title: Asymmetric synthesis with a chiral catalyst generated from asymmetric autocatalysis.
abstract: A new and efficient one-pot system of asymmetric catalysis is presented in which a chiral catalyst (5-pyrimidyl alkanol) self-improves its ee by asymmetric autocatalysis and then acts as a highly enantioselective chiral catalyst for other asymmetric synthesis (addition of dialkylzincs to aldehydes) to provide products (sec-alcohols) with very high ee (up to 99%).[reaction: see text]
authors.affiliation: Department of Applied Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Urabe
authors.forename: S
authors.initials: S
authors.lastname: Ishii
authors.forename: S
authors.initials: S
authors.lastname: Tanji
authors.forename: K
authors.initials: K
authors.lastname: Soai