title: Multisite, double-blind, placebo-controlled trial of porcine secretin in autism.
abstract: OBJECTIVE
  To examine the efficacy of intravenous porcine secretin for the treatment of autistic disorder.
  
  
  METHODS
  Randomized, double-blind, placebo-controlled, crossover design. Fifty-six subjects with autistic disorder received either a secretin or placebo infusion at baseline and the other substance at week 4. Subjects were given the Autism Diagnostic Observation Schedule (ADOS) and other pertinent developmental measures at baseline and at weeks 4 and 8 to assess drug effects.
  
  
  RESULTS
  For the primary efficacy analysis, change of ADOS social-communication total score from week 0 to week 4, no statistically significant difference was obtained between placebo (-0.8 +/- 2.9) and secretin groups (-0.6 +/- 1.4; t54 = 0.346, p < .73). The other measures showed no treatment effect for secretin compared with placebo.
  
  
  CONCLUSIONS
  There was no evidence for efficacy of secretin in this randomized, placebo-controlled, double-blind trial.
authors.affiliation: Department of Psychiatry, University of Chicago, IL 60637, USA. towley@yoda.bsd.uchicago.edu
authors.forename: T
authors.initials: T
authors.lastname: Owley
authors.forename: W
authors.initials: W
authors.lastname: McMahon
authors.forename: E H
authors.initials: EH
authors.lastname: Cook
authors.forename: T
authors.initials: T
authors.lastname: Laulhere
authors.forename: M
authors.initials: M
authors.lastname: South
authors.forename: L Z
authors.initials: LZ
authors.lastname: Mays
authors.forename: E S
authors.initials: ES
authors.lastname: Shernoff
authors.forename: J
authors.initials: J
authors.lastname: Lainhart
authors.forename: C B
authors.initials: CB
authors.lastname: Modahl
authors.forename: C
authors.initials: C
authors.lastname: Corsello
authors.forename: S
authors.initials: S
authors.lastname: Ozonoff
authors.forename: S
authors.initials: S
authors.lastname: Risi
authors.forename: C
authors.initials: C
authors.lastname: Lord
authors.forename: B L
authors.initials: BL
authors.lastname: Leventhal
authors.forename: P A
authors.initials: PA
authors.lastname: Filipek
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D010552:Personality Assessment; D012633:Secretin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D012633:Secretin