title: Characterization of NO and cytokine release by transplantable melanoma cell lines in relationship to their differentiation.
abstract: Changes in the secretory activity of two transplantable melanoma lines (differing in many biological features) as regards nitric oxide (NO) release and interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and oncostatin M (OSM) secretion were the subject of the present study. The results obtained show that a spontaneous alteration of the hamster native melanoma line into an amelanotic one is accompanied by a global change of the secretory activity, but there was not a distinct correlation between the endogenous cytokine secretion and NO secretion by cells of both melanoma lines.
authors.affiliation: Department of Embryology, Medical University of Gdańsk, Poland. cecylia@amedec.amg.gda.pl
authors.forename: K
authors.initials: K
authors.lastname: Kozłowska
authors.forename: M
authors.initials: M
authors.lastname: Zarzeczna
authors.forename: M
authors.initials: M
authors.lastname: Cichorek
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006224:Cricetinae; D016207:Cytokines / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis; D008297:Male; D008546:Melanoma, Experimental / Q000378:metabolism* / Q000473:pathology; D008647:Mesocricetus; D009569:Nitric Oxide / Q000096:biosynthesis*; D053683:Oncostatin M; D010455:Peptides / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D010455:Peptides; D014409:Tumor Necrosis Factor-alpha; D053683:Oncostatin M; D009569:Nitric Oxide