Therapeutic efficacy of hamycin, a polyene antimycotic agent, for experimental cutaneous candidiasis in guinea pigs.
The therapeutic efficacy of 1% cream and 1% solution of hamycin, a polyene antimycotic agent, in the model of cutaneous candidiasis in prednisolone-treated guinea pigs was evaluated in comparison with that of comparable formulations of miconazole. Each preparation was topically applied once a day for three consecutive days starting on the fifth day post infection, and quantitative culture study was conducted on the ninth day post infection. Both formulations were much more highly effective in terms of eradication of fungi like miconazole formulations.
Dhuley
J N
JN
Pharmacology and Toxicology Section, Research and Development Division, Hindustan Antibiotics Ltd., Pimpri, Pune 411 018, India.
D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002176:Candida albicans / Q000187:drug effects; D002179:Candidiasis, Cutaneous / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D008825:Miconazole / Q000008:administration & dosage; D008826:Microbial Sensitivity Tests; D011090:Polyenes / Q000008:administration & dosage*
D000935:Antifungal Agents; D011090:Polyenes; C100114:hamycin; D008825:Miconazole