title: Effects of cerebellar dentate nucleus GABAergic cells on rat inferior olivary neurons.
abstract: The present study was undertaken to analyze the effects on unitary activity of inferior olive (IO) neurons elicited by activation of cerebellar lateral nucleus (LN), in rats submitted to the chronic destruction of MDJ structures, i.e. in animals in which the LN-evoked effects in IO should be depended only on activation of GABAergic cells of LN. It has been observed that about two-thirds of the olivocerebellar neurons are significantly affected by LN stimulation, and > 68% of those cells were inhibited. Two-thirds of the inhibitory responses were compatible with a monosynaptic linkage, whereas the remaining inhibitions were probably due to polisynaptic linkages. The majority of LN-induced inhibitions was abolished or greatly reduced following application of GABA antagonists.
authors.affiliation: Department of Physiological Sciences, University of Catania, viale Andrea Doria 6, 95125 Catania, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Garifoli
authors.forename: G
authors.initials: G
authors.lastname: Scardilli
authors.forename: V
authors.initials: V
authors.lastname: Perciavalle
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002529:Cerebellar Nuclei / Q000166:cytology / Q000378:metabolism*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D007839:Functional Laterality / Q000502:physiology; D018756:GABA Antagonists / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009434:Neural Pathways / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009847:Olivary Nucleus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D018690:Excitatory Amino Acid Agonists; D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid; D007608:Kainic Acid