[Mepartricine and prostatitis. Clinical experience and rationale for use].
BACKGROUND
The purpose of this study was to report our experience on the use of Mepartricine in the treatment of chronic and sub-acute prostatitis and to analyse, on the basis of the literature, the role of estrogens, the target of Mepartricine in the development and maintenance of prostatic inflammatory reactions.


METHODS
In a retrospective study the data of 110 patients who presented with lower urinary tract symptoms suggestive of prostatitis, from January 1994 to February 1999 have been evaluated: 65 of this patients had an abacterial prostatitis, and 45 a bacterial prostatitis. The Mearers-Stamey test was used to localize inflammation and pathogens to prostate. The clinical symptoms presented were essentially pelvic and perineal pain and irritative and obstructive voiding symptoms. The treatment was based on antibiotic therapy indicated by the sensitivity to antibiotic assay. In abacterial prostatitis, in cases of Chlamidia, Mycoplasma and Ureaplasma positivity, the treatment was based on macrolides and tetracycline use. All the patients received Mepartricine by oral supply, 1 daily tablet (40 mg) for 60 days.


RESULTS
After two months of treatment remarkable improvements in symptoms were obtained despite the persistent bacteriological positivity in the prostatic secretion in 68% of cases. Therefore antinflammatory antiedemic and decongestant effects of Mepartricine on prostatic inflammation, are observed.


CONCLUSIONS
The data of the literature show data estrogens modulate inflammatory reactions: it is possible that their decrease can produce, at prostatic level, antinflammatory effects improving urethro-prostatic bladder functions. Personal experience seems to confirm this supposition and so we think that Mepartri-cine can be considered and excellent coadjuvant in the treatment of prostate inflammation, independent of etiology.
Saita
A
A
Divisione Clinicizzata di Nefrologia Chirurgica-Urologia, Università degli Studi, Catania, Italy.
Morgia
G
G
Branchina
A
A
Giammusso
B
B
Iurato
C
C
Malacasa
E
E
Motta
M
M
D000328:Adult; D006801:Humans; D008297:Male; D008613:Mepartricin / Q000627:therapeutic use*; D008875:Middle Aged; D011472:Prostatitis / Q000188:drug therapy*; D012189:Retrospective Studies
D008613:Mepartricin