Progressive arterial thrombosis in a patient with non-Hodgkin's lymphoma, a lupus anticoagulant, factor V Leiden mutation and paraprotein, following chemotherapy.
We report a case of non-Hodgkin's lymphoma (NHL), with a preceding history of sarcoidosis, in a patient with a lupus anticoagulant (LA), a low-level paraprotein and heterozygosity for the factor V Leiden mutation. Following cytotoxic chemotherapy the patient developed a progressive arterial thrombosis necessitating a left below-knee amputation.
Shaw
B E
BE
Department of Haematology, Royal Free Hospital, Pond Street, Hampstead, London, NW3 2QG.
Perry
D
D
Hoffbrand
A V
AV
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001157:Arterial Occlusive Diseases / Q000209:etiology*; D005165:Factor V / Q000235:genetics; D006801:Humans; D007083:Iliac Artery; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010266:Paraproteins / Q000378:metabolism; D013927:Thrombosis / Q000209:etiology*
D016682:Lupus Coagulation Inhibitor; D010266:Paraproteins; C095381:factor V Leiden; D005165:Factor V