The JAK/STAT pathway and Drosophila development.
The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling.
Luo
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The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A&M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA. hluo@medicine.tamu.edu
Dearolf
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D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005121:Extremities / Q000196:embryology; D005123:Eye / Q000196:embryology; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D053612:Janus Kinases; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology*; D050791:STAT Transcription Factors; D019849:Sex Determination Processes; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors; D014921:Wings, Animal / Q000196:embryology
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006023:Glycoproteins; D019476:Insect Proteins; D050791:STAT Transcription Factors; C105675:Stat92E protein, Drosophila; D015534:Trans-Activators; D014157:Transcription Factors; C115570:upd1 protein, Drosophila; D011505:Protein-Tyrosine Kinases; D053612:Janus Kinases; C085845:hop protein, Drosophila