Genetic targets for the treatment of pituitary adenomas: focus on the pituitary tumor transforming gene.
The pituitary tumor transforming gene (PTTG) has been identified as a key protein in mitotic regulation. The hypothesis that PTTG overexpression results in genetic instability has been strengthened by the recent observation of inappropriate and aneuploid cell division in cell lines expressing high levels of PTTG. PTTG transactivates the oncogene c-myc, which in turn may influence cell growth. A direct link between PTTG, basic fibroblast growth factor and angiogenesis has been demonstrated.
McCabe
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Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK. mccabcjz@bham.ac.uk
D000236:Adenoma / Q000235:genetics / Q000628:therapy*; D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division; D004268:DNA-Binding Proteins / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000235:genetics; D016259:Genes, myc; D015316:Genetic Therapy; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D048369:MAP Kinase Kinase 1; D008565:Membrane Proteins; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D010911:Pituitary Neoplasms / Q000235:genetics / Q000628:therapy*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D064249:Securin; D017385:Sequence Homology; D015533:Transcriptional Activation
D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C112633:PTTG1IP protein, human; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human; D016222:Fibroblast Growth Factor 2; D017346:Protein Serine-Threonine Kinases; D048369:MAP Kinase Kinase 1; C482125:MAP2K1 protein, human; D020929:Mitogen-Activated Protein Kinase Kinases