title: A neural network reflecting decisions about human faces.
abstract: Anatomic structures have been linked to the mnemonic component of working memory, but the neural network underlying associated decision processes remains elusive. Here we present an event-related functional magnetic resonance imaging study that measured activity during the decision period of a delayed face recognition task. A double dissociation of activity between anterior cingulate cortex (ACC), and a network including left fusiform face area (FFA) and left dorsolateral prefrontal cortex (DLPFC), reflected whether a probe face matched the remembered face at the time of decision. Greater activity in the left FFA and left DLPFC correlated with probe faces that matched the remembered face; in contrast, activity in ACC was greater when the probe face did not match the remembered face. These results support a model where frontal regions act in concert with stimulus-specific temporal structures to make recognition decisions about visual stimuli.
authors.affiliation: Helen Wills Neuroscience Institute, Department of Psychology, University of California, Berkeley, 3210 Tolman Hall, Berkeley, CA 94720, USA. druzgal@mail.med.upenn.edu
authors.forename: T J
authors.initials: TJ
authors.lastname: Druzgal
authors.forename: M
authors.initials: M
authors.lastname: D'Esposito
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D005145:Face; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology