No significant increase in chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with spiramycin.
In this study, the chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) were investigated in human lymphocytes treated with spiramycin antibiotic (trade name, rovamycin). Spiramycin did not induce the CAs and SCEs, and also did not decrease the mitotic index (MI). However, spiramycin decreased the replication index (RI) only at 48 h treatment times.
Rencüzoğullari
Eyyüp
E
Cukurova University, Faculty of Arts and Sciences, Biology Department, Adana, Turkey.
Ila
Hasan Basri
HB
Topaktaş
Mehmet
M
Kayraldiz
Ahmet
A
Budak
Songül
S
Arslan
Mehmet
M
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D002869:Chromosome Aberrations / Q000187:drug effects*; D002877:Chromosomes, Human / Q000187:drug effects* / Q000648:ultrastructure; D003582:Cytogenetics; D004261:DNA Replication / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008940:Mitotic Index; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D015572:Spiramycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D015572:Spiramycin