title: Exposure to metal ions and susceptibility to dental caries.
abstract: Results from several epidemiologic studies have shown that there are large differences in the prevalence of dental caries from one region to another within the United States as well as in other countries. It has been postulated that the observed differences may be attributed in part at least to exposure to trace elements such as selenium, vanadium, molybdenum, strontium, and lead. Although data from epidemiologic studies usually support this hypothesis, direct evidence is sparse with the possible exception of exposure to lead. Data from several epidemiologic studies and animal-based research support the concept that lead is a caries-promoting element. Lead mimics calcium in several respects and may affect development of teeth and salivary glands, clearly enhancing susceptibility to dental caries. Elevated blood levels are found most commonly in persons residing in inner cities, particularly among the poor. Many states require blood lead level to be monitored in young children. Where feasible, these records should form part of health history and be available to the treating dental practitioner to ensure that extra preventive procedures may be implemented.
authors.affiliation: Center for Oral Biology, University of Rochester, NY 14642, USA. William_Bowen@urmc.rochester.edu
authors.forename: W H
authors.initials: WH
authors.lastname: Bowen
mesh_terms: D000818:Animals; D003731:Dental Caries / Q000209:etiology*; D003733:Dental Caries Susceptibility / Q000187:drug effects*; D003743:Dental Enamel / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D007477:Ions; D007854:Lead / Q000009:adverse effects* / Q000378:metabolism; D016239:MEDLINE; D014131:Trace Elements / Q000009:adverse effects*
chemical_list: D007477:Ions; D014131:Trace Elements; D007854:Lead