title: Antihuman Immunodeficiency Virus (HIV-1) Activities of Inhibitors of Polyamine Pathways.
abstract: Four inhibitors of polyamine biosynthetic pathways were tested for their effect on HIV-1 replication in phytohemagglutinin-stimulated human peripheral blood mononuclear cells. Methyl acetylenic putrescine (MAP) and alpha-monofluoromethyldehydroornithine methyl ester, irreversible inhibitors of ornithine decarboxylase, inhibited the production of p24 antigen in phytohemagglutinin-stimulated peripheral blood mononuclear cells by clinical HIV-1 strains isolated from HIV-infected patients with IC(50) values of about 1-2 &mgr;M. 5'--5'-deoxyadenosine (MDL 73811), an enzyme-activated irreversible inhibitor of S-adenosyl-L-methionine (AdoMet) decarboxylase, also inhibited the production of p24 antigen by HIV-1 strains in peripheral blood mononuclear cells with IC(50) values of 1-2 &mgr;M. The least potent was 1-aminoxyethylamine which is another inhibitor of AdoMet decarboxylase. MAP showed the best therapeutic index of 500-1,000. Copyright 1996 S. Karger AG, Basel
authors.affiliation: Division of Retrovirology, Walter Reed Army Institute of Research, Washington, D.C., USA.
authors.forename: P.K.
authors.initials: PK
authors.lastname: Chiang
authors.forename: P.P.
authors.initials: PP
authors.lastname: McCann
authors.forename: J.R.
authors.initials: JR
authors.lastname: Lane
authors.forename: M.C.
authors.initials: MC
authors.lastname: Pankaskie
authors.forename: D.S.
authors.initials: DS
authors.lastname: Burke
authors.forename: D.L.
authors.initials: DL
authors.lastname: Mayers