Acute polyosteal osteomyelitis in a patient with congenital ichthyosis and acute lymphoblastic leukemia.
Osteomyelitis can develop after bacteremia in children and is a rare complication of chemotherapy for acute lymphoblastic leukemia. A child with congenital ichthyosis, acute lymphoblastic leukemia and multifocal hematogenous osteomyelitis is described herein. A breached skin barrier secondary to ichthyosis during induction chemotherapy, coupled with impaired immunity, likely provided the opportunity for bacterial seeding, leading to an extensive multifocal osteomyelitis.
Tolar
J
J
Department of Pediatrics, University of Minnesota, St. Paul, MN, USA.
Kravitz
G
G
Walker
K
K
Moertel
C L
CL
D016470:Bacteremia / Q000150:complications*; D002648:Child; D006801:Humans; D016113:Ichthyosiform Erythroderma, Congenital / Q000150:complications*; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D011859:Radiography