Receptor-Ck regulates giardia encystation process.
The study addressed to resolve the mechanism involved in cholesterol-dependent regulation of giardia encystation process, revealed that (a) the trophozoites have the ability to express genes coding for receptor-Ck and sterol element binding protein (SREBP); (b) inhibition of cholesterol dependent activation of receptor-Ck results in the upregulation of CWP-1 gene expression leading to encystation process. Based upon these findings, we propose that receptor-Ck dependent signalling is responsible for the regulation of giardia encystation process by cholesterol.
Kaul
D
D
Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Science and Research, Chandigarh, India.
Rani
R
R
Sehgal
R
R
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005872:Giardia / Q000254:growth & development* / Q000378:metabolism*; D015800:Protozoan Proteins / Q000378:metabolism; D018110:Receptors, Lipoprotein / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors
D022762:CCAAT-Enhancer-Binding Proteins; C094333:CWP1 protein, Giardia lamblia; D004268:DNA-Binding Proteins; D015800:Protozoan Proteins; D018110:Receptors, Lipoprotein; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; C113493:receptor-Ck; D002784:Cholesterol