Koala biovar of Chlamydia pneumoniae infects human and koala monocytes and induces increased uptake of lipids in vitro.
We examined the ability of the koala biovar of Chlamydia pneumoniae to infect both Hep-2 cells and human monocytes and the effect of infection on the formation of foam cells. The koala biovar produced large inclusions in both human and koala monocytes and in Hep-2 cells. Koala C. pneumoniae induced foam cell formation with and without added low-density lipoprotein, in contrast to TW183, which produced increased foam cell formation only in the presence of low-density lipoprotein.
Coles
K A
KA
Departments of Public Health, the University of Western Australia. k.coles@ugrad.unimelb.edu
Timms
P
P
Smith
D W
DW
D000818:Animals; D001692:Biological Transport; D002454:Cell Differentiation; D002478:Cells, Cultured; D016993:Chlamydophila pneumoniae / Q000472:pathogenicity*; D005487:Foam Cells / Q000166:cytology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008394:Marsupialia / Q000382:microbiology*; D009000:Monocytes / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology*; D013045:Species Specificity
D008077:Lipoproteins, LDL