Oral administration of soybean lecithin transphosphatidylated phosphatidylserine improves memory impairment in aged rats.
Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was prepared from soybean lecithin and L-serine by a transphosphatidylation reaction, and its effect on age-related memory impairment was evaluated in rats by the Morris water maze test. Continuous oral administration of SB-tPS (60 mg x kg(-1) x d(-1) for 60 d) to male aged rats (24-25 mo) significantly improved performance in the water maze escape test (P < 0.01 vs. control aged rats) similar to bovine brain cortex-derived phosphatidylserine, which restores cognitive function in patients with senile dementia. SB-tPS also increased acetylcholine release and the Na(+), K(+)-ATPase activity of the synaptosomes prepared from these aged rats to the level in young rats. The nootropic actions of SB-tPS in the present study can be partly explained by the changes in these biochemical activities.
Suzuki
S
S
Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 186-8650, Japan.
Yamatoya
H
H
Sakai
M
M
Kataoka
A
A
Furushiro
M
M
Kudo
S
S
D000109:Acetylcholine / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy*; D010718:Phosphatidylserines / Q000008:administration & dosage / Q000627:therapeutic use*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013025:Glycine max
D010718:Phosphatidylserines; D010743:Phospholipids; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase; D000109:Acetylcholine