Effect of N-acetylcysteine on colitis induced by acetic acid in rats.
(1) To verify the proposed role of reactive oxygen species (ROS) in ulcerative colitis, the effect of an antioxidant N-acetylcysteine (NAC) was studied in acetic acid (AA)-induced colonic inflammation. (2) Depending on the dose used, NAC administered intracolonically was found to reduce the extent of colonic damage, along with a decrease in myeloperoxidase (MPO) activity, colonic wet weight and wet/dry weight ratio. (3) NAC attenuated the enhanced vascular permeability and prevented the depletion of colonic reduced glutathione (GSH) caused by AA administration. (4) The findings indicate that NAC may prove beneficial in the treatment of colitis.
Nosál'ová
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Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, 842 16, Bratislava, Slovak Republic. exfanosv@savba.sk
Cerná
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Bauer
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D019342:Acetic Acid; D000111:Acetylcysteine / Q000627:therapeutic use*; D000818:Animals; D003092:Colitis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000032:analysis; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species
D017382:Reactive Oxygen Species; D009195:Peroxidase; D005978:Glutathione; D019342:Acetic Acid; D000111:Acetylcysteine