Allelic distribution of HLA-B*5 in HLA-B5-positive Israeli patients with Behçet's disease.
In order to investigate the sub-typing of the B5 antigen in Israeli (Jewish and Arabic) patients with Behçet's disease (BD) allele-specific genotyping of B51 and B52 alleles was performed in Israeli BD patients and healthy controls. Among the HLA-B51-positive BD patients, B*5101 was found to be the predominant allele, identified in 62% of all BD patients and 78% of Jewish BD patients. HLA-B*5101 was also the predominant allele in HLA-B51-positive healthy controls. HLA-B*5108 and B*5104 alleles were identified in 23% and 15% of B51-positive BD patients, respectively. The HLA-B*5201 allele was identified in all HLA-B52-positive patients and controls. Our study suggests that both HLA-B*5101 and HLA-B*5201 are the dominant alleles of HLA-B5 in Israeli BD patients.
Paul
M
M
Department of Medicine B, Rabin Medical Center, Beilinson Campus, Tel Aviv University, Tel Aviv, Israel.
Klein
T
T
Krause
I
I
Molad
Y
Y
Narinsky
R
R
Weinberger
A
A
D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics*; D005787:Gene Frequency; D005805:Genes, MHC Class I; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D059949:HLA-B51 Antigen; D059950:HLA-B52 Antigen; D006801:Humans; D007557:Israel
D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D059950:HLA-B52 Antigen