Search for new chemical entities as menses inducing agents.
In continuation of an ongoing program on developing nonsteroidal pregnancy interceptives to be used as a menses regulating agent, a new class of compounds belonging to 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones series has been investigated for pregnancy interceptive activity in the hamster and rat. The compounds were administered (subcutaneous) on days 4-8 (hamster) and 5-9 (rat) post coitum (PC). The animals were laparotomized on days 12 (hamster) and 16 (rat) PC. To derive percent efficacy, the total number of implantation was divided by the number of normal and resorbed implantations. Among the 14 compounds evaluated, three were found to intercept pregnancy by 100%. Another compound was active by 75%, whereas the rest were inactive. None of the active compounds were, however, active in rat with this schedule. Results indicate that the observed species- and schedule-specific activity owes its origins to differences in the implantation physiology and early post-implantation development between the two species. The study, nevertheless, offers an insight to the new class of compounds for this activity.
Mehrotra
P K
PK
Endocrinology Division, Central Drug Research Institute, Lucknow 226 001, India. Purshottam123@rediffmail.com
Kitchlu
S
S
Batra
S
S
Srivastava
S
S
Bhaduri
A P
AP
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D003512:Cyclohexanones / Q000008:administration & dosage* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008598:Menstruation / Q000187:drug effects*; D008647:Mesocricetus; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
D000020:Abortifacient Agents, Nonsteroidal; D003512:Cyclohexanones