Conformational rigidity introduced by 2',5'-phosphodiester links in DNA.
Conformational properties of 2',5'-linked 3'-deoxyribonucleotides have been compared with their natural isomer using CD spectroscopy. It is inferred from the salt induced titration curves that the 2',5'-linked-3'deoxyribonucleotides have rigid phosphodiester backbone.
Kumar
A
A
Division of Biopolymers, Central Drug Research Institute, Lucknow, India.
Dass
D
D
Atreyi
M
M
Rao
M V
MV
Katti
S B
SB
D001483:Base Sequence; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D011487:Protein Conformation; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013696:Temperature; D013816:Thermodynamics; D013873:Thionucleotides / Q000737:chemistry*; D014466:Ultraviolet Rays
D009841:Oligonucleotides; D010710:Phosphates; D011993:Recombinant Fusion Proteins; D013873:Thionucleotides; D004247:DNA