A tandem Michael addition ring-closure route to the metabotropic receptor ligand alpha-(hydroxymethyl)glutamic acid and its gamma-alkylated derivatives.
Zhang
J
J
Georgetown University Medical Center, Drug Discovery Program, 3970 Reservoir Road NW, Washington, DC 20007-2197, USA.
Flippen-Anderson
J L
JL
Kozikowski
A P
AP
D003460:Crystallization; D003500:Cyclization; D005971:Glutamates / Q000138:chemical synthesis*; D008024:Ligands; D015394:Molecular Structure; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists* / Q000037:antagonists & inhibitors
C449086:(hydroxymethyl)glutamic acid; D005971:Glutamates; D008024:Ligands; D018094:Receptors, Metabotropic Glutamate; C025648:2-methylglutamic acid; C011859:hydroxyglutamic acid