Growth and immunity of broiler chicks as affected by dietary arginine.
A dietary deficiency of Arg may suppress chick immune system functions; however, research evaluating immune function responsiveness of commercial broilers fed dietary Arg levels near NRC (1994) recommendations is sparse. Therefore, three experiments were conducted to evaluate growth and immunity of broilers fed varying Arg levels near NRC (1994) specifications. Because Arg and Lys are similar in structure and are known to compete in intestinal absorption, dietary Lys treatments [near NRC (1994) recommendations] were evaluated to determine if Arg and Lys interact to affect broiler immunity. There were four dietary treatments in Experiment 1 representing a 2 x 2 factorial design of additional Arg (120% of NRC) or additional Lys (120% of NRC) added to a control diet containing 100% of NRC Arg and Lys (six replications per treatment). Experiment 2 contained the following four treatments: the control diet; the control diet plus L-Arg (0.20% Arg of diet); the control diet plus L-Lys HCl (0.20% Lys of diet); and the control diet plus L-Arg-L-Glu (0.10% Arg of diet). Graduations of Arg were fed from 90 to 120% of NRC in 10% increments in Experiment 3. Also, half of the birds were exposed to vaccinations of Newcastle disease virus and infectious bronchitis virus in Experiment 3 to derive a 2 x 4 factorial design. Experiments 1 and 2 were conducted from Days 1 to 18 and Experiment 3 was conducted from Days 1 to 15 in Petersime battery brooders. No interactions occurred between dietary Lys and Arg in Experiment 1. Increasing dietary Arg, but not Lys, from 100 to 120% of the NRC recommendation increased (P < or = 0.05) Day 18 BW gain. Treatment differences in the cutaneous basophil hypersensitivity assay in Experiment 1 did not occur. In Experiment 2, treatment differences in growth responses, lymphoid organ development, and primary antibody titers to SRBC did not occur. Unvaccinated birds in Experiment 3 fed an Arg-deficient diet had lower (P < or = 0.05) feed conversion in comparison with vaccinated birds fed an Arg-deficient diet. Vaccinated birds had lower (P < or = 0.05) Day 15 BW than unvaccinated birds, but higher (P < or = 0.05) titers to Newcastle disease virus. Increasing dietary Arg in Experiment 3 increased plasma Arg (P < or = 0.05), but did not affect plasma Lys. Although increased dietary Arg improved BW gain in Experiment 1, minimal effects were noted in growth and immune system parameters throughtout this study. A dietary Arg level near the NRC (1994) recommendation should support proper immune system functions in healthy chicks.
Kidd
M T
MT
Department of Poultry Science, Mississippi State University, MS 39762, USA. mkidd@poultry.msstate.edu
Peebles
E D
ED
Whitmarsh
S K
SK
Yeatman
J B
JB
Wideman
R F
RF
D000818:Animals; D001120:Arginine / Q000008:administration & dosage*; D001491:Basophils / Q000276:immunology; D002645:Chickens / Q000254:growth & development* / Q000276:immunology*; D004032:Diet; D007109:Immunity; D001351:Infectious bronchitis virus / Q000276:immunology; D008221:Lymphoid Tissue / Q000254:growth & development; D008239:Lysine / Q000008:administration & dosage; D008297:Male; D009522:Newcastle disease virus / Q000276:immunology; D009751:Nutritional Requirements; D012882:Skin Tests / Q000662:veterinary; D014765:Viral Vaccines; D015430:Weight Gain
D014765:Viral Vaccines; D001120:Arginine; D008239:Lysine