Influence of organic and inorganic ions on organolead-induced hemolysis of erythrocytes.
The influence of some inorganic (K+, Mg2+, and Al3+) and organic CnH(2n+1)SO3-, n = 12 and 14) ions was studied on the hemolysis of erythrocytes (RBC) caused by organolead compounds (tripropyllead--TPL, tributyllead--TBL and triphenyllead--TPhL chlorides). It was found that sulfonate anions increased the hemolytic effect induced by triorganoleads, while inorganic cations protected RBC against the triorganoleads action, especially when the latter were used at small concentrations. This protection was weaker when the concentration of organoleads increased and depended on the kind of ion. The protective efficacy sequence was like that: Mg2+ > Al3+ > K+. The less hemolytic of the triorganoleads studied was TPL. TBL was slightly more effective than TPhL. The efficacy of the sulfonate ions to increase the triorganolead chloride-induced hemolysis was practically the same for TPL and TBL. A weaker efficacy of C12H25SO3+ was observed when TPhL was used as RBC membrane modifier.
Kleszczyńska
H
H
Department of Physics and Biophysics, Agricultural University, Wrocław, Poland. Halina@azi.ar.wroc.pl
Sarapuk
J
J
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D007854:Lead / Q000633:toxicity*; D009942:Organometallic Compounds / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013552:Swine
D009942:Organometallic Compounds; C113521:tributyllead chloride; C444650:tripropyllead chloride; C420974:triphenyllead chloride; D007854:Lead