title: Failure to maintain long-term adherence to highly active antiretroviral therapy: the role of lipodystrophy.
abstract: In a sample of 277 patients included in the French APROCO cohort study who were initially adherent at follow-up visit 4 months after initiation of a protease inhibitor-containing regimen, 76.4% self-reported at least one lipodystrophy-related symptom and 30.0% failed to maintain adherence behaviour 20 months after enrolment. After multiple adjustment for other related factors, such as younger age, alcohol consumption and poor housing conditions, the number of self-reported lipodystrophy symptoms was independently associated with adherence failure.
authors.affiliation: INSERM U379, Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Duran
authors.forename: M
authors.initials: M
authors.lastname: Savès
authors.forename: B
authors.initials: B
authors.lastname: Spire
authors.forename: V
authors.initials: V
authors.lastname: Cailleton
authors.forename: A
authors.initials: A
authors.lastname: Sobel
authors.forename: P
authors.initials: P
authors.lastname: Carrieri
authors.forename: D
authors.initials: D
authors.lastname: Salmon
authors.forename: J P
authors.initials: JP
authors.lastname: Moatti
authors.forename: C
authors.initials: C
authors.lastname: Leport
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008060:Lipodystrophy / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011795:Surveys and Questionnaires; D013997:Time Factors