In vitro potentiation of antibiotic activities by a catecholate iron chelator against chloroquine-resistant Plasmodium falciparum.
FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic effects in association with macrolides, ofloxacin, and rifampin.
Pradines
Bruno
B
Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, 13007 Marseille, France. bruno.pradines@free.fr
Ramiandrasoa
Florence
F
Rolain
Jean Marc
JM
Rogier
Christophe
C
Mosnier
Joel
J
Daries
William
W
Fusai
Thierry
T
Kunesch
Gerhard
G
Le Bras
Jacques
J
Parzy
Daniel
D
D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004338:Drug Combinations; D004351:Drug Resistance / Q000502:physiology; D004357:Drug Synergism; D007502:Iron Chelating Agents / Q000494:pharmacology*; D018942:Macrolides; D009643:Norfloxacin / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D013095:Spermidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000962:Antimalarials; D004338:Drug Combinations; C108048:FR 160; D007502:Iron Chelating Agents; D018942:Macrolides; D002738:Chloroquine; D013752:Tetracycline; D009643:Norfloxacin; D013095:Spermidine