title: Post-transfusion hepatitis C seroprevalence in Tanzanian children.
abstract: In Tanzania, children with malaria-associated anaemia are frequently given blood transfusions, and donor blood is not screened for hepatitis C virus (HCV) infection. To determine the seroprevalence of HCV infection in Tanzanian children previously transfused with blood, 184 children (92 transfused, 92 not transfused) aged between 15 and 59 months matched for age and sex were screened for HCV antibodies by the particle agglutination test using Serodia anti-HCV (Fujirebio Inc., Japan). The overall prevalence of HCV infection was 7.1% (13/184). HCV seropositivity was 5.4% (5/92) among children with a history of blood transfusion and 8.6% (8/92) among the non-transfused. There was no significant difference in the prevalence of HCV infection between transfused and non-transfused children. None of the factors investigated, such as gender, the nutrition and HIV serostatus of the children and the marital and education status of their mothers, was associated with HCV seropositivity. Further studies are recommended to identify the factors associated with HCV infection in Tanzanian children.
authors.affiliation: Departments of Paediatrics and Child Health, Muhimbili University College of Health Sciences, PO Box 65001, Dar es Salaam, Tanzania. jkitundu@muchs.ac.tz
authors.forename: J
authors.initials: J
authors.lastname: Kitundu
authors.forename: A
authors.initials: A
authors.lastname: Msengi
authors.forename: M
authors.initials: M
authors.lastname: Matee
authors.forename: M
authors.initials: M
authors.lastname: Fataki
authors.forename: T
authors.initials: T
authors.lastname: Kazimoto
authors.forename: R
authors.initials: R
authors.lastname: Mpembeni
authors.forename: E
authors.initials: E
authors.lastname: Mnubhi
authors.forename: F
authors.initials: F
authors.lastname: Kalokola
mesh_terms: D000372:Agglutination Tests; D016022:Case-Control Studies; D002675:Child, Preschool; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015483:HIV Antibodies / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology / Q000276:immunology / Q000635:transmission*; D018937:Hepatitis C Antibodies / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D016036:Seroepidemiologic Studies; D013636:Tanzania / Q000453:epidemiology; D065227:Transfusion Reaction
chemical_list: D015483:HIV Antibodies; D018937:Hepatitis C Antibodies