Membrane repair: Ca(2+)-elicited lysosomal exocytosis.
Cells in exposed positions are subject to injury and therefore need membrane repair mechanisms. Ca(2+) entry inevitably follows membrane rupture and recent studies indicate that this elicits repair via Ca(2+)-activated exocytosis of lysosomes, regulated by lysosomal synaptotagmin VII.
Gerasimenko
J V
JV
MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Gerasimenko
O V
OV
Petersen
O H
OH
D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004705:Endocytosis; D005089:Exocytosis; D008247:Lysosomes / Q000378:metabolism*
D002118:Calcium