title: Transdermal ketoprofen mitigates the severity of postoperative sore throat : [Le kétoprofène transdermique réduit le mal de gorge postopératoire].
abstract: OBJECTIVE
  To evaluate prospectively the incidence and severity of postoperative sore throat in 63 orotracheally intubated patients undergoing general anesthesia for various surgical procedures and to determine whether postoperative sore throat could be attenuated by treatment with the transdermal nonsteroidal anti-inflammatory drug ketoprofen applied on the anterior skin of the neck during operation.
  
  
  METHODS
  Patients were randomly assigned to have treatment with ketoprofen (ketoprofen group) or to have placebo tape treatment (control group). Postoperative analgesia was obtained by continuous epidural infusion of local anesthetics, and no narcotics were administered intraoperatively or postoperatively. All patients were interviewed postoperatively after 12-20 hr using a scoring scale questionnaire. Sore throat was scored as 0=no sore throat, 1=minimal, 2=mild, 3=moderate, 4=severe.
  
  
  RESULTS
  In the control group, 16 of 32 patients had a sore throat. In the ketoprofen group, less patients (ten of 31 patients) had a sore throat (not significant). The severity of sore throat was alleviated significantly in the ketoprofen group (P <0.05).
  
  
  CONCLUSIONS
  This study suggests the pain caused by tracheal intubation is relieved by intraoperative topical use of transdermal ketoprofen.
authors.affiliation: Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ozaki
authors.forename: K
authors.initials: K
authors.lastname: Minami
authors.forename: T
authors.initials: T
authors.lastname: Sata
authors.forename: A
authors.initials: A
authors.lastname: Shigematsu
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000769:Anesthesia, Inhalation; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010612:Pharyngitis / Q000188:drug therapy* / Q000209:etiology*; D011183:Postoperative Complications / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen