Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro.
The effects of retinoic acid (RA) on cell replication, fibronectin and laminin synthesis, integrin expression and haptotactic migration of three mesothelioma cell cultures of different histotype, one epithelioid, one fibromatous and one biphasic, were evaluated. Cell growth was not affected by RA, while RA treatment decreased the synthesis of fibronectin and laminin and inhibited the migration of all three mesotheliomas on substrates of fibronectin and laminin; on the contrary, the expression of some integrins was not significantly modified by RA. These data indicate that RA may lead to a decrease of mesothelioma cell local invasion; this can correlate with a modification induced by RA on mesothelioma tumor progression in vivo.
Scarpa
Susanna
S
Dipartimento Medicina Sperimentale e Patologia, I-00161 Roma, Italy. Susanna.Scarpa@uniroma1.it
Giuffrida
Anna
A
Palumbo
Camilla
C
Coletti
Anna
A
Cerrito
Maria Grazia
MG
Vasaturo
Fortunata
F
Sinibaldi
Paola
P
Simonelli
Lucilla
L
Procopio
Antonio
A
Modesti
Andrea
A
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D015622:Epithelioid Cells / Q000378:metabolism; D005353:Fibronectins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D006801:Humans; D007797:Laminin / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008654:Mesothelioma / Q000378:metabolism / Q000473:pathology*; D010997:Pleural Neoplasms / Q000378:metabolism / Q000473:pathology*; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D005353:Fibronectins; D007797:Laminin; D014212:Tretinoin