Trans-sodium crocetinate restores blood pressure, heart rate, and plasma lactate after hemorrhagic shock.
BACKGROUND
Trans-sodium crocetinate (TSC) has been shown to increase oxygen consumption during hemorrhagic shock. The current study was done to determine the effect of TSC on other parameters such as blood pressure, heart rate, blood pH, and lactate.


METHODS
A rat model of hemorrhagic shock was used, in which a constant volume of blood is removed.


RESULTS
TSC increased mean arterial blood pressure from a value (immediately after hemorrhage) of 35 mm Hg to a value of 75 mm Hg, and all treated animals survived. In contrast, blood pressure in control animals decreased, with most dying soon after the hemorrhage. TSC also lessened the tachycardia which resulted from the hemorrhage. Blood pH did not decrease as much when TSC was given, and plasma lactate levels were greatly reduced.


CONCLUSIONS
It would appear that TSC is a promising initial treatment for hemorrhagic shock.
Giassi
L J
LJ
Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904-4741, USA. jlg@virginia.edu
Gilchrist
M J
MJ
Graham
M C
MC
Gainer
J L
JL
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002338:Carotenoids / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012771:Shock, Hemorrhagic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D014801:Vitamin A / Q000031:analogs & derivatives
D000975:Antioxidants; D007773:Lactates; C487773:trans-sodium crocetinate; D014801:Vitamin A; D002338:Carotenoids