title: Age-related decrease in paired-pulse intracortical inhibition in the human primary motor cortex.
abstract: Using biphasic magnetic stimuli, paired-pulse transcranial magnetic stimulation (TMS) at short interstimulus intervals (ISIs) was employed to investigate age-related changes in the balance between intracortical inhibition and facilitation. In 26 right-handed healthy individuals, motor evoked potentials were recorded from the relaxed right first dorsal interosseus muscle after paired-pulse TMS of the left primary motor hand area. The magnitude of intracortical paired-pulse inhibition at ISIs of 1-5 ms was markedly reduced in elderly individuals, whereas no age effect was observed for intracortical paired-pulse facilitation at ISIs of 11-15 ms. This finding demonstrates that normal aging is associated with a relative decrease in the excitability of intracortical inhibitory circuits. In conclusion, paired-pulse TMS provides a non-invasive means of studying age-related functional changes in the motor cortex.
authors.affiliation: Department of Neurology, Technische Universität München, Möhlstrasse 28, D-81675 Munich, Germany. alexander.peinemann@neuro.med.tu-muenchen.de
authors.forename: A
authors.initials: A
authors.lastname: Peinemann
authors.forename: C
authors.initials: C
authors.lastname: Lehner
authors.forename: B
authors.initials: B
authors.lastname: Conrad
authors.forename: H R
authors.initials: HR
authors.lastname: Siebner
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*