Melatonin modulates allergic lung inflammation.
Asthma is an inflammatory lung disease characterized by cell migration, bronchoconstriction and hyperresponsiveness, and can be induced, as an experimental model, by ovalbumin sensitization followed by a challenge. In addition to the well-known immunostimulatory effects of melatonin, research has identified some of its anti-inflammatory properties. In this study, we evaluated the influence of pinealectomy and melatonin administration on cell migration in an experimental model of allergic airway inflammation. We evaluated, in pinealectomized rats treated or not with melatonin, cell migration into the bronchoalveolar fluid, the number of cells and their proliferative activity in the bone marrow, and plasma corticosterone levels. Pinealectomy reduces, 24 hr after the challenge, the total cell number count in the lung and bone marrow cell proliferation, without changing the number of cells in the bone marrow or in the peripheral blood. This fact suggests that melatonin is important in the control of cell recruitment from the bone marrow and the migration of those cells to the lung. Melatonin administration to pinealectomized rats seems to restore the ability of cells to migrate from the bone marrow to the bronchoalveolar fluid. So, the development of specific inhibitors of melatonin would benefit patients with asthma.
Martins
E
E
Department of Physiology and Biophysics, the Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900, São Paulo, SP, Brazil.
Ligeiro de Oliveira
A P
AP
Fialho de Araujo
A M
AM
Tavares de Lima
W
W
Cipolla-Neto
J
J
Costa Rosa
L F
LF
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid; D002465:Cell Movement / Q000187:drug effects; D003345:Corticosterone / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008550:Melatonin / Q000494:pharmacology / Q000502:physiology*; D010047:Ovalbumin / Q000494:pharmacology; D010870:Pineal Gland / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D012130:Respiratory Hypersensitivity / Q000503:physiopathology*
D007073:Immunoglobulin E; D010047:Ovalbumin; D008550:Melatonin; D003345:Corticosterone