N-heterocyclic derivatives of 2,4-dihydroxybenzcarbothioamide as antimycotic agents.
N-heterocyclic derivatives of 2,4-dihydroxybenzcarbothioamide were synthesized from sulfinylbis(2,4-dihydroxybenzenethioyl) and commercially available heterocyclic amines. The composition and chemical structures were confirmed by IR, (1)H NMR, EI-MS, and elemental analysis. For the estimation of potential activity in vitro the MIC values against 15 strains of dermatophytes, yeasts, and molds were determined. The strongest fungistatic potency was found for N-5'-(3'-oxobenzfurylidyne)-2,4-dihydroxybenzcarbothioamide in relation to all tested dermatophyte strains with MIC = 0.48-0.98 microg/mL. On the basis of the spectroscopic data the influence of N-heterocyclic substitution on antimycotic activity is discussed.
Matysiak
J
J
Department of Chemistry, University of Agriculture, Akademicka 15, 20-950 Lublin, Poland. jmaty@agros.ar.lublin.pl
Krajewska-Kułak
E
E
Karczewski
J
J
Niewiadomy
A
A
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000145:classification / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013045:Species Specificity; D013854:Thioamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
C443342:2,4-dihydroxybenzcarbothioamide; D000935:Antifungal Agents; D013854:Thioamides