title: Multiple organ failure still a major cause of morbidity but not mortality in blunt multiple trauma.
abstract: BACKGROUND
  Multiple organ failure (OF/MOF) was found to be the major complication after blunt multiple trauma during the last 25 years and was correlated with a high mortality rate. Recently, several publications reported a decreased ARDS-related mortality, but there is little information about mortality rates from posttraumatic MOF. The purpose of this study was to describe the development of MOF-related death after blunt multiple trauma during the last 25 years.
  
  
  METHODS
  Blunt multiple trauma patients with an Injury Severity Score (ISS) > 15 points were included in this evaluation. According to the year of trauma, the population was divided into five groups: years 1975-1980 (n = 317), years 1981-1985 (n = 308), years 1986-1990 (n = 246), years 1991-1997 (n = 368), and years 1998-1999 (n = 122). Main outcome measurements were death, cause of death, and length of ICU stay. Patients dying within the first 24 hours after trauma were excluded. All data indicated in the Results section are presented as mean +/- SEM. Continuous variables were compared by ANOVA. Ordinal variables were analyzed by chi2 contingency table analysis and, if significant, subsequently by Fisher's exact test (two-tailed test, p < 0.05).
  
  
  RESULTS
  Mean ISS remained unchanged between 1975-1980 (ISS 29 +/- 1) and 1998-1999 (ISS 31 +/- 1) (p = 0.56). During the observation period, the mean age increased from 33 +/- 1 years (1975-1980) to 40 +/- 2 years (1998-1999) (p = 0.03). The overall incidence of OF/MOF slightly increased from 25.6% (1975-1980) to 33.6% (1998-1999) (p = 0.1). Length of ICU stay was not different between 1975-1980 (LOS: 14 +/- 1 d) and 1998-1999 (LOS: 19 +/- 2 d) (p = 1.0). The overall mortality decreased significantly, from 28.7% (1975-1980) to 13.9% (1998-1999) (p < 0.001). While the mortality due to severe head injuries remained unchanged (1975-1980, 8.2%; 1998-1999, 9.0%) (p = 0.85), mortality due to OF/MOF decreased significantly (p < 0.001), from 18.0% (1975-1980) to 4.1% (1998-1999). The age of patients dying from OF/MOF increased significantly (p = 0.04) during the observation period, from 44 +/- 3 years (1975-1980) to 63 +/- 6 years (1998-1999).
  
  
  CONCLUSIONS
  Although MOF incidence remains unchanged, there is a significant fall in MOF-related mortality in patients with severe trauma, and death from single organ failure is virtually absent. Severe brain injury is now the leading cause of death in patients with severe multiple injuries admitted to the ICU.
authors.affiliation: Department of Trauma Surgery, Universitätsklinikum Essen, Essen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Nast-Kolb
authors.forename: M
authors.initials: M
authors.lastname: Aufmkolk
authors.forename: S
authors.initials: S
authors.lastname: Rucholtz
authors.forename: U
authors.initials: U
authors.lastname: Obertacke
authors.forename: C
authors.initials: C
authors.lastname: Waydhas
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002423:Cause of Death; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D015994:Incidence; D015601:Injury Severity Score; D007902:Length of Stay; D008297:Male; D009102:Multiple Organ Failure / Q000401:mortality*; D009104:Multiple Trauma / Q000401:mortality*; D011014:Pneumonia / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology; D014949:Wounds, Nonpenetrating / Q000401:mortality*