title: Recent advances in chemical approaches to the study of biological systems.
abstract: A number of novel chemical methods for studying biological systems have recently been developed that provide a means of addressing biological questions not easily studied with other techniques. In this review, examples that highlight the development and use of such chemical approaches are discussed. Specifically, strategies for modulating protein activity or protein-protein interactions using small molecules are presented. In addition, methods for generating and utilizing novel biomolecules (proteins, oligonucleotides, oligosaccharides, and second messengers) are examined.
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143-0450, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Shogren-Knaak
authors.forename: P J
authors.initials: PJ
authors.lastname: Alaimo
authors.forename: K M
authors.initials: KM
authors.lastname: Shokat
mesh_terms: D000818:Animals; D020650:Combinatorial Chemistry Techniques; D005544:Forecasting; D006801:Humans; D008958:Models, Molecular; D008967:Molecular Biology / Q000379:methods*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D019151:Peptide Library; D025941:Protein Interaction Mapping / Q000379:methods*; D047428:Protein Kinase Inhibitors; D011506:Proteins / Q000138:chemical synthesis* / Q000235:genetics / Q000378:metabolism; D015290:Second Messenger Systems
chemical_list: D009841:Oligonucleotides; D009844:Oligosaccharides; D019151:Peptide Library; D047428:Protein Kinase Inhibitors; D011506:Proteins