Chagasic meningoencephalitis in a patient with acquired immunodeficiency syndrome: diagnosis, follow-up, and genetic characterization of Trypanosoma cruzi.
Early diagnosis of the clinical reactivation of Chagas' disease in human immunodeficiency virus- and Trypanosoma cruzi-coinfected persons is fundamental for a good prognosis. Polymerase chain reaction rapidly and efficiently demonstrated the presence and elimination of T. cruzi in the cerebrospinal fluid of a patient with chagasic meningoencephalitis. Characterization of T. cruzi, directly and indirectly in blood and cerebrospinal fluid samples, demonstrated homogeneity of kinetoplast DNA and the presence of lineage 1 (T. cruzi II) in both parasite populations.
Lages-Silva
Eliane
E
Department of Biological Sciences, Triângulo Mineiro Faculty of Medicine, Uberaba, Minas Gerais, Brazil.
Ramirez
Luis Eduardo
LE
Silva-Vergara
Mario Leon
ML
Chiari
Egler
E
D017088:AIDS-Related Opportunistic Infections / Q000469:parasitology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000818:Animals; D020808:Central Nervous System Protozoal Infections / Q000175:diagnosis* / Q000209:etiology; D014355:Chagas Disease / Q000175:diagnosis* / Q000209:etiology; D016054:DNA, Protozoan / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014349:Trypanosoma cruzi / Q000235:genetics / Q000302:isolation & purification*
D016054:DNA, Protozoan