title: Parametrization of electrophilicity for the prediction of the toxicity of aromatic compounds.
abstract: The aim of this study was to determine which descriptor best parametrized the electrophilicity of aromatic compounds with regard to their acute toxicity. To achieve this, toxicity data for 203 substituted aromatic compounds containing a nitro- or cyano group were evaluated in the 40-h Tetrahymena pyriformis population growth impairment assay. Quantitative structure-activity relationships (QSARs) were developed relating toxic potency [log(IGC(50)(-1))] with hydrophobicity quantified by the 1-octanol/water partition coefficient (log P) and electrophilic reactivity quantified by the molecular orbital parameters, either the energy of the lowest unoccupied molecular orbital (E(LUMO)) or maximum acceptor superdelocalizability (A(max)) was developed. For the full data set, E(LUMO) and A(max) were collinear (r = 0.87). A comparison of the QSARs [log(IGC(50)(-1)) = 0.40 log P - 0.94E(LUMO) - 1.27; n = 203, r(2) = 0.60, s = 0.49, F = 151] and [log(IGC(50)(-1)) = 0.37 log P + 13.1A(max) - 4.30; n = 203, r(2) = 0.70, s = 0.42, F = 237] reveals A(max) to be the better electrophilic parameter for modeling these data. Analysis of outliers indicates a preponderance of 4-subsituted nitrophenols and nitroanilines. Smaller datasets (51 and 102 compounds) selected in order to reduce the collinearity between A(max) and E(LUMO) were also evaluated. Results indicate A(max) to be the superior descriptor of electrophilicity for the purpose of toxicological QSARs for aromatic compounds. Development of QSARs using partial least-squares yielded similar results.
authors.affiliation: School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, England. m.t.cronin@livjm.ac.uk
authors.forename: M T
authors.initials: MT
authors.lastname: Cronin
authors.forename: N
authors.initials: N
authors.lastname: Manga
authors.forename: J R
authors.initials: JR
authors.lastname: Seward
authors.forename: G D
authors.initials: GD
authors.lastname: Sinks
authors.forename: T W
authors.initials: TW
authors.lastname: Schultz
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D004563:Electrochemistry; D005544:Forecasting; D006841:Hydrocarbons, Aromatic / Q000737:chemistry* / Q000633:toxicity*; D009596:Nitrophenols / Q000009:adverse effects / Q000737:chemistry; D009930:Organic Chemicals / Q000633:toxicity*; D011157:Population Dynamics; D012016:Reference Values; D013329:Structure-Activity Relationship; D013768:Tetrahymena / Q000187:drug effects; D018675:Toxicity Tests
chemical_list: D000814:Aniline Compounds; D006841:Hydrocarbons, Aromatic; D009596:Nitrophenols; D009930:Organic Chemicals