MAP kinases and the regulation of nuclear receptors.
The activity of nuclear receptors or ligand-activated transcription factors can be regulated both positively and negatively by signals transduced through mitogen-activated protein kinase (MAPK) signaling cascades. Kyriakis discusses how cross talk between MAPK signaling and nuclear receptor signaling occurs and the effect this cross talk has on nuclear receptor function.
Kyriakis
J M
JM
Diabetes Research Laboratory, Massachusetts General Hospital East, Charlestown, MA, USA. kyriakis@helix.mgh.harvard.edu
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology; D020929:Mitogen-Activated Protein Kinase Kinases / Q000502:physiology*; D020239:Receptor Cross-Talk / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*
D018160:Receptors, Cytoplasmic and Nuclear; D020929:Mitogen-Activated Protein Kinase Kinases