Stereoselective synthesis of 7 alpha- and 7 beta-aminocholestanol as potent fungicidal drugs.
Potentially lymphotropic 7 alpha- and 7 beta-aminocholestanol were stereoselectively synthesized. In vitro bioassay studies have shown that these fungicidal lipidic derivatives possess strong antifungal activity against Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles.
Fouace
S
S
Laboratoire de Synthèse et Etude de Substances Naturelles à Activités Biologiques, Université de La Rochelle, Pôle Sciences et Technologies, 17042 La Rochelle, France.
El kihel
L
L
Dherbomez
M
M
Letourneux
Y
Y
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D002175:Candida / Q000187:drug effects; D002777:Cholestanols / Q000138:chemical synthesis / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005437:Flucytosine / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
D000935:Antifungal Agents; D002777:Cholestanols; D000666:Amphotericin B; D005437:Flucytosine