title: Expression of receptor protein-tyrosine phosphatase alpha, sigma and LAR during development of the zebrafish embryo.
abstract: Receptor protein-tyrosine phosphatases (RPTPs) are key players in Drosophila development. To study the role of RPTPs in vertebrate development, we have cloned zebrafish (zf) RPTPs, including RPTP alpha (RPTPalpha), RPTP sigma (RPTPsigma) and LAR. These three RPTPs are broadly transcribed in early development. At 24h post fertilisation (hpf), all three genes are expressed in the nervous system in partially overlapping patterns. At 3 days post fertilisation zf-RPTPalpha and zf-LAR show similar expression patterns in the central nervous system (CNS), the pharyngeal arches, the pectoral fins and the spinal cord. Interestingly, zf-LAR is uniquely expressed in the neuromast cells, whereas zf-RPTPsigma expression is confined to the central nervous system.
authors.affiliation: Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van der Sar
authors.forename: M
authors.initials: M
authors.lastname: Betist
authors.forename: J
authors.initials: J
authors.lastname: de Fockert
authors.forename: J
authors.initials: J
authors.lastname: Overvoorde
authors.forename: D
authors.initials: D
authors.lastname: Zivković
authors.forename: J
authors.initials: J
authors.lastname: den Hertog
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D002490:Central Nervous System / Q000196:embryology; D003001:Cloning, Molecular; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis* / Q000235:genetics; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics; D013116:Spinal Cord / Q000196:embryology; D013997:Time Factors; D015027:Zebrafish; D029961:Zebrafish Proteins
chemical_list: D009419:Nerve Tissue Proteins; D016376:Oligonucleotides, Antisense; D011956:Receptors, Cell Surface; D029961:Zebrafish Proteins; D017027:Protein Tyrosine Phosphatases; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4; C516847:ptpra protein, zebrafish