title: Disconnective hemispherectomy.
abstract: Hemispherectomy is a valuable procedure in the management of seizure disorders caused by unilateral hemispheric disease. Modifications to anatomical hemispherectomy have been proposed to reduce the incidence of superficial cerebral hemosiderosis and hydrocephalus while still achieving seizure control. We report on the modification of a previously described disconnective form of hemispherectomy. We used this procedure on 2 children, with the aid of stereotactic navigation in 1 of the 2 cases. This disconnection was achieved via a transventricular route with minimal cortical resection or disruption of the blood supply. Over the 20 months of follow-up, 1 patient achieved complete seizure control, and 1 patient achieved control of previously incapacitating seizures with few minor seizures persisting. Motor function and speech significantly improved in both patients. Blood loss during the two procedures was significantly less than that reported for anatomical hemispherectomy, and so far there have been no signs of postoperative complications. The hospital stay was limited to 7-14 days after surgery.
authors.affiliation: Department of Pediatric Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, Calif, USA.
authors.forename: M
authors.initials: M
authors.lastname: Danielpour
authors.forename: C S
authors.initials: CS
authors.lastname: von Koch
authors.forename: S G
authors.initials: SG
authors.lastname: Ojemann
authors.forename: W J
authors.initials: WJ
authors.lastname: Peacock
mesh_terms: D002540:Cerebral Cortex / Q000002:abnormalities / Q000503:physiopathology / Q000601:surgery*; D002675:Child, Preschool; D004292:Dominance, Cerebral / Q000502:physiology*; D017036:Epilepsia Partialis Continua / Q000503:physiopathology / Q000601:surgery*; D017029:Epilepsy, Complex Partial / Q000503:physiopathology / Q000601:surgery*; D004830:Epilepsy, Tonic-Clonic / Q000503:physiopathology / Q000601:surgery*; D005500:Follow-Up Studies; D006429:Hemiplegia / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D013238:Stereotaxic Techniques