title: IL-1 receptor type I gene expression in the amygdala of inflammatory susceptible Lewis and inflammatory resistant Fischer rats.
abstract: Lewis (LEW/N) and Fischer (F344/N) rats have different responses to inflammatory and behavioral stressors due to differences in hypothalamus-pituitary-adrenal (HPA) axis function. For example, LEW/N rats are more sensitive to restraint, inflammation and experimentally induced autoimmunity due to decreased HPA activity. The HPA axis response to peripheral inflammation is mediated, at least in part, by IL-1beta and its receptor, IL-1 type I (IL-1RI). Here, we studied the distribution of IL-1RI mRNA in the brains of LEW/N and F344/N rats, and demonstrated that IL-1RI mRNA expression has significantly increased in the basolateral nucleus (BLA) of the amygdala of LEW/N rats. These findings suggest that strain-specific HPA axis responses may be mediated by extrahypothalamic pathways.
authors.affiliation: UCLA Neuropsychiatric Institute and Brain Research Institute, 3357A Gonda Center, 695 Charles Young Dr., So., Los Angeles, CA 90095-1761, USA.
authors.forename: P
authors.initials: P
authors.lastname: Frost
authors.forename: R M
authors.initials: RM
authors.lastname: Barrientos
authors.forename: S
authors.initials: S
authors.lastname: Makino
authors.forename: M L
authors.initials: ML
authors.lastname: Wong
authors.forename: E M
authors.initials: EM
authors.lastname: Sternberg
mesh_terms: D000679:Amygdala / Q000276:immunology* / Q000503:physiopathology*; D000818:Animals; D004660:Encephalitis / Q000276:immunology* / Q000503:physiopathology*; D005260:Female; D015870:Gene Expression / Q000276:immunology; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology; D017403:In Situ Hybridization; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D053573:Receptors, Interleukin-1 Type I; D013045:Species Specificity
chemical_list: D012333:RNA, Messenger; D017472:Receptors, Interleukin-1; D053573:Receptors, Interleukin-1 Type I