title: Cyclic ADP ribose as a calcium-mobilizing messenger.
abstract: This Perspective by Galione and Churchill is one in a series on intracellular calcium release mechanisms. The authors review the evidence for cyclic adenosine diphosphate ribose (cADPR) being a second messenger involved in regulating intracellular calcium. In addition, the physiological stimuli and responses mediated by cADPR are discussed. The Perspective is accompanied by a movie showing a calcium wave triggered by cADPR.
authors.affiliation: Department of Pharmacology, University of Oxford, UK.
authors.forename: A
authors.initials: A
authors.lastname: Galione
authors.forename: G C
authors.initials: GC
authors.lastname: Churchill
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000031:analogs & derivatives* / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology; D036563:Cyclic ADP-Ribose; D006801:Humans; D015290:Second Messenger Systems / Q000502:physiology*
chemical_list: D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D002118:Calcium