Current topics on immunoadsorption therapy.
Immunoadsorption therapy has become popular for the treatment of various autoimmune diseases as the number of clinically available immunoadsorption columns increases. Immunoadsorption columns for plasma perfusion or direct hemoperfusion available for clinical use such as the Immusorba TR and PH, Selesorb, Prosorba, Immunosorba, Ig-Therasorb, and Medisorba MG are reviewed in the first part of this article. The peptide columns which immobilize peptides as the ligands are described in the second half. The peptide column has the potential to deliver specific adsorbents if a peptide is appropriately designed to remove the pathogenic substances specifically responsible for the given disease.
Nakaji
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Medical Products Development Department, Kuraray Co., Ltd., Kurashiki, Japan. Shuhei_Nakaji@kuraray.co.jp
D001327:Autoimmune Diseases / Q000628:therapy*; D006464:Hemoperfusion; D006801:Humans; D007163:Immunosorbent Techniques; D009157:Myasthenia Gravis / Q000503:physiopathology / Q000628:therapy; D010392:Pemphigus / Q000628:therapy; D010956:Plasmapheresis