Evidence of recurrent atypical meningioma with rhabdoid transformation and expression of pyrogenic cytokines in a child presenting with a marked acute-phase response: case report and review of the literature.
Children presenting with acute systemic illnesses that lack specific clinical or serological defining features may be diagnosed as having a chronic infection, an atypical systemic vasculitis or a connective tissue disease, but often turn out to have occult neoplasias. Cytokines have been implicated in causing many of the systemic effects in such cases. In this study, we describe the case of a 9-year-old boy presenting at an interval of 18 months with a marked acute-phase response due to a recurrent atypical meningioma with rhabdoid transformation of the tentorium cerebelli. Resection of the recurrent tumor was curative. We evaluated in detail the local and systemic production of cytokines released by the primary and the recurrent tumor. Blood and CSF samples were taken pre-, intra-, and postoperatively, and the production of IL-6, IL-1beta, and TNF-alpha was measured by enzyme-linked immunosorbent assays (ELISA). The level of IL-6 in CSF was about 150-fold increased before tumor resection, normalizing postoperatively. On the contrary, the levels of IL-1beta and TNF-alpha in CSF and of IL-6, IL-1beta, and TNF-alpha in serum were pre-, intra-, and postoperatively within normal limits. Cytokine production was also evaluated immunohistochemically, and confirmed strong IL-6 and TNF-alpha expression in the primary and the recurrent tumor, while expression of IL-1beta was lacking. The scattered MHC class II- and leukocyte common antigen (LCA)-expressing inflammatory cells, which were infiltrating exclusively the tumoral stroma, had no detectable cytokine immunoreactivity. We conclude that chronic IL-6 and TNF-alpha production by the tumor cells in this patient was responsible for the severe systemic illness with which he presented.
Rittierodt
M
M
Department of Neurosurgery, Hannover Medical School, Hanover, Germany.
Tschernig
T
T
Samii
M
M
Walter
G F
GF
Stan
A C
AC
D000208:Acute Disease; D002648:Child; D003388:Cranial Fossa, Posterior / Q000473:pathology; D016207:Cytokines / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D003893:Desmin / Q000378:metabolism; D004388:Dura Mater / Q000473:pathology* / Q000648:ultrastructure; D004797:Enzyme-Linked Immunosorbent Assay; D005335:Fever of Unknown Origin / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000473:pathology; D008579:Meningioma / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000473:pathology; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000473:pathology; D011749:Pyrogens / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D018335:Rhabdoid Tumor / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000473:pathology; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D016207:Cytokines; D003893:Desmin; D007375:Interleukin-1; D015850:Interleukin-6; D011749:Pyrogens; D014409:Tumor Necrosis Factor-alpha; D014746:Vimentin; D005346:Fibroblast Growth Factors