title: A two-centre collaborative study on clinico-epidemiological profile of a recent outbreak of epidemic dropsy in New Delhi (India) with special emphasis on its cardiac manifestations in pediatric patients.
abstract: A hundred and six clinically diagnosed cases of epidemic dropsy, admitted in June to August 1998 to the P-III unit of RML Hospital and the Department of Pediatrics, Safdarjang Hospital, were studied. All of them consumed mustard oil contaminated with Argemona mexicana, confirmed by ferric chloride and nitric acid tests. No specific sex predilection was seen. No child was affected below the age of 3 years. Pedal edema and reddish hyperpigmentation were the most consistent findings (100 per cent). Frank cardiac failure was seen in only 24 (22.64 per cent), yet persistent tachycardia was alarmingly high (104/106, i.e. 98.4 per cent). Notably ECG showed prolonged Q-T interval in 24 children (22.64 per cent), unrelated to serum Ca2+ level in patients with congestive cardiac failure (CCF). Color Doppler echocardiography showed biventricular dilatation in all the 24 patients with CCF. Wide pulse pressure was recorded in two patients only. Mortality occurred in only two patients (1.89 per cent). Eye involvement was a late finding. All those who survived (i.e. 104/106) recovered completely, except two patients who were left with sarcoid-like changes of skin telangiectasia.
authors.affiliation: Department of Pediatrics, Safdarjang Hospital, New Delhi, India. aggarwal_kailash@hotmail.com
authors.forename: K C
authors.initials: KC
authors.lastname: Aggarwal
authors.forename: M S
authors.initials: MS
authors.lastname: Prasad
authors.forename: R N
authors.initials: RN
authors.lastname: Salhan
authors.forename: D
authors.initials: D
authors.lastname: Yadav
authors.forename: N
authors.initials: N
authors.lastname: Pandit
authors.forename: P C
authors.initials: PC
authors.lastname: Goyal
authors.forename: M
authors.initials: M
authors.lastname: Garg
mesh_terms: D004196:Disease Outbreaks; D004487:Edema / Q000139:chemically induced / Q000453:epidemiology*; D005260:Female; D005506:Food Contamination; D006331:Heart Diseases / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D009149:Mustard Plant; D010936:Plant Extracts / Q000009:adverse effects; D010938:Plant Oils / Q000009:adverse effects*
chemical_list: D010936:Plant Extracts; D010938:Plant Oils; C030610:argemone oil; C027793:mustard oil