title: Clinical applications of bone graft substitutes in spine surgery: consideration of mineralized and demineralized preparations and growth factor supplementation.
abstract: Bone graft substitutes may be broadly classified as mineralized and demineralized preparations. This article reviews the basic science and biology underlying each preparation. A review of the clinical and experimental applications of each preparation follows. The text concludes with a review of growth factors as biological supplements.
authors.affiliation: Department of Orthopedic Surgery, UC San Francisco, CA 94143, USA. bervens@orthosurg.ucsf.edu
authors.forename: S
authors.initials: S
authors.lastname: Berven
authors.forename: B K
authors.initials: BK
authors.lastname: Tay
authors.forename: F S
authors.initials: FS
authors.lastname: Kleinstueck
authors.forename: D S
authors.initials: DS
authors.lastname: Bradford
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018775:Bone Demineralization Technique; D001857:Bone Matrix / Q000637:transplantation*; D002516:Ceramics; D006133:Growth Substances / Q000627:therapeutic use*; D006801:Humans; D019736:Prostheses and Implants; D013123:Spinal Fusion / Q000379:methods*; D013131:Spine / Q000601:surgery*; D014184:Transplantation, Homologous
chemical_list: D001672:Biocompatible Materials; D006133:Growth Substances