title: Reversible posterior leukoencephalopathy syndrome following CHOP chemotherapy for diffuse large B-cell lymphoma.
abstract: A 63-year-old female with stage IE diffuse large B-cell lymphoma developed reversible posterior leukoencephalopathy syndrome (RPLS) following CHOP chemotherapy, with typical clinical and radiological findings. RPLS is a rare neurological syndrome characterised by visual disturbances, seizures, headaches and altered conscious level which has been associated with malignant hypertension, pre-eclampsia and some drugs, including ciclosporin. It has not been previously reported following CHOP chemotherapy. Alternative treatment should be considered for patients who develop this rare complication.
authors.affiliation: Department of Medical Oncology, St Bartholomew's Hospital, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Edwards
authors.forename: R
authors.initials: R
authors.lastname: Walker
authors.forename: S
authors.initials: S
authors.lastname: Vinnicombe
authors.forename: C
authors.initials: C
authors.lastname: Barlow
authors.forename: P
authors.initials: P
authors.lastname: MacCallum
authors.forename: J M
authors.initials: JM
authors.lastname: Foran
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D001927:Brain Diseases / Q000139:chemically induced*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D012640:Seizures / Q000209:etiology; D013577:Syndrome; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone