title: Dietary D-psicose, a C-3 epimer of D-fructose, suppresses the activity of hepatic lipogenic enzymes in rats.
abstract: D-Psicose (D-ribo-2-hexulose), a C-3 epimer of D-fructose, is present in small quantities in commercial carbohydrate complexes or agricultural products. Wistar male rats were fed experimental diets which consisted of 5% D-psicose, cellulose, D-fructose or D-glucose for 28 days. Abdominal adipose tissue weight was significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed a D-fructose and D-glucose diets, even though the four dietary groups were offered the same amount throughout the experimental period. Fatty acid synthase and glucose 6-phosphate dehydrogenase activities in the liver were significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed the D-fructose and D-glucose diets. However, lipoprotein lipase activities in the heart, soleus muscle and perirenal adipose tissue were the same. These results suggest that a supplement of D-psicose in the diet suppresses hepatic lipogenic enzyme activities. The lower abdominal fat accumulation in rats fed a D-psicose diet might result from lower lipogenesis in the liver.
authors.affiliation: Faculty of Agriculture, Kagawa University, Kita-gun, Japan. matsuo@ag.kagawa-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Matsuo
authors.forename: Y
authors.initials: Y
authors.lastname: Baba
authors.forename: M
authors.initials: M
authors.lastname: Hashiguchi
authors.forename: K
authors.initials: K
authors.lastname: Takeshita
authors.forename: K
authors.initials: K
authors.lastname: Izumori
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D064429:Fatty Acid Synthases / Q000378:metabolism*; D005632:Fructose / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: C003243:psicose; D005632:Fructose; D005954:Glucosephosphate Dehydrogenase; D064429:Fatty Acid Synthases; D005947:Glucose