title: Tetrachloroethylene in drinking water and birth outcomes at the US Marine Corps Base at Camp Lejeune, North Carolina.
abstract: A study of mean birth weight, small-for-gestational-age infants, and preterm birth was conducted at the US Marine Corps Base at Camp Lejeune, North Carolina, where drinking water was contaminated with volatile organic compounds. Tetrachloroethylene (PCE) was the predominant contaminant. The authors used multiple linear and logistic regression to analyze 1968-1985 data from 11,798 birth certificates. Overall, at most weak associations were observed between PCE exposure and study outcomes. However, associations were found between PCE exposure and birth-weight outcomes for infants of older mothers and mothers with histories of fetal loss. Adjusted mean birth-weight differences between PCE-exposed and unexposed infants were -130 g (90% confidence interval (CI): -236, -23) for mothers aged 35 years or older and -104 g (90% CI: -174, -34) for mothers with two or more previous fetal losses. Adjusted odds ratios for PCE exposure and small-for-gestational-age infants were 2.1 (90% CI: 0.9, 4.9) for older mothers and 2.5 (90% CI: 1.5, 4.3) for mothers with two or more prior fetal losses. These results suggest that some fetuses may be more vulnerable than others to chemical insult.
authors.affiliation: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA. nsonnenfeld@mailbox.une.edu
authors.forename: N
authors.initials: N
authors.lastname: Sonnenfeld
authors.forename: I
authors.initials: I
authors.lastname: Hertz-Picciotto
authors.forename: W E
authors.initials: WE
authors.lastname: Kaye
mesh_terms: D001719:Birth Certificates; D001724:Birth Weight / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D020073:Gravidity / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D016015:Logistic Models; D008423:Maternal Age; D018811:Maternal Exposure / Q000009:adverse effects / Q000706:statistics & numerical data; D008889:Military Personnel / Q000706:statistics & numerical data*; D009657:North Carolina / Q000453:epidemiology; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D016017:Odds Ratio; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies; D013750:Tetrachloroethylene / Q000009:adverse effects*; D014877:Water Pollution, Chemical / Q000009:adverse effects* / Q000706:statistics & numerical data*
chemical_list: D013750:Tetrachloroethylene