Modelling of chemotherapy: the effective dose approach.
We sketch the development of the effective dose approach which provides a theoretical framework to interpret chemotherapy outcome data. Building on the generalised Skipper model of chemotherapy, a meta-regression method is derived to jointly analyse all chemotherapy comparing randomised clinical trials in a given malignancy in order to explore the slope of the effective dose/outcome relationship and the relative potency of cytostatic drugs. The model is applied to explain why treatment differences in aggressive NHL appear to differ by risk groups in aggressive NHL. A respective meta-subgroup analysis to confirm this interaction hypothesis is proposed.
Hasenclever
D
D
University of Leipzig, IMISE, Germany. Hasenclever@IMISE.uni-Leipzig.de
Brosteanu
O
O
Gerike
T
T
Loeffler
M
M
D000465:Algorithms; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D002455:Cell Division; D015986:Confounding Factors, Epidemiologic; D004305:Dose-Response Relationship, Drug; D019317:Evidence-Based Medicine; D006801:Humans; D016014:Linear Models; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D008962:Models, Theoretical; D016032:Randomized Controlled Trials as Topic; D012044:Regression Analysis; D012306:Risk; D013997:Time Factors; D016896:Treatment Outcome
D000970:Antineoplastic Agents