title: Chemokine receptor dimerization: two are better than one.
abstract: The chemokines participate in an exceptional range of physiological and pathological processes, including the control of lymphocyte trafficking, tumor growth, wound healing, allograft rejection, regulation of T-cell differentiation, asthma, infection with HIV and atherosclerosis. This vast array of activities is triggered by the interaction of nearly 50 different chemokines with a relatively modest number of 20 G-protein-coupled receptors. The asymmetry between the number of receptors and ligands suggests an underlying, shared control mechanism activated at a very early stage of the response. One of the first events triggered by the binding of chemokines is the homo- and hetero-dimerization of their receptors; here, we outline these events and their consequences in chemokine signaling.
authors.affiliation: Dept of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, UAM Campus de Cantoblanco, E-28049 Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez-Frade
authors.forename: M
authors.initials: M
authors.lastname: Mellado
authors.forename: C
authors.initials: C
authors.lastname: Martínez-A
mesh_terms: D000818:Animals; D018925:Chemokines / Q000378:metabolism*; D019281:Dimerization; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D019707:Receptors, Chemokine / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine; D019000:Phosphotyrosine; D019869:Phosphatidylinositol 3-Kinases; D011505:Protein-Tyrosine Kinases; D020962:Heterotrimeric GTP-Binding Proteins