Effects of pirfenidone on vascular smooth muscle cell proliferation and intimal hyperplasia following arterial balloon injury.
Waller
J R
JR
Division of Transplant Surgery, Liecester General Hospital, Leicester, UK. julian@waller79.fsnet.co.uk
Murphy
G J
GJ
Metcalfe
M S
MS
Bicknell
G R
GR
Saunders
R N
RN
Margolin
S B
SB
Nicholson
M L
ML
D000800:Angioplasty, Balloon / Q000009:adverse effects*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D024061:Collagen Type III / Q000235:genetics; D016001:Confidence Intervals; D005786:Gene Expression Regulation / Q000187:drug effects; D006965:Hyperplasia; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000473:pathology*; D011728:Pyridones / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000235:genetics; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology*; D017540:Tunica Media / Q000187:drug effects / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D024061:Collagen Type III; D011728:Pyridones; D019715:Tissue Inhibitor of Metalloproteinase-1; D016212:Transforming Growth Factor beta; C093844:pirfenidone; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9