Association analysis for dopamine D2 receptor Taq1 polymorphism with P300 event-related potential for normal young females.
P300 has been demonstrated abnormal for a variety of neuropsychiatric disorders, and heritability has been proposed. We analyzed the event-related potentials for three DRD2 genotype groups in 134 normal young females. The results demonstrate that there is no association for DRD2 genotype and P300 components. Our negative findings in normal subjects suggest association demonstrated for P300 latency and the DRD2 allele may be disease dependent.
Lin
C H
CH
Kai-Suan Psychiatric Hospital, Kaohsiung, Taiwan, ROC.
Yu
Y W
YW
Chen
T J
TJ
Tsa
S J
SJ
Hong
C J
CJ
D000328:Adult; D017931:DNA Primers; D018913:Event-Related Potentials, P300 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012016:Reference Values; D012727:Sex Characteristics; D019914:Taq Polymerase
D017931:DNA Primers; D017448:Receptors, Dopamine D2; D019914:Taq Polymerase