[Properties of mucosal antibodies].
Mucosal antibodies consist of a variety of molecules, including secretory IgA and local IgG, involved in the first immune barrier of defence against pathogens. They account for the majority of daily synthesized immunoglobulins in the body and mostly depend on the secretory immune system which is independent from its systemic counterpart. Acting by immune exclusion and immune elimination, these immunoglobulins correspond to preimmune poly-reactive natural antibodies and to antigen-induced antibodies. Recent progress in this field have suggested new approaches of mucosal vaccines preventing the entry of pathogens in the body.
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INSERM UR 430 Hôpital Broussais 96, rue Didot, 75674 Paris.
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D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D005544:Forecasting; D006801:Humans; D007113:Immunity, Innate; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis / Q000737:chemistry / Q000276:immunology*; D007072:Immunoglobulin D / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000737:chemistry / Q000276:immunology*; D007144:Immunoglobulin J-Chains / Q000737:chemistry / Q000276:immunology; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000737:chemistry / Q000276:immunology*; D018448:Models, Immunological; D009092:Mucous Membrane / Q000276:immunology*; D010581:Peyer's Patches / Q000276:immunology; D014611:Vaccination / Q000379:methods
D007071:Immunoglobulin A, Secretory; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M; C033027:secretory IgM