Glioma migration: clues from the biology of neural progenitor cells and embryonic CNS cell migration.
Neural stem cells have recently come to the forefront in neurobiology because of the possibilities for CNS repair by transplantation. Further understanding of the biology of these cells is critical for making their use in CNS repair possible. It is likely that these discoveries will also have spin-offs for neuro-oncology as primary brain tumors may arise from a CNS progenitor cell. An understanding of the normal migratory ability of these cells is also likely to have a very important impact on the knowledge of brain tumor invasion.
Dirks
P B
PB
Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Ontario, Canada. peter.dirks@sickkids.on.ca
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D016380:Brain Tissue Transplantation; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D002465:Cell Movement / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology*; D029721:Drosophila Proteins; D005314:Embryonic and Fetal Development; D005326:Fetal Proteins / Q000502:physiology; D016332:Fetal Tissue Transplantation; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006023:Glycoproteins / Q000502:physiology; D006801:Humans; D007797:Laminin / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D009024:Morphogenesis; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009363:Neoplasm Proteins / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D011323:Primates; D051381:Rats; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*
C072976:Astn1 protein, mouse; D029721:Drosophila Proteins; D005326:Fetal Proteins; D006023:Glycoproteins; D007797:Laminin; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; C066819:sli protein, Drosophila