[High prevalence of islet cell and glutamate decarboxylase antibodies in healthy young adults born with low birth weight].
Low birth weight is an independent risk factor for several chronic adult diseases. The authors determined the prevalence of islet cell cytoplasmatic antibody (ICA), glutamic acid decarboxylase antibody (GADA) and tyrosine phosphatase antibody (IA2) in 41 women and 34 men born with a birth weight under 2500 grams. ICA and/or GADA positivity was detected in 32% of the subjects tested. Both antibodies were present in 11% of the subjects. IA2 positivity was not found in any of the enrolled subjects. The cause of the high prevalence of autoantibodies is still unclear. Further studies are needed to elucidate whether this phenomenon might have a role in the development of metabolic disturbances in late adulthood.
Luczay
A
A
Altalános Orvostudományi Kar, I. Gyermekklinika, Semmelweis Egyetem, Budapest. andrea@gyerl.sote.hu
Vásárhelyi
B
B
Madácsy
L
L
Pánczél
P
P
Tulassay
T
T
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D015995:Prevalence; D017027:Protein Tyrosine Phosphatases / Q000276:immunology*; D012016:Reference Values
D001323:Autoantibodies; C024211:islet cell antibody; D017027:Protein Tyrosine Phosphatases; D005968:Glutamate Decarboxylase