Cell apoptosis induced by carcinogenic metals.
Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.
Chen
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F
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Vallyathan
V
V
Castranova
V
V
Shi
X
X
D000818:Animals; D017209:Apoptosis; D002273:Carcinogens / Q000633:toxicity*; D004249:DNA Damage; D006801:Humans; D008670:Metals / Q000633:toxicity*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
D002273:Carcinogens; D008670:Metals; D017382:Reactive Oxygen Species