title: Retinal blood flow and systemic blood pressure in healthy young subjects.
abstract: BACKGROUND
  The aim of the present study was to investigate the association between systemic blood pressure and retinal blood flow in healthy young subjects.
  
  
  METHODS
  Three independent study cohorts were included. A cross-sectional study was performed in 420 young male subjects with systolic blood pressure < 160 mmHg and diastolic blood pressure <100 mmHg. Retinal white blood cell flux (n=210) and blood velocity in the central retinal artery (n=210) were measured. In addition, a longitudinal study was performed in 40 young male subjects in whom retinal and systemic haemodynamic parameters were measured thrice within 6 weeks. Retinal white blood cell flux was measured with the blue-field entoptic technique. Blood flow velocity in the central retinal artery was measured by means of colour Doppler imaging.
  
  
  RESULTS
  Retinal white blood cell flux (r=0.262; P<0.001) and mean flow velocity in the central retinal artery (r=0.174, P=0.010) were significantly associated with mean arterial pressure in the cross-sectional study. In the longitudinal study retinal white blood cell flux and mean flow velocity in the central retinal artery were also correlated with systemic blood pressure.
  
  
  CONCLUSIONS
  Our data indicate a slight but significant increase in retinal blood flow with blood pressure. Whether this is of clinical relevance in eye diseases with altered retinal perfusion, such as diabetic retinopathy, remains to be established.
authors.affiliation: Department of Clinical Pharmacology, Vienna, Austria
authors.forename: G
authors.initials: G
authors.lastname: Fuchsjäger-Mayrl
authors.forename: K
authors.initials: K
authors.lastname: Polak
authors.forename: A
authors.initials: A
authors.lastname: Luksch
authors.forename: E
authors.initials: E
authors.lastname: Polska
authors.forename: G T
authors.initials: GT
authors.lastname: Dorner
authors.forename: G
authors.initials: G
authors.lastname: Rainer
authors.forename: H G
authors.initials: HG
authors.lastname: Eichler
authors.forename: L
authors.initials: L
authors.lastname: Schmetterer
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006801:Humans; D017078:Laser-Doppler Flowmetry; D007962:Leukocytes / Q000502:physiology; D008297:Male; D012039:Regional Blood Flow / Q000502:physiology; D012161:Retinal Artery / Q000502:physiology*; D018615:Ultrasonography, Doppler, Color