[Current features of food allergies: the need of allergy surveillance].
The prevalence of food allergy in European populations has been evaluated at between 1.8 and 4.4%. In the French population it is 3.24%. This frequency, as well as the gravity of some manifestations, has already led to preventive and curative measures being taken in school settings. This increase is related to multiple environmental factors: changes in intestinal microflora, early diversification of foods in children, interference of drugs favoring clinical severity in adults. Allergenicity can be modified by food industry techniques. The appearance of novel foods (exotic proteins or those derived from animal feed, and soon GMOs), the growing use of food proteins as ingredients, constitute new risks. The absence of validated experimental methods for evaluating the allergic risk of food proteins makes it necessary to implement a policy of allergy vigilance for novel foods. Studies concerning the allergic risk for lupin flour, a new ingredient used in baked goods, are given as an example. They indicate the frequency of sensitization and cross peanut-lupin flour allergy, the low reactive threshold, indicating the risk of the level of incorporation presently allowed. They make possible current screening for this allergy in the population. Allergy vigilance is a recent concept that aims to set up surveillance of food allergy risks in a manner analogous to that of pharmacovigilance for drugs. A project for creating such a structure is being discussed. Although the central structure remains at the initiative of the Agence Française de Sécurité Sanitaire de l'Alimentation (French Agency for Food Safety) and the Institut de Veille Sanitaire (Institute of Health) the authors specify what a peripheral network of allergists should be, analyze the desired content of the bi-directional flow of information, and propose envisaging an intermediate regulatory organization, specialized in the diagnosis and treatment of food allergies. The ongoing idea is that environmental pressures on the genetics of atopic disease lead to a continuum of IgE-dependent responses towards all the potential allergens in the entire population. Consequently, the creation of such a structure is advised in the name of the Precautionary Principle.
Moneret-Vautrin
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Service de Médecine Interne-Immunologie Clinique et Allergologie, CHU de Nancy-Hôpital Central, Avenue de Lattre de Tassigny-54035 Nancy.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance