Caenorhabditis elegans: how good a model for veterinary parasites?
The organism about which most is known on a molecular level is a nematode, the free-living organism Caenorhabditis elegans. This organism has served as a reasonable model for the discovery of anthelmintic drugs and for research on the mechanism of action of anthelmintics. Useful information on mechanisms of anthelmintic resistance has also been obtained from studies on C. elegans. Unfortunately, there has not been a large-scale extension of genetic techniques developed in C. elegans to research on parasitic species of veterinary (or human) parasites. Much can be learned about the essentials of nematode biology by studying C. elegans, but discovering the basic biology of nematode parasitism can only be gained through comparative studies on multiple parasitic species.
Geary
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TG
Discovery Research, Pharmacia Animal Health, 7923-25-111, 7000 Portage Road, Kalamazoo, MI 49001-0199, USA. timothy.g.geary@pharmacia.com
Thompson
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DP
D000818:Animals; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D017238:Genes, Helminth / Q000502:physiology*; D018503:Genome, Protozoan; D008954:Models, Biological; D010802:Phylogeny