Effect of niprisan on single oral dose pharmacokinetics of paracetamol in rats.
The single oral dose pharmacokinetics of paracetamol was studied alone and after coadministration with NIPRISAN In rats. Paracetamol concentrations were measured in rat plasma using UV-spectrophotometer and the data were fitted into an open two-compartment pharmacokinetic model using the computer program (STATIS Version 3.0). Results indicated no significant difference in the absorption of paracetamol between study and control groups but a significant reduction (p < 0.05) at some sampling time as the dose of NIPRISAN was increased double-fold. The pharmacokinetic parameters showed only 1.51 and 7.19% reduction in AUC(0-infinity) and Cmax respectively for paracetamol (20 mg/kg) + NIPRISAN (500 mg/kg). It was thus concluded that the gastric presence of NIPRISAN did not significantly reduce the absorption of paracetamol in rats.
Adzu
B
B
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Garki, Abuja, Nigeria.
Garba
M
M
Haruna
A
A
Maman
M
M
Wambebe
C
C
Gamaniel
K
K
D000082:Acetaminophen / Q000493:pharmacokinetics*; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics*; D000818:Animals; D000986:Antisickling Agents / Q000494:pharmacology*; D019540:Area Under Curve; D004347:Drug Interactions; D007202:Indicators and Reagents; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D000986:Antisickling Agents; D007202:Indicators and Reagents; C445122:Niprisan; D010936:Plant Extracts; D000082:Acetaminophen