Biodegradable dextran-polylactide hydrogel networks: their swelling, morphology and the controlled release of indomethacin.
Biodegradable polymer hydrogel networks based on hydrophilic dextran derivative of allyl isocyanate (dex-AI) and hydrophobic poly (D,L) lactide diacrylate macromer (PDLLAM) were synthesized, and their swelling and morphological properties were studied. During a 2-day incubation, the higher the PDLLAM composition in the hydrogel, the slower the swelling as well as the lower the extent of swelling were. A 3D porous network structure was observed by scanning electron microscope. The rate of formation of this 3D porous network structure depended on the hydrophilicity of the components, their composition ratio, and the degradation time. The highly hydrophilic dex-AI component facilitated the formation of this 3D porous network structure at an earlier immersion period, while the degradability of the PDLLAM component would make this 3D porous network structure more open at a later immersion period. Indomethacin, a low molecular weight and moderately hydrophobic drug, was incorporated into the hydrogels for the release study in pH 7.4 phosphate buffer solution at 37 degrees C. The release kinetics suggested, as the PDLLAM composition increased, the indomethacin diffusion coefficient (D) and release half life time (t(1/2)) decreased, while the release index n increased. The controlled release mechanism was determined by the combination of three factors: the rate and degree of formation of swelling-induced 3D porous structure in the hydrogel, the hydrolytic degradation of PDLLAM components, and the hydrophobic interaction between PDLLAM and IDM.
Zhang
Yeli
Y
Fiber and Polymer Science Program, Department of Textiles and Apparel & Biomedical Engineering Program, Cornell University, Ithaca, New York 14853-4401, USA.
Chu
Chih-Chang
CC
D001672:Biocompatible Materials / Q000737:chemistry*; D001673:Biodegradation, Environmental; D003692:Delayed-Action Preparations; D003911:Dextrans / Q000737:chemistry*; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry; D066298:In Vitro Techniques; D007213:Indomethacin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D013997:Time Factors
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D003911:Dextrans; D020100:Hydrogels; D011091:Polyesters; C419144:dextran-polylactide hydrogel; D007213:Indomethacin