title: [Craving for alcohol and prevention of relapse].
abstract: The long term course of alcohol dependence often includes one or several relapses, which can be divided into low (< 5 standard drinks = lapse, slip) and high intake of alcohol with loss of control (relapse). The biological etiology of relapse is derived from different phenomena such as alcohol craving, psychosocial reasons, development of withdrawal symptoms, different primary psychiatric diseases and "addiction memory". Moreover, the metabolism of alcohol itself substantially contributes to alcohol dependence. For about 100 years different definitions for subgroups of alcohol dependence have been described, of which the Lesch typology is internationally acknowledged, especially for medical treatment. This typology differentiates between four types of alcohol dependent patients in which prevention and treatment of relapse should be specific to the primary psychiatric disease of the patient and to alcohol related disabilities. The aim is a long term improvement of sobriety rates of alcohol dependent patients as well as quality of life and life expectancy.
authors.affiliation: Universitätsklinik für Psychiatrie, Wien, Osterreich. Otto.M.Lesch@akh-wien.ac.at
authors.forename: I
authors.initials: I
authors.lastname: Hertling
authors.forename: K
authors.initials: K
authors.lastname: Ramskogler
authors.forename: A
authors.initials: A
authors.lastname: Riegler
authors.forename: H
authors.initials: H
authors.lastname: Walter
authors.forename: R
authors.initials: R
authors.lastname: Mader
authors.forename: O M
authors.initials: OM
authors.lastname: Lesch
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000188:drug therapy / Q000517:prevention & control / Q000523:psychology / Q000628:therapy; D000818:Animals; D001348:Aversive Therapy; D002986:Clinical Trials as Topic; D006801:Humans; D011379:Prognosis; D051381:Rats; D012008:Recurrence; D013997:Time Factors