title: A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain.
abstract: We have identified a novel 14-exon human lysyl oxidase-like gene, LOXL4, on chromosome 10q24. The cDNA and derived amino acid sequence of LOXL4 demonstrates a conserved C-terminal region including the characteristic copper-binding site, lysyl and tyrosyl residues and a cytokine receptor-like domain. One of the four N-terminal SRCR domains contains a 13 amino acid insertion encoded by a short exon not present within the closely homologous LOXL2 and LOXL3 genes. The 3.5-kb LOXL4 mRNA is present in pancreas and testis and at lower levels in several other tissues. Fibroblasts, smooth muscle and osteosarcoma (HOS) cells express LOXL4. No expression was detected in HCT-116 and DLD-1 colon, MCF-7 breast and DU-145 prostate cancer cell lines.
authors.affiliation: Pacific Biomedical Research Center, University of Hawaii, 1960 East West Rd., Honolulu, HI 96822, USA.
authors.forename: L
authors.initials: L
authors.lastname: Asuncion
authors.forename: B
authors.initials: B
authors.lastname: Fogelgren
authors.forename: K S
authors.initials: KS
authors.lastname: Fong
authors.forename: S F
authors.initials: SF
authors.lastname: Fong
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Csiszar
mesh_terms: D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D000594:Amino Acid Oxidoreductases / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002879:Chromosomes, Human, Pair 10; D003545:Cysteine / Q000235:genetics / Q000378:metabolism*; D018076:DNA, Complementary; D005091:Exons; D006801:Humans; D008297:Male; D008565:Membrane Proteins; D051379:Mice; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017434:Protein Structure, Tertiary; D008249:Protein-Lysine 6-Oxidase; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D014018:Tissue Distribution
chemical_list: D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D018076:DNA, Complementary; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D000594:Amino Acid Oxidoreductases; C445682:LOXL4 protein, human; D008249:Protein-Lysine 6-Oxidase; D003545:Cysteine