Iron metabolism: iron deficiency and iron overload.
Iron is an essential cofactor in a variety of cellular processes. Except for a few unusual bacterial species, iron is indispensable for living organisms. However, free iron is toxic because of its propensity to induce the formation of dangerous free radicals. Consequently, iron balance is tightly regulated. Disorders of iron homeostasis are among the most common afflictions of humans. This review discusses inherited iron deficiency and iron overload disorders and recent insights into their pathophysiology.
Andrews
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NC
Howard Hughes Medical Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA. nandrews@genetics.med.harvard.edu
D018798:Anemia, Iron-Deficiency / Q000378:metabolism; D000756:Anemia, Sideroblastic / Q000235:genetics; D000818:Animals; D006706:Homeostasis; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism*; D000090463:Iron Deficiencies; D019189:Iron Metabolism Disorders / Q000235:genetics / Q000378:metabolism*; D019190:Iron Overload / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D014168:Transferrin / Q000378:metabolism
D014168:Transferrin; D007501:Iron