Paraneoplastic optic neuropathy and cerebellar ataxia with small cell carcinoma of the lung.
Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the lung. Serologic tests revealed a neuronal autoantibody specific for CRMP-5, a 62-kd member of the collapsin response-mediating protein family. Unexplained optic neuropathy in the setting of subacute cerebellar ataxia should cause suspicion of a paraneoplastic disorder and prompt testing for this autoantibody, especially in patients at risk for lung carcinoma.
Thambisetty
M R
MR
Departments of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Scherzer
C R
CR
Yu
Z
Z
Lennon
V A
VA
Newman
N J
NJ
D000368:Aged; D000912:Antibodies, Neoplasm / Q000097:blood; D000951:Antigens, Neoplasm / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D018288:Carcinoma, Small Cell / Q000150:complications / Q000473:pathology*; D002524:Cerebellar Ataxia / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000276:immunology; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D009419:Nerve Tissue Proteins