title: Prophylactic antipyretic treatment with acetaminophen in acute ischemic stroke: a pilot study.
abstract: Fever is associated with poor outcome in acute stroke. Forty-two consecutive, normothermic patients with acute ischemic stroke were, within 24 hours from symptom onset, randomized to either receive 4 g acetaminophen daily (n = 20) or matched placebo (n = 22). Fever of greater than 37.5 degrees C occurred in 36.4% of patients in the placebo group, compared with 5.0% in the acetaminophen group (Fisher's exact test, p = 0.014). Prophylactic antipyretic treatment with acetaminophen may be effective in the prevention of fever after acute ischemic stroke.
authors.affiliation: Neurologische Abteilung, Stroke Unit, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany. h.koennecke@keh-berlin.de
authors.forename: H C
authors.initials: HC
authors.lastname: Koennecke
authors.forename: S
authors.initials: S
authors.lastname: Leistner
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D020521:Stroke / Q000188:drug therapy*
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen