Acute Cerebral Artery Constriction in the Spontaneously Hypertensive Rat following Blood and Plasma Administration into the Subarachnoid Space.
The purpose of the present study was to demonstrate, using a vascular casting technique, acute vasoconstrictive changes in the cerebral vasculature 1 h following whole-blood or plasma infusion into the subarachnoid space of conscious spontaneously hypertensive rats. Vascular casts from animals infused (over 20 min) with 0.45 ml of heparinized autologous arterial blood or plasma exhibited incomplete filling, while casts from saline-infused controls exhibited virtually no filling defects. Significant elevations in intracranial pressure were noted in blood, but not in plasma- or saline-infused rats. Two characteristic forms of constriction occurred, depending upon the vessel lumen diameter. Vessels with lumen diameters >100 &mgr;m were flattened longitudinally with deep endothelial nuclear imprints, while smaller vessels had focal circular constrictions resembling beads. Arterial cast filling terminated in vessels with lumen diameters from 70 to 120 &mgr;m with focal signs of constriction at or near the point of cast termination. The results indicate that the presence of both blood and plasma in the subarachnoid space produces acute small-artery constriction. This phenomenon is due to a noncellular blood component and does not correlate with increases in intracranial pressure. Copyright 1996 S. Karger AG, Basel
Acuff
C.G.
CG
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Miss., USA.
Hoskins
G.
G
Moore
N.A.
NA
Rockhold
R.W.
RW