[Results of creating domestic medicinal forms of antineoplastic agents at the N. N. Blokhin Cancer Research Center of the Russian Academy of Medical Sciences].
Since there is a rise in morbidity and mortality rates due to malignant neoplasms, their drug therapy along with radiation and surgical methods remains a burning problem of modern medicine. Empirical and rational approaches to searching for new drugs have given rise to cancer agents that are widely used in clinical practice today. By taking into account the chemical and biological features of experimentally chosen active cytostatics, emphasis should be laid on the particular importance of development of effective dosage forms of antitumor substances by conducting chemical analytical, pharmacological engineering, biopharmaceutical, and pharmacokinetic studies. The purpose of the present paper is to assess the retrospective and present status of studies to design dosage forms of cancer drugs in our and foreign countries, and to pool the results of the author's own studies in designing dosage forms of antitumor substances from classes of chloroethylamines, nitrosoalkyl ureas, complex metal compounds, anthracene diones, antibiotics of plant origin, etc.
Oborotova
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D000047:Academies and Institutes / Q000458:organization & administration*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004304:Dosage Forms; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D004304:Dosage Forms