title: Failed challenge with quetiapine after neuroleptic malignant syndrome with conventional antipsychotics.
abstract: Neuroleptic malignant syndrome (NMS) is an uncommon but potentially life-threatening adverse effect associated with conventional antipsychotic agents. The syndrome is characterized by muscular rigidity, hyperpyrexia, altered consciousness, and autonomic dysfunction. Few cases of quetiapine-induced NMS have been reported. A 54-year-old man was unsuccessfully challenged with quetiapine after conventional antipsychotic-induced NMS.
authors.affiliation: Clinical and Administrative Division, College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Hatch
authors.forename: B C
authors.initials: BC
authors.lastname: Lund
authors.forename: P J
authors.initials: PJ
authors.lastname: Perry
mesh_terms: D000544:Alzheimer Disease / Q000150:complications; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002746:Chlorpromazine / Q000009:adverse effects; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000009:adverse effects*; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications; D008140:Lorazepam / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011595:Psychomotor Agitation / Q000150:complications / Q000188:drug therapy; D000069348:Quetiapine Fumarate
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D006220:Haloperidol; D008140:Lorazepam; D002746:Chlorpromazine