Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative.
The bis(S-pivaloyl-2-thioethyl) phosphotriester derivative of 9-(4'-hydroxy-1',2'-butadienyl)adenine (adenallene) was synthesized. This mononucleotide prodrug proved to be more effective than the parent nucleoside in inhibiting HIV-1 replication in several human T4 lymphoblastoid cell lines.
Egron
David
D
UMR CNRS 5625, Université Montpellier II, cc 008, Place E. Bataillon, 34095 Montpellier Cedex 5, France.
Périgaud
Christian
C
Gosselin
Gilles
G
Aubertin
Anne-Marie
AM
Gatanaga
Hiroyuki
H
Mitsuya
Hiroaki
H
Zemlicka
Jiri
J
Imbach
Jean-Louis
JL
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004952:Esters; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D004952:Esters; D018894:Reverse Transcriptase Inhibitors; C056909:adenallene; D000225:Adenine