title: Connection between foreign DNA replication and induced expression of the restriction-modification system in Streptomyces aureofaciens.
abstract: Tetracycline-producing strains of Streptomyces aureofaciens expressed SauLPI restriction-modification (R-M) system, which recognized specific DNA sequence 5'-GCCGGC-3' (isoschizomer Nael). The activation of the second R-M system SauLPII (5'-GAGCTC-3', isoschizomer of XhoI), which was silent during the growth cycle, after a foreign DNA transfer into this strain was observed. This phenomenon was tentatively explained as a response of the cells against the exogenous DNA entering the cells. The involvement of a SOS-like response in induction of R-M system genes in S. aureofaciens strains has been considered.
authors.affiliation: Institute of Molecular Biology, Slovak Academy of Sciences, 842 51 Bratislava, Slovakia.
authors.forename: A
authors.initials: A
authors.lastname: Godány
authors.forename: J
authors.initials: J
authors.lastname: Farkasovská
authors.forename: G
authors.initials: G
authors.lastname: Bukovská
authors.forename: J
authors.initials: J
authors.lastname: Timko
mesh_terms: D010583:Bacteriophage mu / Q000235:genetics; D004261:DNA Replication; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D013014:SOS Response, Genetics; D013304:Streptomyces aureofaciens / Q000201:enzymology* / Q000235:genetics*
chemical_list: C034510:CTCGAG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific