[Antiviral activity of 2'-deoxy-2'-fluoroguanosine against influenza and herpes simplex viruses in cultured cells].
High antiviral activity of 2'-deoxy-2'fluoroguanosine (2'-D-2'-FG) was observed in chicken embryo cells infected with FPV/Rostock/34 (H7N1) influenza virus and herpes simplex virus (HSV) type I (strain 1C). 50% inhibitory concentration (IC50) of 2'-D-2'-FG was 1.44 microM for FPV and 0.093 microM for HSV. IC50 of remantadine hydrochloride, ribavirin (FPV), and acycloguanosine (HSV) were < 0.46, 14.4, and 0.08 microM, respectively. Anti-HSV activity was confirmed in Vero cells: IC50 < 0.34 microM for 2'-D-2'-FG and IC50 < 0.044 microM for acycloguanosine.
Boreko
I
I
Pavlova
N I
NI
Zaĭtseva
G V
GV
Mikhaĭlopulo
I A
IA
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002642:Chick Embryo; D002522:Chlorocebus aethiops; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009975:Orthomyxoviridae / Q000187:drug effects*; D014709:Vero Cells
D000998:Antiviral Agents; C083670:2'-deoxy-2'-fluoroguanosine; D003849:Deoxyguanosine