title: Synthesis and microbiological activity of some 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives.
abstract: The synthesis and physicochemical properties of 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives are described. These new compounds were synthesised by alkylation in 4-N position and acylation and/or alkylation of 6-NH2 by phase transfer catalysis. Acid hydrolysis of 6-alkylacylamino group yielded 6-alkylamino-4-butyl-2H-benzo[1,4]thiazin-3-ones. The antimicrobial in vitro activity was determined on five compounds.
authors.affiliation: Escola de Farmácia, Universidade Federal de Ouro Preto, MG, Brazil. vera@cpd.ufop.br
authors.forename: V L
authors.initials: VL
authors.lastname: Guarda
authors.forename: M
authors.initials: M
authors.lastname: Perrissin
authors.forename: F
authors.initials: F
authors.lastname: Thomasson
authors.forename: E A
authors.initials: EA
authors.lastname: Ximenes
authors.forename: S L
authors.initials: SL
authors.lastname: Galdino
authors.forename: I R
authors.initials: IR
authors.lastname: Pitta
authors.forename: C
authors.initials: C
authors.lastname: Luu-Duc
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D013843:Thiazines