title: A dynamic ion cooling technique for FTICR mass spectrometry.
abstract: A fast dynamic ion cooling technique based upon the adiabatic invariant phenomenon for Fourier transform ion cyclotron resonance mass spectrometry (FTICR) is presented. The method cools ions in the FTICR trap more efficiently, within a few hundred milliseconds without the use of a buffer gas, and results in a substantial signal enhancement. All performance aspects of the FTICR spectrum, e.g., peak intensities, mass resolution, and mass accuracy, improve significantly compared with cooling based on ion-ion interactions. The method may be useful in biological applications of FTICR, such as in proteomic studies involving extended on-line liquid chromatography (LC) separations, in which both the duty cycle and mass accuracy are crucially important.
authors.affiliation: Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: M V
authors.initials: MV
authors.lastname: Gorshkov
authors.forename: C D
authors.initials: CD
authors.lastname: Masselon
authors.forename: G A
authors.initials: GA
authors.lastname: Anderson
authors.forename: H R
authors.initials: HR
authors.lastname: Udseth
authors.forename: R
authors.initials: R
authors.lastname: Harkewicz
authors.forename: R D
authors.initials: RD
authors.lastname: Smith
mesh_terms: D000465:Algorithms; D002138:Calibration; D005583:Fourier Analysis; D013058:Mass Spectrometry / Q000295:instrumentation*; D009211:Myoglobin / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry
chemical_list: D009211:Myoglobin; D010455:Peptides; D011506:Proteins