General pharmacological properties of Sho-seiryu-to (TJ-19) extracts.
The general pharmacological properties of TJ-19 extracts were orally investigated in various experimental animals. TJ-19 extracts showed no effect on general behavior and on central nervous system such as spontaneous locomotor activity, proconvulsant and anti-convulsant responses, analgesic activity, body temperature and hexobarbital sleeping time at all doses of 0.5, 1 and 2 g/kg in mice. Further, TJ-19 extracts showed no effect on contractile responses of isolated guinea pig ileum induced by acetylcholine, histamine and BaCl2 at concentrations of 10(-6), 10(-5), and 10(-4) g/ml. TJ-19 extracts, however, increased the respiratory rate, heart rate, blood pressure, systolic pressure, diastolic pressure, and decreased the blood flow in dogs at all doses of 0.5, 1 and 2 g/kg via duodenal administration. Further, TJ-19 extracts decreased the interval of PR and QT of EKG parameters in dogs at doses of 1 and 2 g/kg. TJ-19 extracts increased the intestinal transport of charcoal meal in rats at doses of 1 and 2 g/kg. TJ-19 increased the urinary Na+ excretion at all doses of 0.5, 1, and 2 g/kg, and increased the urinary K+ and Cl- excretion at 1 and 2 g/kg, although it showed no effect on urine volume output in rats. These data suggest that TJ-19 stimulates the sympathetic nervous system function at a pharmacological dose of under 0.5 g/kg, and has possibility to increase the intestinal peristalsis and urinary electrolyte excretion at higher doses.
Amagaya
S
S
Central Research Laboratories, Tsumura & Co., Inashiki-gun, Ibaraki, Japan. amagaya_sakae@mail.tsumura.co.jp
Iizuka
A
A
Makino
B
B
Kubo
M
M
Komatsu
Y
Y
Cheng
F C
FC
Ruo
T I
TI
Itoh
T
T
Terasawa
K
K
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001259:Ataxia / Q000188:drug therapy / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007677:Kidney Function Tests; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D023421:Models, Animal; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D020318:Rats, Long-Evans; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; C090832:sho-seiryu-to