[Effect of chemical sympathectomy on myoelectric activity of the small bowel].
Central and peripheral noradrenergic system modulates myoelectric activity of the small bowel. Aim of this study was to evaluate the role of peripheral noradrenergic system in modulation of slow waves activity. Recordings of slow waves were performed on 20 conscious rats chronically fitted with 2 unipolar electrodes. After controls recording the animals were injected i.p. with 6-hydroxydopamine (6-OHDA--Sigma H8523) and the recording were performed on daily basis through the period of one month.


RESULTS
The increase of frequency slow waves during the first week after 6-OHDA from 0.61 (+/- 0.11) to 0.71 (+/- 0.03), (p. < 0.05), and amplitude from 14468 +/- 11196 to 19128 +/- 5282 (microV)2 (p > 0.05) were observed. Variability in control recording was higher (SD +/- 0.11) than after 6-OHDA (SD 0.03). Next day diarrhoea after 6-OHDA occurred, persisted despite return normal myoelectric activity. Slow waves frequency gradually returns to control value after the fourth week.


CONCLUSIONS
Peripheral noradrenergic system has a significant effect on the frequency and variability of slow wave and minor role on its amplitude but no on diarrhoea pattern.
Koprowska
B
B
Katedra Patofizjologii Collegium Medicum UJ ul. Czysta 18, 31-121 Kraków.
Królczyk
G
G
Zurowski
D
D
Thor
P J
PJ
D000818:Animals; D003967:Diarrhea / Q000503:physiopathology; D007421:Intestine, Small / Q000503:physiopathology*; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D017208:Rats, Wistar; D013563:Sympathectomy, Chemical; D013565:Sympatholytics
D013565:Sympatholytics; D016627:Oxidopamine