High-dose vitamin B(6) treatment in West syndrome.
Approximately 10-30% of patients with West syndrome respond to high-dose vitamin B(6) treatment. The response to vitamin B(6) is rapid; seizures disappear within the first 2 weeks of treatment. Mild side effects, such as gastrointestinal symptoms and liver dysfunction, are observed in 40-70%, but these resolve after discontinuation or a reduction of the dosage of vitamin B(6). High-dose vitamin B(6) treatment is useful as a first line agent in treating West syndrome.
Toribe
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Y
Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840, Murodo-cho, Izumi, Osaka 594-1101, Japan. toribe@mch.pref.osaka.jp
D004562:Electrocardiography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D013036:Spasms, Infantile / Q000175:diagnosis / Q000188:drug therapy*; D025101:Vitamin B 6 / Q000008:administration & dosage* / Q000009:adverse effects
D025101:Vitamin B 6