Cytoskeleton: Microtubules get the signal.
Investigations of how the cytoskeleton is controlled by Rho GTPase signaling have focused largely on the remodeling of actin. Recent work in fibroblasts shows that microtubules are also subject to regulation by the Rho pathway, and that the signals acting on actin and microtubules can be teased apart.
Hollenbeck
P
P
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA. phollenb@purdue.edu
D000199:Actins / Q000378:metabolism*; D000818:Animals; D016764:Cell Polarity / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D051379:Mice; D008870:Microtubules / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D000199:Actins; D020741:rho GTP-Binding Proteins