Neuronal signal transduction pathways: wasteland or the promised land?
Proteins used in signal transduction pathways are commonly found in different cell types and organs. However, specific proteins whose expression is highly restricted are also utilized for allowing discrete responsiveness to signals that are otherwise ignored by other cells. How the brain uses common and specific signal proteins for communication within and beyond the cerebrum has been an area of intense study. A new book concentrates on the signaling that occurs in the brain under normal and pathological conditions--memory, apoptosis, neurodegeneration, depression, and drug dependence--and is filled with chapters written by experts in neurobiology and neurophysiology. Bryan Roth reviews the book and discusses in detail several chapters that may lead to promising future research.
Roth
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Departments of Psychiatry, Biochemistry, and Neuroscience, Case Western Reserve University, Cleveland, OH 44106, USA.
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D002450:Cell Communication / Q000502:physiology*; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology; D015536:Down-Regulation; D006801:Humans; D009474:Neurons / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D015398:Signal Transduction / Q000502:physiology*
D018759:Adrenergic Uptake Inhibitors; D000928:Antidepressive Agents; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D017367:Selective Serotonin Reuptake Inhibitors