title: Outpatient inhaled nitric oxide in a patient with idiopathic pulmonary fibrosis: a bridge to lung transplantation.
abstract: Inhaled nitric oxide (INO) has been shown to improve oxygenation and decrease intrapulmonary shunt and pulmonary hypertension in various lung diseases. In this study we report a patient with end-stage idiopathic pulmonary fibrosis and pulmonary hypertension who received INO after coronary artery bypass surgery, with significant improvement in arterial oxygenation and pulmonary arterial pressure. Using a pulsing delivery system, the patient continued to receive outpatient INO for 30 months while waiting for lung transplantation. Exercise study and two-dimensional echocardiogram, after 3 months of inhaled NO, demonstrated continued benefits of INO for improvement of arterial oxygenation, pulmonary arterial pressure and exercise tolerance.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Diego School of Medicine, San Diego, California 92103-8373, USA. gyung@ucsd.edu
authors.forename: G L
authors.initials: GL
authors.lastname: Yung
authors.forename: J M
authors.initials: JM
authors.lastname: Kriett
authors.forename: S W
authors.initials: SW
authors.lastname: Jamieson
authors.forename: F W
authors.initials: FW
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Newhart
authors.forename: K
authors.initials: K
authors.lastname: Kinninger
authors.forename: R N
authors.initials: RN
authors.lastname: Channick
mesh_terms: D000280:Administration, Inhalation; D000553:Ambulatory Care; D001026:Coronary Artery Bypass; D006801:Humans; D006976:Hypertension, Pulmonary / Q000628:therapy; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000008:administration & dosage*; D011183:Postoperative Complications; D011658:Pulmonary Fibrosis / Q000628:therapy*
chemical_list: D009569:Nitric Oxide