Circular dichroism spectra of the achiral guest N-aryl-N-nitrosamines included in the crystal host matrices of cholic acid.
The crystalline inclusion complexes of cholic acid with three symmetric N-aryl-N-nitrosamines were prepared, and their X-ray structures were solved. As a result of chiral conformations adopted by the enclathrated guest nitrosamines, the solid-state CD spectra were measured in KBr disks. The observed Cotton effect sign, corresponding to the n-pi* transition, was correlated with the helicity of the twisted nitrosamine chromophore conjugated with the N-aryl substituent. In addition, the absolute configuration of the enantiomorphous crystals of N-benzyl-N-nitroso-4-chloroaniline was established on the basis of the solid-state CD and X-ray crystallographic results.
Szyrszyng
M
M
Department of Chemistry, Technical University, 80-952 Gdansk, Poland.
Nowak
E
E
Gdaniec
M
M
Milewska
M J
MJ
Herman
A
A
Połoński
T
T
D002273:Carcinogens / Q000737:chemistry; D019826:Cholic Acid / Q000737:chemistry*; D002942:Circular Dichroism; D003460:Crystallization; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D009602:Nitrosamines / Q000737:chemistry*; D013237:Stereoisomerism
D002273:Carcinogens; D009602:Nitrosamines; D019826:Cholic Acid