Lymphatic tumor emboli of perirenal fat in patient with nephrotic syndrome receiving renal biopsy, ultimately revealed gastric adenocarcinoma with membranous glomerulonephritis.
The association of malignancy with nephrotic syndrome and renal histopathologic abnormalities is well documented. Paraneoplastic proteinuria caused by membranous glomerulonephritis usually is made simultaneously with the diagnosis of a malignant tumor, or the two conditions are diagnosed within a year of each other. We reported a patient who presented with nephrotic syndrome initially. Incidentally, in kidney specimens, pathologic findings showed perirenal fatty tissue with malignancy tumor emboli in lymphatics. Thereafter, gastric adenocarcinoma was diagnosed by gastrointestinal panendoscopy with gastric biopsy under impression of malignancy associated with glomerulonephritis. Patient died of complications of malignancy-related disseminated intravascular coagulation without chemotherapy after confirming diagnosis was made three months later.
Fang
J T
JT
Department of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan. fangjits@ms4.hinet.net
Chen
Y C
YC
Hsueh
S
S
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000556:secondary*; D001707:Biopsy, Needle; D017809:Fatal Outcome; D005773:Gastroscopy; D015433:Glomerulonephritis, Membranous / Q000150:complications / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000150:complications / Q000473:pathology*; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology*