Immunity to placental malaria. III. Impairment of interleukin(IL)-12, not IL-18, and interferon-inducible protein-10 responses in the placental intervillous blood of human immunodeficiency virus/malaria-coinfected women.
Pregnant women are highly susceptible to malaria, and human immunodeficiency virus (HIV) infection increases this susceptibility. In our previous studies, placental malaria (PM), HIV infection, and HIV/PM coinfection were all associated with decreased interferon (IFN)-gamma production by maternal placental (intervillous) blood mononuclear cells (IVBMC). This study investigated whether in vitro production of the IFN-gamma regulatory cytokines interleukin (IL)-12 and IL-18 and the chemokine IFN-inducible protein (IP)-10 by IVBMC is altered in women who have been exposed to malaria and are infected with HIV. IL-12 production from IVBMC was significantly lower in HIV-positive women, regardless of PM status, in contrast to HIV-negative, PM-negative women. IL-18 and IP-10 production by IVBMC was reduced in HIV-positive, PM-negative women but elevated in HIV-positive, PM-positive women. These results reveal a substantial impairment of IL-12 production by IVBMC in HIV-positive women, implicating this cytokine as a potentially critical regulator of malaria antigen-specific IFN-gamma responses in HIV-infected and HIV/PM-coinfected women.
Chaisavaneeyakorn
Sujittra
S
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Moore
Julie M
JM
Otieno
Juliana
J
Chaiyaroj
Sansanee C
SC
Perkins
Douglas J
DJ
Shi
Ya Ping
YP
Nahlen
Bernard L
BL
Lal
Altaf A
AA
Udhayakumar
Venkatachalam
V
D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000097:blood*; D002824:Chorionic Villi / Q000098:blood supply / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D020382:Interleukin-18 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D007630:Kenya / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D010920:Placenta / Q000098:blood supply / Q000276:immunology*; D010922:Placenta Diseases / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D011247:Pregnancy
D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D020382:Interleukin-18; D007378:Interleukins; D018664:Interleukin-12; D007371:Interferon-gamma