title: Levels of cord blood thyroid stimulating hormone after external cephalic version.
abstract: OBJECTIVE
  To investigate the relationship between breech presentation, external cephalic version and levels of cord blood thyroid stimulating hormone.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  The study group consisted of 289 consecutive singleton deliveries at term over a four-year period, all of whom had an attempt at external cephalic version performed near term for breech presentation. The control group included 23,001 singleton term deliveries during the same four-year period.
  
  
  METHODS
  Between group differences were compared with the Mann-Whitney U test or chi2 test when appropriate.
  
  
  METHODS
  Levels of cord blood thyroid stimulating hormone and the incidence of false positive screening results for congenital hypothyroidism.
  
  
  RESULTS
  Babies who were born vaginally after prior successful external cephalic version had significantly higher median levels of cord blood thyroid stimulating hormone (6.4 vs 6.0 mlU/L, P = 0.034) and the incidence of false positive screening for thyroid stimulating hormone (12.9% vs 7.2%, P = 0.016, OR 1.9) compared with babies with spontaneous cephalic presentation. In babies with a breech presentation born by elective caesarean section, previous attempts at external cephalic version had no effect on cord blood thyroid stimulating hormone levels. There was also no difference in the levels of cord blood thyroid stimulating hormone between cephalic and breech-presenting fetuses born by elective caesarean section. However, breech-presenting babies born by emergency caesarean section after onset of labour had higher median levels of cord thyroid stimulating hormone than those with cephalic presentation (5.1 vs 4.5 mIU/L, P= 0.008).
  
  
  CONCLUSIONS
  Levels of cord blood thyroid stimulating hormone are elevated in babies born vaginally after a successful external cephalic version. This finding may represent a biological difference in fetal response to the stress of labour in breech-presenting fetuses, which is not correctable by a successful external cephalic version.
authors.affiliation: Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin.
authors.lastname: Cha LYS
authors.forename: T K
authors.initials: TK
authors.lastname: Lau
authors.forename: P Y
authors.initials: PY
authors.lastname: Chiu
authors.forename: G
authors.initials: G
authors.lastname: Wing-KinWong
authors.forename: T N
authors.initials: TN
authors.lastname: Leung
mesh_terms: D000328:Adult; D001946:Breech Presentation; D016022:Case-Control Studies; D003409:Congenital Hypothyroidism; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005315:Fetal Diseases / Q000097:blood / Q000209:etiology; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000175:diagnosis; D007744:Obstetric Labor Complications / Q000097:blood; D011247:Pregnancy; D012189:Retrospective Studies; D013312:Stress, Physiological / Q000097:blood / Q000209:etiology; D013972:Thyrotropin / Q000097:blood*; D014710:Version, Fetal / Q000009:adverse effects*
chemical_list: D013972:Thyrotropin