title: Hearing loss as a presenting symptom of cleidocranial dysplasia.
abstract: OBJECTIVE
  To report two cases of cleidocranial dysplasia in which hearing loss was the first presenting symptom.
  
  
  METHODS
  Retrospective case review.
  
  
  METHODS
  Two cases of cleidocranial dysplasia, a rare autosomal dominant skeletal dysplasia affecting both membranous and enchondral bone formation.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Clinical, audiometric, and imaging diagnostic procedures.
  
  
  CONCLUSIONS
  With this report, we want to illustrate the possibility of a rare genetic disorder as the underlying cause of hearing loss. We also want to emphasize the need for a multidisciplinary approach and evaluation of unexplained hearing loss to obtain a correct diagnosis, which is important for genetic counseling and management of the patient and his or her family.
authors.affiliation: Department of Otolaryngology, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Dhooge
authors.forename: B
authors.initials: B
authors.lastname: Lantsoght
authors.forename: M
authors.initials: M
authors.lastname: Lemmerling
authors.forename: B
authors.initials: B
authors.lastname: Vanzieleghem
authors.forename: G
authors.initials: G
authors.lastname: Mortier
mesh_terms: D001301:Audiometry, Pure-Tone; D001844:Bone Conduction / Q000502:physiology; D002648:Child; D002973:Cleidocranial Dysplasia / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006314:Hearing Loss, Conductive / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male