title: Impairment of human sperm motility and viability by quercetin is independent of lipid peroxidation.
abstract: Human sperm motility, viability and lipid peroxidation were assessed in Ringer-Tyrode supplemented with different concentrations of quercetin. An irreversible and dose-dependent fall in sperm motility was observed with quercetin (5-200 microm). However, sperm viability was decreased only at higher concentrations (50-100 microm) of quercetin. This inhibition in sperm motility and viability has been linked with decreased Ca2+-ATPase activity, as there was no effect of quercetin on sperm lipid peroxidation.
authors.affiliation: Department of Biophysics, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India. medinst@pgi.chd.nic.in
authors.forename: K L
authors.initials: KL
authors.lastname: Khanduja
authors.forename: A
authors.initials: A
authors.lastname: Verma
authors.forename: A
authors.initials: A
authors.lastname: Bhardwaj
mesh_terms: D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011794:Quercetin / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology
chemical_list: D011794:Quercetin; D000252:Calcium-Transporting ATPases