Influence of bone environment on ceramic osteointegration in spinal fusion: comparison of bone-poor and bone-rich sites.
Quantitative experimental data showed differences in bone quality and ceramic incorporation between bone-rich and bone-poor implantation sites. Bone in-growth was significantly lower for ceramic implanted at a lumbar intertransverse than a laminar site. Bone-marrow enrichment of the lumbar intertransverse site (regarded as bone-poor) greatly facilitated ceramic osteointegration. The vertebral interbody site, despite theoretical richness in osteogenic precursor cells, might be bone-poor at the time of grafting as compared to the reference iliac crest site. These data have important clinical implications concerning the potential benefit of enriching both bone-poor and bone-rich sites.
Delécrin
J
J
Department of Orthopaedic Surgery, Hôtel Dieu, University Hospital of Nantes, France. joel.delecrin@chu-nantes.fr
Deschamps
C
C
Romih
M
M
Heymann
D
D
Passuti
N
N
D016026:Bone Marrow Transplantation; D001842:Bone and Bones / Q000503:physiopathology*; D002516:Ceramics; D006801:Humans; D016348:Osseointegration / Q000502:physiology*; D019736:Prostheses and Implants; D013123:Spinal Fusion; D013234:Stem Cells / Q000502:physiology