title: The isolation of a mutation causing abnormal cytokinesis in male and split chromocenter in female meiosis in Drosophila melanogaster.
abstract: The genetic screen for the meiotic mutations showing chromosome non-disjunction in mosaic clones of female germ line generated by FLP-FRT mediated mitotic recombination was performed. The sterile meiotic mutation ff16 (69D1-70A2) was found among the mutants obtained. In the male germ line the mutation showed lack of meiosis 1 cytokinesis and other meiotic abnormalities. The sterility of the mutant is due to the lack of the sperm motility. In female germ line the morphological defects-decreased number of ovarioles and nurse cells in the egg chambers is visible. At the cell level the mutation showed karyosome fragmentation constituting to the gene participation in chromocenter formation/maintance. The cases of the spindle fragmentation revealed the processes acting in female meiotic metaphase. Premeiotic and mitotic defects of the mutation have also been detected.
authors.affiliation: Institute Cytology and Genetics, Novosibirsk, Russia.
authors.forename: S
authors.initials: S
authors.lastname: Fedorova
authors.forename: S
authors.initials: S
authors.lastname: Nokkala
authors.forename: V
authors.initials: V
authors.lastname: Chubykin
authors.forename: L
authors.initials: L
authors.lastname: Omelyanchuk
mesh_terms: D000818:Animals; D002455:Cell Division / Q000235:genetics* / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D006720:Homozygote; D006358:Hot Temperature; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D008540:Meiosis / Q000235:genetics*; D009154:Mutation; D011995:Recombination, Genetic; D013081:Sperm Motility / Q000502:physiology; D013997:Time Factors