title: Response characteristics of cutaneous mechanoreceptors in neuropathic rats.
abstract: The activity of single myelinated afferents was recorded from dorsal roots L4-5 in normal Sprague-Dawley rats and animals that developed mechanical hypersensitivity following ischemic injury to the sciatic nerve. The mechanical response properties and conduction velocity of afferents conducting through the injury site (about 50% of units) were similar to controls. However, the majority of afferents not conducting through the injury site exhibited ongoing activity. The results suggest that mechanical allodynia may be at least partly due to the central integration of activity arising from these two populations of afferents in neuropathic rats.
authors.affiliation: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institutet, Huddinge University Hospital, S-141 86 Stockholm, Sweden.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Bulka
authors.forename: Jing Xia
authors.initials: JX
authors.lastname: Hao
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Wiesenfeld-Hallin
mesh_terms: D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D004923:Erythrosine / Q000633:toxicity; D005727:Ganglia, Spinal / Q000503:physiopathology; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology*; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology; D007834:Lasers; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D009412:Nerve Fibers / Q000145:classification / Q000502:physiology; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D009431:Neural Conduction; D017288:Pain Threshold / Q000502:physiology*; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000098:blood supply / Q000293:injuries; D012585:Sciatica / Q000209:etiology / Q000503:physiopathology*; D012867:Skin / Q000294:innervation*; D014110:Touch / Q000502:physiology
chemical_list: D017319:Photosensitizing Agents; D004923:Erythrosine