title: Pibocin B, the first N-O-methylindole marine alkaloid, a metabolite from the Far-Eastern ascidian Eudistoma species.
abstract: Pibocin B (2), the first representative of marine alkaloids with a unique structural feature, an N-O-methylindole group, was isolated from the Far-Eastern ascidian Eudistoma sp. Its structure has been established as (8 beta)-2-bromo-N-O-methyl-6,8-dimethylergoline on the basis of NMR data, FAB and MALDI-TOF MS, and chemical correlations. Pibocin B showed moderate cytotoxic activity against mouse Ehrlich carcinoma cells.
authors.affiliation: Laboratory of Marine Natural Products, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 690022 Vladivostok, Russian Federation. piboc@stl.ru
authors.forename: T N
authors.initials: TN
authors.lastname: Makarieva
authors.forename: A S
authors.initials: AS
authors.lastname: Dmitrenok
authors.forename: P S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: B B
authors.initials: BB
authors.lastname: Grebnev
authors.forename: V A
authors.initials: VA
authors.lastname: Stonik
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor; D018360:Crystallography, X-Ray; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012426:Russia; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013211:Staphylococcus aureus / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C446692:pibocin A; C446691:pibocin B