[Expression and significance of vascular permeability factor in nasal polyps].
OBJECTIVE
To study the expression and significance of vascular permeability factor(VPF) in nasal polyps.


METHODS
Expression of VPF and its receptor flk-1 in nasal polyps from 9 patients and inferior turbinates from 8 patients with chronic rhinitis were prospectively studied with immunohistochemistry. Each tissue section was observed under optical microscope.


RESULTS
The VPF positivity in vascular endothelium and in gland cell was significantly higher in nasal polyps than in inferior turbinates (P < 0.01 and P < 0.05, respectively). The flk-1 labeling index of vascular endothelium was significantly higher in nasal polyps than that in inferior turbinates (P < 0.01).


CONCLUSIONS
VPF may play a key role in the formation of heavy edema of nasal polyps.
Yang
J
J
Third Clinical College, Bethune University of Medical Sciences, Changchun 130031.
Kong
H
H
Dong
Z
Z
D000328:Adult; D000368:Aged; D016228:Endothelial Growth Factors / Q000032:analysis*; D004730:Endothelium, Vascular / Q000737:chemistry; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism*; D011446:Prospective Studies; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis; D017978:Receptors, Growth Factor / Q000032:analysis; D040262:Receptors, Vascular Endothelial Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D017978:Receptors, Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor