title: Temporal associations between coughing or wheezing and acid reflux in asthmatics.
abstract: OBJECTIVE
  The pulmonary symptoms of patients with lung disease may be ascribed to gastro-oesophageal reflux although a causal relationship between acid reflux and coughing or wheezing has not been proved. Does cough cause reflux or does reflux cause cough? The aim of this study was to evaluate 24 hour oesophageal pH tracings of asthmatics with gastro-oesophageal reflux to determine the temporal association between acid reflux and coughing or wheezing.
  
  
  METHODS
  The oesophageal tracings of 128 asthmatics from the outpatient clinics who underwent oesophagogastroduodenoscopy, oesophageal manometry, and 24 hour oesophageal pH monitoring were analysed. Three possible temporal relationships between the occurrence of acid reflux and the occurrence of coughs or wheezes were evaluated: (1) pulmonary symptoms preceding reflux; (2) reflux preceding pulmonary symptoms; and (3) unrelated occurrence of both events.
  
  
  RESULTS
  Of 128 asthmatics, 53 recorded five or more coughs and 19 recorded three or more wheezes during the 24 hour recording period. Mean acid contact time was similar in asthmatics with and without pulmonary symptoms (12.2 (1.2)% v 10.4 (0.6)%). Of all coughs and wheezes, 46% and 48%, respectively, were associated with acid reflux. For the individual asthmatic, the likelihood of reflux induced coughing increased as the number of coughs increased.
  
  
  CONCLUSIONS
  Half of all coughs and wheezes in asthmatics are associated with acid reflux into the oesophagus. While an occasional coughing episode can lead to reflux, it is rather the reflux episode in the vast majority of instances that leads to cough.
authors.affiliation: Department of Veterans Affairs Medical Center, Albuquerque, New Mexico 87108, USA.
authors.forename: B
authors.initials: B
authors.lastname: Avidan
authors.forename: A
authors.initials: A
authors.lastname: Sonnenberg
authors.forename: T G
authors.initials: TG
authors.lastname: Schnell
authors.forename: S J
authors.initials: SJ
authors.lastname: Sontag
mesh_terms: D001249:Asthma / Q000150:complications* / Q000503:physiopathology; D003371:Cough / Q000150:complications* / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008991:Monitoring, Physiologic; D012135:Respiratory Sounds / Q000503:physiopathology*; D013997:Time Factors