Outpatient inhaled nitric oxide in a patient with idiopathic pulmonary fibrosis: a bridge to lung transplantation.
Inhaled nitric oxide (INO) has been shown to improve oxygenation and decrease intrapulmonary shunt and pulmonary hypertension in various lung diseases. In this study we report a patient with end-stage idiopathic pulmonary fibrosis and pulmonary hypertension who received INO after coronary artery bypass surgery, with significant improvement in arterial oxygenation and pulmonary arterial pressure. Using a pulsing delivery system, the patient continued to receive outpatient INO for 30 months while waiting for lung transplantation. Exercise study and two-dimensional echocardiogram, after 3 months of inhaled NO, demonstrated continued benefits of INO for improvement of arterial oxygenation, pulmonary arterial pressure and exercise tolerance.
Yung
G L
GL
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Diego School of Medicine, San Diego, California 92103-8373, USA. gyung@ucsd.edu
Kriett
J M
JM
Jamieson
S W
SW
Johnson
F W
FW
Newhart
J
J
Kinninger
K
K
Channick
R N
RN
D000280:Administration, Inhalation; D000553:Ambulatory Care; D001026:Coronary Artery Bypass; D006801:Humans; D006976:Hypertension, Pulmonary / Q000628:therapy; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000008:administration & dosage*; D011183:Postoperative Complications; D011658:Pulmonary Fibrosis / Q000628:therapy*
D009569:Nitric Oxide