title: Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens.
abstract: Elevated levels of immunoglobulin (Ig)E are associated with immediate-type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose-dependently inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti-allergic activity by inhibiting IgE production from B cells.
authors.affiliation: Department of Oriental Pharmacy, College of Pharmacy, Center of Oriental Medicinal Science, Wonkwang University, Sukjang-Dong, 707, Kyung-Ju City, Kyungpook 780-714, South Korea. hmkim@wonkwang.ac.kr
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Won
authors.forename: E J
authors.initials: EJ
authors.lastname: Park
authors.forename: H J
authors.initials: HJ
authors.lastname: Chae
authors.forename: H R
authors.initials: HR
authors.lastname: Kim
authors.forename: C H
authors.initials: CH
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Baek
mesh_terms: D000707:Anaphylaxis / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D019659:Asteraceae; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051379:Mice; D008813:Mice, Inbred ICR; D010047:Ovalbumin; D037342:Pertussis Toxin; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D010566:Virulence Factors, Bordetella
chemical_list: D010936:Plant Extracts; D010566:Virulence Factors, Bordetella; D007073:Immunoglobulin E; D010047:Ovalbumin; D037342:Pertussis Toxin