Apolipoprotein E and age at onset of Alzheimer's disease in African American patients.
The authors examined whether the APOE-epsilon4 allele is associated with an earlier age at onset of AD in 71 African American patients with probable AD. The authors found a linear dose effect in which each copy of the epsilon4 allele was associated with a 3.6-year earlier onset of AD, indicating a dose-dependent relationship between APOE-epsilon4 and age at onset of AD in African Americans.
Goldstein
F C
FC
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30329, USA. fgoldst@emory.edu
Ashley
A V
AV
Gearing
M
M
Hanfelt
J
J
Penix
L
L
Freedman
L J
LJ
Levey
A I
AI
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D005260:Female; D018628:Gene Dosage; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D001741:Black or African American
D053327:Apolipoprotein E4; D001057:Apolipoproteins E