Solid variant of papillary renal cell carcinoma.
Solid variant of papillary renal cell carcinoma is a newly recognized renal epithelial neoplasm. We encounter a case of a 36-year-old male patient with a solitary right renal tumor. The tumor is composed of solid sheets of small uniform cell with intervening micronodules, resembling the glomeruloid bodies in a metanephric adenoma. Abortive papillae rather than typical papillary formations are found in the micronodules. Furthermore, the cells in these micronodules demonstrate more cellular atypia with abundant eosinophilic cytoplasm comparing to the intervening cells. Both types of neoplastic cells are immunoreactive for epithelial membrane antigen, cytokeratins 7 and 17, but not vimentin and 34 beta E12. The features of the tumor are consistent with solid variant of papillary renal cell carcinoma. Solid variant of papillary renal cell carcinoma is similar in certain morphological and genetic features to metanephric adenoma, suggesting that they might be related.
Ngan
K W
KW
Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
Ng
K F
KF
Chuang
C K
CK
D002291:Carcinoma, Papillary / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male