Mechanism of action of the des-F(6) quinolone BMS-284756 measured by supercoiling inhibition and cleavable complex assays.
BMS-284756 (T-3811ME), a novel des-F(6) quinolone, was tested in the supercoiling inhibition and cleavable complex assays against Escherichia coli DNA gyrase, a target of quinolones. The results suggest that BMS-284756 has the same mechanism of action against DNA gyrase as other quinolones and a similar level of potency.
Wu
P
P
Bristol-Myers Squibb Company Pharmaceutical Research Institute, Wallingford, Connecticut, USA.
Lawrence
L E
LE
Denbleyker
K L
KL
Barrett
J F
JF
D000890:Anti-Infective Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000187:drug effects*; D004278:DNA, Superhelical / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007211:Indoles; D008826:Microbial Sensitivity Tests; D015363:Quinolones; D059005:Topoisomerase II Inhibitors
D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D004278:DNA, Superhelical; D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D007211:Indoles; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; C419689:garenoxacin