Genome instability: McClintock revisited.
Recent studies in yeast have shed light on the molecular mechanisms by which telomere dysfunction leads to chromosome fusions. Furthermore, examination of the consequences of telomerase loss in mice suggests that only a few critically short telomeres may be sufficient to promote genomic instability.
Lundblad
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Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. lundblad@bcm.tmc.edu
D004271:DNA, Fungal / Q000235:genetics; D016681:Genome, Fungal; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D016615:Telomere
D004271:DNA, Fungal