Analysis of expression patterns: the scope of the problem, the problem of scope.
Studies of the expression patterns of many genes simultaneously lead to the observation that even in closely related pathologies, there are numerous genes that are differentially expressed in consistent patterns correlated to each sample type. The early uses of the enabling technology, microarrays, was focused on gathering mechanistic biological insights. The early findings now pose another clear challenge, finding ways to effectively use this kind of information to develop diagnostics.
Chen
Y
Y
Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Yakhini
Z
Z
Ben-Dor
A
A
Dougherty
E
E
Trent
J M
JM
Bittner
M
M
D016000:Cluster Analysis; D019937:Diagnostic Techniques and Procedures; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis