title: Syntheses and biological evaluation of alkanediamines as antioxidant and hypolipidemic agents.
abstract: A new series of compounds belonging to N,N'- [bis (1-aryl-6-hydroxy-hex-2-ene-1-one-3-yl)-1,n-alkanediamines (2-5a-f) have been synthesized and evaluated for antioxidant and hypolipidemic activities. Amongst all the synthesized compounds, seven compounds namely 2c, 2e, 4c, 5b, 5c, 5e and 5f exhibit potent antioxidant activity. These compounds have also been evaluated for hypolipidemic activity.
authors.affiliation: Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India. batra_san@yahoo.co.uk
authors.forename: S
authors.initials: S
authors.lastname: Batra
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
authors.forename: B S
authors.initials: BS
authors.lastname: Joshi
authors.forename: R
authors.initials: R
authors.lastname: Roy
authors.forename: A K
authors.initials: AK
authors.lastname: Khanna
authors.forename: R
authors.initials: R
authors.lastname: Chander
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D003959:Diamines / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D006493:Heparin / Q000378:metabolism; D006801:Humans; D017665:Hydroxyl Radical; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D011092:Polyethylene Glycols / Q000633:toxicity; D051381:Rats
chemical_list: D000475:Alkenes; D000975:Antioxidants; D003959:Diamines; D000960:Hypolipidemic Agents; C448879:N,N'-bis(1-(4-chlorophenyl-6-hydroxy-hex-2-ene-1-one-3-yl)-1,2-ethanediamine); C448880:N,N'-bis(1-(4-methoxyphenyl-6-hydroxy-hex-2-ene-1-one-3-yl)-1,2-ethanediamine); D017665:Hydroxyl Radical; D011092:Polyethylene Glycols; D006493:Heparin; C016811:tyloxapol