title: Biomedical study on combined effects of simulated weightlessness and emergent depressurization of spacecraft.
abstract: Cabin emergent depressurization (CED) may occur in spacecraft during manned space flight. The purpose of this paper was to study the combined effects of simulated weightlessness (SW) and CED factors on humans and animals. It was found that the amplitude of T wave of human electrocardiograms (ECG) significantly decreased in bed rest and hypoxia compared with the control condition (P<0.05), and that suspension with pure O2 induced severer edema in the lungs of rats than that in only a pure O2 environment. SW and pure O2 caused middle ear congestion and decreased the barofunction during pressure changes. These results indicate that human response to CED factors become more serious under SW because of the blood redistribution.
authors.affiliation: Institute of Space Medico-Engineering, Beijing P.O. Box 5104, 100094, P.R. China.
authors.forename: T D
authors.initials: TD
authors.lastname: Yang
authors.forename: R G
authors.initials: RG
authors.lastname: Zhang
authors.forename: C M
authors.initials: CM
authors.lastname: Wang
authors.forename: H W
authors.initials: HW
authors.lastname: Fu
authors.forename: B L
authors.initials: BL
authors.lastname: Zhang
authors.forename: J X
authors.initials: JX
authors.lastname: Zhang
mesh_terms: D000337:Aerospace Medicine; D000818:Animals; D001469:Barotrauma / Q000209:etiology / Q000503:physiopathology; D001510:Bed Rest; D003664:Decompression / Q000009:adverse effects*; D004562:Electrocardiography; D018495:Fluid Shifts / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008168:Lung / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D010100:Oxygen / Q000009:adverse effects*; D010102:Oxygen Inhalation Therapy; D011654:Pulmonary Edema / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D019442:Space Suits; D018474:Weightlessness Simulation / Q000009:adverse effects*
chemical_list: D010100:Oxygen