title: Capsaicin in albino rats prevents contralateral testis from the damaging effects posed by ipsilateral testis that underwent torsion.
abstract: OBJECTIVE
  To evaluate the effect of capsaicin, a powerful neurotoxin selective to afferent nerves, on contralateral testicular damage in ipsilateral testicular torsion.
  
  
  METHODS
  Forty male albino rats were randomly allocated into five groups. No operation was performed in group one. After intraperitoneal administration of 0.9% NaCl, rats underwent a sham operation in group 2 and testicular torsion in group 3. In groups 4 and 5 rats underwent sham operation and testicular torsion, respectively after intraoperitoneal capsaicin injection. Contralateral testes were harvested on the fifteenth day of the experiment and mean seminiferous tubular diameters and mean testicular biopsy scores were recorded for each testis. The values were compared through analysis of variance (ANOVA) with Turkey-Kramer multiple comparisons test and p values less than 0.05 were considered to be significant.
  
  
  RESULTS
  Mean testicular biopsy scores and mean seminiferous tubular diameters of group 5 was significantly higher than the group 3. There was no difference between the groups 1, 2, 4, and 5 when these two parameters are concerned.
  
  
  CONCLUSIONS
  Capsaicin effectively prevents contralateral testicular damage encountered following ipsilateral testicular torsion. The inhibition of afferent impulses from the ipsilateral testis under distress prevents contralateral testicular injury, and provides additional data to support the role of an autonomic reflex arc in contralateral testicular injury.
authors.affiliation: Department of Pediatric Surgery, Pamukkale University Faculty of Medicine, Denizli, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Sarioglu
authors.forename: G
authors.initials: G
authors.lastname: Gedikoglu
authors.forename: M
authors.initials: M
authors.lastname: Bingol-Kologlu
authors.forename: N
authors.initials: N
authors.lastname: Büyükpamukçu
authors.forename: F C
authors.initials: FC
authors.lastname: Tanyel
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002211:Capsaicin / Q000627:therapeutic use*; D008297:Male; D009498:Neurotoxins / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D013086:Spermatic Cord Torsion / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D013373:Substance P / Q000378:metabolism; D013737:Testis / Q000294:innervation / Q000473:pathology*
chemical_list: D009498:Neurotoxins; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin