Pharmacokinetics and inflammatory fluid penetration of intravenous daptomycin in volunteers.
The lipopeptide antimicrobial daptomycin was administered intravenously at a dose of 4 mg/kg of body weight to seven healthy male volunteers. The concentrations of daptomycin in plasma, cantharidin-induced inflammatory fluid, and urine were measured by a microbiological assay. The mean +/- standard deviation peak concentrations in plasma and inflammatory fluid were 77.5 +/- 8.3 and 27.6 +/- 9.5 microg/ml, respectively; the mean terminal elimination half-lives were 7.74 and 13.2 h, respectively. The overall penetration of total drug into the inflammatory fluid (measured by ratio of the area under the concentration-time curve from 0 to 24 h for inflammatory fluid compared with that for plasma) was 68.4%. The mean urinary recovery over 24 h was 59.7%.
Wise
R
R
Department of Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom. r.wise@bham.ac.uk
Gee
T
T
Andrews
J M
JM
Dvorchik
B
B
Marshall
G
G
D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D001826:Body Fluids / Q000378:metabolism; D002193:Cantharidin; D017576:Daptomycin / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D007262:Infusions, Intravenous; D008297:Male
D000900:Anti-Bacterial Agents; D002193:Cantharidin; D017576:Daptomycin