[The effect of unfractionated heparin and low molecular weight heparins on chemotaxis of peripheral blood neutrophils].
Heparin and its derivatives exhibit a wide spectrum of biological functions affecting adhesion, activation and trafficking of leukocytes. The aim of that study was to investigate whether heparins are chemoattractants for neutrophils from peripheral blood of healthy volunteers and if chemotactic effects are identical in the same concentrations of unfractionated heparin and 3 low molecular weight heparin-nadroparin, enoxaparin and reviparin. We found that heparins are chemoatractants for neutrophils with potency comparable to fMLP known chemoatractant. Chemotaxis elucidated by identical doses by unfractionated heparin differed significantly from that after reviparin and enoxaparin.
Krasnowska
M
M
Katedra i Klinika Chorób Wewnetrznych i Alergologii AM we Wrocławiu.
Zak-Nejmark
T
T
Krasnowski
R
R
D000328:Adult; D002633:Chemotaxis / Q000187:drug effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006493:Heparin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000187:drug effects*
D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D006493:Heparin