title: Improvement in insulin sensitivity followed by ovulation and pregnancy in a woman with polycystic ovary syndrome who was treated with rosiglitazone.
abstract: OBJECTIVE
  To determine the metabolic and reproductive effectiveness of rosiglitazone in polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Case report.
  
  
  METHODS
  Academic clinical practice and General Clinical Research Center.
  
  
  METHODS
  A 25-year-old woman with PCOS.
  
  
  METHODS
  Rosiglitazone maleate, 4 mg daily for 5 months until conception.
  
  
  METHODS
  Insulin sensitivity by steady-state plasma glucose technique; serum androgens, progesterone, and hCG; and pelvic ultrasound images.
  
  
  RESULTS
  Rosiglitazone treatment for 5 months improved insulin sensitivity, lowered serum free testosterone, and resulted in spontaneous ovulation and conception.
  
  
  CONCLUSIONS
  Rosiglitazone is a promising insulin sensitizer for treatment of PCOS. Clinical trials are warranted.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305-5317, USA. ncataldo@stanford.edu
authors.forename: N A
authors.initials: NA
authors.lastname: Cataldo
authors.forename: F
authors.initials: F
authors.lastname: Abbasi
authors.forename: T L
authors.initials: TL
authors.lastname: McLaughlin
authors.forename: C
authors.initials: C
authors.lastname: Lamendola
authors.forename: G M
authors.initials: GM
authors.lastname: Reaven
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000502:physiology*; D010060:Ovulation; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology*; D011247:Pregnancy; D000077154:Rosiglitazone; D013844:Thiazoles / Q000627:therapeutic use*; D045162:Thiazolidinediones
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D013844:Thiazoles; D045162:Thiazolidinediones; D000077154:Rosiglitazone