Comparative effects of losartan and captopril on ventricular remodeling and function after myocardial infarction in the rat.
OBJECTIVE
To determine the effects of losartan and captopril treatment on ventricular remodeling and function after myocardial infarction in rats.


METHODS
Thirty-two rats with MI induced by coronary ligation after seven days were divided into four groups randomly and treated with captopril(2 g.liter-1, group A), losartan(10 mg.kg-1.d-1, group B), losartan(30 mg.kg-1.d-1, group C) and placebo (no drug, group D) for six weeks, respectively. Sham-operated rats(group E) served as controls. Echocardiography was performed at 1 and 7 weeks after MI, respectively.


RESULTS
Compared with the results before treatment, both LV end-diastolic internal diameter and volume decreased significantly and the thickened posterior wall was reversed in group A, B and C; the peak early filling velocity decreased whereas the peak velocity was increased in these three groups. There are no significant difference among the three treated groups. However, LV end-diastolic internal diameter and the E/A were still increased, whereas the thickness of anterior wall and the peak velocity of LV outflow were decreased in group A, B, and C after treatment comparing with group E.


CONCLUSIONS
Both angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist can prevent the ventricular remodeling and improve the ventricular function.
Zhang
G
G
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical University, Shanghai 200032.
Shen
X
X
Pu
S
S
Yang
Y
Y
Pan
W
W
Chen
H
H
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D006334:Heart Function Tests; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D044140:Receptor, Angiotensin, Type 1; D014463:Ultrasonography; D020257:Ventricular Remodeling / Q000187:drug effects*
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D044140:Receptor, Angiotensin, Type 1; D002216:Captopril; D019808:Losartan