Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7).
Pseudomonas aeruginosa isolates from an outbreak in Canada were highly resistant to carbapenems and ceftazidime but not piperacillin. They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-specific primers, owing to mismatches in the forward primer.
Gibb
Alan Patrick
AP
Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada T2N 4N1. a.p.gibb@ed.ac.uk
Tribuddharat
Chanwit
C
Moore
Richard A
RA
Louie
Thomas J
TJ
Krulicki
Wally
W
Livermore
David M
DM
Palepou
Marie-France I
MF
Woodford
Neil
N
D000595:Amino Acid Sequence; D002170:Canada / Q000453:epidemiology; D015780:Carbapenems / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology; D004196:Disease Outbreaks; D006801:Humans; D008969:Molecular Sequence Data; D011552:Pseudomonas Infections / Q000453:epidemiology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013095:Spermidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics
D015780:Carbapenems; C108048:FR 160; C409201:beta-lactamase IMP-1; D001618:beta-Lactamases; D013095:Spermidine