Calcium/calmodulin: a synaptic antidepressant?
Synaptic depression contributes to short-term changes in synaptic efficacy during sustained activity. Sakaba and Neher (2001) have characterized two kinetically distinct pools of releasable vesicles whose depletion underlies depression at a CNS synapse. Calcium/calmodulin dramatically accelerates replenishment of one of these pools--and hence recovery from depression.
Matthews
G
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Department of Neurobiology and Behavior, State University of New York, Stony Brook, NY 11794, USA.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
D002147:Calmodulin; D002118:Calcium