Influence of thoracic sympathectomy on cardiac induced oscillations in tissue blood volume.
The photoplethysmographic (PPG) signal, which measures cardiac-induced changes in tissue blood volume by light transmission measurements, shows spontaneous fluctuations. In this study, PPG was simultaneously measured in the right and left index fingers of 16 patients undergoing thoracic sympathectomy, and, from each PPG pulse, the amplitude of the pulse (AM) and its maximum (BL) were determined. The parameter AM/BL is proportional to the cardiac-induced blood volume increase, which depends on the arterial wall compliance. AM/BL increased after the thoracic sympathectomy treatment (for male patients, from 2.60+/-1.49% to 4.81+/-1.21%), as sympathetic denervation decreases arterial tonus in skin. The very low-frequency (VLF) fluctuations of BL or AM showed high correlation (0.90+/-0.11 and 0.92+/-0.07, respectively) between the right and left hands before the thoracic sympathectomy, and a significant decrease in the right-left correlation coefficient (to 0.54+/-0.22 and 0.76+/-0.20, respectively) after the operation. The standard deviation of the BL or AM VLF fluctuations also reduced after the treatment, indicating sympathetic mediation of the VLF PPG fluctuations. The study also shows that the analysis of the PPG signal and the VLF fluctuations of the PPG parameters enable the assessment of the change in sympathetic nervous system activity after thoracic sympathectomy.
Nitzan
M
M
Department of Physics/Electro-Optics, Jerusalem College of Technology, Israel. nitzan@mail.jct.ac.il
Babchenko
A
A
Shemesh
D
D
Alberton
J
J
D000293:Adolescent; D000328:Adult; D001810:Blood Volume / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000098:blood supply; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D017156:Photoplethysmography; D011184:Postoperative Period; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013900:Thoracic Nerves / Q000601:surgery*