title: Synthesis of 2'beta-Deoxy-[8-(13)C;amino,9-(15)N(2)]adenosine: Unusual Annulation Conditions To Assemble the Purine Core.
abstract: Synthesis of 2'beta-Deoxy-[8-(13)C;amino,9-(15)N(2)]adenosine has been accomplished using a five-step process which employs a novel annulation of [(13)C]formamide [N-(4-[(15)N]amino-6-chloro-5-pyrimidinyl)] 2. To effect this dehydration, a complex of triethyl phosphite and TiCl(2)(i-OPr)(2) was used. 6-Chloro-[8-(13)C; 9-(15)N]purine was then converted in two steps to 2'beta-deoxy-[8-(13)C;amino,9-(15)N(2)]adenosine.
authors.affiliation: Los Alamos National Laboratory, Chemical Sciences and Technology Division, CST-4, The Bioscience and Biotechnology Group, MS; E529, Los Alamos, New Mexico 87545.
authors.forename: Charles C.
authors.initials: CC
authors.lastname: Orji
authors.forename: Ryszard
authors.initials: R
authors.lastname: Michalczyk
authors.forename: Louis A. "Pete
authors.initials: LA
authors.lastname: Silks III