[Features of primary structure of genes and proteins from passaged variations of measles virus].
Primary structure and proteins of measles virus variants passaged in tissue culture were studied. The findings suggest that genetic determinants responsible for measles virus attenuation are not linked with the genes coding for envelope proteins and nucleoprotein of this virus. However the detected nucleotide substitutions can be considered as the main prerequisites for the appearance of mutations in other regions of viral genome, leading to decrease of virulence for humans.
Markushin
S G
SG
Taros
L Iu
LIu
Rota
P
P
Bellini
V
V
Koptiaeva
I B
IB
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D001483:Base Sequence; D002522:Chlorocebus aethiops; D046508:Culture Techniques; D005814:Genes, Viral; D008459:Measles virus / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D009154:Mutation; D012367:RNA, Viral; D012692:Serial Passage; D014709:Vero Cells; D014764:Viral Proteins / Q000235:genetics; D014774:Virulence
D012367:RNA, Viral; D014764:Viral Proteins