Gene array technology to determine host responses to Salmonella.
Gene expression array technology is a powerful new tool that has already been used to expand our understanding of host-pathogen interactions. There has been a rapid increase in published reports describing use of this approach to profile host responses to pathogenic bacteria and viruses. The large number of array studies currently in progress coupled with increasing accessibility of this new technology promises a plethora of gene expression data on host response to infection in the near future. Recent insights into macrophage and epithelial cell responses to Salmonella infection garnered from array studies are outlined and used as a basis to discuss various future research directions using gene arrays that will advance the field of cellular microbiology. There is an exciting potential for the gene expression data generated in such studies to provide insights into host physiology, the pathophysiology of disease and novel therapeutics.
Rosenberger
C M
CM
Biotechnology Laboratory, Department of Microbiology and Immunology, 6174 University Boulevard, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Pollard
A J
AJ
Finlay
B B
BB
D000818:Animals; D002460:Cell Line; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D020869:Gene Expression Profiling; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D012475:Salmonella / Q000472:pathogenicity*; D012480:Salmonella Infections / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology