Rapid growth of giant cell granuloma in pregnancy treated with calcitonin.
The giant cell granuloma of the jaws is a benign osteolytic lesion that may be treated by curettage, intralesional corticosteroids, or calcitonin. These medical treatments may be particularly useful when lesions arise in the immature facial skeleton, recur, or enlarge very rapidly-the last two situations being recognized complications of pregnancy. In this study, a patient is presented with a central giant cell lesion of the maxilla that switched from a relatively indolent growth pattern to become a rapidly enlarging and destructive lesion in the maxilla almost immediately after the patient became pregnant. Although calcitonin treatment is normally avoided in pregnancy, it proved highly effective, caused no obstetric or fetal side effects, and was not contraindicated by renal failure due to lupus nephritis. Histologically, the lesion was converted to a fibro-osseous lesion-like appearance. On the basis of the results of this case, calcitonin appears to be a safe, effective, and conservative treatment for giant cell granulomas that enlarge rapidly during pregnancy.
O'Regan
E M
EM
Central Pathology Laboratory, St James's Hospital, Dublin, Ireland, United Kingdom.
Gibb
D H
DH
Odell
E W
EW
D000328:Adult; D001706:Biopsy; D001857:Bone Matrix / Q000473:pathology; D002116:Calcitonin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005355:Fibrosis; D015726:Giant Cells / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous; D008439:Maxillary Diseases / Q000188:drug therapy* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000473:pathology
D002116:Calcitonin