The aetiology of idiopathic Parkinson's disease.
Agents potentially involved in the aetiology of idiopathic Parkinson's disease are discussed. These include factors regulating dopaminergic neurogenesis (Nurr 1, Ptx-3, and Lmx1b) and related proteins, together with genes involved in familial Parkinson's disease (alpha synuclein, parkin, and ubiquitin carboxy terminal hydroxylase L1), and endogenous and environmental agents.
Ramsden
D B
DB
Department of Medicine, Division of Medical Science, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK. D.B.Ramsden@bham.ac.uk
Parsons
R B
RB
Ho
S L
SL
Waring
R H
RH
D000818:Animals; D001921:Brain / Q000378:metabolism; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism; D050558:Cysteine Dioxygenase; D049308:Dioxygenases; D004298:Dopamine / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D060850:LIM-Homeodomain Proteins; D023421:Models, Animal; D009154:Mutation; D009474:Neurons / Q000502:physiology; D009498:Neurotoxins / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism; D010300:Parkinson Disease / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D000683:Serum Amyloid P-Component / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors; D016335:Zinc Fingers / Q000502:physiology; D000099153:Pentraxins
D002097:C-Reactive Protein; D050558:Cysteine Dioxygenase; D049308:Dioxygenases; D004298:Dopamine; D018398:Homeodomain Proteins; D060850:LIM-Homeodomain Proteins; D009498:Neurotoxins; D010105:Oxygenases; D000683:Serum Amyloid P-Component; D014157:Transcription Factors; D000099153:Pentraxins; C112149:LIM homeobox transcription factor 1 beta