The natural substrate for nitric oxide synthase activity.
There has been little evidence to indicate that arginine is the natural substrate for generating nitric oxide synthase (NOS) activity. It is now shown that carnosine, which is widely distributed in tissues, is likely to be the true substrate. In tissue sections it gives a stronger NOS reaction than does arginine.
Alaghband-Zadeh
J
J
Department of Clinical Chemistry, Imperial College School of Medicine, Charing Cross Campus, London, UK.
Mehdizadeh
S
S
Khan
N S
NS
O'Farrell
A
A
Bitensky
L
L
Chayen
J
J
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D002336:Carnosine / Q000378:metabolism*; D005260:Female; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000737:chemistry / Q000201:enzymology*; D009249:NADP / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013379:Substrate Specificity; D013997:Time Factors
D009249:NADP; D002336:Carnosine; D001120:Arginine; D019001:Nitric Oxide Synthase