title: The in vitro activity of BMS-284756, a new des-fluorinated quinolone.
abstract: The in vitro activity of BMS-284756 (previously T-3811ME), a des-fluoro(6) quinolone, was investigated and compared with those of six other antimicrobial agents. Susceptibility tests were performed on 919 Gram-positive, Gram-negative (including nine quinolone-resistant Escherichia coli) and anaerobic bacteria, three Chlamydia isolates and four Mycobacteria spp. BMS-284756 was marginally less active against the Enterobacteriaceae, but was the most active quinolone against staphylococci, enterococci and peptostreptococci. Against Streptococcus pneumoniae, BMS-284756 and gemifloxacin were more active than other quinolones. The MIC(90) of BMS-284756 was > or = 2 mg/L for the following bacteria: E. coli (MIC(90) 16 mg/L), Acinetobacter spp. (8 mg/L), Pseudomonas aeruginosa (64 mg/L) and Enterococcus faecium (4 mg/L). The MIC of BMS-284756 for Mycobacterium spp. was within one dilution of the MIC of ciprofloxacin. BMS-284756 was markedly more active than ciprofloxacin against the Chlamydia isolates tested.
authors.affiliation: Department of Medical Microbiology, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QH, UK. T.M.A.Weller@bham.ac.uk
authors.forename: T M A
authors.initials: TM
authors.lastname: Weller
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.forename: G
authors.initials: G
authors.lastname: Jevons
authors.forename: R
authors.initials: R
authors.lastname: Wise
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000502:physiology; D024841:Fluoroquinolones; D006801:Humans; D007211:Indoles; D007769:Lactams; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D015363:Quinolones; D015610:Serum Bactericidal Test / Q000706:statistics & numerical data
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007211:Indoles; D007769:Lactams; D015363:Quinolones; C419689:garenoxacin