title: Serum 17 beta-estradiol in newborn and neonatal hip instability.
abstract: This study evaluates the association between the level of 17 beta-estradiol in the umbilical cord blood and neonatal hip instability (NHI) in a population-based prospective case-control study comprising 2,185 consecutively newborns. beta-Estradiol levels were measured with a standard fluoroimmunoassay kit. Neonatal hip instability was determined by the anterior dynamic ultrasound method. An increased risk of NHI was found after breech malposition and in girls. Levels of beta-estradiol were higher in boys without NHI than in girls. A negative association between beta-estradiol level and parity was found. A significant association between beta-estradiol level and NHI was shown in boys with low serum concentrations. High levels of beta-estradiol tended to be associated with an increased risk of NHI in girls. An association was found between gender, parity, and beta-estradiol level in cord blood. No firm conclusion on the association between NHI and beta-estradiol level can be made; the possible association may be gender-dependent.
authors.affiliation: Department of Pediatrics, Blekingesjukhuset, Barn-och Ungdomskliniken, 371 85 Karlskrona, Denmark. john.andersson@ltblekinge.se
authors.forename: John E
authors.initials: JE
authors.lastname: Andersson
authors.forename: Ida
authors.initials: I
authors.lastname: Vogel
authors.forename: Niels
authors.initials: N
authors.lastname: Uldbjerg
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016001:Confidence Intervals; D004958:Estradiol / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006618:Hip Dislocation, Congenital / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D007593:Joint Instability / Q000097:blood* / Q000000981:diagnostic imaging; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011159:Population Surveillance; D011446:Prospective Studies; D012016:Reference Values; D012680:Sensitivity and Specificity; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D004958:Estradiol