5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium.
5-Demethylovalicin was isolated from the fermentation broth Chrysosporium lucknowense and the structure was identified by spectroscopic methods. 5-Demethylovalicin inhibited the recombinant human MetAP-2 (IC(50)=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC(50)=100 nM) in cell proliferation assay without cytotoxicity on the transformed and cancer cell lines.
Son
Kwang-Hee
KH
Korea Research Institute of Bioscience and Biotechnology, 52-Eundong, Yusong, 305-333, Taejon, Republic of Korea. sonkh@mail.kribb.re.kr
Kwon
Ju-Young
JY
Jeong
Ha-Won
HW
Kim
Hyae-Kyeong
HK
Kim
Chang-Jin
CJ
Chang
Yie-Hwa
YH
Choi
Jung-Do
JD
Kwon
Byoung-Mog
BM
D000626:Aminopeptidases / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D002912:Chrysosporium / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D012717:Sesquiterpenes / Q000494:pharmacology*
C448859:5-demethylovalicin; D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; D012717:Sesquiterpenes; D000626:Aminopeptidases; C106541:methionine aminopeptidase 2; D008666:Metalloendopeptidases