Anaphylactoid reactions associated with menstruation affecting two sisters.
Cyclical anaphylactoid reactions associated with menstruation are exceedingly rare. We report two sisters who were both affected, one severely and one mildly. Treatment involved suppression of menstruation and use of a cyclooxygenase-2 (COX-2) inhibitor. An abnormal reaction to prostaglandins, perhaps produced by COX-2 enzyme activity in the endometrium, is a possible mechanism.
Simpson
G
G
Department of Thoracic Medicine, Cairns Base Hospital, QLD.
Roomes
D
D
Humphrey
M D
MD
D000328:Adult; D000707:Anaphylaxis / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008598:Menstruation / Q000235:genetics / Q000276:immunology*; D009679:Nuclear Family; D011720:Pyrazoles; D018570:Risk Assessment; D013449:Sulfonamides / Q000008:administration & dosage*; D014581:Urticaria / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics
D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib