[Mechanism of bone lengthening by the Ilizarov technique].
Distraction osteogenesis relies on two local factors: 1 degree mechanical stretching multiplicates the fibroblastic population; 2 degrees hypoxia, by vessel elongation and cellular compaction, induces osteogenic stress protein metabolism. Progressive return to aerobic conditions assumes permanency of the new osseous structures. The precise technical procedure of Ilizarov brings under control the osteogenic process with unprecedented human clinical results.
Danis
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Laboratoire de Chirurgie expérimentale de la Faculté de Médecine, Université libre de Bruxelles.
D000332:Aerobiosis / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena; D004195:Disease Models, Animal; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*; D005347:Fibroblasts / Q000502:physiology; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000378:metabolism; D018889:Ilizarov Technique; D010012:Osteogenesis / Q000502:physiology*; D011859:Radiography; D051381:Rats; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*; D016896:Treatment Outcome
D006360:Heat-Shock Proteins