Biochemistry and molecular cell biology of diabetic complications.
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.
Brownlee
M
M
Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA. brownlee@aecom.yu.edu
D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000209:etiology* / Q000473:pathology; D005544:Forecasting; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000473:pathology; D011493:Protein Kinase C / Q000378:metabolism
D017127:Glycation End Products, Advanced; D006595:Hexosamines; D011493:Protein Kinase C