title: Respiratory symptoms and lung function in bauxite miners.
abstract: OBJECTIVE
  To determine whether cumulative bauxite exposure is associated with respiratory symptoms or changes in lung function in a group of bauxite miners.
  
  
  METHODS
  Current employees at three bauxite mines in Australia were invited to participate in a survey comprising: questionnaire on demographic details, respiratory symptoms, and work history; skin prick tests for four common aeroallergens; and spirometry. A task exposure matrix was constructed for bauxite exposure in all tasks in all jobs based on monitoring data. Data were examined for associations between cumulative bauxite exposure, and respiratory symptoms and lung function, by regression analyses.
  
  
  RESULTS
  The participation rate was 86%. Self-reported work-related respiratory symptoms were reported by relatively few subjects (1.5%-11.8%). After adjustment for age and smoking no significant differences in the prevalence of respiratory symptoms were identified between subjects, in the quartiles of cumulative bauxite exposure distribution. The forced expiratory volume in I s (FEV1) of the exposed group was found to be significantly lower than that for the unexposed group. After adjustment for age, height, and smoking there were no statistically significant differences between quartiles in FEVI, forced vital capacity (FVC) and FEVl/FVC ratio.
  
  
  CONCLUSIONS
  These data provide little evidence of a serious adverse effect on respiratory health associated with exposure to bauxite in an open-cut bauxite mine in present day conditions.
authors.affiliation: Institute of Occupational Health, University of Birmingham. Birmingham, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Beach
authors.forename: N H
authors.initials: NH
authors.lastname: de Klerk
authors.forename: L
authors.initials: L
authors.lastname: Fritschi
authors.forename: M R
authors.initials: MR
authors.lastname: Sim
authors.forename: A W
authors.initials: AW
authors.lastname: Musk
authors.forename: G
authors.initials: G
authors.lastname: Benke
authors.forename: M J
authors.initials: MJ
authors.lastname: Abramson
authors.forename: J J
authors.initials: JJ
authors.lastname: McNeil
mesh_terms: D000328:Adult; D000537:Aluminum Oxide; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008906:Mining; D016273:Occupational Exposure; D015656:Respiratory Mechanics; D014797:Vital Capacity
chemical_list: D000537:Aluminum Oxide