12/15-lipoxygenase, oxidative modification of LDL and atherogenesis.
Lipoxygenases comprise a family of non-heme iron-containing dioxygenases that stereospecifically insert molecular oxygen into free or esterified polyunsaturated fatty acids. The dual specificity 12/15-lipoxygenases have been implicated in the oxidative modification of low-density lipoproteins and foam cell formation primarily based on in vitro studies. Recent in vivo data obtained with 12/15-lipoxygenase-deficient mice crossbred to apolipoprotein E-deficient mice have established a proatherogenic role for this pathway. In contrast, previous experiments with macrophage expressing 15-lipoxygenase transgenic rabbits have suggested an anti-atherogenic role. Possible explanations are presented that may elucidate these differences.
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BRBII/III Rm. 814, Department of Pharmacology, Center for Experimental Therapeutics, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA 19104-6160, USA. colin@spirit.gcrc.upenn.edu
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D000818:Animals; D001092:Arachidonate 12-Lipoxygenase / Q000378:metabolism*; D001093:Arachidonate 15-Lipoxygenase / Q000378:metabolism*; D001161:Arteriosclerosis / Q000201:enzymology* / Q000473:pathology; D005544:Forecasting; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D051379:Mice; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011817:Rabbits; D012680:Sensitivity and Specificity
D008077:Lipoproteins, LDL; D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase