title: Trichotillomania. Presentation, etiology, diagnosis and therapy.
abstract: Trichotillomania (TTM) is an impulse disorder, in which patients chronically pull hair from the scalp and/or other sites. Very early onset of hair pulling in children under the age of 6 may be more benign and self-limiting than the more common syndrome of late childhood onset hair pulling. While far more women and adolescent girls appear for treatment, survey studies suggest chronic hair pulling also occurs in males. Diagnosis may be complicated by patient and family denial or ignorance of the hair pulling; accurate scalp examination and biopsy can be critical. Classic scalp biopsies for TTM feature trichomalacia, pigment clumps, peribulbar hemorrhage and hair canal pigment casts, and lack lymphocytic infiltrates seen in alopecia areata. Treatment is difficult: the tricyclic antidepressant clomipramine is the most promising agent, although many patients find it difficult to tolerate at adequate dosages, and treatment response may not be maintained over the long term. More benign medications have not demonstrated efficacy in controlled studies. Augmentation with topical preparations or psychotropic medications may be helpful for patients experiencing limited efficacy or relapse. Specialized psychotherapy, known as habit reversal training, is highly recommended; however, the treatment is intensive and highly specialized. Skilled therapists are difficult to locate.
authors.affiliation: Indiana University School of Medicine, Indianapolis, Indiana, USA. kewalsh@iupui.edu
authors.forename: K H
authors.initials: KH
authors.lastname: Walsh
authors.forename: C J
authors.initials: CJ
authors.lastname: McDougle
mesh_terms: D000293:Adolescent; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001706:Biopsy / Q000379:methods; D002648:Child; D002675:Child, Preschool; D002997:Clomipramine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011613:Psychotherapy / Q000379:methods; D014256:Trichotillomania / Q000175:diagnosis / Q000628:therapy*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine