DNA priming and recombinant pox virus boosters for an AIDS vaccine.
Eight different protocols for immunization have been compared for the ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain.
Robinson
H L
HL
Yerkes Regional Primate Research Center, Atlanta, GA 30329, USA.
Montefiori
D C
DC
Johnson
R P
RP
Kalish
M L
ML
Lydy
S L
SL
McClure
H M
HM
D016915:AIDS Vaccines / Q000008:administration & dosage* / Q000235:genetics; D000818:Animals; D005587:Fowlpox virus / Q000235:genetics / Q000276:immunology*; D015483:HIV Antibodies / Q000096:biosynthesis; D007111:Immunity, Cellular; D007117:Immunization, Secondary; D008253:Macaca mulatta; D009500:Neutralization Tests; D018449:SAIDS Vaccines / Q000008:administration & dosage / Q000235:genetics; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000235:genetics
D016915:AIDS Vaccines; D015483:HIV Antibodies; D018449:SAIDS Vaccines; D019444:Vaccines, DNA