title: Axbrn-1: a maternal transcript encodes a POU transcription factor that is later expressed in the developing central nervous system of axolotl embryos.
abstract: Axbrn-1 encodes a class III POU protein with a POU-specific domain and a POU homeodomain that is most similar to RHS2 from rat. In embryos Axbrn-1 transcripts are maternally inherited and persist through cleavage. New transcripts accumulate beginning at the mid-blastula transition. In gastrulating embryos Axbrn-1 RNA is in the dorsal marginal zone and by neurula it is in the neural folds and neural plate. Later, it is specific to the developing brain and anterior spinal cord. Transcriptional activation at the mid-blastula transition indicates that Axbrn-1 is among the earliest genes to be expressed in axolotl embryos.
authors.affiliation: Department of Biological Science, Florida State University, Tallahassee, FL 32301, USA.
authors.forename: T
authors.initials: T
authors.lastname: Masi
authors.forename: A D
authors.initials: AD
authors.lastname: Johnson
mesh_terms: D000558:Ambystoma mexicanum / Q000196:embryology* / Q000235:genetics*; D000596:Amino Acids / Q000032:analysis; D029845:Amphibian Proteins / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D002490:Central Nervous System / Q000196:embryology* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry; D050809:POU Domain Factors; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*
chemical_list: D000596:Amino Acids; D029845:Amphibian Proteins; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; D050809:POU Domain Factors; C484088:Pou3f4 protein, rat; D012333:RNA, Messenger; D014157:Transcription Factors