title: Antifungal sordarins. Synthesis and structure-activity relationships of 3'-O-substituted derivatives.
abstract: A number of novel 3'-O-acyl and alkyl sordarins were synthesised for structure-activity relationship studies. Many of these derivatives exhibit high activity against Candida albicans, Candida pseudotropicalis, Candida tropicalis and Cryptococcus neoformans.
authors.affiliation: GlaxoSmithKline, Research Department, Parque Tecnológico de Madrid, Severo Ochoa, 2. 28760 Tres Cantos, Madrid, Spain.
authors.forename: Enrique M
authors.initials: EM
authors.lastname: Arribas
authors.forename: Julia
authors.initials: J
authors.lastname: Castro
authors.forename: Ian R
authors.initials: IR
authors.lastname: Clemens
authors.forename: Juan C
authors.initials: JC
authors.lastname: Cuevas
authors.forename: Jesús
authors.initials: J
authors.lastname: Chicharro
authors.forename: Ma Teresa
authors.initials: MT
authors.lastname: Fraile
authors.forename: Silvestre
authors.initials: S
authors.lastname: García-Ochoa
authors.forename: Federico
authors.initials: F
authors.lastname: Gómez de las Heras
authors.forename: José R
authors.initials: JR
authors.lastname: Ruiz
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D007192:Indenes; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D007192:Indenes; C003329:sordarin