Cardiovascular effects of sildenafil citrate (Viagra): a naturalistic cross-over study.
In a cross-over study we investigated the effects of sildenafil (single doses of 25- or 50mg) on cardiovascular autonomic nervous system (ANS) function assessed by serial recordings of blood pressure, conventional 12-lead electrocardiograms and standardized, time-and frequency domain indices of heart rate variability (HRV) in 21 men with erectile dysfunction. More than half of these patients had multiple comorbidities. Sildenafil induced significant mean reductions from baseline in resting blood pressure, accompanied by a reflex increase in heart rate. There were no significant changes after administration of sildenafil in any other of the ANS function indices. These preliminary findings suggest that sildenafil does not significantly affect cardiac ANS function in patients with erectile dysfunction.
Agelink
M W
MW
Department of Biological Psychiatry and Neuroscience, Evangl. Clinics Gelsenkirchen, Ruhr-University of Bochum, Munckelstr. 27, D-45879 Gelsenkirchen, Germany. www.marcus.agelink@institute-of-biological-psychiatry.com
Schmitz
T
T
Rembrink
K
K
Beckerling
D
D
Mück-Weymann
M
M
Mercik
D
D
Brockmeyer
N H
NH
D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000187:drug effects; D017704:Baroreflex / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D018592:Cross-Over Studies; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage*; D010879:Piperazines / Q000008:administration & dosage*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate