An integrated genetic and physical map of the 650-kb region containing the congenital polycystic kidney (cpk) locus on mouse chromosome 12.
Mice homozygous for the congenital polycystic kidney (cpk) mutation develop a rapidly progressive form of polycystic kidney disease. We report an integrated genetic and physical map of the 650-kb region containing the cpk locus and the exclusion of Rrm2 and Idb2 as candidate cpk genes. Our study establishes the requisite foundation for positional cloning of the cpk gene.
Mrug
M
M
Division of Nephrology, University of Alabama at Birmingham, Birmingham AL 35294-0007, USA.
Green
W J
WJ
DasGupta
S
S
Beier
D R
DR
Lu
W
W
D'Eustachio
P
P
Guay-Woodford
L M
LM
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics*; D022202:Chromosomes, Artificial, Bacterial; D018244:Chromosomes, Artificial, Yeast; D020451:Contig Mapping; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D051797:Inhibitor of Differentiation Protein 2; D008297:Male; D051379:Mice / Q000235:genetics*; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D007690:Polycystic Kidney Diseases / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D012097:Repressor Proteins; D012262:Ribonucleoside Diphosphate Reductase / Q000235:genetics; D016324:Sequence Tagged Sites; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C497452:Idb2 protein, mouse; D051797:Inhibitor of Differentiation Protein 2; D012097:Repressor Proteins; D014157:Transcription Factors; C093713:ribonucleotide reductase M2; D012262:Ribonucleoside Diphosphate Reductase