Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice.
Mammalian female fertility depends on complex interactions between the ovary and the extraovarian environment (e.g., the hypothalamic-hypophyseal ovarian axis). The role of plasma lipoproteins in fertility was examined using HDL-receptor SR-BI knockout (KO) mice. SR-BI KO females have abnormal HDLs, ovulate dysfunctional oocytes, and are infertile. Fertility was restored when the structure and/or quantity of abnormal HDL was altered by inactivating the apoAI gene or administering the cholesterol-lowering drug probucol. This suggests that abnormal lipoprotein metabolism can cause murine infertility--implying a functional hepatic-ovarian axis--and may contribute to some forms of human female infertility.
Miettinen
H E
HE
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Rayburn
H
H
Krieger
M
M
D000818:Animals; D016632:Apolipoprotein A-I / Q000378:metabolism; D002352:Carrier Proteins; D004268:DNA-Binding Proteins / Q000502:physiology; D005260:Female; D007247:Infertility, Female / Q000209:etiology*; D008074:Lipoproteins / Q000378:metabolism*; D008075:Lipoproteins, HDL; D051379:Mice; D018345:Mice, Knockout; D016601:RNA-Binding Proteins; D018110:Receptors, Lipoprotein / Q000502:physiology*
D016632:Apolipoprotein A-I; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D016601:RNA-Binding Proteins; C499308:Rag2 protein, mouse; D018110:Receptors, Lipoprotein; C064655:V(D)J recombination activating protein 2; C031616:high density lipoprotein receptors; C075197:high density lipoprotein binding protein