title: Epstein-Barr virus dacryoadenitis resulting in keratoconjunctivitis sicca in a child.
abstract: OBJECTIVE
  To describe a case of severe dry eye syndrome in a child.
  
  
  METHODS
  Observational case report. The authors describe a 10-year-old male with severe dry eyes who was profoundly disabled by pain and photophobia despite aggressive conventional therapy. Lacrimal gland histology was consistent with the primary Sjögren syndrome, and serologic and immunohistologic evidence supported the hypothesis of Epstein-Barr virus causality.
  
  
  RESULTS
  Treatment with systemic acyclovir and cyclosporin A resulted in dramatic and rapid reversal of the profound sicca syndrome and enabled the patient to resume his normal activities.
  
  
  CONCLUSIONS
  Epstein-Barr virus dacryoadenitis should be considered in the differential diagnosis of keratoconjunctivitis sicca in children. Epstein-Barr virus can cause keratoconjunctivitis sicca, which can be treated successfully with acyclovir therapy in addition to suppression of the inflammatory response.
authors.affiliation: Ocular Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
authors.forename: J
authors.initials: J
authors.lastname: Merayo-Lloves
authors.forename: S
authors.initials: S
authors.lastname: Baltatzis
authors.forename: C S
authors.initials: CS
authors.lastname: Foster
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use; D003607:Dacryocystitis / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D004359:Drug Therapy, Combination; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007638:Keratoconjunctivitis Sicca / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008297:Male; D009301:Nasolacrimal Duct / Q000821:virology; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011241:Prednisone; D000212:Acyclovir