Vancomycin-induced linear IgA disease with autoantibodies to BP180 and LAD285.
Linear IgA disease (LAD) is an acquired autoimmune subepidermal bullous disease characterized by the linear deposition of IgA at the basement membrane zone. A minority of cases are induced by drugs, of which the most frequently implicated is vancomycin. The target antigens in idiopathic LAD are heterogeneous, but have not previously been reported in vancomycin-induced LAD. We report three cases, and in two of these we investigated the target antigens. In both we identified IgA antibodies to LAD285 and IgA and IgG antibodies (dual response) to BP180.
Palmer
R A
RA
Department of Dermatology, Royal South Hants Hospital, Southampton SO14 OYG, UK. roypalmer@totlise.co.uk
Ogg
G
G
Allen
J
J
Banerjee
A
A
Ryatt
K S
KS
Ratnavel
R
R
Wojnarowska
F
F
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000139:chemically induced*; D002352:Carrier Proteins; D003094:Collagen / Q000276:immunology; D003598:Cytoskeletal Proteins; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D000071821:Dystonin; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D012867:Skin / Q000276:immunology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology; D014640:Vancomycin / Q000009:adverse effects*; D000097805:Collagen Type XVII
D000900:Anti-Bacterial Agents; D001323:Autoantibodies; D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D007070:Immunoglobulin A; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D014640:Vancomycin; D000097805:Collagen Type XVII; C486268:DST protein, human