title: Diastereoselective and Enantioselective Intramolecular Amino-Zinc-Enolate Carbometalation Reactions. A New Polysubstituted Pyrrolidines Synthesis.
abstract: The amino-zinc-enolate cyclization allowed a new and straightforward route to polysubstituted pyrrolidines from simple starting materials. From this study, we have been able to determine, for the first time, the stereochemical influence of the substituents on the ring in the carbocyclization reaction. The diastereoselectivity thus obtained was explained by a chairlike amino-zinc-enolate transition state.
authors.affiliation: Laboratoire de Chimie des Organoéléments, Université P. et M. Curie, 4 Place Jussieu, 75252 Paris Cedex 05-France.
authors.forename: Edwige
authors.initials: E
authors.lastname: Lorthiois
authors.forename: Ilane
authors.initials: I
authors.lastname: Marek
authors.forename: Jean F.
authors.initials: JF
authors.lastname: Normant