Partial unilateral ureteropelvic junction obstruction induced in 2-week-old piglets.
OBJECTIVE
We examined effects on kidney function and morphology of a partial ureteropelvic junction obstruction induced late in the postnatal nephrogenesis period of the pig. We compared the results to a similar study on pigs with obstruction induced early in the nephrogenesis period.


METHODS
A total of 20 14-day-old pigs were included in the study. Fifteen animals were randomized to partial unilateral obstruction and 5 were sham operated. Kidney function and morphology were analyzed regarding glomerular filtration rate, renographic functional share and total kidney volume at the age of 4, 12 and 24 weeks.


RESULTS
At age 4 weeks hydronephrosis was found in all obstructed kidneys included in the study. Four obstructed kidneys had renographic functional share 40% or greater and 1 deteriorated to less than 40% at 24 weeks. A total of 11 obstructed kidneys had a functional share less than 40%, 5 increased to a share greater than 40% at age 24 weeks and 3 had decreasing share from age 4 to 24 weeks. Single kidney glomerular filtration rate of the contralateral kidneys was significantly increased at all ages. Volume of the contralateral kidney was significantly increased at age 4 and 12 weeks.


CONCLUSIONS
The variability and course of renographic functional share in kidneys subjected to partial obstruction at age 2 weeks was similar to findings obtained in pigs obstructed at age 2 days. In contrast to these our study showed compensatory increase in function and size of the contralateral kidney, suggesting that contralateral compensation is an ability gained late in the nephrogenesis period.
Dissing
T H
TH
Institute of Experimental Clinical Research, University of Aarhus, Department of Clinical Physiology and Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark.
Eskild-Jensen
A
A
Pagh
C
C
Frokiaer
J
J
Rehling
M
M
Jørgensen
H S
HS
Jørgensen
T M
TM
Djurhuus
J C
JC
D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D007682:Kidney Pelvis; D013552:Swine; D014517:Ureteral Obstruction / Q000503:physiopathology