[The effect of focal mild hypothermia on the temperature gradient in brain].
OBJECTIVE
Through studying the effect of focal mild hypothermia on the distribution of brain temperature, which reveals the function that the semi-conductor refrigerator apparatus decreases the temperature to mild hypothermia level during therapeutic time window.


METHODS
Directly measure the intracerebral temperatures of different regions when we refrigerator the brains of piglets. According to the results of the measure and the formula of heat conduction, we can establish the three-dimensional space and the temperature gradient mathematical model of pig brain.


RESULTS
(1) The theoretical data deduced by function model fit very well to the laboratory data, absolutely average error is 0.15 degree C. (2) After 17 minutes of the piglet refrigerated at 2-10 degrees C, thalamic and putamen temperature decreases to 32-34 degrees C.


CONCLUSIONS
Apply the regional semi-conductor refrigerator apparatus to decrease the brain temperature to mild hypothermia level during therapeutic time window and find the function relationship between refrigerator temperature and brain temperatures so as to provide the theoretical proof for clinical application of focal mild hypothermia.
Wang
D
D
Department of Neurology, First Medical College, Harbin Medical University, Haerbin 150001, China.
Liu
W
W
Feng
H
H
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology* / Q000628:therapy; D007036:Hypothermia, Induced / Q000295:instrumentation; D066298:In Vitro Techniques; D008297:Male; D008962:Models, Theoretical; D013552:Swine