Vasculitis occurring during leflunomide therapy.
Leflunomide has recently been introduced for systemic treatment of rheumatoid arthritis. It has both immunosuppressive effects and anti-inflammatory properties. We report a patient treated with leflunomide who developed vasculitis as an adverse side effect. As far as we are aware, this is the first published report of vasculitis associated with leflunomide therapy.
Holm
E A
EA
Department of Medicine, Division of Dermatology, Roskilde Hospital, Denmark. eholm@dadlnet.dk
Balslev
E
E
Jemec
G B
GB
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007555:Isoxazoles / Q000009:adverse effects*; D000077339:Leflunomide; D008875:Middle Aged; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced*
D007166:Immunosuppressive Agents; D007555:Isoxazoles; D000077339:Leflunomide