title: Thrombotic thrombocytopenic purpura and systemic lupus erythematosus.
abstract: Thrombotic thrombocytopenic purpura (TTP) is a rarely seen complicating systemic lupus erythematosus (SLE). The diagnosis of TTP in a setting of SLE is challenging since both share common features including thrombotic microangiopathy. We report two cases of SLE with TTP one with a good response when cyclophosphamide was given early with plasmapheresis and steroids; the other with a poor outcome in a patient given cyclophosphamide late in the course of the disease.
authors.affiliation: Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA. vaidyaswatis@uams.edu
authors.forename: S
authors.initials: S
authors.lastname: Vaidya
authors.forename: S
authors.initials: S
authors.lastname: Abul-ezz
authors.forename: E
authors.initials: E
authors.lastname: Lipsmeyer
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000494:pharmacology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D011697:Purpura, Thrombotic Thrombocytopenic / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide