title: Inhibition of tumor growth by plasminogen-related protein-B.
abstract: BACKGROUND
  Various fragments of the fibrinolytic protein plasminogen can act as antiangiogenic factors and inhibit the growth of primary and metastatic tumors in mice. Plasminogen-related gene-B encodes a putative 9 kDa protein virtually identical to the plasminogen N-terminal activation peptide, a 77-amino acid motif that is liberated from the parent plasminogen molecule during conversion to the serine proteinase plasmin. Previous data have documented enhanced transcription of plasminogen-related gene-B in neoplastic tissues.
  
  
  METHODS
  We have tested the effects of recombinant versions of plasminogen-related protein-B and the plasminogen N-terminal activation peptide on the growth of tumors in mice, employing murine tumor cell lines implanted subcutaneously.
  
  
  RESULTS
  The recombinant plasminogen-related protein-B significantly inhibited the growth of primary tumors in mice, while recombinant plasminogen N-terminal activation peptide elicited only a slight inhibition of tumor growth.
  
  
  CONCLUSIONS
  These data suggest that plasminogen-related protein-B may have utility as a novel cancer therapeutic.
authors.affiliation: Orthopaedic Research Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA. volewis@mail.mdanderson.org
authors.forename: V O
authors.initials: VO
authors.lastname: Lewis
authors.forename: M S
authors.initials: MS
authors.lastname: O'Reilly
authors.forename: M
authors.initials: M
authors.lastname: Gehrmann
authors.forename: M
authors.initials: M
authors.lastname: Llinás
authors.forename: J
authors.initials: J
authors.lastname: Schaller
authors.forename: L
authors.initials: L
authors.lastname: Weissbach
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D005354:Fibrosarcoma / Q000188:drug therapy / Q000473:pathology; D006131:Growth Inhibitors / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010446:Peptide Fragments / Q000494:pharmacology; D010958:Plasminogen / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D006131:Growth Inhibitors; C118420:PLGLB1 protein, human; D010446:Peptide Fragments; D011994:Recombinant Proteins; D010958:Plasminogen