Murihexol, a linear acetogenin from Annona muricata.
Murihexol (1), a novel acetogenin, and three known ones, donhexocin (2), annonacin A and annonacin, have been isolated from the seeds of Annona muricata. Compound 1 is a C(35) acetogenin without any THF rings, with six hydroxyls in the long aliphatic chain. The hydroxyls of 1 and 2 are all located at C-4, C-10, C-15, C-16, C-19 and C-20, but their stereochemistries are different. The vicinal diol at C-15/C-16 in 1 is threo and C-19/C-20 has the erythro configuration; in 2 C-15/C-16 and C-19/C-20 all have the same threo configuration.
Yu
Jing Guang
JG
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, 100094, P.R., Beijing, China
Gui
Hua Qing
HQ
Luo
Xiu Zhen
XZ
Sun
Lan
L