title: Osteonecrosis in a patient with Crohn's disease unrelated to corticosteroid use.
abstract: Osteonecrosis is a feared complication of corticosteroid use. However, a direct association between corticosteroid use and osteonecrosis has never been proven. The present report examines the case of a patient with longstanding Crohn's disease who had never been treated with corticosteroids and who developed osteonecrosis of the talus. The association of systemic inflammatory disorders with osteonecrosis and the possible association with vascular thrombosis are discussed.
authors.affiliation: Department of Surgery, University of Manitoba, Winnipeg, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Khan
authors.forename: G
authors.initials: G
authors.lastname: Illiffe
authors.forename: D S
authors.initials: DS
authors.lastname: Houston
authors.forename: C N
authors.initials: CN
authors.lastname: Bernstein
mesh_terms: D000208:Acute Disease; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010020:Osteonecrosis / Q000175:diagnosis / Q000209:etiology*; D012008:Recurrence; D013256:Steroids; D013628:Talus / Q000473:pathology*
chemical_list: D000893:Anti-Inflammatory Agents; D013256:Steroids