Prolactin receptor signal transduction.
Within the immune system, multiple isoforms of the human prolactin receptor (PRLr) serve to mediate the effects of its ligand (PRL). Now numbering four, these isoforms are structurally and functionally distinct, demonstrating significant differences in ligand affinities, kinetics of transduction and the transduction proteins activated. The proximal transduction pathways activated during PRLr-associated signaling include the tyrosine kinases Jak2, Fyn and Tec, the phosphatase SHP-2, the guanine nucleotide exchange factor Vav, and the signaling suppressor SOCS. Differential activation of these pathways may contribute to the pleiotropism of PRL action in tissues of the immune system.
Clevenger
C V
CV
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19066, USA. clevengc@mail.med.upenn.edu
Kline
J B
JB
D000818:Animals; D020869:Gene Expression Profiling; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D006801:Humans; D020033:Protein Isoforms / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011981:Receptors, Prolactin / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
D020662:Guanine Nucleotide Exchange Factors; D020033:Protein Isoforms; D011981:Receptors, Prolactin; D011505:Protein-Tyrosine Kinases