[Analysis of the action of dextran sulfate as a prophylaxis for peritoneal cancer metastasis, and its acting mechanism].
Although peritoneal cancer metastasis has the highest frequency of postoperative recurrence among digestive organ malignant tumors, there is no still decisive treatment. Dextran sulfate (DS) as a prophylaxis for cancer metastasis was examined with respect to its effect on cultured cells. DS was made to act on a strong adhesive neoplasm cell, and the action and acting mechanism were examined with respect to 1. readhesiveness, 2. cell cycle, and 3. gene analysis. The results suggest that: i) Once tumor cells are detached by DS, the free cells do not attach even when DS is removed, and ii) DS causes the cells to stop in the G1/G0 phase.
Fujiyama
J
J
Dept. of Digestive Surgery, Kyoto Prefectural University of Medicine.
Sakakura
C
C
Takagi
T
T
Itoh
T
T
Takemura
M
M
Touma
A
A
Shimomura
K
K
Yunning
H
H
Longhai
H
H
Tsujimoto
H
H
Yamasaki
J
J
Otsuji
E
E
Hagiwara
A
A
Yamagishi
H
H
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D016264:Dextran Sulfate / Q000494:pharmacology* / Q000627:therapeutic use; D008546:Melanoma, Experimental / Q000235:genetics / Q000473:pathology*; D051379:Mice; D010534:Peritoneal Neoplasms / Q000517:prevention & control* / Q000556:secondary*
D016264:Dextran Sulfate