title: Regions responsible for organizing the microtubular cytoskeletons of extra-embryonic membranes.
abstract: We have identified putative microtubule-organising centres in whole mounts and frozen sections of full term human placenta, amniochorion and first trimester chorionic villus tissue by indirect immunofluorescence confocal laser scanning microscopy. These sites may perform a crucial executive role in the morphogenesis of human extra-embryonic membranes, and also may establish polarity in the amniotic epithelium and mediate the branching pattern of growth essential to the production of the chorionic villus tree.
authors.affiliation: University of Leicester and Warwick Medical School, UK.
authors.forename: P
authors.initials: P
authors.lastname: Hooper
authors.forename: S
authors.initials: S
authors.lastname: Byrne
authors.forename: C
authors.initials: C
authors.lastname: Ockleford
mesh_terms: D000650:Amnion / Q000737:chemistry / Q000648:ultrastructure*; D000941:Antigens / Q000032:analysis; D002823:Chorion / Q000737:chemistry / Q000648:ultrastructure*; D002824:Chorionic Villi / Q000648:ultrastructure; D003599:Cytoskeleton / Q000648:ultrastructure*; D005260:Female; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D006801:Humans; D008870:Microtubules / Q000648:ultrastructure*; D010920:Placenta / Q000648:ultrastructure; D011247:Pregnancy; D014404:Tubulin / Q000032:analysis
chemical_list: D000941:Antigens; D014404:Tubulin; C086178:pericentrin