The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders.
The dopamine transporter is a plasma membrane protein that controls the spatial and temporal domains of dopamine neurotransmission through the accumulation of extracellular dopamine. The dopamine transporter may play a role in numerous dopamine-linked neuropsychiatric disorders. We review the cloning and organization of the human dopamine transporter gene, polymorphisms in its coding and noncoding sequence, and emerging data on its transcriptional regulation.
Bannon
M J
MJ
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Rm 2309 Scott Hall, 540 E. Canfield Ave., 48201, Detroit, MI, USA. mbannon@med.wayne.edu
Michelhaugh
S K
SK
Wang
J
J
Sacchetti
P
P
D000818:Animals; D001483:Base Sequence; D004298:Dopamine / Q000235:genetics / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D023061:Gene Order / Q000235:genetics*; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D001523:Mental Disorders / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D014158:Transcription, Genetic / Q000235:genetics*
D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D004298:Dopamine