title: Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.
abstract: The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throughout the world has prompted a search for new, safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(alpha-D-arabinofuranosyl)-alpha-D-arabinofuranoside analogues were synthesized and evaluated as inhibitors for M. tuberculosis and Mycobacterium avium. A cell free assay system has been used for the evaluation of these disaccharides as substrates for mycobacterial arabinosyltransferase activity.
authors.affiliation: Department of Organic Chemistry, Southern Research Institute, PO Box 55305, Birmingham, AL 35255, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Pathak
authors.forename: V
authors.initials: V
authors.lastname: Pathak
authors.forename: J A
authors.initials: JA
authors.lastname: Maddry
authors.forename: W J
authors.initials: WJ
authors.lastname: Suling
authors.forename: S S
authors.initials: SS
authors.lastname: Gurcha
authors.forename: G S
authors.initials: GS
authors.lastname: Besra
authors.forename: R C
authors.initials: RC
authors.lastname: Reynolds
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D002236:Carbohydrate Conformation; D004187:Disaccharides / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D009162:Mycobacterium avium / Q000187:drug effects / Q000201:enzymology; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology*; D010430:Pentosyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D004187:Disaccharides; D010430:Pentosyltransferases; C101967:arabinosyltransferase