Human papillomavirus genotypes in rural Mozambique.
We studied the genotype distribution of cervical human papillomavirus (HPV) infections in an age-stratified sample of 262 women in Mozambique using the PGMYO9-PGMY11 primer system in a reverse line-blot strip-based assay with high sensitivity in type-specific amplification. Despite the low precision of the estimates, we found that HPV-16 was not the dominant type. Instead, HPV 35 was the most commonly identified genotype among HPV-positive women (16/96 [17%]) and women with cervical neoplasia (7/23 [30%]). Certain genotypes might have been under-detected in previous studies, and type-specific HPV distributions might vary across populations. Therefore, the estimated proportion of cervical neoplasia that could be prevented by an HPV-16-based vaccine could be lower than expected.
Castellsagué
X
X
Menéndez
C
C
Loscertales
M P
MP
Kornegay
J R
JR
dos Santos
F
F
Gómez-Olivé
F X
FX
Lloveras
B
B
Abarca
N
N
Vaz
N
N
Barreto
A
A
Bosch
F X
FX
Alonso
P
P
D000293:Adolescent; D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009073:Mozambique / Q000453:epidemiology; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000235:genetics; D015995:Prevalence; D012424:Rural Population; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000235:genetics; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000235:genetics / Q000821:virology*