Bacterial ghosts as carrier and targeting systems.
Bacterial ghosts are empty cell envelopes originating from Gram-negative bacteria. They have a natural outer surface make-up which provides them with the original targeting functions of the bacteria they are derived from and are thus able to bind to and/or are taken up by specific cells or tissues of animal, human or plant origin. The extended bacterial ghost system represents a platform technology for creating new qualities in non-living carriers which can be used for the specific targeting of drugs, DNA or other compounds to overcome toxic or non-desired obstacles. Freeze dried bacterial ghosts are stable without the requirement of a cold chain and can be effectively administered orally and aerogenically as drug carriers. The new system is an alternative to liposomes and may have an advantage due to its higher specificity for targeting specific tissues, its easy method of production and its versatility in entrapping and packaging various compounds in different compartments of the carriers.
Lubitz
W
W
Institute of Microbiology and Genetics, University of Vienna, Dr. Bohrgasse 9, A-1030 Wien, Austria. lubitz@bird-c.com
D000818:Animals; D010584:Bacteriophage phi X 174; D002462:Cell Membrane / Q000821:virology; D004337:Drug Carriers / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006090:Gram-Negative Bacteria / Q000821:virology; D006801:Humans; D010743:Phospholipids / Q000008:administration & dosage / Q000627:therapeutic use
D004337:Drug Carriers; D010743:Phospholipids