title: Rho-family GTPases in cadherin-mediated cell-cell adhesion.
abstract: Cell-cell adhesions are rearranged dynamically during tissue development and tumour metastasis. Recently, Rho-family GTPases, including RhoA, Rac1 and Cdc42, have emerged as key regulators of cadherin-mediated cell-cell adhesion. Following the identification and characterization of regulators and effectors of Rho GTPases, signal transduction pathways from cadherin to Rho GTPases and, in turn, from Rho GTPases to cadherin, are beginning to be clarified.
authors.affiliation: Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, 466-8550, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fukata
authors.forename: K
authors.initials: K
authors.lastname: Kaibuchi
mesh_terms: D000818:Animals; D015820:Cadherins / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin; D020764:cdc42 GTP-Binding Protein / Q000502:physiology; D020830:rac1 GTP-Binding Protein / Q000502:physiology; D020703:ras GTPase-Activating Proteins; D020741:rho GTP-Binding Proteins / Q000502:physiology*; D020742:rhoA GTP-Binding Protein / Q000502:physiology
chemical_list: C495273:CTNNA1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; C101203:IQ motif containing GTPase activating protein 1; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin; D020703:ras GTPase-Activating Proteins; D020764:cdc42 GTP-Binding Protein; D020830:rac1 GTP-Binding Protein; D020741:rho GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein