title: Ultrasound-guided core needle biopsy as an initial diagnostic test for palpable breast masses.
abstract: OBJECTIVE
  To determine the role of ultrasound (US)-guided core needle biopsy as an initial diagnostic test for palpable breast masses.
  
  
  METHODS
  Ninety-eight consecutive patients, each with a palpable breast mass, were referred for US-guided core biopsy by a multidisciplinary team of physicians who specialize in the care of breast diseases. All palpable breast masses were clearly visible on high-resolution US. Ninety-nine core needle biopsies were performed under local anesthesia with use of freehand technique, mostly in an outpatient setting. Core needle path through each mass was documented in two orthogonal sections. A mean of 3.4 tissue core samples (range, 1-7) were obtained in each patient.
  
  
  RESULTS
  Core needle biopsy resulted in the diagnosis of 66 malignancies, two cases of atypical ductal hyperplasia (ADH), and 30 benign diseases of the breast. Surgery with curative intent was performed in 63 breast malignancies and excisional biopsies were performed for 10 benign diseases (two cases of ADH and eight benign lesions). Twenty-five breast masses were managed nonoperatively: chemotherapy was performed in three locally advanced breast cancers and 3-year follow-up was conducted for 22 benign lesions. Malignancies were correctly diagnosed in all cases. No malignancy was discovered at surgery or during clinical follow-up of ADH and no benign breast lesions were diagnosed by core needle biopsy. US-guided core needle biopsy is 100% sensitive and specific for palpable breast malignancies, with no false-positive results. A puncture site ecchymosis was the only morbidity or complication noted.
  
  
  CONCLUSIONS
  US-guided core needle biopsy is a safe and accurate first diagnostic test for palpable breast masses that require tissue proof.
authors.affiliation: Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chang Gung University, Tao Yuan, Taiwan, Republic of China. kmyeow@adm.cgmh.org.tw
authors.forename: K M
authors.initials: KM
authors.lastname: Yeow
authors.forename: Y F
authors.initials: YF
authors.lastname: Lo
authors.forename: C S
authors.initials: CS
authors.lastname: Wang
authors.forename: H K
authors.initials: HK
authors.lastname: Chang
authors.forename: C S
authors.initials: CS
authors.lastname: Tsai
authors.forename: C
authors.initials: C
authors.lastname: Hsueh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods*; D001941:Breast Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D018084:Ultrasonography, Interventional; D016217:Ultrasonography, Mammary