Heterodimerization of G-protein-coupled receptors in the CNS.
Over the last year the combinations of G-protein-coupled receptors that are known to form heterodimeric complexes has rapidly increased. For example, dopamine receptors can dimerize with both somatostatin and adenosine receptors. These studies have been aided by improved technologies to monitor protein/protein interactions in living cells. Crosstalk at the level of the receptors might explain some of the known physiological interactions of these neurotransmitter systems and also provide new approaches for therapeutic intervention.
Marshall
F H
FH
Molecular Pharmacology Department, GlaxoWellcome Research and Development, Stevenage, Hertfordshire, UK. fhm27375@glaxowellcome.co.uk
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism*
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins