title: Hyalinizing trabecular tumors of the thyroid: a variant of papillary carcinoma?
abstract: Ret proto-oncogene rearrangements are common in papillary thyroid carcinoma. The relationship of hyalinizing trabecular tumors (HTT) to papillary thyroid carcinoma (PTC) was analyzed in a recent report in which the presence of RET rearrangements was detected by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in several HTT. This commentary examines this report and related studies in the literature emphasizing the limitations of these approaches and the practical implications of these findings.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Ricardo V
authors.initials: RV
authors.lastname: Lloyd
mesh_terms: D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002648:Child; D004273:DNA, Neoplasm / Q000032:analysis; D029721:Drosophila Proteins; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D006818:Hyalin; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013964:Thyroid Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm; D029721:Drosophila Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila