title: Brownian dynamics study of an open-state KcsA potassium channel.
abstract: Three-dimensional Brownian dynamics simulations are used to study conductance of the KcsA potassium channel using the known crystallographic structure. Employing an open-state channel created by molecular dynamics simulations, current-voltage and current-concentration curves broadly consistent with experimental measurements are obtained. In the absence of an applied potential, the channel houses three potassium ions at positions that are in close agreement with X-ray diffraction maps.
authors.affiliation: Department of Physics, Australian National University, 0200, Canberra, ACT, Australia.
authors.forename: T W
authors.initials: TW
authors.lastname: Allen
authors.forename: S H
authors.initials: SH
authors.lastname: Chung
mesh_terms: D001426:Bacterial Proteins; D004553:Electric Conductivity; D008962:Models, Theoretical; D015221:Potassium Channels / Q000737:chemistry*; D011199:Potentiometry; D055672:Static Electricity
chemical_list: D001426:Bacterial Proteins; D015221:Potassium Channels; C107790:prokaryotic potassium channel