EBV-associated Hodgkin's disease in an HIV-infected child presenting with a hemophagocytic syndrome.
An 8-years-old boy was admitted with fever of unknown origin, cervical lymphadenopathy and hepatosplenomegaly and weight loss. His mother's HIV infection was diagnosed two weeks before his hospitalization, so he was diagnosed as perinatally acquired AIDS. Serology and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confirmed on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin's disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry on the lymph node biopsy established the EBV association. On the basis of a sequence of appearance of the clinical, laboratory and histological signs, HIV, EBV or HD may have triggered HS as the last fatal event in this pediatric patient.
Preciado
M V
MV
Laboratory of Virology, Ricardo Gutiérrez Children Hospital, Gallo 1330, 1425 Ciudad de Buenos Aires, Argentina. preciado@conicet.gov.ar
De Matteo
E
E
Fallo
A
A
Chabay
P
P
Drelichman
G
G
Grinstein
S
S
D002648:Child; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D017809:Fatal Outcome; D015497:HIV-1; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology* / Q000821:virology; D006689:Hodgkin Disease / Q000150:complications* / Q000821:virology; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000150:complications*; D008297:Male