MR cholangiography in the diagnosis of sclerosing cholangitis in Langerhans' cell histiocytosis.
Langerhans' cell histiocytosis (LCH) is a disorder of histiocytic proliferation that primarily affects infants. Imaging findings of a rare case of lung and liver involvement in an adult are presented. High-resolution computed tomography (HRCT) of the lungs showed confluent thin-walled cystic air spaces compatible with advanced LCH. Liver CT and MRI revealed unspecific signs of fatty infiltration. Irregular widening of peripheral bile ducts was displayed in breath-hold MR cholangiography. This pattern is considered characteristic for sclerosing cholangitis and should support the diagnosis of LCH in case of concomitant cystic pulmonary disease, even in adult patients.
König
C W
CW
Department of Diagnostic Radiology, University of Tübingen, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany. claudius.koenig@t-online.de
Pfannenberg
C
C
Trübenbach
J
J
Remy
C
C
Böhmer
G M
GM
Ruck
P
P
Claussen
C D
CD
D000368:Aged; D001652:Bile Ducts / Q000473:pathology; D002758:Cholangiography; D015209:Cholangitis, Sclerosing / Q000175:diagnosis*; D003287:Contrast Media; D019786:Gadolinium DTPA; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis*; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D019786:Gadolinium DTPA