title: Of snakes, snails, and surrogates.
abstract: The high-resolution structure of a synthetic 13-residue peptide in a tight complex with alpha-bungarotoxin conforms to the beta hairpin structure of a closely related segment in the ACh binding protein and reveals how the ACh binding protein and the homologous nicotinic ACh receptors bind alpha-bungarotoxin at their ACh binding sites.
authors.affiliation: Center for Molecular Recognition, Columbia University, 630 West 168th Street, New York, NY 10032, USA.
authors.forename: A
authors.initials: A
authors.lastname: Karlin
mesh_terms: D000818:Animals; D001665:Binding Sites; D002038:Bungarotoxins / Q000378:metabolism*; D004546:Elapid Venoms / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D011950:Receptors, Cholinergic / Q000737:chemistry* / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000378:metabolism; D012908:Snails / Q000378:metabolism*
chemical_list: D002038:Bungarotoxins; D004546:Elapid Venoms; D010446:Peptide Fragments; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic