Enantioselective Synthesis of (+)-Isobretonin A.
An enantioselective synthesis of (+)-isobretonin A is described. The chiral glycerol moiety was enantioselectively prepared by reduction of an optically active beta-keto sulfoxide. The all-trans trienic part of the molecule was stereoselectively synthesized via reductive elimination of a 1,6-dibenzoate 2,4-diene with sodium amalgam.
Solladié
Guy
G
Laboratoire de Stéréochimie associé au CNRS, Ecole Européenne de Chimie, Polymères et Matériaux (ECPM), Université Louis Pasteur, 1 rue Blaise Pascal, 67008 Strasbourg, France.
Adamy
Marc
M
Colobert
Françoise
F