title: High cervical spinal cord stimulation (CSCS) increases regional cerebral blood flow after induced subarachnoid haemorrhage in rats.
abstract: The effects of high cervical spinal cord stimulation (cSCS) on regional cerebral blood flow (rCBF) were investigated after experimentally induced subarachnoid haemorrhage (SAH) in rats by the means of (99m)Tc-HMPAO. The experiments were carried out on a total of 24 Wistar rats, divided in three groups [group I: control without SAH, group II: SAH, group III: SAH and cSCS]. (99m)Tc-HMPAO was administered intravenously (group II/group III) 48 hours after induction of SAH. In group III, (99m)Tc-HMPAO was given after 3 hours of cSCS. All animals were sacrificed 30 minutes after application on (99m)Tc-HMPAO. Radioactivities were determined in blood, cerebrum and cerebellum. The ratio cerebrum/blood and cerebellum/blood was calculated to ascertain "extraction rate" in the sample differentially. The following mean values were calculated for the cerebellum/blood ratio: Group I: 1.06, SD: 0.21; Group II: 0.66, SD: 0.21; Group III: 1.00, SD: 0.37. Comparing the mean values a highly significant difference could be found between group II and III (p = 0.007) and between group I and II (p = 0.0019), respectively. Calculations of the cerebrum/blood ratio revealed similar results. After SAH cSCS enhances cerebral and cerebellar blood flow in rats. Possibly, cSCD constitutes a new therapeutic approach in the treatment of disturbed regional cerebral blood flow after SAH.
authors.affiliation: Department of Neurosurgery, University of Cologne, Germany. heinrich.ebel@t-online.de
authors.forename: H
authors.initials: H
authors.lastname: Ebel
authors.forename: K
authors.initials: K
authors.lastname: Schomäcker
authors.forename: A
authors.initials: A
authors.lastname: Balogh
authors.forename: M
authors.initials: M
authors.lastname: Volz
authors.forename: J
authors.initials: J
authors.lastname: Funke
authors.forename: H
authors.initials: H
authors.lastname: Schicha
authors.forename: N
authors.initials: N
authors.lastname: Klug
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000098:blood supply*; D004195:Disease Models, Animal; D004558:Electric Stimulation; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000502:physiology; D013116:Spinal Cord / Q000503:physiopathology*; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*; D020301:Vasospasm, Intracranial / Q000503:physiopathology