title: Synthesis of antitumor dendritic imides.
abstract: Dendritic imides were synthesized and evaluated as antitumor compounds. Compounds 8 and 11 showing a promising profile as inhibitors of lck but their antiproliferative activity against HT-29 was not so relevant.
authors.affiliation: Department of Organic and Pharmaceutical Chemistry, University San Pablo-CEU, Boadilla del Monte 28668, Madrid, Spain. mfbrana@ceu.es
authors.forename: M F
authors.initials: MF
authors.lastname: Braña
authors.forename: G
authors.initials: G
authors.lastname: Domínguez
authors.forename: B
authors.initials: B
authors.lastname: Sáez
authors.forename: C
authors.initials: C
authors.lastname: Romerdahl
authors.forename: S
authors.initials: S
authors.lastname: Robinson
authors.forename: T
authors.initials: T
authors.lastname: Barlozzari
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002277:Carcinoma / Q000188:drug therapy; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007094:Imides / Q000737:chemistry* / Q000494:pharmacology*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D007094:Imides; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)