title: Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp.
abstract: Two novel, highly potent, cytotoxic macrolides, salicylihalamides A (1) and B (2), were isolated from the sponge Haliclona sp. This new macrolide class incorporates salicylic acid, a 12-membered lactone ring, and an enamide side chain. COMPARE pattern-recognition analyses of the NCI 60-cell mean graph screening profiles of 1 did not reveal any significant correlations to the profiles of known antitumor compounds in the NCI's "standard agent database", thus supporting the conclusion that the salicylihalamides represent a potentially important new class for antitumor lead optimization and in vivo investigations.
authors.affiliation: Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment, Diagnosis, and Centers, National Cancer Institute-FCRDC, Building 1052, Room 121, Frederick, Maryland 21702-1201.
authors.forename: Karen L.
authors.initials: KL
authors.lastname: Erickson
authors.forename: John A.
authors.initials: JA
authors.lastname: Beutler
authors.forename: John H.
authors.initials: JH
authors.lastname: Cardellina II
authors.forename: Michael R.
authors.initials: MR
authors.lastname: Boyd