title: Latanoprost-induced iris heterochromia and open-angle glaucoma: a clinicopathologic report.
abstract: OBJECTIVE
  To report the histopathologic and immunohistochemical findings from the iridectomy specimen of a patient with acquired unilateral iris heterochromia due to latanoprost.
  
  
  METHODS
  A 45-year-old woman with open-angle glaucoma and unilateral iris heterochromia was evaluated for uncontrolled intraocular pressure increase. Subsequently, the patient underwent trabeculectomy with mitomycin C and an iridectomy specimen was obtained for analysis.
  
  
  RESULTS
  The histopathologic analysis of the iridectomy specimen did not reveal any nuclear atypia, nuclear crowding, or mitotic figures. Immunohistochemical studies showed that the iris melanocytes were negative for HMB45 and S-100, and weakly positive for Melan A.
  
  
  CONCLUSIONS
  Latanoprost-associated iris color change may exhibit a diffuse, uniform, dark velvet-brown appearance, thereby simulating diffuse iris melanoma. Histopathologic and immunohistochemical analysis confirmed the benign characteristics of the affected iris melanocytes.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Tsai
authors.forename: J A
authors.initials: JA
authors.lastname: Sivak-Callcott
authors.forename: B G
authors.initials: BG
authors.lastname: Haik
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: I W
authors.initials: IW
authors.lastname: McLean
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007498:Iris / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D007499:Iris Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D000077338:Latanoprost; D008548:Melanosis / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects* / Q000627:therapeutic use; D014130:Trabeculectomy
chemical_list: D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D016685:Mitomycin; D000077338:Latanoprost