title: Dysfunction of the lower urinary and distal gastrointestinal tracts in pediatric patients with known spinal cord problems.
abstract: Destruction of the urinary tract in children with elimination, storage, and holding dysfunction of the lower urinary and the distal GI tracts is caused primarily by high intravesical pressure. UTI accelerates this process. The LPP and the status of the urethral control mechanism and its relationship to the detrusor are the primary determinants of intravesical pressure. Intravesical pressures of more than 40 cm H2O are dangerous because they cause a pressure gradient that is transmitted proximally to the renal papillae, which results in the cessation of renal blood flow and a loss of renal function over time. Hydroureteronephrosis, VUR, UTI, urinary incontinence, and calculi formation also may occur. If these dangerously high intravesical pressures remain untreated, renal failure is likely to occur over time. These children then require dialysis or renal transplantation to survive, which is tragic and represents an enormous economic cost to society. Renal failure and upper urinary tract damage is nearly 100% preventable with early and appropriate evaluation and treatment. CIC is a crucial part of the management of these children and has been shown to be safe and effective, even in newborn boys. The use of the Credé maneuver (i.e., manual compression) to empty the bladder is obsolete and should be abandoned. The distal GI tract is inseparable from the lower urinary tract and must be treated simultaneously. Failure to treat the distal GI tract yields poor clinical results and much patient dissatisfaction and makes it difficult or impossible to treat the child's urinary tract problem successfully. Bowel-management programs must include daily high water and fiber intake, together with digital perianal stimulation or fecal extraction. Neuropathic bladder and bowel problems that are intractable to conservative medical and mechanical (i.e., CIC and digital perianal stimulation or fecal extraction, respectively) management almost always can be corrected surgically with high success rates in cooperative patients. Finally, neuropathic bladder and bowel problems can be extremely isolating and debilitating problems. Psychologic counseling and emotional support must be provided as needed. The care that these patients receive must be organized, comprehensive, and correlated with these patients' lifestyles. If these children are evaluated and treated early, they have the potential to live long, healthy, and productive lives.
authors.affiliation: Department of Urology, University of California, Los Angeles School of Medicine, USA. bchurchill@mednet.ucla.edu
authors.forename: B M
authors.initials: BM
authors.lastname: Churchill
authors.forename: R P
authors.initials: RP
authors.lastname: Abramson
authors.forename: E F
authors.initials: EF
authors.lastname: Wahl
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D002648:Child; D003106:Colon / Q000294:innervation / Q000502:physiology; D003108:Colonic Diseases / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D012002:Rectal Diseases / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D012007:Rectum / Q000294:innervation / Q000502:physiology; D013118:Spinal Cord Diseases / Q000150:complications* / Q000628:therapy; D014521:Urethra / Q000294:innervation / Q000502:physiology; D014522:Urethral Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D001743:Urinary Bladder / Q000294:innervation / Q000502:physiology; D001745:Urinary Bladder Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy