title: Dosage of lactate in the cerebrospinal fluid in infectious diseases of the central nervous system.
abstract: This paper analyzes the diagnosis aid of the dosage of lactate in the cerebrospinal fluid (CSF) in infectious diseases of the central nervous system (CNS). We analyzed prospectively 130 samples of CSF of 116 patients with diagnoses of infectious processes in the CNS. The 130 samples of CSF were divided into five groups: 28 samples of the control group, 40 of bacterial meningitis, 22 of viral meningitis, 16 of fungal meningitis and 24 of patients presenting acquired immune deficiency syndrome (AIDS). The concentration of lactate in the CSF was elevated in the group of patients with bacterial meningitis (average = 46.2 mg/dL), fungal meningitis (average = 27.3 mg/dL) and in the AIDS group (average = 23.5 mg/dL). In the control group and viral meningitis group the lactate content in the CSF presented the reference rates according to the employed method. The lactate dosage in the CSF presented a negative correlation with glycorrhachia and positive correlation with the cellularity and total proteins of the CSF. We conclude that the lactate dosage in the CSF, although unspecific, helps to distinguish the infectious processes of the CNS.
authors.affiliation: Centro de Investigações em Neurologia, LIM15, Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. lsflcr@terra.com.br
authors.forename: H L
authors.initials: HL
authors.lastname: Cabeça
authors.forename: H R
authors.initials: HR
authors.lastname: Gomes
authors.forename: L R
authors.initials: LR
authors.lastname: Machado
authors.forename: J A
authors.initials: JA
authors.lastname: Livramento
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007773:Lactates / Q000134:cerebrospinal fluid*; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid*; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid; D016921:Meningitis, Fungal / Q000134:cerebrospinal fluid; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D007773:Lactates; D005947:Glucose