title: A 23Na NMR study of the effect of D(+) and L(-) arabitol on NaDNA in aqueous solution.
abstract: The 23Na NMR quadrupolar relaxation in NaDNA aqueous solutions has been investigated in the presence of D(+) and L(-) arabitol. Quite different results were produced by the enantiomers, i.e. the addition of D(+) arabitol produced a small increase of the 23Na NMR relaxation rates, while in the presence of L(-) arabitol a significant decrease was observed. These findings were analysed and discussed in terms of an effective interaction of L(-) arabitol with DNA.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Cagliari, Cittadella Universitaria di Monserrato, S.S. 554 09042 (CA), Monserrato, Italy.
authors.forename: F C
authors.initials: FC
authors.lastname: Marincola
authors.forename: M
authors.initials: M
authors.lastname: Casu
authors.forename: G
authors.initials: G
authors.lastname: Saba
authors.forename: A
authors.initials: A
authors.lastname: Lai
authors.forename: P
authors.initials: P
authors.lastname: del Vecchio
authors.forename: G
authors.initials: G
authors.lastname: Barone
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D009682:Magnetic Resonance Spectroscopy; D011485:Protein Binding; D012975:Sodium Isotopes; D013402:Sugar Alcohols / Q000737:chemistry*; D013950:Thymus Gland / Q000378:metabolism; D014867:Water / Q000737:chemistry*
chemical_list: D012975:Sodium Isotopes; D013402:Sugar Alcohols; D014867:Water; D004247:DNA; C014999:arabitol