The in vitro study of influence of four novel platinum compounds on rodent melanoma cells.
The purpose of this study was to assess cytotoxic effect of four new platinum compounds on B16 and CIS91 melanoma cells in vitro. The following complexes were tested: (2) Tetrachlorobis (5,7-dimethyl-1,2,4-triazol [1,5alpha] pirymidine) platinum (IV), (3) trans-dichloro (dimethylsulfoxide) (5,7-dimetyl-1,2,4-triazol-[1,5alpha] pirymidine) platinum(II), (4) cis-dichloro(dimethylsulfoxide)(1-beta-D-ribofuranosyl-1,2,4-triazol-3-carboxamide)platinum(II), (5) chloro(dimethylsulfoxide)(1-beta-D-ribofuranosyl-1,2,4-triazol-3-carboxamide)platinum(II). We can conclude, that Pt-dmtp (2) represented the best cytotoxic properties in the group of four tested platinum compounds, Pt-rib-1 (4) has also a good cytotoxic properties although its IC50 value is quite high. We suppose that cytotoxic and soluble properties ot Pt-dmtp and Pt-rib-1 could be modified and improved.
Drewa
T
T
Department of Human Biology, Ludwik Rydygier Medical University, Bydgoszcz, Poland.
Woźniak
A
A
Olszewska
D
D
Szłyk
E
E
Lakomska
I
I
Mila-Kierzenkowska
C
C
Czajkowski
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds