title: Aldose reductase inhibitors from the fruits of Caesalpinia ferrea Mart.
abstract: Aldose reductase inhibitors were isolated from an extract of the dry fruits of Caesalpinia ferrea Mart. (Leguminosae). Compound 2 was identified as ellagic acid by comparison with a reference sample. The structure of compound 1 was elucidated as 2-(2,3,6-trihydroxy-4-carboxyphenyl) ellagic acid on the basis of spectral evidence, especially 2D-NMR data (HMQC, HMBC and NOESY). These two compounds inhibited aldose reductase in a non-competitive manner.
authors.affiliation: Kobe Pharmaceutical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Tachibana
authors.forename: M
authors.initials: M
authors.lastname: Moriyasu
authors.forename: K
authors.initials: K
authors.lastname: Kawanishi
authors.forename: S M
authors.initials: SM
authors.lastname: Alves
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D029911:Caesalpinia; D004610:Ellagic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000494:pharmacology*; D012015:Reference Standards
chemical_list: C451101:2-(2,3,6-trihydroxy-4-carboxyphenyl) ellagic acid; D010936:Plant Extracts; D004610:Ellagic Acid; D000449:Aldehyde Reductase