Experimental studies on the antiviral agent famciclovir in Behçet's disease symptoms in ICR mice.
BACKGROUND
Chronic oral aphthae, recurrent genital ulcers and uveitis are the three main manifestations of Behçet's disease (BD). The aetiopathogenesis of BD is still obscure, but herpes simplex virus (HSV) is one of the possible causal factors. Various kinds of drugs, including immunosuppressants and aciclovir have been used in treatment, but effectiveness is variable.


OBJECTIVE
To demonstrate the efficacy of famciclovir, an antiviral compound that acts against HSV, varicella-zoster virus and hepatitis B virus, in a murine model of BD.


METHODS
Using the HSV-induced BD mouse model, famciclovir was administered variously before and after inoculation or from the day of lesion occurrence, with appropriate controls. Ulceration of the mouth and genital skin and eye involvement were monitored. In addition, spleen cytokine expression was measured by polymerase chain reaction.


RESULTS
Pretreatment and concurrent treatment did not affect the occurrence of BD, but treatment from the appearance of lesions was effective in improving BD and preventing recurrence. After famciclovir, interleukin 2 expression correlated with the recurrence of BD symptoms.


CONCLUSIONS
This model suggests the possible role of immune response to viral infection in the development and activation of BD. The study provides a rationale for clinical trials of famciclovir in the human form of BD.
Sohn
S
S
Laboratory of Cell Biology, Ajou University Institute for Medical Sciences, Suwon 442-721, Korea. sohnsh@madang.ajou.ac.kr
Bang
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D
Lee
E S
ES
Kwon
H J
HJ
Lee
S I
SI
Lee
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D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001528:Behcet Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D004195:Disease Models, Animal; D000077595:Famciclovir; D006561:Herpes Simplex / Q000150:complications / Q000188:drug therapy; D007376:Interleukin-2 / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D011355:Prodrugs / Q000627:therapeutic use*; D012008:Recurrence; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000998:Antiviral Agents; D007376:Interleukin-2; D011355:Prodrugs; D015075:2-Aminopurine; D000077595:Famciclovir