title: Hemostasis in children with dysbacteriosis in chronic constipation.
abstract: The purpose of the study was to investigate hemostasis in children with dysbacteriosis disturbance in chronic constipation. The disturbance of factors in the inner mechanism of blood coagulation (VII, IX, XI, XII) in compensated chronic constipation was defined based on the reduction in colon bacillus levels. We observed hypocoagulation caused by the reduced activity of the prothrombin complex factors, disaggregate thrombocytopathy, and endotheliosis with fibrinolysis inhibition in subcompensated chronic colostasis with continuous reduction of colon bacillus levels and pathogenic microflora appearance. In decompensated colostasis there was an increase in pathogenic microorganisms and a continuous reduction of colon bacillus levels. In hemostasis there was a factor deficiency in inner (XII, XI, IX, VIII) and outer (II, V, VII, X) blood coagulation mechanisms. Fibrinolysis inhibition, endotheliosis development with thrombocyte aggregation, and microthrombosis formation were determined. Thus, in children with chronic constipation, there was a marked reduction in the amount of colon bacillus, which led to the reproduction of pathogenic bacteria. We also observed chronometric hypocoagulation with the inner (XII, XI, IX, VIII) and outer (II, V, VII, X) mechanisms of blood coagulation, at the base of which there is the deficiency of vitamin K-dependent factors (II, VII, IX, X) and a slightly marked disturbance in the final stage of coagulation. In thrombocyte vascular hemostasis, thrombocytopathy was observed with increased adenosine-5-diphosphate aggregation and the inhibition of the inner mechanism with fibrinolysis and endotheliosis.
authors.affiliation: Krasnoyarsk State Medical Academy, The City's Clinical Hospital No. 20, The Department of Children Surgery of the Advanced Medical Courses, Russia. kirgizov@online.ru
authors.forename: I V
authors.initials: IV
authors.lastname: Kirgizov
authors.forename: A M
authors.initials: AM
authors.lastname: Sukhorukov
authors.forename: V A
authors.initials: VA
authors.lastname: Dudarev
authors.forename: A A
authors.initials: AA
authors.lastname: Istomin
mesh_terms: D000293:Adolescent; D001407:Bacillus / Q000254:growth & development; D001419:Bacteria / Q000145:classification / Q000254:growth & development / Q000472:pathogenicity; D001779:Blood Coagulation Factors / Q000378:metabolism; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000382:microbiology / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003106:Colon / Q000382:microbiology*; D003248:Constipation / Q000097:blood* / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D006487:Hemostasis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010974:Platelet Aggregation
chemical_list: D001779:Blood Coagulation Factors