Diversity of gene expression in adenocarcinoma of the lung.
The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.
Garber
M E
ME
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Troyanskaya
O G
OG
Schluens
K
K
Petersen
S
S
Thaesler
Z
Z
Pacyna-Gengelbach
M
M
van de Rijn
M
M
Rosen
G D
GD
Perou
C M
CM
Whyte
R I
RI
Altman
R B
RB
Brown
P O
PO
Botstein
D
D
Petersen
I
I
D000230:Adenocarcinoma / Q000145:classification / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018287:Carcinoma, Large Cell / Q000145:classification / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000145:classification / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000235:genetics; D015870:Gene Expression; D020869:Gene Expression Profiling; D014644:Genetic Variation; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate / Q000639:trends