title: Unmasking of childhood hypothyroidism by disseminated xanthomas.
abstract: Secondary hyperlipidemia is a common laboratory finding in children with nephrotic syndrome, diabetes mellitus, and hypothyroidism. However, clinical signs of hyperlipidemia are extremely rare in childhood. We report on an 11-year-old girl who presented with a disseminated yellow papulomatous rash on the lower limbs and yellow skin creases on the palms of her hands. Blood tests yielded an opaque serum with a triglyceride concentration of 820 mg/dL and cholesterol of 1050 mg/dL. Skin biopsy of one of the papules confirmed the diagnosis of xanthomas. Additional examinations revealed clinical (weight gain, diminished growth rate) and biochemical primary hypothyroidism (free T4: 0.4 ng/L [normal 8-22 ng/L]; thyroid-stimulating hormone: >200 mU/L) as a consequence of Hashimoto thyroiditis (thyroid peroxidase and thyroglobulin: 4400 U/mL and >2000 U/mL, respectively; normal <60 U/mL). The patient was started on L-thyroxine, which led to a gradual decline of cholesterol and triglycerides to normal concentrations and a complete remission from the xanthomatous rash. For the first time, this case depicts disseminated xanthomas of the skin as the presenting complaint of severe hypothyroidism. hyperlipidemia, hypothyroidism, xanthoma.
authors.affiliation: Universitätsklinik für Kinder und Jugendliche, Erlangen, Erlagen, Germany. joergwdoetsch@yahoo.com
authors.forename: J
authors.initials: J
authors.lastname: Dötsch
authors.forename: K
authors.initials: K
authors.lastname: Zepf
authors.forename: S
authors.initials: S
authors.lastname: Schellmoser
authors.forename: W
authors.initials: W
authors.lastname: Rascher
authors.forename: H G
authors.initials: HG
authors.lastname: Dörr
mesh_terms: D002648:Child; D005260:Female; D006229:Hand Dermatoses / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000188:drug therapy; D013974:Thyroxine / Q000627:therapeutic use*; D014973:Xanthomatosis / Q000209:etiology*
chemical_list: D013974:Thyroxine