title: Reappraisal of the clinical significance of CD7 expression in association with cytogenetics in de novo acute myeloid leukaemia.
abstract: Debate exists over whether CD7 expression indicates an unfavourable prognosis in de novo acute myeloid leukaemia (AML). Meanwhile, the type of cytogenetics is a strong prognostic factor in AML. We analysed 256 de novo adult AML cases and found that the proportion of CD7+ cases increased stepwise from the cases with favourable cytogenetics to the cases with intermediate and unfavourable cytogenetics (3 out of 69 cases, 51 out of 140 cases and 25 out of 47 cases respectively, P < 0.0001). CD7-positivity adversely affected the survival only in the cases with unfavourable cytogenetics (P < 0.03). We recommend that CD7 expression in AML be interpreted in association with the cytogenetics.
authors.affiliation: Division of Haematology, Department of Medicine, Nippon Medical School, Tokyo, Japan. ogata@nms.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Ogata
authors.forename: N
authors.initials: N
authors.lastname: Yokose
authors.forename: Y
authors.initials: Y
authors.lastname: Shioi
authors.forename: Y
authors.initials: Y
authors.lastname: Ishida
authors.forename: J
authors.initials: J
authors.lastname: Tomiyama
authors.forename: H
authors.initials: H
authors.lastname: Hamaguchi
authors.forename: F
authors.initials: F
authors.lastname: Yagasaki
authors.forename: M
authors.initials: M
authors.lastname: Bessyo
authors.forename: H
authors.initials: H
authors.lastname: Sakamaki
authors.forename: K
authors.initials: K
authors.lastname: Dan
authors.forename: S
authors.initials: S
authors.lastname: Kuriya
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D019011:Antigens, CD7 / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D014178:Translocation, Genetic
chemical_list: D019011:Antigens, CD7; D015415:Biomarkers