No effect of anti-oxidative therapy on cerebral amyloidosis following ischemia-reperfusion brain injury.
The distribution patterns of amyloid precursor protein (APP) fragments were studied immunocytochemically in the rat brain before, after 10 min ischemia and following treatment by idebenone. Six months after brain ischemia intense staining for APP appeared in extra- and intracellular space. These findings indicate that APP is involved in the degeneration process of brain neuronal and glial cells following ischemia-reperfusion injury and anti-oxidative therapy did not prevent and/or stop this phenomenon.
Pluta
R
R
Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warszawa. rp@ibbrain.ibb.waw.pl
D000544:Alzheimer Disease / Q000209:etiology*; D016564:Amyloid beta-Protein Precursor / Q000032:analysis / Q000378:metabolism*; D000686:Amyloidosis / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D016227:Benzoquinones / Q000627:therapeutic use*; D016923:Cell Death; D004353:Drug Evaluation, Preclinical; D005110:Extracellular Space / Q000737:chemistry; D005260:Female; D005609:Free Radicals; D006323:Heart Arrest / Q000150:complications; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D007424:Intracellular Fluid / Q000737:chemistry; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D012307:Risk Factors; D014451:Ubiquinone / Q000031:analogs & derivatives
D016564:Amyloid beta-Protein Precursor; D000975:Antioxidants; D016227:Benzoquinones; D005609:Free Radicals; D018696:Neuroprotective Agents; D014451:Ubiquinone; C036619:idebenone