Impact of the position of a gap on the response of the R1H-tumor of the rat on fractionated split-course radiotherapy.
BACKGROUND
Gaps are a common feature of clinical radiotherapy. Only little information is available about the influence of the position of a gap on tumor response.


METHODS
In a rodent tumor model (rhabdomyosarcoma R1H of the rat) three split-course schedules were carried out by inserting a 2-week gap either after the 1st, the 3rd, or the 5th week into a standard schedule of 30 fractions in 6 weeks. For comparison a standard and an accelerated treatment were carried out.


CONCLUSIONS
The position of the gap was found to have a significant influence on the tumor response (p = 0.018).
Zieron
J O
JO
Institute of Biophysics and Radiation Biology, University of Hamburg, Germany. Zieron@t-online.de
Omniczynski
M
M
Raabe
A
A
Beck-Bornholdt
H P
HP
D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D003238:Connective Tissue / Q000473:pathology; D019583:Dose Fractionation, Radiation; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D012208:Rhabdomyosarcoma / Q000473:pathology / Q000532:radiotherapy*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D014185:Transplantation, Isogeneic; D016896:Treatment Outcome