Synthesis and microbiological activity of some 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives.
The synthesis and physicochemical properties of 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives are described. These new compounds were synthesised by alkylation in 4-N position and acylation and/or alkylation of 6-NH2 by phase transfer catalysis. Acid hydrolysis of 6-alkylacylamino group yielded 6-alkylamino-4-butyl-2H-benzo[1,4]thiazin-3-ones. The antimicrobial in vitro activity was determined on five compounds.
Guarda
V L
VL
Escola de Farmácia, Universidade Federal de Ouro Preto, MG, Brazil. vera@cpd.ufop.br
Perrissin
M
M
Thomasson
F
F
Ximenes
E A
EA
Galdino
S L
SL
Pitta
I R
IR
Luu-Duc
C
C
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D013843:Thiazines