title: ST depression in ECG at entry indicates severe coronary lesions and large benefits of an early invasive treatment strategy in unstable coronary artery disease; the FRISC II ECG substudy. The Fast Revascularisation during InStability in Coronary artery disease.
abstract: BACKGROUND
  In unstable coronary artery disease, ST-segment depression indicates a poor prognosis. We evaluated whether the effect of early revascularization and the extent of coronary lesions were related to ST-segment and T wave changes on admission.
  
  
  RESULTS
  2457 patients with unstable coronary artery disease were randomized to an early invasive strategy with coronary angiography/revascularization within 7 days or to a non-invasive strategy with coronary procedures only when symptoms or severe ischaemia recurred. ST depression was present in 1114 (45.5%) patients. In the invasive group, 45% of the patients with ST depression had three-vessel disease or left main stenosis compared with 22% if no ST-segment depression was present, PP=0.004 while mortality was changed from 5.8 to 3.3%, P=0.050. In patients without ST-segment depression the corresponding rates concerning death/myocardial infarction were 10.4 and 8.9, and for mortality 2.0 and 1.2% (non-significant).
  
  
  CONCLUSIONS
  In unstable coronary artery disease, ST-segment depression is associated with a 100% increase in the occurrence of three-vessel/left main disease and to an increased risk of subsequent cardiac events. In these patients an early invasive strategy substantially decreases death/myocardial infarction.
authors.affiliation: Department of Cardiology, University Hospital, Uppsala, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Diderholm
authors.forename: B
authors.initials: B
authors.lastname: Andrén
authors.forename: G
authors.initials: G
authors.lastname: Frostfeldt
authors.forename: M
authors.initials: M
authors.lastname: Genberg
authors.forename: T
authors.initials: T
authors.lastname: Jernberg
authors.forename: B
authors.initials: B
authors.lastname: Lagerqvist
authors.forename: B
authors.initials: B
authors.lastname: Lindahl
authors.forename: L
authors.initials: L
authors.lastname: Wallentin
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D023921:Coronary Stenosis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D004562:Electrocardiography; D023381:Endpoint Determination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010343:Patient Admission; D011379:Prognosis; D012720:Severity of Illness Index; D013548:Sweden / Q000453:epidemiology; D016896:Treatment Outcome