The role of high-density lipoproteins in oxidation and inflammation.
High-density lipoproteins (HDL) in the basal state are anti-inflammatory, capable of destroying oxidized lipids that generate an inflammatory response. However, HDL during acute inflammation are altered and become pro-inflammatory. This "chameleon-like" nature of HDL is considered to be due to the complex composition of HDL. The data reviewed here demonstrate the key role of HDL in modulating inflammation and its implications for atherogenesis.
Van Lenten
B J
BJ
Department of Medicine, University of California, Los Angeles, California, USA. bvanlent@mednet.ucla.edu
Navab
M
M
Shih
D
D
Fogelman
A M
AM
Lusis
A J
AJ
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000502:physiology*; D015227:Lipid Peroxidation / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000502:physiology*
D018836:Inflammation Mediators; D008075:Lipoproteins, HDL