Visual pathways following cerebral hemispherectomy.
The anatomical consequences of unilateral cerebral hemispherectomy in some animal models are reviewed. We have shown that the retinogenigulate pathway undergoes severe degenerative changes in hemispherectomized monkeys, greater than those shown in cats and we proposed that remaining retinal terminals to the dorsal lateral geniculate nucleus have little potential for conveying visual information any further. All subdivisions of the pulvinar undergo severe degeneration following hemispherectomy showing that the ascending tectofugal pathway is also shut off. On the other hand, the retina subserving the blind field is not depleted of ganglion cells which still send normal appearing terminals to the midbrain pretectum and superior colliculus. Visual information from the blind hemifield can thus gain access to the brain and could potentially reach the contralateral cerebral cortex through the midbrain commissure and possibly through thalamic commissural cells.
Boire
D
D
Ecole d'Optométrie, Université de Montréal, CP, 6128, succursale Centre-ville, Montréal, PQ, H3C 3J7 Canada.
Théoret
H
H
Ptito
M
M
D000818:Animals; D001921:Brain / Q000503:physiopathology* / Q000601:surgery*; D008959:Models, Neurological; D011184:Postoperative Period; D012160:Retina / Q000503:physiopathology; D009435:Synaptic Transmission; D014793:Visual Cortex / Q000601:surgery; D014795:Visual Pathways / Q000503:physiopathology*