title: Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase.
abstract: Cyclic acid anhydrides possessing a lipid chain have been shown to be a new class of non-peptidic inhibitors of geranylgeranyl protein-transferase type I (GGPTase-I).
authors.affiliation: Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK. c.m.marson@ucl.ac.uk
authors.forename: Charles M
authors.initials: CM
authors.lastname: Marson
authors.forename: Alphonso S
authors.initials: AS
authors.lastname: Rioja
authors.forename: Greg
authors.initials: G
authors.lastname: Brooke
authors.forename: R Charles
authors.initials: RC
authors.lastname: Coombes
authors.forename: David M
authors.initials: DM
authors.lastname: Vigushin
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000812:Anhydrides / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000812:Anhydrides; D004791:Enzyme Inhibitors; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I