Molecular cloning and sequence analysis of a human untranslated Alu-containing RNA.
A cDNA, designated LNX1, has been identified by subtractive hybridization on the basis that it is expressed in normal human prostate but not in LNCaP cells. Sequence analysis revealed that it contained two Alu repetitive sequences but no long open reading frame. Hence, it belongs to a class of untranslated Alu-containing RNAs. LNX1 is expressed in most tissues. It is encoded by a single copy gene, which is localized on human chromosome 14.
Kwok
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Department of Pathology and Laboratory Medicine, Albert Einstein Medical Center, 5501 Old York Road, Korman 214, Philadelphia, PA 19141-3098, USA. kwoks@aehn2.einstein.edu
Daskal
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D020087:Alu Elements; D001483:Base Sequence; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011247:Pregnancy; D014018:Tissue Distribution; D020506:Untranslated Regions / Q000235:genetics*
D018076:DNA, Complementary; D020506:Untranslated Regions