[Role of cytokines in the metabolism of the extracellular matrix carbohydrate-protein components in patients of various ages with gastroduodenal ulcer].
The results of the study made in 43 patients with gastroduodenal ulcer have shown an increase in the production of proinflammatory cytokines (interleukin-1 beta, the tumor necrosis factor-alpha) and a decrease in the blood serum content of the transforming growth factor-beta, which events come to favour degradation processes in collagen and fucoglycoproteins with a concomitant increase in free oxyproline, serum protein-unbound fucose against the background of a suppressed synthesis of the extracellular matrix carbohydrate-protein components as evidenced by the serum diminished concentrations of protein-bound oxyproline and fucose, hexuronic acids, and hexosamines.
Fediv
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Kolomoiets'
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D000293:Adolescent; D000328:Adult; D002241:Carbohydrates / Q000737:chemistry*; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry*
D002241:Carbohydrates; D016207:Cytokines; D011506:Proteins