Dosing time-dependent effect of trandolapril on the prevention of cardiac hypertrophy in rats with aortic banding.
Trandolapril was given to male Wistar rats with aortic banding at 10 AM or 10 PM for 6 weeks to examine the influence of dosing time on the development of left ventricular mass (LVM). Aortic banding increased the LVM compared with the sham-operated animals (P<0.01). Trandolapril (1 mg/kg) at 10 AM reduced LVM (1.74+/-0.04 [S.E.M.] mg/g) more than the dosing at 10 PM (1.92+/-0.04 mg/g, P<0.05), suggesting that trandolapril has a dosing time-dependent effect in the prevention of cardiac hypertrophy in rats with aortic banding.
Sugimoto
K
K
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan. ksugi@jichi.ac.jp
Ohmori
M
M
Kawaguchi
A
A
Tsuruoka
S
S
Fujimura
A
A
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000601:surgery; D006332:Cardiomegaly / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D017379:Hypertrophy, Left Ventricular / Q000517:prevention & control; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; C052035:trandolapril