"T-cell-rich B-cell lymphoproliferative disorder" of the bone marrow.
We report four cases of a "T-cell-rich B-cell chronic lymphoproliferative disorder" involving the bone marrow and not extramedullary sites. The neoplastic B-cell proliferation in these cases was composed predominantly of small lymphoid cells with features of both hairy cell leukemia and lymphoplasmacytoid lymphoma. All cases presented with neutropenia and with difficulty in diagnosis. We present the clinical, morphologic, cytochemical, and immunophenotypic findings in these cases and discuss this entity.
Aboul-Nasr
R
R
Division of Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston 77030-4095, USA.
O'Brien
S
S
Freireich
E J
EJ
Ginsberg
C F
CF
Kantarjian
H M
HM
Koller
C A
CA
Keating
M J
MJ
Albitar
M
M
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000175:diagnosis / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D013601:T-Lymphocytes / Q000166:cytology