Inhibition of bovine carbonic anhydrase by new sulfonamide compounds.
Inhibitory effects of three new derivatives of 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide on bovine carbonic anhydrase have been investigated. The new compounds are 2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide, 2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide, and 2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide. The new compounds inhibit the esterase activity of carbonic anhydrase noncompetitively and have inhibition constants and I(50) values very similar to those for 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, the latter being clinically used in the treatment of glaucoma.
Arslan
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Balikesir University Faculty of Science and Arts, Department of Chemistry, 10100 Balikesir, Turkey. oktay@jupiter.balikesir.edu.tr
D000086:Acetazolamide / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000187:drug effects; D002417:Cattle; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*; D013830:Thiadiazoles / Q000737:chemistry / Q000494:pharmacology
C448309:2-(2,2-dichloroacetylamino)-1,3,4-thiadiazole-5-sulfonamide; C448308:2-(3-chloropropionylamino)-1,3,4-thiadiazole-5-sulfonamide; C448310:2-(3-phenylpropionylamino)-1,3,4-thiadiazole-5-sulfonamide; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013830:Thiadiazoles; D002256:Carbonic Anhydrases; D000086:Acetazolamide