Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4.
By screening nucleotide databases, sequences containing the complete genes of the human cationic amino acid transporters (hCATs) 1, 2 and 4 were identified. Analysis of the genomic organization revealed that hCAT-2 consists of 12 translated exons and most likely of 2 untranslated exons. The splice variants hCAT-2A and hCAT-2B use exon 7 and 6, respectively. The hCAT-2 gene structure is closely related to the structure of hCAT-1, suggesting that they belong to a common gene family. hCAT-4 consists of only 4 translated exons and 3 short introns. Exons of identical size and highly homologous to exon 3 of hCAT-4 are present in hCAT-1 and hCAT-2.
Hammermann
R
R
Institute of Pharmacology and Toxicology, Rheinische Friedrich-Wilhelms-Universität, Bonn, Federal Republic of Germany. r.hammermann@uni-bonn.de
Brunn
G
G
Racké
K
K
D027182:Amino Acid Transport System y+ / Q000737:chemistry / Q000235:genetics*; D026923:Amino Acid Transport Systems, Basic; D027201:Cationic Amino Acid Transporter 1 / Q000737:chemistry / Q000235:genetics*; D027202:Cationic Amino Acid Transporter 2 / Q000737:chemistry / Q000235:genetics*; D030561:Databases, Nucleic Acid; D005091:Exons; D005796:Genes; D006801:Humans; D007438:Introns
D027182:Amino Acid Transport System y+; D026923:Amino Acid Transport Systems, Basic; D027201:Cationic Amino Acid Transporter 1; D027202:Cationic Amino Acid Transporter 2; C420825:SLC7A1 protein, human; C414177:SLC7A2 protein, human; C420862:SLC7A4 protein, human