Urothelial malignant disease and Chinese herbal nephropathy.
We have previously reported occurrence of a specific type of nephropathy due to ingestion of Chinese herbs (Chinese herbal nephropathy [CHN]) in two patients in the UK. These cases highlighted the role of aristolochic acid in causing this nephropathy, which was first described in a Belgian cohort. We now report development of invasive transitional cell carcinoma of the urinary tract associated with the presence of aristolochic acid-DNA adducts in one of these patients. This work clearly shows the carcinogenic potential of aristolochic acid in this new type of nephropathy.
Lord
G M
GM
Cook
T
T
Arlt
V M
VM
Schmeiser
H H
HH
Williams
G
G
Pusey
C D
CD
D034341:Aristolochic Acids; D002273:Carcinogens / Q000009:adverse effects*; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D008875:Middle Aged; D010616:Phenanthrenes / Q000009:adverse effects*; D014516:Ureteral Neoplasms / Q000139:chemically induced* / Q000473:pathology
D034341:Aristolochic Acids; D002273:Carcinogens; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; C000228:aristolochic acid I