title: Contribution of interleukin-1 to Th1- and Th2-dependent variants of chronic graft-versus-host reaction.
abstract: Semiallogenic transfer of lymphoid cells from parental DBA/2 strain to (C57Bl/6xDBA/2)F1 hybrids induces two variants of chronic graft-versus-host reaction with predominant activation of donor Th1 or Th2 cells [2] in genetically homologous recipients: first, severe inhibition of the humoral immune response, or second, autoimmune disease (lupus nephritis) against the background of suppressed cell and humoral immunity. These variants of chronic graft-versus-host reaction are characterized by different changes in interleukin-1 level.
authors.affiliation: Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
authors.forename: V A
authors.initials: VA
authors.lastname: Kozlov
authors.forename: I V
authors.initials: IV
authors.lastname: Safronova
authors.forename: O T
authors.initials: OT
authors.lastname: Kudaeva
authors.forename: O P
authors.initials: OP
authors.lastname: Kolesnikova
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000276:immunology; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology; D006087:Graft vs Host Reaction / Q000276:immunology*; D007375:Interleukin-1 / Q000235:genetics / Q000502:physiology*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D018183:Transplantation Chimera
chemical_list: D007375:Interleukin-1