Informative value of monitoring of immune status and genome expression in blood leukocytes in psoriatic patients.
Comparative analysis of association with psoriasis before and after treatment of 53K/H2A and 43K/H2A leukocyte protein markers and parameters of leukocyte population (18 indexes) including concentration of peripheral blood lymphocyte subpopulations as markers of the immune status revealed advantages of the former method of patient monitoring for the evaluation of treatment efficacy. The method showed 100% sensitivity and correlation with the dynamics of clinical symptoms. A significant correlation of 53K/H2A parameter with blood content of CD3+, CD4+, CD8+, and CD72+ lymphocytes was established.
Paponov
V D
VD
Medical Genetic Center, Russian Academy of Medical Science, Moscow. v_paponov@mail.ru
Suntsova
I G
IG
Paponov
V V
VV
Baidakova
G V
GV
Mordovtsev
V N
VN
Oparin
R B
RB
Rezaikina
A V
AV
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000096:biosynthesis; D017252:CD3 Complex / Q000096:biosynthesis; D015704:CD4 Antigens / Q000096:biosynthesis; D016827:CD8 Antigens / Q000096:biosynthesis; D002648:Child; D005260:Female; D016678:Genome; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000235:genetics* / Q000276:immunology*
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D017252:CD3 Complex; D015704:CD4 Antigens; C064228:CD72 protein, human; D016827:CD8 Antigens