title: Aortic root dilatation in patients with emphysema.
abstract: BACKGROUND
  Abdominal aortic aneurysms have been recognized to occur more frequently in patients with emphysema. However, the prevalence of aortic root dilatation in patients with emphysema and its relationship to risk factors for aortic enlargement have not been previously described.
  
  
  METHODS
  We studied 47 patients, past smokers (aged 67 +/- 6 years, 18 women) with severe emphysema diagnosed by a pulmonary function test and an ultrafast computed tomographic scan. Two-dimensional echocardiography was used to measure the aortic root at the aortic annulus, sinus of Valsalva, sinotubular junction and proximal part of the ascending aorta. Measured mean values were compared with published normal values and age- and sex-matched patients without emphysema. The relationship between aortic root size and cardiac risk factors (hypertension, hypercholesterolemia, and diabetes) was also examined.
  
  
  RESULTS
  In patients with emphysema the mean aortic root dimensions were significantly larger than normal values at each measured site (P <.0001) and those of patients without emphysema (P <.05 to.0001). A substantial percentage of patients with emphysema had larger sinus of Valsalva (43%) and proximal ascending aorta (59%) than the upper limit of normal. In the multivariable regression model, emphysema was a significant determinant of aortic root size at all measured sites and hypertension was associated with additional dilatation at the sinus of Valsalva, sinotubular junction, and proximal ascending aorta.
  
  
  CONCLUSIONS
  (1) In patients with emphysema the aortic root dimension is significantly larger than in patients without emphysema. (2) Systemic hypertension is associated with additional enlargement of the proximal ascending aorta, the sinus of Valsalva, and the sinotubular junction.
authors.affiliation: Divisions of Cardiology and Pulmonary Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: A V
authors.initials: AV
authors.lastname: Brasch
authors.forename: Z
authors.initials: Z
authors.lastname: Mohsenifar
authors.forename: D S
authors.initials: DS
authors.lastname: Jeon
authors.forename: H
authors.initials: H
authors.lastname: Luo
authors.forename: J M
authors.initials: JM
authors.lastname: Mirocha
authors.forename: S S
authors.initials: SS
authors.lastname: Khan
authors.forename: R J
authors.initials: RJ
authors.lastname: Siegel
mesh_terms: D000368:Aged; D001018:Aortic Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging / Q000453:epidemiology; D004452:Echocardiography; D004646:Emphysema / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology