title: Intra-aneurysmal pressure after incomplete endovascular exclusion.
abstract: OBJECTIVE
  An endoleak results from the incomplete endovascular exclusion of an aneurysm. We developed an experimental model to analyze hemodynamic changes within the aneurysm sac in the presence of an endoleak, with and without a simulated open collateral branch.
  
  
  METHODS
  With a latex aneurysm model connected to a pulsatile pump, pressures were measured simultaneously within the system (systemic pressure) and the aneurysm sac (intrasac pressure). The experiments were performed without endoleak (control group) and after creating a 3.5-mm (group 1), 4.5-mm (group 2), and 6-mm (group 3) diameter orifice in the endograft, simulating an endoleak. Pressures were also registered with and without a patent aneurysm side branch.
  
  
  RESULTS
  In each endoleak group, the intrasac diastolic pressure (DP) and mean pressure (MP) were significantly higher than the systemic DP and MP (P =.01, P =.006, and P =.001, respectively), although the pressure curve was damped. The presence of an open side branch significantly reduced the intrasac DP and MP.
  
  
  CONCLUSIONS
  In this model, intrasac pressures were significantly higher than systemic pressures in the presence of all endoleaks, even the smallest ones. Intrasac pressures higher than systemic pressure may pose a high risk for aneurysm rupture. Although patent side branches significantly reduce these pressures, the aggressive management of an endoleak should be pursued.
authors.affiliation: Service of Vascular Surgery, Instituto Cardiovascular de Buenos Aires, Argentina.
authors.forename: J C
authors.initials: JC
authors.lastname: Parodi
authors.forename: R
authors.initials: R
authors.lastname: Berguer
authors.forename: L M
authors.initials: LM
authors.lastname: Ferreira
authors.forename: R
authors.initials: R
authors.lastname: La Mura
authors.forename: M L
authors.initials: ML
authors.lastname: Schermerhorn
mesh_terms: D000783:Aneurysm / Q000503:physiopathology* / Q000601:surgery; D017542:Aneurysm, Ruptured / Q000209:etiology; D019917:Blood Vessel Prosthesis Implantation; D006801:Humans; D008955:Models, Cardiovascular; D011183:Postoperative Complications / Q000209:etiology; D011312:Pressure