[Pro and contra regarding the threshold/non-threshold mutagenic (carcinogenic) action of low-level ionizing radiation].
According to the analysis of epidemiological and experimental data there are evidences in threshold on criterion of mutagenic (in broad sense) ionising radiation action. A threshold takes place in the region of about 20-200 mGy concerning a dose in case of an acute exposure and in the region of the third order above a background level regarding a dose rate in case of chronic or prolonged exposure. Evidences in favour of linear non-threshold conception are based on primitive mathematical extrapolations and approximations of the study results, mainly, in the region of intermediate doses/dose rates. Besides real data in region of low doses are ignored. The latter has a reason in paradigm of stochastic damage action of ionising radiation and in underestimation of cell and organism protection-reparation systems action. Regarding axiomatic bases of ionising radiation action it is possible to conclude more reliable substantiation of the dual (positive-negative) nature and the threshold conception concerning ionising radiation action in comparison with the non-threshold one.
Rozhdestvenskiĭ
L M
LM
State Research Centre of Russia-Institute of Biophysics, Moscow, 123182 Russia. rozhd@mail.ru
D000818:Animals; D002478:Cells, Cultured; D004249:DNA Damage; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000528:radiation effects; D005720:Gamma Rays; D000882:Haplorhini; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D016296:Mutagenesis; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011829:Radiation Dosage; D011830:Radiation Effects; D011831:Radiation Genetics; D011839:Radiation, Ionizing; D051381:Rats; D013997:Time Factors