title: Addiction and withdrawal--current views.
abstract: The final common pathway of addiction (the dopamine hypothesis of reward) has recently been evolving, with the mesocorticolimbic dopaminergic system now seen as key to natural rewards and drug-seeking behaviour, though perhaps having less of a role in the maintenance of such behaviour. The perception of a common pathway has meant that treatments for one drug of addiction have 'crossed-over' and become possible treatments for other addictive drugs.
authors.affiliation: Psychopharmacology Unit, School of Medical Sciences, University of Bristol, UK.
authors.forename: J K
authors.initials: JK
authors.lastname: Melichar
authors.forename: M R
authors.initials: MR
authors.lastname: Daglish
authors.forename: D J
authors.initials: DJ
authors.lastname: Nutt
mesh_terms: D000437:Alcoholism / Q000503:physiopathology; D019969:Amphetamine-Related Disorders / Q000503:physiopathology; D000818:Animals; D001569:Benzodiazepines; D002188:Cannabis; D019970:Cocaine-Related Disorders / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D009294:Narcotics / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000503:physiopathology*; D014029:Tobacco Use Disorder / Q000503:physiopathology
chemical_list: D009294:Narcotics; D001569:Benzodiazepines; D004298:Dopamine