title: Human papillomavirus genotypes in rural Mozambique.
abstract: We studied the genotype distribution of cervical human papillomavirus (HPV) infections in an age-stratified sample of 262 women in Mozambique using the PGMYO9-PGMY11 primer system in a reverse line-blot strip-based assay with high sensitivity in type-specific amplification. Despite the low precision of the estimates, we found that HPV-16 was not the dominant type. Instead, HPV 35 was the most commonly identified genotype among HPV-positive women (16/96 [17%]) and women with cervical neoplasia (7/23 [30%]). Certain genotypes might have been under-detected in previous studies, and type-specific HPV distributions might vary across populations. Therefore, the estimated proportion of cervical neoplasia that could be prevented by an HPV-16-based vaccine could be lower than expected.
authors.forename: X
authors.initials: X
authors.lastname: Castellsagué
authors.forename: C
authors.initials: C
authors.lastname: Menéndez
authors.forename: M P
authors.initials: MP
authors.lastname: Loscertales
authors.forename: J R
authors.initials: JR
authors.lastname: Kornegay
authors.forename: F
authors.initials: F
authors.lastname: dos Santos
authors.forename: F X
authors.initials: FX
authors.lastname: Gómez-Olivé
authors.forename: B
authors.initials: B
authors.lastname: Lloveras
authors.forename: N
authors.initials: N
authors.lastname: Abarca
authors.forename: N
authors.initials: N
authors.lastname: Vaz
authors.forename: A
authors.initials: A
authors.lastname: Barreto
authors.forename: F X
authors.initials: FX
authors.lastname: Bosch
authors.forename: P
authors.initials: P
authors.lastname: Alonso
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009073:Mozambique / Q000453:epidemiology; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000235:genetics; D015995:Prevalence; D012424:Rural Population; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000235:genetics; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000235:genetics / Q000821:virology*