Effect of disturbed plasma oxidant homeostasis on hemopoietic differentiation of polypotent bone marrow stem cells in mice treated with dipyridamole.
The choice of hemopoietic differentiation by polypotent bone marrow stem cells was studied by morphological and chemiluminescent methods. This choice occurred on day 7 after heterotopic bone marrow transplantation and dipyridamole administration, under the effect of oxidative homeostasis imbalance in the plasma. Dipyridamole increased total antioxidant activity and 10-fold reduced the intensity of free radical oxidation. Disaggregation therapy with dipyridamole reduced platelet count in the peripheral blood and decreased total plasma antioxidant activity.
Ivasenko
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IN
Laboratory of Hematology, Institute of Cardiovascular Diseases, I. P. Pavlov State Medical University, St. Petersburg.
Shlyakhto
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EV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D016026:Bone Marrow Transplantation; D002452:Cell Count; D002454:Cell Differentiation / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology*; D005609:Free Radicals / Q000097:blood; D006410:Hematopoiesis / Q000187:drug effects; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology*; D006706:Homeostasis; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010084:Oxidation-Reduction; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013997:Time Factors; D014183:Transplantation, Heterologous
D000975:Antioxidants; D005609:Free Radicals; D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole