title: [International Study of Asthma and Allergies in Childhood (ISAAC) Phase II: Methodology and results of the participation rate in Spain].
abstract: BACKGROUND
  The ISAAC phase I results have supplied valuable information on the prevalence of asthma and allergy in childhood throughout the world.
  
  
  OBJECTIVE
  To describe the implementation and participation rate of normal children in each test performed in phase II of the ISAAC in the four Spanish cities participating the study, and to establish the influence of type of school and geographical situation (in a polluted or unpolluted area) in Cartagena.
  
  
  METHODS
  The ISAAC phase II included a questionnaire on symptoms, risk factors and treatment, skin examination, skin-prick test, bronchial challenge test, total and specific IgE measurement, as well as mite and bacterial endotoxin determination in house dust. The questionnaire was distributed with a letter requesting authorization from the parents in primary schools (fourth and fifth grades) in sufficient number to achieve approximately 1,000 skin prick-test authorizations in each city.
  
  
  RESULTS
  The participation rate for the questionnaire, skin examination, skin-prick test, blood extraction, bronchial challenge test, and dust collection was, respectively, for each city: Cartagena: 58.9, 49.2, 43.2, 33.1, 39.9 and 29.8 %; Almería: 42.5, 40.6, 39.1, 39.1 and 37.6 %; Valencia: 43.7, 30.4, 23.5, 21.5, 20.1 and 17.1 %; Madrid: 53.2, 40.8, 38.6, 27.6, 30.6 and 21.1 %. In Cartagena, participation was significantly higher in private schools receiving a state subsidy and in those in unpolluted areas.
  
  
  CONCLUSIONS
  The participation rate was highly variable and lower than that among the European centres that have already completed the study. The rate was significantly influenced by geographical area and type of school.
authors.affiliation: Unidad de Investigación y U.D. de Pediatría, Universidad de Murcia, Cartagena, Spain. lgmarcos@um.es
authors.forename: L
authors.initials: L
authors.lastname: García-Marcos Alvarez
authors.forename: A
authors.initials: A
authors.lastname: Martínez Torres
authors.forename: J
authors.initials: J
authors.lastname: Batlles Garrido
authors.forename: M
authors.initials: M
authors.lastname: Morales Suárez-Varela
authors.forename: G
authors.initials: G
authors.lastname: García Hernández
authors.forename: A
authors.initials: A
authors.lastname: Escribano Montaner
mesh_terms: D001249:Asthma / Q000453:epidemiology*; D002648:Child; D006306:Health Surveys; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D013030:Spain / Q000453:epidemiology