[1,3;1,6-beta-D-glucan translam: results of studying and prospects for application].
The results of translam chemical structure and biological activity investigation are presented. Translam is a new original semisynthetic polysaccharide of marine origin. The preparation demonstrated potent treatment effect in experimental radiation disease. It had preventing effect at experimental bacterial infections, stimulated hematopoiesis, had effect on humoral and cell immunity and on factors of nonspecific organism resistance.
Ivanushko
L A
LA
Research Institute of Epidemiology and Microbiology, Siberian Branch of the Russian Academy of Medical Sciences, Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok.
Besednova
N N
NN
Zaporozhets
T S
TS
Zviagintseva
T N
TN
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D002478:Cells, Cultured; D004285:Dogs; D004927:Escherichia coli Infections / Q000401:mortality / Q000517:prevention & control; D005936:Glucans / Q000494:pharmacology*; D006168:Guinea Pigs; D006410:Hematopoiesis / Q000187:drug effects; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D015012:Yersinia pseudotuberculosis Infections / Q000401:mortality / Q000517:prevention & control
D000276:Adjuvants, Immunologic; D005936:Glucans; C033671:epiglucan