Control of growth and development of the feto-placental unit.
Classical gene targeting has identified many genes important for fetal and placental development. Null mutation of these genes may lead to fetal growth restriction, malformation or embryonic death. Growth restriction of epigenetic basis can predispose to adult-onset diseases. The mechanisms underlying this process, termed 'fetal programming', are beginning to be understood.
Han
V K
VK
CIHR Group in Fetal and Neonatal Health and Development, Lawson Health Research Institute and Child Health Research Institute, University of Western Ontario, London, Canada. vhan@uwo.ca
Carter
A M
AM
D000818:Animals; D002319:Cardiovascular System / Q000196:embryology; D005314:Embryonic and Fetal Development / Q000235:genetics*; D004703:Endocrine System / Q000196:embryology; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D005821:Genetic Techniques; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000502:physiology; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000502:physiology; D020738:Leptin / Q000235:genetics / Q000502:physiology; D051379:Mice; D010920:Placenta / Q000098:blood supply / Q000196:embryology*; D011247:Pregnancy
D005938:Glucocorticoids; D020738:Leptin; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II