title: Resistance to amphotericin B does not emerge during treatment for invasive aspergillosis.
abstract: Emergence of resistance to antifungal drugs during therapy for invasive aspergillosis has received scant attention. We recovered Aspergillus isolates from six patients with invasive aspergillosis, who were receiving amphotericin B before fungal isolation. Although isolates were susceptible to amphotericin B in vitro, none of the patients survived. The MIC of amphotericin B for isolates was similar to that for isolates from 35 patients with no prior exposure to amphotericin B. Laboratory attempts to produce amphotericin B resistance in Aspergillus were unsuccessful. These data indicate that emergence of resistance to amphotericin B is uncommon during therapy for invasive aspergillosis.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA.
authors.forename: Mahomed-Yunus S
authors.initials: MY
authors.lastname: Moosa
authors.forename: George J
authors.initials: GJ
authors.lastname: Alangaden
authors.forename: Elias
authors.initials: E
authors.lastname: Manavathu
authors.forename: Pranatharthi H
authors.initials: PH
authors.lastname: Chandrasekar
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000302:isolation & purification; D001234:Aspergillus niger / Q000187:drug effects / Q000302:isolation & purification; D025141:Drug Resistance, Fungal / Q000502:physiology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B