[Nervous tissue protein autoantibodies in hepatolenticular degeneration].
Two novel protein antigens-Hbmp-1 and Hbmp-2 have been isolated from human brain tissue. Test-systems for determining auto-antibodies (a-Ab) to above mentioned proteins, as well as to basic myelin protein, S-100 beta and glial fibrillary acid protein have been developed. Sixty-three HLD patients have been examined. Increased a-Ab levels to the novel proteins has been shown in HLD patients; no difference between HLD patients and control groups being found for a-Ab levels to other proteins. Correlation has been observed between a type and course of the disease, on the one hand, and a-Ab levels to Hbmp-1 and to Hbmp-2, on the other hand.
Morozov
S G
SG
Usanova
M P
MP
Poleshchuk
V V
VV
Poletaev
A V
AV
Ivanova-Smolenskaia
I A
IA
Markova
E D
ED
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology*; D006527:Hepatolenticular Degeneration / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000276:immunology*; D009418:S100 Proteins / Q000276:immunology*
D001323:Autoantibodies; D005904:Glial Fibrillary Acidic Protein; D004676:Myelin Basic Protein; D009418:S100 Proteins; C110294:S100A1 protein