Extranodal cytotoxic T-cell lymphoma in a patient with X-linked agammaglobulinaemia.
This report documents the occurrence of an extranodal cytotoxic peripheral T-cell lymphoma (PTCL) in a patient with X-linked agammaglobulinaemia (XLA). The diagnosis was based on the immunohistochemical detection of T-cell antigens and of the cytotoxic proteins TIA1 and Granzyme B in the tumour cells. This report provides further evidence that cytotoxic lymphomas are part of the differential diagnosis of neoplasia in patients with immunodeficiencies.
Kanavaros
P
P
Department of Histology, Medical Faculty, University of Thessalia, Hellas.
Rontogianni
D
D
Hrissovergi
D
D
Efthimiadoy
A
A
Argyrakos
T
T
Mastoris
K
K
Stefanaki
K
K
D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000235:genetics; D053804:Granzymes; D006801:Humans; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins / Q000032:analysis; D012697:Serine Endopeptidases / Q000032:analysis; D000074019:T-Cell Intracellular Antigen-1; D013602:T-Lymphocytes, Cytotoxic / Q000473:pathology*; D014960:X Chromosome
D008565:Membrane Proteins; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases