title: Synonymous codon usage in bacteria.
abstract: In most bacteria, synonymous codons are not used with equal frequencies. Different factors have been proposed to contribute to codon usage preference, including translational selection, GC composition, strand-specific mutational bias, amino acid conservation, protein hydropathy, transcriptional selection and even RNA stability. The review discusses these factors and their contribution to bias in synonymous codon usage in bacterial genomes.
authors.affiliation: The Institute for Genomic Research, Rockville, MD 20850, USA. mariae@tigr.org
authors.forename: M D
authors.initials: MD
authors.lastname: Ermolaeva
mesh_terms: D001419:Bacteria / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics; D001482:Base Composition; D003062:Codon / Q000235:genetics*; D014176:Protein Biosynthesis
chemical_list: D001426:Bacterial Proteins; D003062:Codon