Monocyte chemotactic protein-1 in the vitreous of patients with proliferative diabetic retinopathy.
OBJECTIVE
To investigate the correlation between monocyte chemotactic protein-1 (MCP-1) levels in the vitreous and clinical findings in eyes with proliferative diabetic retinopathy (PDR).


METHODS
We assayed MCP-1 levels by ELISA in vitreous samples of 88 consecutive patients with PDR (52 eyes) and macular holes or idiopathic epimacular membrane (controls, 36 eyes).


RESULTS
The level of MCP-1 in the vitreous was 2,097.5 +/- 1,099.4 pg/ml (mean +/- SD) in PDR, and 504.3 +/- 405.6 pg/ml in the controls. In PDR eyes, multivariate regression analysis revealed a significant association between MCP-1 levels in the vitreous and the degree of proliferative membrane, and a significant negative association between MCP-1 levels and the extent of preoperative retinal photocoagulation.


CONCLUSIONS
The results suggest that MCP-1 may play a role in the development of the proliferative phase of PDR.
Mitamura
Y
Y
Department of Ophthalmology, Toho University Sakura Hospital, Sakura, Japan. ymita@sapmed.ac.jp
Takeuchi
S
S
Matsuda
A
A
Tagawa
Y
Y
Mizue
Y
Y
Nishihira
J
J
D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000378:metabolism*; D003930:Diabetic Retinopathy / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D019773:Epiretinal Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012167:Retinal Perforations / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism*
D018932:Chemokine CCL2