Role of dopamine receptors in the kidney in the regulation of blood pressure.
Regulation by dopamine of cardiovascular function, renal function and systemic blood pressure regulation is multifaceted. Each of the five dopamine receptor subtypes participates in the regulation of blood pressure by mechanisms specific for the subtype. Some receptors regulate blood pressure by influencing the central or peripheral nervous system; others influence epithelial transport and regulate the secretion and receptors of several humoral agents. The D1, D3, and D4 receptors interact with the renin-angiotensin system, while the D2 and D5 receptors interact with the sympathetic nervous system to regulate blood pressure.
Jose
Pedro A
PA
Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007, USA. pjose01@georgetown.edu
Eisner
Gilbert M
GM
Felder
Robin A
RA
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D011954:Receptors, Dopamine / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
D011954:Receptors, Dopamine; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases; D019204:GTP-Binding Proteins