TNF cytokine family: more BAFF-ling complexities.
Recent studies on BAFF, a member of the tumor necrosis factor family, and the discovery of a new BAFF receptor have revealed that this ligand-receptor pair is essential for B-cell survival and differentiation, holding promise for a better understanding and treatment of some autoimmune diseases and lymphomas.
Laâbi
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The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, 3050, Victoria, Australia.
Egle
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Strasser
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D000818:Animals; D053264:B-Cell Activating Factor; D001402:B-Lymphocytes / Q000166:cytology; D002470:Cell Survival / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism* / Q000502:physiology
D053264:B-Cell Activating Factor; D008565:Membrane Proteins; C505720:Tnfsf13b protein, mouse; D014409:Tumor Necrosis Factor-alpha