A mathematical model for the immunosenescence.
We propose a model for the dynamics of the immune system by considering the subpopulations of virgin and memory T lymphocytes on a time scale corresponding to the human life span. In the deterministic balance equation we introduce a fluctuating term in order to take into account the chronic antigenic stress. Starting from the hypothesis that the depletion of virgin cells with cytotoxic properties (CD8+) is a mortality marker, the model provides survival curves quite similar to the demographic curves.
Luciani
F
F
Dipartimento di Fisica, Università di Bologna, Via Irnerio 46, 40126 Bologna.
Turchetti
G
G
Franceschi
C
C
Valensin
S
S
D000375:Aging / Q000276:immunology*; D015415:Biomarkers; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D002452:Cell Count; D016923:Cell Death; D002470:Cell Survival; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007156:Immunologic Memory; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D015415:Biomarkers