Unexpected absence of correlation between the genetic mechanisms regulating beta-carboline-induced seizures and anxiety manifested in an elevated plus-maze test.
Among the ligands of the benzodiazepine site, one can mention the benzodiazepines as agonists and some beta-carbolines (e.g. methyl-beta-carboline-3-carboxylate, abbreviated hereafter beta-CCM) as inverse agonists. Most benzodiazepines and beta-carbolines act on processes involved in memory, anxiety, and convulsions with opposite physiological effects. Since these molecules have influences on both anxiety and convulsions, we predicted that there would exist a genetic correlation between anxiety evaluated in an elevated plus-maze and susceptibility to beta-CCM-induced seizures. Using inbred strains of mice, the genetic correlation was estimated with the Hegmann and Possidente model. An absence of genetic correlation was found, showing that the mechanisms responsible for basal anxiety measured with the elevated plus-maze test and those leading to susceptibility to beta-CCM-induced seizures do not share the same genetic pathways.
Rinaldi
D
D
CHR Orléans, 1 rue de la porte Madeleine, 45000 Orléans, France. rinaldi@cnrs-orleans.fr
Larrigaldie
V
V
Chapouthier
G
G
Martin
B
B
D000818:Animals; D001007:Anxiety / Q000235:genetics*; D001143:Arousal / Q000235:genetics*; D002243:Carbolines / Q000494:pharmacology*; D003292:Convulsants; D004827:Epilepsy / Q000139:chemically induced / Q000235:genetics*; D005260:Female; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D011963:Receptors, GABA-A / Q000235:genetics*; D012931:Social Environment; D013045:Species Specificity
D002243:Carbolines; D003292:Convulsants; D011963:Receptors, GABA-A; C036150:beta-carboline-3-carboxylic acid methyl ester