Enantioselective pinacol coupling of aldehydes mediated and catalyzed by chiral titanium complexes.
Starting from easily available chiral Schiff bases, a straightforward synthesis of air-stable titanium(IV) complexes was devised. Asymmetric pinacol coupling of aromatic aldehydes mediated and catalyzed by the corresponding low valent complexes afforded the chiral diols with high yields and enantioselectivities up to 91%. [reaction: see text]
Bensari
A
A
Laboratoire de Chimie Organique et Médicinale, département de chimie, place Louis Pasteur 1, Université catholique de Louvain, 1348 Louvain la Neuve, Belgium.
Renaud
J L
JL
Riant
O
O