Nocturnal blood pressure dip in CADASIL.
The influence of a nocturnal blood pressure dip on cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) has not yet been clarified. We attempted to examine a correlation with the nocturnal blood pressure dip and CADASIL. We monitored circadian blood pressure patterns by the use of a portable blood pressure monitoring device in five patients with CADASIL and 10 age- and sex-matched control subjects. Based on nocturnal fall in mean arterial blood pressure (MABP), we classified patients into extreme dippers (nocturnal reduction of MABP > or =20%), dippers (> or =10% but <20%), nondippers (<10% but > or =0%), and inverted dippers (<0%). Three patients revealed non-dipper and two inverted dipper. Nighttime MABP fall was significantly lower in patients compared with control subjects (P<0.01). This study suggests that a lower nocturnal blood pressure fall may be partly associated with incidence and/or worsening of deep white matter lesions in CADASIL.
Manabe
Y
Y
Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, 700-8558, Okayama, Japan. manabe@cc.okayama-u.ac.jp
Murakami
T
T
Iwatsuki
K
K
Narai
H
H
Warita
H
H
Hayashi
T
T
Shoji
M
M
Imai
Y
Y
Abe
K
K
D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D021081:Chronobiology Disorders / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D015161:Dementia, Multi-Infarct / Q000150:complications* / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000235:genetics; D011956:Receptors, Cell Surface; D012307:Risk Factors
D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface