title: Prevention of anterior glottic restenosis in a canine model with topical mitomycin-C.
abstract: To develop a model for recurrent anterior glottic stenosis and to test the efficacy of topical mitomycin-C in preventing restenosis, we induced anterior glottic stenosis with a CO2 laser in 5 dogs. In 3 dogs, recurrence was established after surgical lysis. Subsequently, the 3 dogs received a single topical 3-minute treatment with a 1% solution of mitomycin-C after a second surgical lysis. In a parallel experiment, the other 2 dogs received a single topical 3-minute treatment with a 1% solution of mitomycin-C after the initial surgical lysis. An anterior glottic web was induced in all 5 dogs with the CO2 laser. The 3 dogs experienced restenosis at the anterior glottis after surgical lysis alone. Mitomycin-C prevented anterior glottic restenosis in 2 of the 3 dogs treated twice and in both of the dogs treated once (p = .02). We conclude that a recurrent stenosis of the anterior glottis may be induced reproducibly in the canine model with the CO2 laser. Application of topical mitomycin-C after lysis of an anterior glottic stenosis produces a statistically significant reduction in the rate of restenosis as compared to surgical lysis alone.
authors.affiliation: Department of Otolaryngology, Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2559, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Spector
authors.forename: J A
authors.initials: JA
authors.lastname: Werkhaven
authors.forename: N C
authors.initials: NC
authors.lastname: Spector
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: D
authors.initials: D
authors.lastname: Sanders
authors.forename: L
authors.initials: L
authors.lastname: Reinisch
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D005931:Glottis; D007829:Laryngostenosis / Q000517:prevention & control* / Q000601:surgery; D016685:Mitomycin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D012008:Recurrence
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin