ERKs weigh in on ribosome mass.
In this issue of Molecular Cell, Stefanovsky et al. demonstrate that the activation of the ERK1/2 MAP kinases by growth factors leads to induction of ribosomal gene transcription, through a mechanism dependent on phosphorylation of the upstream binding factor (UBF). This provides a connection between growth factor signaling and increased translation.
Gallagher
E D
ED
Department of Pharmacology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Cobb
M H
MH
D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D035463:Pol1 Transcription Initiation Complex Proteins; D011401:Promoter Regions, Genetic; D012313:RNA / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry* / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D035463:Pol1 Transcription Initiation Complex Proteins; D014157:Transcription Factors; C063844:transcription factor UBF; D012313:RNA; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases