The involvement of class Ib molecules in the host response to infection with Salmonella and its relevance to autoimmunity.
Class I molecules with limited polymorphism have been implicated in the host response to infectious agents. Following infection with Salmonella typhimurium, mice develop a CD8+ CTL response that specifically recognizes bacteria infected cells. An immunodominant component of the CTL response recognizes a peptide epitope derived from the Salmonella GroEL molecule that is presented by the non-polymorphic MHC class Ib molecule Qa-1. T cells recognizing the bacterial peptide also cross-recognize a homologous peptide from the mammalian hsp60 molecule. Since Qa-1 has a functional equivalent in humans, this observation may be relevant not only to the host response involved in clearing infection but also in understanding the link between infection with Gram-negative pathogens and autoimmune disease.
Soloski
M J
MJ
Division of Rheumatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA. mski@jhmi.edu
Metcalf
E S
ES
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000971:Antineoplastic Combined Chemotherapy Protocols; D015551:Autoimmunity; D002945:Cisplatin; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007069:Ifosfamide; D051379:Mice; D008810:Mice, Inbred C57BL; D016685:Mitomycin; D012475:Salmonella / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology* / Q000382:microbiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens; D016685:Mitomycin; D002945:Cisplatin; D007069:Ifosfamide