Carbohydrate mimetics-based glycosyltransferase inhibitors.
The search for carbohydrate mimetics-based glycosyltransferase inhibitors is a dynamic field that emerged 10 years ago. This review presents a description of the different types of glycosyltransferase inhibitors containing a carbohydrate mimetic (primarily an iminosugar, a carbasugar or a C-glycoside) and data on their biological activity whenever such data are available. The purpose of this account is to foster a synergy between the two expanding research areas of glycomimetics and glycosyltransferases.
Compain
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Institut de Chimie Organique et Analytique, CNRS UMR 6005, Université d'Orléans, BP 6759, 45067 Orléans, France. philippe.compain@univ-orleans.fr
Martin
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D000818:Animals; D002241:Carbohydrates / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D006801:Humans; D018716:Molecular Mimicry
D002241:Carbohydrates; D004791:Enzyme Inhibitors; D006027:Glycosides; D016695:Glycosyltransferases