title: [The preparation phosprenyl suppresses diarrhea and cattle infectious rhinotracheitis virus multiplication in sensitive cell cultures].
abstract: Fosprenil suppressed the multiplication of cattle diarrhea virus in calf coronary vessel cell culture. Added to the culture of infected cells in a dose of 200 mg, the drug decreased the virus titer 30-fold in comparison with infected control cultures. Antiviral activity of fosprenil towards infective rhinotracheitis virus multiplication was still higher: in a dose of 100 mg it decreased the virus titer in fetal calf lung culture 100-fold in comparison with the control. Moreover, the cytopathogenic effects of the viruses in infected cultures were 24-48 h delayed under the effect of fosprenil in comparison with infected control cultures. These results recommend fosprenil for the treatment of cattle viral diseases.
authors.forename: S V
authors.initials: SV
authors.lastname: Ozherelkov
authors.forename: R V
authors.initials: RV
authors.lastname: Belousova
authors.forename: L L
authors.initials: LL
authors.lastname: Danilov
authors.forename: A V
authors.initials: AV
authors.lastname: Deeva
authors.forename: S D
authors.initials: SD
authors.lastname: Mal'tsev
authors.forename: A N
authors.initials: AN
authors.lastname: Narovlianskiĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Sanin
authors.forename: A V
authors.initials: AV
authors.lastname: Pronin
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects* / Q000472:pathogenicity; D007242:Herpesvirus 1, Bovine / Q000187:drug effects* / Q000472:pathogenicity; D007241:Infectious Bovine Rhinotracheitis / Q000821:virology*; D011106:Polyisoprenyl Phosphates / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011106:Polyisoprenyl Phosphates; C105485:phosprenyl