Dendritic cell subsets and costimulation for effector T-cell responses.
The past year has seen major advances in the understanding of dendritic cell biology and of the costimulatory molecules that dendritic cells use to prime effector T cells and memory T cells. Recent work has revealed the specialization between different dendritic cell subsets and how this relates to their different functions in optimizing T-cell help for antibody responses and inflammatory T-cell responses.
Lane
P J
PJ
MRC Centre for Immune Regulation, Department of Immunology and Infection, The Medical School, University of Birmingham, UK. p.j.l.lane@bham.ac.uk
McConnell
F M
FM
D000818:Animals; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000254:growth & development; D011971:Receptors, Immunologic / Q000276:immunology / Q000502:physiology; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology / Q000502:physiology
D011971:Receptors, Immunologic; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; C505716:TNFRSF4 protein, human; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7