Evaluation of mechanical arterial properties: clinical, experimental and therapeutic aspects.
Ageing and disease states associated with an increase in cardiovascular events alter the physical characteristics of blood vessel walls and impair the pulsatile function of arteries. An accumulating body of evidence indicates that impaired pulsatile function of arteries provides important prognostic and therapeutic information beyond that provided by traditional blood pressure measurements. A variety of techniques are currently employed to evaluate the mechanical properties of arteries. All techniques have theoretical, technical and practical limitations that impact on their widespread application in the clinical setting and use as measurement tools to improve cardiovascular risk stratification. A detailed discussion of these issues forms the basis of this review.
McVeigh
Gary E
GE
Department of Therapeutics and Pharmacology, Whitla Medical Building, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, U.K. g.mcveigh@qub.ac.uk
Hamilton
Paul K
PK
Morgan
David R
DR
D001158:Arteries / Q000033:anatomy & histology / Q000502:physiology*; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology*; D003935:Diagnostic Techniques, Cardiovascular; D005583:Fourier Analysis; D006801:Humans; D008954:Models, Biological; D012307:Risk Factors; D014655:Vascular Resistance / Q000502:physiology