title: Synthesis of a New Ligand for Metal Assembly to a Selective Receptor.
abstract: Diarylphosphinic acid 2, bearing two ethylenediamine groups, was designed with the aim of assembly to form a hydrophobic cavity upon binding to metals. The new ligand was prepared in optically active form from phenylalanine by an efficient sequence which required chromatography only for the P-C bond forming steps. Versatile intermediates in the synthesis are described. Complexes of this ligand with Zn(2+) were shown to bind closely related aromatic guests bearing anionic tethered groups with 1000-fold discrimination.
authors.affiliation: Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201.
authors.forename: Alan W.
authors.initials: AW
authors.lastname: Schwabacher
authors.forename: Andrei D.
authors.initials: AD
authors.lastname: Stefanescu
authors.forename: Atiq ur
authors.initials: A
authors.lastname: Rehman