[Analysis of Myc gene family in laryngeal cancer].
OBJECTIVE
To study the abnormal amplification and role of Myc gene family in the development of laryngeal cancer.


METHODS
A PCR-PAGE-Laser scanning technique was applied.


RESULTS
There was no Myc gene amplification in the normal laryngeal tissues. The abnormal L-myc and C-myc gene were positive in 47% (15/32) of laryngeal cancers and 41% (13/32) of the cancers shown the N-myc gene amplification. Myc gene amplification was not related to age, sex and differentiation (P > 0.05), but the N-myc amplification was higher in patients with lymph node metastasis (P < 0.05).


CONCLUSIONS
The N-myc amplification may play a role of positive regulation in the lymph metastasis of laryngeal cancer. The abnormal amplification of Myc gene family is one of the causes in development of laryngeal cancer.
Quan
C
C
Department of Otolaryngology Head and Neck Surgery, First Teaching Hospital, Norman Bethune University of Medical Sciences, Changchun 130021.
Guo
X
X
D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic; D005260:Female; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged