title: Full stereochemical understanding in a new (2R,3R,4R)-4-hydroxyisoleucine synthesis.
abstract: We present the crystal and molecular structures of 2,3,6,7,8,8a-hexahydro-6,8-methano-7,7,8a-trimethyl-3-(1-methyl-2-oxopropylidene)-5H-1,4-benzoxazin-2-one, C16H21NO3, (III), and 2,3,6,7,8,8a-hexahydro-3-(2-hydroxy-1-methylpropyl)-6,8-methano-7,7,8a-trimethyl-5H-1,4-benzoxazin-2-one, C16H25NO3, (V). These compounds are two of the four key intermediates in our synthetic route to (2R,3R,4R)-4-hydroxyisoleucine. The two structures provide a full understanding of the stereochemistry in successive steps. This synthesis was based on a new optically pure chiral oxazinone auxiliary derived from (1R,2R,5R)-2-hydroxypinan-3-one.
authors.affiliation: Laboratoire des Aminoacides, Peptides et Protéines, Université Montpellier I et II, Faculté de Pharmacie, UMR CNRS 5810, 15 Avenue Charles Flahault, 34060 Montpellier CEDEX 2, France. rolland@colombes.pharma.univ-montp1.fr
authors.forename: M
authors.initials: M
authors.lastname: Rolland
authors.forename: T
authors.initials: T
authors.lastname: Kassem
authors.forename: V
authors.initials: V
authors.lastname: Rolland
authors.forename: J
authors.initials: J
authors.lastname: Martinez