title: Modular complexes that regulate actin assembly in budding yeast.
abstract: The actin cytoskeleton of budding yeast contains an extensive set of actin-associated proteins with conserved mammalian counterparts. For more than 20 years, yeast has been used as a model organism to dissect the in vivo functions of these factors, revealing an intricate web of genetic interactions in the cell. Now, a surge of biochemical reports is defining the physical interactions and activities of these proteins and providing mechanistic insights into their cellular roles. The emerging view is that most actin-associated proteins do not act alone but, rather, associate to form modular protein complexes that regulate actin assembly and organization.
authors.affiliation: Rosenstiel Medical Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA.
authors.forename: B L
authors.initials: BL
authors.lastname: Goode
authors.forename: A A
authors.initials: AA
authors.lastname: Rodal
mesh_terms: D000199:Actins / Q000737:chemistry / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D004718:Saccharomycetales / Q000502:physiology*; D013329:Structure-Activity Relationship
chemical_list: D000199:Actins