title: Free radical oxidation and activity of enzymes catalyzing biotransformation of xenobiotics in the liver of rats with experimental acute pancreatitis.
abstract: The development of experimental acute pancreatitis in rats was accompanied by intensification of lipid peroxidation, activation of superoxide dismutase and glutathione reductase, inhibition of glutathione transferase, and deceleration of aniline N-hydroxylation by cytochrome P-450 in the liver. Antioxidants inhibited lipid peroxidation and antioxidant enzymes, but did not prevent inhibition of detoxifying enzymes.
authors.affiliation: Department of Surgery, Samara Military Medical Institute.
authors.forename: V I
authors.initials: VI
authors.lastname: Shabanov
authors.forename: N N
authors.initials: NN
authors.lastname: Sarbaeva
authors.forename: M N
authors.initials: MN
authors.lastname: Milyakova
authors.forename: V P
authors.initials: VP
authors.lastname: Detyuchenko
mesh_terms: D000208:Acute Disease; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D002374:Catalase / Q000378:metabolism; D002384:Catalysis; D004789:Enzyme Activation; D005609:Free Radicals / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D010084:Oxidation-Reduction; D010195:Pancreatitis / Q000201:enzymology* / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D015262:Xenobiotics; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D008049:Lipase; D000681:Amylases