Aminophylline does not protect against radiocontrast nephropathy in patients undergoing percutaneous angiographic procedures.
BACKGROUND
Radiocontrast nephropathy (RCN) is one of the leading causes of hospital-acquired acute renal insufficiency. Adenosine, a renal vasoconstrictor, is thought to play a role in RCN. In this study, aminophylline, a non-selective adenosine-competitive inhibitor, was evaluated as a potential agent to protect against RCN.


METHODS
Twenty-six patients treated with 200 mg intravenous aminophylline immediately prior to percutaneous coronary and peripheral procedures were individually matched to 26 controls for baseline creatinine (Cr), diabetes mellitus and amount of contrast used. The aminophylline-treated group was also similar to control with respect to baseline ejection fraction, amount of post-procedure hydration, age, blood pressure and the use of nephrotic drugs.


RESULTS
There was no significant difference between the change from baseline Cr to peak measured Cr in either cases or controls. Also, when a change in Cr > or =25% from baseline was considered significant, Fisher's exact test did not show a difference between the 2 groups.


CONCLUSIONS
Aminophylline does not appear to add a protective role in preventing against RCN in patients undergoing percutaneous angiographic procedures.
Shammas
N W
NW
Cardiovascular Medicine, P.C., 1236 E. Rusholme, Suite 300, Davenport, IA 52803, USA. Shammas@home.com
Kapalis
M J
MJ
Harris
M
M
McKinney
D
D
Coyne
E P
EP
D000368:Aged; D000369:Aged, 80 and over; D000628:Aminophylline / Q000008:administration & dosage* / Q000037:antagonists & inhibitors*; D016022:Case-Control Studies; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D017211:Treatment Failure
D003287:Contrast Media; D010726:Phosphodiesterase Inhibitors; D000628:Aminophylline; D003404:Creatinine