An automated technique for measuring hippocampal volumes from MR imaging studies.
We describe an automated volumetric measure of the hippocampus obtained with software called the Knowledge-Guided MRI Analysis Program (KGMAP). Postmortem MR images from 56 participants in the Nun Study were used to validate the measure. KGMAP-determined volumes strongly correlated with those obtained with manual tracings and neurofibrillary pathologic findings of Alzheimer disease in the hippocampus. KGMAP provides a rapid and accurate estimate of hippocampal volume that is suitable for use in clinical practice.
Gosche
K M
KM
Institute on Aging, University of South Florida, Tampa 33612-3899, USA.
Mortimer
J A
JA
Smith
C D
CD
Markesbery
W R
WR
Snowdon
D A
DA
D000544:Alzheimer Disease / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D012984:Software