title: Increased QT dispersion in hemodialysis patients improve after renal transplantation: a prospective-controlled study.
abstract: Increased QT dispersion (QTd), predicting patients with risk of malignant arrhythmia, have recently been reported in hemodialysis patients (HDp). In this prospective study, we aimed to investigate changes in QTd and signal averaged-ECG (SAECG) in HDp after transplantation. Twenty-seven HDp (M/F:18/9, mean age 30+/-8 years) and 24 controls (M/F:14/10, mean age 33+/-6 years) were included. All QT parameters (QTmax, Qtmin, and QTd) were increased in HDp. QTmax and QTd started to decrease at the first month after transplantation. Percentage change in QTd at the third month was significantly correlated with percentage change in LV mass index (r=0.45, P=0.04), serum calcium (r=-0.47, P=0.02) and intact parathyroid hormone (r=0.68, P=0.01). In multivariate regression analysis, only percent chance in LV mass index was retained as significant. As for analysis of SAECG, 4 of the 23 (17%) HDp has abnormal late potentials which disappeared after transplantation. HDp with LV hypertrophy had higher filtered-QRS duration compared to patients without hypertrophy (110+/-12 vs. 97+/-11 msec, P=0.01). It was concluded that increased QTd and presence of late potentials improved early after renal transplantation. These changes were mainly associated with the regression of the LV mass.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Istanbul School of Medicine, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Yildiz
authors.forename: V
authors.initials: V
authors.lastname: Akkaya
authors.forename: T
authors.initials: T
authors.lastname: Tükek
authors.forename: S
authors.initials: S
authors.lastname: Sahin
authors.forename: M S
authors.initials: MS
authors.lastname: Sever
authors.forename: S
authors.initials: S
authors.lastname: Bozfakioğlu
authors.forename: F
authors.initials: F
authors.lastname: Korkut
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000503:physiopathology* / Q000628:therapy; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D004562:Electrocardiography; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000145:classification* / Q000601:surgery; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D015999:Multivariate Analysis; D011446:Prospective Studies; D012016:Reference Values; D012044:Regression Analysis; D006435:Renal Dialysis
chemical_list: D004573:Electrolytes