17-Hydroxylase: an evaluation of the present view of its catalytic role in steroidogenesis.
This survey analyses the evidence that has led to the belief that the catalytic role of 17-hydroxylase in the biosynthesis of cortisol, estradiol, testosterone and dehydroepiandrosterone is confined to two chemical reactions: pregnenolone-->17-hydroxypregnenolone-->dehydroepiandrosterone. This analysis suggests that the evidence supporting this view is not compelling enough to accept it unquestioningly. Different interpretations of the data can suggest other catalytic roles for 17-hydroxylase that are worthy of consideration. One such alternative is proposed.
Lieberman
S
S
Department of Obstetrics and Gynecology, The St. Luke's-Roosevelt Institute for Health Sciences, New York, NY 10019, USA.
Warne
P A
PA
D000818:Animals; D002384:Catalysis; D006801:Humans; D013254:Steroid 17-alpha-Hydroxylase / Q000378:metabolism*; D013256:Steroids / Q000096:biosynthesis*
D013256:Steroids; D013254:Steroid 17-alpha-Hydroxylase