Modification of membrane-toxic effect of Nd-YAG laser by preliminary induction of cytochrome P-450 in bone marrow cells.
The cytotoxic effects of Nd-YAG laser with a wavelength of 533 nm were studied in mouse bone marrow cells in vitro. Laser exposure caused blebbing of bone marrow cell plasma membrane. Preliminary induction of cytochrome P-450 with 3-methylcholanthrene modified the cytotoxic effect of Nd-YAG laser.
Stavitskaya
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EY
Department of Pathophysiology with a Course of Functional Diagnosis, Krasnoyarsk State Medical Academy. onmpi@krsk.infotel.ru
Egorova
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AB
Salmin
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Zobova
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Provorov
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AS
D000818:Animals; D001854:Bone Marrow Cells / Q000201:enzymology / Q000528:radiation effects* / Q000648:ultrastructure; D002462:Cell Membrane / Q000528:radiation effects / Q000648:ultrastructure; D002478:Cells, Cultured; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004334:Drug Administration Schedule; D004790:Enzyme Induction; D007274:Injections, Intraperitoneal; D007834:Lasers / Q000009:adverse effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008748:Methylcholanthrene / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D011837:Radiation-Protective Agents; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System