Analysis of the antiviral activities of natural IFN-alpha preparations and their subtype compositions.
Here we report on the antiviral effects of two commercially available natural interferon-alpha (IFN-alpha) preparations, their subtype compositions, and the effects of combinations of pairs of the subtypes on virally infected cells. Our results show that the antiviral effects of these preparations depend on the target cell and on the infecting virus. The component subtypes vary with the preparations, and combinations of pairs of IFN-alpha subtypes may have synergistic or competitive effects. Our results suggest that optimal preparations of synergistically acting subtypes may provide more therapeutic benefit to patients.
Yanai
Y
Y
Fujisaka Institute, Hayashibara Biochemical Laboratories, Inc., Okayama 702-8006, Japan. fujisaki@hayashibara.co.jp
Sanou
O
O
Kayano
T
T
Ariyasu
H
H
Yamamoto
K
K
Yamauchi
H
H
Ikegami
H
H
Kurimoto
M
M
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D004357:Drug Synergism; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007370:Interferon Type I / Q000494:pharmacology; D016898:Interferon-alpha / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D020033:Protein Isoforms / Q000494:pharmacology; D011994:Recombinant Proteins; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000998:Antiviral Agents; D007370:Interferon Type I; D016898:Interferon-alpha; D020033:Protein Isoforms; D011994:Recombinant Proteins