Interactions of diuretics with a neutral temperature-responsive polymer: study by capillary electroporesis and dynamic light scattering.
Interactions between diuretics and a recently synthesized temperature-responsive neutral copolymer, poly(N-isopropyl acrylamide) (PNIPA) grafted with poly(ethyleneoxide) (PEO) (PNIPA-g-PEO) were investigated by capillary electrophoresis and dynamic light scattering (DLS). At ambient temperatures, the copolymer takes an open, random coil conformation, but above the lower critical solution temperature (LCST), the polymer shrinks and forms large, stable aggregates. Among the diuretics studied, hydrochlorothiazide was detected to bind to PNIPA-g-PEO.
Wiedme
S K
SK
Department of Chemistry, University of Helsinki, Finland.
Riekkola
M L
ML
Tenhu
H
H
D000180:Acrylic Resins / Q000737:chemistry*; D001539:Bendroflumethiazide / Q000737:chemistry; D001581:Benzothiadiazines / Q000737:chemistry; D002740:Chlorothiazide / Q000737:chemistry; D004232:Diuretics; D016503:Drug Delivery Systems; D019075:Electrophoresis, Capillary; D006852:Hydrochlorothiazide / Q000737:chemistry; D008968:Molecular Conformation; D009391:Nephelometry and Turbidimetry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D049993:Sodium Chloride Symporter Inhibitors / Q000737:chemistry*; D013696:Temperature; D014237:Trichlormethiazide / Q000737:chemistry
D000180:Acrylic Resins; D001581:Benzothiadiazines; D004232:Diuretics; D011108:Polymers; D049993:Sodium Chloride Symporter Inhibitors; C441456:poly(N-isopropyl acrylamide-co-ethyleneoxide); D006852:Hydrochlorothiazide; C004463:benzothiazide; D011092:Polyethylene Glycols; D001539:Bendroflumethiazide; D002740:Chlorothiazide; D014237:Trichlormethiazide