Coordination Chemistry of the Carboxylate Type Siderophore Rhizoferrin: The Iron(III) Complex and Its Metal Analogs.
Rhizoferrin is a member of a new class of siderophores (microbial iron transport compounds) based on carboxylate and hydroxy donor groups rather than the commonly encountered hydroxamates and catecholates. We have studied the coordination chemistry of rhizoferrin (Rf), as a representative of this group, with Fe(3+), Rh(3+), Cr(3+), Al(3+), Ga(3+), VO(2+), and Cu(2+). The metal complexes have been studied by UV-vis, CD, NMR, and EPR spectroscopies and mass spectrometry. The formation constants for the iron complex have also been measured and yield a log K(LFe) of 25.3. The Rh and Cr rhizoferrin complexes are unusual in that they appear to adopt a chirality about the metal center that is the opposite of the native iron analog. Several of the alternative metal ion complexes are found to have biological activity toward Morganella morganii in a plate type assay.
Carrano
Carl J.
CJ
Microbiology and Biotechnology, University of Tübingen, Auf der Morgenstelle 1, 72076 Tübingen, Germany, Organic Chemistry 1, University of Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany, and Laboratoire de Physico-Chimie Bioinorganique, EHICS, 1 rue Blaise Pascal, 67000 Strasbourg, France.
Drechsel
Hartmut
H
Kaiser
Dietmar
D
Jung
Günther
G
Matzanke
Berthold
B
Winkelmann
Günther
G
Rochel
Natacha
N
Albrecht-Gary
Anne Marie
AM