[Study on the level of plasma calcitonin gene-related peptide and adrenomedullin in subjects with primary osteoporosis].
OBJECTIVE
To explore if there is any change of the level of plama CGRP and ADM in primary osteoporosis.


METHODS
75 female subjects complaining of back pain, aged from 34-70 years, were included in present study. The plasma level of CGRP and ADM was determined by radioimmunoassay. The bone mineral density (BMD) of lumber spine and hip of these patients was also examined by dual-energy X-ray absorptiometry (DEXA). According to the WHO osteoporosis criteria, these patients were divided into three groups: normal BMD (as control), osteopenia and osteoporosis.


RESULTS
Plasma level of CGRP and ADM of lumbar osteoporosis are 37 ng/L +/- 7 ng/L and 50 ng/L +/- 11 ng/L respectfully, while those of lumber osteopenia are 38 ng/L +/- 7 ng/L and 49 ng/L +/- 11 ng/L, they are significantly higher than those of normal lumber bone mineral density, which are 29 ng/L +/- 6 ng/L and 38 ng/L +/- 8 ng/L(F = 5.60 or 9.60, P < 0.05 or 0.01). The plasma level of ADM of hip and ward's osteoporosis (49 ng/L +/- 13 ng/L and 49 ng/L +/- 11 ng/L) is also higher than that of the control (F = 5.43 and 4.66, P < 0.05). Group of lumbar osteopenia also has higher level of CGRP and ADM than the control. (37 ng/L +/- 7 ng/L) and 38 ng/L +/- 6 ng/L, P < 0.05).


CONCLUSIONS
Plasma level of CGRP and ADM is significantly increased in subjects with osteoporosis. CGRP and ADM may play a role in the mechanism of etiology of primary osteoporosis.
Lin
J
J
Department of Orthopaedics, First Hospital of Peking University, Beijing 100034, China.
Lü
C
C
Gao
L
L
D053607:Adrenomedullin; D000328:Adult; D000368:Aged; D015519:Bone Density; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000209:etiology; D010455:Peptides / Q000097:blood*
D010455:Peptides; D053607:Adrenomedullin; D015740:Calcitonin Gene-Related Peptide