[CD1: A new paradigm for antigen presentation].
Molecules of the major histocompatibility complex (MHC) bind protein-derived peptide antigens and present them to T cells. This has been a central dogma in modern immunology, and our appreciation of a variety of cell-mediated immune responses has been based only on this paradigm. However, we now know that T cell recognition also involves non-peptide antigens. Studies over the past several years have established a new paradigm that non-MHC-encoded molecules of the CD1 family mediate presentation of lipid antigens to T cells, and unraveled their significant role in microbial immunity, tumor immunology, and autoimmunity. Identification of a novel pathway for T cell activation mediated by CD1 molecules opens a possibility for new therapeutic strategies, including development of lipid-based vaccines.
Sugita
M
M
Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan. msugita@nms.ac.jp
D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D018949:Antigens, CD1 / Q000235:genetics / Q000502:physiology; D001500:BCG Vaccine; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008055:Lipids / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D009161:Mycobacterium / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000942:Antigens, Bacterial; D018949:Antigens, CD1; D001500:BCG Vaccine; D008055:Lipids