title: Malignant carcinoid in two brothers.
abstract: Familial occurrence of malignant carcinoid is rare (about 3%). Authors describe occurrence of the malignant carcinoid in two brothers. In the older one the diagnosis was estimated in 1991. He had multiple intestinal carcinoid tumor with multiple liver metastases histological type III by Soga classification. Patient is intermittently treated with somatostatin analogue--lanreotid and with interferon alfa. By this therapy the disease is stabile. In the younger of brothers the diagnosis was estimated in 1999. The disease had rapid progression and in ten months patient died despite of the therapy. Definitive diagnosis was a malignant neuroendocrine tumor of pancreas-mixed low differentiated carcinoid with calcitonin overproduction. (Fig. 4, Ref. 15.)
authors.affiliation: Ist Department of Internal Medicine, University Hospital, Comenius University, Bratislava, Slovakia. kinova@faneba.sk
authors.forename: S
authors.initials: S
authors.lastname: Kinova
authors.forename: I
authors.initials: I
authors.lastname: Duris
authors.forename: E
authors.initials: E
authors.lastname: Kovacova
authors.forename: S
authors.initials: S
authors.lastname: Stvrtina
authors.forename: S
authors.initials: S
authors.lastname: Galbavy
authors.forename: I
authors.initials: I
authors.lastname: Makaiova
mesh_terms: D002276:Carcinoid Tumor / Q000175:diagnosis / Q000235:genetics* / Q000556:secondary; D006801:Humans; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics / Q000556:secondary; D008297:Male; D008303:Malignant Carcinoid Syndrome / Q000235:genetics*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology