title: Role of viral isolate in the etiopathogenetic determinism of HCV infection: diagnostic and epidemiological evaluation.
abstract: HCV genotyping by nucleic acid sequencing emphasizes the difficulties involved in carrying out a more precise determination of the infectant viral population, probably due in part to the finding of still unknown isolates. Signs of heterogeneity in the genotype composition of the viral quasi-species and its evolutionary dynamism over time, together with the role played by some, more potentially aggressive, isolates in causing hepatic damage, encourage a more in-depth study of such topics.
authors.affiliation: ASL 3 Genovese Clinical Pathology Department, Genoa University.
authors.forename: G
authors.initials: G
authors.lastname: Ravera
authors.forename: M
authors.initials: M
authors.lastname: Franceschini
authors.forename: S
authors.initials: S
authors.lastname: Zanardi
authors.forename: L C
authors.initials: LC
authors.lastname: Bottaro
authors.forename: T
authors.initials: T
authors.lastname: Colombi
authors.forename: G F
authors.initials: GF
authors.lastname: Percario
authors.forename: M
authors.initials: M
authors.lastname: Carbone
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004279:DNA, Viral / Q000032:analysis; D018740:Genetic Heterogeneity; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase