title: Apolipoprotein E and age at onset of Alzheimer's disease in African American patients.
abstract: The authors examined whether the APOE-epsilon4 allele is associated with an earlier age at onset of AD in 71 African American patients with probable AD. The authors found a linear dose effect in which each copy of the epsilon4 allele was associated with a 3.6-year earlier onset of AD, indicating a dose-dependent relationship between APOE-epsilon4 and age at onset of AD in African Americans.
authors.affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, GA 30329, USA. fgoldst@emory.edu
authors.forename: F C
authors.initials: FC
authors.lastname: Goldstein
authors.forename: A V
authors.initials: AV
authors.lastname: Ashley
authors.forename: M
authors.initials: M
authors.lastname: Gearing
authors.forename: J
authors.initials: J
authors.lastname: Hanfelt
authors.forename: L
authors.initials: L
authors.lastname: Penix
authors.forename: L J
authors.initials: LJ
authors.lastname: Freedman
authors.forename: A I
authors.initials: AI
authors.lastname: Levey
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D005260:Female; D018628:Gene Dosage; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D001741:Black or African American
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E