title: A mercapto analogue of 5'-noraristeromycin.
abstract: 5'-Noraristeromycin and its enantiomer have been found to possess a wide range of antiviral effects. In the search for analogues of and with improved activity, the synthesis of both enantiomers of 5'-mercapto-5'-deoxy-5'-noraristeromycin ( and ) has been accomplished. While (+)-7 was inactive, (-)- did show marginal activity against vaccinia virus, but not any other virus.
authors.affiliation: Department of Chemistry, Auburn University, Auburn, AL 36849-5312, USA.
authors.forename: Subha R
authors.initials: SR
authors.lastname: Das
authors.forename: Stewart W
authors.initials: SW
authors.lastname: Schneller
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D004353:Drug Evaluation, Preclinical / Q000379:methods; D013329:Structure-Activity Relationship; D014616:Vaccinia virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; C076829:5'-noraristeromycin; D000241:Adenosine