A novel dicyclodextrinyl ditelluride compound with antioxidant activity.
Reactive oxygen species (ROS) primarily arise from products of normal metabolic activities and are thought to be the etiology of many diseases. A novel dicyclodextrinyl ditelluride (2-TeCD) compound was designed to be a functional mimic of the glutathione peroxidase that normally removes ROS. 2-TeCD exhibited highly catalytic efficiency and good water solubility. Antioxidant activity was studied by using ferrous sulfate/ascorbate-induced mitochondria damage model system. 2-TeCD protected the mitochondria against oxidative damage in a dose-dependent manner and exhibited also great antioxidant ability in comparison with 2-phenyl-1,2-benziososelenazol-3(2H)-one. The mimic may result in better clinical therapies for the treatment of ROS-mediated diseases.
Ren
X
X
Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, China.
Xue
Y
Y
Zhang
K
K
Liu
J
J
Luo
G
G
Zheng
J
J
Mu
Y
Y
Shen
J
J
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D002417:Cattle; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005979:Glutathione Peroxidase / Q000737:chemistry / Q000378:metabolism; D054833:Isoindoles; D009682:Magnetic Resonance Spectroscopy; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D016566:Organoselenium Compounds / Q000494:pharmacology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D012995:Solubility
D000975:Antioxidants; D001393:Azoles; D003505:Cyclodextrins; D054833:Isoindoles; D009942:Organometallic Compounds; D016566:Organoselenium Compounds; D017382:Reactive Oxygen Species; C442326:dicyclodextrinyl ditelluride; C042986:ebselen; D005979:Glutathione Peroxidase