[Inhibition of tumor invasion by new retinoid, 5-4A, and its mechanism of the action].
OBJECTIVE
To investigate the effect of 5-4A on the invasion of B16BL6 and to explore its mechanisms of action.


METHODS
The invasion of B16BL6 was studied using the reconstituted basement membrane invasion assay.


RESULTS
The phenotype of B16BL6 cells was obviously suppressed by 5-4A at the concentration of 4 x 10(-5) mol/L, and the inhibitory rate was 33.9%.


CONCLUSIONS
5-4A can inhibit invasion of B16BL6 cells and its mechanisms of action might be associated with the suppression of movement of tumor cells, decrease in the expression of type IV collagenase, and reversion of the phenotype of B16BL6 cells.
Cao
X
X
Institute of Material Medical, Chinese Academy of Medical Sciences, Peking Union Medical University, Beijing 100050.
Han
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D017364:Collagenases / Q000378:metabolism; D008546:Melanoma, Experimental / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D012176:Retinoids / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012176:Retinoids; D017364:Collagenases