[The problem of restoring bone marrow, irradiated during radiotherapy of Hodgkin's disease patients].
The results of bone marrow (BM) visualisation of 663 irradiated regions were analysed. In all cases BM absorbed doses varied between 10-40 Gy. Active accumulation of 99mTc-colloids was observed in 48 out of 60 regions irradiated within 20 Gy. This pattern proved the possibility of effective and rapid hematopoietic regeneration after low-dose radiotherapy. On the contrary, during the first 6 months after BM irradiation with doses over 25 Gy we detected prominent depression of tracer uptake in 86.2% of all regions. It was shown that intensity of BM regeneration reached its peak during the second half-year after irradiation within 25-40 Gy. BM recovery during this period was dose dependent and was detected in 47.7% areas irradiated with 30 Gy and 24.7%--with 40 Gy. Regression analysis revealed significant correlation of postradiotherapy hematopoietic status with the value of BM absorbed dose and the time after the end of radiotherapy. Scintigraphic patterns of BM regeneration were registered in 69 of 89 (77.5%) regions irradiated within 25-30 Gy and only in 96 out of 231 (41.6%)--within 35-40 Gy.
Kanaev
S V
SV
N.N. Petrov Research Institute of Oncology, St. Petersburg.
Novikov
S N
SN
D001853:Bone Marrow / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006410:Hematopoiesis; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects; D012044:Regression Analysis