title: Optical imaging of neural activity in multiple auditory cortical fields of guinea pigs.
abstract: Neural activity of multiple fields in the auditory cortex of anesthetized guinea pigs in response to pure tones was visualized by optical recording using a voltage-sensitive dye (RH795). Ten auditory fields were identified based on the tonotopic organization and response latency: the core fields consisting of the primary (AI) and secondary (AII) fields and surrounding belt areas consisting of dorso-anterior (DA), dorsal (D), dorso-posterior (DP), posterior (P), ventro-posterior (VP), ventro-medial (VM), ventro-anterior (VA) and ventral (V) fields. Tonotopic organization was observed in all the fields apart from DA, D, DP and V. Spatio-temporal displays suggest that the auditory information spreads from the core fields of AI and AII to belt fields via three distinct (dorsocaudal, caudal and ventrorostral) pathways.
authors.affiliation: Department of Neurophysiology, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Horikawa
authors.forename: A
authors.initials: A
authors.lastname: Hess
authors.forename: M
authors.initials: M
authors.lastname: Nasu
authors.forename: Y
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: H
authors.initials: H
authors.lastname: Scheich
authors.forename: I
authors.initials: I
authors.lastname: Taniguchi
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001303:Auditory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods*; D001330:Electronic Data Processing / Q000295:instrumentation / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005456:Fluorescent Dyes; D006168:Guinea Pigs; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D008856:Microscopy, Fluorescence / Q000295:instrumentation / Q000379:methods; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013343:Styrenes
chemical_list: D005456:Fluorescent Dyes; C096453:RH 795; D013343:Styrenes