Trifluoperazine: a broad spectrum bactericide especially active on staphylococci and vibrios.
Trifluoperazine showed some significant antimicrobial activity when tested against 293 strains from two Gram-positive and eight Gram-negative genera. Minimum inhibitory concentrations of the drug were measured using an agar dilution technique. Forty six of 55 strains of Staphylococcus aureus were inhibited by 10-50 microg/ml of trifluoperazine. This drug also inhibited strains of Shigella spp., Vibrio cholerae and V. parahaemolyticus at a concentration of 10-100 microg/ml. Other bacteria including Pseudomonas spp. were moderately sensitive to trifluoperazine. In the in vivo studies this compound offered significant protection to Swiss albino mice at a concentration of 30 microg/mouse (P<0.001) when challenged with 50 median lethal dose of Salmonella typhimurium NCTC 74.
Mazumder
R
R
Department of Pharmaceutical Technology, Division of Microbiology, Jadavpur University, Calcutta 700 032, India.
Ganguly
K
K
Dastidar
S G
SG
Chakrabarty
A N
AN
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D012481:Salmonella Infections, Animal / Q000188:drug therapy / Q000382:microbiology; D012486:Salmonella typhimurium / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects*; D016019:Survival Analysis; D014268:Trifluoperazine / Q000494:pharmacology* / Q000627:therapeutic use; D014733:Vibrio / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D014268:Trifluoperazine