Continuous feed medication with nitroscanate for the removal of Hymenolepis nana in naturally infected mice and rats.
In this study, the effects of nitroscanate were investigated in naturally acquired Hymenolepis nana infections in rats and mice. The natural infection was determined by centrifugal flotation technique of faeces. The infected rats and mice were divided into two treatment and two control groups (N = 10). Nitroscanate at the dose of 50 mg/kg per day was given in the diet for 4 days. The rats and mice of treatment groups were necropsied on 7th day after the last treatment together with those of control groups. Following necrospsy, in the treatment group a geometric mean of 1.07 Hymenolepis nana were recovered out of ten mice, compared with 8.14 in the control group. In the rat treatment group no Hymenolepis nana were found in ten rats, while the control group showed a geometric mean of 6.23. Nitroscanate was found to be effective 100% and 86.8% at the treatment of H. nana infection in rats and mice respectively.
Gönenç
B
B
Ankara University, Faculty of Veterinary Medicine, Ankara, Turkey. gonenc@veterinary.ankara.edu.tr
Sarimehmetoğlu
H O
HO
D000821:Animal Feed; D000818:Animals; D000830:Animals, Laboratory; D000923:Anticestodal Agents / Q000008:administration & dosage*; D005243:Feces / Q000469:parasitology; D005260:Female; D006925:Hymenolepiasis / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D051379:Mice / Q000469:parasitology*; D010647:Phenyl Ethers / Q000008:administration & dosage*; D051381:Rats / Q000469:parasitology*; D012376:Rodent Diseases / Q000188:drug therapy*; D013607:Tablets; D013861:Thiocyanates / Q000008:administration & dosage*; D016896:Treatment Outcome
D000923:Anticestodal Agents; D010647:Phenyl Ethers; D013607:Tablets; D013861:Thiocyanates; C011042:nitroscanate