Urinary metabolites of genistein administered orally to rats.
In a study on the metabolism of flavonoids, the isoflavone genistein was administered orally to rats. Urine samples were collected and treated with beta-glucuronidase and arylsulfatase. Genistein and its metabolites, 4',5,7-trihydroxyisoflavanone (M1), 4',7-dihydroxyisoflavan (M2), and p-ethylphenol (M3) were isolated from the urine following treatment with enzymes. The structures of M1, M2, and M3 were determined on the basis of chemical and spectral data.
Yasuda
T
T
Tohoku Pharmaceutical University, Sendai, Miyagi, Japan.
Ueda
J
J
Ohsawa
K
K
D000284:Administration, Oral; D000818:Animals; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine; D019833:Genistein / Q000008:administration & dosage* / Q000378:metabolism / Q000652:urine*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D004791:Enzyme Inhibitors; D019833:Genistein