[Clinical study on the changes of growth hormone/insulin-like growth factor-I axis in patient with obstructive jaundice].
OBJECTIVE
To explore the changes and clinical significance of growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis in patient with obstructive jaundice (OJ).


METHODS
The serum GH, GH binding protein (GHBP), IGF-I, endotoxin, prealbumin, and liver function of 60 male in- patients with OJ were investigated 1 day before operation and 1, 3, and 7 days after the operation. Forty male patients with simple gallbladder stone who were hospitalized during the same period as the 60 above mentioned patients, were chosen as controls.


RESULTS
The levels of GH, GHBP and IGF-I in patients with obstructive jaundice were significantly lower (7.4 micrograms/L +/- 3.6 micrograms/L, 9.1 +/- 2.3 B/T* 100, and 49.8 mg/L +/- 6.6 mg/L respectively) than those in control group(13.9 micrograms/L +/- 5.7 micrograms/L, 13.3 +/- 1.6 B/T* 100, and 61.4 mg/L +/- 6.5 mg/L respectively, P < 0.01) and were correlated closely with the levels of bilirubin, prealbumin and endotoxin (P < 0.01).


CONCLUSIONS
There is an obvious downregulation of GH-IGF-I axis in patients with OJ probably because of the expression inhibition resulting from dystrophy and endoxemia. It may be one of the important factors mediating the pathophysiological changes in OJ.
An
Y
Y
Hepatobiliary Surgery Center of PLA, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Bie
P
P
Liu
B
B
D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000378:metabolism*; D004731:Endotoxins / Q000097:blood; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000032:analysis; D011986:Receptors, Somatotropin / Q000378:metabolism
D004731:Endotoxins; D018970:Insulin-Like Growth Factor Binding Protein 1; D011228:Prealbumin; D011986:Receptors, Somatotropin; D019382:Human Growth Hormone