D-amphetamine does not improve outcome of somatosensory training.
BACKGROUND
D-amphetamine has been shown to affect early stages of stroke recovery, and may have a beneficial effect on functions when administered later after stroke.


OBJECTIVE
To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated.


METHODS
Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design.


RESULTS
All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine.


CONCLUSIONS
No beneficial effect of D-amphetamine on somatosensory training improvements was found in healthy subjects.
Knecht
S
S
Department of Neurology, University of Münster, Germany. knecht@uni-muenster.de
Imai
T
T
Kamping
S
S
Breitenstein
C
C
Henningsen
H
H
Lütkenhöner
B
B
Ringelstein
E B
EB
D000328:Adult; D000704:Analysis of Variance; D003913:Dextroamphetamine / Q000008:administration & dosage*; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D010812:Physical Stimulation; D020521:Stroke / Q000188:drug therapy / Q000503:physiopathology*
D003913:Dextroamphetamine