Cytokine production inhibitors produced by a fungus, Oidiodendron griseum.
A series of diterpenes were isolated from the fermentation broth of a fungus, Oidiodendron griseum CL37215. The diterpenes were identified as LL-Z1271alpha, LL-Z1271gamma, CJ-14,445, PR 1388, CJ-14,604 and a new diterpene, CJ-14,515. They inhibited both lipopolysaccharide-induced interleukin-1beta and tumor necrosis factor-alpha production in human whole blood with IC50s of the range from 0.049 to 100 microM.
Ichikawa
K
K
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc., Chita-gun, Aichi, Japan. katsuomi.ichikawa@japan.pfizer.com
Hirai
H
H
Ishiguro
M
M
Kambara
T
T
Kato
Y
Y
Kim
Y J
YJ
Kojima
Y
Y
Matsunaga
Y
Y
Nishida
H
H
Shiomi
Y
Y
Yoshikawa
N
N
Huang
L H
LH
Kojima
N
N
D001203:Ascomycota / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000097:blood; D007930:Leucine / Q000378:metabolism; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000378:metabolism
D004224:Diterpenes; D007375:Interleukin-1; D011753:Pyrones; D013729:Terpenes; D014409:Tumor Necrosis Factor-alpha; C013363:LL-Z 1271alpha; D007930:Leucine