Intracranial aneurysms in Ehlers-Danlos syndrome type IV in early childhood.
Ehlers-Danlos syndrome type IV is of special interest to neurologists because of the risk of cerebrovascular complications. We describe a 5-year-old female with Ehlers-Danlos syndrome type IV, demonstrating multiple intracranial aneurysms and right middle cerebral artery stenosis. The diagnosis of Ehlers-Danlos syndrome type IV was confirmed by electron microscopic examination of a skin biopsy. To our knowledge, this is the youngest reported patient with intracranial aneurysms associated with the Ehlers-Danlos syndrome type IV. Ehlers-Danlos syndrome type IV should be considered in the differential diagnosis of cerebrovascular disorder and stroke in early childhood.
Kato
T
T
Department of Pediatrics, Faculty of Medicine, Kyoto University, Kyoto, Japan.
Hattori
H
H
Yorifuji
T
T
Tashiro
Y
Y
Nakahata
T
T
D017668:Age of Onset; D001706:Biopsy; D002561:Cerebrovascular Disorders / Q000175:diagnosis; D002675:Child, Preschool; D003251:Constriction, Pathologic; D003937:Diagnosis, Differential; D004535:Ehlers-Danlos Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000209:etiology* / Q000473:pathology; D018810:Magnetic Resonance Angiography; D020768:Middle Cerebral Artery / Q000473:pathology*; D012867:Skin / Q000473:pathology*