title: Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma.
abstract: To investigate whether genetic differences in cytokine promoter polymorphisms effect various outcomes after exposure to Epstein-Barr virus (EBV) infection, 30 patients with EBV-positive gastric carcinoma (GC), 120 patients with EBV-negative GC, and 220 control subjects were enrolled. Promoter polymorphisms of tumor necrosis factor (TNF)-alpha at positions -238 and -308 and of interleukin (IL)-10 at position -1082 were determined. The frequency of the high-producer allele (-308A) in the TNF-alpha gene was significantly higher among EBV-positive GC patients compared with control subjects (23.3% vs. 12.0%, P<.05), whereas the frequency of the high-producer allele (-1082G) in the IL-10 gene was significantly higher among EBV-negative GC patients compared with control subjects (6.3% vs. 3.0%, P<.05). These data support the notion that genetic factors may modify the outcomes of infectious diseases through different TNF-alpha- or IL-10-producing capabilities.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
authors.forename: Ming-Shiang
authors.initials: MS
authors.lastname: Wu
authors.forename: Shih-Pei
authors.initials: SP
authors.lastname: Huang
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Chang
authors.forename: Chia-Tung
authors.initials: CT
authors.lastname: Shun
authors.forename: Ming-Chu
authors.initials: MC
authors.lastname: Chang
authors.forename: Ming-Tsan
authors.initials: MT
authors.lastname: Lin
authors.forename: Hsiu-Po
authors.initials: HP
authors.lastname: Wang
authors.forename: Jaw-Town
authors.initials: JT
authors.lastname: Lin
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000235:genetics* / Q000821:virology; D002681:China / Q000208:ethnology; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013274:Stomach Neoplasms / Q000150:complications / Q000235:genetics* / Q000821:virology; D013624:Taiwan; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10