title: Aggregation of insulin by chlorpromazine.
abstract: Chlorpromazine (CPZ) is known to induce hyperglycaemia and can inhibit insulin secretion in both normal subjects and patients with latent diabetes mellitus. In this study, we have tried to determine a probable mechanism by which CPZ causes hyperglycaemia. It is possible that CPZ causes insulin aggregation by the reduction of disulphide bonds, thereby inactivating insulin and hence causing hyperglycaemia.
authors.affiliation: Protein Chemistry Laboratory, Department of Chemistry, Bose Institute, 93/1 Acharyya Prafulla Chandra Road, 700 009, Calcutta, India. bhattacharyyaj@health.missouri.edu
authors.forename: J
authors.initials: J
authors.lastname: Bhattacharyya
authors.forename: K P
authors.initials: KP
authors.lastname: Das
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology; D002417:Cattle; D002746:Chlorpromazine / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D007328:Insulin / Q000378:metabolism*; D007700:Kinetics
chemical_list: D014150:Antipsychotic Agents; D007328:Insulin; D002746:Chlorpromazine