title: Multidrug resistant Mycobacterium leprae from patients with leprosy.
abstract: Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae.
authors.affiliation: Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Matsuoka
authors.forename: N
authors.initials: N
authors.lastname: Nakata
authors.forename: M
authors.initials: M
authors.lastname: Kai
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Kashiwabara
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000494:pharmacology / Q000627:therapeutic use; D001483:Base Sequence; D017931:DNA Primers; D004269:DNA, Bacterial / Q000187:drug effects / Q000235:genetics; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005798:Genes, Bacterial / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007917:Leprostatic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy* / Q000382:microbiology*; D051379:Mice; D008969:Molecular Sequence Data; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000235:genetics; D015242:Ofloxacin / Q000494:pharmacology / Q000627:therapeutic use; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000904:Antibiotics, Antitubercular; D017931:DNA Primers; D004269:DNA, Bacterial; D007917:Leprostatic Agents; D015242:Ofloxacin; D012293:Rifampin