[Thalidomide--a dreaded drug with new indications].
BACKGROUND
Thalidomide was introduced as a non-toxic sleeping pill in 1957 and was prescribed in more than 20 countries. In 1961 the link between congenital limb defects and thalidomide use in pregnancy was proven, resulting in withdrawal of the drug.


METHODS
On the basis of literature searches and personal experience we review the effects and use of thalidomide today.


RESULTS
In vitro, thalidomide has immunoregulatory properties. This has lead to the administration of thalidomide in many immunological diseases. In 1964 it was discovered that thalidomide was effective against erythema nodosum leprosum. Thalidomide also has effect on aphthous stomatitis and Behçet's disease. The effect is more uncertain in graft-versus-host-disease, rheumatoid arthritis and Crohn's disease. Thalidomide reduces angiogenesis in experimental animals, and this has led to several studies of thalidomide as a possible anticancer drug. Advanced or resistant multiple myeloma may be a new target for thalidomide; at least 30% of these patients obtain response during treatment. Results indicate that patients with breast cancer and glioma do not benefit from treatment with thalidomide.


CONCLUSIONS
Thalidomide has proven to be effective in the treatment of erythema nodosum leprosum and aphthous stomatitis. It is also effective in advanced multiple myeloma, but not in other cancers.
Waage
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A
Hematologisk seksjon Medisinsk avdeling Regionsykehuset i Trondheim 7006 Trondheim. anders.waage@medisin.ntnu.no
Seidel
C
C
D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000266:history; D019380:Anti-HIV Agents / Q000008:administration & dosage; D000075202:Contraindications; D003879:Dermatologic Agents / Q000008:administration & dosage; D005260:Female; D049673:History, 20th Century; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000266:history; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007917:Leprostatic Agents / Q000008:administration & dosage; D008297:Male; D011247:Pregnancy; D013723:Teratogens / Q000266:history; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects / Q000266:history
D019380:Anti-HIV Agents; D003879:Dermatologic Agents; D006993:Hypnotics and Sedatives; D007166:Immunosuppressive Agents; D007917:Leprostatic Agents; D013723:Teratogens; D013792:Thalidomide