EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes.
Epstein-Barr virus (EBV) has the ability to immortalize B cells. A viral key protein for immortalization is the transactivator EBNA2 that controls expression of several viral and cellular genes. EBNA2 is tethered to promoters by interacting with the cellular repressor RBP-J. This resembles the physiological activation of RBP-J-repressed promoters by activated Notch receptors (Notch-IC). Since EBNA2 and Notch-IC have been shown to be partially interchangeable in regard to activation of target genes in B cell lines and modulation of differentiation processes it is conceivable that EBNA2 is a biological equivalent of an activated Notch receptor.
Zimber-Strobl
U
U
Institute for Genetics, University of Cologne, 50931 Cologne, Germany. u.strobl@uni-koeln.de
Strobl
L J
LJ
D001402:B-Lymphocytes / Q000166:cytology* / Q000821:virology*; D002470:Cell Survival; D002472:Cell Transformation, Viral; D004268:DNA-Binding Proteins / Q000378:metabolism; D019309:Epstein-Barr Virus Nuclear Antigens / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D009687:Nuclear Proteins; D051880:Receptors, Notch; D015398:Signal Transduction; D015533:Transcriptional Activation; D014764:Viral Proteins
D004268:DNA-Binding Proteins; C402641:EBNA-2 protein, Human herpesvirus 4; D019309:Epstein-Barr Virus Nuclear Antigens; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D008565:Membrane Proteins; D009687:Nuclear Proteins; C497570:RBPJ protein, human; D051880:Receptors, Notch; D014764:Viral Proteins