Insulin sensitivity with respect to glucose metabolism in hypertension-prone men did not predict the blood pressure increase in 5 years.
OBJECTIVE
To evaluate peripheral insulin stimulated glucose uptake as a predictor for increase in blood pressure in hypertension-prone men.


METHODS
A follow-up study 5 years after a primary investigation that included an euglycaemic hyperinsulinaemic clamp to evaluate insulin sensitivity.


METHODS
Thirty-two men with a family history of hypertension (relatives) and 22 men with no hypertension in the family (controls). All were normotensive and had a normal glucose tolerance.


METHODS
Change in blood pressure over 5 years and its relation to the values obtained in the basal investigation.


RESULTS
Systolic and diastolic blood pressure increased in both groups during the 5 years, but diastolic blood pressure increased more in relatives than in controls (11 mm Hg vs 5 mm Hg, P = 0.03). The change in diastolic blood pressure was correlated to basal BMI (r = 0.43, P = 0.02) only in controls. There were no correlations between the change in blood pressure during the 5 years and basal glucose disposal nor to any of the other basal parameters in either relatives or controls.


CONCLUSIONS
Insulin sensitivity did not predict the change in blood pressure during the 5 years either in hypertension-prone men or in controls, nor did anthropometrical measurements, basal and stimulated insulin and maximal oxygen uptake. The blood pressure increase was related to basal BMI only in controls.
Mattiasson
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Department of Medicine, Malmö University Hospital, S-20502 Malmö, Sweden. ingrid.mattiasson@medforsk.mas.lu.se
Endre
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Hulthén
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UL
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D005192:Family Health; D005500:Follow-Up Studies; D015309:Glucose Clamp Technique; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
D001786:Blood Glucose; D000450:Aldosterone; D010100:Oxygen