Regulation of translation via TOR signaling: insights from Drosophila melanogaster.
The target of rapamycin (TOR) proteins are large protein kinases evolutionarily conserved from yeast to human. A large body of evidence demonstrates that TOR proteins function in a nutrient-sensing checkpoint whose role is to restrict growth under conditions of low nutrient availability. Under such conditions, TOR blocks the transmission of growth-promoting signals from extracellular stimuli. Recent data obtained by genetic studies in the fruit fly Drosophila melanogaster demonstrate the importance of both insulin-like signaling and TOR signaling in promoting growth. Importantly, these studies identified a major downstream target of TOR and insulin-like signaling as the translational machinery.
Miron
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M
Department of Biochemistry and McGill Cancer Center, McGill University, Montréal, Québec, Canada.
Sonenberg
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N
D064413:3-Phosphoinositide-Dependent Protein Kinases; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004331:Drosophila melanogaster; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011972:Receptor, Insulin / Q000187:drug effects; D020123:Sirolimus / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D011972:Receptor, Insulin; D064413:3-Phosphoinositide-Dependent Protein Kinases; D017346:Protein Serine-Threonine Kinases; D020123:Sirolimus