title: Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick.
abstract: It is known that central injection of glucagon-like peptide-1 (GLP-1) suppresses feeding in rats and chicks, but the systems for GLP-1 are still open with special reference to the chick. The present study was done to determine whether a noradrenergic mechanism contributes to the anorexigenic effect of GLP-1 on the neonatal chick. Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. However, in spite of that dopamine (DA) did not affect food intake, coadministration of inhibitor of dopamine-beta-hydroxylase (DBH), fusaric acid (FA), attenuated the suppressive effect of GLP-1 on feeding behavior. It is suggested that there may be the interactive relationships between GLP-1 and noradrenergic system in the neonatal chick.
authors.affiliation: Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan. bungo@agr.ehime-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Bungo
authors.forename: S I
authors.initials: SI
authors.lastname: Kawakami
authors.forename: A
authors.initials: A
authors.lastname: Ohgushi
authors.forename: K
authors.initials: K
authors.lastname: Sashihara
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Sugahara
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
authors.forename: D M
authors.initials: DM
authors.lastname: Denbow
authors.forename: M
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000855:Anorexia / Q000139:chemically induced*; D002645:Chickens; D015259:Dopamine Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005669:Fusaric Acid / Q000494:pharmacology*; D005934:Glucagon / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*
chemical_list: D015259:Dopamine Agents; D010446:Peptide Fragments; D011498:Protein Precursors; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D005669:Fusaric Acid; D009638:Norepinephrine