Thyroid hormones modify susceptibility to lidocaine-kindling in rats.
Lidocaine, a local anesthetic, produces seizures by unknown central mechanisms. The objective of this study was to investigate the effect of cellular metabolism alteration, by changing thyroid hormones levels, on susceptibility to lidocaine-kindling. Lidocaine was administered daily (60 mg/Kg x day, i.p.) to rats treated with thyroxine (300 microg/Kg x day) or methimazole (60 mg/Kg day), dissolved in drinking water. After the 18th lidocaine administration, the cumulative percent of animals convulsed was higher (100%) for the methimazole-treated group and lower (20%) for the thyroxine-treated group, compared to the control group (40%). The results suggest that susceptibility to lidocaine-kindling depends on neuronal metabolism, which probably affects monoamines uptake mechanisms.
Pacheco-Rosado
J
J
Departamento de Fisiología Mauricio Russek, Escuela Nacional de Ciencias Biológicas, IPN, Carpio y Plan de Ayala, México, DF, Mexico. jprosado@hotmail.com
Zamudio-Hernández
S
S
Chambert
G
G
D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology*; D008012:Lidocaine / Q000009:adverse effects / Q000494:pharmacology; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism; D013963:Thyroid Hormones / Q000502:physiology*
D000779:Anesthetics, Local; D013963:Thyroid Hormones; D008012:Lidocaine