Design of a trial evaluating myocardial cell protection with cariporide, an inhibitor of the transmembrane sodium-hydrogen exchanger: the Guard During Ischemia Against Necrosis (GUARDIAN) trial.
Inhibition of the sodium-hydrogen exchanger (NHE) is a powerful experimental tool to inhibit sodium and calcium accumulation within the ischemic myocyte and halt progression of cell ischemia to cell necrosis. This paper describes the protocol and rationale of a first large-scale clinical trial designed to evaluate the safety and efficacy of cariporide, a novel specific and potent inhibitor of the exchanger.
Theroux
Pierre
P
University of Montreal and Montreal Heart Institute, Montreal, Canada. theroux@ICUM.Umontreal.CA
Chaitman
Bernard R
BR
Erhardt
Leif
L
Jessel
Andreas
A
Meinertz
Thomas
T
Nickel
Wolf-Ulrich
WU
Schroeder
John S
JS
Tognoni
Gianni
G
White
Harvey
H
Willerson
James T
JT