Motor perseveration is an early sign of Parkinson's disease.
Perseveration in the generation of random motor behavior was examined by means of the Vienna perseverance task in groups of de novo (n = 18) and treated (n = 18) patients with early PD, and in control subjects (n = 18). In comparison with control subjects, both the de novo and treated patients with PD were relatively unable to generate random motor sequences, indicating a decreased ability to switch cortical behavioral programs in PD. An impairment of random motor generation appears to be a very early feature of PD.
Stoffers
D
D
Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. d.stoffers@vumc.nl
Berendse
H W
HW
Deijen
J B
JB
Wolters
E C
EC
D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012691:Serial Learning / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D000978:Antiparkinson Agents