title: A bioactive spirolactone iridoid and triterpenoids from Himatanthus sucuuba.
abstract: Himatanthus sucuuba is an Amazonian tree with abundant, yet conflicting ethnobotanical information. Investigation of the polar and non-polar constituents led to the isolation of plumericin, a bioactive spirolactone iridoid, and four known pentacylic triterpenes: lupeol acetate, lupeol cinnamate, lupeol beta-phenyl propionate, and alpha-amyrin cinnamate.
authors.affiliation: Department of Chemistry and Biochemistry, University of Massachusetts-Dartmouth, 02747, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Wood
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.forename: A J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: D G
authors.initials: DG
authors.lastname: Kingston
authors.forename: C C
authors.initials: CC
authors.lastname: Neto
authors.forename: G B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D019073:HT29 Cells; D006801:Humans; D007192:Indenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D039823:Iridoids; D051379:Mice; D008807:Mice, Inbred BALB C; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D013148:Spironolactone / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D007192:Indenes; D039823:Iridoids; D010936:Plant Extracts; D014315:Triterpenes; D013148:Spironolactone; C068511:plumericin