Uncoupling protein 3 biological activity.
The hypothesis that uncoupling protein 3 (UCP3) is an uncoupling protein involved in heat dissipation is not unequivocally supported. An update of in vitro, ex vivo and in vivo studies testing this hypothesis is presented. Data are provided showing that exercise induces a fatty acid-dependent increase in muscle UCP3 mRNA in humans. The proposed positive correlation between glycolytic capacity and UCP3 level in various muscle-fibre types in the mouse is reassessed. Finally, an association between an intronic polymorphism of UCP3 and adiposity is reported.
Giacobino
J P
JP
Département de Biochimie Médicale, Centre Médical Universitaire, CH-1211 Genève 4, Switzerland. Jean-Paul.Giacobino@medecine.unige.ch
D000818:Animals; D015153:Blotting, Western; D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology*; D005508:Food Deprivation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007473:Ion Channels; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D013696:Temperature; D014018:Tissue Distribution; D000071247:Uncoupling Protein 3
D002352:Carrier Proteins; D007473:Ion Channels; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; C000604392:UCP3 protein, human; C000604393:Ucp3 protein, mouse; C000604394:Ucp3 protein, rat; D000071247:Uncoupling Protein 3; D005947:Glucose