title: DNA cleavage by aromatic amines.
abstract: A series of aryl amines was found to induce cleavage of DNA. Subsequent refinement led to an efficient family of dimeric derivatives capable of cleavage at low concentration. Initial investigations suggest this is an unprecedented mode of DNA cleavage, which may be ultimately applied to the development of sequence-specific agents.
authors.affiliation: Department of Chemistry, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA. pwarner@lynx.neu.edu
authors.forename: Philip M
authors.initials: PM
authors.lastname: Warner
authors.forename: Jiwei
authors.initials: J
authors.lastname: Qi
authors.forename: Bin
authors.initials: B
authors.lastname: Meng
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Longfei
authors.initials: L
authors.lastname: Xie
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Shafey
authors.forename: Graham B
authors.initials: GB
authors.lastname: Jones
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001435:Bacteriophages / Q000235:genetics; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D004249:DNA Damage; D019281:Dimerization; D006868:Hydrolysis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D000970:Antineoplastic Agents; D004247:DNA