Effects of Mullerian anomalies on in vitro fertilization outcome.
OBJECTIVE
To assess the effect of Mullerian anomalies on pregnancy rates in women undergoing in vitro fertilization (IVF).


METHODS
The records of 37 patients with and 819 patients without Mullerian anomalies undergoing a first cycle of IVF between December 1995 and July 1998 were included in this retrospective study. Outcome variables included maximal estradiol level, number of days of stimulation, number of follicles, number of oocytes, fertilization rate, and ongoing/livebirth pregnancy rate.


RESULTS
Patients with Mullerian anomalies had a significantly lower ongoing pregnancy rate (8.3%) than did controls (24.8%). No patients with diethylstilbestrol (DES)-related anomalies had an ongoing pregnancy.


CONCLUSIONS
Among women with Mullerian anomalies, those with DES exposure in utero demonstrated the poorest outcome.
Attia
K I
KI
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Hug-Koronya
M
M
Ginsburg
E S
ES
Hornstein
M D
MD
D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D009095:Mullerian Ducts / Q000002:abnormalities* / Q000473:pathology; D009865:Oocytes / Q000502:physiology; D006080:Ovarian Follicle / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies
D004958:Estradiol; D004054:Diethylstilbestrol