TGF-beta flips the Myc switch.
Although transforming growth factor-beta (TGF-beta) can affect cell cycle arrest, not much molecular detail is known about how TGF-beta-dependent arrest is mediated. Two recent papers shed some light on how this is accomplished. Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15(INK4b), and how TGF-beta is able to unblock Myc-dependent repression of Miz-1.
Orian
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Division of Basic Sciences, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA. eisenman@fhcrc.org
Eisenman
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D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D016259:Genes, myc / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta