G-protein beta3 subunit C825T polymorphism: no association with risk for hypertension and obesity.
OBJECTIVE
Several recent studies have indicated that a C825T polymorphism in the gene encoding the G-protein beta3 subunit is a significant risk factor for hypertension and obesity. In this study, we tested whether this polymorphism is associated with hypertension and obesity in white men.


METHODS
Population-based prospective cohort study.


METHODS
We followed a cohort of 903 men, aged 42-61 years at baseline, for an average time of 4.2 years. Genotyping was performed by polymerase chain reaction.


RESULTS
The genotype distribution was in Hardy-Weinberg equilibrium: 514 (57%) had the CC genotype, 49 (5%) had the TT genotype and 340 (38%) were heterozygous (T:C = 0.24:0.76). There was no statistically significant difference between the genotype groups in respect to baseline and end of follow-up risk for hypertension or obesity, systolic or diastolic blood pressure, or body mass index.


CONCLUSIONS
We conclude that the C825T polymorphism of the G-protein beta3 subunit gene does not notably contribute to the development of hypertension or obesity, and is not a significant determinant for blood pressure and body mass index in white men.
Snapir
A
A
Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland.
Heinonen
P
P
Tuomainen
T P
TP
Lakka
T A
TA
Kauhanen
J
J
Salonen
J T
JT
Scheinin
M
M
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D015992:Body Mass Index; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D020033:Protein Isoforms / Q000235:genetics
D000959:Antihypertensive Agents; D020033:Protein Isoforms; D020962:Heterotrimeric GTP-Binding Proteins