title: Oral glucose solution for analgesia in infant circumcision.
abstract: OBJECTIVE
  Our objectives were to determine if a 50% dextrose solution would reduce the percentage of circumcision procedure time a neonate spent crying by 50% compared with water and whether it would be similar to a dorsal penile nerve block (DPNB).
  
  
  METHODS
  This was a randomized placebo-controlled blinded clinical trial.
  
  
  METHODS
  We included 71 patients who were recruited from the inpatient nursery of a military community hospital over a 5-month period.
  
  
  METHODS
  The primary outcome was the percentage of the procedure time neonates spent crying. Secondary outcomes were the percentage change in heart rate from baseline, the percentage of oxygen saturation, and the score from the modified behavioral pain scale.
  
  
  RESULTS
  There were no significant differences between the oral glucose and water groups among any of the pain-related measurements. The DPNB group had significantly lower pain-related measurements (P &lt.05).
  
  
  CONCLUSIONS
  Concentrated glucose administered orally does not provide significant analgesia in neonatal circumcision. The use of DPNB significantly reduced objective measurements of pain and physiologic stress in infants undergoing circumcision.
authors.affiliation: Headquarters Battalion, BAS, Camp Lejeune, CA, USA.
authors.forename: F C
authors.initials: FC
authors.lastname: Kass
authors.forename: J R
authors.initials: JR
authors.lastname: Holman
mesh_terms: D000284:Administration, Oral; D000698:Analgesia; D002944:Circumcision, Male; D003448:Crying; D005947:Glucose / Q000008:administration & dosage / Q000627:therapeutic use*; D006339:Heart Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010092:Oximetry
chemical_list: D005947:Glucose