New phenanthridine linkers for the solid-phase synthesis of acid-containing compounds.
Two novel, reusable phenanthridine linkers that use cerium ammonium nitrate as a cleavage reagent are described. These linkers are based on a disubstituted amide and are designed for the release of carboxylic acids but tolerate exposure to acidic, basic, and reductive reaction conditions. Application of these linkers to solid-phase organic synthesis affords products in excellent yields and high purities.
Li
W R
WR
Department of Chemistry, National Central University, Chung-Li, Taiwan 32054, ROC. ch01@ncu.edu.tw
Lin
Y S
YS
Hsu
N M
NM