Conditioned taste aversion and c-Fos expression in cholestatic rats.
Rats in which a ligation of the bile duct (BDL) was paired with a saccharin taste developed a persistent conditioned taste aversion in both preference and taste reactivity tests. All BDL animals regardless of pairing had increased c-Fos-like immunoreactivity (FLI) in the area postrema and the nucleus of the solitary tract. This FLI may reflect the illness associated with BDL, but there was no evidence of conditioned FLI.
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Department of Psychology, University of Washington, Seattle, WA 98195-1525, USA.
Fitts
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D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001652:Bile Ducts / Q000293:injuries / Q000601:surgery; D002628:Chemoreceptor Cells / Q000166:cytology / Q000378:metabolism; D002779:Cholestasis / Q000150:complications*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D020546:Fourth Ventricle / Q000166:cytology / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D020318:Rats, Long-Evans; D012439:Saccharin / Q000494:pharmacology; D017552:Solitary Nucleus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013649:Taste / Q000187:drug effects / Q000502:physiology*
D016760:Proto-Oncogene Proteins c-fos; D012439:Saccharin