Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster.
We studied the effects of Epithalon (Ala-Glu-Asp-Gly) and Vilon (Lys-Glu) on free radical processes in highly inbred HA(+)line of Drosophila melanogaster. Vilon inhibited generation of reactive oxygen species in mitochondria, but stimulated this process in the cytosol. We found sex- and age-related differences in the generation of reactive oxygen species and cytosol antioxidant activity.
Khavinson
V K
VK
St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences. vvm@medport.ru
Myl'nikov
S V
SV
Oparina
T I
TI
Arutyunyan
A V
AV
D000375:Aging / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002458:Cell Fractionation; D004151:Dipeptides / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D007814:Larva / Q000502:physiology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000975:Antioxidants; D004151:Dipeptides; D009842:Oligopeptides; D017382:Reactive Oxygen Species; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine