Molecular diagnostic tests in the diagnosis and management of thyroid carcinoma.
The application of molecular analysis of gene expression to clinical tissue samples represents one of the most exciting new areas in "translational" thyroid cancer research. Current data suggest that molecular diagnostic assays may improve the sensitivity and accuracy of fine needle aspiration of thyroid nodules, fine needle aspiration of metastases, and detection of recurrent disease in peripheral blood samples. It is likely that at least some of these tests will become useful adjuncts in the diagnostic armamentarium of clinical endocrinologists in the future.
Ringel
M D
MD
Section of Endocrinology, Washington Hospital Center, 110 Irving Street, NW Room 2A46B, Washington, DC 20010, USA. mxr9@mhg.edu
D014408:Biomarkers, Tumor / Q000235:genetics*; D006801:Humans; D008198:Lymph Nodes / Q000737:chemistry; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D019098:Telomerase / Q000235:genetics; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000628:therapy*
D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D019098:Telomerase