Synthesis and antimicrobial evaluation of chalcone and syndrome derivatives of 4(3H)-quinazolinone.
The increasing clinical importance of drug-resistant bacterial pathogens has encouraged additional microbiological and antibacterial research. New chalcone and sydnone derivatives of 4(3H)-quinazolinone were synthesized and evaluated for their antibacterial and antifungal activity. The microorganisms used were Escherichia coli ATCC 25922 as Gram-negative bacteria, Staphylococcus aureus ATCC 19433 as Gram-Positive bacteria and Candida albicans as yeast like fungi. The most potent compound was the nitroso derivative 6b, which exhibits interesting antibacterial and antifungal activities.
Bekhit
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AA
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
Habib
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NS
el-Din
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A
Bekhit
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A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002599:Chalcone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013558:Sydnones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D011799:Quinazolines; D013558:Sydnones; D002599:Chalcone