title: [Use of immunomodulators isolated from marine invertebrates for reducing the toxic effects of thermostable toxin and lipopolysaccharides from Yersinia pseudotuberculosis on a macroorganism].
abstract: The possibility to use immunomodulators isolated from marine invertebrates for the lowering of the toxic effects caused by Yersinia pseudotuberculosis thermoresistant toxin and lipopolysaccharide was investigated. Effects were evaluated by the animals survival rate in per cent and mice average lifetime after toxin lethal dose injection. It was shown that polypeptide gangleen when compared to timalin as well as glycanes mitilane and strombus had dose-dependent protective effect. These substances increased animals survival rate to 15-17 per cent and prolonged life period for about two times when compared to control group. These results demonstrates the possibility to use investigated immunomodulators is clinical practice at the treatment of the patients with pseudotuberculosis.
authors.affiliation: Research Institute of Epidemiology and Microbiology, Siberian Branch of the Russian Academy of Medical Sciences, Vladivostok.
authors.forename: T A
authors.initials: TA
authors.lastname: Kuznetsova
authors.forename: A A
authors.initials: AA
authors.lastname: Logvinenko
authors.forename: N F
authors.initials: NF
authors.lastname: Timchenko
authors.forename: L M
authors.initials: LM
authors.lastname: Epshteĭn
authors.forename: N N
authors.initials: NN
authors.lastname: Besednova
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D008974:Mollusca; D011134:Polysaccharides / Q000627:therapeutic use*; D015011:Yersinia pseudotuberculosis
chemical_list: D000276:Adjuvants, Immunologic; D001427:Bacterial Toxins; D008070:Lipopolysaccharides; D011134:Polysaccharides