Genetic mechanisms of sudden cardiac death.
When there is a genetic mutation in a major cardiac protein, SCD is often an unfortunate part of the clinical phenotype. In the majority of common cardiac diseases, even though the nature or degree of genetic influence is not understood their importance cannot be denied. Although advancing by one gene or gene interaction at a time is arduous, it is the only apparent way to begin to unravel as complex a clinic syndrome as SCD.
Cawthon
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MUSC Division of Cardiology, 96 Jonathan Lucas Drive, Ste. 816, P.O. Box 250623, Charleston, SC 29425-5799, USA.
O'Brien
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D016757:Death, Sudden, Cardiac / Q000209:etiology; D005826:Genetics, Medical; D006801:Humans