title: Antibacterial effect of parabens against planktonic and biofilm Streptococcus sobrinus.
abstract: Tooth decay is an infectious disease caused by bacteria immobilized on the tooth surfaces. Eradication of these bacteria, for example Streptococcus sobrinus (S. sobrinus), from the oral cavity is essential in the prevention and treatment of tooth decay. We have tested the antimicrobial effect of several paraben derivatives such as methyl (MP), ethyl (EP), propyl (PP) and butyl (BP) against immobilized and planktonic S. sobrinus. The antibacterial effect was as follows: MP>EP>PP=BP on immobilized bacteria and MP>EP=PP>BP on planktonic bacteria. An antibacterial synergistic effect was found between several combinations of parabens on immobilized and planktonic S. sobrinus. Our results indicate that parabens are potential antibacterial agents against immobilized or planktonic bacteria found in the oral cavity.
authors.affiliation: Department of Oral Biology, Faculty of Dental Medicine, Hebrew University-Hadassah, P.O. Box 12272, 91120, Jerusalem, Israel. dorons@cc.huji.ac.il
authors.forename: S
authors.initials: S
authors.lastname: Doron
authors.forename: M
authors.initials: M
authors.lastname: Friedman
authors.forename: M
authors.initials: M
authors.lastname: Falach
authors.forename: E
authors.initials: E
authors.lastname: Sadovnic
authors.forename: H
authors.initials: H
authors.lastname: Zvia
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D010226:Parabens / Q000494:pharmacology*; D013290:Streptococcal Infections / Q000382:microbiology; D016986:Streptococcus sobrinus / Q000187:drug effects* / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D010226:Parabens