Controlling malaria: challenges and solutions.
Antimalarial drug resistance is a major public health challenge and the principal reason for the erosion of efficacious treatments. Cost and the limited number of antimalarial drugs in current use impose considerable constraints on malaria control, especially in sub-Saharan Africa. The paper describes a multilateral, multidisciplinary research project on artemisinin-based combination therapy, which offers a new and potentially highly effective way to prevent or retard the development of drug resistance.
Olliaro
P
P
UNDP/World Bank/World Health Organization Special Program for Research & Training in Tropical Diseases (TDR), Geneva, Switzerland. olliarop@who.int
Taylor
W R
WR
Rigal
J
J
D026683:Advisory Committees; D017954:Africa South of the Sahara / Q000453:epidemiology; D000962:Antimalarials / Q000191:economics / Q000627:therapeutic use*; D037621:Artemisinins; D015415:Biomarkers; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D023381:Endpoint Determination; D015340:Epidemiologic Research Design; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000453:epidemiology; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic / Q000592:standards; D012717:Sesquiterpenes / Q000191:economics / Q000627:therapeutic use*; D016896:Treatment Outcome; D014944:World Health Organization
D000962:Antimalarials; D037621:Artemisinins; D015415:Biomarkers; D012717:Sesquiterpenes; C031327:artemisinin