Endoplasmic reticulum in the heart, a forgotten organelle?
Our hypothesis is that sarcoplasmic and endoplasmic reticulum Ca2+ stores may be functionally distinct compartments in cardiomyocytes. Sarcoplasmic reticulum Ca2+ store is responsible for control of excitation-contraction coupling whereas endoplasmic reticulum compartment may provide Ca2+ for housekeeping and transcriptional functions.
Mesaeli
N
N
Canadian Institutes of Health Research Group in Molecular Biology of Membrane Proteins and the Department of Biochemistry, University of Alberta, Edmonton.
Nakamura
K
K
Opas
M
M
Michalak
M
M
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism; D037282:Calreticulin; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006321:Heart / Q000254:growth & development; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D037102:Lectins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D012261:Ribonucleoproteins / Q000235:genetics / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D014158:Transcription, Genetic
D002135:Calcium-Binding Proteins; D037282:Calreticulin; D037102:Lectins; D012261:Ribonucleoproteins; D002118:Calcium