Altered nuclear transport and the most selfish of genes.
The Segregation Distorter System in Drosophila is one of the best-known and genetically characterized systems of meiotic drive. A recent paper by Kusano et al. (2001) provides a key molecular insight into the molecular mechanism by which one chromosome can ensure the destruction of its partner.
Hawley
R S
RS
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D020090:Chromosome Segregation; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005260:Female; D020690:GTPase-Activating Proteins / Q000235:genetics / Q000378:metabolism*; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D008540:Meiosis; D012091:Repetitive Sequences, Nucleic Acid
D029721:Drosophila Proteins; D020690:GTPase-Activating Proteins; D019476:Insect Proteins; C118002:RanGAP protein, Drosophila