title: Lewis Acid-Promoted Coupling Reactions of Acid Chlorides with Organoaluminum and Organozinc Reagents.
abstract: An efficient synthesis of alpha,beta-unsaturated ketones by the reaction of acid chlorides with trialkylaluminum (1/3 mole equiv) in the presence of AlCl(3) (1 mol equiv) is described. Dialkylzincs were also useful and are easier to prepare than trialkylaluminum. Reaction of RCOCl with R'AlCl(2) or R'(2)AlCl gave R'COR, without AlCl(3), in high yield.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Arisawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Torisawa
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kawahara
authors.forename: Masamichi
authors.initials: M
authors.lastname: Yamanaka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nishida
authors.forename: Masako
authors.initials: M
authors.lastname: Nakagawa