title: A phospholipase C inhibitor, phenylmethylsulfonyl fluoride, ameliorates ischemic injury to brain mitochondria in rats.
abstract: OBJECTIVE
  To study the effect of phenylmethylsulfonyl fluoride (PMSF), a phospholipase C inhibitor, on ischemic injury to brain mitochondria in rats.
  
  
  METHODS
  The phospholipid level, membrane fluidity, and respiratory control ratio of brain mitochondria were measured. The effect of phenylmethylsulfonyl fluoride was tested.
  
  
  RESULTS
  The phospholipid level, membrane fluidity, and respiratory control ratio of brain mitochondria in ischemia group decreased but increased in the PMSF treatment group (P < 0.05).
  
  
  CONCLUSIONS
  PMSF ameliorated ischemic injury to brain mitochondria in rats.
authors.affiliation: Department of Neurobiology, Life Science School, University of Science and Technology of China, Hefei 230027, China. wqss@china.com
authors.forename: Q S
authors.initials: QS
authors.lastname: Wang
authors.forename: J N
authors.initials: JN
authors.lastname: Zhou
authors.forename: T L
authors.initials: TL
authors.lastname: Xu
authors.forename: L S
authors.initials: LS
authors.lastname: Li
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors*
chemical_list: D010743:Phospholipids; D010664:Phenylmethylsulfonyl Fluoride; D010738:Type C Phospholipases