title: Postantibiotic effects of ABT-773 and amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae.
abstract: This study determined the postantibiotic effect (PAE) of ABT-773 versus that of amoxicillin-clavulanate against clinical isolates of Streptococcus pneumoniae and Haemophilus influenzae. The PAEs of ABT-773 and amoxicillin-clavulanate ranged from 2.3 to 6.0 h and 0 to 2.2 h against S. pneumoniae and from 2.7 to 9.1 h and 0 to 0.8 h against H. influenzae, respectively.
authors.affiliation: The University of Houston College of Pharmacy, Department of Clinical Sciences and Administration, Houston, Texas, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Neuhauser
authors.forename: J L
authors.initials: JL
authors.lastname: Prause
authors.forename: L H
authors.initials: LH
authors.lastname: Danziger
authors.forename: S L
authors.initials: SL
authors.lastname: Pendland
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006192:Haemophilus Infections / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D048628:Ketolides; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics
chemical_list: D048628:Ketolides; D004917:Erythromycin; D019980:Amoxicillin-Potassium Clavulanate Combination; C405499:cethromycin