title: Distribution of GyrA intein in non-tuberculous mycobacteria and genomic heterogeneity of Mycobacterium gastri.
abstract: To gain further insights into the understanding of the intein invasion process in mycobacteria, intein sequences in the gyrA gene of 42 mycobacterial strains were searched and a new gyrA intein was found in Mycobacterium gastri (Mga). This 1260 bp intein, named MgaGyrA, inserted at the GyrA-a site, is highly homologous to the members of the Mycobacterium leprae GyrA allelic family. As the recA intein, MgaGyrA was detected in only one out of six Mga strains examined, while the pps1 intein was a constant character of Mga. This data supports the genomic heterogeneity of Mga towards intein invasion, a finding that may have phylogenetic implications.
authors.affiliation: Institut de Pharmacologie et Biologie Structurale, UMR 5089 CNRS/UPS, 205 Route de Narbonne, F-31077 Toulouse Cedex, France. saves@ipbs.fr
authors.forename: I
authors.initials: I
authors.lastname: Saves
authors.forename: M
authors.initials: M
authors.lastname: Daffé
authors.forename: J M
authors.initials: JM
authors.lastname: Masson
authors.forename: S
authors.initials: S
authors.lastname: Isabelle
authors.forename: D
authors.initials: D
authors.lastname: Mamadou
authors.forename: M
authors.initials: M
authors.lastname: Jean-Michel
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D027081:DNA Gyrase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D009161:Mycobacterium / Q000235:genetics* / Q000378:metabolism; D019154:Protein Splicing; D011938:Rec A Recombinases / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D001426:Bacterial Proteins; D011938:Rec A Recombinases; D027081:DNA Gyrase