title: Cytotoxic activity and QSAR of N,N'-diarylalkanediamides.
abstract: The one- and two-step syntheses of N,N'-(dinitrophenyl)alkanediamides and N,N'-(diaminophenyl)alkanediamides from 4-nitroaniline were carried out. These compounds were subjected to cytotoxic evaluation against different tumoural cell lines. A QSAR analysis for the aminated series, introducing a QSAR descriptor (D(CL)) designed herein for groove binders, reveals that the activity in the K562 cell line is related to the charge, polarisability, volume and length of the molecules.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Interior, Ciudad Universitaria, Coyoacán, 04510 Mexico DF, Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Chacón-García
authors.forename: R
authors.initials: R
authors.lastname: Martínez
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D021281:Quantitative Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000577:Amides; D000814:Aniline Compounds