title: Assessment of alcohol tolerance in adolescents.
abstract: OBJECTIVE
  To improve assessment of the DSM-IV alcohol tolerance criterion in adolescents, this study tested the performance of a minimum percentage increase in drinking quantity, and a proxy measure of tolerance (i.e., average heavy-drinking quantity per occasion) in identifying adolescents with alcohol dependence.
  
  
  METHODS
  Two adolescent samples were examined. In one sample (N = 415, 58% male, 79% white, 57% clinical), a modified version of the SCID was used to determine DSM-IV alcohol diagnoses, and lifetime drinking history data were collected by interview. In the second sample (N = 470, 60% male, 76% white, 100% clinical), the Adolescent Diagnostic Interview was used to determine DSM-IV alcohol diagnoses and to collect data on initial- and current-drinking quantities needed to become intoxicated. The performance of a percentage increase and average heavy-drinking quantity in identifying those with dependence was evaluated using receiver operating characteristic analysis.
  
  
  RESULTS
  The utility of a percentage increase definition was limited by the high degree of variability in initial-drinking quantities. Percentage increase may underassign the tolerance symptom when initial-drinking quantities are high and overassign the symptom when initial-drinking quantities are low. Average heavy-drinking quantity per occasion, combined with a minimum frequency of drinking, demonstrated better performance than any percentage increase definition.
  
  
  CONCLUSIONS
  Alternatives to a change-based (e.g., percentage increase) definition of tolerance warrant study due to limits of change-based definitions when initial-drinking quantity shows a high degree of variability. The variability in initial-drinking quantity may reflect individual differences in initial sensitivity that need to be considered in tolerance assessment.
authors.affiliation: Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA. chungta@msx.upmc.edu
authors.forename: T
authors.initials: T
authors.lastname: Chung
authors.forename: C S
authors.initials: CS
authors.lastname: Martin
authors.forename: K C
authors.initials: KC
authors.lastname: Winters
authors.forename: J W
authors.initials: JW
authors.lastname: Langenbucher
mesh_terms: D000293:Adolescent; D000437:Alcoholism / Q000175:diagnosis* / Q000453:epidemiology*; D004361:Drug Tolerance; D000431:Ethanol; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D011569:Psychiatric Status Rating Scales
chemical_list: D000431:Ethanol