title: Parkinson's disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living Parkinson's, Alzheimer's and vascular dementia patients.
abstract: Antioxidant profiles in Parkinson's disease (PD; n = 15), dementias of Alzheimer's type (DAT; 18) and Vascular (VD; 15), and control subjects (C; 14) were studied. Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU) and thiobarbituric acid reactive substances (TBARS) were measured in erythrocytes; antioxidant capacity (TRAP) in plasma. Biochemical variables were analyzed simultaneously using multi-variate and non-parametric methods. Clinical diagnostic resulted associated with the main source of variability in antioxidant variables (Kruskal-Wallis: H = 32.58, p = 0.000001). Comparison of PD and C resulted highly significant (z = 4.47, p = 0.000047), demonstrating an association between oxidative stress and PD. SOD and TBARS were significantly higher in pathological groups against C (p = 0.0000001, p = 0.051); TRAP resulted lower (p = 0.00015). Discriminant functions constructed using biochemical variables separated pathological groups (93% success) from C, and DAT (88.9%) from VD (73.3%); but not PD from DAT or VD. Antioxidant profiles of PD patients showed characteristics overlapping with DAT (60%) and with VD (40%), suggesting biochemical similarities between them.
authors.affiliation: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. serraja@hotmail.com
authors.forename: J A
authors.initials: JA
authors.lastname: Serra
authors.forename: R O
authors.initials: RO
authors.lastname: Domínguez
authors.forename: E S
authors.initials: ES
authors.lastname: de Lustig
authors.forename: E M
authors.initials: EM
authors.lastname: Guareschi
authors.forename: A L
authors.initials: AL
authors.lastname: Famulari
authors.forename: E L
authors.initials: EL
authors.lastname: Bartolomé
authors.forename: E R
authors.initials: ER
authors.lastname: Marschoff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D015140:Dementia, Vascular / Q000378:metabolism*; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D000975:Antioxidants