Synthesis and in vitro cytotoxicity of long chain 2-amino alcohols and 1,2-diamines.
The synthesis of enantiomerically pure unsaturated long chain 1,2-diamines and amino alcohols was carried out starting from the corresponding non-natural alpha-amino acids. The in vitro cytotoxicity of the compounds prepared was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). Free 1, 2-diamines proved to be the most active compounds exhibiting IC50 values between 2.0 mM and 3.3 mM.
Markidis
T
T
Department of Chemistry, University of Athens, Panepistimiopolis, Greece.
Padron
J M
JM
Martin
V S
VS
Peters
G J
GJ
Kokotos
G
G
D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000633:toxicity*; D000818:Animals; D003959:Diamines / Q000138:chemical synthesis* / Q000633:toxicity*; D004354:Drug Screening Assays, Antitumor; D051379:Mice; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000605:Amino Alcohols; D003959:Diamines