title: Stress hormone secretion and gut signal transducer (STAT) proteins after burn injury in rats.
abstract: A burn injury triggers traumatic reactions characteristics of a stress. Here we investigated the early responses of prolactin (PRL), corticosterone (CS), and signal transducer and activator of transcription 5 (STAT5) in male Sprague-Dawley rats after burn injury. PRL and CS levels were determined in blood serum. STAT5 and phospho-STAT5 levels were determined in jejunum total protein extracts. The results confirmed an expected increase of CS between 4 and 6 h after the burn injury. Unexpectedly, PRL secretion was suppressed during the same time frame. These hormone levels returned to normal 6 to 8 h after burn injury. STAT5 was increased in the jejunum after burn injury, and its phosphorylation was increased between 8 and 11 h after burn injury. These changes in STAT5 were not temporally correlated with either the hormone changes that we observed or with previously documented changes of the gut function after burns.
authors.affiliation: Department of Molecular and Cellular Physiology, University of Cincinnati, 231 Bethesda Avenue, Cincinnati, OH 45267-0576, USA.
authors.forename: O
authors.initials: O
authors.lastname: Thellin
authors.forename: G
authors.initials: G
authors.lastname: Noel
authors.forename: S
authors.initials: S
authors.lastname: Khurana
authors.forename: C K
authors.initials: CK
authors.lastname: Ogle
authors.forename: N D
authors.initials: ND
authors.lastname: Horseman
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002056:Burns / Q000097:blood / Q000503:physiopathology*; D016466:CHO Cells; D002940:Circadian Rhythm; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D006224:Cricetinae; D004268:DNA-Binding Proteins / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism; D007583:Jejunum / Q000293:injuries*; D008264:Macrophages / Q000502:physiology; D008894:Milk Proteins; D009000:Monocytes / Q000502:physiology; D010766:Phosphorylation; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D050799:STAT5 Transcription Factor; D015398:Signal Transduction / Q000502:physiology*; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology*; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D008894:Milk Proteins; D050799:STAT5 Transcription Factor; D015534:Trans-Activators; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone; D003345:Corticosterone