title: Emotional outcome of adolescents and young adults with early and continuously treated phenylketonuria.
abstract: OBJECTIVE
  To assess the emotional functioning of adolescents and young adults with early and consistently treated phenylketonuria (PKU).
  
  
  METHODS
  Twenty PKU-affected participants, ages 14-25, were compared with age-matched chronically ill (n = 17) and peer (n = 16) controls on a structured clinical interview, the Minnesota Multiphasic Personality Inventory, and the Tennessee Self-Concept Scale-2. Affected participants and nonparticipants were assessed using a multidomain assessment of functioning interview.
  
  
  RESULTS
  There were no significant differences between groups for observable psychiatric disorders or emotional and functional symptoms. No significant differences were found in self-concept. Although there were no differences between groups for IQ or treatment variables, PKU-affected participants were more likely than nonparticipants to have sought help for psychological concerns.
  
  
  CONCLUSIONS
  Results suggest that early-treated PKU-affected adolescents and young adults do not show a higher risk for psychological disturbance than appropriate controls.
authors.affiliation: University of Minnesota, USA. jzsulliv@nmh.org
authors.forename: J E
authors.initials: JE
authors.lastname: Sullivan
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D010553:Personality Development; D010649:Phenylalanine / Q000008:administration & dosage; D010661:Phenylketonurias / Q000178:diet therapy / Q000523:psychology*; D012307:Risk Factors; D012803:Sick Role
chemical_list: D010649:Phenylalanine