title: Production of prostaglandins and leukotrienes by pathogenic fungi.
abstract: These studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and systemic) have the ability to produce eicosanoids both from simple metabolites and from arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids represent a potential class of novel virulence factors.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0642, USA.
authors.forename: Mairi C
authors.initials: MC
authors.lastname: Noverr
authors.forename: Galen B
authors.initials: GB
authors.lastname: Toews
authors.forename: Gary B
authors.initials: GB
authors.lastname: Huffnagle
mesh_terms: D003545:Cysteine / Q000096:biosynthesis*; D015237:Dinoprost / Q000096:biosynthesis*; D015232:Dinoprostone / Q000096:biosynthesis*; D007975:Leukotriene B4 / Q000096:biosynthesis*; D015289:Leukotrienes / Q000096:biosynthesis*; D003904:Mitosporic Fungi / Q000254:growth & development / Q000378:metabolism*; D009090:Mucorales / Q000254:growth & development / Q000378:metabolism*; D015230:Prostaglandin D2 / Q000096:biosynthesis*
chemical_list: D015289:Leukotrienes; C112381:cysteinyl-leukotriene; D007975:Leukotriene B4; D015237:Dinoprost; D015232:Dinoprostone; D003545:Cysteine; D015230:Prostaglandin D2