Medical management of postoperative complications of inflammatory bowel disease: pouchitis and Crohn's disease recurrence.
Surgical intervention is often required for patients with inflammatory bowel disease. Total proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice for patients with ulcerative colitis. The main long-term complication of this surgery is pouchitis, with 10-year cumulative incidence rates between 24% and 46%. For patients with Crohn's disease, postoperative recurrence is a significant problem, with clinical recurrence rates as high as 55% at 5 years and 76% at 15 years. Increasing evidence suggests that postoperative medical therapy has the potential to decrease the risk of postoperative Crohn's disease recurrence.
Achkar
J P
JP
Department of Gastroenterology, The Cleveland Clinic Foundation, A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA. achkarj@ccf.org
Shen
B
B
D003424:Crohn Disease / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D015212:Inflammatory Bowel Diseases / Q000601:surgery*; D011183:Postoperative Complications; D019449:Pouchitis / Q000188:drug therapy*; D012008:Recurrence