19F-MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation.
A method for in vivo measurement of oxygen partial pressure (pO2) in porcine lungs during partial liquid ventilation (PLV) with perflubron (PFOB) was developed. A pulse sequence for high-resolution MRI of the distribution of PFOB in the lung after intratracheal administration was developed as well. Moreover, quantitative measurements of longitudinal relaxation time T(1) of (19)F resonances for assessment of regional pO2 are described. Due to the need to acquire data during a single expiratory breathhold, only low SNRs were achieved in vivo. Therefore, simulations were performed to investigate the influence of background noise on T(1) values calculated from data with low SNR. Based on these simulations, a postprocessing strategy was developed to correct for systematic errors by background noise prior to quantitative analysis. Results of a pilot study in pigs under conditions of PLV are presented.
Laukemper-Ostendorf
Simone
S
Department of Radiology, Johannes Gutenberg-University, Mainz, Germany.
Scholz
Alexander
A
Bürger
Katja
K
Heussel
Claus P
CP
Schmittner
Marc
M
Weiler
Norbert
N
Markstaller
Klaus
K
Eberle
Balthasar
B
Kauczor
Hans-Ulrich
HU
Quintel
Michael
M
Thelen
Manfred
M
Schreiber
Wolfgang G
WG
D000818:Animals; D003287:Contrast Media; D004655:Emulsions; D005461:Fluorine; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D021061:Liquid Ventilation; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D010100:Oxygen; D010313:Partial Pressure; D013552:Swine
D003287:Contrast Media; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D005461:Fluorine; C003072:perflubron; D010100:Oxygen