title: Enzyme redesign.
authors.affiliation: Department of Pharmacology, University of Pennsylvania School of Medicine, 135 John Morgan Building, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104-6084, USA. penning@pharm.med.upenn.edu
authors.forename: T M
authors.initials: TM
authors.lastname: Penning
authors.forename: J M
authors.initials: JM
authors.lastname: Jez
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000378:metabolism; D001665:Binding Sites; D002384:Catalysis; D003067:Coenzymes / Q000378:metabolism; D017076:Computer-Aided Design; D016208:Databases, Factual; D019020:Directed Molecular Evolution; D015195:Drug Design; D004789:Enzyme Activation; D004798:Enzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism; D015394:Molecular Structure; D016296:Mutagenesis; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D011487:Protein Conformation; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013237:Stereoisomerism; D013379:Substrate Specificity; D014166:Transferases / Q000378:metabolism
chemical_list: D003067:Coenzymes; D004798:Enzymes; D011506:Proteins; D009243:NAD; D009249:NADP; D000255:Adenosine Triphosphate; D010088:Oxidoreductases; D014166:Transferases; D006867:Hydrolases