title: NAD(P)-dependent aldehyde dehydrogenases induced during growth of Ralstonia eutropha strain Bo on tetrahydrofurfuryl alcohol.
abstract: Different aldehyde dehydrogenases (AlDHs) were formed during growth of Ralstonia eutropha Bo on tetrahydrofurfuryl alcohol (THFA). One of these enzymes, AlDH 4, was purified and characterized as a homodimer containing no prosthetic groups, showing a strong substrate inhibition, and having an N-terminal sequence similar to those of various NAD(P)-dependent AlDHs. The conversion rate of THFA by the quinohemoprotein THFA dehydrogenase was increased by AlDH 4.
authors.affiliation: Institut für Mikrobiologie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Schräder
authors.forename: G
authors.initials: G
authors.lastname: Zarnt
authors.forename: J R
authors.initials: JR
authors.lastname: Andreesen
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000096:biosynthesis*; D000445:Aldehyde Oxidoreductases / Q000096:biosynthesis*; D001426:Bacterial Proteins; D001673:Biodegradation, Environmental; D020118:Cupriavidus necator / Q000201:enzymology*; D004790:Enzyme Induction; D005663:Furans / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D009243:NAD; D009249:NADP; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D005663:Furans; D015262:Xenobiotics; D009243:NAD; D009249:NADP; D000429:Alcohol Oxidoreductases; C442136:tetrahydrofurfuryl alcohol dehydrogenase; D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase; C018699:aldehyde dehydrogenase (NAD(P)+); C018675:tetrahydrofurfuryl alcohol