Involvement of the motor cortex in pseudochoreoathetosis.
The pathophysiological background of involuntary movements in pseudochoreoathetosis is unclear. We therefore recorded in four patients with pseudochoreoathetosis and in six age-matched controls cortical activity with a whole-head magnetoencephalography (MEG) system and surface EMGs from hand muscles. Subjects performed the following tasks: 1) rest, and 2) constant finger stretch during forearm elevation; controls additionally simulated pseudochoreoathetotic finger movements. During rest, the patients showed involuntary finger movements associated with excessive MEG-EMG coherence at frequencies between 6 and 20 Hz, whereas coherence in controls simulating pseudochoreoathetotic movements did not exceed noise level (P < 0.02). During finger stretch, MEG-EMG coherence in patients was similar to that of controls. Cortical sources of MEG-EMG coherence in patients were localized in the contralateral motor cortex. We conclude that pseudochoreoathetosis is associated with pathologically increased corticomuscular coherence and thus differs, neurophysiologically, from voluntarily simulated pseudochoreoathetotic movements. The enhanced MEG-EMG coherence in pseudochoreoathetosis probably reflects a pathologically strong motor cortical drive of spinal motorneurons after deafferentation.
Timmermann
L
L
Department of Neurology, Heinrich-Heine University, Duesseldorf, Germany.
Gross
J
J
Schmitz
F
F
Freund
H J
HJ
Schnitzler
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001264:Athetosis / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D002819:Chorea / Q000209:etiology* / Q000503:physiopathology; D004576:Electromyography; D005260:Female; D006225:Hand; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009046:Motor Neurons; D018482:Muscle, Skeletal / Q000503:physiopathology*; D011597:Psychomotor Performance; D012678:Sensation Disorders / Q000209:etiology