Ischemic heart disease associated with vincristine and doxorubicin chemotherapy.
OBJECTIVE
To report the ocurrence of ischemic heart disease (IHD) in a patient with multiple myeloma treated with vincristine and doxorubicin.


METHODS
A 46-year-old man developed a Q-wave inferior and right-ventricle myocardial infarction with postinfarction angina after receiving his third cycle of vincristine and doxorubicin for immunoglobulin A multiple myeloma. Angiography showed two small filling defects consistent with thrombi in the distal right coronary artery.


CONCLUSIONS
IHD may be a serious but uncommon complication of treatment with several chemotherapeutic agents. It is likely that chemotherapy played a role in the development of IHD in our patient. Several putative mechanisms for vascular toxicity have been associated with chemotherapy.


CONCLUSIONS
Chemotherapy with vincristine and doxorubicin may play a role in the ocurrence of IHD. Physicians should possess an awareness of this potentially serious complication of chemotherapy.
Calvo-Romero
J M
JM
Department of Internal Medicine, Clideba Clinic, Badajoz, Spain.
Fernández-Soria-Pantoja
R
R
Arrebola-Garcia
J D
JD
Gil-Cubero
M
M
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use; D004452:Echocardiography; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy; D009203:Myocardial Infarction / Q000188:drug therapy; D017202:Myocardial Ischemia / Q000139:chemically induced*; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D007070:Immunoglobulin A; D014750:Vincristine; D004317:Doxorubicin