Calcium signal transmission between ryanodine receptors and mitochondria in cardiac muscle.
Ryanodine receptor (RyR) mediated Ca(2)+ signals play a central role in excitation-contraction coupling in cardiac muscle. To support the rhythmic contractile activity there is a need for continuous tuning of cellular oxidative energy generation in the mitochondria to the actual work-load. Evidence has emerged that RyR-mediated cytosolic Ca(2)+ signals are efficiently transmitted to the mitochondria, providing a means for coupling cardiac muscle excitation to oxidative energy production, through activation of Ca(2)+ sensitive mitochondrial dehydrogenases. Recent data suggest that the Ca(2)+ signal transmission between RyR and mitochondria is dependent on local Ca(2)+ interactions between subdomains of sarcoplasmic reticulum (SR) and mitochondria. Here we give a short overview of the determinants and spatio-temporal organization of Ca(2)+ signal transmission between SR and mitochondria.
Csordás
G
G
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Thomas
A P
AP
Hajnóczky
G
G
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D019837:Ryanodine Receptor Calcium Release Channel