title: Ischemic cardiovascular disease in persons with human immunodeficiency virus infection.
abstract: Persons with human immunodeficiency virus (HIV) infection might be at risk for ischemic cardiovascular disease (CVD). We reviewed the records of 16 HIV-infected persons with proven CVD (8 cases of angina and 8 cases of myocardial infarctions). This represents 1.7% of HIV-infected persons seen at our institution from 1 April 1999 through 25 April 2000. In comparison with 32 HIV-infected age- and sex-matched controls, case patients had more risk factors for CVD (median number of risk factors for CVD, 3 versus 1; P<.001), lower nadir CD4+ lymphocyte counts (median, 101 cells/mm3 versus 278 cells/mm3; P=.02), and a longer duration of prior exposure to nucleoside analogs (median, 190 weeks versus 130 weeks; P=.02). There was no difference in the duration of exposure to protease inhibitors. Ischemic CVD occurs in HIV-infected persons and appears to be most closely associated with traditional risk factors for coronary artery disease (for example, hypertension and hypercholesterolemia). Lower CD4+ lymphocyte counts and duration of HIV infection might also be risk factors or markers for the development of ischemic CVD.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0405 , USA.
authors.forename: Max H
authors.initials: MH
authors.lastname: David
authors.forename: Richard
authors.initials: R
authors.lastname: Hornung
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Fichtenbaum
mesh_terms: D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D017320:HIV Protease Inhibitors / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D017320:HIV Protease Inhibitors