Subthalamo-pallido-striatal axis: a feedback system in the basal ganglia.
Systemic administration of a dopamine D2 receptor blocker, haloperidol, but not vehicle, significantly increased the number of c-Fos-immunoreactive neurons in the globus pallidus (GP) in rats. Dual immunohistochemistry, a combination of c-Fos immunohistochemistry and retrograde tracing experiments with cholera toxin B (ChB), revealed that a subset of the c-Fos-immunoreactive GP neurons was pallidostriatal feedback neurons. Lesioning of the subthalamic nucleus (STN) by local injection of ibotenic acid inhibited the haloperidol-induced c-Fos expression in the GP neurons, suggesting that the activation of GP neurons is a result of increased excitatory drives from the STN. Therefore, the present findings are evidence of the existence of the subthalamo-pallido-striatal axis as a feedback system in the internal circuits of the basal ganglia.
Miwa
H
H
Department of Neurology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu-city, Tokyo, Japan.
Fuwa
T
T
Nishi
K
K
Kondo
T
T
D000818:Animals; D002452:Cell Count; D002772:Cholera Toxin; D003714:Denervation; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D005246:Feedback / Q000502:physiology*; D005917:Globus Pallidus / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology; D007051:Ibotenic Acid / Q000494:pharmacology; D007150:Immunohistochemistry; D008297:Male; D017072:Neostriatum / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009434:Neural Pathways / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020531:Subthalamic Nucleus / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
D018492:Dopamine Antagonists; D018690:Excitatory Amino Acid Agonists; D016760:Proto-Oncogene Proteins c-fos; D007051:Ibotenic Acid; D002772:Cholera Toxin; D006220:Haloperidol; D004298:Dopamine