Comparative study of modulatory effects of Semax and primary proline-containing peptides on hemostatic reactions.
Intranasal administration of Semax, peptide Pro-Gly-Pro, and a mixture of peptides Pro-Gly+Gly-Pro to rats for 5 days enhanced anticoagulant and fibrinolytic potential of the plasma (total fibrinolytic activity and plasmin and plasminogen activator activities) and decreased antiplasmin concentration. Semax and Pro-Gly-Pro decreased the weight of thrombi during experimental thrombosis.
Cherkasova
K A
KA
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow. chk99@mail.ru
Lyapina
L A
LA
Ashmarin
I P
IP
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004151:Dipeptides / Q000494:pharmacology; D005341:Fibrinolysin / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006801:Humans; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D051381:Rats
D000925:Anticoagulants; D004151:Dipeptides; D005343:Fibrinolytic Agents; D009842:Oligopeptides; D010446:Peptide Fragments; C113164:prolyl-glycyl-proline; C057749:prolylglycine; C015248:glycylproline; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D011392:Proline; D005341:Fibrinolysin