title: Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XVII. Derivatives of 1-ethoxybicyclo[2.2.2]-oct-5-one-2,3-dicarboximide.
abstract: The preparation of a number of derivatives of 1-ethoxybicyclo[2.2.2]-oct-5-one-2,3-dicarboximide with potential anxiolytic activity has been described. The aim of our study was to obtain new analogs of tandospirone.
authors.affiliation: Katedra i Zaklad Chemii Medycznej, Akademia Medyczna w Warszawie, Warsaw, Poland. jkossako@bibl.amwaw.edu.pl
authors.forename: J
authors.initials: J
authors.lastname: Kossakowski
authors.forename: M
authors.initials: M
authors.lastname: Jarocka
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D014151:Anti-Anxiety Agents; D006844:Hydrocarbons, Cyclic; D007094:Imides