title: Directional bonding in compacted microcrystalline cellulose.
abstract: The mechanical properties of compacts of microcrystalline cellulose (MCC) and silicified microcrystalline cellulose (SMCC) were evaluated by tensile testing, diametric compression testing, and compression testing. For tensile and compression testing, cubic specimens were carefully machined from MCC and SMCC compacts, and the tensile and compression strengths were evaluated both normal and parallel to the compaction direction. The cubic tensile strengths were compared to values obtained from the diametric compression test. The results obtained using the diametric compression test suggested compacts of SMCC exhibit greater strength than those of MCC. In addition, the cubes machined from compacts of MCC and SMCC exhibited directional strength; the direction normal to the compaction direction display ed the greater tensile strength, and the parallel direction had greater compression strength. The diametric compression test afforded strength values with reduced spread compared to the values collected from the cubic tensile test, suggesting that the errors involved in collecting diametric compression test data of compacts are less than those for the cubic tensile test. Analysis of the cubes using X-ray diffraction (XRD) suggested that they display directional structural anisotropy, with the direction normal to the compaction direction being more crystalline than the parallel direction. However, it is not clear whether the difference in the directional strength is solely a consequence of the increased crystallinity or a culmination of crystallographic and mechanical keying effects.
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, UK. prssje@bath.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Edge
authors.forename: D F
authors.initials: DF
authors.lastname: Steele
authors.forename: M J
authors.initials: MJ
authors.lastname: Tobyn
authors.forename: J N
authors.initials: JN
authors.lastname: Staniforth
authors.forename: A
authors.initials: A
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D002482:Cellulose / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011312:Pressure; D013718:Tensile Strength; D014961:X-Ray Diffraction
chemical_list: D005079:Excipients; D002482:Cellulose; C109691:microcrystalline cellulose