Chronobiological aspects of melatonin-produced antioxidant effects in senescent rats.
Melatonin in low doses of (0.05 and 0.5 mg/kg) administered to senescent rats in winter and summer inhibited free radical oxidation and LPO. The antioxidant effect of melatonin increased with increasing the dose of the hormone. Changes in test parameters were more pronounced in winter, but the directionality of changes did not depend on the duration of the light period.
Somova
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V. Ya. Danilevskii Institute of Problems of Endocrine Pathology, Ukrainian Academy of Sciences, Kharkov. 10. fez@email.itl.net.ua
Kolodub
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FA
Bondarenko
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D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D016922:Cellular Senescence; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide / Q000378:metabolism; D008027:Light; D015227:Lipid Peroxidation; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000975:Antioxidants; D006861:Hydrogen Peroxide; D008550:Melatonin