[Effects of simulated weightlessness on T cell subpopulations and activity of IL-2 and IL-6 in mice].
OBJECTIVE
To observe the effects of simulated weightlessness on the immunogenic activities in mice.


METHODS
T cell subpopulations and the activity of IL-2 and IL-6 were observed in mice after exposure to head-down (-30 degrees) tail suspension for 3 d and 7 d.


RESULTS
The activity of IL-2 and IL-6 in mice showed no change after simulated weightlessness for 3 d compared with the control group. But after simulated weightlessness for 7 d, CD3+ and CD4+ were markedly reduced (both P< 0.01) and CD8+ and CD4+/CD8+ also tended to decrease; the activity of IL-2 was significantly decreased, while the activity of IL-6 tended to increase.


CONCLUSIONS
Simulated weightlessness for 7 d had significant effects on T cell subpopulations and the activity of certain cytokines in mice.
Wen
X L
XL
Institute of Space Medico-Engineering, Beijing, China.
Yang
G H
GH
Wang
T
T
Hu
P
P
D000818:Animals; D017252:CD3 Complex; D015704:CD4 Antigens; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens; D019417:Hindlimb Suspension; D007376:Interleukin-2 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D018474:Weightlessness Simulation
D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D007376:Interleukin-2; D015850:Interleukin-6