Possible levofloxacin-induced acute hepatocellular injury in a patient with chronic obstructive lung disease.
Levofloxacin is one of the most commonly prescribed antibiotics for both inpatient and outpatient care of respiratory tract infection. It is generally well tolerated, and it has an excellent safety profile. We report a case of severe acute liver toxicity that apparently complicated intravenous administration of levofloxacin, which resolved after discontinuation of the drug.
Karim
A
A
Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, Long Island Campus of the Albert Einstein College of Medicine, Bronx, NY 11040, USA.
Ahmed
S
S
Rossoff
L J
LJ
Siddiqui
R K
RK
Steinberg
H N
HN
D000208:Acute Disease; D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D064704:Levofloxacin; D008099:Liver / Q000187:drug effects* / Q000293:injuries; D008107:Liver Diseases / Q000209:etiology*; D008111:Liver Function Tests; D015242:Ofloxacin / Q000009:adverse effects*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin