Risk factors for coronary heart disease in type 1 diabetic children: the influence of apoE phenotype and glycemic regulation.
The effects of apolipoprotein E (apoE) phenotype and glycemic regulation on plasma levels of lipids and lipoproteins, low density lipoprotein (LDL) composition, LDL particle size, and LDL oxidation were examined in 35 type 1 diabetic children aged 5-12 years. All subjects were classified according to glycemic regulation (HbA(1c)<8% vs. HbA(1c)>8%). ApoE phenotypes were identified by isoelectric focusing (IEF) followed by immunoblotting. Results from two-way analysis of variance (ANOVA) showed that subjects with apoE 4/3 and HbA(1c)>8% had higher concentrations of total cholesterol (TC), LDL-cholesterol (LDL-C), and LDL-cholesterol ester (LDL-CE) than subjects with the same apoE phenotype and HbA(1c)<8%. LDL particles in all subjects were classified as the subclass pattern A. Both LDL particle size and susceptibility of LDL to oxidation were not different among subjects stratified by apoE phenotype. In conclusion, children with type 1 diabetes mellitus included in this study did not have high-risk lipoprotein profiles at this early stage of life. However, there was some indication that those with the apoE 4/3 phenotype were more likely to have more favorable lipid profiles when HbA(1c) levels were <8%.
Tso
T K
TK
Department of Food and Nutrition, Shih Chien University, Taipei 104, Taiwan, ROC.
Snook
J T
JT
Lozano
R A
RA
Zipf
W B
WB
D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007525:Isoelectric Focusing; D016018:Least-Squares Analysis; D008297:Male; D010641:Phenotype; D012307:Risk Factors
D001057:Apolipoproteins E; D001786:Blood Glucose; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin