Conductometric determination of phenothiazine derivatives.
In this study, a conductometric titration method is proposed for the determination of phenothiazine derivatives in pure and dosage forms. The measurements were carried out in aqueous solution using sodium arsenite as titrant. The breaks in conductometric titration curves have been advantageously utilised for the quantitative determination of these drugs in pharmaceutical preparations. The method was found highly accurate and precise, having a relative standard deviation of less than 1.0% for all solutions containing from 1 to 25 mg of phenothiazine derivative compounds.
Zavialova
O
O
Department of Chemistry, N. Copernicus University, Toruń, Poland.
Zielińska
J
J
D014150:Antipsychotic Agents / Q000032:analysis*; D004553:Electric Conductivity; D004563:Electrochemistry; D007202:Indicators and Reagents; D010640:Phenothiazines
D014150:Antipsychotic Agents; D007202:Indicators and Reagents; D010640:Phenothiazines