title: The left-handed double helical nucleic acids.
abstract: The conversion of right-handed dsDNA and dsRNA to the left-handed Z-conformation involves a reorganization of the nucleotides relative to each other. This conversion can be facilitated by the tight binding of a Z-conformation-specific protein domain from the editing enzyme dsRNA adenosine deaminase. This may influence the modification of both pre-mRNAs as well as some replicating RNA viruses.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Rich
mesh_terms: D000243:Adenosine Deaminase / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004278:DNA, Superhelical / Q000737:chemistry; D006801:Humans; D046911:Macromolecular Substances; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D012330:RNA, Double-Stranded / Q000737:chemistry; D016601:RNA-Binding Proteins
chemical_list: D004278:DNA, Superhelical; D046911:Macromolecular Substances; D012330:RNA, Double-Stranded; D016601:RNA-Binding Proteins; D012313:RNA; D004247:DNA; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase