L-arginine infusion lowers blood pressure in children.
Eleven children were studied during L-arginine infusion. Blood pressure decreased, and mean plasma L-arginine and L-citrulline increased compared with baseline levels. The change in blood pressure was inversely related to the change in plasma L-citrulline. These results suggest that L-arginine decreased blood pressure via increased nitric oxide production.
Nelin
L D
LD
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Hoffman
G M
GM
D000293:Adolescent; D001120:Arginine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007262:Infusions, Intravenous; D009569:Nitric Oxide / Q000097:blood
D009569:Nitric Oxide; D001120:Arginine