Enantioseparation of chiral vasodilator drug isoxsuprine in high-performance liquid chromatography and capillary electrophoresis.
Two independent methods using high-performance liquid chromatography (HPLC) on polysaccharide type chiral stationary phase (CSP) and capillary electrophoresis (CE) with native and derivatised cyclodextrins (CD) have been proposed for the enantioseparation of chiral vasodilator drug isoxsuprine (ISP). The methods have been compared from the viewpoint of separation characteristics (efficiency, sensitivity, analysis time, costs, etc.).
Chankvetadze
Bezhan
B
Institute of Pharmaceutical Chemistry, University of Münster, Hittorfstr. 58-62, 48149, Münster, Germany.
Burjanadze
Naira
N
Blaschke
Gottfried
G
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000191:economics / Q000379:methods; D007556:Isoxsuprine / Q000302:isolation & purification*; D015394:Molecular Structure; D011134:Polysaccharides; D013237:Stereoisomerism; D014665:Vasodilator Agents / Q000302:isolation & purification*
D003505:Cyclodextrins; D011134:Polysaccharides; D014665:Vasodilator Agents; D007556:Isoxsuprine