title: Cytokeratin immunophenotyping of an unusual cervical vertebral chordoma with extensive chondroid foci and perilaryngeal recurrence: a case report with review of the literature.
abstract: Chordomas are midline, slowly growing, and locally destructive tumors derived from vestigial remnants of the notochord. We present an unusual case of a cervical vertebral chordoma with extensive chondroid change that aggressively recurred in the anterior larynx and surrounding neck structures, and subsequently in the mediastinum, resulting in the death of the patient. Recent literature has investigated and debated the significance of chondroid elements in chordomas as a differential diagnostic and a prognostic indicator. In particular, the use of immunohistochemical stains for cytokeratin and mesenchymal markers in these areas as a means of distinguishing true from pseudocartilage has received much attention. In this study, we used a spectrum of cytokeratin subtypes (CK 7, 20, 5/6, AE1/3) to further characterize these chondroid areas, and observed that they were positive for the majority of the cytokeratin subtypes, suggesting pseudo, rather than true, cartilaginous change. Clinicopathologic features of this lesion and the recent literature are reviewed.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center-Presbyterian, Pittsburgh, PA 15213, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Horn
authors.forename: J C
authors.initials: JC
authors.lastname: Fowler
authors.forename: R
authors.initials: R
authors.lastname: Carrau
authors.forename: E L
authors.initials: EL
authors.lastname: Barnes
authors.forename: U N
authors.initials: UN
authors.lastname: Rao
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002574:Cervical Vertebrae; D002817:Chordoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D007633:Keratins; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000601:surgery; D010784:Photomicrography; D013125:Spinal Neoplasms / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D007633:Keratins