Efficacy of pulsed intravenous immunoglobulin therapy in mixed connective tissue disease.
We describe a 69-year-old patient with long-standing mixed connective tissue disease who suffered from severe skin eruptions that did not respond to various immunosuppressive regimens. Therapy with high-dose intravenous immunoglobulin was successful in controlling the patient's disease without major side effects. We think that this regimen-although expensive-might be an interesting therapeutic option in selected patients with mixed connective tissue disease that is refractory to other treatment modalities.
Ulmer
Anja
A
University Hospital Tuebingen, Tübingen, Germany.
Kötter
Ina
I
Pfaff
Andreas
A
Fierlbeck
Gerhard
G
D000368:Aged; D005148:Facial Dermatoses / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006229:Hand Dermatoses / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D020551:Pulse Therapy, Drug; D011928:Raynaud Disease / Q000150:complications
D016756:Immunoglobulins, Intravenous