title: [Effect of zinc-intensified milk powder on hematopoiesis in mice].
abstract: OBJECTIVE
  To observe the effect of Zn-intensified milk powder and zinc on hematopoiesis in mice.
  
  
  METHODS
  Kunming mice were randomly divided into four groups (n = 9 each) (control group; milk powder group; equal zinc group; high zinc group) and fed on experimental diet for 24 weeks.
  
  
  RESULTS
  1. In high zinc group: the mice hemoglobin (Hb) declined (P < 0.05) after 12 wk of supplementation and were significantly lower (P < 0.01) than those in control group at 16 wk. At 24 wk, the mice showed lower Hb, red blood cell(RBC), hematocrit (HCT), and mean corpuscular volume (MCV) compared with control group (P < 0.05). Bone marrow aspirates revealed erythroid hyperplasia. Zinc concentrations in serum, liver and kidney were higher (P < 0.01) and copper was lower than that of control group(P < 0.01). 2. At 16 wk, no change occurred in milk powder group and equal zinc group. At 24 wk, parameters changed in milk powder group similar to those in high zinc group, and in equal zinc group liver and kidney copper was lower than that in control group (P < 0.05).
  
  
  CONCLUSIONS
  Ingestion of over-dosed zinc could induce anemia. Generally, intake of Zn-intensified milk powder is safe, but long-term intake of the milk powder may interfere with hematopoiesis.
authors.affiliation: Department of Laboratory Diagnosis, Hebei Medical University, Shijiazhuang 050017.
authors.forename: G
authors.initials: G
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D000818:Animals; D005519:Food Preservation; D005527:Food, Fortified; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008892:Milk; D011208:Powders; D011897:Random Allocation; D015032:Zinc / Q000494:pharmacology*
chemical_list: D011208:Powders; D015032:Zinc