title: Activation of programmed cell death (apoptosis) by adriamycin in human neoplastic cells.
abstract: We have studied the occurrence of the apoptosis phenomenon in the action of adriamycin (ADR) on human melanoma cells sensitive (ME18) and resistant (ME18/R) to ADR. The study has shown that the intensity of apoptotic morphological changes noted in melanoma cells depended on the duration of the ADR treatment. We have not observed any positive correlation between the induction of apoptosis and sensitivity to ADR. We have used a fluorescence microscope and flow cytometer to evaluate apoptotic events in cells treated with ADR.
authors.affiliation: Department of Vitamin Drugs, Drug Institute, 30/34 Chelmska Str., 00-725, Warsaw, Poland.
authors.forename: B M
authors.initials: BM
authors.lastname: Gruber
authors.forename: E L
authors.initials: EL
authors.lastname: Anuszewska
authors.forename: J S
authors.initials: JS
authors.lastname: Skierski
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D004317:Doxorubicin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005434:Flow Cytometry; D005456:Fluorescent Dyes; D006801:Humans; D007211:Indoles; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology*; D008856:Microscopy, Fluorescence; D012235:Rhodamines; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D007211:Indoles; D012235:Rhodamines; C007293:DAPI; D004317:Doxorubicin