title: Malignant transformation of multiple dermal cylindromas.
abstract: Cylindromas are benign tumours arising as small, solitary, slow-growing nodules on the head and neck. Multiple cylindromas may form a 'turban tumour' in the autosomal dominant Brooke-Spiegler syndrome. We report two unusual cases of multiple cylindromas with transformation into cylindrocarcinomas. The first patient, a 63-year-old white woman, developed a cylindrocarcinoma on pre-existing multiple cylindromas on her right shoulder. Eight months after resection she developed a lymph node metastasis in the right axilla. The second patient, a 68-year-old white woman, presented with multiple cylindromas of the scalp. One of these transformed into a cylindrocarcinoma, infiltrating the dura mater, with local recurrence 2 years after incomplete resection and postoperative radiation.
authors.affiliation: Department of Dermatology, University of Heidelberg, Voss-str. 2, 69115 Heidelberg, Germany.
authors.forename: B K
authors.initials: BK
authors.lastname: Durani
authors.forename: H
authors.initials: H
authors.lastname: Kurzen
authors.forename: A
authors.initials: A
authors.lastname: Jaeckel
authors.forename: N
authors.initials: N
authors.lastname: Kuner
authors.forename: H
authors.initials: H
authors.lastname: Naeher
authors.forename: W
authors.initials: W
authors.lastname: Hartschuh
mesh_terms: D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology* / Q000556:secondary; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D012535:Scalp; D012878:Skin Neoplasms / Q000473:pathology*