Phenytoin hypersensitivity syndrome.
Phenytoin hypersensitivity syndrome (PHS) is a rare, and important entity characterized by rash, fever, lymphadenopathy, leukocytosis with atypical lymphocytes, eosinophilia and associated hepatitis. In this article, we present the clinical, laboratory and histopathologic results of 5 cases of PHS. In therapy, pheyntoin was stopped and sodium valproate (10-20 mg/kg day) was started. Additionally, prednisolone was given in two patients who had not resolved eruption with conservative therapy.
Güngör
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E
Department of Dermatology, Ankara Numune Hospital, Ankara, Turkey.
Alli
N
N
Comoğlu
S
S
Cömcüoğlu
C
C
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000150:complications / Q000473:pathology*; D004802:Eosinophilia / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D005260:Female; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*
D000927:Anticonvulsants; D010672:Phenytoin