Clinical applications of bone graft substitutes in spine surgery: consideration of mineralized and demineralized preparations and growth factor supplementation.
Bone graft substitutes may be broadly classified as mineralized and demineralized preparations. This article reviews the basic science and biology underlying each preparation. A review of the clinical and experimental applications of each preparation follows. The text concludes with a review of growth factors as biological supplements.
Berven
S
S
Department of Orthopedic Surgery, UC San Francisco, CA 94143, USA. bervens@orthosurg.ucsf.edu
Tay
B K
BK
Kleinstueck
F S
FS
Bradford
D S
DS
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018775:Bone Demineralization Technique; D001857:Bone Matrix / Q000637:transplantation*; D002516:Ceramics; D006133:Growth Substances / Q000627:therapeutic use*; D006801:Humans; D019736:Prostheses and Implants; D013123:Spinal Fusion / Q000379:methods*; D013131:Spine / Q000601:surgery*; D014184:Transplantation, Homologous
D001672:Biocompatible Materials; D006133:Growth Substances