Therapeutic aspects of tolerance.
The immune system is naturally unresponsive to 'self' antigens. Improved knowledge of mechanisms underlying self tolerance is giving rise to a new generation of immunosuppressive agents, that can exploit these mechanisms and so reduce the nature and level of medication that needs to be given long-term to control diseases where the immune system does harm.
Waldmann
H
H
Sir William Dunn School of Pathology, Oxford, UK. herman.waldmann@path.ox.ac.uk
Cobbold
S P
SP
Fairchild
P
P
Adams
E
E
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D000954:Antigens, Surface / Q000187:drug effects / Q000276:immunology; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects* / Q000502:physiology*; D007112:Immunity, Maternally-Acquired; D016377:Organ Transplantation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface