Palatal development in Twirler mice.
OBJECTIVE
The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygous mutant embryos was conducted.


CONCLUSIONS
The secondary palatal shelves were retarded in growth and the timing of elevation from a vertical to horizontal position. The homozygous Tw embryos, when compared with their wild-type littermates, also had a significantly wider midface. It is not surprising, therefore, that the short palatal shelves in a wide midface resulted in cleftings of the secondary palate observed in all homozygous Tw mice. These findings are consistent with similar studies in humans and other murine models.
Gong
S G
SG
Department of Orthodontics and Pediatric Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109-1078, USA. sggong@umich.edu
Eulenberg
R L
RL
D000818:Animals; D002508:Cephalometry; D002972:Cleft Palate / Q000196:embryology*; D004396:Coloring Agents; D004195:Disease Models, Animal; D004622:Embryo, Mammalian; D005314:Embryonic and Fetal Development; D004801:Eosine Yellowish-(YS); D005456:Fluorescent Dyes; D005865:Gestational Age; D006416:Hematoxylin; D006720:Homozygote; D007091:Image Processing, Computer-Assisted; D051379:Mice; D008817:Mice, Mutant Strains; D010159:Palate / Q000196:embryology*; D012886:Skull / Q000196:embryology; D013223:Statistics as Topic
D004396:Coloring Agents; D005456:Fluorescent Dyes; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin