Blastic mantle cell lymphoma associated with Burkitt-type translocation and hypodiploidy.
Two elderly men with stage IV mantle cell lymphoma (MCL) rapidly developed a leukaemic phase with unusually high blast counts that proved fatal. One lymph node biopsy showed diffuse MCL, the other blastic morphology. In addition to t(11;14), there were t(8;14) and t(1;19) in case 1 and dup(8)(q24q13) in case 2. Fluorescence in situ hybridization revealed genomic fusion of IgH/MYC genes in case 1 and an extra copy of C-MYC gene in case 2. The genomic alteration of C-MYC oncogene is probably implicated in the blastic transformation and aggressive behaviour of the disease.
Vaishampayan
U N
UN
Division of Hematology Oncology, Department of Medicine, Wayne State University/Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.
Mohamed
A N
AN
Dugan
M C
MC
Bloom
R E
RE
Palutke
M
M
D000368:Aged; D002051:Burkitt Lymphoma / Q000235:genetics; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D008297:Male; D011003:Ploidies; D014178:Translocation, Genetic