Is there any significance for intracellular crystals in plasma cells from patients with monoclonal gammopathies?
Several plasma cells morphological changes have been described in monoclonal gammopathies, including intracytoplasmic crystals. We report one case of indolent kappa-chain multiple myeloma with renal insufficiency, featuring plasma cells with Auer-rod-like intracytoplasmic inclusions. The relationship between such aberrations and those found in multiple-myeloma-associated adult Fanconi syndrome is discussed. The significance of intracellular storage and crystallisation of immunoglobulin within plasma cells remains partially unknown.
Gardais
J
J
Laboratoire d'Hématologie, Centre Hospitalier Universitaire, Angers, France. JaGardais@chu-angers.fr
Geneviève
F
F
Foussard
C
C
Delisle
V
V
Zandecki
M
M
D000368:Aged; D001797:Blood Protein Electrophoresis; D001853:Bone Marrow / Q000473:pathology; D003460:Crystallization; D004587:Electrophoresis, Agar Gel; D005198:Fanconi Syndrome / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007677:Kidney Function Tests; D009101:Multiple Myeloma / Q000097:blood / Q000150:complications / Q000473:pathology*; D009194:Myeloma Proteins / Q000032:analysis*; D010014:Osteolysis / Q000209:etiology; D010265:Paraproteinemias / Q000150:complications / Q000473:pathology; D010950:Plasma Cells / Q000648:ultrastructure*
D007145:Immunoglobulin kappa-Chains; D009194:Myeloma Proteins