Injury- and use-related plasticity in adult auditory cortex.
After restricted cochlear lesions in adult animals the frequency selectivity of neurons in the cortical region deprived of its normal input by the lesion is changed such that the region is occupied by expanded representations of adjacent (perilesion) frequencies. These changes reflect a dynamic process of reorganization (plasticity) and are not explicable as passive consequences of the lesion. Analogous plasticity of cortical frequency selectivity and organization is seen following behavioural training that enhances the significance of particular acoustic stimuli. The occurrence of injury- and use-related auditory cortical plasticity gives rise to a number of questions relating to the mechanisms involved, the perceptual consequences and functional significance of such plastic changes, and their implications for the central processing of input from prosthetic devices. Evidence relating to these issues is briefly summarized in this review, and the directions of future research are considered.
Irvine
D R
DR
Department of Psychology, PO Box 17, Monash University, Clayton, Victoria 3800, Australia. d.irvine@sci.monash.edu.au
Rajan
R
R
Brown
M
M
D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D003051:Cochlea / Q000293:injuries* / Q000503:physiopathology*; D004193:Discrimination Learning / Q000502:physiology; D004777:Environment; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology