title: [Anasarcous mechanism induced by hypercapnia in rats].
abstract: OBJECTIVE
  To study anasarcous pathogenesis during hypercapnia.
  
  
  METHODS
  The mixed gases of highly concentrated carbon dioxide (8% CO2, 21% O2, 71% N2) were given to Wistar rats 7 hours a day for four weeks. The various indexes were comparatively observed between control group and hypercapnia group.
  
  
  RESULTS
  Pulmonary arterial pressure (mPAP) in control group was (1.94 +/- 0.28) kPa and PaCO2 (4.6 +/- 0.9) kPa. T1/2 of 125I-BSA in the blood was (238 +/- 30) min, plasma lipid peroxide (LPO) level (3.08 +/- 0.69) nmol/ml, erythrocytic superoxide dismutase (SOD) activity (1,042 +/- 135) CU/g Hb. Water content was (76.2 +/- 1.0)% in lung and (74.1 +/- 2.8)% in muscular tissues. mPAP in hypercapnia group was (2.0 +/- 0.4) kPa, PaCO2 (7.4 +/- 0.4) kPa, T1/2 (150 +/- 23) min, LPO (8.8 +/- 2.0) nmol/ml, SOD (682 +/- 341) U/g Hb1 and water content was (78.8 +/- 1.8)% in lung and (76.04 +/- 1.07)% in muscular tissues. No significant differences were found in mPAP (P > 0.05). There were significant differences in PaCO2 (P < 0.01), T1/2 (P < 0.01), LPO (P < 0.001), SOD (P < 0.01), water content in lung (P < 0.01), and water content in muscular tissues (P < 0.05).
  
  
  CONCLUSIONS
  Rat hypercapnic model can be reproduced with 8% CO2 mixed gases. Systemic water and natrium retention (edema) might occur in the model. Microvascular endothelial cell damage and its highly increased permeability induced by lipid peroxidation is the direct cause of edema. The pulmonary cause per se can produce anasarca.
authors.affiliation: Department of Respiratory Disease, Beijing Red Cross Chaoyang Hospital, Beijing 100020.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Pang
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D004487:Edema / Q000209:etiology* / Q000503:physiopathology; D006935:Hypercapnia / Q000150:complications* / Q000503:physiopathology; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar