Optimization of a solid-phase synthesis of a PNA monomer.
A new scheme for the synthesis of peptide nucleic acid (PNA) is described. First, a resin-bound amino acid is alkylated under Fukuyama-Mitsunobu conditions. A nucleobase is then incorporated via an acid fluoride. Subsequently, oligomerization may be achieved by deprotection, coupling of another amino acid, and repetition of the cycle. Each step of the submonomer synthesis has been optimized to provide essentially quantitative yield. [reaction: see text]
Viirre
R D
RD
Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada.
Hudson
R H
RH
D009682:Magnetic Resonance Spectroscopy; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*
D020135:Peptide Nucleic Acids