[Comparative evaluation of neurovirulence of domestic and foreign live mumps vaccine].
Morphological and immunofluorescent study of changes in the central nervous system of monkeys with mumps was carried out in order to determine the criteria of neurovirulence of different mumps virus strains. Quantitative evaluation showed a lower residual neurovirulence of L-3 strain vs. Jeryl Lynn and Urabe Am9 strains. Use of new methodological approaches to evaluation of mumps vaccine strain neurovirulence will improve the safety control of live mumps vaccines.
Maksimova
O A
OA
Popov
V F
VF
Bektimirov
T A
TA
Grigor'eva
L V
LV
Iunasova
T N
TN
Kaplunova
O P
OP
Sharova
O K
OK
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002522:Chlorocebus aethiops; D005455:Fluorescent Antibody Technique; D008253:Macaca mulatta; D009108:Mumps Vaccine / Q000009:adverse effects* / Q000276:immunology; D009422:Nervous System Diseases / Q000821:virology*; D013045:Species Specificity; D014774:Virulence
D000914:Antibodies, Viral; D009108:Mumps Vaccine