Putting the stress on senescence.
Cultivation of primary cells over many generations eventually results in a reproducible loss of proliferative potential that has been termed 'replicative senescence'. Recent work has revealed the heterogeneity of senescence. Importantly, the analysis of the various aspects and types of senescence has turned out to be very informative about numerous in vivo processes, and particularly about carcinogenesis.
Serrano
M
M
Department of Immunology and Oncology, National Center of Biotechnology (CSIC), Campus de Cantoblanco, Madrid E-28049, Spain. mserrano@cnb.uam.es
Blasco
M A
MA
D000818:Animals; D016922:Cellular Senescence; D004249:DNA Damage; D006801:Humans; D051379:Mice; D008954:Models, Biological; D018384:Oxidative Stress; D016283:Proto-Oncogene Proteins p21(ras) / Q000502:physiology; D016615:Telomere / Q000502:physiology; D014158:Transcription, Genetic
C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)