Vilsmeier formylation of 2-carboxyindoles and preparation of O-benzylhydroxyureas on solid phase.
The Vilsmeier formylation has been introduced for the solid-phase functionalization of five different 2-carboxyindoles. The aldehyde functionality has been utilized in the preparation of O-benzylhydroxyureas.
Tois
J
J
Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Helsinki, P.O. Box 56, FIN-00014, Helsinki, Finland. Jan.Tois@helsinki.fi
Franzèn
R
R
Aitio
O
O
Laakso
I
I
Kylänlahti
I
I
D002264:Carboxylic Acids / Q000138:chemical synthesis; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D005561:Formates / Q000737:chemistry; D006918:Hydroxyurea / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*; D013678:Technology, Pharmaceutical; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D002264:Carboxylic Acids; D005561:Formates; D007211:Indoles; C030544:formic acid; D014508:Urea; D006918:Hydroxyurea