Chromosome cohesion and segregation in mitosis and meiosis.
The faithful segregation of the genetic material into daughter cells during cell division is crucial for the production of healthy progeny. Sister chromatid cohesion and separation are fundamental to this process. Progress has been made in our molecular understanding of cohesion and mechanisms for the dissolution of cohesion have been uncovered.
Uhlmann
F
F
Chromosome Segregation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. f.uhlmann@icrf.icnet.uk
D000818:Animals; D018797:Cell Cycle Proteins; D002842:Chromatids / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone; D020090:Chromosome Segregation; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism; D005656:Fungal Proteins; D006801:Humans; D046911:Macromolecular Substances; D008540:Meiosis; D008938:Mitosis; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000502:physiology; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D005656:Fungal Proteins; D046911:Macromolecular Substances; D009687:Nuclear Proteins; D000097722:Cohesins