Is 4q13 a recurring breakpoint in solitary fibrous tumors?
Solitary fibrous tumor (SFT) is a mesenchymal neoplasm found predominantly in the subpleural region but also in many other body sites. We report a malignant solitary fibrous tumor of the peritoneum with a 47,XY,t(4;9)(q13;p23),+5 karyotype. The chromosome 4q13 breakpoint in the presented and previously published case of pleural solitary fibrous tumor with a 46,XY,t(4;15)(q13;q26) karyotype was further characterized by fluorescence in situ hybridization analysis and localized within the 5-cM interval that was flanked by regions specific to YAC clones 761A7 and 886C11. Chromosome translocations involving chromosome 4q13 may characterize a separate cytogenetic subgroup of SFT.
Debiec-Rychter
M
M
Center of Human Genetics, Katholieke Universiteit Leuven, 49, B-3000 Leuven, Herestraat, Belgium. maria.debiec-rychter@med.kuleuven.ac.be
de Wever
I
I
Hagemeijer
A
A
Sciot
R
R
D000368:Aged; D000369:Aged, 80 and over; D019457:Chromosome Breakage / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000235:genetics* / Q000473:pathology*; D014178:Translocation, Genetic / Q000235:genetics