title: Total Synthesis of the Nonadjacent Bis-Tetrahydrofuran Annonaceous Acetogenin Squamostatin-D.
abstract: A total synthesis of the Annonaceous acetogenin squamostatin-D is described. Key adjacent stereocenters were introduced through enantioselective addition of chiral oxygenated allylic tin and indium reagents to aldehyde subunits. The isolated stereocenter at C12 was constructed through addition of a functionalized organozinc reagent to an aldehyde subunit in the presence of a chiral bis-sulfonamide-titanium catalyst.
authors.affiliation: Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901.
authors.forename: James A.
authors.initials: JA
authors.lastname: Marshall
authors.forename: Hongjian
authors.initials: H
authors.lastname: Jiang