title: Intricacies in ATP-dependent clamp loading: variations across replication systems.
abstract: DNA replication requires the coordinated effort of many proteins to create a highly processive biomachine able to replicate entire genomes in a single process. The clamp proteins confer on replisomes this property of processivity but in turn require clamp loaders for their functional assembly onto DNA. A more detailed view of the mechanisms for holoenzyme assembly in replication systems has been obtained from the advent of novel solution experiments and the appearance of low- and high-resolution structures for the clamp loaders.
authors.affiliation: Department of Chemistry, 414 Wartik Laboratory, Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Trakselis
authors.forename: S J
authors.initials: SJ
authors.lastname: Benkovic
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D017122:Bacteriophage T4 / Q000201:enzymology; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism* / Q000648:ultrastructure*; D004926:Escherichia coli / Q000201:enzymology; D008958:Models, Molecular; D020409:Molecular Motor Proteins
chemical_list: D020409:Molecular Motor Proteins; D000255:Adenosine Triphosphate; D004259:DNA-Directed DNA Polymerase