Applications of DNA microarrays in microbial systems.
DNA microarray technology allows a parallel analysis of RNA abundance and DNA homology for thousands of genes in a single experiment. Over the past few years, this powerful technology has been used to explore transcriptional profiles and genome differences for a variety of microorganisms, greatly facilitating our understanding of microbial metabolism. With the increasing availability of complete microbial genomes, DNA microarrays are becoming a common tool in many areas of microbial research, including microbial physiology, pathogenesis, epidemiology, ecology, phylogeny, pathway engineering and fermentation optimization.
Ye
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E328/148B, DuPont Experimental Station, DuPont Central Research and Development, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA. rick.ye@usa.dupont.com
Wang
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Bedzyk
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Croker
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D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics*; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D016680:Genome, Bacterial; D023281:Genomics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011387:Prokaryotic Cells; D012313:RNA / Q000235:genetics; D014158:Transcription, Genetic
D004269:DNA, Bacterial; D012313:RNA