title: Attenuation of Endothelium-Dependent Relaxation in Mesenteric Artery during Noise-Induced Hypertension.
abstract: The present study was designed to determine whether there is a causal relationship between noise-induced hypertension and changes of endothelial function. Rats were exposed to noise stress (100 dB, 1 kHz, 4 h/day, 6 days/week) for 1-4 weeks. The systolic blood pressure was significantly increased after rats were exposed to noise stress for 3 weeks. The relaxant responses of isolated mesenteric arterial rings to endothelium-dependent vasodilators (A23187 and acetylcholine) in noise-treated rats were significantly less than those in control rats. This difference in response to acetylcholine still existed in the presence of methylene blue or N(omega)-nitro-L-arginine. On the other hand, the responses to the endothelium-dependent vasodilator nitroglycerin were not affected in rats exposed to noise stress. The attenuation to endothelium-dependent vasodilators during noise stress may result in increasing peripheral vascular resistance and thus elevate blood pressure. This indicates that noise-induced hypertension may be partly due to the alterations of endothelial activity. Copyright 1994 S. Karger AG, Basel
authors.affiliation: Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, ROC.
authors.forename: C.C.
authors.initials: CC
authors.lastname: Wu
authors.forename: S.J.
authors.initials: SJ
authors.lastname: Chen
authors.forename: M.H.
authors.initials: MH
authors.lastname: Yen