title: Diagnosis of endolymphatic hydrops in vivo with magnetic resonance imaging.
abstract: OBJECTIVE
  High-resolution magnetic resonance imaging (MRI) at 1.5 T preferentially enhances the perilymph over endolymph after administration of contrast with gadodiamide, which allows for differentiation of the membranous labyrinth. Furthermore, this imaging allows for the detection of endolymphatic hydrops.
  
  
  BACKGROUND
  Endolymphatic hydrops is believed to be associated with a number of ear diseases, including Ménière's disease. Although the pathologic changes of overaccumulation of endolymph in the inner ear are obvious on postmortem histologic examination of the temporal bone, they have yet to be observed in a living organism. Previous attempts to visualize this condition with high-resolution contrast-enhanced computed tomographic imaging and MRI have been unsuccessful.
  
  
  METHODS
  Healthy pigmented guinea pigs underwent a unilateral surgical ablation of the endolymphatic sac to create endolymphatic hydrops in the ear. High-resolution temporal bone imaging was performed by use of a 1.5-T MRI system. Two-dimensional images were acquired by a spin-echo technique with and without contrast enhancement by gadodiamide.
  
  
  RESULTS
  T1-weighted gadodiamide contrast-enhanced MRI of the midmodiolar level of the cochlea demonstrated that the perilymph appeared to be preferentially enhanced relative to the endolymph, resulting in a clear distinction between the scalae of the inner ear. The contrast-enhanced T1-weighted MRI of the midmodiolar level of the hydropic cochlea demonstrated a significantly enlarged scala media in comparison with the normal cochlea in the same animal.
  
  
  CONCLUSIONS
  The demonstration of endolymphatic hydrops has been possible for the first time in vivo by the use of a standard 1.5-T MRI system. This research has important clinical implications: Specifically, this technique may allow for the noninvasive diagnosis of Ménière's disease.
authors.affiliation: Department of Radiological Sciences, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095-1624, U.S.A.
authors.forename: D M
authors.initials: DM
authors.lastname: Niyazov
authors.forename: J C
authors.initials: JC
authors.lastname: Andrews
authors.forename: D
authors.initials: D
authors.lastname: Strelioff
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: R
authors.initials: R
authors.lastname: Lufkin
mesh_terms: D000818:Animals; D003051:Cochlea / Q000473:pathology*; D003287:Contrast Media; D004710:Endolymph / Q000502:physiology; D018159:Endolymphatic Hydrops / Q000175:diagnosis*; D019786:Gadolinium DTPA; D006168:Guinea Pigs; D008279:Magnetic Resonance Imaging; D008575:Meniere Disease / Q000175:diagnosis*; D010498:Perilymph / Q000502:physiology; D013701:Temporal Bone / Q000473:pathology*
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA