Effects of inspired oxygen concentration on peripheral microcirculation studied by the rabbit ear chamber method.
The effects of oxygen inhalation on peripheral hemodynamics were studied in vivo. We observed changes in the cutaneous microcirculation in the rabbit under various inspiratory oxygen concentrations. Blood vessel diameter, blood-flow velocity and blood-flow rate were gradually reduced as oxygen concentrations were increased from 30%. These results indicate that inspiration of more than 30% oxygen causes deterioration of the microcirculation.
Komori
M
M
Department of Anesthesiology, School of Medicine, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 Japan.
Takada
K
K
Ozaki
M
M
D000280:Administration, Inhalation; D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000648:ultrastructure; D001783:Blood Flow Velocity / Q000187:drug effects; D015194:Diffusion Chambers, Culture; D004423:Ear / Q000098:blood supply*; D008833:Microcirculation / Q000187:drug effects*; D008853:Microscopy; D010100:Oxygen / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D019736:Prostheses and Implants; D011817:Rabbits; D017382:Reactive Oxygen Species; D013481:Superoxides / Q000378:metabolism; D014661:Vasoconstriction / Q000187:drug effects*; D014699:Venules / Q000187:drug effects / Q000648:ultrastructure
D017382:Reactive Oxygen Species; D013481:Superoxides; D010100:Oxygen