title: Use of marginal organs from non-heart-beating cadaveric kidney donors.
abstract: BACKGROUND
  The severe shortage of cadaver donor kidneys for transplantation has prompted many centers to utilize older donor kidneys, which have been associated with lower graft survival rates. The aim of the present study was to examine the availability and feasibility of considering kidneys from donors over the age of 60.
  
  
  METHODS
  We studied 252 cadaveric renal transplant recipients (156 males, 96 females) who received kidneys from uncontrolled non-heart-beating donors between 1987 and 1997. We performed in situ cooling with especially designed double-balloon catheters to minimize warm ischemic kidney damage. Recipients were classified according to donor age (<age 60 and >age 60), and we examined graft survival rates. All patients were followed for a minimum of 1 year after transplantation.
  
  
  RESULTS
  Graft survival rates for recipients of kidneys from the older donor group at 1, 5, and 10 years after transplantation were 77%, 37%, and 30%, respectively. Corresponding values for the younger donor kidney recipients were 87%, 64%, and 47%, respectively (P=0.0011). Improved survival rates were noted when older kidneys were used for lighter weight recipients (<54 kg). No other significant factors impacted on older donor graft survival rates.
  
  
  CONCLUSIONS
  Older donor kidneys are associated with poorer graft survival rates. However, kidney transplants from older donors can be quite effective in lighter weight recipients (<54 kg).
authors.affiliation: Department of Urology, Nagoya University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mizutani
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
authors.forename: T
authors.initials: T
authors.lastname: Kinukawa
authors.forename: R
authors.initials: R
authors.lastname: Hattori
authors.forename: N
authors.initials: N
authors.lastname: Nishiyama
authors.forename: O
authors.initials: O
authors.lastname: Kamihila
authors.forename: S
authors.initials: S
authors.lastname: Ohshima
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002102:Cadaver; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors