title: [Postoperative opacification of 12 hydrogel foldable lenses (Hydroview(R))].
abstract: BACKGROUND
  To evaluate postoperative lens opacifications in foldable hydrophilic intraocular lenses.
  
  
  METHODS
  12 patients (9 female; 3 male; mean age 77.5 +/- 3 years) were referred from one ophthalmologic surgeon because of opacification of IOLs and markedly decreased visual acuity. Time between implantation and explantation varied from 8 month to 3 years. IOL explantation was performed in all 12 patients and IOL were examined by light-, transmission- and scanning electron microscopy.
  
  
  RESULTS
  IOL-explantation was uneventful in all 12 patients. The explanted IOLs showed crystalline deposits 0.5 to 2 microm in diameter immediately beneath the surface of the lens. Eight of 12 patients had elevated serum levels for glucose (6 patients with manifest diabetes mellitus, 2 patients with pathological elevated levels for glucose).
  
  
  CONCLUSIONS
  Postoperative opacification of hydrogel foldable lenses (Hydroview(R)) are apperantly caused by formation of crystalline deposits beneath the lens surface. These deposits may be associated with metabolic disorders, e.g. diabetes mellitus.
authors.affiliation: Augenklinik mit Poliklinik der Universität Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen. michael.groh@augen.med.uni-erlangen.de
authors.forename: M J
authors.initials: MJ
authors.lastname: Groh
authors.forename: U
authors.initials: U
authors.lastname: Schlötzer-Schrehardt
authors.forename: C
authors.initials: C
authors.lastname: Rummelt
authors.forename: H
authors.initials: H
authors.lastname: von Below
authors.forename: M
authors.initials: M
authors.lastname: Küchle
mesh_terms: D000327:Adsorption; D000368:Aged; D000369:Aged, 80 and over; D018916:Blood-Aqueous Barrier; D003460:Crystallization; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020100:Hydrogels / Q000009:adverse effects* / Q000493:pharmacokinetics; D007910:Lenses, Intraocular; D008297:Male; D019591:Pseudophakia / Q000150:complications*; D012086:Reoperation; D014786:Vision Disorders / Q000209:etiology* / Q000378:metabolism; D014792:Visual Acuity
chemical_list: D020100:Hydrogels