title: Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.
abstract: We have identified an alternate developmental pathway in the life cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immunodeficient hosts in which the parasite fails to receive appropriate signals from the host immune system. Helminth development is altered at an early stage during infection, resulting in the appearance of attenuated forms that prolong survival of host and parasite. Hepatic CD4+ T lymphocyte populations are an integral component of the immune signal recognized by the parasite.
authors.affiliation: Tropical Disease Research Unit, Department of Pathology, Veterans Affairs Medical Center, Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California San Francisco, CA 94143, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Davies
authors.forename: J L
authors.initials: JL
authors.lastname: Grogan
authors.forename: R B
authors.initials: RB
authors.lastname: Blank
authors.forename: K C
authors.initials: KC
authors.lastname: Lim
authors.forename: R M
authors.initials: RM
authors.lastname: Locksley
authors.forename: J H
authors.initials: JH
authors.lastname: McKerrow
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005802:Genes, MHC Class II; D008099:Liver / Q000276:immunology / Q000469:parasitology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D012549:Schistosoma japonicum / Q000033:anatomy & histology / Q000254:growth & development; D012550:Schistosoma mansoni / Q000254:growth & development* / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology* / Q000469:parasitology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D001613:beta 2-Microglobulin / Q000235:genetics / Q000502:physiology
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D001613:beta 2-Microglobulin