G protein signaling and asymmetric cell division.
Asymmetric cell division depends on the polarization of the dividing cell for the correct alignment of the mitotic spindle and the localization of cytoplasmic determinants. Receptor-independent activation of heterotrimeric G proteins by the Drosophila GoLoco protein Partner of Inscuteable seems to represent a novel mechanism to control these events.
Knust
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Institut für Genetik, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. knust@uni-duesseldorf.de
D000818:Animals; D018797:Cell Cycle Proteins; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D004330:Drosophila; D029721:Drosophila Proteins; D019204:GTP-Binding Proteins / Q000378:metabolism* / Q000502:physiology*; D019476:Insect Proteins / Q000378:metabolism; D008954:Models, Biological; D010641:Phenotype; D011485:Protein Binding; D015398:Signal Transduction
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; C405164:Pins protein, Drosophila; D019204:GTP-Binding Proteins