title: A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles.
abstract: OBJECTIVE
  To compare the efficacy of Crinone 8% intravaginal progesterone gel vs. IM progesterone for luteal phase and early pregnancy support after IVF-ET.
  
  
  METHODS
  Randomized, open-label study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Two hundred and one women undergoing IVF-ET.
  
  
  METHODS
  Women were randomized to supplementation with Crinone 8% (90 mg once daily) or IM progesterone (50 mg once daily) beginning the day after oocyte retrieval.
  
  
  METHODS
  Pregnancy, embryo implantation, and live birth rates.
  
  
  RESULTS
  The women randomized to luteal phase supplementation with IM progesterone had significantly higher clinical pregnancy (48.5% vs. 30.4%; odds ratio [OR], 2.16; 95% confidence interval [CI], 1.21, 3.87), embryo implantation (24.1% vs. 17.5%; OR, 1.89; 95% CI, 1.08, 3.30), and live birth rates (39.4% vs. 24.5%; OR, 2.00; 95% CI, 1.10, 3.70) than women randomized to Crinone 8%.
  
  
  CONCLUSIONS
  In women undergoing IVF-ET, once-a-day progesterone supplementation with Crinone 8%, beginning the day after oocyte retrieval, resulted in significantly lower embryo implantation, clinical pregnancy, and live birth rates compared with women supplemented with IM progesterone.
authors.affiliation: Center for Reproductive Medicine, Division of Reproductive Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Propst
authors.forename: J A
authors.initials: JA
authors.lastname: Hill
authors.forename: E S
authors.initials: ES
authors.lastname: Ginsburg
authors.forename: S
authors.initials: S
authors.lastname: Hurwitz
authors.forename: J
authors.initials: J
authors.lastname: Politch
authors.forename: E H
authors.initials: EH
authors.lastname: Yanushpolsky
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D000367:Age Factors; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005782:Gels / Q000008:administration & dosage; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D018709:Statistics, Nonparametric
chemical_list: C400424:Crinone; D005782:Gels; D011374:Progesterone; D004958:Estradiol