title: Separation and NMR studies on lignans of Raulinoa echinata.
abstract: Investigation of the leaves of Raulinoa echinata Cowan (Rutaceae) has led to the isolation of several furofuran (2,6-diaryl-3,7-dioxabicyclo[3.3.0]-octane) lignan derivatives, namely (+)-sesamin, (+)-eudesmin, (+)-methylpiperitol (= kobusin), (+)-piperitol-gamma,gamma-dimethylallylether and the corresponding epi compounds: (+)-asarinin, (+)-epieudesmin, (+)-methylxanthoxylol, (+)-methylpluviatilol, (+)-xanthoxylol-gamma,gamma-dimethylallylether and (+)-pluviatilol-gamma,gamma-dimethylallylether. This is the first report of the chromatographic separation of the epimers (+)-methylxanthoxylol/(+)-methylpluviatilol and (+)-xanthoxylol-gamma,gamma-dimethylallylether/(+)-pluviatilol-gamma,gamma- dimethylallylether and of their NMR nOe difference studies.
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP, Brazil.
authors.forename: M W
authors.initials: MW
authors.lastname: Biavatti
authors.forename: P C
authors.initials: PC
authors.lastname: Vieira
authors.forename: M F
authors.initials: MF
authors.lastname: da Silva
authors.forename: J B
authors.initials: JB
authors.lastname: Fernandes
authors.forename: A L
authors.initials: AL
authors.lastname: Degani
authors.forename: Q B
authors.initials: QB
authors.lastname: Cass
authors.forename: A B
authors.initials: AB
authors.lastname: Schefer
authors.forename: A G
authors.initials: AG
authors.lastname: Ferreira
mesh_terms: D004149:Dioxoles / Q000032:analysis / Q000737:chemistry; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification; D017705:Lignans / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010944:Plants / Q000737:chemistry*
chemical_list: D004149:Dioxoles; D005663:Furans; D017705:Lignans; D010636:Phenols; C442492:methylpluviatilol; C442491:methylxanthoxylol; C054125:sesamin