title: The sleep switch: hypothalamic control of sleep and wakefulness.
abstract: More than 70 years ago, von Economo predicted a wake-promoting area in the posterior hypothalamus and a sleep-promoting region in the preoptic area. Recent studies have dramatically confirmed these predictions. The ventrolateral preoptic nucleus contains GABAergic and galaninergic neurons that are active during sleep and are necessary for normal sleep. The posterior lateral hypothalamus contains orexin/hypocretin neurons that are crucial for maintaining normal wakefulness. A model is proposed in which wake- and sleep-promoting neurons inhibit each other, which results in stable wakefulness and sleep. Disruption of wake- or sleep-promoting pathways results in behavioral state instability.
authors.affiliation: Dept of Neurology, Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. csaper@caregroup.harvard.edu
authors.forename: C B
authors.initials: CB
authors.lastname: Saper
authors.forename: T C
authors.initials: TC
authors.lastname: Chou
authors.forename: T E
authors.initials: TE
authors.lastname: Scammell
mesh_terms: D000818:Animals; D006801:Humans; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D009434:Neural Pathways; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*