title: Polymorphisms in the vicinity of the hypocretin/orexin are not associated with human narcolepsy.
abstract: Human narcolepsy/cataplexy is associated with reduced hypocretin (orexin) transmission. A common preprophypocretin (HCRT) polymorphism (-909C/T) was identified and tested in 502 subjects (105 trio families, 80 Caucasian narcolepsy cases, and 107 Caucasian control subjects). This polymorphism was not associated with the disease. The promoter and 5' untranslated (5'URT) regions of the HCRT gene (-320 to +21 from ATG) were also sequenced in 281 subjects. None of the subjects carried -22T, a rare 5'UTR polymorphism previously reported to be associated with narcolepsy. The HCRT locus is not a major narcolepsy susceptibility locus.
authors.affiliation: Stanford Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, CA 94305-5485, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hungs
authors.forename: L
authors.initials: L
authors.lastname: Lin
authors.forename: M
authors.initials: M
authors.lastname: Okun
authors.forename: E
authors.initials: E
authors.lastname: Mignot
mesh_terms: D000328:Adult; D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000175:diagnosis / Q000235:genetics*; D009479:Neuropeptides / Q000235:genetics*; D000068797:Orexins; D011110:Polymorphism, Genetic; D017286:Polysomnography; D011401:Promoter Regions, Genetic; D011498:Protein Precursors / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D011498:Protein Precursors