2'-Deoxycoformycin for hepatosplenic gammadelta T-cell lymphoma.
We describe a patient with unusually indolent hepatosplenic gammadelta T cell lymphoma characterised by severe lassitude and high fever. No significant responses were obtained to a range of chemotherapeutic and biological agents. 2'-deoxycoformycin (dCF), however, produced a dramatic and sustained clinical and histological response. This is the second recent report of gammadelta T cell lymphoma responding to dCF, suggesting this agent may have a specific role in this condition.
Grigg
A P
AP
Department of Clinical Haematology and Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia. andrew.grigg@mh.org.au
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000276:immunology; D016399:Lymphoma, T-Cell / Q000188:drug therapy* / Q000276:immunology; D015649:Pentostatin / Q000008:administration & dosage*; D016692:Receptors, Antigen, T-Cell, gamma-delta; D012074:Remission Induction; D013160:Splenic Neoplasms / Q000188:drug therapy* / Q000276:immunology
D000903:Antibiotics, Antineoplastic; D016692:Receptors, Antigen, T-Cell, gamma-delta; D015649:Pentostatin