Neuronal potential and lineage determination by neural stem cells.
How do neural stem cells ensure that they give rise to the right number and type of neurons at the right time? Over the past year several regulatory mechanisms have been identified, including promotion of neurogenesis by proneural bHLH genes, instruction of gliogenesis by Notch, and cell-intrinsic changes in the neurogenic capacity of stem cells in culture and in vivo.
Morrison
S J
SJ
Howard Hughes Medical Institute, Department of Internal Medicine, 3215 CCGC, University of Michigan, Ann Arbor, MI 48109-0934, USA. seanjm@umich.edu
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D009414:Nerve Growth Factors / Q000502:physiology; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051880:Receptors, Notch; D013234:Stem Cells / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology
D008565:Membrane Proteins; D009414:Nerve Growth Factors; D051880:Receptors, Notch; D014157:Transcription Factors