Impairment of mitogenic activation of peripheral blood lymphocytes in Alzheimer's disease.
Cell-cycle dysregulation might be critically involved in the process of neurodegeneration in Alzheimer's disease (AD). We now provide evidence for a dysfunction of the cell division cycle as a more general cellular phenomenon of the disease. Peripheral blood lymphocytes, stimulated with mitogenic compounds, were less able to express CD69, an early proliferation marker, in AD patients than in age-matched controls. Expression levels of CD69 of both T-cells and B-cells correlated inversely with the Mini-mental Scale. The results suggest that a systemic failure of cellular proliferation control might be of critical importance for the pathomechanism of AD.
Stieler
J T
JT
Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany.
Lederer
C
C
Brückner
M K
MK
Wolf
H
H
Holzer
M
M
Gertz
H J
HJ
Arendt
T
T
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D015703:Antigens, CD / Q000096:biosynthesis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000096:biosynthesis; D001057:Apolipoproteins E / Q000235:genetics; D001402:B-Lymphocytes / Q000166:cytology* / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D005434:Flow Cytometry; D005838:Genotype; D006801:Humans; D037181:Lectins, C-Type; D008934:Mitogens / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D001057:Apolipoproteins E; D037181:Lectins, C-Type; D008934:Mitogens; D000099192:CD69 Antigens