The left-handed double helical nucleic acids.
The conversion of right-handed dsDNA and dsRNA to the left-handed Z-conformation involves a reorganization of the nucleotides relative to each other. This conversion can be facilitated by the tight binding of a Z-conformation-specific protein domain from the editing enzyme dsRNA adenosine deaminase. This may influence the modification of both pre-mRNAs as well as some replicating RNA viruses.
Brown
B A
BA
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
Rich
A
A
D000243:Adenosine Deaminase / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004278:DNA, Superhelical / Q000737:chemistry; D006801:Humans; D046911:Macromolecular Substances; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D012330:RNA, Double-Stranded / Q000737:chemistry; D016601:RNA-Binding Proteins
D004278:DNA, Superhelical; D046911:Macromolecular Substances; D012330:RNA, Double-Stranded; D016601:RNA-Binding Proteins; D012313:RNA; D004247:DNA; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase