title: Novel approaches to the treatment of progressive renal disease.
abstract: Diabetes and hypertension are major contributors to the increasing incidence of progressive renal disease. In addition to more potent antihypertensive agents that block the renin-angiotensin system, drugs that modulate other pathogenetic pathways are also in development. Recent preclinical studies indicate that compounds that interfere with the formation and action of advanced glycation end products may have a role in the treatment and prevention of diabetic nephropathy, as may agents targeting the activity of protein kinase C.
authors.affiliation: University of Melbourne Department of Medicine, St Vincent's Hospital, Fitzroy, Victoria 3065, Australia. gilbert@medstv.unimelb.edu.au
authors.forename: R E
authors.initials: RE
authors.lastname: Gilbert
authors.forename: D J
authors.initials: DJ
authors.lastname: Kelly
authors.forename: R C
authors.initials: RC
authors.lastname: Atkins
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002986:Clinical Trials as Topic; D003928:Diabetic Nephropathies / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control; D007674:Kidney Diseases / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D015260:Neprilysin / Q000037:antagonists & inhibitors; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors; D012084:Renin-Angiotensin System / Q000187:drug effects; D015398:Signal Transduction
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D011493:Protein Kinase C; D015260:Neprilysin