Chemical modification of chitosan: preparation and lectin binding properties of alpha-galactosyl-chitosan conjugates. Potential inhibitors in acute rejection following xenotransplantation.
Water-soluble alpha-galactosyl-chitosan conjugates were prepared by reductive amination of p-formylphenyl beta-melibioside on chitosan in good yield. Strong binding with phytohemagglutinin was demonstrated using Griffonia simplicifolia.
Sashiwa
H
H
Department of Chemistry, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5.
Thompson
J M
JM
Das
S K
SK
Shigemasa
Y
Y
Tripathy
S
S
Roy
R
R
D002240:Carbohydrate Sequence; D002686:Chitin / Q000031:analogs & derivatives / Q000737:chemistry*; D048271:Chitosan; D005690:Galactose / Q000031:analogs & derivatives* / Q000737:chemistry*; D006084:Graft Rejection / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D037102:Lectins / Q000737:chemistry*; D008969:Molecular Sequence Data; D037121:Plant Lectins; D014183:Transplantation, Heterologous / Q000276:immunology
C045475:Griffonia simplicifolia lectins; D007166:Immunosuppressive Agents; D037102:Lectins; D037121:Plant Lectins; D002686:Chitin; D048271:Chitosan; D005690:Galactose