Acute and chronic social defeat suppresses humoral immunity of male Syrian hamsters (Mesocricetus auratus).
Stressors, both physical and psychological, can activate the hypothalamic-pituitary-adrenal (HPA) axis, leading to a wide range of physiological responses including increased glucocorticoid release and suppression of immune function. The majority of studies published to date have focused on the effects of physical stressors (e.g., cold exposure, electric shock) on immunity. The present study examined the role of a stressor, social defeat, on humoral immune function of Syrian hamsters (Mesocricetus auratus). Specifically, adult male Syrian hamsters experienced social defeat (i.e., exposure to a dominant animal in that animal's home cage) that was either acute (i.e., a single exposure) or chronic (i.e., daily exposures across 5 days). A control group of animals was placed in a resident's home cage without the resident animal present and did not experience defeat. After the last encounter, blood samples were drawn and animals were subsequently injected with keyhole limpet hemocyanin (KLH). Blood samples were again taken 5 and 10 days postimmunization and serum was analyzed to determine serum cortisol and anti-KLH immunoglobulin G (IgG) concentrations. Cortisol concentrations were elevated in both acutely and chronically defeated hamsters compared with control animals. In contrast, serum IgG concentrations were significantly reduced in both groups of defeated hamsters compared with control animals. Collectively, these results demonstrate that both acute social defeat and chronic social defeat lead to activation of the HPA axis and suppression of humoral immune function. These data suggest that social defeat is an important, ecologically relevant model with which to examine stress-induced immune suppression in rodents.
Jasnow
A M
AM
Department of Psychology, Georgia State University, Atlanta, GA 30303, USA.
Drazen
D L
DL
Huhman
K L
KL
Nelson
R J
RJ
Demas
G E
GE
D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation / Q000276:immunology* / Q000502:physiology; D002908:Chronic Disease; D003163:Competitive Behavior / Q000502:physiology*; D006224:Cricetinae; D004797:Enzyme-Linked Immunosorbent Assay; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008647:Mesocricetus; D010913:Pituitary-Adrenal System / Q000502:physiology; D011863:Radioimmunoassay; D013315:Stress, Psychological / Q000503:physiopathology / Q000523:psychology
D007074:Immunoglobulin G; D006854:Hydrocortisone