title: Sensory adaptation in naive peripheral CD4 T cells.
abstract: T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs. Here we show that pMHC contact modulates the expression of CD5 by naive CD4 T cells in a process that requires the continued expression of p56(lck). Reduced CD5 levels in T cells deprived of pMHC contact are predictive of elevated Ca(2)+ responses to subsequent TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact may be important for regulating naive CD4 T cell responsiveness.
authors.affiliation: Lymphocyte Development Group, MRC Clinical Sciences Centre, ICSM Hammersmith Hospital, London W12 0NN, UK.
authors.forename: K
authors.initials: K
authors.lastname: Smith
authors.forename: B
authors.initials: B
authors.lastname: Seddon
authors.forename: M A
authors.initials: MA
authors.lastname: Purbhoo
authors.forename: R
authors.initials: R
authors.lastname: Zamoyska
authors.forename: A G
authors.initials: AG
authors.lastname: Fisher
authors.forename: M
authors.initials: M
authors.lastname: Merkenschlager
mesh_terms: D000222:Adaptation, Physiological / Q000276:immunology*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens / Q000096:biosynthesis / Q000276:immunology; D006183:H-2 Antigens / Q000096:biosynthesis / Q000276:immunology; D006239:Haplotypes; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000096:biosynthesis / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D051379:Mice
chemical_list: D018956:CD5 Antigens; D006183:H-2 Antigens; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)