title: 3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors.
abstract: Design, synthesis and structure-activity relationship of a class of 3-aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrroles as farnesyltransferase inhibitors are described. Compound 7 inhibits farnesyltransferase with an IC(50) value of 4.6 nM.
authors.affiliation: Life Science R & D, LGCI, Science Town, Taejon 305-380, South Korea.
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: Y
authors.initials: Y
authors.lastname: Shin
authors.forename: W
authors.initials: W
authors.lastname: Jung
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Park
authors.forename: S
authors.initials: S
authors.lastname: Ro
authors.forename: H H
authors.initials: HH
authors.lastname: Chung
authors.forename: J S
authors.initials: JS
authors.lastname: Koh
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C443752:3-aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole; D004791:Enzyme Inhibitors; D007093:Imidazoles; D011758:Pyrroles; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase