title: [Initial subretinal localization of acute myeloblastic leukemia (AML5) recurrence].
abstract: BACKGROUND
  Reduced visual acuity in patients with acute leucemia can result from many causes including an ocular localization.
  
  
  METHODS
  A patient previously treated for acute myeloblastic leucemia-5 (AML5) developed bilateral vision impairment related to a subretinal localization of the leucemia. Meningeal and bone marrow relapse followed. The subretinal localization responded only to massive systemic steroid treatment.
  
  
  CONCLUSIONS
  Although asymptomatic, ocular localizations are frequent in leucemia. Their prognostic impact depends on the ocular structure involved and on the chronology of onset--early or late in the leucemia course. The underlying pathophysiological mechanism of ocular involvement remains unexplained but hyperleucocytosis at presentation may be a risk factor and would justify at least systematic specialized examinations and discussion of prophylactic treatment.
authors.affiliation: Service d'Hématologie, CHU Angers, Paris.
authors.forename: S
authors.initials: S
authors.lastname: Le Gall
authors.forename: S
authors.initials: S
authors.lastname: François
authors.forename: N
authors.initials: N
authors.lastname: Urier
authors.forename: F
authors.initials: F
authors.lastname: Genevieve
authors.forename: F
authors.initials: F
authors.lastname: d'Hermies
authors.forename: P
authors.initials: P
authors.lastname: Rachieru
authors.forename: N
authors.initials: N
authors.lastname: Ifrah
mesh_terms: D000328:Adult; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000150:complications*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000150:complications; D019572:Retinal Neoplasms / Q000150:complications*; D015354:Vision, Low / Q000209:etiology*