title: Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties.
abstract: In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.
authors.affiliation: Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Sardinia, Italy. pinlab@uniss.it
authors.forename: G A
authors.initials: GA
authors.lastname: Pinna
authors.forename: G
authors.initials: G
authors.lastname: Loriga
authors.forename: G
authors.initials: G
authors.lastname: Murineddu
authors.forename: G
authors.initials: G
authors.lastname: Grella
authors.forename: M
authors.initials: M
authors.lastname: Mura
authors.forename: L
authors.initials: L
authors.lastname: Vargiu
authors.forename: C
authors.initials: C
authors.lastname: Murgioni
authors.forename: P
authors.initials: P
authors.lastname: La Colla
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D020008:Delavirdine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans
chemical_list: D019380:Anti-HIV Agents; D020008:Delavirdine