title: Phylogenetic analysis of avian paramyxovirus 1 strains isolated in Finland.
abstract: Eight strains of avian paramyxovirus type 1 (PMV-1) isolated in Finland during the last 3 decades were studied with reverse transcriptase polymerase chain reaction (RT-PCR) and subsequent sequence analysis of the region of 208 nucleotides covering the fusion (F) protein cleavage site. Both genetic and antigenic heterogeneity of the strains was significant. Direct epidemiological links between strains isolated during successive outbreaks, and also between strains isolated from wild fauna and from poultry or captive birds, were seen in this study. These results also support the previously published view that wild waterfowl serve as a reservoir for the apathogenic or low-pathogenic strains, allowing them to evolve further into pathogenic strains.
authors.affiliation: National Veterinary and Food Research Institute, Department of Virology, Helsinki, Finland. anita.huovilainen@eela.fi
authors.forename: A
authors.initials: A
authors.lastname: Huovilainen
authors.forename: C
authors.initials: C
authors.lastname: Ek-Kommone
authors.forename: R
authors.initials: R
authors.lastname: Manvell
authors.forename: L
authors.initials: L
authors.lastname: Kinnunen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001717:Birds; D002645:Chickens; D010856:Columbidae; D004196:Disease Outbreaks / Q000662:veterinary; D005387:Finland / Q000453:epidemiology; D008969:Molecular Sequence Data; D009521:Newcastle Disease / Q000453:epidemiology / Q000821:virology*; D009522:Newcastle disease virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification* / Q000472:pathogenicity; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014760:Viral Fusion Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D014760:Viral Fusion Proteins