Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion.
The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFNgamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation.
Arens
R
R
Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands.
Tesselaar
K
K
Baars
P A
PA
van Schijndel
G M
GM
Hendriks
J
J
Pals
S T
ST
Krimpenfort
P
P
Borst
J
J
van Oers
M H
MH
van Lier
R A
RA
D000818:Animals; D015703:Antigens, CD; D001402:B-Lymphocytes / Q000276:immunology*; D053282:CD27 Ligand; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000276:immunology*; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation / Q000276:immunology; D008212:Lymphocyte Depletion; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology*
D015703:Antigens, CD; D053282:CD27 Ligand; C505772:Cd70 protein, mouse; D008565:Membrane Proteins; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D007371:Interferon-gamma