[Two neonates with vesicular skin lesions due to incontinentia pigmenti].
In two neonate girls with vesicular skin lesions, incontinentia pigmenti (Bloch-Sulzberger syndrome) was diagnosed. This rare X-linked dominant ectodermal disease can cause abnormalities in several organ systems. Most prominent are the dermatological abnormalities, developing in 4 stages: the vesicular stage, the verrucous stage, the hyperpigmentation phase, and the atrophic phase. In addition to the cutaneous manifestations, many patients have anomalies of nails, hair and teeth. Serious related abnormalities of the eyes (intraocular vasculopathy) and central nervous system (convulsions, mental retardation) may occur. In 1989 the locus for the incontinentia pigmenti mutation was shown to be present on Xq28. Recently it was shown that the causative mutation is located on the NEMO ('NF-kappa B essential modulator') gene. A NEMO knock-out mouse model shows a dermatopathy of a transient nature, resembling the skin lesions in patients with incontinentia pigmenti.
Winterberg
D H
DH
Academisch Medisch Centrum/Universiteit van Amsterdam, Postbus 22.700, 1100 DE Amsterdam.
van Tijn
D A
DA
Smitt
J H
JH
Winterberg
S
S
Vomberg
P P
PP
D003937:Diagnosis, Differential; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D051550:I-kappa B Kinase; D007184:Incontinentia Pigmenti / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D009154:Mutation; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D009264:Nails, Malformed / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000235:genetics*; D014071:Tooth Abnormalities / Q000235:genetics; D014960:X Chromosome
D016328:NF-kappa B; D017346:Protein Serine-Threonine Kinases; C496559:CHUK protein, human; D051550:I-kappa B Kinase; C496560:IKBKB protein, human; C496565:IKBKE protein, human