title: Analysis of related factors in complications of stereotactic radiosurgery in intracranial tumors.
abstract: OBJECTIVE
  To investigate the related factors in complications of stereotactic radiosurgery for intracranial tumors.
  
  
  METHODS
  A retrospective review of 146 patients with intracranial tumors treated with stereotactic radiosurgery was conducted. Sixty-five patients received single-dose treatment and the rest received fractionated stereotactic radiosurgery. Ninety-five patients received conventional radiotherapy in the meantime.
  
  
  RESULTS
  Follow-up period was 18-54 months. Follow-up rate was 92.5% and 39 patients (26.7%) had different complications. The Cox statistics showed that target volume, target peripheral dose, target maximal dose, and ratio of maximal dose to peripheral dose are related to the complications. Conversely, neither type of tumor disease, gender, radiation schedule with or without conventional radiotherapy, target minimal dose, nor ratio of target peripheral isodose volume to target volume were found to be related to complications.
  
  
  CONCLUSIONS
  Target volume and dose are the major factors causing complications, and the optimization of the therapeutic planning can play a significant role in reducing them.
authors.affiliation: Department of Radiotherapy, Beijing Hospital, Beijing, China. liuyuanzhao@china.com
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Xiao
authors.forename: M
authors.initials: M
authors.lastname: Liu
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: He
authors.forename: B
authors.initials: B
authors.lastname: Hu
authors.forename: D
authors.initials: D
authors.lastname: Zu
mesh_terms: D001929:Brain Edema / Q000453:epidemiology* / Q000209:etiology; D001932:Brain Neoplasms / Q000556:secondary / Q000601:surgery*; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000601:surgery; D006261:Headache / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008297:Male; D008579:Meningioma / Q000601:surgery; D009325:Nausea / Q000453:epidemiology / Q000209:etiology; D009336:Necrosis; D009464:Neuroma, Acoustic / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D016016:Proportional Hazards Models; D011832:Radiation Injuries / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D016634:Radiosurgery / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000453:epidemiology / Q000209:etiology; D014839:Vomiting / Q000453:epidemiology / Q000209:etiology