Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick.
It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-beta-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.
Bungo
T
T
Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan. bungo@agr.ehime-u.ac.jp
Kawakami
S I
SI
Ohgushi
A
A
Sashihara
K
K
Saito
N
N
Sugahara
K
K
Hasegawa
S
S
Denbow
D M
DM
Furuse
M
M
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000855:Anorexia / Q000139:chemically induced*; D002645:Chickens; D015259:Dopamine Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005669:Fusaric Acid / Q000494:pharmacology*; D005934:Glucagon / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*
D015259:Dopamine Agents; D010446:Peptide Fragments; D011498:Protein Precursors; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D005669:Fusaric Acid; D009638:Norepinephrine