Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation.
A novel presenilin binding protein, PBP, has recently been identified. PBP is localized to the particulate fraction of extracts of Alzheimer's disease brain but is found in the soluble fractions of brain from age matched normal controls. It is shown here that PBP is associated with neurofibrillary tangles in Alzheimer's disease brain. In addition, the expression of PBP increases the phosphorylation of tau in cultured cells. Therefore PBP may have a regulatory role in tau phosphorylation and in the genesis of neurofibrillary tangles.
Chen
Q
Q
Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Yoshida
H
H
Schubert
D
D
Maher
P
P
Mallory
M
M
Masliah
E
E
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D001921:Brain / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002352:Carrier Proteins / Q000502:physiology*; D004789:Enzyme Activation / Q000502:physiology; D038362:Glycogen Synthase Kinase 3; D020662:Guanine Nucleotide Exchange Factors; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D010766:Phosphorylation; D012016:Reference Values; D016875:tau Proteins / Q000378:metabolism*
D002352:Carrier Proteins; C485840:DOCK3 protein, human; D020662:Guanine Nucleotide Exchange Factors; D009419:Nerve Tissue Proteins; D016875:tau Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D038362:Glycogen Synthase Kinase 3