Identification of a new human lens UV filter compound.
A new UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-diglucoside, has been identified in human lenses. The structure suggests that it is a further metabolic product of the second most abundant UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside. Quantification studies on the new compound show that it decreases towards zero in both the nucleus and cortex as a function of age. The discovery of this novel disaccharide completes the identification of the major UV filter compounds present in the human lens.
Taylor
L M
LM
Australian Cataract Research Foundation, University of Wollongong, NSW 2522, Australia.
Aquilina
J A
JA
Willis
R H
RH
Jamie
J F
JF
Truscott
R J
RJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002467:Cell Nucleus / Q000378:metabolism; D002648:Child; D002851:Chromatography, High Pressure Liquid; D005123:Eye / Q000378:metabolism; D005960:Glucosides / Q000096:biosynthesis* / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D007908:Lens, Crystalline / Q000737:chemistry*; D016014:Linear Models; D013058:Mass Spectrometry; D008875:Middle Aged; D008956:Models, Chemical; D010654:Phenylbutyrates / Q000737:chemistry* / Q000378:metabolism*; D013053:Spectrophotometry; D014466:Ultraviolet Rays
C444345:4-(2-amino-3-hydroxyphenyl)--4-oxobutanoic acid O-diglucoside; D005960:Glucosides; D010654:Phenylbutyrates; C088377:4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside