title: Treatment of idiopathic restless legs syndrome (RLS) with gabapentin.
abstract: Nine patients with idiopathic restless legs syndrome (RLS) were treated with 300 mg of gabapentin as an initial dose and an up-titration until relief of symptoms for 4 weeks. Subjective symptoms improved significantly. Polysomnographic data showed a reduction of periodic leg movements during sleep (PLMS) (p = 0.003) and PLMS index (p = 0.001). The authors conclude that gabapentin provides a well-tolerated and effective treatment of idiopathic RLS.
authors.affiliation: Department of Clinical Neurology, University of Vienna, Austria. happes@uni-muenster.de
authors.forename: S
authors.initials: S
authors.lastname: Happe
authors.forename: G
authors.initials: G
authors.lastname: Klösch
authors.forename: B
authors.initials: B
authors.lastname: Saletu
authors.forename: J
authors.initials: J
authors.lastname: Zeitlhofer
mesh_terms: D000085:Acetates / Q000008:administration & dosage* / Q000009:adverse effects; D000368:Aged; D000588:Amines; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D003509:Cyclohexanecarboxylic Acids; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin