title: Mechanical properties of myxomatous mitral valves.
abstract: OBJECTIVE
  We sought to characterize the mechanical properties of normal and myxomatous mitral valve tissues.
  
  
  METHODS
  We tested 113 mitral valve sections from patients undergoing mitral valve repair or replacement for myxomatous mitral valve prolapse and sections from 33 normal valves obtained at autopsy.
  
  
  RESULTS
  Myxomatous mitral valve leaflets were more extensible than normal leaflets when tested parallel to the free edge (41.2% +/- 18.5% vs 17.3% +/- 6.7% circumferential strain [mean +/- SD]; P <.001), as well as perpendicular to the free edge (43.2% +/- 19.4% vs 17.3% +/- 6.7% radial strain; P <.001). Myxoid leaflets were less stiff circumferentially (4.0 +/- 1.6 vs 6.1 +/- 1.4 kN/m; P <.001) and radially (4.5 +/- 1.1 vs 6.1 +/- 1.4 kN/m; P <.001) than normal leaflets. Leaflet strength, however, was similar in both groups.
  
  
  CONCLUSIONS
  Myxomatous mitral valve leaflets are physically and mechanically different from normal mitral valve leaflets. They are more extensible and less stiff. Compared with chordae examined previously, however, they are affected much less. Myxomatous mitral valve disease may therefore affect the collagen in the chordae more severely than that in the leaflets.
authors.affiliation: Department of Biomedical Engineering, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Barber
authors.forename: F K
authors.initials: FK
authors.lastname: Kasper
authors.forename: N B
authors.initials: NB
authors.lastname: Ratliff
authors.forename: D M
authors.initials: DM
authors.lastname: Cosgrove
authors.forename: B P
authors.initials: BP
authors.lastname: Griffin
authors.forename: I
authors.initials: I
authors.lastname: Vesely
mesh_terms: D016022:Case-Control Studies; D002815:Chordae Tendineae / Q000503:physiopathology; D004548:Elasticity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology; D008945:Mitral Valve Prolapse / Q000503:physiopathology*; D013314:Stress, Mechanical; D013718:Tensile Strength