title: Surgical treatment for tubal disease in women due to undergo in vitro fertilisation.
abstract: BACKGROUND
  Tubal disease, and particularly hydrosalpinx, has a detrimental effect on the outcome of in-vitro fertilisation (IVF). It has been less clear whether surgical intervention for tubal disease prior to IVF is effective in improving the likelihood of successful outcome. Most data are retrospective or poorly controlled. To date no single prospective randomised trial has shown a significant benefit from such surgical treatment prior to IVF.
  
  
  OBJECTIVE
  To assess the value of surgical treatment for tubal disease prior to IVF.
  
  
  METHODS
  The search strategy of the Menstrual Disorders and Subfertility Group was used for the identification of relevant randomised controlled trials.
  
  
  METHODS
  All trials where a surgical treatment for tubal disease was compared with a control group generated by randomisation were considered for inclusion in the review.
  
  
  METHODS
  Three randomised controlled trials were identified and included in this review, after an attempt to obtain further information from the authors of all three trials. All trials were assessed for quality criteria. The studied outcomes were live birth (and ongoing pregnancy), pregnancy, ectopic pregnancy, miscarriage, multiple pregnancy, complications, implantation rate and the proportion of IVF cycles resulting in embryo transfer.
  
  
  RESULTS
  The odds of pregnancy (OR 1.75, 95%CI 1.07, 2.86) and of ongoing pregnancy and live birth (OR 2.13, 95%CI 1.24, 3.65) were increased with laparoscopic salpingectomy for hydrosalpinges prior to IVF. There was no significant difference in the odds of ectopic pregnancy (OR 0.42, 95%CI 0.08, 2.14), miscarriage (OR 0.49, 95%CI 0.16, 1.52), treatment complications (OR 5.80, 95%CI 0.35, 96.79) or implantation rate (OR 1.34, 95%CI 0.87, 2.05). No data were available concerning the odds of multiple pregnancy or the proportion of IVF cycles resulting in embryo transfer.
  
  
  CONCLUSIONS
  Laparoscopic salpingectomy should be considered for all women with hydrosalpinges prior to IVF treatment. Currently unilateral salpingectomy for a unilateral hydrosalpinx (bilateral salpingectomy for bilateral hydrosalpinges) should be recommended, although this requires further evaluation. Further randomised trials are required to assess other surgical treatments for hydrosalpinx, such as salpingostomy, tubal occlusion or needle drainage of a hydrosalpinx at oocyte retrieval. The role of surgery for tubal disease in the absence of a hydrosalpinx is unclear and merits further evaluation.
authors.affiliation: Obstetrics & Gynaecology Department, National Women's Hospital, Claude Road, Epsom, Auckland, New Zealand, 1003. n.johnson@auckland.ac.nz
authors.forename: N P
authors.initials: NP
authors.lastname: Johnson
authors.forename: W
authors.initials: W
authors.lastname: Mak
authors.forename: M C
authors.initials: MC
authors.lastname: Sowter
mesh_terms: D005184:Fallopian Tube Diseases / Q000601:surgery*; D005187:Fallopian Tubes / Q000601:surgery*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D016032:Randomized Controlled Trials as Topic