title: Anaphylactoid reactions associated with menstruation affecting two sisters.
abstract: Cyclical anaphylactoid reactions associated with menstruation are exceedingly rare. We report two sisters who were both affected, one severely and one mildly. Treatment involved suppression of menstruation and use of a cyclooxygenase-2 (COX-2) inhibitor. An abnormal reaction to prostaglandins, perhaps produced by COX-2 enzyme activity in the endometrium, is a possible mechanism.
authors.affiliation: Department of Thoracic Medicine, Cairns Base Hospital, QLD.
authors.forename: G
authors.initials: G
authors.lastname: Simpson
authors.forename: D
authors.initials: D
authors.lastname: Roomes
authors.forename: M D
authors.initials: MD
authors.lastname: Humphrey
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008598:Menstruation / Q000235:genetics / Q000276:immunology*; D009679:Nuclear Family; D011720:Pyrazoles; D018570:Risk Assessment; D013449:Sulfonamides / Q000008:administration & dosage*; D014581:Urticaria / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics
chemical_list: D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib