Comparative analysis of age-related changes in activities of monoamine oxidase-B and antioxidant defense enzymes in various structures of human brain.
Activities of monoamine oxidase B, Cu-Zn-dependent superoxide dismutase (SOD), and catalase, and concentration of enzyme-active ceruloplasmin were measured in brain preparations from 43 humans died at the age of 21-92 years. Activity of monoamine oxidase B in the neocortex, cerebellum, basal ganglia, and stem structures increased with age, while SOD activity decreased and catalase and ceruloplasmin concentrations slightly increased. A contribution of age-related increase of cerebral monoamine oxidase activity into ontogenetic impairment of the antioxidant defense in human brain is discussed.
Volchegorskii
I A
IA
Department of General and Bioorganic Chemistry, Chelyabinsk State Medical Academy.
Shemyakov
S E
SE
Turygin
V V
VV
Malinovskaya
N V
NV
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D001479:Basal Ganglia / Q000201:enzymology; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D002374:Catalase / Q000378:metabolism; D002531:Cerebellum / Q000201:enzymology; D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism*; D019579:Neocortex / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D008995:Monoamine Oxidase