Dynamics of NADPH diaphorase activity in raphe neurons during chronic treatment with opiates.
Systemic administration of diacetylmorphine considerably reduced the number of NADPH diaphorase-positive (NO-synthesizing) neurons in rat brain raphe nuclei. This effect was blocked by naloxone. In animals with the withdrawal syndrome NO-ergic activity in raphe neurons increased and surpassed the normal.
Dyuizen
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IV
Laboratory of Pharmacology, Institute of Sea Biology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok. iduizen@yahoo.com
Motavkin
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PA
Shorin
V V
VV
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002467:Cell Nucleus / Q000201:enzymology / Q000378:metabolism; D003932:Heroin / Q000378:metabolism / Q000494:pharmacology; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D009474:Neurons / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D011903:Raphe Nuclei / Q000201:enzymology / Q000378:metabolism*; D051381:Rats
D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D009294:Narcotics; D009569:Nitric Oxide; D009270:Naloxone; D003932:Heroin; D009252:NADPH Dehydrogenase