Expression of pyrimidine nucleoside phosphorylase (PyNPase) in colorectal cancer.
BACKGROUND
We investigated the expression of PyNPase both in cancer cells and in stroma cells to clarify the correlation between PyNPase expression and the prognosis of patients with colorectal cancer.


METHODS
Using immunohistochemical staining with an anti-PyNPase antibody, the PyNPase expression in tissues from 114 patients with stage II or III colorectal cancer was examined. From the correlation between PyNPase expression and the clinicopathological findings, the prognosis for survival was analyzed.


RESULTS
The expression of PyNPase was classified as negative or positive on the basis of staining. No relationship between PyNPase expression and any of the clinicopathological findings was identified. However, a relationship was observed regarding positive staining between cancer cells and stroma cells. The prognosis of patients with positive staining in both cancer cells and stroma was worse than that of other patients. In multivariate analyses, expression in cancer cells was the strongest predictor of prognosis.


CONCLUSIONS
PyNPase expression appears to be a relevant factor for predicting the prognosis of colorectal cancer.
Osanai
T
T
Digestive Surgery, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan. t-osanai.srg2@tmd.ac.jp
Ichikawa
W
W
Takagi
Y
Y
Uetake
H
H
Nihei
Z
Z
Sugihara
K
K
D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010430:Pentosyltransferases / Q000096:biosynthesis*; D011379:Prognosis; D057845:Pyrimidine Phosphorylases; D012004:Rectal Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D013194:Staining and Labeling; D015996:Survival Rate
D010430:Pentosyltransferases; D057845:Pyrimidine Phosphorylases