title: Behavioral effects of the aqueous extract of Guiera senegalensis in mice and rats.
abstract: Behavioral effects of the aqueous extract of Guiera senegalensis on the central nervous system of mice and rats were investigated. Spontaneous motor activity, pentobarbital sleeping time, amphetamine-stereotyped behavior, exploratory activity and performance on treadmills (rota-rod) were evaluated. The results revealed that the aqueous extract of G. senegalensis reduced spontaneous motor activity in mice, prolonged the duration of pentobarbital sleeping time in rats and attenuated amphetamine-induced stereotype behavior in rats. The extract also decreased exploratory activity in mice and had no observable effects on motor coordination (rota-rod) at the doses tested. The results suggested that the crude aqueous extract of G. senegalensis possesses some biologically active principles that are sedative in nature.
authors.affiliation: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, FCT, Nigeria. samsonamos@yahoo.co.uk
authors.forename: S
authors.initials: S
authors.lastname: Amos
authors.forename: E
authors.initials: E
authors.lastname: Kolawole
authors.forename: P
authors.initials: P
authors.lastname: Akah
authors.forename: C
authors.initials: C
authors.lastname: Wambebe
authors.forename: K
authors.initials: K
authors.lastname: Gamaniel
mesh_terms: D000661:Amphetamine / Q000008:administration & dosage; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D029764:Combretaceae; D005106:Exploratory Behavior / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000008:administration & dosage; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D010936:Plant Extracts; D000661:Amphetamine; D010424:Pentobarbital