[Inflammatory cytokines (IL-4, IL-5 and IL-13)].
The polarized Th2 cells play an important role in the pathogenesis of atopic asthma as well as in the induction of airway inflammation. Th2 cytokines, such as IL-4, IL-5 and IL-13, are pivotal in regulating the allergic phenotype, the IgE response or the inflammatory cell-mediated function. Selective inhibition of Th2 cytokines by pharmacologic agents, including anti-cytokine blocking antibody, cytokine mutant and soluble cytokine receptor, will contribute to asthma therapy. Strategies based on blocking key signaling cytokines are also discussed.
Maeda
S
S
Clinical Research Center, National Sagamihara Hospital.
Yanagihara
Y
Y
D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy / Q000276:immunology; D007073:Immunoglobulin E; D018793:Interleukin-13 / Q000037:antagonists & inhibitors / Q000502:physiology; D053661:Interleukin-13 Receptor alpha1 Subunit; D015847:Interleukin-4 / Q000037:antagonists & inhibitors / Q000502:physiology; D015848:Interleukin-5 / Q000037:antagonists & inhibitors / Q000502:physiology; D018123:Receptors, Interleukin / Q000037:antagonists & inhibitors / Q000502:physiology; D053660:Receptors, Interleukin-13; D019948:Receptors, Interleukin-4 / Q000037:antagonists & inhibitors / Q000502:physiology; D053649:Receptors, Interleukin-5; D015398:Signal Transduction / Q000187:drug effects; D018418:Th2 Cells / Q000276:immunology
D018927:Anti-Asthmatic Agents; C508181:IL13RA1 protein, human; D018793:Interleukin-13; D053661:Interleukin-13 Receptor alpha1 Subunit; D015848:Interleukin-5; D018123:Receptors, Interleukin; D053660:Receptors, Interleukin-13; D019948:Receptors, Interleukin-4; D053649:Receptors, Interleukin-5; D015847:Interleukin-4; D007073:Immunoglobulin E