[Multivariate logistic regression analysis on the risk factors of type 2 diabetes mellitus].
OBJECTIVE
To explore the relationship between multivariate factors and type 2 diabetes mellitus.


METHODS
Polymorphisms of microsatellite markers in uncoupling protein 3 (UCP3) gene, hormone-sensitive lipase (HSL) gene and protein tyrosine phosphatase-1B (PTP-1B) gene were tested in 106 patients with type 2 diabetes and 102 control subjects by performing polymerase chain reaction (PCR), polyacrylamide gel electrophoresis and silver staining. Multivariate logistic regression analysis was performed by all factors.


RESULTS
Through univariate analysis, type 2 diabetes had significantly positive associations with age, systolic blood pressure (SBP), fasting insulin (FINS) level, cholesterol, triglyceride, low-density lipoprotein, apolipoprotein B (ApoB), alpha lipoprotein, UCP3 gene allele 6, UCP3 gene allele 7, HSL gene allele 9, and negative associations with UCP3 gene allele 1 and 3, HSL gene allele 5, high-density lipoprotein. The results of multivariate logistic analysis showed that UCP3 gene allele 6, UCP3 gene allele 7, SBP, ApoB, alpha lipoprotein were still positively related to type 2 diabetes, while HSL gene allele 5, high-density lipoprotein were still negatively related to type 2 diabetes.


CONCLUSIONS
Our data showed that UCP3 gene allele 6, UCP3 gene allele 7, SBP, abnormity of plasma ApoB and alpha lipoprotein might play a role in the development of type 2 diabetes. HSL gene allele 5, high-density lipoprotein might play some protective role in the development of type 2 diabetes.
Lu
Y
Y
Department of Endocriology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
Miao
H
H
Wang
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H
D001794:Blood Pressure; D002352:Carrier Proteins / Q000235:genetics; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007473:Ion Channels; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins; D015999:Multivariate Analysis; D012044:Regression Analysis; D012307:Risk Factors; D002787:Sterol Esterase / Q000235:genetics; D000071247:Uncoupling Protein 3
D002352:Carrier Proteins; D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604392:UCP3 protein, human; D000071247:Uncoupling Protein 3; D002787:Sterol Esterase