Aggregation of insulin by chlorpromazine.
Chlorpromazine (CPZ) is known to induce hyperglycaemia and can inhibit insulin secretion in both normal subjects and patients with latent diabetes mellitus. In this study, we have tried to determine a probable mechanism by which CPZ causes hyperglycaemia. It is possible that CPZ causes insulin aggregation by the reduction of disulphide bonds, thereby inactivating insulin and hence causing hyperglycaemia.
Bhattacharyya
J
J
Protein Chemistry Laboratory, Department of Chemistry, Bose Institute, 93/1 Acharyya Prafulla Chandra Road, 700 009, Calcutta, India. bhattacharyyaj@health.missouri.edu
Das
K P
KP
D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology; D002417:Cattle; D002746:Chlorpromazine / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D007328:Insulin / Q000378:metabolism*; D007700:Kinetics
D014150:Antipsychotic Agents; D007328:Insulin; D002746:Chlorpromazine