Changes in serum cardiac troponin I levels after percutaneous transluminal coronary angioplasty.
OBJECTIVE
To evaluate the possible effect of percutaneous transluminal coronary (PTCA) on myocardium.


METHODS
Serum cTnl and CK-MB were measured in 60 patients with coronary artery disease (CAD) who underwent PTCA before and at the 6th, 12th, 24th, 48th and 72nd hour after the interventional procedure respectively.


RESULTS
The serum cTnl levels began to increase at 6 hours (9.65 +/- 6.27 micrograms/L) in 18 patients, reached the peak levels during 12-24 hours (20.43 +/- 11.28 micrograms/L, 18.52 +/- 9.52 micrograms/L), and returned to normal range till 48-72 hours (7.35 +/- 7.62 micrograms/L, 5.51 +/- 3.13 micrograms/L) after PTCA. The serum cTnl and CK-MB levels were kept normal range pre- and post-PTCA in 30 cases. The levels of cTnl in 12 cases were over baseline either before or after the procedure, while for CK-MB, only in 3 cases were over normal range after PTCA. Compared with normal cTnl group, elevated cTnl levels were related to total inflation times and dilated times (P < 0.05).


CONCLUSIONS
PTCA may cause some minor damage in myocardium, serum cTnl level was more sensitive and specific for monitoring myocardial injury.
Yang
Z
Z
Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jia
Y
Y
Zhang
J
J
Cao
K
K
Zhang
F
F
Ma
G
G
Ma
W
W
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000601:surgery; D000789:Angina, Unstable / Q000097:blood / Q000601:surgery; D015906:Angioplasty, Balloon, Coronary; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000601:surgery; D019210:Troponin I / Q000097:blood*
D007527:Isoenzymes; D019210:Troponin I; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form