title: Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock.
abstract: Pyruvate is an energy substrate that has both inotropic and antioxidant properties. In this study, we tested the hypothesis that survivorship would be better after resuscitation with 1.7% sodium pyruvate than 0.9% sodium chloride in a profound hemorrhagic shock model. The study was performed in a blinded manner. Rats were randomly assigned into two groups (ten in each group), a sodium chloride resuscitation group and a sodium pyruvate resuscitation group. After a 60-min shock period, we infused 80 ml/kg of a resuscitation solution. We continuously monitored mean arterial pressure and heart rate for 50 min after resuscitation. We recognized death by the disappearance of blood pressure pulsation and precordial movement. We performed a comparison of survivorship at 50 min post resuscitation using a Z-test of proportions. Nine (90%) of the animals that received sodium pyruvate were living 50 min after resuscitation, whereas only three (30%) of the animals that received sodium chloride survived to the same time point. We conclude that sodium pyruvate is better than sodium chloride as a resuscitation solution in a model of profound hemorrhagic shock.
authors.affiliation: Department of Pediatrics, College of Medicine, University of Florida, 1600 SW Archer Road, PO Box 100296, Gainesville, FL 32610-0296, USA.
authors.forename: P N
authors.initials: PN
authors.lastname: Slovin
authors.forename: C J
authors.initials: CJ
authors.lastname: Huang
authors.forename: J R
authors.initials: JR
authors.lastname: Cade
authors.forename: C E
authors.initials: CE
authors.lastname: Wood
authors.forename: O
authors.initials: O
authors.lastname: Nasiroglu
authors.forename: M
authors.initials: M
authors.lastname: Privette
authors.forename: P
authors.initials: P
authors.lastname: Orbach
authors.forename: J W
authors.initials: JW
authors.lastname: Skimming
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D019344:Lactic Acid / Q000097:blood; D008297:Male; D019289:Pyruvic Acid / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy* / Q000401:mortality*; D012965:Sodium Chloride / Q000627:therapeutic use*; D015996:Survival Rate
chemical_list: D001786:Blood Glucose; D002316:Cardiotonic Agents; D019344:Lactic Acid; D012965:Sodium Chloride; D019289:Pyruvic Acid