Cardioactive diterpenoids from the roots of Salvia amplexicaulis.
Five diterpenoids, three steroids, four triterpenoids and one flavonoid were isolated from the roots of Salvia amplexicaulis Lam. (Lamiaceae). Structures of these compounds were elucidated by spectroscopic analysis. The crude extract and the pure compounds were tested for cardiovascular parameters using Wistar Albino rats. The crude extract, and 7-oxo-abieta-9,12,14-triene, ferruginol, stigmast-4-en-3-one showed a vasodepressor effect.
Kolak
U
U
University of Istanbul, Faculty of Pharmacy, Department of Chemistry, Istanbul, Turkey.
Ari
S
S
Birman
H
H
Hasançebi
S
S
Ulubelen
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D027544:Salvia / Q000737:chemistry*; D014662:Vasoconstrictor Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*
D004224:Diterpenes; D028321:Plant Preparations; D014662:Vasoconstrictor Agents