[Development of new antidiabetic drugs through the advanced knowledge of molecular biology in insulin signal transduction].
The advancement of molecular biology in the field of insulin signal transduction is remarkable and the knowledge acquired through the recent research can be applied to the development of new antidiabetic drugs. There are several serine-threonine kinases and tyrosine phosphatases which can decrease insulin action at the state of diabetes and adipocytokines, which are produced from enlarged adipocytes, may affect insulin signal transduction. To prevent these proteins and cytokines from suppressing insulin action, specific molecular targets could be identified and the new agents can be developed for the normal insulin signaling and the development of new antidiabetic drugs is ongoing at present time.
Kobayashi
M
M
First Department of Internal Medicine, Toyama Medical & Pharmaceutical University.
Hori
H
H
Kawahara
J
J
D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D003920:Diabetes Mellitus / Q000209:etiology; D015195:Drug Design; D051275:Glucose Transporter Type 4; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000502:physiology*; D009004:Monosaccharide Transport Proteins / Q000378:metabolism; D009124:Muscle Proteins; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013844:Thiazoles / Q000494:pharmacology; D045162:Thiazolidinediones
D016207:Cytokines; D051275:Glucose Transporter Type 4; D007004:Hypoglycemic Agents; D007328:Insulin; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495692:SLC2A4 protein, human; D013844:Thiazoles; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione; D017346:Protein Serine-Threonine Kinases; D010744:Phosphoric Monoester Hydrolases; D017027:Protein Tyrosine Phosphatases; C098706:INPPL1 protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases