Ultrastructural and biosynthetic characteristics of glomerular endotheliocytes and periglomerular arterioles during systemic lupus erythematosus.
We studied ultrastructural characteristics of renal cortical cells in patients with systemic lupus erythematosus. Endotheliocytes in periglomerular arterioles underwent primary and most pronounced changes. Examination of glomerulocytes revealed early alterations in endotheliocytes, compensatory proliferation of mesangial cells, overproduction of the mesangial matrix, and metaplasia of podocytes. Biosynthetic reactions reflected the structural and functional heterogeneity of endotheliocytes associated with their damages and regeneration.
Chapaeva
N N
NN
Laboratory of Ultrastructural Bases of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the RAMS, Novosibirsk. pathol@cyber.ma.nsc.ru
Nepomnyashchikh
G I
GI
Aidagulova
S V
SV
Bakarev
M A
MA
D000328:Adult; D001160:Arterioles / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D001706:Biopsy; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D005920:Glomerular Mesangium / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008679:Metaplasia