title: Challenges in functional bowel disease.
abstract: Society, the workplace and the family are changing. Despite increasing wealth, these changes appear to be accompanied by increasing anxiety and depression. Functional bowel disorders are associated with increased psychological morbidity, and the treatment of functional disorders needs to take these social and psychological factors into account. In the medical setting, therefore, the "therapeutic team" needs to be restructured to encompass a broader spectrum of skills and resources than currently exists in most units. An increase in understanding of pathophysiological mechanisms is likely to be helpful for patients who are not amenable to, or have failed, first line psychologically based, or simple drug, therapies. For example, in reflux disease, the elucidation of the mechanism underlying spontaneous sphincter relaxations may lead to precise end organ targeting-this can be at efferent or afferent ends of the pathways. Recent elucidation of involvement of GABA and NO have highlighted possible neurochemical targets. In constipation 5-HT4 agonists have lead to specific activation of motor events responsible for gut transport. For diarrhoea, multiple targets are available. e.g. opioid agonists, somatostatin analogues. Modulation of pain represents a more difficult task. Decreasing visceral sensitivity, and alteration of cerebral or spinal mediation of pain, remain unproven strategies. Greater understanding of the mechanisms by which chronic stress influence gut function and symptoms is likely to lead to new therapeutic approaches. This should include an understanding of the link between psychological morbidity and altered autonomic effector function. It should help in understanding why symptoms localise to different body systems, such as the gut or gynaecological viscera. Other priorities in this area are to improve clinical trial design, and to improve symptom and quality of life measures of the efficacy of treatments.
authors.affiliation: Physiology Unit, St Mark's Hospital, London, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Kamm
mesh_terms: D003109:Colonic Diseases, Functional / Q000523:psychology* / Q000628:therapy; D006801:Humans; D012959:Socioeconomic Factors