title: Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.
abstract: Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.
authors.affiliation: CeNeS Pharmaceuticals Inc., 333 Providence Highway, Norwood, MA 02062, USA. padman12@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Padmanabhan
authors.forename: R C
authors.initials: RC
authors.lastname: Lavin
authors.forename: P M
authors.initials: PM
authors.lastname: Thakker
authors.forename: J
authors.initials: J
authors.lastname: Guo
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Moore
authors.forename: M E
authors.initials: ME
authors.lastname: Perlman
authors.forename: C
authors.initials: C
authors.lastname: Kirk
authors.forename: D
authors.initials: D
authors.lastname: Daly
authors.forename: K J
authors.initials: KJ
authors.lastname: Burke-Howie
authors.forename: T
authors.initials: T
authors.lastname: Wolcott
authors.forename: S
authors.initials: S
authors.lastname: Chari
authors.forename: D
authors.initials: D
authors.lastname: Berlove
authors.forename: J B
authors.initials: JB
authors.lastname: Fischer
authors.forename: W F
authors.initials: WF
authors.lastname: Holt
authors.forename: G J
authors.initials: GJ
authors.lastname: Durant
authors.forename: R N
authors.initials: RN
authors.lastname: McBurney
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D019791:Guanidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D008811:Mice, Inbred DBA; D026941:Sodium Channel Blockers
chemical_list: D026941:Sodium Channel Blockers; D019791:Guanidine