title: A new HLA-Cw allele (Cw*1510), identified in a French Caucasian individual.
abstract: A novel HLA-Cw*15 allele, Cw*1510, found in a French Caucasian bone marrow recipient is described. Nucleotide sequence of the new variant is identical to the common Cw*15021 DNA sequences except nucleotides at positions 32 and 61 of exon 2. While the first difference is silent, the second cause substitution of an Histidine by an Arginine at amino acid position 21 of the alpha1 heavy chain domain.
authors.affiliation: Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint Louis AP-HP, IUH université Paris VII and INSERM U396, Paris, France. tamouza@histo.chu-stlouis.fr
authors.forename: R
authors.initials: R
authors.lastname: Tamouza
authors.forename: V
authors.initials: V
authors.lastname: Schaeffer
authors.forename: F
authors.initials: F
authors.lastname: Marzais
authors.forename: J C
authors.initials: JC
authors.lastname: Poirier
authors.forename: C
authors.initials: C
authors.lastname: Fortier
authors.forename: R
authors.initials: R
authors.lastname: Ramasawmy
authors.forename: R
authors.initials: R
authors.lastname: Sghiri
authors.forename: R
authors.initials: R
authors.lastname: Krishnamoorthy
authors.forename: A
authors.initials: A
authors.lastname: Toubert
authors.forename: D
authors.initials: D
authors.lastname: Charron
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence; D005091:Exons; D005602:France; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D044465:White People / Q000235:genetics*
chemical_list: D015236:HLA-C Antigens; C446264:HLA-C*15 antigen