title: [Acute lymphoblastic leukemia complicated with tumor lysis syndrome--four cases report].
abstract: OBJECTIVE
  To report four acute lymphoblastic leukemia(ALL) patients who developed tumor lysis syndrome(TLS) after initial chemotherapy.
  
  
  METHODS
  The clinical features and blood biochemical changes of four patients with TLS were analysed.
  
  
  RESULTS
  TLS was characterized by hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. Three cases had renal dysfunction and the other died of acute renal failure. After allopurinol therapy and alkalinization of urine, the blood biochemical parameter became normalization in all the three cases.
  
  
  CONCLUSIONS
  TLS can be effectively controlled by early recognition and administration of allopurinol therapy and alkalinization of urine.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.
authors.forename: H
authors.initials: H
authors.lastname: He
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Han
mesh_terms: D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage; D000963:Antimetabolites / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003630:Daunorubicin / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011241:Prednisone / Q000009:adverse effects; D015275:Tumor Lysis Syndrome / Q000188:drug therapy / Q000209:etiology*; D014750:Vincristine / Q000009:adverse effects
chemical_list: D000963:Antimetabolites; D014750:Vincristine; D000493:Allopurinol; D011241:Prednisone; D003630:Daunorubicin