title: Acquired methemoglobinemia in anemic cattle infected with Theileria sergenti.
abstract: To investigate the mechanism of anemia accompanying Japanese bovine theileriosis, we examined whether production of methemoglobin (MetHB), an indicator of erythrocyte oxidation, was associated with anemia in cattle experimentally infected with Theileria sergenti. The percentage of MetHB, which is an oxidized form of hemoglobin, increased according to the onset of anemia. During severe anemia, high levels of acquired methemoglobinemia were observed in all infected cattle. A significant correlation (r=-0.649; P<0.01) between an increase in MetHB concentration and a decrease in packed cell volume (PCV) was observed. It was considered that hemoglobin oxidation may be one of the aggravating factors of anemia in T. sergenti infection.
authors.affiliation: Hokkaido Research Station, National Institute of Animal Health, 4 Hitsujigaoka, Toyohira, Sapporo 062-0045, Japan. shiono@affrc.go.jp
authors.forename: H
authors.initials: H
authors.lastname: Shiono
authors.forename: Y
authors.initials: Y
authors.lastname: Yagi
authors.forename: P
authors.initials: P
authors.lastname: Thongnoon
authors.forename: N
authors.initials: N
authors.lastname: Kurabayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Chikayama
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
authors.forename: I
authors.initials: I
authors.lastname: Nakamura
mesh_terms: D000743:Anemia, Hemolytic / Q000097:blood / Q000469:parasitology / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood* / Q000175:diagnosis / Q000469:parasitology; D004912:Erythrocytes / Q000378:metabolism* / Q000469:parasitology; D008297:Male; D008706:Methemoglobin / Q000096:biosynthesis; D008708:Methemoglobinemia / Q000175:diagnosis / Q000662:veterinary*; D010084:Oxidation-Reduction; D016794:Theileria / Q000502:physiology; D013801:Theileriasis / Q000097:blood* / Q000150:complications; D013997:Time Factors
chemical_list: D008706:Methemoglobin