Eradication of Helicobacter pylori and improvement of hereditary angioneurotic oedema.
Helicobacter pylori infection is thought to be a causal factor in various dermatological disorders. We assessed the frequency of H pylori infection in 65 patients with hereditary angioneurotic oedema. We measured the serum concentration of antibodies against H pylori and did the carbon-14-urease breath test in patients with positive H pylori serology. 19 of 65 patients had H pylori infection. All patients with infection, and 11 of 46 without infection, had a history of recurrent episodes of acute abdominal pain. We successfully eradicated H. pylori infection in 18 patients. The frequency of abdominal symptoms was significantly higher in the infected group (p=0.002 after adjustment for age). In nine of 19 patients with dyspepsia, the frequency of oedematous episodes decreased from 100 over 10 months before eradication to 19 during the 10-month follow-up period. Screening for, and eradication of, H pylori infection seems to be justified in patients with hereditary angioneurotic oedema.
Farkas
H
H
Füst
G
G
Fekete
B
B
Karádi
I
I
Varga
L
L
D015746:Abdominal Pain / Q000209:etiology*; D000328:Adult; D000799:Angioedema / Q000235:genetics* / Q000382:microbiology; D000907:Antibodies, Bacterial / Q000097:blood; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency*; D003613:Danazol / Q000627:therapeutic use; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008297:Male
D000907:Antibodies, Bacterial; D003174:Complement C1 Inactivator Proteins; D004965:Estrogen Antagonists; D003613:Danazol