title: Long-term results of en bloc transplantation of pediatric kidneys into adults using a vicryl mesh envelope technique.
abstract: En bloc transplantation of pediatric kidneys into adults is a suitable measure to help correct the shortage of available kidneys. This practice, however, is not widespread because of the high incidence of vascular complications. Our institution has previously described a vicryl mesh technique for en bloc kidneys, with an attempt to reduce the incidence of vascular complications. The purpose of this study was to evaluate the long-term results of recipients with en bloc kidneys stabilized with this technique. The charts of 644 adult renal transplants performed between July 1987 and July 1999 were reviewed. During this period, 14 adult patients have received 14 pairs of en bloc pediatric kidneys using the vicryl mesh technique. All patients received OKT3 as an induction immunosuppression with cyclosporine started 10-14 d after the transplant. The median donor age was 24 months (range 14-84 months), and the median recipient age was 49 yr (range 23-68 yr). The mean recipient weight was 79 kg (range 60-114 kg). The mean cold ischemia time was 14.2 hr. None of the patients developed vascular or urological complications. Delayed graft function and moderate acute rejection occurred in one patient each. At a mean follow-up of 51 months (range 7-96 months), all 14 patients maintained excellent renal function with a mean creatinine of 1.01 mg/dL. Renal measurements pre-operatively and at follow-up ultrasound examinations were available in 9 patients, and the mean length of the kidneys had grown approximately 5.0 cm. These data demonstrate that minimal vascular and immunological complication rates can be achieved with pediatric en bloc kidneys using the vicryl mesh envelope technique.
authors.affiliation: Kidney Pancreas Transplant Service, NHS Clarkson Hospital/University Hospital, University of Nebraska Medical Center, Omaha, NE 68198-2360, USA.
authors.forename: S
authors.initials: S
authors.lastname: Chinnakotla
authors.forename: J P
authors.initials: JP
authors.lastname: Leone
authors.forename: R J
authors.initials: RJ
authors.lastname: Taylor
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007223:Infant; D016030:Kidney Transplantation / Q000379:methods*; D008875:Middle Aged; D016853:Muromonab-CD3 / Q000008:administration & dosage; D011098:Polyglactin 910; D013526:Surgical Mesh
chemical_list: D007166:Immunosuppressive Agents; D016853:Muromonab-CD3; D011098:Polyglactin 910; D016572:Cyclosporine