Ultrastructural and biosynthetic characteristics of epidermal cells in patients with psoriasis treated with antiproliferative drugs.
Biopsy specimens from patients with psoriasis treated with antiproliferative drugs (methotrexate, etretinate) were analyzed. Acanthosis and papillomatosis of the epidermis and inflammatory reaction of the derma decreased. A tendency to normalization of epidermocyte ultrastructure with regeneration of tonofilaments and normal keratinization was noted. An important role in the morphogenesis of this process belongs to interrelationships of two competitive types of biosynthesis, DNA and RNA synthesis, providing epidermocyte proliferation and intracellular regeneration, respectively. Structural and functional composition optimal for the epidermis is formed under conditions of complex treatment with antiproliferative drugs combined with photochemotherapy.
Krinitsyna
Y M
YM
Laboratory of ultrastructural bases of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk. pathol@cyber.ma.nsc.ru
Nepomnyashchikh
G I
GI
Aidagulova
S V
SV
D001706:Biopsy; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure*; D005050:Etretinate / Q000627:therapeutic use; D006131:Growth Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007382:Intermediate Filaments / Q000648:ultrastructure; D008727:Methotrexate / Q000627:therapeutic use; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D012313:RNA / Q000096:biosynthesis
D006131:Growth Inhibitors; D012313:RNA; D005050:Etretinate; D004247:DNA; D008727:Methotrexate