title: A potential source of false-positive sentinel nodes: immunostain misadventure.
abstract: The clinical and pathologic aspects of sentinel lymph node biopsy have generated much attention. Pitfalls in the pathologic handling of sentinel lymph node specimens have received little attention. We report a case in which a false-positive diagnosis might have been rendered on a sentinel lymph node because of an inadvertent immunostaining error. Attention was drawn to the problem by an unusual pattern of distribution of immunoreactive cells-which proved to be plasma cells rather than metastatic carcinoma cells.
authors.affiliation: Department of Pathology, New York Presbyterian Hospital & Weill Medical College of Cornell University, New York, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Chiu
authors.forename: S A
authors.initials: SA
authors.lastname: Hoda
authors.forename: D X
authors.initials: DX
authors.lastname: Yao
authors.forename: P P
authors.initials: PP
authors.lastname: Rosen
mesh_terms: D000906:Antibodies; D000918:Antibody Specificity; D001943:Breast Neoplasms / Q000473:pathology*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007202:Indicators and Reagents; D007633:Keratins / Q000032:analysis; D008875:Middle Aged; D021701:Sentinel Lymph Node Biopsy / Q000379:methods / Q000592:standards
chemical_list: D000906:Antibodies; D007202:Indicators and Reagents; D007633:Keratins