High-throughput organic synthesis of peptide mimetics.
This article is a subjective review of the literature from 1999 to March 2001. It seeks to highlight current progress in the high-throughput synthesis of peptide mimetics. The review is loosely classified into sections based on the type of secondary structural feature which is being mimicked (reverse turn, beta-strand, peptide surrogates) or a common motif. The examples chosen have demonstrated the ability to produce a large number of compounds rapidly or, in our opinion, the method could produce large numbers of compounds if desired.
Golebiowski
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Procter & Gamble Pharmaceuticals, Combinatorial Chemistry Section, Mason, OH 45040-8006, USA. golebiowskia@pg.com
Klopfenstein
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SR
Portlock
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D000818:Animals; D015195:Drug Design; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis* / Q000627:therapeutic use; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000627:therapeutic use
D010455:Peptides; D011480:Protease Inhibitors