Extrapyramidal effects of SSRI antidepressants.
(1) About a hundred detailed reports of extrapyramidal adverse effects linked to a "selective" serotonin reuptake inhibitor (SSRI) antidepressant have been published. (2) The effects include acute dystonia, akathisia, and onset or aggravation of parkinsonism. Late-onset dyskinesias are rare. (3) All SSRIs have been implicated. (4) The annual incidence is unclear. It has been estimated at about 1-2 cases per 1 000 patients. (5) In patients with Parkinson's disease, SSRIs are an alternative to tricyclic antidepressants but can worsen the disease itself.
D020820:Dyskinesias / Q000209:etiology; D005116:Extrapyramidal Tracts / Q000187:drug effects*; D006801:Humans; D010300:Parkinson Disease; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D017367:Selective Serotonin Reuptake Inhibitors