title: Atypical anterior optic neuropathy caused by toxoplasmosis.
abstract: OBJECTIVE
  To report atypical anterior optic neuropathy due to toxoplasmosis.
  
  
  METHODS
  Interventional case report. A 33-year-old male presented with sudden painless loss of vision and floaters in the right eye. Examination demonstrated a best-corrected visual acuity of 20/200, optic nerve head edema, retinal hemorrhages, and vitreous opacities.
  
  
  RESULTS
  Nine days later, a granuloma at the optic nerve head was apparent, and the patient was treated with pyrimethamine, sulfadiazine, folinic acid, and prednisone. Six weeks after initiating therapy, best-corrected visual acuity had improved to 20/25.
  
  
  CONCLUSIONS
  Optic nerve involvement in toxoplasmosis is uncommon and, when it occurs, usually presents with a white inflammatory mass on the optic disk. The current case demonstrates the importance of including toxoplasmosis in the differential diagnosis of unilateral anterior optic neuropathy, even if a focal inflammatory mass is not apparent.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33101, USA.
authors.forename: Alice
authors.initials: A
authors.lastname: Song
authors.forename: Ingrid U
authors.initials: IU
authors.lastname: Scott
authors.forename: Janet L
authors.initials: JL
authors.lastname: Davis
authors.forename: Byron L
authors.initials: BL
authors.lastname: Lam
mesh_terms: D000328:Adult; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005128:Eye Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005451:Fluorescein Angiography; D006099:Granuloma / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D010211:Papilledema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012166:Retinal Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014126:Toxoplasmosis, Ocular / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014792:Visual Acuity; D014822:Vitreous Body / Q000473:pathology*
chemical_list: D000981:Antiprotozoal Agents