title: Solid-Phase Synthesis and Photophysical Properties of DNA Labeled at the Nucleobase with Ru(bpy)(2)(4-m-4'-pa-bpy)(2+).
abstract: A facile procedure for incorporating a Ru(diimine)(3)(2+) complex at the nucleobase in an oligonucleotide is reported that combines the advantages of Pd(0) cross-coupling and solid-phase DNA chemistries. These ruthenium-modified oligonucleotides form stable duplexes, and the favorable photophysical properties associated with the Ru(diimine)(3)(2+) complex are retained after site-specific covalent attachment.
authors.affiliation: Paul M. Gross Chemical Laboratory, Department of Chemistry, Duke University, Durham, North Carolina 27708.
authors.forename: Shoeb I.
authors.initials: SI
authors.lastname: Khan
authors.forename: Amy E.
authors.initials: AE
authors.lastname: Beilstein
authors.forename: Mark T.
authors.initials: MT
authors.lastname: Tierney
authors.forename: Milan
authors.initials: M
authors.lastname: Sykora
authors.forename: Mark W.
authors.initials: MW
authors.lastname: Grinstaff