title: Interferon gamma gene polymorphism and susceptibility to, and severity of, rheumatoid arthritis.
abstract: A strong association between an interferon gamma (IFN-gamma) gene polymorphism and rheumatoid arthritis susceptibility and severity has been reported in a case-control study. We investigated this polymorphism in 103 patients with early rheumatoid arthritis and 130 controls. Severity of rheumatoid arthritis was measured after 4-year follow-up with a validated radiographic score. The median radiographic score in patients increased from 1 (IQR 0-4) to 11.5 (2-35) over the 4-year follow up. The distribution of IFN-gamma alleles did not differ between patients and controls, and the distribution of radiographic scores did not differ among patients carrying the different IFN-gamma alleles. We have failed to confirm the association between the IFN-gamma gene polymorphism and rheumatoid arthritis susceptibility or severity.
authors.forename: A
authors.initials: A
authors.lastname: Constantin
authors.forename: F
authors.initials: F
authors.lastname: Navaux
authors.forename: V
authors.initials: V
authors.lastname: Lauwers-Cancès
authors.forename: M
authors.initials: M
authors.lastname: Abbal
authors.forename: J P
authors.initials: JP
authors.lastname: van Meerwijk
authors.forename: B
authors.initials: B
authors.lastname: Mazières
authors.forename: A
authors.initials: A
authors.lastname: Cambon-Thomsen
authors.forename: A
authors.initials: A
authors.lastname: Cantagrel
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000145:classification / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index
chemical_list: D007371:Interferon-gamma