Cardiac surgery in patients with protamine allergy.
Intravenous administration of protamine is associated with risk of severe anaphylactic and anaphylactoid reactions. In this review the incidence, pathophysiology, clinical management, and strategies for prevention of protamine reactions are addressed.
Ravi
R
R
New York Medical College, Valhalla, New York 10595, USA.
Frost
E A
EA
D000465:Algorithms; D006348:Cardiac Surgical Procedures; D004342:Drug Hypersensitivity / Q000209:etiology*; D006494:Heparin Antagonists / Q000009:adverse effects*; D006801:Humans; D011479:Protamines / Q000009:adverse effects*; D012307:Risk Factors
D006494:Heparin Antagonists; D011479:Protamines