[Effect of epithalone on growth kinetics and functional morphology of M-1 sarcoma].
The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg). The effect lasted for two weeks after injection course. Decrease in proliferative activity was not associated with the drug's immediate cytostatic action on tumor cells. The specific mechanism of the drug's action via blood flow was shown by morphological signs of hemorrhagic necrosis of tumor and increased apoptosis of tumor cells.
Khavinson
V Kh
VKh
Institute of Bioregulation and Gerontology, North-Western Branch of Russian Academy of Medical Sciences, St. Petersburg.
Iuzhakov
V V
VV
Kvetnoĭ
I M
IM
Malinin
V V
VV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects*; D008297:Male; D009368:Neoplasm Transplantation; D009842:Oligopeptides / Q000494:pharmacology*; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology; D051381:Rats; D012513:Sarcoma, Experimental / Q000276:immunology / Q000473:pathology*
D000975:Antioxidants; D009842:Oligopeptides; D018809:Proliferating Cell Nuclear Antigen; C421253:alanyl-glutamyl-aspartyl-glycine