title: Cutting Edge: IL-10-producing CD4+ T cells mediate tumor rejection.
abstract: IL-10 has potent immunosuppressive properties, and IL-10-producing CD4+ Tr1 cells have been characterized as regulators of Th1-mediated immunity. In this study, using a s.c. model of glioma cell growth in mice, we demonstrate that CD4+, but not CD8+, T cells play a critical role in tumor rejection following vaccination with irradiated glioma cells. Surprisingly, glioma-specific CD4+ T cells produce IL-10 but neither IL-4 nor IFN-gamma, and glioma rejection is compromised in IL-10(-/-) hosts. Hence, our findings demonstrate that IL-10-producing CD4+ T cells can manifest antitumor functions and suggest that IL-10 may have proinflammatory effects in disease states.
authors.affiliation: Department of Neurology, The Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Benjamin_segal@urmc.rochester.edu
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Segal
authors.forename: Deborah D
authors.initials: DD
authors.lastname: Glass
authors.forename: Ethan M
authors.initials: EM
authors.lastname: Shevach
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D018572:Disease-Free Survival; D005910:Glioma / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology*; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009368:Neoplasm Transplantation; D012333:RNA, Messenger / Q000096:biosynthesis; D012074:Remission Induction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014407:Tumor Cells, Cultured; D015854:Up-Regulation
chemical_list: D016207:Cytokines; D012333:RNA, Messenger; D016753:Interleukin-10