title: Skew deviation and inferior oblique palsy.
abstract: OBJECTIVE
  To describe ocular motility and neuro-ophthalmologic findings in six patients with an ocular tilt reaction (OTR) that mimicked an inferior oblique palsy (IOP).
  
  
  METHODS
  Observational Case Series.
  
  
  METHODS
  Series of six patients presenting to tertiary care pediatric or neuro-ophthalmologist.
  
  
  RESULTS
  Five patients had ocular motility and three-step test results suggesting an IOP; one patient had a suspected bilateral IOP. All six patients had excyclotorsion of the hypotropic eye, and four had incyclotorsion of the hypertropic eye. This is contrary to that expected with an IOP (incyclotorsion of the hypotropic eye). In addition, all six patients had other neurologic findings in the history or examination that were associated with neurologic insult rather than an isolated IOP. Two patients had surgery consisting of a superior rectus recession; this was successful in eliminating diplopia in both patients and in eliminating the vertical deviation and head posturing in one patient.
  
  
  CONCLUSIONS
  While many vertical deviations that appear to be due to an inferior oblique palsy based on the results of the three-step test may be caused by inferior oblique weakness, skew deviation should also be considered in any patient with a history of head trauma, or other neurologic findings. The cyclotorsion observed in IOP is opposite that seen with OTR, and differentiates the two entities clinically. We postulate that these deviations are caused by damage to the otolithic projections that correspond to those from the ipsilateral posterior semicircular canal (on the side of the hypotropic eye).
authors.affiliation: Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-8808, USA. sean.donahue@mcmail.vanderbilt.edu
authors.forename: S P
authors.initials: SP
authors.lastname: Donahue
authors.forename: P J
authors.initials: PJ
authors.lastname: Lavin
authors.forename: B
authors.initials: B
authors.lastname: Mohney
authors.forename: L
authors.initials: L
authors.lastname: Hamed
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D003941:Diagnostic Techniques, Ophthalmological; D005133:Eye Movements; D005260:Female; D019416:Head Movements; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000473:pathology*; D009886:Ophthalmoplegia / Q000175:diagnosis*; D013285:Strabismus / Q000175:diagnosis*; D015348:Vision, Binocular; D014792:Visual Acuity