title: HIV 10 Years Later - Where Do We Stand Now?. 10th international aids meeting, yokohama.
abstract: A wide variety of up-to-date results and knowledge were presented at the 10th International AIDS Meeting, Yokohama. Epidemiologically, most interest was focused on the discovery of a new HIV subtype O, which cannot be reliably detected by currently available ELISA kits. Clinically, it is gradually appreciated that one single most important parameter is the viral load; the extent of viral load can help explain many clinical observations. Another eye-catching finding was the report of a clinical follow-up of a group of long-term nonprogressors. If the underlying operative mechanism can be elucidated, we can learn the necessary elements for halting HIV infection progression. Therapeutically, the trend has shifted to combination therapy, preferentially 3-drug combination of 2 RT inhibitors and 1 protease inhibitor. For the vaccine development, many novel vectors were introduced, but their potentials are unknown at present. The successful application of single-cell in situ PCR has changed our perception of HIV infection. This powerful technique can detect a single viral genome inside cells and revealed that a large proportion of cells already harbor HIV genomes soon after the entry of HIV into the body. A direct viral effect may fully explain subsequent T cell depletion without invoking a lot of indirect mechanisms such as apoptosis. Copyright 1995 S. Karger AG, Basel
authors.affiliation: Glaxo Heritage Research Institute and Department of Medical Microbiology and Infectious Diseases, University of Alberta, Edmonton, Canada.
authors.forename: L.J.
authors.initials: LJ
authors.lastname: Chang
authors.forename: Y.-M.A.
authors.initials: YM
authors.lastname: Chen
authors.forename: M.-Y.
authors.initials: MY
authors.lastname: Chen
authors.forename: C.-C.
authors.initials: CC
authors.lastname: Chou
authors.forename: S.-J.
authors.initials: SJ
authors.lastname: Twu
authors.forename: L.-M.
authors.initials: LM
authors.lastname: Huang