Gamma Knife radiosurgery as a primary surgical treatment for hypersecreting pituitary adenomas.
OBJECTIVE
To estimate the efficacy of Gamma Knife radiosurgery (GKR) especially as a primary surgical treatment for hypersecreting pituitary adenomas.


METHODS
274 patients were treated with GKR. The mean tumor volume was 1.86 cm(3). The mean peripheral dose was 28.7 Gy.


RESULTS
223 patients were followed up for an average of 31.6 months. The dose related to the tumor growth control and endocrinological normalization was detailed and statistical analysis of the data was performed.


CONCLUSIONS
GKR as a primary surgical treatment for hypersecreting pituitary adenomas may be safe and effective.
Zhang
N
N
Department of Neurosurgery, Hua Shan Hospital & Shanghai Gamma Knife Hospital, Shanghai, China. nanzhang@sina.com
Pan
L
L
Dai
J
J
Wang
B
B
Wang
E
E
Zhang
W
W
Cai
P
P
D000236:Adenoma / Q000378:metabolism / Q000601:surgery*; D000239:Adenoma, Acidophil / Q000378:metabolism / Q000601:surgery; D000237:Adenoma, Basophil / Q000378:metabolism / Q000601:surgery; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D000368:Aged; D001971:Bromocriptine / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D006966:Hyperprolactinemia / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D007247:Infertility, Female / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010907:Pituitary Hormones / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011388:Prolactin / Q000378:metabolism; D015175:Prolactinoma / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery; D016634:Radiosurgery; D012449:Safety; D016896:Treatment Outcome
D010907:Pituitary Hormones; D019382:Human Growth Hormone; D001971:Bromocriptine; D000324:Adrenocorticotropic Hormone; D011388:Prolactin