Crellastatin A: A Cytotoxic Bis-Steroid Sulfate from the Vanuatu Marine Sponge Crella sp.
A new nonsymmetric dimeric steroid, crellastatin A (1), was isolated from the Vanuatu Island marine sponge Crella sp. Structural assignment was accomplished through extensive 2D NMR spectroscopy. The stereochemistry of 1 was established from an analysis of ROESY experiments and from molecular mechanics and dynamics calculations. Crellastatin A (1), which possesses an unprecedented connection through the side chains, exhibits in vitro cytotoxic activity against NSCLC-N6 cells (IC(50) of 1.5 &mgr;g/mL).
D'Auria
Maria Valeria
MV
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli, via D. Montesano 49, 80131, Napoli, Italy, ORSTOM, Centre de Nouméa, New Caledonia, and Institut des Substances et Organismes de la Mer (ISOMER), Facultè de Pharmacie, University of Nantes, 1-Rue Gaston Veil, 44035 Nantes Cedex 01, France.
Giannini
Clelia
C
Zampella
Angela
A
Minale
Luigi
L
Debitus
Cécile
C
Roussakis
Christos
C