Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.
The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throughout the world has prompted a search for new, safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(alpha-D-arabinofuranosyl)-alpha-D-arabinofuranoside analogues were synthesized and evaluated as inhibitors for M. tuberculosis and Mycobacterium avium. A cell free assay system has been used for the evaluation of these disaccharides as substrates for mycobacterial arabinosyltransferase activity.
Pathak
A K
AK
Department of Organic Chemistry, Southern Research Institute, PO Box 55305, Birmingham, AL 35255, USA.
Pathak
V
V
Maddry
J A
JA
Suling
W J
WJ
Gurcha
S S
SS
Besra
G S
GS
Reynolds
R C
RC
D000995:Antitubercular Agents / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D002236:Carbohydrate Conformation; D004187:Disaccharides / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D009162:Mycobacterium avium / Q000187:drug effects / Q000201:enzymology; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology*; D010430:Pentosyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D004187:Disaccharides; D010430:Pentosyltransferases; C101967:arabinosyltransferase