[Pathogenetic study of femoral head necrosis caused by cortical steroid].
OBJECTIVE
To study cortical steroid caused femoral head necrosis.


METHODS
We designed an experimental animal model of femoral head necrosis through cortical steroid administration. Lipid analyses of blood samples were made and examined specimens from livers and femoral heads were studied with HE, TEM methods.


RESULTS
Cortical steroid resulted in dearrangement of fat metabolism, lipid change of liver and hyperlipemia.


CONCLUSIONS
The pathogenesis of femoral head necrosis is due to fatty degeneration of osteocytes.
Wen
L
L
Orthopaedic Department of Beijing Hospital, Beijing 100730.
Huang
G
G
Lu
K
K
D000818:Animals; D005260:Female; D005270:Femur Head / Q000648:ultrastructure*; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D010011:Osteocytes / Q000648:ultrastructure; D011241:Prednisone; D011817:Rabbits
D011241:Prednisone