[Verify the optimum administration of anticancer agent--cisplatin].
Cisplatin shows effectiveness for various solid cancers and often plays a role as the key drug in combination chemotherapy. The most common method of cisplatin administration is bolus intra-venous injection. However, other administration methods are tried in order to reinforce the effect, and also to reduce the side effects. Generally, renal damage is more prominent with bolus injection. In contrast, bone marrow suppression is more severe with intermittent administration. Although there is no clear evidence about the anti-tumor effects, a dramatic local effect is sometimes observed by intra-arterial chemotherapy. By intraperitoneal chemotherapy, while a systemic effect is observed in addition to local effects, due consideration of the systemic side effects is also needed. These protocols are used in many institutes, but the efficacy is not yet proven by comparison trials. In future, randomized prospective studies should be performed to test the usefulness of the regimens.
Miyanaga
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N
Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Akaza
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H
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010478:Chemotherapy, Cancer, Regional Perfusion; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004334:Drug Administration Schedule; D006801:Humans; D007262:Infusions, Intravenous; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D000970:Antineoplastic Agents; D002945:Cisplatin