Frontal lobe dysfunction in long-term cannabis users.
This study examined the neurophysiological effects of cannabis. Cerebral blood flow (CBF) was measured in 12 long-term cannabis users shortly after cessation of cannabis use (mean 1.6 days). The findings showed significantly lower mean hemispheric blood flow values and significantly lower frontal values in the cannabis subjects compared to normal controls. The results suggest that the functional level of the frontal lobes is affected by long-term cannabis use.
Lundqvist
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Division of Medical Neurochemistry, Lund University Hospital, 221 85, Lund, Sweden. thomas.lundqvist@labmed.lu.se
Jönsson
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Warkentin
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D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005625:Frontal Lobe / Q000098:blood supply / Q000503:physiopathology*; D006801:Humans; D002189:Marijuana Abuse / Q000503:physiopathology*; D012016:Reference Values; D012039:Regional Blood Flow