Inverse correlation between macrophage-colony stimulating factor, cholesterol and high density lipoprotein cholesterol in Kawasaki disease.
Kawasaki disease (KD) is a childhood-onset vascular disease. We assessed the concentrations of macrophage-colony stimulating factor (M-CSF) and those of lipids in sera from patients with KD. The M-CSF concentration in patients with acute-phase KD was 2,914+/-159 U/ml, significantly higher than that in control subjects with Infectious diseases (1,241+/-96 U/ml). The elevated levels of this cytokine in the acute phase fell to 1,319+/-138 U/ml in the convalescent phase. Total and high-density lipoprotein cholesterol concentrations in acute phase KD (113.8+/-8.4 and 21.5+/-2.3 mg/dl, respectively) were lower than in the infectious disease controls (195.8+/-7.0 and 62.5+/-1.8 mg/dl). The elevation of M-CSF correlated with the decrease of total and high-density lipoprotein cholesterol. Overproduction of macrophage-colony stimulating factor activates macrophages and monocytes and may disturb the lipid metabolism. Both effects could contribute to vasculitis in KD.
Shikishima
Y
Y
Department of Pediatrics, Kitasato University School of Medicine, Kanagawa, Japan.
Kawano
Y
Y
Shirai
H
H
Matsuura
N
N
Noma
T
T
D002669:Child Welfare; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood* / Q000187:drug effects; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D007229:Infant Welfare; D007564:Japan / Q000453:epidemiology; D007958:Leukocyte Count; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood* / Q000187:drug effects; D008297:Male; D009000:Monocytes / Q000166:cytology / Q000378:metabolism; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000188:drug therapy; D013223:Statistics as Topic
D008076:Cholesterol, HDL; D016756:Immunoglobulins, Intravenous; D016173:Macrophage Colony-Stimulating Factor; D002784:Cholesterol