Kinetics of intravenous L-lactic acid in anaesthetized minipigs under normoxic/normocapnic/normohydrogenaemic conditions.
A mild and transitory increase in L-lactic acid (LAC) levels can be achieved by LAC infusion under normoxic/normocapnic/normohydrogenaemic conditions. This increase is probably sufficient to confer some protection to cholinesterases from inhibition by organophosphates.
Petroianu
G
G
Department of Pharmacology, University of the United Arab Emirates, Alain, UAE. georg.petroianu@uaeu.ac.ae
Kern
N
N
Kaercher
B
B
Rüfer
R
R
D000818:Animals; D019540:Area Under Curve; D002245:Carbon Dioxide / Q000097:blood; D002800:Cholinesterase Inhibitors / Q000009:adverse effects; D006859:Hydrogen / Q000097:blood; D007262:Infusions, Intravenous; D007700:Kinetics; D019344:Lactic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010100:Oxygen / Q000097:blood*; D013552:Swine; D013556:Swine, Miniature / Q000502:physiology*
D002800:Cholinesterase Inhibitors; D002245:Carbon Dioxide; D019344:Lactic Acid; D006859:Hydrogen; D010100:Oxygen