title: Long-term remission in a patient with metastatic collecting duct carcinoma treated with taxol/carboplatin and surgery.
abstract: Collecting duct carcinoma of the kidney is a rare and aggressive neoplasm of the distal collecting tubules for which there is no established therapy. We describe a young woman with metastatic collecting duct carcinoma who responded to Taxol/carboplatin chemotherapy with an 80% reduction in her tumor burden, including complete regression of lymph node metastases and significant shrinkage of a renal mass. She was rendered free of disease through nephrectomy and has been without a recurrence for 20 months. This suggests that Taxol/carboplatin chemotherapy and surgery should be considered for the treatment of metastatic collecting duct carcinoma.
authors.affiliation: Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Gollob
authors.forename: M P
authors.initials: MP
authors.lastname: Upton
authors.forename: W C
authors.initials: WC
authors.lastname: DeWolf
authors.forename: M B
authors.initials: MB
authors.lastname: Atkins
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy* / Q000601:surgery; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000601:surgery; D007686:Kidney Tubules, Distal / Q000601:surgery; D018365:Neoplasm, Residual; D009392:Nephrectomy; D017239:Paclitaxel / Q000008:administration & dosage; D012074:Remission Induction
chemical_list: D016190:Carboplatin; D017239:Paclitaxel