title: Evolution: constantly avoiding mutation.
abstract: The genomic mutation rate of the archaeon Sulfolobus acidocaldarius, which inhabits a harsh and potentially mutagenic environment, surprisingly agrees well with the previously observed constancy of genomic mutation rates in microbes. The evolutionary explanation for this constancy of genomic mutation rates remains obscure.
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: P
authors.initials: P
authors.lastname: Sniegowski
mesh_terms: D019843:Archaeal Proteins; D001426:Bacterial Proteins / Q000235:genetics; D019143:Evolution, Molecular; D020745:Genome, Archaeal; D009154:Mutation; D009963:Orotic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D016945:Sulfolobus acidocaldarius / Q000187:drug effects / Q000235:genetics*
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins; C407406:pyrF protein, Archaeal; D009963:Orotic Acid; C001242:5-fluoroorotic acid