Metabolite ratios measured with a short echo time 1H-MRS in the frontal lobe of young healthy subjects: an approach to generate reference 1H-MRS data.
Proton magnetic resonance spectroscopy (1H-MRS) performed with a semi-automated Elscint Prestige 2 Tesla tomograph/spectroscope was used to determine the ratios of the most prominent resonances recorded from the 2 x 2 x 2 cm voxels located in the frontal lobe of healthy young males and females. The values of major metabolite ratios (NAA/Cr, Cho/Cr and ml/Cr) were normally distributed and comparable to results reported by other groups using advanced automated equipment. The coefficients of variation were smaller when the composed metabolite ratios (i.e. the ratios of a given resonance signal to the sum of all signals considered) were calculated. The composed metabolite ratios approach may be more sensitive for discrimination between normal and pathologically changed brain.
Grieb
P
P
Medical Research Centre, Polish Academy of Sciences, Warszawa. pgrieb@cmdik.pan.pl
Pieniazek
P
P
Sokół
M
M
Walecki
J
J
D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons; D012016:Reference Values; D014018:Tissue Distribution
D011522:Protons