Portal biliopathy.
In patients with portal hypertension, particularly with extrahepatic portal vein obstruction, portal biliopathy producing biliary ductal and gallbladder wall abnormalities are common. Portal cavernoma formation, choledochal varices and ischemic injury of the bile duct have been implicated as causes of these morphological alterations. While a majority of the patients are asymptomatic, some present with a raised alkaline phosphatase level, abdominal pain, fever and cholangitis. Choledocholithiasis may develop as a complication and manifest as obstructive jaundice with or without cholangitis. Endoscopic sphincterotomy and stone extraction can effectively treat cholangitis when jaundice is associated with common bile duct stone(s). Definitive decompressive shunt surgery is sometimes required when biliary obstruction is recurrent and progressive.
Chandra
R
R
Department of Gastroenterology and Surgical Gastroenterology, Govind Ballabh Pant Hospital, New Delhi, India.
Kapoor
D
D
Tharakan
A
A
Chaudhary
A
A
Sarin
S K
SK
D000465:Algorithms; D001649:Bile Duct Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D002404:Catheterization; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002761:Cholangitis / Q000209:etiology; D005705:Gallbladder Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D011170:Portasystemic Shunt, Surgical; D016717:Sphincterotomy, Endoscopic; D015607:Stents