title: Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice.
abstract: Mangifera indica Linn, a plant widely used in the traditional medicinal systems of India, has been reported to possess antiviral, antibacterial and anti-inflammatory activities. In the present study, the alcoholic extract of stem bark of Mangifera indica Linn (Extract I containing mangiferin 2.6%), has been investigated for its effect on cell mediated and humoral components of the immune system in mice. Administration of test extract I produced increase in humoral antibody (HA) titre and delayed type hypersensitivity (DTH) in mice. It is concluded that test extract I is a promising drug with immunostimulant properties.
authors.affiliation: Poona College of Pharmacy, Bharati Vidyapeeth (Deemed University), Erandwane, 411 038, Pune, India.
authors.forename: N
authors.initials: N
authors.lastname: Makare
authors.forename: S
authors.initials: S
authors.lastname: Bodhankar
authors.forename: V
authors.initials: V
authors.lastname: Rangari
mesh_terms: D000276:Adjuvants, Immunologic / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003520:Cyclophosphamide / Q000276:immunology / Q000494:pharmacology; D005260:Female; D006968:Hypersensitivity, Delayed; D007166:Immunosuppressive Agents / Q000276:immunology / Q000494:pharmacology; D007194:India; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D010936:Plant Extracts / Q000276:immunology* / Q000494:pharmacology; D014966:Xanthenes / Q000276:immunology* / Q000494:pharmacology; D044004:Xanthones
chemical_list: D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin; D003520:Cyclophosphamide