PharmGKB: the Pharmacogenetics Knowledge Base.
The Pharmacogenetics Knowledge Base (PharmGKB; http://www.pharmgkb.org/) contains genomic, phenotype and clinical information collected from ongoing pharmacogenetic studies. Tools to browse, query, download, submit, edit and process the information are available to registered research network members. A subset of the tools is publicly available. PharmGKB currently contains over 150 genes under study, 14 Coriell populations and a large ontology of pharmacogenetics concepts. The pharmacogenetic concepts and the experimental data are interconnected by a set of relations to form a knowledge base of information for pharmacogenetic researchers. The information in PharmGKB, and its associated tools for processing that information, are tailored for leading-edge pharmacogenetics research. The PharmGKB project was initiated in April 2000 and the first version of the knowledge base went online in February 2001.
Hewett
Micheal
M
Stanford Medical Informatics, 251 Campus Drive, MSOB X-215, Stanford, CA 94305-5479, USA. hewett@smi.stanford.edu
Oliver
Diane E
DE
Rubin
Daniel L
DL
Easton
Katrina L
KL
Stuart
Joshua M
JM
Altman
Russ B
RB
Klein
Teri E
TE
D001711:Biotransformation / Q000235:genetics*; D003628:Database Management Systems; D016208:Databases, Factual; D004358:Drug Therapy; D004798:Enzymes / Q000378:metabolism; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010597:Pharmacogenetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D014584:User-Computer Interface
D004798:Enzymes; D004364:Pharmaceutical Preparations