title: Ageing impairs insulin-mediated vasodilatation but not forearm glucose uptake.
abstract: BACKGROUND
  It is unclear if insulin-mediated vasodilatation is altered by ageing and if this affects insulin-mediated glucose uptake.
  
  
  METHODS
  A 2-h euglycaemic hyperinsulinaemic clamp (56 mU m(-2) min(-1)) was performed in 10 healthy, nonobese elderly men (70-75 years) and 13 young men (23-28 years). Forearm blood flow (FBF) was measured by venous occlusion plethysmography and forearm glucose uptake was calculated by arterial and venous serum glucose determinations in the forearm.
  
  
  RESULTS
  Insulin induced an increase in FBF in the younger men (from 3.9 +/- 1.1 SD to 5.9 +/- 2.2 mL min(-1) 100(-1)mL tissue, P < 0.001), but this insulin-mediated vasodilatation was completely blunted in the elderly subjects. Glucose extraction during the clamp was significantly higher in the elderly subjects (1.2 +/- 0.76 vs. 0.82 +/- 0.37 mmol L(-1) at 120 min, P < 0.01), resulting in a similar forearm glucose uptake in the two groups. On the other hand, whole-body glucose uptake was significantly decreased in the elderly subjects (5.3 +/- 1.8 vs. 8.0 +/- 1.1 mg kg(-1) min(-1), P < 0.001).
  
  
  CONCLUSIONS
  The present study showed that the ability of insulin to induce vasodilatation is blunted in the forearm in healthy, nonobese elderly subjects. However, the elderly compensate for this impairment with an increased glucose extraction from arterial blood to maintain an unaltered forearm glucose uptake.
authors.affiliation: Department of Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden. lars.lind@medsci.uu.se
authors.forename: L
authors.initials: L
authors.lastname: Lind
authors.forename: A
authors.initials: A
authors.lastname: Fugmann
authors.forename: J
authors.initials: J
authors.lastname: Millgård
authors.forename: C
authors.initials: C
authors.lastname: Berne
authors.forename: H
authors.initials: H
authors.lastname: Lithell
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood* / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism*; D005542:Forearm; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D014664:Vasodilation / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007328:Insulin