Extractive-spectrophotometric determination of some 2- and 10-disubstituted phenothiazines with dipicrylamine.
Dipicrylamine reacts in neutral medium with some 2,10-disubstituted phenothiazines (promazine, chlorpromazine and promethazine hydrochlorides, trifluoperazine dihydrochloride, thioproperazine dimethanosulphonate) forming orange or brown ion-association compounds. The compounds are insoluble in water but quantitatively extracted into chloroform. These properties have been exploited for the determination of phenothiazines in pure solutions and pharmaceuticals.
Regulska
E
E
Department of Chemistry, Białystok Technical University, Poland.
Puzanowska-Tarasiewicz
H
H
D002138:Calibration; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D010640:Phenothiazines / Q000032:analysis*; D010851:Picrates / Q000737:chemistry*; D013607:Tablets
D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D010640:Phenothiazines; D010851:Picrates; D013607:Tablets; C011454:dipicrylamine