title: Thermodynamic considerations of the interaction between caffeine and paracetamol in aqueous solutions.
abstract: Caffeine interacts physically with paracetamol thus producing changes in some physicochemical properties of paracetamol. There is evidence that the interaction may be in the form of a 1:1 association complex. Complexation of caffeine and paracetamol leads to increases in the aqueous solubility of the later. Thermodynamic influences play significant roles in the stabilization of the formed complex.
authors.affiliation: Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria.
authors.forename: V C
authors.initials: VC
authors.lastname: Okore
authors.forename: A C
authors.initials: AC
authors.lastname: Osuji
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D000465:Algorithms; D002110:Caffeine / Q000737:chemistry*; D004355:Drug Stability; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D012995:Solubility; D013816:Thermodynamics
chemical_list: D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D000082:Acetaminophen; D002110:Caffeine