title: Actin nucleation: nucleation-promoting factors are not all equal.
abstract: Arp2/3 complex plays a key role in regulated actin polymerization. A recent study has revealed marked differences in the ability of two nucleation-promoting factors - N-WASP and Scar/WAVE1 - to activate the Arp2/3 complex. Further insights have come from determination of the Arp2/3 crystal structure.
authors.affiliation: Department of Biochemistry, 413 Vail Building, HB 7200, Dartmouth Medical School, Hanover, New Hampshire 03755-3844, USA. Henry.Higgs@Dartmouth.edu
authors.forename: H N
authors.initials: HN
authors.lastname: Higgs
mesh_terms: D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D001704:Biopolymers; D003598:Cytoskeletal Proteins
chemical_list: D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins; D001704:Biopolymers; D003598:Cytoskeletal Proteins