Effects of chronic intake of vegetable protein added to animal or fish protein on renal hemodynamics.
OBJECTIVE
To examine whether chronic intake of vegetable protein added to animal protein diet affects renal hemodynamics or not, we studied effects of three kinds of diets containing various amounts of animal and vegetable protein with 1-week dietary program in each on renal hemodynamics.


METHODS
The crossover design of different amounts of vegetable protein added to the constant amount of animal protein was applied to two groups of 7 healthy individuals after the control dietary program. Renal function and 24 hours' urinary albumin excretion rate (AER) were examined on every 7th day of three consecutive 1-week dietary programs.


RESULTS
Glomerular filtration rate (GFR; sodium thiosulphate clearance) and renal plasma flow (RPF) significantly decreased after decreasing the intake of animal protein by one third with keeping the amount of vegetable protein constant. The results when substituting vegetable protein for some of the animal protein in the diet without changing the total amount of protein were identical. The filtration fraction and AER did not change over the study periods regardless of dietary composition.


CONCLUSIONS
The lack of an effect a 1-week intake of vegetable protein added to animal protein on GFR and RPF suggests that vegetable protein may be excluded from lists of restriction in low protein diet therapy in patients with renal insufficiency.
Kitazato
Hiroji
H
Division of Geriatric Medicine, Akita University Hospital, Akita, Japan.
Fujita
Hiroki
H
Shimotomai
Takashi
T
Kagaya
Eri
E
Narita
Takuma
T
Kakei
Masafumi
M
Ito
Seiki
S
D000328:Adult; D018592:Cross-Over Studies; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D005919:Glomerular Filtration Rate; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D008460:Meat; D014674:Plant Proteins, Dietary / Q000008:administration & dosage*; D017595:Renal Plasma Flow; D014556:Urine / Q000737:chemistry
D004044:Dietary Proteins; D014674:Plant Proteins, Dietary