The search for the ideal biocatalyst.
While the use of enzymes as biocatalysts to assist in the industrial manufacture of fine chemicals and pharmaceuticals has enormous potential, application is frequently limited by evolution-led catalyst traits. The advent of designer biocatalysts, produced by informed selection and mutation through recombinant DNA technology, enables production of process-compatible enzymes. However, to fully realize the potential of designer enzymes in industrial applications, it will be necessary to tailor catalyst properties so that they are optimal not only for a given reaction but also in the context of the industrial process in which the enzyme is applied.
Burton
Stephanie G
SG
Department of Chemical Engineering, University of Cape Town, Cape Town, South Africa.
Cowan
Don A
DA
Woodley
John M
JM
D000818:Animals; D001709:Biotechnology / Q000379:methods; D002384:Catalysis; D004247:DNA / Q000032:analysis; D004798:Enzymes / Q000096:biosynthesis* / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D011489:Protein Denaturation; D013045:Species Specificity; D013696:Temperature
D004798:Enzymes; D004247:DNA