title: Determination of phenol and resorcinol using 1,3-dibromo-5,5-dimethylhydantoin (DBH) analogous to the Koppeschaar reaction. Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern, Part 6.
abstract: PH. EUR. 1997 determines phenol and resorcinol according to the Koppeschaar reaction using hepatotoxic and environmentally hazardous chloroform. Chlorinated hydrocarbons are not required when applying 1,3-dibromo-5,5-dimethylhydantoin (DBH). The reaction time for phenol can be reduced from 45 to 5 min. Blind values according to PH. EUR. 1997 result a systematic error of about -1.8%.
authors.affiliation: Institut für Pharmazeutische Chemie, Philipps-Universität, Marburg, Germany. Hilp@mailer.uni-marburg.de
authors.forename: M
authors.initials: M
authors.lastname: Hilp
mesh_terms: D001966:Bromine / Q000032:analysis; D004785:Environmental Pollutants / Q000032:analysis*; D005060:Europe; D006827:Hydantoins / Q000737:chemistry*; D007202:Indicators and Reagents; D010602:Pharmacopoeias as Topic; D010636:Phenols / Q000032:analysis*; D012118:Resorcinols / Q000032:analysis*; D012996:Solutions
chemical_list: D004785:Environmental Pollutants; D006827:Hydantoins; D007202:Indicators and Reagents; D010636:Phenols; D012118:Resorcinols; D012996:Solutions; D001966:Bromine; C056578:1,3-dibromo-5,5-dimethylhydantoin; C031389:resorcinol