title: Combretoxazolones: synthesis, cytotoxicity and antitumor activity.
abstract: Two series of combretoxazolones including 3,4-diaryloxazolones (6) and 4,5-diaryloxazolones (7) were synthesized and evaluated for cytotoxicity and antitumor activity. Both series showed strong cytotoxicities against a variety of tumor cell lines. Compound 6g exhibited a significant antitumor activity in BDF1 mice bearing B16 murine melanoma cells with inhibition rates of 67 and 61% at 100 and 30 mg/kg/day, respectively.
authors.affiliation: College of Pharmacy, Chungnam National University, Taejon 305-764, Republic of Korea.
authors.forename: N H
authors.initials: NH
authors.lastname: Nam
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: Y J
authors.initials: YJ
authors.lastname: You
authors.forename: D H
authors.initials: DH
authors.lastname: Hong
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: B Z
authors.initials: BZ
authors.lastname: Ahn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D010080:Oxazoles