The use of osteogenic protein-1 in reconstructive surgery of the hip.
Osteogenic proteins (OPs), also referred to as bone morphogenetic proteins (BMPs), are a family of bone matrix polypeptides that induce a sequence of cellular events that lead to the formation of new bone. This article reports the use of recombinant human OP-1 (rhOP-1, rhBMP-7) in preclinical animal models and initial human clinical experience in hip reconstructive surgery. The use of rhOP-1 in conjunction with morcellized cancellous bone and cortical strut allograft in preclinical models dramatically improved the biologic activity of the graft, resulting in greater and earlier new bone formation and graft incorporation. The clinical use of rhOP-1 in hip reconstructive procedures also resulted in greater and earlier new bone formation in the more challenging biologic environment compared with allograft bone alone.
Cook
S D
SD
Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA. scook2@tulane.edu
Barrack
R L
RL
Shimmin
A
A
Morgan
D
D
Carvajal
J P
JP
D000818:Animals; D019644:Arthroplasty, Replacement, Hip; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D016025:Bone Transplantation; D004285:Dogs; D006801:Humans; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D019736:Prostheses and Implants; D011994:Recombinant Proteins / Q000494:pharmacology*; D016212:Transforming Growth Factor beta; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta