title: Therapeutic aspects of tolerance.
abstract: The immune system is naturally unresponsive to 'self' antigens. Improved knowledge of mechanisms underlying self tolerance is giving rise to a new generation of immunosuppressive agents, that can exploit these mechanisms and so reduce the nature and level of medication that needs to be given long-term to control diseases where the immune system does harm.
authors.affiliation: Sir William Dunn School of Pathology, Oxford, UK. herman.waldmann@path.ox.ac.uk
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
authors.forename: S P
authors.initials: SP
authors.lastname: Cobbold
authors.forename: P
authors.initials: P
authors.lastname: Fairchild
authors.forename: E
authors.initials: E
authors.lastname: Adams
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D000954:Antigens, Surface / Q000187:drug effects / Q000276:immunology; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects* / Q000502:physiology*; D007112:Immunity, Maternally-Acquired; D016377:Organ Transplantation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface