title: 5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium.
abstract: 5-Demethylovalicin was isolated from the fermentation broth Chrysosporium lucknowense and the structure was identified by spectroscopic methods. 5-Demethylovalicin inhibited the recombinant human MetAP-2 (IC(50)=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC(50)=100 nM) in cell proliferation assay without cytotoxicity on the transformed and cancer cell lines.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, 52-Eundong, Yusong, 305-333, Taejon, Republic of Korea. sonkh@mail.kribb.re.kr
authors.forename: Kwang-Hee
authors.initials: KH
authors.lastname: Son
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Kwon
authors.forename: Ha-Won
authors.initials: HW
authors.lastname: Jeong
authors.forename: Hyae-Kyeong
authors.initials: HK
authors.lastname: Kim
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Kim
authors.forename: Yie-Hwa
authors.initials: YH
authors.lastname: Chang
authors.forename: Jung-Do
authors.initials: JD
authors.lastname: Choi
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
mesh_terms: D000626:Aminopeptidases / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D002912:Chrysosporium / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: C448859:5-demethylovalicin; D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; D012717:Sesquiterpenes; D000626:Aminopeptidases; C106541:methionine aminopeptidase 2; D008666:Metalloendopeptidases