title: Premature rupture of the membranes: an evidence-based approach to clinical care.
abstract: Management of the patient with premature rupture of membranes is a relatively common but often perplexing problem frequently faced by the obstetrician. Despite the recent advances in perinatal care, premature membrane rupture, especially in the preterm patient, remains a potentially serious complication with important maternal and fetal implications. This review will address the important questions concerning the management of premature rupture of membranes and will attempt to provide comprehensive answers as they appear in the medical literature.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Cedars-Sinai Medical Center, Burns and Allen Research Institute, Los Angeles, California, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Naylor
authors.forename: K
authors.initials: K
authors.lastname: Gregory
authors.forename: C
authors.initials: C
authors.lastname: Hobel
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000553:Ambulatory Care; D019072:Antibiotic Prophylaxis; D015415:Biomarkers; D023802:Cerclage, Cervical / Q000009:adverse effects; D002821:Chorioamnionitis / Q000175:diagnosis / Q000517:prevention & control; D036861:Delivery, Obstetric / Q000379:methods; D019317:Evidence-Based Medicine; D005260:Female; D005316:Fetal Distress / Q000628:therapy; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000628:therapy*; D005323:Fetal Monitoring / Q000379:methods; D005325:Fetal Organ Maturity; D005865:Gestational Age; D006760:Hospitalization; D006801:Humans; D007231:Infant, Newborn; D007745:Labor Onset; D008168:Lung / Q000196:embryology; D007752:Obstetric Labor, Premature / Q000628:therapy; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy; D015145:Tocolysis
chemical_list: D000305:Adrenal Cortex Hormones; D015415:Biomarkers