title: How to make sense of pertussis immunogenicity data.
abstract: Studies on serologic correlates to protection in pertussis were reviewed. Trials in the 1950s showed that agglutinogen titers correlated to protection of whole-cell vaccines, but postvaccination antibodies against pertussis toxin (PT) and against filamentous hemagglutinin did not in a later trial of acellular vaccines. However, in household studies nested in 2 recent trials, preexposure antibody levels against pertactin and against fimbriae correlated with protection against typical and mild pertussis, and anti-PT correlated only with protection against typical pertussis. These findings could be used by regulatory agencies to license pertussis vaccines. A reference laboratory for pertussis should distribute panels to control interlaboratory variation in recommended assays, and a minimal response should be set for each pertussis antigen. We conclude that 2 studies have shown correlates between measurable anti-pertactin, anti-fimbriae, and anti-PT antibody levels at exposure and individual protection against pertussis. We suggest that postvaccination response rates may be used as surrogate markers of protection.
authors.affiliation: Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Patrick.olin@smi.ki.se
authors.forename: P
authors.initials: P
authors.lastname: Olin
authors.forename: H O
authors.initials: HO
authors.lastname: Hallander
authors.forename: L
authors.initials: L
authors.lastname: Gustafsson
authors.forename: E
authors.initials: E
authors.lastname: Reizenstein
authors.forename: J
authors.initials: J
authors.lastname: Storsaeter
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002986:Clinical Trials as Topic; D010861:Fimbriae, Bacterial / Q000276:immunology; D006801:Humans; D037342:Pertussis Toxin; D010567:Pertussis Vaccine / Q000276:immunology*; D012015:Reference Standards; D010566:Virulence Factors, Bordetella / Q000276:immunology; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D015415:Biomarkers; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; C068929:pertactin; D037342:Pertussis Toxin