title: Autistic spectrum disorders in preschool children.
abstract: OBJECTIVE
  To review existing data on early signs of autistic spectrum disorders (ASD) and on how these disorders can be distinguished from other atypical patterns of development, and to describe a developmental surveillance approach that family physicians can use to ensure that children with these diagnoses are detected as early as possible.
  
  
  METHODS
  MEDLINE was searched from January 1966 to July 2000 using the MeSH terms autistic disorder/diagnosis AND diagnosis, differential AND (infant OR child, preschool). Articles were selected based on relevance to developmental surveillance in primary care and on experimental design, with emphasis on prospective studies with systematic measurement procedures using up-to-date diagnostic criteria.
  
  
  RESULTS
  Autistic spectrum disorders are characterized by impairments in social interaction and verbal and nonverbal communication, and by preferences for repetitive interests and behaviours. Early signs that distinguish ASD from other atypical patterns of development include poor use of eye gaze, lack of gestures to direct other people's attention (particularly to show things of interest), diminished social responsiveness, and lack of age-appropriate play with toys (especially imaginative use of toys). Careful attention to parents' concerns and specific inquiry into and observation of how children interact, communicate, and play will help ensure that early signs are detected during regular health maintenance visits.
  
  
  CONCLUSIONS
  Family physicians have an important role in early identification of children with ASD. Early diagnosis of these disorders is essential to ensure timely access to interventions known to improve outcomes for these children.
authors.affiliation: McMaster University, Hamilton, Ont. zwaigenb@fhs.mcmaster.ca
authors.forename: L
authors.initials: L
authors.lastname: Zwaigenbaum
mesh_terms: D001321:Autistic Disorder / Q000150:complications / Q000175:diagnosis*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis; D003937:Diagnosis, Differential; D005194:Family Practice; D006801:Humans; D007223:Infant; D007398:Interpersonal Relations; D007805:Language Development Disorders / Q000209:etiology; D009483:Neuropsychological Tests