title: Papillary lesions of the breast: evaluation with stereotactic directional vacuum-assisted biopsy.
abstract: OBJECTIVE
  To evaluate the use of stereotactic directional vacuum-assisted biopsy (SDVAB) in diagnosing and managing papillary lesions of the breast.
  
  
  METHODS
  The authors retrospectively reviewed the mammographic and histopathologic findings of 26 cases in which papillary lesions were diagnosed at SDVAB. In all cases, subsequent surgical excision (n = 20) or long-term imaging follow-up (n = 6) was performed and correlated with findings at SDVAB.
  
  
  RESULTS
  SDVAB of 26 lesions yielded tissue that was classified as benign in 12, atypical in six, and malignant in eight. Of the 12 lesions that were diagnosed as histologically benign at SDVAB, six were surgically excised. Of these six lesions, five yielded benign correlative results. The sixth lesion was thought to be discordant with the imaging findings, and was surgically excised and determined to be malignant. Of the six benign lesions that were not surgically sampled for biopsy, five decreased in size and one was not seen at radiographic follow-up. Of the six lesions diagnosed as atypical at SDVAB that were surgically excised, one was benign and five were atypical. None proved to be malignant. Of the eight lesions diagnosed as malignant at SDVAB, surgical excision demonstrated ductal carcinoma in situ in all eight; two also had foci of invasive carcinoma.
  
  
  CONCLUSIONS
  Benign and malignant papillary lesions of the breast can be reliably diagnosed at SDVAB when the SDVAB results correlate with the imaging findings. However, the extent of malignant papillary disease may be underestimated at SDVAB; in our study, invasive carcinoma was later discovered in 25% of patients with this diagnosis.
authors.affiliation: Department of Radiology, New York Presbyterian Hospital, 161 Fort Washington Ave, 10th Fl, New York, NY 10032, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Mercado
authors.forename: D
authors.initials: D
authors.lastname: Hamele-Bena
authors.forename: C
authors.initials: C
authors.lastname: Singer
authors.forename: T
authors.initials: T
authors.lastname: Koenigsberg
authors.forename: E
authors.initials: E
authors.lastname: Pile-Spellman
authors.forename: H
authors.initials: H
authors.lastname: Higgins
authors.forename: S J
authors.initials: SJ
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D010212:Papilloma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013238:Stereotaxic Techniques