Restenosis after percutaneous transluminal angioplasty in the femoropopliteal segment: the role of inflammation.
OBJECTIVE
To determine the value of baseline C-reactive protein (CPR), fibrinogen, and white blood cell (WBC) counts in predicting 1-year patency after percutaneous transluminal angioplasty (PTA) in the femoropopliteal segment.


METHODS
In a retrospective cohort study, 168 consecutive patients (103 men; median age 70 years, interquartile range 61-77) who underwent successful PTA of the femoral and/or popliteal arteries were analyzed. Twelve-month patency was evaluated using oscillography, ankle brachial index, duplex sonography, and angiography. The predictive value of inflammatory markers was assessed in a multivariate model controlling for cardiovascular risk factors, technical success, and hemodynamic factors.


RESULTS
Transient WBC elevation was found 6 hours after PTA, but this returned to baseline after 24 hours. Fibrinogen was elevated at 24 hours. Duplex scanning disclosed restenosis in 66 (39%) patients within the first 12 months after PTA. Only residual postdilation stenosis (> or = 30%) in the target segment (odds ratio 3.6, p=0.001) and baseline CRP levels (odds ratio 4.2, p=0.02) were independent predictors of outcome; neither WBC counts nor fibrinogen levels at any time point was associated with restenosis.


CONCLUSIONS
Primary technical success and postinterventional hemodynamic flow at the dilated segment seem to be more important for intermediate-term patency than atherogenic risk factors. The predictive value of preprocedural serum CRP levels on restenosis should be further investigated.
Schillinger
M
M
Department of Angiology, University of Vienna Medical School, Austria. martin.schillinger@akh-wien.ac.at
Haumer
M
M
Schlerka
G
G
Mlekusch
W
W
Exner
M
M
Ahmadi
R
R
Minar
E
E
D000368:Aged; D000800:Angioplasty, Balloon / Q000009:adverse effects*; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D003251:Constriction, Pathologic / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology* / Q000601:surgery*; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery / Q000503:physiopathology* / Q000601:surgery*; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors; D014654:Vascular Patency / Q000502:physiology*
D005340:Fibrinogen; D002097:C-Reactive Protein