The STR-based genetic profile of the population from Corsica island (France).
Short tandem repeats (STR) at loci HumFES/FPS, HumVWA, HumCSF1PO, HumTH01, HumFXIIIA01, HumTPOX, HumCD4, D3S1358 are markers of choice for population genetics and validated systems for forensic use. In this report, we analysed their allele frequency distribution in a sample of native blood donors from the two departments of Corsica island (France). Deviations from the Hardy-Weinberg rule and heterozygosity values consistently suggested a spatial differentiation of allele and genotype frequencies across the island. Pairwise comparisons showed that Corsican gene pool presents a high level of heterogeneity between departments and substantially differs from that of neighbouring and historically-related populations. The results suggest the use of local databases to calculate a priori statistics in human identity testing.
Tofanelli
S
S
Department of Ethology, Ecology and Evolution, Anthropology Unit, University of Pisa, Via S. Maria 55, 56126 Pisa, Italy. sergtofa@discau.unipi.it
Taglioli
L
L
Varesi
L
L
Paoli
G
G
D000483:Alleles; D004247:DNA / Q000235:genetics*; D016208:Databases, Factual; D005602:France; D005828:Genetics, Population; D006801:Humans; D008390:Markov Chains; D020080:Tandem Repeat Sequences
D004247:DNA