title: Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats.
abstract: The protective effect of Bacopa monniera on morphine induced liver antioxidant levels was studied in rats. Oral administration of alcohol extracts of Bacopa monniera induced a significant hepatoprotective effect. In the morphine treated group, a significant increase of lipid peroxidation and a significant decrease in liver antioxidant enzyme levels were observed. Simultaneous administration of morphine and Bacopa extract prevented these alterations. The results of this study showed that Bacopa monniera alcohol extract exerted a hepatoprotective effect against morphine induced liver toxicity.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India.
authors.forename: T
authors.initials: T
authors.lastname: Sumathy
authors.forename: S
authors.initials: S
authors.lastname: Subramanian
authors.forename: S
authors.initials: S
authors.lastname: Govindasamy
authors.forename: K
authors.initials: K
authors.lastname: Balakrishna
authors.forename: G
authors.initials: G
authors.lastname: Veluchamy
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D008107:Liver Diseases / Q000201:enzymology / Q000517:prevention & control*; D019684:Magnoliopsida; D008297:Male; D009020:Morphine; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D009020:Morphine