Effect of acetaminophen on atherosclerosis.
OBJECTIVE
To evaluate the antioxidant effects of acetaminophen in atherosclerosis.


METHODS
Experimental literature and abstracts accessed through MEDLINE (1966-February 2001).


RESULTS
Atherosclerosis is an inflammatory disorder associated with coronary events. The oxidative stress burden resulting from excess pro-oxidant free radical formation contributes to oxidative modification of low-density lipoprotein (lipid peroxidation) and is associated with atherosclerosis. Acetaminophen (phenol-like compound) may limit these key processes that are involved. The findings of earlier experimental laboratory tests and abstracts are evaluated.


CONCLUSIONS
In vitro data suggest that acetaminophen may reduce lipid peroxidation, whereas animal data showed decreased progression of atherosclerosis. Further animal model and human studies are required to confirm these earlier findings.
Chong
P H
PH
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, USA. cpang@tigger.cc.uic.edu
Kezele
B
B
Pontikes
P J
PJ
D000082:Acetaminophen / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen