title: Comparative in vitro activities of five quinolone antibiotics, including gemifloxacin, against clinical isolates.
abstract: The in vitro activities of ciprofloxacin, ofloxacin, norfloxacin, levofloxacin and gemifloxacin against 343 clinical isolates were compared. Gemifloxacin showed the greatest activity, with MIC90 values as low as 0.03-0.25 mg/L against Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, methicillin-susceptible Staphylococcus aureus and Klebsiella pneumoniae, while methicillin-resistant Staphylococcus aureus, Enterococcus spp., Pseudomonas spp., Acinetobacter spp., Escherichia coli and Enterobacter spp. strains exhibited low rates of susceptibility to all five fluoroquinolones.
authors.affiliation: Institute for Experimental Medical Research, University of Istanbul, Istanbul, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Gönüllü
authors.forename: Z
authors.initials: Z
authors.lastname: Aktaş
authors.forename: M
authors.initials: M
authors.lastname: Salcioglu
authors.forename: C
authors.initials: C
authors.lastname: Bal
authors.forename: O
authors.initials: O
authors.lastname: Ang
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D000077735:Gemifloxacin; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D000077735:Gemifloxacin