Structural and functional characteristics of neurons in the sensorimotor cortex of rats with different resistance to emotional stress.
Wistar rats behaviorally active in the open field test (resistant to emotional stress) are characterized by polymorphism of neurons in layer V of the sensorimotor cortex and the presence of hyperchromatic cells, which probably determines resistance to emotional stress in these rats. Atrophy of hyperchromatic neurons reflecting transient inhibition of cell activity was noted in Wistar rats subjected to stress. In the sensorimotor cortex of behaviorally passive animals (predisposed to emotional stress) groups of densely packed hyperchromatic cells and pronounced pericellular edema were revealed. In these rats stress caused irreversible changes in cortical neurons and death of some cells. The presence of ischemic cortical neurons in rats subjected to emotional stress suggests that cerebral hypoxia plays a role in structural and functional disorganization of the sensorimotor cortex during emotional stress.
Bogolepov
N N
NN
Institute of Brain, Russian Academy of Medical Sciences, Moscow.
Koplik
E V
EV
Krivitskaya
G N
GN
Popova
E N
EN
Sudakov
K V
KV
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003672:Defecation; D004558:Electric Stimulation; D008297:Male; D009044:Motor Cortex / Q000473:pathology* / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000473:pathology / Q000502:physiology; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*