title: APOE and APOC1 genetic polymorphisms in age-associated memory impairment.
abstract: We studied the distribution of two genetic polymorphisms (APOE and APOC1) in a sample of 100 subjects fulfilling the NIMH criteria for age-associated memory impairment (AAMI) and 124 controls. We found significant associations both for APOE and APOC1 loci and their combinations with the AAMI condition. The findings in our sample suggest that memory-impaired subjects as described by the NIMH may be genetically differentiated from normally aging subjects in relation to these two polymorphisms and indicate the interest of considering variations in the APOC1 gene for further studies in cognitive aging.
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain. dbatres@psi.ub.es
authors.forename: D
authors.initials: D
authors.lastname: Bartrés-Faz
authors.forename: I C
authors.initials: IC
authors.lastname: Clemente
authors.forename: C
authors.initials: C
authors.lastname: Junqué
authors.forename: N
authors.initials: N
authors.lastname: Valveny
authors.forename: A
authors.initials: A
authors.lastname: López-Alomar
authors.forename: J
authors.initials: J
authors.lastname: Sánchez-Aldeguer
authors.forename: A
authors.initials: A
authors.lastname: López-Guillén
authors.forename: P
authors.initials: P
authors.lastname: Moral
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics*; D001056:Apolipoproteins C / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D003071:Cognition; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D001056:Apolipoproteins C; D001057:Apolipoproteins E