Axinellamines A-D, Novel Imidazo-Azolo-Imidazole Alkaloids from the Australian Marine Sponge Axinella sp.
Four imidazo-azolo-imidazole alkaloids, axinellamines A-D, have been isolated from an Australian marine sponge, Axinella sp. (order: Halichondrida: family: Axinellidae). These compounds contain a unique perhydrocyclopenta-imidazo-azolo-imidazole carbon skeleton. Three of these compounds had bactericidal activity against Helicobacter pylori at 1000 &mgr;M.
Urban
Sylvia
S
Queensland Pharmaceutical Research Institute, Griffith University, Brisbane, Queensland 4111, Australia, and Queensland Museum, South Brisbane, Queensland 4101, Australia.
de Almeida Leone
Priscila
P
Carroll
Anthony R.
AR
Fechner
Gregory A.
GA
Smith
Jill
J
Hooper
John N. A.
JN
Quinn
Ronald J.
RJ