title: Evidence for stretch-induced resistance increase of proximal coronary microcirculation.
abstract: We investigated the influence of stretch on regional hemodynamic parameters of the septal circulation. We used a similar experimental setup and mathematical model, as described previously (14). Five ventricular septa were isolated from anesthetized dogs, sutured to a biaxial stretching apparatus, and perfused with an oxygenated perfluorochemical emulsion at maximal vasodilation. Under unloaded and biaxially stretched conditions, flow and septal thickness (to index vascular volume) were measured continuously. Pressure was varied sinusoidally at 30, 50, and 70 mmHg with amplitude of 7.5 mmHg over frequencies ranging between 0.015 and 7 Hz. Admittance (flow/pressure) and capacitance (thickness/pressure) transfer functions were calculated and interpreted in terms of a two-compartmental model with volume-dependent resistances. Parameter estimation showed that the proximal resistance and compliance were unaffected, whereas the resistance of the proximal part of the microcirculation, including the small arterioles, increased with stretch. The effect of stretch on the distal resistance and capacitance, however, could not be determined unequivocally.
authors.affiliation: Man Machine Systems and Control Group, Faculty of Design, Engineering and Production, Department of Biomedical Engineering and Mechanics, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cornelissen
authors.forename: J A
authors.initials: JA
authors.lastname: Spaan
authors.forename: J
authors.initials: J
authors.lastname: Dankelman
authors.forename: C C
authors.initials: CC
authors.lastname: Chan
authors.forename: F C
authors.initials: FC
authors.lastname: Yin
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000502:physiology*; D004285:Dogs; D006346:Heart Septum / Q000502:physiology; D008833:Microcirculation / Q000502:physiology; D008955:Models, Cardiovascular; D013314:Stress, Mechanical; D014655:Vascular Resistance / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology