HSP70 stress proteins, nitric oxide, and resistance of August and Wistar rats to myocardial infarction.
Accumulation of HSP70 stress proteins in the myocardium and blood content of nitrite/nitrate in August rats with modeled myocardial infarction surpassed these parameters in Wistar rats less resistant to cardiovascular disorders by 2-2.5 and 1.8 times, respectively. Our results suggest that various resistance of August and Wistar rats to myocardial infarction is related to genetically determined differences in the activity of HSP70 and nitric oxide systems.
Pshennikova
M G
MG
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. 4909.g23@g23.relcom.ru
Belkina
L M
LM
Bakhtina
L Y
LY
Baida
L A
LA
Smirin
B V
BV
Malyshev
I Y
IY
D000818:Animals; D020022:Genetic Predisposition to Disease; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics* / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000096:biosynthesis / Q000378:metabolism*; D009573:Nitrites / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013045:Species Specificity
D018840:HSP70 Heat-Shock Proteins; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide