New metal complexes of 4-methyl-7-hydroxycoumarin sodium salt and their pharmacological activity.
Complexes of copper (II), zinc (II), nickel (II), cobalt (II) and iron (III) with 4-methyl-7-hydroxycoumarin sodium salt (Mendiaxon, Hymecromone) were synthesized by mixing of equimolar amounts of the respective metal nitrates and 4-methyl-7-hydroxycoumarin sodium salt in water. The complexes were characterized and identified by elemental analysis, conductivities, IR, 1H NMR spectroscopy and mass spectral data. DTA and TGA have been applied to study the compositions of the compounds. Thermal analysis of the complexes indicate the formation of compounds which correspond to the compositions Met(HL)2 x nH2O, where Met = Cu, Zn, Ni, Co; n = 2, 3 or 4 and Fe(HL)3 x 5H2O. The newly synthesized compounds were assayed for acute intraperitoneal and per oral toxicity, influence on blood clotting time and the most active complex was investigated for spasmolytic activity.
Kostova
I P
IP
Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria.
Manolov
I I
II
Nicolova
I N
IN
Danchev
N D
ND
D000284:Administration, Oral; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006923:Hymecromone / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D008670:Metals / Q000032:analysis*; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
D003374:Coumarins; D008670:Metals; D010276:Parasympatholytics; D006923:Hymecromone