title: Hypogonadotrophism fails to prevent severe testicular damage induced by total body irradiation in a patient with beta-thalassaemia major and acute lymphoblastic leukaemia.
abstract: Radiation and chemotherapeutic drugs for cancer produce prolonged and often irreversible gonadal damage. To determine whether total body irradiation (TBI)-induced gonadal damage can be prevented by suppression of pituitary gonadotrophin levels, we studied a patient with transfusion dependent homozygous beta-thalassaemia and acute lymphoblastic leukaemia (ALL) who underwent one-antigen mismatched related bone marrow transplantation (BMT). Our data showed that despite having hypogonadotrophic hypogonadism (HH) prior to BMT, the patient developed primary testicular failure following the procedure, indicating that hypogonadotrophism failed to offer protection against TBI-induced testicular damage in this patient. Although this is an interesting case report, no firm conclusions can be drawn from a single patient.
authors.affiliation: Department of Obstetrics and Gynaecology, University College London Hospitals, UK.
authors.forename: R
authors.initials: R
authors.lastname: Chatterjee
authors.forename: P D
authors.initials: PD
authors.lastname: Kottaridis
authors.forename: H H
authors.initials: HH
authors.lastname: McGarrigle
authors.forename: A
authors.initials: A
authors.lastname: Papatryphonos
authors.forename: A H
authors.initials: AH
authors.lastname: Goldstone
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D006065:Gonadotropins, Pituitary / Q000097:blood / Q000172:deficiency; D006801:Humans; D007006:Hypogonadism; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000532:radiotherapy* / Q000628:therapy; D013733:Testicular Diseases / Q000209:etiology*; D013737:Testis / Q000473:pathology / Q000528:radiation effects; D014916:Whole-Body Irradiation / Q000009:adverse effects; D017086:beta-Thalassemia / Q000150:complications / Q000532:radiotherapy* / Q000628:therapy
chemical_list: D006065:Gonadotropins, Pituitary