title: [Anesthesiological support of interventions for cancer with intraoperative radio- and hypoxic radiotherapy].
abstract: This clinical study was carried out in 195 cancer patients subjected to extensive interventions with intraoperative irradiation, including 19 cases with exposure under total gaseous hypoxia in order to increase the tolerance of exposed normal tissues to ionizing radiation. Multicomponent total anesthesia included kininogenesis inhibitor contrycal, providing full-value controlled protection of the patient from combined surgical and radiation aggression with minimum toxicity. Method for attaining and maintaining the preset (radioprotective) level of hypoxemia for needed time is described. Optimal scheme was developed for monitoring vital functions during isolation of a narcotized patient under forced ventilation of the lungs in an enclosed ward for irradiation. Monitoring was carried out using transcutaneous pO2 and pCO2 measurements, pulse oximeter, and ECG. Radioprotective level of hypoxemia (pO2 27.7 +/- 9.6 mm Hg) was well tolerated. No complications of anesthesia, surgery, radiotherapy sessions, or hypoxia were recorded.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Donskova
authors.forename: N A
authors.initials: NA
authors.lastname: Osipova
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D007611:Aprotinin / Q000008:administration & dosage / Q000627:therapeutic use; D001785:Blood Gas Monitoring, Transcutaneous; D001786:Blood Glucose / Q000032:analysis; D003131:Combined Modality Therapy; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D000860:Hypoxia; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009369:Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D015842:Serine Proteinase Inhibitors; D007611:Aprotinin; D006854:Hydrocortisone