title: Apparent anticipation and heterogeneous transmission patterns in familial Hodgkin's and non-Hodgkin's lymphoma: report from a study based on Swedish cancer database.
abstract: The goal of this study was to test whether there is genetic anticipation in Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). We analyzed 102 parent-child pairs with HD or NHL, based upon the Swedish Cancer Database. We identified 18 sib-pairs (2 HD and 16 NHL) and 102 parent-child pairs (13 HD/HD, 56 NHL/NHL, 25 HD/NHL, and 8 NHL/HD). The mean anticipation score was 27.6 years for all 102 parent-child pairs. The anticipation means were 13.8, 28.4, 19.8 and 35.8 years for these pair-type groups, respectively. These differences between the age of onset for each affected parent-child pair type were statistically significant. The anticipation level was more pronounced among the NHUNHL pairs than in the HD/HD pairs (difference = 12.6 years, p = 0.0003). These results allow us to conclude with confidence that there is an apparent genetic anticipation in familial HD and NHL in the Swedish population.
authors.affiliation: Center for Inherited Disease Research, Department of Pediatrics, Johns Hopkins University, USA.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Shugart
authors.forename: K
authors.initials: K
authors.lastname: Hemminki
authors.forename: P
authors.initials: P
authors.lastname: Vaittinen
authors.forename: A
authors.initials: A
authors.lastname: Kingman
mesh_terms: D020132:Anticipation, Genetic; D016208:Databases, Factual; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D009679:Nuclear Family; D013548:Sweden