Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors.
Myoseverin, a trisubstituted purine, inhibits microtubule assembly in vitro, interferes with normal mitotic spindle assembly, and arrests the cell cycle in mitosis in U937 cells. We synthesized a variety of myoseverin derivatives and screened them for inhibition of spindle assembly in Xenopus egg extracts and for microtubule disassembly in vitro. Selected compounds were tested against 60 cancer cell lines at the National Cancer Institute as possible anticancer drug candidates.
Chang
Y T
YT
Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA. yt.chang@nyu.edu
Wignall
S M
SM
Rosania
G R
GR
Gray
N S
NS
Hanson
S R
SR
Su
A I
AI
Merlie
J
J
Moon
H S
HS
Sangankar
S B
SB
Perez
O
O
Heald
R
R
Schultz
P G
PG
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001704:Biopolymers; D002455:Cell Division / Q000187:drug effects; D003864:Depression, Chemical; D005434:Flow Cytometry; D006801:Humans; D066298:In Vitro Techniques; D009865:Oocytes; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008941:Spindle Apparatus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014020:Tissue Extracts; D014404:Tubulin / Q000737:chemistry; D020298:U937 Cells; D014982:Xenopus laevis
D000970:Antineoplastic Agents; D001704:Biopolymers; D011687:Purines; D014020:Tissue Extracts; D014404:Tubulin; C407365:myoseverin