Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes.
Eight carbohydrate-pendant platinum(II) complexes have been synthesized from carbohydrate-diamine conjugates. D-Glucose, D-mannose, D-galactose, D-xylose, and L-glucose are attached to the dichloroplatinum(II) moiety by 1,3- or 1,2-diaminopropane chelates through with an O-glycoside bond. All the carbohydrate moieties reduced the toxicity inherent with platinum(II) complexes.
Mikata
Y
Y
KYOUSEI Science Center, Nara Women's University, Nara 630-8506, Japan. mikata@cc.nara-wu.ac.jp
Shinohara
Y
Y
Yoneda
K
K
Nakamura
Y
Y
Brudziñska
I
I
Tanase
T
T
Kitayama
T
T
Takagi
R
R
Okamoto
T
T
Kinoshita
I
I
Doe
M
M
Orvig
C
C
Yano
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology*
C448381:2-glucose-diaminopropane-dichloroplatinum(II); D000970:Antineoplastic Agents; D002241:Carbohydrates; D009944:Organoplatinum Compounds; D002945:Cisplatin