Oxidative stress in heart tissue of hyperthyroid and iron supplemented rats.
This study was designed to investigate the effect of hyperthyroidism and/or iron supplementation or cardiac oxidative stress parameters--the lipid peroxidation end product glutathione (GSH), glutathione peroxidase (CSH-Px), and superoxide dismutase (CuZnSOD)--in rats. In plasma, ferritin as an indicator of iron status and glutamate oxaloacetate transaminase (GOT) as an indicator of damage to the heart tissue were analyzed. Our findings show that hyperthyroidism increased lipooxidative damage as reflected by higher lipid peroxidation end product levels and elevated antioxidant defense parameters-GSH and GSH-Px. Iron supplementation per se does not affect oxidative stress parameters studied in the euthyroid state. Although iron increased lipid peroxidation in the hyperthyroid state, this effect was less than that seen in euthyroidism. Iron supplementation to hyperthyroid rats significantly lowered plasma ferritin levels, suggesting increased iron elimination with consequently reduced oxidative stress.
Civelek
S
S
Department of Biochemistry, Cerrahpaşa Medical Facility, Istanbul University, Turkey. bbseven@superonline.com.tr
Seymen
O
O
Seven
A
A
Yigit
G
G
Hatemi
H
H
Burçak
G
G
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005293:Ferritins / Q000097:blood; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D006980:Hyperthyroidism / Q000378:metabolism*; D007501:Iron / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015227:Lipid Peroxidation; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000032:analysis; D013963:Thyroid Hormones / Q000097:blood
D013963:Thyroid Hormones; D005293:Ferritins; D007501:Iron; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D005978:Glutathione