In vitro activity of PNU-100766 (linezolid), a new oxazolidinone antimicrobial, against Nocardia brasiliensis.
The in vitro activity of a novel oxazolidinone, linezolid, was studied by comparing the activity of linezolid with those of amikacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against 25 strains of Nocardia brasiliensis isolated from patients with mycetoma. All N. brasiliensis strains tested were sensitive to linezolid (MIC at which 90% of strains are inhibited [MIC(90)], 2 microg/ml; MIC(50), 1 microg/ml). This antimicrobial might constitute a good alternative for treatment of actinomycetoma.
Vera-Cabrera
L
L
Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatologia, Hospital Universitario, Monterrey, NL, México.
Gómez-Flores
A
A
Escalante-Fuentes
W G
WG
Welsh
O
O
D000081:Acetamides / Q000494:pharmacology*; D000583:Amikacin / Q000494:pharmacology; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003881:Dermatomycoses / Q000382:microbiology*; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects*; D009617:Nocardia Infections / Q000382:microbiology*; D023303:Oxazolidinones / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D019980:Amoxicillin-Potassium Clavulanate Combination; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000583:Amikacin; D000069349:Linezolid