Assessment of human cancer risk: challenges for alternative approaches.
The ILSI/HESI Workshop on Alternatives to Carcinogenicity Testing aims to develop and apply new methods for assessment of potential carcinogenic risk to humans from various chemicals. The Workshop represents a major cooperative scientific effort. The long-term goals should be to greatly enhance the efficiency and reliability of such testing and to supplant, not just supplement, lifetime rodent bioassays. There are now well-established frameworks for risk assessment and risk management, putting risks into public health context and engaging stakeholders. The Lave-Omenn value-of-information model provides a useful way to assess the social costs and benefits of different strategies for testing large numbers of chemicals.
Omenn
G S
GS
The University of Michigan, Ann Arbor 48109-0626, USA.
D000047:Academies and Institutes; D000826:Animal Testing Alternatives; D000818:Animals; D015197:Carcinogenicity Tests / Q000191:economics / Q000379:methods*; D002273:Carcinogens / Q000633:toxicity*; D003362:Cost-Benefit Analysis; D004493:Education; D006801:Humans; D007391:International Cooperation; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D018570:Risk Assessment / Q000191:economics / Q000379:methods
D002273:Carcinogens