title: Cytokine production inhibitors produced by a fungus, Oidiodendron griseum.
abstract: A series of diterpenes were isolated from the fermentation broth of a fungus, Oidiodendron griseum CL37215. The diterpenes were identified as LL-Z1271alpha, LL-Z1271gamma, CJ-14,445, PR 1388, CJ-14,604 and a new diterpene, CJ-14,515. They inhibited both lipopolysaccharide-induced interleukin-1beta and tumor necrosis factor-alpha production in human whole blood with IC50s of the range from 0.049 to 100 microM.
authors.affiliation: Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc., Chita-gun, Aichi, Japan. katsuomi.ichikawa@japan.pfizer.com
authors.forename: K
authors.initials: K
authors.lastname: Ichikawa
authors.forename: H
authors.initials: H
authors.lastname: Hirai
authors.forename: M
authors.initials: M
authors.lastname: Ishiguro
authors.forename: T
authors.initials: T
authors.lastname: Kambara
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: Y
authors.initials: Y
authors.lastname: Matsunaga
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: Y
authors.initials: Y
authors.lastname: Shiomi
authors.forename: N
authors.initials: N
authors.lastname: Yoshikawa
authors.forename: L H
authors.initials: LH
authors.lastname: Huang
authors.forename: N
authors.initials: N
authors.lastname: Kojima
mesh_terms: D001203:Ascomycota / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000097:blood; D007930:Leucine / Q000378:metabolism; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D004224:Diterpenes; D007375:Interleukin-1; D011753:Pyrones; D013729:Terpenes; D014409:Tumor Necrosis Factor-alpha; C013363:LL-Z 1271alpha; D007930:Leucine