Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.
The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.
Olafsdóttir
B R
BR
deCODE genetics Inc, Reykjavík, Iceland.
Rye
D B
DB
Scammell
T E
TE
Matheson
J K
JK
Stefánsson
K
K
Gulcher
J R
JR
D000328:Adult; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D003431:Cross-Cultural Comparison; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007055:Iceland; D047908:Intracellular Signaling Peptides and Proteins; D007438:Introns; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000175:diagnosis / Q000235:genetics*; D009479:Neuropeptides / Q000235:genetics*; D064446:Orexin Receptors; D000068797:Orexins; D011110:Polymorphism, Genetic; D011498:Protein Precursors / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide / Q000235:genetics; D014481:United States
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D064446:Orexin Receptors; D000068797:Orexins; D011498:Protein Precursors; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide