A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus.
A new dimeric stilbene, namely, artogomezianol (1), and the known compound andalasin A (2) were isolated from the roots of Artocarpus gomezianus. Both 1 and 2 showed moderate tyrosinase inhibitory activity with IC(50) values of 68 and 39 microM, respectively.
Likhitwitayawuid
K
K
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Kittisak.L@chula.ac.th
Sritularak
B
B
D002845:Chromatography; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D029586:Moraceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013785:Thailand
D004791:Enzyme Inhibitors; D013267:Stilbenes; C426659:andalasin A; C442566:artogomezianol; D014442:Monophenol Monooxygenase