Natural killer gene complex (Nkc) allelic variability in inbred mice: evidence for Nkc haplotypes.
Allelic variability for mouse Chromosome 6 Nkc loci was assessed in 22 common laboratory strains of mice using selected natural killer gene complex (Nkc)-linked sequence tagged site markers. Most Nkc markers distinguished three or more alleles for a particular locus in the assessed mouse strains. Nkc locus alleles were highly conserved among genealogically related inbred strains, whereas far less similarity was observed among unrelated strains. Concurrent strain-to-strain comparisons for all Nkc-linked loci revealed common and uncommon Nkc haplotypes, including some that were likely recombinant. Nkc allele and haplotype assignments in inbred mouse strains and correlation with phenotypic traits should facilitate positional gene cloning strategies for unknown Nkc-linked trait modification loci.
Brown
M G
MG
Department of Internal Medicine, University of Virginia School of Medicine, Box 800412, Charlottesville, VA 22908, USA. mgb4n@virginia.edu
Scalzo
A A
AA
Stone
L R
LR
Clark
P Y
PY
Du
Y
Y
Palanca
B
B
Yokoyama
W M
WM
D000483:Alleles; D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics*; D000950:Antigens, Ly; D000954:Antigens, Surface / Q000235:genetics; D008040:Genetic Linkage; D006239:Haplotypes; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D055651:NK Cell Lectin-Like Receptor Subfamily B; D010641:Phenotype; D055630:Receptors, NK Cell Lectin-Like; D013045:Species Specificity
D000943:Antigens, Differentiation; D000950:Antigens, Ly; D000954:Antigens, Surface; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D055651:NK Cell Lectin-Like Receptor Subfamily B; D055630:Receptors, NK Cell Lectin-Like