Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis.
The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours.
Westbury
J
J
School of Biological Sciences, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK.
Watkins
M
M
Ferguson-Smith
A C
AC
Smith
J
J
D000818:Animals; D000918:Antibody Specificity; D050761:Cyclin-Dependent Kinase Inhibitor p57; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D005314:Embryonic and Fetal Development; D004791:Enzyme Inhibitors; D005121:Extremities / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000196:embryology; D007668:Kidney / Q000196:embryology / Q000378:metabolism; D008168:Lung / Q000196:embryology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009024:Morphogenesis; D009141:Musculoskeletal System / Q000196:embryology / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D014018:Tissue Distribution
C493965:Cdkn1c protein, mouse; D050761:Cyclin-Dependent Kinase Inhibitor p57; D004791:Enzyme Inhibitors; D009687:Nuclear Proteins; D018844:Cyclin-Dependent Kinases