5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder.
Genetic factors, such as the genes involved in the serotonin pathway, probably play an important role in the pathogenesis of bipolar disorder, and serotonin type 2A (5-HT2A) receptor gene promoter polymorphism -1438A/G has been reported. This study investigated the association between -1438A/G polymorphism of 5-HT2A receptor gene promoter and bipolar disorder in a Korean population. Using the polymerase chain reaction, -1438A/G polymorphism typed in 142 patients with bipolar disorder and in 148 normal control subjects. Differences in genotype distributions and allele frequencies of -1438A/G between patients with bipolar disorder and normal control subjects were tested for significance using the chi-squared test. There were significant differences in genotype distributions [chi2 = 9.697, degrees of freedom (df) = 2, P = 0.008] and allele frequencies (chi2 = 7.284, df = 1, P = 0.007) of -1438A/G between patients with bipolar disorder and normal control subjects. Although further studies are necessary, these results in a Korean population suggest that -1438A/G polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder.
Chee
I S
IS
Department of Psychiatry, Chungnam National University Hospital, College of Medicine, Chungnam National University, Jung-Ku, Taejon, Korea. ischee@cnu.ac.kr
Lee
S W
SW
Kim
J L
JL
Wang
S K
SK
Shin
Y O
YO
Shin
S C
SC
Lee
Y H
YH
Hwang
H M
HM
Lim
M R
MR
D000225:Adenine; D000328:Adult; D044466:Asian People; D001714:Bipolar Disorder / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006147:Guanine; D006801:Humans; D007723:Korea; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D012016:Reference Values
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D006147:Guanine; D000225:Adenine