Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.
Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.
Padmanabhan
S
S
CeNeS Pharmaceuticals Inc., 333 Providence Highway, Norwood, MA 02062, USA. padman12@hotmail.com
Lavin
R C
RC
Thakker
P M
PM
Guo
J
J
Zhang
L
L
Moore
D
D
Perlman
M E
ME
Kirk
C
C
Daly
D
D
Burke-Howie
K J
KJ
Wolcott
T
T
Chari
S
S
Berlove
D
D
Fischer
J B
JB
Holt
W F
WF
Durant
G J
GJ
McBurney
R N
RN
D000818:Animals; D004353:Drug Evaluation, Preclinical; D019791:Guanidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D008811:Mice, Inbred DBA; D026941:Sodium Channel Blockers
D026941:Sodium Channel Blockers; D019791:Guanidine