title: The PRT protein family.
abstract: Members of the homologous PRT family are catalytic and regulatory proteins involved in nucleotide synthesis and salvage. New crystal structures have revealed key elements of PRT protein function, as well as glimpses of how the fold has evolved to perform both catalytic and regulatory functions.
authors.affiliation: Department of Biochemistry, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. sangita@chop.swmed.edu
authors.forename: S C
authors.initials: SC
authors.lastname: Sinha
authors.forename: J L
authors.initials: JL
authors.lastname: Smith
mesh_terms: D001276:ATP Phosphoribosyltransferase / Q000737:chemistry*; D020816:Amino Acid Motifs; D002384:Catalysis; D008274:Magnesium / Q000378:metabolism; D011485:Protein Binding; D017510:Protein Folding; D020836:Protein Structure, Quaternary; D012268:Ribose-Phosphate Pyrophosphokinase / Q000378:metabolism; D017385:Sequence Homology
chemical_list: D001276:ATP Phosphoribosyltransferase; D012268:Ribose-Phosphate Pyrophosphokinase; D008274:Magnesium