Early thrombolysis inhibits peri-infarct depolarizations in embolic MCA occlusion.
Rats submitted to middle cerebral artery (MCA) clot embolism were treated with tissue plasminogen activator (TPA) 1.5 and 3.5 h post-occlusion. Reperfusion patterns were monitored by measuring cortical laser-Doppler flow; the direct current potential was measured to detect peri-infarct depolarizations (PID), a known mechanism of ischemic injury. TPA treatment induced reperfusion in 58% of treated animals that was delayed by 41 +/- 7 min (mean +/- s.e.m.) from treatment onset. The probability of reperfusion did not differ significantly between the two treatment groups. TPA treatment led to a 3-fold reduced frequency of PID if administered early or if successful reperfusion was observed (each p < 0.001). Early thrombolysis inhibits, but does not block, PID as an important mechanism of ischemic injury in embolic stroke.
Schüler
O G
OG
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians-University, Marchioninistr. 15, D-81377 Munich, Germany.
Plesnila
N
N
Otto
D
D
Baethmann
A J
AJ
Back
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T
D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology; D013181:Cortical Spreading Depression / Q000502:physiology*; D004569:Electroencephalography; D004594:Electrophysiology; D005343:Fibrinolytic Agents / Q000494:pharmacology; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology* / Q000628:therapy*; D017078:Laser-Doppler Flowmetry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000494:pharmacology
D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator