title: Werner's syndrome (adult progeria): an affected mother and son presenting with resistant psychosis.
abstract: Age-related psychotic conditions may be studied by focusing on the unique group of progeroid syndromes. This report will focus on Werner's syndrome, one of the better defined and studied progeroid syndromes. We applied clinical and histophysiological evaluations to two patients, a mother and son, suffering from Werner's syndrome. Both patients presented with resistant psychosis and evidence of impaired cellular repair mechanisms. Psychiatric morbidity in Werner's syndrome is rarely reported. This syndrome can serve as a possible model for aging-associated development of psychosis.
authors.affiliation: Abarbanel Mental Health Center, Bat-Yam, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Barak
authors.forename: P
authors.initials: P
authors.lastname: Sirota
authors.forename: R
authors.initials: R
authors.lastname: Kimhi
authors.forename: H
authors.initials: H
authors.lastname: Slor
mesh_terms: D000328:Adult; D000368:Aged; D004247:DNA / Q000032:analysis; D004260:DNA Repair / Q000235:genetics; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008297:Male; D009034:Mother-Child Relations; D011618:Psychotic Disorders / Q000150:complications* / Q000523:psychology; D014057:Tomography, X-Ray Computed; D014898:Werner Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics
chemical_list: D004247:DNA