title: c-Mos and cyclin B/cdc2 connections during Xenopus oocyte maturation.
abstract: Fully-grown G2 arrested Xenopus oocytes can be induced to enter and progress into meiotic cell cycle by progesterone stimulation. This process is termed oocyte maturation. An early response to progesterone is the synthesis of the onco-protein c-Mos, defined as the candidate initiator of Xenopus oocyte maturation, which triggers the MAPK cascade, MPF activation and promotes CSF activity. Here we review our current knowledge on the synthesis, activation and functions of c-Mos in connection with MPF activation during maturation. We also discuss our recent results concerning the dispensability of cyclin B degradation in meiosis I-meiosis II transition and the stabilization of c-Mos through its direct phosphorylation by cyclin B/cdc2.
authors.affiliation: Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR 1086, Montpellier, France. castro@crbm-cnrs.mop.fr
authors.forename: A
authors.initials: A
authors.lastname: Castro
authors.forename: M
authors.initials: M
authors.lastname: Peter
authors.forename: T
authors.initials: T
authors.lastname: Lorca
authors.forename: E
authors.initials: E
authors.lastname: Mandart
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D016203:CDC2 Protein Kinase / Q000502:physiology*; D020090:Chromosome Segregation; D019926:Cyclin B / Q000502:physiology*; D004261:DNA Replication; D016258:Genes, mos; D008025:Ligases; D016200:Maturation-Promoting Factor / Q000502:physiology; D008540:Meiosis / Q000502:physiology; D009865:Oocytes / Q000254:growth & development*; D017231:Proto-Oncogene Proteins c-mos / Q000502:physiology*; D043743:Ubiquitin-Protein Ligase Complexes; D014981:Xenopus
chemical_list: D019926:Cyclin B; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D017231:Proto-Oncogene Proteins c-mos; D016203:CDC2 Protein Kinase; D016200:Maturation-Promoting Factor; D008025:Ligases