title: Cell degeneration in the model system Podospora anserina.
abstract: Podospora anserina is a filamentous fungus used in many studies of fundamental cell biology, including cell ageing. In this organism, ageing is defined as a diminution of cell ability to proliferate and/or differentiate. This may or may not culminate with cell death. Two different ageing processes are intensively studied. The 'Senescence' phenomenon is present in all wild-type strains, results in cell death and is caused by a yet undefined cytoplasmic and infectious element. It is associated with extensive mitochondrial DNA modifications. Longevity of the strains is controlled by a highly complex network of genes. Among these, those involved in cytosolic translation and respiratory metabolism are of special importance. The 'Crippled Growth' phenomenon is present only in strains with elevated translational accuracy. It does not result in cell death but in a severe impairment of cell growth, an acceleration of Senescence and a diminution of differentiation potencies. No mitochondrial DNA modification is associated with Crippled Growth. Another cytoplasmic and infectious element with peculiar properties, C, is causally involved in the set up of this cell degeneration. The study of P. anserina degenerative processes provides a conceptual framework to understand ageing in more complex organisms. Especially, it emphasises the complex control exerted by genes on longevity, the multiplicity of degenerative processes that may occur to cells with identical genotype and the potential role of non-conventional infectious elements in cell ageing.
authors.affiliation: Institut de Génétique et Microbiologie, CNRS UMR 8621, Bât. 400 Université de Paris Sud, Orsay, France. silar@igmors.u-psud.fr
authors.forename: P
authors.initials: P
authors.lastname: Silar
authors.forename: H
authors.initials: H
authors.lastname: Lalucque
authors.forename: C
authors.initials: C
authors.lastname: Vierny
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D008954:Models, Biological; D020037:Sordariales / Q000254:growth & development / Q000502:physiology*