title: Natural course of sensitization in children: follow-up study from birth to 6 years of age, I. Evaluation of total serum IgE and specific IgE antibodies with regard to atopic family history.
abstract: The aim of the study was to evaluate the total serum IgE level and specific IgE antibody responses to alimentary and environmental allergens in the birth cohort of Polish children followed-up from birth to 6 years of age with regard to atopic family history. To study enrolled 52 children. Every child underwent physical examination and in vitro allergy testing at birth, in 6, 12 months of life and in 6 years of age. The mean total serum IgE level was higher in children with atopic family history compared to the children without genetic propensity in every time point, but difference was statistically significant only in six years of age. The highest incidence of positive RAST tests to food allergens was observed in one year of age, mainly in children with atopic family history (36.5%) compared to those without such a history (23.6%). By the age of six years, sensitization to food allergens was observed less frequent in both of the study groups (17.2% and 15%, respectively), whereas the sensitization rates to inhalant allergens were about 53% in tested children with atopic family history compared to 19% in children without such a history.
authors.affiliation: Department of Pediatric Infectious Diseases, Medical Academy of Białystok.
authors.forename: E
authors.initials: E
authors.lastname: Ołdak
authors.forename: B
authors.initials: B
authors.lastname: Kurzatkowska
authors.forename: A
authors.initials: A
authors.lastname: Stasiak-Barmuta
mesh_terms: D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E