Role of cell-cell interactions in the regulation of hemopoiesis during cytostatic-induced myelosuppression.
The content of hemopoietic precursors in the bone marrow, its morphological composition, structural and functional organization, binding of hemopoietic precursors by adherent cells, and expression of receptors for erythroblasts and sialoadhesin on bone marrow macrophages were studied in CBA/CaLac mice with hypoplasia of hemopoiesis caused by etoposide in a maximum permissible dose. It was found that recovery of hemopoiesis after cytostatic treatment was related to accelerated maturation of hemopoietic precursors and increased ability of microenvironmental cells to bind hemopoietic cells.
Zhdanov
V V
VV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk.
Udut
E V
EV
Gur'yantseva
L A
LA
Danilets
M G
MG
Dygai
A M
AM
Gol'dberg
E D
ED
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002448:Cell Adhesion; D002450:Cell Communication; D002452:Cell Count; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000166:cytology / Q000502:physiology; D005047:Etoposide / Q000494:pharmacology*; D006098:Granulocytes / Q000166:cytology / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000166:cytology / Q000502:physiology; D011971:Receptors, Immunologic / Q000378:metabolism; D063267:Sialic Acid Binding Ig-like Lectin 1; D013997:Time Factors
D000972:Antineoplastic Agents, Phytogenic; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D063267:Sialic Acid Binding Ig-like Lectin 1; C571167:Siglec1 protein, mouse; D005047:Etoposide