Synthesis and antimicrobial activity of new 3 alpha-hydroxy-23,24-bisnorcholane polyamine carbamates.
3 alpha-Hydroxy-23,24-bisnorcholane spermidine and spermine carbamates 2-7 have been synthesized and their antimicrobial and hemolytic activities were evaluated. They exhibited excellent in vitro activities especially against methicillin-resistant Staphylococcus aureus.
Kim
H S
HS
Department of Industrial Chemistry, Kyungpook National University, Taegu 702-701, South Korea. kimhs@knu.ac.kr
Kwon
K C
KC
Kim
K S
KS
Lee
C H
CH
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D002219:Carbamates / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D011073:Polyamines / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D002219:Carbamates; D011073:Polyamines