Nutritional factors and Alzheimer's disease.
Nutritional factors are integrally linked with Alzheimer's disease (AD). Although AD patients have no changes in energy metabolism, fluctuations in weight are fairly common. The potential role of vitamin B(12) and folate, with the production of hyperhomocysteinemia, in the pathophysiology of AD is explored. The role of free-radical damage in AD is discussed. It is stressed that alterations in dietary lipids may play an important role in cognitive defects in AD secondary to their effects on neuronal membrane lipids. More research is needed on the role of nutrition in the ongoing development of cognitive changes in AD.
Reynish
W
W
Department of Clinical Gerontology and Internal Medicine, University Hospital of Toulouse, France.
Andrieu
S
S
Nourhashemi
F
F
Vellas
B
B
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D001361:Avitaminosis / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D004734:Energy Metabolism; D006801:Humans; D066298:In Vitro Techniques; D009747:Nutritional Physiological Phenomena; D009752:Nutritional Status; D018384:Oxidative Stress; D015431:Weight Loss
D016564:Amyloid beta-Protein Precursor; D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D002784:Cholesterol