title: Meal replacements in weight intervention.
abstract: OBJECTIVE
  To evaluate the effectiveness of meal replacements (MRs) in weight loss interventions in premenopausal women.
  
  
  METHODS
  Overweight premenopausal women (n = 113; body mass index: 25 to 35 kg/m(2); 30 to 50 years old) were randomized into three interventions: group A, a dietitian-led intervention; group B, a dietitian-led intervention incorporating MRs; and group C, a clinical office-based intervention incorporating MRs. In year 1, groups A and B attended 26 group sessions, whereas group C received the same educational materials during 26 10-minute office visits with a physician-nurse team. In year 2, participants attended monthly group seminars and drop-in visits with a dietitian.
  
  
  RESULTS
  For the 74 subjects completing year 1, weight loss in the office-based group C was as effective as the traditional dietitian-led group A (4.3 +/- 6.5% vs. 4.1 +/- 6.4%), while group B maintained a significantly greater weight loss (9.1 +/- 8.9%; p < 0.02; mean +/- SD). For the 43 subjects completing year 2, group B showed significant differences in the percentage of weight loss (-8.5 +/- 7.0%) compared with group A (-1.5 +/- 5.0%) and group C (-3.0 +/- 7.0%; p < 0.001).
  
  
  CONCLUSIONS
  Study results showed that a traditional weight loss intervention incorporating MRs was effective as a weight loss tool in the medical office practice and in the dietitian-led group setting.
authors.affiliation: Nutrition Education and Research Program, University of Nevada School of Medicine, Reno, 89557, USA. jashley@unr.nevada.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Ashley
authors.forename: S T
authors.initials: ST
authors.lastname: St  Jeor
authors.forename: S
authors.initials: S
authors.lastname: Perumean-Chaney
authors.forename: J
authors.initials: J
authors.lastname: Schrage
authors.forename: V
authors.initials: V
authors.lastname: Bovee
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D004032:Diet; D004046:Dietetics; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008019:Life Style; D018977:Micronutrients / Q000008:administration & dosage; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy*; D010353:Patient Education as Topic; D017697:Premenopause; D011320:Primary Health Care; D012307:Risk Factors; D015431:Weight Loss
chemical_list: D018977:Micronutrients