Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues.
We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives.
Jain
Rahul
R
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, 160 062, Punjab, India. rahuljain@mailmetoday.com
Singh
Jatinder
J
Perlman
Jeffery H
JH
Gershengorn
Marvin C
MC
D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D013973:Thyrotropin-Releasing Hormone