Failed challenge with quetiapine after neuroleptic malignant syndrome with conventional antipsychotics.
Neuroleptic malignant syndrome (NMS) is an uncommon but potentially life-threatening adverse effect associated with conventional antipsychotic agents. The syndrome is characterized by muscular rigidity, hyperpyrexia, altered consciousness, and autonomic dysfunction. Few cases of quetiapine-induced NMS have been reported. A 54-year-old man was unsuccessfully challenged with quetiapine after conventional antipsychotic-induced NMS.
Hatch
C D
CD
Clinical and Administrative Division, College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA.
Lund
B C
BC
Perry
P J
PJ
D000544:Alzheimer Disease / Q000150:complications; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002746:Chlorpromazine / Q000009:adverse effects; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000009:adverse effects*; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications; D008140:Lorazepam / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011595:Psychomotor Agitation / Q000150:complications / Q000188:drug therapy; D000069348:Quetiapine Fumarate
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D006220:Haloperidol; D008140:Lorazepam; D002746:Chlorpromazine