title: Effect of disturbed plasma oxidant homeostasis on hemopoietic differentiation of polypotent bone marrow stem cells in mice treated with dipyridamole.
abstract: The choice of hemopoietic differentiation by polypotent bone marrow stem cells was studied by morphological and chemiluminescent methods. This choice occurred on day 7 after heterotopic bone marrow transplantation and dipyridamole administration, under the effect of oxidative homeostasis imbalance in the plasma. Dipyridamole increased total antioxidant activity and 10-fold reduced the intensity of free radical oxidation. Disaggregation therapy with dipyridamole reduced platelet count in the peripheral blood and decreased total plasma antioxidant activity.
authors.affiliation: Laboratory of Hematology, Institute of Cardiovascular Diseases, I. P. Pavlov State Medical University, St. Petersburg.
authors.forename: I N
authors.initials: IN
authors.lastname: Ivasenko
authors.forename: E V
authors.initials: EV
authors.lastname: Shlyakhto
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D016026:Bone Marrow Transplantation; D002452:Cell Count; D002454:Cell Differentiation / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology*; D005609:Free Radicals / Q000097:blood; D006410:Hematopoiesis / Q000187:drug effects; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology*; D006706:Homeostasis; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010084:Oxidation-Reduction; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013997:Time Factors; D014183:Transplantation, Heterologous
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole