title: Distribution of CCR5-Delta 32 and CCR2-64I alleles in an Argentine Amerindian population.
abstract: In order to evaluate the frequency distributions of CCR5-Delta 32 and CCR2-64I polymorphisms in an Amerindian population, we tested a total of 42 Chiriguanos individuals that are aboriginal inhabitants of the north west of Argentina. Only one carried the CCR5-Delta 32 allele (0.0238), while 17 out of 35 carried the CCR2-64I mutation, including one homozygous for the mutated allele (0.2571). Although the cohort studied is considered highly endogamic, the HLA genotyping revealed that 8 out of 42 subjects had a gene flow from Caucasian populations. The only heterozygous CCR5+/Delta 32 found and three heterozygous CCR2+/64I belonged to the admix group. In conclusion, the protective deletion CCR5-Delta 32 is practically absent in Chiriguanos whereas the CCR2-64I allele is highly frequent.
authors.affiliation: Laboratorio de Biología Celular y Retrovirus, Hospital de Pediatría JP Garrahan, Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Mangano
authors.forename: G
authors.initials: G
authors.lastname: Theiler
authors.forename: L
authors.initials: L
authors.lastname: Sala
authors.forename: M
authors.initials: M
authors.lastname: Capucchio
authors.forename: L
authors.initials: L
authors.lastname: Fainboim
authors.forename: L
authors.initials: L
authors.lastname: Sen
mesh_terms: D000483:Alleles; D001118:Argentina; D005838:Genotype; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D011110:Polymorphism, Genetic; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000235:genetics*; D019707:Receptors, Chemokine / Q000235:genetics
chemical_list: C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine