Vaccines against cysticercosis and hydatidosis.
The recombinant vaccines that have been developed against cysticercosis and hydatidosis in sheep and cattle are remarkable for their effectiveness and are prominent as examples of the very few non-living vaccines against parasitic diseases. Their development has been through practical application of molecular parasitology, utilising immunochemical techniques in antigen identification and recombinant DNA methods in antigen production. This brief overview discusses the contribution of molecular techniques to the successful development of recombinant vaccines against Taenia ovis, Taenia saginata and Echinococcus granulosus as well as the immunological and genomic studies that have arisen from their development.
Lightowlers
M W
MW
Molecular Parasitology Laboratory, Veterinary Clinical Centre, The University of Melbourne, 250 Princes Highway, Werribee, Vic. 3030, Australia. marshall@unimelb.edu.au
Gauci
C G
CG
D000818:Animals; D000947:Antigens, Helminth / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D002417:Cattle; D003551:Cysticercosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D003552:Cysticercus / Q000276:immunology*; D004274:DNA, Recombinant; D004443:Echinococcosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D004446:Echinococcus / Q000276:immunology*; D007120:Immunochemistry; D008967:Molecular Biology / Q000379:methods; D012756:Sheep; D014611:Vaccination / Q000662:veterinary; D014614:Vaccines, Synthetic / Q000235:genetics* / Q000276:immunology
D000947:Antigens, Helminth; D004274:DNA, Recombinant; D014614:Vaccines, Synthetic