title: Stem cells. PTEN--coupling tumor suppression to stem cells?
authors.affiliation: Amgen Research Institute, Toronto, Ontario M5G 2C1, Canada. jpenning@amgen.com
authors.forename: J M
authors.initials: JM
authors.lastname: Penninger
authors.forename: J
authors.initials: J
authors.lastname: Woodgett
mesh_terms: D000818:Animals; D019521:Body Patterning; D001921:Brain / Q000002:abnormalities / Q000196:embryology / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology; D002452:Cell Count; D002454:Cell Differentiation; D002455:Cell Division; D048429:Cell Size; D002471:Cell Transformation, Neoplastic; D004622:Embryo, Mammalian / Q000166:cytology; D018390:Gene Targeting; D016147:Genes, Tumor Suppressor; D018095:Germ-Line Mutation; D006801:Humans; D019656:Loss of Heterozygosity; D051379:Mice; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D009474:Neurons / Q000166:cytology*; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics* / Q000502:physiology*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology*; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000502:physiology*
chemical_list: D018129:Phosphatidylinositol Phosphates; D025521:Tumor Suppressor Proteins; C060974:phosphatidylinositol 3,4,5-triphosphate; D019869:Phosphatidylinositol 3-Kinases; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human