Thyroid hormone deficiency determines predisposition to catalepsy in rats.
The role of thyroid hormones in predisposition to cataleptic reaction was investigated. GC rats with genetic predisposition to catalepsy were characterized by decreased serum thyroxin content in comparison with Wistar rats. Thyroidectomy even more reduced the blood concentration of thyroxin in GC rats 30 days postoperation and augmented predisposition to catalepsy in both rat strains.
Barykina
N N
NN
Laboratory of Evolutional Genetics, Laboratory of Phenogenetics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk.
Chugui
V F
VF
Alekhina
T A
TA
Kolpakov
V G
VG
Ivanova
E A
EA
Maksyutova
A V
AV
Kulikov
A V
AV
D000818:Animals; D002375:Catalepsy / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013963:Thyroid Hormones / Q000172:deficiency*; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood* / Q000172:deficiency
D013963:Thyroid Hormones; D013974:Thyroxine