title: 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder.
abstract: Genetic factors, such as the genes involved in the serotonin pathway, probably play an important role in the pathogenesis of bipolar disorder, and serotonin type 2A (5-HT2A) receptor gene promoter polymorphism -1438A/G has been reported. This study investigated the association between -1438A/G polymorphism of 5-HT2A receptor gene promoter and bipolar disorder in a Korean population. Using the polymerase chain reaction, -1438A/G polymorphism typed in 142 patients with bipolar disorder and in 148 normal control subjects. Differences in genotype distributions and allele frequencies of -1438A/G between patients with bipolar disorder and normal control subjects were tested for significance using the chi-squared test. There were significant differences in genotype distributions [chi2 = 9.697, degrees of freedom (df) = 2, P = 0.008] and allele frequencies (chi2 = 7.284, df = 1, P = 0.007) of -1438A/G between patients with bipolar disorder and normal control subjects. Although further studies are necessary, these results in a Korean population suggest that -1438A/G polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder.
authors.affiliation: Department of Psychiatry, Chungnam National University Hospital, College of Medicine, Chungnam National University, Jung-Ku, Taejon, Korea. ischee@cnu.ac.kr
authors.forename: I S
authors.initials: IS
authors.lastname: Chee
authors.forename: S W
authors.initials: SW
authors.lastname: Lee
authors.forename: J L
authors.initials: JL
authors.lastname: Kim
authors.forename: S K
authors.initials: SK
authors.lastname: Wang
authors.forename: Y O
authors.initials: YO
authors.lastname: Shin
authors.forename: S C
authors.initials: SC
authors.lastname: Shin
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: H M
authors.initials: HM
authors.lastname: Hwang
authors.forename: M R
authors.initials: MR
authors.lastname: Lim
mesh_terms: D000225:Adenine; D000328:Adult; D044466:Asian People; D001714:Bipolar Disorder / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006147:Guanine; D006801:Humans; D007723:Korea; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D012016:Reference Values
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D006147:Guanine; D000225:Adenine