title: IGFBP-1 and glycodelin serum levels before and after hysterectomy with and without bilateral oophorectomy in premenopausal women.
abstract: OBJECTIVE
  The aim of our study was to investigate the role of the intact endometrium and ovaries for serum levels of insulin-like growth factor binding protein-1 (IGFBP-1) and glycodelin.
  
  
  METHODS
  In 35 premenopausal patients with a planned hysterectomy, serum measurements of IGFBP-1 and glycodelin were done before surgery and 1, 3, 5, and 10 days after surgery. Patients were divided into three groups according to the kind and time of operation: (1) hysterectomy with bilateral adnexectomy in the luteal phase and (2) hysterectomy without adnexectomy in the follicular phase or (3) the luteal phase.
  
  
  RESULTS
  IGFBP-1-we could not show any differences in IGFBP-1 serum levels before and after hysterectomy with or without bilateral oophorectomy. Glycodelin-hysterectomized and oophorectomized patients showed decreasing serum levels up to day 3. After day 5, circulating concentrations of glycodelin increased continuously but remained below pre-operative levels. In both non-adnexectomized groups we saw a reduction up to day 5 but a rise at day 10. None of the results reached statistical significance.
  
  
  CONCLUSIONS
  The results indicate that endometrium and ovary are not the only sources of IGFBP-1 and glycodelin.
authors.affiliation: Department of Obstetrics and Gynecology, University of Cologne, Kerpener Str. 34, 50931 Köln, Germany. dfoth@t-online.de
authors.forename: D
authors.initials: D
authors.lastname: Foth
authors.forename: M
authors.initials: M
authors.lastname: Meisel
authors.forename: F
authors.initials: F
authors.lastname: Nawroth
authors.forename: W
authors.initials: W
authors.lastname: Straube
authors.forename: T
authors.initials: T
authors.lastname: Römer
mesh_terms: D000328:Adult; D005260:Female; D005498:Follicular Phase; D000071816:Glycodelin; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007044:Hysterectomy; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D008183:Luteal Phase; D008875:Middle Aged; D010052:Ovariectomy; D011257:Pregnancy Proteins / Q000097:blood*; D017697:Premenopause
chemical_list: D000071816:Glycodelin; D006023:Glycoproteins; D018970:Insulin-Like Growth Factor Binding Protein 1; C045246:PAEP protein, human; D011257:Pregnancy Proteins