The shape of things to come: regulation of shape changes in endoplasmic reticulum.
Shape changes in the endoplasmic reticulum control fundamental cell processes including nuclear envelope assembly in mitotic cells, calcium homeostasis in cytoplasmic domains of secreting and motile cells, and membrane traffic in the early secretion apparatus between the endoplasmic reticulum and Golgi. Opposing forces of assembly (membrane fusion) and disassembly (membrane fragmentation) ultimately determine the size and shape of this organelle. This review examines some of the regulatory mechanisms involved in these processes and how they occur at specific sites or subcompartments of the endoplasmic reticulum.
Paiement
J
J
Département de pathologie et biologie cellulaire, Faculté de médecine, Université de Montreal, QC, Canada. paiemej@patho.umontreal.ca
Bergeron
J
J
D000818:Animals; D002474:Cell-Free System; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D007425:Intracellular Membranes / Q000378:metabolism; D008561:Membrane Fusion; D008938:Mitosis; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D051381:Rats