title: Nodulisporic acid A synthetic studies. 1. Overall strategy and construction of a western hemisphere subtarget.
abstract: In this, the first of two Letters, we outline our overall strategy for the construction of (+)-nodulisporic acid A (1), a representative member of a new class of indole diterpenes. In addition, we describe the efficient assembly of (-)-6, an advanced western hemisphere subtarget, comprising the ABC rings of (+)-nodulisporic acid A (1). The synthesis proceeded in 9% overall yield (longest linear sequence, 11 steps), exploiting a Shibasaki-Mori tandem transmetalation-cyclization to construct ring B. [reaction: see text]
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. smithab@sas.upenn.edu.
authors.forename: A B
authors.initials: AB
authors.lastname: Smith
authors.forename: H
authors.initials: H
authors.lastname: Ishiyama
authors.forename: Y S
authors.initials: YS
authors.lastname: Cho
authors.forename: K
authors.initials: K
authors.lastname: Ohmoto
mesh_terms: D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D007211:Indoles; C110703:nodulisporic acid A