title: Treatment of extensive toxic epidermal necrolysis in children.
abstract: OBJECTIVE
  Toxic epidermal necrolysis (TEN) is a rare but life-threatening disease of the skin and mucous membranes. We report our experience in the treatment of pediatric TEN patients with early debridement of necrotic skin and coverage with human allograft skin.
  
  
  METHODS
  From 1984 to 2000, 15 children (6 girls, 9 boys, 7.2 +/- 1.5 years) with a histologic diagnosis of TEN and involvement of >30% total body surface area were treated at the Shriners Hospitals for Children in Galveston. All were treated in a specialized pediatric burn intensive care unit after our standard treatment protocol, including operative debridement of sloughing skin and allografting within 24 hours of admission. Outcome parameters were mortality, length of hospital stay, wound healing, clinical complications, causative drugs, corticosteroid use, and delay in referral to a burn center.
  
  
  RESULTS
  Taking a new medication (antibiotics, anticonvulsive drugs) was associated with all cases of TEN. Patients who were treated with early debridement and coverage with allograft skin showed no wound infection, and overall mortality was 7%. Total length of hospital stay was 26 +/- 3 days. Long-term sequelae were changes in skin pigmentation (100%), ophthalmologic problems (40%), and diffuse itching early after wound healing (53%).
  
  
  CONCLUSIONS
  Although a rare disease in children, TEN was managed successfully in a burn center environment, using early debridement and wound coverage with allograft skin as a biological dressing. The use of corticosteroids and referral patterns seems unchanged during the past 2 decades, indicating an additional need for information and education about the disease.
authors.affiliation: Shriners Hospitals for Children, Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550-2725, USA. maspies@utmb.edu
authors.forename: M
authors.initials: M
authors.lastname: Spies
authors.forename: A P
authors.initials: AP
authors.lastname: Sanford
authors.forename: J F
authors.initials: JF
authors.lastname: Aili Low
authors.forename: S E
authors.initials: SE
authors.lastname: Wolf
authors.forename: D N
authors.initials: DN
authors.lastname: Herndon
mesh_terms: D002648:Child; D003646:Debridement / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D016038:Skin Transplantation / Q000379:methods*; D013262:Stevens-Johnson Syndrome / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D014184:Transplantation, Homologous