Lnk adaptor: novel negative regulator of B cell lymphopoiesis.
Originally thought to have the functions now ascribed to the linker for activation of T cells protein (LAT), Lnk is coming into its own as an adaptor protein that mediates signaling through several receptor pathways. An essential role for Lnk in B cell development and maturation was recently uncovered by Perlmutter and colleagues. Rudd discusses the role of Lnk in B cells and hypothesizes a mechanism whereby Lnk, and its closely related protein family members, the adaptor molecules containing pleckstrin homology (PH) and Src-homology 2 (SH2) domains (APS), and Src-homology 2-B protein (SH2-B), may mediate signal promotion or attenuation.
Rudd
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Department of Pathology, Harvard Medical School, Boston MA 02115, USA. Christopher_Rudd@dfci.harvard.edu
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D018909:src Homology Domains / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C107249:SH2B2 protein, human; C490778:SH2B3 protein, human; C488162:Sh2b2 protein, rat