title: Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men.
abstract: The effectiveness of a nutritional supplement designed to enhance serum testosterone concentrations and prevent the formation of dihydrotestosterone and estrogens from the ingested androgens was investigated in healthy 30- to 59-year old men. Subjects were randomly assigned to consume DION (300 mg androstenedione, 150 mg dehydroepiandrosterone, 540 mg saw palmetto, 300 mg indole-3-carbinol, 625 mg chrysin, and 750 mg Tribulus terrestris per day; n = 28) or placebo (n = 27) for 28 days. Serum free testosterone, total testosterone, androstenedione, dihydrotestosterone, estradiol, prostate-specific antigen (PSA), and lipid concentrations were measured before and throughout the 4-week supplementation period. Serum concentrations of total testosterone and PSA were unchanged by supplementation. DION increased (p < 0.05) serum androstenedione (342%), free testosterone (38%), dihydrotestosterone (71%), and estradiol (103%) concentrations. Serum HDL-C concentrations were reduced by 5.0 mg/dL in DION (p < 0.05). Increases in serum free testosterone (r2 = 0.01), androstenedione (r2 = 0.01), dihydrotestosterone (r2 = 0.03), or estradiol (r2 = 0.07) concentrations in DION were not related to age. While the ingestion of androstenedione combined with herbal products increased serum free testosterone concentrations in older men, these herbal products did not prevent the conversion of ingested androstenedione to estradiol and dihydrotestosterone.
authors.affiliation: Exercise Biochemistry Laboratory, Department of Health and Human Performance, Iowa State University, Ames, IA, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Brown
authors.forename: M D
authors.initials: MD
authors.lastname: Vukovich
authors.forename: E R
authors.initials: ER
authors.lastname: Martini
authors.forename: M L
authors.initials: ML
authors.lastname: Kohut
authors.forename: W D
authors.initials: WD
authors.lastname: Franke
authors.forename: D A
authors.initials: DA
authors.lastname: Jackson
authors.forename: D S
authors.initials: DS
authors.lastname: King
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D000735:Androstenedione / Q000627:therapeutic use*; D003687:Dehydroepiandrosterone / Q000627:therapeutic use*; D019587:Dietary Supplements; D004311:Double-Blind Method; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood
chemical_list: D000276:Adjuvants, Immunologic; D012739:Gonadal Steroid Hormones; D028321:Plant Preparations; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone