title: STK receptor tyrosine kinase regulates susceptibility to infection with Listeria monocytogenes.
abstract: We have previously identified the STK receptor tyrosine kinase as a key regulator of macrophage activation and cell-mediated immune responses. Here we demonstrate that, although MSP activation of STK inhibits NO production by macrophages in response to heat-killed Listeria monocytogenes, STK-deficient mice exhibit increased susceptibility to infection with Listeria.
authors.affiliation: Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802-3500, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Lutz
authors.forename: Francine
authors.initials: F
authors.lastname: Gervais
authors.forename: Alan
authors.initials: A
authors.lastname: Bernstein
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Hattel
authors.forename: Pamela H
authors.initials: PH
authors.lastname: Correll
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004198:Disease Susceptibility; D006133:Growth Substances / Q000494:pharmacology; D017228:Hepatocyte Growth Factor; D007371:Interferon-gamma / Q000494:pharmacology; D008089:Listeria monocytogenes / Q000378:metabolism / Q000472:pathogenicity; D008088:Listeriosis / Q000201:enzymology* / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000187:drug effects; D051379:Mice; D018345:Mice, Knockout; D009569:Nitric Oxide / Q000096:biosynthesis; D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D013154:Spleen / Q000382:microbiology
chemical_list: D006133:Growth Substances; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; C082332:macrophage stimulating protein; D009569:Nitric Oxide; D017228:Hepatocyte Growth Factor; D007371:Interferon-gamma; C080835:RON protein; D020794:Receptor Protein-Tyrosine Kinases