title: Gastric surgery is not a risk for Barrett's esophagus or esophageal adenocarcinoma.
abstract: OBJECTIVE
  The contribution of duodeno-gastroesophageal reflux to the development of Barrett's esophagus has remained an interesting but controversial topic. The present study assessed the risk for Barrett's esophagus after partial gastrectomy.
  
  
  METHODS
  The data of outpatients from a medicine and gastroenterology clinic who underwent upper gastrointestinal endoscopy for any reason were analyzed in a case-control study. A case population of 650 patients with short- segment and 366 patients with long-segment Barrett's esophagus was compared in a multivariate logistic regression to a control population of 3047 subjects without Barrett's esophagus or other types of gastroesophageal reflux disease.
  
  
  RESULTS
  In the case population, 25 (4%) patients with short-segment and 15 (4%) patients with long-segment Barrett's esophagus presented with a history of gastric surgery compared with 162 (5%) patients in the control population, yielding an adjusted odds ratio of 0.89 with a 95% confidence interval of 0.54-1.46 for short-segment and an adjusted odds ratio of 0.71 (0.30-1.72) for long-segment Barrett's esophagus. Similar results were obtained in separate analyses of 64 patients with Billroth-1 gastrectomy, 105 patients with Billroth-2 gastrectomy, and 33 patients with vagotomy and pyloroplasty for both short- and long-segment Barrett's esophagus. Caucasian ethnicity, the presence of hiatus hernia, and alcohol consumption were all associated with elevated risks for Barrett's esophagus.
  
  
  CONCLUSIONS
  Gastric surgery for benign peptic ulcer disease is not a risk factor for either short- or long-segment Barrett's esophagus. This lack of association between gastric surgery and Barrett's esophagus suggests that reflux of bile without acid is not sufficient to damage the esophageal mucosa.
authors.affiliation: Gastroenterology Section, Department of Veterans Affairs Medical Center, 1501 San Pedro Drive SE, Albuquerque, New Mexico 87108, USA.
authors.forename: B
authors.initials: B
authors.lastname: Avidan
authors.forename: A
authors.initials: A
authors.lastname: Sonnenberg
authors.forename: T G
authors.initials: TG
authors.lastname: Schnell
authors.forename: S J
authors.initials: SJ
authors.lastname: Sontag
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D000368:Aged; D001471:Barrett Esophagus / Q000209:etiology*; D004938:Esophageal Neoplasms / Q000209:etiology*; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors