title: A Radical Cyclization Approach to Isoindolobenzazepines. Synthesis of Lennoxamine.
abstract: The alkaloid lennoxamine (1) was synthesized by transannular cyclization of a 10-membered lactam obtained by intramolecular addition of an aryl radical to a (trimethylsilyl)acetylene. The isoindolo[1,2-b][3]benzazepine skeleton present in lennoxamine was also obtained by means of regioselective 7-endo-trig radical cyclization of methylenephthalimidines.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de Santiago y Sección de Alcaloides del C. S. I. C. 15706 Santiago, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: Rodríguez
authors.forename: M. Magdalena
authors.initials: MM
authors.lastname: Cid
authors.forename: Carlos
authors.initials: C
authors.lastname: Saá
authors.forename: Luis
authors.initials: L
authors.lastname: Castedo
authors.forename: Domingo
authors.initials: D
authors.lastname: Domínguez