title: Extranodal cytotoxic T-cell lymphoma in a patient with X-linked agammaglobulinaemia.
abstract: This report documents the occurrence of an extranodal cytotoxic peripheral T-cell lymphoma (PTCL) in a patient with X-linked agammaglobulinaemia (XLA). The diagnosis was based on the immunohistochemical detection of T-cell antigens and of the cytotoxic proteins TIA1 and Granzyme B in the tumour cells. This report provides further evidence that cytotoxic lymphomas are part of the differential diagnosis of neoplasia in patients with immunodeficiencies.
authors.affiliation: Department of Histology, Medical Faculty, University of Thessalia, Hellas.
authors.forename: P
authors.initials: P
authors.lastname: Kanavaros
authors.forename: D
authors.initials: D
authors.lastname: Rontogianni
authors.forename: D
authors.initials: D
authors.lastname: Hrissovergi
authors.forename: A
authors.initials: A
authors.lastname: Efthimiadoy
authors.forename: T
authors.initials: T
authors.lastname: Argyrakos
authors.forename: K
authors.initials: K
authors.lastname: Mastoris
authors.forename: K
authors.initials: K
authors.lastname: Stefanaki
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000235:genetics; D053804:Granzymes; D006801:Humans; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins / Q000032:analysis; D012697:Serine Endopeptidases / Q000032:analysis; D000074019:T-Cell Intracellular Antigen-1; D013602:T-Lymphocytes, Cytotoxic / Q000473:pathology*; D014960:X Chromosome
chemical_list: D008565:Membrane Proteins; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases