title: Furodysin lactone and pyrodysinoic acid, new sesquiterpenes from a Philippines Dysidea species.
abstract: Chemical investigation of a Dysidea sponge, collected at Siquijor, Philippines, has afforded two new sesquiterpenoid metabolites, which we have termed furodysin lactone (1) and pyrodysinoic acid (2). The known 3,6,11-trihydroxy-9,11-secoergostane-7,24(28)-dien-9-one (3) was also encountered. Structure elucidation of the isolated metabolites involved high-field 2-D NMR spectroscopy including (1)H-(1)H COSY, HSQC, and HMBC.
authors.affiliation: Pharmacia Corporation, 700 Chesterfield Parkway North, Chesterfield, Missouri 63198, USA. gilles.h.goetz@pharmacia.com
authors.forename: G H
authors.initials: GH
authors.lastname: Goetz
authors.forename: G G
authors.initials: GG
authors.lastname: Harrigan
authors.forename: J
authors.initials: J
authors.lastname: Likos
mesh_terms: D000818:Animals; D002783:Cholestenones / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D011161:Porifera / Q000737:chemistry*; D012632:Secosteroids / Q000737:chemistry / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D002783:Cholestenones; D012632:Secosteroids; D012717:Sesquiterpenes; C442626:furodysin lactone; C442627:pyrodysinoic acid; C077274:9,11-seco-3,6,11-trihydroxy-24-methylenecholest-7-en-9-one