Effects of the quantity of water and milk ingested concomitantly with AS-924, a novel ester-type cephem antibiotic, on its pharmacokinetics.
The effect of the quantity of water ingested concomitantly with drugs, on the absorption of AS-924, a novel prodrug-type cephem antibiotic, was studied in five healthy adult volunteers by a cross-over method, using cefteram-pivoxil (CTER-PI) as the control drug. In addition, the effect of milk on the absorption of AS-924 was also investigated. The absorption of CTER-PI was significantly reduced when administered together with 30 ml of water compared with its absorption when administered together with 150 ml of water, whereas no such reduction was found in the case of AS-924. Ingestion of milk did not significantly affect the absorption of AS-924. These results confirm that absorption of AS-924 after oral administration is not likely to be affected by the quantity of water taken concomitantly with the drug, nor by milk.
Matsumoto
F
F
Kanagawa Prefecture Midwives and Nurses Training School Hospital, 1-6-5, Shiomidai, Isogo-ku, 235-0022, Kanagawa, Japan.
Sakurai
I
I
Morita
M
M
Takahashi
T
T
Mori
N
N
Sugihara
T
T
Sakai
A
A
Yamaji
S
S
Akaike
Y
Y
Yano
K
K
D000284:Administration, Oral; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D015281:Cefmenoxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D015296:Ceftizoxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D018565:Food-Drug Interactions; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008892:Milk / Q000378:metabolism*; D011355:Prodrugs / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors; D014556:Urine / Q000737:chemistry; D014867:Water / Q000008:administration & dosage / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D011355:Prodrugs; D014867:Water; C046817:cefteram pivoxil; C121334:ceftizoxime alapivoxil; D015296:Ceftizoxime; D015281:Cefmenoxime