Cervical dysplasia in pregnancy: progression versus regression post-partum.
OBJECTIVE
To assess the natural history of cervical dysplasia during pregnancy and determine the rates for progression or regression post-partum by the severity of the lesion.


METHODS
This was a retrospective study of 100 patients screened by PAP smear. Lesions were graded by colposcopy and biopsy, and followed post-partum.


RESULTS
Lesions were graded as ASCUS, LGSIL, and HGSIL. The majority of lesions showed a tendency to regress post-partum (approximately 64%), a trend that was statistically significant (P < .003). A substantial minority (approximately 34%) showed no change in severity of the lesion. The tendency for lesions to progress in severity was very low (approximately 3%). No patient had microinvasive disease. Of patients who had CIS, persistence of this lesion post-partum was present in 67%.


CONCLUSIONS
Patients with cervical dysplasia in pregnancy may be followed conservatively with colposcopy and biopsy.
Siddiqui
G
G
Department of Obstetrics and Gynecology, Mount Sinai Hospital Medical Center, Chicago, Illinois, USA.
Kurzel
R B
RB
Lampley
E C
EC
Kang
H S
HS
Blankstein
J
J
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003127:Colposcopy; D018450:Disease Progression; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D049590:Postpartum Period; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D002578:Uterine Cervical Dysplasia / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears