Combined effect of captopril and thiazide diuretic on serum lipid profile in hypertensive women.
BACKGROUND
Hypertension has long been recognized as the major risk factor for the development of coronary disease. It was found that the combination of thiazide diuretic and ACE inhibitor has favorable antihypertensive and metabolic effect i.e. the combination reduces the levels of lipid.


METHODS
40 women aged between 35-60 years having systolic blood pressure equal to or greater then 160 mmHg were included in the study. Captopril in a dose of 25-75 mg plus thiazide 25-50 mg orally per day was given in divided doses. Before starting therapy and then after 4th and 10th week of therapy, 5 ml of fasting blood was drawn to analyze lipid profile like serum triglyceride, cholesterol and lipoprotein (HDL and LDL-Cholesterol).


RESULTS
Study observed a marked decrease of blood pressure after taking captopril with diuretics. Level of triglyceride and of HDL and LDL-cholesterol were also significantly changed (P < 0.01) as compared to their controls.


CONCLUSIONS
It was observed that captopril in combination of thiazide diuretics not only decrease blood pressure but also a beneficial effect on lipid profile. Hence further research is needed on large number of patients of both sexes.
Karim
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S
Department of Pharmacology, Fatima Jinnah Medical College, Lahore.
Karim
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S
Begum
A
A
Javed
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N
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001581:Benzothiadiazines; D002216:Captopril / Q000627:therapeutic use*; D004232:Diuretics; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*
D000806:Angiotensin-Converting Enzyme Inhibitors; D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D002216:Captopril