title: [Nervous tissue protein autoantibodies in hepatolenticular degeneration].
abstract: Two novel protein antigens-Hbmp-1 and Hbmp-2 have been isolated from human brain tissue. Test-systems for determining auto-antibodies (a-Ab) to above mentioned proteins, as well as to basic myelin protein, S-100 beta and glial fibrillary acid protein have been developed. Sixty-three HLD patients have been examined. Increased a-Ab levels to the novel proteins has been shown in HLD patients; no difference between HLD patients and control groups being found for a-Ab levels to other proteins. Correlation has been observed between a type and course of the disease, on the one hand, and a-Ab levels to Hbmp-1 and to Hbmp-2, on the other hand.
authors.forename: S G
authors.initials: SG
authors.lastname: Morozov
authors.forename: M P
authors.initials: MP
authors.lastname: Usanova
authors.forename: V V
authors.initials: VV
authors.lastname: Poleshchuk
authors.forename: A V
authors.initials: AV
authors.lastname: Poletaev
authors.forename: I A
authors.initials: IA
authors.lastname: Ivanova-Smolenskaia
authors.forename: E D
authors.initials: ED
authors.lastname: Markova
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology*; D006527:Hepatolenticular Degeneration / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000276:immunology*; D009418:S100 Proteins / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D005904:Glial Fibrillary Acidic Protein; D004676:Myelin Basic Protein; D009418:S100 Proteins; C110294:S100A1 protein