Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation.
There is no reliable laboratory indicator of the onset of chronic graft-versus-host disease (cGVHD). This study looks at whether the expression of OX40, a member of the tumor necrosis factor receptor family, is related to the development of cGVHD in patients who underwent allogeneic hematopoietic stem cell transplantation. Peripheral blood mononuclear cells from 22 patients after day 100 were subjected to multicolor flow cytometry. The percentages of both OX40+CD4+ and OX40+CD8+ T cells were significantly higher in patients with cGVHD than those without (P <.0001 and P =.001, respectively). Serial analyses showed that OX40+CD4+ T cells elevated before the onset of cGVHD and closely correlated with the therapeutic response. The expression of CD25, CD69, and HLA-DR was partially detectable on OX40+ T cells. These results indicate that serial measurement of OX40+ T cells is useful for predicting the onset as well as the therapeutic response of cGVHD and raise a possibility that the OX40/gp34 system is involved in the pathogenesis of cGVHD.
Kotani
A
A
Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ishikawa
T
T
Matsumura
Y
Y
Ichinohe
T
T
Ohno
H
H
Hori
T
T
Uchiyama
T
T
D000741:Anemia, Aplastic / Q000628:therapy; D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015415:Biomarkers; D002908:Chronic Disease; D005434:Flow Cytometry; D006086:Graft vs Host Disease / Q000097:blood* / Q000209:etiology / Q000401:mortality / Q000628:therapy; D006684:HLA-DR Antigens / Q000032:analysis; D019337:Hematologic Neoplasms / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D037181:Lectins, C-Type; D015375:Receptors, Interleukin-2 / Q000032:analysis; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; D012720:Severity of Illness Index; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D014184:Transplantation, Homologous / Q000009:adverse effects*; D016896:Treatment Outcome; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000032:analysis* / Q000502:physiology; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D006684:HLA-DR Antigens; D037181:Lectins, C-Type; D015375:Receptors, Interleukin-2; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D000099192:CD69 Antigens; C505716:TNFRSF4 protein, human