title: Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas.
abstract: This study examined p53 expression immunocytochemically in 40 lingual squamous cell carcinomas from Dutch patients with known histories of smoking and/or drinking alcohol. 30% of neoplasms showed positive p53 reactivity, suggesting increased levels of p53 protein. No alcohol or tobacco risk factors were evident in 33.3% (4/12) of p53-positive neoplasms whereas only 7.1% (2/28) of p53-negative neoplasms showed an absence of these risk factors. 25% (3/12) of p53-positive neoplasms and 71.4% (20/28) of p53-negative neoplasms were found in patients who had been exposed to both alcohol and tobacco. A similar negative association with p53 reactivity was also found when either tobacco or alcohol were used in isolation. The results contrast with previous observations in head/neck and oral carcinomas and indicate that the association of alcohol/tobacco and p53 expression remains open to question.
authors.affiliation: Unit of Oral Pathology, School of Dentistry, St Chad's Queensway, Birmingham, B4 6NN, U.K.
authors.forename: J B
authors.initials: JB
authors.lastname: Matthews
authors.forename: C
authors.initials: C
authors.lastname: Scully
authors.forename: A
authors.initials: A
authors.lastname: Jovanovic
authors.forename: I
authors.initials: I
authors.lastname: Van der Waal
authors.forename: W A
authors.initials: WA
authors.lastname: Yeudall
authors.forename: S S
authors.initials: SS
authors.lastname: Prime
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012907:Smoking / Q000009:adverse effects*; D014062:Tongue Neoplasms / Q000209:etiology* / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D016159:Tumor Suppressor Protein p53