Hodgkin's lymphoma of T-cell type: clonal association with a CD30+ cutaneous lymphoma.
The derivation of Reed-Sternberg cells in Hodgkin's lymphoma has been a subject of great interest. In most cases, Reed-Sternberg cells seem to be derived from germinal center B cells. In few sporadic cases, a T-cell origin has been shown. This article supports the concept of a T-cell derivation for rare cases of Hodgkin's lymphoma and provides evidence of a novel mechanism of pathogenesis from chronic inflammation in the skin.
Kadin
M E
ME
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Drews
R
R
Samel
A
A
Gilchrist
A
A
Kocher
O
O
D001483:Base Sequence; D002999:Clone Cells; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006689:Hodgkin Disease / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis* / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000737:chemistry / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D018807:Polymorphism, Single-Stranded Conformational; D016539:Reed-Sternberg Cells / Q000737:chemistry*; D012689:Sequence Homology, Nucleic Acid; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000737:chemistry / Q000150:complications* / Q000235:genetics
D017730:Ki-1 Antigen