title: Synthesis of 5-methylamino-2'-deoxyuridine derivatives.
abstract: Reductive amination of 3',5'-O-(tetraisopropyldisilyloxane-1,3-diyl)-2'-deoxy-5-formyluridine with several aliphatic and aromatic amines, in various solvents, is described. In the case of aliphatic amines, the expected C-5 substituted methylamino pyrimidine nucleosides are formed along with by-products deriving from opening of the pyrimidine ring. Relative amounts of the by-products depend upon the polarity of the solvent employed.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Catalanotti
authors.forename: A
authors.initials: A
authors.lastname: Galeone
authors.forename: L
authors.initials: L
authors.lastname: Mayol
authors.forename: G
authors.initials: G
authors.lastname: Oliviero
authors.forename: D
authors.initials: D
authors.lastname: Rigano
authors.forename: M
authors.initials: M
authors.lastname: Varra
mesh_terms: D000588:Amines / Q000737:chemistry*; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009705:Nucleosides / Q000138:chemical synthesis*
chemical_list: D000588:Amines; D009705:Nucleosides; D003857:Deoxyuridine