SorCS1, a member of the novel sorting receptor family, is localized in somata and dendrites of neurons throughout the murine brain.
The expression of the sorCS1 protein in the central nervous system of adult mice was studied by immunohistochemistry. A detailed mapping revealed a distribution of sorCS1 immunoreactivity in a widespread population of neurons throughout the brain. Two different types of cellular localization were observed. Many neurons exhibited a punctate cytoplasmic staining which extended into the dendrites, in other neurons sorCS1 immunoreactivity was associated with the plasma membrane. This suggests variable functions for sorCS1 in the neurons of the brain.
Hermey
G
G
Zentrum für Molekulare Neurobiologie, Universität Hamburg, Martinistrasse 52, D-20246 Hamburg, Germany.
Riedel
I B
IB
Rezgaoui
M
M
Westergaard
U B
UB
Schaller
C
C
Hermans-Borgmeyer
I
I
D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000166:cytology*; D002462:Cell Membrane / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry; D003712:Dendrites / Q000737:chemistry*; D005656:Fungal Proteins / Q000737:chemistry; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000737:chemistry* / Q000648:ultrastructure; D017434:Protein Structure, Tertiary; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000737:chemistry / Q000276:immunology; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins
D005656:Fungal Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; C087335:PEP1 protein, S cerevisiae; D011956:Receptors, Cell Surface; C000595029:SORCS1 protein, mouse; D029701:Saccharomyces cerevisiae Proteins; C402822:SorCS protein, mouse; D033921:Vesicular Transport Proteins