title: Chemical modification of chitosan: preparation and lectin binding properties of alpha-galactosyl-chitosan conjugates. Potential inhibitors in acute rejection following xenotransplantation.
abstract: Water-soluble alpha-galactosyl-chitosan conjugates were prepared by reductive amination of p-formylphenyl beta-melibioside on chitosan in good yield. Strong binding with phytohemagglutinin was demonstrated using Griffonia simplicifolia.
authors.affiliation: Department of Chemistry, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5.
authors.forename: H
authors.initials: H
authors.lastname: Sashiwa
authors.forename: J M
authors.initials: JM
authors.lastname: Thompson
authors.forename: S K
authors.initials: SK
authors.lastname: Das
authors.forename: Y
authors.initials: Y
authors.lastname: Shigemasa
authors.forename: S
authors.initials: S
authors.lastname: Tripathy
authors.forename: R
authors.initials: R
authors.lastname: Roy
mesh_terms: D002240:Carbohydrate Sequence; D002686:Chitin / Q000031:analogs & derivatives / Q000737:chemistry*; D048271:Chitosan; D005690:Galactose / Q000031:analogs & derivatives* / Q000737:chemistry*; D006084:Graft Rejection / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D037102:Lectins / Q000737:chemistry*; D008969:Molecular Sequence Data; D037121:Plant Lectins; D014183:Transplantation, Heterologous / Q000276:immunology
chemical_list: C045475:Griffonia simplicifolia lectins; D007166:Immunosuppressive Agents; D037102:Lectins; D037121:Plant Lectins; D002686:Chitin; D048271:Chitosan; D005690:Galactose