title: Internalization of ionotropic glutamate receptors in response to mGluR activation.
abstract: Activation of group 1 metabotropic glutamate receptors (mGluRs) stimulates dendritic protein synthesis and long-term synaptic depression (LTD), but it remains unclear how these effects are related. Here we provide evidence that a consequence of mGluR activation in the hippocampus is the rapid loss of both AMPA and NMDA receptors from synapses. Like mGluR-LTD, the stable expression of this change requires protein synthesis. These data suggest that expression of mGluR-LTD is at least partly postsynaptic, and that a functional consequence of dendritic protein synthesis is the regulation of glutamate receptor trafficking.
authors.affiliation: Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Snyder
authors.forename: B D
authors.initials: BD
authors.lastname: Philpot
authors.forename: K M
authors.initials: KM
authors.lastname: Huber
authors.forename: X
authors.initials: X
authors.lastname: Dong
authors.forename: J R
authors.initials: JR
authors.lastname: Fallon
authors.forename: M F
authors.initials: MF
authors.lastname: Bear
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D003712:Dendrites / Q000378:metabolism; D004594:Electrophysiology; D004705:Endocytosis / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans; D018091:Receptors, AMPA / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012118:Resorcinols / Q000494:pharmacology; D013569:Synapses / Q000378:metabolism; D016704:Synapsins / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects; D014966:Xanthenes / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D018691:Excitatory Amino Acid Antagonists; C114624:LY 341495; D011500:Protein Synthesis Inhibitors; D018091:Receptors, AMPA; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D012118:Resorcinols; D016704:Synapsins; D014966:Xanthenes; D008734:Methoxyhydroxyphenylglycol; C079215:3,5-dihydroxyphenylglycine; D003513:Cycloheximide; D005998:Glycine; C010117:3,4-dihydroxyphenylglycol