title: Progressive supranuclear palsy.
abstract: This review concentrates on the molecular pathology of the protein tau, including its expression in various regions of the brain. The role of post-translational modifications in fibrillogenesis is also discussed, particularly hyperphosphorylation and glycation. However, the initiating event that causes aberrant tau processing remains unclear.
authors.affiliation: Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK.
authors.forename: K
authors.initials: K
authors.lastname: Tawana
authors.forename: D B
authors.initials: DB
authors.lastname: Ramsden
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology; D016923:Cell Death; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D013494:Supranuclear Palsy, Progressive / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D020033:Protein Isoforms; D016875:tau Proteins