Detection of tumor-associated circulating mRNA in patients with disseminated malignant melanoma.
It has been suggested that extracellular mRNA might be released from tumor cells and might be protected from serum RNase by proteins or proteolipid complexes. Our group has recently assessed the potential value of extracellular RNA detection by RT-PCR in the peripheral blood of patients with metastatic melanoma.
Rappl
G
G
Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.
Hasselmann
D O
DO
Rössler
M
M
Ugurel
S
S
Tilgen
W
W
Reinhold
U
U
D000951:Antigens, Neoplasm; D006801:Humans; D058965:MART-1 Antigen; D008545:Melanoma / Q000097:blood* / Q000235:genetics / Q000473:pathology; D014442:Monophenol Monooxygenase / Q000235:genetics; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000235:genetics; D009360:Neoplastic Cells, Circulating; D012333:RNA, Messenger / Q000097:blood*; D012334:RNA, Neoplasm / Q000097:blood*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000951:Antigens, Neoplasm; D058965:MART-1 Antigen; C548667:MLANA protein, human; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D014442:Monophenol Monooxygenase