GvHD risk assessment in hematopoietic stem cell transplantation: role of cytokine gene polymorphisms and an in vitro human skin explant model.
This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor alpha, interferon gamma, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in predicting outcome and the development of a genetic risk index for graft-versus-host disease in human leukocyte antigen matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain polymorphisms may be associated with more severe disease.
Dickinson
A M
AM
University Department of Haematology, Tyneside Leukaemia Research Laboratory, Royal Victoria Infirmary, Newcastle-upon-Tyne, United Kingdom.
Cavet
J
J
Cullup
H
H
Wang
X N
XN
Sviland
L
L
Middleton
P G
PG
D016026:Bone Marrow Transplantation / Q000009:adverse effects; D016207:Cytokines / Q000235:genetics*; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012867:Skin / Q000473:pathology*
D016207:Cytokines