Two mammalian mitotic aurora kinases: who's who?
Several serine-threonine kinases related to the Ipl1p kinase in budding yeast, termed aurora kinases, have been cloned recently. Their characterization revealed them to be important regulators of mitotic functions, including (i) the separation of the centrosome, (ii) assembly of the spindles, and (iii) segregation of the chromosomes. The Perspective by Descamps and Prigent delves into the latest observations on aurora kinases in humans and the specific roles of each kinase within the process of mitosis.
Descamps
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S
the Groupe Cycle Cellulaire, UMR 6061 Génétique et Développement, CNRS-Université de Rennes I, IFR 97 Génomique Fonctionnelle et Santé, Faculté de Médecine, 2 avenue du Pr Léon Bernard, CS 34317, 35043 Rennes cedex, France. claude.prigent@univ-rennes1.fr
Prigent
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C
D000818:Animals; D064127:Aurora Kinases; D018797:Cell Cycle Proteins / Q000502:physiology; D018385:Centrosome / Q000502:physiology; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D006801:Humans; D018386:Kinetochores / Q000502:physiology; D016200:Maturation-Promoting Factor / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*
D018797:Cell Cycle Proteins; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D016200:Maturation-Promoting Factor