title: Intracranial aneurysms in Ehlers-Danlos syndrome type IV in early childhood.
abstract: Ehlers-Danlos syndrome type IV is of special interest to neurologists because of the risk of cerebrovascular complications. We describe a 5-year-old female with Ehlers-Danlos syndrome type IV, demonstrating multiple intracranial aneurysms and right middle cerebral artery stenosis. The diagnosis of Ehlers-Danlos syndrome type IV was confirmed by electron microscopic examination of a skin biopsy. To our knowledge, this is the youngest reported patient with intracranial aneurysms associated with the Ehlers-Danlos syndrome type IV. Ehlers-Danlos syndrome type IV should be considered in the differential diagnosis of cerebrovascular disorder and stroke in early childhood.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Hattori
authors.forename: T
authors.initials: T
authors.lastname: Yorifuji
authors.forename: Y
authors.initials: Y
authors.lastname: Tashiro
authors.forename: T
authors.initials: T
authors.lastname: Nakahata
mesh_terms: D017668:Age of Onset; D001706:Biopsy; D002561:Cerebrovascular Disorders / Q000175:diagnosis; D002675:Child, Preschool; D003251:Constriction, Pathologic; D003937:Diagnosis, Differential; D004535:Ehlers-Danlos Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000209:etiology* / Q000473:pathology; D018810:Magnetic Resonance Angiography; D020768:Middle Cerebral Artery / Q000473:pathology*; D012867:Skin / Q000473:pathology*