Simulation of the evolution of genomic complexity.
A general evolutionary trend is the generation of organisms of increasing complexity, notwithstanding that reduction and simplification phenomena do occur in the evolutionary process. This paper proposes an evolutionary model incorporating the mechanisms of gene amplification and deletion. The evolutionary process leading to genomic complexity and the coexistence of simpler organisms with complicated ones were both simulated using the proposed model. The model was also used to investigate the influence of various factors on the evolution of complexity. The simulations indicated that the evolution of complexity is largely influenced by adaptation to complicated environments. Nevertheless, complex organisms require relatively more resources for survival and replication, which limits the on going tendency towards complexity. Moreover, the analysis showed that if the environment varies rapidly and the profit obtained from complexity is greater than the resources consumed, selection will tend to favor complexity. However, high living cost will tend to limit the trend of complexity and if the environment is relatively stable, reduction and simplification will become the dominant trends.
Lu
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X
State Key Laboratory of Intelligent Technology and System, Bioinformatics Institute, Tsinghua University, Beijing 100084, People's Republic of China. luxin96@mails.tsinghua.edu.cn
Li
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Y
D000818:Animals; D005075:Biological Evolution; D004777:Environment; D005784:Gene Amplification; D017353:Gene Deletion; D016678:Genome; D008957:Models, Genetic; D009154:Mutation; D012098:Reproduction; D012641:Selection, Genetic