title: Immunophenotypic profile and FISH analysis in a case of Ewing's sarcoma.
abstract: Ewing's sarcoma arising in the right fibula was diagnosed in a 12 years old female, considering clinical presentation, radiological findings and histological features. Our work points towards a possible neuroectodermal origin of Ewing's sarcoma, since MIC2/12E7 marker was found to be positive. Translocation t (11;22) (q24;q12) was found as the main cytogenetic change in this tumor, by means of FISH analysis.
authors.affiliation: Department of Pathology, Democritus University of Thrace, Dragana, 68 100 Alexandroupolis, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Papadopoulos
authors.forename: D
authors.initials: D
authors.lastname: Tamiolakis
authors.forename: M
authors.initials: M
authors.lastname: Lambropoulou
authors.forename: G
authors.initials: G
authors.lastname: Alexiadis
authors.forename: P
authors.initials: P
authors.lastname: Argyropoulou
authors.forename: J
authors.initials: J
authors.lastname: Manavis
authors.forename: D
authors.initials: D
authors.lastname: Verettas
authors.forename: E
authors.initials: E
authors.lastname: Sivridis
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000032:analysis; D019070:Cell Lineage; D002648:Child; D002880:Chromosomes, Human, Pair 11 / Q000648:ultrastructure*; D002892:Chromosomes, Human, Pair 22 / Q000648:ultrastructure*; D005260:Female; D005360:Fibula / Q000737:chemistry / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008279:Magnetic Resonance Imaging; D014411:Neoplastic Stem Cells / Q000737:chemistry; D017599:Neuroectodermal Tumors / Q000737:chemistry; D012512:Sarcoma, Ewing / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D016708:Synaptophysin / Q000032:analysis; D014178:Translocation, Genetic; D014746:Vimentin / Q000032:analysis
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D016708:Synaptophysin; D014746:Vimentin