title: Cobalt-55 positron emission tomography in vascular dementia: significance of white matter changes.
abstract: BACKGROUND
  Vascular dementia (VaD) is still used as a covering term to indicate the relationship between cerebrovascular disease and the progressive cognitive disorder. The contribution of white matter changes (WMCs), seen with computed tomography (CT) and magnetic resonance imaging (MRI) of the brain, to dementia had not been fully elucidated. Cobalt-55 (55Co) positron emission tomography (PET) allows us to distinguish between recent and old infarcts.
  
  
  OBJECTIVE
  The present study investigates whether 55Co PET can detect the lesions responsible for the progression of the cognitive disorder in VaD patients.
  
  
  METHODS
  20 consecutive patients with a previous history of repeated strokes occurring more than 6 months before and with multiple cortical infarcts, lacunes and WMCs on CT and 5 age-matched controls were investigated with 55Co PET. The stroke patients were divided in two groups: 8 with and 12 without VaD. Average 55Co counts in cerebral cortex, deep gray nuclei and white matter were compared to the value in the cerebellum used as reference.
  
  
  RESULTS
  In the control group, the 55Co uptake was identical in the cerebral cortex and in the cerebellum, but lower in the deep gray nuclei and the cerebral white matter. When comparing the stroke groups with the control, the 55Co uptake was similar for the cerebral cortex and deep gray nuclei, but significantly increased in the cerebral white matter. The 55Co uptake was also more increased in the stroke group with VaD compared to the non-demented group.
  
  
  CONCLUSIONS
  55Co PET shows that the WMCs are due to the ongoing damage of probably ischaemic origin which is more prominent in stroke patients with progressive cognitive decline.
authors.affiliation: Department of Neurology, Ghent University Hospital, De Pintelaan 185, B-9000, Ghent, Belgium. jacques.dereuck@yucom.be
authors.forename: J
authors.initials: J
authors.lastname: De Reuck
authors.forename: P
authors.initials: P
authors.lastname: Santens
authors.forename: K
authors.initials: K
authors.lastname: Strijckmans
authors.forename: I
authors.initials: I
authors.lastname: Lemahieu
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D020520:Brain Infarction / Q000000981:diagnostic imaging* / Q000473:pathology; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003037:Cobalt Radioisotopes; D015140:Dementia, Vascular / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000000981:diagnostic imaging* / Q000473:pathology; D012307:Risk Factors; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D003037:Cobalt Radioisotopes