title: Vulvar melanoma: a retrospective analysis and literature review.
abstract: OBJECTIVE
  This review focuses on current directions in the staging and treatment of melanoma of the vulva.
  
  
  METHODS
  All women treated for invasive melanoma of the vulva at the University of Virginia Health Sciences Center from 1980 through 2000 were identified through a retrospective review of the records of the Division of Gynecologic Oncology. Their treatments and outcomes were then analyzed and presented.
  
  
  RESULTS
  Over the 20-year study period, 14 cases of melanoma of the vulva were identified. Of the 14 patients treated with curative intent, 6 developed recurrences following the completion of primary therapy, and all are dead from their disease. The mean duration from completion of therapy to recurrence was 7.5 months; the mean survival following recurrence was 17 months.
  
  
  CONCLUSIONS
  One-centimeter skin margins appear adequate for vulvar melanomas <1 mm thick, and 2-cm margins appear adequate for intermediate-thickness melanomas (1-4 mm). In all cases it is necessary to include at least a 1-cm-deep margin extending through the subcutaneous fat to the muscular fascia below. Elective node dissection seems to offer no additional advantage in superficial lesions <0.76 mm thick, and its role in deeper lesions is still uncertain.
authors.affiliation: Division of Gynecologic Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA. wpi9d@hscmail.mcc.virginia.edu
authors.forename: W P
authors.initials: WP
authors.lastname: Irvin
authors.forename: R L
authors.initials: RL
authors.lastname: Legallo
authors.forename: M H
authors.initials: MH
authors.lastname: Stoler
authors.forename: L W
authors.initials: LW
authors.lastname: Rice
authors.forename: P T
authors.initials: PT
authors.lastname: Taylor
authors.forename: W A
authors.initials: WA
authors.lastname: Andersen
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000628:therapy*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000628:therapy*