title: Targeting selectins for the treatment of respiratory diseases.
abstract: Inhibition of selectin function is expected to aid in the management of diseases characterized by aberrant or chronic inflammation, as in asthma and chronic obstructive pulmonary disease (COPD). Selectin-mediated adhesion of leukocytes to the vascular endothelium is a critical early event in the initiation of the inflammatory response, making it a good target for therapeutic intervention. Many approaches to modulating selectin function have been explored, including competitive inhibition, altering cell-surface expression and inducing shedding/cleavage from the cell surface; however, clinical success has been elusive.
authors.affiliation: Departments of Biology, Ontogen Corporation, Carlsbad, CA 92009, USA. sue.romano@ontogen.com
authors.forename: S J
authors.initials: SJ
authors.lastname: Romano
authors.forename: D H
authors.initials: DH
authors.lastname: Slee
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D001713:Biphenyl Compounds / Q000627:therapeutic use; D002448:Cell Adhesion / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002986:Clinical Trials as Topic; D004730:Endothelium, Vascular / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism / Q000502:physiology; D008024:Ligands; D008168:Lung / Q000276:immunology / Q000378:metabolism; D008358:Mannose / Q000031:analogs & derivatives; D008362:Mannosides / Q000627:therapeutic use; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D009844:Oligosaccharides / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000378:metabolism; D019087:Selectins / Q000378:metabolism*; D000080506:Sialyl Lewis X Antigen
chemical_list: D018927:Anti-Asthmatic Agents; D001713:Biphenyl Compounds; D008024:Ligands; D008362:Mannosides; D008562:Membrane Glycoproteins; D009844:Oligosaccharides; D019087:Selectins; D000080506:Sialyl Lewis X Antigen; C108700:bimosiamose disodium; D008358:Mannose