Cytostatic activity of Achillea ageratum L.
The cytostatic activity of a chloroform extract and two isolated compounds from Achillea ageratum L. (Asteraceae) was determined in vitro against Hep-2 and McCoy cells. The chloroform extract exhibited a high degree of growth inhibition compared with the values obtained with the 6-mercaptopurine (positive control) against both cultures. Stigmasterol and beta-sitosterol, isolated from the chloroform extract, showed a high degree of growth inhibition.
Gómez
M A
MA
Laboratory of Pharmacology, Faculty of Pharmacy, University of Sevilla, 41012 Sevilla, Spain.
García
M D
MD
Sáenz
M T
MT
D000970:Antineoplastic Agents / Q000633:toxicity*; D019659:Asteraceae; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000633:toxicity*; D012855:Sitosterols / Q000633:toxicity*; D013265:Stigmasterol / Q000633:toxicity*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D010936:Plant Extracts; D012855:Sitosterols; C025473:gamma-sitosterol; D013265:Stigmasterol