title: Effect of testosterone replacement therapy on serum PSA in patients with Klinefelter syndrome.
abstract: The effect of testosterone replacement therapy on serum prostate-specific antigen (PSA) was investigated in 11 patients with Klinefelter syndrome. Significant increases in serum testosterone level and prostate volume were observed after testosterone replacement therapy. However, serum PSA level did not change after testosterone replacement therapy. It would appear that serum PSA is not influenced by exogenous testosterone in patients with Klinefelter syndrome.
authors.affiliation: Department of Urology, Yamagata University School of Medicine, Yamagata-shi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shibasaki
authors.forename: I
authors.initials: I
authors.lastname: Sasagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Yazawa
authors.forename: O
authors.initials: O
authors.lastname: Ichiyanagi
authors.forename: S
authors.initials: S
authors.lastname: Matsuki
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: T
authors.initials: T
authors.lastname: Nakada
mesh_terms: D000328:Adult; D020249:Hormone Replacement Therapy; D006801:Humans; D007713:Klinefelter Syndrome / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging / Q000187:drug effects; D017430:Prostate-Specific Antigen / Q000097:blood*; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use*; D014463:Ultrasonography / Q000379:methods
chemical_list: D013739:Testosterone; D017430:Prostate-Specific Antigen