Deep brain stimulation (DBS) attentional effects parallel those of l-dopa treatment.
Aim of our study was to investigate the different effects on attentional capacity of deep brain stimulation DBS (STN or GPi) and of l-dopa in PD patients. Patients were evaluated on-DBS/off-l-dopa, on-l-dopa/off-DBS, on-l-dopa/on-DBS and off-l-dopa/off-DBS. Our results indicate that DBS effects on attentional functions parallel those of l-dopa. A site independent (both STN and GPi) worsening of verbal fluency was observed, possibly connected to the stimulus effect on the cortico-subcortical-cortical loop.
Brusa
L
L
IRCCS Fondazione S. Lucia, and Clinica Neurologica, Universita' degli Studi di Roma Tor Vergata, Italy.
Pierantozzi
M
M
Peppe
A
A
Altibrandi
M G
MG
Giacomini
P
P
Mazzone
P
P
Stanzione
P
P
D000328:Adult; D001288:Attention / Q000187:drug effects / Q000502:physiology*; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004599:Electric Stimulation Therapy / Q000009:adverse effects* / Q000379:methods / Q000523:psychology; D005917:Globus Pallidus / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000188:drug therapy* / Q000523:psychology / Q000601:surgery*; D013064:Speech Disorders / Q000209:etiology / Q000503:physiopathology; D020531:Subthalamic Nucleus / Q000187:drug effects / Q000503:physiopathology*
D007980:Levodopa