[Association between ischemic heart disease and peptic ulcer. A case-control study].
OBJECTIVE
To determine whether patients with ischemic heart disease (IHD) are at higher risk for peptic ulcer (PU).


METHODS
We performed a case-control study. The patients were selected by simple random sampling of clinical histories.


METHODS
310 patients with IHD (angina pectoris, myocardial infarct or both).


METHODS
310 patients without IHD, paired by age, sex and tobacco consumption. Data were obtained by review of the patients' clinical histories. Response variable: diagnosis of peptic ulcer by endoscopy, esophagogastroduodenal transit or surgery. The odds ratio (OR) was determined by logistic regression, adjusting for the effect of confounding variables and risk for PU.


RESULTS
The mean age of the patients was 72.7 years (SD 8.6) and 70% were men. PU was found in 18.7% of the patients and in 12.3% of the controls with an adjusted OR of 1.77 (95% CI: 1.12-2.77; p = 0.01). This effect was produced at the expense of duodenal ulcer with an adjusted OR of 2.22 (95% CI: 1.29-3.74; p = 0.003). The adjusted OR of gastric ulcer was 1.13 (95% CI: 0.45-2.82; p = 0.8).


CONCLUSIONS
After adjusting for the effect of confounding variables and risk factors for the development of PU, this disease was more frequent in the group of patients with IHD.
Baena Díez
J
J
Area Básica de Salud, Barcelona, Spain. jbaenad@meditex.es
López Gosp
D
D
De La Poza Abad
M
M
Raidó Quintana
E
E
Vila Capdevila
M
M
Martínez Martínez
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000150:complications; D016022:Case-Control Studies; D004381:Duodenal Ulcer / Q000150:complications*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D017202:Myocardial Ischemia / Q000150:complications*; D016017:Odds Ratio; D013276:Stomach Ulcer / Q000150:complications*