title: Minimally invasive application of botulinum toxin type A in nasal hypersecretion.
abstract: We report on the effect of the local application of botulinum toxin A on nasal hypersecretion in a female patient with intrinsic rhinitis. 20 units of botulinum toxin A (Botox) was inserted into each nostril using a small sponge in close contact with the lower and middle turbinates. The effect was scored by the patient and by rhinomanometry. Nasal hypersecretion diminished clearly 5 days after the treatment. The rhinomanometric flow increased 2 weeks after the application. No side effects occurred. We conclude that this minimal invasive method of local botulinum toxin application might be a very effective and safe option for the treatment of nasal hypersecretion of different etiologies.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Georg August University, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany. saskia.rohrbach@med.uni-goettingen.de
authors.forename: S
authors.initials: S
authors.lastname: Rohrbach
authors.forename: R
authors.initials: R
authors.lastname: Laskawi
mesh_terms: D000281:Administration, Intranasal; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009093:Mucus / Q000187:drug effects; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D012220:Rhinitis / Q000188:drug therapy*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A