[The elastin-laminin receptor].
Elastin is a major component of the extracellular matrix. Elastin peptides derived from its degradation are present in human sera. Elastin peptides induce on fibroblasts, phagocytic cells, lymphocytes, smooth muscle cells and endothelial cells, a variety of biological effects mediated by the elastin-laminin receptor which has been demonstrated to be present on the membrane of these cells. The transduction pathway of the ELR receptor involves the activation of phospholipase C (PLC) by a pertussis toxin sensitive G-protein. PLC induces the production of inositol trisphosphate (IP3) leading to the increase of the intracellular free calcium on one hand, and of diacylglycerol (DAG) which stimulates the translocation to the membrane of PKC leading to the phosphorylation of members of the MAPK family, such as p42/p44 MAPK. Considering the multiple biological effects of ELR the elucidation of the complexity of the signaling pathways will help to better modulate it, mainly in pathological situations such as atherosclerosis.
Fülöp
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Laboratoire de Bio-gérontologie, Institut Universitaire de Gériatrie et Département de Médecine, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Jacob
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MP
Wallach
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J
Hauck
M
M
Seres
I
I
Varga
Z
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Robert
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L
D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D004549:Elastin / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000187:drug effects; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D015603:Keratinocytes / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D020935:MAP Kinase Signaling System / Q000187:drug effects; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009363:Neoplasm Proteins / Q000502:physiology; D010455:Peptides / Q000494:pharmacology; D037342:Pertussis Toxin; D010586:Phagocytes / Q000187:drug effects; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*; D017474:Receptors, Laminin / Q000187:drug effects / Q000502:physiology*; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors / Q000378:metabolism; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D009363:Neoplasm Proteins; D010455:Peptides; D011956:Receptors, Cell Surface; D017474:Receptors, Laminin; D010566:Virulence Factors, Bordetella; C054901:elastin-binding proteins; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015544:Inositol 1,4,5-Trisphosphate; D004549:Elastin; D037342:Pertussis Toxin; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins