title: Ovarian response during IVF-embryo transfer cycles after laparoscopic ovarian cystectomy for endometriotic cysts of >3 cm in diameter.
abstract: BACKGROUND
  Ovarian response during IVF cycles after laparoscopic ovarian cystectomy for endometriotic cysts >3 cm is controversial. A retrospective study was designed to study this problem.
  
  
  METHODS
  At laparoscopy, endometriomas >3 cm were treated by ovarian cystectomy, whilst adhesions and peritoneal endometriosis were treated using conventional techniques. Ovarian stimulation was achieved with clomiphene and gonadotrophins or with gonadotrophins after a desensitization with gonadotrophin-releasing hormone agonists. Three groups of patients were retrospectively selected from an IVF-embryo transfer database: patients who underwent laparoscopic ovarian cystectomy for an endometrioma >3 cm (Group A, n = 41), patients with endometriosis without ovarian endometrioma (Group B, n = 139) and patients with tubal infertility (Group C, n = 59).
  
  
  RESULTS
  The groups did not differ in age. In the first IVF cycle, the mean (+/- SD) numbers of oocytes and of embryos were 9.4 +/- 6.2 and 4.7 +/- 3.6 respectively in group A and 11.6 +/- 7.5 and 5.1 +/- 4.9 in group B (not significant). The results did not differ in cycles 2 and 3 or when compared according to age. No difference was found when comparing patients with endometriosis and patients with tubal infertility.
  
  
  CONCLUSIONS
  The number of oocytes and embryos obtained was not significantly decreased by laparoscopic cystectomy, suggesting that in experienced hands this procedure may be a valuable surgical tool for the treatment of large ovarian endometriomas. However, great care must be taken to avoid ovarian damage.
authors.affiliation: Department of Obstetrics, Gynaecology and Reproductive Medicine, CHU Bd. Leon Malfreyt 63058 Clermont Ferrand, Cedex 1 France. mcanis@chu-clermontferrand.fr
authors.forename: M
authors.initials: M
authors.lastname: Canis
authors.forename: J L
authors.initials: JL
authors.lastname: Pouly
authors.forename: S
authors.initials: S
authors.lastname: Tamburro
authors.forename: G
authors.initials: G
authors.lastname: Mage
authors.forename: A
authors.initials: A
authors.lastname: Wattiez
authors.forename: M A
authors.initials: MA
authors.lastname: Bruhat
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage; D004624:Embryo Transfer; D004622:Embryo, Mammalian; D004715:Endometriosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000008:administration & dosage; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007248:Infertility, Male / Q000628:therapy; D010535:Laparoscopy; D008297:Male; D009865:Oocytes; D010048:Ovarian Cysts / Q000503:physiopathology / Q000601:surgery*; D010049:Ovarian Diseases / Q000503:physiopathology / Q000601:surgery; D010053:Ovary / Q000503:physiopathology*; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies; D020858:Tissue and Organ Harvesting
chemical_list: D006062:Gonadotropins; D002996:Clomiphene