title: Long term metabolic consequences of ileal pouch-anal anastomosis for ulcerative colitis.
abstract: OBJECTIVE
  Chronic inflammation in the ileal pouch is the most significant late complication after ileal pouch-anal anastomosis (IPAA). It leads to changes in mucosal morphology, with consequent decreased vitamin B12, bile acid and cholesterol absorption documented. The aims of this study were to evaluate long term metabolic consequences at least 5 yr after IPAA and the influence of pouchitis on pouch histology and on bile acid, lipid, and vitamin B12, A, E, and D metabolism.
  
  
  METHODS
  A total of 104 patients with a J-pouch who were operated on between 1985 and 1994, as well as 21 ulcerative colitis patients with a conventional ileostomy were enrolled for the study. Routine blood tests, vitamin status, vitamin B12 levels, and bile acid absorption were determined, as well as endoscopy with biopsies. The pouchitis disease activity index (PDAI) was calculated. On the basis of histology, IPAA patients were divided into three subgroups: 1) those with no villous atrophy, 2) those with partial villous atrophy, and 3) those with subtotal or total villous atrophy.
  
  
  RESULTS
  Incidence of pouchitis was 42.3%, and was strongly associated with villous atrophy. In IPAA patients with subtotal or total villous atrophy (32.7%), serum levels of albumin, calcium, total cholesterol, triglycerides, and vitamin E were significantly reduced (p < 0.05). The lowest bile acid and vitamin B12 absorption rates were seen in patients with inflammation in the proximal limb. Vitamin D deficiency was seen in 10.6%, and vitamin A and B12 deficiency in approximately 5% of IPAA patients.
  
  
  CONCLUSIONS
  Metabolic consequences after IPAA are associated with pouchitis, grade of villous atrophy, and extent of inflammation in the remaining ileum. Patients with active chronic inflammation need long term follow-up.
authors.affiliation: Department of Gastroenterology, Helsinki University Central Hospital, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kuisma
authors.forename: H
authors.initials: H
authors.lastname: Nuutinen
authors.forename: P
authors.initials: P
authors.lastname: Luukkonen
authors.forename: H
authors.initials: H
authors.lastname: Järvinen
authors.forename: A
authors.initials: A
authors.lastname: Kahri
authors.forename: M
authors.initials: M
authors.lastname: Färkkilä
mesh_terms: D000328:Adult; D000368:Aged; D001284:Atrophy; D001647:Bile Acids and Salts / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000601:surgery*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019449:Pouchitis / Q000378:metabolism* / Q000473:pathology*; D013997:Time Factors; D014805:Vitamin B 12 / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D008055:Lipids; D014805:Vitamin B 12