Caffeic acid phenethyl ester changes the indices of oxidative stress in serum of rats with renal ischaemia-reperfusion injury.
Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischaemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant properties. To investigate whether treatment with either CAPE or alpha-tocopherol modifies the levels of the endogenous indices of oxidant stress, we examined their effects on an in vivo model of renal ischaemia-reperfusion injury in rats. CAPE at 10 micromol kg(-1) or alpha-tocopherol at 10 mg kg(-1) was administered intraperitoneally before reperfusion. Acute administration of both CAPE and alpha-tocopherol altered the indices of oxidative stress differently in renal ischaemia-reperfusion injury.
Ozyurt
H
H
Department of Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey.
Irmak
M K
MK
Akyol
O
O
Söğüt
S
S
D000243:Adenosine Deaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects* / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D015427:Reperfusion Injury / Q000097:blood / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014969:Xanthine Oxidase / Q000097:blood; D024502:alpha-Tocopherol / Q000494:pharmacology
D000975:Antioxidants; D002109:Caffeic Acids; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde; D014969:Xanthine Oxidase; D000243:Adenosine Deaminase; C055494:caffeic acid phenethyl ester; D024502:alpha-Tocopherol; D010626:Phenylethyl Alcohol