Stereocontrolled Mannich reaction with enolizable imines using (S,S)-(+)-pseudoephedrine as chiral auxiliary. Asymmetric synthesis of alpha,beta-disubstituted beta-aminoesters and beta-lactams.
Vicario
J L
JL
Departamento de Química Orgánica II, Facultad de Ciencias, Universidad del País Vasco/Euskal Herriko Unibertsitatea, P.O. Box 644, E-48080 Bilbao, Spain. qopbaurm@lg.ehu.es
Badía
D
D
Carrillo
L
L
D000588:Amines / Q000138:chemical synthesis; D004809:Ephedrine / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis; D006868:Hydrolysis; D007097:Imines / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism; D047090:beta-Lactams / Q000138:chemical synthesis*
D000588:Amines; D004952:Esters; D007097:Imines; D007202:Indicators and Reagents; D047090:beta-Lactams; D004809:Ephedrine