title: Anovulatory infertility: a report of four cases and literature review.
abstract: Four cases of anovulatory/dysovulatory infertility encountered in Ilorin, Nigeria are presented and the literature extensively reviewed on the up-to-date management of this aspect of infertility. All the patients had bilateral tubal patency on hysterosalpingography (HSG) and their husbands had normal seminal fluid analysis. The first case, 30 years of age, had hyperprolactinaemia with galactorrhoea, treated with bromocriptine given 2.5 mg twice daily. Another case, aged 27 years, had polycystic ovarian syndrome with hyperprolactinaemia but no galactorrhea This was treated with clomiphene citrate 100 mg daily. The third case, 34 years old, had hypothyroidism with hyperprolactinaemia and galactorrhea and was treated with thyroxine. The last case, aged 32 years, had hyperprolactinaemia and was treated with bromocriptine and clomiphene citrate. None of the patients had demonstrable pituitary adenoma. After the appropriate treatment, ovulatory menses were restored in all the patients; two have been pregnant, while the other two have not yet achieved pregnancy but have having regular ovulatory menses. All the patients are Nigerians.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Ilorin Teaching Hospital, Ilorin.
authors.forename: M
authors.initials: M
authors.lastname: Anate
authors.forename: A W
authors.initials: AW
authors.lastname: Olatinwo
mesh_terms: D000328:Adult; D000858:Anovulation / Q000453:epidemiology / Q000209:etiology*; D001971:Bromocriptine / Q000627:therapeutic use; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007247:Infertility, Female / Q000453:epidemiology / Q000209:etiology*; D009549:Nigeria / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011247:Pregnancy; D011256:Pregnancy Outcome; D011388:Prolactin / Q000037:antagonists & inhibitors; D012307:Risk Factors; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene; D001971:Bromocriptine; D011388:Prolactin; D013974:Thyroxine