title: Ammocidin, a new apoptosis inducer in ras-dependent cells from Saccharothrix sp. II. Physico-chemical properties and structure elucidation.
abstract: The structure of ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. AJ9571, was elucidated to be as shown in Fig. 1 by NMR and degradation studies. Ammocidin consists of a 20-membered macrolide ring and three deoxy sugars identified as 6-deoxy-L-glucose, D-digitoxose and D-olivomycose.
authors.affiliation: Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Tomikawa
authors.forename: K
authors.initials: K
authors.lastname: Shin-ya
authors.forename: J
authors.initials: J
authors.lastname: Shinozaki
authors.forename: T
authors.initials: T
authors.lastname: Kajiura
authors.forename: H
authors.initials: H
authors.lastname: Seto
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
mesh_terms: D000192:Actinomycetales / Q000254:growth & development / Q000378:metabolism*; D017209:Apoptosis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D018631:ras Proteins / Q000378:metabolism
chemical_list: D018942:Macrolides; C440627:ammocidin; D018631:ras Proteins