Chemo-, regio-, and diastereoselective synthesis of functionalized cyclopropanes by cyclization of dilithiated nitriles with epibromohydrin.
The cyclization of 1,1-dianions with epibromohydrin results in chemo-, regio-, and diastereoselective formation of functionalized hydroxymethyl cyclopropanes. [reaction: see text]
Langer
P
P
Institut für Organische Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany. planger@uni-goettingen.de
Freifeld
I
I