title: Proton MRI of (13)C distribution by J and chemical shift editing.
abstract: The sensitivity of (13)C NMR imaging can be considerably favored by detecting the (1)H nuclei bound to (13)C nuclei via scalar J-interaction (X-filter). However, the J-editing approaches have difficulty in discriminating between compounds with similar J-constant as, for example, different glucose metabolites. In such cases, it is almost impossible to get J-edited images of a single-compound distribution, since the various molecules are distinguishable only via their chemical shift. In a recent application of J-editing to high-resolution spectroscopy, it has been shown that a more efficient chemical selectivity could be obtained by utilizing the larger chemical shift range of (13)C. This has been made by introducing frequency-selective (13)C pulses that allow a great capability of indirect chemical separation. Here a double-resonance imaging approach is proposed, based on both J-editing and (13)C chemical shift editing, which achieves a powerful chemical selectivity and is able to produce full maps of specific chemical compounds. Results are presented on a multicompartments sample containing solutions of glucose and lactic and glutamic acid in water.
authors.affiliation: INFM and Department of Physics, University of L'Aquila, I-67100 L'Aquila, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Casieri
authors.forename: C
authors.initials: C
authors.lastname: Testa
authors.forename: G
authors.initials: G
authors.lastname: Carpinelli
authors.forename: R
authors.initials: R
authors.lastname: Canese
authors.forename: F
authors.initials: F
authors.lastname: Podo
authors.forename: F
authors.initials: F
authors.lastname: De Luca