title: Perioperative care of children with nerve agent intoxication.
abstract: Nerve agents (NA) present a major threat to civilian populations. When a ballistic system is used for spreading poison, multiple trauma, as well as toxic trauma could be caused. Children are more susceptible, due to their smaller physiological reserve. Urgent surgical intervention for combined intoxication in the multiple-traumatized child could be a tremendous task in view of the background of physiological instability. Nerve agents affect the autonomic, as well as the central nervous system, leading occasionally to unexpected interactions with agents normally used for resuscitation. This can cause additional instability, and possibly systemic collapse. This review presents and emphasizes points concerning treatment of a child who suffers from combined multiple and toxic traumas. The review is based on scant knowledge of a database of similar cases of pesticide organophosphate poisoning in children since these compounds are alike. We also extrapolated data from reports concerning episodic civilian exposure to NA.
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Post-Anaesthesia Care Unit, Tel-Aviv Sourasky Medical Centre, Tel-Aviv University, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Ben Abraham
authors.forename: A A
authors.initials: AA
authors.lastname: Weinbroum
authors.forename: V
authors.initials: V
authors.lastname: Rudick
authors.forename: G
authors.initials: G
authors.lastname: Paret
mesh_terms: D000931:Antidotes / Q000627:therapeutic use; D002491:Central Nervous System Agents / Q000506:poisoning*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D002648:Child; D006801:Humans; D007430:Intraoperative Care; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*
chemical_list: D000931:Antidotes; D002491:Central Nervous System Agents; D002619:Chemical Warfare Agents