title: Treatment modalities for oral verrucous carcinomas and their outcomes: contribution of radiotherapy and chemotherapy.
abstract: BACKGROUND
  This clinical study focused, firstly, on the results of treatment and, secondly, on the anaplastic transformation, of oral verrucous carcinomas (OVCs) diagnosed and treated from 1981 to 1997 at the Department of Oral and Maxillofacial Surgery at Shimane Medical University Hospital.
  
  
  METHODS
  We analyzed the treatment modalities and outcomes for 15 patients with OVC.
  
  
  RESULTS
  Excluding the results for 4 palliatively treated patients, the disease-free survival rates of the patients after the initial treatments, were 82% at 5 years and 66% at 10 years; for all 15 patients, these rates were 57% and 46%, respectively. Surgery alone and surgery combined with other treatments (such as radiotherapy and chemotherapy) appeared to yield disease-free survival rates to those achieved superior with other treatments whether single or combined; (78% vs 33% for 5-year disease-free survival; 52% vs 33% for 10-year disease-free survival); however, the difference was not significant (P = 0.47). Well differentiated squamous cell carcinomas (W-SCCs) (n = 5) as well as spindle cell carcinoma (n = 1) were found in subsequent operative or biopsy specimens.
  
  
  CONCLUSIONS
  Surgery was the most reliable treatment method for OVC; however, radiotherapy combined with chemotherapy was the next most preferable treatment when surgery was not undertaken. We also found that highly malignant transformation (anaplastic transformation) occasionally occurred during treatments for OVC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Shimane Medical University, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan. omfs1@shimane-med.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshimura
authors.forename: K
authors.initials: K
authors.lastname: Mishima
authors.forename: S
authors.initials: S
authors.lastname: Obara
authors.forename: Y
authors.initials: Y
authors.lastname: Nariai
authors.forename: H
authors.initials: H
authors.lastname: Yoshimura
authors.forename: T
authors.initials: T
authors.lastname: Mikami
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018289:Carcinoma, Verrucous / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D002471:Cell Transformation, Neoplastic; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D010166:Palliative Care; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016896:Treatment Outcome