Novel cytokine production inhibitors produced by a basidiomycete, Marasmiellus sp.
New cytokine production inhibitors, CJ-14,877 (I) and CJ-14,897 (II), were isolated from the fermentation broth of a basidiomycete, Marasmiellus sp. CL21624. Their structures were determined to be methyl-(7S,8S)-5-(7,8-dihydroxypropyl)pyridine-2-carboxylate and methyl-(7S,8S)-5-(8-acetoxy-7-hydroxypropyl)pyridine-2-carboxylate [corrected], respectively, by spectroscopic analyses. These compounds showed inhibitory activities for lipopolysaccharide-induced production of interleukin-1beta and tumor necrosis factor-alpha in human whole blood with IC50 values of the range from 0.059 to 2.6 microM.
Ichikawa
K
K
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc., Chita-gun, Aichi, Japan. katsuomi.ichikawa@japan.pfizer.com
Hirai
H
H
Ishiguro
M
M
Kambara
T
T
Kato
Y
Y
Kim
Y J
YJ
Kojima
Y
Y
Matsunaga
Y
Y
Nishida
H
H
Shiomi
Y
Y
Yoshikawa
N
N
Kojima
N
N
D000363:Agaricales / Q000254:growth & development / Q000378:metabolism*; D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D020128:Inhibitory Concentration 50; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood; D010848:Picolinic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D002264:Carboxylic Acids; D016207:Cytokines; D007375:Interleukin-1; D010848:Picolinic Acids; D011725:Pyridines; D014409:Tumor Necrosis Factor-alpha; C440625:methyl 5-(7,8-dihydroxypropyl)pyridine-2-carboxylate; C440626:methyl 5-(8-acetoxy-7-hydroxypropyl)pyridine-2-carboxylate