title: Agranulocytosis and granulocytopenia associated with quetiapine.
abstract: OBJECTIVE
  Quetiapine is a recently introduced atypical antipsychotic. Although adverse effects are mainly mild, more serious infrequent adverse effects including leucopenia are mentioned.
  
  
  METHODS
  We describe three case-reports concerning haematological adverse effects of quetiapine.
  
  
  RESULTS
  Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.
  
  
  CONCLUSIONS
  Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine. Further post-marketing surveys are required.
authors.affiliation: MFO Psychiatrie AMC/de Meren, Academic Medical Centre, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
authors.forename: H G
authors.initials: HG
authors.lastname: Ruhé
authors.forename: H E
authors.initials: HE
authors.lastname: Becker
authors.forename: P
authors.initials: P
authors.lastname: Jessurun
authors.forename: C H
authors.initials: CH
authors.lastname: Marees
authors.forename: M
authors.initials: M
authors.lastname: Heeringa
authors.forename: H D
authors.initials: HD
authors.lastname: Vermeulen
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000175:diagnosis; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003987:Dibenzothiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D000069348:Quetiapine Fumarate; D012563:Schizophrenia, Paranoid / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate