title: Microdose gentamicin administration via the round window microcatheter: results in patients with Meniere's disease.
abstract: Transtympanic gentamicin is becoming increasingly popular in the treatment of Meniere's disease. In this report we examine our experience with the use of microdose gentamicin via the Round Window Microcatheter for the treatment of Meniere's disease. Thirty-six patients were treated with gentamicin administration via the Round Window Microcatheter between July 1997 and August 2000. The patients all underwent 10 days of continuous treatment with a total dose of 2.4-3.75 mg of gentamicin (10 mg/ml). All patients had extensive pre-, intra-, and post-therapy auditory and vestibular testing. In this group, vertigo was eliminated in 89% of the patients, and tinnitus and pressure were significantly reduced in over 60% of the patients. Only one patient suffered a significant hearing loss and, most importantly, in all but one patient vestibular function was improved or normalized after treatment. Round Window Microcatheter-administered microdose gentamicin is an exciting new treatment for Meniere's disease. Preliminary results indicate that vertigo can be controlled without a significant reduction in cochlear or vestibular function in most patients. These results suggest that this therapy may be acting at a non-hair cell site. Our results are compared to the published literature examining transtympanic injection. In addition, the underlying science supporting this type of treatment is examined.
authors.affiliation: The Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, California 93124-2200, USA. mehoffer@nmcsd.med.navy.mil
authors.forename: M E
authors.initials: ME
authors.lastname: Hoffer
authors.forename: R D
authors.initials: RD
authors.lastname: Kopke
authors.forename: P
authors.initials: P
authors.lastname: Weisskopf
authors.forename: K
authors.initials: K
authors.lastname: Gottshall
authors.forename: K
authors.initials: K
authors.lastname: Allen
authors.forename: D
authors.initials: D
authors.lastname: Wester
mesh_terms: D000328:Adult; D000368:Aged; D001299:Audiometry; D001300:Audiometry, Evoked Response; D002404:Catheterization; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D011187:Posture; D012405:Round Window, Ear; D016896:Treatment Outcome; D014717:Vertigo / Q000188:drug therapy; D014787:Vision Tests
chemical_list: D005839:Gentamicins