A genomic-systems biology map for cardiovascular function.
With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.
Stoll
M
M
Department of Physiology, Bioinformatics Research Center, and, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA.
Cowley
A W
AW
Tonellato
P J
PJ
Greene
A S
AS
Kaldunski
M L
ML
Roman
R J
RJ
Dumas
P
P
Schork
N J
NJ
Wang
Z
Z
Jacob
H J
HJ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D002874:Chromosome Mapping / Q000379:methods*; D002875:Chromosomes / Q000235:genetics; D003433:Crosses, Genetic; D005260:Female; D023281:Genomics / Q000379:methods*; D006801:Humans; D007668:Kidney / Q000502:physiology; D008126:Lod Score; D008297:Male; D019001:Nitric Oxide Synthase / Q000235:genetics; D009638:Norepinephrine / Q000494:pharmacology; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D051381:Rats; D014664:Vasodilation / Q000235:genetics
D019001:Nitric Oxide Synthase; D009638:Norepinephrine