title: Effect of vasodilator hydralazine on tumor microvascular random flow and blood volume as measured by intravoxel incoherent motion (IVIM) weighted MRI in conjunction with Gd-DTPA-Albumin enhanced MRI.
abstract: We studied the effect of hydralazine on tumor blood volume fraction and microvascular random flow velocity magnitude by IVIM weighted MRI in conjunction with dynamic Gd-DTPA-Albumin enhanced MRI. Blood volume fraction maps were obtained from the dynamic Gd-DTPA-Albumin enhanced MRI measurements. The average blood volume fraction of R3230 AC adenocarcinoma decreased from 0.125 +/- 0.022 (s.d.) ml/g to 0.105 +/- 0.018 (s.d.) ml/g (p < 0.001) after the administration of hydralazine at a dose of 5 mg/kg. The microvascular random flow velocity magnitude maps were obtained from the IVIM weighted MRI signals by utilizing the Gd-DTPA-Albumin measured blood volume fractions as an input in the compartmental modeling analysis of the IVIM weighted MRI signal. The random-directional microvascular flow induced MRI signal attenuation was separated from the molecular diffusion induced signal attenuation. Flow induced attenuation was more significant after the administration of hydralazine. The mean microvascular random flow velocity magnitude increased from 0.52 +/- 0.15 (s.d.) mm/sec to 0.73 +/- 0.23 (s.d.) mm/sec (p < 0.05) in the presence of the above blood volume fraction change.
authors.affiliation: Center for Functional Onco-Imaging, College of Medicine, University of California, Irvine, CA 92697-5020, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: M Y
authors.initials: MY
authors.lastname: Su
authors.forename: A
authors.initials: A
authors.lastname: Najafi
authors.forename: O
authors.initials: O
authors.lastname: Nalcioglu
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000503:physiopathology; D000418:Albumins; D000818:Animals; D001783:Blood Flow Velocity; D001810:Blood Volume; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006830:Hydralazine / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply* / Q000503:physiopathology; D008833:Microcirculation; D023421:Models, Animal; D051381:Rats; D011916:Rats, Inbred F344; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000418:Albumins; D003287:Contrast Media; D014665:Vasodilator Agents; C058946:albumin-(gadolinium-DTPA); D006830:Hydralazine; D019786:Gadolinium DTPA