The role of acidic fibroblast growth factor in recovery of acoustic trauma.
We administered acidic fibroblast growth factor (aFGF) to the perilymph of the guinea pig cochlea after exposure to intense sound to investigate its effect on the process of recovery after acoustic trauma. We assessed auditory brain stem response (ABR) thresholds to evaluate cochlear function and observed the sensory epithelium using confocal laser-scanning microscopy. After noise exposure (120 dB SPL, 5 h), the ABR threshold showed an increase of approximately 50 dB SPL that recovered after 14 days. Cochlear function in aFGF treated ears recovered more quickly than that in control ears. These results suggest that aFGF may play an important role in cochlear recovery after acoustic injury.
Sugahara
K
K
Department of Otolaryngology, Yamaguchi University School of Medicine, Minamikogushi 1-1-1, Ube, Yamaguchi, Japan.
Shimogori
H
H
Yamashita
H
H
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology; D003051:Cochlea / Q000166:cytology / Q000187:drug effects* / Q000293:injuries; D015834:Cochlear Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D007839:Functional Laterality / Q000502:physiology; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D015918:Infusion Pumps, Implantable; D018613:Microscopy, Confocal; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009925:Organ of Corti / Q000166:cytology / Q000187:drug effects / Q000293:injuries; D020127:Recovery of Function / Q000187:drug effects* / Q000502:physiology; D013016:Sound / Q000009:adverse effects*; D016896:Treatment Outcome
D018696:Neuroprotective Agents; D005346:Fibroblast Growth Factors