Intrathecal clonidine for controlling spastic hypertonia.
Intrathecal clonidine is a powerful antispastic drug. Its mechanism of action is more selective than baclofen. The acute effects are reviewed. An assessment of side effects of clonidine during chronic infusion is needed.
Rémy-Néris
O
O
Department of Physical Medicine and Rehabilitation, Hopital Raymond Poinçaré Garches, France.
Denys
P
P
Bussel
B
B
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007278:Injections, Spinal; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D012026:Reflex, Stretch / Q000187:drug effects; D013119:Spinal Cord Injuries / Q000150:complications
D000316:Adrenergic alpha-Agonists; D003000:Clonidine