Systemic aspects of allergic disease: the role of the bone marrow.
In recent years, there has been an increasing appreciation of the important contribution of bone-marrow-related, hemopoietic mechanisms to allergic diseases. Eosinophil/basophil-progenitor levels fluctuate in the peripheral blood during allergen exposure and the cells home to peripheral tissue, where they differentiate. It is becoming apparent that several cytokines, particularly IL-5, have multiple effects on progenitors and allergic inflammation. Within the past few years, studies of the therapeutic implications of this bone marrow contribution to atopy have been initiated; the effects of corticosteroids, leukotriene-receptor blockers, antagonism of IL-5 and modulation of differentiation by retinoic acid on progenitors will be reviewed.
Cyr
M M
MM
Department of Medicine, HSC-3V46, McMaster University, 1200 Main Street West, Ontario L8N 3Z5, Hamilton, Canada.
Denburg
J A
JA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D018952:Antigens, CD34 / Q000032:analysis; D001491:Basophils / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D005938:Glucocorticoids / Q000627:therapeutic use; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy; D015848:Interleukin-5 / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D051379:Mice; D018448:Models, Immunological; D013256:Steroids; D014212:Tretinoin / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D018952:Antigens, CD34; D005938:Glucocorticoids; D015848:Interleukin-5; D020024:Leukotriene Antagonists; D013256:Steroids; D014212:Tretinoin