Hippocampal 1H-MRSI in ecstasy users.
In recent years the illicit drug ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) has come into widespread use among young people. Despite clear evidence for the neurotoxic potential of MDMA in animals, corresponding evidence in humans is limited to indirect findings. In an exploratory study we compared the hippocampal 1H-MRSI (magnetic resonance spectroscopic imaging) spectra of five MDMA users with those of controls with no history of substance abuse. Although 1H
Obergriesser
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NMR-Research, Central Institute of Mental Health P.O. Box l22120 68072 Mannheim, Germany. Tom@skullslicer.zi-mannheim.de
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D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D016022:Case-Control Studies; D002794:Choline; D003401:Creatine / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000009:adverse effects*; D018490:Serotonin Agents / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000175:diagnosis*
D018490:Serotonin Agents; D001224:Aspartic Acid; C000179:N-acetylaspartate; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D003401:Creatine; D002794:Choline