title: The effect of organic acids on the control of porcine post-weaning diarrhoea.
abstract: Post-weaning diarrhoea syndrome (PWDS) of piglets is caused mainly by Enterotoxigenic Escherichia coli (ETEC) strains. Six organic acids were tested for their efficacy in the control of PWDS, using a total of 384 weaned piglets, in eight groups, during a 28-day period. One group (negative control) was offered a diet free of antimicrobials, one group (positive control) was offered the same diet medicated with 44 p.p.m. of lincomycin and 44 p.p.m. spectinomycin (Lincospectin 22 premix, Upjohn), and six groups were offered feed supplemented with either 1.0 per cent propionic acid, 1.6 per cent lactic acid, 1.2 per cent formic acid, 1.2 per cent malic acid, 1.5 per cent citric acid or 1.5 per cent fumaric acid. Groups were compared with regard to the appearance of clinical signs, mortality, weight gain and feed conversion. All groups supplemented with organic acids had reduced incidence and severity of diarrhoea, and performed significantly better than the negative control group (P<0.05). At the end of the trial, ETEC strains were detected in the control group not receiving antibiotics but not in the treated group. Organic acids and especially lactic acid are a useful tool in controlling PWDS.
authors.affiliation: Clinic of Productive Animal Medicine, Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: V K
authors.initials: VK
authors.lastname: Tsiloyiannis
authors.forename: S C
authors.initials: SC
authors.lastname: Kyriakis
authors.forename: J
authors.initials: J
authors.lastname: Vlemmas
authors.forename: K
authors.initials: K
authors.lastname: Sarris
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D002264:Carboxylic Acids / Q000008:administration & dosage* / Q000378:metabolism; D003967:Diarrhea / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D019587:Dietary Supplements; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D004926:Escherichia coli / Q000254:growth & development; D004927:Escherichia coli Infections / Q000378:metabolism / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D008034:Lincomycin / Q000008:administration & dosage; D008297:Male; D000198:Spectinomycin / Q000008:administration & dosage; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D002264:Carboxylic Acids; C011012:lincospectin; D000198:Spectinomycin; D008034:Lincomycin