[Anthelmintics as a risk factor in intestinal obstruction by Ascaris lumbricoides in children].
In a retrospective study the authors analyzed the clinical records of 199 children ages one month to 16 years hospitalized, with the diagnosis of intestinal ascariasis, in the Instituto Nacional de Pediatria of Mexico from 1984 to 1999. The purpose of the study was to evaluate the use of anthelmintics drugs as a risk factor of intestinal obstruction by A. lumbricoides. Two groups were made for the study: Group A (n = 66) of children who presented intestinal obstruction, Group B (n = 133) children with no complications. A comparative analysis of clinical data of both groups was made by means of chi square with Yates correction and a stratified analysis by means of chi square. Possible confusing elements were overcrowding, age and the use of antiparasitic drugs. The calculus of risk factors for intestinal obstruction by A. lumbricoides was done by means of contingency tables of 2 x 2 and odds ratio with an IC of 95%. The significant risk factors were included in a model of logistics regression with an impact variable consting in the presence or absence of intestinal obstruction in order to establish a multivariate model of predictive risk at level of significance of p < 0.05. Twenty-seven patients (40.90%) in group A (n = 66) were given anthelmintics medications prior to the intestinal obstruction: mebendazol, 14 (51-85%); two, albedazol (7.4%); eight, a non-specified anthelmintic (29.6%). In addition, an anthelmintic medication without a specified time of ingestion: two with mebendazol and one with piperazine (11.3%). In the case of mebendazol, the drug most frequently associated with intestinal obstruction, seven patients received it on the same day of the obstruction; five patients received it between one and seven days prior to the obstruction; two received it seven days prior to the complication. In the control group, only 7% had taken the anthelmintic one to seven days before the diagnosis of uncomplicated intestinal ascariasis diagnosis was made. With the step by step (Backward) logistic regression conditioned by the treatment variable with an anthelmintic, an X2 = 38.15 gl, p < 0.000 was obtained for which reason it was considered by A. lumbricoides. Of the probable risk factors analyzed in this study, the only one capable of influencing and predicting the presentation of intestinal obstruction by A. lumbricoides in children, was the prior anthelmintic treatment particularly with mebendazol.
Vásquez Tsuji
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Servicio de Parasitología y Micología, Instituto Nacional de Pediatría, Avenida Insurgentes Sur 3700.-C. Colonia Insurgentes Cuicuilco, Código Postal 04530, Delegación Coyoacán, México, Distrito Federal.
Gutiérrez Castrellón
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Yamazaki Nakashimada
M A
MA
Arredondo Suárez
J C
JC
Campos Riveral
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Martínez Barbosa
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I
D000293:Adolescent; D015766:Albendazole / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000009:adverse effects* / Q000627:therapeutic use; D001196:Ascariasis / Q000150:complications / Q000188:drug therapy*; D017164:Ascaris lumbricoides; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007415:Intestinal Obstruction / Q000139:chemically induced* / Q000469:parasitology; D016015:Logistic Models; D008297:Male; D008463:Mebendazole / Q000009:adverse effects / Q000627:therapeutic use; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors
D000871:Anthelmintics; D008463:Mebendazole; D015766:Albendazole