title: Novel oxindole derivatives and their biological activity.
abstract: The antifungal activity of fourteen novel derivatives of oxindole with side chain was studied using representatives of toxinogenic, phytopathogenic and dermatophytic filamentous fungi. Derivatives with exocyclic C=C bond in position C-3 exhibited a higher antifungal activity compared with derivatives with an exocyclic C-C bond in the same position. The strongest antifungal effects were shown by 3-(-2-thienoylmethylidene)-indol-2(3H)-ones.
authors.affiliation: Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia. strigaco@chelin.chtf.stuba.sk
authors.forename: J
authors.initials: J
authors.lastname: Strigácová
authors.forename: D
authors.initials: D
authors.lastname: Hudecová
authors.forename: M
authors.initials: M
authors.lastname: Mikulásová
authors.forename: L
authors.initials: L
authors.lastname: Varecka
authors.forename: A
authors.initials: A
authors.lastname: Lásiková
authors.forename: D
authors.initials: D
authors.lastname: Végh
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects; D020171:Botrytis / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D009152:Mutagenicity Tests; D010084:Oxidation-Reduction; D010407:Penicillium / Q000378:metabolism; D012233:Rhizopus / Q000187:drug effects*; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D007211:Indoles