Facile synthesis of beta-cyclodextrin dithiols.
Nucleophilic addition of 4-methoxy-alpha-toluenethiol to capped cyclodextrins followed by deprotection in TFA affords cyclodextrin dithiols in good yields with no disulfide formation and requires only minimal purification.
Yang
Jerry
J
Department of Chemistry, Columbia University, New York, NY 10027, USA. jyang@gmwgroup.harvard.edu
Leung
David K
DK
D003505:Cyclodextrins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D014050:Toluene / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D014050:Toluene; C031215:betadex; C004848:dithiol