title: Treatment of acrodermatitis continua of Hallopeau with oral propylthiouracil and methotrexate.
abstract: A 71-year-old man with acrodermatitis continua of Hallopeau was treated successfully with a combination of oral propylthiouracil and methotrexate. After 14 weeks, he developed acute pancytopenia, an uncommon idiosyncratic side-effect of propylthiouracil, and presented with a life-threatening methicillin-resistant Staphylococcus aureus pneumonia. This illustrates the potential value and associated risks of propylthiouracil in the management of this difficult condition.
authors.affiliation: Department of Dermatology, Box 100, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK.
authors.forename: M M
authors.initials: MM
authors.lastname: Chowdhury
authors.forename: R J
authors.initials: RJ
authors.lastname: Motley
mesh_terms: D000169:Acrodermatitis / Q000150:complications / Q000188:drug therapy*; D000208:Acute Disease; D000368:Aged; D000963:Antimetabolites / Q000009:adverse effects / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D016106:Methicillin Resistance; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D010198:Pancytopenia / Q000139:chemically induced; D011023:Pneumonia, Staphylococcal / Q000150:complications; D011441:Propylthiouracil / Q000009:adverse effects / Q000627:therapeutic use*; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy*; D013211:Staphylococcus aureus
chemical_list: D000963:Antimetabolites; D011441:Propylthiouracil; D008727:Methotrexate