Comparison of the upper gastrointestinal effects of etodolac and aspirin in healthy dogs.
Fifteen healthy castrated male dogs were separated into three treatment groups that were administered etodolac, aspirin and a placebo orally, respectively. All treatments were continued for 28 days. The animals were examined endoscopically on days 0, 3, 7, 10, 14, 17, 21, 24 and 28. There were no gastrointestinal mucosal lesions in either the etodolac or the placebo group, whereas some gastric lesions developed in the aspirin group after day 17. We considered that etodolac could be used for long-term treatments in dogs with fewer side-effects on the gastric mucosa than aspirin.
Nishihara
K
K
Laboratory of Veterinary Internal Medicine, Obihiro University of Agriculture and Veterinary, Medicine, Hokkaido, Japan.
Kikuchi
H
H
Kanno
T
T
Tanabe
S
S
Sarashina
T
T
Uzuka
Y
Y
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004285:Dogs / Q000378:metabolism*; D016099:Endoscopy, Gastrointestinal / Q000662:veterinary; D017308:Etodolac / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D011897:Random Allocation; D018709:Statistics, Nonparametric
D000894:Anti-Inflammatory Agents, Non-Steroidal; D017308:Etodolac; D001241:Aspirin