[Caustic sclerosing cholangitis following injection of anthelmintics into rat bile duct. An experimental study].
It is the purpose of the study to assay the effect of intrabiliary injection of scolicide agents most frequently used in clinical practice. Fifty-five albino rats are divided up into 4 groups according to type of solution injected, as follows: control group A--with physiological saline, B--20 per cent natrium chloratum, C--10 per cent povidone iodine, and D--3 per cent hydrogenium hyperoxidatum. Histological assessment of extrahepatic bile ducts and liver parenchyma are conducted at 10 and 90 days of treatment. Lesions along with cholestatic and reparative changes are documented, most markedly expressed after injecting 20 per cent NaCl, rather weakly--after 10 per cent povidone iodine, and least pronpunced after injecting 3 per cent hydrogen peroxide. Periductal sclerosis is noted in three rats only injected with hypertonic saline. The experimental results are analyzed, and clinically relevant inferences reached.
Tasev
V
V
Nikolaeva
E
E
Bulanov
D
D
Gaidarski
R
R
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000633:toxicity*; D017734:Bile Ducts, Extrahepatic / Q000187:drug effects* / Q000473:pathology; D002760:Cholangiopancreatography, Endoscopic Retrograde; D015209:Cholangitis, Sclerosing / Q000139:chemically induced* / Q000473:pathology; D004444:Echinococcosis, Hepatic / Q000188:drug therapy / Q000473:pathology; D006861:Hydrogen Peroxide / Q000008:administration & dosage / Q000627:therapeutic use; D015552:Injections, Intralesional; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012972:Sodium Hydroxide / Q000008:administration & dosage / Q000633:toxicity*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D000871:Anthelmintics; D012972:Sodium Hydroxide; D011206:Povidone-Iodine; D006861:Hydrogen Peroxide