The effect of transcranial magnetic stimulation on reciprocal inhibition in the human leg.
The effect of magnetic stimulation on reciprocal Ia inhibition of the human leg was investigated. Stimulation of the common peroneal nerve at the fibula head at the threshold of the alpha motoneuron axons resulted in inhibition of the soleus (SOL) H reflex at a conditioning-test interval of 2 ms. Magnetic stimulation over the contralateral motor cortex resulted in complex modulations of the SOL H reflex, including a short latency facilitation followed by inhibition. This inhibition may have been conveyed by Ia inhibitory interneurons projecting to SOL motoneurons. To test for convergence, whether or not the magnetic stimulation was capable of facilitating disynaptic reciprocal Ia inhibition of the SOL H reflex induced by stimulation of the peroneal nerve, the two stimuli were given together or separately. We observed the inhibition significantly increased when the two stimuli were given together than separately. These results suggest that the Ia inhibitory interneurons projecting to SOL motoneurons in humans might receive convergent input from the motor area of the brain and from Ia afferents of the tibialis anterior (TA) muscle in humans as well as in other animals.
Masakado
Y
Y
Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan.
Muraoka
Y
Y
Tomita
Y
Y
Chino
N
N
D000328:Adult; D001921:Brain / Q000502:physiology*; D004558:Electric Stimulation; D006801:Humans; D007866:Leg / Q000294:innervation / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D010543:Peroneal Nerve / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012018:Reflex / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D050781:Transcranial Magnetic Stimulation