title: Successful bone marrow transplantation for adult T-cell leukemia from a donor with oligoclonal proliferation of T-cells infected with human T-cell lymphotropic virus.
abstract: We describe a patient who underwent successful BMT from her sibling for the treatment of adult T-cell leukemia/lymphoma. Pre-transplant examination of the donor revealed oligoclonal integration of HTLV-I proviruses within the germ line, and our concern was that clinical sequelae of HLTV-I infection might become evident in the setting of post-transplant immunosuppression. However, the patient has been in complete remission for 14 months after transplantation, and no clonality of HTLV-I provirus was detected in the peripheral blood cells using southern blotting analysis. Our experience supports the possibility of transplantation from HTLV-I positive donors.
authors.affiliation: Department of Hematology, Toranomon Hospital, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kishi
authors.forename: M
authors.initials: M
authors.lastname: Kami
authors.forename: Y
authors.initials: Y
authors.lastname: Oki
authors.forename: T
authors.initials: T
authors.lastname: Hamaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kanda
authors.forename: U
authors.initials: U
authors.lastname: Machida
authors.forename: S
authors.initials: S
authors.lastname: Miyakoshi
authors.forename: J
authors.initials: J
authors.lastname: Ueyama
authors.forename: S
authors.initials: S
authors.lastname: Morinaga
authors.forename: Y
authors.initials: Y
authors.lastname: Muto
mesh_terms: D016026:Bone Marrow Transplantation; D002455:Cell Division; D002999:Clone Cells / Q000473:pathology / Q000821:virology; D005260:Female; D015490:HTLV-I Infections / Q000635:transmission; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000628:therapy*; D008875:Middle Aged; D012074:Remission Induction; D013601:T-Lymphocytes / Q000473:pathology / Q000821:virology; D014019:Tissue Donors