title: HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other.
abstract: Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV-1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV-1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzymes within the HIV-1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV-1 replication within the target cells.
authors.affiliation: Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Zurich, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Tasara
authors.forename: G
authors.initials: G
authors.lastname: Maga
authors.forename: M O
authors.initials: MO
authors.lastname: Hottiger
authors.forename: U
authors.initials: U
authors.lastname: Hübscher
mesh_terms: D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D019427:HIV Integrase / Q000737:chemistry / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000378:metabolism; D016325:HIV Long Terminal Repeat; D054303:HIV Reverse Transcriptase / Q000737:chemistry / Q000378:metabolism*; D015497:HIV-1 / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000378:metabolism; D014779:Virus Replication / Q000502:physiology
chemical_list: D004279:DNA, Viral; D019428:HIV Integrase Inhibitors; D018894:Reverse Transcriptase Inhibitors; D019427:HIV Integrase; D054303:HIV Reverse Transcriptase