title: New Efficient Nickel-Catalyzed Cross-Coupling Reaction between Two Csp(3) Centers.
abstract: The presence of a remote unsaturation (double bond, carbonyl group, cyano group) in an alkyl halide facilitates its cross-coupling reaction with various diorganozincs in the presence of Ni(acac)(2) (7.5-10 mol % in THF/NMP mixtures). These results were used to develop a new general cross-coupling reaction between functionalized diorganozincs and alkyl iodides using m- or p-trifluoromethylstyrene as a reaction promotor and Ni(acac)(2) as a catalyst (7.5-10 mol %; -35 degrees C, 5-10 h) leading to a broad range of polyfunctional cross-coupling products.
authors.affiliation: Fachbereich Chemie der Philipps-Universität Marburg, Hans-Meerwein-Strasse, D-35043 Marburg, Germany, and Institut für Organische Chemie der Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, D-81377 München, Germany.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Giovannini
authors.forename: Thomas
authors.initials: T
authors.lastname: Stüdemann
authors.forename: Arokiasamy
authors.initials: A
authors.lastname: Devasagayaraj
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Dussin
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel