title: Sensorineural hearing loss in linear IgA disease.
abstract: A 23-year-old female with progressive sensorineural hearing loss developed widespread blistering eruptions while under evaluation for the hearing loss. The lesions showed findings characteristic of linear IgA disease (LAD) on histochemical studies. Linear IgA disease is a dapsone responsive autoimmune subepidermal blistering disease characterised by linear IgA deposits in the basement membrane zone. The complete spectrum of this systemic disease is still not clear and this is the first report of association between LAD and sensorineural deafness.
authors.affiliation: Department of Otolaryngology, Southmead Hospital, Bristol.
authors.forename: C K
authors.initials: CK
authors.lastname: Hari
authors.forename: J
authors.initials: J
authors.lastname: Hanif
authors.forename: A
authors.initials: A
authors.lastname: Frosh
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone / Q000379:methods; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D001485:Basement Membrane; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A