Cocaine withdrawal in Planaria.
Cocaine-exposed planarians displayed abstinence-induced withdrawal behavior when placed into cocaine-free, but not cocaine-containing, water. The effect, manifested and quantified using a new spontaneous locomotor velocity metric, was dose-dependently related to cocaine exposure (8x10(-9) to 8x10(-5) M). Ultraviolet light (254 nm=7.83x10(-19) J), which was previously shown to interfere with drug-receptor interactions in Planaria, enhanced the abstinence-induced decreased locomotor velocity.
Raffa
R B
RB
Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA. rraffa@nimbus.temple.edu
Valdez
J M
JM
D000818:Animals; D003042:Cocaine / Q000633:toxicity*; D004195:Disease Models, Animal; D008124:Locomotion / Q000187:drug effects; D010932:Planarians / Q000187:drug effects* / Q000528:radiation effects; D013696:Temperature; D014466:Ultraviolet Rays
D003042:Cocaine