Endocrine sequelae of cancer therapy in childhood.
New treatments for neoplastic diseases of childhood have significantly increased patients' long-term survival and the importance of recognizing and correcting late complications of medical therapy. In this review, we examine both central nervous system (CNS) and non-CNS-related endocrine morbidities associated with chemotherapy and radiation therapy of childhood cancer. These include effects on growth, puberty, fertility, thyroid and adrenal function which may present many years after the successful treatment of underlying disease.
Diamond
F B
FB
Department of Pediatrics University of South Florida College of Medicine, Tampa, USA.
Bercu
B B
BB
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects / Q000528:radiation effects; D002648:Child; D004700:Endocrine System Diseases / Q000139:chemically induced*; D005260:Female; D019382:Human Growth Hormone / Q000502:physiology; D006801:Humans; D007027:Hypothalamic Diseases / Q000209:etiology; D008297:Male; D009369:Neoplasms / Q000209:etiology*; D010049:Ovarian Diseases / Q000209:etiology; D010900:Pituitary Diseases / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D013733:Testicular Diseases / Q000209:etiology; D013959:Thyroid Diseases / Q000209:etiology
D000970:Antineoplastic Agents; D019382:Human Growth Hormone