title: The coupling of cell growth to the cell cycle.
abstract: The development of a complex multicellular organism requires a coordination of growth and cell division under the control of patterning mechanisms. Studies in yeast have pioneered our understanding of the relationship between growth and cell division. In recent years, many of the pathways that regulate growth in multicellular eukaryotes have been identified. This work has revealed interesting and unexpected relationships between mechanisms that regulate growth and the cell cycle machinery.
authors.affiliation: Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA.
authors.forename: N
authors.initials: N
authors.lastname: Tapon
authors.forename: K H
authors.initials: KH
authors.lastname: Moberg
authors.forename: I K
authors.initials: IK
authors.lastname: Hariharan
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D004330:Drosophila / Q000166:cytology / Q000254:growth & development*; D007328:Insulin / Q000502:physiology; D008954:Models, Biological; D011518:Proto-Oncogene Proteins / Q000502:physiology; D012097:Repressor Proteins / Q000502:physiology; D015398:Signal Transduction; D015003:Yeasts / Q000166:cytology / Q000254:growth & development*
chemical_list: D016213:Cyclins; D007328:Insulin; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D018844:Cyclin-Dependent Kinases