Photosensitization and mutation induced in Escherichia coli and Saccharomyces cerevisiae strains by dorstenin, a psoralen analog isolated from Dorstenia bahiensis.
Dorstenin, 5-[3-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-butoxy]-7H-furo[3, 2-g] benzopyran-7-one, is a psoralen analog recently isolated from Dorstenia species (Moraceae). In order to characterize its biological activity, its photosensitizing and mutational properties were measured in wild-type E. coli and S. cerevisiae and also in strains carrying mutations which affect DNA repair. Compared to the high activities of psoralen and bergapten, dorstenin showed lower genotoxic effect.
Lopes
D
D
EMBRAPA- Agroindústria de Alimentos, Rio de Janeiro, Brazil.
Oliveira
R R
RR
Kaplan
M A
MA
Lage
C S
CS
Leitão
A C
AC
D000078223:5-Methoxypsoralen; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D005363:Ficusin / Q000302:isolation & purification / Q000494:pharmacology*; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008027:Light; D008730:Methoxsalen / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D029586:Moraceae; D016296:Mutagenesis / Q000187:drug effects; D009152:Mutagenicity Tests; D017319:Photosensitizing Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics
D011564:Furocoumarins; D017319:Photosensitizing Agents; D010936:Plant Extracts; C452761:dorstenin; D000078223:5-Methoxypsoralen; D005363:Ficusin; D008730:Methoxsalen