title: In silico screening for tumour-specific expressed sequences in human genome.
abstract: A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression.
authors.affiliation: Vavilov Institute of General Genetics, 3 Gubkina Str., Moscow 119991, Russia. baranova@vigg.ru
authors.forename: A V
authors.initials: AV
authors.lastname: Baranova
authors.forename: A V
authors.initials: AV
authors.lastname: Lobashev
authors.forename: D V
authors.initials: DV
authors.lastname: Ivanov
authors.forename: L L
authors.initials: LL
authors.lastname: Krukovskaya
authors.forename: N K
authors.initials: NK
authors.lastname: Yankovsky
authors.forename: A P
authors.initials: AP
authors.lastname: Kozlov
mesh_terms: D030541:Databases, Genetic; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling / Q000379:methods*; D015723:Gene Library; D052138:Genes, Neoplasm; D015894:Genome, Human; D006801:Humans; D009369:Neoplasms / Q000235:genetics*