title: Cognitive correlates of human brain aging: a quantitative magnetic resonance imaging investigation.
abstract: The relations between age-related changes in brain structure and neuropsychological test performance in 320 elderly nonclinical volunteers (ages 66-90) were examined by using quantitative MRI data and measures of attention, information processing speed, language, memory, and visuospatial ability. Final path analyses revealed significant brain-behavior relationships for two of the six cognitive measures: the Trail Making Test part B and visual delayed memory. Poorer performance on Trails B was associated with smaller cerebral hemisphere volumes and larger volumes of peripheral CSF, lateral ventricles, and third ventricle. Poorer recall on visual delayed memory was associated with larger volumes of the lateral ventricles and third ventricle. The findings demonstrate a relationship between age-related changes in brain structure and an age-related decline in attention, psychomotor speed, and visual delayed memory. The neurobiological basis for this relationship requires further investigation.
authors.affiliation: Departments of Psychiatry and of Neurology, Henry Ford Health System, Detroit, Michigan 48202, USA. ecoffey1@hfhs.org
authors.forename: C E
authors.initials: CE
authors.lastname: Coffey
authors.forename: G
authors.initials: G
authors.lastname: Ratcliff
authors.forename: J A
authors.initials: JA
authors.lastname: Saxton
authors.forename: R N
authors.initials: RN
authors.lastname: Bryan
authors.forename: L P
authors.initials: LP
authors.lastname: Fried
authors.forename: J F
authors.initials: JF
authors.lastname: Lucke
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology* / Q000523:psychology; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011594:Psychometrics; D012016:Reference Values