title: Antiganglioside antibodies in polyneuropathy associated with monoclonal gammopathy.
abstract: Antibody reactivity to GA1, GM1, GM2, GD1a, GD1b, and GQ1b gangliosides was measured in 87 patients with polyneuropathy associated with monoclonal gammopathy (60 IgM, 25 IgG, 2 IgA) and 42 control patients with monoclonal gammopathy without polyneuropathy (21 IgM, 21 IgG). Of these 87 patients, 30% had anti-myelin-associated glycoprotein antibodies and 15% had antiganglioside antibodies. Antiganglioside antibodies were significantly associated with demyelinating neuropathy and with IgM monoclonal gammopathy. Anti-GD1b and anti-GQ1b antibodies were significantly associated with predominantly sensory ataxic neuropathy.
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Eurelings
authors.forename: C W
authors.initials: CW
authors.lastname: Ang
authors.forename: N C
authors.initials: NC
authors.lastname: Notermans
authors.forename: P A
authors.initials: PA
authors.lastname: Van Doorn
authors.forename: B C
authors.initials: BC
authors.lastname: Jacobs
authors.forename: L H
authors.initials: LH
authors.lastname: Van den Berg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D004576:Electromyography; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010265:Paraproteinemias / Q000175:diagnosis / Q000276:immunology*; D011115:Polyneuropathies / Q000175:diagnosis / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; D007075:Immunoglobulin M