Dietary D-psicose, a C-3 epimer of D-fructose, suppresses the activity of hepatic lipogenic enzymes in rats.
D-Psicose (D-ribo-2-hexulose), a C-3 epimer of D-fructose, is present in small quantities in commercial carbohydrate complexes or agricultural products. Wistar male rats were fed experimental diets which consisted of 5% D-psicose, cellulose, D-fructose or D-glucose for 28 days. Abdominal adipose tissue weight was significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed a D-fructose and D-glucose diets, even though the four dietary groups were offered the same amount throughout the experimental period. Fatty acid synthase and glucose 6-phosphate dehydrogenase activities in the liver were significantly lower (P < 0.05) in rats fed the D-psicose diet than in rats fed the D-fructose and D-glucose diets. However, lipoprotein lipase activities in the heart, soleus muscle and perirenal adipose tissue were the same. These results suggest that a supplement of D-psicose in the diet suppresses hepatic lipogenic enzyme activities. The lower abdominal fat accumulation in rats fed a D-psicose diet might result from lower lipogenesis in the liver.
Matsuo
T
T
Faculty of Agriculture, Kagawa University, Kita-gun, Japan. matsuo@ag.kagawa-u.ac.jp
Baba
Y
Y
Hashiguchi
M
M
Takeshita
K
K
Izumori
K
K
Suzuki
H
H
D000005:Abdomen; D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D064429:Fatty Acid Synthases / Q000378:metabolism*; D005632:Fructose / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
C003243:psicose; D005632:Fructose; D005954:Glucosephosphate Dehydrogenase; D064429:Fatty Acid Synthases; D005947:Glucose