title: [Xerostomia after radiotherapy. More effective treatment by a mucin-containing spray?].
abstract: BACKGROUND
  After radiotherapy (XRT) for head and neck tumors, xerostomia is observed as a chronic side effect. We investigated whether the topical use of a mucin-containing spray can help patients to cope with this problem.
  
  
  METHODS
  A total of 73 patients with xerostomia post XRT received a bottle of the mucin spray (Saliva medac) and a questionnaire, 59 of which were completed and returned.
  
  
  RESULTS
  All patients had received some form of prior treatment, which had been applied 16 times/day on average (median: 15 times/day). The mucin spray had to be used less frequently, i.e., 11 times/day (median: 5 times/day), (p < 0.001, Wilcoxon's rank test). Additionally, they reported being able to sleep significantly better when using the mucin spray (2.9 vs 3.9 in the German school grading system: 1 = very good, 6 = poor; p < 0.001, Wilcoxon's rank test). The spray was well accepted by the patients.
  
  
  CONCLUSIONS
  The spray was useful against xerostomia in irradiated patients.
authors.affiliation: Abteilung für Strahlenheilkunde, Radiologische Universitätsklinik, Hugstetter Strasse 55, 79106 Freiburg i. Br. momm@mst1.ukl.uni-freiburg.de
authors.forename: F
authors.initials: F
authors.lastname: Momm
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: A
authors.initials: A
authors.lastname: Tsekos
authors.forename: R
authors.initials: R
authors.lastname: Guttenberger
mesh_terms: D000284:Administration, Oral; D006801:Humans; D009077:Mucins / Q000008:administration & dosage*; D010039:Otorhinolaryngologic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000628:therapy*; D012464:Saliva, Artificial / Q000008:administration & dosage*; D016896:Treatment Outcome; D014987:Xerostomia / Q000628:therapy*
chemical_list: D009077:Mucins; D012464:Saliva, Artificial