[A case of carbamazepine intoxication with alpha coma and status epilepticus].
We report a 14-year-old girl with carbamazepine intoxication who developed alpha coma and status epilepticus. She fell into deep coma and developed frequent generalized convulsions. The EEG during coma showed diffuse alpha activity predominantly in the frontal area. Serum carbamazepine concentration was 42.8 micrograms/ml. The convulsions were suppressed by diazepam only transiently, and by midazolam completely. Although half a day had passed since carbamazepine ingestion, we could wash out much of drug remnants by gastric lavage. Thereafter, the serum concentration of carbamazepine decreased efficiently and the patient recovered dramatically without complication. Early diagnosis and appropriate treatments should improve the prognosis of carbamazepine intoxication.
Ono
A
A
Department of Pediatrics, Akita University School of Medicine, Akita.
Yano
T
T
Sawaishi
Y
Y
Komatsu
K
K
Takada
G
G
D000293:Adolescent; D002220:Carbamazepine / Q000506:poisoning*; D002606:Charcoal / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D004569:Electroencephalography; D005260:Female; D005751:Gastric Lavage; D006801:Humans; D008874:Midazolam / Q000627:therapeutic use; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome
D002606:Charcoal; D002220:Carbamazepine; D008874:Midazolam