title: Efficacy of moxidectin 1% injectable against natural infection of Sarcoptes scabiei in sheep.
abstract: Thirty ewes naturally infected with Sarcoptes scabiei var. ovis, were allocated into three groups of 10 animals each. Animals in groups B and C were treated on day 0 and on days 0 and +10, respectively, with moxidectin 1% injectable at a dose of 0.2mg moxidectin/kg body weight (BW). Group A remained untreated. Seven days before treatment, the geometric mean of Sarcoptes scabiei var. ovis per square centimeter of skin in groups A, B and C were not significantly different. From the day of treatment to the end of the trial, the average number of mites/cm(2) increased in untreated animals and decreased in groups B and C, but these values were higher for group C. Active lesions produced by S. scabiei var. ovis consistently increased during the trial in the untreated animals; in group B the minimum count occurred on day +56 this reduction being more evident in group C (no lesions on days +49 and +56). Also in this group, the number of cured animals was 100%, therefore, the application of two treatments with moxidectin (group C) showed higher efficacy than a single treatment (group B). Body condition score decreased in the three experimental groups along the trial. All animals were individually weighed on days -1, +28 and at the end of the trial. No adverse reactions were observed in the animals treated with 0.2mg moxidectin/kg BW.
authors.affiliation: Departamento de Patología Animal (Sanidad Animal), Facultad de Veterinaria, Campus de Vegazana, Universidad de León, 24071 León, Spain. dsamha@isidoro.unileon.es
authors.forename: M R
authors.initials: MR
authors.lastname: Hidalgo Argüello
authors.forename: N
authors.initials: N
authors.lastname: Díez-Baños
authors.forename: B
authors.initials: B
authors.lastname: Martínez-González
authors.forename: F A
authors.initials: FA
authors.lastname: Rojo-Vázquez
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D018942:Macrolides; D012449:Safety; D012520:Sarcoptes scabiei / Q000254:growth & development; D012532:Scabies / Q000188:drug therapy / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D012867:Skin / Q000469:parasitology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D007306:Insecticides; D018942:Macrolides; C027837:moxidectin