title: Scaling laws for wall shear stress through stenoses under steady and pulsatile flow conditions.
abstract: Most patients with atherosclerosis exhibit isolated stenoses of one or more epicardial coronary arteries. The wall shear stresses produced in high-grade stenosis are important in the understanding of atheromatous plaque rupture and thrombosis. This study is designed to establish a method which can be used to scale the different wall shear stresses obtained under different flow conditions to be normalized and subsequently collapsed on to a single general curve. The simulations include both steady and pulsatile flow. The reduced area percentages of the stenoses studied are 50, 75 and 90 per cent. Scaling laws for steady and pulsatile flow conditions are proposed and presented. It can be found from the results that the scaling analysis for pulsatile flow conditions is more complicated than for steady flow conditions and is restricted to, and only valid at, certain time intervals.
authors.affiliation: Thermal and Fluids Engineering Division, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore.
authors.forename: I P
authors.initials: IP
authors.lastname: Chua
authors.forename: S C
authors.initials: SC
authors.lastname: Yu
authors.forename: Q
authors.initials: Q
authors.lastname: Xue
mesh_terms: D001161:Arteriosclerosis / Q000503:physiopathology*; D003251:Constriction, Pathologic; D015444:Exercise; D006801:Humans; D008954:Models, Biological; D011673:Pulsatile Flow