[Effect of olipifate on the wound healing proces and relapse after resection of Pliss lymphosarcoma].
The investigation was concerned with the influence of preliminary injections of Olipiphat, irrigation of operative wound and combination of both procedures on healing and relapse processes, following resection of Pliss lymphosarcoma at different stages after transplantation into rats. The physical condition of the animals after tumor resection on days 12, 10 or 7 of tumor growth was better than in controls, as a result of irrigation of the operative wound with Olipiphat or in combination with preliminary injections of the drug: they came out from anesthesia quicker, tidied themselves up and moved about the cage. Irrigation of the wound with Olipiphat or in combination with preliminary injections followed by longer survival after surgery performed at all stages of tumor growth. Moreover, one animal out of 16 in each of the 4 Olipiphat-treated groups survived 60 days recurrence-free. The drug proved more effective in stimulating the healing of larger wounds but contributed to healing by first intention in all cases.
Reztsova
V V
VV
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Filov
V A
VA
Kuznetsova
N N
NN
Kil'maeva
N E
NE
Pliss
G B
GB
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016022:Case-Control Studies; D002455:Cell Division / Q000187:drug effects; D018572:Disease-Free Survival; D008031:Lignin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000601:surgery; D009368:Neoplasm Transplantation; D051381:Rats; D012008:Recurrence; D014945:Wound Healing / Q000187:drug effects*
D000970:Antineoplastic Agents; C413426:olipifat; D008031:Lignin