Flavonoids from Emblica officinalis and Mangifera indica-effectiveness for dyslipidemia.
Flavonoids from Emblica officinalis and Mangifera indica effectively reduce lipid levels in serum and tissues of rats induced hyperlipidemia. Hepatic HMG CoA reductase activity was significantly inhibited in rats fed E. officinalis flavonoids. But increase of this enzyme was observed in rats administered M. indica flavonoids. LCAT showed elevated levels in rats fed flavonoids from E. officinalis and M. indica. The degradation and elimination of cholesterol was highly enhanced in both the groups. In E. officinalis, the mechanism of hypolipidemic action is by the concerted action of inhibition of synthesis and enhancement of degradation. In the other group (M. indica) inhibition of cholesterogenesis was not encountered but highly significant degradation of cholesterol was noted, which may be the pivotal factor for hypolipidemic activity in this case. Though the mechanisms differ in the two cases, the net effect is to lower lipid levels.
Anila
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Department of Biochemistry, University of Kerala, Kariavattom, 695 581, Kerala, Trivandrum, India.
Vijayalakshmi
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D000818:Animals; D005419:Flavonoids / Q000302:isolation & purification / Q000627:therapeutic use*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D029842:Phyllanthus emblica; D008517:Phytotherapy; D028321:Plant Preparations; D051381:Rats; D017207:Rats, Sprague-Dawley
D005419:Flavonoids; D028321:Plant Preparations; D006903:Hydroxymethylglutaryl CoA Reductases; D008071:Lipoprotein Lipase