title: MR imaging-histopathologic correlation of radiofrequency thermal ablation lesion in a rabbit liver model: observation during acute and chronic stages.
abstract: OBJECTIVE
  To determine the ability of MR imaging to detect the pathological changes occurring in radiofrequency (RF) thermal lesions and to assess its accuracy in revealing the extent of tissue necrosis.
  
  
  METHODS
  Using an RF electrode, thermal lesions were created in the livers of 18 rabbits. The procedure involved three phases. In the acute phase, six animals were killed the day after performing thermal ablation with RF energy, and two on day 3. In the subacute and chronic phases, eight rabbits underwent percutaneous hepatic RF ablation. After performing MR imaging, two animals were sacrificed at 1, 2, 4, and 7 weeks after the procedure, and MR-pathologic correlation was performed.
  
  
  RESULTS
  In the acute phase, the thermal ablation lesions appeared at gross examination as well-circumscribed, necrotic areas, representing early change in the coagulative necrosis seen at microscopic examination. They were hypointense on T2-weighted images, and hyperintense on T1-weighted images. Gadolinium-enhanced MR imaging showed that a thin hyperemic rim surrounded the central coagulative necrosis. In the subacute phase, ablated lesions also showed extensive coagulative necrosis and marked inflammation at microscopic examination. Beyond two weeks, the lesions showed gradual resorption of the necrotic area, with a peripheral fibrovascular rim. The size of lesions measured by MR imaging correlated well with the findings at gross pathologic examination.
  
  
  CONCLUSIONS
  MR imaging effectively demonstrates the histopathological tissue change occurring after thermal ablation, and accurately determines the extent of the target area.
authors.affiliation: Department of Diagnostic Radiology, Chonbuk National University Medical School, Chonju-shi, Chonbuk, Korea.
authors.forename: J D
authors.initials: JD
authors.lastname: Lee
authors.forename: J M
authors.initials: JM
authors.lastname: Lee
authors.forename: S W
authors.initials: SW
authors.lastname: Kim
authors.forename: C S
authors.initials: CS
authors.lastname: Kim
authors.forename: W S
authors.initials: WS
authors.lastname: Mun
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D008099:Liver / Q000473:pathology* / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D011817:Rabbits