Memory impairment in schizophrenia: a study using event-related potentials in implicit and explicit tasks.
Although memory impairment is recognized as a major fact of schizophrenia, only a few studies have investigated memory impairments with specifically designed event-related potential (ERP) protocols. In this study, ERPs were recorded from 15 schizophrenia patients and 15 matched control subjects during implicit and explicit memory tasks for unfamiliar faces. The results showed that patients have a reduced modulation of an N400-like component in both the implicit and explicit tasks that suggests a deficient integration of incoming information with personal knowledge. Patients also displayed an enhanced frontally distributed activity in the explicit task that may represent an impairment in the integration of intrinsic contextual information, a disturbance in the ability to inhibit proactive interference or a combination of both processes. Finally, the modulation of the late positive component did not differ from that in control subjects in both implicit and explicit tasks, suggesting that the impairment in mnemonic binding processes suggested in schizophrenia is more qualitative, i.e. incomplete or inappropriate, due to the anomalies in antecedent processes. The correlations observed between impairments of ERP modulation and symptoms further support these interpretations.
Guillem
F
F
Douglas Hospital Research Centre-Clinical Unit, Quebec, Verdun, Canada. fguillem@crfs.umontreal.ca
Bicu
M
M
Hooper
R
R
Bloom
D
D
Wolf
M A
MA
Messier
J
J
Desautels
R
R
Debruille
J B
JB
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000502:physiology; D005145:Face; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology