Parallel electrosynthesis of 1,2-diamines.
Parallel reductive hydrocoupling of aldimines was performed to generate vicinal diamines using the spatially addressable electrolysis platform (SAEP). The stainless steel cathodes and sacrificial aluminum anodes were used in this electrosynthesis methodology. Introducing a large substituent on the imino nitrogen atom efficiently controls stereoselectivity of the electroreductive coupling process. This method can now be applied to the generation of libraries of 1,2-diamines, which further expands the techniques of parallel synthesis and combinatorial electrochemistry.
Siu
T
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Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
Li
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W
Yudin
A K
AK
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003959:Diamines / Q000138:chemical synthesis*; D004563:Electrochemistry; D007097:Imines / Q000737:chemistry
D003959:Diamines; D007097:Imines