Study of the genotoxic potential of iron ions by the SOS chromotest.
Modulation of iron ions induced SOS response by scavengers of reactive oxygen species was studied in SOS chromotest in three strains of Escherichia coli (PQ37, PQ300 and OG400). Iron ions in the absence of reductants induced SOS response generated by reactive oxygen species in a dose dependent manner and this was inhibited in the presence of catalase.
Marczewska
J
J
Drug Institute, Warsaw, Poland.
Koziorowska
J H
JH
D004249:DNA Damage / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D007501:Iron / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*; D013055:Spectrophotometry, Infrared; D013482:Superoxide Dismutase / Q000032:analysis / Q000096:biosynthesis*
D009153:Mutagens; D007501:Iron; D013482:Superoxide Dismutase