Systemic inflammatory response syndrome and acute neurological disease.
Systemic inflammatory response syndrome is a common clinical entity often presenting as a complication of neurological disease or trauma. Clear diagnostic criteria exist. Induced pathological mechanisms include both immunological and endothelial dysfunction, and coagulopathy, which may lead to multiple organ failure and significant morbidity. Possible therapeutic mechanisms are discussed, but this complex syndrome is poorly understood and successful treatment may depend on further research into control mechanisms.
Malham
G M
GM
Departments of Neurosurgery, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK.
Souter
M J
MJ
D001778:Blood Coagulation Disorders / Q000209:etiology*; D016207:Cytokines / Q000502:physiology*; D003937:Diagnosis, Differential; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology* / Q000503:physiopathology; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy
D016207:Cytokines