title: Gene expression profiling of aging using DNA microarrays.
abstract: We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.
authors.affiliation: Department of Medicine, University of Wisconsin-Madison and Veterans Administration Hospital, Geriatric Research, Education and Clinical Center, Madison, WI 53705, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Weindruch
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kayo
authors.forename: Cheol Koo
authors.initials: CK
authors.lastname: Lee
authors.forename: Tomas A
authors.initials: TA
authors.lastname: Prolla
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001921:Brain; D002149:Energy Intake; D015870:Gene Expression; D020869:Gene Expression Profiling; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D011506:Proteins / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D046911:Macromolecular Substances; D011506:Proteins