Successful bone marrow transplantation for adult T-cell leukemia from a donor with oligoclonal proliferation of T-cells infected with human T-cell lymphotropic virus.
We describe a patient who underwent successful BMT from her sibling for the treatment of adult T-cell leukemia/lymphoma. Pre-transplant examination of the donor revealed oligoclonal integration of HTLV-I proviruses within the germ line, and our concern was that clinical sequelae of HLTV-I infection might become evident in the setting of post-transplant immunosuppression. However, the patient has been in complete remission for 14 months after transplantation, and no clonality of HTLV-I provirus was detected in the peripheral blood cells using southern blotting analysis. Our experience supports the possibility of transplantation from HTLV-I positive donors.
Kishi
Y
Y
Department of Hematology, Toranomon Hospital, Tokyo, Japan.
Kami
M
M
Oki
Y
Y
Hamaki
T
T
Kanda
Y
Y
Machida
U
U
Miyakoshi
S
S
Ueyama
J
J
Morinaga
S
S
Muto
Y
Y
D016026:Bone Marrow Transplantation; D002455:Cell Division; D002999:Clone Cells / Q000473:pathology / Q000821:virology; D005260:Female; D015490:HTLV-I Infections / Q000635:transmission; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000628:therapy*; D008875:Middle Aged; D012074:Remission Induction; D013601:T-Lymphocytes / Q000473:pathology / Q000821:virology; D014019:Tissue Donors