title: The relationship between the levels of granulocyte colony-stimulating factor and leukocytosis induced by all-trans retinoic acid in acute promyelocytic leukemia.
abstract: OBJECTIVE
  To explore the mechanism of leukocytosis.
  
  
  METHODS
  Enzyme linked immunosorbent assay (ELISA) method was used for detecting levels of serum granulocyte colony-stimulating factor (G-CSF) in 47 cases of acute promyelocytic leukemia (APL) during the treatment with all-trans retinoic acid (ATRA).
  
  
  RESULTS
  The peak of increased serum G-CSF level occurred on the 9th day, and WBC number was the highest on the 11th day. After ATRA treatment, both serum G-CSF level and WBC number increased in 68.1% of the cases. In 19.2% of the cases treated, serum G-CSF level was increased but without obvious change in WBC number, and the reverse was true in 12.7% of the cases.
  
  
  CONCLUSIONS
  Serum G-CSF level was statistically correlated to the number of WBC, promyelocytes and its late stage by Spearman's rank-order correlation coefficient.
authors.affiliation: Laborotory of Cellularbiology, Shanghai Institute of Hematology, Shanghai Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: G
authors.initials: G
authors.lastname: Sun
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: R
authors.initials: R
authors.lastname: Zhou
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Shen
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood* / Q000188:drug therapy; D007964:Leukocytosis / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor; D014212:Tretinoin