title: Nonpharmacologic thromboembolic prophylaxis in total knee arthroplasty.
abstract: Deep venous thrombosis is the most common complication in patients having elective total knee replacement. Pneumatic compression devices play an important role in the prophylaxis of deep venous thrombosis and effectively decrease the risk of distal deep venous thrombosis. The combination therapy with pharmacologic agents has the benefit of decreasing the rate of proximal deep venous thrombosis and therefore is recommended. In the absence of clinical data, recent in vivo flow studies suggest that calf or combined foot and calf compression are superior to foot compression alone. Epidural anesthesia in comparison with general anesthesia decreases the incidence of thromboembolic disease after total knee arthroplasty. Although hypotensive anesthesia and intraoperative heparin have been proven to substantially lower the incidence of deep venous thrombosis after total hip arthroplasty, the current literature does not support its application during the implantation of a total knee replacement. Pneumatic compression devices are an important part of deep venous thrombosis prophylaxis especially in the early postoperative period considering that pharmacologic anticoagulation is contraindicated in the first 12 hours after spinal anesthesia and in the presence of an epidural line.
authors.affiliation: Hospital for Special Surgery, New York, NY 10021, USA.
authors.forename: F
authors.initials: F
authors.lastname: Bottner
authors.forename: T P
authors.initials: TP
authors.lastname: Sculco
mesh_terms: D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D006801:Humans; D007866:Leg / Q000098:blood supply; D011312:Pressure; D012039:Regional Blood Flow; D020246:Venous Thrombosis / Q000517:prevention & control*