title: PRINTS and PRINTS-S shed light on protein ancestry.
abstract: The PRINTS database houses a collection of protein fingerprints. These may be used to make family and tentative functional assignments for uncharacterised sequences. The September 2001 release (version 32.0) includes 1600 fingerprints, encoding approximately 10 000 motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. In addition to its continued steady growth, we report here its use as a source of annotation in the InterPro resource, and the use of its relational cousin, PRINTS-S, to model relationships between families, including those beyond the reach of conventional sequence analysis approaches. The database is accessible for BLAST, fingerprint and text searches at http://www.bioinf.man.ac.uk/dbbrowser/PRINTS/.
authors.affiliation: School of Biological Sciences, The University of Manchester, Manchester M13 9PT, UK. attwood@bioinf.man.ac.uk
authors.forename: T K
authors.initials: TK
authors.lastname: Attwood
authors.forename: M J
authors.initials: MJ
authors.lastname: Blythe
authors.forename: D R
authors.initials: DR
authors.lastname: Flower
authors.forename: A
authors.initials: A
authors.lastname: Gaulton
authors.forename: J E
authors.initials: JE
authors.lastname: Mabey
authors.forename: N
authors.initials: N
authors.lastname: Maudling
authors.forename: L
authors.initials: L
authors.lastname: McGregor
authors.forename: A L
authors.initials: AL
authors.lastname: Mitchell
authors.forename: G
authors.initials: G
authors.lastname: Moulton
authors.forename: K
authors.initials: K
authors.lastname: Paine
authors.forename: P
authors.initials: P
authors.lastname: Scordis
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D030562:Databases, Protein; D019143:Evolution, Molecular; D016247:Information Storage and Retrieval; D020407:Internet; D011506:Proteins / Q000235:genetics* / Q000502:physiology; D016415:Sequence Alignment
chemical_list: D011506:Proteins