title: Seesaw nystagmus following whole brain irradiation and intrathecal methotrexate.
abstract: A patient developed pendular seesaw nystagmus after receiving radiation and intrathecal methotrexate treatment for central nervous system lymphoma. Nystagmus developed without evidence of a brainstem lesion on magnetic resonance imaging. This case expands the causes of seesaw nystagmus and lends further support to the notion that midbrain lesions are not a prerequisite for its development.
authors.affiliation: Department of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, PA 19141, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Epstein
authors.forename: M L
authors.initials: ML
authors.lastname: Moster
authors.forename: M
authors.initials: M
authors.lastname: Spiritos
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects* / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007278:Injections, Spinal; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000209:etiology*; D009897:Optic Chiasm / Q000187:drug effects / Q000528:radiation effects; D009900:Optic Nerve / Q000187:drug effects / Q000528:radiation effects; D011832:Radiation Injuries / Q000209:etiology*; D014794:Visual Fields
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate