Virus infections and tumors of the oral mucosae. Symposium of the "Arbeitskreis Oralpathologie und Oralmedizin" and the "Arbeitsgemeinschaft Dermatologische Infektiologie der Deutschen Dermatologischen Gesellschaft", Rostock, July 6-7, 2001.
The symposium on Virus Infections and Tumors of the Oral Mucosae was organized as a joint meeting of the Arbeitskreis Oralpathologie and Oralmedizin and the Arbeitsgemeinschaft Dermatologische Infektiologie (ADI) der Deutschen Dermatologischen Gesellschaft. The main topics of the meeting were herpes virus infections, human papillomavirus (HPV) infections and human immunodeficiency virus (HIV) infections of the oral mucosae. Clinically both diagnostic, differential diagnostic and therapeutic aspects of the virus-associated diseases were discussed in several presentations. Another important issue was the role of these viruses, particularly of HPVs, in the origin and development of oral cancer. Apparently besides smoking and alcohol other risk factors comprise high risk HPVs, immunodeficiency and possibly also genetic factors. Whether neonatal early infections may predispose children to a specific cancer risk in their future life is still at a level of discussion. Some arguments, however were shown that tonsillar carcinoma, which shows the highest prevalence of the high-risk HPV 16- DNA sequences between all oral cancer, is possibly an epidemiologically and etiologically distinct tumor. It is argued that this tumor is probably less dependent on classical carcinogens than other oral malignant tumors.
Gross
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Universität Rostock, Medizinische Fakultät, Klinik und Poliklinik für Dermatologie und Venerologie, Augustenstr. 80-85, D-18055 Rostock, Germany. gerd.gross@med.uni-rostock.de
Gundlach
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K
Reichart
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D004279:DNA, Viral / Q000032:analysis; D016158:Genes, p53; D015658:HIV Infections / Q000150:complications*; D006566:Herpesviridae Infections / Q000150:complications*; D006801:Humans; D007972:Leukoplakia, Oral / Q000175:diagnosis / Q000209:etiology; D017676:Lichen Planus, Oral / Q000175:diagnosis / Q000209:etiology; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000209:etiology*; D010212:Papilloma / Q000175:diagnosis / Q000209:etiology; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis; D014412:Tumor Virus Infections / Q000150:complications*
D004279:DNA, Viral; D016212:Transforming Growth Factor beta