[The experimental study of Sr-HAP on reconstructing mandibular bone defect].
OBJECTIVE
Different ration of Sr-HAP was implanted in animals to study the bioreactions in order to prepare for the clinical applications in future.


METHODS
24 rabbits were divided into 3 groups for study. Bone defect of 6 mm x 12 mm x 4 mm was made at the mandibular angle of rabbits and Sr-HAP of different proportion (10%, 5%, 0%) was applied to reform the defect. One group of animals were killed at 1 month, 3 months, 6 months to evaluate the biologic capacity with anatomy, histology, SEM, tetracycline fluorescent marker, ECT and ration histology.


RESULTS
Sr-HAP had hardly been rejected by hosts, and in early period after operation the new bone in the Sr-HAP was found with great quantities as the degradation of Sr-HAP much more than that in the pure HA, and the difference of bone quantity can be shown in statistics.


CONCLUSIONS
1. Sr-HAP has a better biocompatibility, biodegradation than pure HA and a excellent osteoinductivity. The existence of Sr-HAP improves the total new bone quantity and the interface of bone, also prolongs the period of new bone increasing. 2. Sr-HAP has a good biodegradation and suitable speed of biodegradating, so the reconstruction effect with Sr-HAP is fairly satisfactory.
Gu
Y
Y
Department of Oral Maxillofacial Surgery, Tongji Hospital, Affiliated Tongji University, Shanghai 200011, China.
Liao
D
D
Zhou
Z
Z
D000818:Animals; D001031:Apatites / Q000494:pharmacology*; D005147:Facial Bones / Q000002:abnormalities / Q000187:drug effects*; D020007:Implants, Experimental; D008334:Mandible / Q000002:abnormalities / Q000187:drug effects* / Q000378:metabolism; D008341:Mandibular Prosthesis; D023421:Models, Animal; D011817:Rabbits; D013324:Strontium / Q000737:chemistry / Q000494:pharmacology
D001031:Apatites; D013324:Strontium