A complex linkage in the developmental pathway of endothelial and hematopoietic cells.
During normal vertebrate development, hematopoietic and endothelial cells form closely situated and interacting populations. Although the close proximity of cells to each other does not necessarily mean that they are relatives, accumulating evidence indicates that hematopoietic and endothelial cells are indeed close kin; they share common progenitors and each is able to become the other under certain circumstances. This article summarizes recent advances in the developmental relationship between hematopoietic and endothelial cells.
Nishikawa
S I
SI
Department of Molecular Genetics, Graduate School of Medicine, Kyoto University and Riken Center for Developmental Biology, Shogoin-Kawaharacho 53, Sakyo-ku, Kyoto, 606-8507, Japan. snishika@virus.Kyoto-u.ac.jp
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D001853:Bone Marrow / Q000254:growth & development*; D002454:Cell Differentiation; D019070:Cell Lineage; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000502:physiology; D004330:Drosophila / Q000254:growth & development; D004730:Endothelium, Vascular / Q000254:growth & development*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D060588:LIM Domain Proteins; D008667:Metalloproteins / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D011518:Proto-Oncogene Proteins; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D051792:Basic Helix-Loop-Helix Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D060588:LIM Domain Proteins; D008667:Metalloproteins; D011518:Proto-Oncogene Proteins; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors; C513188:Lmo2 protein, mouse; C493726:Runx1 protein, mouse; C489366:Tal1 protein, mouse