Urinary steroid profile analysis.
BACKGROUND
A detailed analysis (profile) of the steroid metabolites in urine is useful for diagnosis of adrenal problems. Hospitals from many of UK health regions and around the world use the specialist assay and advisory service at UCLH. According to the total workload, samples are from patients with precocious puberty/premature adrenarche (21%), ambiguous genitalia (17%), Cushing's syndrome (13%), tumors (11%), polycystic ovaries (9%), hypertension (6%), problems of growth and development (5%), salt-loss (3%) and male pseudohermaphroditism (3%). Sixty percent of samples are from children and comprehensive reference data for steroid excretion rates in childhood unique to this laboratory were essential for interpretation of the results.


CONCLUSIONS
The recognition and high excretion rates of certain steroids not easily measured in blood or urine by any other assays was particularly in cases of hypertension and tumors. The assay is cost effective by comparison with the combined costs of several individual hormone measurements but that cost may delay early referral to a specialist centre and that is not in the best interests of the families involved.
Honour
J W
JW
SAS Laboratory, Department of Chemical Pathology, University College London Hospitals, Windeyer Building, Cleveland Street, WIT 4JF, England, London, UK. john.honour@uclh.org
D000307:Adrenal Gland Diseases / Q000175:diagnosis* / Q000652:urine; D002648:Child; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D013256:Steroids / Q000652:urine*
D013256:Steroids