Sesquiterpenoids from the fruits of Ferula kuhistanica and antibacterial activity of the constituents of F. kuhistanica.
Ethyl acetate extracts of the air-dried fruits of Ferula kuhistanica afforded three daucane esters: kuhistanicaol H, I and J, together with nine other known compounds. Their structures were established on the basis of spectroscopic evidence. Isolated compounds in this paper and previously reported compounds from the roots and stems of F. kuhistanica were tested for antibacterial activity. Some of them were selectively toxic against Gram-positive bacteria, including methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MSSA and MRSA).
Tamemoto
K
K
Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, 770-8505, Tokushima, Japan.
Takaishi
Y
Y
Chen
B
B
Kawazoe
K
K
Shibata
H
H
Higuti
T
T
Honda
G
G
Ito
M
M
Takeda
Y
Y
Kodzhimatov
O K
OK
Ashurmetov
O
O
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005309:Ferula / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D008712:Methicillin / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes; D008712:Methicillin