title: Aspergillus fumigatus cranial infection after accidental traumatism.
abstract: Described here is a case of Aspergillus fumigatus cranial infection secondary to accidental cranial traumatism that occurred in an immunocompetent patient and the questions that arose concerning treatment. No reports of post-traumatic cranial osteomyelitis caused by Aspergillus spp. and the ideal treatment to be followed have yet been described in the literature. In the present case, surgical debridement of the wound followed by treatment with 1 mg/kg/iv/day of amphotericin B for 21 days and then 200 mg/vo/12 h of itraconazole for 6 months obtained good results.
authors.affiliation: Infectious Diseases Service, University Hospital Virgen del Rocío, Seville, Spain. Luisfed@arrakis.es
authors.forename: M J
authors.initials: MJ
authors.lastname: Rodríguez-Hernández
authors.forename: M E
authors.initials: ME
authors.lastname: Jiménez-Mejías
authors.forename: J M
authors.initials: JM
authors.lastname: Montero
authors.forename: C
authors.initials: C
authors.lastname: Regordan
authors.forename: G
authors.initials: G
authors.lastname: Ferreras
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D001228:Aspergillosis / Q000175:diagnosis* / Q000628:therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000302:isolation & purification*; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015601:Injury Severity Score; D017964:Itraconazole / Q000008:administration & dosage*; D012886:Skull / Q000293:injuries*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: D017964:Itraconazole; D000666:Amphotericin B