title: Anaplastic meningioma: case report.
abstract: Intracranial meningiomas continue to challenge our best clinical efforts to eliminate them once discovered and deemed appropriate for treatment. Malignant meningiomas constitute 10% to 15% of all meningiomas and limited information exists regarding adjuvant treatment. The external whole brain irradiation is recommended. Traditional chemotherapy has proven ineffective; thus, new chemotherapeutic agents and new methods of delivery should be developed. Immunotherapy may be considered for patients with malignant meningiomas when all others previous treatment have failed. We report a case of anaplastic papillary meningioma. A 67-year-old man presented with partial complex seizures, headache and aggressiveness. A computerized tomography and magnetic resonance image demonstrated a large left temporo-occipital mass with diffuse contrast enhancement and extensive surrounding edema. A left temporo-occipital flap was performed. The tumor and the infiltrated dura were radically removed. Postoperatively, the patient remained neurologically intact. The treatment was complemented by external whole brain radiation.
authors.affiliation: Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, SP, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Falavigna
authors.forename: J A
authors.initials: JA
authors.lastname: Santos
authors.forename: L
authors.initials: L
authors.lastname: Chimelli
authors.forename: F A
authors.initials: FA
authors.lastname: Ferraz
authors.forename: A de P
authors.initials: Ade P
authors.lastname: Bonatelli Ad
mesh_terms: D000368:Aged; D006801:Humans; D007167:Immunotherapy; D008297:Male; D008577:Meningeal Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D008579:Meningioma / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*