Brain development: integrins and the Reelin pathway.
Integrins link the extracellular matrix to the intracellular environment. They have been implicated in the Reelin pathway in cortical development. But new genetic studies have revealed that, while beta(1) integrin plays a role in formation of the basement membrane, it is not essential for neuronal migration.
Magdaleno
S M
SM
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. Susan.Magdaleno@stjude.org
Curran
T
T
D000818:Animals; D001921:Brain / Q000254:growth & development*; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D016023:Integrins / Q000502:physiology*; D051379:Mice; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D012697:Serine Endopeptidases
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D016023:Integrins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases