Metaplastic carcinoma of the breast: p53 analysis identified the same point mutation in the three histologic components.
A rare case of metaplastic carcinoma of the breast with both squamous metaplasia and cartilaginous metaplasia was reported. Histologically, the neoplasm revealed complex features, which were consisting of invasive ductal carcinoma, squamous carcinomatous component and chondrosarcomatoid component. Gradual transition of each component was recognized microscopically. p53 mutation analysis disclosed the same point mutation in three histologically different components, but not in the normal epithelium. Based on the morphologic findings, immunohistochemical findings and the p53 mutation analysis, we concluded that these three components in the tumor originated from the same duct progenitor cells.
Wang
X
X
Department of Pathology, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Japan 641-0012. wang-xj@mail.wakayama-med.ac.jp
Mori
I
I
Tang
W
W
Yang
Q
Q
Nakamura
M
M
Nakamura
Y
Y
Sato
M
M
Sakurai
T
T
Kennichi
K
K
D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002813:Chondrosarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008679:Metaplasia; D008875:Middle Aged; D017354:Point Mutation; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000235:genetics
D004273:DNA, Neoplasm; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53