title: Acetylated DNA-damaging clerodane diterpenes from Casearia sylvestris.
abstract: In addition to the known diterpene casearin G (1), two new clerodane diterpene casearins type, casearin S (2) and casearin T (3), were isolated from an acetylated bioactive CH(2)Cl(2)/MeOH extract from leaves of Casearia sylvestris. The diterpenes 1-3 exhibited moderate but selective activity towards the DNA-repair deficient yeast Saccharomyces cerevisiae mutants RAD 52YK and RS 321. The structures of 1-3 were established on the basis of NMR spectroscopic experiments
authors.affiliation: Instituto de Química, Universidade Estadual Paulista, CP 355, 14800-900, SP, Araraquara, Brazil
authors.forename: Paulo Roberto F.
authors.initials: PR
authors.lastname: de Carvalho
authors.forename: Maysa
authors.initials: M
authors.lastname: Furlan
authors.forename: Maria Claudia M.
authors.initials: MC
authors.lastname: Young
authors.forename: David G. I.
authors.initials: DG
authors.lastname: Kingston
authors.forename: Vanderlan da S.
authors.initials: VS
authors.lastname: Bolzani