Nucleotide sequence of exons 2 and 3 of the novel HLA-Cw*12032 allele.
A novel HLA-C nucleotide sequence was discovered in an individual of Pacific Island, Tongan ethnicity using sequencing based typing. The sequence was given an official allele designation HLA-Cw*12032 by the WHO Nomenclature Committee for Factors of the HLA System. The novel sequence has 2 bp substitutions compared to the HLA-Cw*1203 at codon 134 "T" to "C" and codon 135 "C" to "G". However, when converted to amino acid sequences HLA-Cw*1203 and HLA-Cw*12032 are identical and would not have direct clinical implications.
Velickovic
Z M
ZM
Department of Pathology and Molecular Medicine, Wellington School of Medicine, Wellington, New Zealand. zlatibor@wnmeds.ac.nz
Carter
J M
JM
D000483:Alleles; D001483:Base Sequence; D005091:Exons / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
D015236:HLA-C Antigens; C110748:HLA-C*12 antigen; C446263:HLA-C*12:03 antigen