Triazolo- and tetrazolopyridazine derivatives and their hypotension and heart rate activity.
6-Chloro-, 6-morpholino- and 6-N-methylpiperazino-1,2,4-triazolo[4,3-b]- or 1,2,3,4-tetrazolo[1,5-b]pyridazines [II-VII] were synthesized from 3-chloro-6-hydrazinopyridazine [I]. Positive effect of a series of tetra- and triazolopyridazines for lowering blood-pressure without affecting the heart rate was found in tests on rats. Their lipophilicity and other properties are discussed.
Katrusiak
A
A
Department of Organic Chemistry, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Melzer
E
E
Bałoniak
S
S
Bobkiewicz
T
T
Polcyn
P
P
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006339:Heart Rate / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011921:Rats, Inbred WKY
D000959:Antihypertensive Agents; D011724:Pyridazines