Hantavirus infections and their prevention.
Hantaviruses are rodent-borne bunyaviruses which cause haemorrhagic fever with renal syndrome and Hantavirus pulmonary syndrome in humans. This review covers the host interactions of the viruses, including the rodent reservoirs, the clinical outcome of human infections as well as the pathogenesis and laboratory diagnosis of infections. The current stage in prophylaxis and therapy of hantaviral diseases is described and different approaches in vaccine development are discussed.
Krüger
D H
DH
Institute of Virology, Humboldt University, School of Medicine Charité, D-10098, Berlin, Germany. detlev.kruger@charite.de
Ulrich
R
R
Lundkvist A
A
A
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004197:Disease Reservoirs; D006476:Orthohantavirus / Q000502:physiology*; D018778:Hantavirus Infections / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D006790:Host-Parasite Interactions; D006801:Humans; D014765:Viral Vaccines / Q000276:immunology
D000998:Antiviral Agents; D014765:Viral Vaccines