Neurotransmitter release mechanisms in sympathetic neurons: past, present, and future perspectives.
In 1969, Paton and Vizi described the inhibitory actions of noradrenaline on acetylcholine release from the innervation of the guinea-pig ileum longitudinal muscle. They concluded "that acetylcholine output by the nervous networks of the longitudinal strip is under the normal control of the sympathetic by a species of presynaptic inhibition mediated by <==> receptors". This work was carried out in the Pharmacology Department at Oxford University. Clearly, a period in the 'Dreaming Spires' of Oxford sufficiently inspired Sylvester to take up a life long career in scientific research. He has published more than 300 papers on a wide range of topics but clearly has a strong interest in neurotransmitter release mechanisms and recently, non-synaptic interactions between neurons. It seems fitting therefore to write a brief review on the continuing studies on neurotransmitter release mechanisms in sympathetic neurons in a volume honoring the now distinguished Professor Vizi.
Jackson
V M
VM
Department of Pharmacology, Oxford, UK.
Cunnane
T C
TC
D000818:Animals; D019706:Excitatory Postsynaptic Potentials; D008297:Male; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D014649:Vas Deferens / Q000294:innervation
D018377:Neurotransmitter Agents