title: Functional promoter variants of highly conserved inducible hsp70 genes significantly affect stress response.
abstract: Promoter variants differing in potential cis-acting elements and showing impaired binding of corresponding transcription factors are described in the inducible porcine hsp70.2 gene (GC box; initiator-like region, InR) and in its bovine homologue (AP2 site), respectively. Interestingly, all these promoter variants are stable established in the analysed populations in spite of significant negative effects on transcriptional activity and indications of not neutral behaviour in response to breeding selection. Moreover, in pigs they are likely to be evolutionary fixed as suggested by their presence in recent breeds and in wild boars as well. Compensation of the effect of the observed 'down'-mutations by further yet unknown gene variants is assumed.
authors.affiliation: Department of Molecular Biology, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany. schwerin@fbn-dummerstorf.de
authors.forename: M
authors.initials: M
authors.lastname: Schwerin
authors.forename: S
authors.initials: S
authors.lastname: Maak
authors.forename: C
authors.initials: C
authors.lastname: Kalbe
authors.forename: R
authors.initials: R
authors.lastname: Fuerbass
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002478:Cells, Cultured; D017930:Genes, Reporter; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006358:Hot Temperature; D007763:Lac Operon; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D013552:Swine
chemical_list: D018840:HSP70 Heat-Shock Proteins