Lithium affects the reactivities of GalNAcalpha1-3GalNAc-lipid and fibrinopeptide A in mice.
The relationship between lithium and the reactivities of GalNAcalpha1-3GalNAc-lipid and fibrinopeptide A were investigated in mice. Lithium strongly decreased glycolipid reactivity and slightly increased peptide reactivity in a dose- and time-dependent manner. These substances showed antidepressive behavioral effects in mice via different neurological activities. This many suggest a mechanism of two different clinical effects of lithium: one of which is a strong antimanic effect and one of which is a weak antidepressive effect.
Masuda
Y
Y
Department of Neuropsychiatry, Akita University School of Medicine, Hondo, Japan.
Sugawara
J
J
Kawarada
Y
Y
Sugiyama
T
T
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D018692:Antimanic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005344:Fibrinopeptide A / Q000378:metabolism*; D006017:Glycolipids / Q000097:blood*; D016651:Lithium Carbonate / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013997:Time Factors
D000928:Antidepressive Agents; D018692:Antimanic Agents; D006017:Glycolipids; D005344:Fibrinopeptide A; D016651:Lithium Carbonate