title: Small changes in expression affect predisposition to tumorigenesis.
abstract: We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.
authors.affiliation: The Howard Hughes Medical Institute, The Oncology Center, and The Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.
authors.forename: Hai
authors.initials: H
authors.lastname: Yan
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Dobbie
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Gruber
authors.forename: Sanford
authors.initials: S
authors.lastname: Markowitz
authors.forename: Kathy
authors.initials: K
authors.lastname: Romans
authors.forename: Francis M
authors.initials: FM
authors.lastname: Giardiello
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Kinzler
authors.forename: Bert
authors.initials: B
authors.lastname: Vogelstein
mesh_terms: D000236:Adenoma / Q000235:genetics*; D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000483:Alleles; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005786:Gene Expression Regulation; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D006801:Humans; D019656:Loss of Heterozygosity; D016133:Polymerase Chain Reaction; D013698:Templates, Genetic
chemical_list: D018076:DNA, Complementary; D004273:DNA, Neoplasm