title: QSAR studies on some antimalarial sulfonamides.
abstract: Antimalarial activity of a series of sulfonamide derivatives (2,4-diamino-6-quinazoline sulfonamides) was modeled topologically using Wiener (W)-, and Szeged (Sz)-indices. The regression analysis of the data has shown that better results are obtained in multiparametric regressions upon introduction of indicator parameters. Predicting ability of the models was tested by r(2)(cv) values. It was observed that models based on W index gave slightly better results than those in which Sz is involved.
authors.affiliation: Department of Chemistry, A.P.S. University, Rewa-486 003, India. vijay-agrawal@lycos.com
authors.forename: V K
authors.initials: VK
authors.lastname: Agrawal
authors.forename: R
authors.initials: R
authors.lastname: Srivastava
authors.forename: P V
authors.initials: PV
authors.lastname: Khadikar
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D021281:Quantitative Structure-Activity Relationship; D012044:Regression Analysis; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D013449:Sulfonamides