title: Comparison of periovulatory and early pregnancy blood levels of oxytocinase (CAP1) and isooxytocinase (CAP2).
abstract: The previous studies on oxytocinase concentrated on its practical usability in monitoring advanced pregnancies, both normal and abnormal. However in early pregnancy the enzymatic values are within the norm for non-pregnant women and because of that they were not interesting for medicine, which makes use only of enzymatic values beyond the range of the norm. The aim of our study was to compare serum levels of oxytocinase (CAP1) and isooxytocinase (CAP2) in the first trimester of pregnancy between women who had miscarriage and those who delivered healthy babies. The study involved 234 pregnant women after infertility treatment. Serum oxytocinase and isosoxytocinase levels were evaluated in 157 women who delivered and in 77 women who had spontaneous miscarriage. Oxytocinase was assessed by means of H. Tuppy and H. Nesvadbas method modified by R. Klimek. For the first time it has been shown, that oxytocinase and isooxytocinase may play some role in proper development of early pregnancy, because the level of both isoenzymes at the beginning of pregnancy is statistically significantly higher in pregnancies ending in labor. Also about 3 weeks later and only in those successful pregnancies both enzymes undergo statistically significant further increase. Enzymatic changes correspond to hCG measurements.
authors.affiliation: Chair and Department of Endocrinology and Fertility, Jagiellonian University, Kopernika 23, Cracow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Dziechciowski
authors.forename: R
authors.initials: R
authors.lastname: Klimek
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood; D010122:Cystinyl Aminopeptidase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D010060:Ovulation / Q000097:blood*; D011247:Pregnancy / Q000097:blood*
chemical_list: D007527:Isoenzymes; D010122:Cystinyl Aminopeptidase