title: Isolated calf vein thrombosis: comparison of MR venography and conventional venography after initial sonography in symptomatic patients.
abstract: OBJECTIVE
  The authors performed this study to compare magnetic resonance (MR) venography and conventional venography in the diagnosis of deep venous thrombosis (DVT) in the calf after sonography.
  
  
  METHODS
  Sonography was performed in 595 patients who were suspected of having lower-extremity DVT. Patients with positive above-knee duplex sonograms, allergy to iodinated contrast material, renal insufficiency, or cardiac pacemakers and patients who were obese were excluded. The remaining 73 patients were asked to undergo MR venography and conventional venography. All studies were to be performed within 48 hours of the clinical diagnosis and according to standard clinical practice. Images were interpreted by radiologists who were blinded to the results of other modalities. Two separate analyses were performed: one in which conventional venography was used as the standard of reference, and one in which the presence of at least two positive studies for thrombus was considered diagnostic.
  
  
  RESULTS
  Although 36 patients agreed to participate in the study, only 14 underwent MR venography and conventional venography within 48 hours of the clinical diagnosis. With use of any two positive studies for confirmation, acute DVT was diagnosed in three patients. Conventional venography depicted two of the three cases, whereas sonography and MR venography each depicted all three. The findings were concordant in only five of the 14 patients.
  
  
  CONCLUSIONS
  Moderate discrepancy among modalities was demonstrated. This suggests radiologists should undertake comparisons among these three modalities for the detection of calf DVT. In patients with a high clinical suspicion, a second modality may be useful if the initial study is negative.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: G T
authors.initials: GT
authors.lastname: Sica
authors.forename: M E
authors.initials: ME
authors.lastname: Pugach
authors.forename: L S
authors.initials: LS
authors.lastname: Koniaris
authors.forename: S Z
authors.initials: SZ
authors.lastname: Goldhaber
authors.forename: J F
authors.initials: JF
authors.lastname: Polak
authors.forename: A
authors.initials: A
authors.lastname: Mukerjee
authors.forename: C M
authors.initials: CM
authors.lastname: Tempany
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000000981:diagnostic imaging