The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men.
OBJECTIVE
Testing association of the Asn363Ser variant of the glucocorticoid gene with measures of obesity and weight gain.


METHODS
741 obese subjects (BMI > or = 31 kg/m(2) at selection) and 854 random control subjects from the same population, examined at draft board examination and after on average 27.4+/- y. A lean control group (n=351) was further selected as the fraction from the cohort group having a BMI below 25.0 kg/m(2) at the latest examination.


METHODS
Using PCR-RFLP subjects were genotyped for the Asn363Ser variant and grouped according to genotype.


RESULTS
The prevalence of the Ser363 allele was 4.7% (95% Cl: 3.3-6.2%) among the obese, 4.1% (2.7-5.5%) among the random cohort subjects and 4.3% (2.1-6.5%) among lean control subjects, respectively, showing no significant differences between the groups (P > 0.1). Furthermore, no differences in BMI, waist-hip ratio or weight gain were seen within any of the groups when defined according to the glucocorticoid receptor genotype.


CONCLUSIONS
In the examined population this marker is not a relevant predictor of obesity.
Echwald
S M
SM
Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark. SME@hagedorn.dk
Sørensen
T I
TI
Andersen
T
T
Pedersen
O
O
D000328:Adult; D000483:Alleles; D001824:Body Constitution / Q000235:genetics; D015992:Body Mass Index; D015331:Cohort Studies; D005387:Finland; D005838:Genotype; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D015430:Weight Gain / Q000235:genetics*
D011965:Receptors, Glucocorticoid