[Allogeneic bone marrow transplantation for chronic myeloid leukemia: 118 cases analysis].
OBJECTIVE
To analyze the outcome of allogeneic bone marrow transplantation (allo-BMT) performed for chronic myeloid leukemia (CML) patients.


METHODS
One hundred and eighteen CML patients received allo-BMT with conditioning regimens of TBI or modified BU/CY. The pre-BMT situations were, 91 cases in first chronic phase (CP1), 19 in accelerating phase (AP), 2 in blast crisis (BC) and 6 in advanced CP (> CP2).


RESULTS
One hundred and nine patients were successfully engrafted. The probabilities of 5 year survival for CP1 and AP patients were 69.6% and 51.0%, and 5 year relapse rates were 3.2% and 12.5%, respectively.


CONCLUSIONS
Disease stage, conditioning regimen and splenomegaly did not affect the time for engraftment. For patients in CP1, splenomegaly was positively correlated with relapse. There was no difference between the effect of the two conditioning regimens on the prognosis.
Liu
D
D
Institute of Hematology, Beijing Medical University, Beijing 100044.
Guo
N
N
Zhang
Y
Y
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000401:mortality; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D015996:Survival Rate; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous