[In vitro testing for drug resistance and drug sensitivity in clinical oncology].
In vitro methods for testing chemosensitivity and chemoresistance can contribute considerably to more individual chemotherapy of a given patient. Different tests which reflect with a different reliability and specificity the probable ineffectiveness of chemotherapy can be divided into several categories: 1. Indirect tests associated with general biological activity of the tumour. 2. Tests based on the specific relationship to a certain cytostatic. 3. Examination of hormonal receptors. 4. Direct tests based on testing of the sensitivity or resistance of a tumour to different cytostatics in primocultures or stabilized cultures. The submitted review presents information on different methods.
Kiss
I
I
Univerzitní onkologické centrum, oddĕlení klinické onkologie FN Brno, pracovistĕ Bohunice.
Zaloudík
J
J
Vyzula
R
R
Tomásek
J
J
Maláska
J
J
Coufal
O
O
Kocáková
I
I
D000818:Animals; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D014407:Tumor Cells, Cultured / Q000187:drug effects