Role of viral isolate in the etiopathogenetic determinism of HCV infection: diagnostic and epidemiological evaluation.
HCV genotyping by nucleic acid sequencing emphasizes the difficulties involved in carrying out a more precise determination of the infectant viral population, probably due in part to the finding of still unknown isolates. Signs of heterogeneity in the genotype composition of the viral quasi-species and its evolutionary dynamism over time, together with the role played by some, more potentially aggressive, isolates in causing hepatic damage, encourage a more in-depth study of such topics.
Ravera
G
G
ASL 3 Genovese Clinical Pathology Department, Genoa University.
Franceschini
M
M
Zanardi
S
S
Bottaro
L C
LC
Colombi
T
T
Percario
G F
GF
Carbone
M
M
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004279:DNA, Viral / Q000032:analysis; D018740:Genetic Heterogeneity; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D019562:Viral Load
D004279:DNA, Viral; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase