title: An antibody against anemia-inducing substance inhibits cation influx in red blood cells from cancer patients.
abstract: Resealed ghost of red blood cells (RBCs) from advanced cancer patients includes proteins with antigenicities common to an anemia-inducing substance that we separated from plasma of patients with advanced malignant neoplasms. Although cation influx in vitro in RBCs from a cancer patient is larger than that from a normal healthy volunteer, an antibody against anemia-inducing substance inhibited the in vitro cation influx in RBCs from the cancer patient. Activation of the cation influx with N-ethylmaleimide after reaction with the antibody reversed the effect to create a greater cation influx in RBCs from the patient, as compared with that from the healthy volunteer.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 5454-8585, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D000740:Anemia / Q000139:chemically induced; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D001798:Blood Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D002412:Cations / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005033:Ethylmaleimide / Q000494:pharmacology; D005260:Female; D006801:Humans; D008970:Molecular Weight; D009369:Neoplasms / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood; D012413:Rubidium / Q000378:metabolism
chemical_list: D000906:Antibodies; D001798:Blood Proteins; D002412:Cations; D012413:Rubidium; D005033:Ethylmaleimide