Multidrug resistant Mycobacterium leprae from patients with leprosy.
Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae.
Maeda
S
S
Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002, Japan.
Matsuoka
M
M
Nakata
N
N
Kai
M
M
Maeda
Y
Y
Hashimoto
K
K
Kimura
H
H
Kobayashi
K
K
Kashiwabara
Y
Y
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000494:pharmacology / Q000627:therapeutic use; D001483:Base Sequence; D017931:DNA Primers; D004269:DNA, Bacterial / Q000187:drug effects / Q000235:genetics; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005798:Genes, Bacterial / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007917:Leprostatic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy* / Q000382:microbiology*; D051379:Mice; D008969:Molecular Sequence Data; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000235:genetics; D015242:Ofloxacin / Q000494:pharmacology / Q000627:therapeutic use; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use
D000890:Anti-Infective Agents; D000904:Antibiotics, Antitubercular; D017931:DNA Primers; D004269:DNA, Bacterial; D007917:Leprostatic Agents; D015242:Ofloxacin; D012293:Rifampin