Fenoldopam in the prevention of contrast media-induced acute renal failure.
OBJECTIVE
To examine the role of fenoldopam in prevention of contrast media-induced acute renal failure (ARF).


METHODS
A literature search of MEDLINE (from 1966 to October 2000) was performed using the following title search terms: fenoldopam, contrast, and renal failure.


METHODS
English-language human studies, abstracts, and pertinent animal data were reviewed.


RESULTS
Small trials using animals with artificially induced ARF receiving fenoldopam demonstrated improvement in renal function. Preliminary trials in healthy humans have also demonstrated similar results using doses not affecting systemic blood pressure.


CONCLUSIONS
Fenoldopam may have a role in the management of ARF induced by contrast dye. However, due to the lack of a large-scale study it cannot be routinely recommended.
Chu
V L
VL
Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, New York, NY 11201-5497, USA.
Cheng
J W
JW
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D018491:Dopamine Agonists / Q000627:therapeutic use*; D018818:Fenoldopam / Q000627:therapeutic use*; D006801:Humans; D012079:Renal Circulation / Q000502:physiology
D003287:Contrast Media; D018491:Dopamine Agonists; D018818:Fenoldopam