[A preliminary result of treatment of progressive multiple sclerosis with autologous peripheral blood stem cell transplantation in China].
OBJECTIVE
To explore the clinical effect for treatment of progressive multiple sclerosis (PMS) by autologous peripheral blood stem cell transplantation (Auto-PBSCT).


METHODS
One PMS patient was chosen. Peripheral blood stem cells (PBSCs) were mobilized with cyclophosphamide and G-CSF. The CD34+ cells harvesting was performed by continuous flow leukapheresis using a CS3000 plus blood separator. About 12.2 x 10(6) CD34+ cells/kg was collected and preserved at -196 degrees C in liquid nitrogen. PBSCs were reinfused after conditioned by CTX (120 mg/kg) and TBI(10 GY). G-CSF was used to help hematopoietic and immunologic reconstitution.


RESULTS
After transplantation the patient received clinical remission, and the abnormal signals of MRI in T1-T4 disappeared, the examination results of the neuro-electrophysiology and T cell subgroup were improved obviously. There was no relapse after 6 months follow up.


CONCLUSIONS
Auto-PBSCT is effective and safety for PMS. Duration of remission remains to be decided in long-term follow up.
Ouyang
J
J
Department of Hematology, Affiliated Drum Tower Hospital of School Medicine, Nanjing University, Nanjing 210008, China.
Ni
X
X
Chen
B
B
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D020528:Multiple Sclerosis, Chronic Progressive / Q000628:therapy*; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide