Serotonin and brain development: role in human developmental diseases.
Serotonin is known to play a role in brain development prior to the time it assumes its role as a neurotransmitter in the mature brain. Serotonin regulates both the development of serotonergic neurons (termed autoregulation of development) and the development of target tissues. In both cases, the astroglial-derived protein, S-100beta plays a role. Disruption of serotonergic development can leave permanent alterations in brain function and behavior. This may be the case in such human developmental illnesses as autism and Down Syndrome.
Whitaker-Azmitia
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PM
Program in Biopsychology, Department of Psychology, SUNY at Stony Brook, 11794-2500, USA. whitaker@psych1.psy.sunysb.edu
D000818:Animals; D001321:Autistic Disorder / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000002:abnormalities* / Q000254:growth & development / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics*; D004314:Down Syndrome / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009414:Nerve Growth Factors; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000235:genetics*; D012701:Serotonin / Q000378:metabolism*
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D012701:Serotonin