Stem cells: is there a future in plastics?
The concept that ostensibly tissue-specific stem cells can give rise to cells of heterologous lineages has gained support from studies using purified hematopoietic stem cells and sensitive donor-cell tracking methods. The ability to exploit these findings in clinical settings will probably depend on new insights into the mechanisms by which such stem cells or their progeny migrate to sites of organ damage and differentiate to cell types competent to participate in tissue regeneration.
Goodell
M A
MA
Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, BCM 505, One Baylor Plaza, Houston, TX 77030, USA. goodell@bcm.tmc.edu
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D005544:Forecasting; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology; D009474:Neurons / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*