title: HIV: master of the host cell.
abstract: The human immunodeficiency virus has evolved various mechanisms to exploit its host cells, including the interruption and augmentation of signal transduction pathways. Recently, two DNA microarray studies have illustrated a remarkably broad-based perturbation in host transcriptional responses, which is in part mediated by the HIV-encoded Nef protein. HIV therefore seems to function as a 'master regulator' of cellular gene expression.
authors.affiliation: Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA. littman@saturn.med.nyu.edu
authors.forename: C W
authors.initials: CW
authors.lastname: Arendt
authors.forename: D R
authors.initials: DR
authors.lastname: Littman
mesh_terms: D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000502:physiology*; D015693:Gene Products, nef / Q000502:physiology; D006678:HIV / Q000502:physiology*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology / Q000821:virology*; D054311:nef Gene Products, Human Immunodeficiency Virus
chemical_list: D015693:Gene Products, nef; D054311:nef Gene Products, Human Immunodeficiency Virus