title: Calcification in choroidal melanoma after transpupillary thermotherapy.
abstract: OBJECTIVE
  To report the response of calcification in choroidal melanoma after transpupillary thermotherapy.
  
  
  METHODS
  Interventional case report. A 66-year-old male with a posterior uveal melanoma measuring 10 x 8 x 4.4 mm underwent infrared diode laser transpupillary thermotherapy three times, each 12 weeks apart. For each treatment, a 3-mm spot size of 1-minute duration was used, and the power setting varied between 450 mW and 500 mW.
  
  
  RESULTS
  Two months after the last transpupillary thermotherapy session, A- and B-mode echographic patterns strongly suggestive of intratumor calcification were observed. The tumor regressed to 2.8 mm in thickness, but calcification persisted. Local recurrence or distant metastasis was not detected during a follow-up of 14 months.
  
  
  CONCLUSIONS
  Clinically detectable calcification is extremely rare in choroidal melanomas. Tumor regression with slowly progressive calcification may occur after transpupillary thermotherapy.
authors.affiliation: Ocular Oncology Service, Department of Ophthalmology, Hacettepe University School of Medicine, Sihhiye TR-06100 Ankara, Turkey. Hayyamk@ttnet.net.tr
authors.forename: H
authors.initials: H
authors.lastname: Kiratli
authors.forename: S
authors.initials: S
authors.lastname: Bilgiç
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000209:etiology*; D002830:Choroid Neoplasms / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000628:therapy*; D011680:Pupil; D014463:Ultrasonography