T-cell responses to oligodendrocyte-specific protein in multiple sclerosis.
Oligodendrocyte-specific protein (OSP) is concentrated in CNS myelin and is a potential autoantigen in the development of multiple sclerosis (MS). We performed proliferation assays with lymphocytes from MS patients and normal controls. OSP peptide-induced proliferation was common in relapsing-remitting MS and controls samples but was less pronounced in samples from secondary progressive MS subjects. These data demonstrate that OSP-reactive T cells are part of the normal immune repertoire and therefore have the potential to contribute to the pathogenesis of MS. Given the lack of specificity to MS, OSP-reactive T-cells are unlikely to be solely responsible for the disease process.
Vu
T
T
Department of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095, USA.
Myers
L W
LW
Ellison
G W
GW
Mendoza
F
F
Bronstein
J M
JM
D000328:Adult; D000368:Aged; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D001681:Biological Assay; D002455:Cell Division / Q000187:drug effects* / Q000276:immunology; D057167:Claudins; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism* / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D001324:Autoantigens; C120453:CLDN11 protein, human; D057167:Claudins; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments