Collecting duct renal cell carcinoma: clinical study of a rare tumor.
OBJECTIVE
Collecting duct carcinoma is a rare type of renal cell carcinoma that affects younger patients, and is associated with aggressive regional and distant spread. The clinical and pathological features of 6 patients with collecting duct carcinoma treated at a single institution are described.


METHODS
There were 6 patients with collecting duct carcinoma included in the University of California School of Medicine, Los Angeles, Kidney Cancer Database. Demographic, clinical, pathological and survival data were gathered.


RESULTS
Average patient age plus or minus standard deviation was 56 +/- 11 years, and 5 of 6 had TNM stage IV disease. The average survival of these patients was 11.5 months (range 7 to 17). There was 1 patient who had TNM stage I disease and survived without evidence of disease at 5 years. Transient response to chemotherapy was seen in 1 patient.


CONCLUSIONS
Collecting duct carcinoma is associated with poor prognosis. For the majority of patients surgical treatment will not result in a cure. Previously recommended chemotherapy and/or immunotherapy appears to have a limited role in treatment of this disease, and early detection may be the best method for prolonging patient survival.
Chao
Debby
D
Department of Urology, Division of Urologic Oncology, University of California School of Medicine-Los Angeles, Los Angeles, CA, USA.
Zisman
Amnon
A
Pantuck
Allan J
AJ
Gitlitz
Barbara J
BJ
Freedland
Stephen J
SJ
Said
Jonathan W
JW
Figlin
Robert A
RA
Belldegrun
Arie S
AS
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D007685:Kidney Tubules, Collecting; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis