Macrophage Stimulator beta-(1-->3)-D-carboxymethylglucan improves the efficiency of chemotherapy of Lewis lung carcinoma.
We studied the effect of macrophage stimulator water-soluble beta-(1-->3)-D-carboxymethylglucan on the efficiency of cyclophosphamide chemotherapy in Lewis lung carcinoma. Cyclophosphamide inhibited the growth of primary tumor nodes by 57%. The preparation possessed pronounced antimetastatic activity: metastases were found in 40.9% animals. Combination therapy with cyclophosphamide and (1-->3)-beta;-D-glucan inhibited the growth of intramuscular tumors by 75-89% and reduced the incidence of metastases into the lungs by 92-94%. The therapeutic effect was most pronounced after simultaneous administration of these preparations: tumor growth was suppressed by 89.3% and metastases were found in only 7.5% animals (vs. 100% in the control). The potentiating effect of beta-(1-->3)-D-carboxymethylglucan is related to accumulation of cysteine proteinase inhibitors in the tumor tissue and plasma, but not to changes in blood cell composition.
Falameeva
O V
OV
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Poteryaeva
O N
ON
Zhanaeva
S Y
SY
Levina
O A
OA
Filatova
T G
TG
Korolenko
T A
TA
Kaledin
V I
VI
Sandula
I
I
Kogan
G
G
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002401:Cathepsin B / Q000032:analysis; D056668:Cathepsin L; D002403:Cathepsins / Q000032:analysis; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D055312:Cystatin A; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D003546:Cysteine Endopeptidases; D004357:Drug Synergism; D005936:Glucans / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D008175:Lung Neoplasms / Q000556:secondary; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D047071:beta-Glucans
D018906:Antineoplastic Agents, Alkylating; C525031:Cst3 protein, mouse; C501463:Csta1 protein, mouse; D055312:Cystatin A; D055316:Cystatin C; D015891:Cystatins; D005936:Glucans; D047071:beta-Glucans; C029933:carboxymethyl-beta-1,3-glucan; D003520:Cyclophosphamide; D002403:Cathepsins; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D056668:Cathepsin L; C534278:Ctsl protein, mouse