Glycoside in schizophrenic patients sera affects behavior of mouse forced swimming.
We found a glycoside in sera of schizophrenic patients. This glycoside increased climbing of mouse forced swimming and the climbing was decreased by dopamine D1 receptor antagonist SCH-23390 with a dose dependent manner. This glycoside had much reactivity of GalNAc alpha1-3GalNAc, but not that of polymannoses nor that of Gal beta1-3GlcNAc alpha1-serine or threonine. This strongly suggests that the glycoside is an isolated O-glycoside, but not N-glycoside nor O-glycoside having core 1 or 2. The present findings suggest that schizophrenic patients have the special glycoside affecting the D1 receptor activity in their serum.
Masuda
Y
Y
Department of Neuropsychiatry, Akita University School of Medicine, Japan.
Ohnuma
S
S
Sugawara
J
J
Sugiyama
T
T
D000328:Adult; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D006027:Glycosides / Q000097:blood* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000097:blood*; D012565:Schizophrenic Psychology; D013550:Swimming
D006027:Glycosides; D017447:Receptors, Dopamine D1