Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.
Integrin-mediated cell adhesions provide dynamic, bidirectional links between the extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and morphogenesis, focal adhesions and related structures convey information across the cell membrane, to regulate extracellular-matrix assembly, cell proliferation, differentiation, and death. This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.
Geiger
B
B
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. benny.geiger@weizmann.ac.il
Bershadsky
A
A
Pankov
R
R
Yamada
K M
KM
D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism* / Q000502:physiology*; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism* / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D010766:Phosphorylation; D011485:Protein Binding; D015398:Signal Transduction