[Antineoplastic activity of 5-fluorouracil upon transdermal adminstration using "Coletex" napkins].
The paper presents data on the effect of 5-fluorouracil (5-FU)-impregnated Coletex napkins on rats and mice with transplantable subcutaneous tumors of different histological patterns: Pliss lymphosarcoma, Walker carcinosarcoma and Ehrlich carcinoma. Since the napkins showed antitumor activity it is suggested that they might find application in treating a number of oncological pathologies, particularly, skin lesions and ulcerated and necrotized tumors.
Vartanian
L P
LP
Central Research Institute of Roentgeno-Radiology, Ministry of Health of the RF, St. Petersburg.
Oltarzhevskaia
N D
ND
Vershinina
S F
SF
Gornaeva
G F
GF
Pustovalov
Iu I
IuI
Korovina
M A
MA
D000279:Administration, Cutaneous; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D051381:Rats
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil