Multiple calcium stores: separate but interacting.
Multiple mechanisms exist for increasing the concentration of intracellular calcium. This Perspective by Lee is one in a series on intracellular calcium release mechanisms and focuses on the calcium store operated by nicotinic acid adenine dinucleotide phosphate (NAADP). The characterization of the NAADP-operated calcium store as separate from the inositol trisphosphate (IP(3))-operated and cyclic ADP-ribose (cADPR)-operated calcium stores is discussed. Lee also addresses the role of NAADP in regulating intracellular calcium fluctuations during fertilization and hormonal activation of pancreatic acinar cells.
Lee
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Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA. leehc@tc.umn.edu
D000246:Adenosine Diphosphate Ribose / Q000031:analogs & derivatives* / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D036563:Cyclic ADP-Ribose; D006801:Humans; D007295:Inositol Phosphates / Q000502:physiology; D009249:NADP / Q000031:analogs & derivatives* / Q000502:physiology
D007295:Inositol Phosphates; D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D009249:NADP; C024376:NAADP; C049924:inositol-1,2-cyclic-4,5-triphosphate; D002118:Calcium