title: Dedicated breast CT: radiation dose and image quality evaluation.
abstract: OBJECTIVE
  To evaluate the feasibility of breast computed tomography (CT) in terms of radiation dose and image quality.
  
  
  METHODS
  Validated Monte Carlo simulation techniques were used to estimate the average glandular dose (AGD). The calculated photon fluence at the detector for high-quality abdominal CT (120 kVp, 300 mAs, 5-mm section thickness) was the benchmark for assessing the milliampere seconds and corresponding radiation dose necessary for breast CT. Image noise was measured by using a 10-cm-diameter cylinder imaged with a clinical CT scanner at 10-300 mAs for 80, 100, and 120 kVp. A cadaveric breast was imaged in the coronal plane to approximate the acquisition geometry of a proposed breast CT scanner.
  
  
  RESULTS
  The AGD for 80-kVp breast CT was comparable to that for two-view mammography of 5-cm breasts (compressed breast thickness). For thicker breasts, the breast CT dose was about one-third less than that for two-view mammography. The maximum dose at mammography assessed in 1-mm(3) voxels was far higher (20.0 mGy) than that at breast CT (5.4 mGy) for a typical 5-cm 50% glandular breast. CT images of an 8-cm cadaveric breast (AGD, 6.3 mGy) were subjectively superior to digital mammograms (AGD, 10.1 mGy) of the same specimen.
  
  
  CONCLUSIONS
  The potential of high signal-to-noise ratio images with low anatomic noise, which are obtainable at dose levels comparable to those for mammography, suggests that dedicated breast CT should be studied further for its potential in breast cancer screening and diagnosis.
authors.affiliation: Department of Radiology, X-ray Imaging Laboratory, University of California, Davis Medical Center, 4701 X St, Sacramento, CA 95817, USA. jmboone@ucdavis.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Boone
authors.forename: T R
authors.initials: TR
authors.lastname: Nelson
authors.forename: K K
authors.initials: KK
authors.lastname: Lindfors
authors.forename: J A
authors.initials: JA
authors.lastname: Seibert
mesh_terms: D001940:Breast / Q000528:radiation effects; D003198:Computer Simulation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008327:Mammography; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D015898:Tomography Scanners, X-Ray Computed; D014057:Tomography, X-Ray Computed