Local gene delivery to the vessel wall.
This review will provide an overview of delivery strategies that are being evaluated for vascular gene therapy. We will limit our discussion to those studies that have been demonstrated, utilizing in vivo model systems, to limit post-interventional restenosis. We also discuss the efficacy of the vectors and methods currently being used to transfer genetic material to the vessel wall. The efficiency of these techniques is a critical issue for the successful application of gene therapy.
Smith
R C
RC
Division of Cardiovascular Research, St Elizabeth's Medical Center, Boston, MA 02135, USA.
Walsh
K
K
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D003324:Coronary Artery Disease / Q000628:therapy*; D003331:Coronary Vessels; D015316:Genetic Therapy / Q000379:methods*