Sensory adaptation in naive peripheral CD4 T cells.
T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs. Here we show that pMHC contact modulates the expression of CD5 by naive CD4 T cells in a process that requires the continued expression of p56(lck). Reduced CD5 levels in T cells deprived of pMHC contact are predictive of elevated Ca(2)+ responses to subsequent TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact may be important for regulating naive CD4 T cell responsiveness.
Smith
K
K
Lymphocyte Development Group, MRC Clinical Sciences Centre, ICSM Hammersmith Hospital, London W12 0NN, UK.
Seddon
B
B
Purbhoo
M A
MA
Zamoyska
R
R
Fisher
A G
AG
Merkenschlager
M
M
D000222:Adaptation, Physiological / Q000276:immunology*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens / Q000096:biosynthesis / Q000276:immunology; D006183:H-2 Antigens / Q000096:biosynthesis / Q000276:immunology; D006239:Haplotypes; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000096:biosynthesis / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D051379:Mice
D018956:CD5 Antigens; D006183:H-2 Antigens; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)