Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
Phagocytosis is a phylogenetically ancient process by which eukaryotic cells engulf insoluble substances whose size exceeds approximately 0.5 microm. The engulfment process requires the concerted action of several fundamental cellular pathways and is governed by multiple transmembrane signaling events. Here we focus on phagocytosis mediated by a well-studied class of phagocytic receptors that recognize the Fc portion of IgG (Fc(gamma)Rs ).
Cox
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Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA. dc209@columbia.edu
Greenberg
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D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors / Q000502:physiology; D000199:Actins / Q000378:metabolism; D000818:Animals; D003599:Cytoskeleton / Q000502:physiology; D004792:Enzyme Precursors / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes / Q000378:metabolism; D010587:Phagocytosis / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases; D051966:Phospholipase C gamma; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D017452:Receptors, IgG / Q000502:physiology*; D015398:Signal Transduction; D000072377:Syk Kinase; D010738:Type C Phospholipases / Q000378:metabolism; D019061:src-Family Kinases / Q000502:physiology
D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors; D000199:Actins; D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes; D019869:Phosphatidylinositol 3-Kinases; D051966:Phospholipase C gamma; D011505:Protein-Tyrosine Kinases; D017452:Receptors, IgG; D000072377:Syk Kinase; D010738:Type C Phospholipases; D019061:src-Family Kinases; C000606896:SYK protein, human