Focal adhesion kinase modulates B cell receptor-transduced apoptosis in WEHI 231 cells.
B cell receptor (BCR) cross-linking induces tyrosine phosphorylation and activation of focal adhesion kinase (FAK), suggesting the role of this molecule in BCR-transduced signaling. The nature of FAK function in BCR-induced apoptosis of WEHI 231 lymphoblastoid cells was studied by overexpressing a C-terminal non-catalytic domain of FAK, termed focal adhesion targeted (FAT) domain. Clones overexpressing FAT protein exhibited a modified ability of induction of programmed cell death at low concentration threshold of anti-IgM antibodies, suggesting that FAK may play a role in modulating IgM-induced apoptotic signaling.
Rascan
I M
IM
Institute of Medical Sciences, University of Tokyo, Japan.
D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology; D017209:Apoptosis / Q000502:physiology*; D001402:B-Lymphocytes / Q000166:cytology* / Q000201:enzymology*; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology / Q000378:metabolism; D016393:Lymphoma, B-Cell; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D014407:Tumor Cells, Cultured
D000888:Antibodies, Anti-Idiotypic; D007075:Immunoglobulin M; C044203:anti-IgM; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human