Modelling the human immune response: can mice be trusted? Commentary.
The mouse is now the animal of choice for laboratory-based medical research. Although its contribution to advancing understanding of our inner workings is indisputable, we should acknowledge that mice and humans are tangibly different. This article highlights, and attempts some rationale for, discrepancies between the two species' immune systems.
Gordon
J
J
MRC Centre for Immune Regulation, The Medical School, Birmingham, UK. j.gordon@bham.ac.uk
Grafton
G
G
Wood
P M
PM
Larché
M
M
Armitage
R J
RJ
D000818:Animals; D001249:Asthma / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007109:Immunity / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D013045:Species Specificity; D016615:Telomere / Q000502:physiology