title: Ocular injuries from household chemicals: early signs as predictors of recovery.
abstract: We undertook a study of patients with nonsevere ocular injuries from chemicals used in the home to (1) establish the frequency of presentation to the Accident and Emergency (A&E) Department; (2) assess and grade any common symptoms and signs of injury; and (3) evaluate cytokine concentrations in the preocular fluid as markers of toxicity. Of the 216 reviewed chemical injuries, 85% were sustained by adults (twice as many men than women). Chemicals implicated were: alkalis, cleaners, organic solvents, personal hygiene products, contact lens solutions, and disinfectants. Conjunctival redness occurred in 80% of cases, irrespective of chemical. Low correlations were obtained for the extent, type, and degree of epithelial damage in different areas of the lower lid and bulbar conjunctiva. With one exception, interleukin (IL)1beta and IL10 levels were not different in control and injured eyes, whereas IL6 was significantly elevated above uninjured levels. We have shown that interleukins, as representatives of signal chemicals, can be noninvasively sampled and reliably measured in tears after chemical injury. An indication of injury is obtained clearly from IL6 levels in tears, and there is a hint that the pattern of IL1beta/IL10 might help discriminate between levels of severity. A larger study is needed to verify these results.
authors.affiliation: University of Bristol, Division of Ophthalmology, Bristol Eye Hospital, Bristol, United Kingdom. mon.berry@bristol.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Berry
authors.forename: D
authors.initials: D
authors.lastname: Jeffreys
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002057:Burns, Chemical / Q000175:diagnosis* / Q000378:metabolism; D003228:Conjunctiva / Q000187:drug effects / Q000378:metabolism; D003315:Cornea / Q000187:drug effects / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005126:Eye Burns / Q000139:chemically induced* / Q000378:metabolism; D005143:Eyelids / Q000187:drug effects / Q000378:metabolism; D005260:Female; D015386:Hazardous Substances / Q000009:adverse effects*; D006795:Household Products / Q000009:adverse effects*; D006801:Humans; D007378:Interleukins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D013666:Tears / Q000378:metabolism
chemical_list: D015415:Biomarkers; D015386:Hazardous Substances; D007378:Interleukins