title: Dihydropyrromethenones by Pd(0)-Mediated Coupling of Iodopyrroles and Acetylenic Amides. Synthesis of the A,B-Ring Segment of Phytochrome.
abstract: Dihydropyrromethenone derivative 32b, which constitutes the A,B-ring segment of phytochrome (6), has been prepared in enantiomerically pure form beginning with acetylenic amide 47b and iodopyrrole 27. The key steps involved the TBAF-catalyzed 5-exo-dig cyclization of the acetylenic pyrrole 48b, followed by thia-Mitsunobu inversion of the resulting alcohol derivative 31b.
authors.affiliation: Hall-Atwater Laboratories, Wesleyan University, Middletown, Connecticut 06459-0180.
authors.forename: Peter A.
authors.initials: PA
authors.lastname: Jacobi
authors.forename: Jiasheng
authors.initials: J
authors.lastname: Guo
authors.forename: S.
authors.initials: S
authors.lastname: Rajeswari
authors.forename: Wanjun
authors.initials: W
authors.lastname: Zheng