Salmonella entry into host cells: the work in concert of type III secreted effector proteins.
Upon contact with intestinal epithelial cells, Salmonella enterica serovar spp. inject a set of bacterial proteins into host cells via the bacterial SPI-1 type III secretion system. SopE, SopE2 and SopB, activate CDC42 and Rac to initiate actin cytoskeleton rearrangements. SipA and SipC, two Salmonella actin-binding proteins, directly modulate host actin dynamics to facilitate bacterial uptake. SptP promotes the recovery of the actin cytoskeleton rearrangements by antagonizing CDC42 and Rac. Therefore, Salmonella-induced reversible actin cytoskeleton rearrangements are the result of two coordinated steps: (i) stimulation of host signal transduction to indirectly promote actin rearrangements and (ii) direct modulation of actin dynamics.
Zhou
D
D
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. zhoud@purdue.edu
Galán
J
J
D000199:Actins / Q000378:metabolism; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002417:Cattle; D003599:Cytoskeleton / Q000378:metabolism / Q000382:microbiology; D015964:Gene Expression Regulation, Bacterial; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D012480:Salmonella Infections / Q000382:microbiology*; D019779:Salmonella enterica / Q000472:pathogenicity*; D015398:Signal Transduction
D000199:Actins; D001426:Bacterial Proteins