Radiation induced vertebral osteosarcoma following treatment of an intradural extramedullary spinal cord tumor in a dog.
A 2-year-old neutered female Rottweiler diagnosed with an intradural extramedullary spinal cord tumor at T12-T13 was successfully treated with cytoreductive surgery followed by Cobalt 60 teletherapy. The dog was euthanised 5-and-a-half years later following diagnosis of an osteosarcoma involving the L1 and L2 vertebrae. Evidence of the initial tumor was not present at necropsy. The vertebral neoplasm fulfilled all of the accepted criteria for a radiation induced tumor. It was concluded that adjunctive irradiation should be considered for treatment of intradural extramedullary tumors of young dogs when total surgical resection is not possible. Although tumor induction is a rare late effect of radiation therapy, the risk of this occurrence should be considered when irradiating young animals. Radiation induced tumors in dogs have been associated with coarse fractionation schemes, or when large intraoperative doses have been administered. A lower dose per fraction, e.g., 3 Gy/fraction or less, is advisable when irradiating young dogs or any dog in which the life expectancy is 3-5 or more years after irradiation.
Dickinson
P J
PJ
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
McEntee
M C
MC
Lipsitz
D
D
Keel
K
K
LeCouteur
R A
RA
D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs; D005260:Female; D007794:Lameness, Animal / Q000209:etiology; D008159:Lumbar Vertebrae; D009381:Neoplasms, Radiation-Induced / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D012516:Osteosarcoma / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D013120:Spinal Cord Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000662:veterinary*; D013125:Spinal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D013904:Thoracic Vertebrae