Methamphetamine toxicity in mice is potentiated by exposure to loud music.
Methamphetamine (METH) is a drug of abuse used for its stimulant effects. Its neurotoxicity is very variable, and is increased by a number of factors, including crowded conditions and increased ambient temperature. The effects of such factors are increasingly important, with the widespread use of these stimulants at nightclubs and 'raves'. Here, we compared the effect of another dominant feature of nightclubs, continuous loud noise, on the toxicity of METH in mice. We found that mice exposed to loud music exhibited longer lasting stereotypy, an altered place preference in the open field and had more seizures than mice given METH in a quiet setting or when exposed to loud white noise. A greater increase in reactive gliosis was also seen after exposure to METH and loud music. Thus, METH appears to be more toxic when taken while exposed to loud music.
Morton
A J
AJ
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK.
Hickey
M A
MA
Dean
L C
LC
D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005911:Gliosis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D007150:Immunohistochemistry; D008694:Methamphetamine / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009146:Music / Q000523:psychology*; D017072:Neostriatum / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009498:Neurotoxins / Q000633:toxicity; D009622:Noise / Q000009:adverse effects*; D012640:Seizures / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology
D000697:Central Nervous System Stimulants; D005904:Glial Fibrillary Acidic Protein; D009498:Neurotoxins; D008694:Methamphetamine