title: Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues.
abstract: We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, 160 062, Punjab, India. rahuljain@mailmetoday.com
authors.forename: Rahul
authors.initials: R
authors.lastname: Jain
authors.forename: Jatinder
authors.initials: J
authors.lastname: Singh
authors.forename: Jeffery H
authors.initials: JH
authors.lastname: Perlman
authors.forename: Marvin C
authors.initials: MC
authors.lastname: Gershengorn
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D013973:Thyrotropin-Releasing Hormone