title: Different antiphospholipid antibody specificities are found in association with early repeated pregnancy loss versus recurrent IVF-failure patients.
abstract: OBJECTIVE
  Patients having in vitro fertilization and embryo transfer (IVF-ET) failures show an increased incidence of antiphospholipid (aPL) antibodies; but controversy exists whether aPL can induce IVF-failure. This study was designed to compare aPL specificities between recurrent IVF-failure patients versus repeated early pregnancy loss (RPL) patients.
  
  
  METHODS
  Anticardiolipin (aCL), lupus anticoagulant (LA), antiphosphatidylserine (aPS), antiphosphatidylethanolamine (aPE), and antinuclear antibodies (ANA) were measured in 74 recurrent IVF-ET failure patients and compared with 273 early RPL patients ( < 10 weeks).
  
  
  RESULTS
  An increased incidence of IgG-aPE and ANA was observed for both groups in comparison with controls. Patients with recurrent IVF-ET failure showed a significantly higher prevalence of IgG-aPS (P = 0.02) and IgG-aCL (P = 0.02) when compared with early RPL patients or controls.
  
  
  CONCLUSIONS
  IgG-aPS and IgG-aCL may be responsible for some IVF-failures. Additional studies are needed to clarify the pathogenic role of IgG-aPS and IgG-aCL on IVF-ET failure.
authors.affiliation: Department of Obstetrics and Gynecology, Center for Growth and Reproductive Medicine, Tokai University School of Medicine, Kanagawa, Japan. hide-m@is.icc.u-tokai.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Matsubayashi
authors.forename: T
authors.initials: T
authors.lastname: Sugi
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: A
authors.initials: A
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Izumi
authors.forename: J A
authors.initials: JA
authors.lastname: McIntyre
authors.forename: T
authors.initials: T
authors.lastname: Makino
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology* / Q000276:immunology; D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D000918:Antibody Specificity; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy
chemical_list: D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid