Cellular calcium homeostasis changes in lymphoma-induction by ATP iron complex.
An in vivo comparative study of 45Ca-uptake and lipid peroxidation in tissues of mice treated with ATP complex of iron and sodium salt of ATP shows that only the iron complex produces a sustained increase of intracellular calcium on the organs susceptibles to develop lymphomas. A paralled study of 59Fe-uptake from 59Fe-iron complex of ATP presents a coincidental increase of iron uptake in those organs. To prove the involvement of the calcium homeostasis change in lymphoma-induction we have studied it with the lanthanum complex of ATP. Lanthanum is a well known cellular calcium entry modifier. Based on the results, the increased and sustained entry of extracellular calcium ion appears as the cause of lymphoma-induction by the iron complex. The effects of the calcium-overload in proliferation and neoplastic transformation of lymphocytes, as well as in reducing the immuno-response induced by thymus is discussed.
Anghileri
Leopold J
LJ
Biophysics Laboratory, Faculty of Medicine, Nancy University, 54505 Vandoeuvre-les-Nancy, France. anghileri@club-internet.fr
Mayayo
Emilio
E
Domingo
José L
JL
Thouvenot
Pierre
P
D000255:Adenosine Triphosphate / Q000633:toxicity*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D058085:Iron Compounds / Q000633:toxicity*; D007504:Iron Radioisotopes; D007811:Lanthanum / Q000633:toxicity; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008223:Lymphoma / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D013363:Submandibular Gland / Q000187:drug effects / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology
D058085:Iron Compounds; D007504:Iron Radioisotopes; D007811:Lanthanum; D000255:Adenosine Triphosphate; D002118:Calcium