title: Cell proliferation, survival, and death in the Drosophila eye.
abstract: The Drosophila retina has a precise repeating structure based on the unit eye, or ommatidium. This review summarizes studies of the cell proliferation and survival episodes that affect the number of cells available to make each ommatidium. Late in larval development, as differentiation and patterning begin, the retinal epithelium exhibits striking regulation of the cell cycle including a transient G1 arrest of all cells, followed by a "Second Mitotic Wave" cell cycle that is regulated at the G2/M transition by local intercellular signals. Reiterated episodes of cell death also contribute to precise regulation of retinal cell number. The EGF receptor homolog has multiple roles in retinal proliferation and survival.
authors.affiliation: Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. baker@aecom.yu.edu
authors.forename: N E
authors.initials: NE
authors.lastname: Baker
mesh_terms: D000818:Animals; D002453:Cell Cycle; D016923:Cell Death; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D005123:Eye / Q000196:embryology* / Q000254:growth & development; D016193:G1 Phase; D015870:Gene Expression; D009024:Morphogenesis; D012160:Retina / Q000254:growth & development*; D015398:Signal Transduction