Prevalence and clinical manifestations of disseminated Mycobacterium avium complex infection in South Africans with acquired immunodeficiency syndrome.
In a sample of 100 hospitalized human immunodeficiency virus-seropositive black South African patients with CD4 cell counts of <100 cells/mm(3), the point prevalence of disseminated Mycobacterium avium complex infection was 10%, in contrast with other African studies that report that the infection is uncommon. The point prevalence of Mycobacterium tuberculosis was 54%. The clinical and laboratory features of these patients were largely unhelpful in detecting M. avium complex; the BACTEC blood culture (Becton Dickinson) was the only reliable method.
Pettipher
C A
CA
Department of Medicine, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South Africa. cpetti@netactive.co.za
Karstaedt
A S
AS
Hopley
M
M
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology / Q000635:transmission; D015995:Prevalence; D011446:Prospective Studies; D013019:South Africa / Q000453:epidemiology