Facile metal-assisted hydrolysis of a urethane.
Kinetic studies demonstrate that it is possible to achieve large rate enhancements (2 x 10(4)) for the hydrolysis of a urethane group by using metal-bound water or hydroxide as the nucleophile. [reaction: see text]
Kelly
T R
TR
E. F. Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA. ross.kelly@bc.edu
Cavero
M
M
Zhao
Y
Y
D006868:Hydrolysis; D007700:Kinetics; D008670:Metals / Q000737:chemistry*; D014520:Urethane / Q000737:chemistry*
D008670:Metals; D014520:Urethane