Foreign body reaction with delayed extrusion of ganciclovir implant in a patient with immune recovery vitritis syndrome.
OBJECTIVE
To report a case of delayed extrusion of primary ganciclovir implants in a patient with immune recovery vitritis syndrome.


METHODS
Interventional case report. A 54-year-old HIV positive male patient with immune recovery vitritis syndrome had spontaneous extrusion of bilateral ganciclovir devices 4 years after primary implantation.


RESULTS
The extruded ganciclovir implants were removed from both eyes, and removal was complicated by vitreous hemorrhage in one eye. Histopathological examination of the extruded implant, LE, showed marked inflammation and evidence of foreign body reaction.


CONCLUSIONS
Excess inflammation in eyes with immune recovery vitritis syndrome may trigger a foreign body reaction that results in a delayed extrusion of primary ganciclovir implants. The site of ganciclovir implants in patients with immune recovery vitritis syndrome should be regularly inspected for eroding struts to prevent secondary endophthalmitis.
Taguri
Abdel Hakim
AH
Princess Alexandra Eye Pavilion, Edinburgh, Scotland, United Kingdom. taguri@hotmail.com
Dhillon
Baljean
B
Wharton
Stephen B
SB
Kamal
Ahmed
A
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000998:Antiviral Agents; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy; D004343:Drug Implants / Q000009:adverse effects*; D005128:Eye Diseases / Q000150:complications*; D005548:Foreign-Body Migration / Q000209:etiology*; D005549:Foreign-Body Reaction / Q000209:etiology*; D015774:Ganciclovir; D006801:Humans; D008269:Macular Edema / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014822:Vitreous Body / Q000473:pathology*
D000998:Antiviral Agents; D004343:Drug Implants; D015774:Ganciclovir