title: Deactivation of thalamocortical activity is responsible for suppression of parkinsonian tremor by thalamic stimulation: a 99mTc-ECD SPECT study.
abstract: Four patients with Parkinson's disease (PD) achieved excellent improvement of their unilateral tremor by chronic deep brain stimulation (DBS) of the contralateral ventral intermediate (Vim) nucleus of the thalamus. Repeated measurements of cerebral blood flow were obtained 14 days apart off and on stimulation using 99mTc-ECD SPECT. Subjects were scanned at rest and the data were compared with those of normal healthy volunteers. During stimulation, there were highly significant deactivations in the motor area and supplementary motor area on the electrode side and in the prefrontal area and the anterior cingulum bilaterally. No cerebellar deactivation was detected. We conclude that the mechanism responsible for suppression of parkinsonian tremor by thalamic stimulation is deactivation of thalamocortical activity.
authors.affiliation: Department of Nuclear Medicine, Inselspital, University of Berne, Berne, Switzerland.
authors.forename: J P
authors.initials: JP
authors.lastname: Wielepp
authors.forename: J M
authors.initials: JM
authors.lastname: Burgunder
authors.forename: T
authors.initials: T
authors.lastname: Pohle
authors.forename: E P
authors.initials: EP
authors.lastname: Ritter
authors.forename: J A
authors.initials: JA
authors.lastname: Kinser
authors.forename: J K
authors.initials: JK
authors.lastname: Krauss
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003545:Cysteine / Q000031:analogs & derivatives*; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology; D009434:Neural Pathways; D015609:Organotechnetium Compounds; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D017397:Prefrontal Cortex / Q000503:physiopathology; D019275:Radiopharmaceuticals; D013788:Thalamus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016896:Treatment Outcome; D014202:Tremor / Q000209:etiology*
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine