Effect of citalopram and buspirone on the antinociceptive action of analgesic drugs.
The influence of citalopram (20 mg/kg i.p.) and buspirone (3 mg/kg i.p.) on analgesic effects of morphine (10 mg/kg i.p.), metamizole (500 mg/kg i.p.) and indomethacin (10 mg/kg) was studied with tail-flick and hot-plate tests on mice. The research studies were further conducted with multiple (14 days) drug dosage. The results indicate that citalopram and buspirone decrease analgesic effects of morphine, metamizole and indomethacin. This mode of action is more pronounced in case of a single dose than after multiple doses.
Pakulska
W
W
Department of Pharmacodynamics, Medical University of Lódź, Poland.
Czarnecka
E
E
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D002065:Buspirone / Q000494:pharmacology*; D015283:Citalopram / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy* / Q000523:psychology; D010147:Pain Measurement / Q000187:drug effects
D000700:Analgesics; D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D015283:Citalopram; D002065:Buspirone