title: Does oxygen deficit to the cerebral blood flow caused by subdural hematoma and/or increased intracranial pressure affect the variations in auditory evoked potentials in white New Zealand rabbits?
abstract: The experiment entails surgically placing two subarachnoid bolts and a subdural balloon through the skull of white New Zealand rabbits. One bolt is used to raise the intracranial pressure (ICP) by continuously infusing lactated Ringer's solution (LRS) into the subarachnoid space to maintain the desired level of ICPs, and the second bolt is to monitor the ICP. A subdural balloon is inflated with a known volume of LRS to simulate a subdural hematoma condition. Using various levels of ICP and/or different sizes of balloons, auditory evoked potentials (AEPs) were recorded from a rabbit. The results indicate that a major correlation of changes in AEP peak latencies is due to mechanical forces of a mass (inflated balloon simulating a hematoma) on the brain matter rather than increased ICP. The AEP peak latencies are relatively insensitive to an increase in ICP without the simulated intracranial hematoma. This study provides evidence that oxygen deficit to the cerebral blood flow caused by deformation of certain parts of the brain could be identified using AEPs.
authors.affiliation: Division of Electronics and Information Engineering, Chonbuk National University, Chonju, 561-756, South Korea. jjim@moak.chonbuk.ac.kr
authors.forename: Jae Joong
authors.initials: JJ
authors.lastname: Im
authors.forename: Byung Rim
authors.initials: BR
authors.lastname: Park
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006408:Hematoma, Subdural / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D019586:Intracranial Hypertension / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D011817:Rabbits; D011930:Reaction Time / Q000502:physiology