title: Two routes to [11C-carbonyl]organo-isocyanates utilizing [11C]phosgene ([11C]organo-isocyanates from [11C]phosgene).
abstract: Two generic radiosynthetic routes for the preparation of [11C-carbonyl]isocyanates have been developed. Reaction of N-organo-sulfinylamines; RNSO, (R = Me, Et, allyl, cyclohexyl and phenyl) with [11C]phosgene gave the corresponding [11C-carbonyl]isocyanates in good radiochemical yield (53-68%) from [11C]phosgene (decay corrected) in ca 16 min from EOB. Alternatively, the reaction of [11C]phosgene with N,N'-organo-ureas; (RNH)(2)CO, (R = Me, Et, Pr and phenyl) also gave the corresponding [11C-carbonyl]isocyanates in moderate radiochemical yield (9-37%) from [11C]phosgene (decay corrected) in ca 16 min from EOB. For identification, the [11C-carbonyl]organo-isocyanates were derivatized with 1-(2-methoxyphenyl)piperazine in situ to [11C-carbonyl]carboxamides and the position of radiolabelling in the carbonyl group confirmed by [11/13C]co-labeling and subsequent carbon-13 NMR spectroscopy.
authors.affiliation: MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. gavin.brown@ic.ac.uk
authors.forename: G D
authors.initials: GD
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Henderson
authors.forename: C
authors.initials: C
authors.lastname: Steel
authors.forename: S
authors.initials: S
authors.lastname: Luthra
authors.forename: P M
authors.initials: PM
authors.lastname: Price
authors.forename: F
authors.initials: F
authors.lastname: Brady
mesh_terms: D002250:Carbon Radioisotopes; D002851:Chromatography, High Pressure Liquid; D017953:Isocyanates / Q000138:chemical synthesis* / Q000737:chemistry; D007553:Isotope Labeling; D010705:Phosgene / Q000737:chemistry
chemical_list: D002250:Carbon Radioisotopes; D017953:Isocyanates; D010705:Phosgene