Cell motility: ARNOand ARF6 at the cutting edge.
The transition of epithelial cells from a stationary to a motile state is important in embryogenesis, wound repair and metastasis. Recent studies have shown that ARNO and ARF6 play significant roles in coordinating this transition, providing new insight into the interplay between the Rho and ARF families of GTPases.
Turner
C E
CE
Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA. Turnerce@upstate.edu
Brown
M C
MC
D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors / Q000378:metabolism*; D002465:Cell Movement; D004847:Epithelial Cells / Q000502:physiology*; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D008954:Models, Biological; D009024:Morphogenesis; D009362:Neoplasm Metastasis; D014945:Wound Healing
D000089982:ADP-Ribosylation Factor 6; D020690:GTPase-Activating Proteins; C102474:cytohesin-2; D020727:ADP-Ribosylation Factors