Endometrial metastasis of cutaneous melanoma - A case-report bearing diagnostic difficulties -.
OBJECTIVE
To report a rare case of endometrial metastasis of cutaneous malignant melanoma, mimicked by histologically xanthomatous lesion. Only about ten other cases of endometrial metastasis of this malignancy have been reported previously. -


METHODS
Case report. -


METHODS
A 60 year old female. -


METHODS
Fractionated curettage and immunohistologically examination of the tissue. -


RESULTS
Due to xanthomatous regressive changes of the metastatic tissue, difficulties in the histological confirmation as a metastasis of an unpigmented malignant melanoma occurred. But immunohistological staining showed positivity for S-100 and MART-1, as did the primary tumour. -


CONCLUSIONS
If atypical bleeding in patients with known malignant melanoma of the skin occur endometrial metastasis should be excluded by gynaecologists.
Heinig
J
J
Department of Obstetrics and Gynaecology, University of Münster, Germany.
August
C
C
Beckmann
V
V
Konieczny
A
A
D000951:Antigens, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D004107:Dilatation and Curettage; D016889:Endometrial Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000556:secondary*; D004717:Endometrium / Q000737:chemistry / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen; D018328:Melanoma, Amelanotic / Q000150:complications / Q000175:diagnosis* / Q000556:secondary*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000473:pathology*; D014592:Uterine Hemorrhage / Q000209:etiology*
D000951:Antigens, Neoplasm; D058965:MART-1 Antigen; C548667:MLANA protein, human; D009363:Neoplasm Proteins; D009418:S100 Proteins