Effect of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemia induced by Triton WR 1339 (tyloxapol) in mice.
The effect of trans-dehydrocrotonin (t-DCTN) from Croton cajucara Benth. was investigated in mice on Triton WR 1339 (tyloxapol)-induced hypercholesterolaemia and hypertriglyceridaemia. Mice treated with single application of tyloxapol (400 mg/kg, i.p.) demonstrated significantly increased blood levels of total cholesterol and triglycerides at 24 h and 48 h after its injection, compared to normal controls. These increases were found to be markedly suppressed in animals treated orally with 25 and 50 mg/kg t-DCTN or 100 mg/kg gemfibrozil, an established antihypercholesterolaemic drug. These results suggest that t-DCTN may be a suitable candidate for combating pathologies associated with hyperlipaemia.
Silva
R M
RM
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Santos
F A
FA
Maciel
M A
MA
Pinto
A C
AC
Rao
V S
VS
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D045785:Diterpenes, Clerodane; D015248:Gemfibrozil / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000188:drug therapy*; D015228:Hypertriglyceridemia / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000494:pharmacology
D004224:Diterpenes; D045785:Diterpenes, Clerodane; D000960:Hypolipidemic Agents; D028321:Plant Preparations; C103060:dehydrocrotonin; D011092:Polyethylene Glycols; D002784:Cholesterol; D015248:Gemfibrozil; C016811:tyloxapol