title: Eruptive syringomas with calcium deposits in a young woman with Down's syndrome.
abstract: Eruptive syringomas are uncommon in the general population. We describe here an 18-year-old female, affected by Down's syndrome, who presented with an abrupt eruption of small skin-colored or reddish papules on the face, neck and limbs. Light microscopy allowed us to diagnose syringomas, whereas the study of the ultrastructural features revealed calcium deposits in many lumina and also in the mitochondria. This observation confirms the hypothesis that the syringeal structure plays a role in the pathogenesis of calcinosis cutis.
authors.affiliation: Unit of Dermatology, Oasi Institute (IRCCS), Troina, Italy. underm@oasi.en.it
authors.forename: C
authors.initials: C
authors.lastname: Schepis
authors.forename: V
authors.initials: V
authors.lastname: Torre
authors.forename: M
authors.initials: M
authors.lastname: Siragusa
authors.forename: F
authors.initials: F
authors.lastname: Albiero
authors.forename: R
authors.initials: R
authors.lastname: Cicciarello
authors.forename: M E
authors.initials: ME
authors.lastname: Gagliardi
authors.forename: V
authors.initials: V
authors.lastname: Cavallari
mesh_terms: D000293:Adolescent; D002114:Calcinosis / Q000150:complications / Q000473:pathology*; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D009333:Neck / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000150:complications / Q000473:pathology*; D018252:Syringoma / Q000150:complications / Q000473:pathology*