title: Effects of simvastatin on the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia.
abstract: We studied the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia before and after treatment with simvastatin. Individual phospholipids were separated by thin-layer chromatography on glass plates coated with silica gel. It was found that apart from hypolipidemic effect, simvastatin changed the concentration and phospholipid composition of high-density lipoproteins, which improved their cholesterol-accepting and cholesterol-transporting properties.
authors.affiliation: Department of Metabolic Disorders, State Research Center of Preventive Medicine, Russian Ministry of Health, Moscow.
authors.forename: I N
authors.initials: IN
authors.lastname: Ozerova
authors.forename: I V
authors.initials: IV
authors.lastname: Paramonova
authors.forename: A M
authors.initials: AM
authors.lastname: Olfer'ev
authors.forename: N M
authors.initials: NM
authors.lastname: Akhmedzhanov
authors.forename: M A
authors.initials: MA
authors.lastname: Aleksandrova
authors.forename: N V
authors.initials: NV
authors.lastname: Perova
mesh_terms: D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002308:Cardiolipins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000737:chemistry*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008244:Lysophosphatidylcholines / Q000097:blood; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood; D010714:Phosphatidylethanolamines / Q000097:blood; D010743:Phospholipids / Q000032:analysis / Q000097:blood*; D019821:Simvastatin / Q000494:pharmacology*; D013109:Sphingomyelins / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D002308:Cardiolipins; D008076:Cholesterol, HDL; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D013109:Sphingomyelins; D014280:Triglycerides; D002784:Cholesterol; D019821:Simvastatin