title: Fibrin application for preventing lymphocysts after retroperitoneal lymphadenectomy in patients with gynecologic malignancies.
abstract: OBJECTIVE
  We performed a randomized, prospective trial to assess the impact of fibrin glue on the incidence of lymphocysts after systematic pelvic or pelvic and paraaortic lymphadenectomy in patients with gynecologic malignancies.
  
  
  METHODS
  Ninety-three consecutive patients with gynecologic pelvic malignancies who underwent surgery including pelvic or pelvic and paraaortic lymphadenectomy were randomized during surgery to be treated with fibrin glue or not. Serial computed tomography (CT) scans were performed during follow-up. CT findings of a smooth and thin-walled cavity filled with a water-equivalent fluid, sharply demarcated from its surroundings and without signs of infiltration were interpreted as lymphocysts.
  
  
  RESULTS
  Forty-seven patients (51%) were treated with fibrin glue and 46 (49%) were not. All 93 patients underwent pelvic lymphadenectomy; 15 patients (32%) of the fibrin group and 12 (26%) of the controls also underwent paraaortic lymphadenectomy. We found no significant differences between patients who received fibrin glue and those who did not.
  
  
  CONCLUSIONS
  Intraoperative application of fibrin glue did not reduce the rate of postoperative lymphocysts after lymphadenectomy and had no impact on any follow-up parameter. Its use seems not to be indicated in systematic gynecologic pelvic or pelvic and paraaortic lymphadenectomy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Graz, Auenbruggerplatz 14, Graz, A-8036, Austria. scholzhs@kfunigraz.ac.at
authors.forename: Heinz S
authors.initials: HS
authors.lastname: Scholz
authors.forename: Edgar
authors.initials: E
authors.lastname: Petru
authors.forename: Christoph
authors.initials: C
authors.lastname: Benedicic
authors.forename: Josef
authors.initials: J
authors.lastname: Haas
authors.forename: Karl
authors.initials: K
authors.lastname: Tamussino
authors.forename: Raimund
authors.initials: R
authors.lastname: Winter
mesh_terms: D000328:Adult; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects*; D008210:Lymphocele / Q000209:etiology / Q000517:prevention & control*; D008875:Middle Aged; D011446:Prospective Studies; D012187:Retroperitoneal Space / Q000601:surgery
chemical_list: D015718:Fibrin Tissue Adhesive