[Comparative immunologic activity of marine bioglycans].
Immunomodulating activity of three marine bioglycanes of different structure was investigated. The following preparations were compared: mitilan--glycoprotein, containing 1,4-alpha-D-glucane, isolated from mussel Crenomytilus grayanus; translam--beta-1,3; 1,6-beta-D-glucane isolated from Laminaria cichorioides and zosterin--low-metoxylated pectine isolated from marine plant of genera Zosteraceae. It was shown that immune response modulating was due to delicate and complex interaction of immune competent cells with cytokins participation. All bioglycanes investigated when introduced into animals organism produced changes in immune system: spleen mass enlarged, lymphocytes subpopulation redistributed, nonspecific T-supressors activity enhanced, content of interferone in blood serum increased. It is considered that similarity of immune system reactions is due to polysaccharide component of investigated biopolymers and potency of the effect is determined by structural specificity and by stereochemistry of each bioglycane.
Zaporozhets
T S
TS
Research Institute of Epidemiology and Microbiology, Siberian Branch of the Russian Academy of Medical Sciences, Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok.
Besednova
N N
NN
Molchanova
V N
VN
Zviagintseva
T N
TN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D049872:Bivalvia; D005936:Glucans / Q000494:pharmacology*; D007371:Interferon-gamma / Q000378:metabolism; D007795:Laminaria; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009929:Organ Size; D011134:Polysaccharides / Q000494:pharmacology*; D017452:Receptors, IgG / Q000378:metabolism; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism
D000276:Adjuvants, Immunologic; D005936:Glucans; D011134:Polysaccharides; D017452:Receptors, IgG; C033671:epiglucan; C070927:zosterin; D007371:Interferon-gamma