title: Design of a trial evaluating myocardial cell protection with cariporide, an inhibitor of the transmembrane sodium-hydrogen exchanger: the Guard During Ischemia Against Necrosis (GUARDIAN) trial.
abstract: Inhibition of the sodium-hydrogen exchanger (NHE) is a powerful experimental tool to inhibit sodium and calcium accumulation within the ischemic myocyte and halt progression of cell ischemia to cell necrosis. This paper describes the protocol and rationale of a first large-scale clinical trial designed to evaluate the safety and efficacy of cariporide, a novel specific and potent inhibitor of the exchanger.
authors.affiliation: University of Montreal and Montreal Heart Institute, Montreal, Canada. theroux@ICUM.Umontreal.CA
authors.forename: Pierre
authors.initials: P
authors.lastname: Theroux
authors.forename: Bernard R
authors.initials: BR
authors.lastname: Chaitman
authors.forename: Leif
authors.initials: L
authors.lastname: Erhardt
authors.forename: Andreas
authors.initials: A
authors.lastname: Jessel
authors.forename: Thomas
authors.initials: T
authors.lastname: Meinertz
authors.forename: Wolf-Ulrich
authors.initials: WU
authors.lastname: Nickel
authors.forename: John S
authors.initials: JS
authors.lastname: Schroeder
authors.forename: Gianni
authors.initials: G
authors.lastname: Tognoni
authors.forename: Harvey
authors.initials: H
authors.lastname: White
authors.forename: James T
authors.initials: JT
authors.lastname: Willerson