title: Granular cell tumor of the canine central nervous system: two cases.
abstract: Although pure granular cell tumors have been reported in various sites in the dog, only one tumor has been reported in the central nervous system. Two dogs presented with neurologic signs had brain lesions detected by magnetic resonance imaging in the area of the olfactory bulbs and frontal cortex. In both dogs, a clinical diagnosis of a granular cell tumor was made from tissues obtained from stereotactic biopsies guided by computed tomography. Surgical removal of the tumors was followed by histopathologic, ultrastructural, and immunocytochemical characterization. Although not conclusive, these studies indicated that the granular cells were not of leucocyte origin but may have been derived from the meninges. One dog died 12 months after surgery, and the other was alive 4 months later.
authors.affiliation: Department of Pathology, Immunology, and Microbiology, School of Veterinary Medicine, University of California, Davis 95616, USA. rjhiggins@ucdavis.edu
authors.forename: R J
authors.initials: RJ
authors.lastname: Higgins
authors.forename: R A
authors.initials: RA
authors.lastname: LeCouteur
authors.forename: K M
authors.initials: KM
authors.lastname: Vernau
authors.forename: B K
authors.initials: BK
authors.lastname: Sturges
authors.forename: J E
authors.initials: JE
authors.lastname: Obradovich
authors.forename: A W
authors.initials: AW
authors.lastname: Bollen
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure / Q000662:veterinary*; D003399:Craniotomy / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D016586:Granular Cell Tumor / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D012640:Seizures / Q000473:pathology / Q000601:surgery / Q000662:veterinary