Genetic identification of multiple susceptibility genes involved in the development of endometrial carcinoma in a rat model.
There are clear indications that inheritance plays an essential role in certain cases of human endometrial cancer, and there are at least 2 forms of early-onset heritable endometrial adenocarcinomas (EACs). Females of the BDII inbred rat strain are known to be genetically predisposed to endometrial carcinoma, and we have performed a genetic analysis of susceptibility to endometrial cancer in this strain. F(2) populations were generated by crossing BDII females with males from 2 different strains with a low incidence of EAC, and the occurrence of endometrial cancer was studied. Three chromosome regions associated to EAC susceptibility were identified, and the susceptibility genes in these regions were designated Ecs1, Ecs2 and Ecs3. Our results indicate that the genes affecting susceptibility to EAC are different in the 2 crosses, suggesting that the genes behind the susceptibility in BDII animals may interact with different genes in different genetic backgrounds.
Roshani
L
L
CMB-Genetics, Lundberg Laboratory, Göteborg University, Göteborg, Sweden.
Wedekind
D
D
Szpirer
J
J
Taib
Z
Z
Szpirer
C
C
Beckmann
B
B
Rivière
M
M
Hedrich
H J
HJ
Klinga-Levan
K
K
D000230:Adenocarcinoma / Q000235:genetics*; D000483:Alleles; D000818:Animals; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051381:Rats