title: Formulation and pharmacokinetic studies of acyclovir controlled-release capsules.
abstract: Acyclovir controlled-release capsules (CRCs) were prepared by a three-step process: (1) melt granulation of acclovir; (2) coating of granules with ethyl-cellulose, (3) incorporation of coated granules into hard gelatin capsules. In vitro release experiments showed that the main factors affecting the release rate were the mean particle size of the actylovir raw material and the amount of coating material applied. Release of acyclovir from the capsules was in accordance with the Higuchi equation. Pharmacokinetic studies in dogs after oral administration of acyclovir controlled-release capsules showed that the formulation was successful in providing slow release of aciclovir and was superior to a commercially available controlled-release formulation.
authors.affiliation: Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Peoples Republic of China. jstuftek@public1.ptt.js.cn
authors.forename: J
authors.initials: J
authors.lastname: Tu
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: Fei
authors.forename: X
authors.initials: X
authors.lastname: Li
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004285:Dogs; D004339:Drug Compounding; D005079:Excipients; D010316:Particle Size; D011092:Polyethylene Glycols; D011208:Powders; D012995:Solubility
chemical_list: D000998:Antiviral Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D005079:Excipients; D011208:Powders; D011092:Polyethylene Glycols; C013517:ethyl cellulose; D002482:Cellulose; D000212:Acyclovir