title: Noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone derivatives. part I: synthesis and SAR studies for the inhibition of TNF-alpha production.
abstract: This study describes the synthesis and in vitro evaluation of noble 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone derivatives for the inhibition of TNF-alpha production. Among these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyll-3-methyl-1-isoindolinone (5) was the most potent in inhibitory activity of TNF-alpha production in LPS-stimulated RAW264.7 cells.
authors.affiliation: Institute of Biosciences & Biotechnology, Daewoong Pharm Co. Ltd., Yongin, Kyunggi-do 449-814, Korea. joonchem@daewoong.co.kr
authors.forename: J S
authors.initials: JS
authors.lastname: Park
authors.forename: K U
authors.initials: KU
authors.lastname: Baik
authors.forename: J Y
authors.initials: JY
authors.lastname: Cho
authors.forename: E S
authors.initials: ES
authors.lastname: Yoo
authors.forename: Y S
authors.initials: YS
authors.lastname: Byun
authors.forename: M H
authors.initials: MH
authors.lastname: Park
mesh_terms: D000818:Animals; D002460:Cell Line; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D007202:Indicators and Reagents; D007211:Indoles; D014409:Tumor Necrosis Factor-alpha