Malignant transformation of multiple dermal cylindromas.
Cylindromas are benign tumours arising as small, solitary, slow-growing nodules on the head and neck. Multiple cylindromas may form a 'turban tumour' in the autosomal dominant Brooke-Spiegler syndrome. We report two unusual cases of multiple cylindromas with transformation into cylindrocarcinomas. The first patient, a 63-year-old white woman, developed a cylindrocarcinoma on pre-existing multiple cylindromas on her right shoulder. Eight months after resection she developed a lymph node metastasis in the right axilla. The second patient, a 68-year-old white woman, presented with multiple cylindromas of the scalp. One of these transformed into a cylindrocarcinoma, infiltrating the dura mater, with local recurrence 2 years after incomplete resection and postoperative radiation.
Durani
B K
BK
Department of Dermatology, University of Heidelberg, Voss-str. 2, 69115 Heidelberg, Germany.
Kurzen
H
H
Jaeckel
A
A
Kuner
N
N
Naeher
H
H
Hartschuh
W
W
D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology* / Q000556:secondary; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D012535:Scalp; D012878:Skin Neoplasms / Q000473:pathology*