title: Antimicrobial constituents from the stem bark of Feronia limonia.
abstract: The stem bark of Feronia limonia (Fam. Rutaceae) yielded (-)-(2S)-5,3'-dihydroxy-4'-methoxy-6",6"-dimethylchromeno-(7,8,2",3")-flavanone along with several known compounds including an alkaloid, five coumarins, a flavanone, a lignan, three sterols and a triterpene. The structures of these compounds were determined by spectroscopic methods, mainly 1D and 2D NMR. The antimicrobial screening of compounds by a microdilution technique resulted in MICs in the range 25-100 microg/ml. Other biological activities of the known compounds are also discussed.
authors.affiliation: Department of Pharmaceutical Sciences, University of Strathclyde, SIBS Building, 27 Taylor Street, G4 ONR, Glasgow, UK.
authors.forename: Md Mukhlesur
authors.initials: MM
authors.lastname: Rahman
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Gray
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C450166:5,3'-dihydroxy-4'-methoxy-6'',6''-dimethylchromeno(7,8-2'',3'')flavanone; D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D044950:Flavanones; D005419:Flavonoids; D013261:Sterols