title: [Four levels (types) of immune reponse in children with viral parotitis infections].
abstract: Four levels (types) of immune response, differing by expression of cytokines (TNF-alpha, IL-1 beta, IL-4, and gamma-IFN) and immunoglobulins IgG2, IgG3, IgG4, and IgE) and by expression and time course of specific cell-mediated and humoral immune response, were detected in children with different clinical forms of mumps. Types 1 and 3 immune response are predominantly cell-mediated, while types 2 and 4 predominantly humoral during the acute phase of the disease. The cytokine and antigen-specific profiles of each type of immune response correlate with the severity of clinical course of mumps.
authors.forename: G F
authors.initials: GF
authors.lastname: Zheleznikova
authors.forename: V V
authors.initials: VV
authors.lastname: Ivanova
authors.forename: M K
authors.initials: MK
authors.lastname: Bekhtereva
authors.forename: N E
authors.initials: NE
authors.lastname: Monakhova
authors.forename: E V
authors.initials: EV
authors.lastname: Novozhilova
authors.forename: O V
authors.initials: OV
authors.lastname: Goleva
authors.forename: A N
authors.initials: AN
authors.lastname: Sizemov
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis*; D002648:Child; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000096:biosynthesis / Q000145:classification; D009107:Mumps / Q000276:immunology* / Q000473:pathology; D009109:Mumps virus / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D016207:Cytokines; D007136:Immunoglobulins