New halogenated marine prostanoids with cytotoxic activity from the Okinawan soft coral Clavularia viridis.
Five new halogenated prostanoids 1-4 and 6 were isolated from the Okinawan soft coral Clavularia viridis. The gross structure of 1 was elucidated mainly on the basis of NMR spectral data. The relative and absolute configurations were determined by analysis of NOESY and CD data, chemical conversion, and the modified Mosher's method. The structures of 2-4 and 6 were deduced by comparison of their spectral data with those of 1. Compound 1 demonstrated cytotoxic activity.
Watanabe
K
K
School of Life Science, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. kinzo@ls.toyaku.ac.jp
Sekine
M
M
Takahashi
H
H
Iguchi
K
K
D000465:Algorithms; D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects; D002942:Circular Dichroism; D003063:Cnidaria / Q000737:chemistry*; D015179:Colorectal Neoplasms; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D007945:Leukemia, Lymphoid; D008168:Lung / Q000166:cytology / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011453:Prostaglandins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D006846:Hydrocarbons, Halogenated; D011453:Prostaglandins