[Studies on Epstein-Barr virus in patients with primary sinonasal non-Hodgkin's lymphoma].
OBJECTIVE
To study the relationship between Epstein-Barr virus (EBV) infection and primary sinonasal non-Hodgkin's lymphoma.


METHODS
Using polymerase chain reaction (PCR) method, 22 patients with primary sinonasal non-Hodgkin's lymphoma (NHL), including 13 tumours of T cell type and 9 of B cell type, and mucosa from twenty cases of nasonasosinusitis were tested for the presence of Epstein-Barr virus (EBV) DNA.


RESULTS
The results showed that 14 of 22 non-Hodgkin's lymphoma (63.6%) and 4 of 20 nasonasosinusitis mucosa (20%) were EBV-DNAase gene positive (9 T cell type and 5 B cell type). The difference between non-Hodgkin's lymphoma and nasal mucosa was statistically significant (P < 0.005).


CONCLUSIONS
These results suggest that EBV is not only present in B lymphocyte lymphomas but also in T lymphocyte lymphomas.
Li
T
T
First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510089.
Qiu
Q
Q
Li
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000032:analysis*; D003851:Deoxyribonucleases / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000821:virology*; D016399:Lymphoma, T-Cell / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000821:virology
D004279:DNA, Viral; D003851:Deoxyribonucleases