Stevens-Johnson Syndrome and cholestatic hepatitis.
Stevens-Johnson Syndrome (SJS) is a rare but severe dermatological condition that typically occurs after the ingestion of medications such as nonsteroidal drugs, antibiotics, and anticonvulsants. Extracutaneous manifestations of the syndrome can occur and may involve the conjunctiva, trachea, buccal mucosa, gastrointestinal tract, and genitourinary tract. Cholestatic liver disease, which may precede the skin manifestations of SJS, has been reported to occur in SJS, but the medical literature has only 10 case reports describing this phenomenon (1-9). We report the case of a 19-year-old female with SJS and cholestatic liver disease. A discussion of the underlying pathophysiology of SJS and its treatment follows.
Morelli
M S
MS
Department of Internal Medicine, Section of General Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
O'Brien
F X
FX
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002779:Cholestasis / Q000209:etiology*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen