title: Doppler quantitative measures by region to discriminate prostate cancer.
abstract: This study was conducted to assess if sonographic discrimination between healthy and cancerous prostate tissue might be improved using regional analysis of ultrasound (US) Doppler measures. A total of 39 subjects underwent 3-D Doppler sonography before radical prostatectomy. Cancer locations were identified from hematoxylin and eosin (H&E)-stained slides. Three prostate data volumes consisting of a frequency shift and power-mode Doppler US and whole mount histology images were spatially registered for each prostate, then divided into entirely 1 mL-sized regions of cancerous or noncancerous tissue. Each prostate was visually divided into a peripheral and a periurethral region within which US Doppler measures were calculated. Receiver operating characteristic (ROC) and simulated biopsy analyses within each prostate were performed. Mean speed in colored pixels (V), and speed-weighted pixel density (SWD) are good discriminators for prostate cancer in the periurethral and the peripheral regions, respectively. Using SWD in a simulated biopsy yields increased cancer detection in the peripheral region.
authors.affiliation: University of Michigan, Department of Radiology, Kresge III Room 3316, Ann Arbor, MI 48109-0553, USA. titainap@hotmail.com
authors.forename: T C
authors.initials: TC
authors.lastname: Potdevin
authors.forename: A P
authors.initials: AP
authors.lastname: Moskalik
authors.forename: J B
authors.initials: JB
authors.lastname: Fowlkes
authors.forename: R O
authors.initials: RO
authors.lastname: Bude
authors.forename: P L
authors.initials: PL
authors.lastname: Carson
mesh_terms: D000368:Aged; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012372:ROC Curve; D018615:Ultrasonography, Doppler, Color