TT dinucleotides containing an isoxazoline moiety: synthesis and binding affinity study.
We have prepared four diastereomers of TT dinucleotides containing an isoxazoline moiety and four dodecanucleotides incorporating these TT dinucleotides in the middle of the DNA sequence. We also have determined the melting temperatures of these modified oligonucleotides (Tm values) by measuring change in UV absorbance.
Kong
J R
JR
Department of Chemistry, Center for Integrated Molecular Systems, Pohang University of Science and Technology, Pohang, Korea.
Kim
S K
SK
Moon
B J
BJ
Kim
S J
SJ
Kim
B H
BH
D007555:Isoxazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D013053:Spectrophotometry; D013696:Temperature; D013941:Thymine / Q000737:chemistry; D014466:Ultraviolet Rays
D007555:Isoxazoles; D009711:Nucleotides; D013941:Thymine