title: Is pancreas and/or spleen resection required in total gastrectomy for advanced gastric cancer?
abstract: OBJECTIVE
  Total gastrectomy for advanced gastric cancer is frequently combined with extended lymphadenectomy. This technique is easier when resection of distal pancreas and/or spleen is performed. We have tried to evaluate whether the resection of both structures and total gastrectomy in patients with advanced gastric cancer actually improve survival rates.
  
  
  METHODS
  From 1991 to 1999, 140 patients with advanced gastric cancer underwent total gastrectomy at the General Hospital of Albacete: 43 with simple total gastrectomy, 57 with total gastrectomy plus splenectomy and 40 with total gastrectomy plus distal pancreaticosplenectomy. Univariate and multivariate analysis were conducted in order to evaluate different prognostic factors and survival curves among the groups.
  
  
  RESULTS
  Survival rates of the three groups were compared for each factor, being only significant variables the degree of tumor infiltration in the gastric wall, the size of the tumor, the staging and the type of lymphatic infiltration. Neither splenectomy nor distal pancreaticosplenectomy improved the survival compared to simple total gastrectomy. Morbimortality rates increased with more aggressive surgical procedures, but differences were not significant.
  
  
  CONCLUSIONS
  Resection of distal pancreas and/or spleen plus total gastrectomy for advanced gastric cancer is associated to a greater number of isolated lymph nodes, but do not improve the survival of patients.
authors.affiliation: Service of General and Digestive Surgery, Complejo Hospitalario de Albacete, Albacete, Spain.
authors.forename: D
authors.initials: D
authors.lastname: García Picazo
authors.forename: P
authors.initials: P
authors.lastname: Cascales Sánchez
authors.forename: E
authors.initials: E
authors.lastname: García Blázquez
authors.forename: J M
authors.initials: JM
authors.lastname: Moreno Resina
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D005260:Female; D005743:Gastrectomy / Q000379:methods* / Q000401:mortality; D006801:Humans; D008197:Lymph Node Excision / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods* / Q000401:mortality; D013156:Splenectomy / Q000379:methods* / Q000401:mortality; D013274:Stomach Neoplasms / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate