title: 10-Demethoxystegane, a new lignan from Steganotaenia araliacea.
abstract: A new dibenzocyclooctadiene lactone lignan, 10-demethoxystegane (1), together with the known compounds steganone (2) and prestegane B (3), have been isolated from the organic extract of Steganotaenia araliacea(Apiaceae). Steganone (2) showed antiproliferative activity against an ovarian cancer cell line (OVCAR-3).
authors.affiliation: Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Meragelman
authors.forename: T C
authors.initials: TC
authors.lastname: McKee
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms; D010946:Plants, Medicinal / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: C442623:10-demethoxystegane; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; C442624:steganone; C053360:prestegane B; D015107:4-Butyrolactone