title: Titanocene-Catalyzed Reduction of Lactones to Lactols.
abstract: A convenient method for the conversion of lactones to lactols is described. The hydrosilylation to lactols is carried out via air-stable titanocene difluoride or a titanocene diphenoxide precatalyst using inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric reductant. These procedures have been demonstrated with a variety of substrates and proceed in good to excellent yield.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors.forename: Xavier
authors.initials: X
authors.lastname: Verdaguer
authors.forename: Marcus C.
authors.initials: MC
authors.lastname: Hansen
authors.forename: Scott C.
authors.initials: SC
authors.lastname: Berk
authors.forename: Stephen L.
authors.initials: SL
authors.lastname: Buchwald