Synthesis of antitumor dendritic imides.
Dendritic imides were synthesized and evaluated as antitumor compounds. Compounds 8 and 11 showing a promising profile as inhibitors of lck but their antiproliferative activity against HT-29 was not so relevant.
Braña
M F
MF
Department of Organic and Pharmaceutical Chemistry, University San Pablo-CEU, Boadilla del Monte 28668, Madrid, Spain. mfbrana@ceu.es
Domínguez
G
G
Sáez
B
B
Romerdahl
C
C
Robinson
S
S
Barlozzari
T
T
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002277:Carcinoma / Q000188:drug therapy; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007094:Imides / Q000737:chemistry* / Q000494:pharmacology*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D007094:Imides; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)