title: Decade-long experience with surgical therapy of myasthenia gravis: early complications of 324 transsternal thymectomies.
abstract: BACKGROUND
  We studied the incidences and evaluated the management of early postoperative complications after thymectomy for myasthenia gravis.
  
  
  METHODS
  During the period between 1987 and 1996, 324 thymectomies were performed through median sternotomy access under general anesthesia. Postoperative management was administered according to a standardized protocol of anticholinesterase medication, which was withdrawn for the 48 hours of obligatory postoperative mechanical ventilation. The mean age of patients was 34 years (range, 8 to 71 years).
  
  
  RESULTS
  One hundred forty-nine patients made an uneventful recovery; 104 patients had only minor complications, whereas 71 patients had major complications. The mortality rate was 0.6% (2 patients). The major surgical complications were recorded as sternal bleeding (1 patient) and sternal disruption (1 patient). The major general complications were recorded as tracheal stenosis (1 patient), pneumonia (3 patients), heart failure (1 patient), gastric hemorrhage (1 patient), and respiratory insufficiency (71 patients). Forty-six reintubations were performed on 40 patients and 19 tracheostomies (6%) were performed postoperatively.
  
  
  CONCLUSIONS
  The excessive incidence of respiratory insufficiency and airway-associated morbidity was potentially related, at least partially, to prolonged mechanical ventilation and withdrawal of anticholinesterase medication. Earlier weaning of patients with revision of 48-hour withdrawal of anticholinesterase medication is necessary.
authors.affiliation: Department of Surgery and Anesthesiology, Buda MAV Hospital, Budapest, Hungary. kasaczel@matavnet.hu
authors.forename: J
authors.initials: J
authors.lastname: Kas
authors.forename: D
authors.initials: D
authors.lastname: Kiss
authors.forename: V
authors.initials: V
authors.lastname: Simon
authors.forename: E
authors.initials: E
authors.lastname: Svastics
authors.forename: L
authors.initials: L
authors.lastname: Major
authors.forename: A
authors.initials: A
authors.lastname: Szobor
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D013249:Sternum; D013934:Thymectomy / Q000009:adverse effects* / Q000379:methods*; D013997:Time Factors