Chromosomal aberrations in long-haul air crew members.
The increasing use of air travel suggests the need for risk assessment and cytogenetic analysis of flight personnel, to check for the risk of developing cancer. Taking into consideration occupational risk and possible confounding factors, we used traditional cytogenetics, the micronucleus test and fluorescent in situ hybridization (FISH) analysis to study 48 male crew members working on long-haul flights and a control group of 48 ground staff. Compared to controls, we detected a significant increase in the relative risk of gaps and breaks (adjusted odds ratio (OR(adj))--7.8; 95% confidence interval (CI) - 2.4-24.9) and of translocations (OR(adj)--5.1; 95% CI 1.5-17.3) in crew members, with a non-significant difference in the other chromosomal aberrations. The possibility of a correlation between translocations and cancer risk highlights the need for preventive measures for aircraft personnel.
Cavallo
Delia
D
Department of Occupational Medicine, ISPESL-National Institute for Occupational Safety and Prevention, Via Fontana Candida 1, 00040 Monteporzio Catone, Rome, Italy.
Marinaccio
Alessandro
A
Perniconi
Barbara
B
Tomao
Paola
P
Pecoriello
Vittorio
V
Moccaldi
Roberto
R
Iavicoli
Sergio
S
D000337:Aerospace Medicine; D002869:Chromosome Aberrations; D003359:Cosmic Radiation; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D015162:Micronucleus Tests; D009369:Neoplasms / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D014178:Translocation, Genetic