title: A study of the efficacy of topical and systemic therapy for the treatment of feline Microsporum canis infection.
abstract: Microsporum canis infection was induced in 21 healthy SPF-derived cats. Once infection was established (4 weeks after inoculation) the cats were divided into three equal groups housed in separate rooms and monitored for 16 weeks. During this time, group A cats received oral griseofulvin at approximately 50 mg/kg daily and were shampooed twice weekly with a product containing chlorhexidine and miconazole. Group B cats were treated with griseofulvin alone, and group C cats served as untreated controls. The cats were examined on a weekly basis and the severity of lesions was scored semi-quantitatively. In addition, hair samples were collected from each cat on a weekly basis by the MacKenzie brush technique and by the sticky-tape method. A semi-quantitative scoring system was also used for the assessment of fungal (M canis) growth. Generally, significant differences in clinical scores were not seen between the groups although at weeks 3, 4 and 11 there was a significant difference (P< or =0.015) with cats in group A having significantly lower median scores than those in group C. Median times to clinical resolution (return of clinical scores to zero) in groups A, B and C were at treatment weeks 2, 9 and 12, respectively (P>0.05). Median times for mycological resolution (persistently negative culture results) for groups A, B and C were at treatment weeks 2, 9 and 12, respectively, for the MacKenzie brush technique and at weeks 4, 8 and 12 for the sticky-tape technique. For both these results, the groups differed significantly (P< or =0.001) and in both instances group A had significantly more rapid resolution than groups B or C. Median culture scores were significantly different between the three groups using one or both of the sampling techniques at week 2 through to week 12 of treatment with median scores for either group A alone, or groups A and B being significantly lower than group C (P< or =0.026). These results showed a benefit from the addition of twice-weekly chlorhexidine-miconazole shampooing to systemic griseofulvin therapy alone in the treatment of M canis infected cats.
authors.affiliation: The Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, CB8 7UU.
authors.forename: A H
authors.initials: AH
authors.lastname: Sparkes
authors.forename: A
authors.initials: A
authors.lastname: Robinson
authors.forename: A D
authors.initials: AD
authors.lastname: MacKay
authors.forename: S E
authors.initials: SE
authors.lastname: Shaw
authors.forename: S E
authors.initials: SE
authors.lastname: Shau
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002371:Cat Diseases / Q000188:drug therapy* / Q000382:microbiology; D002415:Cats; D002710:Chlorhexidine / Q000008:administration & dosage / Q000494:pharmacology; D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D004359:Drug Therapy, Combination; D005260:Female; D006118:Griseofulvin / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008825:Miconazole / Q000008:administration & dosage / Q000494:pharmacology; D008864:Microsporum / Q000187:drug effects / Q000254:growth & development; D011897:Random Allocation; D012867:Skin / Q000473:pathology; D013047:Specific Pathogen-Free Organisms; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D006118:Griseofulvin; D008825:Miconazole; D002710:Chlorhexidine