A step backward in advancing DNA replication: rescue of stalled replication forks by RecG.
In the October 5 issue of Cell, Singleton et al. report the crystal structure of RecG protein bound to an analog of a stalled DNA replication fork. This structure shows how RecG can recognize branched DNA structures and suggests a mechanism for fork reversal, an early event in recombination-dependent reinitiation of DNA replication.
Dillingham
M S
MS
Section of Microbiology, University of California at Davis, Davis, CA 95616, USA.
Kowalczykowski
S C
SC
D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D004265:DNA Helicases / Q000737:chemistry / Q000378:metabolism*; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics; D029968:Escherichia coli Proteins; D008954:Models, Biological; D009690:Nucleic Acid Conformation
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C071446:RecG protein, E coli; D004265:DNA Helicases