Identification of a new HLA-DRB1*04 allele, DRB1*0437.
In this report we describe the identification of a novel DRB1*04 allele, DRB1*0437, found in a Spanish individual. The routine HLA typing, in the context of bone marrow transplantation, by polymerase chain reaction-sequence-based typing (PCR-SBT) made possible the identification of this new allele. This allele is identical to DRB1*0402 except for a single nucleotide substitution at position 286 (A-->C), changing the encoded Isoleucine to a Leucine. The DRB1*0437 allele conserves the same two acidic residues at codons 70 and 71 that confer to DRB1*0402 its association to some autoimmune diseases.
Palou
E
E
Servei d'Immunohematologia, Centre de Transfusió i Banc de Teixits, Pg. Vall d'Hebron 119-129, 08035 Barcelona, Spain. epalou@hg.vhebron.es
Campos
E
E
Gil
J
J
Santos
M
M
Nogués
N
N
Ribera
A
A
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D005260:Female; D005805:Genes, MHC Class I; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017385:Sequence Homology
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553506:HLA-DRB1*04:02 antigen