Qualitative and quantitative analysis of new amino acid derivatives of anticonvulsant activity.
Qualitative and quantitative methods for analysis of three new amino-acidic anticonvulsants of low neurotoxicity: pyrazole-3,5-dicarboxylic acid benzylamine (1), pyrazine-2-carboxylic acid benzylamine (2) and (R, S) N-acetyl-2-pyrrolidone-5-carboxylic acid benzylamide (3) have been developed. Qualitative analysis included characteristic reactions, chromatographic (TLC) investigations, IR and UV spectra interpretation and quantitative analysis involved spectrophotometric, chromatographic (HPLC) and acidimetric methods.
Pirianowicz-Chaber
E
E
Department of Drug Chemistry, The Medical University of Warsaw, Poland.
Paruszewski
R
R
D000596:Amino Acids / Q000032:analysis*; D000927:Anticonvulsants / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D000927:Anticonvulsants