title: Chemokines and central nervous system disorders.
abstract: Chemokines and their receptors are large families of inflammatory molecules responsible for a number of biologic functions including the accumulation of leukocytes at tissue sites. Over the past 8 years, a number of studies have indicated a role for chemokines in the pathogenesis of CNS inflammatory diseases. This minireview provides a brief summary of our current knowledge of chemokines and CNS inflammatory diseases including experimental autoimmune encephalomyelitis, multiple sclerosis, virus-induced demyelinating diseases, Alzheimer's disease, and central nervous system bacterial-induced diseases.
authors.affiliation: Department of Pathology, Northwestern University Medical School, 303 E. Chicago Avenue, W127, Chicago, IL 60611, USA. w-karpus@northwestern.edu
authors.forename: W J
authors.initials: WJ
authors.lastname: Karpus
mesh_terms: D002493:Central Nervous System Diseases / Q000276:immunology* / Q000821:virology*; D018925:Chemokines / Q000276:immunology*; D018792:Encephalitis, Viral / Q000276:immunology*; D006801:Humans
chemical_list: D018925:Chemokines