title: n-Hexane-related peripheral neuropathy among automotive technicians--California, 1999-2000.
abstract: Solvents, glues, spray paints, coatings, silicones, and other products contain normal (n-) hexane, a petroleum distillate and simple aliphatic hydrocarbon. n-Hexane is an isomer of hexane and was identified as a peripheral neurotoxin in 1964. Since then, many cases of n-hexane-related neurotoxicity have occurred in printing plants, sandal shops, and furniture factories in Asia, Europe, and the United States. This report describes an investigation of n-hexane-associated peripheral neuropathy in an automotive technician, an occupation in which this condition has not been reported, and summarizes the results of two other case investigations in the automotive repair industry. The findings suggest that solvent manufacturers should avoid using hexane when producing automotive degreasing products, and automotive technicians should avoid regular contact with hexane-based cleaning solvents.
mesh_terms: D000328:Adult; D001336:Automobiles; D002140:California / Q000453:epidemiology; D006586:Hexanes / Q000506:poisoning*; D006801:Humans; D008297:Male; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000453:epidemiology; D012997:Solvents / Q000506:poisoning
chemical_list: D006586:Hexanes; D012997:Solvents; C026385:n-hexane