Tachykinin receptors in the gut: physiological and pathological implications.
The tachykinins substance P and neurokinin A participate in the regulation of gastrointestinal motility, secretion, vascular permeability and pain sensitivity. Advances made during the past two years corroborate a causal involvement of tachykinins in inflammation-induced disturbances of gut function, such as dysmotility, secretory diarrhoea, oedema and hyperalgesia. It would therefore appear that tachykinin receptors, which in the digestive system are expressed in a cell-specific manner, represent attractive targets for novel therapeutics in gastroenterology.
Holzer
P
P
Department of Experimental and Clinical Pharmacology, University of Graz, Austria. peter.holzer@kfunigraz.ac.at
Holzer-Petsche
U
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D000818:Animals; D003109:Colonic Diseases, Functional / Q000188:drug therapy; D004064:Digestive System / Q000378:metabolism / Q000473:pathology; D004068:Digestive System Physiological Phenomena; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D005769:Gastrointestinal Motility; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D015288:Neurokinin A / Q000378:metabolism / Q000502:physiology; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D018041:Receptors, Neurokinin-2 / Q000378:metabolism; D018042:Receptors, Neurokinin-3 / Q000378:metabolism; D018039:Receptors, Tachykinin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism / Q000502:physiology
D018040:Receptors, Neurokinin-1; D018041:Receptors, Neurokinin-2; D018042:Receptors, Neurokinin-3; D018039:Receptors, Tachykinin; D013373:Substance P; D015288:Neurokinin A