Humoral hypercalcemia of malignancy in female F344 rats implanted with a transplantable rat pulmonary carcinoma line (IP).
A transplantable rat pulmonary carcinoma line (IP) in F344 rats is a useful animal model for humoral hypercalcemia of malignancy (HHM). The present study analyzed the degree of HHM by implanting IP into F344 female rats aged 6, 20 or 45 weeks. IP-bearing females developed elevated plasma parathyroid hormone-related protein levels, hypercalcemia and increased osteoclastic activity as well as calcification in various organs. The severity of such HHM differed depending on age; particularly, calcification showed age-dependent reduction. HHM development in IP-bearing females may be influenced by age-related factors.
Nakanish
I M
IM
Department of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Japan.
Yamate
J
J
Ide
M
M
Sawamoto
O
O
Kuwamur
M
M
Kotani
T
T
Nakatsuji
S
S
D000367:Age Factors; D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism; D002277:Carcinoma / Q000150:complications / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005269:Femur / Q000473:pathology; D006934:Hypercalcemia / Q000209:etiology / Q000473:pathology*; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D009368:Neoplasm Transplantation; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis; D011506:Proteins / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344; D014407:Tumor Cells, Cultured
D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D002118:Calcium