title: Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.
abstract: The contribution of individual Fcgamma receptor (FcgammaR) subclasses to meningococcal phagocytosis was studied. In addition, functional FcgammaR polymorphisms were determined in 50 patients with meningococcal disease (MD), in 183 first-degree relatives of MD patients, and in 239 healthy control subjects, to study the association of FcgammaR genotypes with disease. Efficient internalization of opsonized Neisseria meningitidis serogroup B was mediated via multiple FcgammaR subclasses on phagocytes. Accordingly, a low-efficiency combination of FcgammaRIIa-R/R131, FcgammaRIIIa-F/F158, and FcgammaRIIIb-NA2/2 genotypes was increased significantly in relatives of patients with MD, compared with healthy control subjects (P<.05; odds ratio, 2.6; 95% confidence interval, 1.1-6.3). FcgammaRIIa and FcgammaRIIIa genotype distributions differed between patients with sepsis and those with meningitis. Combined genotypes of FcgammaRIIa and interleukin-10 -1082, which was previously reported as being associated with MD outcome, were distributed randomly in control subjects but not in relatives of patients with MD (P<.01). These data provide further evidence for the association of polymorphic genes on chromosome 1 and MD.
authors.affiliation: University Medical Center, Dept. of Immunology, Laboratory for Immunotherapy, 3584 EA Utrecht, The Netherlands. L.vdPol@lab.azu.nl
authors.forename: W L
authors.initials: WL
authors.lastname: van der Pol
authors.forename: T W
authors.initials: TW
authors.lastname: Huizinga
authors.forename: G
authors.initials: G
authors.lastname: Vidarsson
authors.forename: M W
authors.initials: MW
authors.lastname: van der Linden
authors.forename: M D
authors.initials: MD
authors.lastname: Jansen
authors.forename: V
authors.initials: V
authors.lastname: Keijsers
authors.forename: F G
authors.initials: FG
authors.lastname: de Straat
authors.forename: N A
authors.initials: NA
authors.lastname: Westerdaal
authors.forename: J G
authors.initials: JG
authors.lastname: de Winkel
authors.forename: R G
authors.initials: RG
authors.lastname: Westendorp
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D005838:Genotype; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008589:Meningococcal Infections / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D009345:Neisseria meningitidis / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics* / Q000378:metabolism
chemical_list: D017452:Receptors, IgG; D016753:Interleukin-10