title: New phenanthridine linkers for the solid-phase synthesis of acid-containing compounds.
abstract: Two novel, reusable phenanthridine linkers that use cerium ammonium nitrate as a cleavage reagent are described. These linkers are based on a disubstituted amide and are designed for the release of carboxylic acids but tolerate exposure to acidic, basic, and reductive reaction conditions. Application of these linkers to solid-phase organic synthesis affords products in excellent yields and high purities.
authors.affiliation: Department of Chemistry, National Central University, Chung-Li, Taiwan 32054, ROC. ch01@ncu.edu.tw
authors.forename: W R
authors.initials: WR
authors.lastname: Li
authors.forename: Y S
authors.initials: YS
authors.lastname: Lin
authors.forename: N M
authors.initials: NM
authors.lastname: Hsu