title: Blastic mantle cell lymphoma associated with Burkitt-type translocation and hypodiploidy.
abstract: Two elderly men with stage IV mantle cell lymphoma (MCL) rapidly developed a leukaemic phase with unusually high blast counts that proved fatal. One lymph node biopsy showed diffuse MCL, the other blastic morphology. In addition to t(11;14), there were t(8;14) and t(1;19) in case 1 and dup(8)(q24q13) in case 2. Fluorescence in situ hybridization revealed genomic fusion of IgH/MYC genes in case 1 and an extra copy of C-MYC gene in case 2. The genomic alteration of C-MYC oncogene is probably implicated in the blastic transformation and aggressive behaviour of the disease.
authors.affiliation: Division of Hematology Oncology, Department of Medicine, Wayne State University/Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.
authors.forename: U N
authors.initials: UN
authors.lastname: Vaishampayan
authors.forename: A N
authors.initials: AN
authors.lastname: Mohamed
authors.forename: M C
authors.initials: MC
authors.lastname: Dugan
authors.forename: R E
authors.initials: RE
authors.lastname: Bloom
authors.forename: M
authors.initials: M
authors.lastname: Palutke
mesh_terms: D000368:Aged; D002051:Burkitt Lymphoma / Q000235:genetics; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D008297:Male; D011003:Ploidies; D014178:Translocation, Genetic