title: Traumatic rupture of the thoracic aorta: cohort study and systematic review.
abstract: OBJECTIVE
  Through a systematic review of the literature, we identified the optimal management of traumatic ruptures of the thoracic aorta (TRTA) and reported the results of a cohort of patients treated with the clamp-and-sew technique (CAS) at a tertiary trauma center.
  
  
  METHODS
  Studies were identified through Medline and the Cochrane library and from reference lists and papers from the authors' files. Studies with a single consistent protocol (CAS, Gott shunt [GS], left heart bypass [LHB], or partial cardiopulmonary bypass [PCPB]) that reported mortality and neurologic outcomes were included. Relevance, validity, and data extraction were performed in duplicate. A retrospective review of charts from June 1992 to August 2000 provided the database for our experience.
  
  
  RESULTS
  Twenty studies reporting on 618 patients were found to be relevant. Interobserver agreement for relevance and validity decisions was high. Mortality rates for repair with CAS, GS, LHB, and PCPB were 15%, 8%, 17%, and 10%, respectively, and for paraplegia they were 7%, 4%, 0%, and 2%, respectively. The difference in mortality rates was not statistically significant. CAS had a higher incidence of neurologic deficits than GS (odds ratio [OR], 1.8; 95% CI, 0.4-8), LHB (OR, 6.4; 95% CI, 0.8-50), and PCPB (OR, 3.4; 95% CI, 1-10). In our cohort of 25 patients, 21 underwent surgery with CAS. The median abbreviated injury severity score was 20 (range, 4-50). The mean aortic clamp time was 30 +/- 12 minutes. Aortic repair was achieved with graft interposition in 43% of patients, and simple suture was achieved in 57% of patients. Mortality (10%) and neurologic complication (paraplegia, 11%; paraparesis, 5%) rates were not statistically different from those reported in the literature.
  
  
  CONCLUSIONS
  CAS is associated with a similar mortality rate but a higher incidence of neurologic deficits than methods with distal aortic perfusion.
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Hamilton Health Sciences Corporation, General Campus, McMaster University, Ontario, Canada.
authors.forename: A S
authors.initials: AS
authors.lastname: Jahromi
authors.forename: K
authors.initials: K
authors.lastname: Kazemi
authors.forename: H A
authors.initials: HA
authors.lastname: Safar
authors.forename: B
authors.initials: B
authors.lastname: Doobay
authors.forename: C S
authors.initials: CS
authors.lastname: Cinà
mesh_terms: D015998:Abbreviated Injury Scale; D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D001013:Aorta, Thoracic / Q000293:injuries*; D001019:Aortic Rupture / Q000145:classification / Q000150:complications / Q000401:mortality / Q000601:surgery*; D002315:Cardiopulmonary Bypass / Q000379:methods; D003250:Constriction; D005260:Female; D005500:Follow-Up Studies; D018611:Heart Bypass, Left / Q000379:methods; D006489:Hemostatic Techniques / Q000009:adverse effects; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013536:Suture Techniques / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome