title: Approximate distribution of dose among foetal organs for radioiodine uptake via placenta transfer.
abstract: Absorbed radiation doses to internal foetal organs were calculated according to the medical internal radiation dose (MIRD) technique in this study. Anthropomorphic phantoms of the pregnant female as in MIRDOSE3 enabled estimation of absorbed dose to the whole foetus at two stages of gestation. Some foetal organ self-doses could have been estimated by invoking simple spherical models for thyroid, liver, etc, but we investigated the use of the MIRDOSE3 new-born phantom as a surrogate for the stage 3 foetus, scaled to be compatible with total foetal body mean absorbed dose/cumulated activity. We illustrate the method for obtaining approximate dose distribution in the foetus near term following intake of 1 MBq of 123I, 124I, 125I or 131I as sodium iodide by the mother using in vivo biodistribution data examples from a good model of placenta transfer. Doses to the foetal thyroid of up to 1.85 Gy MBq(-1) were predicted from the 131I uptake data. Activity in the foetal thyroid was the largest contributor to absorbed dose in the foetal body, brain, heart and thymus. Average total doses to the whole foetus ranged from 0.16 to 1.2 mGy MBq(-1) for stages 1 and 3 of pregnancy using the MIRDOSE3 program, and were considerably higher than those predicted from the maternal contributions alone. Doses to the foetal thymus and stomach were similar, around 2-3 mGy MBq(-1). Some foetal organ doses from the radioiodides were ten times higher than to the corresponding organs of the mother, and up to 100 times higher to the thyroid. The fraction of activity uptakes in foetal organs were distributed similarly to the maternal ones.
authors.affiliation: Medical Physics Research Centre, Bristol Oncology Centre, UK. rkmillard_69@yahoo.co.uk
authors.forename: R K
authors.initials: RK
authors.lastname: Millard
authors.forename: M
authors.initials: M
authors.lastname: Saunders
authors.forename: A M
authors.initials: AM
authors.lastname: Palmer
authors.forename: A W
authors.initials: AW
authors.lastname: Preece
mesh_terms: D001921:Brain / Q000196:embryology* / Q000528:radiation effects; D019992:Databases as Topic; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D006321:Heart / Q000196:embryology* / Q000528:radiation effects; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange; D009928:Organ Specificity; D019047:Phantoms, Imaging; D010920:Placenta / Q000502:physiology; D011247:Pregnancy; D011874:Radiometry; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000009:adverse effects / Q000493:pharmacokinetics*; D013950:Thymus Gland / Q000196:embryology* / Q000528:radiation effects; D013961:Thyroid Gland / Q000528:radiation effects; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals