Enhancement of intestinal growth and repair by growth factors.
Recently, glucagon-like peptide 2 has emerged as a potent stimulator of epithelial growth, joining insulin-like growth factor I, hepatocyte growth factor and keratinocyte growth factor as potential treatment modalities for intestinal disorders associated with loss of mucosal mass, such as short bowel syndrome. Investigations into other members of the expanded epidermal growth factor peptide family, the development of more potent peptide analogues, and advances in the development of enterally administered bioactive growth factor formulations further expands the repertoire of epithelial growth factors applicable to conditions associated with epithelial insufficiency.
Howarth
G S
GS
Child Health Research Institute, North Adelaide, South Australia. gordon.howarth@adelaide.edu.au
Shoubridge
C A
CA
D000222:Adaptation, Physiological; D004815:Epidermal Growth Factor / Q000502:physiology; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors / Q000502:physiology / Q000627:therapeutic use; D053767:Glucagon-Like Peptide 2; D004763:Glucagon-Like Peptides; D006133:Growth Substances / Q000502:physiology* / Q000627:therapeutic use; D017228:Hepatocyte Growth Factor / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology*; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides / Q000502:physiology / Q000627:therapeutic use; D012038:Regeneration; D012778:Short Bowel Syndrome / Q000188:drug therapy / Q000473:pathology; D013002:Somatomedins / Q000502:physiology / Q000627:therapeutic use; D016211:Transforming Growth Factor alpha / Q000502:physiology; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3
C496453:FGF7 protein, human; D053767:Glucagon-Like Peptide 2; D006133:Growth Substances; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides; D013002:Somatomedins; C099037:TFF3 protein, rat; D016211:Transforming Growth Factor alpha; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D004763:Glucagon-Like Peptides; D017228:Hepatocyte Growth Factor