Somatostatin type V receptor activates c-Jun N-terminal kinases via Galpha(12) family G proteins.
Somatostatin is a neurotransmitter with diverse effects including anti-proliferation in a wide range of normal and neoplastic cells, and occasionally growth stimulatory and neurotrophic actions. Stress-activated protein kinase or c-Jun N-terminal kinase (SAPK/JNK) can also induce growth arrest and occasionally growth stimulation. However, the relationship between somatostatin and SAPK/JNK is less clear. Here we report that the binding of somatostatin to the somatostatin receptor type V (SSTR5) upregulates SAPK/JNK activity. We also show that this activation is mediated by Galpha(12) and Galpha(13). This study demonstrates that SSTR5 is the heptahelical receptor that activates SAPK/JNK via the G(12) family G proteins.
Komatsuzaki
K
K
Department of Pediatrics, Pediatric Pulmonary Service, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA.
Terashita
K
K
Kinane
T B
TB
Nishimoto
I
I
D000818:Animals; D019556:COS Cells; D004789:Enzyme Activation / Q000187:drug effects; D044365:GTP-Binding Protein alpha Subunits, G12-G13; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases; D007700:Kinetics; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D017481:Receptors, Somatostatin / Q000235:genetics / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism / Q000494:pharmacology; D014162:Transfection
D017481:Receptors, Somatostatin; D013004:Somatostatin; C094573:somatostatin receptor 5; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases; D044365:GTP-Binding Protein alpha Subunits, G12-G13; D020962:Heterotrimeric GTP-Binding Proteins