Studies on the oxidative stress in alcohol abusers in China.
OBJECTIVE
In order to study the relationship between alcohol abuse and oxidative stress, and to identify oxidative damage of alcohol abuse in human bodies.


METHODS
80 cases of male alcoholics (AL) aged 40 years old and 80 cases of male healthy volunteers (HV) of the same age without drinking history were investigated by measuring concentrations of vitamin C (VC), vitamin E (VE) and beta-carotene (beta-CAR) in plasma as well as activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in RBC with spectrophotometric assays.


RESULTS
Compared with the average values (AV) of the above biochemical parameters in the HV group, the average values of VC, VE and beta-CAR in plasma and the activities of SOD, CAT and GSH-Px in RBC in the AL group were significantly decreased (P = 0.0000). The findings in linear regression and correlation analysis for 80 alcoholics showed that with the prolonged drinking duration and increased daily drinking quantity, the values of VC, VE and beta-CAR in plasma as well as SOD, CAT and GSH-Px in RBC in the alcoholics were gradually decreased (P = 0.000), representing a respectively significant linear negative correlation. The analysis of stepwise regression and correlation revealed that the drinking duration had the closest correlation with the values of VE in plasma as well as CAT and GSH-Px in RBC, while the daily drinking quantity had the closest correlation with the values of VC, VE and beta-CAR in plasma as well as SOD and GSH-Px in RBC.


CONCLUSIONS
The findings of the present study suggested that the oxidative stress in the alcoholics became pathologically intensified, leading to potential oxidative damages in their bodies. Therefore, alcoholics should abstain from alcohol drinking, and should take as supplements suitable dosage of antioxidants per day such as VC, VE, beta-CAR and others to moderate potential oxidative damages in their bodies.
Zhou
J F
JF
The Second Affiliated Hospital, Medical College of Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China.
Chen
P
P
D000328:Adult; D000437:Alcoholism / Q000503:physiopathology*; D000975:Antioxidants / Q000032:analysis* / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000097:blood; D016022:Case-Control Studies; D004912:Erythrocytes / Q000502:physiology; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000097:blood; D019207:beta Carotene / Q000097:blood
D000975:Antioxidants; D019207:beta Carotene; D014810:Vitamin E; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid