Dietary sesame seeds elevate alpha- and gamma-tocotrienol concentrations in skin and adipose tissue of rats fed the tocotrienol-rich fraction extracted from palm oil.
The metabolism of tocotrienol remains unclear. We studied the distribution of tocotrienol in rats fed the tocotrienol-rich fraction extracted from palm oil. We have previously shown that dietary sesame seeds markedly elevate the tocopherol concentration in rats. In this study, we also examined the effect of dietary sesame seeds on the tocotrienol concentration. In experiment 1, rats (4-wk-old) were fed the diet with alpha-tocopherol alone or with alpha- and gamma-tocotrienols. In experiment 2, the effect of dietary sesame seeds on tocopherol and tocotrienol concentrations in rats fed the diet with tocopherol and tocotrienol was studied. The rats were fed the experimental diet for 8 wk in both experiments. alpha- and gamma-Tocotrienols accumulated in the adipose tissue and skin, but not in plasma or other tissues, of the rats fed tocotrienols. Dietary sesame seeds elevated (P < 0.05) tocotrienol concentrations in the adipose tissue and skin, but did not affect their concentrations in other tissues or in plasma. The gamma-tocopherol concentration in all tissues and plasma of rats fed gamma-tocopherol was extremely low but was elevated (P < 0.05) in many tissues by feeding sesame seeds. These data suggest that the transport and tissue uptake of vitamin E isoforms are different. Dietary sesame seeds elevate the concentrations of both tocopherols and tocotrienols.
Ikeda
S
S
Department of Food and Nutrition, School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan.
Toyoshima
K
K
Yamashita
K
K
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002839:Chromans / Q000378:metabolism* / Q000493:pharmacokinetics; D004032:Diet; D008297:Male; D009929:Organ Size / Q000187:drug effects; D000073878:Palm Oil; D010938:Plant Oils; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D012867:Skin / Q000378:metabolism*; D014018:Tissue Distribution; D024508:Tocotrienols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000493:pharmacokinetics
D002839:Chromans; D010938:Plant Oils; D024508:Tocotrienols; D014810:Vitamin E; C013649:plastochromanol 8; D000073878:Palm Oil; C082032:tocotrienol, alpha