Regulation of mRNA stability in the nervous system and beyond.
The ability to control gene expression is central to normal development and function. For a growing number of genes in the central nervous system and peripheral tissues, expression is determined by changes in the rate of mRNA decay. At a molecular level, regulated interactions between the mRNA target and sequence-specific binding proteins either inhibit or accelerate decay, affording tight control over gene expression. This review discusses several examples of such posttranscriptional gene regulation.
Malter
J S
JS
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA. jsmalter@facstaff.wisc.edu
D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D005809:Genes, Regulator / Q000502:physiology; D006801:Humans; D004676:Myelin Basic Protein / Q000096:biosynthesis / Q000235:genetics; D009420:Nervous System / Q000254:growth & development / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000502:physiology*; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*
D016564:Amyloid beta-Protein Precursor; D004676:Myelin Basic Protein; D012333:RNA, Messenger; D016601:RNA-Binding Proteins