title: Cyclo-oxygenase 2 inhibitors: an important new drug classification.
abstract: The pharmacologic treatment of acute and chronic pain has evolved greatly over the last several decades. Notably, several new classifications of drugs have emerged to meet the growing demand of patients in pain and health care providers who attempt to assist them. This article describes 1 new classification, cyclo-oxygenase 2 inhibitors, and provides specifics about the 2 agents currently available via prescription.
authors.affiliation: Department of Nursing, University of Tampa, Osteoporosis Testing Center, Tampa, FL, USA. ckessenich@alpha.utampa.edu
authors.forename: C R
authors.initials: CR
authors.lastname: Kessenich
mesh_terms: D000208:Acute Disease; D000700:Analgesics / Q000145:classification* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000145:classification* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D016718:Arachidonic Acid / Q000378:metabolism; D000068579:Celecoxib; D002908:Chronic Disease; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000145:classification* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D005544:Forecasting; D006801:Humans; D007249:Inflammation; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D007783:Lactones / Q000145:classification* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D008565:Membrane Proteins; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D018579:Patient Selection; D011451:Prostaglandin-Endoperoxide Synthases; D011720:Pyrazoles; D013449:Sulfonamides / Q000145:classification* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D013450:Sulfones
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D007783:Lactones; D008565:Membrane Proteins; D011720:Pyrazoles; D013449:Sulfonamides; D013450:Sulfones; C116926:rofecoxib; D016718:Arachidonic Acid; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D000068579:Celecoxib