Genome structure of Ebola virus subtype Reston: differences among Ebola subtypes. Brief report.
We determined the complete genome sequence of Ebola virus subtype Reston (EBO-R) in the Philippines in 1996. The deduced transcriptional signals were highly conserved among Ebola viruses except for the stop signal of L genes. The intergenic regions were composed of 4 to 7 nucleotides, and of 2 characteristic overlaps and a long intergenic region. The glycoprotein (GP) had several amino acid differences from EBO-R isolated in 1989 and 1992. The variety of GP sequences strongly suggests the independent introduction of EBO-R from unknown natural reservoirs in 1996.
Ikegami
T
T
Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
Calaor
A B
AB
Miranda
M E
ME
Niikura
M
M
Saijo
M
M
Kurane
I
I
Yoshikawa
Y
Y
Morikawa
S
S
D000595:Amino Acid Sequence; D000818:Animals; D029043:Ebolavirus / Q000145:classification / Q000235:genetics*; D016679:Genome, Viral; D006023:Glycoproteins / Q000737:chemistry; D000882:Haplorhini; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D012367:RNA, Viral / Q000737:chemistry; D014158:Transcription, Genetic; D014758:Viral Core Proteins / Q000235:genetics
D006023:Glycoproteins; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D012367:RNA, Viral; D014758:Viral Core Proteins