Increase of tyrosine hydroxylase and dopamine transporter mRNA levels in ventral tegmental area of male mice under influence of repeated aggression experience.
Tyrosine hydroxylase (TH) and dopamine transporter (DAT) mRNA levels in the ventral tegmental area (VTA) of midbrain were measured by multiplex RT-PCR in male mice with repeated experience of social victories (winners) and social defeats (losers) in 10 daily agonistic confrontations. Two independent experiments revealed enhanced TH and DAT mRNA levels in VTA of the winners in comparison with the losers and controls (animals after 5 days of individual housing). A positive correlation between DAT and TH mRNA levels was shown.
Filipenko
M L
ML
Institute of Bioorganic Chemistry SD RAS, Pr. Lavrentieva, 8, 630090, Novosibirsk, Russia. max@niboch.nsc.ru
Alekseyenko
O V
OV
Beilina
A G
AG
Kamynina
T P
TP
Kudryavtseva
N N
NN
D000374:Aggression / Q000502:physiology*; D000818:Animals; D050483:Dopamine Plasma Membrane Transport Proteins; D015870:Gene Expression / Q000502:physiology; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000235:genetics*; D051379:Mice; D008808:Mice, Inbred CBA; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013315:Stress, Psychological / Q000503:physiopathology; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*; D017557:Ventral Tegmental Area / Q000502:physiology*
D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C493215:Slc6a3 protein, mouse; D014446:Tyrosine 3-Monooxygenase