title: Maxillary brown tumor in secondary hyperparathyroidism requiring urgent parathyroidectomy.
abstract: Brown tumors are unusual but serious complications of renal osteodystrophy, and can be successfully treated by parathyroidectomy or by pharmacological treatment of hyperparathyroidism. Brown tumors in patients with severe hyperparathyroidism (HPT) secondary to renal failure have been increasingly reported. We describe an unusual case of brown tumors at the maxillary bone and the seventh right rib, in a 57-year old man with a long history of hemodialysis. The maxillary lesion caused serious local discomfort due to its rapid growth. In this setting, surgical total parathyroidectomy was chosen as the most adequate therapeutic approach, given the previous unsatisfactory response to calcitriol. After successful parathyroidectomy, rapid healing was achieved with sclerosis of both brown tumors, as documented by serial computerized tomograms. In conclusion, although vitamin D therapy has been beneficial in several cases of secondary hyperparathyroidism complicated by brown tumors, we propose that whenever regression of the tumor bulk is urgently needed, as in our case, parathyroidectomy should be the first treatment choice.
authors.affiliation: Department of Internal Medicine and Public Medicine, University of Bari, Polyclinic, Italy. lfmorrone@wappi.com
authors.forename: L F
authors.initials: LF
authors.lastname: Morrone
authors.forename: G C
authors.initials: GC
authors.lastname: Ettorre
authors.forename: G
authors.initials: G
authors.lastname: Passavanti
authors.forename: M
authors.initials: M
authors.lastname: Tampoia
authors.forename: P
authors.initials: P
authors.lastname: Schiavone
authors.forename: P
authors.initials: P
authors.lastname: Coratelli
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000209:etiology; D006101:Granuloma, Giant Cell / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008441:Maxillary Neoplasms / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D006435:Renal Dialysis; D012272:Ribs / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D010281:Parathyroid Hormone