Cytochrome P450 pattern revision.
The pattern suggested for the structure-function superfamily of cytochromes P450 is composed by combining the conserved amino acid motifs. The sizes of P450 cytochromes were estimated according to their length. The empirical coefficients reflecting the peculiarities of the primary structure of these enzymes are calculated. We propose an approach for determining novel proteins sequences to the mentioned superfamily on the ground of the complex of these parameters. A number of the hypothetical proteins from the international databases is related to the cytochromes P450 by means of our pattern.
Buchatskii
A G
AG
Institute of Molecular Genetics, Russian Academy of Science, Moscow. q-q-q@rambler.ru
Kazachenko KYu
Alexandrov
A A
AA
D000595:Amino Acid Sequence; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry* / Q000235:genetics*; D030562:Databases, Protein; D006801:Humans; D008969:Molecular Sequence Data; D010363:Pattern Recognition, Automated; D016415:Sequence Alignment
D003577:Cytochrome P-450 Enzyme System