title: The influence of low-, normal-, and high-carbohydrate meals on blood pressure in elderly patients with postprandial hypotension.
abstract: BACKGROUND
  Postprandial hypotension (PPH) is a common and serious disorder of blood pressure (BP) regulation in elderly people. It has been suggested that primarily the carbohydrate (CH) content of a meal induces the BP decrease. Therefore, we examined the relationship between the CH content of meals and postprandial BP responses in elderly patients diagnosed with PPH.
  
  
  METHODS
  Twelve geriatric patients (aged 75 to 91 years; 6 men) who were previously diagnosed with PPH received standardized liquid meals with low- (25 g), normal- (65 g), and high- (125 g) CH content in random order on three separate days. Systolic BP (SBP), diastolic BP, and heart rate were measured every 5 minutes from 20 minutes before until 75 minutes after each meal. Postprandial symptoms were recorded every 15 minutes.
  
  
  RESULTS
  The maximum decrease in SBP was significantly smaller after the low-CH meal (-28 +/- 5 mm Hg) than after the normal- (-39 +/- 7 mm Hg) and high-CH meals (-40 +/- 5 mm Hg) (p <.050 between groups). In addition, the duration of PPH was significantly shorter (p <.010), and postprandial symptoms were less frequent and less severe after the low-CH meal.
  
  
  CONCLUSIONS
  Reducing the CH amount in meals induces significantly smaller decreases in SBP, shorter duration of PPH, and reduction of PPH-related symptoms. Therefore, limiting the CH content of an elderly patient's meal can be a clinically effective nonpharmacological treatment for PPH in elderly patients and can reduce the risk of developing symptomatic PPH.
authors.affiliation: Department of Geriatric Medicine, University Medical Center Nijmegen, The Netherlands.
authors.forename: L C
authors.initials: LC
authors.lastname: Vloet
authors.forename: D J
authors.initials: DJ
authors.lastname: Mehagnoul-Schipper
authors.forename: W H
authors.initials: WH
authors.lastname: Hoefnagels
authors.forename: R W
authors.initials: RW
authors.lastname: Jansen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D003971:Diastole; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000209:etiology* / Q000503:physiopathology; D019518:Postprandial Period / Q000502:physiology*; D013599:Systole; D013997:Time Factors
chemical_list: D004040:Dietary Carbohydrates