Fulminant hepatic failure secondary to adenovirus following fludarabine-based chemotherapy for non-Hodgkin's lymphoma.
Self-limited adenoviral infections are very common with the majority of infections resolving rapidly. Fatal complications may occur in severely immunocompromised patients. We describe a case of fulminant hepatic failure due to adenovirus in a 54-year-old man treated with fludarabine and cyclophosphamide for non-Hodgkin's lymphoma. There are no previous reports of this complication in conjunction with purine nucleoside therapy.
Hogan
W J
WJ
Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Edwards
W D
WD
Macon
W R
WR
Habermann
T M
TM
D000257:Adenoviridae Infections / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001344:Autopsy; D017809:Fatal Outcome; D006801:Humans; D017093:Liver Failure / Q000209:etiology* / Q000473:pathology / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity*
D014740:Vidarabine; C024352:fludarabine