title: Left ventricular wave speed.
abstract: Left ventricular (LV) wave speed (LVWS) was studied experimentally and confirmed in theory. Combining the definition of elastance (E) with the equations for the conservation of mass and momentum shows that LVWS is proportional to the square root of ELA, where L is long-axis length and A is the cross-sectional area, and the density of the blood. (We defined ELA = gamma, where gamma is compressibility.) We studied nine open chest, anesthetized dogs, three of which were studied during caval constriction when LV end-diastolic pressure was < or =0 mmHg. The hearts were paced at approximately 90 beats/min, and LV cross-sectional area was measured by using two pairs of ultrasonic crystals; E was calculated from the LV pressure-area loop. A pulse generator was connected to the LV apex, and LVWS was measured by using two pressure transducers: one near the apex and the other near the base. Their distance was measured roentgenographically and compared with the diameter of a reference ball. LVWS ranged from approximately 1 m/s during diastole to approximately 10 m/s during systole. The slope of the log c (where c is wave speed) vs. log gamma was 0.546, which is in agreement with theory (0.5). When gamma < or = 0, LVWS was approximately 1.5 m/s.
authors.affiliation: Department of Medicine and Physiology and Biophysics, University of Calgary Health Science Centre, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1.
authors.forename: J J
authors.initials: JJ
authors.lastname: Wang
authors.forename: K H
authors.initials: KH
authors.lastname: Parker
authors.forename: J V
authors.initials: JV
authors.lastname: Tyberg
mesh_terms: D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D004548:Elasticity; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D011312:Pressure; D011674:Pulse; D013997:Time Factors; D016277:Ventricular Function, Left