title: Linkage of body mass index to chromosome 20 in Utah pedigrees.
abstract: Several linkage studies have hinted at the existence of an obesity predisposition locus on chromosome 20, but none of these studies has produced conclusive results. Therefore, we analyzed 48 genetic markers on chromosome 20 for linkage to severe obesity (BMI> or =35) in 103 extended Utah pedigrees (1,711 individuals), all of which had strong aggregation of severe obesity. A simple dominant model produced a maximum multipoint heterogeneity LOD score of 3.5 at D20S438 (55.1 cM). Two additional analyses were performed. First, a one-gene, two-mutation model (with one dominant mutation and one recessive mutation) increased the LOD score to 4.2. Second, a two-locus model (with one locus dominant and one recessive) generated a multipoint LOD score of 4.9. We conclude that one or more severe obesity predisposing genes lie within an interval of approx. 10 cM on chromosome 20. This study generated significant LOD scores which confirm suggestive linkage reports from previous studies. In addition, our analyses suggest that the predisposing gene(s) is localized very near the chromosome 20 centromere.
authors.affiliation: Cardiovascular Genetics, University of Utah, 410 Chipeta Way RM 167, Salt Lake City, UT 84108, USA. steve@ucvg.med.utah.edu
authors.forename: S C
authors.initials: SC
authors.lastname: Hunt
authors.forename: V
authors.initials: V
authors.lastname: Abkevich
authors.forename: C H
authors.initials: CH
authors.lastname: Hensel
authors.forename: A
authors.initials: A
authors.lastname: Gutin
authors.forename: C D
authors.initials: CD
authors.lastname: Neff
authors.forename: D L
authors.initials: DL
authors.lastname: Russell
authors.forename: T
authors.initials: T
authors.lastname: Tran
authors.forename: X
authors.initials: X
authors.lastname: Hong
authors.forename: S
authors.initials: S
authors.lastname: Jammulapati
authors.forename: R
authors.initials: R
authors.lastname: Riley
authors.forename: J
authors.initials: J
authors.lastname: Weaver-Feldhaus
authors.forename: T
authors.initials: T
authors.lastname: Macalma
authors.forename: M M
authors.initials: MM
authors.lastname: Richards
authors.forename: R
authors.initials: R
authors.lastname: Gress
authors.forename: M
authors.initials: M
authors.lastname: Francis
authors.forename: A
authors.initials: A
authors.lastname: Thomas
authors.forename: G C
authors.initials: GC
authors.lastname: Frech
authors.forename: T D
authors.initials: TD
authors.lastname: Adams
authors.forename: D
authors.initials: D
authors.lastname: Shattuck
authors.forename: S
authors.initials: S
authors.lastname: Stone
mesh_terms: D015992:Body Mass Index; D002503:Centromere / Q000235:genetics; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D009765:Obesity / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D014589:Utah
chemical_list: D005819:Genetic Markers