title: Synthesis and fungicidal activity of substituted pyrazolo[5,4-b] pyridine/pyrid-6-ones and pyrazolo[5,4-d]thiazines.
abstract: 6-amino-1-Aryloxyaceto-4-aryl-5-cyano-4,5-dihydro-3-methy-l-1H-pyrazolo [5,4-b] pyridines (3)/pyrid-6-ones (4) and 1-Aryloxyaceto-6-amino-4-aryl-3-methyl-4H-pyrazolo[5,4-d]-1,3-thiazines (5), have been prepared by Michael addition between a,b-unsaturated ketones (2) and malononitrile/ethyl cyanoacetate and thiourea respectively. The antifungal activity against Aspergillus niger, Helminthosporium oryzae and Pyricularia oryzae have been evaluated and compared with commercial fungicide Carbendazim tested under similar conditions.
authors.affiliation: Agro-Chemical Research Laboratory, Chemistry Department, University Gorakhpur, India.
authors.forename: M G
authors.initials: MG
authors.lastname: Nizamuddin
authors.forename: K S
authors.initials: KS
authors.lastname: Manoj
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D011720:Pyrazoles; D011725:Pyridines; D013843:Thiazines