title: Rapid improvement of icterus and pruritus by the oral administration of colestimide in two cases of drug-induced hepatitis.
abstract: We report two cases of drug-induced hepatitis refractory to therapy of ursodeoxycholic acid and prednisolone, who were relieved of icterus and pruritus immediately by the oral administration of colestimide. Their liver dysfunction was not improved, by withdrawal of causative drugs or by treatment with prednisolone and ursodeoxycholic acid. Colestimide (3.0 g/day), a strong basic anion-exchange resin, was orally taken before breakfast and evening meal, leading to rapid and complete relief of icterus and pruritus. These cases suggested that colestimide would be useful for patients with cholestasis in drug-induced hepatitis, because this agent has few side effects and it is easy to take.
authors.affiliation: Department of Gastroenterology, Nayoro City General Hospital, Nayoro, Hokkaido.
authors.forename: M
authors.initials: M
authors.lastname: Tani
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: S
authors.initials: S
authors.lastname: Yokohama
authors.forename: M
authors.initials: M
authors.lastname: Inaba
authors.forename: H
authors.initials: H
authors.lastname: Kubota
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000837:Anion Exchange Resins / Q000627:therapeutic use*; D000931:Antidotes / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000188:drug therapy*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D004811:Epichlorohydrin; D019304:Ethinyl Estradiol-Norgestrel Combination / Q000009:adverse effects; D005260:Female; D006801:Humans; D007093:Imidazoles; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000139:chemically induced* / Q000188:drug therapy*; D012117:Resins, Synthetic; D016896:Treatment Outcome
chemical_list: D000837:Anion Exchange Resins; D000931:Antidotes; D003277:Contraceptives, Oral, Combined; D007093:Imidazoles; D012117:Resins, Synthetic; C417427:colestimide; D004811:Epichlorohydrin; D019304:Ethinyl Estradiol-Norgestrel Combination