title: Scope and limitations of solid-supported liquid-liquid extraction for the high-throughput purification of compound libraries.
abstract: This paper reports some of the advantages and limitations of solid-supported liquid-liquid extraction (SLE) for the rapid purification of organic compound libraries. Issues of solvent compatibility, compound compatibility, and technical methods are addressed. In addition the prospective use of calculated log P values is investigated to determine which impurities will be effectively removed by this technique. In addition SLE is shown to be complementary and in some cases superior to solid-phase extraction (SPE) methods for library purification. This is especially true when the desired products have functionality equivalent to that of the impurity to be removed.
authors.affiliation: RW Johnson Pharmaceutical Research Institute, 3210 Merryfield Row, San Diego, CA 92121, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Breitenbucher
authors.forename: K L
authors.initials: KL
authors.lastname: Arienti
authors.forename: K J
authors.initials: KJ
authors.lastname: McClure