title: [Chronic colonic pseudo-obstruction secondary to neuroleptics].
abstract: Colonic pseudo-obstruction is characterized by non-mechanical chronic colonic dilatation. It is an infrequent entity that can be provoked by multiple causes, among them pharmacological. We present the case of a 74-year-old female psychiatric patient who presented abdominal bloating, diarrhea, intense electrolytic alterations and marked radiographic colonic dilatation after treatment with a neuroleptic (zuclopenthixol decanoate). Organic obstruction and other causes were ruled out and the final diagnosis was chronic colonic pseudo-obstruction secondary to the use of neuroleptics. Cisapride (20 mg/8 h) produced a slight improvement in symptoms but colonic dilatation was permanent.
authors.affiliation: Servicio de Medicina Digestiva, Hospital Universitario La Fe, Valencia, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Benlloch
authors.forename: F
authors.initials: F
authors.lastname: Pérez-Aguilar
authors.forename: J
authors.initials: J
authors.lastname: Ponce
authors.forename: J
authors.initials: J
authors.lastname: Berenguer
mesh_terms: D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003006:Clopenthixol / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003112:Colonic Pseudo-Obstruction / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans
chemical_list: D014150:Antipsychotic Agents; C029674:clopenthixol decanoate; D003006:Clopenthixol