title: Homology between a 173-kb region from mouse chromosome 10, telomeric to the Ifng locus, and human chromosome 12q15.
abstract: We sequenced a 173-kb region of mouse chromosome 10, telomeric to the Ifng locus, and compared it with the human homologous sequence located on chromosome 12q15 using various sequence analysis programs. This region has a low density of genes: one gene was detected in the mouse and the human sequences and a second gene was detected only in the human sequence. The mouse gene and its human orthologue, which are expressed in the immune system at a low level, produce a noncoding mRNA. Nonexpressed sequences show a higher degree of conservation than exons in this genomic region. At least three of these conserved sequences are also conserved in a third mammalian species (sheep or cow).
authors.affiliation: Unité des Virus Lents (CNRS URA 1930), Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
authors.forename: S
authors.initials: S
authors.lastname: Vigneau
authors.forename: F
authors.initials: F
authors.lastname: Levillayer
authors.forename: H
authors.initials: H
authors.lastname: Crespeau
authors.forename: L
authors.initials: L
authors.lastname: Cattolico
authors.forename: B
authors.initials: B
authors.lastname: Caudron
authors.forename: F
authors.initials: F
authors.lastname: Bihl
authors.forename: C
authors.initials: C
authors.lastname: Robert
authors.forename: M
authors.initials: M
authors.lastname: Brahic
authors.forename: J
authors.initials: J
authors.lastname: Weissenbach
authors.forename: J F
authors.initials: JF
authors.lastname: Bureau
mesh_terms: D000818:Animals; D001483:Base Sequence; D022202:Chromosomes, Artificial, Bacterial; D002881:Chromosomes, Human, Pair 12; D018076:DNA, Complementary; D015870:Gene Expression; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D016615:Telomere
chemical_list: D018076:DNA, Complementary; D007371:Interferon-gamma