Gliomas arising in organ transplant recipients: an unrecognized complication of transplantation?
Reported are six cases of glioma, diagnosed in the last 10 years, arising in organ transplant recipients. Five transplant recipients developed glioblastoma, and one developed oligodendroglioma. None had other risk factors for glioma. Gliomas must be considered in the differential diagnosis of space-occupying lesions in transplant recipients. Although these cases may represent coincidence, the putative HIV-glioma association suggests a pathogenetic link to immunosuppression.
Schiff
D
D
Department of Neurological Surgery, University of Pittsburgh Medical Center, PA 15213, USA. schiffd@msx.upmc.edu
O'Neill
B
B
Wijdicks
E
E
Antin
J H
JH
Wen
P Y
PY
D000368:Aged; D001932:Brain Neoplasms / Q000209:etiology*; D005260:Female; D005910:Glioma / Q000209:etiology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*