[Theoretical and experimental approach to the problem of changes in functional capability of cells under the effects of adaptive doses of ionizing radiation].
It is concluded that a dose range from background dose to several cGy may be separated into two parts: a) first--the interval of small doses limited from above by D* which is determined from (1 g (D*/Doc)) < -0.51 g (n/2)), where Dse is an average dose of a single event, n--quantity of irradiated cells; in this interval only one track intersects a sensitive volume; b) second--the interval of low doses, in which in average one track intersects the volume and which is ranged from top D* to bottom Dse. Because events in this region qualitatively are similar to background events, cells in the dose range b) may be adapted to the influence of radiation. The first stage of the adaptive response of cells is associated with chromosome loci (centromere) movement in a cell nucleus and as we suggest the latter is the fundamental mechanism for repairing DSB DNA and switching of gene transcription. Because the movement of chromosome loci both in the resting cells under the adapting doses and in the normal dividing cells is much the same (but the latter lose their function characteristic for differentiated resting cells), it could be assumed that the resting cells under the adapting doses also lose their functional parameters. Under chronic exposure to low doses this functional changes can be principal for discussion on the influence of low doses on health.
Spitkovskiĭ
D M
DM
Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 117478 Russia.
Kuz'mina
I V
IV
D000222:Adaptation, Physiological; D000328:Adult; D001773:Blood Cells / Q000528:radiation effects; D002467:Cell Nucleus / Q000528:radiation effects; D002468:Cell Physiological Phenomena / Q000528:radiation effects; D002477:Cells / Q000528:radiation effects*; D002503:Centromere / Q000528:radiation effects; D002875:Chromosomes / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D006412:Hematopoietic Stem Cells / Q000502:physiology / Q000528:radiation effects; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes / Q000528:radiation effects; D008954:Models, Biological; D009154:Mutation; D011829:Radiation Dosage; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D013997:Time Factors
D004247:DNA