Synthesis and biological activity of O-acyl and O-alkyl chelidonine derivatives.
A group of 11 derivatives of chelidonine was obtained by acylations and/or alkylations of the secondary hydroxyl group with the aim of testing their biological activity. This paper focuses on the new derivatives influence on CNS in mice. The highest activity was observed for compounds 2c, 3c and 4, which produced antinociceptive and antiserotoninergic effects, not recorded for the parent alkaloid 1.
Grynkiewicz
G
G
Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warsaw, Poland. gryn@stratus.ifarm.waw.pl
Chojecka-Koryn
E
E
Gadzikowska
M
M
Chodkowska
A
A
Jagiełło-Wójtowicz
E
E
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D002490:Central Nervous System / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010617:Phenanthridines; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D000470:Alkaloids; D000700:Analgesics; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; C450187:O-(p-nitrobenzoyl)chelidonine; D010616:Phenanthrenes; D010617:Phenanthridines; D012702:Serotonin Antagonists; C062047:chelidonine