title: Cone biopsy and pathologic findings at radical hysterectomy in stage I cervical carcinoma.
abstract: OBJECTIVE
  To examine the association between cone biopsy and pathologic findings at radical hysterectomy in stage I cervical carcinoma.
  
  
  METHODS
  Fifty-four patients diagnosed by cone biopsy with stage I cervical carcinoma and treated with radical hysterectomy comprised the study group. The association between the depth of invasion on conization, lymph-vascular invasion, positive cone margins, positive endocervical curettage (ECC), and the depth of residual invasion in the radical hysterectomy specimen was examined using Pearson r and point biserial correlation. Independent predictors of the depth of residual invasion were determined by multiple regression.
  
  
  RESULTS
  The depth of residual invasion correlated significantly with the depth of invasion (r =.374) and presence of lymph-vascular invasion (r(pb)=.372) in the conization specimen, post-cone ECC status (r(pb) =.669), and age at diagnosis (r =.347). The same factors were jointly assessed using multiple regression (R(2) =.636, P<.001). Depth of invasion on conization, lymph-vascular invasion, and ECC status were identified as independent predictors of the depth of residual invasion. Patients with deep (5 mm or greater) stromal invasion and lymph-vascular invasion on conization had significantly higher rates of positive parametrial margins (22% compared with zero, P =.001) and adjuvant radiation (66.7% compared with 20%, P =.004) compared with all other patients.
  
  
  CONCLUSIONS
  Depth of invasion, presence of lymph-vascular invasion, and age at diagnosis were independent predictors of the depth of residual invasion in the subsequent hysterectomy specimen. These factors should be considered in treatment planning. Patients with a combination of these factors may have increased risk for deep residual invasion, positive hysterectomy margins, and adjuvant radiation.
authors.affiliation: Department of Obstetrics and Gynecology, State University of New York Health Science Center, Brooklyn, New York, USA. kholcombe@chpnet.org
authors.forename: K
authors.initials: K
authors.lastname: Holcomb
authors.forename: T M
authors.initials: TM
authors.lastname: Dimaio
authors.forename: A D
authors.initials: AD
authors.lastname: Nicastri
authors.forename: R P
authors.initials: RP
authors.lastname: Matthews
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Buhl
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology*; D019092:Conization; D005260:Female; D006801:Humans; D007044:Hysterectomy; D016014:Linear Models; D008197:Lymph Node Excision; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D018570:Risk Assessment; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery