Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.
The anti-inflammatory activities of three flavonoids were investigated in rats using the Mizushima et al. model of acute and chronic inflammation. Intraperitoneal administration of rutin, quercetin (flavonols) and hesperidin (flavanone), given at daily doses equivalent to 80 mg/kg, inhibited both acute and chronic phases of this experimental model of inflammation. Rutin was the most active in the chronic phase.
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Departamento de Farmacia, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Argentina.
Rotelli
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Juarez
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Pelzer
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LE
D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D006569:Hesperidin / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D011794:Quercetin / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012431:Rutin / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D012431:Rutin; D011794:Quercetin; D006569:Hesperidin