The effects of dietary conjugated nonadecadienoic acid on body composition in mice.
A 19-carbon conjugated diene, conjugated nonadecadienoic acid (CNA), inhibited heparin-releasable lipoprotein lipase and reduced lipid stores in 3T3-L1 adipocytes similarly to conjugated linoleic acid (CLA). When fed to growing mice (0.3% of diet) CNA reduced body fat by 81% whereas CLA reduced body fat by 25%. CLA and CNA differ in length by one carbon atom so they are unlikely to share a common metabolite to account for these observations.
Park
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Food Research Institute, Department of Food Microbiology and Toxicology, University of Wisconsin--Madison, 53706, USA.
Pariza
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MW
D016475:3T3 Cells; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005990:Glycerol / Q000378:metabolism; D007536:Isomerism; D019787:Linoleic Acid / Q000494:pharmacology; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors; D051379:Mice; D008970:Molecular Weight; D014280:Triglycerides / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; D019787:Linoleic Acid; D008071:Lipoprotein Lipase; D005990:Glycerol