title: Influence of bone environment on ceramic osteointegration in spinal fusion: comparison of bone-poor and bone-rich sites.
abstract: Quantitative experimental data showed differences in bone quality and ceramic incorporation between bone-rich and bone-poor implantation sites. Bone in-growth was significantly lower for ceramic implanted at a lumbar intertransverse than a laminar site. Bone-marrow enrichment of the lumbar intertransverse site (regarded as bone-poor) greatly facilitated ceramic osteointegration. The vertebral interbody site, despite theoretical richness in osteogenic precursor cells, might be bone-poor at the time of grafting as compared to the reference iliac crest site. These data have important clinical implications concerning the potential benefit of enriching both bone-poor and bone-rich sites.
authors.affiliation: Department of Orthopaedic Surgery, Hôtel Dieu, University Hospital of Nantes, France. joel.delecrin@chu-nantes.fr
authors.forename: J
authors.initials: J
authors.lastname: Delécrin
authors.forename: C
authors.initials: C
authors.lastname: Deschamps
authors.forename: M
authors.initials: M
authors.lastname: Romih
authors.forename: D
authors.initials: D
authors.lastname: Heymann
authors.forename: N
authors.initials: N
authors.lastname: Passuti
mesh_terms: D016026:Bone Marrow Transplantation; D001842:Bone and Bones / Q000503:physiopathology*; D002516:Ceramics; D006801:Humans; D016348:Osseointegration / Q000502:physiology*; D019736:Prostheses and Implants; D013123:Spinal Fusion; D013234:Stem Cells / Q000502:physiology