title: Grafting of the peritonsillar fossa with an acellular dermal graft to reduce posttonsillectomy pain.
abstract: OBJECTIVE
  Adult tonsillectomy is a common surgical procedure that is accompanied by masked postoperative pain. Analgesics are usually only partially effective, and the use of narcotics such as codeine is often poorly tolerated because of associated nausea. Because the pain associated with tonsillectomy is believed to arise from the large areas of exposed parapharyngeal muscle, we hypothesized that acellular dermal grafting of the peritonsillar fossa, providing biologic coverage to these areas, would result in a notable reduction of postoperative pain.
  
  
  METHODS
  We did a double-blind, prospective study, with 10 adult patients undergoing electrodissection tonsillectomy concurrently with grafting of 1 peritonsillar fossa with an acellular dermal graft (ADG) (AlloDerm, LifeCell Corp, The Woodlands, TX), whereas the other side of the throat received no treatment and was designated as the control side. Patients were examined on postoperative days 1, 7, and 14, and completed pain questionnaires on postoperative days 1, 3, 5, 7, and 14.
  
  
  RESULTS
  ADG grafting of the peritonsillar fossa resulted in a statistically significant reduction in pain (by approximately 50%) on postoperative days 1, 3, 5, and 7, compared with the control side. Two patients experienced partial graft sloughing within the first 10 postoperative days, but no other untoward effects such as bleeding, graft aspiration, or infection, were associated with ADG of the peritonsillar fossa.
  
  
  CONCLUSIONS
  This study suggests that AlloDerm grafting of the peritonsillar fossa is a potentially useful, alternative means of reducing pain in the adult tonsillectomy patient and has potential use in reconstruction of oropharyngeal defects. Because of the cost of the graft, we suggest its use in selected difficult adult cases, but not as part of routine adult tonsillectomy.
authors.affiliation: Division of Facial Plastic Surgery, Department of Otolaryngology, The New York Eye and Ear Infirmary, New York, NY 10003, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Sclafani
authors.forename: A A
authors.initials: AA
authors.lastname: Jacono
authors.forename: J N
authors.initials: JN
authors.lastname: Dolitsky
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001672:Biocompatible Materials; D003094:Collagen; D004311:Double-Blind Method; D004564:Electrocoagulation / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology / Q000601:surgery*; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D016038:Skin Transplantation / Q000379:methods*; D014068:Tonsillectomy / Q000009:adverse effects* / Q000379:methods*; D016896:Treatment Outcome
chemical_list: C440568:Alloderm; D001672:Biocompatible Materials; D003094:Collagen