Intricacies in ATP-dependent clamp loading: variations across replication systems.
DNA replication requires the coordinated effort of many proteins to create a highly processive biomachine able to replicate entire genomes in a single process. The clamp proteins confer on replisomes this property of processivity but in turn require clamp loaders for their functional assembly onto DNA. A more detailed view of the mechanisms for holoenzyme assembly in replication systems has been obtained from the advent of novel solution experiments and the appearance of low- and high-resolution structures for the clamp loaders.
Trakselis
M A
MA
Department of Chemistry, 414 Wartik Laboratory, Pennsylvania State University, University Park, PA 16802, USA.
Benkovic
S J
SJ
D000255:Adenosine Triphosphate / Q000378:metabolism*; D017122:Bacteriophage T4 / Q000201:enzymology; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism* / Q000648:ultrastructure*; D004926:Escherichia coli / Q000201:enzymology; D008958:Models, Molecular; D020409:Molecular Motor Proteins
D020409:Molecular Motor Proteins; D000255:Adenosine Triphosphate; D004259:DNA-Directed DNA Polymerase