Mother-to-child discordance in HLA-G exon 2 is associated with a reduced risk of perinatal HIV-1 transmission.
Definitive genetic parameters correlating with mother-to-child transmission (MCT) of HIV have not been fully established. We screened for the potential correlation between HLA-G variants and MCT, in a cohort of mother-child pairs. Discordance in exon 2 of HLA-G was significantly more common among non-transmitting (93%) than transmitting mother-child pairs (40%). Our results suggest that mother-child pairs both carrying the identical mutation in HLA-G exon 2 may be at higher risk of MCT of HIV-1.
Aikhionbare
F O
FO
Department of Microbiology, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Hodge
T
T
Kuhn
L
L
Bulterys
M
M
Abrams
E J
EJ
Bond
V C
VC
D004279:DNA, Viral / Q000097:blood; D005091:Exons / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D009154:Mutation; D011110:Polymorphism, Genetic / Q000235:genetics*
D004279:DNA, Viral; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I