title: [Local excision with postoperative radiotherapy for T2 or T3 distal rectal cancer. Long-term results].
abstract: OBJECTIVE
  To evaluate, in a prospective study of a cohort of patients, the local recurrence rate of T2 or T3 rectal cancers treated by transanal excision after preoperative irradiation.
  
  
  METHODS
  Between 1992 and 1999, 34 patients were treated after radiotherapy by a local excision for a distal rectal carcinoma limited to (stage T2) or invading through the muscular layer (stage T3). Four patients were excluded either for palliative treatment or lost for follow-up. Thirty patients were included in the study (8 uT2, 8 uT3, 14 undetermined preirradiation stage).
  
  
  RESULTS
  After a 74-month mean follow-up (median: 46), the 5-year local recurrence rate was 33%. Even among subgroups of patients with a significant risk factor for local recurrence (size > 40 mm, clear margin < 2 mm, uT3 stage versus uT2) there were no benefits from irradiation.
  
  
  CONCLUSIONS
  Local excision of T2 or T3 rectal cancers is associated with an elevated local recurrence rate. This result is demonstrated even after adjunction of a preoperative irradiation. So, local treatment must be restricted to clearly informed patients who definitively refuse a radical intervention.
authors.affiliation: Service de coloproctologie, maison de santé protestante Bagatelle, 33401 Talence, France. proctobagatelle@mspb.com
authors.forename: F
authors.initials: F
authors.lastname: Pigot
authors.forename: M
authors.initials: M
authors.lastname: Dernaoui
authors.forename: A
authors.initials: A
authors.lastname: Castinel
authors.forename: F
authors.initials: F
authors.lastname: Juguet
authors.forename: J C
authors.initials: JC
authors.lastname: Chaume
authors.forename: J
authors.initials: J
authors.lastname: Faivre
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D012307:Risk Factors; D016896:Treatment Outcome