New steroidal alkaloids from an undescribed sponge of the genus Corticium.
Two new steroidal alkaloids, along with a previously reported one of the plakinamine class, were isolated from the sponge Corticium sp. collected from Guam. The structures of the new compounds were determined by combined spectroscopic methods. These compounds exhibited moderate cytotoxicity and antifungal activity as well as DNA- and RNA-cleaving activities.
Lee
H S
HS
Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, Ansan P.O. Box 29, Seoul, 425-600, Korea.
Seo
Y
Y
Rho
J R
JR
Shin
J
J
Paul
V J
VJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000187:drug effects; D004269:DNA, Bacterial / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004586:Electrophoresis; D004926:Escherichia coli / Q000235:genetics; D006141:Guam; D006801:Humans; D007938:Leukemia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D012336:RNA, Ribosomal, 16S / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S; D013256:Steroids; C442619:plakinamine E; C442620:plakinamine F; C090333:lokysterolamine A; D004247:DNA