A new locus on chromosome 19 linked with late-onset Alzheimer's disease.
Alzheimer's disease (AD) is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology. APOE 4 and APOCI A on chromosome 19 are risk factors for late-onset disease. Using large extended families with multiple siblings affected, we have identified several microsatellite markers which are also linked with late- onset Alzheimer's disease. These microsatellites are distal from the apolipoprotein cluster on chromosome 19. It is likely that multiple genes will be involved with late-onset disease, either as risk factors or as causative agents.
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Division of Neurology, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, TX 79430, USA.
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D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D001053:Apolipoproteins / Q000235:genetics*; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D009154:Mutation / Q000235:genetics*
D001053:Apolipoproteins