Implications of Salmonella-induced nitric oxide (NO) for host defense and vaccines: NO, an antimicrobial, antitumor, immunosuppressive and immunoregulatory molecule.
Attenuated Salmonella induce immunosuppressive, microbicidal and tumoricidal macrophages in mice. All three effects are mediated by activated macrophages producing nitric oxide (NO). NO is induced by the innate immune response pathway involving IL-12, NK cells and IFN-gamma in response to infection. NO has beneficial and detrimental effects on the host.
Eisenstein
T K
TK
Department of Microbiology and Immunology, and Center for Substance Abuse Research, 3400 North Broad Street, Temple University School of Medicine, Philadelphia, PA 19140, USA. tke@astro.temple.edu
D000818:Animals; D006801:Humans; D007165:Immunosuppression Therapy; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008809:Mice, Inbred C3H; D009369:Neoplasms / Q000276:immunology; D009569:Nitric Oxide / Q000096:biosynthesis*; D010954:Plasmacytoma / Q000276:immunology; D012475:Salmonella / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000517:prevention & control*; D022562:Salmonella Vaccines / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology
D022562:Salmonella Vaccines; D014613:Vaccines, Attenuated; D009569:Nitric Oxide