Cell biology. TAPping into mRNA export.
There seem to be numerous pathways for exporting mRNAs from the nucleus to the cytoplasm. But working out which set of export adaptors and receptors transport individual mRNAs has been very difficult. In a Perspective, Moore and Rosbash discuss a new strategy using cell-penetrating peptide inhibitors for unraveling the routes of mRNA export in living cells (Gallouzi and Steitz).
Moore
M J
MJ
Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA. mmoore@brandeis.edu
Rosbash
M
M
D000818:Animals; D051943:Antennapedia Homeodomain Protein; D000954:Antigens, Surface; D001692:Biological Transport / Q000187:drug effects; D002463:Cell Membrane Permeability; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism*; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; D005231:Fatty Acids, Unsaturated / Q000378:metabolism / Q000494:pharmacology; D015694:Gene Products, rev / Q000737:chemistry / Q000378:metabolism; D006678:HIV / Q000235:genetics; D018398:Homeodomain Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D028884:Karyopherins / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D029543:Nucleocytoplasmic Transport Proteins; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D014157:Transcription Factors; D054321:rev Gene Products, Human Immunodeficiency Virus; D000097606:Exportin 1 Protein
D051943:Antennapedia Homeodomain Protein; D000954:Antigens, Surface; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; D005231:Fatty Acids, Unsaturated; D015694:Gene Products, rev; D018398:Homeodomain Proteins; D028884:Karyopherins; D009479:Neuropeptides; D009687:Nuclear Proteins; D029543:Nucleocytoplasmic Transport Proteins; D010446:Peptide Fragments; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D054321:rev Gene Products, Human Immunodeficiency Virus; D000097606:Exportin 1 Protein; C490341:ANP32B protein, human; C098770:ELAVL1 protein, human; C122111:NXF1 protein, human; C038753:leptomycin B