Metabolism of biogenic amines in rat brain during pilocarpine-induced aggression.
Quantitative distribution of bioactive substances in the brain of aggressive rats was studied. The norepinephrine/serotonin ratio increased in the temporal and parietal lobes, hypothalamus, and hippocampus of killer rats. The open filed behavior of aggressive rats is characterized by a long latency period, low locomotor activity, and slow movements. Exposure to constant darkness aggravated abnormal behavioral characteristics of aggressive rats. Serotonin content in the hypothalamus and visual cortex of these rats decreased by 75 and 76%, respectively.
Aleksidze
N G
NG
I. Dzhavakhishvili Tbilisi State University.
Goguadze
R P
RP
Mikiashvili
N A
NA
Chipashvili
M D
MD
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003624:Darkness; D006624:Hippocampus / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D007031:Hypothalamus / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D010296:Parietal Lobe / Q000187:drug effects / Q000378:metabolism; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D013702:Temporal Lobe / Q000187:drug effects / Q000378:metabolism
D001679:Biogenic Amines; D010862:Pilocarpine; D012701:Serotonin