Report of a patient with a high level of parathyroid hormone-related peptide associated with malignant lymphoma involving multiple bony lesions.
Hypercalcemia in malignant lymphoma is not common. Our case of malignant lymphoma with multiple bony lesions showed hypercalcemia (13 mg/dl) at the time of bone marrow relapse. The serum level of parathyroid hormone-related peptide increased to 142 pmol/l, which may be secreted by malignant lymphoma cells. The course of the patient was aggressive and she died from bone marrow relapse after 6 months of treatment including high-dose methotrexate, which caused acute nonoliguric renal failure. At autopsy there was extensive calcium deposition in the lungs, kidneys and pancreas and prominent tubular damage of kidneys.
Kinugawa
Naoko
N
Section of Hematology/Oncology, Chiba Children's Hospital, Chiba City, Japan. QZD01355@nifty.ne.jp
Okimoto
Yuri
Y
Teraoka
Naoko
N
Sakao
Eiko
E
Horie
Hiroshi
H
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D006934:Hypercalcemia; D007668:Kidney / Q000473:pathology*; D008727:Methotrexate / Q000627:therapeutic use; D044162:Parathyroid Hormone-Related Protein; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy / Q000473:pathology*; D011506:Proteins / Q000378:metabolism*
D000964:Antimetabolites, Antineoplastic; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D008727:Methotrexate