title: Salmonella-induced macrophage death: the role of caspase-1 in death and inflammation.
abstract: Salmonella typhimurium invades host macrophages and can induce either an almost immediate cell death or establish an intracellular niche within the phagocytic vacuole. Rapid cell death depends on the Salmonella pathogenicity island SPI1 and the host protein caspase-1, a member of the pro-apoptotic caspase family of proteases. Caspase-1-dependent cell death leads to the activation of the potent pro-inflammatory cytokines interleukin (IL)-1beta and IL-18 to produce bioactive cytokines. Animal studies indicate that the activation of these cytokines is necessary for efficient colonization of the mouse gastrointestinal tract. Salmonella that reside in the phagocytic vacuole do not cause this early cell death and can trigger a macrophage death at a much later time point. This late-phase cell death is dependent on SPI2-encoded genes and ompR.
authors.affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. dmonack@leland.stanford.edu
authors.forename: D M
authors.initials: DM
authors.lastname: Monack
authors.forename: W W
authors.initials: WW
authors.lastname: Navarre
authors.forename: S
authors.initials: S
authors.lastname: Falkow
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020170:Caspase 1 / Q000502:physiology*; D002478:Cells, Cultured; D004064:Digestive System / Q000382:microbiology; D006801:Humans; D007249:Inflammation / Q000382:microbiology / Q000503:physiopathology*; D008264:Macrophages / Q000382:microbiology* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D012475:Salmonella / Q000472:pathogenicity*; D012480:Salmonella Infections / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000382:microbiology; D012486:Salmonella typhimurium / Q000472:pathogenicity
chemical_list: D020170:Caspase 1