title: Liver pathology in children with AIDS: a comparison between the South American and North American population.
abstract: Liver tissue from autopsies of twenty-nine cases of children with AIDS were collected from three major South America (S.4) pediatric hospitals. The hepatopathologic findings were classified in the same fashion as in a series of sixty-one children with AIDS from North America (NA): inflammation, non-specific, lymphoproliferative disorders, and giant cell transformation. By comparing both groups. we noted that the SA children were Younger at time of death consistent with a more rapid progression of the disease. Opportunistic infections varied with a higher prevalence of Cytomegalovirus (CMV) infection in SA children. The histopathologic features of CMV in the liter of SA children were associated with a conspicuous inflammation absent in the NA group. Finally, different non-specific hepatic changes were found in SA children, including one case of peliosis hepatis.
authors.affiliation: Department of Pathology, New York University Medical Center, New York, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Morotti
authors.forename: M
authors.initials: M
authors.lastname: Tata
authors.forename: R
authors.initials: R
authors.lastname: Drut
authors.forename: S
authors.initials: S
authors.lastname: Siminovich
authors.forename: D
authors.initials: D
authors.lastname: Menezes
authors.forename: M C
authors.initials: MC
authors.lastname: Guitierrez
authors.forename: E
authors.initials: E
authors.lastname: Kahn
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology*; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications / Q000473:pathology; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000150:complications / Q000473:pathology; D008297:Male; D009656:North America; D013020:South America