Influence of antioxidative vitamins A, C and E on lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters.
Persistent oxidative stress is thought to play an important role in carcinogenesis. Vitamins may influence oxygen radical metabolism and thus inhibit tumor growth. In the present trial the effects of Vitamins (Vit.) A, C and E on neoplastic growth and lipid peroxidation in pancreatic tissue were evaluated on chemically-induced pancreatic adenocarcinoma in the Syrian hamster. The incidence of pancreatic cancer was decreased by Vit. A (64.3%) and Vit. C (71.4%) as compared to the control group (100%, P<0.05). All vitamins increased the activity of superoxidedismutase (SOD) in pancreatic carcinomas. Accumulation of vitamins in tumor cells seems to be responsible for high levels of SOD and consecutive intracellular increase of hydrogen peroxide levels. Since this effect is selectively toxic for tumor cells it might be one of the mechanisms decreasing the incidence of pancreatic cancer in our trial.
Wenger
F A
FA
Department of General Visceral, Vascualr and Thoracic Surgery, Charité Campus Mitte, Humboldt-University of Berlin, Germany. charipanc@aol.com
Kilian
M
M
Ridders
J
J
Stahlknecht
P
P
Schimke
I
I
Guski
H
H
Jacobi
C A
CA
Müller
J M
JM
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D021441:Carcinoma, Pancreatic Ductal / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D006224:Cricetinae; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008647:Mesocricetus; D009602:Nitrosamines; D018384:Oxidative Stress / Q000187:drug effects; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014801:Vitamin A / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000494:pharmacology
D000970:Antineoplastic Agents; D000975:Antioxidants; D009602:Nitrosamines; D017392:Thiobarbituric Acid Reactive Substances; D014815:Vitamins; D014801:Vitamin A; C013622:nitrosobis(2-oxopropyl)amine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D024502:alpha-Tocopherol; D001205:Ascorbic Acid