Subtle prefrontal neuropathology in a pilot magnetic resonance spectroscopy study in patients with borderline personality disorder.
The authors examined the brains of patients with borderline personality disorder (BPD) by using short echo time single voxel spectroscopy and found a significant 19% reduction of absolute N-acetylaspartate concentrations in the dorsolateral prefrontal cortex in BPD (P=0.01) compared with control subjects.
van Elst
L T
LT
Department of Psychiatry and Psychotherapy, Albert-Ludwigs-University, Freiburg, Germany. ludger_vanelst@psyallg.ukl.uni-freiburg.de
Thiel
T
T
Hesslinger
B
B
Lieb
K
K
Bohus
M
M
Hennig
J
J
Ebert
D
D
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D001883:Borderline Personality Disorder / Q000175:diagnosis* / Q000473:pathology; D001931:Brain Mapping; D003342:Corpus Striatum / Q000473:pathology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D017397:Prefrontal Cortex / Q000473:pathology*; D012016:Reference Values
D001786:Blood Glucose; D001224:Aspartic Acid; C000179:N-acetylaspartate