Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation.
This study investigated possible associations between selected polymorphisms in the dopamine receptor genes DRD1 and DRD3 with the presence of psychotic phenomena or aggressive behaviour in a community based cohort of 134 patients with late onset Alzheimer's disease. An association was found between the presence of psychotic symptoms and aggressive behaviour and the DRD1 polymorphism and between the presence of psychosis, but not aggression, and the DRD3 polymorphism. Specifically, carriers of the DRD1 B2 allele were more likely to be aggressive or experience hallucinations whereas homozygous carriers of the DRD3 1 allele were more likely to experience delusions.
Holmes
C
C
University of Southampton, Community Clinical Sciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, West End, Southampton SO30 3JB, UK. ch4@soton.ac.uk
Smith
H
H
Ganderton
R
R
Arranz
M
M
Collier
D
D
Powell
J
J
Lovestone
S
S
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000374:Aggression / Q000523:psychology; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics* / Q000523:psychology; D003702:Delusions / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006212:Hallucinations / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic / Q000235:genetics*; D011618:Psychotic Disorders / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D012042:Registries; D006113:United Kingdom / Q000453:epidemiology
C493593:DRD3 protein, human; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3