title: [In vitro testing for drug resistance and drug sensitivity in clinical oncology].
abstract: In vitro methods for testing chemosensitivity and chemoresistance can contribute considerably to more individual chemotherapy of a given patient. Different tests which reflect with a different reliability and specificity the probable ineffectiveness of chemotherapy can be divided into several categories: 1. Indirect tests associated with general biological activity of the tumour. 2. Tests based on the specific relationship to a certain cytostatic. 3. Examination of hormonal receptors. 4. Direct tests based on testing of the sensitivity or resistance of a tumour to different cytostatics in primocultures or stabilized cultures. The submitted review presents information on different methods.
authors.affiliation: Univerzitní onkologické centrum, oddĕlení klinické onkologie FN Brno, pracovistĕ Bohunice.
authors.forename: I
authors.initials: I
authors.lastname: Kiss
authors.forename: J
authors.initials: J
authors.lastname: Zaloudík
authors.forename: R
authors.initials: R
authors.lastname: Vyzula
authors.forename: J
authors.initials: J
authors.lastname: Tomásek
authors.forename: J
authors.initials: J
authors.lastname: Maláska
authors.forename: O
authors.initials: O
authors.lastname: Coufal
authors.forename: I
authors.initials: I
authors.lastname: Kocáková
mesh_terms: D000818:Animals; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D014407:Tumor Cells, Cultured / Q000187:drug effects