title: Motor perseveration is an early sign of Parkinson's disease.
abstract: Perseveration in the generation of random motor behavior was examined by means of the Vienna perseverance task in groups of de novo (n = 18) and treated (n = 18) patients with early PD, and in control subjects (n = 18). In comparison with control subjects, both the de novo and treated patients with PD were relatively unable to generate random motor sequences, indicating a decreased ability to switch cortical behavioral programs in PD. An impairment of random motor generation appears to be a very early feature of PD.
authors.affiliation: Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. d.stoffers@vumc.nl
authors.forename: D
authors.initials: D
authors.lastname: Stoffers
authors.forename: H W
authors.initials: HW
authors.lastname: Berendse
authors.forename: J B
authors.initials: JB
authors.lastname: Deijen
authors.forename: E C
authors.initials: EC
authors.lastname: Wolters
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012691:Serial Learning / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D000978:Antiparkinson Agents