Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans.
To investigate the possible involvement of the butyrylcholinesterase (BCHE) K variant and transferrin (TF) C2 variant in the manifestation of Alzheimer's disease (AD), we analyzed the BCHE, TF and apolipoprotein E (APOE) genotypes of 164 sporadic AD patients and 239 normal elderly controls. The frequencies of the BCHE K and TF C2 did not differ between the AD patients and controls (P > 0.1). The occurrence of the APOE epsilon4 did not influence the distribution of the BCHE K and TF C2 variants (P > 0.1). No linkage disequilibrium between the BCHE K and TF C2 was observed either in both the AD patients and controls (P > 0.1). In conclusion, neither the BCHE K nor the TF C2 confers a risk for AD.
Kim
K W
KW
Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Korea.
Jhoo
J H
JH
Lee
J H
JH
Lee
K U
KU
Lee
D Y
DY
Youn
J C
JC
Youn
J Y
JY
Woo
J I
JI
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D000704:Analysis of Variance; D002091:Butyrylcholinesterase / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007723:Korea; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D014168:Transferrin / Q000235:genetics*
D014168:Transferrin; D002091:Butyrylcholinesterase