Implanted electrochemical glucose sensors for the management of diabetes.
By maintaining a near normal (70-120 mg/dL) glucose concentration, diabetic patients can drastically reduce the likelihood of the occurrence of diabetes complications. In the near future, subcutaneously implanted electrochemical glucose sensors will be available to provide frequent or continuous information on which timely treatment decisions, such as insulin injection or glucose source intake, can be based, as well as timely alarm signals. The currently engineered devices are of three types: (a) innocuous microsensors, with actively mass-transporting areas < 10(-3) cm2, replaced twice a week by the patient; (b) self-contained, surgeon-implanted, transmitter-containing packages of > 1 cm2 area, operating for > 100 days; and (c) devices transporting subcutaneous fluid to an external sensor, based on implanted microfiltration or microdialysis fibers or on iontophoretic transport of the subcutaneous fluid through the skin.
Heller
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Department of Chemical Engineering and Texas Materials Institute, University of Texas at Austin, Austin, Texas 78712-1062, USA. heller@che.utexas.edu
D001672:Biocompatible Materials; D001698:Biomedical Engineering; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D001826:Body Fluids / Q000737:chemistry; D003920:Diabetes Mellitus / Q000097:blood; D004563:Electrochemistry; D006801:Humans; D066298:In Vitro Techniques; D008991:Monitoring, Physiologic / Q000379:methods*; D019736:Prostheses and Implants
D001672:Biocompatible Materials; D001786:Blood Glucose