Urinary levels of nuclear matrix protein 22 in patients with urinary diversion.
OBJECTIVE
To evaluate the influence of various types of urinary diversion on urinary nuclear matrix protein 22 (U-NMP22) levels.


METHODS
U-NMP22 values were determined for 38 urinary diversion patients without upper urinary tract cancer. The patients were divided into three groups: tubeless cutaneous ureterostomy (n = 12), ileal conduit (n = 15), and continent urinary reservoir (n = 11). The mean values and false-positive rates of U-NMP22 (cutoff value 12 U/mL) were compared among the three groups.


RESULTS
The mean +/- standard error U-NMP22 value for the ureterostomy, ileal conduit, and reservoir groups was 20.1 +/- 5.8 U/mL, 335.6 +/- 63.5 U/mL, and 671.8 +/- 220.4 U/mL, respectively (P = 0.0030). The false-positive rate of U-NMP22 for the ureterostomy, ileal conduit, and reservoir groups was 41.7%, 100%, and 100%, respectively. In the ureterostomy group, the exclusion of patients with pyuria improved the false-positive rate of U-NMP22 from 41.7% to 12.5%.


CONCLUSIONS
U-NMP22 levels may be useful in the diagnosis of upper urinary tract cancer in patients with a tubeless cutaneous ureterostomy. However, in patients with urinary diversion using a bowel segment, U-NMP22 has no diagnostic value because of the high U-NMP22 levels.
Ishii
T
T
Department of Urology, Chikushi-Hospital, Fukuoka University, Chikushino, Japan
Okadome
A
A
Takeuchi
F
F
Hiratsuka
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000652:urine*; D016001:Confidence Intervals; D005189:False Positive Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000652:urine*; D014519:Ureterostomy; D001749:Urinary Bladder Neoplasms / Q000601:surgery / Q000652:urine*; D014547:Urinary Diversion; D016476:Urinary Reservoirs, Continent
D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; C100379:nuclear matrix protein 22