title: GABA(A)-receptor subtypes: a new pharmacology.
abstract: The GABA(A) receptor is a pluripotent drug target mediating anxiolytic, sedative, anticonvulsant, muscle relaxant and amnesic activity. These drug actions have now been attributed to defined receptor subtypes. Thus, precise guidelines are available for the development of novel drugs with more selective action and less side effects than those currently in clinical use.
authors.affiliation: Institute of Pharmacology and Toxicology, University of Zürich, Switzerland. mohler@pharma.unizh.ch
authors.forename: H
authors.initials: H
authors.lastname: Möhler
authors.forename: F
authors.initials: F
authors.lastname: Crestani
authors.forename: U
authors.initials: U
authors.lastname: Rudolph
mesh_terms: D000647:Amnesia / Q000188:drug therapy; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D001665:Binding Sites / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects*; D012640:Seizures / Q000517:prevention & control
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D011963:Receptors, GABA-A