Glutamate and GABA: a painful combination.
Regulation of release of inhibitory neurotransmitter is a key element of plasticity in dorsal horn function. In this issue of Neuron, Kerchner et al. report that neurotransmitter release from inhibitory dorsal horn neurons is affected by activation of presynaptic kainate-type glutamate receptors.
MacDermott
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Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.
D000818:Animals; D018698:Glutamic Acid / Q000096:biosynthesis / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D020671:Posterior Horn Cells / Q000378:metabolism; D018092:Kainic Acid Receptors / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis / Q000378:metabolism*
D018698:Glutamic Acid; D018092:Kainic Acid Receptors; D005680:gamma-Aminobutyric Acid