Role of gene regulation during vestibular compensation: an integrative approach.
Identification of the role of gene regulation in vestibular compensation is one aspect of a larger issue: the identification of molecular bases for plasticity in multiple vestibulo-ocular, vestibulo-spinal, vestibulo-collic, and vestibulo-autonomic responses. To achieve this goal, it is incumbent on investigators to examine molecular events within the contexts of the single neuron, the location of the neuron in pathways, and the timing of the molecular events relative to behavioral compensation. Hence, the goal of identifying molecular bases for a particular compensatory response (e.g., the disappearance of spontaneous nystagmus in the light or the disappearance of static head tilt) requires careful attention to the time course of physiologic compensation and the location of the effects within central pathways that have the potential to affect the responses. The effects of impeding these site-specific and time-specific changes can then be tested to determine their role in the compensatory process. A consideration of the recent literature on molecular events related to the resolution of spontaneous nystagmus in the light indicates that a meaningful approach to these issues requires a broadening of our conceptual approach. Specifically, one must consider the roles of transcriptional, translational, and posttranslational events on the turnover of critical signaling substrates for vestibular compensation.
Balaban
C D
CD
Department of Otolaryngology, University of Pittsburgh, Eye & Ear Institute, Pennsylvania 15213, USA. cbalaban@pitt.edu
D005786:Gene Expression Regulation; D006801:Humans; D009474:Neurons; D014722:Vestibule, Labyrinth / Q000166:cytology / Q000378:metabolism / Q000502:physiology*