title: Is there a role for gastric accommodation and satiety in asymptomatic obese people?
abstract: OBJECTIVE
  The relationships of gastric accommodation and satiety in moderately obese individuals are unclear. We hypothesized that obese people had increased gastric accommodation and reduced postprandial satiety. The objective of this study was to compare gastric accommodation and satiety between obese and non-obese asymptomatic subjects.
  
  
  METHODS
  In 13 obese (body mass index [BMI] > or = 30 kg/m(2); mean BMI, 37.0 +/- 4.9 kg/m(2)) and 19 non-obese control subjects (BMI < 30 kg/m(2); mean BMI, 26.2 +/- 2.9 kg/m(2)), we used single photon emission computed tomography to measure fasting and postprandial gastric volumes and expressed the accommodation response as the ratio of postprandial/fasting volumes. The satiety test measured maximum tolerable volume of ingestion of liquid nutrient meal (Ensure) and symptoms 30 minutes after cessation of ingestion.
  
  
  RESULTS
  Total fasting and postprandial gastric volumes and the ratio of postprandial/fasting gastric volume were not different between asymptomatic obese and control subjects. However, the fasting volume of the distal stomach was greater in obese than in control subjects. Maximum tolerable volume of ingested Ensure and aggregate symptom score 30 minutes later were also not different between obese and control subjects.
  
  
  CONCLUSIONS
  Asymptomatic obese individuals (within the BMI range of 32.6 to 48 kg/m(2)) did not show either increased postprandial gastric accommodation or reduced satiety. These data suggest that gastric accommodation is unlikely to provide an important contribution to development of moderate obesity.
authors.affiliation: Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: D Y
authors.initials: DY
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Camilleri
authors.forename: J A
authors.initials: JA
authors.lastname: Murray
authors.forename: D A
authors.initials: DA
authors.lastname: Stephens
authors.forename: J A
authors.initials: JA
authors.lastname: Levine
authors.forename: D D
authors.initials: DD
authors.lastname: Burton
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D012527:Satiation; D012727:Sex Characteristics; D013270:Stomach / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon