Effects of cyclazocine and scopolamine on swim-to-platform performance in rats.
DL-Cyclazocine (0.5-2.0 mg/kg, i.p.) produced no impairment in rats' acquisition and retention of the behavior of swimming to a large visible platform in a water tank. However, cyclazocine produced a significant enhancement or potentiation of the impairment in swim-to-platform behavior produced by scopolamine. Since cyclazocine has previously been shown to abolish serotonin-dependent electrocortical activation (enabling it, in combination with central muscarinic blockade, to block all cortical activation), the results lend further support to the hypothesis that blockade of electrocortical activation produces dementia rather than sleep or coma as was previously believed.
Buckton
G
G
Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2, Canada.
Zibrowski
E M
EM
Vanderwolf
C H
CH
D000109:Acetylcholine / Q000378:metabolism; D000344:Afferent Pathways / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003496:Cyclazocine / Q000494:pharmacology*; D003704:Dementia / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects*; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D012601:Scopolamine / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism; D013550:Swimming / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D018727:Muscarinic Antagonists; D009292:Narcotic Antagonists; D012701:Serotonin; D012601:Scopolamine; D003496:Cyclazocine; D000109:Acetylcholine