Alkaloids from Cynanchum komarovii with inhibitory activity against the tobacco mosaic virus.
A pyrroloisoquinoline alkaloid, 2,3-dimethoxy-6-(3-oxo-butyl)-7,9,10,11,11a,12-hexahydrobenzo[f]pyrrolo[1,2-b]isoquinoline (1), whose structure was determined by spectroscopic methods, was isolated from the aerial parts of Cynanchum komarovii, together with two known alkaloids, 7-demethoxytylophorine (2) and 7-demethoxytylophorine N-oxide (3). Alkaloids 2 and 3 had antiviral activities against tobacco mosaic virus.
An
T
T
Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071People's Republic of China.
Huang
R Q
RQ
Yang
Z
Z
Zhang
D K
DK
Li
G R
GR
Yao
Y C
YC
Gao
J
J
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
D000470:Alkaloids; D000998:Antiviral Agents