title: Newer macrolides as empiric treatment for acute Q fever infection.
abstract: The effectiveness of newer macrolides in acute Q fever for 113 patients was recorded. The mean times to defervescence were 2.9 days for doxycycline and 3.3, 3.9, 3.9, and 6.4 days for clarithromycin, roxithromycin, erythromycin, and beta-lactams, respectively (P < 0.01 for macrolides versus beta-lactams). We conclude that macrolides may be an adequate empirical antibiotic therapy for acute Q fever.
authors.affiliation: Zoonoses and Clinical Bacteriology, Parasitology, Geographical Medicine, and Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Greece. gikas@med.uoc.gr
authors.forename: A
authors.initials: A
authors.lastname: Gikas
authors.forename: D P
authors.initials: DP
authors.lastname: Kofteridis
authors.forename: A
authors.initials: A
authors.lastname: Manios
authors.forename: J
authors.initials: J
authors.lastname: Pediaditis
authors.forename: Y
authors.initials: Y
authors.lastname: Tselentis
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000032:analysis; D016997:Coxiella burnetii / Q000187:drug effects; D005260:Female; D006801:Humans; D007769:Lactams; D018942:Macrolides; D008297:Male; D008875:Middle Aged; D011778:Q Fever / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D007769:Lactams; D018942:Macrolides