Antipneumococcal activity of BMS 284756 compared to those of six other agents.
Antipneumococcal activity of BMS 284756 was compared to those of six agents by MIC and time-kill methodologies. BMS 284756 had the lowest MICs compared to those of ciprofloxacin, levofloxacin, and moxifloxacin against quinolone-susceptible (< or =0.016 to 0.06 microg/ml) and quinolone-resistant (0.03 to 1 microg/ml) pneumococci. BMS 284756 was bactericidal against 11 of 12 strains at two times the MIC after 24 h.
Pankuch
Glenn A
GA
Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
Nagai
Kensuke
K
Davies
Todd A
TA
Jacobs
Michael R
MR
Appelbaum
Peter C
PC
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D024841:Fluoroquinolones; D006801:Humans; D007211:Indoles; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D015363:Quinolones; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013997:Time Factors
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007211:Indoles; D015363:Quinolones; D002939:Ciprofloxacin; C419689:garenoxacin