In vitro hepatic biotransformation of aldrin and dieldrin in food-producing animals.
The hepatic biotransformation of aldrin (AD) and dieldrin (DD) was studied in liver post-mitochondrial supernatants (S-9s) from laying hens, female cattle and swine. S-9s were incubated with 0.03 nmol of AD or DD for 1 h. After 1 h, AD in the samples was almost epoxidated to DD. This formation was found with all the animal S-9s, and the highest rates occurred in pig S-9 (P < 0.01), followed by cow and hen S-9s. No reduction of DD was found with any of the S-9s.
Furusawa
N
N
Faculty of Human Life Science, Osaka City University, Osaka 558-8585, Japan. furusawa@life.osaka-cu.ac.jp
Morita
Y
Y
D000452:Aldrin / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D002417:Cattle; D002645:Chickens; D004026:Dieldrin / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D007306:Insecticides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D013552:Swine; D013997:Time Factors
D007306:Insecticides; D004026:Dieldrin; D000452:Aldrin