Selenazolidines as novel organoselenium delivery agents.
Two new classes of selenazolidine-4(R)-carboxylic acids (2-oxo and 2-methyl-SCAs) were synthesized and characterized. Both were designed as latent forms of selenocysteine, intended to provide a chemically superior delivery form for selenium. The prodrugs may be clinically useful when selenium supplementation at supranutritional levels is indicated, such as in cancer chemoprevention.
Xie
Y
Y
Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
Short
M D
MD
Cassidy
P B
PB
Roberts
J C
JC
D016566:Organoselenium Compounds / Q000737:chemistry* / Q000378:metabolism; D011355:Prodrugs / Q000138:chemical synthesis*; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism; D012643:Selenium / Q000737:chemistry*; D017279:Selenocysteine / Q000737:chemistry* / Q000378:metabolism
D016566:Organoselenium Compounds; D011355:Prodrugs; D017279:Selenocysteine; C014811:selenaproline; D011392:Proline; D012643:Selenium