[Induction of cytogenetic damages by combined action of heavy metal salts, chronic and acute gamma irradiation in bone marrow cells of mice and rats].
The aim of the present work was to study the combined action of salts of heavy metals (lead and cadmium), and acute and chronic gamma-irradiation on the cytogenetic damage to bone marrow cells of rats and mice. It was shown that the chronic exposure of rats and mice in vivo to gamma-irradiation induced the adaptive response. The salts of heavy metals supplemented to the diet of rats enhanced the cytogenetic damage to the non-irradiated animals, slightly enhanced the effect of chronic and acute gamma-irradiation, decreased the cytogenetic adaptive response induced by chronic gamma-irradiation.
Zaichkina
S I
SI
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Russia. Zaichkina@mail.ru
Rozanova
O M
OM
Aptikaeva
G F
GF
Akhmadieva
A Kh
AKh
Klokov
D Iu
DIu
Smirnova
E N
EN
D000222:Adaptation, Physiological; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects*; D002104:Cadmium / Q000633:toxicity; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects* / Q000528:radiation effects*; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D007854:Lead / Q000633:toxicity; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D019216:Metals, Heavy / Q000633:toxicity*; D051379:Mice; D015162:Micronucleus Tests; D011817:Rabbits; D011829:Radiation Dosage; D051381:Rats; D013997:Time Factors
D019216:Metals, Heavy; D002104:Cadmium; D007854:Lead