Polyacetylene carboxylic acids from Mitrephora celebica.
A new polyacetylene carboxylic acid, 13(E),17-octadecadiene-9,11-diynoic acid (13,14-dihydrooropheic acid, 1), and the known 17-octadecene-9,11,13-triynoic acid (oropheic acid, 2) were isolated from the stem bark of Mitrephora celebica through bioassay-guided fractionation. Both compounds demonstrated significant activity against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis.
Zgoda
J R
JR
Graduate Program in Pharmacognosy, Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104-4495, USA.
Freyer
A J
AJ
Killmer
L B
LB
Porter
J R
JR
D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000480:Alkynes; D029061:Annonaceae / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053280:Diynes; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D008712:Methicillin / Q000494:pharmacology; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053279:Polyynes; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects
C440687:13,14-dihydrooropheic acid; C440688:17-octadecene-9,11,13-triynoic acid; D000480:Alkynes; D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D053280:Diynes; D011108:Polymers; D053279:Polyynes; D000114:Acetylene; D008712:Methicillin