Neuronal signaling through alternative splicing: some exons CaRRE.
Alternative splicing represents a mechanism by which a single gene can be used to create proteins with different functions. Neurons use alternative splicing to produce channels with different sequences and biophysical or regulatory properties. O'Donovan and Darnell discuss a mechanism by which neurons can alter channel splicing in response to neuronal activity through a signal generated by calcium and calcium/calmodulin-dependent kinase activity.
O'Donovan
K J
KJ
Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. darnelr@rockefeller.edu
Darnell
R B
RB
D017398:Alternative Splicing / Q000502:physiology*; D000818:Animals; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics*; D005091:Exons / Q000235:genetics*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D012313:RNA / Q000235:genetics*; D020218:Response Elements / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics*
D012313:RNA; C517683:CAMK4 protein, human; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4; D017871:Calcium-Calmodulin-Dependent Protein Kinases