[Screening of beta zero-thalassemia in cord blood from 2,423 newborns in Xilin county of Guangxi].
OBJECTIVE
To investigate the incidence of beta zero-thalassemia in newborns in Xilin county of Guangxi and identify the common type of the gene mutation.


METHODS
Cord blood samples from successive 2,423 newborns were screened for beta zero-thalassemia by PAGE, and the gene mutation was assayed by PCR and dot blot hybridization.


RESULTS
Seven cases (0.29%) of beta zero-thalassemia were revealed in the 2,423 newborns. The gene mutation types were as follows: three cases of CD17/CD17, two of CD17/CD41-42, one of CD41-42/CD41-42 and one of CD17/IVS-I-1.


CONCLUSIONS
These data might be of help to prenatal diagnosis of beta zero-thalassemia in Guixi district.
Pan
H
H
Department of Pediatrics, Affiliated Hospital of Youjiang Nation Medical College, Guangxi Baise 533000.
Li
Q
Q
Zhao
G
G
D002681:China / Q000453:epidemiology; D005260:Female; D005312:Fetal Blood; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008403:Mass Screening; D009154:Mutation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics*; D017086:beta-Thalassemia / Q000453:epidemiology / Q000517:prevention & control*
D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex