[Immunotropic activity of panaxans--bioglycans isolated from ginseng].
Immunomodulating activity of panaxanes--polysaccharides isolated from the roots and culture of Panax ginseng was studied. Effects of both preparations were analogous. Profilaxy use of panaxanes provided increased resistance to coli-sepsis in mice, increased neutrophiles and macrophages phagocytosis, stimulated humoral and cell immune factors and induced important regulating cytokins--interferone gamma and tumor necrosis factor.
Smolina
T P
TP
Research Institute of Epidemiology and Microbiology, Siberian Branch of the Russian Academy of Medical Sciences, Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok.
Solov'eva
T F
TF
Besednova
N N
NN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology; D002478:Cells, Cultured; D004926:Escherichia coli; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D007371:Interferon-gamma / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000276:immunology; D005894:Panax; D010587:Phagocytosis; D028321:Plant Preparations / Q000494:pharmacology; D018517:Plant Roots; D011134:Polysaccharides / Q000494:pharmacology*; D018805:Sepsis / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015011:Yersinia pseudotuberculosis / Q000276:immunology
D000276:Adjuvants, Immunologic; D028321:Plant Preparations; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; C044185:panaxans