Multiple functions of mouse zona pellucida glycoprotein mZP3, the sperm receptor.
Zona pellucida glycoprotein mZP3 is a structural glycoprotein, a sperm receptor, and an acrosome reaction-inducer. The latter two functions are mediated, at least in part, by mZP3 oligosaccharides. mZP3 is unique to mammalian eggs, from mice to humans, although related glycoproteins are found in vitelline envelopes of a variety of eggs, from fish to birds.
Wassarman
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Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. paul.wassarman@mssm.edu
Litscher
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D020101:Acrosome Reaction / Q000502:physiology; D000818:Animals; D004527:Egg Proteins / Q000502:physiology*; D005260:Female; D005306:Fertilization; D008297:Male; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D009865:Oocytes / Q000254:growth & development / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D013094:Spermatozoa / Q000378:metabolism*; D015044:Zona Pellucida / Q000737:chemistry*; D000072216:Zona Pellucida Glycoproteins
D004527:Egg Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D000072216:Zona Pellucida Glycoproteins