title: alpha-Tocopherol modulates liver toxicity of the pyrethroid cypermethrin.
abstract: The objective of the current study was to analyze the hepatotoxic effect caused by cypermethrin (CYP) in rats, and to evaluate the possible protective effect of the antioxidant alpha-tocopherol (alpha-T). Fifty male Wistar rats were given daily i.p. doses of 300 mg/kg per day of CYP during 7 days. Half of them were administered three previous doses of 100 mg/kg per day of alpha-T, followed by seven subsequent oral doses of 40 mg/kg per day of alpha-T. The levels of biochemical indicators and histological liver damage were determined, as well as DCVA in urine. CYP altered the lipid metabolism. Such alterations were inhibited 32% by alpha-T, except for LDL. Alterations in AST were modulated in 29%. In the histology, alpha-T reduced mitochondria damage, and swelling of the endoplasmic reticulum of the liver cells. The results suggest that alpha-T can modify CYP metabolism, changing the lipidic profile and the histological analysis.
authors.affiliation: Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora. Apdo. Postal 1658, Hermosillo, Sonora, Mexico. laldana@guayacan.uson.mx
authors.forename: L
authors.initials: L
authors.lastname: Aldana
authors.forename: V
authors.initials: V
authors.lastname: Tsutsumi
authors.forename: A
authors.initials: A
authors.lastname: Craigmill
authors.forename: M I
authors.initials: MI
authors.lastname: Silveira
authors.forename: E
authors.initials: E
authors.lastname: Gonzalez de Mejia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D007306:Insecticides / Q000633:toxicity*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D008297:Male; D011722:Pyrethrins / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D024502:alpha-Tocopherol / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D007306:Insecticides; D008055:Lipids; D011722:Pyrethrins; C017160:cypermethrin; D024502:alpha-Tocopherol