Expression of immediate early genes in sensory ganglia.
C-Jun and c-Fos belong to the family of immediate early genes. Apart from their role as transcription factors, a basal expression was shown for them in central nervous system tissues. The expression of c-Jun and c-Fos in sensory ganglia of guinea pig, rat and murine sensory ganglia was examined under normal, unstimulated conditions by quantitative double-immunohistochemistry. 4.6 +/- 2.8% of neuron-specific protein gene-product 9.5 -positive cells in nodose ganglia, 51.6 +/- 2.1% in jugular ganglia, 46.4 +/- 3.0% in trigeminal ganglia and 42.5 +/- 1.3% of cervical dorsal root ganglia neurons were positive for c-Jun in the guinea pig (less than 1% for c-Fos). In rat and mouse, less than 1% of the sensory neurons exhibited c-Jun and c-Fos-immunoreactivity. The high basal expression of c-Jun in guinea pig sensory neurons suggests that in this species the presence of c-Jun does not only depend on specific stimulation and is not exclusively associated with neuronal plasticity of gene expression and functional changes.
Groneberg
D A
DA
Division of Allergy Research, Biomedical Research Center, Charité Medical School, Humboldt University of Berlin, Germany. david.groneberg@charite.de
Wiegand
S
S
Dinh
Q T
QT
Peiser
C
C
Springer
J
J
Fischer
A
A
D000818:Animals; D017950:Ganglia, Sensory / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D016758:Genes, jun; D006168:Guinea Pigs; D017874:Immediate-Early Proteins / Q000235:genetics*; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D009620:Nodose Ganglion / Q000166:cytology / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012668:Trigeminal Ganglion / Q000166:cytology / Q000378:metabolism
D017874:Immediate-Early Proteins; D016755:Proto-Oncogene Proteins c-jun