Immunopathogenesis of HIV infection: concepts and questions.
HIV infection is characterized by deficits in both the number and function of CD4 T cells, deficits in the function of other cell lines, a marked increase in cellular activation, physical disruption of the immune environment and abnormal expression of cytokines. The mechanisms for these abnormalities are not fully understood; however, these abnormalities have clinical implications, and some are already the target of therapeutic intervention. HAART has altered the natural history of HIV while simultaneously raising new questions about pathogenesis.
Simmons
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D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D014775:Virus Activation