Involvement of NPY Y2 receptor subtype in the control of the spontaneous NO/GnRH release at the rat median eminence.
The role of nitric oxide (NO) from vascular endothelium in the control of GnRH release at the median eminence (ME) level is well established. Interactions between NPY receptor/endothelium/nitric oxide are clearly demonstrated. While several studies implicate NPY Y1 receptor in the control of GnRH/LH at the time of the preovulatory LH surge, our results also demonstrate the importance of NPY Y2 receptor in the control of GnRH release via endothelial NO. We conclude that NPY may be one of the elements implicated in the generation of the spontaneous NO/GnRH via Y2 receptor located on endothelium.
Knauf
C
C
INSERM U422, IFR22, Unité de Neuroendocrinologie et Physiopathologie Neuronale, 1 Place de Verdun, 59045 Lille Cedex, France.
Chuoï
M M
MM
Jirou-Najou
J L
JL
Mortreux
G
G
Beauvillain
J C
JC
Croix
D
D
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001552:Benzazepines / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D008473:Median Eminence / Q000187:drug effects / Q000378:metabolism*; D009478:Neuropeptide Y / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D014151:Anti-Anxiety Agents; C092926:BIBP 3226; D001552:Benzazepines; D009478:Neuropeptide Y; D012333:RNA, Messenger; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; C095889:neuropeptide Y2 receptor; D009569:Nitric Oxide; D007987:Gonadotropin-Releasing Hormone; D001120:Arginine; C403256:BIIE 0246