Combination of drugs elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bone marrow after 5-fluorouracil treatment.
Combined administration of drugs elevating extracellular adenosine, namely dipyridamole and adenosine monophosphate, together with granulocyte colony-stimulating factor was shown to enhance granulopoietic recovery in the bone marrow of mice treated with 5-fluorouracil. Enhanced regeneration was found both at the level of hematopoietic progenitor cells for granulocytes and macrophages and in the compartment of morphologically recognizable granulocyte precursors. The results might have positive clinical impact. The adjunct use of drugs elevating extracellular adenosine might reduce the cost expenditure of therapy with granulocyte colony-stimulating factor.
Hofer
M
M
Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno. hofer@ibp.cz
Pospísil
M
M
Weiterová
L
L
Znojil
V
V
Vácha
J
J
Holá
J
J
Vacek
A
A
Pipalová
I
I
D000241:Adenosine / Q000378:metabolism*; D000249:Adenosine Monophosphate / Q000008:administration & dosage; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D004176:Dipyridamole / Q000008:administration & dosage; D004347:Drug Interactions; D005110:Extracellular Space / Q000378:metabolism; D005472:Fluorouracil / Q000494:pharmacology*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006098:Granulocytes; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D008264:Macrophages; D008297:Male; D051379:Mice; D011994:Recombinant Proteins / Q000008:administration & dosage
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000249:Adenosine Monophosphate; D004176:Dipyridamole; D000241:Adenosine; D005472:Fluorouracil