title: A new approach to enhancement of bone formation by electrically polarized hydroxyapatite.
abstract: An electrical field may affect osteogenesis. Since we found that hydroxyapatite (HA) ceramics may be polarizable, we hypothesized that electrically polarized HA may foster production of new bone in vivo. Both polarized and non-polarized HA ceramics were inserted into the subperiosteum spaces at the parietal bone area of rats. After 2, 4, and 8 weeks, the implant sites were examined histologically. Morphometric analysis revealed that new bone formation was accelerated on the negatively charged surface of the polarized HA (N-surface) at 2 weeks. The newly formed bone approached maturation at 4 weeks and was thicker on the N-surface than in the controls. By 8 weeks, newly formed bone in the controls was almost the same as that on the N-surface. These findings suggest that polarized HA is biocompatible and that bone formation on the N-surface is enhanced in the early stage of bone healing.
authors.affiliation: Division of Developmental Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Japan. diana.pedo@dent.tmd.ac.jp
authors.forename: N C
authors.initials: NC
authors.lastname: Teng
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Takagi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Ohgaki
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use; D017886:Durapatite / Q000737:chemistry* / Q000627:therapeutic use; D004560:Electricity; D004563:Electrochemistry; D004566:Electrodes; D005500:Follow-Up Studies; D006358:Hot Temperature; D008297:Male; D023421:Models, Animal; D010012:Osteogenesis / Q000502:physiology*; D010294:Parietal Bone / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D010521:Periosteum / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D010984:Platinum; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D010984:Platinum; D017886:Durapatite