title: [Implantation of flakes of castor oil resin in rat dental alveolus].
abstract: The purposes of the present study were: 1) to investigate the biocompatibility of a natural resin (made of fatty acids extracted from Ricinus communis) implanted in the dental alveolus of rats and 2) to verify any possible interference of that material in the osseous healing following tooth extraction. The resin (AUG-EX, Poliquil Araraquara Polímeros Químicos LTDA, Araraquara--SP) was placed inside de alveoli immediately after extraction of the upper right incisors. The animals were sacrificed 1, 2, 3 and 6 weeks after extraction or extraction + implantation. The hemi-maxillae were decalcified and processed for paraffin embedding. Longitudinal 6-micrometer-thick semi-serial sections stained with hematoxylin and eosin were obtained. Histologic examination showed particles of irregular shape and variable size (700-1200 microns) localized in the medium/cervical alveolar thirds, with a scanty but persistent foreign body reaction. From the second week on, as the relative volume of bone trabeculae increased, it was seen in close contact with the surface of the implanted material in some regions. Histometric analysis (differential point counting method), used to quantify the healing process in the apical third, showed a small but significant decrease (13%-20%) in new bone formation in the implanted rats. In conclusion, the results show that, in spite of its biocompatible nature, the studied resin hinders the post-extration healing process.
authors.affiliation: Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirão Preto da USP.
authors.forename: R F
authors.initials: RF
authors.lastname: Calixto
authors.forename: J M
authors.initials: JM
authors.lastname: Teófilo
authors.forename: L G
authors.initials: LG
authors.lastname: Brentegani
authors.forename: T L
authors.initials: TL
authors.lastname: Carvalho
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012276:Ricin; D020390:Tooth Socket / Q000473:pathology
chemical_list: D001672:Biocompatible Materials; D012276:Ricin