Development of hypertensive status in NISAG rats reared by normotensive Wistar rats.
Parameters of the cardiovascular system and the content of corticosterone, thyrotrophin, thyroxin, and triiodothyronine in the plasma, and norepinephrine in the myocardium were determined in male NISAG rats (hereditary stress-induced arterial hypertension) reared by normotensive Wistar rats. Cross-rearing of hypertensive rat pups by normotensive females attenuated arterial hypertension with a tendency to normalization of the examined parameters. This confirms the possibility of modifying hypertensive phenotype by changing the conditions of the early postnatal development.
Yakobson
G S
GS
Institute of Physiology, Siberian Division of the Russian Academy of Medical Science.
Antonov
A R
AR
Markel'
A L
AL
Amstislavskii
S Y
SY
Taranov
A G
AG
Yakobson
M G
MG
D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure; D003345:Corticosterone / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine; D003345:Corticosterone; D009638:Norepinephrine