Effects of mirtazapine on the levels of exogenous histamine in the plasma of the cat.
Effects of the antidepressant drug mirtazapine on plasma levels and on the kinetics of injected histamine were studied in the cat. In the dose of 0.6 mg/kg mirtazapine did not affect the characteristics of the elimination curve of histamine. The higher dose of mirtazapine (1.2 mg/kg) prevented the increase of plasma histamine levels.
Arko
M
M
Department of Pharmacology and Experimental Toxicology, Medical Faculty, Ljubljana, Slovenia.
Florjanc
T I
TI
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D002415:Cats; D005260:Female; D006632:Histamine / Q000097:blood / Q000493:pharmacokinetics*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008803:Mianserin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000078785:Mirtazapine
D000929:Antidepressive Agents, Tricyclic; D006634:Histamine H1 Antagonists; D008803:Mianserin; D006632:Histamine; D000078785:Mirtazapine