Three new derivatives of 3-amino-1,2-propanediol; their spectral properties and biological evaluation.
Three new derivatives of 3-amino-1,2-propanediol have been synthesized. Full assignments of signals in their 1H- and 13C-NMR spectra are given. The influence of these compounds on the cardiovascular system in the anaesthetized rat was examined. In contrast to CGP 12177 which induced a strong increase in heart rate and a slight increase in blood pressure, compounds 1, 2 and 3 x HCl at doses up to 1 micromol/kg and compound 3 at doses of 0.01 and 0.1 micromol/kg did not change the cardiovascular parameters. The highest dose of compound 3-1 micromol/kg caused a very short-lasting decrease in heart rate (by 14%) and in blood pressure (by 25%).
Morzycki
J W
JW
Institute of Chemistry, University of Białystok, Poland. morzycki@noc.uwb.edu.pl
Maj
J
J
Nikitiuk
A
A
Kwolek
G
G
Malinowska
B
B
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D011412:Propanolamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats
D002317:Cardiovascular Agents; D011412:Propanolamines; C063408:1-aminopropanediol; C033394:CGP 12177