Multiple granulocytic sarcomas in acute myeloblastic leukemia with simultaneous occurrence of t(8:21) and trisomy 8.
This report describes a rare case of multiple intracranial, extradural chloromas. A five year old African American male presented with headache, fever, and vomiting. The peripheral blood smear showed myeloblasts with Auer rods. The CTscan of the brain showed three intracranial, epidural lesions as well as soft tissue masses in the retroorbital region and sphenoid sinuses. CTscan of the chest showed two paraspinal epidural thoracic masses. Pathology of the epidural intracranial mass revealed a granulocytic sarcoma. Cytogenetic analysis showed simultaneous occurrence of t(8;21) and trisomy 8. Following induction therapy, he is now in complete remission.
Somjee
S
S
Department of Pediatric Hematology-Oncology, LSU Health Sciences Center & Childrens Hospital, New Orleans, LA 70118, USA.
Borker
A
A
Gardner
R
R
Velez
M C
MC
D001932:Brain Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D020732:Cytogenetic Analysis; D015174:Epidural Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D011859:Radiography; D012074:Remission Induction; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics; D014178:Translocation, Genetic; D014314:Trisomy