Endothelial dysfunction in patients with polycythaemia vera.
Patients with polycythaemia vera (PV) are at increased risk of developing arterial and venous thromboembolic complications. We investigated whether endothelium-dependent, flow-mediated vasodilatation (FMD) is impaired in PV patients without clinical evidence of artery disease as observed in patients with conventional cardiovascular risk factors. FMD and endothelium-independent, nitroglycerine-induced vasodilatation (NMD) were assessed using high-resolution ultrasound in the brachial artery of 20 patients with PV and 20 sex- and age-matched control subjects (CTL). FMD was markedly impaired in PV patients compared with CTL (7.6 +/- 2.9% versus 11.6 +/- 5.7%, P = 0.009) whereas NMD was similar in both study groups. The impairment of FMD was independently related to the presence of PV (r = -0.434, P = 0.009) and vessel size (r = -0.107, P = 0.038) but was not related to haematocrit values and platelet counts. The results demonstrate that PV is associated with endothelial dysfunction in the pre-clinical phase of arterial disease. However, the precise mechanisms by which PV leads to this altered vascular reactivity remain unclear.
Neunteufl
T
T
Department of Cardiology, University of Vienna, Vienna, Austria. thomas.neunteufl@univie.ac.at
Heher
S
S
Stefenelli
T
T
Pabinger
I
I
Gisslinger
H
H
D000328:Adult; D000368:Aged; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin; D011087:Polycythemia Vera / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012307:Risk Factors; D014463:Ultrasonography; D014664:Vasodilation / Q000502:physiology*; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D005996:Nitroglycerin