Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats.
Behavioral effects of the aqueous extract of Guiera senegalensis on the central nervous system of mice and rats were investigated. Spontaneous motor activity, pentobarbital sleeping time, amphetamine-stereotyped behavior, exploratory activity and performance on treadmills (rota-rod) were evaluated. The results revealed that the aqueous extract of G. senegalensis reduced spontaneous motor activity in mice, prolonged the duration of pentobarbital sleeping time in rats and attenuated amphetamine-induced stereotype behavior in rats. The extract also decreased exploratory activity in mice and had no observable effects on motor coordination (rota-rod) at the doses tested. The results suggested that the crude aqueous extract of G. senegalensis possesses some biologically active principles that are sedative in nature.
Amos
S
S
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, FCT, Nigeria. samsonamos@yahoo.co.uk
Kolawole
E
E
Akah
P
P
Wambebe
C
C
Gamaniel
K
K
D000661:Amphetamine / Q000008:administration & dosage; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D029764:Combretaceae; D005106:Exploratory Behavior / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000008:administration & dosage; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D010936:Plant Extracts; D000661:Amphetamine; D010424:Pentobarbital