title: Low dose dobutamine echocardiography for predicting functional recovery after coronary revascularisation.
abstract: OBJECTIVE
  To evaluate the effects of chronic coronary occlusion on the accuracy of low dose dobutamine echocardiography in predicting recovery of dysfunctional myocardium after revascularisation.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Tertiary referral centre.
  
  
  METHODS
  53 consecutive patients with >/= 70% stenosis of the left anterior descending coronary artery (LAD) and regional ventricular dysfunction (group 1, non-occluded LAD; group 2, occluded LAD) who underwent dobutamine echocardiography.
  
  
  METHODS
  26 patients underwent coronary artery bypass grafting and 27 had percutaneous transluminal coronary angioplasty.
  
  
  METHODS
  Baseline studies before revascularisation included cross sectional echocardiography at rest and during dobutamine infusion (5-10 microgram), and coronary angiography. The dobutamine study was performed mean (SD) 35 (28) days before revascularisation. Echocardiography at rest was repeated 90 (48) days after revascularisation.
  
  
  RESULTS
  Of 296 dysfunctional segments, 63 in group 1 (43%; 63/146) and 69 in group 2 (46%; 69/150) (NS) improved at follow up. Mean (SD) regional wall motion score index decreased from 1.97 (0.48) (95% confidence interval (CI) 1.01 to 2.93) before revascularisation to 1.74 (0.52) (95% CI 0.70 to 2.78) at follow up in group 1 (p = 0.001), and from 2.12 (0.41) (95% CI 1.30 to 2.98) to 1.88 (0.36) (95% CI 1.16 to 2.60) in group 2 (p = 0.0006). In group 1, sensitivity (87% v 52%; p < 0.0001), negative predictive value (88% v 65%; p = 0.001), and accuracy (77% v 64%; p = 0.01) were all significantly higher than in group 2, despite the angiographic evidence of collaterals in patients with occluded vessels.
  
  
  CONCLUSIONS
  Dobutamine echocardiography shows reduced sensitivity in predicting recovery of dysfunctional myocardium supplied by totally occluded vessels. Thus caution should be used in selecting such patients for revascularisation on the basis of a viability assessment made in this way.
authors.affiliation: Division of Cardiology, Federico II University, Via Sergio Pansini 5, I-80131 Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Piscione
authors.forename: P
authors.initials: P
authors.lastname: Perrone-Filardi
authors.forename: G
authors.initials: G
authors.lastname: De Luca
authors.forename: M
authors.initials: M
authors.lastname: Prastaro
authors.forename: C
authors.initials: C
authors.lastname: Indolfi
authors.forename: P
authors.initials: P
authors.lastname: Golino
authors.forename: S
authors.initials: S
authors.lastname: Dellegrottaglie
authors.forename: M
authors.initials: M
authors.lastname: Chiariello
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D017023:Coronary Angiography / Q000379:methods; D001026:Coronary Artery Bypass / Q000379:methods; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000534:rehabilitation / Q000601:surgery*; D004280:Dobutamine / Q000008:administration & dosage*; D025401:Echocardiography, Stress / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*; D011446:Prospective Studies; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D002316:Cardiotonic Agents; D013794:Thallium Radioisotopes; D004280:Dobutamine