A randomised trial of progesterone prophylaxis after midtrimester amniocentesis.
BACKGROUND
Midtrimester amniocentesis to investigate fetal karyotype carries a small risk of fetal loss.


OBJECTIVE
To test the hypothesis that progesterone prophylaxis may reduce this.


METHODS
A randomised controlled trial comparing a short prophylactic treatment with progesterone after amniocentesis with untreated controls.


RESULTS
There were no differences in frequency of miscarriage, preterm delivery or neonatal outcome.


CONCLUSIONS
Prophylactic progesterone treatment after amniocentesis does not improve obstetric outcome.
Corrado
Francesco
F
Institute of Gynecology, Policlinico Universitario, 98100, Messina, Italy. f.sco_corrado@tin.it
Dugo
Corrado
C
Cannata
Maria L
ML
Di Bartolo
Massimo
M
Scilipoti
Angela
A
Carlo Stella
Narcisio
N
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000517:prevention & control; D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000517:prevention & control; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology / Q000517:prevention & control; D005865:Gestational Age; D006801:Humans; D007752:Obstetric Labor, Premature / Q000453:epidemiology / Q000517:prevention & control; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000517:prevention & control*; D011374:Progesterone / Q000627:therapeutic use*
D011374:Progesterone