title: Enlarged fetal bladders: aetiology, management and outcome.
abstract: Ultrasound routinely identifies the fetal bladder from 10 weeks of gestation. Understanding the normal embryology of the fetal bladder forms the basis of understanding the mechanisms for pathology. Early onset megacystis <12 mm (maximum diameter) frequently regresses spontaneously however when associated with other structural abnormalities 40% are chromosomally abnormal. Survival in this group is rare and the underlying histopathology is of urethral fibrostenosis. Second and third trimester megacystic indicates a heterogenous group where a precise antenatal diagnosis may be impossible. A distended thick wall bladder associated with a dilated posterior urethra and oligohydramnios is pathonemonic of posterior urethral valves; without this combination of ultrasound signs the underlying pathology is less certain. Prediction of other aetiologies for the megacystis is less accurate but includes primary reflux, cloacal plate, urethral duplication and megacystic microcolon in the differential diagnosis. Robust published data is currently unavailable to define appropriate management for individual cases of megacystis. Therefore current best practice for antenatal management will be discussed.
authors.affiliation: Department of Radiology, Birmingham Women's Hospital, Birmingham, UK.
authors.forename: J
authors.initials: J
authors.lastname: McHugo
authors.forename: M
authors.initials: M
authors.lastname: Whittle
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D005865:Gestational Age; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal; D014521:Urethra / Q000002:abnormalities / Q000000981:diagnostic imaging; D001743:Urinary Bladder / Q000002:abnormalities* / Q000000981:diagnostic imaging; D001745:Urinary Bladder Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy