title: Increased p53 mutation frequency during tumor progression--results from a breast cancer cohort.
abstract: The mutational patterns of the p53 gene for exons 4-9 were analyzed in 30 recurring tumors compared with the p53 status of the corresponding 30 primary breast cancers. The prevalence of p53 mutations was higher, although not statistically significant (P = 0.07), in the evaluable recurring tumors compared with the corresponding primaries, 12 of 29 (41%) versus 7 of 30 (23%). Twenty-one of the patients had unchanged p53 mutation status in the recurring compared with the primary tumors, whereas 8 had an altered mutational status or pattern in the sequential tumor. These findings indicate that p53 mutations may be an important factor for tumor progression in human breast cancer.
authors.affiliation: Department of Oncology, Radiumhemmet, Karolinska Institute and Hospital, Stockholm, Sweden S-17176.
authors.forename: T
authors.initials: T
authors.lastname: Norberg
authors.forename: S
authors.initials: S
authors.lastname: Klaar
authors.forename: G
authors.initials: G
authors.lastname: Kärf
authors.forename: H
authors.initials: H
authors.lastname: Nordgren
authors.forename: L
authors.initials: L
authors.lastname: Holmberg
authors.forename: J
authors.initials: J
authors.lastname: Bergh
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology