Lack of association between a polymorphism in the promoter region of the dopamine D2 receptor and personality traits.
Disturbances of the dopaminergic neurotransmitter system have been associated with a personality trait that involves novelty seeking. A functional polymorphism in the promoter region of the dopamine D2 receptor gene (DRD2) has been reported to be associated with schizophrenia. We examined the association between this polymorphism in the DRD2 promoter region and personality traits, as assessed with the Tridimensional Personality Questionnaire. No significant association emerged between the polymorphism in the DRD2 promoter region and personality traits. Entering sex and age as covariates in an analysis of covariance did not change the results. These data fail to confirm an association between a polymorphism in the promoter region of the DRD2 and personality traits.
Katsuragi
S
S
Department of Neuropsychiatry, Oita Medical University, Hasama-Machi, 879-5593, Oita, Japan.
Kiyota
A
A
Tsutsumi
T
T
Isogawa
K
K
Nagayama
H
H
Arinami
T
T
Akiyoshi
J
J
D000328:Adult; D000483:Alleles; D001143:Arousal / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012016:Reference Values
D017448:Receptors, Dopamine D2