Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease.
Dingwall
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Neurology-CEDD, New Frontiers Science Park, Third Avenue, Harlow CM19 5AW, United Kingdom.Colin_Dingwall@sbphrd.com
D000375:Aging; D000544:Alzheimer Disease / Q000201:enzymology* / Q000473:pathology / Q000628:therapy; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000502:physiology; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism* / Q000502:physiology*; D018076:DNA, Complementary / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
D016229:Amyloid beta-Peptides; D018076:DNA, Complementary; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509284:BACE2 protein, human; C509280:BACE1 protein, human