Prooxidant-antioxidant balance in animals with enhanced hemoglobin-oxygen affinity under acute normobaric hypoxia.
The content of main lipid peroxidation (LPO) products and antioxidant defense (AD) factors were investigated in rats without a treatment and with preliminary rise of hemoglobin-oxygen affinity (HOA) by cyanate under acute normobaric environmental hypoxia. Under acute hypoxia the cyanate-treated rats expressed the lower contents of conjugated dienes (CD), thiobarbituric acid-reactive substances (TBARS), Schiff bases (SB) and higher alpha-tocopherol (alpha-T) concentration, and catalase (CAT) activity than in control animals (mainly in tissues). The regression analysis of HOA, LPO and AD parameters in investigated material indicated the close positive correlations of oxygen pressure for hemoglobin half-saturation (p50) with CD, TBARS, and SB, and negative correlation of p50 with alpha-T and CAT. The results of experiments with intended HOA increase during the hypoxia and observed weakened activities of the free radical processes suggest that blood oxygen-binding properties can have an important role in the mechanisms of prooxidant-antioxidant balance.
Korneichyk
V
V
Central Scientific Research Laboratory, Grodno Medical University, Grodno, Belarus.
Zinchuk
V
V
Borisiuk
M
M
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D004906:Erythrocyte Count; D005609:Free Radicals / Q000097:blood; D006454:Hemoglobins / Q000032:analysis*; D000860:Hypoxia / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D051381:Rats; D024502:alpha-Tocopherol / Q000097:blood
D000975:Antioxidants; D005609:Free Radicals; D006454:Hemoglobins; D002374:Catalase; D024502:alpha-Tocopherol