Effect of topical betaxolol on acute rise of aqueous flare induced by prostaglandin E(2) in pigmented rabbits.
OBJECTIVE
To evaluate the effects of topical betaxolol on experimental ocular inflammation.


METHODS
Transcorneal diffusion of 25 microg/mL (7.09 x 10(-2) mmol/L) of prostaglandin E(2) (PGE(2)), placed in a glass cylinder, was employed to induce aqueous flare elevation in pigmented rabbits. Betaxolol was administered topically before PGE(2) application. Aqueous flare was measured with a laser flare cell meter.


RESULTS
Four-, two-, and one-time topical instillations of betaxolol inhibited the PGE(2)-induced aqueous flare elevation by 44% +/- 8%, 32 +/- 7%, and 8 +/- 6%(mean +/- SD), respectively. The inhibition of flare elevation was dependent on the number of betaxolol instillations.


CONCLUSIONS
Topical betaxolol has an inhibitory effect on PGE(2)-induced aqueous flare elevation in rabbit eyes.
Yanagisawa
S
S
Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama-shi, Toyama-ken, Japan.
Hayasaka
S
S
Zhang
X Y
XY
Hayasaka
Y
Y
Nagaki
Y
Y
Kitagawa
K
K
D000208:Acute Disease; D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D015784:Betaxolol / Q000008:administration & dosage*; D015232:Dinoprostone / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D014606:Uveitis, Anterior / Q000139:chemically induced / Q000517:prevention & control*
D000319:Adrenergic beta-Antagonists; D015232:Dinoprostone; D015784:Betaxolol