Daphnicyclidins A-H, novel hexa- or pentacyclic alkaloids from two species of Daphniphyllum.
Eight highly modified Daphniphyllum alkaloids with unprecedented fused hexa- or pentacyclic skeletons, daphnicyclidins A-H (1-8), have been isolated from the stems of Daphniphyllum humile and D.teijsmanni, and their structures were elucidated on the basis of spectroscopic data and chemical means. The stereochemistry was elucidated by combination of NOESY correlations, X-ray crystallographic data, and CD analyses.
Kobayashi
J I
JI
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp
Inaba
Y
Y
Shiro
M
M
Yoshida
N
N
Morita
H
H
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism; D014197:Trees / Q000737:chemistry*
D000470:Alkaloids