title: Normal values for sincalide cholescintigraphy: comparison of two methods.
abstract: OBJECTIVE
  To establish normal gallbladder ejection fraction (GBEF) values for two sincalide (cholecystokinin [CCK]) infusion dose rates, 0.01 microg per kilogram of body weight infused for 3 minutes and 0.01 microg/kg infused for 60 minutes.
  
  
  METHODS
  Twenty healthy subjects were examined. GBEFs were calculated for the 3-minute infusion and for each 15-minute interval for the 60-minute infusion. Normal values were determined by using the mean +/- 2 SDs and a more rigorous statistical analysis.
  
  
  RESULTS
  With the 3-minute infusion, GBEFs were significantly more variable than with the 45- and 60-minute values for the 60-minute infusion (P < .01, .002). With intervals including 95% of the population, the GBEF lower normal range was 16.8% for the 3-minute infusion but 31% and 41% for the 45- and 60-minute values, respectively. GBEFs of less than 35% were noted in six (30%) of 20 healthy subjects with the 3-minute infusion but in only one with the 60-minute infusion. Hepatobiliary ultrasonography was performed in six of seven subjects with GBEF of 36% or less, and US findings in all six were normal.
  
  
  CONCLUSIONS
  A 3-minute infusion of sincalide, 0.01 microg/kg, produces too variable a GBEF response to establish a clinically useful normal range. With 0.01 microg/kg infused for 60 minutes, clinically useful normal values were established at 45 and 60 minutes.
authors.affiliation: Division of Nuclear Medicine, Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007, USA. ziessmah@gunet.georgetown.edu
authors.forename: H A
authors.initials: HA
authors.lastname: Ziessman
authors.forename: L R
authors.initials: LR
authors.lastname: Muenz
authors.forename: A K
authors.initials: AK
authors.lastname: Agarwal
authors.forename: A A
authors.initials: AA
authors.lastname: ZaZa
mesh_terms: D000328:Adult; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012016:Reference Values; D012844:Sincalide / Q000008:administration & dosage
chemical_list: D012844:Sincalide