[Better treatment of heart failure by measurements of natriuretic peptides. There are still remaining problems when it comes to the interpretation of measurement levels].
The heart is increasingly being recognised as a major endocrine organ involved in haemodynamic homeostasis. Natriuretic peptides, i.e. atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), affect renal, adrenal and central nervous system functions as well as vessel tonus and permeability thus causing decreased preload and afterload. Natriuretic peptides, BNP in particular, are independent risk factors for morbidity and mortality. They also have high negative predictive values for cardiac insufficiency indicating high diagnostic sensitivity for heart failure in outpatient practice. Monitoring of therapy for heart failure may be improved if BNP measurement is used in conjunction with clinical assessment. However, several problems remain to be solved, such as optimal decision limits in relation to sex and age for the assessment of heart failure.
Lindstedt
G
G
Avdelningen för klinisk kemi och transfusionsmedicin, Sahlgrenska akademin vid Göteborgs universitet. goran.lindstedt.gu@telia.com
Dahlström
U
U
Fernlund
P
P
Schaufelberger
M
M
Stridsberg
M
M
D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D016903:Drug Monitoring / Q000379:methods*; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor