title: Expression of GABA(A) receptor subunits in the rat central nucleus of the inferior colliculus.
abstract: Expression of GABA(A) receptor (GABA(A)R) alpha(1), alpha(2), beta(2), gamma(1), gamma(2L) and gamma(2S) subunit mRNA was examined in three cell classes in the central nucleus of the rat inferior colliculus (CNIC). GABA(A)R alpha(1) and gamma(2L) subunit mRNA expression was greatest in large cells (over 25 microm long diameter), intermediate in medium sized cells (15 to 25 microm long diameter) and lowest in small cells (10 to 15 microm long diameter). GABA(A)R gamma(2S) and alpha(2) subunits had the opposite pattern, highest in the small cells, intermediate in medium cells and lowest in large cells. GABA(A)R beta(2) was significantly lower in small cells than the two other classes, while differences between large and medium cells were not significant. GABA(A)R gamma(1) subunit mRNAs expression was not above background in any of the three cell types assessed. The expression of GABA(A)R subunits suggests that cell classes in the rat CNIC may differ in their response to GABA and GABAergic drugs.
authors.affiliation: Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USA.
authors.forename: S
authors.initials: S
authors.lastname: Shiraishi
authors.forename: Y
authors.initials: Y
authors.lastname: Shiraishi
authors.forename: D L
authors.initials: DL
authors.lastname: Oliver
authors.forename: R A
authors.initials: RA
authors.lastname: Altschuler
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000502:physiology*; D048429:Cell Size / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D017403:In Situ Hybridization; D007245:Inferior Colliculi / Q000166:cytology / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000166:cytology / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D011963:Receptors, GABA-A