[Counteraction effect of intermittent -Gx on changes of responsiveness of basilar artery in tail-suspended rats].
OBJECTIVE
To investigate counteracting effects of intermittent -Gx exposure on changes of responsiveness of basilar artery in tall-suspended rats.


METHODS
Rats tail-suspended for 3 wk were daily subjected to 1 h 1.5 G or 2.6 G centrifugation, simulating -Gx exposure of various G values. Responses of perfused isolated basilar arterial rings to KCl was examined.


RESULTS
Maximal isometric contractile response to KCl were significantly enhanced in arterial rings isolated from 3 wk tail-suspended rats as compared with that from simultaneous control rats (P < 0. 05). However, maximal isometric contractile responses to KCl of arterial rings isolated from 3 wk tail-suspended plus daily -Gx exposure rats were no difference as compared with that from simultaneous control rats, and were significantly decreased (P < 0.05) as compared with that from 3 wk tail-suspended rats.


CONCLUSIONS
Daily intermittent -Gx exposure as a countermeasure to prevent the effects of simulated weightless on changes in responsiveness of basilar artery from tail-suspended rats was valid.
Zhang
L N
LN
Department of Aerospace Physiology, Xi'an 710032, China.
Cheng
J H
JH
Ni
H Y
HY
Ma
J
J
Zhang
L F
LF
Wu
Y H
YH
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects / Q000502:physiology*; D002498:Centrifugation; D019417:Hindlimb Suspension; D018471:Hypergravity; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D018544:Weightlessness Countermeasures; D018474:Weightlessness Simulation
D011189:Potassium Chloride