Neurotoxicity of immunosuppressive drugs.
The clinical profile of neurotoxicity caused by immunosuppression has changed. When toxic levels are reached, both cyclosporine and tacrolimus may produce a clinical spectrum that varies from tremor and acute confusional state to status epilepticus and major speech or language abnormalities. Coma has become an unusual manifestation. Magnetic resonance imaging has been better defined, and abnormalities may be more widespread than those in the posterior lobes. These white matter lesions are caused by vasogenic edema, but may lead to apoptosis and cytotoxic edema if exposure is prolonged. Recent evidence suggests inhibition of a drug-efflux pump and dysfunction of the blood-brain barrier by enhanced nitric oxide production.
Wijdicks
E F
EF
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA. wijde@mayo.edu
D006801:Humans; D007166:Immunosuppressive Agents / Q000506:poisoning*; D009420:Nervous System / Q000187:drug effects*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D016377:Organ Transplantation; D015995:Prevalence
D007166:Immunosuppressive Agents