title: Intussusception due to Yersinia enterocolitica enterocolitis in a patient with beta-thalassemia.
abstract: Patients who are homozygous for thalassemia major are at risk for Yersinia enterocolitica infections. We present a case of a 4-year-old child with intussusception of the terminal ileum whose past medical history was significant for beta-thalassemia. His monthly blood transfusions for this condition may have put him at risk for Y enterocolitica enterocolitis. The pathogenesis of this disease relates to the role of iron as an essential growth factor for Yersinia, and this patient's transfusions left him in an iron-overloaded state, despite treatment with Desferal. Our patient's unusual presentation of intussusception was secondary to the mass effect caused by lymphoid hyperplasia, specifically hypertrophied Peyer's patches in the ileum caused by Y enterocolitica infection. To our knowledge, this is the first such case of intussusception caused by Yersinia to be reported.
authors.affiliation: Department of Pathology, Orlando Regional Medical Center, 1414 South Orange Ave, Orlando, FL 32806, USA. mghansen1@msn.com
authors.forename: M G
authors.initials: MG
authors.lastname: Hansen
authors.forename: G
authors.initials: G
authors.lastname: Pearl
authors.forename: M
authors.initials: M
authors.lastname: Levy
mesh_terms: D002675:Child, Preschool; D003676:Deferoxamine / Q000627:therapeutic use; D004760:Enterocolitis / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D006984:Hypertrophy; D007082:Ileum / Q000473:pathology / Q000601:surgery; D007443:Intussusception / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D007502:Iron Chelating Agents / Q000627:therapeutic use; D019190:Iron Overload / Q000150:complications / Q000188:drug therapy; D008297:Male; D010581:Peyer's Patches / Q000473:pathology; D065227:Transfusion Reaction; D015009:Yersinia Infections / Q000473:pathology; D015008:Yersinia enterocolitica; D017086:beta-Thalassemia / Q000150:complications* / Q000628:therapy
chemical_list: D007502:Iron Chelating Agents; D003676:Deferoxamine