title: Effect of niprisan on single oral dose pharmacokinetics of paracetamol in rats.
abstract: The single oral dose pharmacokinetics of paracetamol was studied alone and after coadministration with NIPRISAN In rats. Paracetamol concentrations were measured in rat plasma using UV-spectrophotometer and the data were fitted into an open two-compartment pharmacokinetic model using the computer program (STATIS Version 3.0). Results indicated no significant difference in the absorption of paracetamol between study and control groups but a significant reduction (p < 0.05) at some sampling time as the dose of NIPRISAN was increased double-fold. The pharmacokinetic parameters showed only 1.51 and 7.19% reduction in AUC(0-infinity) and Cmax respectively for paracetamol (20 mg/kg) + NIPRISAN (500 mg/kg). It was thus concluded that the gastric presence of NIPRISAN did not significantly reduce the absorption of paracetamol in rats.
authors.affiliation: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Garki, Abuja, Nigeria.
authors.forename: B
authors.initials: B
authors.lastname: Adzu
authors.forename: M
authors.initials: M
authors.lastname: Garba
authors.forename: A
authors.initials: A
authors.lastname: Haruna
authors.forename: M
authors.initials: M
authors.lastname: Maman
authors.forename: C
authors.initials: C
authors.lastname: Wambebe
authors.forename: K
authors.initials: K
authors.lastname: Gamaniel
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics*; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics*; D000818:Animals; D000986:Antisickling Agents / Q000494:pharmacology*; D019540:Area Under Curve; D004347:Drug Interactions; D007202:Indicators and Reagents; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D000986:Antisickling Agents; D007202:Indicators and Reagents; C445122:Niprisan; D010936:Plant Extracts; D000082:Acetaminophen