Bagremycin A and B, novel antibiotics from streptomyces sp. Tü 4128.
Two novel secondary metabolites, bagremycin A (2) and B (3), were detected in the culture filtrate of Streptomyces sp. Tü 4128 by HPLC-diode-array screening. They are phenol esters of 3-amino-4-hydroxybenzoic acid with a derivative of p-coumaric acid and show a moderate activity against gram-positive bacteria and some fungi.
Bertasso
M
M
Mikrobiologisches Institut, Universität Tübingen, Germany.
Holzenkämpfer
M
M
Zeeck
A
A
Dall'Antonia
F
F
Fiedler
H P
HP
D062365:Aminobenzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005658:Fungi / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000145:classification / Q000254:growth & development / Q000378:metabolism*
D062365:Aminobenzoates; D000900:Anti-Bacterial Agents; C440631:bagremycin A; C440632:bagremycin B