Dietary uptake of lycopene protects human cells from singlet oxygen and nitrogen dioxide - ROS components from cigarette smoke.
There is current interest in the health benefits of dietary carotenoids and the possible deleterious effects on certain sub-populations such as smokers. Here we report in vivo protection of human lymphocytes, conferred by dietary supplementation of lycopene rich foods against the reactive oxygen species, NO(2)(*) radical (by electron transfer) and 1(O)(2) (by energy transfer). It was found that a lycopene rich diet, maintained for 14 days, increased the serum lycopene level 10 fold compared to serum obtained after the same period, where a typical western European diet had been consumed. Relative lymphocyte protection factors of 17.6 and 6.3 against NO(2)(*) radical and 1(O)(2), respectively, were obtained, which re-enforce epidemiological data, showing protection against several chronic diseases by tomato lycopene.
Böhm
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Meclinic Berlin, Friedrichstrasse 71, 10117 Berlin, Germany. info@meoclinic.de
Edge
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Burke
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Truscott
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D000975:Antioxidants / Q000378:metabolism*; D002338:Carotenoids / Q000378:metabolism*; D002478:Cells, Cultured; D019587:Dietary Supplements; D006801:Humans; D000077276:Lycopene; D008214:Lymphocytes / Q000378:metabolism; D009585:Nitrogen Dioxide / Q000378:metabolism*; D016877:Oxidants; D017382:Reactive Oxygen Species; D026082:Singlet Oxygen / Q000378:metabolism*; D012907:Smoking / Q000009:adverse effects*; D014026:Nicotiana
D000975:Antioxidants; D016877:Oxidants; D017382:Reactive Oxygen Species; D026082:Singlet Oxygen; D002338:Carotenoids; D009585:Nitrogen Dioxide; D000077276:Lycopene