title: Early bronchopulmonary involvement in Crohn disease: a case report.
abstract: BACKGROUND
  Bronchopulmonary manifestations of Crohn disease have been rarely described in children, including both subclinical pulmonary involvement and severe lung disease.
  
  
  METHODS
  A 6.5-year-old girl is described with early recurrent bronchopulmonary symptoms both at presentation and in the quiescent phase of Crohn disease. Pulmonary function tests (lung volumes and flows, bronchial reactivity and carbon monoxide diffusing capacity) were normal. Bronchoalveolar cytology showed increased (30%) lymphocyte counts and bronchial biopsy revealed thickening of basal membrane and active chronic inflammation.
  
  
  CONCLUSIONS
  Clinical and histological findings in our young patient suggest involvement of both distal and central airways in an early phase of lung disease. The pathogenesis of Crohn disease-associated lung disorders is discussed with reference to the available literature. A low threshold for pulmonary evaluation seems to be advisable in all children with CD.
authors.affiliation: Department of Pediatrics, University of Verona, Italy. hwwval@tin.it
authors.forename: E
authors.initials: E
authors.lastname: Valletta
authors.forename: M
authors.initials: M
authors.lastname: Bertini
authors.forename: L
authors.initials: L
authors.lastname: Sette
authors.forename: C
authors.initials: C
authors.lastname: Braggion
authors.forename: U
authors.initials: U
authors.lastname: Pradal
authors.forename: M
authors.initials: M
authors.lastname: Zannoni
mesh_terms: D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D001996:Bronchopneumonia / Q000000981:diagnostic imaging / Q000209:etiology*; D002648:Child; D003106:Colon / Q000473:pathology; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D011859:Radiography