Synthesis and antiproliferative activity of some thiazolylbenzimidazole-4,7-diones.
Some thiazolylbenzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Compounds 2d and 2e show a very good activity on K562 cells, whereas compounds 2a and 2b are active on SW620 cells. The importance of the methoxy group on the quinone moiety is confirmed and the function at 4-position of the thiazole ring plays a determining role for the activity.
Garuti
L
L
Department of Pharmaceutical Science, University of Bologna, via Belmeloro 6, I-40126, Bologna, Italy. lauga@alma.unibo.it
Roberti
M
M
Pession
A
A
Leoncini
E
E
Hrelia
S
S
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D006801:Humans; D013844:Thiazoles / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001562:Benzimidazoles; D013844:Thiazoles