Efficacy and safety of butenafine in superficial dermatophytoses (tinea pedis, tinea cruris, tinea corporis).
Superficial dermatophytoses of skin are very common infections seen in clinical practice. Besides topical imidazoles, triazoles and allylamines, topical butenafine (a benzylamine derivative) is a novel agent with broad antifungal activity. One hundred and eleven patients with tinea infections were enrolled in this multicentric, randomised, single-blind non-comparative study, which involved application of butenafine (1%) cream in tinea pedis (4 weeks) and tinea cruris and tinea corporis (2 weeks) cases. The results showed that butenafine causes rapid resolution of signs and symptoms (erythema itching, burning, crusting, scaling, etc), with good patient and physician acceptability of treatment. The broader spectrum fungicidal activity and better drug retention in superficial skin layers may be responsible for this beneficial effect.
Saple
D G
DG
Grant Medical College and GT Hospital, Mumbai.
Amar
A K
AK
Ravichandran
G
G
Korde
K M
KM
Desai
A
A
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D001596:Benzylamines / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use*; D016037:Single-Blind Method; D014005:Tinea / Q000188:drug therapy*
D000935:Antifungal Agents; D001596:Benzylamines; D009281:Naphthalenes; C067594:butenafine