Strychnine alters response properties of trigeminal nociceptive neurons in the rat.
The purpose of this study was to examine the role of glycine in sensory processes in the spinal trigeminal nucleus oralis (Sp5O). We evaluated the effect of intravenous administration of strychnine, a glycine receptor antagonist, on the responses of Sp5O convergent neurons evoked by innocuous peripheral electrical and mechanical stimuli in halothane-anesthetized rats. Strychnine significantly increased the Abeta-fiber-evoked activities of Sp5O neurons to electrical stimulation in a dose-dependent (0.2-0.8 mg/kg) fashion. The response to air-jet stimulation was also significantly enhanced at the highest dose of strychnine. These findings indicate that glycinergic neurons participate in the control of the flow of information conveyed to Sp5O nociceptive neurons by myelinated low-threshold mechanoreceptive afferents. Thus, alteration of trigeminal glycinergic modulation may contribute to the dynamic mechanical allodynia that occurs in trigeminal neuropathies.
Ressot
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Laboratoire de Physiologie Oro-Faciale, Faculté de Chirurgie Dentaire, 63000 Clermont-Ferrand, France.
Collado
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Molat
J L
JL
Dallel
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R
D000818:Animals; D004558:Electric Stimulation; D018684:Glycine Agents / Q000494:pharmacology*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects*; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013331:Strychnine / Q000494:pharmacology*; D014276:Trigeminal Nerve / Q000166:cytology / Q000187:drug effects*
D018684:Glycine Agents; D013331:Strychnine