title: Role of pre-emptive analgesia in reduction mammaplasty.
abstract: Pre-emptive analgesia is an antinociceptive treatment that prevents altered central excitability from high intensity noxious stimuli. The aim of this study was to evaluate the efficacy of pre-emptive analgesia in patients due to have elective breast reduction that usually requires drugs for postoperative pain control. Sixty women, ASA grades I-II, were randomly divided into two groups: 30 patients were given ropivacaine infiltration 1.5 mg/ml plus adrenaline 1/200,000 in normal saline 100 ml before the skin incision, and 30 had normal saline 100 ml plus adrenaline 1/200,000 infiltrated. Postoperative pain was evaluated by an observer who was unaware of the treatment given, and scored on a visual analogue score (VAS) during the first 72 hours postoperatively. Analgesic requirements were recorded. There was a statistically significant difference between groups in the amount of additional pain control required during the early postoperative period, which suggests that pre-emptive analgesia reduces pain after reduction mammaplasty.
authors.affiliation: Department of Anesthesiology, University of Rome La Sapienza, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Di Marco
authors.forename: F R
authors.initials: FR
authors.lastname: Grippaudo
authors.forename: G
authors.initials: G
authors.lastname: Della Rocca
authors.forename: R
authors.initials: R
authors.lastname: De Vita
mesh_terms: D000328:Adult; D000577:Amides; D000698:Analgesia; D000779:Anesthetics, Local; D004837:Epinephrine; D005260:Female; D006801:Humans; D016462:Mammaplasty; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control*; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D004837:Epinephrine