Effects of soybean fibers on blood sugar, lipid levels and hepatic-nephritic histomorphology in mice with diabetes mellitus.
OBJECTIVE
To study the influence of soybean fibers on blood sugar, blood-lipid metabolism, and histomorphology in mice models with diabetes mellitus (DM).


METHODS
After normal mice and mice with Streptozocin (STZ)-induced DM were fed with forage containing a certain amount of soybean fiber (SF) for 5 weeks, blood sugar and blood lipid were determined, and morphological changes of hepatic and nephritic tissues were observed.


RESULTS
The results of 5-week experiment had shown: 1. In normal mice fed with SF, the blood sugar level was decreased (P < 0.05). There were no obvious changes in serum total cholesterol (TC) and the triglyceride (TG). The high-density-lipoprotein cholesterol (HDL-C) level was increased significantly (P < 0.05); 2. Among DM mice, blood sugar was decreased considerably (P < 0.001), TC and TG also decreased noticeably (P < 0.05), HDL-C increased clearly (P < 0.05); 3. SF has a protective role to the liver and kidney of DM mice.


CONCLUSIONS
It is suggested that SF has the function of decreasing blood sugar, blood-lipid and improving their metabolism, and of protecting liver and kidney of DM mice.
Xu
H
H
Jinan Military General Hospital, Jinan 250031, China.
Tan
S M
SM
Li
S Q
SQ
D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000503:physiopathology / Q000628:therapy*; D004043:Dietary Fiber; D004195:Disease Models, Animal; D007668:Kidney / Q000473:pathology; D050356:Lipid Metabolism; D008099:Liver / Q000473:pathology; D051379:Mice; D013025:Glycine max; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004043:Dietary Fiber; D014280:Triglycerides; D002784:Cholesterol