Semantic acquisition without memories: evidence from transient global amnesia.
Transient global amnesia (TGA), characterised by a profound anterograde amnesia, is a model of interest to study the acquisition of novel meanings independent of episodic functioning. Three patients were tested during a TGA attack, two in the early recovery phase and the third during the acute phase of TGA, with a semantic priming task involving a restructuring process of conceptual knowledge. During TGA, all patients demonstrated priming effects. Results obtained the day after the episode with the same task showed that these effects persisted at least one day. Episodic memory seems not to be critical for the formation of novel connections among unrelated semantic representations, in accordance with Tulving's model of memory, i.e. episodic memory is not necessary for the acquisition of semantic information.
Guillery
B
B
INSERM U320, Laboratoire de Neuropsychologie, Centre Hospitalier Universitaire Côte de Nacre, 14033 Caen Cedex, France.
Desgranges
B
B
Katis
S
S
de la Sayette
V
V
Viader
F
F
Eustache
F
F
D000208:Acute Disease; D000368:Aged; D020236:Amnesia, Transient Global / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D007807:Language Tests; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D020127:Recovery of Function / Q000502:physiology; D012660:Semantics; D013998:Time Perception / Q000502:physiology; D014705:Verbal Behavior / Q000502:physiology*