title: Diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide.
abstract: The highly diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide is reported. Homoallylamines with high enantiomeric purity are obtained from the adducts in three steps on removal of the chiral auxiliary by means of a nonreductive protocol. Removal of the auxiliary by hydrogenation leads to the saturated amines, also in high enantiomeric purity. [reaction: see text]
authors.affiliation: Syncom B.V., Kadijk 3, 9747 AT Groningen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: van der Sluis
authors.forename: J
authors.initials: J
authors.lastname: Dalmolen
authors.forename: B
authors.initials: B
authors.lastname: de Lange
authors.forename: B
authors.initials: B
authors.lastname: Kaptein
authors.forename: R M
authors.initials: RM
authors.lastname: Kellogg
authors.forename: Q B
authors.initials: QB
authors.lastname: Broxterman