title: [A case of adult Wilms' tumor].
abstract: Wilms' tumor is very rarely found in adults and there are no established treatment guidelines for such tumors in adults. A 56-year-old woman was referred to our hospital for further examination of macroscopic hematuria. Computed tomography scan revealed a large right renal mass with enlarged lymph nodes. Angiography showed a hypovascular tumor. She underwent right nephrectomy and resection of lymph node metastasis with a diagnosis of malignant renal tumor. Histopathological examination revealed nephroblastoma with lymph node metastasis. The disease was classified as stage III according to the National Wilms' Tumor Study classification. The patient received adjuvant chemotherapy consisting of ifosfamide, cisplatin, and etoposide. This protocol was selected because of the published poor results with the standard Wilms' tumor chemotherapeutic agents when used in adults. She remained without tumor recurrence as of six months after surgery. Development of better therapeutic approaches to adult Wilms' tumor is awaited.
authors.affiliation: Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases.
authors.forename: Y
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: S
authors.initials: S
authors.lastname: Saiki
authors.forename: T
authors.initials: T
authors.lastname: Hanafusa
authors.forename: N
authors.initials: N
authors.lastname: Meguro
authors.forename: O
authors.initials: O
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Kinouchi
authors.forename: M
authors.initials: M
authors.lastname: Kuroda
authors.forename: M
authors.initials: M
authors.lastname: Usami
authors.forename: T
authors.initials: T
authors.lastname: Kotake
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D009392:Nephrectomy; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*
chemical_list: D005047:Etoposide; D002945:Cisplatin; D007069:Ifosfamide