Blood chemistry of rats pretreated with Mucuna pruriens seed aqueous extract MP101UJ after Echis carinatus venom challenge.
The effect of a lethal Echis carinatus venom on serum enzyme levels and blood plasma coagulation parameters in rats pretreated with Mucuna pruriens seed aqueous extract MP101UJ (21 mg/kg body wt) 24 h and 3 wk before i.p venom injection (0.50 mg/kg rat) and rats injected with venom alone (0.50 mg/kg body wt) was investigated. The enzyme levels and coagulation parameter levels were measured 4 h after venom administration. The results showed that the increased enzymes lactate dehydrogenase (LDH), glutamic pyruvic transaminase (SGPT), creatinine kinase (CK) and changed coagulation parameters D-Dimer and Quick levels due to the venom effect were inhibited by M. pruriens seed aqueous extract MP101UJ in pretreated rats. Rats pretreated with a single dose (21 mg/kg and multiple doses 21 mg/kg rat) of extract MP101UJ maintained the normal enzyme levels and showed an anticoagulant effect as evidenced by the high PTT level which was also observed in venom treated animals. D-Dimer and Quick values were normal. However, the extract MP101UJ appeared to significantly inhibit the lethal venom induced myotoxic, cytotoxic and coagulation activities in experimental animals.
Aguiyi
J C
JC
Department of Pharmacology and Clinical Pharmacy University of Jos, Jos, Nigeria. Aguiyi@unisi.it
Guerranti
R
R
Pagani
R
R
Marinello
E
E
D000818:Animals; D001769:Blood / Q000187:drug effects*; D001774:Blood Chemical Analysis; D001778:Blood Coagulation Disorders / Q000139:chemically induced / Q000517:prevention & control*; D003029:Coagulants / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008297:Male; D027805:Phaseolus; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D014757:Viper Venoms; D017819:Viperidae
D003029:Coagulants; D010936:Plant Extracts; D014757:Viper Venoms