Effect of mesna on lethal effect and hematological toxicity of taxol and vepeside in mice.
Mesna, an SH-containing uroprotector, attenuates the lethal effect and hematological toxicity of vepeside and taxol, but did not reduce specific activities of the studied cytostatics in mice with transplanted tumors. This selective antitoxic effect of mesna towards vepeside and taxol allows to intensify the anticancer chemotherapy with these highly effective but extremely toxic cytostatics and to improve the efficiency of anticancer therapy.
Bogush
T A
TA
Laboratory of Medical Chemistry, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow. bogush@med.chem.msu.ru
Koldaeva
E Y
EY
Smirnova
G B
GB
Bogush
E A
EA
Konyaeva
O I
OI
Khrustalev
S A
SA
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000633:toxicity*; D008297:Male; D015080:Mesna / Q000627:therapeutic use*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D017239:Paclitaxel / Q000633:toxicity*; D020011:Protective Agents / Q000627:therapeutic use*; D013997:Time Factors
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D020011:Protective Agents; D005047:Etoposide; D015080:Mesna; D017239:Paclitaxel