Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of the nervous system.
Peripheral blood mononuclear cells and plasma of 113 patients with neurological disorders and 150 blood donors were analyzed for HHV-6 and HHV-7 sequences by PCR. The prevalence of HHV-6 was significantly higher in patients with multiple sclerosis (P < 0.01) than in cases of nondemyelinating diseases of the central and demyelinating diseases of the peripheral nervous systems and blood donors. HHV-6 viremia was found only in patients with multiple sclerosis, predominantly in the active phase of the disease. A significantly higher frequency of HHV-7 reactivation in patients with demyelinating diseases of the peripheral nervous system suggests also its association with demyelinating processes.
Tomsone
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V
August Kirchenshtein Institute of Microbiology and Virology, University of Latvia, Ratsupites st. 1, Riga LV-1067, Latvia. vtomsone@hotmail.com
Logina
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I
Millers
A
A
Chapenko
S
S
Kozireva
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S
Murovska
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D016199:Herpesvirus 7, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D019349:Roseolovirus Infections / Q000453:epidemiology*; D014766:Viremia / Q000473:pathology
D004279:DNA, Viral