Tumour regression following stem cell infusion from daughter to microchimeric mother.
Fetal cells are known to persist in mothers for many years. We report a patient with poorly differentiated epithelial thymic carcinoma who had a large anterior mediastinal tumour, pericardial mass, left upper and right middle lobe tumour masses, and right liver mass. She received a single infusion of 10(10) stem cells from her 32-year-old daughter. Before the transfusion, she had had persistent chimeric cells from her daughter. The tumour regressed after stem cell infusion and has remained in regression for over 1 year. The daughter's cells were present at 330 days post infusion.
Tokita
K
K
Cancer Center of Irvine, CA, 92618, USA. medicimed@hotmail.com
Terasaki
P
P
Maruya
E
E
Saji
H
H
D000328:Adult; D002277:Carcinoma / Q000209:etiology / Q000628:therapy*; D002678:Chimera; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000628:therapy*; D008479:Mediastinal Neoplasms / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D013953:Thymus Neoplasms / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome