Organellar peptide deformylases: universality of the N-terminal methionine cleavage mechanism.
Most mature proteins do not retain their initial N-terminal amino acid (methionine in the cytosol and N-formyl methionine in the organelles). Recent studies have shown that dedicated machinery is involved in this process in plants. In addition to cytosolic and organelle-targeted methionine aminopeptidases, organellar peptide deformylases have been identified. Here, we attempt to answer questions about the mechanism, specificity and significance of N-terminal methionine cleavage in plant organelles. It seems to be universal because orthologues of plant deformylases are found in most living organisms.
Giglione
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Institut des Sciences du Végétal, UPR2355, Centre National de la Recherche Scientifique, Bâtiment 23, 1 avenue de la Terrasse, F-91198 Gif-sur-Yvette Cedex, France. meinnel@isv.cnrs-gif.fr
Meinnel
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D000581:Amidohydrolases; D000626:Aminopeptidases / Q000378:metabolism*; D002736:Chloroplasts / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D019143:Evolution, Molecular; D008715:Methionine / Q000378:metabolism*; D015388:Organelles / Q000201:enzymology*; D010940:Plant Proteins / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
D010940:Plant Proteins; D008715:Methionine; D000626:Aminopeptidases; D000581:Amidohydrolases; C084507:peptide deformylase