Should ICSI be the treatment of choice for all cases of in-vitro conception? Considerations of fertilization and embryo development, cost effectiveness and safety.
There is now considerable discussion whether intracytoplasmic sperm injection (ICSI) should be used in all cases of IVF. A critical and balanced view of the current literature is presented. The difficult question is how to identify men with apparently normal semen who are likely to fail to achieve a pregnancy using IVF. In conclusion, from both the safety and scientific viewpoint, ICSI should only be used in cases where success at IVF is regarded as unlikely.
Ola
B
B
Assisted Conception Unit, Birmingham Women's Hospital, Edgbaston, Birmingham B15 T2G, UK.
Afnan
M
M
Sharif
K
K
Papaioannou
S
S
Hammadieh
N
N
Barratt
C L
CL
D001755:Blastocyst / Q000502:physiology; D003362:Cost-Benefit Analysis; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012449:Safety; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects / Q000191:economics