title: Contents and uptake rates of Mn, Fe, Co, Zn, and Se in Se-deficient rat liver cell fractions.
abstract: The contents of manganese (Mn), iron (Fe), cobalt (Co), zinc (Zn), and selenium (Se) in nuclear (NU), mitochondrial (MT), microsomal (MC), and cytosolic (CS) fractions of liver homogenates of normal and selenium-deficient (SeD) rats were determined by instrumental neutron activation analysis (INAA). The uptake rates of these elements in the liver cell fractions of both groups of rats were determined by multitracer analysis (MTA). The results indicated that Se-deficiency caused a significant increase in the content of Fe in the MC fractions. The MTA showed that the uptake rate of Fe was highest in the MC fraction, and that the uptake rate in the fraction was similar between the SeD and normal rats.
authors.affiliation: Department of Physical Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan. knmatsu@ac.shoyaku.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Inagaki
authors.forename: R
authors.initials: R
authors.lastname: Hirunuma
authors.forename: S
authors.initials: S
authors.lastname: Enomoto
authors.forename: K
authors.initials: K
authors.lastname: Endo
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001693:Biological Transport, Active; D003300:Copper / Q000378:metabolism; D004032:Diet; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008345:Manganese / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D009501:Neutron Activation Analysis; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D008670:Metals; D017392:Thiobarbituric Acid Reactive Substances; D008345:Manganese; D003300:Copper; D007501:Iron; D005979:Glutathione Peroxidase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D012643:Selenium; D015032:Zinc