Antimicrobial constituents from the stem bark of Feronia limonia.
The stem bark of Feronia limonia (Fam. Rutaceae) yielded (-)-(2S)-5,3'-dihydroxy-4'-methoxy-6",6"-dimethylchromeno-(7,8,2",3")-flavanone along with several known compounds including an alkaloid, five coumarins, a flavanone, a lignan, three sterols and a triterpene. The structures of these compounds were determined by spectroscopic methods, mainly 1D and 2D NMR. The antimicrobial screening of compounds by a microdilution technique resulted in MICs in the range 25-100 microg/ml. Other biological activities of the known compounds are also discussed.
Rahman
Md Mukhlesur
MM
Department of Pharmaceutical Sciences, University of Strathclyde, SIBS Building, 27 Taylor Street, G4 ONR, Glasgow, UK.
Gray
Alexander I
AI
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology
C450166:5,3'-dihydroxy-4'-methoxy-6'',6''-dimethylchromeno(7,8-2'',3'')flavanone; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D044950:Flavanones; D005419:Flavonoids; D013261:Sterols