Crystal structure of [Cu(N-quinolin-8-yl-p-toluenesulfonamidate)(2)]: study of its interaction with DNA and hydrogen peroxide.
A new copper complex with N-quinolin-8-yl-p-toulenesulfonamide has been prepared and characterised. The compound crystallises in the triclinic system, space group P1, with a=13.457(3), b=15.067(5), c=18.589(3) A; alpha=112.05(2), beta=93.92(2), gamma=108.30(2) degrees and Z=4. The geometry of the Cu(II) ion is distorted square planar. The N-quinolin-8-yl-p-toulenesulfonamidate anion behaves as a bidentate ligand through the N(sulfonamidate)and N(quinoline) atoms. The complex does not cleave DNA in the presence of hydrogen peroxide.
Macías
Benigno
B
Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Salamanca, Campus Unamuno, 37007 Salamanca, Spain. bmacias@gugu.usal.es
Villa
María V
MV
Fiz
Emilio
E
García
Isabel
I
Castiñeiras
Alfonso
A
Gonzalez-Alvarez
Marta
M
Borrás
Joaquín
J
D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide / Q000737:chemistry*; D006868:Hydrolysis / Q000187:drug effects; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D010957:Plasmids; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis; D013449:Sulfonamides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
C447644:Cu(N-quinolin-8-yl-p-toluenesulfonamidate)(2); D009942:Organometallic Compounds; D011804:Quinolines; D013449:Sulfonamides; D003300:Copper; D004247:DNA; D006861:Hydrogen Peroxide