Results of 6139 artificial insemination cycles with donor spermatozoa.
BACKGROUND
Artificial insemination by donor spermatozoa (AID) can prove a valuable treatment for a number of male factor disorders, although its success rate is variable.


METHODS
Retrospective analysis of the results of 6139 cycles performed in 1001 women during an 18 year period is presented. Pregnancy rates per cycle are presented as a function of: female fertility history, treatment modalities, medication used for induction of ovulation, female age, year of treatment, consecutive cycle effect and the use of fresh versus frozen-thawed spermatozoa.


RESULTS
Overall pregnancy rate of 12.6% and cumulative pregnancy rate after 12 months of treatment of 75% were achieved. Age was found to be the most important determinant for success rate.


CONCLUSIONS
Since the establishment of AID treatments, the mean age of the population of women receiving treatment has increased each year. Consequently, success rate did not improve, even with the use of more sophisticated medical modalities.
Botchan
A
A
Institute for the Study of Fertility, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel. amnonbb@inter.net.il
Hauser
R
R
Gamzu
R
R
Yogev
L
L
Paz
G
G
Yavetz
H
H
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000013:Congenital Abnormalities / Q000453:epidemiology; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy; D007316:Insemination, Artificial, Heterologous; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012189:Retrospective Studies; D012662:Semen Preservation; D014019:Tissue Donors; D016896:Treatment Outcome