Late opacification of the foldable hydrophilic acrylic lens SC60B-OUV.
OBJECTIVE
To investigate the cause of severe central opacification in 41 foldable acrylic intraocular lenses (IOLs) requiring explantation. Another IOL was opacified in the original sealed vial.


METHODS
Case series and laboratory analysis.


METHODS
Light microscopy, high performance liquid chromatography, sodium dodecyl sulfate polyacoylamide gel electrophoresis, spectrometric analysis, and autoclaving.


RESULTS
Neither fatty acids nor proteins could be identified within the IOLs. Spectrometric analysis yielded absorption peaks in the ultraviolet spectral range.


CONCLUSIONS
The spectroscopic findings indicate premature aging of the ultraviolet blocking agent. The source of the opacification is a change in the IOL material itself.
Frohn
A
A
University Eye Hospital Tuebingen, Tuebingen, Germany. andreas.frohn@t-online.de
Dick
H B
HB
Augustin
A J
AJ
Grus
F H
FH
D000180:Acrylic Resins / Q000737:chemistry; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D020878:Device Removal; D004591:Electrophoresis, Polyacrylamide Gel; D005136:Eye Proteins / Q000032:analysis; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D006801:Humans; D007910:Lenses, Intraocular; D008297:Male; D011475:Prosthesis Failure
D000180:Acrylic Resins; D005136:Eye Proteins; D005227:Fatty Acids