In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds.
Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active beta-lactams (MICs at which 50% of the strains are inhibited [MIC(50)s], 0.125 to 0.25 microg/ml; MIC(90)s, 1.0 to 2.0 microg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other beta-lactams were similar to those of ertapenem.
Hoellman
Dianne B
DB
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
Kelly
Linda M
LM
Credito
Kim
K
Anthony
Lauren
L
Ednie
Lois M
LM
Jacobs
Michael R
MR
Appelbaum
Peter C
PC
D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification; D015780:Carbapenems / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology
D015780:Carbapenems; D002511:Cephalosporins; C108047:L 749345; D013845:Thienamycins; D015378:Imipenem; D002443:Ceftriaxone; D000077731:Meropenem