title: Semisynthesis of Some 7-Deoxypaclitaxel Analogs from Taxine B.
abstract: Taxine B (3), isolated from the dried needles of Taxus baccata, was converted into six novel 7-deoxypaclitaxel analogs, 20, 21a,b, and 23-25, that have structural changes at C1, C2, and C4. A method for the introduction of the benzoyl function at C2, via a benzylidene acetal at C1-C2, will be revealed. All compounds showed very little or no measurable cytotoxic activity against some well-characterized human tumor cell lines, probably due to the nonacylated hydroxyl group at C4.
authors.affiliation: Department of Organic Chemistry, University of Nijmegen, NSR-Center, Toernooiveld, 6525 ED Nijmegen, The Netherlands.
authors.forename: Peter H. G.
authors.initials: PH
authors.lastname: Wiegerinck
authors.forename: Lizette
authors.initials: L
authors.lastname: Fluks
authors.forename: Jeannet B.
authors.initials: JB
authors.lastname: Hammink
authors.forename: Suzanne J. E.
authors.initials: SJ
authors.lastname: Mulders
authors.forename: Franciscus M. H.
authors.initials: FM
authors.lastname: de Groot
authors.forename: Hendrik L. M.
authors.initials: HL
authors.lastname: van Rozendaal
authors.forename: Hans W.
authors.initials: HW
authors.lastname: Scheeren