Fatal myocarditis associated with acute parvovirus B19 and human herpesvirus 6 coinfection.
We report on the case of a healthy young boy who developed a fulminant myocarditis due to acute coinfection with erythrovirus (parvovirus B19) and human herpesvirus 6 (HHV-6) in the absence of an antiviral immune response. We suggest that the HHV-6-induced immunosuppression enhanced dissemination of parvovirus B19, which led to fatal myocarditis.
Rohayem
J
J
Institut für Virologie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Dinger
J
J
Fischer
R
R
Klingel
K
K
Kandolf
R
R
Rethwilm
A
A
D000208:Acute Disease; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D016731:Erythema Infectiosum / Q000150:complications* / Q000821:virology; D017809:Fatal Outcome; D006566:Herpesviridae Infections / Q000150:complications* / Q000821:virology; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009205:Myocarditis / Q000821:virology*; D016732:Parvovirus B19, Human / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
D004279:DNA, Viral