title: [Cardiovascular effects of colforsin daropate hydrochloride for acute heart failure after open heart surgery].
abstract: Colforsin daropate hydrochloride (COL) is a novel drug for the treatment of acute heart failure. COL stimulates adenylate cyclase directly and produces positive inotropic and vasodilator effects accompanied by the increase in cellular cAMP. We investigated its cardiovascular effects for 9 patients who showed low cardiac index (< 3.0 l/min/m2) after open-heart surgery in ICU. After 2 or 3 hours from administration of COL, heart rate and cardiac index increased, and pulmonary artery pressure and central venous pressure decreased significantly, but blood pressure and systemic venous oxygen saturation did not show significant change. In conclusion, COL improved hemodynamics through positive inotropic and vasodilator effects without hypotension. We should investigate more proper usage of this drug to avoid such side effects as tachycardia and arrhythmia, which occurred in some cases.
authors.affiliation: Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hibino
authors.forename: A
authors.initials: A
authors.lastname: Kawai
authors.forename: S
authors.initials: S
authors.lastname: Uchikawa
authors.forename: G
authors.initials: G
authors.lastname: Chikazawa
authors.forename: T
authors.initials: T
authors.lastname: Kurihara
authors.forename: S
authors.initials: S
authors.lastname: Kihara
authors.forename: K
authors.initials: K
authors.lastname: Uebe
authors.forename: S
authors.initials: S
authors.lastname: Aomi
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: M
authors.initials: M
authors.lastname: Endo
authors.forename: H
authors.initials: H
authors.lastname: Koyanagi
mesh_terms: D000208:Acute Disease; D000262:Adenylyl Cyclases / Q000378:metabolism; D006348:Cardiac Surgical Procedures; D005576:Colforsin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D011183:Postoperative Complications / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; C122001:colforsin daropate; D005576:Colforsin; D000262:Adenylyl Cyclases