Hodgkin lymphoma in a renal transplant recipient associated with low peripheral blood Epstein-Barr virus genome copies.
Posttransplant lymphoproliferative disorders are often accompanied by >500 Epstein-Barr virus (EBV) genome copies/10(5) lymphocytes, and they occur shortly after transplantation. Hodgkin lymphoma occurs rarely after transplantation, appearing a mean of 4.2 years posttransplant, and although Hodgkin lymphoma has strong associations with EBV, no quantitative analysis of peripheral blood EBV genome copies has been reported. A mixed cellularity Hodgkin lymphoma developed in a 17-year-old boy 4 years after a renal transplant. Serial EBV genome copy numbers from blood by competitive polymerase chain reaction had been obtained to assess for lymphoproliferative disease. Epstein-Barr virus genome copy numbers peaked at 500 copies/10(5) lymphocytes 8 months prior to Hodgkin lymphoma diagnosis but fell to 8 copies/10(5) lymphocytes at diagnosis. Reliance on EBV levels greater than 500 copies may result in delay of biopsy and diagnosis of Hodgkin disease in the posttransplant setting.
Craver
R D
RD
Department of Pathology, Louisiana State University Medical Center, New Orleans, LA, USA. rcrave@lsuhsc.edu
Scheer
W D
WD
Correa
H
H
Vehaskari
V M
VM
Yu
L C
LC
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000276:immunology; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016030:Kidney Transplantation / Q000009:adverse effects*; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000821:virology; D008297:Male; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood*; D016539:Reed-Sternberg Cells / Q000473:pathology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral