A facile and highly efficient route to a traceless pi-arene chromium linker. Applications to synthetic and combinatorial chemistry.
[reaction--see text] A simple and efficient method for the attachment of functionalized arene chromium carbonyls to a polymeric support has been developed. A highly efficient solid-phase synthesis of tertiary alcohols and esters was performed in a traceless manner using this strategy. The linker-fabrication protocol permits simultaneous immobilization of various substrates on the solid support.
Rigby
J H
JH
Department of Chemistry, Wayne State University, Detroit, Michigan 48202-3489, USA. jhr@chem.wayne.edu
Kondratenko
M A
MA
D000438:Alcohols / Q000138:chemical synthesis; D001555:Benzene Derivatives / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry; D002857:Chromium / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D004952:Esters / Q000138:chemical synthesis; D007202:Indicators and Reagents; D009942:Organometallic Compounds / Q000737:chemistry*; D011137:Polystyrenes; D013055:Spectrophotometry, Infrared
D000438:Alcohols; D001555:Benzene Derivatives; D002614:Chelating Agents; D004952:Esters; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D011137:Polystyrenes; D002857:Chromium