Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice.
Serotonergic and dopaminergic involvement in hyperthermia induced by a serotonin (5-hydroxytryptamine, 5-HT)-releasing drug, p-chloroamphetamine, was investigated in mice. Neither the 5-HT transporter inhibitor fluoxetine nor the 5-HT depleter p-chlorophenylalanine affected p-chloroamphetamine-induced hyperthermia. The dopamine depleter alpha-methyl-p-tyrosine significantly reduced p-chloroamphetamine-induced hyperthermia. The dopamine D(1) receptor antagonist 7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SCH 23390) antagonized p-chloroamphetamine-induced hyperthermia, although the dopamine D(2) receptor antagonist sulpiride was without effect. These results indicate that p-chloroamphetamine-induced hyperthermia in mice is mediated by dopamine release followed by activation of the dopamine D(1) receptor.
Sugimoto
Y
Y
Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, 658-8558, Kobe, Japan. yumisugi@kobepharma-u.ac.jp
Ohkura
M
M
Inoue
K
K
Yamada
J
J
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D018492:Dopamine Antagonists / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D051379:Mice; D011954:Receptors, Dopamine / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D018490:Serotonin Agents / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D013469:Sulpiride / Q000494:pharmacology; D013997:Time Factors; D019805:alpha-Methyltyrosine / Q000494:pharmacology; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D001552:Benzazepines; D018492:Dopamine Antagonists; D004791:Enzyme Inhibitors; D010134:Fenclonine; D005473:Fluoxetine; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D018490:Serotonin Agents; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; D013469:Sulpiride; D019805:alpha-Methyltyrosine; D010133:p-Chloroamphetamine