title: Teratogenicity testing of BI 58 EC (38% dimethoate) in chicken embryos with special respect to degradation of the active ingredient.
abstract: The insecticide formulation BI 58 EC was tested for teratogenicity in chicken embryos, with particular reference to degradation of the active ingredient (dimethoate) after the treatment of embryonated eggs. The pesticide was diluted in water to a concentration level of 0.8%, and the emulsion was injected into the air space in a volume of 0.1 ml/egg, or hen's eggs were treated by the immersion technique. Residues of dimethoate were measured in the samples on days, 13, 15 and 19 of the incubation of chicken embryos, and morphological examinations were performed simultaneously. Analytical chemistry data indicated a slower degradation of dimethoate in embryos after the immersion of eggs, and cyllosis was remarkable in this group among the sporadic developmental anomalies. The liver tissues of both treated groups exhibited severe fatty infiltration.
authors.affiliation: Department of Zoology and Toxicology, Institute of Animal Science, Georgikon Faculty of Agriculture, University of Veszprém, H-8361 Keszthely, P.O. Box 71, Hungary. H9650var@ella.hu
authors.forename: L
authors.initials: L
authors.lastname: Várnagy
authors.forename: P
authors.initials: P
authors.lastname: Budai
authors.forename: E
authors.initials: E
authors.lastname: Molnár
authors.forename: I
authors.initials: I
authors.lastname: Füzesi
authors.forename: T
authors.initials: T
authors.lastname: Fáncsi
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000662:veterinary*; D000818:Animals; D002642:Chick Embryo / Q000187:drug effects* / Q000378:metabolism; D004117:Dimethoate / Q000378:metabolism / Q000633:toxicity*; D005234:Fatty Liver / Q000139:chemically induced / Q000662:veterinary*; D007306:Insecticides / Q000378:metabolism / Q000633:toxicity*; D010573:Pesticide Residues / Q000032:analysis / Q000378:metabolism; D013723:Teratogens / Q000378:metabolism / Q000633:toxicity
chemical_list: D007306:Insecticides; D010573:Pesticide Residues; D013723:Teratogens; D004117:Dimethoate