title: Accelerated treatment for early and late postpneumonectomy empyema.
abstract: BACKGROUND
  Postpneumonectomy empyema is a rare but serious complication of pneumonectomy. Despite use of various therapeutic approaches and techniques during the last five decades, successful therapy remains difficult and is often associated with high morbidity and prolonged hospitalization.
  
  
  METHODS
  We evaluated a concept for accelerated treatment, which consists of radical debridement of the pleural cavity and packing with wet dressings of povidoneiodine. This was repeated in the operating theater every second day, until the chest cavity was macroscopically clean. If present, bronchial stump insufficiency was closed and secured by omentopexy. Finally, the pleural space was obliterated with antibiotic solution.
  
  
  RESULTS
  Twenty patients, 13 with early postpneumonectomy empyema (10 to 89 days; mean, 37 days) and 7 with late postpneumonectomy empyema (124 to 7,200 days; mean, 1,126 days) were treated. Fifteen patients presented with bronchopleural fistula (11 right, 4 left), which developed after chemotherapy (n = 6) or after radiotherapy (n = 3) (unknown cause in 4 patients). Six patients were referred after previously unsuccessful surgical attempts. Pleural cultures were positive in 17 cases for one or several bacteria including fungoides (n = 2). The average number of interventions was 3.5 (3 to 5). The chest was definitively closed in all patients within 8 days. Mean hospitalization time was 17 days (7 to 35 days). During the same hospitalization, 2 patients needed reoperation because of an undetected bronchopleural fistula. Postpneumonectomy empyema was successfully treated in all patients. There was no in-hospital or 3-month postoperative mortality.
  
  
  CONCLUSIONS
  Repeated surgical debridement combined with closure of bronchopleural fistula and antimicrobial therapy enables successful treatment of early and late postpneumonectomy empyema within a short period and is a well-tolerated concept.
authors.affiliation: Department of Surgery, University Hospital, Zurich, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Schneiter
authors.forename: P
authors.initials: P
authors.lastname: Cassina
authors.forename: S
authors.initials: S
authors.lastname: Korom
authors.forename: I
authors.initials: I
authors.lastname: Inci
authors.forename: M
authors.initials: M
authors.lastname: Al-Abdullatief
authors.forename: A
authors.initials: A
authors.lastname: Dutly
authors.forename: P
authors.initials: P
authors.lastname: Kestenholz
authors.forename: W
authors.initials: W
authors.lastname: Weder
mesh_terms: D000328:Adult; D000368:Aged; D016724:Empyema, Pleural / Q000209:etiology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000009:adverse effects*; D013997:Time Factors