title: Limits of clinical tests to screen autonomic function in diabetes type 1.
abstract: OBJECTIVE
  A precocious detection of cardiac autonomic dysfunction is of major clinical interest that could lead to a more intensive supervision of diabetic patients. However, classical clinical exploration of cardiac autonomic function is not easy to undertake in a reproducible way. Thus, respective interests of autonomic nervous parameters provided by both clinical tests and computerized analysis of resting blood pressure were checked in type 1 diabetic patients without orthostatic hypotension and microalbuminuria.
  
  
  METHODS
  Thirteen diabetic subjects matched for age and gender to thirteen healthy subjects volunteered to participate to the study. From clinical tests (standing up, deep breathing, Valsalva maneuver, handgrip test), autonomic function was scored according to Ewing's methodology. Analysis of resting beat to beat blood pressure provided autonomic indices of the cardiac function (spectral analysis or Z analysis).
  
  
  RESULTS
  5 of the 13 diabetic patients exhibited a pathological score (more than one pathological response) suggesting the presence of cardiovascular autonomic dysfunction. The most discriminative test was the deep breathing test. However, spectral indices of BP recordings and baro-reflex sensitivity (BRS) of these 5 subjects were similar to those of healthy subjects and of remaining diabetic subjects.
  
  
  CONCLUSIONS
  Alteration in Ewing's score given by clinical tests may not reflect an alteration of cardiac autonomic function in asymptomatic type 1 diabetic patients, because spectral indices of sympathetic and parasympathetic (including BRS) function were within normal range. Our results strongly suggest to confront results provided by both methodologies before concluding to an autonomic cardiac impairment in asymptomatic diabetic patients.
authors.affiliation: Département de Néphrologie et Hypertension Artérielle, Hopital E. Herriot, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Ducher
authors.forename: D
authors.initials: D
authors.lastname: Bertram
authors.forename: I
authors.initials: I
authors.lastname: Sagnol
authors.forename: C
authors.initials: C
authors.lastname: Cerutti
authors.forename: C
authors.initials: C
authors.lastname: Thivolet
authors.forename: J P
authors.initials: JP
authors.lastname: Fauvel
mesh_terms: D000328:Adult; D017668:Age of Onset; D000704:Analysis of Variance; D001341:Autonomic Nervous System / Q000502:physiology / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000175:diagnosis / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D012016:Reference Values; D015203:Reproducibility of Results
chemical_list: D006442:Glycated Hemoglobin