Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.
Combination antimalarial therapy is being explored to delay development of resistance to falciparum malaria. This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate. Use of these combinations should be closely monitored.
Orrell
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Department of Pharmacology, University of Cape Town, Cape Town, South Africa. hivunit@bigfoot.com
Taylor
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WR
Olliaro
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P
D000328:Adult; D000655:Amodiaquine / Q000009:adverse effects*; D000962:Antimalarials / Q000009:adverse effects*; D037621:Artemisinins; D000077332:Artesunate; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology*; D018592:Cross-Over Studies; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology; D016778:Malaria, Falciparum / Q000188:drug therapy; D012717:Sesquiterpenes / Q000009:adverse effects*
D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D012717:Sesquiterpenes; D000655:Amodiaquine; D000077332:Artesunate