title: Enzymatic Lactonization Stategy for Enantioselective Synthesis of a Tetrahydrolipstatin Synthon.
abstract: A novel lipase-catalyzed protocol has been formulated for the simultaneous enantiocontrol of three stereogenic centers in a flexible acyclic system. This involved a porcine pancreatic lipase (PPL)-catalyzed delta-lactonization of a racemic 3,5-dihydroxy-2-alkyl ester to produce the lactone with high enantioselectivity (92.8%). The product lactone and its analogues are useful synthons for the asymmetric synthesis of various bioactive compounds, which include the potential anti-obesity compound, tetrahydrolipstatin.
authors.affiliation: Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
authors.forename: A.
authors.initials: A
authors.lastname: Sharma
authors.forename: S.
authors.initials: S
authors.lastname: Chattopadhyay