title: Latent inhibition and conditioning in rat strains which show differential prepulse inhibition.
abstract: Latent inhibition (LI) is the retardation of associative conditioning resulting from preexposure of the conditioned stimulus (CS) alone prior to conditioning. Schizophrenic patients show deficient prepulse inhibition (PPI) and, at least acutely, deficient LI as well. We recently found that Brown Norway (BN) rats show a PPI deficit compared to Wistar-Kyoto (WKY) rats. If PPI and LI depend on neural processes with common genetic substrates, then LI should be deficient in BN rats as well. Here, LI of a conditioned taste aversion was examined in BN and WKY rats. One group from each strain was preexposed to a saccharin-flavored solution (CS) the day prior to conditioning. For taste aversion conditioning, these two groups again consumed saccharin and were injected with lithium chloride (unconditioned stimulus) 10 min later. A second group from each strain was not preexposed to the CS and was treated identically during conditioning, while a third group was not conditioned (injected with sodium chloride). To test for taste aversion conditioning, saccharin was offered for 20 min/day for 3 days. Nonconditioned BN and WKY rats consumed equal amounts of saccharin on test days. In both strains, conditioned rats showed a saccharin aversion. However, conditioning was less robust in BN than in WKY rats. WKY rats showed good LI of the conditioned taste aversion in that preexposed WKY rats consumed significantly more saccharin on test days than conditioned, nonpreexposed WKY rats. Preexposed BN rats did not consume significantly more saccharin on test days than conditioned, nonpreexposed BN rats. The previously reported deficiency in PPI in the BN rats was confirmed here 1 week after the taste aversion experiment. These results suggest that BN rats show deficient LI as well as PPI and display poor associative learning, a trait also reported in schizophrenia.
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA. Lconti@ucsd.edu
authors.forename: L H
authors.initials: LH
authors.lastname: Conti
authors.forename: A A
authors.initials: AA
authors.lastname: Palmer
authors.forename: J J
authors.initials: JJ
authors.lastname: Vanella
authors.forename: M P
authors.initials: MP
authors.lastname: Printz
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001245:Association Learning / Q000502:physiology; D001362:Avoidance Learning / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology*; D004195:Disease Models, Animal; D006185:Habituation, Psychophysiologic / Q000235:genetics*; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009433:Neural Inhibition / Q000235:genetics*; D051381:Rats; D011914:Rats, Inbred BN; D011921:Rats, Inbred WKY; D013216:Reflex, Startle / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics; D013045:Species Specificity; D013649:Taste / Q000235:genetics