Remote neurologic manifestations of cancer.
Paraneoplastic disorders may affect any part of the central or peripheral nervous systems. Although relatively uncommon, these disorders are a significant cause of neurologic morbidity for cancer patients. At least some paraneoplastic syndromes are believed to be caused by an autoimmune reaction against shared tumor-neural antigens. This article summarizes the clinical features of paraneoplastic disorders, the current evidence for autoimmunity, and guidelines for diagnosis and treatment.
Dropcho
Edward J
EJ
Department of Neurology, Indiana University Medical Center, The Richard Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA. edropcho@iupui.edu
D001323:Autoantibodies / Q000276:immunology; D001921:Brain / Q000503:physiopathology*; D002531:Cerebellum / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology; D004679:Encephalomyelitis / Q000503:physiopathology*; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000276:immunology; D008032:Limbic System / Q000503:physiopathology; D016472:Motor Neuron Disease / Q000503:physiopathology; D009369:Neoplasms / Q000276:immunology / Q000503:physiopathology*; D009410:Nerve Degeneration / Q000473:pathology
D001323:Autoantibodies; D006023:Glycoproteins