[Diagnostic significance of index alpha-amylase/glucose in amniotic fluid in prediction of fetal maturity].
An increase in alpha-amylase activity with parallel decrease in glucose concentration in amniotic fluid is observed during pregnancy. This interdependence is a theoretical basis for using an alpha-amylase/glucose index in fetal maturity evaluation. The aim of the study was to investigate usefulness of the alpha-amylase/glucose index in amniotic fluid in prenatal fetal maturity diagnosis. The study was carried out on 180 pregnant women, chosen by random selection, hospitalized in Polish Mother's Health Centre Hospital in the period from 15.06.1994 to 31.12.1995. 223 samples of amniotic fluid were tested for glucose concentration and alpha-amylase activity. It was found that the alpha-amylase/glucose < 6.0 index indicates a possibility of RDS occurring in neonates born before 72 hours of performed determination. The alpha-amylase/glucose > or = 6.0 index has high diagnostic value (95.8%) in prenatal prediction of fetal lung maturity.
Krasomski
G
G
Sałacińska
B
B
Broniarczyk
D
D
Swiatkowska
E
E
D000328:Adult; D000653:Amniotic Fluid / Q000201:enzymology / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D005260:Female; D005323:Fetal Monitoring; D005325:Fetal Organ Maturity; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis* / Q000378:metabolism; D000516:alpha-Amylases / Q000378:metabolism*
D015415:Biomarkers; D000516:alpha-Amylases; D005947:Glucose