Fluoroquinolone resistance among clinical isolates of Streptococcus pneumoniae belonging to international multiresistant clones.
Twenty-nine fluoroquinolone (FQ)-resistant clinical isolates of Streptococcus pneumoniae from a collection of isolates from the Alexander Project (1992-1997) and a study from Northern Ireland were identified on the basis of ofloxacin MICs > or = 4 mg/L. DNA fingerprint analyses using BOX-fingerprinting and pulsed-field gel electrophoresis revealed serotype 9V and 23F high-level FQ-resistant strains indistinguishable from the pandemic Spain(23F)-1 and Spain(9V)-3 clones, the type strains of which are low-level resistant or susceptible to the fluoroquinolones.
McGee
Lesley
L
Pneumococcal Diseases Research Unit of the Medical Research Council, The South African Institute for Medical Research and the University of the Witwatersrand, Johannesburg, South Africa. lesmcgee@hotmail.com
Goldsmith
Colin E
CE
Klugman
Keith P
KP
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002999:Clone Cells / Q000187:drug effects; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D024841:Fluoroquinolones; D006801:Humans; D012703:Serotyping / Q000706:statistics & numerical data; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification
D000890:Anti-Infective Agents; D024841:Fluoroquinolones