title: The in vitro study of influence of four novel platinum compounds on rodent melanoma cells.
abstract: The purpose of this study was to assess cytotoxic effect of four new platinum compounds on B16 and CIS91 melanoma cells in vitro. The following complexes were tested: (2) Tetrachlorobis (5,7-dimethyl-1,2,4-triazol [1,5alpha] pirymidine) platinum (IV), (3) trans-dichloro (dimethylsulfoxide) (5,7-dimetyl-1,2,4-triazol-[1,5alpha] pirymidine) platinum(II), (4) cis-dichloro(dimethylsulfoxide)(1-beta-D-ribofuranosyl-1,2,4-triazol-3-carboxamide)platinum(II), (5) chloro(dimethylsulfoxide)(1-beta-D-ribofuranosyl-1,2,4-triazol-3-carboxamide)platinum(II). We can conclude, that Pt-dmtp (2) represented the best cytotoxic properties in the group of four tested platinum compounds, Pt-rib-1 (4) has also a good cytotoxic properties although its IC50 value is quite high. We suppose that cytotoxic and soluble properties ot Pt-dmtp and Pt-rib-1 could be modified and improved.
authors.affiliation: Department of Human Biology, Ludwik Rydygier Medical University, Bydgoszcz, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Drewa
authors.forename: A
authors.initials: A
authors.lastname: Woźniak
authors.forename: D
authors.initials: D
authors.lastname: Olszewska
authors.forename: E
authors.initials: E
authors.lastname: Szłyk
authors.forename: I
authors.initials: I
authors.lastname: Lakomska
authors.forename: C
authors.initials: C
authors.lastname: Mila-Kierzenkowska
authors.forename: R
authors.initials: R
authors.lastname: Czajkowski
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds