title: Postantibiotic effects of antituberculosis agents alone and in combination.
abstract: The postantibiotic effects (PAEs) of seven antimycobacterial agents, tested at their respective peak concentrations in serum alone and in different combinations, against Mycobacterium tuberculosis ATCC 27294 were studied with a radiometric culture system in parallel with the viable count method. Rifampin gave the longest PAE (67.8 h) among the drugs used alone, and combinations of first-line drugs generally gave PAEs longer than 120 h. The data obtained might help provide a better understanding of the scientific basis of intermittently administered antituberculosis chemotherapy.
authors.affiliation: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. chiuychan@cuhk.edu.hk
authors.forename: C Y
authors.initials: CY
authors.lastname: Chan
authors.forename: C
authors.initials: C
authors.lastname: Au-Yeang
authors.forename: W W
authors.initials: WW
authors.lastname: Yew
authors.forename: M
authors.initials: M
authors.lastname: Hui
authors.forename: A F
authors.initials: AF
authors.lastname: Cheng
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004347:Drug Interactions; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D009391:Nephelometry and Turbidimetry
chemical_list: D000995:Antitubercular Agents