Multidrug-resistant tuberculosis in prison inmates, Azerbaijan.
In a tuberculosis (TB) program in the Central Penitentiary Hospital of Azerbaijan, we analyzed 65 isolates of Mycobacterium tuberculosis by IS6110-based restriction fragment-length polymorphism (RFLP) and spoligotyping. From 11 clusters associated with 33 patients, 31 isolates had an IS6110-based banding pattern characteristic of the Beijing genotype of M. tuberculosis. In addition, 15 M. tuberculosis isolates with similar RFLP patterns constituted a single group by spoligotyping, matching the Beijing genotype. Multidrug resistance, always involving isoniazid and rifampin, was seen in 34 (52.3%) of 65 isolates, with 28 belonging to the Beijing genotype.
Pfyffer
G E
GE
University of Zurich, Switzerland. pfyffer@immv.unizh.ch
Strässle
A
A
van Gorkum
T
T
Portaels
F
F
Rigouts
L
L
Mathieu
C
C
Mirzoyev
F
F
Traore
H
H
van Embden
J D
JD
D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology; D001382:Azerbaijan / Q000453:epidemiology; D015373:Bacterial Typing Techniques; D004251:DNA Transposable Elements / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000187:drug effects / Q000235:genetics*; D009841:Oligonucleotides / Q000032:analysis; D012150:Polymorphism, Restriction Fragment Length; D011329:Prisoners; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission
D000995:Antitubercular Agents; D004251:DNA Transposable Elements; D009841:Oligonucleotides; D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit