STK receptor tyrosine kinase regulates susceptibility to infection with Listeria monocytogenes.
We have previously identified the STK receptor tyrosine kinase as a key regulator of macrophage activation and cell-mediated immune responses. Here we demonstrate that, although MSP activation of STK inhibits NO production by macrophages in response to heat-killed Listeria monocytogenes, STK-deficient mice exhibit increased susceptibility to infection with Listeria.
Lutz
Michael A
MA
Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802-3500, USA.
Gervais
Francine
F
Bernstein
Alan
A
Hattel
Arthur L
AL
Correll
Pamela H
PH
D000818:Animals; D002478:Cells, Cultured; D004198:Disease Susceptibility; D006133:Growth Substances / Q000494:pharmacology; D017228:Hepatocyte Growth Factor; D007371:Interferon-gamma / Q000494:pharmacology; D008089:Listeria monocytogenes / Q000378:metabolism / Q000472:pathogenicity; D008088:Listeriosis / Q000201:enzymology* / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000187:drug effects; D051379:Mice; D018345:Mice, Knockout; D009569:Nitric Oxide / Q000096:biosynthesis; D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D013154:Spleen / Q000382:microbiology
D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; C082332:macrophage stimulating protein; D009569:Nitric Oxide; D017228:Hepatocyte Growth Factor; D007371:Interferon-gamma; C080835:RON protein; D020794:Receptor Protein-Tyrosine Kinases