Enantioseparation of gantofiban precursors on chiral stationary phases of the poly-(N-acryloyl amino acid derivative)-type.
A separation strategy for the preparative enantioseparation of intermediates of the synthesis route towards the new antithrombotic drug Gantofiban is outlined. The selectivities of six different intermediates on a series of chiral stationary phases of the poly-[N-(meth-)acryloyl amino acid derivative]-type are determined. The separations are optimized with respect to high enantioselectivities and good solubilities in the mobile phase. For three optimized combinations of chiral stationary and mobile phases the separation parameters for a simulated moving bed-systems are determined.
Schulte
Michael
M
Merck KGaA, Frankfurter Strasse 250, D-64271 Darmstadt, Germany. michael.schulte@merck.de
Devant
R
R
Grosser
R
R
D000596:Amino Acids / Q000737:chemistry*; D005343:Fibrinolytic Agents / Q000032:analysis* / Q000737:chemistry; D010080:Oxazoles / Q000032:analysis* / Q000737:chemistry; D010879:Piperazines / Q000032:analysis* / Q000737:chemistry; D011355:Prodrugs / Q000032:analysis* / Q000737:chemistry; D013237:Stereoisomerism
D000596:Amino Acids; D005343:Fibrinolytic Agents; D010080:Oxazoles; D010879:Piperazines; D011355:Prodrugs; C449060:gantofiban