title: Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls.
abstract: OBJECTIVE
  To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP).
  
  
  BACKGROUND
  LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD.
  
  
  METHODS
  The authors evaluated the brains of 72 consecutive cases of pathologically confirmed PSP and 98 normal controls, ranging in age from 60 to 100 years, with immunohistochemistry for alpha-synuclein.
  
  
  RESULTS
  LB and Lewy neurites were found in 13 cases of PSP, with the most numerous LB and Lewy neurites in the basal forebrain and amygdala; most cases also had LB in the substantia nigra. The frequency of LB in the substantia nigra (12%) was comparable to the frequency of LB in controls (9%).
  
  
  CONCLUSIONS
  In contrast to increased frequency of LB in AD, there is no apparent interaction between LB and the tau pathology in PSP.
authors.affiliation: Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuboi
authors.forename: J E
authors.initials: JE
authors.lastname: Ahlskog
authors.forename: H
authors.initials: H
authors.lastname: Apaydin
authors.forename: J E
authors.initials: JE
authors.lastname: Parisi
authors.forename: D W
authors.initials: DW
authors.lastname: Dickson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000679:Amygdala / Q000473:pathology; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D008297:Male; D016548:Prosencephalon / Q000473:pathology; D013378:Substantia Nigra / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*