Cyclin' round the cell with Rac.
New insight into how integrins stimulate cell cycle progression is provided by a recent paper showing that Rac is activated in endothelial cells plated on fibronectin, but not on laminin, and regulates translation of Cyclin D1 mRNA.
Ridley
A J
AJ
Ludwig Institute for Cancer Research, Royal Free and University College Medical School, London, United Kingdom.
D000818:Animals; D002453:Cell Cycle; D019938:Cyclin D1 / Q000378:metabolism; D004727:Endothelium / Q000166:cytology; D005353:Fibronectins / Q000378:metabolism; D007797:Laminin / Q000378:metabolism; D008954:Models, Biological; D010766:Phosphorylation; D011485:Protein Binding; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic; D020744:rac GTP-Binding Proteins / Q000378:metabolism* / Q000502:physiology*
D005353:Fibronectins; D007797:Laminin; D012333:RNA, Messenger; D019938:Cyclin D1; D020744:rac GTP-Binding Proteins