[Special aspects of anesthesiology and intensive care in oncological operations with microsurgical autoplasty].
The efficiency of the most rational antithrombotic, rheological, and antiischemic agents was evaluated: low-molecular heparin fraxiparin, nonsteroid antiinflammatory drug ketoprofene (ketonal), perfluorane, and antikininogen contrycal. Twenty-eight patients divided into 3 groups were examined before, during, and after extensive interventions with simultaneous microsurgical plastic repair by complex autotissue grafts. Results of treatment of 17 patients, in whom therapeutic and prophylactic complex including fraxiparin, perfluorane, and contrycal was used, deserve special attention. Use of this drug complex according to the proposed protocol creates optimal conditions for maintaining blood supply and oxygenation of the transplant at the expense of deceleration of blood clotting, decrease of blood viscosity, and decrease of erythrocyte and platelet aggregation. Complete healing of transplants was attained in all patients, who were discharged with good plastic results.
Osipova
N A
NA
Vetsheva
M S
MS
Reshetov
I V
IV
Ermolaev
P M
PM
Khovanskaia
T P
TP
Zhelezkina
N V
NV
D000328:Adult; D000758:Anesthesia / Q000379:methods*; D000925:Anticoagulants / Q000627:therapeutic use; D007611:Aprotinin / Q000008:administration & dosage / Q000627:therapeutic use; D003422:Critical Care; D004903:Erythrocyte Aggregation; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005466:Fluorocarbons / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D018056:Hemorheology; D006801:Humans; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D017762:Nadroparin / Q000008:administration & dosage / Q000627:therapeutic use; D009369:Neoplasms / Q000601:surgery*; D010974:Platelet Aggregation; D011182:Postoperative Care; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D013524:Surgical Flaps; D013997:Time Factors; D014182:Transplantation, Autologous
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D005466:Fluorocarbons; D017762:Nadroparin; D015842:Serine Proteinase Inhibitors; D007611:Aprotinin