title: Role of endothelin-1 in lung disease.
abstract: Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.
authors.affiliation: Cardiovascular Pulmonary Research Laboratory, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. karen.fagan@uchsc.edu
authors.forename: K A
authors.initials: KA
authors.lastname: Fagan
authors.forename: I F
authors.initials: IF
authors.lastname: McMurtry
authors.forename: D M
authors.initials: DM
authors.lastname: Rodman
mesh_terms: D000595:Amino Acid Sequence; D019332:Endothelin-1 / Q000737:chemistry / Q000502:physiology*; D006084:Graft Rejection; D006801:Humans; D008168:Lung / Q000098:blood supply; D008171:Lung Diseases / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000503:physiopathology; D016040:Lung Transplantation; D008969:Molecular Sequence Data; D012128:Respiratory Distress Syndrome / Q000503:physiopathology; D012140:Respiratory Tract Diseases / Q000503:physiopathology; D014652:Vascular Diseases / Q000503:physiopathology
chemical_list: D019332:Endothelin-1