[Regulation of elastin synthesis].
Elastin is the main protein of elastic fibers and confers the property of elastic recoil to the tissues such as arteries, lung, elastic cartilage,... Elastin synthesis goes through several steps: gene transcription, alternative splicing of pre-mRNA, mRNA translation, hydroxylation of some proline residues of the newly synthesized protein-tropoelastin-, association of with a 67 kDa chaperone protein, secretion of tropoelastin molecules in the extracellular space, and their deposition on the microfibrillar scaffold which contains fibrillin 1, fibrillin 2, MAGP 1 and MAGP 2,.... After the synthesis of cross-links-lysinonorleucine, desmosine, isodesmosine-, elastin becomes insoluble and elastic. The elastogenic pathway is regulated at many levels. The most recently described regulatory mechanism of elastin synthesis is the control of elastin mRNA stability. Elastogenesis is well controlled during development and aging but remains responsive to external factors such as soluble compounds-cytokines, vitamins, hormones,...- and hemodynamic stress. In order to ensure its function, both quantity and quality of elastin should be and should remain optimal in elastic tissues.
Jacob
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INSERM U460, UFR de Médecine Xavier Bichat, 16, rue Henri Huchard, 75870 Paris. jacob@bichat.inserm.fr
Sauvage
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Osborne-Pellegrin
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D017398:Alternative Splicing; D020087:Alu Elements; D000818:Animals; D002417:Cattle; D003285:Contractile Proteins / Q000378:metabolism; D004547:Elastic Tissue / Q000378:metabolism; D004548:Elasticity; D004549:Elastin / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins; D000071838:Fibrillin-1; D000071840:Fibrillin-2; D000071837:Fibrillins; D005786:Gene Expression Regulation; D005796:Genes; D006133:Growth Substances / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D018832:Molecular Chaperones / Q000502:physiology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011487:Protein Conformation; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D012322:RNA Precursors / Q000235:genetics; D000072260:RNA Splicing Factors; D012333:RNA, Messenger / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D012995:Solubility; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic; D014333:Tropoelastin / Q000378:metabolism; D054392:Adipokines
D003285:Contractile Proteins; D004549:Elastin; D016326:Extracellular Matrix Proteins; D000071838:Fibrillin-1; D000071840:Fibrillin-2; D000071837:Fibrillins; D006133:Growth Substances; D008840:Microfilament Proteins; D018832:Molecular Chaperones; D012322:RNA Precursors; D000072260:RNA Splicing Factors; D012333:RNA, Messenger; D014333:Tropoelastin; C000605722:FBN1 protein, human; D054392:Adipokines; C000605723:FBN2 protein, human; C016598:microfibrillar protein