title: [Treatment with sodium alginate of gastroesophageal reflux disease in childhood: efficacy and tolerance assessment].
abstract: OBJECTIVE
  Evaluation of efficacy of sodium alginate (Gaviscon) in the treatment of gastroesophageal reflux disease in children 3-12 months old, assessed by 24 hours esophageal continuous pH monitoring.
  
  
  METHODS
  28 children studied by 24 hours pH esophageal continuous monitoring before starting the treatment with Gaviscon 0.5 ml/Kg/dose four times a day, 20 minutes after meal. After 2 months of treatment, a second pH esophageal monitoring was performed, during therapy. Total number of refluxes, number of refluxes longer than 5 minutes and reflux index before and during treatment were evaluated, by multiple regression method.
  
  
  RESULTS
  All pHmetric parameters showed a statistically significative improvement after 60 days of treatment.
authors.affiliation: Istituti Clinici di Perfezionamento, Ospedale dei Bambini V. Buzzi, Divisione di Chirurgia Pediatrica, Via Castelvetro, 32 20154 Milano, Italia. luciano.maestri@tin.it
authors.forename: L
authors.initials: L
authors.lastname: Maestri
mesh_terms: D000464:Alginates / Q000627:therapeutic use*; D000536:Aluminum Hydroxide / Q000627:therapeutic use*; D000863:Antacids / Q000627:therapeutic use*; D004338:Drug Combinations; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D012824:Silicic Acid / Q000627:therapeutic use*; D017693:Sodium Bicarbonate / Q000627:therapeutic use*
chemical_list: D000464:Alginates; D000863:Antacids; D004338:Drug Combinations; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D017693:Sodium Bicarbonate