title: Thrombolytic therapy of a left-sided prosthetic valve thrombosis without hemodynamic obstruction: a case report.
abstract: We report a case of a 38-year-old woman with a prosthetic mitral valve who presented with multiple embolic events. Transesophageal echocardiography was used to diagnose nonobstructive thrombi on the prosthetic valve. She underwent successful thrombolytic therapy. The patient was discovered to be in a hypercoagulable state, which probably was caused by the concomitant use of phenytoin. We review the literature for diagnosis and treatment of nonobstructive prosthetic valve thrombosis.
authors.affiliation: University of Chicago, Division of Cardiology, Department of Medicine, Illinois 60637, USA.
authors.forename: M
authors.initials: M
authors.lastname: Gulati
authors.forename: K
authors.initials: K
authors.lastname: Furlong
authors.forename: J
authors.initials: J
authors.lastname: DeCara
authors.forename: K T
authors.initials: KT
authors.lastname: Spencer
authors.forename: R M
authors.initials: RM
authors.lastname: Lang
mesh_terms: D000328:Adult; D017548:Echocardiography, Transesophageal; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008943:Mitral Valve / Q000601:surgery*; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase