Prussian blue for treatment of radiocesium poisoning.
Prussian blue is a crystal lattice that exchanges potassium for cesium at the surface of the crystal. When given orally, it binds cesium that is secreted in the gut before it can be reabsorbed. Data suggest that in humans, Prussian blue can reduce cesium's half-life by approximately 43% and reduce total body burdens. Prussian blue is well tolerated at a dosage of 3 g/day with appropriate monitoring of serum potassium levels and observing for signs of constipation. Clinical data on the efficacy of Prussian blue in the management of radiocesium poisoning were evaluated. Articles published in English describing distribution and elimination of cesium in both humans and animals were reviewed, along with articles describing administration of Prussian blue in clinical toxicology.
Thompson
D F
DF
Department Pharmacy Practice, Southwestern Oklahoma State University, Weatherford, USA. thompsd@swosu.edu
Church
C O
CO
D000818:Animals; D000931:Antidotes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002588:Cesium Radioisotopes / Q000493:pharmacokinetics / Q000506:poisoning*; D005295:Ferrocyanides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans
D000931:Antidotes; D002588:Cesium Radioisotopes; D005295:Ferrocyanides; C000170:ferric ferrocyanide