Cacofurans A and B, new furanoditerpenes from a marine sponge.
Two new labdane-class diterpenes, cacofurans A (1) and B (2), have been isolated from a sponge Cacospongia sp. Their structures were determined by analyzing spectroscopic data, by chemical transformations, and by X-ray diffraction. Cacofurans 1 and 2 inhibited the development of fertilized sea urchin eggs at concentrations of 0.5 and 5 microg/mL and showed an actin-disrupting effect on the NBT-II cell line at 10 microg/mL.
Tanaka
J
J
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. jtanaka@sci.u-ryukyu.ac.jp
Marriott
G
G
Higa
T
T
Higa
T
T
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D027722:Convolvulaceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D007945:Leukemia, Lymphoid; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D012617:Sea Urchins / Q000187:drug effects / Q000196:embryology; D013094:Spermatozoa / Q000187:drug effects; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects; D001749:Urinary Bladder Neoplasms; D014961:X-Ray Diffraction
D004224:Diterpenes; D005663:Furans; C442603:cacofuran A; C442604:cacofuran B