Extravascular lung water in the exercising horse.
Seven Standardbred horses were exercised on a treadmill at speeds (approximately 12 m/s) producing maximal heart rate, hypoxemia, and a mean pulmonary arterial pressure of approximately 75 mmHg. Extravascular lung water was measured by using transients in temperature and electrical impedance of the blood caused by a bolus injection of cold saline solution. Lung water was approximately 3 ml/kg body wt when standing but did not increase significantly with exertion. We conclude that any increase in fluid extravasation from the pulmonary hypertension accumulates in the lung at a level that is less than that detectable by this method. At maximal exertion, the volume of blood measured between the jugular vein and the carotid artery increased by approximately 8 ml/kg, and the actively circulating component of the systemic blood volume increased by approximately 17 ml/kg with respect to corresponding values obtained when walking before exertion. These volume increases, reflecting recruitment and dilatation of capillaries, increase the area for respiratory gas exchange and offset the reduced transit times that would otherwise be imposed by the approximately eightfold increase in cardiac output at maximal exertion.
Wilkins
P A
PA
Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Gleed
R D
RD
Krivitski
N M
NM
Dobson
A
A
D000818:Animals; D001783:Blood Flow Velocity; D001810:Blood Volume; D001834:Body Water / Q000378:metabolism*; D005260:Female; D006439:Hemodynamics; D006736:Horses / Q000502:physiology*; D006976:Hypertension, Pulmonary / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D008168:Lung / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D011654:Pulmonary Edema / Q000209:etiology