title: The aetiology and management of irritant diaper dermatitis.
abstract: Irritant diaper dermatitis (IDD) is a common condition caused by the combination of wearing diapers, and incontinence of urine and faeces. The available evidence suggests that maceration of the stratum corneum by water increases susceptibility to frictional damage, and epidermal permeation of irritants. The most important irritants underlying IDD appear to be digestive enzymes persisting in faeces, particularly when these are activated by a high pH.
authors.affiliation: Paediatric Dermatology, Great Ormond Street Hospital for Children, London, UK. AtherD@gosh.nhs.uk
authors.forename: D J
authors.initials: DJ
authors.lastname: Atherton
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications; D003963:Diaper Rash / Q000209:etiology / Q000628:therapy; D005243:Feces; D017276:Friction; D005938:Glucocorticoids; D006801:Humans; D007223:Infant; D007224:Infant Care / Q000379:methods; D007231:Infant, Newborn; D012307:Risk Factors; D014556:Urine
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids