Thromboxane A2 signalling in humans: a 'Tail' of two receptors.
Since its discovery in 1975, we now have a wealth of knowledge relating to the biochemical, pharmacological and physiological actions of thromboxane A(2) (TXA(2)) and its related metabolites. These molecular insights have been greatly expedited by the molecular cloning and characterization of a cDNA for the human TXA(2) receptor, now termed the T Prostanoid or TP receptor, from a megakaryocytic/placental cDNA library in 1991, and later through the discovery of a cDNA encoding a second isoform of the human TP receptor in 1994. The requirement for two TP receptors in primates, but not in other species thus far investigated, is unclear, but points to potential species-specific physiological differences. In this review, I will describe some recent advances in the research field of TXA(2)/TP receptor signalling, focusing particularly on studies pertaining to the human TP receptor isoforms.
Kinsella
B T
BT
Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, Merville House, University College Dublin, Belfield, Dublin 4, Ireland. Therese.Kinsella@UCD.ie
D000595:Amino Acid Sequence; D000818:Animals; D018076:DNA, Complementary / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D020033:Protein Isoforms; D017482:Receptors, Thromboxane / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction; D013928:Thromboxane A2 / Q000378:metabolism*; D013997:Time Factors
D018076:DNA, Complementary; D020033:Protein Isoforms; D017482:Receptors, Thromboxane; D013928:Thromboxane A2; D019204:GTP-Binding Proteins