title: Talairach-Tournoux brain atlas registration using a metalforming principle-based finite element method.
abstract: In this paper, a novel non-rigid registration method is proposed for registration of the Talairach-Tournoux brain atlas with MRI images and the Schaltenbrand-Wahren brain atlas. A metalforming principle-based finite element method with the large deformation problem is used to find the local deformation, in which finite element equations are governed by constraints in the form of displacements derived from the correspondence relationship between extracted feature points. Some detectable substructures, such as the cortical surface, ventricles and corpus callosum, are first extracted from MRI, forming feature points which are classified into different groups. The softassign method is used to establish the correspondence relationship between feature points within each group and to obtain the global transformation concurrently. The displacement constraints are then derived from the correspondence relationship. A metalforming principle-based finite element method with the large deformation problem is used in which finite element equations are reorganized and simplified by integrating the displacement constraints into the system equations. Our method not only matches the model to the data efficiently, but also decreases the degrees of freedom of the system and consequently reduces the computational cost. The method is illustrated by matching the Talairach-Tournoux brain atlas to MRI normal and pathological data and to the Schaltenbrand-Wahren brain atlas. We compare the results quantitatively between the force assignment-based method and the proposed method. The results show that the proposed method yields more accurate results in a fraction of the time taken by the previous method.
authors.affiliation: Laboratory of Neuro Imaging, Room 4238, UCLA, 710 Westwood, Los Angeles, CA 90095, USA. meihe@loni.ucla.edu
authors.forename: M
authors.initials: M
authors.lastname: Xu
authors.forename: W L
authors.initials: WL
authors.lastname: Nowinski
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology; D020342:Finite Element Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging