Structural and rheological properties of methacrylamide modified gelatin hydrogels.
Dynamic shear oscillation measurements at small strain were used to characterize the viscoelastic properties and related differences in the molecular structure of hydrogels based on gelatin methacrylamide. Gelatin was derivatized with methacrylamide side groups and was subsequently cross-linked by radical polymerization via photoinitiation. The light treatment of methacrylamide gelatin solutions resulted in the production of hydrogel films with high storage modulus (G'). Mechanical spectra and thermal scanning rheology of the obtained hydrogels are described. The temperature scan of the network below and above melting point of gelatin allowed us to identify the respective contributions of chemical and physical cross-linkage to the hydrogel elastic modulus. The results indicate that the rheological properties of the gelatin-based hydrogels can be controlled by the degree of substitution, polymer concentration, initiator concentration, and UV irradiation conditions.
Van Den Bulcke
A I
AI
Department of Organic Chemistry, Polymer Materials Research Group, Institute of Biomedical Technologies (IBITECH), University of Ghent, Krijgslaan 281, S4-bis, B-9000 Ghent, Belgium.
Bogdanov
B
B
De Rooze
N
N
Schacht
E H
EH
Cornelissen
M
M
Berghmans
H
H
D000178:Acrylamides / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003432:Cross-Linking Reagents; D005780:Gelatin / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D012212:Rheology; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
D000178:Acrylamides; D003432:Cross-Linking Reagents; D020100:Hydrogels; D005780:Gelatin; C045985:methacrylamide