Prevalence of mutagens in the environment: experimental data versus simulations.
The recent availability of experimental data on the mutagenicity in Salmonella of a subset of high production volume chemicals allowed a comparison with the estimate derived from computer-based simulations. The prevalence of mutagens in the subsets was not significantly different: 20% versus 19.5% based upon experimental and simulation data, respectively. This provides support for the use of the rapid and low-cost simulation approach.
Rosenkranz
H S
HS
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. rsnkranz@pitt.edu
Cunningham
A R
AR
D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D004785:Environmental Pollutants / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012475:Salmonella / Q000187:drug effects / Q000235:genetics
D004785:Environmental Pollutants; D009153:Mutagens