Warthin-like tumor variant of papillary thyroid carcinoma: case report and literature review.
A tumor approximately 4.0 x 3.0 cm in size with a cystic change was observed in the left lobe of the thyroid gland of a 52-year-old woman. The removed tumor had lymph follicle formation with a germinal center. This lymphatic tissue showed papillary and island-like growth; the growths were surrounded by atypical epithelium showing nuclear features of papillary carcinoma. The atypical epithelium had ground-glass nuclei with nuclear grooves, clearly indicating intranuclear cytoplasmic inclusion bodies. No chronic thyroiditis was observed in the background of the patient. Parts of the metastatic lymph nodes had cells with an eosinophilic cytoplasm, clearly showing an intratumor lymph follicle formation, as in the primary lesion. This is a rare case of thyroid papillary carcinoma similar to Warthin's tumor of the salivary gland. Here we present this case, with a review of previously published reports.
Urano
M
M
Department of Pathology, Fujita Health University, School of Medicine, Aichi, Japan. uranom@fujita-hu.ac.jp
Abe
M
M
Kuroda
M
M
Mizoguchi
Y
Y
Horibe
Y
Y
Kasahara
M
M
Tanaka
K
K
Sudo
K
K
Hirasawa
Y
Y
D000235:Adenolymphoma / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*
D013954:Thyroglobulin