title: Catalytic nucleophilic acyl substitution of anhydrides by amphoteric vanadyl triflate.
abstract: [reaction--see text] Among four vanadyl species examined, vanadyl triflate was the most efficient catalyst to facilitate nucleophilic acyl substitution of anhydrides with a myriad array of alcohols, amines, and thiols in high yields and high chemoselectivity. By using mixed-anhydride technique, one can achieve oleate and peptide syntheses. In marked contrast to common metal triflates, the amphoteric character of the V=O unit in vanadyl species was proven to be responsible for the catalytic profile in this process.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan, ROC. chefv043@scc.ntnu.edu.tw
authors.forename: C T
authors.initials: CT
authors.lastname: Chen
authors.forename: J H
authors.initials: JH
authors.lastname: Kuo
authors.forename: C H
authors.initials: CH
authors.lastname: Li
authors.forename: N B
authors.initials: NB
authors.lastname: Barhate
authors.forename: S W
authors.initials: SW
authors.lastname: Hon
authors.forename: T W
authors.initials: TW
authors.lastname: Li
authors.forename: S D
authors.initials: SD
authors.lastname: Chao
authors.forename: C C
authors.initials: CC
authors.lastname: Liu
authors.forename: Y C
authors.initials: YC
authors.lastname: Li
authors.forename: I H
authors.initials: IH
authors.lastname: Chang
authors.forename: J S
authors.initials: JS
authors.lastname: Lin
authors.forename: C J
authors.initials: CJ
authors.lastname: Liu
authors.forename: Y C
authors.initials: YC
authors.lastname: Chou