title: Regulated intramembrane proteolysis takes another twist.
abstract: Rhomboid, a seven-transmembrane domain protein, has been shown genetically to potentiate EGFR signaling via the TGFalpha-like ligand Spitz. Here we discuss recently published papers that identify Rhomboid as a novel serine protease, cleaving Spitz within its transmembrane domain.
authors.affiliation: Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: S
authors.initials: S
authors.lastname: Huppert
authors.forename: R
authors.initials: R
authors.lastname: Kopan
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D004330:Drosophila / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004815:Epidermal Growth Factor; D006056:Golgi Apparatus / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D008565:Membrane Proteins; C081481:Rho protein, Drosophila; C472498:Stet protein, Drosophila; C076026:spi protein, Drosophila; D004815:Epidermal Growth Factor; D012697:Serine Endopeptidases