Clinical application of living-related conjunctival-limbal allograft.
OBJECTIVE
To report one successful case of conjunctival-limbal allograft for the treatment of a severe ocular surface disorder.


METHODS
Interventional case report. A 9-year-old patient suffering from Stevens-Johnson syndrome with total keratinization of the ocular surface of both eyes was treated in the left eye by corneal and conjunctival stem cell transplantation. Oral cyclosporin A and topical autologous serum and corticosteroids were administered.


RESULTS
Mucosal epithelial phenotype was maintained in the left eye at most recent examination for more than 3 years after ocular surface reconstruction.


CONCLUSIONS
A total keratinized ocular surface may be treated with the combination of conjunctival and corneal stem cell transplantation.
Tsubota
Kazuo
K
Department of Ophthalmology, Tokyo Dental College, Ichikawa-shi, Chiba, Japan. tsubota@tdc.ac.jp
Shimmura
Shigeto
S
Shinozaki
Naoshi
N
Holland
Edward J
EJ
Shimazaki
Jun
J
D002648:Child; D003228:Conjunctiva / Q000166:cytology*; D003231:Conjunctivitis / Q000188:drug therapy / Q000601:surgery; D004847:Epithelial Cells / Q000637:transplantation*; D005938:Glucocorticoids / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000601:surgery; D016850:Limbus Corneae / Q000166:cytology*; D019520:Living Donors; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000601:surgery*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014792:Visual Acuity
D005938:Glucocorticoids