Irresistible onset of sleep during acute levodopa challenge in a patient with multiple system atrophy (MSA): placebo-controlled, polysomnographic case report.
A 67-year-old male patient with clinically probable multiple system atrophy developed severe reproducible sleepiness and irresistible onset of sleep during an acute levodopa (L-dopa) challenge. In a placebo-controlled, double-blind study of acute L-dopa challenge, videopolysomnography revealed multiple episodes of non-rapid eye movement sleep 60 minutes after L-dopa and none following placebo. These observations suggest the irresistible sleep can also be induced by L-dopa and also in patients with atypical parkinsonism.
Högl
B
B
Universitätsklinik für Neurologie, Innsbruck Austria.
Seppi
K
K
Brandauer
E
E
Wenning
G
G
Poewe
W
W
D000368:Aged; D018592:Cross-Over Studies; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced* / Q000503:physiopathology; D015259:Dopamine Agents / Q000009:adverse effects*; D004311:Double-Blind Method; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D019578:Multiple System Atrophy / Q000175:diagnosis* / Q000503:physiopathology; D017286:Polysomnography; D012894:Sleep Stages / Q000187:drug effects*
D015259:Dopamine Agents; D007980:Levodopa