title: Postischemic mechanoenergetic inefficiency is related to contractile dysfunction and not altered metabolism.
abstract: Mechanoenergetic inefficiency in postischemic nonnecrotic myocardium may partly be explained by an increased fatty acid (FA) oxidation rate. In the present study, left ventricular (LV) postischemic energy transfer was characterized in 10 intact anesthetized pigs. The LV was stunned by 11 brief left main coronary artery occlusions/reperfusions (20-min accumulated ischemia). Seven pigs served as time controls. The relationship between myocardial oxygen consumption (MVO(2)) and LV pressure-volume area (PVA) was assessed. [(14)C]glucose and [(3)H]oleate markers were used to discriminate between glucose and FA consumption. In stunned hearts, severe postischemic dysfunction was observed, and contractile efficiency was reduced (increased MVO(2)-PVA slope, P = 0.001). Unloaded (nonmechanical) MVO(2) was not affected by ischemia. We observed only a small transient increase in FA preference and conclude that the contribution from increased FA utilization to postischemic mechanoenergetic inefficiency is insignificant. Disrupted postischemic chemical-to-mechanical energy transfer in vivo is, therefore, related to inefficient energy utilization in the contractile apparatus.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University Hospital Tromsø, N-9038 Tromsø, Norway. christian.korvald@rito.no
authors.forename: C
authors.initials: C
authors.lastname: Korvald
authors.forename: O P
authors.initials: OP
authors.lastname: Elvenes
authors.forename: E
authors.initials: E
authors.lastname: Aghajani
authors.forename: E S
authors.initials: ES
authors.lastname: Myhre
authors.forename: T
authors.initials: T
authors.lastname: Myrmel
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002250:Carbon Radioisotopes; D004734:Energy Metabolism / Q000502:physiology*; D005227:Fatty Acids / Q000097:blood; D005947:Glucose / Q000493:pharmacokinetics; D019344:Lactic Acid / Q000097:blood; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology; D017682:Myocardial Stunning / Q000378:metabolism* / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D019301:Oleic Acid / Q000493:pharmacokinetics; D010101:Oxygen Consumption / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D013552:Swine; D014316:Tritium; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D001786:Blood Glucose; D002250:Carbon Radioisotopes; D005227:Fatty Acids; D014316:Tritium; D019301:Oleic Acid; D019344:Lactic Acid; D005947:Glucose