Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.
There is accumulating evidence that T-cell-mediated dominant control of self-reactive T-cells contributes to the maintenance of immunologic self-tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T-cell population have revealed that CD25+ cells in the CD4+ population in normal naive animals bear the ability to prevent autoimmune disease in vivo and, upon antigenic stimulation, suppress the activation/proliferation of other T cells in vitro. The CD25+ CD4+ regulatory T cells, which are naturally anergic and suppressive, appear to be produced by the normal thymus as a functionally distinct subpopulation of T cells. They play critical roles not only in preventing autoimmunity but also in controlling tumor immunity and transplantation tolerance.
Sakaguchi
S
S
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. shimon@frontier.kyoto-u.ac.jp
Sakaguchi
N
N
Shimizu
J
J
Yamazaki
S
S
Sakihama
T
T
Itoh
M
M
Kuniyasu
Y
Y
Nomura
T
T
Toda
M
M
Takahashi
T
T
D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D017635:Clonal Anergy / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000276:immunology* / Q000378:metabolism; D017634:Self Tolerance / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology; D023001:Transplantation Tolerance / Q000276:immunology*
D015375:Receptors, Interleukin-2