Propriospinal myoclonus at the sleep-wake transition: a new type of parasomnia.
OBJECTIVE
To describe the clinical, neurophysiological, and polysomnographic characteristics of propriospinal myoclonus (PSM) at the sleep-wake transition.


METHODS
Patients referred for insomnia due to myoclonic activity arising during relaxed wakefulness preceding sleep, or complaining of muscular jerks also during intrasleep wakefulness and upon awakening in the morning were considered.


METHODS
All patients underwent EEG-EMG recordings during wakefulness and night sleep. Back-averaging of the EEG activity preceding the jerks was performed. Somatosensory evoked potentials (SEPs), transcranial magnetic stimulation (TMS) and spinal and cranial MRI were also done.


METHODS
Four patients were studied all affected with involuntary jerks arising when falling asleep, and one with jerks also during sleep and upon awakening in the morning.


METHODS
N/A.


RESULTS
Polysomnographic investigations revealed jerks arising during the sleep-wake transition period. Myoclonic activity was neurophysiologically documented to be of the propriospinal type. SEPs, TMS and MRI were normal


CONCLUSIONS
PSM may have a peculiar relationship with the state of vigilance and represent a sleep-wake transition disorder. In this regard we consider PSM a new type of parasomnia.
Vetrugno
R
R
Institute of Clinical Neurology, University of Bologna, Italy. elugares@neuro.unibo.it
Provini
F
F
Meletti
S
S
Plazzi
G
G
Liguori
R
R
Cortelli
P
P
Lugaresi
E
E
Montagna
P
P
D000328:Adult; D001921:Brain / Q000033:anatomy & histology; D003937:Diagnosis, Differential; D055590:Electromagnetic Phenomena / Q000295:instrumentation; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation; D009207:Myoclonus / Q000453:epidemiology* / Q000503:physiopathology*; D020447:Parasomnias / Q000175:diagnosis; D017286:Polysomnography / Q000295:instrumentation; D020922:Sleep-Wake Transition Disorders / Q000453:epidemiology*; D013127:Spinal Nerves / Q000033:anatomy & histology / Q000503:physiopathology*; D014851:Wakefulness / Q000502:physiology