A new class of antiarrhythmic-defibrillatory agents.
Novel dibenzoazepine and 11-oxo-dibenzodiazepine derivatives are shown to be effective ventricular defibrillating drug candidates. They exhibit significant in vivo defibrillatory activity with no observed changes in ECG either before or after the VF event. These compounds also exhibit antifibrillatory activity by elevating the fibrillation threshold potential, all suggesting that such drugs could be used to treat VF either by themselves or together with electrical defibrillators.
Levy
O
O
Department of Chemistry and Institute of Catalysis Science and Technology, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel.
Erez
M
M
Varon
D
D
Keinan
E
E
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000627:therapeutic use*; D002415:Cats; D003984:Dibenzazepines / Q000138:chemical synthesis / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D014693:Ventricular Fibrillation / Q000188:drug therapy*
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines