title: Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin.
abstract: We identified two cDNAs coding for the novel human actin-related proteins (Arps) hArpM1 and hArpM2. Both of them show remarkable similarity to conventional actin, and the ATP-binding motif and nuclear-export signals of actin are highly conserved. Their mRNAs are expressed in all tested human tissues, but in smaller amounts than that of actin. These features suggest that hArpM1 and M2 are involved in cytoskeletal organization like other cytoplasmic Arp subfamilies.
authors.affiliation: Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Division of Life Science, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi 1-1, Aoba-ku, 981-8555, Sendai, Japan. mharata@biochem.tohoku.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Harata
authors.forename: K
authors.initials: K
authors.lastname: Nishimori
authors.forename: S
authors.initials: S
authors.lastname: Hatta
mesh_terms: D000199:Actins / Q000737:chemistry / Q000235:genetics*; D000595:Amino Acid Sequence; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000032:analysis*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment
chemical_list: C445675:ACTRT2 protein, human; C445674:ACTRT3 protein, human; D000199:Actins; D018076:DNA, Complementary