P(RNCH(2)CH(2))(3)N-Catalyzed Synthesis of beta-Hydroxy Nitriles.
We herein report the successful synthesis of beta-hydroxy nitriles in very good to excellent yields from aldehydes and ketones in a simple reaction that is promoted by strong nonionic bases of the title type. The reaction occurs in the presence of magnesium salts which activate the carbonyl group and stabilizes the enolate thus produced.
Kisanga
Philip
P
Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111.
McLeod
Dale
D
D'Sa
Bosco
B
Verkade
John
J