Leukotoxins of gram-negative bacteria.
Leukotoxins are a group of exotoxins that produce their primary toxic effects against leukocytes, especially polymorphonuclear cells (PMNs). Leukotoxins include a variety of chemicals ranging from 9,10-epoxy 12-octadecenoate, a fatty acid derivative secreted by leukocytes themselves, to proteins such as RTX (repeats in toxin). This review focuses on leukotoxins of three species of gram-negative bacteria, Mannheimia (Pasteurella) haemolytica, Actinobacillus actinomycetemcomitans, and Fusobacterium necrophorum.
Narayanan
Sanjeev Kumar
SK
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, 1800 Denison Avenue, Manhattan, KS 66506-5606, USA.
Nagaraja
T G
TG
Chengappa
M M
MM
Stewart
George C
GC
D016976:Aggregatibacter actinomycetemcomitans / Q000378:metabolism / Q000472:pathogenicity; D001427:Bacterial Toxins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D005098:Exotoxins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D005675:Fusobacterium necrophorum / Q000378:metabolism / Q000472:pathogenicity; D006090:Gram-Negative Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D016978:Mannheimia haemolytica / Q000378:metabolism / Q000472:pathogenicity; D014774:Virulence
D001427:Bacterial Toxins; D005098:Exotoxins; C018579:leukotoxin