title: Identification of patients with coronary artery disease by assessing diastolic abnormalities during isometric exercise.
abstract: BACKGROUND
  Previous clinical studies using invasive and noninvasive methods have shown handgrip-induced diastolic abnormalities in patients with coronary artery disease (CAD).
  
  
  OBJECTIVE
  The study was undertaken to determine the utility of Doppler echo- and pressocardiography during hand-grip in discriminating patients with coronary artery disease (CAD) and in those with normal coronary arteries.
  
  
  METHODS
  Both methods were obtained in 96 patients with suspected CAD within 24 h before coronary angiography. An abnormal handgrip-Doppler was defined by an early (E) to late (A) transmitral flow velocities ratio (E/A) < 1 during handgrip and a positive handgrip pressocardiographic test (HAT) by an abnormal increase in the A wave/total excursion or prolongation of the absolute or relative (heart-rate corrected) total relaxation time during isometric exercise.
  
  
  RESULTS
  Of the 96 patients studied, 23 had normal coronary arteries and 73 showed CAD. In patients with normal coronary arteries, handgrip-Doppler showed an abnormal average E/A at rest and during handgrip, whereas all variables of HAT were within normal limits. In patients with CAD, handgrip-Doppler showed only a moderate handgrip-induced increase in average A (+ 19%, p < 0.001), whereas HAT showed a significant (p < 0.001) increase in mean A wave/total excursion (+ 60%) and decrease in the relative total relaxation time (- 17%). Furthermore, handgrip-Doppler and HAT were abnormal in 15 of 23 (65%, specificity 35%) and the HAT in 5 of 23 (22%, specificity 78%) patients with normal coronary arteries, as well as in 57 of 73 (sensitivity 78%) and 69 of 73 (95%) patients with CAD.
  
  
  CONCLUSIONS
  Our study demonstrates that these noninvasive stress tests can become a useful new diagnostic modality for detecting patients with unknown or suspected CAD.
authors.affiliation: University of Athens, Medical School, Department of Cardiology, Hippokration Hospital, Greece.
authors.forename: J
authors.initials: J
authors.lastname: Manolas
authors.forename: C
authors.initials: C
authors.lastname: Chrysochoou
authors.forename: S
authors.initials: S
authors.lastname: Kastelanos
authors.forename: K N
authors.initials: KN
authors.lastname: Aggeli
authors.forename: D B
authors.initials: DB
authors.lastname: Panagiotakos
authors.forename: C
authors.initials: C
authors.lastname: Stefanadis
authors.forename: P
authors.initials: P
authors.lastname: Toutouzas
mesh_terms: D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology; D003971:Diastole; D015150:Echocardiography, Doppler; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic