title: Hydroxychloroquine ototoxicity in a child with idiopathic pulmonary haemosiderosis.
abstract: Hydroxychloroquine, a quinoline compound, rarely causes ototoxicity. According to the few reports in existence, hydroxychloroquine-induced ototoxicity occurred following prolonged therapy in adult patients with rheumatoid arthritis and lupus erythematosus. We report a case of unilateral sensorineural hearing loss in a 7-year-old girl with idiopathic pulmonary haemosiderosis, after 2 years of hydroxychloroquine treatment. Sensorineural hearing loss has previously been reported with hydroxychloroquine treatment, but this is the first report in a child and associated to idiopathic pulmonary haemosiderosis and has the characteristic of being unilateral.
authors.affiliation: Department of Otolaryngology, Hospital de Crianças Maria Pia, Rua da Boavista 827, 4050-111, Porto, Portugal. miguelbebiano@hotmail.com
authors.forename: Miguel B
authors.initials: MB
authors.lastname: Coutinho
authors.forename: Idalinda
authors.initials: I
authors.lastname: Duarte
mesh_terms: D000158:Acoustic Impedance Tests; D001299:Audiometry; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000175:diagnosis; D006486:Hemosiderosis / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000009:adverse effects*; D008171:Lung Diseases / Q000150:complications / Q000188:drug therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D006886:Hydroxychloroquine