Comparison of plasma alpha glutathione S-transferase concentrations during and after low-flow sevoflurane or isoflurane anaesthesia.
BACKGROUND
We evaluated the effect of low-flow sevoflurane anaesthesia, in which compound A is generated, and isoflurane anaesthesia, in which compound A is not generated (n=13 in each group), on hepatocellular integrity using alpha glutathione S-transferase (GST). Alpha GST is a more sensitive and specific marker of hepatocellular damage than is aminotransferase activity and correlates better with hepatic histology.


METHODS
Sevoflurane or isoflurane were delivered without nitrous oxide with a fresh gas flow of 1 l/min. Concentrations of compound A in the circuit were measured hourly, and plasma alpha GST concentrations were measured perioperatively.


RESULTS
Mean duration of anaesthesia was 338+/-92 min in the sevoflurane group and 320+/-63 min in the isoflurane group. Mean compound A concentration in the sevoflurane group was 28.6+/-9.0 ppm. There was no significant difference in alpha GST concentrations between the sevoflurane and isoflurane groups during or after anaesthesia.


CONCLUSIONS
These results indicate that low-flow sevoflurane and isoflurane anaesthesia have the same effect on hepatic function, as assessed by plasma alpha GST concentrations.
Higuchi
H
H
Department of Anaesthesia, Self Defense Force Central Hospital, Setagaya, Tokyo, Japan. higu-chi@ka2.so-net.ne.jp
Adachi
Y
Y
Wada
H
H
Kanno
M
M
Satoh
T
T
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000769:Anesthesia, Inhalation / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D004987:Ethers / Q000009:adverse effects / Q000032:analysis; D005982:Glutathione Transferase / Q000097:blood*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000009:adverse effects / Q000032:analysis; D007527:Isoenzymes / Q000097:blood*; D007530:Isoflurane / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D015415:Biomarkers; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D007527:Isoenzymes; D008738:Methyl Ethers; D000077149:Sevoflurane; C078742:fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether; D007530:Isoflurane; D005982:Glutathione Transferase; C119995:glutathione S-transferase alpha; D000410:Alanine Transaminase