Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10.
The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.
Sonnenberg-Riethmacher
E
E
Zentrum für Molekulare Neurobiologie, Universität Hamburg, Falkenried 94, 20251, Hamburg, Germany.
Miehe
M
M
Stolt
C C
CC
Goerich
D E
DE
Wegner
M
M
Riethmacher
D
D
D017209:Apoptosis; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005727:Ganglia, Spinal / Q000196:embryology* / Q000378:metabolism*; D005819:Genetic Markers; D006579:Heterozygote; D006609:High Mobility Group Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D006720:Homozygote; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007763:Lac Operon; D008856:Microscopy, Fluorescence; D009432:Neural Crest / Q000166:cytology; D017933:Peripheral Nervous System / Q000196:embryology*; D017434:Protein Structure, Tertiary; D055757:SOXE Transcription Factors; D013997:Time Factors; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D005819:Genetic Markers; D006609:High Mobility Group Proteins; D055757:SOXE Transcription Factors; D014157:Transcription Factors