title: Caffeine and stress: implications for risk, assessment, and management of hypertension.
abstract: Caffeine use is widespread, and its consumption increases during periods of stress. Caffeine raises blood pressure by elevating vascular resistance, and this effect is larger and more prolonged in hypertensive patients than in normotensive. The pressor response to caffeine occurs equally in persons at rest and under stress. The elevated baseline pressures of the hypertensive patient are therefore increased by both caffeine and stress, potentially leading to undesirably high pressures. Such combined effects on blood pressure may potentially confound the evaluation of hypertension, and possibly reduce the effectiveness of antihypertensive therapy. These effects are not abolished by pharmacologic tolerance to caffeine, as tolerance may not be complete with daily intake. The contribution of caffeine's effects to the development of hypertension warrants continued study, and caffeine use by patients merits consideration in terms of assessment and management of this disorder.
authors.affiliation: Veterans Affairs Medical Center, Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Hartley
authors.forename: W R
authors.initials: WR
authors.lastname: Lovallo
authors.forename: T L
authors.initials: TL
authors.lastname: Whitsett
authors.forename: B H
authors.initials: BH
authors.lastname: Sung
authors.forename: M F
authors.initials: MF
authors.lastname: Wilson
mesh_terms: D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002110:Caffeine / Q000494:pharmacology*; D005247:Feeding Behavior; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy; D008019:Life Style; D012307:Risk Factors; D013312:Stress, Physiological; D014481:United States / Q000453:epidemiology
chemical_list: D002110:Caffeine