The Histone Database.
Histone proteins are often noted for their high degree of sequence conservation. It is less often recognized that the histones are a heterogeneous protein family. Furthermore, several classes of non-histone proteins containing the histone fold motif exist. Novel histone and histone fold protein sequences continue to be added to public databases every year. The Histone Database (http://genome.nhgri.nih.gov/histones/) is a searchable, periodically updated collection of histone fold-containing sequences derived from sequence-similarity searches of public databases. Sequence sets are presented in redundant and non-redundant FASTA form, hotlinked to GenBank sequence files. Partial sequences are also now included in the database, which has considerably augmented its taxonomic coverage. Annotated alignments of full-length non-redundant sets of sequences are now available in both web-viewable (HTML) and downloadable (PDF) formats. The database also provides summaries of current information on solved histone fold structures, post-translational modifications of histones, and the human histone gene complement.
Sullivan
Steven
S
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 45, Room 6AN12J, 45 Center Drive, MSC 6510, Bethesda, MD 20892-6510, USA.
Sink
Daniel W
DW
Trout
Kenneth L
KL
Makalowska
Izabela
I
Taylor
Patrick M
PM
Baxevanis
Andreas D
AD
Landsman
David
D
D020816:Amino Acid Motifs; D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000235:genetics; D030562:Databases, Protein; D014644:Genetic Variation; D006657:Histones / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D016415:Sequence Alignment; D017385:Sequence Homology
D002868:Chromosomal Proteins, Non-Histone; D006657:Histones