[Recent trends of development of rapid-acting and long-acting human insulin analogues--its biological characteristics and clinical availability].
Modern diabetes therapy is positively introduced insulin administration including intensive insulin therapy to type 1 and type 2 diabetes to prevent or delay the development of long-term complications. However, conventional insulin derivatives could not mimic more closely physiological insulin secretion profiles, resulting in frequent hypoglycemia attacks and brittle diabetes. Recent advanced technologies have allowed to modify insulin molecules to obtain several insulin analogues. Lys.Pro insulin and insulin aspart, rapid-acting insulin analogues, have demonstrated improved post-prandial glucose control in comparison with regular insulin, even although they are usually administered immediately prior to the meal. Insulin glargine and SoLongln, long-acting insulin analogues, could preserve the stable basic insulin profiles during a day as compared with NPH insulin. These insulin analogues are very useful to supply the post-prandial and basic insulin secretions in type 1 and type 2 diabetics.
Yokono
K
K
Department of Internal and Geriatric Medicine, Kobe University, Graduate School of Medicine.
D000595:Amino Acid Sequence; D001786:Blood Glucose / Q000378:metabolism; D003692:Delayed-Action Preparations; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008969:Molecular Sequence Data; D019518:Postprandial Period
D001786:Blood Glucose; D003692:Delayed-Action Preparations; D007328:Insulin