title: Osteonecrosis in patients with systemic lupus erythematosus develops very early after starting high dose corticosteroid treatment.
abstract: OBJECTIVE
  To investigate the actual time of onset of osteonecrosis (ON) after high dose corticosteroid treatment in systemic lupus erythematosus (SLE).
  
  
  METHODS
  72 patients with active SLE, who received high dose corticosteroid for the first time, for the development of ON at hips and knees were monitored by magnetic resonance imaging for at least 12 months.
  
  
  RESULTS
  ON lesions were detected in 32/72 patients (44%) between one and five months (3.1 months on average) after starting high dose corticosteroid treatment. No osteonecrotic lesion was newly detected from the sixth month of treatment until the end of the follow up period.
  
  
  CONCLUSIONS
  The findings suggested that the actual time of onset of ON in SLE is within the first month of high dose corticosteroid treatment.
authors.affiliation: Department of Orthopaedic Surgery, Chiba University School of Medicine, Japan. info@kamituga-hp.or.jp
authors.forename: K
authors.initials: K
authors.lastname: Oinuma
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: Y
authors.initials: Y
authors.lastname: Nawata
authors.forename: K
authors.initials: K
authors.lastname: Takabayashi
authors.forename: I
authors.initials: I
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Kamikawa
authors.forename: H
authors.initials: H
authors.lastname: Moriya
mesh_terms: D000293:Adolescent; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced / Q000175:diagnosis; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced* / Q000175:diagnosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D005938:Glucocorticoids