Aldose reductase inhibitors from the fruits of Caesalpinia ferrea Mart.
Aldose reductase inhibitors were isolated from an extract of the dry fruits of Caesalpinia ferrea Mart. (Leguminosae). Compound 2 was identified as ellagic acid by comparison with a reference sample. The structure of compound 1 was elucidated as 2-(2,3,6-trihydroxy-4-carboxyphenyl) ellagic acid on the basis of spectral evidence, especially 2D-NMR data (HMQC, HMBC and NOESY). These two compounds inhibited aldose reductase in a non-competitive manner.
Ueda
H
H
Kobe Pharmaceutical University, Japan.
Tachibana
Y
Y
Moriyasu
M
M
Kawanishi
K
K
Alves
S M
SM
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D029911:Caesalpinia; D004610:Ellagic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000494:pharmacology*; D012015:Reference Standards
C451101:2-(2,3,6-trihydroxy-4-carboxyphenyl) ellagic acid; D010936:Plant Extracts; D004610:Ellagic Acid; D000449:Aldehyde Reductase