Dynamics of structural and functional changes in hepatocyte mitochondria of senescence-accelerated OXYS rats.
Electron microscopy showed signs of degenerative dystrophic changes in hepatocytes and structural decompensation of mitochondria in senescence-accelerated OXYS rats in comparison with Wistar rats. These signs were detected in the presence of liver mitochondria dysfunction in OXYS rats: reduced oxygen consumption rate in all metabolic states, respiratory control volume, ADP/O ratio. transmembrane potential, and phosphorylation rate. The revealed disorders in mitochondrial structure and function are the key factors in the pathogenesis of accelerated aging in OXYS rats and visceropathies characteristic of these animals.
Kolosova
N G
NG
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Medical Sciences. pathol@cyber.ma.nsc.ru
Aidagulova
S V
SV
Nepomnyashchikh
G I
GI
Shabalina
I G
IG
Shalbueva
N I
NI
D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism; D022781:Hepatocytes / Q000502:physiology / Q000648:ultrastructure*; D007700:Kinetics; D008297:Male; D008564:Membrane Potentials; D008930:Mitochondria, Liver / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure*; D010085:Oxidative Phosphorylation; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar
D000255:Adenosine Triphosphate; D010100:Oxygen