title: Newer methods of labeling diagnostic agents with Tc-99m.
abstract: The past several years have seen marked advances in technetium/rhenium chemistry applicable to the preparation of new 99mTc-labeled radiopharmaceuticals. This article focuses on recent developments in technetium chemistry, including the preparation of "3 + 1" complexes, the preparation and use of (99mTc[CO]3)+ complexes for labeling biomolecules, the preparation of rhenium steroid inclusion complexes, improvements in both hydrazinonicotinamide labeling chemistry and in the preformed 99mTc complex method of labeling biomolecules, and new solid-phase separation techniques that may allow the isolation of high specific-activity radiopharmaceuticals in a clinical setting.
authors.affiliation: Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore 21201, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Mease
authors.forename: C
authors.initials: C
authors.lastname: Lambert
mesh_terms: D007553:Isotope Labeling / Q000379:methods; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D017556:Technetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D019275:Radiopharmaceuticals; D017556:Technetium Compounds