The influence of microcrystalline cellulose grade on shape and shape distributions of pellets produced by extrusion-spheronization.
In this study, five microcrystalline cellulose (MCC) grades were physically characterized and their extrusion-spheronization behaviours were characterized in terms of water requirements and pellet shape profiles. It was found that the MCC grades differed significantly in the physical properties investigated. Physical properties of MCC were found to influence the water requirement for extrusion-spheronization. MCC grades of higher bulk densities, lower porosities and water retentive capacities required less water to produce pellets of equivalent size. These MCC grades were also found to produce pellets of lower sphericity and wider shape distributions. Packing of MCC particles within the agglomerate played a role in determining amount of water retention and pellet rounding during spheronization. However, there was a limit to the influence of packing density on the rate of pellet rounding because poor packing resulted in higher water retentive capacity, which also limited the rate of rounding.
Koo
O M
OM
Department of Pharmacy, National University of Singapore, Singapore.
Heng
P W
PW
D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry*; D010316:Particle Size; D011208:Powders; D013499:Surface Properties; D013718:Tensile Strength; D014867:Water / Q000737:chemistry
D005079:Excipients; D011208:Powders; D014867:Water; D002482:Cellulose; C109691:microcrystalline cellulose