title: Pregnancy achieved following ICSI from a man with Klinefelter's syndrome and spinal cord injury.
abstract: Klinefelter's syndrome and spinal cord injury are major causes of male infertility. Intracytoplasmic sperm injection (ICSI) is a relatively new method of assisted reproduction. A testicular biopsy was obtained from a patient with the double complications of non-mosaic 47,XXY Klinefelter's syndrome and spinal cord damage, and motile spermatozoa were collected. ICSI was then performed. Of the four sperm-injected oocytes, three became fertilized and cleaved. Two embryos were implanted, resulting in a single pregnancy with visible evidence of a heartbeat appearing at 6 weeks gestation. The pregnancy is now entering its 20th week. To the best of our knowledge, this is the first case of a pregnancy resulting from the sperm of a patient with double complications.
authors.affiliation: Ladies Clinic Kyono, Furukawa, Miyagi, Japan. a1951414@coral.ocn.ne.jp
authors.forename: K
authors.initials: K
authors.lastname: Kyono
authors.forename: N
authors.initials: N
authors.lastname: Fukunaga
authors.forename: K
authors.initials: K
authors.lastname: Haigo
authors.forename: S
authors.initials: S
authors.lastname: Chiba
authors.forename: Y
authors.initials: Y
authors.lastname: Araki
mesh_terms: D000328:Adult; D001706:Biopsy; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000628:therapy*; D007713:Klinefelter Syndrome / Q000150:complications*; D008297:Male; D008596:Menotropins / Q000008:administration & dosage; D010062:Ovulation Induction; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa; D013119:Spinal Cord Injuries / Q000150:complications*; D013737:Testis / Q000473:pathology; D020858:Tissue and Organ Harvesting
chemical_list: D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins