[Chronic colonic pseudo-obstruction secondary to neuroleptics].
Colonic pseudo-obstruction is characterized by non-mechanical chronic colonic dilatation. It is an infrequent entity that can be provoked by multiple causes, among them pharmacological. We present the case of a 74-year-old female psychiatric patient who presented abdominal bloating, diarrhea, intense electrolytic alterations and marked radiographic colonic dilatation after treatment with a neuroleptic (zuclopenthixol decanoate). Organic obstruction and other causes were ruled out and the final diagnosis was chronic colonic pseudo-obstruction secondary to the use of neuroleptics. Cisapride (20 mg/8 h) produced a slight improvement in symptoms but colonic dilatation was permanent.
Benlloch
S
S
Servicio de Medicina Digestiva, Hospital Universitario La Fe, Valencia, Spain.
Pérez-Aguilar
F
F
Ponce
J
J
Berenguer
J
J
D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003006:Clopenthixol / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003112:Colonic Pseudo-Obstruction / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans
D014150:Antipsychotic Agents; C029674:clopenthixol decanoate; D003006:Clopenthixol