title: Quality of life after balloon angioplasty or stenting for acute myocardial infarction. One-year results from the Stent-PAMI trial.
abstract: OBJECTIVE
  The goal of this study was to compare the impact of primary stenting or percutaneous transluminal coronary angioplasty (PTCA) on health-related quality of life (HRQOL) in patients undergoing direct angioplasty for acute myocardial infarction (AMI).
  
  
  BACKGROUND
  Previous studies have demonstrated that coronary stenting reduces clinical and angiographic restenosis compared with PTCA. However, the impact of stenting on HRQOL from the patient's perspective remains unknown.
  
  
  METHODS
  We administered the Seattle Angina Questionnaire and the Medical Outcomes Study Short-form Survey at 1, 6 and 12 months after initial treatment to all North American patients in the Stent-Primary Angioplasty for Myocardial Infarction trial (Stent-PAMI) (n = 509)-a randomized trial comparing primary stenting to conventional PTCA for patients with AMI.
  
  
  RESULTS
  At one month, most HRQOL measures were similar for the two groups, but stent patients reported less bodily pain than PTCA patients (p = 0.03). At six-month follow-up, stenting resulted in significant improvements in several dimensions of HRQOL including reduced anginal frequency and bodily pain as well as improved disease perception (all p < or = 0.03) and a trend towards better anginal stability (p = 0.056). By 12-month follow-up, however, none of these differences remained statistically significant. These differences in HRQOL were largely explained by the greater need for ischemia-driven target-vessel repeat revascularization procedures in PTCA patients during the first six months (16.0% vs. 6.2%, p < 0.001).
  
  
  CONCLUSIONS
  In patients undergoing revascularization for AMI, initial stent placement is associated with improvements in several dimensions of health status during the first six months of follow-up. In the absence of differences in mortality, these findings add to the overall argument in favor of initial stenting in patients treated with mechanical reperfusion for myocardial infarction.
authors.affiliation: Cardiovascular Data Analysis Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rinfret
authors.forename: C L
authors.initials: CL
authors.lastname: Grines
authors.forename: R S
authors.initials: RS
authors.lastname: Cosgrove
authors.forename: K K
authors.initials: KK
authors.lastname: Ho
authors.forename: D A
authors.initials: DA
authors.lastname: Cox
authors.forename: B R
authors.initials: BR
authors.lastname: Brodie
authors.forename: M C
authors.initials: MC
authors.lastname: Morice
authors.forename: G W
authors.initials: GW
authors.lastname: Stone
authors.forename: D J
authors.initials: DJ
authors.lastname: Cohen
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality / Q000628:therapy*; D010147:Pain Measurement; D011788:Quality of Life; D015607:Stents; D011795:Surveys and Questionnaires; D016896:Treatment Outcome