Influence of human T-cell lymphocytotropic virus type 1 infection on serologic and skin tests for strongyloidiasis.
The aim of this study was to determine whether human T-cell lymphocytotropic virus type 1 (HTLV-1) infection may affect the levels of parasite-specific immunoglobulin (Ig) G and IgE and the positivity of the skin test for strongyloidiasis. Participants included 67 patients with strongyloidiasis (40 without HTLV-1 infection and 27 coinfected with HTLV-1). We determined IgG and IgE levels by enzyme-linked immunosorbent assay, and the immediate hypersensitivity skin test was performed with the metabolic Strongyloides stercoralis antigen. Specific IgE levels and the size of skin reactions in patients without HTLV-1 were higher (P < 0.01) than those observed in patients coinfected with HTLV-1. Additionally, 89% of patients without HTLV-1 had specific IgE and 92.5% had positive skin tests; however, these values were significantly reduced (P < 0.01) in patients coinfected with HTLV-1 (44% and 59%, respectively). These data show that HTLV-1 infection decreases the sensitivity of detection of S. stercoralis-specific IgE, the size of the immediate hypersensitivity reaction, and the sensitivity of these tests in the diagnosis of strongyloidiasis.
Porto
A F
AF
Serviço de Imunologia do Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Brazil.
Oliveira Filho
J
J
Neva
F A
FA
Orge
G
G
Alcântara
L
L
Gam
A
A
Carvalho
E M
EM
D000328:Adult; D000909:Antibodies, Helminth / Q000097:blood; D005260:Female; D015490:HTLV-I Infections / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D012882:Skin Tests; D013322:Strongyloidiasis / Q000175:diagnosis*
D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D007073:Immunoglobulin E