title: Surfactant treatment in premature infants with Respiratory Distress Syndrome in Curaçao.
abstract: Surfactant replacement therapy for Respiratory Distress Syndrome (RDS) in premature neonates has been established as an effective treatment, although significant mortality and morbidity remain. In Curaçao, surfactant became available as a therapeutic option in 1994. A retrospective cohort study was performed to describe the results of surfactant treatment in premature newborns with RDS in Curaçao between 1994 and 1998. Of 429 infants admitted to the study hospital in this period, 7.5% (n = 32) developed RDS and were treated with surfactant. Twenty-five per cent (n = 8) of these infants died, most of them in the first year of surfactant treatment. Twenty-eight per cent (n = 9) developed bronchopulmonary dysplasia (BPD), the most frequently observed complication. The highest incidence of BPD (44%) was found in the very low birth weight infants (750-1500 g); all infants with BPD were 27-30 weeks of gestational age. The duration of ventilator dependence was significantly associated with the development of BPD (p < 0.05). No other risk factors for complications during the treatment course could be identified. The mean time between birth and the first surfactant treatment was more than nine hours. In this study, we found low incidence rates of RDS and BPD, and a considerable mortality in surfactant treated newborns. This pilot study shows that surfactant treatment of premature infants is feasible in Curaçao. Earlier administration of surfactant, preferably within 2-3 hours after birth, is expected to lower the risk of death and oxygen dependence.
authors.affiliation: St Elisabeth Hospital, Departments of Paediatrics and Clinical Epidemiology and Biostatistics, Curaçao, Netherlands Antilles. e.verhagen@bkk.azg.nl
authors.forename: A A
authors.initials: AA
authors.lastname: Verhagen
authors.forename: S O
authors.initials: SO
authors.lastname: Keli
authors.forename: G N
authors.initials: GN
authors.lastname: van der Meulen
authors.forename: H
authors.initials: H
authors.lastname: Wiersma
authors.forename: M
authors.initials: M
authors.lastname: Arias
authors.forename: I R
authors.initials: IR
authors.lastname: Angelista
authors.forename: F D
authors.initials: FD
authors.lastname: Muskiet
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D009427:Netherlands Antilles / Q000453:epidemiology; D010865:Pilot Projects; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D011663:Pulmonary Surfactants