Effect of intravenous injection of DAGO on neuronal activity in bulbar cardiovascular center.
Effects of intravenous injection of DAGO on impulse neuronal activity of the bulbar cardiovascular center were studied in acute experiments on cats narcotized with Nembutal. DAGO-induced changes in activity of sensory neurons and interneurons were unidirectional and preceded hemodynamic shifts. The antiarrhythmic effect of DAGO is due to its direct action on neurons of the bulbar cardiovascular center.
Mikhailova
S D
SD
Russian State Medical University, Moscow. al_sokolov@memo.ru
Sokolov
A V
AV
Semushkina
T M
TM
Storozhakov
G I
GI
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D004562:Electrocardiography; D004594:Electrophysiology; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology*; D007275:Injections, Intravenous; D007395:Interneurons / Q000187:drug effects / Q000378:metabolism; D008526:Medulla Oblongata / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism
D000701:Analgesics, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-