Epigenetic crosstalk.
In the November 15 issue of Nature, report that disruption of histone methylation in the fungus Neurospora crassa results in the elimination of DNA methylation. This demonstrates that chromatin structure can pattern DNA methylation and suggests that different epigenetic layers engage in complex crosstalk.
Ben-Porath
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Department of Cellular Biochemistry, Hebrew University, 91120, Jerusalem, Israel.
Cedar
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D000818:Animals; D002843:Chromatin / Q000378:metabolism; D019175:DNA Methylation; D004271:DNA, Fungal / Q000378:metabolism; D004303:Dosage Compensation, Genetic; D015966:Gene Expression Regulation, Fungal; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D006657:Histones / Q000378:metabolism*; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009492:Neurospora crassa / Q000235:genetics; D011496:Protein Methyltransferases
D002843:Chromatin; D004271:DNA, Fungal; D006657:Histones; D000076983:Histone Methyltransferases; D008780:Methyltransferases; D011496:Protein Methyltransferases; D011495:Histone-Lysine N-Methyltransferase