Development of dirhodium(II)-catalyzed generation and enantioselective 1,3-dipolar cycloaddition of carbonyl ylides.
Catalytic, enantioselective, tandem carbonyl ylide formation/cycloaddition of 2-diazo-3,6-diketoester 2 with the use of dirhodium tetrakiscarboxylate and tetrakisbinaphtholphosphate catalysts to give the cycloadducts 3 in good yields and up to 90% ee is described.
Hodgson
D M
DM
Department of Chemistry, University of Oxford, UK. david.hodgson@chem.ox.ac.uk
Stupple
P A
PA
Pierard
F Y
FY
Labande
A H
AH
Johnstone
C
C