Molecular mechanisms of developmental timing in C. elegans and Drosophila.
Characterization of the heterochronic genes has provided a strong foundation for understanding the molecular mechanisms of developmental timing in C. elegans. In apparent contrast, studies of developmental timing in Drosophila have demonstrated a central role for gene cascades triggered by the steroid hormone ecdysone. In this review, I survey the molecular mechanisms of developmental timing in C. elegans and Drosophila and outline how common regulatory pathways are beginning to emerge.
Thummel
C S
CS
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City 84112, USA. carl.thummel@genetics.utah.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics; D004330:Drosophila / Q000196:embryology* / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins