title: Oxidized heptenes from flowers of Melodorum fruticosum.
abstract: Three oxidized heptenes, 7-benzoyloxy-6-oxo-2,4Z-heptadiene-1,4-olide, [7-benzoyloxy-4-hydroxy-1-methoxy-2E,4Z-heptadiene-1,6-dione] and 7-benzoyloxy-6-oxo-2,4E-heptadiene-1,4-olide, were isolated from flowers of Melodorum fruticosum. Their structures were determined by spectral data analysis. The first two compounds exhibited moderate cytotoxicity against a panel of human tumor cell lines, whereas the third was inactive.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. chaiyo@chula.ac.th
authors.forename: C
authors.initials: C
authors.lastname: Chaichantipyuth
authors.forename: S
authors.initials: S
authors.lastname: Tiyaworanan
authors.forename: S
authors.initials: S
authors.lastname: Mekaroonreung
authors.forename: N
authors.initials: N
authors.lastname: Ngamrojnavanich
authors.forename: S
authors.initials: S
authors.lastname: Roengsumran
authors.forename: S
authors.initials: S
authors.lastname: Puthong
authors.forename: A
authors.initials: A
authors.lastname: Petsom
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000475:Alkenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010084:Oxidation-Reduction
chemical_list: C447027:7-benzoyloxy-4-hydroxy-1-methoxy-2,4-heptadiene-1,6-dione; C447026:7-benzoyloxy-6-oxo-2,4-heptadiene-1,4-olide; D000475:Alkenes; D000972:Antineoplastic Agents, Phytogenic