title: Risk of birth defects in a population exposed to environmental lead pollution.
abstract: To investigate the relation between environmental lead and risk of birth defects in humans, we examined the prevalence at birth of congenital anomalies in an industrial area of northern Italy heavily polluted with lead. Through a population-based registry of birth defects, we identified anomalies diagnosed during three consecutive periods characterized by decreasing environmental lead exposure, 1982-1986, 1987-1990 and 1991-1995. In the lead-polluted area, we observed an excess risk of cardiovascular defects which decreased from 2.59 [95% confidence interval (CI) 1.68-3.82] in the first period to 1.18 (95% CI 0.62-2.06) and 0.97 (95% CI 0.57-1.54) in the subsequent periods. We also found an excess risk of oral clefts and musculoskeletal anomalies, with decreasing trends over time. We could not identify homogeneous patterns of temporal variation for other congenital anomalies, neither did we detect cases of neural tube defects. These results appear to support an association between severe parental lead exposure and specific birth defects.
authors.affiliation: Dipartimento di Sienze Igienistiche, Microbiologiche e Biostatistics, Università di Modena e Reggio Emilia, Modena, Italy. vinceti@unimo.it
authors.forename: M
authors.initials: M
authors.lastname: Vinceti
authors.forename: S
authors.initials: S
authors.lastname: Rovesti
authors.forename: M
authors.initials: M
authors.lastname: Bergomi
authors.forename: E
authors.initials: E
authors.lastname: Calzolari
authors.forename: S
authors.initials: S
authors.lastname: Candela
authors.forename: A
authors.initials: A
authors.lastname: Campagna
authors.forename: M
authors.initials: M
authors.lastname: Milan
authors.forename: G
authors.initials: G
authors.lastname: Vivoli
mesh_terms: D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000209:etiology*; D004781:Environmental Exposure; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D007854:Lead / Q000009:adverse effects*; D008297:Male; D012189:Retrospective Studies; D018570:Risk Assessment
chemical_list: D007854:Lead