title: Urinary excretion of vasoactive factors are correlated to sodium excretion.
abstract: BACKGROUND
  The relationship between urinary vasoactive factors and sodium excretion has not been adequately addressed in humans.
  
  
  METHODS
  Excretion rates of sodium, nitrates/nitrites (NOx), cGMP, and endothelin-1 (ET-1) were measured before and after ingestion of a mixed electrolyte solution (8 oz Gatorade) while undergoing a routine cardiovascular evaluation in a sample of 51 normotensive young adults.
  
  
  RESULTS
  Significant correlations were detected for changes in excretion between all four variables, r ranged from 0.50 to 0.86 (P < .001). Correlations were higher in African Americans than white Americans.
  
  
  CONCLUSIONS
  The association of renal ET-1 and NO activity with sodium excretion supports the hypothesis that these factors play a role in the physiologic response to acute changes in sodium intake, particularly in African Americans.
authors.affiliation: Georgia Prevention Institute, Vascular Biology Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912-2500, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Jackson
authors.forename: F A
authors.initials: FA
authors.lastname: Treiber
authors.forename: G A
authors.initials: GA
authors.lastname: Harshfield
authors.forename: J L
authors.initials: JL
authors.lastname: Waller
authors.forename: J S
authors.initials: JS
authors.lastname: Pollock
authors.forename: D M
authors.initials: DM
authors.lastname: Pollock
mesh_terms: D000293:Adolescent; D000328:Adult; D044383:Black People; D006152:Cyclic GMP / Q000502:physiology / Q000652:urine*; D019332:Endothelin-1 / Q000502:physiology / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008297:Male; D009318:Natriuresis; D009569:Nitric Oxide / Q000502:physiology / Q000652:urine*; D012964:Sodium / Q000652:urine*; D014481:United States; D044465:White People; D001741:Black or African American
chemical_list: D019332:Endothelin-1; D009569:Nitric Oxide; D012964:Sodium; D006152:Cyclic GMP