Maternal carriership of factor V Leiden associated with pathological uterine artery doppler measurements during pregnancy.
To determine whether increased vascular resistance in the uterine artery is associated with carriership of factor V Leiden, a retrospective study was undertaken of 231 pregnant women who were monitored with Doppler velocimetry of the uterine arteries. These women had been part of a prospective study of 2,480 pregnant women in whom factor V Leiden had been analysed. When compared with non-carriers of factor V Leiden, carriers had a tendency towards an increased proportion of pathological Doppler measurements, including a significant increase in bilateral uterine artery notches (7/33 vs 16/198, relative risk 3.1; 95% CI 1.2-8.1). This suggests an increased vascular resistance in the uteroplacental circulation among carriers of factor V Leiden.
Lindqvist
P G
PG
Department of Obstetrics and Gynaecology, University of Lund, Sweden.
Gudmundsson
S
S
D001158:Arteries; D001783:Blood Flow Velocity / Q000502:physiology; D005165:Factor V; D005260:Female; D006801:Humans; D021041:Placental Circulation / Q000502:physiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D012189:Retrospective Studies; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance
C095381:factor V Leiden; D005165:Factor V