Detection of perfluorocarbons in blood by headspace solid-phase microextraction combined with gas chromatography/mass spectrometry.
A new method of detection of perfluorocarbon molecules (PFCs) in blood sample has been established. After an extraction and pre-concentration step performed by headspace solid-phase microextraction (HS-SPME), the PFCs are detected by gas chromatography-mass spectrometry (GC/MS) with an ion trap mass spectrometer in MS and MS/MS modes. The influence of different parameters on the SPME process is discussed. The limit of detection and the linearity of the procedure have been determined for two PFCs.
Mathurin
J C
JC
Laboratoire National de Dépistage du Dopage, Châtenay Malabry, France. jc.mathurin@wanadoo.fr
de Ceaurriz
J
J
Audran
M
M
Krafft
M P
MP
D005466:Fluorocarbons / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D011786:Quality Control; D012680:Sensitivity and Specificity; D013696:Temperature
D005466:Fluorocarbons