title: First Total Synthesis of an Exceptionally Potent Antitumor Saponin, OSW-1.
abstract: OSW-1 (1), an acylated disaccharide cholestane saponin from Ornithogalum saudersiae with exceptionally potent antitumor activity, was first synthesized from commercially available dehydroisoandrosterone, L-arabinose, and D-xylose in total 27 steps with the longest linear sequence of 14 steps and in 6% yield.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.
authors.forename: Shaojiang
authors.initials: S
authors.lastname: Deng
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
authors.forename: Yun
authors.initials: Y
authors.lastname: Lou
authors.forename: Yongzheng
authors.initials: Y
authors.lastname: Hui