Developmental expression of the zinc finger transcription factor DRRF (dopamine receptor regulating factor).
Dopamine receptor regulating factor (DRRF) is a novel transcription factor with unique anatomical distribution and functional properties, suggesting its importance in regulating dopaminergic neurotransmission. To gain insight into the in vivo function of this factor during embryogenesis, we studied its distribution at embryonic days E8-E16 in the mouse using in situ hybridization. DRRF mRNA is expressed uniquely during development at all time points tested with high levels observed at E12, E14 and E16 in various tissues. DRRF expression is also found in particular brain regions, such as the neopallial cortex, olfactory lobe and corpus striatum. This pattern of DRRF distribution during embryogenesis overlaps with that found in the adult brain, and with the expression profile of dopamine receptors both in the adult and during development.
D'Souza
Ursula M
UM
Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1406, USA.
Lammers
Claas-Hinrich
CH
Hwang
Cheol Kyu
CK
Yajima
Shunsuke
S
Mouradian
M Maral
MM
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000196:embryology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D051741:Kruppel-Like Transcription Factors; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics
C486609:Klf16 protein, mouse; D051741:Kruppel-Like Transcription Factors; D012333:RNA, Messenger; D011954:Receptors, Dopamine; D014157:Transcription Factors