title: Palliative surgical debulking in malignant mesothelioma. Predictors of survival and symptom control.
abstract: OBJECTIVE
  Malignant mesothelioma (MM) typically presents at an advanced stage. In the UK surgical intervention has been mostly reserved for tissue diagnosis or chemical pleurodesis. However, the role of debulking surgery in symptom control has not been fully explored.
  
  
  METHODS
  In a prospective cohort study, 51 consecutive patients presenting with MM underwent palliative surgical debulking for symptomatic relief (all patients presented with dyspnoea, 39 also had pain and two had a co-existing pleural empyema). Patients with early disease who underwent extrapleural pneumonectomy were excluded. The treatment aims were pleural drainage, lung re-expansion, pleurodesis and pleural debulking for symptom control. If the lung re-expanded after drainage of the effusion a subtotal parietal pleurectomy was performed via Video Assisted Thoracic Surgery (VATS). If the lung remained entrapped, a parietal and visceral decortication using VATS or thoracotomy was performed. The changes in subjective dyspnoea and pain scores were recorded at 6 weeks and 3, 6 and 12 months after surgery. Prognostic factors were analyzed to determine their influence on survival and symptom control.
  
  
  RESULTS
  VATS pleurectomy was possible in 17 patients (34%), whilst decortication was required in the remainder (three by VATS and 31 by thoracotomy). Median postoperative stay was 7 days (range 2-17) with 30-day mortality of 7.8% (four of 51 patients). Morbidity included postoperative empyema in two patients (4%) and prolonged air-leak in five (9.8%). Overall significant symptomatic benefit was obtained up to 3 months after surgery but subsequently increasing mortality offset these benefits. Epithelial cell type and absence of weight loss prior to surgery were found to predict longer survival and successful symptom control.
  
  
  CONCLUSIONS
  Debulking surgery has a beneficial role in symptom control for unresectable MM. However, this surgery should be reserved for those patients who present with epithelial cell type and before significant loss of weight.
authors.affiliation: Department of Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
authors.forename: A E
authors.initials: AE
authors.lastname: Martin-Ucar
authors.forename: J G
authors.initials: JG
authors.lastname: Edwards
authors.forename: A
authors.initials: A
authors.lastname: Rengajaran
authors.forename: S
authors.initials: S
authors.lastname: Muller
authors.forename: D A
authors.initials: DA
authors.lastname: Waller
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007902:Length of Stay; D008175:Lung Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008654:Mesothelioma / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D008875:Middle Aged; D010166:Palliative Care; D010994:Pleura / Q000601:surgery; D011013:Pneumonectomy; D011379:Prognosis; D020775:Thoracic Surgery, Video-Assisted; D016896:Treatment Outcome