Outbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Neisseria gonorrhoeae in Japan.
We have previously reported that the Neisseria gonorrhoeae isolates from clinical failure cases treated with cefdinir and aztreonam, beta-lactams exhibited high MICs. These resistant isolates were clearly separated from the isolates exhibiting a low level of resistance to beta-lactams as shown by the MIC distribution of cefozopran. Restriction fragment length polymorphism DNA typing revealed that the outbreak of cefozopran-resistant isolates in Kitakyushu, Japan, occurred as a result of clonal spread.
Muratani
T
T
Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan. muratani@med.uoeh-u.ac.jp
Akasaka
S
S
Kobayashi
T
T
Yamada
Y
Y
Inatomi
H
H
Takahashi
K
K
Matsumoto
T
T
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001398:Aztreonam / Q000494:pharmacology / Q000627:therapeutic use; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000235:genetics; D004196:Disease Outbreaks; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008997:Monobactams / Q000627:therapeutic use; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics; D010406:Penicillins / Q000494:pharmacology / Q000627:therapeutic use; D012150:Polymorphism, Restriction Fragment Length; D000097586:Cefozopran
D000900:Anti-Bacterial Agents; D001398:Aztreonam; D002511:Cephalosporins; D004269:DNA, Bacterial; D008997:Monobactams; D010406:Penicillins; D000097586:Cefozopran