title: Capillary zone electrophoresis determination of perphenazine in pharmaceutical preparations and in human serum.
abstract: Perphenazine belongs to the group of phenothiazine-based neuroleptic drugs frequently used in the long-term treatment of psychotic disorders. In this work, a new capillary zone electrophoresis (CZE) method for the rapid determination of perphenazine (PPZ) in pharmaceutical preparations and human blood serum was developed. Using solid-phase extraction (SPE) as a preclean/purification and preconcentration step before CZE analysis, a detection limit of 3 ng/mL for the monitoring of PPZ in blood serum (for a signal-to-noise ratio of 3) was reached.
authors.affiliation: Department of Analytical Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Malecek
authors.forename: E
authors.initials: E
authors.lastname: Hadasová
authors.forename: J
authors.initials: J
authors.lastname: Havel
mesh_terms: D000097:Acetonitriles; D004586:Electrophoresis; D019075:Electrophoresis, Capillary; D005470:Fluorometry; D006801:Humans; D010546:Perphenazine / Q000032:analysis* / Q000097:blood / Q000302:isolation & purification; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012997:Solvents
chemical_list: D000097:Acetonitriles; D012997:Solvents; D010546:Perphenazine; C032159:acetonitrile