title: Phenotypic characteristics of colo-rectal cancer in I1307K APC germline mutation carriers compared with sporadic cases.
abstract: The I1307K APC germline mutation is associated with an increased risk to colo-rectal cancer (CRC). Whether and to what extent the phenotype of CRC in mutation carriers differs from sporadic cases, remains unknown. To gain insight into this issue, we analysed 307 unselected Israeli patients with CRC, who were treated in a single medical centre, for harbouring the I1307K mutation. Twenty-eight mutation carriers (9.1%) were detected. Two of 28 mutation carriers (7.1%) and 93/277 (33.6%) of non-carriers, were of non-Ashkenazi origin (P < 0.01). In 74/278 (26.6%) of the sporadic cases, and only 1/28 (3.6%) of mutation carriers (3.6%) the tumour was located in the right colon (P < 0.01). Mutation carriers had a more advanced disease stage (14/28 - 50% Dukes C), as compared with 60 (19.5%) of non-carriers (P = 0.02). The mean age at diagnosis was similar: 65 (+/- 9.7) years and 66.3 (+/- 11.6) years, for mutation carriers and non-carriers, respectively. No statistical differences were noted between the two groups in sex distribution, tumour grade, and family history of cancer. We conclude that early age at diagnosis and family history of cancer cannot be used to predict who is likely to harbour the I1307K APC germline mutation carriers. However, the tumours in patients with this mutation appear different than those without, are less likely to be proximal and more likely to be advanced than tumours in non-carriers.
authors.affiliation: Institute of Oncology Rabin Medical Center, Beilinson Campus, Petach-Tikvah, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Figer
authors.forename: R
authors.initials: R
authors.lastname: Shtoyerman-Chen
authors.forename: A
authors.initials: A
authors.lastname: Tamir
authors.forename: R
authors.initials: R
authors.lastname: Geva
authors.forename: L
authors.initials: L
authors.lastname: Irmin
authors.forename: D
authors.initials: D
authors.lastname: Flex
authors.forename: L
authors.initials: L
authors.lastname: Theodor
authors.forename: A
authors.initials: A
authors.lastname: Sulkes
authors.forename: S
authors.initials: S
authors.lastname: Sadetzki
authors.forename: S
authors.initials: S
authors.lastname: Bar-Meir
authors.forename: E
authors.initials: E
authors.lastname: Friedman
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm; D005260:Female; D017491:Genes, APC; D018095:Germ-Line Mutation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010375:Pedigree; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012737:Sex Factors
chemical_list: D004273:DNA, Neoplasm