title: Management of pregnancy with congenital antithrombin III deficiency: two case reports and a review of the literature.
abstract: Women with antithrombin (AT) III deficiency are prone to pregnancy-associated venous thromboembolism. We report 2 cases with genetically confirmed ATIII deficiency, one with a mutation in exon 3A and the other with an exon 4 deletion, in whom the pregnancies were successfully managed with prophylactic therapies for thrombosis. A 35-year-old pregnant woman was treated with intravenous infusions of ATIII concentrate alone, and the other 22-year-old pregnant woman was mainly treated with subcutaneous injections of heparin and oral low-dose aspirin therapy. Both pregnancies resulted in vaginal deliveries of healthy neonates. The literature concerning prophylactic therapies for thrombosis in ATIII deficiency-complicated pregnancy is reviewed, and the clinical problems, including the adverse effects of the therapies, are discussed.
authors.affiliation: Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Morikawa
authors.forename: E H
authors.initials: EH
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Kishida
authors.forename: Y
authors.initials: Y
authors.lastname: Ohnaka
authors.forename: H
authors.initials: H
authors.lastname: Nikaido
authors.forename: T
authors.initials: T
authors.lastname: Ozawa
authors.forename: S
authors.initials: S
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D020152:Antithrombin III Deficiency / Q000097:blood / Q000151:congenital / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy*; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants