title: Highly Efficient Palladium-Catalyzed Boronic Acid Coupling Reactions in Water: Scope and Limitations.
abstract: The "ligandless" palladium acetate-catalyzed Suzuki cross-coupling reaction of ArX with aryl- and vinylboronic acids in water without organic cosolvent in the presence of tetrabutylammonium bromide is reported. Aryl bromides give high yields and considerably accelerate the coupling. A wide variety of functional groups can be tolerated. Aryl iodides, however, give incomplete conversion and aryl triflate coupling shows no improvement over reported conditions.
authors.affiliation: Research Center Sanofi-Midy, via Piranesi, 38 20137 Milan, Italy.
authors.forename: D.
authors.initials: D
authors.lastname: Badone
authors.forename: M.
authors.initials: M
authors.lastname: Baroni
authors.forename: R.
authors.initials: R
authors.lastname: Cardamone
authors.forename: A.
authors.initials: A
authors.lastname: Ielmini
authors.forename: U.
authors.initials: U
authors.lastname: Guzzi