title: Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes.
abstract: Eight carbohydrate-pendant platinum(II) complexes have been synthesized from carbohydrate-diamine conjugates. D-Glucose, D-mannose, D-galactose, D-xylose, and L-glucose are attached to the dichloroplatinum(II) moiety by 1,3- or 1,2-diaminopropane chelates through with an O-glycoside bond. All the carbohydrate moieties reduced the toxicity inherent with platinum(II) complexes.
authors.affiliation: KYOUSEI Science Center, Nara Women's University, Nara 630-8506, Japan. mikata@cc.nara-wu.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Mikata
authors.forename: Y
authors.initials: Y
authors.lastname: Shinohara
authors.forename: K
authors.initials: K
authors.lastname: Yoneda
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: I
authors.initials: I
authors.lastname: Brudziñska
authors.forename: T
authors.initials: T
authors.lastname: Tanase
authors.forename: T
authors.initials: T
authors.lastname: Kitayama
authors.forename: R
authors.initials: R
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.forename: I
authors.initials: I
authors.lastname: Kinoshita
authors.forename: M
authors.initials: M
authors.lastname: Doe
authors.forename: C
authors.initials: C
authors.lastname: Orvig
authors.forename: S
authors.initials: S
authors.lastname: Yano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C448381:2-glucose-diaminopropane-dichloroplatinum(II); D000970:Antineoplastic Agents; D002241:Carbohydrates; D009944:Organoplatinum Compounds; D002945:Cisplatin