Interleukin-1 receptor antagonist gene therapy for arthritis.
Rheumtatoid arthritis (RA) is a crippling, autoimmune disease, and is characterized by inflammation and destruction of joint tissue. Interleukin-1 (IL-1) has been identified as a key pro-inflammatory cytokine responsible for inflammation. One of the mechanisms of regulation of activity of IL-1 is IL-1 receptor antagonist (IL-1ra)-mediated: IL-1RA competes with IL-1 for binding to the IL-1 receptor. Significant progress has been made in the potential application of IL-1ra gene therapyfor the treatment of arthritis. Various vectors have been tested for the delivery of the IL-1ra gene to the intra-articular region. Recent studies in humans have provided encouraging prospects for IL-1ra-mediated arthritis gene therapy.
Krishnan
B R
BR
Pfizer Central Research, AH Biological Discovery, Groton, CT 06340, USA. krishnanr@groton.pfizer.com
D000818:Animals; D001169:Arthritis, Experimental / Q000628:therapy; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000628:therapy*; D001327:Autoimmune Diseases / Q000235:genetics / Q000628:therapy*; D002461:Cell Line, Transformed / Q000378:metabolism / Q000637:transplantation; D002986:Clinical Trials as Topic; D004274:DNA, Recombinant / Q000008:administration & dosage / Q000235:genetics / Q000627:therapeutic use; D004285:Dogs; D017930:Genes, Reporter; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000008:administration & dosage / Q000235:genetics / Q000627:therapeutic use*; D006801:Humans; D007270:Injections, Intra-Articular; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000502:physiology; D051379:Mice; D011817:Rabbits; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000502:physiology; D012190:Retroviridae / Q000235:genetics; D012795:Sialoglycoproteins / Q000235:genetics* / Q000502:physiology; D018139:Simplexvirus / Q000235:genetics; D013583:Synovial Membrane / Q000473:pathology; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D004274:DNA, Recombinant; C507763:IL1RN protein, human; C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D011993:Recombinant Fusion Proteins; D012795:Sialoglycoproteins