Novel oxindole derivatives and their biological activity.
The antifungal activity of fourteen novel derivatives of oxindole with side chain was studied using representatives of toxinogenic, phytopathogenic and dermatophytic filamentous fungi. Derivatives with exocyclic C=C bond in position C-3 exhibited a higher antifungal activity compared with derivatives with an exocyclic C-C bond in the same position. The strongest antifungal effects were shown by 3-(-2-thienoylmethylidene)-indol-2(3H)-ones.
Strigácová
J
J
Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia. strigaco@chelin.chtf.stuba.sk
Hudecová
D
D
Mikulásová
M
M
Varecka
L
L
Lásiková
A
A
Végh
D
D
D000935:Antifungal Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects; D020171:Botrytis / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D009152:Mutagenicity Tests; D010084:Oxidation-Reduction; D010407:Penicillium / Q000378:metabolism; D012233:Rhizopus / Q000187:drug effects*; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D007211:Indoles