title: [Analysis of the action of dextran sulfate as a prophylaxis for peritoneal cancer metastasis, and its acting mechanism].
abstract: Although peritoneal cancer metastasis has the highest frequency of postoperative recurrence among digestive organ malignant tumors, there is no still decisive treatment. Dextran sulfate (DS) as a prophylaxis for cancer metastasis was examined with respect to its effect on cultured cells. DS was made to act on a strong adhesive neoplasm cell, and the action and acting mechanism were examined with respect to 1. readhesiveness, 2. cell cycle, and 3. gene analysis. The results suggest that: i) Once tumor cells are detached by DS, the free cells do not attach even when DS is removed, and ii) DS causes the cells to stop in the G1/G0 phase.
authors.affiliation: Dept. of Digestive Surgery, Kyoto Prefectural University of Medicine.
authors.forename: J
authors.initials: J
authors.lastname: Fujiyama
authors.forename: C
authors.initials: C
authors.lastname: Sakakura
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Takemura
authors.forename: A
authors.initials: A
authors.lastname: Touma
authors.forename: K
authors.initials: K
authors.lastname: Shimomura
authors.forename: H
authors.initials: H
authors.lastname: Yunning
authors.forename: H
authors.initials: H
authors.lastname: Longhai
authors.forename: H
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: J
authors.initials: J
authors.lastname: Yamasaki
authors.forename: E
authors.initials: E
authors.lastname: Otsuji
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: H
authors.initials: H
authors.lastname: Yamagishi
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D016264:Dextran Sulfate / Q000494:pharmacology* / Q000627:therapeutic use; D008546:Melanoma, Experimental / Q000235:genetics / Q000473:pathology*; D051379:Mice; D010534:Peritoneal Neoplasms / Q000517:prevention & control* / Q000556:secondary*
chemical_list: D016264:Dextran Sulfate