title: A randomised trial of progesterone prophylaxis after midtrimester amniocentesis.
abstract: BACKGROUND
  Midtrimester amniocentesis to investigate fetal karyotype carries a small risk of fetal loss.
  
  
  OBJECTIVE
  To test the hypothesis that progesterone prophylaxis may reduce this.
  
  
  METHODS
  A randomised controlled trial comparing a short prophylactic treatment with progesterone after amniocentesis with untreated controls.
  
  
  RESULTS
  There were no differences in frequency of miscarriage, preterm delivery or neonatal outcome.
  
  
  CONCLUSIONS
  Prophylactic progesterone treatment after amniocentesis does not improve obstetric outcome.
authors.affiliation: Institute of Gynecology, Policlinico Universitario, 98100, Messina, Italy. f.sco_corrado@tin.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Corrado
authors.forename: Corrado
authors.initials: C
authors.lastname: Dugo
authors.forename: Maria L
authors.initials: ML
authors.lastname: Cannata
authors.forename: Massimo
authors.initials: M
authors.lastname: Di Bartolo
authors.forename: Angela
authors.initials: A
authors.lastname: Scilipoti
authors.forename: Narcisio
authors.initials: N
authors.lastname: Carlo Stella
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000517:prevention & control; D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000517:prevention & control; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology / Q000517:prevention & control; D005865:Gestational Age; D006801:Humans; D007752:Obstetric Labor, Premature / Q000453:epidemiology / Q000517:prevention & control; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000517:prevention & control*; D011374:Progesterone / Q000627:therapeutic use*
chemical_list: D011374:Progesterone