title: Post-traumatic fibro-osseous lesion of the ribs and scapula (sclerosing xanthofibroma).
abstract: Fibrous lesions of bone may be difficult to classify. Their etiology is controversial, most being considered to be developmental lesions rather than true neoplasms. We describe a patient with post-traumatic fibro-osseous lesion of the ribs, also known as sclerosing xanthofibroma; a lesion believed to be a reactive response to intramedullary hemorrhage following chest wall trauma. Clinically, the lesions in our patient were thought to be metastatic disease because of their multifocal appearance. An extensive clinical and laboratory metastatic evaluation with surgical resection of one of the lesions using intraoperative gamma probe was undertaken. In addition to the multiple rib involvement, our case also showed a lesion in the scapula. The pathologic and radiologic features of this entity are reviewed along with the summary of the differential diagnosis.
authors.affiliation: Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Greater Miami, Miami Beach, FL 33140, USA.
authors.forename: M
authors.initials: M
authors.lastname: Blanco
authors.forename: B
authors.initials: B
authors.lastname: Cabello-Inchausti
authors.forename: M
authors.initials: M
authors.lastname: Cura
authors.forename: L
authors.initials: L
authors.lastname: Fernandes
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001859:Bone Neoplasms / Q000556:secondary; D003937:Diagnosis, Differential; D005359:Fibrous Dysplasia, Polyostotic / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D005487:Foam Cells / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012272:Ribs / Q000000981:diagnostic imaging / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D012540:Scapula / Q000000981:diagnostic imaging / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D014746:Vimentin / Q000032:analysis; D014947:Wounds and Injuries; D014973:Xanthomatosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule