title: Assessment of a single-acquisition imaging sequence for oxygen-sensitive (3)He-MRI.
abstract: MRI of the lungs using hyperpolarized helium-3 ((3)He) allows the determination of intrapulmonary oxygen partial pressures (p(O2)). The need to separate competing processes of signal loss has hitherto required two different imaging series during two different breathing maneuvers. In this work, a new imaging strategy to measure p(O2) by a single series of consecutive scans is presented. The feasibility of the method is demonstrated in three healthy human volunteers. Maps and histograms of intrapulmonary p(O2) are calculated. Changes in the oxygen concentration of the inhaled gas mixture are well reproduced in the histograms. Monte Carlo (MC) simulations of the temporal evolution of (3)He hyperpolarization within the lungs were performed to evaluate the accuracy of this measurement technique, and its limitations.
authors.affiliation: Department of Physics, Johannes Gutenberg University, Mainz, Germany.
authors.forename: A J
authors.initials: AJ
authors.lastname: Deninger
authors.forename: B
authors.initials: B
authors.lastname: Eberle
authors.forename: J
authors.initials: J
authors.lastname: Bermuth
authors.forename: B
authors.initials: B
authors.lastname: Escat
authors.forename: K
authors.initials: K
authors.lastname: Markstaller
authors.forename: J
authors.initials: J
authors.lastname: Schmiedeskamp
authors.forename: W G
authors.initials: WG
authors.lastname: Schreiber
authors.forename: R
authors.initials: R
authors.lastname: Surkau
authors.forename: E
authors.initials: E
authors.lastname: Otten
authors.forename: H-U
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D003198:Computer Simulation; D006371:Helium; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007554:Isotopes; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D009010:Monte Carlo Method; D010100:Oxygen; D010313:Partial Pressure; D012123:Pulmonary Ventilation / Q000502:physiology
chemical_list: D007554:Isotopes; D006371:Helium; D010100:Oxygen