title: 17beta-Estradiol increases, aging decreases, c-Fos expression in the rat accessory olfactory bulb.
abstract: In the present paper we investigated the c-Fos immunoreactivity in the accessory olfactory bulb (AOB) of juvenile, adult and old rats of both sexes, as well as the effect of 17beta-estradiol on the expression of this immediate early gene. Basal c-Fos expression in the olfactory bulb decreased with age, and estrogen treatment caused an increase in the number of neurons expressing c-Fos in the AOB. The results indicate that both aging and estrogen have roles in the ability of neurons to co-ordinate genetic activity. Our observations may explain the decrease in age-related changes of brain plasticity, and provide data for the understanding of hormonally regulated neuronal plasticity.
authors.affiliation: Molecular Neurobiology Laboratory, Institute of Biophysics, Biological Research Center, 6701 Szeged, P.O. Box 521, Hungary.
authors.forename: J A
authors.initials: JA
authors.lastname: Balog
authors.forename: A
authors.initials: A
authors.lastname: Kurunczi
authors.forename: A
authors.initials: A
authors.lastname: Párducz A
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology; D004958:Estradiol / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009830:Olfactory Bulb / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects / Q000502:physiology; D012724:Sex Attractants / Q000378:metabolism; D012727:Sex Characteristics; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D012724:Sex Attractants; D004958:Estradiol