2-5A-antisense chimeras: inhibitors of respiratory syncytial virus infection.
A new approach to the chemical control of respiratory syncytial virus infection is reviewed in the context of the biology of the virus and previous treatment approaches. Conjugation of the interferon action mediator, 2',5'-oligoadenylate (2-5A), to antisense agents provides a strategy for the selective ablation of RNA. This application of this technology to respiratory syncytial virus has provided a potent selective inhibitor of virus replication.
Torrence
P F
PF
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0805, USA. torrence@helix.nih.gov
D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics / Q000378:metabolism; D000227:Adenine Nucleotides / Q000737:chemistry / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D016375:Antisense Elements (Genetics) / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D015195:Drug Design; D004722:Endoribonucleases / Q000378:metabolism; D004790:Enzyme Induction; D006801:Humans; D007223:Infant; D007372:Interferons / Q000502:physiology*; D008958:Models, Molecular; D009843:Oligoribonucleotides / Q000737:chemistry / Q000494:pharmacology*; D012330:RNA, Double-Stranded / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D012367:RNA, Viral / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D013379:Substrate Specificity; D014779:Virus Replication / Q000187:drug effects
D000227:Adenine Nucleotides; D016375:Antisense Elements (Genetics); D000998:Antiviral Agents; D009843:Oligoribonucleotides; D012330:RNA, Double-Stranded; D012367:RNA, Viral; C023505:2',5'-oligoadenylate; D000255:Adenosine Triphosphate; D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease