title: Does stress influence ampicillin concentration in serum and tissues?
abstract: Exercise produces changes of drug levels in plasma and increases the concentration of free fatty acids (FFAs), which may interfere with drug-protein binding. FFAs seem to play an antagonistic role to drugs since they have a strong binding capacity to serum albumin. The aim of this study was to evaluate the influence of the consecutive exercise-induced stress in ampicillin levels. Two groups of Wistar rats were used. Group A consisted of six subgroups that were subjected to cold swimming (4 degrees C) for 5, 10, 15, 20,25, 30 days respectively. Group B was the control group. The animals were injected im. with ampicillin (1 g/Kg/8h in 5 doses). Results showed that exercise enhanced stress parameters (FFAs, adrenal weight, Ht%) and led to an ampicillin increase in all experimental groups comparatively to controls.
authors.affiliation: Department of Pharmacology, Medical School, University of Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Tesseromatis
authors.forename: A
authors.initials: A
authors.lastname: Trichilis
authors.forename: E
authors.initials: E
authors.lastname: Tsivos
authors.forename: J
authors.initials: J
authors.lastname: Messari
authors.forename: H
authors.initials: H
authors.lastname: Triantaphyllidis
authors.forename: D D
authors.initials: DD
authors.lastname: Varonos
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000667:Ampicillin / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006400:Hematocrit; D007273:Injections, Intramuscular; D008297:Male; D009929:Organ Size; D010406:Penicillins / Q000097:blood / Q000493:pharmacokinetics*; D005082:Physical Exertion / Q000502:physiology*; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism*; D013550:Swimming / Q000502:physiology; D014018:Tissue Distribution
chemical_list: D005230:Fatty Acids, Nonesterified; D010406:Penicillins; D000667:Ampicillin