Pre-mRNA processing: insights from nonsense.
In eukaryotic cells, translation is thought to be confined to cytoplasm, but two recent studies have challenged this notion, one showing that an mRNA's open reading frame influences nuclear events as early as release from the site of transcription, and the other by providing evidence for protein synthesis within the nucleus.
Brogna
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Brandeis University, Department of Biology, Waltham, Massachusetts 02454, USA. brogna@brandeis.edu
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D018389:Codon, Nonsense / Q000235:genetics*; D004023:Dictyostelium / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D016366:Open Reading Frames / Q000235:genetics* / Q000502:physiology; D014176:Protein Biosynthesis / Q000235:genetics* / Q000502:physiology; D012322:RNA Precursors / Q000235:genetics* / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics* / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D018389:Codon, Nonsense; D012322:RNA Precursors; D012333:RNA, Messenger