CD4 and CD8 cytokine-producing T cells are transiently reduced following cyclosporine intake: maximal inhibition occurs at 2 hours coincidental with drug C(max).
Mora
J R
JR
Laboratorio de Immunología Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
Bono
M R
MR
Rosemblatt
M
M
Rodriguez
S
S
Morales
J
J
Buckel
E
E
Fierro
A
A
D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D016572:Cyclosporine / Q000494:pharmacology*; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007700:Kinetics; D013997:Time Factors; D014181:Transplantation Immunology
D016207:Cytokines; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D007371:Interferon-gamma; D016572:Cyclosporine