Fluorinated analogues of tert-butyl alcohol as novel protecting groups for use in fluorous synthesis.
[reaction--see text] A series of fluorous derivatives of tert-butyl alcohol were prepared and evaluated as reagents for the protection of carboxylic acids for use in fluorous synthesis. Alcohol 3b can be employed efficiently to protect and immobilize medium-size nonpolar carboxylic acids in a fluorous phase.
Pardo
J
J
Departamento de Química Orgánica, Facultade de Ciencias, Universidade de Santiago de Compostela, Campus Universitario, 27002 Lugo, Spain.
Cobas
A
A
Guitián
E
E
Castedo
L
L