Metabolic gene polymorphism frequencies in control populations.
Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.
Garte
S
S
Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA.
Gaspari
L
L
Alexandrie
A K
AK
Ambrosone
C
C
Autrup
H
H
Autrup
J L
JL
Baranova
H
H
Bathum
L
L
Benhamou
S
S
Boffetta
P
P
Bouchardy
C
C
Breskvar
K
K
Brockmoller
J
J
Cascorbi
I
I
Clapper
M L
ML
Coutelle
C
C
Daly
A
A
Dell'Omo
M
M
Dolzan
V
V
Dresler
C M
CM
Fryer
A
A
Haugen
A
A
Hein
D W
DW
Hildesheim
A
A
Hirvonen
A
A
Hsieh
L L
LL
Ingelman-Sundberg
M
M
Kalina
I
I
Kang
D
D
Kihara
M
M
Kiyohara
C
C
Kremers
P
P
Lazarus
P
P
Le Marchand
L
L
Lechner
M C
MC
van Lieshout
E M
EM
London
S
S
Manni
J J
JJ
Maugard
C M
CM
Morita
S
S
Nazar-Stewart
V
V
Noda
K
K
Oda
Y
Y
Parl
F F
FF
Pastorelli
R
R
Persson
I
I
Peters
W H
WH
Rannug
A
A
Rebbeck
T
T
Risch
A
A
Roelandt
L
L
Romkes
M
M
Ryberg
D
D
Salagovic
J
J
Schoket
B
B
Seidegard
J
J
Shields
P G
PG
Sim
E
E
Sinnet
D
D
Strange
R C
RC
Stücker
I
I
Sugimura
H
H
To-Figueras
J
J
Vineis
P
P
Yu
M C
MC
Taioli
E
E
D044383:Black People / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D016208:Databases, Factual; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics*; D001741:Black or African American
D003577:Cytochrome P-450 Enzyme System