The role of tissue factor/factor VIIa in the pathophysiology of acute thrombotic formation.
Tissue factor (TF) is the essential cofactor for the coagulation protease factor VIIa (FVIIa), initiating the coagulation cascade. The role of TF in thrombotic diseases is becoming increasingly evident. Recent findings suggest that inhibition of TF/FVIIa activity could be important in the prevention of clinical sequelae associated with plaque rupture or vessel damage that exposes TF to blood. Furthermore, selective inhibitors of TF/FVIIa may be associated with less bleeding risk than other antithrombotic agents. Several TF/FVIIa inhibitors are in development, including the protein-based inhibitors (such as NAPc2, Corsevin M, FFR-FVIIa, and Tifacogin). Research into the development of small molecule inhibitors is on-going, but is at a less advanced stage.
Girard
T J
TJ
Pharmacia Corporation, Creve Coeur, Missouri 63167, USA. thomas.j.girard@pharmacia.com
Nicholson
N S
NS
D000208:Acute Disease; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003328:Coronary Thrombosis / Q000188:drug therapy / Q000378:metabolism*; D005167:Factor VII / Q000502:physiology; D015942:Factor VIIa / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015801:Helminth Proteins / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D011506:Proteins / Q000494:pharmacology / Q000627:therapeutic use; D013925:Thromboplastin / Q000037:antagonists & inhibitors / Q000502:physiology*
D000911:Antibodies, Monoclonal; D000925:Anticoagulants; D005343:Fibrinolytic Agents; D015801:Helminth Proteins; D011506:Proteins; C400226:anti-coagulant protein C2, Ancylostoma caninum; C427263:phenylalanyl-phenylalanyl-arginyl-recombinant FVIIa; C400709:Tifacogin; D005167:Factor VII; D013925:Thromboplastin; D015942:Factor VIIa