title: NSAID intolerance in chronic idiopathic urticaria: A study of its relationship with histamine-releasing activity of patients' sera.
abstract: BACKGROUND
  about one fourth of patients with chronic idiopathic urticaria (CIU) experience flares of hives after taking chemically unrelated nonsteroidal anti-inflammatory drugs (NSAID). The reasons for such intolerance are still elusive.
  
  
  OBJECTIVE
  this study aimed to investigate NSAID intolerance in patients with CIU in view of the in vivo and in vitro histamine releasing activity of their sera.
  
  
  METHODS
  117 adults (M/F 41/76) with CIU underwent intradermal test with autologous serum, and the ability of their sera to induce histamine release from normal blood donors was evaluated. NSAID intolerance was ascertained by careful interview.
  
  
  RESULTS
  overall, 32/117 (27 %) patients reported NSAID intolerance. The prevalence on NSAID intolerance did not differ in the three subgroups: negative on both in vivo and in vitro tests (9/36; 25 %), positive or intradermal test but negative on basophil histamine release assay (16/58; 28 %), or positive on both in vivo and in vitro tests (7/23; 30 %).
  
  
  CONCLUSIONS
  in patients with CIU intolerance to NSAID does not depend on the mechanism of histamine release.
authors.affiliation: Allergy Unit, Ospedale Caduti Bollatesi, Bollate, Italy. r.asero@libero.it
authors.forename: R
authors.initials: R
authors.lastname: Asero
authors.forename: M
authors.initials: M
authors.lastname: Lorini
authors.forename: C
authors.initials: C
authors.lastname: Suli
authors.forename: A
authors.initials: A
authors.lastname: Tedeschi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001491:Basophils / Q000378:metabolism; D001769:Blood / Q000276:immunology; D002908:Chronic Disease; D003429:Cross Reactions; D003875:Drug Eruptions / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006636:Histamine Release; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D015995:Prevalence; D014581:Urticaria / Q000097:blood / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal