title: Mechanisms of epileptogenicity in focal malformations caused by abnormal cortical development.
abstract: In this article, the authors review the cellular mechanisms of epileptogenicity in malformations caused by abnormalities of cortical development as related to neuronal excitation, reduced inhibition, disorganized synaptic connections, and glial function (or dysfunction).
authors.affiliation: Section of Epilepsy, Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. yingz@ccf.org
authors.forename: Zhong
authors.initials: Z
authors.lastname: Ying
authors.forename: Imad M
authors.initials: IM
authors.lastname: Najm
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology; D004195:Disease Models, Animal; D004828:Epilepsies, Partial / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D017981:Receptors, Neurotransmitter / Q000235:genetics
chemical_list: D017981:Receptors, Neurotransmitter