Portal hypertension due to intrahepatic obstruction in non-Hodgkin's lymphoma.
Portal hypertension is rare in the setting of non-Hodgkin's lymphoma. We report here the case of a 73-year-old man presenting with diffuse high-grade B-cell lymphoma affecting predominantly the liver with large space occupying lesions. Histological examination of liver specimens showed abnormal large lymphoid cells whereas adjacent non-tumoural liver was normal. Portal hypertension was documented by upper gastrointestinal endoscopy that showed grade II oesophageal varices and measurement of portal pressures via transjugular approach showing increased hepatic venous pressure gradient (24 mmHg). We assume that portal hypertension was mainly related to these space occupying lesions.
Bachmeyer
C
C
Département de Médecine Interne, Hôpital Laënnec, Creil, France.
Harry
G
G
Cazier
A
A
Bonnard
P
P
Cadranel
J F
JF
D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis* / Q000209:etiology*; D008099:Liver / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008297:Male