title: Outcome of patients with hypertrophic obstructive cardiomyopathy after percutaneous transluminal septal myocardial ablation and septal myectomy surgery.
abstract: OBJECTIVE
  This study was conducted to evaluate follow-up results in patients with hypertrophic obstructive cardiomyopathy (HOCM) who underwent either percutaneous transluminal septal myocardial ablation (PTSMA) or septal myectomy.
  
  
  BACKGROUND
  Controversy exists with regard to these two forms of treatment for patients with HOCM.
  
  
  METHODS
  Of 51 patients with HOCM treated, 25 were treated by PTSMA and 26 patients via myectomy. Two-dimensional echocardiograms were performed before both procedures, immediately afterwards and at a three-month follow-up. The New York Heart Association (NYHA) functional class was obtained before the procedures and at follow-up.
  
  
  RESULTS
  Interventricular septal thickness was significantly reduced at follow-up in both groups (2.3 +/- 0.4 cm vs. 1.9 +/- 0.4 cm for septal ablation and 2.4 +/- 0.6 cm vs. 1.7 +/- 0.2 cm for myectomy, both p < 0.001). Estimated by continuous-wave Doppler, the resting pressure gradient (PG) across the left ventricular outflow tract (LVOT) significantly decreased immediately after the procedures in both groups (64 +/- 39 mm Hg vs. 28 +/- 29 mm Hg for PTSMA, 62 +/- 43 mm Hg vs. 7 +/- 7 mm Hg for myectomy, both p < 0.0001). At three-month follow-up, the resting PG remained lower in the PTSMA and myectomy groups (24 +/- 19 mm Hg and 11 +/- 6 mm Hg, respectively, vs. those before procedures, both p < 0.0001). The NYHA functional class was also significantly improved in both groups (3.5 +/- 0.5 vs. 1.9 +/- 0.7 for PTSMA, 3.3 +/- 0.5 vs. 1.5 +/- 0.7 for myectomy, both p < 0.0001).
  
  
  CONCLUSIONS
  Both myectomy and PTSMA reduce LVOT obstruction and significantly improve NYHA functional class in patients with HOCM. However, there are benefits and drawbacks for each therapeutic method that must be counterbalanced when deciding on treatment for LVOT obstruction.
authors.affiliation: Cardiovascular Imaging Center, Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: J X
authors.initials: JX
authors.lastname: Qin
authors.forename: T
authors.initials: T
authors.lastname: Shiota
authors.forename: H M
authors.initials: HM
authors.lastname: Lever
authors.forename: S R
authors.initials: SR
authors.lastname: Kapadia
authors.forename: M
authors.initials: M
authors.lastname: Sitges
authors.forename: D N
authors.initials: DN
authors.lastname: Rubin
authors.forename: F
authors.initials: F
authors.lastname: Bauer
authors.forename: N L
authors.initials: NL
authors.lastname: Greenberg
authors.forename: D A
authors.initials: DA
authors.lastname: Agler
authors.forename: J K
authors.initials: JK
authors.lastname: Drinko
authors.forename: M
authors.initials: M
authors.lastname: Martin
authors.forename: E M
authors.initials: EM
authors.lastname: Tuzcu
authors.forename: N G
authors.initials: NG
authors.lastname: Smedira
authors.forename: B
authors.initials: B
authors.lastname: Lytle
authors.forename: J D
authors.initials: JD
authors.lastname: Thomas
mesh_terms: D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000601:surgery*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D010043:Outcome and Process Assessment, Health Care; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D014694:Ventricular Outflow Obstruction / Q000000981:diagnostic imaging / Q000601:surgery