title: Detection of mammaglobin mRNA in the plasma of breast cancer patients.
abstract: It has been suggested that mammaglobin may be a useful marker for breast cancer clinical research. Studies investigating the detection of mRNA by RT-PCR from circulating carcinoma cells in the peripheral blood of breast cancer patients have shown that mammaglobin is a highly specific marker and correlates with several prognostic factors, such as lymph node involvement. We aimed to detect cell-free mammaglobin mRNA in the plasma of breast cancer patients and to investigate whether it can be used as a marker for diagnosis of breast cancer.
authors.affiliation: Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Headington, United Kingdom. shira_gal@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Gal
authors.forename: C
authors.initials: C
authors.lastname: Fidler
authors.forename: Y M
authors.initials: YM
authors.lastname: Lo
authors.forename: K
authors.initials: K
authors.lastname: Chin
authors.forename: J
authors.initials: J
authors.lastname: Moore
authors.forename: A L
authors.initials: AL
authors.lastname: Harris
authors.forename: J S
authors.initials: JS
authors.lastname: Wainscoat
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D060785:Mammaglobin A; D009363:Neoplasm Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000097:blood*; D012334:RNA, Neoplasm / Q000097:blood*; D014598:Uteroglobin / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D060785:Mammaglobin A; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C556448:SCGB2A2 protein, human; D014598:Uteroglobin