Na+/Li+ exchange kinetic characterization. Red blood cells from normotensive individuals.
The plasma membrane Na+/Li+ exchange is of research interest because it is involved in some pathologic states. A kinetic analysis of this transport system would be of greater importance as compared to the flux determination under "standard" conditions (reactants saturating levels) as a way to define normal values. Unidirectional lithium fluxes in red blood cells from normal adults were determined as a function of "trans" (contralateral) sodium ion concentration. Relating Li+ efflux and influx (Na+ "trans") kinetic parameters we found free carrier reorientation between the two phases (asymmetry).
Corchs
J L
JL
Department of Physiology, School of Medicine, National University of Rosario, Santa Fe, Argentina. gmujica@citynet.net.ar
Taborda
D
D
Mujica
G
G
Serrani
R E
RE
D002414:Cations, Monovalent; D002478:Cells, Cultured; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport; D007700:Kinetics; D008094:Lithium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D013054:Spectrophotometry, Atomic
D002414:Cations, Monovalent; D008094:Lithium; D012964:Sodium; D011188:Potassium