title: Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides.
abstract: The structural modification of the benzylic ether region of oxime 1 has resulted in the identification of several novel aryl amides as selective or dual NK(1)/NK(2) antagonists.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ 07033-1300, USA. neng-yang.shih@spcorp.com
authors.forename: Neng Yang
authors.initials: NY
authors.lastname: Shih
authors.forename: Margaret
authors.initials: M
authors.lastname: Albanese
authors.forename: John C
authors.initials: JC
authors.lastname: Anthes
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Carruthers
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Grice
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
authors.forename: Pietro
authors.initials: P
authors.lastname: Mangiaracina
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Reichard
authors.forename: John
authors.initials: J
authors.lastname: Schwerdt
authors.forename: Vera
authors.initials: V
authors.lastname: Seidl
authors.forename: Shing-Chung
authors.initials: SC
authors.lastname: Wong
authors.forename: John J
authors.initials: JJ
authors.lastname: Piwinski
mesh_terms: D064729:Neurokinin-1 Receptor Antagonists; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D064729:Neurokinin-1 Receptor Antagonists; D010091:Oximes; D018041:Receptors, Neurokinin-2