The association between Viadent use and oral leukoplakia.
Recently, leukoplakia of the maxillary vestibule was described in patients with no traditional risk factors but who had used Viadent products. We designed a case-control study to evaluate the hypothesis that Viadent users were more likely to have lesions. One hundred and forty-eight cases and controls were identified through the Section of Oral and Maxillofacial Pathology. Cases and controls were administered a questionnaire about Viadent use and other known risks. Results of crude, stratified, and logistic regression analyses showed that use of Viadent products was a risk indicator for leukoplakia (adjusted OR = 9.7, 95% CI = 4.7-21.6), with a strong dose-response relation.
Mascarenhas
A K
AK
Section of Health Service Research, College of Dentistry, The Ohio State University, Columbus 43218-2357, USA.
Allen
C M
CM
Loudon
J
J
D000428:Alcohol Drinking / Q000009:adverse effects; D000470:Alkaloids / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D053119:Benzophenanthridines; D016022:Case-Control Studies; D017266:Dental Prosthesis; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007546:Isoquinolines; D007971:Leukoplakia / Q000139:chemically induced* / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D016017:Odds Ratio; D009820:Ohio / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D000470:Alkaloids; D000890:Anti-Infective Agents; D053119:Benzophenanthridines; D007546:Isoquinolines; C005705:sanguinarine