Sterically stabilized liposomes in cancer therapy and gene delivery.
The introduction of colloidally stable liposomes with low drug leakage rates resulted in a renaissance in liposome applications in cancer therapy. Furthermore, a platform of sterically stabilized liposomes also allows the construction of new generations of drug delivery vehicles. These include targeted liposomes and targeted nucleic acid delivery vehicles, based either on cationic sterically stabilized liposomes or pre-condensed DNA encapsulated in neutral or negatively charged liposomes.
Lasic
D D
DD
Liposome Consultations, Newark, CA 94560, USA. Dan.Lasic@roche.com
Vallner
J J
JJ
Working
P K
PK
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D002945:Cisplatin / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D004317:Doxorubicin / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D015316:Genetic Therapy; D006801:Humans; D008081:Liposomes; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*
D000970:Antineoplastic Agents; D008081:Liposomes; D004317:Doxorubicin; D002945:Cisplatin