Modification of uterotropic effect of estrogens by whole-body gamma-irradiation.
The effect of gamma-irradiation on the realization of the effects of estrogens was studied on rats treated with N-acetylcysteine, vitamins C and E, melatonin, and carnosine or subjected to forced swimming in a training mode. Irradiation (0.2 Gy) in combination with estrogens and without correction therapy induced genotoxic changes in the uterus, while irradiation in a higher dose (2 Gy) predominantly potentiated the hormonal effect of estrogens. Correction of the revealed abnormalities was achieved mainly with carnosine. The peculiarities of "estrogen toggle (re-targeting) effect" under the effect of gamma-irradiation and its elimination differed from those induced by ethanol intake or tobacco smoking, which is important for understanding the mechanisms of hormone-induced carcinogenesis.
Bershtein
L M
LM
N. N. Petrov Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg.
Tsyrlina
E V
EV
Poroshina
T E
TE
Gamayunova
V B
VB
Solntseva
O S
OS
Kalinina
N M
NM
Ivanov
S D
SD
Kovalenko
I G
IG
Vasil'ev
D A
DA
D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D002336:Carnosine / Q000494:pharmacology; D002467:Cell Nucleus / Q000528:radiation effects; D002784:Cholesterol / Q000097:blood; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D004958:Estradiol / Q000097:blood / Q000633:toxicity*; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D008550:Melatonin / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming; D013997:Time Factors; D014599:Uterus / Q000187:drug effects* / Q000528:radiation effects* / Q000648:ultrastructure; D014916:Whole-Body Irradiation / Q000009:adverse effects; D024502:alpha-Tocopherol / Q000494:pharmacology
D002273:Carcinogens; D004958:Estradiol; D002336:Carnosine; D002784:Cholesterol; D024502:alpha-Tocopherol; D008550:Melatonin; D001205:Ascorbic Acid; D000111:Acetylcysteine