Deletion 5p11 accompanied by multiple numerical changes in testicular lymphoma.
We describe a case of testicular B cell lymphoma with deletion of chromosome 5, del(5)(p11), as a sole structural abnormality. Histopathological diagnosis of the tumor was a high-grade lymphoma of the diffuse type containing cells positive for B cell specific antigen (CD20) and negative for the leukocyte common antigen (CD45). Deletion 5p may define the region of a tumor suppressor gene that could be associated with tumor progression and invasiveness and may serve as an indicator of poor prognosis in testicular lymphomas.
Espinoza
L A
LA
Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirãa Preto, São Paulo, Brazil. lae2@georgetown.edu
Neto
J B
JB
Popescu
N C
NC
Casartelli
C
C
D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D018450:Disease Progression; D016147:Genes, Tumor Suppressor; D006801:Humans; D007621:Karyotyping; D017493:Leukocyte Common Antigens / Q000032:analysis; D008223:Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D013736:Testicular Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*
D018951:Antigens, CD20; D017493:Leukocyte Common Antigens