title: Enantiospecific Synthesis of Trisubstituted Butyrolactone Natural Products and Their Analogs.
abstract: A general methodology for the synthesis of highly substituted butyrolactones in enantiomerically pure form has been developed. The application of this process in a highly efficient synthesis of lactone natural products blastmycinone (1), NFX-2 (2), antimycinone (3), and NFX-4 (4) and two lipid metabolites (5, 6) are described. Additionally, the total synthesis of 5-epi-blastmycinone (22), 5-epi-NFX-2 (21b), 5-epi-NFX-4 (21c), and lipid metabolite analogs (19, 20) are also described. The overall yields for the target molecules are the highest reported so far in the literature.
authors.affiliation: Department of Chemistry, North Dakota State University, Fargo, North Dakota 58105-5516.
authors.forename: Mukund P.
authors.initials: MP
authors.lastname: Sibi
authors.forename: Jianliang
authors.initials: J
authors.lastname: Lu
authors.forename: Chelsy L.
authors.initials: CL
authors.lastname: Talbacka