title: Withdrawal from nicotine facilitates diazepam binding inhibitor mRNA expression in mouse cerebral cortex.
abstract: Changes in diazepam binding inhibitor (DBI) mRNA expression after withdrawal from nicotine were examined. Withdrawal from nicotine Increased DBI mRNA expression in cerebral cortices derived from nicotine-dependent mice and in the neurons continuously exposed to nicotine (0.1 microM). These results indicate that withdrawal from nicotine after its long-term exposure induces steep increase of DBI mRNA expression as reported previously in ethanol- and morphine-dependent animals.
authors.affiliation: Department of Pharmacology, Kawasaki Medical School, Kurashiki 701-0192, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Katsura
authors.forename: K
authors.initials: K
authors.lastname: Shuto
authors.forename: Y
authors.initials: Y
authors.lastname: Mohri
authors.forename: A
authors.initials: A
authors.lastname: Tsujimura
authors.forename: S
authors.initials: S
authors.lastname: Ohkuma
mesh_terms: D000818:Animals; D001007:Anxiety / Q000503:physiopathology; D002540:Cerebral Cortex / Q000502:physiology*; D026261:Diazepam Binding Inhibitor / Q000378:metabolism*; D015870:Gene Expression / Q000187:drug effects; D051379:Mice; D009538:Nicotine / Q000494:pharmacology; D018722:Nicotinic Agonists / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000235:genetics; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D014029:Tobacco Use Disorder / Q000503:physiopathology*
chemical_list: D026261:Diazepam Binding Inhibitor; D018722:Nicotinic Agonists; D012333:RNA, Messenger; D011978:Receptors, Nicotinic; D009538:Nicotine