Histaminergic regulation of smooth muscles in rabbit pulmonary arteries.
Histaminergic contractile reactions of smooth muscles in rabbit lobar pulmonary arteries were studied using in vitro mechanographic technique. Histamine via activation of H-receptors induced a dose-dependent constriction of smooth muscle segments, while endothelium inhibited histamine-induced contractile reactions. Histamine increased sensitivity of smooth muscle cells in pulmonary artery to sodium nitroprusside.
Kapilevich
L V
LV
Siberian State Medical University, Tomsk. kapil@aport.ru
Anfinogenova
Y D
YD
Nosarev
A V
AV
Baskakov
M B
MB
Kovalev
I V
IV
D'yakova
E Y
EY
Medvedev
M A
MA
D000818:Animals; D046508:Culture Techniques; D004155:Diphenhydramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D006632:Histamine / Q000494:pharmacology*; D007537:Isometric Contraction; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D013314:Stress, Mechanical; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D009599:Nitroprusside; D006632:Histamine; D004155:Diphenhydramine; D011188:Potassium