title: Training status influences T-cell responses in women following acute resistance exercise.
abstract: The purpose of this investigation was to examine white blood cell counts (WBC), immunoglobulin (IgA, IgG, IgM) levels, and T-cell proliferation following acute resistance training in 9 untrained (UT) and 6 trained (TR) women. Resistance training on 7 Universal machines at the subject's 10 repetition maximum (IORM) was performed at 89 +/- 5% for UT and 88 +/- 3% for TR. Blood was analyzed for WBCs and Ig levels pre-exercise, immediately postexercise, and 1.5, 3, and 24 hours postexercise. T-cell proliferation was determined pre-exercise and 3 hours postexercise through response to phytohemagglutanin (PHA). WBCs were significantly elevated in the UT subjects 1.5 and 3 hours postexercise compared with pre- and immediately postexercise; no differences (p < 0.05) were observed in TR subjects. No significant differences were found for Ig levels either between or within groups, although there was a trend for decreased IgG following exercise. T-cell proliferation was significantly decreased in the UT at 3 hours postexercise (0.27 +/- 0.06 units) compared with pre-exercise (0.41 +/- 0.06 units), whereas the proliferative response in TR was not significantly different from pre-exercise (0.48 +/- 0.04 units) to 3 hours postexercise (0.34 +/- 0.06 units). These data indicate that UT subjects experience an increase in WBC counts and a decrease in T-cell proliferative ability after acute resistance training, whereas TR subjects experience no significant change in these parameters.
authors.affiliation: Department of Health, Sport, and Exercise Science, University of Kansas, Lawrence 66045, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Potteiger
authors.forename: M A
authors.initials: MA
authors.lastname: Chan
authors.forename: G G
authors.initials: GG
authors.lastname: Haff
authors.forename: S
authors.initials: S
authors.lastname: Mathew
authors.forename: C A
authors.initials: CA
authors.lastname: Schroeder
authors.forename: M D
authors.initials: MD
authors.lastname: Haub
authors.forename: C
authors.initials: C
authors.lastname: Chirathaworn
authors.forename: S A
authors.initials: SA
authors.lastname: Tibbetts
authors.forename: J
authors.initials: J
authors.lastname: Mcdonald
authors.forename: O
authors.initials: O
authors.lastname: Omoike
authors.forename: S H
authors.initials: SH
authors.lastname: Benedict
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007773:Lactates / Q000097:blood; D007958:Leukocyte Count; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007773:Lactates