title: High frequency of mutator strains among human uropathogenic Escherichia coli isolates.
abstract: By using a panel of 603 commensal and pathogenic Escherichia coli and Shigella isolates, we showed that mutation rates of strains vary considerably among different ecotypes. Uropathogenic strains had the highest frequency of mutators, while strains from patients with bacteremia had the lowest mutation rates. No correlation between the mutation rates and antibiotic resistance was observed among the studied strains.
authors.affiliation: INSERM U 458, Hôpital Robert, Debré, Paris, France.
authors.forename: Erick
authors.initials: E
authors.lastname: Denamur
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonacorsi
authors.forename: Antoine
authors.initials: A
authors.lastname: Giraud
authors.forename: Patrick
authors.initials: P
authors.lastname: Duriez
authors.forename: Farida
authors.initials: F
authors.lastname: Hilali
authors.forename: Christine
authors.initials: C
authors.lastname: Amorin
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
authors.forename: Antoine
authors.initials: A
authors.lastname: Andremont
authors.forename: Bertrand
authors.initials: B
authors.lastname: Picard
authors.forename: François
authors.initials: F
authors.lastname: Taddei
authors.forename: Ivan
authors.initials: I
authors.lastname: Matic
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology*; D014644:Genetic Variation; D006801:Humans; D009154:Mutation; D012760:Shigella / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents