title: Postural control and glycerol test in Ménière's disease.
abstract: Ménière's disease is a clinical disorder, characterized by fluctuating hearing loss, recurrent spontaneous episodic vertigo, tinnitus and aural fullness, which may be defined as the idiopathic syndrome of endolymphatic hydrops. The most important test for diagnosis of Ménière's disease is the glycerol test. This is a simple and rapid method and several authors have confirmed its efficiency for identifying endolymphatic hydrops. This test provides information on the cochlear response to the osmotic changes produced by glycerol in the inner ear, whereas modifications in the vestibular labyrinth are usually not evaluated. The aim of this study was to evaluate the effects of glycerol on postural control during attacks of Ménière's disease, and to correlate this data with data on cochlear function. After the glycerol test, an improvement in postural control was recorded in 70% of patients, with all patients reporting a recovery of vertigo. The impairment of postural control during endolymphatic hydrops could be related to a pressure increase in the labyrinth, which interferes with the normal dynamics of the endolymph, and a rapid functional recovery could occur during an osmotic depletion. Dynamic posturography improves the sensitivity of the glycerol test and may therefore be useful in the diagnosis and staging of Ménière's disease.
authors.affiliation: Institute of Otorhinolaryngology, Catholic University of Rome, Italy. sdigirolamo@rm.unicatt.it
authors.forename: S
authors.initials: S
authors.lastname: Di Girolamo
authors.forename: P
authors.initials: P
authors.lastname: Picciotti
authors.forename: B
authors.initials: B
authors.lastname: Sergi
authors.forename: A
authors.initials: A
authors.lastname: D'Ecclesia
authors.forename: W
authors.initials: W
authors.lastname: Di Nardo
mesh_terms: D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D003451:Cryoprotective Agents; D005260:Female; D005990:Glycerol; D006319:Hearing Loss, Sensorineural / Q000453:epidemiology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008875:Middle Aged; D011187:Posture; D012044:Regression Analysis; D012720:Severity of Illness Index; D014717:Vertigo / Q000453:epidemiology / Q000534:rehabilitation
chemical_list: D003451:Cryoprotective Agents; D005990:Glycerol