Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N- dimethylformamide exposure in Japanese workers.
OBJECTIVE
This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers.


METHODS
The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week were determined in 44 male and female Japanese workers.


CONCLUSIONS
The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.
Nomiyama
T
T
Industrial Toxicology and Occupational Medicine Unit, Catholic University of Louvain, Brussels, Belgium. nomiyama@sc.itc.keio.jp
Haufroid
V
V
Buchet
J P
JP
Miyauchi
H
H
Tanaka
S
S
Yamauchi
T
T
Imamiya
S
S
Seki
Y
Y
Omae
K
K
Lison
D
D
D000328:Adult; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D004126:Dimethylformamide; D004784:Environmental Monitoring; D005260:Female; D005559:Formamides / Q000378:metabolism*; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010641:Phenotype; D011110:Polymorphism, Genetic
D005559:Formamides; D004126:Dimethylformamide; D019392:Cytochrome P-450 CYP2E1; C002950:methylformamide