Viral-based gene transfer to the mammalian CNS for functional genomic studies.
A fundamental problem in neuroscience has been the creation of suitable in vivo model systems to study basic neurological phenomena and pathology of the central nervous system (CNS). Somatic cell genetic engineering with viral vectors provides a versatile tool to model normal brain physiology and a variety of neurological diseases.
Janson
C G
CG
CNG Gene Therapy Center, Jefferson Medical College, 1025 Walnut Street, Suite 511, Philadelphia, PA 19107, USA. cjanson@hotmail.com
McPhee
S W
SW
Leone
P
P
Freese
A
A
During
M J
MJ
D000818:Animals; D001921:Brain / Q000502:physiology*; D001927:Brain Diseases / Q000503:physiopathology; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D008322:Mammals; D014780:Viruses / Q000235:genetics*