Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats.
Tizanidine was given systemically to rats with experimental postoperative pain. Partial pain relief was obtained, but the effect was not clinically significant. Although systemic tizanidine is effective in relieving experimental neuropathic pain, it is not as effective for postoperative pain.
Hord
A H
AH
Division of Pain Medicine, Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Denson
D D
DD
Azevedo
M I
MI
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D051381:Rats
D000316:Adrenergic alpha-Agonists; D000700:Analgesics; C023754:tizanidine; D003000:Clonidine