Four novel withanolide-type steroids from the leaves of Solanum cilistum.
Four novel withanolide-type steroids named cilistols p, pm, p1 and u (1-4, respectively), were isolated from the leaves of Solanum cilistum. The respective structures were characterized by spectroscopic means as follows: cilistol p (1) was (22R,24R,25R,26S)-1-oxo-22,26-epoxy-3alpha,5alpha-cycloergostane-6beta,17alpha, 24,25,26-pentaol 26-O-beta-D-glucopyranoside, cilistol pm (2) corresponded to the 6-O-methyl ether derivative of 1; cilistol p1 (3) was represented as the 24-O-methyl ether of 1, and cilistol u (4) was shown to be the epoxide between C-24 and -25, presumably bearing cilistols p, pm and p1 by ring-opening.
Zhu
X H
XH
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Ando
J
J
Takagi
M
M
Ikeda
T
T
Yoshimitsu
A
A
Nohara
T
T
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D004187:Disaccharides / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D012991:Solanaceous Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification; D014312:Trisaccharides / Q000737:chemistry* / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D004187:Disaccharides; D006027:Glycosides; D007783:Lactones; D010936:Plant Extracts; D012991:Solanaceous Alkaloids; D013256:Steroids; D014312:Trisaccharides