title: Endoxin:a major factor regulating cardiovascular system.
abstract: Endoxin is a factor with a digitalis-like biological activity. It is a Na+ pump inhibitor and may be an endogenous medium of digitalis receptor. There are abnormal plasma levels of endoxin in some pathophysiologic states such as hypertension, acute myocardial infarction, arrhythmia, heart failure, etc. Some studies have demonstrated that the abnormal endoxin levels may be implicated in pathogenesis of these diseases or pathophysiologic process involved. Therefore, to clarify the effects of endoxin has much significance in understanding pathogenesis, prevention and treatment of hypertension and other cardiovascular diseases.
authors.affiliation: Department of Cardiology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, China. editorys@mail.ahwhptt.net.cn
authors.forename: Y S
authors.initials: YS
authors.lastname: Ke
mesh_terms: D000818:Animals; D002298:Cardenolides; D006332:Cardiomegaly / Q000378:metabolism; D002319:Cardiovascular System / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000378:metabolism; D004077:Digoxin; D004791:Enzyme Inhibitors; D006331:Heart Diseases / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism; D011660:Pulmonary Heart Disease / Q000378:metabolism; D012503:Saponins / Q000096:biosynthesis; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
chemical_list: D002298:Cardenolides; D004791:Enzyme Inhibitors; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase