title: Paradoxical role of Helicobacter pylori infection: protective effect against ethanol-induced gastric mucosal injury in Mongolian gerbils.
abstract: We investigated the effect of ethanol (a representative necrotizing agent) on gastritis induced by Helicobacter pylori infection in Mongolian gerbils. Seventy-eight gerbils were used. Four and 12 weeks after H. pylori inoculation, 30% ethanol was administered into the stomach. The stomachs were removed after 30 min, the intramucosal prostaglandin (PG) E2 concentration was measured, and histopathology was recorded. H. pylori infection caused chronic active gastritis, gastric erosion, hypersecretion of mucin from gland mucus cells, and a rise in the activity of intramucosal PGE2. After ethanol administration, gastric erosion was significantly less in animals infected with H. pylori than in uninfected animals. In conclusion, in the early stage of H. pylori infection, accentuation of intramucosal PGE2 and hypersecretion of mucin from gland mucus cells have a protective effect against gastric mucosal injury induced by necrotizing agents.
authors.affiliation: First Department of Surgery, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Ikeno
authors.forename: K
authors.initials: K
authors.lastname: Ishida
authors.forename: F
authors.initials: F
authors.lastname: Maruta
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Ishizone
authors.forename: S
authors.initials: S
authors.lastname: Kawasaki
authors.forename: H
authors.initials: H
authors.lastname: Ota
authors.forename: T
authors.initials: T
authors.lastname: Katsuyama
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects*; D005752:Gastric Mucins / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000139:chemically induced* / Q000382:microbiology* / Q000473:pathology; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000473:pathology / Q000503:physiopathology*; D016480:Helicobacter pylori; D008297:Male
chemical_list: D005752:Gastric Mucins; D000431:Ethanol; D015232:Dinoprostone