title: Marginal zone B-cell lymphoma of the salivary gland arising in chronic sclerosing sialadenitis (Küttner tumor).
abstract: We report a case of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type of the salivary gland arising in a background of chronic sclerosing sialadenitis. Chronic sclerosing sialadenitis is a common fibrosing chronic inflammatory lesion of the submandibular gland, which is thought to be the result of sialolithiasis, and is not associated with a systemic autoimmune disease. Salivary MALT lymphomas are typically associated with lymphoepithelial sialadenitis (LESA) in a patient with or without Sjögren's syndrome. Our case of salivary MALT lymphoma was neither preceded by Sjögren's syndrome nor accompanied by LESA. This case suggests that chronic inflammatory processes other than Sjögren's syndrome may provide a substrate for the development of MALT lymphoma.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Ochoa
authors.forename: N L
authors.initials: NL
authors.lastname: Harris
authors.forename: B Z
authors.initials: BZ
authors.lastname: Pilch
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D002908:Chronic Disease; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D017254:Leukemic Infiltration / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008297:Male; D012793:Sialadenitis / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013363:Submandibular Gland / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013365:Submandibular Gland Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor