title: Cryofibrinogenemia in a patient with B-cell lymphoma.
abstract: Cryofibrinogenemia is an uncommon cause of intravascular coagulation necrosis of the skin and occurs as a result of vascular occlusion from cryoproteins, which reversibly precipitate in cold temperatures. The disease is associated with various conditions, most commonly neoplastic and thromboembolic diseases, and produces cutaneous manifestations such as purpura, ecchymoses, gangrene, and ulcerations. Diagnosis is based on clinical cutaneous manifestations, histopathology, and the laboratory detection of cryofibrinogen precipitation. Treatment is based upon resolution of the underlying disease process or condition, although some interventions have been reported to have therapeutic efficacy. We discuss the presentation, diagnosis, and treatment of a case of cryofibrinogenemia in a patient with underlying B-cell lymphoma.
authors.affiliation: Department of Dermatology, University of Texas Health Science Center, Houston, TX, USA.
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: N
authors.initials: N
authors.lastname: Apisarnthanarax
authors.forename: R E
authors.initials: RE
authors.lastname: Jordon
authors.forename: M
authors.initials: M
authors.lastname: Duvic
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D003449:Cryoglobulinemia / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D003450:Cryoglobulins / Q000009:adverse effects; D005260:Female; D015241:Fibrinogens, Abnormal / Q000009:adverse effects; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D009336:Necrosis; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D003450:Cryoglobulins; D015241:Fibrinogens, Abnormal; C041874:cryofibrinogen; D008775:Methylprednisolone