[Peripheral blood lymphocyte subpopulations of postmenopausal women with hormone replacement therapy].
The effect of hormone replacement therapy on cellular immunity of postmenopausal women was studied by flow cytometry (FACS). Lymphocyte subsets in peripheral blood before and after hormonal replacement therapy (HRT) were measured. After 6 months of HRT with the sequential combined drug Klimonorm(R) (2 mg estradiol valerate and 0,15 mg levonorgestrel) the cytotoxic T-cells (CD8) were reduced and the CD4/CD8 ratio was increased significantly (p < 0,05).
Höll
M
M
Universitätsfrauenklinik der Medizinischen Fakultät der Otto-von-Guericke-Universität Magdeburg und Gynäkologische Belegabteilung der Klinik des Westens Magdeburg.
Donat
H
H
Weise
W
W
D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D016022:Case-Control Studies; D003279:Contraceptives, Oral, Sequential / Q000276:immunology* / Q000627:therapeutic use; D004338:Drug Combinations; D004958:Estradiol / Q000031:analogs & derivatives* / Q000276:immunology* / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy / Q000009:adverse effects* / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006684:HLA-DR Antigens / Q000187:drug effects; D006801:Humans; D016912:Levonorgestrel / Q000276:immunology* / Q000627:therapeutic use; D016131:Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D008875:Middle Aged; D017698:Postmenopause / Q000276:immunology*; D011446:Prospective Studies
D003279:Contraceptives, Oral, Sequential; D004338:Drug Combinations; D006684:HLA-DR Antigens; C097275:klimonorm; D004958:Estradiol; D016912:Levonorgestrel