Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction.
The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) belong to the same subfamily of receptor tyrosine kinases with two extracellular alpha-subunits and two transmembrane beta-subunits. They share a high similarity of structure and intracellular signalling events. However, the IR and the IGF-IR mediate different effects on metabolism, cell proliferation, apoptosis and differentiation. Although some of the variation can be attributed to a different tissue distribution or subcellular localization, it can also be explained by structural differences in the beta-subunit, which may result in activation of specific substrates and signal pathways.
Dupont
J
J
Clinical Endocrinology Branch, NIDDK, Bethesda, Md 20892-1758, USA.
LeRoith
D
D
D000818:Animals; D017526:Receptor, IGF Type 1 / Q000502:physiology*; D011972:Receptor, Insulin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship
D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin