title: Is there any significance for intracellular crystals in plasma cells from patients with monoclonal gammopathies?
abstract: Several plasma cells morphological changes have been described in monoclonal gammopathies, including intracytoplasmic crystals. We report one case of indolent kappa-chain multiple myeloma with renal insufficiency, featuring plasma cells with Auer-rod-like intracytoplasmic inclusions. The relationship between such aberrations and those found in multiple-myeloma-associated adult Fanconi syndrome is discussed. The significance of intracellular storage and crystallisation of immunoglobulin within plasma cells remains partially unknown.
authors.affiliation: Laboratoire d'Hématologie, Centre Hospitalier Universitaire, Angers, France. JaGardais@chu-angers.fr
authors.forename: J
authors.initials: J
authors.lastname: Gardais
authors.forename: F
authors.initials: F
authors.lastname: Geneviève
authors.forename: C
authors.initials: C
authors.lastname: Foussard
authors.forename: V
authors.initials: V
authors.lastname: Delisle
authors.forename: M
authors.initials: M
authors.lastname: Zandecki
mesh_terms: D000368:Aged; D001797:Blood Protein Electrophoresis; D001853:Bone Marrow / Q000473:pathology; D003460:Crystallization; D004587:Electrophoresis, Agar Gel; D005198:Fanconi Syndrome / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007677:Kidney Function Tests; D009101:Multiple Myeloma / Q000097:blood / Q000150:complications / Q000473:pathology*; D009194:Myeloma Proteins / Q000032:analysis*; D010014:Osteolysis / Q000209:etiology; D010265:Paraproteinemias / Q000150:complications / Q000473:pathology; D010950:Plasma Cells / Q000648:ultrastructure*
chemical_list: D007145:Immunoglobulin kappa-Chains; D009194:Myeloma Proteins