A mercapto analogue of 5'-noraristeromycin.
5'-Noraristeromycin and its enantiomer have been found to possess a wide range of antiviral effects. In the search for analogues of and with improved activity, the synthesis of both enantiomers of 5'-mercapto-5'-deoxy-5'-noraristeromycin ( and ) has been accomplished. While (+)-7 was inactive, (-)- did show marginal activity against vaccinia virus, but not any other virus.
Das
Subha R
SR
Department of Chemistry, Auburn University, Auburn, AL 36849-5312, USA.
Schneller
Stewart W
SW
Balzarini
Jan
J
De Clercq
Erik
E
D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D004353:Drug Evaluation, Preclinical / Q000379:methods; D013329:Structure-Activity Relationship; D014616:Vaccinia virus / Q000187:drug effects
D000998:Antiviral Agents; C076829:5'-noraristeromycin; D000241:Adenosine