Cutaneous leishmaniasis infection in Balb/c mice using a Leishmania tropica strain isolated from Turkey.
Leishmania tropica, which is endemic in Turkey, is the causative agent of cutaneous leishmaniasis. Leishmania tropica promastigotes (2 x 10(7)) isolated from a patient with dermal leishmaniasis and reproduced in NNN medium were inoculated subcutaneously into the footpads of 10 Balb/c mice. Cutaneous leishmaniasis developed on the footpads of 4 mice approximately 45 days later. Leishmania tropica amastigotes were observed in smear slides and then cultivated in NNN medium. Balb/c mice are a suitable laboratory model for this isolate of L. tropica and thus a source of amastigotes for studies on the immunology, chemotherapy, and pathogenicity of cutaneous leishmaniasis.
Girginkardeşler
N
N
Celal Bayar University, School of Medicine, Department of Parasitology, Manisa, Turkey.
Balcioğlu
I C
IC
Yereli
K
K
Ozbilgin
A
A
Ozbel
Y
Y
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007895:Leishmania tropica / Q000254:growth & development*; D016773:Leishmaniasis, Cutaneous / Q000469:parasitology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D014421:Turkey