title: Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium.
abstract: OBJECTIVE
  To investigate the anti-implantation mechanism of mifepriston.
  
  
  METHODS
  In situ hybridization and immunohistochemistry were applied to determine mRNA and protein.
  
  
  RESULTS
  After mifepriston injection, the number of implantation sites were obviously reduced, mifepriston could inhibit the embryo implantation in mouse. The expression of apoptosis related genes, Fas and FasL, in mouse endometrium was also decreased after mifepriston treatment.
  
  
  CONCLUSIONS
  The expression of apoptosis related genes Fas and FasL is regulated by mifepriston and the inhibitory effect of mifepriston on the embryo implantation may be mediated by action on the Fas/FasL system.
authors.affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.forename: F H
authors.initials: FH
authors.lastname: Xu
authors.forename: X C
authors.initials: XC
authors.lastname: Zhou
authors.forename: X B
authors.initials: XB
authors.lastname: Han
authors.forename: Y X
authors.initials: YX
authors.lastname: Liu
mesh_terms: D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D010064:Embryo Implantation / Q000187:drug effects; D004717:Endometrium / Q000166:cytology / Q000378:metabolism*; D053222:Fas Ligand Protein; D005260:Female; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics; D019014:fas Receptor / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000021:Abortifacient Agents, Steroidal; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D019014:fas Receptor; D015735:Mifepristone