title: Malignant transformation in synovial chondromatosis of the knee?
abstract: Although it has been reported, malignant transformation of synovial chondromatosis is rare. We report a case of malignant transformation of synovial chondromatosis in a knee to a low-grade chondrosarcoma, which was treated with synovial excision and total knee replacement. We also present a literature review of the subject. The case illustrates that malignant transformation should be suspected in chronic cases with a sudden exacerbation of symptoms and that interpretation of histology in cartilage lesions is difficult. It also demonstrates that even when guided biopsy techniques are used, the sampling error of a needle biopsy in any large lesion is unavoidable.
authors.affiliation: Middlesex Hospital, Mortimer Street, London W1N 8AA, UK. pete.orthopod@virgin.net
authors.forename: P
authors.initials: P
authors.lastname: Hallam
authors.forename: N
authors.initials: N
authors.lastname: Ashwood
authors.forename: J
authors.initials: J
authors.lastname: Cobb
authors.forename: A
authors.initials: A
authors.lastname: Fazal
authors.forename: W
authors.initials: W
authors.lastname: Heatley
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology*; D015838:Chondromatosis, Synovial / Q000473:pathology*; D002813:Chondrosarcoma / Q000473:pathology*; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008297:Male; D008875:Middle Aged