title: Pemphigus vulgaris: environmental factors. Occupational, behavioral, medical, and qualitative food frequency questionnaire.
abstract: BACKGROUND
  There have been reports suggesting the involvement of environmental factors in the disease process of pemphigus. Factors suggested include exposure to pesticides or certain drugs.
  
  
  OBJECTIVE
  To analyze the association of pemphigus with environmental exposure to various agents, including smoking, recreational and occupational insults, drugs, and food.
  
  
  METHODS
  In-person interviews of pemphigus patients and control subjects were conducted by trained medical investigators using a structured questionnaire. Questions included occupational, behavioral, medical, and qualitative food frequency details. The multicenter study was conducted at outpatient services of teaching hospitals in Bulgaria, Brazil, India, Israel, Italy, Spain, and the USA.
  
  
  METHODS
  A total of 126 pemphigus patients (55 men, 71 women; age, 54 +/- 17 years) and 173 healthy controls (87 men, 86 women; age 50 +/- 19 years) were interviewed in the period between October 1, 1999 and March 31, 2000. The diagnosis of pemphigus was based on clinical, histologic, immunohistologic, and immunohistochemical criteria. The disease duration was 2-27 years (8.4 +/- 7.2 years). Individuals with skin diseases other than pemphigus were selected as control subjects.
  
  
  METHODS
  Information on drugs, foods, and occupational, environmental, constitutional, and other possible risk factors was analyzed by t-tests and chi-squared tests as applicable. A multivariate logistic regression model was applied to the data to study simultaneously the independent relationship between each risk factor and pemphigus vulgaris.
  
  
  RESULTS
  The risk for pemphigus vulgaris was lower for ex-smokers and current smokers than for patients who had never smoked. Exposure to pesticides and occupational exposure to metal vapor were associated with an increased risk of pemphigus. Pemphigus patients had more pregnancies than controls. There were differences in environmental factors between countries, with exposure to gardening materials and pesticides being highest among patients from Bulgaria, followed by Israel. Disease characteristics also exhibited differences between countries. Bulgarian patients less frequently had oral mucous membrane lesions: 66% compared to 92% for Israeli patients and 83% for Italians. The distribution of the disease in skin and mucous membranes was similar among patients from all countries. Exclusive skin involvement was seen in 50% of patients, mucous membranes alone in 23% of patients, and both skin and mucous membranes in 27% of patients.
  
  
  CONCLUSIONS
  The beneficial effect of smoking on pemphigus might be explained by its effect on the immune system. In addition, smoking has an antiestrogenic effect, while pesticides have an estrogenic effect. The lower numbers of smokers among patients, the higher exposure rates to pesticides, and the higher number of female patients who had been pregnant may point to the contribution of estrogens to the disease process. It remains to be determined whether measures, such as avoiding exposure to pesticides or metal vapor, may be beneficial in the clinical context. As the present study was a survey, more definitive studies should be conducted to validate the results.
authors.affiliation: Department of Dermatology, Tel Aviv Elias Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. derma@tasmc.health.gov.il
authors.forename: S
authors.initials: S
authors.lastname: Brenner
authors.forename: E
authors.initials: E
authors.lastname: Tur
authors.forename: J
authors.initials: J
authors.lastname: Shapiro
authors.forename: V
authors.initials: V
authors.lastname: Ruocco
authors.forename: M
authors.initials: M
authors.lastname: D'Avino
authors.forename: E
authors.initials: E
authors.lastname: Ruocco
authors.forename: N
authors.initials: N
authors.lastname: Tsankov
authors.forename: S
authors.initials: S
authors.lastname: Vassileva
authors.forename: K
authors.initials: K
authors.lastname: Drenovska
authors.forename: P
authors.initials: P
authors.lastname: Brezoev
authors.forename: M A
authors.initials: MA
authors.lastname: Barnadas
authors.forename: M J
authors.initials: MJ
authors.lastname: Gonzalez
authors.forename: G
authors.initials: G
authors.lastname: Anhalt
authors.forename: H
authors.initials: H
authors.lastname: Nousari
authors.forename: M
authors.initials: M
authors.lastname: Ramos-e-Silva
authors.forename: K T
authors.initials: KT
authors.lastname: Pinto
authors.forename: M F
authors.initials: MF
authors.lastname: Miranda
authors.forename: M R
authors.initials: MR
authors.lastname: Silva
mesh_terms: D000383:Agriculture; D002031:Bulgaria; D004032:Diet; D004781:Environmental Exposure; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010392:Pemphigus / Q000209:etiology* / Q000473:pathology; D010575:Pesticides / Q000009:adverse effects; D012307:Risk Factors; D012907:Smoking; D013315:Stress, Psychological / Q000150:complications; D011795:Surveys and Questionnaires
chemical_list: D010575:Pesticides