title: Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa.
abstract: Assay-guided fractionation of the EtOAc soluble fraction of the rhizomes of Curcuma longa furnished three DPPH free radical scavenging diarylheptanoids, curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3). Compounds 1-3 showed the DPPH radical scavenging effects with IC(50) values of 2.8, 39.2, 308.7 microM, respectively. L-Ascorbic acid and resveratrol as positive controls exhibited IC(50) values of 22.5 and 25.0 microM, respectively. Compounds 1-3 showed significant hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of 1-3 are 86.9, 70.7, and 50.2 microM, respectively. Silybin (EC(50) = 69.0 microM) and silychristin (EC(50) = 82.7 microM) were used as positive controls.
authors.forename: E K
authors.initials: EK
authors.lastname: Song
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: N Y
authors.initials: NY
authors.lastname: Kim
authors.forename: N H
authors.initials: NH
authors.lastname: An
authors.forename: J A
authors.initials: JA
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: Y C
authors.initials: YC
authors.lastname: Kim
mesh_terms: D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D030024:Curcuma; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D036381:Diarylheptanoids; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D027343:Rhizome / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D003373:Coumaric Acids; D036381:Diarylheptanoids; D016166:Free Radical Scavengers; C034786:bisdemethoxycurcumin; D003474:Curcumin; C050229:demethoxycurcumin