Severe obstructive sleep apnoea syndrome in an adult patient with Laron syndrome.
A 68 year old patient with Laron syndrome (primary growth hormone (GH) resistance-insensitivity due to a molecular defect of the GH receptor) and severe obstructive sleep apnoea syndrome is described. Treatment with continuous positive air pressure therapy resulted in improved nocturnal sleep, daytime alertness and cognitive functions.
Dagan
Y
Y
Institute for Fatigue and Sleep Medicine, Sheba Medical Centre, Tel-Hashomer 52621, Israel. ydagan@post.tau.ac.il
Abadi
J
J
Lifschitz
A
A
Laron
Z
Z
D000015:Abnormalities, Multiple; D000368:Aged; D005145:Face / Q000002:abnormalities; D005221:Fatigue; D006130:Growth Disorders; D019382:Human Growth Hormone / Q000172:deficiency / Q000378:metabolism*; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications; D011175:Positive-Pressure Respiration; D011986:Receptors, Somatotropin / Q000378:metabolism; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000628:therapy; D013577:Syndrome; D014851:Wakefulness
D011986:Receptors, Somatotropin; D019382:Human Growth Hormone