Severe axonal polyneuropathy after a FK506 overdosage in a lung transplant recipient.
FK506-induced polyneuropathies are rarely encountered. We report a case of axonal sensorimotor polyneuropathy in a lung transplant recipient that occurred during a FK506 overdosage. Onset was acute in the form of severe areflexic tetraparesis and resolution was observed after reduction of dosage. Because of increasing use of FK506 in solid organ transplantation, caution should be paid with FK506 dosage monitoring in cases of peripheral nervous system symptoms.
Boukriche
Y
Y
Department of Neurology, Beaujon Hospital, 100 Boulevard du Général Leclerc 92110, Clichy, France.
Brugière
O
O
Castier
Y
Y
Stocco
J
J
Mal
H
H
Fournier
M
M
D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000139:chemically induced* / Q000503:physiopathology; D011782:Quadriplegia / Q000139:chemically induced / Q000503:physiopathology; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D016559:Tacrolimus