Ammocidin, a new apoptosis inducer in ras-dependent cells from Saccharothrix sp. II. Physico-chemical properties and structure elucidation.
The structure of ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. AJ9571, was elucidated to be as shown in Fig. 1 by NMR and degradation studies. Ammocidin consists of a 20-membered macrolide ring and three deoxy sugars identified as 6-deoxy-L-glucose, D-digitoxose and D-olivomycose.
Murakami
R
R
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
Tomikawa
T
T
Shin-ya
K
K
Shinozaki
J
J
Kajiura
T
T
Seto
H
H
Hayakawa
Y
Y
D000192:Actinomycetales / Q000254:growth & development / Q000378:metabolism*; D017209:Apoptosis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D018631:ras Proteins / Q000378:metabolism
D018942:Macrolides; C440627:ammocidin; D018631:ras Proteins