title: Influence of preservation solution on early graft failure in clinical lung transplantation.
abstract: The aim of this study was to assess the influence of preservation solution type and extra- or intracellular composition on the occurrence of early graft dysfunction after clinical lung transplantation. For 170 patients who underwent a single (n = 124) or bilateral (n = 46) lung transplantation in two centers in Paris between 1988 and 1999, the preservation technique applied to the donor lung was single-flush perfusion of the pulmonary artery with one of several solutions of intracellular (Euro-Collins, n = 61; University of Wisconsin, n = 24) or extracellular composition (Cambridge, n = 64; Celsior, n = 21). The early postoperative outcome of these patients was reviewed. Reimplantation edema occurred in 48% of all patients, and the overall 1-mo survival rate was 84%. No significant difference in the incidence of edema, duration of mechanical ventilation, and 1-mo survival rate was observed between the four groups or between intra- and extracellular groups. After adjustment for graft ischemic time by means of multivariate analysis, the use of extracellular preservation fluid was associated with a lower incidence of reimplantation edema without effect on 1-mo mortality. Graft ischemic time was associated with both edema occurrence and 1-mo survival rate (p = 0.02 and p = 0.01, respectively). We conclude that extracellular-type solutions are associated with better lung preservation than intracellular-type solutions in clinical transplantation.
authors.affiliation: Service de Pneumologie et Réanimation Respiratoire, Hôpital Beaujon, Clichy, France.
authors.forename: G
authors.initials: G
authors.lastname: Thabut
authors.forename: I
authors.initials: I
authors.lastname: Vinatier
authors.forename: O
authors.initials: O
authors.lastname: Brugière
authors.forename: G
authors.initials: G
authors.lastname: Lesèche
authors.forename: P
authors.initials: P
authors.lastname: Loirat
authors.forename: A
authors.initials: A
authors.lastname: Bisson
authors.forename: J
authors.initials: J
authors.lastname: Marty
authors.forename: M
authors.initials: M
authors.lastname: Fournier
authors.forename: H
authors.initials: H
authors.lastname: Mal
mesh_terms: D005260:Female; D006084:Graft Rejection / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D019188:Organ Preservation Solutions; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D019188:Organ Preservation Solutions