forename: H
authors.initials: H
authors.lastname: Bertermann
authors.forename: N
authors.initials: N
authors.lastname: Nürnberg
authors.forename: P
authors.initials: P
authors.lastname: Kohr
authors.forename: B
authors.initials: B
authors.lastname: Kimmig
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D005500:Follow-Up Studies; D005858:Germany; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D011882:Radiotherapy, High-Energy; D015996:Survival Rate