Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications.
To elucidate the relationship between the thromboxane A2/prostacyclin (TXA2/PGI2) ratio and diabetic complications, the levels of 11-dehydro-thromboxane B2 and 2,3-dinor-6-keto-prostaglandin F1alpha, the urinary metabolites of thromboxane A2 and prostacyclin, were measured in diabetics by gas chromatography/selected ion monitoring. We compared the TXA2/PGI2 ratio in healthy volunteers and diabetics. The TXA2/PGI2 ratio of diabetics was significantly higher than that of healthy volunteers and we could reconfirm the hypercoagulable condition in diabetics. We also investigated the difference of TXA2/PGI2 levels in diabetics with retinopathy and neuropathy. The TXA2/PGI2 ratio of diabetics with retinopathy showed significantly higher level than without retinopathy. However, the TXA2/PGI2 ratio of diabetics with neuropathy was the same as without neuropathy. These results suggest that the TXA2/PGI2 ratio reflects the pathological conditions of diabetes, especially the change of vasculature. The monitoring and improvement of TXA2/PGI2 ratio could be useful for the prevention of diabetic vascular complications.
Hishinuma
T
T
Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan.
Tsukamoto
H
H
Suzuki
K
K
Mizugaki
M
M
D015121:6-Ketoprostaglandin F1 alpha / Q000031:analogs & derivatives* / Q000652:urine; D000328:Adult; D002849:Chromatography, Gas; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy / Q000652:urine*; D003928:Diabetic Nephropathies / Q000628:therapy / Q000652:urine*; D003929:Diabetic Neuropathies / Q000628:therapy / Q000652:urine*; D011464:Epoprostenol / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000652:urine*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C028290:2,3-dinor-6-ketoprostaglandin F1alpha; C049235:11-dehydro-thromboxane B2; D011464:Epoprostenol