Role of muscular exercise in amyotrophic lateral sclerosis.
The general, systemic, and specific neuromuscular adaptation to physical exercise and training in healthy individuals is reviewed with application to individuals with neuromuscular disease in general and ALS in particular. A pilot study utilizing patients with ALS suggests the cardiopulmonary response to acute exercise is similar to normal individuals. However, a case study of a training response suggests the success of neuromuscular adaptation will be dependent upon the degree of motor neuron involvement.
Sanjak
M
M
Department of Neurology, University of Wisconsin Medical School, ALS Clinical Research Center, University of Wisconsin Hospital and Clinics, Madison 53792, USA.
Reddan
W
W
Brooks
B R
BR
D000328:Adult; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000503:physiopathology / Q000534:rehabilitation*; D009046:Motor Neurons / Q000502:physiology; D009121:Muscle Denervation / Q000534:rehabilitation; D010101:Oxygen Consumption / Q000502:physiology; D026741:Physical Therapy Modalities