Structured drug-loaded bioresorbable films for support structures.
Bioresorbable films can serve simultaneously as anatomic support structures and as drug delivery platforms. In the present study, bioresorbable PLLA films containing dexamethasone were developed through solution processing. The effect of processing parameters on the film morphology and the resulting mechanical properties was studied. A model describing the structuring of these films is suggested. Generally, the solvent evaporation rate determines the kinetics of drug and polymer crystallization and thus, both the mode of drug dispersion in the polymer and the resulting mechanical properties. Two types of structured films were studied: (1) a polymer film with drug located on its surface, obtained due to drug skin formation accompanied by a later polymer core formation; and (2) a polymer film with small drug particles and crystals distributed within the bulk, obtained by parallel solidification of the two components. A prototypical application of these films is an expandable biodegradable support structure (stent). which we have developed. This stent demonstrated good initial mechanical properties. The film structure has only a minor effect on the stent radial compression strength, but more significantly affects the tensile mechanical properties.
Zilberman
M
M
Department of Surgery, University of Texas Southwestern Medical Center at Dallas, 75390, USA. meital.zilberman@email.swmed.edu
Schwade
N D
ND
Meidell
R S
RS
Eberhart
R C
RC
D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D003907:Dexamethasone; D016503:Drug Delivery Systems; D019344:Lactic Acid; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011108:Polymers
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D003907:Dexamethasone