title: The value of curettage in diagnosis of endometrial hyperplasia.
abstract: OBJECTIVE
  The aim of this study was to assess the value of diagnosis of endometrial hyperplasia by curettage and to determine the results of proliferating cell nuclear antigen (PCNA) immunostaining in differentiating endometrial carcinoma from endometrial hyperplasia.
  
  
  METHODS
  According to Kurman's criteria, we treated 150 patients with endometrial hyperplasia detected by curettage and compared retrospectively the diagnosis by curettage with that by hysterectomy. PCNA expression was examined using immunohistochemostaining on 60 patients with complex atypical hyperplasia detected by curettage.
  
  
  RESULTS
  Simple hyperplasia was found by curettage in 53 patients, complex hyperplasia in 11, simple atypical hyperplasia in 26, and complex atypical hyperplasia in 60. All patients were rediagnosed after hysterectomy. As a result, 65 were found to have simple hyperplasia, 7 complex hyperplasia, 15 simple atypical hyperplasia, 29 complex atypical hyperplasia, and 34 endometrial carcinoma. The accuracy of histological diagnosis by curettage was 76.7-92.0% and was dependent on different types of hyperplasia. Simple atypical hyperplasia and complex atypical hyperplasia were more likely to coexist with endometrial carcinoma than both simple hyperplasia and complex hyperplasia (chi2 = 26.3, P < 0.001), and complex atypical hyperplasia was more likely to coexist with endometrial carcinoma than simple atypical hyperplasia (chi2 = 9.78, P < 0.005). In complex atypical hyperplasia patients, coexistence with endometrial carcinoma was more common after menopause than before menopause (chi2 = 3.93, P < 0.05). In complex atypical hyperplasia patients, the expression of PCNA in cases associated with endometrial carcinoma was higher or stronger than in cases associated without endometrial carcinoma (chi2 = 7.68, P < 0.01, or U = 252.00, P < 0.01). Conclusions. Curettage tends to be more highly accurate in diagnosing simple hyperplasia than complex atypical hyperplasia, which is often found by hysterectomy to be associated with endometrial carcinoma. The expression of PCNA may be helpful in differentiating complex atypical hyperplasia from endometrial carcinoma.
authors.affiliation: Department of Gynecologic Oncology, Women's Hospital, School of Medcine, Zhejiang University, Hangzhou, 310006, China. xiex@mail.hz.zj.cn
authors.forename: Xing
authors.initials: X
authors.lastname: Xie
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Lu
authors.forename: Da-Feng
authors.initials: DF
authors.lastname: Ye
authors.forename: Huai-Zeng
authors.initials: HZ
authors.lastname: Chen
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Fu
mesh_terms: D000328:Adult; D000368:Aged; D003475:Curettage; D004714:Endometrial Hyperplasia / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012680:Sensitivity and Specificity
chemical_list: D018809:Proliferating Cell Nuclear Antigen