Complete remission of gestational choriocarcinoma with choroidal metastasis treated with systemic chemotherapy alone: case report and review of literature.
BACKGROUND
Gestational choriocarcinoma is a malignant tumor that frequently metastasizes to the highly vascularized organs such as the lung, brain, and liver via hematogenous spread. However, this tumor rarely metastasizes to the eye and only a few cases of metastasis to the choroid have been reported.


METHODS
A 17-year-old woman presented with visual field defects, decreased vision, and increasing pain in her left eye. She had undergone evacuation of a complete hydatidiform mole 32 months prior to the presentation. Ophthalmologic evaluation revealed a metastatic choroidal tumor, and a CT scan showed a metastatic tumor in the left lung. The serum hCG level was elevated at 7780 mIU/ml. A clinical diagnosis of metastatic gestational choriocarcinoma involving the choroid and lung was made. The patient received 13 courses of combination chemotherapy, resulting in complete remission. Radiotherapy and surgical treatment were unnecessary.


CONCLUSIONS
This is a very rare case of the successful treatment of gestational choriocarcinoma metastatic to the choroid using systemic chemotherapy alone.
Ino
K
K
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, 65 Tsurumai-cho, Nagoya, Showa-ku, 466-8550, Japan. kazuino@med.nagoya-u.ac.jp
Mitsui
T
T
Nomura
S
S
Kikkawa
F
F
Mizutani
S
S
D000293:Adolescent; D002822:Choriocarcinoma / Q000188:drug therapy* / Q000556:secondary*; D002830:Choroid Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D005260:Female; D006801:Humans; D011247:Pregnancy; D012074:Remission Induction; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology