LMP1-induced downregulation of CD99 molecules in Hodgkin and Reed-Sternberg cells.
Hodgkin's and Reed-Sternberg (H-RS) cells are morphological hallmarks of Hodgkin's disease (HD). So far, several characteristics frequently seen in H-RS cells from different origins have been described, such as the high expression of Epstein-Barr virus latent membrane protein 1 (LMP1), the elevation of NF-kappaB activity, and the aberrant expression of molecules such as CD15, CD30, and CD99. Despite extensive studies on the nature of H-RS cells, the molecular mechanism by which H-RS cells are generated remained elusive. Recently, the forced down-regulation of CD99 was reported to induce typical H-RS phenotypes in vitro in a B cell line. Furthermore, it was revealed that LMP1 markedly reduces the CD99 expression at the transcriptional level. Since the presence of LMP1 is known to be associated with the H-RS cell formation, the data provide a possibility of linkage between LMP1 and HD via CD99, thus suggesting that, at least in part, the loss of CD99 may play a critical role in the pathogenic sequence to the formation of H-RS cells in HD. In this review, the role of CD99 in the generation of H-RS cells and its molecular mechanism will be suggested.
Lee
I S
IS
Department of Pathology, Seoul National University College of Medicine, Korea.
Shin
Y K
YK
Chung
D H
DH
Park
S H
SH
D000071443:12E7 Antigen; D015703:Antigens, CD / Q000187:drug effects* / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000187:drug effects* / Q000235:genetics; D015536:Down-Regulation / Q000187:drug effects; D004854:Herpesvirus 4, Human / Q000737:chemistry; D006689:Hodgkin Disease / Q000209:etiology* / Q000473:pathology / Q000821:virology; D006801:Humans; D016539:Reed-Sternberg Cells / Q000473:pathology / Q000821:virology*; D014158:Transcription, Genetic / Q000187:drug effects; D014763:Viral Matrix Proteins / Q000494:pharmacology* / Q000502:physiology
D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins