Production of prostaglandins and leukotrienes by pathogenic fungi.
These studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and systemic) have the ability to produce eicosanoids both from simple metabolites and from arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids represent a potential class of novel virulence factors.
Noverr
Mairi C
MC
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0642, USA.
Toews
Galen B
GB
Huffnagle
Gary B
GB
D003545:Cysteine / Q000096:biosynthesis*; D015237:Dinoprost / Q000096:biosynthesis*; D015232:Dinoprostone / Q000096:biosynthesis*; D007975:Leukotriene B4 / Q000096:biosynthesis*; D015289:Leukotrienes / Q000096:biosynthesis*; D003904:Mitosporic Fungi / Q000254:growth & development / Q000378:metabolism*; D009090:Mucorales / Q000254:growth & development / Q000378:metabolism*; D015230:Prostaglandin D2 / Q000096:biosynthesis*
D015289:Leukotrienes; C112381:cysteinyl-leukotriene; D007975:Leukotriene B4; D015237:Dinoprost; D015232:Dinoprostone; D003545:Cysteine; D015230:Prostaglandin D2