Preventing recurrent second trimester group B streptococcus chorioamnionitis by intermittent prophylactic ampicillin.
BACKGROUND
Whereas carrying group B streptococcus during pregnancy is common, second trimester group B streptococcus chorioamnionitis with intact membranes is rare, and recurrence of the latter problem even more so.


METHODS
A 38-year-old multipara with a history of recurrent second trimester group B streptococcus chorioamnionitis resulting in pregnancy loss was treated, beginning at 14 weeks' gestation, with monthly prophylactic ampicillin therapy throughout pregnancy and delivered a healthy male infant at term.


CONCLUSIONS
In women with recurrent pregnancy loss due to second trimester group B streptococcus chorioamnionitis, an intermittent prophylactic antibiotic regimen throughout pregnancy might increase the probability of successful pregnancy.
Marinoff
D N
DN
Department of Obstetrics and Gynecology, Alta Bates Medical Center, Berkeley, California, USA.
Chinn
A
A
D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002821:Chorioamnionitis / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000517:prevention & control*; D011262:Pregnancy Trimester, Second; D012008:Recurrence; D013290:Streptococcal Infections / Q000517:prevention & control*; D013292:Streptococcus agalactiae
D010406:Penicillins; D000667:Ampicillin