Antiganglioside antibodies in acute self-limiting ataxic neuropathy: incidence and significance.
Antidisialosyl antibodies have been previously associated to chronic and acute ataxic neuropathies. We studied the presence of these antibodies in nine patients with acute self-limiting ataxic neuropathy (ASLAN) using ELISA and TLC immunodetection. One patient showed serum IgG immunoreactivity against gangliosides GD3 and GQ1b. The patient's IgG was able to bind to the nodes of Ranvier on frozen human dorsal root. Our studies confirmed that antidisialosyl reactivity is associated to ataxic neuropathy and its specific binding to the dorsal root could explain the predominant sensory involvement. Nevertheless, the low incidence of this reactivity indicates that a different pathogenic mechanism should be involved in most ASLAN patients.
Serrano-Munuera
C
C
Department of Neurology, Institut de Recerca, Hospital de la Sta. Creu i St. Pau, Universitat Autonoma, Sant Antoni Ma Claret, 167, Barcelona 08025, Spain.
Gallardo
E
E
Rojas
R
R
De Luna
N
N
González-Masegosa
A
A
Martí-Massó
J F
JF
Martínez-Matos
A
A
Ortíz
N
N
Reñé
R
R
Berciano
J
J
Grau
J M
JM
Willison
H J
HJ
Graus
F
F
Illa
I
I
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001259:Ataxia / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005732:Gangliosides / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000276:immunology* / Q000473:pathology; D011901:Ranvier's Nodes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D013126:Spinal Nerve Roots / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G