title: Scalloped and strawberry notch are target genes of Notch signaling in the context of wing margin formation in Drosophila.
abstract: The Notch pathway regulates the differentiation of many cell types throughout development of higher metazoa. Different cellular responses are elicited through specific activation of distinct Notch target genes. In the Drosophila wing, for example, the cut gene is activated by Notch signaling along the dorso-ventral boundary but, as we show here, not in other cell types. We identify additional regulatory components, scalloped and strawberry notch, that are targets of the Notch pathway specifically within the wing anlagen. As suggested by physical interactions, these proteins could be co-factors of the cut trans-regulator Vestigial. Additional regulatory input comes from the Wingless pathway. Our data support a model, whereby context specific involvement of distinct co-regulators modulates Notch target gene activation.
authors.affiliation: Institut für Genetik (240), Universität Hohenheim, Garbenstrasse 30, 70599, Stuttgart, Germany.
authors.forename: A C
authors.initials: AC
authors.lastname: Nagel
authors.forename: I
authors.initials: I
authors.lastname: Wech
authors.forename: A
authors.initials: A
authors.lastname: Preiss
mesh_terms: D000483:Alleles; D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D051880:Receptors, Notch; D015398:Signal Transduction; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D020798:Two-Hybrid System Techniques; D014921:Wings, Animal / Q000196:embryology*; D051155:Wnt1 Protein
chemical_list: D029721:Drosophila Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D051880:Receptors, Notch; D014157:Transcription Factors; D051155:Wnt1 Protein; C087984:sd protein, Drosophila; C106204:sno protein, Drosophila; C074622:wg protein, Drosophila