title: Characteristics of oral and paraoral malignant lymphoma: a population-based review of 361 cases.
abstract: BACKGROUND
  Lymphoma is the second most common neoplasm of the head and neck; almost 50% of all lymphomas occur in this region. Waldeyer's ring is the most common site of lymphomas involving the oral region. The purpose of this study was to review the characteristics of a large series of malignant lymphoma of the oral region.
  
  
  METHODS
  Three hundred sixty-one consecutive cases of malignant lymphoma of the oral region were identified in the Tumor Registry between 1969 and 1998.
  
  
  RESULTS
  The 361 cases (200 males and 161 females) of malignant lymphoma of the oral region accounted for 3.5% of all oral malignancies. The mean age was 62.5 years and the most prevalent site of involvement was the tonsil (32.7%), followed by the parotid gland (16.1%). Sixty-five percent of the lesions were diagnosed as large-cell (38%) or small-cell (27%) lymphoma. One quarter of the patients died of the disease in a mean of 2.78 years after diagnosis. Of a total 26 patients who died from other causes, 12 died because of other cancers, including 7 (27%) with leukemia and 5 (19%) with oral carcinoma. The prognosis is based, at least partially, on the histologic grading (low, intermediate, or high) and the anatomic stage of the disease. Localized low-grade lymphomas have a more favorable prognosis compared with those that are disseminated and/or have high-grade cellular changes.
  
  
  CONCLUSIONS
  Lymphoma is the second most common malignant oral disease. Thorough head and neck and oral examination is necessary to identify lesions that may represent lymphoma.
authors.affiliation: Department of Dentistry, British Columbia Cancer Agency, Vancouver, Canada. jepstein@bccancer.bc.ca
authors.forename: J B
authors.initials: JB
authors.lastname: Epstein
authors.forename: J D
authors.initials: JD
authors.lastname: Epstein
authors.forename: N D
authors.initials: ND
authors.lastname: Le
authors.forename: M
authors.initials: M
authors.lastname: Gorsky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001955:British Columbia / Q000453:epidemiology; D002277:Carcinoma / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D007938:Leukemia / Q000453:epidemiology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology; D008223:Lymphoma / Q000453:epidemiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology*; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000453:epidemiology; D010307:Parotid Neoplasms / Q000453:epidemiology; D011159:Population Surveillance; D011379:Prognosis; D012042:Registries; D015996:Survival Rate; D014067:Tonsillar Neoplasms / Q000453:epidemiology