title: A novel phosphorylcholine-coated contact lens for extended wear use.
abstract: The preparation and characterisation of a new phosphorylcholine (PC)-coated silicone hydrogel contact lens for use in extended wear is described. The Michael-type addition of amines to acrylates forms the basis of the synthesis of a novel silicone-based macromer with hydrophilic functionality. It is demonstrated that this macromer can be combined with other silicone-based monomers, hydrophilic monomers and crosslinker to produce a contact lenses formulation. Examples of lenses with water contents of 33% and 46% are illustrated and their properties compared to other commercially available lenses. Materials with comparatively low modulus (<0.3 MPa) and adequate tear strength (>2-4MPa) with excellent elongation to break (>200%) can be obtained using this technology. In addition to the mechanical aspects. both the oxygen and solute permeabilities of the material can be controlled by the hydrophilic: hydrophobic monomer balance in the formulation. to obtain materials with attributes suitable for extended wear use. The PC coating is achieved by means of an in-mould coating (IMC) technique that produces a uniform and stable surface as determined by staining and XPS. The coating imparts both improved lens wettability (advancing contact angle of approximately 50 with virtually no hysteresis) and lower protein adsorption relative to the uncoated lens.
authors.affiliation: Biocompatibles Limited, Farnham, Surrey, UK. sean_willis@biocompatibles.co.uk
authors.forename: J L
authors.initials: JL
authors.lastname: Court
authors.forename: R P
authors.initials: RP
authors.lastname: Redman
authors.forename: J H
authors.initials: JH
authors.lastname: Wang
authors.forename: S W
authors.initials: SW
authors.lastname: Leppard
authors.forename: V J
authors.initials: VJ
authors.lastname: Obyrne
authors.forename: S A
authors.initials: SA
authors.lastname: Small
authors.forename: A L
authors.initials: AL
authors.lastname: Lewis
authors.forename: S A
authors.initials: SA
authors.lastname: Jones
authors.forename: P W
authors.initials: PW
authors.lastname: Stratford
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D001698:Biomedical Engineering; D003262:Contact Lenses, Extended-Wear; D004203:Disinfection; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry; D066298:In Vitro Techniques; D008422:Materials Testing; D010100:Oxygen; D010767:Phosphorylcholine / Q000138:chemical synthesis / Q000737:chemistry; D011506:Proteins / Q000493:pharmacokinetics; D020034:Silicone Gels / Q000138:chemical synthesis / Q000737:chemistry; D013194:Staining and Labeling; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D011506:Proteins; D020034:Silicone Gels; D010767:Phosphorylcholine; D010100:Oxygen