title: Infundibulohypophysitis in a man presenting with diabetes insipidus and cavernous sinus involvement.
abstract: Infundibulohypophysitis is an unusual inflammatory condition that affects the infundibulum, the pituitary stalk, and the neurohypophysis and may be part of a range that includes lymphocytic hypophysitis. Lymphocytic hypophysitis occurs mainly in women and most often presents in the later stages of pregnancy. Infundibulohypophysitis usually presents with diabetes insipidus and the cause remains unclear. The case of a 46 year old man with a 12 week history of polyuria and polydipsia is reported. Cranial diabetes insipidus was diagnosed on the basis of a water deprivation test. Initial cranial and pituitary imaging studies were normal. He subsequently developed symptoms of panhypopituitism over a period of 6-9 months and then, more acutely, developed diplopia secondary to a fourth nerve palsy. Further brain imaging studies disclosed an enhancing pituitary stalk and a left cavernous sinus lesion. An initial trial of immunosuppressive treatment did not help symptoms significantly. The diagnosis of infundibulohypophysitis was made on histological evidence. The patient was treated with prednisolone and methotrexate. At 9 months he is well, without symptoms, and the radiological abnormalities have resolved.
authors.affiliation: National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. nutubridy@hotmail.com
authors.forename: N
authors.initials: N
authors.lastname: Tubridy
authors.forename: D
authors.initials: D
authors.lastname: Saunders
authors.forename: M
authors.initials: M
authors.lastname: Thom
authors.forename: S L
authors.initials: SL
authors.lastname: Asa
authors.forename: M
authors.initials: M
authors.lastname: Powell
authors.forename: G T
authors.initials: GT
authors.lastname: Plant
authors.forename: R
authors.initials: R
authors.lastname: Howard
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D002426:Cavernous Sinus; D002908:Chronic Disease; D003919:Diabetes Insipidus / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D004172:Diplopia / Q000209:etiology; D006801:Humans; D007018:Hypopituitarism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007249:Inflammation; D008214:Lymphocytes / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010904:Pituitary Gland, Posterior; D010950:Plasma Cells / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D020432:Trochlear Nerve Diseases / Q000209:etiology
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D011239:Prednisolone; D008727:Methotrexate