Effects of diabetes on creatine kinase activity in streptozotocin-diabetic rats.
OBJECTIVE
To study the effect of diabetes on the creatine kinase (CK) activity in different tissues of streptozotocin-induced diabetic rats.


METHODS
Serum samples, heart, extensor digitorum longus, brain and bladder were collected from both streptozotocin-induced diabetic rat and control group. Ck was measured by enzymologic method.


RESULTS
The body weight, heart weight and brain weight were reduced significantly compared with control group (P < 0.001), but bladder weight was increased significantly (P < 0.001). CK activity in serum and extensor digitorum longus in diabetic rat was significantly lower (P < 0.001); CK activity in diabetic heart was lower (P < 0.01); and in brain also lower (P < 0.05). A higher CK activity in diabetic bladder was found (P < 0.001).


CONCLUSIONS
Diabetes can result in a lower CK activity in serum, heart, brain and extensor digitorum longus that may affect the energy metabolism in the tissues. A higher CK activity in diabetic bladder may reflect a functional compensatory mechanism.
Zhao
X
X
Department of Laboratory Medicine, Beijing Hospital, Beijing 100730, China. linzhao@public.bta.net.cn
Bassirat
M
M
Zeinab
K
K
Helme
R D
RD
D000818:Animals; D001921:Brain / Q000201:enzymology; D003402:Creatine Kinase / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D001743:Urinary Bladder / Q000201:enzymology
D003402:Creatine Kinase