Protein phosphatase 1 and LTD: synapses are the architects of depression.
NMDAR-dependent long-term depression involves the activation of protein phosphatase 1 (PP1) and 2B (calcineurin) and the subsequent dephosphorylation of synaptic proteins. In this issue of Neuron, Morishita et al. (2001) provide evidence that precise targeting of PP1 to synaptic substrates is critical for the expression of LTD.
Isaac
J
J
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, BS8 1TD, Bristol, United Kingdom.
D000818:Animals; D017774:Long-Term Potentiation / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D054645:Protein Phosphatase 1; D013569:Synapses / Q000201:enzymology*
D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1