title: Precision bone and muscle loss measurements by advanced, multiple projection DEXA (AMPDXA) techniques for spaceflight applications.
abstract: An advanced, multiple projection, dual energy x-ray absorptiometry (AMPDXA) scanner system is under development. The AMPDXA is designed to make precision bone and muscle loss measurements necessary to determine the deleterious effects of microgravity on astronauts as well as develop countermeasures to stem their bone and muscle loss. To date, a full size test system has been developed to verify principles and the results of computer simulations. Results indicate that accurate predictions of bone mechanical properties can be determined from as few as three projections, while more projections are needed for a complete, three-dimensional reconstruction.
authors.affiliation: The Johns Hopkins Unversity Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, Maryland 20723-6099, USA.
authors.forename: H K
authors.initials: HK
authors.lastname: Charles
authors.forename: T J
authors.initials: TJ
authors.lastname: Beck
authors.forename: H S
authors.initials: HS
authors.lastname: Feldmesser
authors.forename: T C
authors.initials: TC
authors.lastname: Magee
authors.forename: T S
authors.initials: TS
authors.lastname: Spisz
authors.forename: V L
authors.initials: VL
authors.lastname: Pisacane
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000328:Adult; D000337:Aerospace Medicine / Q000295:instrumentation; D000368:Aged; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009133:Muscular Atrophy / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013026:Space Flight / Q000295:instrumentation*; D014893:Weightlessness