Prevalence of breast cancer predisposition gene mutations in Chinese women and guidelines for genetic testing.
BACKGROUND
Breast cancer is the most common cancer among Caucasian females. On average, 1 in 12 women will have breast cancer during their lifetime. There is a marked difference in breast cancer incidence in Chinese. In Hong Kong women, the lifetime risk is 1 in 29. BRCA1 and BRCA2 are high-penetrant cancer predisposition genes, but the prevalence and nature of mutations in these genes appear to be ethnic-specific. It is not clear if the differences in cancer incidence between Caucasians and Chinese are due to genetic or environmental factors.


METHODS
In our investigation of BRCA1 mutations among Chinese female patients in Hong Kong, BRCA1 mutations were found in 3.8% (CI: 1.3-8.8%) of 130 breast cancer patients. The prevalence was higher in a separate group of 56 early onset patients, aged<45 years, (8%, CI: 2.2-19.2). Most of the mutations were different from those reported in Caucasians. A deletion 589delCT was found in three unrelated patients, which may represent a common mutation. Similar prevalence of mutations was reported in Taiwan and Singapore Chinese. Other low-penetrant cancer predisposition genes may be important in the pathogenesis of the majority of breast cancers.


CONCLUSIONS
Although the epidemiology of breast cancer is different between Caucasians and Chinese, the prevalence of mutations in the high-penetrant cancer-predisposition gene of BRCA1 is comparable. It may indicate that the role of genetic contribution to breast cancer may be similar in the two ethnic groups and the difference in epidemiology may be contributed more heavily by environmental factors.
Tang
N L
NL
Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, SAR, Hong Kong, China. nelsontang@cuhk.edu.hk
Choy
K W
KW
Pang
C P
CP
Yeo
W
W
Johnson
P J
PJ
D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000592:standards*; D006801:Humans; D015994:Incidence; D009154:Mutation; D017410:Practice Guidelines as Topic; D015995:Prevalence; D012307:Risk Factors
D024682:BRCA2 Protein