title: Prognostic value of carcinoembryonic antigen (CEA) in tumor tissue of patients with colorectal cancer.
abstract: To establish the prognostic value of carcinoembryonic antigen (CEA) concentration in tumor tissue (T-CEA), normal colonic mucosa (N-CEA) and pre-operative serum (S-CEA), we studied 79 patients who underwent resections for colorectal cancer. The patients were separated into groups reflecting laboratory values lower or higher than a diagnostic value (S-CEA) or the median value of the entire population (T-CEA, N-CEA). A high S-CEA predicted for more advanced stage (p = 0.028), whereas no association was noted between stage and CEA concentration for T-CEA and N-CEA groups. The high S-CEA and T-CEA groups had a worse clinical outcome (p=0.0036 and p=0.024, respectively), while survival of high versus low N-CEA groups did not differ. By Cox's regression analysis, high T-CEA concentration was an independent variable for poor outcome (Hazard ratio, 3.15), while S-CEA and N-CEA were not. In conclusion, a high T-CEA concentration was the only independent predictor of poor outcome after resection for colorectal cancer.
authors.affiliation: First Department of Surgery, Nagasaki University School of Medicine, Sakamoto, Japan. nakagoe@net.nagasaki-u.ac.j
authors.forename: T
authors.initials: T
authors.lastname: Nakagoe
authors.forename: T
authors.initials: T
authors.lastname: Sawai
authors.forename: H
authors.initials: H
authors.lastname: Ayabe
authors.forename: T
authors.initials: T
authors.lastname: Nakazaki
authors.forename: H
authors.initials: H
authors.lastname: Ishikaw
authors.forename: K
authors.initials: K
authors.lastname: Hatano
authors.forename: K
authors.initials: K
authors.lastname: Kajiwara
authors.forename: K
authors.initials: K
authors.lastname: Miyashita
authors.forename: T
authors.initials: T
authors.lastname: Matsuo
authors.forename: T
authors.initials: T
authors.lastname: Nogawa
authors.forename: K
authors.initials: K
authors.lastname: Arisawa
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D009363:Neoplasm Proteins