title: Health-related quality of life in type 1 diabetic patients and influence of peripheral nerve involvement.
abstract: We examined the relationships between diabetic peripheral nerve involvement and patients' own perception of quality of life in a multidimensional study based on outcome research recommendations. The study enrolled 50 consecutive outpatients with type 1 diabetes mellitus (23 men, 27 women; mean age, 40.1 years). The patients were evaluated with validated clinical tests (e. g. Semmes-Weinstein, vibration perception threshold, muscle strength), neurophysiological tests (sural, peroneal and ulnar nerves) and patient-oriented (SF-36 and NASS) questionnaires. Patient-oriented physical scores were significantly related with: (1) neurophysiological findings of the lower limbs; (2) conventional measurements of sensitivity. Conversely, patient-oriented mental scores were not related with these findings. The patient-oriented questionnaires provided an important perspective of the severity of the disease, often closely related with the biological parameters. They offered new interpretations to conventional biological measurements. In particular, the peripheral nerve picture was strictly related to the physical aspects of the patients' quality of life, and not with the mental aspects.
authors.affiliation: Institute of Neurology, Catholic University, Largo F. Vito 1, I-00168 Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Padua
authors.forename: C
authors.initials: C
authors.lastname: Saponara
authors.forename: G
authors.initials: G
authors.lastname: Ghirlanda
authors.forename: I
authors.initials: I
authors.lastname: Aprile
authors.forename: R
authors.initials: R
authors.lastname: Padua
authors.forename: F
authors.initials: F
authors.lastname: Pauri
authors.forename: P
authors.initials: P
authors.lastname: Tonali
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology* / Q000523:psychology*; D003929:Diabetic Neuropathies / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D017060:Patient Satisfaction; D010543:Peroneal Nerve / Q000502:physiology; D011788:Quality of Life; D012720:Severity of Illness Index; D013497:Sural Nerve / Q000502:physiology