Mycobacterium tuberculosis Beijing genotype strains associated with febrile response to treatment.
DNA fingerprinting has demonstrated predominance of the Beijing genotype among Mycobacterium tuberculosis strains isolated in Southeast Asia. We prospectively examined the occurrence of Beijing genotype strains in tuberculosis patients in Indonesia. Early in treatment, patients infected with Beijing genotype strains more often had fever unrelated to disease severity, toxicity, or drug resistance, indicating that Beijing genotype strains may have specific pathogenic properties.
van Crevel
R
R
University Medical Center Nijmegen, The Netherlands. r.vancrevel@aig.azn.nl
Nelwan
R H
RH
de Lenne
W
W
Veeraragu
Y
Y
van der Zanden
A G
AG
Amin
Z
Z
van der Meer
J W
JW
van Soolingen
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002681:China; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial; D005260:Female; D005334:Fever; D005838:Genotype; D006801:Humans; D007214:Indonesia; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D012150:Polymorphism, Restriction Fragment Length; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology*
D000995:Antitubercular Agents; D004251:DNA Transposable Elements