title: Fulminant hepatic failure secondary to adenovirus following fludarabine-based chemotherapy for non-Hodgkin's lymphoma.
abstract: Self-limited adenoviral infections are very common with the majority of infections resolving rapidly. Fatal complications may occur in severely immunocompromised patients. We describe a case of fulminant hepatic failure due to adenovirus in a 54-year-old man treated with fludarabine and cyclophosphamide for non-Hodgkin's lymphoma. There are no previous reports of this complication in conjunction with purine nucleoside therapy.
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Hogan
authors.forename: W D
authors.initials: WD
authors.lastname: Edwards
authors.forename: W R
authors.initials: WR
authors.lastname: Macon
authors.forename: T M
authors.initials: TM
authors.lastname: Habermann
mesh_terms: D000257:Adenoviridae Infections / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001344:Autopsy; D017809:Fatal Outcome; D006801:Humans; D017093:Liver Failure / Q000209:etiology* / Q000473:pathology / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity*
chemical_list: D014740:Vidarabine; C024352:fludarabine