title: A temporary phosphorus tether/ring-closing metathesis strategy to functionalized 1,4-diamines.
abstract: The synthesis of 1,4-diamines containing the (Z)-1,4-diaminobut-2-ene subunit via a temporary phosphorus tether/RCM strategy is described. We have developed a new method utilizing phosphorus nuclei as suitable temporary tethers for the coupling of nonracemic allylic amines. This approach allows for the generation of C(2)-symmetric and unsymmetric 1,4-diamines 1-3, which may have considerable synthetic and biological utility. This represents the first synthetic pathway for the expedient coupling of two amines via a temporary tether approach. [structure: see text]
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA.
authors.forename: K T
authors.initials: KT
authors.lastname: Sprott
authors.forename: M D
authors.initials: MD
authors.lastname: McReynolds
authors.forename: P R
authors.initials: PR
authors.lastname: Hanson
mesh_terms: D003959:Diamines / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry*
chemical_list: D003959:Diamines; D010758:Phosphorus