title: Upregulated expression of N-syndecan, a transmembrane heparan sulfate proteoglycan, in differentiated neural stem cells.
abstract: Adult rat hippocampus-derived neural stem cells are incorporated into neural tissues, and differentiate to neuronal and glial cells. However, the cell surface protein molecules are, to date, undefined. RT-PCR, immunoblotting and immunocytochemistry showed the increased expression of N-syndecan, a transmembrane heparan sulfate proteoglycan, in the neural stem cells after the differentiation induced by retinoic acid. Our data indicate that N-syndecan may be involved in the differentiation of neural stem cells.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Inatani
authors.forename: M
authors.initials: M
authors.lastname: Haruta
authors.forename: M
authors.initials: M
authors.lastname: Honjo
authors.forename: A
authors.initials: A
authors.lastname: Oohira
authors.forename: N
authors.initials: N
authors.lastname: Kido
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Honda
authors.forename: H
authors.initials: H
authors.lastname: Tanihara
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D015151:Immunoblotting; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D011509:Proteoglycans / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013234:Stem Cells / Q000378:metabolism*; D053670:Syndecan-3; D014212:Tretinoin / Q000378:metabolism; D015854:Up-Regulation / Q000502:physiology*
chemical_list: D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D011509:Proteoglycans; D012333:RNA, Messenger; C508303:Sdc3 protein, rat; D053670:Syndecan-3; D014212:Tretinoin