title: Second transplantation with CD34+ blood cells from an HLA-mismatched related donor after engraftment failure of transplanted cord blood cells.
abstract: Unrelated cord blood transplantation (CBT) has been worldwide for bone marrow reconstitution. CBT is associated with a high frequency of engraftment failure and rejection due to a small dose of graft cells. In cases of engraftment failure or rejection following unrelated CBT, retransplantation from the original donors is impossible. We report a successful transplantation with CD34+ blood cells selected from a 2-loci HLA-mismatched mother to a child with acute monocytic leukemia after engraftment failure of the primary CBT. Selected CD34+ blood cell transplantation is a useful approach for retransplantation in the setting of engraftment failure.
authors.affiliation: Department of Developmental Medicine, Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan. ohta@ped.med.osaka-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ohta
authors.forename: J Y
authors.initials: JY
authors.lastname: Kim
authors.forename: A
authors.initials: A
authors.lastname: Sawada
authors.forename: S
authors.initials: S
authors.lastname: Tokimasa
authors.forename: H
authors.initials: H
authors.lastname: Fujisaki
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Osugi
authors.forename: J
authors.initials: J
authors.lastname: Hara
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D001773:Blood Cells / Q000166:cytology / Q000276:immunology / Q000637:transplantation*; D018572:Disease-Free Survival; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D007231:Infant, Newborn; D007948:Leukemia, Monocytic, Acute / Q000628:therapy; D008297:Male
chemical_list: D018952:Antigens, CD34