title: A new Smurf in the village.
abstract: TGF-beta signaling is modulated by Smurfs, E3-ubiquitin ligases that selectively target the receptors and Smad proteins for degradation. New evidence from Drosophila suggests that Smurfs regulate the amplitude and the duration of the cellular response to signaling in vivo.
authors.affiliation: Department of Developmental and Cell Biology, University of California, Irvine 92697, USA.
authors.forename: K
authors.initials: K
authors.lastname: Arora
authors.forename: R
authors.initials: R
authors.lastname: Warrior
mesh_terms: D000818:Animals; D004330:Drosophila / Q000378:metabolism*; D029721:Drosophila Proteins; D008025:Ligases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases
chemical_list: D029721:Drosophila Proteins; D016212:Transforming Growth Factor beta; C492378:Smurf protein, Drosophila; D044767:Ubiquitin-Protein Ligases; D008025:Ligases