Defining severe community-acquired pneumonia.
Based on the recognition of the main pathophysiologic features of pneumonia and currently available data on prognosis and clinical severity assessment, key points for a definition of severe pneumonia are as follows: 1. Independent predictors of pneumonia severity are factors reflecting acute respiratory failure and severe sepsis or septic shock. 2. In view of the dependence of the development of acute respiratory failure on pulmonary comorbidities, radiographic extension may prove to be an additional independent predictor of severe respiratory compromise. 3. Vital sign abnormalities other than acute respiratory failure and severe hypotension may be independent predictors of severity, particularly in patients presenting in early and asymptomatic stages of severe sepsis. 4. Several pathogens have been shown to have adverse prognostic potential. Because the cause is unknown at the initial evaluation, however, pathogens cannot form part of the criteria for the initial severity assessment. 5. Because pneumonia is a dynamic process, any assessment of severity takes place at an arbitrary point of disease evolution. It would be desirable to define a set of parameters reflecting initial severity as well as a state of increased risk for early deterioration toward severe pneumonia. 6. Severity stratification within the population of patients with severe pneumonia may open the prospect of identifying patients who may have the greatest benefit from intensive care.
Neuhaus
T
T
Department of Critical Care Medicine, Medizinische Universitäts-Poliklinik Bonn, Germany.
Ewig
S
S
D000367:Age Factors; D017714:Community-Acquired Infections / Q000145:classification* / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology / Q000503:physiopathology; D015897:Comorbidity; D020022:Genetic Predisposition to Disease; D006801:Humans; D011014:Pneumonia / Q000145:classification* / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012131:Respiratory Insufficiency / Q000382:microbiology; D018570:Risk Assessment; D012307:Risk Factors; D018805:Sepsis / Q000382:microbiology; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000382:microbiology