title: Lessons from interleukin-deficient mice: the interleukin-1 system.
abstract: The study of cytokine-deficient mice has provided important information for a better understanding of inflammatory processes. In this report, the characterization of mice deficient for various components of the interleukin (IL)-1 system is reviewed. Results obtained by studying mice deficient for IL-1alpha, IL-1beta, IL-1 receptor antagonist, IL-1 receptor type I, IL-1 receptor accessory protein, IL-1 receptor-associated kinase, and the IL-1beta-converting enzyme caspase-1 are summarized. Because some of the components of the IL-1 system are shared with IL-18, similarities between IL-1beta and IL-18 are also discussed.
authors.affiliation: University of Colorado Health Sciences Center, Denver, CO 80262, USA.
authors.forename: G
authors.initials: G
authors.lastname: Fantuzzi
mesh_terms: D000818:Animals; D020170:Caspase 1 / Q000235:genetics / Q000276:immunology; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000235:genetics* / Q000276:immunology*; D053592:Interleukin-1 Receptor-Associated Kinases; D020382:Interleukin-18 / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D011494:Protein Kinases / Q000235:genetics / Q000276:immunology; D017472:Receptors, Interleukin-1 / Q000235:genetics* / Q000276:immunology*; D012795:Sialoglycoproteins / Q000235:genetics / Q000276:immunology
chemical_list: C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D020382:Interleukin-18; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D011494:Protein Kinases; D053592:Interleukin-1 Receptor-Associated Kinases; D020170:Caspase 1