title: Antifungal principles from Piper fulvescens.
abstract: Activity-guided fractionation of the dichloromethane extract from leaves of Piper fulvescens, using an agar overlay bioautographic method, led to the isolation of three antifungal neolignans identified as conocarpan, eupomatenoid 5 and eupomatenoid 6. The minimal inhibitory concentration of these three neolignans against five fungi strains were determined. Conocarpan showed the widest activity, whereas eupomatenoid 6 was the most active against dermatophytes.
authors.forename: B
authors.initials: B
authors.lastname: Freixa
authors.forename: R
authors.initials: R
authors.lastname: Vila
authors.forename: E A
authors.initials: EA
authors.lastname: Ferro
authors.forename: T
authors.initials: T
authors.lastname: Adzet
authors.forename: S
authors.initials: S
authors.lastname: Cañigueral
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D010239:Paraguay; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D026321:Piperaceae; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D001572:Benzofurans; D005663:Furans; D010636:Phenols; D010936:Plant Extracts; C447284:conocarpan; C452812:eupomatenoid 6; C452811:eupomatenoid 5