[Changes in the immune status parameters and their correction in various forms of tick-borne encephalitis].
Comparative investigation of immune status indices in patients with fever form of vernal encephalitis (group 1), with inapparent form with prolonged antigenemia (group III) and with short-term antigenemia (group II) was performed for the first time. Total 99 patients were under investigation. It was shown that in group I selective damage of immune system at T-level took place. In patients of group III immune system at all levels was less involved and humoral factor were changes. In patients in group II no significant change in immune system were registered. Activity of different immune correctors (thimalin, 4-iodoantipirine, leukinferon) was investigated in vitro. This preparations had stimulating effect in blood samples of patients with decreased immune status. In the patients with unchanged immune status no effect was demonstrated. The most prominent effect was revealed in the case of 4-iodoantipirine--interferon inducer.
Krylova
N V
NV
Research Institute of Epidemiology and Microbiology, Siberian Branch of the Russian Academy of Medical Sciences, Vladivostok.
Iakusheva
S S
SS
Borisevich
V G
VG
Leonova
G N
GN
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016207:Cytokines / Q000627:therapeutic use; D004338:Drug Combinations; D004675:Encephalitis, Tick-Borne / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007369:Interferon Inducers / Q000627:therapeutic use*; D007370:Interferon Type I / Q000627:therapeutic use; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D013951:Thymus Hormones / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D016207:Cytokines; D004338:Drug Combinations; D007369:Interferon Inducers; D007370:Interferon Type I; D011971:Receptors, Immunologic; D013951:Thymus Hormones; C062252:leukinferon; C032805:thymalin; D000983:Antipyrine; C008135:iodoantipyrine