title: Subtle prefrontal neuropathology in a pilot magnetic resonance spectroscopy study in patients with borderline personality disorder.
abstract: The authors examined the brains of patients with borderline personality disorder (BPD) by using short echo time single voxel spectroscopy and found a significant 19% reduction of absolute N-acetylaspartate concentrations in the dorsolateral prefrontal cortex in BPD (P=0.01) compared with control subjects.
authors.affiliation: Department of Psychiatry and Psychotherapy, Albert-Ludwigs-University, Freiburg, Germany. ludger_vanelst@psyallg.ukl.uni-freiburg.de
authors.forename: L T
authors.initials: LT
authors.lastname: van Elst
authors.forename: T
authors.initials: T
authors.lastname: Thiel
authors.forename: B
authors.initials: B
authors.lastname: Hesslinger
authors.forename: K
authors.initials: K
authors.lastname: Lieb
authors.forename: M
authors.initials: M
authors.lastname: Bohus
authors.forename: J
authors.initials: J
authors.lastname: Hennig
authors.forename: D
authors.initials: D
authors.lastname: Ebert
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D001883:Borderline Personality Disorder / Q000175:diagnosis* / Q000473:pathology; D001931:Brain Mapping; D003342:Corpus Striatum / Q000473:pathology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D017397:Prefrontal Cortex / Q000473:pathology*; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D001224:Aspartic Acid; C000179:N-acetylaspartate