Live stripping of clathrin-coated vesicles.
Vesicle budding requires recruitment of a coat, which must then be removed to allow fusion with the target compartment. In vitro assays have implicated Hsc70 and auxilin family members as key players in clathrin-coated vesicle uncoating. New in vivo studies now show that this is indeed the case and reveal additional functions of the Hsc70/auxilin complex.
Cremona
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Università Vita-Salute San Raffaele, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milano, Italy.
D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D001693:Biological Transport, Active; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D002966:Clathrin / Q000235:genetics / Q000378:metabolism; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D004705:Endocytosis; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*
D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; D002966:Clathrin; D050883:HSC70 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins