Signal transduction. A new thread in an intricate web.
Understanding how biochemical pathways are connected in the cell is one of the big challenges facing cell biologists. In a Perspective, von Zastrow and Mostov describe new work that identifies a protein called RGS-PX1 as the linchpin that connects signal transduction activated by G protein-coupled receptors with membrane trafficking events.
von Zastrow
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Departments of Psychiatry, University of California, San Francisco, CA 94143, USA. zastrow@itsa.ucsf.edu
Mostov
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D000818:Animals; D019390:Arrestins / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D030541:Databases, Genetic; D066246:ErbB Receptors / Q000378:metabolism; D020690:GTPase-Activating Proteins / Q000737:chemistry / Q000378:metabolism*; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D020710:RGS Proteins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D058305:Sorting Nexins; D000071557:beta-Arrestins
D019390:Arrestins; D002352:Carrier Proteins; D020690:GTPase-Activating Proteins; D020710:RGS Proteins; C442319:SNX13 protein, human; D058305:Sorting Nexins; D000071557:beta-Arrestins; D066246:ErbB Receptors; D020962:Heterotrimeric GTP-Binding Proteins