Similar therapeutic serum levels attained with emulsified and oil-based preparations of coenzyme Q10.
Studies of the therapeutic efficacy of coenzyme Q10 (CoQ10) have been confounded by the variable bioavailability of numerous CoQ10 preparations. The aims of the present study were to determine the early serum levels attained by two different preparations of CoQ10, a soybean oil-based preparation and a complex micelle emulsion and to assess whether these preparations of oral CoQ10 influence plasma lipid profiles. Twelve healthy individuals received 300 mg CoQ10 daily of either preparation for 7 days in a double-blind cross-over design with a 21-day washout period. Blood samples to determine serum levels of CoQ10 and lipids were taken at baseline, after 24 h and 7 days. Both preparations induced significant increases in serum CoQ10 levels at 24 h and 7 days. These were for soy oil: baseline 0.27 +/- 0.03 mol/L, 24 h 0.50 +/- 0.04 mol/L (180%) and 7 days 0.80 +/- 0.05 mol/L (291%), mean +/- SEM: for emulsion: baseline 0.29 +/- 0.03 mol/L, 24 h 0.45 +/- 0.03 mol/L (150%) and 7 days 0.79 +/- 0.06 mol/L (270%). There were no significant differences between CoQ10 levels for the two preparations at either time point. There was no change in any of the serum lipids following the 7 days treatment. We conclude that administration of either a soy oil suspension or a complex emulsion of CoQ10 increases serum levels to the therapeutic range within 1 week.
Lyon
W
W
Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Melbourne, Victoria, Australia.
Van den Brink
O
O
Pepe
S
S
Wowk
M
M
Marasco
S
S
Rosenfeldt
F L
FL
D000328:Adult; D000975:Antioxidants / Q000032:analysis / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D003067:Coenzymes; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004655:Emulsions; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013024:Soybean Oil; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*
D000975:Antioxidants; D003067:Coenzymes; D004655:Emulsions; D008055:Lipids; D014451:Ubiquinone; D013024:Soybean Oil; C024989:coenzyme Q10