Biochemical and molecular mechanisms of drug resistance in parasites.
Drug resistance is complicating the treatment of parasitic diseases. We review here the basic mechanisms of parasite resistance in malaria, sleeping sickness, leishmaniasis and common helminthiases. Parasites resort to multiple biochemical means to achieve resistance and we have begun to isolate and characterize the genes/proteins implicated in resistance. Understanding drug resistance is essential for the control of parasitic diseases.
Ouellette
M
M
Centre de Recherche en Infectiologie du Centre de Recherche du CHUL and Département de Microbiologie, Faculté de Médecine, Université Laval, Québec, Canada. marc.coullette@crchul.ulaval.ca
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D006373:Helminthiasis / Q000188:drug therapy; D006801:Humans; D007896:Leishmaniasis / Q000188:drug therapy; D008288:Malaria / Q000188:drug therapy; D010272:Parasitic Diseases / Q000188:drug therapy*; D016896:Treatment Outcome; D014353:Trypanosomiasis, African / Q000188:drug therapy
D000871:Anthelmintics; D000981:Antiprotozoal Agents