Molecular biology of lung cancer.
Lung cancer develops slowly over many years from the sequential accumulation of gene alterations in susceptible pulmonary cells. The global epidemic of tobacco addiction has accelerated the incidence of lung cancer and has now focused increased attention on this disease worldwide. This review will briefly outline some of the tumor suppressor gene pathways that are known or suspected to play an important role in the development of this deadly malignancy.
Kaye
F J
FJ
Genetics Branch, Center for Cancer Research, National Cancer Institute-Navy Oncology and National Naval Medical Center, Naval Hospital, Building 8/Room 5105, Bethesda, MD 20889, USA. fkaye@helix.nih.com
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000503:physiopathology*; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000503:physiopathology*; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D018570:Risk Assessment; D012907:Smoking / Q000009:adverse effects