title: The effect of flurbiprofen and tiaprofenic acid on serum cytokine levels of patients with osteoarthrosis.
abstract: 39 patients with active knee osteoarthrosis, chosen according to ACR criteria, were assigned to receive flurbiprofen (n 12, 2 x 100 mg), tiaprofenic acid (n 14, 2 x 300 mg) and placebo (n 13) in a 3-week, placebo-controlled study. All patients completed the study, and both medications were found to be effective: improvement occurred in the clinical signs. These drugs reduced the TNF-alpha levels. Flurbiprofen especially affected the IL-6 levels. Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis.
authors.affiliation: Cerahpasa Medical Faculty, University of Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Uzun
authors.forename: S
authors.initials: S
authors.lastname: Tuzun
authors.forename: N
authors.initials: N
authors.lastname: Ozaras
authors.forename: S
authors.initials: S
authors.lastname: Aydin
authors.forename: R
authors.initials: R
authors.lastname: Ozaras
authors.forename: S
authors.initials: S
authors.lastname: Dondurmaci
authors.forename: F
authors.initials: F
authors.lastname: Tuzun
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood*; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000188:drug therapy*; D010147:Pain Measurement; D011422:Propionates / Q000627:therapeutic use*; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D011422:Propionates; D014409:Tumor Necrosis Factor-alpha; C021270:tiaprofenic acid; D005480:Flurbiprofen