title: Using Hydrogen Bonding to Control Carbamate C-N Rotamer Equilibria.
abstract: In chloroform solution, the syn/anti rotamer ratios for N-(2-pyridyl)carbamates, 3, and N-phenylcarbamates, 4, are close to 0.05. Addition of the double hydrogen bonding acetic acid moderately stabilizes the syn rotamer of 4, but has no measurable effect on the syn/anti ratio for 3. Conversely, the hydrogen bond donor-acceptor-donor triad in 2,6-bis(octylamido)pyridine, 1, strongly stabilizes the syn rotamer of 3, but has no effect on the syn/anti ratio for 4. The K(a) for syn-3:1 is 10(3)-10(4) times higher than the K(a) for anti-3:1. This implies that the alkoxy oxygen in anti-3 is a much poorer hydrogen bond acceptor than the carbonyl oxygen in syn-3, most likely because of a combination of steric and electrostatic factors.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46656.
authors.forename: Alexei L.
authors.initials: AL
authors.lastname: Moraczewski
authors.forename: Laura A.
authors.initials: LA
authors.lastname: Banaszynski
authors.forename: Aaron M.
authors.initials: AM
authors.lastname: From
authors.forename: Courtney E.
authors.initials: CE
authors.lastname: White
authors.forename: Bradley D.
authors.initials: BD
authors.lastname: Smith