title: Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.
abstract: Replacement of the 2-Adoc-D-alphaMeTrp residue in the non-selective CCK(1) receptor agonist PD 170292 by the Z-(2R,5R,11bS)-IBTM skeleton, able to fix a type II beta-turn-like conformation, led to a conformationally restricted dipeptoid analogue, namely 3a, which exhibited a notable increase in the CCK(1) selectivity and antagonist properties.
authors.affiliation: Instituto de Química Médica (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Martín-Martínez
authors.forename: Miriam
authors.initials: M
authors.lastname: Latorre
authors.forename: M Teresa
authors.initials: MT
authors.lastname: García-López
authors.forename: Edurne
authors.initials: E
authors.lastname: Cenarruzabeitia
authors.forename: Joaquín
authors.initials: J
authors.lastname: Del Río
authors.forename: Rosario
authors.initials: R
authors.lastname: González-Muñiz
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002956:Citrulline / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D018716:Molecular Mimicry; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000819:agonists*
chemical_list: C414945:PD 170292; D011949:Receptors, Cholecystokinin; D002956:Citrulline; D000218:Adamantane