Effects of simvastatin on the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia.
We studied the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia before and after treatment with simvastatin. Individual phospholipids were separated by thin-layer chromatography on glass plates coated with silica gel. It was found that apart from hypolipidemic effect, simvastatin changed the concentration and phospholipid composition of high-density lipoproteins, which improved their cholesterol-accepting and cholesterol-transporting properties.
Ozerova
I N
IN
Department of Metabolic Disorders, State Research Center of Preventive Medicine, Russian Ministry of Health, Moscow.
Paramonova
I V
IV
Olfer'ev
A M
AM
Akhmedzhanov
N M
NM
Aleksandrova
M A
MA
Perova
N V
NV
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002308:Cardiolipins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000737:chemistry*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008244:Lysophosphatidylcholines / Q000097:blood; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood; D010714:Phosphatidylethanolamines / Q000097:blood; D010743:Phospholipids / Q000032:analysis / Q000097:blood*; D019821:Simvastatin / Q000494:pharmacology*; D013109:Sphingomyelins / Q000097:blood; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D002308:Cardiolipins; D008076:Cholesterol, HDL; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D013109:Sphingomyelins; D014280:Triglycerides; D002784:Cholesterol; D019821:Simvastatin