Seminal toxicity of nickel sulfate in mice.
Young male albino mice of Swiss strain were exposed to nickel by oral route of 20 mg nickel sulfate/kg body weight for 5 d/wk for 6 mo. A decrease in normal (testosterone-dependent) proteinuria was shown, and morphological examination of the seminal vesicles revealed a lower weight and smaller size as well as a histological indication of lower secretory activity of the epithelium compared to controls. The findings are consistent with a theory implying a decreased testosterone activity in nickel-treated animals.
Pandey
R
R
Department of Zoology, Lucknow University, India.
Singh
S P
SP
D000818:Animals; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009532:Nickel / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D012669:Seminal Vesicles / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D013739:Testosterone / Q000502:physiology
D013739:Testosterone; C029938:nickel sulfate; D009532:Nickel