title: Dopamine characteristics in rat genotypes with distinct susceptibility to epileptic activity: apomorphine-induced stereotyped gnawing and novelty/amphetamine-induced locomotor stimulation.
abstract: Rat genotypes differ in their susceptibility to spontaneously occurring spike-wave discharges and in their dopaminergic properties. In a previous study, it was found that spike-wave discharge incidence decreased in the following order in four rat genotypes during baseline and following injection with the dopamine antagonist haloperidol: apomorphine-susceptible (APO-SUS) > WAG/Rij > apomorphine-unsusceptible (APO-UNSUS) and ACI rats. The question in the present study was to what extent certain dopaminergic properties are pathognomonic for epileptic rats. Therefore, behavioral responses were assessed in order to investigate the dopaminergic properties in the four rat genotypes. Apomorphine-induced gnawing data imply that the dopamine activity of the nigrostriatal system in the WAG/Rij rats is higher than in APO-SUS but lower than in the ACI and APO-UNSUS rats. Furthermore, in previous studies APO-SUS have been shown to have a higher novelty/amphetamine-induced locomotion, indicative of a higher dopamine reactivity of the mesolimbic system as compared to APO-UNSUS rats. Results from the present study showed that WAG/Rij rats have a higher locomotor responsiveness to novelty/amphetamine, indicating a higher dopamine reactivity of the mesolimbic system in comparison to the ACI rats. It is suggested that the functional dopaminergic mesolimbic dominance is an important factor in the susceptibility to show spontaneously occurring spike-wave discharges.
authors.affiliation: NICI / Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands. natasja.debruin@numico-research.nl
authors.forename: N M
authors.initials: NM
authors.lastname: de Bruin
authors.forename: E L
authors.initials: EL
authors.lastname: van Luijtelaar
authors.forename: A R
authors.initials: AR
authors.lastname: Cools
authors.forename: B A
authors.initials: BA
authors.lastname: Ellenbroek
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects / Q000235:genetics*; D004298:Dopamine / Q000502:physiology*; D004832:Epilepsy, Absence / Q000235:genetics* / Q000503:physiopathology; D005838:Genotype; D006220:Haloperidol / Q000494:pharmacology; D008032:Limbic System / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000503:physiopathology; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D000661:Amphetamine; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine