title: Synthesis and cytotoxic activities of analogues of thuriferic acid.
abstract: Several analogues of thuriferic acid and derivatives, with the 3,4-methylenedioxyphenyl ring replaced by naphthalene, furan, thiophene and carbazole ring systems, have been prepared. The synthetic strategy is based on a conjugate addition-alkylation methodology followed by cationic cyclization in order to obtain the isopodophyllone analogues, which are transformed in the thuriferic acids. Their cytotoxic activities against several tumour cells lines are also described.
authors.affiliation: Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia. Campus Miguel de Unamuno, 37007-Salamanca, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Madrigal
authors.forename: Pilar
authors.initials: P
authors.lastname: Puebla
authors.forename: Angel
authors.initials: A
authors.lastname: Ramos
authors.forename: Rafael
authors.initials: R
authors.lastname: Peláez
authors.forename: Dolores
authors.initials: D
authors.lastname: Grávalos
authors.forename: Esther
authors.initials: E
authors.lastname: Caballero
authors.forename: Manuel
authors.initials: M
authors.lastname: Medarde
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods*; D002227:Carbazoles / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D009281:Naphthalenes; C452999:thuriferic acid