title: [Hypertension in pregnancy].
abstract: Hypertension occurs in 10 to 15 p cent of pregnancies. Among them, 10 to 20% also have proteinuria. This situation defines preeclampsia, and involves a serious threat on foetal and even maternal prognosis. Presence of the hepatic (HELLP) syndrome still severely worsens the prognosis. Pathophysiology of preeclampsia is based on a very early abnormality of placentation, leading to insufficient blood supply to the foeto-placental unit. At the maternal level, the main consequence of placental ischemia is diffuse endothelial dysfunction, responsible for systemic vasoconstriction and clotting abnormalities. In such a context, merely lowering blood pressure with drugs is quite inefficient, or even harmful. The prognosis of this disease is mainly related to the pertinence of obstetrical management. An early preventive strategy is the most logical approach of preeclampsia, its modalities remain under discussion. Hypertension has a high recurrence rate on subsequent pregnancies. It is most often linked to a high global vascular risk level, therefore many of those patients will become permanent hypertensives in the near future.
authors.affiliation: Service de médecine interne, hôpital Tenon, 4, rue de la Chine, 75970 Paris.
authors.forename: M
authors.initials: M
authors.lastname: Beaufils
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004617:Embolism / Q000209:etiology; D005260:Female; D017359:HELLP Syndrome; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000473:pathology / Q000628:therapy; D007511:Ischemia / Q000209:etiology; D011225:Pre-Eclampsia / Q000473:pathology / Q000628:therapy*; D011247:Pregnancy; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents