title: Piperacillin/Tazobactam versus cefotaxime plus metronidazole for treatment of children with intra-abdominal infections requiring surgery.
abstract: The efficacy of piperacillin/tazobactam at 100/12.5 mg/kg every 8 h (35 patients) was compared to cefotaxime plus metronidazole at 50/7.5 mg/kg every 8 h (35 patients) in 70 children with intra-abdominal infections requiring surgery. Diagnoses were gangrenous or perforated appendicitis (n =56), peritonitis (n =12), and abscess (n =2). Clinical cure was observed in 35 of 35 evaluable patients treated with piperacilin/tazobactam and in 34 of 34 evaluable patients treated with cefotaxime plus metronidazole. Presumed bacteriological eradication was noted in 29 of 30 evaluable patients in the piperacillin/tazobactam group and in 31 of 31 evaluable patients in the cefotaxime plus metronidazole group. In this study, piperacillin/tazobactam was as effective as cefotaxime plus metronidazole for treating children with intra-abdominal infections requiring surgery.
authors.affiliation: University of Athens Second Department of Pediatrics, P. & A. Kyriakou Children's Hospital, Athens, Greece.
authors.forename: H C
authors.initials: HC
authors.lastname: Maltezou
authors.forename: P
authors.initials: P
authors.lastname: Nikolaidis
authors.forename: E
authors.initials: E
authors.lastname: Lebesii
authors.forename: L
authors.initials: L
authors.lastname: Dimitriou
authors.forename: E
authors.initials: E
authors.lastname: Androulakakis
authors.forename: D A
authors.initials: DA
authors.lastname: Kafetzis
mesh_terms: D018784:Abdominal Abscess / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D000293:Adolescent; D001064:Appendicitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002439:Cefotaxime / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007416:Intestinal Perforation / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010538:Peritonitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D010878:Piperacillin / Q000008:administration & dosage; D011446:Prospective Studies; D000078142:Tazobactam; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D008795:Metronidazole; D010397:Penicillanic Acid; D002439:Cefotaxime; D000078142:Tazobactam; D010878:Piperacillin