title: Stereoselective total synthesis of (+/-)-thielocin A1beta.
abstract: The stereospecific total synthesis of (+/-)-thielocin A1beta has been achieved from the common intermediate ethyl 5-formyl-2,4-dihydroxy-3,6-dimethyl benzoate (8). The racemic synthesis was achieved based on the key reaction of a 4-methyl-3,4-dihydroxy cyclohexadienone 38 with a quinone methide derived at low temperature from the fluoride ion catalyzed composition of piperidinium salt 40. The resulting condensate (31) was homologated by successive esterification with protected monomeric phenol 41 to provide, after careful removal of the protecting groups, the desired thielocin A1beta.
authors.affiliation: Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire-Dorval, Québec, Canada H9R 4P8.
authors.forename: Y
authors.initials: Y
authors.lastname: Génisson
authors.forename: P C
authors.initials: PC
authors.lastname: Tyler
authors.forename: R G
authors.initials: RG
authors.lastname: Ball
authors.forename: R N
authors.initials: RN
authors.lastname: Young
mesh_terms: D000818:Animals; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D051381:Rats; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013582:Synovial Fluid / Q000201:enzymology; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D010726:Phosphodiesterase Inhibitors; D014966:Xanthenes; C072738:thielocin A1beta; D010741:Phospholipases A