Effects of olopatadine hydrochloride on the cutaneous vascular hyperpermeability and the scratching behavior induced by poly-L-arginine in rats.
Intradermal injections of poly-L-arginine induce cutaneous vascular hyperpermeability and scratching behavior in rats. Recently, we elucidated that the plasma extravasation involved both histamine and substance P, while the scratching behavior involved substance P, but not histamine. This study examined the effects of olopatadine hydrochloride (olopatadine), an antiallergic drug with histamine H1-antagonistic action, on the poly-L-arginine-induced responses. Olopatadine (1 mg/kg, p.o.) significantly inhibited both the plasma extravasation and the scratching behavior, suggesting that its inhibitory effects are mediated by the suppression of neuropeptidergic action as well as histaminic action. Olopatadine seems to be a novel-type drug for the treatment of dermatitis.
Hayashi
K
K
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd, Sunto-gun, Shizuoka, Japan.
Kaise
T
T
Ohmori
K
K
Ishii
A
A
Karasawa
A
A
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects*; D003990:Dibenzoxepins / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D008833:Microcirculation; D000069605:Olopatadine Hydrochloride; D010455:Peptides; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000098:blood supply*; D015320:Tachykinins / Q000037:antagonists & inhibitors / Q000378:metabolism
D018926:Anti-Allergic Agents; D003990:Dibenzoxepins; D006634:Histamine H1 Antagonists; D010455:Peptides; D015320:Tachykinins; C015462:polyarginine; D000069605:Olopatadine Hydrochloride