title: A mixed modality paradigm for recording somatosensory and auditory P50 gating.
abstract: Significant somatosensory evoked potential (SEP) P50 gating has previously been found in young healthy men by the use of identical paired stimuli. In this study, the exploration of the gating paradigm was extended with the addition of a mixed modality paradigm where three different pairs of identical stimuli (clicks, right median nerve electric stimulations and proprioceptive stimuli of changing load on a handheld weight) were presented over a 12-s cycle. In both modalities repeated measures analyses of variance demonstrated no effect of paradigm. This mixed-modality recording paradigm could be used in further experiments to examine gating deficits across modalities.
authors.affiliation: Department of Psychiatry, University Hospital of Copenhagen, Bispebjerg, Bispebjerg Bakke 23, DK-2400 NV, København, Denmark. sidse.arnfred@dadlnet.dk
authors.forename: S M
authors.initials: SM
authors.lastname: Arnfred
authors.forename: A C
authors.initials: AC
authors.lastname: Chen
authors.forename: D N
authors.initials: DN
authors.lastname: Eder
authors.forename: B Y
authors.initials: BY
authors.lastname: Glenthøj
authors.forename: R P
authors.initials: RP
authors.lastname: Hemmingsen
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology*; D011434:Proprioception / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values; D016474:Weight-Bearing / Q000502:physiology