title: Facile acylation of sterically hindered alcohols through ketene intermediates.
abstract: [reaction--see text] Carboxylic acids possessing strongly electron withdrawing substituents in the alpha-position in the presence of DCC acylate sterically hindered and chemically sensitive alcohols. The pattern of reactivity, the deuteration experiments, and the formation of a product derived from a [4 + 2] cycloaddition reaction corroborate the existence of ketene intermediates in the reaction.
authors.affiliation: Department of Organic Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Nahmany
authors.forename: A
authors.initials: A
authors.lastname: Melman