title: Synthesis of 1-Amino-3-[2-(1,7-dicarba-closo-dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic Acid: A Potential BNCT Agent.
abstract: The synthesis of an unnatural amino acid, 1-amino-3-[2-(1,7-dicarba-closo-dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic acid, was achieved. This new potential BNCT agent was prepared via the monoalkylation of m-carborane with 4-bromobutene to produce 4-m-carboranyl-1-butene, which was then subjected to a 2 + 2 cycloaddition using dichloroketene. The resultant boronated cyclobutanone was reductively dechlorinated prior to the formation of the corresponding hydantoin, which was hydrolized to the title compound in excellent yield.
authors.affiliation: Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee 37996-1600.
authors.forename: Rajiv R.
authors.initials: RR
authors.lastname: Srivastava
authors.forename: Robert R.
authors.initials: RR
authors.lastname: Singhaus
authors.forename: George W.
authors.initials: GW
authors.lastname: Kabalka