Malignant transformation in synovial chondromatosis of the knee?
Although it has been reported, malignant transformation of synovial chondromatosis is rare. We report a case of malignant transformation of synovial chondromatosis in a knee to a low-grade chondrosarcoma, which was treated with synovial excision and total knee replacement. We also present a literature review of the subject. The case illustrates that malignant transformation should be suspected in chronic cases with a sudden exacerbation of symptoms and that interpretation of histology in cartilage lesions is difficult. It also demonstrates that even when guided biopsy techniques are used, the sampling error of a needle biopsy in any large lesion is unavoidable.
Hallam
P
P
Middlesex Hospital, Mortimer Street, London W1N 8AA, UK. pete.orthopod@virgin.net
Ashwood
N
N
Cobb
J
J
Fazal
A
A
Heatley
W
W
D001859:Bone Neoplasms / Q000473:pathology*; D015838:Chondromatosis, Synovial / Q000473:pathology*; D002813:Chondrosarcoma / Q000473:pathology*; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008297:Male; D008875:Middle Aged