title: Comparison of transthoracic Doppler echocardiography and natriuretic peptides in predicting mean pulmonary capillary wedge pressure in patients with chronic atrial fibrillation.
abstract: The purpose of this study was to assess whether transthoracic Doppler echocardiography and serum natriuretic peptide levels could predict mean pulmonary capillary wedge pressure (PCWP) in patients with chronic atrial fibrillation. We examined mitral flow velocity and pulmonary venous flow (PVF) velocity patterns in 32 patients with chronic atrial fibrillation. Plasma A-type and B-type natriuretic peptide (ANP, BNP, respectively) levels in the peripheral vein were measured. Significant correlations were observed between mean PCWP and the following: peak velocity (r = 0.51) and deceleration time (r = -0.65) of the mitral flow; peak velocity (r = 0.64) and deceleration time (r = -0.80) of the PVF; BNP (r = 0.60); and ANP (r = 0.36). Stepwise multiple linear regression analysis selected PVF deceleration time and mitral flow deceleration time as independent predictors of PCWP. A cutoff value of PVF deceleration time of < or =150 ms and a mitral flow deceleration time of < or =100 ms predicted a mean PCWP of > or =18 mm Hg, with a sensitivity of 100% and 80% and a specificity of 96% and 85%, respectively. In conclusion, PVF deceleration time and mitral flow deceleration time obtained from transthoracic Doppler echocardiography are more accurate predictors of mean PCWP than values obtained with natriuretic peptides in patients with chronic atrial fibrillation.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima City, 890-8520, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsukida
authors.forename: A
authors.initials: A
authors.lastname: Kisanuki
authors.forename: K
authors.initials: K
authors.lastname: Toyonaga
authors.forename: T
authors.initials: T
authors.lastname: Murayama
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: T
authors.initials: T
authors.lastname: Kumanohoso
authors.forename: S
authors.initials: S
authors.lastname: Yoshifuku
authors.forename: M
authors.initials: M
authors.lastname: Saigo
authors.forename: S
authors.initials: S
authors.lastname: Abe
authors.forename: S
authors.initials: S
authors.lastname: Hamasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Otsuji
authors.forename: S
authors.initials: S
authors.lastname: Minagoe
authors.forename: C
authors.initials: C
authors.lastname: Tei
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002908:Chronic Disease; D015150:Echocardiography, Doppler / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging*; D011664:Pulmonary Valve / Q000000981:diagnostic imaging*; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D012039:Regional Blood Flow; D012044:Regression Analysis
chemical_list: D009320:Atrial Natriuretic Factor