Quantification of the effect of inhaled budesonide on airway inflammation in intermittent asthma by bronchitis index.
The bronchitis index (BI) is a scoring system for the visual quantification of airway inflammation by flexible bronchoscopy. A prospective study was carried out to determine whether patients with intermittent asthma present a considerable visible airway inflammation. Ten steroid-naive patients with intermittent asthma taking only inhaled beta2-agonists were enrolled and received budesonide (800 microg/day) over a period of 4 weeks. The airway inflammation was assessed by flexible electronic videobronchoscopy before and after the steroid treatment phase and quantified using the BI. Despite normal pulmonary function, all patients with intermittent asthma showed a marked visible airway inflammation that was reversed by a 4-week treatment with the inhaled steroid budesonide. The present study demonstrates that the BI may be useful as a clinical research tool for the assessment and quantification of airway inflammation in asthma. Furthermore, our results support the widely recognized theory that airway inflammation is present even in patients with mild asthma, and emphasize the necessity of an early therapy with inhaled steroids.
John
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M
Department of Internal Medicine I, University Hospital Charité of Humboldt-University Berlin, Germany. matthias.john@charite.de
Fietze
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I
Borges
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Oltmanns
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Schmidt
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B
Witt
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D000280:Administration, Inhalation; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy*; D001980:Bronchi / Q000187:drug effects / Q000473:pathology*; D001991:Bronchitis / Q000175:diagnosis*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001999:Bronchoscopy; D019819:Budesonide / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index
D001993:Bronchodilator Agents; D019819:Budesonide