Increase in B19 viral load prior to relapse of anaemia in an AIDS patient with persistent B19 infection.
Anaemia caused by persistent parvovirus B19 infection can be remitted by intravenous immunoglobulin (IVIG) treatment. However, maintenance IVIG therapy is required in some AIDS patients as well as patients with combined immuno-deficiency because of relapse of anaemia. We used a simple semi-quantitative polymerase chain reaction (PCR) method to trace plasma B19 viral load after administration of IVIG. We noted that the rebound of B19 viral load occurred 6 weeks prior to detection of anaemia. This method may be helpful in determining the interval of maintenance IVIG therapy.
Hung
C C
CC
Department of Internal Medicine, Section of Infectious Disease, National Taiwan University Hospital, Taipei, Taiwan.
Lee
K L
KL
Chen
M Y
MY
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D000328:Adult; D000740:Anemia / Q000188:drug therapy / Q000821:virology*; D004279:DNA, Viral / Q000737:chemistry / Q000302:isolation & purification; D017809:Fatal Outcome; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D010322:Parvoviridae Infections / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D016732:Parvovirus B19, Human / Q000235:genetics / Q000254:growth & development* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D019562:Viral Load; D014766:Viremia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D004279:DNA, Viral; D016756:Immunoglobulins, Intravenous