Effect of angiotensin-converting enzyme inhibitor on renal function in ovarian hyperstimulation syndrome in the rabbit.
OBJECTIVE
To investigate renal function and whether captopril prevents alterations in the handling of sodium and water in the ovarian hyperstimulation syndrome (OHSS) in the rabbit.


METHODS
Experimental study


METHODS
Physiology laboratory.


METHODS
Six female New Zealand white rabbits were used as controls, and 13 were hyperstimulated with gonadotropins.


METHODS
Saline or captopril.


METHODS
Renal excretory and hemodynamic variables.


RESULTS
The 3% extracellular volume expansion in OHSS animals induced a significant elevation in mean arterial pressure by 27%, although increments in natriuresis and diuresis were similar to those observed in controls. The OHSS group had impaired pressure-natriuresis sensitivity compared with controls (0.36 +/- 0.07 microEq/min/g of Na excreted per mm Hg vs. 1.74 +/- 0.45 microEq/min/g of Na excreted per mm Hg; P<.05. Captopril significantly reduced mean arterial pressure (P<.05) and shifted the pressure-natriuresis response to the left by 0.85 +/- 0.17 microEq/min/g of Na excreted per mm Hg (P<.05).


CONCLUSIONS
In OHSS in the rabbit model, pressure-natriuresis sensitivity is impaired. Angiotensin II may play a significant role in this phenomenon, since angiotensin-converting enzyme inhibition normalized the pressure-natriuresis relationship.
Teruel
M J
MJ
Departmento de Fisiología de la Universidad de Murcia, Murcia, Spain.
Carbonell
L F
LF
Teruel
M G
MG
Parrilla
J J
JJ
Abad
L
L
Hernandez
I
I
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D007444:Inulin / Q000097:blood / Q000652:urine; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology*; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology / Q000503:physiopathology*; D011817:Rabbits; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D012964:Sodium / Q000097:blood / Q000652:urine; D010130:p-Aminohippuric Acid / Q000097:blood / Q000652:urine
D000806:Angiotensin-Converting Enzyme Inhibitors; D007444:Inulin; D002216:Captopril; D012964:Sodium; D010130:p-Aminohippuric Acid