[Post-radiation compensatory peripheral expansion of hemopoiesis in Hodgkin's disease patients].
Development of peripheral expansion (PE) of hematopoiesis provides a basic mechanism of compensation for radiation-related damage to the bone marrow (BM) in radiation-treated patients with Hodgkin's disease. Radio nuclide visualization of BM established a significant correlation between PE degree and extent of BM damage. Among other things, it was found that hematopoiesis PE does not increase significantly until 35% of BM is involved and not until 12-24 months after radiotherapy; after 25 months and later, PE starts to subside. In patients under the age of 15, PE was triggered on at an earlier stage than in adults (within the first 12 months) and there was no correlation between the volume of exposed.
Kanaev
S V
SV
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Novikov
S N
SN
Zhukova
L A
LA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000528:radiation effects; D006410:Hematopoiesis / Q000528:radiation effects; D006689:Hodgkin Disease / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged