Treatment of dyslipidemia in diabetes.
Atherosclerosis kills more patients with diabetes than all other causes combined. Treatment must be focused on several targets: glycemic control, bulk reductions of LDL cholesterol, and shifting LDL particle size. Aggressive treatment and reversal of dyslipidemias is a proven prevention for coronary events in patients with type 2 diabetes. Glycemic control with diet, oral hypoglycemic agents, and insulin, when necessary, is often only partially effective in normalizing lipid values in type 2 diabetes. Intensive treatment with lipid-regulating agents, particularly statins, is often necessary to normalize diabetes-associated dyslipidemias. Statins are also the only agents thus far shown in prospective, controlled trials to reduce the risk of coronary events in diabetic patients definitively.
Garber
A J
AJ
Departments of Medicine, Biochemistry and Cell Biology, Department of Family and Community, Baylor College of Medicine, Department of Endocrinology, Diabetes, and Metabolism, Methodist Hospital, Houston, Texas, USA.
Karlsson
F O
FO
D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000150:complications / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control
D000924:Anticholesteremic Agents