Tissue oxygen sensor function of NADPH oxidase isoforms, an unusual cytochrome aa3 and reactive oxygen species.
NADPH oxidase isoforms with different gp91phox subunits as well as an unusual cytochrome aa3 with a heme a/a3 relationship of 9:91 are discussed as putative oxygen sensor proteins influencing gene expression and ion channel conductivity. Reactive oxygen species (ROS) are important second messengers of the oxygen sensing signal cascade determining the stability of transcription factors or the gating of ion channels. The formation of ROS by a perinuclear Fenton reaction is imaged by 1 and 2 photon confocal microscopy revealing mitochondrial and non-mitochondrial generation.
Porwol
T
T
Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn Str. 11, D-44227, Dortmund, Germany.
Ehleben
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W
Brand
V
V
Acker
H
H
D000818:Animals; D006528:Carcinoma, Hepatocellular; D002344:Carotid Body / Q000378:metabolism*; D002628:Chemoreceptor Cells / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism*; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D006861:Hydrogen Peroxide; D000860:Hypoxia / Q000378:metabolism; D007501:Iron; D007527:Isoenzymes / Q000378:metabolism*; D008113:Liver Neoplasms; D019255:NADPH Oxidases / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D014407:Tumor Cells, Cultured
C045076:Fenton's reagent; D007527:Isoenzymes; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D007501:Iron; D019255:NADPH Oxidases; D003576:Electron Transport Complex IV; D010100:Oxygen