From progesterone to active Cdc2 in Xenopus oocytes: a puzzling signalling pathway.
Since almost two decades, it is known that progesterone is responsible of the release of the prophase I arrest of amphibian oocytes and leads to the activation of the universal MPF, through a puzzling transduction pathway. It involves negative regulation of the cAMP-dependent protein kinase (PKA) and synthesis of new proteins, among them the c-Mos protooncogene product. The implication of the Mos/mitogenic activated protein kinase (MAP kinase) pathway in Cdc2 activation has been extensively studied and is now at the centre of a controversial debate. In this paper, we discuss the current progress and our recent results on the molecular mechanisms allowing progesterone to activate MPF and propose a model to partly resolve the long-standing inconsistencies concerning the role of Mos/MAP kinase during this process.
Karaiskou
A
A
Laboratoire de Biologie du Développement, UMR-CNRS 7622, Université Pierre et Marie Curie, Paris, France.
Dupré
A
A
Haccard
O
O
Jessus
C
C
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D004789:Enzyme Activation; D016258:Genes, mos / Q000502:physiology; D006801:Humans; D016200:Maturation-Promoting Factor / Q000502:physiology; D008540:Meiosis / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D020559:Monomeric GTP-Binding Proteins / Q000502:physiology; D009865:Oocytes / Q000502:physiology*; D011374:Progesterone / Q000378:metabolism*; D015398:Signal Transduction; D014981:Xenopus; D029867:Xenopus Proteins
D018797:Cell Cycle Proteins; D016213:Cyclins; C486530:SPDYA protein, human; D029867:Xenopus Proteins; C119055:ls27 protein, Xenopus; D011374:Progesterone; D016203:CDC2 Protein Kinase; D016200:Maturation-Promoting Factor; D020928:Mitogen-Activated Protein Kinases; D020559:Monomeric GTP-Binding Proteins