A 23Na NMR study of the effect of D(+) and L(-) arabitol on NaDNA in aqueous solution.
The 23Na NMR quadrupolar relaxation in NaDNA aqueous solutions has been investigated in the presence of D(+) and L(-) arabitol. Quite different results were produced by the enantiomers, i.e. the addition of D(+) arabitol produced a small increase of the 23Na NMR relaxation rates, while in the presence of L(-) arabitol a significant decrease was observed. These findings were analysed and discussed in terms of an effective interaction of L(-) arabitol with DNA.
Marincola
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FC
Dipartimento di Scienze Chimiche, Università di Cagliari, Cittadella Universitaria di Monserrato, S.S. 554 09042 (CA), Monserrato, Italy.
Casu
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M
Saba
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G
Lai
A
A
del Vecchio
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P
Barone
G
G
D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D009682:Magnetic Resonance Spectroscopy; D011485:Protein Binding; D012975:Sodium Isotopes; D013402:Sugar Alcohols / Q000737:chemistry*; D013950:Thymus Gland / Q000378:metabolism; D014867:Water / Q000737:chemistry*
D012975:Sodium Isotopes; D013402:Sugar Alcohols; D014867:Water; D004247:DNA; C014999:arabitol