Plasminogen activators and their inhibitor in bone tumors and tumor-like damages.
Expression of urokinase- and tissue-type plasminogen activators and their inhibitor PAI-1 in the cytosolic fraction of 20 osteosarcomas, 20 chondrosarcomas, 13 giant-cell bone tumors, 5 Ewing's sarcomas, and 7 osteochondral exostoses was studied by enzyme immunoassay. The content of urokinase-type plasminogen activator increased, while the concentration of tissue-type plasminogen activator decreased in bone tumors of various histological compositions compared to osteochondral exostoses. A positive correlation was found between PAI-1 content and the volume of osteo- and chondrosarcomas. Expression of urokinase-type plasminogen activator increased in patients with primary osteosarcomas characterized by early generalization of the pathological process.
Kushlinskii
N E
NE
N. N. Blokhin Russian Oncological Center, Russian Academy of Medical Sciences, Moscow.
Yusifov
A I
AI
Gershtein
E S
ES
Solov'ev
Y N
YN
Trapeznikov
N N
NN
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology*; D002648:Child; D002813:Chondrosarcoma / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D003600:Cytosol / Q000201:enzymology / Q000378:metabolism; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015831:Osteochondroma / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D012516:Osteosarcoma / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism*; D012512:Sarcoma, Ewing / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D017395:Plasminogen Activator Inhibitor 1; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator