Effect of tumor necrosis factor-alpha on skeletal muscle metabolism.
Over the past year, considerable progress has been made in our understanding of biologic actions by which tumor necrosis factor-alpha (TNF-alpha) may influence skeletal muscle metabolism. Reports published during this period highlighted three general actions with metabolic consequences: accelerated catabolism (protein loss, insulin resistance), contractile dysfunction, and disruption of myogenesis. Recent research also indicates that skeletal muscle myocytes synthesize TNF-alpha and that the cytokine functions as an endogenous mediator of muscle adaptation via autocrine/paracrine effects. These advances demonstrate the fundamental importance of TNF-alpha effects on skeletal muscle myocytes and provide a focus for future studies of intracellular mechanism.
Li
Y P
YP
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Reid
M B
MB
D000818:Animals; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha