title: Flavonoids: structural requirements for antiproliferative activity on breast cancer cells.
abstract: Several classes of flavonoids (flavones, flavanones, 2'-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast cancer cells. Structure-activity relationships of these compounds were discussed. 2'-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas flavones and flavan-4-ols appeared to be weak inhibitory agents except 7,8-dihydroxyflavone.
authors.affiliation: UPRES EA 1085, 'Biomolécules et cibles cellulaires tumorales', Faculté de Pharmacie, 2 rue du Docteur Marcland, 87025 Cedex, Limoges, France.
authors.forename: C
authors.initials: C
authors.lastname: Pouget
authors.forename: F
authors.initials: F
authors.lastname: Lauthier
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: C
authors.initials: C
authors.lastname: Fagnere
authors.forename: J P
authors.initials: JP
authors.lastname: Basly
authors.forename: C
authors.initials: C
authors.lastname: Delage
authors.forename: A J
authors.initials: AJ
authors.lastname: Chulia
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids