title: Hepatic parenchymal enhancement in the cirrhotic liver: evaluation by triple-phase dynamic MRI.
abstract: BACKGROUND
  To evaluate the changes of liver parenchymal enhancement in the cirrhotic liver by means of triple-phase dynamic magnetic resonance (MR) imaging.
  
  
  METHODS
  Triple-phase multisection dynamic MR imaging was performed in 32 patients with liver cirrhosis. The control group consisted of 19 patients without liver cirrhosis. After precontrast images were obtained, arterial phase images were acquired 20 s after the start of intravenous bolus administration of 0.10 mmol/kg of gadopentetate dimeglumine. Portal and delayed phase images were then acquired 1 and 3 min, respectively, after the injection of contrast material. On each phase image, the signal-to-noise ratio (S/N) from the liver parenchyma was measured by operator-defined regions of interest (ROIs). The contrast-enhanced ratio (CER) on each phase was then obtained according to the following formula: [S/N(arterial or portal or delayed phase image) - S/N(precontrast image)] / S/N(precontrast image). The portal perfusion index (PPI) also was obtained according to the following formula: [S/N(portal phase image - S/N(arterial phase image)] / S/N(arterial phase image). The results were expressed as mean +/- SD.
  
  
  RESULTS
  The CERs of arterial, portal, and delayed phase images in patients with and without liver cirrhosis were 0.256 +/- 0.211, 0.640 +/- 0.384, and 0.554 +/- 0.318 and 0.132 +/- 0.094, 0.404 +/- 0.204, and 0.324 +/- 0.144, respectively. The CERs were highest in the portal phase and lowest in the arterial phase in patients with and without liver cirrhosis. The CER of the cirrhotic liver was significantly higher than that of the normal liver in every phase (p < 0.05). PPIs with and without liver cirrhosis were 2.90 +/- 4.03 and 3.86 +/- 3.89, respectively. The PPI with liver cirrhosis was significantly lower than that without liver cirrhosis (p < 0.05).
  
  
  CONCLUSIONS
  The enhancement of cirrhotic liver parenchyma is greater than that of the normal liver parenchyma at every phase of triple-phase dynamic MR imaging.
authors.affiliation: Department of Radiology, UBE Industries Central Hospital, 750, Nishikiwa, Ube, Yamaguchi 7550151, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Honjo
authors.forename: H
authors.initials: H
authors.lastname: Okazaki
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: N
authors.initials: N
authors.lastname: Matsunaga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008099:Liver / Q000098:blood supply / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA