title: Beacon-like immunoreactivity in the hypothalamus of Sprague-Dawley rats.
abstract: Distribution of the novel peptide beacon in the hypothalamus of Sprague-Dawley rats was examined by immunohistochemical methods. Beacon-immunoreactive (irBC) neurons were found in the paraventricular, supraoptic, and accessory neurosecretory nuclei, and intensely labeled fibers in the median eminence and infundibulo-pituitary stalk. Scattered cells and/or fibers were noted in the suprachiasmatic nucleus, arcuate nucleus, retrochiasmatic area, lateral and medial preoptic area, as well as anterior and lateral hypothalamic area. The wide distribution of irBC in the hypothalamus of Sprague-Dawley rats suggests that the peptide may influence, in addition to a proposed role in feeding, a multitude of biological activities associated with the hypothalamic-pituitary axis.
authors.affiliation: Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, PO Box 70577 Johnson City, TN 37614, USA.
authors.forename: G Cristina
authors.initials: GC
authors.lastname: Brailoiu
authors.forename: Siok L
authors.initials: SL
authors.lastname: Dun
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Jaw Kang
authors.initials: JK
authors.lastname: Chang
authors.forename: Sonya
authors.initials: S
authors.lastname: Castellino
authors.forename: Nae J
authors.initials: NJ
authors.lastname: Dun
mesh_terms: D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D001069:Appetite Regulation / Q000502:physiology*; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000166:cytology / Q000378:metabolism; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009489:Neurosecretion / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013495:Supraoptic Nucleus / Q000166:cytology / Q000378:metabolism; D014452:Ubiquitins
chemical_list: D009419:Nerve Tissue Proteins; D011506:Proteins; D014452:Ubiquitins; C498170:Ubl5 protein, rat