Aglacins A-D, first representatives of a new class of aryltetralin cyclic ether lignans from Aglaia cordata.
Four new metabolites, aglacins A-D (1-4), were identified from the methanol extract of the stem bark of Aglaia cordata. These compounds represent a new class of aryltetralin cyclic ether lignan. The structure of aglacin A (1) including the absolute configuration was elucidated by interpretation of spectral data, X-ray crystal structure determination, and employing the modified Mosher's method. In addition, three other derivatives, aglacins B-D (2-4), were isolated and identified by spectral means.
Wang
B G
BG
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.
Ebel
R
R
Nugroho
B W
BW
Prijono
D
D
Frank
W
W
Steube
K G
KG
Hao
X J
XJ
Proksch
P
P
D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004988:Ethers, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007214:Indonesia; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D029582:Meliaceae / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004988:Ethers, Cyclic; D017705:Lignans