Hepatitis B virus nucleic acids circulating in the blood: distinct patterns in HBs carriers with hepatocellular carcinoma.
Circulating nucleic acids in serum and plasma are common in a variety of disease conditions. Here, we focus (i) on our approach for the detection of various hepatitis B virus (HBV)-related nucleic acids in liver tissue and in serum, (ii) on the progression of the chronic HBV infection, (iii) on the relation of HBV-specific nucleic acids circulating in the blood of patients with hepatocellular carcinoma, and in general (iv) on the diagnostic potential of circulating HBV nucleic acids.
Breitkreutz
R
R
Department of Virus-Host Interactions, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Zhang
W
W
Lee
M
M
Hoffmann
A
A
Tokus
M
M
Su
Q
Q
Schröder
C H
CH
D000595:Amino Acid Sequence; D006528:Carcinoma, Hepatocellular / Q000097:blood*; D002353:Carrier State; D018450:Disease Progression; D006514:Hepatitis B Surface Antigens / Q000235:genetics*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics; D054334:Viral Regulatory and Accessory Proteins
D006514:Hepatitis B Surface Antigens; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein