Chronic interstitial nephritis following parenteral copper sulfate poisoning.
A 21-year-old male patient was admitted with acute renal failure and intravascular hemolysis following suicidal parenteral copper sulfate poisoning. He developed metabolic acidosis and septicemia; and was treated with intensive hemodialysis, blood transfusions and antibiotics. After remaining anuric for 4 weeks, his urine output gradually increased. However his renal functions improved only partially. Renal biopsy done 8 weeks after the episode showed chronic tubulo-interstitial nephritis (CIN). This is the first reported case showing CIN following acute copper sulfate intoxication.
Bhowmik
D
D
Department of Nephrology, All India Institute of Medical Sciences, New Delhi.
Mathur
R
R
Bhargava
Y
Y
Dinda
A K
AK
Agarwal
S K
SK
Tiwari
S C
SC
Dash
S C
SC
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001707:Biopsy, Needle; D001803:Blood Transfusion / Q000379:methods; D002908:Chronic Disease; D003131:Combined Modality Therapy; D019327:Copper Sulfate / Q000506:poisoning*; D004638:Emergency Treatment / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D007262:Infusions, Intravenous; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology* / Q000628:therapy; D006435:Renal Dialysis / Q000379:methods; D013406:Suicide, Attempted; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D019327:Copper Sulfate