Synthesis of macrotetrolide alpha, a designed polynactin analog composed of (+)- and (-)-bishomononactic acids.
Macrotetrolide alpha, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resolution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide alpha took seven steps without any loss of the intermediates.
Hanadate
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T
Division of Life Science, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Kiyota
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H
Oritani
T
T
D001671:Biochemistry / Q000379:methods*; D002352:Carrier Proteins / Q000737:chemistry*; D005663:Furans / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D011422:Propionates / Q000737:chemistry
D002352:Carrier Proteins; D005663:Furans; D007783:Lactones; D011422:Propionates; C453477:bishomononactic acid; C033135:gelatin binding protein; C453476:macrotetrolide alpha