Stores to die for.
Genes that regulate apoptosis are well defined. In contrast, it has not been clear what genes are central to necrotic cell loss. In the September 27th issue of Neuron, Xu et al. (2001) report a critical role for genes that regulate storage and release of Ca2+ from the endoplasmic reticulum as important to necrotic-like cellular degeneration in Caenorhabditis elegans.
Bonini
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NM
Department of Biology, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia 19104-6018, USA.
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins; D002118:Calcium / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D007473:Ion Channels / Q000502:physiology*; D008565:Membrane Proteins
D029742:Caenorhabditis elegans Proteins; D007473:Ion Channels; C115871:Mec-4 protein, C elegans; D008565:Membrane Proteins; D002118:Calcium