Toxicity of trichloroethylene following inhalation and drinking contaminated water.
The neurobehavioural effects of trichloroethylene (TCE) were studied in rats following administration of the solvent orally (350, 700 and 1400 ppm in drinking water for 90 days) and through inhalation (376 ppm for 4 h a day, 5 days per week for 180 days). Various aspects of spontaneous locomotor activity were assessed at different periods after exposure through either of the routes. Oral exposure to TCE had no significant effect on spontaneous locomotor activity or cognitive ability, whereas inhalation to the solvent resulted in an increase in the distance travelled and horizontal activity counts at day 30 but a decrease at day 60 of exposure. The time spent in ambulatory and stereotypic movements as well as the number of stereotypic movements were enhanced significantly only at day 30. The resting time was decreased at day 30 but enhanced at day 60 of exposure. The learning ability was not affected significantly up to day 180. The results highlight the neurotoxic potential of inhalation exposure to TCE.
Waseem
M
M
Industrial Toxicology Research Centre, PB No. 80, M.G.Marg, Lucknow 226 001, India. intox@itrc.sirnetd.ernet.in
Ali
M
M
Dogra
S
S
Dutta
K K
KK
Kaw
J L
JL
D000284:Administration, Oral; D018685:Anesthetics, Inhalation / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal; D004305:Dose-Response Relationship, Drug; D019570:Inhalation Exposure; D007858:Learning; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*; D014241:Trichloroethylene / Q000633:toxicity*; D014867:Water / Q000737:chemistry; D014881:Water Supply
D018685:Anesthetics, Inhalation; D014867:Water; D014241:Trichloroethylene