title: Koala biovar of Chlamydia pneumoniae infects human and koala monocytes and induces increased uptake of lipids in vitro.
abstract: We examined the ability of the koala biovar of Chlamydia pneumoniae to infect both Hep-2 cells and human monocytes and the effect of infection on the formation of foam cells. The koala biovar produced large inclusions in both human and koala monocytes and in Hep-2 cells. Koala C. pneumoniae induced foam cell formation with and without added low-density lipoprotein, in contrast to TW183, which produced increased foam cell formation only in the presence of low-density lipoprotein.
authors.affiliation: Departments of Public Health, the University of Western Australia. k.coles@ugrad.unimelb.edu
authors.forename: K A
authors.initials: KA
authors.lastname: Coles
authors.forename: P
authors.initials: P
authors.lastname: Timms
authors.forename: D W
authors.initials: DW
authors.lastname: Smith
mesh_terms: D000818:Animals; D001692:Biological Transport; D002454:Cell Differentiation; D002478:Cells, Cultured; D016993:Chlamydophila pneumoniae / Q000472:pathogenicity*; D005487:Foam Cells / Q000166:cytology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008394:Marsupialia / Q000382:microbiology*; D009000:Monocytes / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology*; D013045:Species Specificity
chemical_list: D008077:Lipoproteins, LDL