Activation of mu-opioid pathway is associated with the canceling effect of footshock stimulus on the restraint stress-induced inhibition of small intestinal motility in rats.
We previously reported that small intestinal motility was significantly inhibited by restraint stress, but not by footshock stress. In the present study, we found that plasma beta-endorphin levels were more significantly elevated by footshock stress than restraint stress, and that preloading of footshock stimulus canceled the inhibition of small intestinal motility by restraint stress. Pretreatment with the mu-opioid receptor antagonist naltrexone significantly attenuated this canceling effect of footshock stimulus. These results suggest that footshock stimulus may cancel the inhibition of small intestinal motility by restraint stress via activation of mu-opioid receptors.
Tsukada
F
F
Department of Radiopharmacv, Tohoku Pharmaceutical University, Sendai, Japan.
Ohuchi
Y
Y
Terunuma
T
T
Sugawara
M
M
Kohno
H
H
Ohkubo
Y
Y
D000818:Animals; D004558:Electric Stimulation; D005769:Gastrointestinal Motility / Q000502:physiology*; D007274:Injections, Intraperitoneal; D007421:Intestine, Small / Q000503:physiopathology*; D008297:Male; D009271:Naltrexone / Q000008:administration & dosage; D009292:Narcotic Antagonists / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000097:blood* / Q000503:physiopathology; D001615:beta-Endorphin / Q000097:blood
D009292:Narcotic Antagonists; D017450:Receptors, Opioid, mu; D009271:Naltrexone; D001615:beta-Endorphin