title: Pre-operative grading of intracranial glioma.
abstract: OBJECTIVE
  To compare the accuracy of MR-determined cerebral blood volume (CBV) maps with SPECT imaging with thallium-201 in pre-operative grading of intracranial glioma.
  
  
  METHODS
  Nineteen patients (7 female and 12 male, mean age 46.8 years) with intracranial gliomas were examined with MR perfusion imaging pre-operatively. Sixteen of these patients were also examined with SPECT imaging with thallium-201. The tumour to contralateral white matter NI (negative integral) and tracer uptake ratios were evaluated. The ratios in high-grade and low-grade tumours were compared.
  
  
  RESULTS
  The maximum CBV ratios of grades I and II gliomas (2.958+/-2.217) were significantly lower than the maximum CBV ratio of grades III and IV (9.484+/-4.520), p<0.001. There was no statistical difference when CBV ratios of grades I and II (p=0.381), grades II and III (p=0.229) and grades III and IV (p=0.476) gliomas were compared. Thallium SPECT imaging showed no difference in tumour uptake ratio between low-grade and high-grade gliomas (p=0.299).
  
  
  CONCLUSIONS
  MR-determined NI was useful for pre-operative grading of intracranial gliomas but SPECT thallium-201 imaging was not.
authors.affiliation: Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
authors.forename: W W
authors.initials: WW
authors.lastname: Lam
authors.forename: K W
authors.initials: KW
authors.lastname: Chan
authors.forename: W L
authors.initials: WL
authors.lastname: Wong
authors.forename: W S
authors.initials: WS
authors.lastname: Poon
authors.forename: C
authors.initials: C
authors.lastname: Metreweli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001810:Blood Volume / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012372:ROC Curve; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes