title: Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis.
abstract: The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied. In 11 of 23 patients, from whom only quinolone-susceptible E. coli was isolated before treatment, quinolone-resistant strains, genetically distinct from the quinolone-susceptible ones, predominated during and just after therapy. Two months after treatment, these were completely displaced by quinolone-susceptible E. coli, genetically distinct from the E. coli isolated before and during therapy. Hence, during ciprofloxacin therapy, half of the patients were transiently colonized with new, quinolone-resistant strains of E. coli.
authors.affiliation: Department of Infectious Diseases, Institut Clínic d'Infeccions i Immunologia (ICII), Villarroel 170, 08036 Barcelona, Spain. jhorcaja@clinic.ub.es
authors.forename: Juan P
authors.initials: JP
authors.lastname: Horcajada
authors.forename: Jordi
authors.initials: J
authors.lastname: Vila
authors.forename: Antonio
authors.initials: A
authors.lastname: Moreno-Martínez
authors.forename: Joaquim
authors.initials: J
authors.lastname: Ruiz
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Martínez
authors.forename: Miquel
authors.initials: M
authors.lastname: Sánchez
authors.forename: Eladio
authors.initials: E
authors.lastname: Soriano
authors.forename: Josep
authors.initials: J
authors.lastname: Mensa
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000453:epidemiology*; D019143:Evolution, Molecular; D006801:Humans; D008297:Male; D011472:Prostatitis / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin