title: Fully convergent solid phase synthesis of antifreeze glycoprotein analogues.
abstract: The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26-44% yield demonstrating the utility of this approach.
authors.affiliation: Department of Chemistry, State University of New York at Binghamton, Binghamton, New York 13902, USA.
authors.forename: A
authors.initials: A
authors.lastname: Eniade
authors.forename: R N
authors.initials: RN
authors.lastname: Ben
mesh_terms: D021301:Antifreeze Proteins / Q000138:chemical synthesis*; D004187:Disaccharides / Q000737:chemistry; D006031:Glycosylation; D008970:Molecular Weight; D012117:Resins, Synthetic / Q000737:chemistry
chemical_list: D021301:Antifreeze Proteins; D004187:Disaccharides; D012117:Resins, Synthetic