title: Combination therapy with indolylquinoline derivative and sodium antimony gluconate cures established visceral leishmaniasis in hamsters.
abstract: 2-(2"-Dichloroacetamidobenzyl)-3-(3'-indolylquinoline), designated indolylquinoline derivative A, reduced the splenic and the liver parasite burdens by >93.0% in Leishmania donovani-infected hamsters, whereas sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%. Complete clearance of parasitemia from the livers and spleens was noticed when infected animals received indolylquinoline derivative A plus SAG, suggesting that indolylquinoline derivative A has potential as a new agent for sole or conjunctive therapy for leishmaniasis.
authors.affiliation: Immunology Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata-700 032, India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Pal
authors.forename: Mousumi
authors.initials: M
authors.lastname: Raha
authors.forename: Anirban
authors.initials: A
authors.lastname: Basu
authors.forename: Keshab Chandra
authors.initials: KC
authors.lastname: Roy
authors.forename: Anasuya
authors.initials: A
authors.lastname: Gupta
authors.forename: Monidipa
authors.initials: M
authors.lastname: Ghosh
authors.forename: Niranjan Prasad
authors.initials: NP
authors.lastname: Sahu
authors.forename: Sukdeb
authors.initials: S
authors.lastname: Banerjee
authors.forename: Nirup Bikash
authors.initials: NB
authors.lastname: Mandal
authors.forename: Santu
authors.initials: S
authors.lastname: Bandyopadhyay
mesh_terms: D000818:Animals; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D006224:Cricetinae; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D007211:Indoles / Q000627:therapeutic use*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D011804:Quinolines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C443758:2-(2''-dichloroacetamidobenzyl)-3-(3'-indolylquinoline); D000981:Antiprotozoal Agents; D007211:Indoles; D011804:Quinolines; D000967:Antimony Sodium Gluconate