title: Why is DNA damage signaling so complicated? Chaos and molecular signaling.
abstract: Molecular signaling in eukaryotic cells is accomplished by complex and redundant pathways converging on key molecules that are allosterically controlled by a limited number of signaling proteins. The p53-signaling pathway is an example of a complicated sequence of signals produced in response to DNA damage. This pattern of signaling may arise from chance occurrences at the origin of life and the necessities imposed on a nanomolar system. From this viewpoint, chaos theory may explain the origin, complexity, and convergence of these pathways.
authors.affiliation: AGI Dermatics, Freeport, New York 11520, USA. danyarosh@agiderm.com
authors.forename: D B
authors.initials: DB
authors.lastname: Yarosh
mesh_terms: D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D016158:Genes, p53; D006801:Humans; D017711:Nonlinear Dynamics; D015398:Signal Transduction