title: Recurrent pyogenic vertebral osteomyelitis associated with type 2 diabetes mellitus.
abstract: We report a case of recurrent pyogenic vertebral osteomyelitis associated with type 2 diabetes mellitus. A 51-year-old male was admitted to our hospital because of lumbago and general fatigue, with multiple ulcers on the soles of his feet. Staphylococcus aureus was isolated from peripheral blood and the foot ulcers, and 67Gallium scintigram showed abnormal isotope uptake, accumulated at the lower thoracic spine. Antibiotics were administered and the patient underwent intensive insulin therapy. Magnetic resonance imaging (MRI), performed after the levels of C-reactive protein decreased to 0.0 mg/dl, indicated old inflammatory changes at the Th8-Th9 spine and antibiotics were stopped. Unexpectedly, 8 days later the patient complained of lumbago with fever again, and MRI showed acute inflammatory changes at the same lesion site. This case report suggests that it is important for complementary antibiotic therapy to continue after signs of inflammation have disappeared in cases of pyogenic vertebral osteomyelitis.
authors.affiliation: Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: Z
authors.initials: Z
authors.lastname: Isobe
authors.forename: T
authors.initials: T
authors.lastname: Utsugi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohyama
authors.forename: A
authors.initials: A
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Okuno
authors.forename: T
authors.initials: T
authors.lastname: Uchiyama
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: M
authors.initials: M
authors.lastname: Arai
authors.forename: S
authors.initials: S
authors.lastname: Tomono
authors.forename: M
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D017719:Diabetic Foot / Q000175:diagnosis / Q000382:microbiology; D004452:Echocardiography; D005221:Fatigue / Q000209:etiology; D006801:Humans; D017116:Low Back Pain / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000175:diagnosis* / Q000209:etiology; D012008:Recurrence; D013122:Spinal Diseases / Q000175:diagnosis* / Q000209:etiology; D013203:Staphylococcal Infections / Q000175:diagnosis; D016896:Treatment Outcome