Prognostic significance of thymidine phosphorylase and p53 co-expression in esophageal squamous cell carcinoma.
This study investigated the prognostic significance of thymidine phosphorylase (TP) and p53 expression in 96 surgically resected primary esophageal squamous cell carcinomas. Expression was assessed using immunohistochemical staining methods. Prognostic values were determined by multivariate analysis using Cox's proportional hazards model. Although TP expression was not correlated with p53 expression, it was associated with genetic alteration of the latter. In univariate analysis, TP expression emerged as a significant prognostic factor but p53 expression did not. However, in multivariate analysis, despite TP not being a significant independent predictor of survival, co-expression of TP together with p53 did represent a statistically significant prognostic factor.
Makoto
Oota
O
Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Takeda
Akihiko
A
Ting-Leig
Leu
L
Shinnichi
Okazumi
O
Hisahiro
Matsubara
M
Yutaka
Funami
F
Yoshihiro
Nabeya
N
Kobayashi
Susumu
S
Gunji
Yoshio
Y
Suzuki
Takao
T
Takenori
Ochiai
O
Hideaki
Shimada
S
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000201:enzymology*; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D011379:Prognosis; D016019:Survival Analysis; D013939:Thymidine Phosphorylase / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53; D013939:Thymidine Phosphorylase