Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infection.
Human immunodeficiency virus type 1 (HIV-1)-infected subjects treated early after infection have preserved HIV-1-specific CD4+ T-cell function. We studied the effect of highly active antiretroviral therapy (HAART) on the frequency of HIV-1-specific CD8+ T cells in patients treated during early (n = 31) or chronic (n = 23) infection. The degree of viral suppression and time of initiation of treatment influenced the magnitude of the CD8+ T-cell response. HIV-1-specific CD8+ T cells can increase in number after HAART in subjects treated early after infection who have episodes of transient viremia.
Ortiz
Gabriel M
GM
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA. gortiz@gladstone.ucsf.edu
Hu
Jennifer
J
Goldwitz
Joshua A
JA
Chandwani
Rohit
R
Larsson
Marie
M
Bhardwaj
Nina
N
Bonhoeffer
Sebastian
S
Ramratnam
Bharat
B
Zhang
Linqi
L
Markowitz
Martin M
MM
Nixon
Douglas F
DF
D000208:Acute Disease; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D019562:Viral Load
D019380:Anti-HIV Agents