title: Triazolo- and tetrazolopyridazine derivatives and their hypotension and heart rate activity.
abstract: 6-Chloro-, 6-morpholino- and 6-N-methylpiperazino-1,2,4-triazolo[4,3-b]- or 1,2,3,4-tetrazolo[1,5-b]pyridazines [II-VII] were synthesized from 3-chloro-6-hydrazinopyridazine [I]. Positive effect of a series of tetra- and triazolopyridazines for lowering blood-pressure without affecting the heart rate was found in tests on rats. Their lipophilicity and other properties are discussed.
authors.affiliation: Department of Organic Chemistry, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Katrusiak
authors.forename: E
authors.initials: E
authors.lastname: Melzer
authors.forename: S
authors.initials: S
authors.lastname: Bałoniak
authors.forename: T
authors.initials: T
authors.lastname: Bobkiewicz
authors.forename: P
authors.initials: P
authors.lastname: Polcyn
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006339:Heart Rate / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011921:Rats, Inbred WKY
chemical_list: D000959:Antihypertensive Agents; D011724:Pyridazines