title: Multiple myeloma-associated amyloidosis manifesting as fulminant hepatic failure.
abstract: We report a case of amyloidosis associated with K light chain multiple myeloma in a 42-year-old African American man. The patient initially had mild dyspepsia, which rapidly progressed to include anorexia, fulminant hepatic failure, and death within 9 weeks. This is only the fourth reported case of hepatic failure from myeloma-associated amyloidosis and the second reported case of light chain myeloma with amyloidosis resulting in a progressive clinical course of hepatic failure. Our patient was unique in that, despite severe disease, he had mild symptoms without laboratory abnormalities until 2 weeks prior to death.
authors.affiliation: Department of Internal Medicine, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA.
authors.forename: N C
authors.initials: NC
authors.lastname: Ales
authors.forename: J T
authors.initials: JT
authors.lastname: Daniels
authors.forename: E R
authors.initials: ER
authors.lastname: Frizell
authors.forename: J M
authors.initials: JM
authors.lastname: Koff
authors.forename: K J
authors.initials: KJ
authors.lastname: Kaplan
authors.forename: G W
authors.initials: GW
authors.lastname: Wortmann
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D017093:Liver Failure / Q000209:etiology* / Q000473:pathology; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology