title: Short-term effect of the application of selective decontamination of the digestive tract on different body site reservoir ICU patients colonized by multi-resistant Acinetobacter baumannii.
abstract: The effect of a selective decontamination of the digestive tract (SDD) regimen including polymyxin and tobramycin on several body site reservoirs was compared between a test group and a control group in intensive care unit (ICU) patients with faecal multi-resistant Acinetobacter baumannii colonization. SDD significantly reduced faecal and pharyngeal carriage when compared with the control group at the end of ICU stay (48% versus 91%, P = 0.001, and 38.5% versus 78%, P = 0.01, respectively), but failed to reduce axillary colonization (75% versus 78%, P = 0.6). In addition, the isolation of A. baumannii from new clinical samples was lower in patients with SDD (45.5% versus 81%, P = 0.05). No resistance to polymyxin was observed. We conclude that the digestive tract reservoir of A. baumannii in ICU patients may be decreased by a SDD regimen.
authors.affiliation: Infectious Disease Service, Hospital de Bellvitge, C/Feixa Larga s/n, 08907 L'Hospitalet de Llobregat, University of Barcelona, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Agustí
authors.forename: M
authors.initials: M
authors.lastname: Pujol
authors.forename: M J
authors.initials: MJ
authors.lastname: Argerich
authors.forename: J
authors.initials: J
authors.lastname: Ayats
authors.forename: M
authors.initials: M
authors.lastname: Badía
authors.forename: M A
authors.initials: MA
authors.lastname: Domínguez
authors.forename: X
authors.initials: X
authors.lastname: Corbella
authors.forename: J
authors.initials: J
authors.lastname: Ariza
mesh_terms: D000150:Acinetobacter / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis / Q000379:methods* / Q000706:statistics & numerical data; D003091:Colistin / Q000008:administration & dosage; D004064:Digestive System / Q000187:drug effects* / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D014031:Tobramycin / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D014031:Tobramycin; D003091:Colistin