Postantibiotic effects of antituberculosis agents alone and in combination.
The postantibiotic effects (PAEs) of seven antimycobacterial agents, tested at their respective peak concentrations in serum alone and in different combinations, against Mycobacterium tuberculosis ATCC 27294 were studied with a radiometric culture system in parallel with the viable count method. Rifampin gave the longest PAE (67.8 h) among the drugs used alone, and combinations of first-line drugs generally gave PAEs longer than 120 h. The data obtained might help provide a better understanding of the scientific basis of intermittently administered antituberculosis chemotherapy.
Chan
C Y
CY
Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. chiuychan@cuhk.edu.hk
Au-Yeang
C
C
Yew
W W
WW
Hui
M
M
Cheng
A F
AF
D000995:Antitubercular Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004347:Drug Interactions; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D009391:Nephelometry and Turbidimetry
D000995:Antitubercular Agents