title: Total Synthesis and Absolute Configuration of (-)-Anthoplalone.
abstract: We report the total synthesis of the cytotoxic agent (-)-anthoplalone and the determination of its absolute stereochemistry. The cyclopropane moiety was prepared using a nonracemic bicyclic chloroallyl phosphonamide anion addition to tert-butyl 3,3-dimethyl acrylate. Several pathways were studied to secure the E-trisubstituted olefin of the left part of the molecule.
authors.affiliation: Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, Québec H3C 3J7 Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Hanessian
authors.forename: Louis-David
authors.initials: LD
authors.lastname: Cantin
authors.forename: Daniele
authors.initials: D
authors.lastname: Andreotti