Circulating fetal RNA in maternal plasma.
The discovery of cell-free nucleic acids in plasma has opened up new possibilities for noninvasive clinical diagnosis. We demonstrate the presence of cell-free fetal RNA in maternal plasma, indicating that plasma fetal RNA might be used as a marker for noninvasive prenatal diagnosis.
Poon
L L
LL
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR.
Leung
T N
TN
Lau
T K
TK
Lo
Y M
YM
D015415:Biomarkers; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012313:RNA / Q000097:blood*
D015415:Biomarkers; D012313:RNA