Regulation of colony stimulating factor-1 (CSF-1) in endometrial cells: glucocorticoids and oxidative stress regulate the expression of CSF-1 and its receptor c-fms in endometrial cells.
OBJECTIVE
To evaluate the regulation and expression of CSF-1 and its receptor c-fms in endometrial cells.


METHODS
In vitro study.


METHODS
Research and teaching institution.


METHODS
None.


METHODS
In vitro experimental study.


METHODS
The effect of glucocorticoid and oxidative stress on the expression of CSF-1 and c-fms in endometrial cells.


RESULTS
Cultured nonmalignant EM42 cells not only express CSF-1 and c-fms but are also capable of responding to exogenous CSF-1. We have also seen that glucocorticoids can regulate the expression of CSF-1/c-fms in endometrial cells. Furthermore, this study shows that oxidative stress plays a significant role in the induction of CSF-1 and its receptor c-fms.


CONCLUSIONS
The results suggest that CSF-1 may promote the growth of nonmalignant endometrial cells in both an autocrine and paracrine manner and that endometrial cells under oxidative stress induce CSF-1 and c-fms.
Gill
K
K
Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Kirma
N
N
Gunna
V S
VS
Santanam
N
N
Parthasarathy
S
S
Tekmal
R R
RR
D002460:Cell Line; D003907:Dexamethasone / Q000494:pharmacology*; D004717:Endometrium / Q000166:cytology / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000187:drug effects / Q000378:metabolism* / Q000494:pharmacology; D018384:Oxidative Stress / Q000502:physiology*; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000378:metabolism*
D005938:Glucocorticoids; D003907:Dexamethasone; D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor