Presence of VZV and HSV-1 DNA in human nodose and celiac ganglia.
Polymerase chain reaction (PCR) revealed herpes simplex virus (HSV) and varicella zoster virus (VZV) DNA in human nodose and celiac ganglia. This is the first detection of VZV DNA in ganglia of the human autonomic nervous system. The ability of reactivated VZV to produce serious, sometimes fatal neurological disease in the absence of rash, raises the possibility that VZV reactivation from autonomic ganglia might be involved in visceral disease.
Gilden
D H
DH
Department of Neurology, University of Colorado Health Sciences Center, School of Medicine, Denver 80262, USA. don.gilden@uchsc.edu
Gesser
R
R
Smith
J
J
Wellish
M
M
Laguardia
J J
JJ
Cohrs
R J
RJ
Mahalingam
R
R
D000368:Aged; D000369:Aged, 80 and over; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005728:Ganglia, Sympathetic / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009620:Nodose Ganglion / Q000821:virology*; D016133:Polymerase Chain Reaction; D014775:Virus Activation
D004279:DNA, Viral