title: Pharmacological management of acute myocardial infarction in the municipal district of Rio de Janeiro.
abstract: BACKGROUND
  International studies have shown a large variation in the utilization patterns of interventions, in acute myocardial infarction.
  
  
  OBJECTIVE
  To analyze utilization patterns of pharmacological interventions in acute myocardial infarction and their corresponding effects on hospital mortality.
  
  
  METHODS
  Cross-sectional study. LOCAL: Hospitals of the Brazilian National Health System (SUS) in the municipal district of Rio de Janeiro.
  
  
  METHODS
  A stratified hospital sample of 391 medical records selected from the 1,936 admissions registered in the SUS Hospital Information System (SIH/SUS) with a main diagnosis of acute myocardial infarction, in the studied district in 1997.
  
  
  METHODS
  Sex, age, time to treatment, risk factors, severity factors, diagnosis confirmation, use of pharmacological interventions, hospital death, contraindication of the use of thrombolytic therapy, contraindication of aspirin use.
  
  
  RESULTS
  We reviewed 98.2% of the sampled medical records. Acute myocardial infarction diagnosis was confirmed in 91.7% (95% CI 88.3 to 94.2). 61.5% were men and 38.5% women, with an average age of 60.2 years (SD 2.4). The median time interval between symptom onset and hospital admission was 11 hours. Hospital mortality was 20.6% (95% CI 16.7 to 25.0). Intravenous thrombolytic therapy was used in 19.5% (95% CI 15.8 to 23.9) of the cases; aspirin in 86.5% (95% CI 82.5 to 89.6); beta-blockers in 49.0% (95% CI 43.8 to 54.1); angiotensin-converting enzyme (ACE) inhibitors in 63.3% (95% CI 58.2 to 68.1); nitrates in 82.0% (95% CI 82.4 to 89.6); heparin in 81.3% (95% CI 76.9 to 85.0); calcium antagonists in 30.5% (95% CI 26.0 to 35.4). There was a significant variation in the use of thrombolytic therapy, beta-blockers, ACE inhibitors, calcium antagonists and heparin among hospitals of different juridical nature.
  
  
  CONCLUSIONS
  There was underutilization of some interventions with well-established efficacy (thrombolytic therapy, aspirin, beta-blockers and intravenous nitrates). The use of calcium antagonists, not supported by scientific evidence in acute myocardial infarction, was quite frequent. A logistic model documented the benefit of aspirin, beta-blockers and ACE inhibitor use in reducing the chance of hospital death.
authors.affiliation: Epidemiology Service, Hospital dos Servidores do Estado, Ministry of Health, Rio de Janeiro, Brazil. cescosteguy@hse.saude.gov.br
authors.forename: C C
authors.initials: CC
authors.lastname: Escosteguy
authors.forename: M C
authors.initials: MC
authors.lastname: Portela
authors.forename: M T
authors.initials: MT
authors.lastname: Leite de Vasconcellos
authors.forename: R
authors.initials: R
authors.lastname: de Andrade Medronho
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001938:Brazil / Q000453:epidemiology; D000075202:Contraindications; D003430:Cross-Sectional Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D015912:Thrombolytic Therapy
chemical_list: D005343:Fibrinolytic Agents