title: The genome of the natural genetic engineer Agrobacterium tumefaciens C58.
abstract: The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.
authors.affiliation: Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 357242, Seattle, WA 98195, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Wood
authors.forename: J C
authors.initials: JC
authors.lastname: Setubal
authors.forename: R
authors.initials: R
authors.lastname: Kaul
authors.forename: D E
authors.initials: DE
authors.lastname: Monks
authors.forename: J P
authors.initials: JP
authors.lastname: Kitajima
authors.forename: V K
authors.initials: VK
authors.lastname: Okura
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: G E
authors.initials: GE
authors.lastname: Wood
authors.forename: N F
authors.initials: NF
authors.lastname: Almeida
authors.forename: L
authors.initials: L
authors.lastname: Woo
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: I T
authors.initials: IT
authors.lastname: Paulsen
authors.forename: J A
authors.initials: JA
authors.lastname: Eisen
authors.forename: P D
authors.initials: PD
authors.lastname: Karp
authors.forename: D
authors.initials: D
authors.lastname: Bovee
authors.forename: P
authors.initials: P
authors.lastname: Chapman
authors.forename: J
authors.initials: J
authors.lastname: Clendenning
authors.forename: G
authors.initials: G
authors.lastname: Deatherage
authors.forename: W
authors.initials: W
authors.lastname: Gillet
authors.forename: C
authors.initials: C
authors.lastname: Grant
authors.forename: T
authors.initials: T
authors.lastname: Kutyavin
authors.forename: R
authors.initials: R
authors.lastname: Levy
authors.forename: M J
authors.initials: MJ
authors.lastname: Li
authors.forename: E
authors.initials: E
authors.lastname: McClelland
authors.forename: A
authors.initials: A
authors.lastname: Palmieri
authors.forename: C
authors.initials: C
authors.lastname: Raymond
authors.forename: G
authors.initials: G
authors.lastname: Rouse
authors.forename: C
authors.initials: C
authors.lastname: Saenphimmachak
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.forename: P
authors.initials: P
authors.lastname: Romero
authors.forename: D
authors.initials: D
authors.lastname: Gordon
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Yoo
authors.forename: Y
authors.initials: Y
authors.lastname: Tao
authors.forename: P
authors.initials: P
authors.lastname: Biddle
authors.forename: M
authors.initials: M
authors.lastname: Jung
authors.forename: W
authors.initials: W
authors.lastname: Krespan
authors.forename: M
authors.initials: M
authors.lastname: Perry
authors.forename: B
authors.initials: B
authors.lastname: Gordon-Kamm
authors.forename: L
authors.initials: L
authors.lastname: Liao
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: C
authors.initials: C
authors.lastname: Hendrick
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhao
authors.forename: M
authors.initials: M
authors.lastname: Dolan
authors.forename: F
authors.initials: F
authors.lastname: Chumley
authors.forename: S V
authors.initials: SV
authors.lastname: Tingey
authors.forename: J F
authors.initials: JF
authors.lastname: Tomb
authors.forename: M P
authors.initials: MP
authors.lastname: Gordon
authors.forename: M V
authors.initials: MV
authors.lastname: Olson
authors.forename: E W
authors.initials: EW
authors.lastname: Nester
mesh_terms: D016960:Agrobacterium tumefaciens / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D001422:Bacterial Adhesion / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002876:Chromosomes, Bacterial / Q000235:genetics; D003227:Conjugation, Genetic; D004261:DNA Replication; D005798:Genes, Bacterial; D005809:Genes, Regulator; D016680:Genome, Bacterial; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D010944:Plants / Q000382:microbiology; D010957:Plasmids; D012093:Replicon; D012230:Rhizobiaceae / Q000235:genetics / Q000502:physiology; D017422:Sequence Analysis, DNA; D016962:Sinorhizobium meliloti / Q000235:genetics / Q000502:physiology; D013559:Symbiosis; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins