New acetophenone glucosides isolated from extracts of Helichrysum italicum with antiinflammatory activity.
Three new acetophenone glucosides (4-6), three known aglycons (1-3), and a benzo-gamma-pyrone glucoside (7) were isolated from the CH(2)Cl(2), EtOAc, and BuOH extracts from the aerial parts of Helichrysum italicum. All the compounds tested showed antiinflammatory activity in a 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse ear edema test, and the ID(50) value of compound 2, the most active compound, was determined.
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Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.
Recio
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Giner
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Máñez
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JL
D000098:Acetophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D013030:Spain; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013755:Tetradecanoylphorbol Acetate; D001617:beta-Glucosidase / Q000378:metabolism
C440950:12-hydroxytremetone-12-O-beta-D-glucopyranoside; C440951:3-(2-hydroxyethyl)acetophenone-4-O-beta-D-glucopyranoside; C440949:3-(3-methyl-2-butenyl)acetophenone-4-O-beta-D-glucopyranoside; D000098:Acetophenones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; D001617:beta-Glucosidase; D013755:Tetradecanoylphorbol Acetate; D007213:Indomethacin