title: Autoimmune vesicles on the face and neck. A variant of Brunsting-Perry type localized bullous pemphigoid?
abstract: We report a case of blistering disease presenting a unique distribution of vesiculobullous lesions on the face and neck which is similar to Brunsting-Perry type of localized bullous pemphigoid (BP). Histopathology of a lesional skin biopsy demonstrated a subepidermal blister. Direct immunofluorescence demonstrated a strong linear deposition of IgG and IgA to the basement membrane zone, and a faint staining for C3. However, circulating antibodies were not detected by indirect immunofluorescence and immunoblotting. And the patient did not develop atrophic scars and was a relatively young woman. This case might be a variant of Brunsting-Perry type of localized BP or localized epidermolysis bullosa acquisita, presenting the clinical heterogeneity of subepidermal blistering diseases.
authors.affiliation: Department of Dermatology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. ysugita@med.yokohama-cu.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Sugita
authors.forename: N
authors.initials: N
authors.lastname: Inomata
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Yomoda
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Z
authors.initials: Z
authors.lastname: Ikezawa
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy / Q000379:methods; D005148:Facial Dermatoses / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique / Q000379:methods; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008911:Minocycline / Q000627:therapeutic use; D009333:Neck; D009536:Niacinamide / Q000627:therapeutic use; D009539:Nicotinic Acids / Q000627:therapeutic use; D010391:Pemphigoid, Bullous / Q000188:drug therapy / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D009539:Nicotinic Acids; D009536:Niacinamide; D011239:Prednisolone; D008911:Minocycline