title: Characterization of melt-derived 45S5 and sol-gel-derived 58S bioactive glasses.
abstract: The ability of bioactive glasses to form a bond to living bone and also to stimulate bone-cell proliferation depends on the chemical composition and on the surface texture of the glasses. In this work, the differences in physical properties between the melt-derived 45S5 and sol-gel-derived 58S Bioglass powders of various particle-size ranges were studied. The powders were characterized for particle-size distribution by laser spectrometry, for specific surface area and porosity by nitrogen sorption analysis, and for morphological features by scanning electron microscopy. Melt-derived 45S5 powders exhibited a low-porosity texture with surface area in the range 0.15-2.7 m(2)/g. In contrast, the sol-gel-derived powders exhibited a highly mesoporous texture, with surface area in the range of 126.5-164.7 m(2)/g and a large fraction of 6-9 nm pore sizes. These differences in texture, as well as variations in chemical composition, account for significant changes in the resorption and in vivo responses.
authors.affiliation: Department of Materials, Centre for Tissue Regeneration and Repair, Imperial College of Science, Technology and Medicine London SW7 2BP, United Kingdom. pilarsi@net.ipen.br
authors.forename: P
authors.initials: P
authors.lastname: Sepulveda
authors.forename: J R
authors.initials: JR
authors.lastname: Jones
authors.forename: L L
authors.initials: LL
authors.lastname: Hench
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D002516:Ceramics; D005782:Gels; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009584:Nitrogen / Q000032:analysis; D010316:Particle Size; D016062:Porosity; D011208:Powders; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D005782:Gels; D011208:Powders; C425330:bioactive glass 45S5; C448994:bioactive glass 58S; D009584:Nitrogen