The relentless effects of the aging process on protein turnover.
Protein turnover encompasses the processes of protein synthesis and protein degradation. Because of the essential structural and catalytic roles that proteins play in the cell, there has been a long-standing interest in the effects of aging on protein turnover. The purpose of this review is to incorporate relevant data published since the area was previously reviewed and to provide an update on the status of research with particular attention to the pathways of protein degradation.
Ward
W F
WF
Department of Physiology, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. wardw@uthscsa.edu
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D003546:Cysteine Endopeptidases / Q000378:metabolism; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*
D009097:Multienzyme Complexes; D011506:Proteins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex