Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.
The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces gamma-aminobutyric acid (GABA) reuptake and enhances GABA transmission and may thus alleviate dyskinesia. In a randomized, double-blind, placebo-controlled, crossover trial (n = 7), the authors demonstrate that the cannabinoid receptor agonist nabilone significantly reduces levodopa-induced dyskinesia in PD.
Sieradzan
K A
KA
Department of Neurology, Manchester Royal Infirmary, UK.
Fox
S H
SH
Hill
M
M
Dick
J P
JP
Crossman
A R
AR
Brotchie
J M
JM
D000368:Aged; D000818:Animals; D018592:Cross-Over Studies; D046508:Culture Techniques; D004311:Double-Blind Method; D013759:Dronabinol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005917:Globus Pallidus / Q000187:drug effects; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000819:agonists*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; C011941:nabilone; D007980:Levodopa; D005680:gamma-Aminobutyric Acid; D013759:Dronabinol