Ciprofloxacin-loaded bovine serum albumin microspheres: preparation and drug-release in vitro.
Ciprofloxacin albumin microspheres were prepared by the spray drying technique, with bovine serum albumin as the natural biodegradable wall material. The spherical microspheres, flowed well, were organic solvent free and in the size range 1-5 microm. The drug release from the microspheres could be retarded by further thermal denaturation. The sustained-release microspheres were suitable for dry powder inhaled lung drug delivery systems.
Li
F Q
FQ
Department of Pharmaceutical Sciences, Changhai Hospital, Second Military Medical University, Shanghai, China. fqli@citiz.net
Hu
J H
JH
Lu
B
B
Yao
H
H
Zhang
W G
WG
D000818:Animals; D002214:Capsules; D002417:Cattle; D002939:Ciprofloxacin / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011489:Protein Denaturation; D012710:Serum Albumin, Bovine
D002214:Capsules; D003692:Delayed-Action Preparations; D012710:Serum Albumin, Bovine; D002939:Ciprofloxacin