title: A case of multiple atypical adenomatous hyperplasia of the lung detected by computed tomography.
abstract: Multiple atypical adenomatous hyperplasia (AAH) of both lungs in a 72-year-old male, detected by computed tomography, is reported. The lesions of the right lung were resected for diagnosis via video-assisted thoracoscopic surgery (VATS). The resected specimen had 22 AAH lesions up to 10 mm in size. For nine of these lesions, the expressions of carcinoembryonic antigen (CEA), c-erbB-2 oncoprotein and p53 gene product were examined by immunohistochemistry and the loss of heterozygosity (LOH) on chromosomes was investigated by polymerase chain reaction analysis. These lesions showed a variety of expressions for CEA, c-erbB-2 and p53 oncoprotein. Three of the nine lesions showed LOH on chromosome 13q, although this was not exhibited in the largest one. These results indicate that each AAH in this case has independent genetic abnormalities and is multicentric.
authors.affiliation: Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nomori
authors.forename: H
authors.initials: H
authors.lastname: Horio
authors.forename: T
authors.initials: T
authors.lastname: Naruke
authors.forename: K
authors.initials: K
authors.lastname: Suemasu
authors.forename: S
authors.initials: S
authors.lastname: Morinaga
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
mesh_terms: D018255:Adenomatosis, Pulmonary / Q000000981:diagnostic imaging* / Q000235:genetics / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000601:surgery; D008297:Male; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000097:blood; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53