title: Early EUS of the bile duct before endoscopic sphincterotomy for acute biliary pancreatitis.
abstract: BACKGROUND
  Endoscopic sphincterotomy can benefit patients with suspected biliary pancreatitis, although there are procedure-related complications. EUS can be used to select patients for endoscopic sphincterotomy. The results of this strategy were assessed.
  
  
  METHODS
  Information on patients referred for EUS were recorded in a database. One hundred twenty-three patients with suspected biliary pancreatitis (57 men, 66 women; median age 55 years) were included and followed. All underwent EUS followed by endoscopic sphincterotomy during the same procedure if choledocholithiasis was identified. Outcomes were studied in relation to the initial severity of biliary pancreatitis (Ranson and Balthazar scores), presence of stones, and time span between onset of biliary pancreatitis and EUS plus endoscopic sphincterotomy.
  
  
  RESULTS
  Thirty-five patients (28%) had a Ranson score greater than 3 on admission and 38 (31%) were Balthazar D-E. The median time from admission to EUS was 3 days. EUS imaging of the bile duct was complete in all but 3 patients. Thirty-three patients (27%) had choledocholithiasis on EUS and underwent endoscopic sphincterotomy. Stones were more frequent in patients with jaundice (p < 0.005) and when EUS was performed less than 3 days after admission (p < 0.05). One hundred patients (81%) recovered without complication. Two patients (1.6%) died, 1 had recurrent BP develop, 6 (5%) had further biliary symptoms, and 16 (13%) had complications of pancreatitis develop (9 pseudocysts). There were 3 mild endoscopic sphincterotomy-related complications (complication rate 6.5%).
  
  
  CONCLUSIONS
  In this series in which endoscopic sphincterotomy was performed selectively depending on the endosonographic presence or absence of ductal stones early in the course of the pancreatitis, and not according to its predicted severity, mortality and complications of endoscopic sphincterotomy were low and unrelated to the predicted severity of biliary pancreatitis or the presence of choledocholithiasis. Controlled trials are needed to confirm the superiority of this strategy compared with ERCP alone for the management of biliary pancreatitis.
authors.affiliation: Bachaumont Hepato-Biliary Center, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Prat
authors.forename: J
authors.initials: J
authors.lastname: Edery
authors.forename: B
authors.initials: B
authors.lastname: Meduri
authors.forename: R
authors.initials: R
authors.lastname: Chiche
authors.forename: C
authors.initials: C
authors.lastname: Ayoun
authors.forename: M
authors.initials: M
authors.lastname: Bodart
authors.forename: D
authors.initials: D
authors.lastname: Grange
authors.forename: F
authors.initials: F
authors.lastname: Loison
authors.forename: P
authors.initials: P
authors.lastname: Nedelec
authors.forename: M S
authors.initials: MS
authors.lastname: Sbai-Idrissi
authors.forename: A
authors.initials: A
authors.lastname: Valverde
authors.forename: B
authors.initials: B
authors.lastname: Vergeau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods; D019160:Endosonography; D005260:Female; D005500:Follow-Up Studies; D042882:Gallstones / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016717:Sphincterotomy, Endoscopic / Q000379:methods; D015996:Survival Rate