Quantitative structure-activity relationship of some HIV-1 protease inhibitors: a Fujita-Ban type analysis.
A Fujita-Ban type analysis has been made on a few series of HIV-1 (human immunodeficiency virus of type 1) protease inhibitors and the activity contributions of various substituents obtained. From these activity contributions, a compound is predicted that may have better activity than ritonavir, presently prescribed for the treatment of patients suffering from HIV-1. A few other compounds are also suggested.
Mekapati
S B
SB
Department of Chemistry, Pomona College, Claremont, CA 91711, USA.
Sivakumar
R
R
Gupta
S P
SP
D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D015195:Drug Design; D015658:HIV Infections / Q000188:drug therapy; D016333:HIV Protease / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship; D019438:Ritonavir / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects
D017320:HIV Protease Inhibitors; D011725:Pyridines; C092970:A 80987; D016333:HIV Protease; D019438:Ritonavir