The metal site as a template for the metalloprotein structure formation.
Achieving a thorough explanation of the behavior of metal sites in the formation of native metalloprotein structures is an exciting challenge in the biochemistry of metallobiomacromolecules. This study presents a personal insight into the subject. It is proposed that a metal center and its exogenous ligand compose a template. A template may impose a clear stereochemical preference on the loose peptide chains, and organize them into natural stereospecificity via the metal-ligand interaction, a long-range and strong interaction. Therefore, the stable peptide conformation induced by the template effect surrounding a template polyhedron could be called a template-mediated structural motif (TMSM).
Liu
Changlin
C
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, PR China. L20919@public.wh.hb.cn
Xu
Huibi
H
D000818:Animals; D001665:Binding Sites; D006801:Humans; D008667:Metalloproteins / Q000737:chemistry*; D008670:Metals / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008958:Models, Molecular; D011487:Protein Conformation
D008667:Metalloproteins; D008670:Metals