[Evaluation of usefulness of touch smear cytology for the diagnosis of Helicobacter pylori infection].
The aim of this study was to assess the utility of the touch smear cytology for the detection of Helicobacter pylori (H. pylori) infection compared with biological culture, immunohistochemistry and rapid urease test. 1) The diagnostic concordance rate of touch smear cytology compared with both immunohistochemistry and biological culture of the same specimen were 94.2% and 93.8%, respectively. Diagnosis using the touch smear cytology had no statistically significant relation with numbers of H. pylori in the samples determined by immunohistochemistry. 2) Compared with biologic culture, the sensitivity and specificity of rapid urease test were 85.0% and 96.3%, and that of touch smear cytology were 91.2%, 96.3%, respectively. 3) Two biopsies were taken from each lesion (all the patients had two lesions; at the body and antrum) and examined using touch smear cytology. In all the positive lesions, the two biopsies were positive and p value concerning the numbers of H. pylori was significant. In conclusion, touch smear cytology is considered to be one of the reliable methods for the detection of H. pylori infection because of its high accuracy rate, convenience, rapidity, low cost and stability.
Yamamoto
T
T
Second Department of Internal Medicine, Kagoshima University.
D001431:Bacteriological Techniques; D016481:Helicobacter Infections / Q000175:diagnosis / Q000382:microbiology*; D016480:Helicobacter pylori; D006801:Humans; D012680:Sensitivity and Specificity