Occult choroidal neovascularization in adult-onset foveomacular vitelliform dystrophy.
OBJECTIVE
To report 6 cases in which indocyanine green angiography (ICGA) failed to convert occult choroidal neovascularization (CNV) into well-defined CNV in adult-onset foveomacular vitelliform dystrophy (AOFVD).


METHODS
Patients with AOFVD observed from 1993 to 1999 were prospectively followed up. Whenever the development of CNV was suspected, ICGA was performed to detect the precise location and extension of CNV by means of the IMAGEnet System.


RESULTS
Six out of 51 patients (11.7%) developed CNV during the follow-up. The CNV was of the occult type, with an associated detachment of the pigment epithelium in 1 eye. On ICGA, a large hyperfluorescent lesion appeared after about 10 min, irregularly increasing with time, without a clear visualization of site and extension of CNV.


CONCLUSIONS
In AOFVD, ICGA may fail to convert occult CNV into well-defined CNV, which is amenable to laser treatment, since hyperfluorescence caused by the probably vitelliform material binding to the ICG molecule and the CNV-induced hyperfluorescence cannot be angiographically distinguished from each other.
Da Pozzo
S
S
Eye Clinic, University of Trieste, Italy.
Parodi
M B
MB
Toto
L
L
Ravalico
G
G
D000368:Aged; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D011446:Prospective Studies; D012164:Retinal Diseases / Q000150:complications* / Q000175:diagnosis
D007208:Indocyanine Green