Case-Control study of the extended tau gene haplotype in Parkinson's disease.
We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98-2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.
Maraganore
D M
DM
Department of Neurology Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. dmaraganore@mayo.edu
Hernandez
D G
DG
Singleton
A B
AB
Farrer
M J
MJ
McDonnell
S K
SK
Hutton
M L
ML
Hardy
J A
JA
Rocca
W A
WA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005060:Europe / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D018570:Risk Assessment; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins