title: Complete regression of colonic adenomas after treatment with sulindac in Gardner's syndrome: a 4-year follow-up.
abstract: A 22-year-old woman with Gardner's syndrome in whom long-term sulindac therapy, without surgical treatment, was effective in inducing complete regression of colonic adenomas is reported. One hundred milligrams of sulindac was administered twice daily after endoscopic polypectomy. Follow-up colonoscopy 6 months later revealed an encouraging regression of colonic adenomas. The tumors had disappeared after 40 months of sulindac treatment. A sustained effect was identified even after 51 months. Ten milligrams of famotidine was coadministered to prevent side effects of sulindac. Although the effect of sulindac on colorectal adenomas may be transient, this therapy may be useful for postponing prophylactic colectomy, especially for the sparse type of familial adenomatous polyposis.
authors.affiliation: Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Okai
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: J
authors.initials: J
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Ohtsubo
authors.forename: H
authors.initials: H
authors.lastname: Mouri
authors.forename: N
authors.initials: N
authors.lastname: Sawabu
mesh_terms: D000236:Adenoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005736:Gardner Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D011859:Radiography; D012074:Remission Induction; D012886:Skull / Q000000981:diagnostic imaging; D013467:Sulindac / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D013467:Sulindac