title: Are goats naturally resistant to gastric Helicobacter infection?
abstract: Gastric Helicobacter species are widespread and have been reported in wild and domestic mammals of different dietary habits such as humans, dogs, cats, macaques, mice, cheetahs, ferrets, swine and cattle. All have been associated with gastric pathologies. Recently, gastric Helicobacter species were shown to be widespread in cattle and swine in Europe, and there is a report of Helicobacter pylori in sheep in Italy. However, there are no reports of Helicobacter infection in the goat, another important domestic animal of human consumption. The aim of our study was to assess whether Helicobacter abomasal infection was common in goats slaughtered for human consumption. Infection was detected through PCR analysis of DNA extracted from gastric biopsies, using genus- and species-specific primers. Bovine and porcine gastric samples were also analyzed as positive controls. None of the 70 goats were positive for Helicobacter spp.; however, Candidatus Helicobacter bovis and Candidatus Helicobacter suis were detected in 85% of the bovine and 45% of the porcine samples, respectively. We discuss the possibility that goats may exhibit natural resistance to abomasal infection by Helicobacter spp.
authors.affiliation: Laboratorio de Fisiología Gastrointestinal, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela. pgueneau@cbb.ivic.ve
authors.forename: Pulchérie
authors.initials: P
authors.lastname: Gueneau
authors.forename: Jahely
authors.initials: J
authors.lastname: Fuenmayor
authors.forename: Olga C
authors.initials: OC
authors.lastname: Aristimuño
authors.forename: Samandhy
authors.initials: S
authors.lastname: Cedeño
authors.forename: Estalina
authors.initials: E
authors.lastname: Báez
authors.forename: Nelson
authors.initials: N
authors.lastname: Reyes
authors.forename: Fabián
authors.initials: F
authors.lastname: Michelangeli
authors.forename: Maria Gloria
authors.initials: MG
authors.lastname: Domínguez-Bello
mesh_terms: D000018:Abomasum / Q000382:microbiology / Q000473:pathology; D000818:Animals; D001706:Biopsy / Q000662:veterinary; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000382:microbiology; D017931:DNA Primers; D004269:DNA, Bacterial / Q000032:analysis; D015511:Goat Diseases / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D006041:Goats; D016998:Helicobacter / Q000145:classification / Q000472:pathogenicity*; D016481:Helicobacter Infections / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D007113:Immunity, Innate; D008297:Male; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013272:Stomach Diseases / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000382:microbiology
chemical_list: D017931:DNA Primers; D004269:DNA, Bacterial