title: Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo.
abstract: In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor beta (TGF-beta) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-beta.
authors.affiliation: Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. bryan.charleston@bbsrc.ac.uk
authors.forename: B
authors.initials: B
authors.lastname: Charleston
authors.forename: L S
authors.initials: LS
authors.lastname: Brackenbury
authors.forename: B V
authors.initials: BV
authors.lastname: Carr
authors.forename: M D
authors.initials: MD
authors.lastname: Fray
authors.forename: J C
authors.initials: JC
authors.lastname: Hope
authors.forename: C J
authors.initials: CJ
authors.lastname: Howard
authors.forename: W I
authors.initials: WI
authors.lastname: Morrison
mesh_terms: D000208:Acute Disease; D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology* / Q000473:pathology; D002417:Cattle; D002455:Cell Division; D001908:Diarrhea Viruses, Bovine Viral / Q000472:pathogenicity / Q000502:physiology*; D007108:Immune Tolerance / Q000276:immunology*; D007372:Interferons / Q000096:biosynthesis* / Q000276:immunology; D007700:Kinetics; D009163:Mycobacterium bovis / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000097:blood
chemical_list: D016212:Transforming Growth Factor beta; D007372:Interferons