Prenatal exposure to magnetic field increases dopamine levels in the striatum of offspring.
1. The putative effects of prenatal exposure to magnetic field (MF) have recently received much interest. In the present study, mice were exposed to a MF of 50 mT during gestation (0-19 days). 2. After the exposure was terminated, mothers and offspring were returned to normal laboratory conditions. We then determined changes in striatal levels of dopamine (DA) and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the offspring. 3. Our results indicate that prenatal exposure to MF increases levels of DA and DOPAC in the striatum at 4, 8 and 12 weeks postnatally.
Lee
B C
BC
Neurotoxicology Program, College of Pharmacy, Kangwon National University, Korea Institute of Drug Abuse, Chunchon.
Bing
G
G
Jhoo
W K
WK
Yoon
J M
JM
Kang
K S
KS
Shin
E J
EJ
Kim
W K
WK
Ko
K H
KH
Kim
H C
HC
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000196:embryology / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D008280:Magnetics / Q000009:adverse effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine