title: The impact of biology on the treatment of secondary AML.
authors.affiliation: University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, USA.
authors.forename: I
authors.initials: I
authors.lastname: Gojo
authors.forename: J E
authors.initials: JE
authors.lastname: Karp
mesh_terms: D000208:Acute Disease; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000627:therapeutic use; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics / Q000648:ultrastructure; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics / Q000648:ultrastructure; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000235:genetics; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D005544:Forecasting; D016147:Genes, Tumor Suppressor; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D056572:Histone Deacetylase Inhibitors; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007942:Leukemia, Experimental / Q000209:etiology / Q000473:pathology; D007951:Leukemia, Myeloid / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics; D007953:Leukemia, Radiation-Induced / Q000473:pathology; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D051788:Myeloid-Lymphoid Leukemia Protein; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D016609:Neoplasms, Second Primary / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000187:drug effects; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000473:pathology; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011519:Proto-Oncogenes; D017154:Stromal Cells / Q000473:pathology; D059005:Topoisomerase II Inhibitors; D014157:Transcription Factors; D014178:Translocation, Genetic; D023041:Xenograft Model Antitumor Assays
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; C497422:KMT2A protein, human; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; D059005:Topoisomerase II Inhibitors; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; C497423:Kmt2a protein, mouse