title: Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis.
abstract: Burkholderia cepacia is a group of organisms that comprises seven genotypically distinct species (B cepacia genomovars I-VII), which are collectively known as the B cepacia complex. Preoperative infection with B cepacia is associated with a poor prognosis in lung transplant recipients with cystic fibrosis. Many centres do not, therefore, offer transplants to these individuals. Our aim was to ascertain whether or not post-transplant mortality is affected by pretransplant genomovar status. We studied archived isolates with PCR-based methods, and recorded excessive mortality in patients infected with B cepacia genomovar III, but not in those infected with other genomovars.
authors.forename: A
authors.initials: A
authors.lastname: De Soyza
authors.forename: A
authors.initials: A
authors.lastname: McDowell
authors.forename: L
authors.initials: L
authors.lastname: Archer
authors.forename: J H
authors.initials: JH
authors.lastname: Dark
authors.forename: S J
authors.initials: SJ
authors.lastname: Elborn
authors.forename: E
authors.initials: E
authors.lastname: Mahenthiralingam
authors.forename: K
authors.initials: K
authors.lastname: Gould
authors.forename: P A
authors.initials: PA
authors.lastname: Corris
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019121:Burkholderia Infections / Q000150:complications* / Q000188:drug therapy; D016956:Burkholderia cepacia / Q000235:genetics*; D002097:C-Reactive Protein / Q000378:metabolism; D003550:Cystic Fibrosis / Q000150:complications* / Q000401:mortality / Q000601:surgery; D016208:Databases, Factual; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D016040:Lung Transplantation; D011379:Prognosis; D015996:Survival Rate
chemical_list: D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein