title: Oral bacterial therapy promotes recovery from acute diarrhea in children.
abstract: Lactobacilli in the intestines play an important role in developing natural defenses against both intestinal bacterial and viral infections. So a prospective clinical study was carried out at Cathay General Hospital to determine the effect of Lactobacillus acidophilus and Bifidobacterium infantis on the course of acute diarrhea in hospitalized children. Altogether 100 children between 6 and 60 months of age were collected and randomly allocated into 2 groups. Study group (n = 50) was given Infloran Berna, which contains 10(9) viable Lactobacillus acidophilus and 10(9) Bifidobacterium infantis, one capsule tid for 4 days and control group (n = 50) received parenteral rehydration only without any medication. Only 20 stool cultures in study group had positive culture results for Lactobacillus or Bifidobacterium. All children were evaluated for the degree of dehydration before rehydration. The clinical course of diarrhea was followed during the treatment period. Features on admission were similar between the study group and control group in age, duration of diarrhea at home, serum sodium & potassium and dehydration degree. The duration of diarrhea was defined as the time until the last appearance of watery stool. There was no difference between the study group and control group in the frequency of diarrhea stools on the day before admission (p > 0.05). However, the frequency of diarrhea for study group improved on the first and second day of hospitalization with statistical difference (p < 0.01). The duration of diarrhea during hospitalization in study group also decreased (3.1 vs. 3.6 days, p < 0.01). Oral bacterial therapy is an effective adjuvant therapy in rotavirus positive and negative children with diarrhea and can safely be administered during an episode of acute diarrhea.
authors.affiliation: Department of Pediatrics, Cathay General Hospital, 280, Section 4, Jen-Ai Road, Taipei, Taiwan.
authors.forename: M C
authors.initials: MC
authors.lastname: Lee
authors.forename: L H
authors.initials: LH
authors.lastname: Lin
authors.forename: K L
authors.initials: KL
authors.lastname: Hung
authors.forename: H Y
authors.initials: HY
authors.lastname: Wu
mesh_terms: D000208:Acute Disease; D001644:Bifidobacterium; D002675:Child, Preschool; D003968:Diarrhea, Infantile / Q000517:prevention & control / Q000628:therapy* / Q000821:virology; D005260:Female; D005440:Fluid Therapy; D005759:Gastroenteritis / Q000150:complications* / Q000628:therapy* / Q000821:virology; D006801:Humans; D007223:Infant; D007779:Lactobacillus acidophilus; D008297:Male; D011446:Prospective Studies; D015532:Rehydration Solutions; D012400:Rotavirus Infections / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D015532:Rehydration Solutions