title: Rearrangement of a 16alpha,17alpha-Epoxy-16beta-methylandrostane-17beta-carbothioic Acid to a 17beta-Mercapto-16beta-methylandrostane-17alpha,16alpha-carbolactone.
abstract: The 16alpha,17alpha-epoxy-16beta-methylandrostane-17beta-carbothioic acid 2b rearranges in solution at ambient temperature to the 17beta-mercapto-16beta-methylandrostane-17alpha,16alpha-carbolactone 6a, possibly via the spirocyclic alpha-thiolactone 5.
authors.affiliation: Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
authors.forename: Brian M.
authors.initials: BM
authors.lastname: Bain
authors.forename: Gordon H.
authors.initials: GH
authors.lastname: Phillipps
authors.forename: Panayiotis A.
authors.initials: PA
authors.lastname: Procopiou
authors.forename: Ian P.
authors.initials: IP
authors.lastname: Steeples
authors.forename: Richard J.
authors.initials: RJ
authors.lastname: Upton