Diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide.
The highly diastereoselective addition of allylzinc bromide to imines derived from (R)-phenylglycine amide is reported. Homoallylamines with high enantiomeric purity are obtained from the adducts in three steps on removal of the chiral auxiliary by means of a nonreductive protocol. Removal of the auxiliary by hydrogenation leads to the saturated amines, also in high enantiomeric purity. [reaction: see text]
van der Sluis
M
M
Syncom B.V., Kadijk 3, 9747 AT Groningen, The Netherlands.
Dalmolen
J
J
de Lange
B
B
Kaptein
B
B
Kellogg
R M
RM
Broxterman
Q B
QB