Neurochemical relationships in the action of opioid analgesics on cerebral cortex.
The experiments with unrestrained cats showed that opioid analgesics in near-analgesic doses decreased the amplitude of the primary test response recorded in the second sensorimotor zone of the cerebral cortex in 20-150-msec interval between the stimuli applied to thalamocortical fibers radiating from thalamic n. VPL. Application of test substances affecting certain neurotransmitter processes and microionophoretic application of drugs and neurotransmitters to cortical neurons showed that the inhibitory effect of opioid analgesics on cerebral cortex is probably realized through GABA-, serotonin-, beta-adreno-, and cholinergic structures. The excitatory amino acids are also involved into this process.
Fisenko
V P
VP
Department of Pharmacology, Therapeutics, and Medical Prophylactic Faculties, I. M. Sechenov Moscow Medical Academy.
D000344:Afferent Pathways / Q000378:metabolism; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D007478:Iontophoresis; D007980:Levodopa / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010146:Pain / Q000503:physiopathology; D013788:Thalamus / Q000166:cytology / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000701:Analgesics, Opioid; D007980:Levodopa; D005680:gamma-Aminobutyric Acid