title: No alteration in serum leptin levels during acute endotoxemia in sheep.
abstract: To determine the role of leptin in endotoxin-induced anorexia in ruminants, circulating leptin levels were measured during acute experimental endotoxemia in sheep. Injection of bacterial lipopolysaccharide (450 ng/kg, i.v.) induced anorexia accompanied with fever and increases in serum levels of cortisol, insulin and glucose which are known to stimulate leptin secretion in rodent and human, while it did not affect serum leptin levels at all. These results indicate that serum leptin levels in sheep during acute endotoxemia are differentially regulated from those in rodent and human, and that leptin might not be involved in the endotoxin-induced anorexia in sheep.
authors.affiliation: Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Soliman
authors.forename: S
authors.initials: S
authors.lastname: Abdelhady
authors.forename: I
authors.initials: I
authors.lastname: Fattouh
authors.forename: K
authors.initials: K
authors.lastname: Ishioka
authors.forename: H
authors.initials: H
authors.lastname: Kitamura
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Saito
mesh_terms: D000208:Acute Disease; D000818:Animals; D000855:Anorexia / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D001786:Blood Glucose / Q000032:analysis; D004435:Eating; D019446:Endotoxemia / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008070:Lipopolysaccharides / Q000008:administration & dosage; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood* / Q000473:pathology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D008070:Lipopolysaccharides; D006854:Hydrocortisone