Hemostasis and thrombosis research in China.
OBJECTIVE
To highlight the development and achievements of hemostasis and thrombosis research in China over the past 50 years.


METHODS
Both Chinese and English language literature search using MEDLINE (1990-1998), and original articles published in the main Chinese and international journals.


METHODS
After reviewing all the main articles on thrombosis and hemostasis, 20 of them were selected that specifically addressed the stated purpose. DATE EXTRATION: The content that could present the progress in hemostasis and thrombosis in China was selected.


RESULTS
Monoclonal antibodies have widely been used in basic research and laboratory diagnosis. Several novel gene mutations of coagulation factors have been identified. Some drugs of traditional Chinese medicine have proved to be efficient in treatment of thrombotic diseases.


CONCLUSIONS
Significant achievements in basic, clinical and pharmacological research in the field of hemostasis and thrombosis have been made in China in the past 50 years. Some new discoveries in platelet membrane glycoproteins and coagulation factors research are believed to be contributions to the international scientific community. However, a specific effort using advanced techniques should be made for future development, especially in molecular biology research.
Ruan
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First Affiliated Hospital of Suzhou Medical College, Jiangsu Institute of Haematology, Suzhou 215007, China.
D001779:Blood Coagulation Factors / Q000235:genetics; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005169:Factor VIII / Q000235:genetics*; D006467:Hemophilia A / Q000175:diagnosis*; D006487:Hemostasis; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis / Q000628:therapy*; D009154:Mutation; D010980:Platelet Membrane Glycoproteins / Q000235:genetics
D001779:Blood Coagulation Factors; D004365:Drugs, Chinese Herbal; D010980:Platelet Membrane Glycoproteins; D005169:Factor VIII