Synthesis of novel quinolines, pyranoquinolines, furoquinolines, thieno-quinoline and their effect on the ultrastructure of some pathogenic microorganisms.
New series of quinolines 2, 6, 7, 9, 14-17, 20, 21; pyrano[3,2-c]quinolines 3, 4, 5, 11; furo[3,2-c]quinolines 8, 18; oxazino[5,6-c]quinoline 19 and thieno[3,4-b]quinoline 22 were prepared and the impact of synthesized compounds on some pathogenic microorganisms isolated from clinical samples was studied. Compounds 4, 11 and 14 were found to be the most active against all tested microorganisms. The compound 14 which showed higher activity was selected to study its action on the ultrastructure of Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. Death of numerous cells, destruction of the cell wall, cell contents poured into the medium and impairment of metabolism, were observed.
Ghorab
M M
MM
Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt. ghorabmoustafa@hotmail.com
Abdel-Hamide
S G
SG
Farrag
H A
HA
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects / Q000648:ultrastructure*; D024841:Fluoroquinolones; D005658:Fungi / Q000187:drug effects / Q000648:ultrastructure*; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D008854:Microscopy, Electron; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007202:Indicators and Reagents