title: [Antineoplastic activity of 5-fluorouracil upon transdermal adminstration using "Coletex" napkins].
abstract: The paper presents data on the effect of 5-fluorouracil (5-FU)-impregnated Coletex napkins on rats and mice with transplantable subcutaneous tumors of different histological patterns: Pliss lymphosarcoma, Walker carcinosarcoma and Ehrlich carcinoma. Since the napkins showed antitumor activity it is suggested that they might find application in treating a number of oncological pathologies, particularly, skin lesions and ulcerated and necrotized tumors.
authors.affiliation: Central Research Institute of Roentgeno-Radiology, Ministry of Health of the RF, St. Petersburg.
authors.forename: L P
authors.initials: LP
authors.lastname: Vartanian
authors.forename: N D
authors.initials: ND
authors.lastname: Oltarzhevskaia
authors.forename: S F
authors.initials: SF
authors.lastname: Vershinina
authors.forename: G F
authors.initials: GF
authors.lastname: Gornaeva
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Pustovalov
authors.forename: M A
authors.initials: MA
authors.lastname: Korovina
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D051381:Rats
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil