Comparative study of disintegrated cells influence of Staphylococcus aureus, Escherichia coli and Candida albicans on human and mouse immune mechanisms.
The study presents comparison of immunomodulatory effects of Staphylococcus aureus, Escherichia coli and Candida albicans disintegrated cells on selected immune mechanisms of human and mouse leukocytes. We measured their phagocytic activity, phagocytic index and microbicidal activity against Staphylococcus aureus, Escherichia coli and Candida albicans cells as well as peroxidase and lysozyme activities of human and mouse leukocytes. Our results revealed predominantly inhibitory effect of disintegrated microorganisms on nonspecific immune functions of human leukocytes, but mainly stimulatory effect on mouse leukocytes monitored immune functions.
Bukovsky
M
M
Dept of Molecular and Cellular Biology of Drugs, Faculty of Pharmacy, Comenius University, Odbojarov 10, SK-832 32 Bratislava, Slovakia. bukovsky@fpharm.uniba.sk
Koscova
H
H
Dubnickova
M
M
Sirotkova
L
L
D000276:Adjuvants, Immunologic; D000818:Animals; D001770:Blood Bactericidal Activity; D002176:Candida albicans / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010587:Phagocytosis; D013211:Staphylococcus aureus / Q000276:immunology*
D000276:Adjuvants, Immunologic