title: Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins.
abstract: We present here a series of high-density maps of single-nucleotide polymorphisms (SNPs) detected in genes encoding three organic-anion transporters, three organic anion-transporting polypeptides, and three nicotinamide adenine dinucleotide, reduced:ubiquinone oxidoreductase flavoproteins. A total of 258 SNPs were identified among these nine genes through systematic screening of DNA from 48 Japanese individuals: 17 in 5' flanking regions, three in 5' untranslated regions, 13 in coding regions, 211 in introns, six in 3' untranslated regions, and 8 in 3' flanking regions. By comparing our data with SNPs deposited in the dbSNP database in the National Center for Biotechnology Information, we determined that 236 (91.5%) were novel. In addition, 46 genetic variations of other types were discovered within these loci. These high-resolution maps will serve as a useful resource for analyzing potential associations between variations in these nine genes and differences in human susceptibilities to common diseases or response to drug therapies.
authors.affiliation: Laboratory for Genotyping. RIKEN SNP Research Center, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Iida
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: A
authors.initials: A
authors.lastname: Sekine
authors.forename: C
authors.initials: C
authors.lastname: Mishima
authors.forename: K
authors.initials: K
authors.lastname: Kondo
authors.forename: Y
authors.initials: Y
authors.lastname: Kitamura
authors.forename: S
authors.initials: S
authors.lastname: Harigae
authors.forename: S
authors.initials: S
authors.lastname: Osawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D002874:Chromosome Mapping; D004247:DNA / Q000097:blood / Q000302:isolation & purification; D042967:Electron Transport Complex I; D005091:Exons; D005420:Flavoproteins / Q000235:genetics; D006801:Humans; D007564:Japan; D027381:Liver-Specific Organic Anion Transporter 1 / Q000235:genetics*; D005810:Multigene Family; D009247:NADH, NADPH Oxidoreductases / Q000235:genetics*; D027361:Organic Anion Transporters / Q000235:genetics*; D029362:Organic Anion Transporters, Sodium-Independent; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D005420:Flavoproteins; D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; D029362:Organic Anion Transporters, Sodium-Independent; C427208:SLC22A10 protein, human; C427207:SLC22A11 protein, human; D004247:DNA; D009247:NADH, NADPH Oxidoreductases; D042967:Electron Transport Complex I