title: The Histone Database.
abstract: Histone proteins are often noted for their high degree of sequence conservation. It is less often recognized that the histones are a heterogeneous protein family. Furthermore, several classes of non-histone proteins containing the histone fold motif exist. Novel histone and histone fold protein sequences continue to be added to public databases every year. The Histone Database (http://genome.nhgri.nih.gov/histones/) is a searchable, periodically updated collection of histone fold-containing sequences derived from sequence-similarity searches of public databases. Sequence sets are presented in redundant and non-redundant FASTA form, hotlinked to GenBank sequence files. Partial sequences are also now included in the database, which has considerably augmented its taxonomic coverage. Annotated alignments of full-length non-redundant sets of sequences are now available in both web-viewable (HTML) and downloadable (PDF) formats. The database also provides summaries of current information on solved histone fold structures, post-translational modifications of histones, and the human histone gene complement.
authors.affiliation: Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 45, Room 6AN12J, 45 Center Drive, MSC 6510, Bethesda, MD 20892-6510, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Sullivan
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Sink
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Trout
authors.forename: Izabela
authors.initials: I
authors.lastname: Makalowska
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Taylor
authors.forename: Andreas D
authors.initials: AD
authors.lastname: Baxevanis
authors.forename: David
authors.initials: D
authors.lastname: Landsman
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000235:genetics; D030562:Databases, Protein; D014644:Genetic Variation; D006657:Histones / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D016415:Sequence Alignment; D017385:Sequence Homology
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D006657:Histones