Brownian dynamics study of an open-state KcsA potassium channel.
Three-dimensional Brownian dynamics simulations are used to study conductance of the KcsA potassium channel using the known crystallographic structure. Employing an open-state channel created by molecular dynamics simulations, current-voltage and current-concentration curves broadly consistent with experimental measurements are obtained. In the absence of an applied potential, the channel houses three potassium ions at positions that are in close agreement with X-ray diffraction maps.
Allen
T W
TW
Department of Physics, Australian National University, 0200, Canberra, ACT, Australia.
Chung
S H
SH
D001426:Bacterial Proteins; D004553:Electric Conductivity; D008962:Models, Theoretical; D015221:Potassium Channels / Q000737:chemistry*; D011199:Potentiometry; D055672:Static Electricity
D001426:Bacterial Proteins; D015221:Potassium Channels; C107790:prokaryotic potassium channel