Prevention of heterotopic ossification after total hip replacement: a prospective comparison of indomethacin and salmon calcitonin in 60 patients.
We did a prospective consecutive study of prophylaxis for heterotopic ossification (HO) comparing indomethacin (100 mg/day) and salmon calcitonin (3 MRC-U/kg/day) for 14 days. Each group consisted of 30 patients. 19 patients in the indomethacin group and 2 in the calcitonin group developed HO. We conclude that use of calcitonin in the prophylaxis of HO after total hip replacement is more effective than indomethacin.
Günal
I
I
Department of Orthopedics, Dokuz Eylül University Hospital, Izmir, Turkey. izge.gunal@deu.edu.tr
Hazer
B
B
Seber
S
S
Göktürk
E
E
Turgut
A
A
Köse
N
N
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects*; D002116:Calcitonin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000517:prevention & control*; D011446:Prospective Studies
D000894:Anti-Inflammatory Agents, Non-Steroidal; C028815:salmon calcitonin; D002116:Calcitonin; D007213:Indomethacin