Genetically engineered mice and their use in aging research.
Genetically engineered animal models have been and will continue to be invaluable for exploring the basic mechanisms involved in the aging process as well as in extending our understanding of diseases found to be more prevalent in the older human population. Continued development of such in vivo systems will allow scientists to further dissect the role genetic and environmental factors play in aging and in age-related disease states and to enhance our understanding of these processes. In this article we discuss techniques involved in the development of such models and review some examples of laboratory mouse strains that have been used to study either normal aging or select diseases associated with aging.
Andersen
J K
JK
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA. jandersen@buckinstitute.org
D000375:Aging / Q000235:genetics / Q000276:immunology / Q000523:psychology; D000544:Alzheimer Disease; D000818:Animals; D016922:Cellular Senescence; D018390:Gene Targeting / Q000379:methods; D005818:Genetic Engineering; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D010300:Parkinson Disease; D012106:Research; D019076:Transgenes