title: Localization of hyaluronan with a hyaluronan-specific hyaluronic acid binding protein in the placenta in pre-eclampsia.
abstract: Hyaluronan (HA), a high molecular weight polysaccharide, is a major component of connective tissue and is thus present in the extracellular matrix of most tissues. Increased serum concentrations have been reported in association with pre-eclampsia and liver malfunction, amongst other disorders. We have performed histochemical investigations with a HA-specific hyaluronic acid binding protein in placentas from uncomplicated pregnancies and from patients with pre-eclampsia. Staining for HA was found in the stroma and blood vessel walls of stem villi in all the placentas investigated. The syncytiotrophoblast and cytotrophoblast cells usually remained unstained. In addition, reactivity for HA was found within and on the surface of intervillous and perivillous fibrinoid deposits. Since fibrinoid deposits are increased in pre-eclampsia, our findings suggest that the increased HA serum concentrations in cases of pre-eclampsia could result from the stroma of the infarcted villi and from the fibrinoid deposits. HA may reach the maternal blood through fibrinoid gaps.
authors.affiliation: Department of Obstetrics and Gynaecology and Julius-Maximilians-Universität, Würzburg, Germany. dragan.matejevic@mail.uni-wuerzburg.de
authors.forename: D
authors.initials: D
authors.lastname: Matejevic
authors.forename: H
authors.initials: H
authors.lastname: Neudeck
authors.forename: R
authors.initials: R
authors.lastname: Graf
authors.forename: T
authors.initials: T
authors.lastname: Müller
authors.forename: J
authors.initials: J
authors.lastname: Dietl
mesh_terms: D019921:Biotinylation; D005260:Female; D005865:Gestational Age; D006651:Histocytochemistry; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D006820:Hyaluronic Acid / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D010920:Placenta / Q000737:chemistry*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D014018:Tissue Distribution; D014327:Trophoblasts / Q000737:chemistry
chemical_list: D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid