Internal use of n-butyl 2-cyanoacrylate (Indermil) for wound closure: an experimental study.
n-Butyl 2-cyanoacrylate glue (Indermil) was used for the closure of dorsal wounds on rabbits. A 4-cm-long and 1-cm-wide laceration was created bilaterally on the back of 15 rabbits. One side was closed with absorbable 2-0 subcutaneous sutures and fast absorbable 3-0 skin sutures, whereas the other side was closed with cyanoacrylate glue applied on both deep and superficial tissues. A partial wound dehiscence occurred on the glue side in one animal at 2 weeks. The animal was killed at this time and considered a bad result in the glue group. In all other animals, no seroma, partial dehiscence, or wound infection occurred. Histopathologic analysis revealed that Indermil induced edema and a mild acute inflammatory reaction and resorbed almost completely within 2 months when applied to well-vascularized tissues. The application of glue on the cutaneous wound edges is a fast and easy procedure that does not seem to delay or inhibit the healing process or its quality.
Pelissier
P
P
Service de Chirurgie Plastique, Hôpital Pellegrin-Tondu, Bordeaux, France.
Casoli
V
V
Le Bail
B
B
Martin
D
D
Baudet
J
J
D000818:Animals; D062109:Dermatologic Surgical Procedures; D004659:Enbucrilate / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D011817:Rabbits; D012867:Skin / Q000293:injuries / Q000473:pathology; D013537:Sutures; D014014:Tissue Adhesives / Q000008:administration & dosage* / Q000009:adverse effects; D014945:Wound Healing / Q000187:drug effects
D014014:Tissue Adhesives; D004659:Enbucrilate