Keratitis caused by Candida glabrata in a patient with chronic granulomatous disease.
OBJECTIVE
To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease.


METHODS
Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids.


RESULTS
Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B.


CONCLUSIONS
Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection.
Djalilian
A R
AR
National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1863, USA. djalilia@inta.nei.nih.gov
Smith
J A
JA
Walsh
T J
TJ
Malech
H L
HL
Robinson
M R
MR
D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003315:Cornea / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006105:Granulomatous Disease, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008100:Liver Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D014792:Visual Acuity
D000935:Antifungal Agents; D000666:Amphotericin B