title: Influence of parasympathetic non-adrenergic, non-cholinergic mechanisms on [3H]thymidine uptake in rat parotid salivary glands in response to mastication following upon a liquid regimen.
abstract: A role for parasympathetic non-adrenergic, non-cholinergic (NANC) mechanisms in parotid gland cell hyperplasia in response to mastication was investigated. Following a liquid regimen for 1 week, aiming at glandular inactivity, rats were offered hard chow for 2 h to throw their parotid glands into secretory activity. In response to the increasing demands, [3H]thymidine incorporation into the trichloroacetic acid-insoluble material increased by 76% in normally innervated glands, while there was no increase in glands parasympathetically denervated in advance. In innervated glands of rats pretreated with atropine and alpha- and beta-adrenoceptor blockers the increase was 46%. The results suggest a potential contribution of parasympathetic NANC mechanisms to the mitotic response of the parotid gland under natural feeding conditions.
authors.affiliation: Department of Pharmacology, Institute of Physiology and Pharmacology, Göteborg University, Box 431, 405 30, Göteborg, Sweden. jorgen.ekstrom@pharm.gu.se
authors.forename: J
authors.initials: J
authors.lastname: Ekström
authors.forename: A C
authors.initials: AC
authors.lastname: Reinhold
mesh_terms: D018674:Adrenergic Antagonists / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D018680:Cholinergic Antagonists / Q000494:pharmacology; D005260:Female; D006965:Hyperplasia; D008409:Mastication / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D009929:Organ Size; D017764:Parasympathectomy; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D010306:Parotid Gland / Q000166:cytology* / Q000294:innervation* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013936:Thymidine / Q000378:metabolism
chemical_list: D018674:Adrenergic Antagonists; D018680:Cholinergic Antagonists; D013936:Thymidine