Aging and oxidative stress: studies of some genes involved both in aging and in response to oxidative stress.
Aging is a complex physiological phenomenon and several theories have been developed about its origin. Among such theories, the 'mitochondrial theory of aging' has been supported by numerous studies and reviews. Cell oxidative damage, in particular the accumulation of mtDNA mutations, is determined by the rate of reactive oxygen species production and degradation induced by the antioxidant defense systems. In this review, data from our laboratory and from the recent literature have been examined to provide arguments that reinforce the crucial role of mitochondria in aging. Various genes that affect life span have been described in numerous organisms. Some of them encode signal transduction proteins and participate in the regulation of mitochondrial metabolism.
Camougrand
N
N
Institut de Biochimie et Genetique Cellulaires du CNRS, 1 rue Camille Saint Saëns, 33077 Cedex, Bordeaux, France. n.camougrand@ibgc.u-bordeaux2.fr
Rigoulet
M
M
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D000375:Aging / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D054407:Chemokine CCL4; D019742:Chemokines, CC; D015870:Gene Expression / Q000502:physiology; D019402:Macrophage Inflammatory Proteins; D008928:Mitochondria / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics*; D000091402:Prohibitins; D011506:Proteins / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism; D012097:Repressor Proteins; D055765:Shc Signaling Adaptor Proteins; D018631:ras Proteins / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; C066507:CCL4 protein, human; D054407:Chemokine CCL4; D019742:Chemokines, CC; D019402:Macrophage Inflammatory Proteins; D000091402:Prohibitins; D011506:Proteins; D017382:Reactive Oxygen Species; D012097:Repressor Proteins; D055765:Shc Signaling Adaptor Proteins; D018631:ras Proteins