[Protective effect of tanshinone IIA on acute hepatic injury in mice].
OBJECTIVE
To study the effect of tanshinone IIA on two models of acute hepatic injury in mice.


METHODS
Two acute hepatic injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-GalN) in mice were used. ALT, AST in serum and MDA in liver homogenate were used as indexes.


RESULTS
Tanshinone IIA (10 mg.kg-1, 20 mg.kg-1, 30 mg.kg-1), similar to biophenyldicarboxylate, could decrease ALT, AST in serum and MDA in hepatic homogenate on acute hepatic injury induced by CCl4 and D-GalN.


CONCLUSIONS
Tanshinone IIA possessed obvious protective effect against liver injury induced by CCl4 or D-GalN.
Liu
Y
Y
First Military Medical University, Guangzhou 510515.
Chen
H
H
Jiang
Y
Y
D045784:Abietanes; D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010616:Phenanthrenes / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy
D045784:Abietanes; D010616:Phenanthrenes; C021751:tanshinone