title: Prognosis of giant cell tumor of bone. Histopathological analysis of 15 cases and review of the literature.
abstract: BACKGROUND
  The purpose of this study is the evaluation of certain markers determining the prognosis of giant cell tumor of bone.
  
  
  METHODS
  A clinicopathological analysis of 15 cases of giant cell tumor is presented.
  
  
  RESULTS
  Giant cell tumor of bone mainly affects women with an average age of 34 years and is located in the upper and distal ends of the long tubular bones (93.3%). 60% of the tumor biopsies was Grade I, 33.3 % Grade II and 6.7% Grade III. The recurrence rate was 33.3% and the malignant transformation was 13.3%.
  
  
  CONCLUSIONS
  Prognosis of giant cell tumor of bone is likely to be mistaken if it is based only on the histological picture. On the contrary, considering important parameters, such as tumor location, size and tumor aggressiveness, frequency of recurrences and type of surgical management, one may predict in most cases the clinical outcome of the neoplastic process.
authors.affiliation: Cytologic Laboratory of Marica Eliadi Hospital, Athens, Greece. anagn@panafonet.gr
authors.forename: S
authors.initials: S
authors.lastname: Boutou-Bredaki
authors.forename: P
authors.initials: P
authors.lastname: Agapios
authors.forename: G
authors.initials: G
authors.lastname: Papachristou
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D017678:Sex Distribution; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor