title: Gingival tissue inflammatory response following treatment with chemical retraction agents in Beagle dogs.
abstract: A normal finding of a clinically healthy gingiva is minimal inflammatory infiltration of subepithelial connective tissue which increases after exposure of gingiva to retraction agents. The study investigates and compares the inflammatory potential of four retraction agents on the gingival connective tissue. The gingiva of Beaagle dogs was exposed for 10 minutes to chemical agents. Byopsies were taken one hour, 24 hours and 7 days after treatment. Morphometric analysis of treated and control gingiva was performed on parasagittal tissue sections to compare the gingival tissue inflammatory potential of four retraction chemicals. Retraction agents produced no significant effect on connective tissue under the junctional epithelium. On the other hand the connective tissue under sulcular epithelium exhibits extensive inflammatory infiltration. The most aggressive retraction agent being Racestyptine and the least Visine, which therefore could be recommended for clinical practice.
authors.affiliation: Centre of Fixed Prosthodontics, Dental Department, University Medical Centre, Ljubljana, Slovenia.
authors.forename: I
authors.initials: I
authors.lastname: Kopac
authors.forename: E
authors.initials: E
authors.lastname: Cvetko
authors.forename: Z
authors.initials: Z
authors.lastname: Pavlica
authors.forename: L
authors.initials: L
authors.lastname: Marion
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000534:Alum Compounds / Q000494:pharmacology; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000494:pharmacology*; D000818:Animals; D001252:Astringents / Q000494:pharmacology*; D001706:Biopsy; D002712:Chlorides / Q000494:pharmacology*; D004285:Dogs; D005881:Gingiva / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D005891:Gingivitis / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D007093:Imidazoles / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D017607:Aluminum Compounds; D001252:Astringents; D002712:Chlorides; D007093:Imidazoles; D013566:Sympathomimetics; C041524:aluminum sulfate; D000077410:Aluminum Chloride; C005810:tetrahydrozoline