title: Influence of hyperbranched multi-methacrylates for dental neat resins on proliferation of human gingival fibroblasts.
abstract: We have previously shown that hyperbranched multi-methacrylate (H-MMA)-modified dental resins have VLC activities, lower polymerization shrinkage, and improved mechanical properties, compared to the 2,2-bis[4-(2-hydroxy-3-methacryloyolxypropoxy)phenyl]propane/triethyleneglycol dimethacrylate (BisGMA/TEGDMA) neat resin. The results are due to the unique molecular structure and high molecular weight of H-MMA intermediates. The purpose of this study was to evaluate the biocompatibility of H-MMA-modified dental neat resins. The cell proliferation of three human gingival fibroblast strains on either H-MMA, BisGMA/TEGDMA, or a polystyrene disk was examined. Following 10 days of cell proliferation, there was no statistical difference in cell number between H-MMA-modified and unmodified resin disks. H-MMA-modified resins had less free monomer leaching than the unmodified resin but showed similar properties in water sorption and contact angle values. All these results suggest that the biocompatibility of H-MMA-modified dental neat resins is as good as that of commercially used BisGMA/TEGDMA resin and H-MMA has potential applications in dental composites.
authors.affiliation: College of Dentistry, The Ohio State University, 305 West 12th Street, P.O. Box 182357, Columbus, Ohio 43218-2357, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Wan
authors.forename: D
authors.initials: D
authors.lastname: Rumpf
authors.forename: S R
authors.initials: SR
authors.lastname: Schricker
authors.forename: A
authors.initials: A
authors.lastname: Mariotti
authors.forename: B M
authors.initials: BM
authors.lastname: Culbertson
mesh_terms: D000328:Adult; D000368:Aged; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003764:Dental Materials / Q000009:adverse effects* / Q000737:chemistry*; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005881:Gingiva / Q000166:cytology*; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000009:adverse effects* / Q000737:chemistry*; D015394:Molecular Structure; D008970:Molecular Weight; D012117:Resins, Synthetic / Q000009:adverse effects* / Q000737:chemistry*; D014867:Water
chemical_list: D001672:Biocompatible Materials; D003764:Dental Materials; D008689:Methacrylates; D012117:Resins, Synthetic; D014867:Water