Checkpoints: chromosome pairing takes an unexpected twist.
When meiotic cells complete S phase, homologous chromosomes pair, synapse and undergo recombination. A checkpoint protein is somehow required for meiotic chromosome pairing in C. elegans, thus providing a direct link between S phase and the rest of the meiotic program.
Meier
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B
Department of Genetics, Coker Hall, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA. bettina_meier@unc.med.edu
Ahmed
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S
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology*; D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D064447:Checkpoint Kinase 2; D023902:Chromosome Pairing; D004249:DNA Damage; D004261:DNA Replication; D008540:Meiosis; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins
D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases; D064447:Checkpoint Kinase 2; C444421:CHK-2 protein, C elegans; D017346:Protein Serine-Threonine Kinases; C067022:RAD53 protein, S cerevisiae