title: Crystal structure of [Cu(N-quinolin-8-yl-p-toluenesulfonamidate)(2)]: study of its interaction with DNA and hydrogen peroxide.
abstract: A new copper complex with N-quinolin-8-yl-p-toulenesulfonamide has been prepared and characterised. The compound crystallises in the triclinic system, space group P1, with a=13.457(3), b=15.067(5), c=18.589(3) A; alpha=112.05(2), beta=93.92(2), gamma=108.30(2) degrees and Z=4. The geometry of the Cu(II) ion is distorted square planar. The N-quinolin-8-yl-p-toulenesulfonamidate anion behaves as a bidentate ligand through the N(sulfonamidate)and N(quinoline) atoms. The complex does not cleave DNA in the presence of hydrogen peroxide.
authors.affiliation: Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Salamanca, Campus Unamuno, 37007 Salamanca, Spain. bmacias@gugu.usal.es
authors.forename: Benigno
authors.initials: B
authors.lastname: Macías
authors.forename: María V
authors.initials: MV
authors.lastname: Villa
authors.forename: Emilio
authors.initials: E
authors.lastname: Fiz
authors.forename: Isabel
authors.initials: I
authors.lastname: García
authors.forename: Alfonso
authors.initials: A
authors.lastname: Castiñeiras
authors.forename: Marta
authors.initials: M
authors.lastname: Gonzalez-Alvarez
authors.forename: Joaquín
authors.initials: J
authors.lastname: Borrás
mesh_terms: D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide / Q000737:chemistry*; D006868:Hydrolysis / Q000187:drug effects; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D010957:Plasmids; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis; D013449:Sulfonamides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: C447644:Cu(N-quinolin-8-yl-p-toluenesulfonamidate)(2); D009942:Organometallic Compounds; D011804:Quinolines; D013449:Sulfonamides; D003300:Copper; D004247:DNA; D006861:Hydrogen Peroxide