title: Synthesis and antimicrobial activity of new 3 alpha-hydroxy-23,24-bisnorcholane polyamine carbamates.
abstract: 3 alpha-Hydroxy-23,24-bisnorcholane spermidine and spermine carbamates 2-7 have been synthesized and their antimicrobial and hemolytic activities were evaluated. They exhibited excellent in vitro activities especially against methicillin-resistant Staphylococcus aureus.
authors.affiliation: Department of Industrial Chemistry, Kyungpook National University, Taegu 702-701, South Korea. kimhs@knu.ac.kr
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: K C
authors.initials: KC
authors.lastname: Kwon
authors.forename: K S
authors.initials: KS
authors.lastname: Kim
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D002219:Carbamates / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D011073:Polyamines / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002219:Carbamates; D011073:Polyamines