Synthesis, characterization and cytotoxicity of lanthanum(III) complexes with novel 1,10-phenanthroline-2,9-bis-alpha-amino acid conjugates.
Eight lanthanum(III) complexes with novel 1,10-phenanthroline-2,9-bis-alpha-amino acid conjugates were synthesized and characterized by elemental analyses, IR, MS, 1H-NMR, thermal analysis and conductance measurement. All lanthanum(III) complexes and the corresponding soluble ligand in water have been assayed for antitumor activity in vitro against HL-60 (human leukocytoma) cells, HCT-8 (human coloadenocarcinoma) cells, BGC-823 (human stomach carcinoma) cells, BeL-7402 (human liver carcinoma) cells and KB (human nasopharyngeal carcinoma) cells. The results show that several complexes have relative activity against different cell lines. In particular, the complexes La(L2) and La(L5) show relatively high activity against the BeL-7402 cell line. Moreover, they are slightly more effective than cisplatin. DNA binding studies indicate that the complex La(L2) possibly interacts with calf thymus DNA by both intercalative and covalent binding.
Wang
Z M
ZM
Department of Chemistry, Nankai University, Tianjin, PR China.
Lin
H K
HK
Zhu
S R
SR
Liu
T F
TF
Zhou
Z F
ZF
Chen
Y T
YT
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007811:Lanthanum / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
D000596:Amino Acids; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D010618:Phenanthrolines; D007811:Lanthanum