title: Pegylated liposomal doxorubicin in combination with hyperthermia in the treatment of a case of advanced hepatocellular carcinoma.
abstract: BACKGROUND
  Currently, there is no standard treatment of inoperable advanced hepatocellular carcinoma.
  
  
  METHODS
  A patient with advanced hepatocellular carcinoma was treated with intravenous infusion of pegylated liposomal doxorubicin (PLD, Caelyx) in combination with ultrasound hyperthermia of the liver. Each cycle consisted of infusion of 60 mg of PLD followed by two fractions of hyperthermia 41 degrees C to 43 degrees C for 45 minutes 1 and 48 hours after infusion, respectively.
  
  
  RESULTS
  A substantial regression of the tumor was observed on computed tomography scans. No toxicity of combined treatment was noted.
  
  
  CONCLUSIONS
  This may be the first report of the combination of PLD and hyperthermia in the treatment of advanced hepatocellular carcinoma. Our observation suggests that the combination of PLD with hyperthermia is technically feasible, well tolerated, and could have synergistic potential.
authors.affiliation: Department of Oncology and Radiotherapy, Charles University Medical School & Teaching Hospital, Hradec Králové, Czech Republic. dvorakj@fnhd.cz
authors.forename: Josef
authors.initials: J
authors.lastname: Dvorák
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Zoul
authors.forename: Bohuslav
authors.initials: B
authors.lastname: Melichar
authors.forename: Pavel
authors.initials: P
authors.lastname: Jandík
authors.forename: Jindriska
authors.initials: J
authors.lastname: Mergancová
authors.forename: Ivana
authors.initials: I
authors.lastname: Motycková
authors.forename: Dagmar
authors.initials: D
authors.lastname: Kalousová
authors.forename: Jirí
authors.initials: J
authors.lastname: Petera
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000628:therapy*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008081:Liposomes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D004317:Doxorubicin