title: Amyloid beta peptide as a vaccine for Alzheimer's disease involves receptor-mediated transport at the blood-brain barrier.
abstract: Much research is now focused on a potential vaccine for Alzheimer's disease (AD). Current studies involve administering the amyloid beta peptide (Abeta) in Freund's complete adjuvant, which cannot be used in humans. Our studies show that the immune complex of Abeta is taken up by a receptor-mediated process at the blood-brain barrier (BBB). The success of immunization for AD, therefore, may be critically dependent on circulating Abeta levels which are lower in AD patients compared to AD transgenic mice. Moreover, we have found that modifying the antibody with polyamine increases its BBB permeability and may provide a better approach to passive immunization for Alzheimer's disease.
authors.affiliation: Molecular Neurobiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Poduslo
authors.forename: G L
authors.initials: GL
authors.lastname: Curran
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology / Q000517:prevention & control*; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000276:immunology / Q000493:pharmacokinetics*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology / Q000493:pharmacokinetics; D000936:Antigen-Antibody Complex / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000276:immunology; D001921:Brain / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D002352:Carrier Proteins / Q000187:drug effects* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007114:Immunization / Q000379:methods*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D051379:Mice; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology / Q000493:pharmacokinetics*; D011073:Polyamines / Q000737:chemistry / Q000493:pharmacokinetics; D018000:Receptors, Peptide / Q000187:drug effects* / Q000276:immunology; D014612:Vaccines / Q000138:chemical synthesis / Q000493:pharmacokinetics*
chemical_list: D016229:Amyloid beta-Peptides; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D002352:Carrier Proteins; D007457:Iodine Radioisotopes; D010446:Peptide Fragments; D011073:Polyamines; D018000:Receptors, Peptide; D014612:Vaccines; C075222:amyloid beta-protein (1-42)