title: A new volumetric evaluation of partial splenic embolization for hypersplenism in biliary atresia.
abstract: OBJECTIVE
  Partial splenic embolization (PSE) has become an important therapeutic modality in the management of hypersplenism in biliary atresia (BA). Fifty percent to 80% of spleen is usually devascularized by embolization. The functional outcome, however, has not been correlated with embolized volume of the spleen. The authors propose a new, reliable method of predicting functional outcome using nonembolized volume of the spleen (NEVS) as an index.
  
  
  METHODS
  Between January 1993 and July 2000, 11 children with BA (2 boys and 9 girls, aged 5 to 10 years) underwent 12 PSE procedures. The follow-up period ranged from 6 to 77 months. The NEVS was calculated by enhanced computed tomography (CT) images, and an index was calculated by dividing NEVS with the predicted splenic volume for body weight (standardized NEVS ratio) 2 weeks after PSE.
  
  
  RESULTS
  Splenic volumes before PSE ranged from 312 to 1,201 cm(3) (mean, 875.8 cm(3)). NEVS ranged from 140 to 485 cm(3) (mean, 340 cm(3)). Standardized NEVS ratio ranged from 2.21 to 7.22 (mean, 4.25). The platelet counts with standardized NEVS ratio below 5.0 (group I) and above 5.0 (group II) were 15.1 x 10(4)/mm(3) and 7.2 x 10(4)/mm(3) at 6-month follow-up, respectively.
  
  
  CONCLUSIONS
  (1) Nonembolized volumetric evaluation is useful in predicting the functional outcome of PSE. (2) Reembolization is indicated for the patients with standardized NEVS above 5.0.
authors.affiliation: Department of Surgery, Kobe Children's Hospital, 1-1-1 Takakuradai, Suma-ku, Kobe 654-0081, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Obatake
authors.forename: T
authors.initials: T
authors.lastname: Muraji
authors.forename: K
authors.initials: K
authors.lastname: Kanegawa
authors.forename: S
authors.initials: S
authors.lastname: Satoh
authors.forename: E
authors.initials: E
authors.lastname: Nishijima
authors.forename: C
authors.initials: C
authors.lastname: Tsugawa
mesh_terms: D001656:Biliary Atresia / Q000097:blood / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006971:Hypersplenism / Q000097:blood / Q000628:therapy*; D008297:Male; D010976:Platelet Count; D013154:Spleen / Q000098:blood supply*; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications