[The preparation phosprenyl suppresses diarrhea and cattle infectious rhinotracheitis virus multiplication in sensitive cell cultures].
Fosprenil suppressed the multiplication of cattle diarrhea virus in calf coronary vessel cell culture. Added to the culture of infected cells in a dose of 200 mg, the drug decreased the virus titer 30-fold in comparison with infected control cultures. Antiviral activity of fosprenil towards infective rhinotracheitis virus multiplication was still higher: in a dose of 100 mg it decreased the virus titer in fetal calf lung culture 100-fold in comparison with the control. Moreover, the cytopathogenic effects of the viruses in infected cultures were 24-48 h delayed under the effect of fosprenil in comparison with infected control cultures. These results recommend fosprenil for the treatment of cattle viral diseases.
Ozherelkov
S V
SV
Belousova
R V
RV
Danilov
L L
LL
Deeva
A V
AV
Mal'tsev
S D
SD
Narovlianskiĭ
A N
AN
Sanin
A V
AV
Pronin
A V
AV
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects* / Q000472:pathogenicity; D007242:Herpesvirus 1, Bovine / Q000187:drug effects* / Q000472:pathogenicity; D007241:Infectious Bovine Rhinotracheitis / Q000821:virology*; D011106:Polyisoprenyl Phosphates / Q000494:pharmacology*
D000998:Antiviral Agents; D011106:Polyisoprenyl Phosphates; C105485:phosprenyl