Heat shock protein expression and immunity: relevance to gynecologic oncology.
Heat shock proteins function as molecular chaperones, guiding the transport, assembly and degradation of intracellular polypeptides. Under the influence of non-physiological conditions heat shock protein synthesis is accelerated to aid cell survival. Thus, over-production of heat shock proteins protects malignantly transformed cells from apoptotic cell death and fosters resistance to chemotherapeutic agents and irradiation. Individual heat shock proteins, such as the 27 kDa (hsp27) and 70 kDa (hsp70) heat shock proteins, their antibodies and/or genotypes of polymorphic genes may have diagnostic and prognostic value for different gynecologic malignancies. The possible exploitation of the properties of heat shock proteins for development of unique anti-cancer therapies in individuals resistant to traditional treatment is currently under active investigation.
Witkin
S S
SS
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University New York, New York 10021, USA.
D000951:Antigens, Neoplasm / Q000378:metabolism; D001323:Autoantibodies / Q000032:analysis; D001943:Breast Neoplasms / Q000276:immunology / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D016889:Endometrial Neoplasms / Q000276:immunology / Q000378:metabolism; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality; D011110:Polymorphism, Genetic; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000378:metabolism
D000951:Antigens, Neoplasm; D001323:Autoantibodies; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; C052646:sarcoma glycoprotein gp96 rejection antigens