Management of pregnancy with congenital antithrombin III deficiency: two case reports and a review of the literature.
Women with antithrombin (AT) III deficiency are prone to pregnancy-associated venous thromboembolism. We report 2 cases with genetically confirmed ATIII deficiency, one with a mutation in exon 3A and the other with an exon 4 deletion, in whom the pregnancies were successfully managed with prophylactic therapies for thrombosis. A 35-year-old pregnant woman was treated with intravenous infusions of ATIII concentrate alone, and the other 22-year-old pregnant woman was mainly treated with subcutaneous injections of heparin and oral low-dose aspirin therapy. Both pregnancies resulted in vaginal deliveries of healthy neonates. The literature concerning prophylactic therapies for thrombosis in ATIII deficiency-complicated pregnancy is reviewed, and the clinical problems, including the adverse effects of the therapies, are discussed.
Yamada
T
T
Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Japan.
Yamada
H
H
Morikawa
M
M
Kato
E H
EH
Kishida
T
T
Ohnaka
Y
Y
Nikaido
H
H
Ozawa
T
T
Fujimoto
S
S
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D020152:Antithrombin III Deficiency / Q000097:blood / Q000151:congenital / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy*; D013927:Thrombosis / Q000517:prevention & control*
D000925:Anticoagulants