title: Evolutionary perspective on innate immune recognition.
abstract: Analysis of human and Drosophila genomes demonstrates an ancient origin of innate immunity and the diversity of the mechanisms of innate immune recognition.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
authors.forename: A
authors.initials: A
authors.lastname: Mushegian
authors.forename: R
authors.initials: R
authors.lastname: Medzhitov
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D005075:Biological Evolution; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism; D004330:Drosophila / Q000235:genetics* / Q000276:immunology; D029721:Drosophila Proteins; D015894:Genome, Human; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D053474:Nod1 Signaling Adaptor Protein; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; C119067:NOD1 protein, human; D053474:Nod1 Signaling Adaptor Protein; D011956:Receptors, Cell Surface; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; C495341:tehao protein, Drosophila