Analysis of over-the-counter dietary supplements.
OBJECTIVE
To determine if steroids containing over-the-counter (OTC) dietary supplements conform to the labeling requirements of the 1994 Dietary Supplement Health and Education Act (DSHEA).


METHODS
12 brands of OTC supplements containing 8 different steroids were randomly selected for purchase in stores that cater to athletes. There are two androstenediones (4- and 5-androstene-3,17-dione), two androstenediols (4- and 5-androstene-3beta, 17beta-diol), and 4 more are 19-nor cogeners (19-nor-4- and 5-androstene-3,17-dione and 19-nor-4- and 5-androstene-3beta, 17beta-diol).


METHODS
12 brands of OTC anabolic-androgenic supplements were analyzed by high-pressure liquid chromatography.


RESULTS
We found that 11 of 12 brands tested did not meet the labeling requirements set out in the 1994 Dietary Supplement Health and Education Act. One brand contained 10 mg of testosterone, a controlled steroid, another contained 77% more than the label stated, and 11 of 12 contained less than the amount stated on the label.


CONCLUSIONS
These mislabeling problems show that the labels of the dietary steroid supplements studied herein cannot be trusted for content and purity information. In addition, many sport organizations prohibit OTC steroids; thus, athletes who use them are at risk for positive urine test results. In this article we provide the details of the analyses, a summary of the steroids by name and structure, and information on the nature of the positive test results. Athletes and their physicians need this information because of the potential medical consequences and positive urine test results.
Green
G A
GA
Department of Family Medicine, Division of Sports Medicine, University of California at Los Angeles, 90095-7087, USA. green@mednet.ucla.edu
Catlin
D H
DH
Starcevic
B
B
D019587:Dietary Supplements / Q000032:analysis* / Q000592:standards*; D004300:Doping in Sports / Q000379:methods; D006801:Humans; D007881:Legislation, Food; D004366:Nonprescription Drugs / Q000032:analysis* / Q000592:standards*; D011356:Product Labeling / Q000331:legislation & jurisprudence* / Q000592:standards; D011358:Product Surveillance, Postmarketing; D011786:Quality Control; D013256:Steroids / Q000032:analysis* / Q000737:chemistry / Q000592:standards* / Q000652:urine; D014481:United States; D016482:Urinalysis / Q000592:standards
D004366:Nonprescription Drugs; D013256:Steroids