title: Alterations in exhaled gas profile during allergen-induced asthmatic response.
abstract: The source of exhaled carbon monoxide (CO) and the relationship to airway inflammation are not clear. If CO is produced by the inflamed airway, we hypothesized that inflammation induced by allergen challenge would increase exhaled CO of atopic asthmatics. Eight atopic asthmatics underwent whole lung allergen challenge. CO, nitric oxide (NO), oxygen, and carbon dioxide (CO(2)) were measured simultaneously in exhaled breath which was collected into Mylar balloons before (baseline), immediately after, and at subsequent times after allergen. NO was higher in asthmatics than control subjects at baseline, increased further in seven of the eight asthmatics after allergen, and was inversely correlated to specific conductance. In contrast, exhaled CO of asthmatics was not higher than that of control individuals at baseline, decreased immediately after allergen, and returned to baseline levels during the late asthmatic response. Thus, allergen-induced airway inflammation did not lead to increased exhaled CO in asthma.
authors.affiliation: Departments of Pulmonary and Critical Care Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Khatri
authors.forename: M
authors.initials: M
authors.lastname: Ozkan
authors.forename: K
authors.initials: K
authors.lastname: McCarthy
authors.forename: D
authors.initials: D
authors.lastname: Laskowski
authors.forename: J
authors.initials: J
authors.lastname: Hammel
authors.forename: R A
authors.initials: RA
authors.lastname: Dweik
authors.forename: S C
authors.initials: SC
authors.lastname: Erzurum
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects*; D001249:Asthma / Q000175:diagnosis* / Q000276:immunology* / Q000503:physiopathology; D001944:Breath Tests / Q000295:instrumentation / Q000379:methods; D001985:Bronchial Provocation Tests / Q000009:adverse effects*; D002245:Carbon Dioxide / Q000032:analysis*; D002248:Carbon Monoxide / Q000032:analysis*; D016022:Case-Control Studies; D004804:Eosinophils; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007249:Inflammation; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis*; D010100:Oxygen / Q000032:analysis*; D010366:Peak Expiratory Flow Rate; D012882:Skin Tests; D014797:Vital Capacity
chemical_list: D000485:Allergens; D002245:Carbon Dioxide; D009569:Nitric Oxide; D002248:Carbon Monoxide; D010100:Oxygen