title: Phylogenetic analysis of the hepatitis B virus (HBV) genotype F including Argentine isolates.
abstract: Seven human hepatitis B virus (HBV) genotypes have been described. Genotype F, indigenous to the Americas, is the most diverging group. Our in-depth analysis of the genetic distances of this genotype included ten Argentine samples. Phylogenetic analysis on the small (S) gene of the surface antigen showed four different clusters within genotype F, which were associated with a well-defined geographical origin. Even closely connected sequences sharing a common ancestor had shown some characteristics or markers indicating geographical differentiation. Nucleotide sequences and amino acids translated according to the polymerase open reading frame (P-ORF), rather than S-ORF, yielded a more discriminating analysis.
authors.affiliation: Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina. vmbayed@ffyb.uba.ar
authors.forename: V A
authors.initials: VA
authors.lastname: Mbayed
authors.forename: L
authors.initials: L
authors.lastname: Barbini
authors.forename: J L
authors.initials: JL
authors.lastname: López
authors.forename: R H
authors.initials: RH
authors.lastname: Campos
mesh_terms: D001118:Argentina / Q000453:epidemiology; D005838:Genotype; D006509:Hepatitis B / Q000453:epidemiology / Q000821:virology*; D006515:Hepatitis B virus / Q000145:classification* / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014759:Viral Envelope Proteins / Q000235:genetics
chemical_list: C118669:S envelope protein, hepatitis B virus; D014759:Viral Envelope Proteins