title: Proteoglycans and orthodontic tooth movement.
abstract: Proteoglycans represent an important and diverse family of extracellular matrix components within the connective tissues of the periodontium. This review focuses on the function and metabolism of the various proteoglycans in periodontal tissues, such as alveolar bone and periodontal ligament, and considers their potential fate in response to an orthodontic force. Such considerations provide an important background in evaluating the potential for proteoglycan metabolites, alongside other connective tissue metabolites, as biomarkers for assessing the deep-seated metabolic changes and as a diagnostic tool in monitoring orthodontic tooth movement.
authors.affiliation: Department of Basic Dental Science, Dental School, University of Wales College of Medicine, Health Park, Cardiff, UK. waddingtonrj@cardiff.ac.uk
authors.forename: R J
authors.initials: RJ
authors.lastname: Waddington
authors.forename: G
authors.initials: G
authors.lastname: Embery
mesh_terms: D000818:Animals; D015415:Biomarkers; D016723:Bone Remodeling; D003799:Dental Stress Analysis; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D005883:Gingival Crevicular Fluid / Q000737:chemistry / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D017063:Outcome Assessment, Health Care / Q000379:methods; D010513:Periodontal Ligament / Q000378:metabolism; D010519:Periodontium / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism*; D014087:Tooth Movement Techniques
chemical_list: D015415:Biomarkers; D006025:Glycosaminoglycans; D011509:Proteoglycans; D020782:Matrix Metalloproteinases