Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats.
The present study was designed to assess the anti-inflammatory activity of hyperbaric oxygen treatment by comparing it with that of diclofenac, a nonsteroidal anti-inflammatory drug, and also to investigate whether hyperbaric oxygen treatment enhances the anti-inflammatory effect of diclofenac in carrageenan-induced paw edema which is commonly employed as an acute inflammation model in rats. Hyperbaric oxygen treatment and diclofenac (20 mg/kg) markedly reduced the carrageenan-induced paw edema in rats. In other words, they displayed anti-inflammatory activity. On the other hand, hyperbaric oxygen treatment did not consistently modify the anti-inflammatory effect of diclofenac in this model.
Sümen
G
G
Department of Underwater and Hyperbaric Medicine, Istanbul University, Istanbul Medical Faculty, 34390, Topkapi, Istanbul, Turkey.
Cimşit
M
M
Eroglu
L
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D002351:Carrageenan; D003131:Combined Modality Therapy; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000628:therapy*; D006614:Hindlimb; D006931:Hyperbaric Oxygenation; D007249:Inflammation / Q000139:chemically induced / Q000628:therapy*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D002351:Carrageenan