title: Effect of soy protein on endogenous hormones in postmenopausal women.
abstract: BACKGROUND
  The long-term clinical effects of soy protein containing various concentrations of isoflavones on endogenous hormones are unknown.
  
  
  OBJECTIVE
  We examined the effects of ingestion of soy protein containing various concentrations of isoflavones on hormone values in postmenopausal women.
  
  
  METHODS
  Seventy-three hypercholesterolemic, free-living, postmenopausal women participated in a 6-mo double-blind trial in which 40 g protein as part of a National Cholesterol Education Program Step I diet was provided as casein from nonfat dry milk (control), isolated soy protein (ISP) containing 56 mg isoflavones (ISP56), or ISP containing 90 mg isoflavones (ISP90). Endogenous hormone concentrations were measured at baseline and at 3 and 6 mo.
  
  
  RESULTS
  The concentration of thyroxine and the free thyroxine index were higher in the ISP56 group, and the concentration of thyroid-stimulating hormone was higher in the ISP90 group than in the control group at 3 and 6 mo (P < 0.05). Triiodothyronine was significantly higher in the ISP90 group only at 6 mo. Thyroxine, free thyroxine index, and thyroid-stimulating hormone at 6 mo were inversely associated with measures of baseline estrogenicity. No significant differences were found for endogenous estrogens, cortisol, dehydroepiandrosterone sulfate, insulin, glucagon, or follicle-stimulating hormone after baseline hormone values were controlled for.
  
  
  CONCLUSIONS
  This study does not provide evidence that long-term ingestion of soy protein alters steroid hormone values, but it suggests that soy protein may have small effects on thyroid hormone values that are unlikely to be clinically important. The thyroid effects are, however, consistent with previous findings in animals and highlight the need for future research investigating possible mechanisms of action.
authors.affiliation: Division of Epidemiology and Biostatistics, the School of Public Health, the University of Illinois at Chicago, USA. vwpersky@uic.edu
authors.forename: Victoria W
authors.initials: VW
authors.lastname: Persky
authors.forename: Mary E
authors.initials: ME
authors.lastname: Turyk
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Sally
authors.initials: S
authors.lastname: Freels
authors.forename: Robert
authors.initials: R
authors.lastname: Chatterton
authors.forename: Stephen
authors.initials: S
authors.lastname: Barnes
authors.forename: John
authors.initials: J
authors.lastname: Erdman
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Sepkovic
authors.forename: H Leon
authors.initials: HL
authors.lastname: Bradlow
authors.forename: Susan
authors.initials: S
authors.lastname: Potter
mesh_terms: D015519:Bone Density; D004032:Diet; D004311:Double-Blind Method; D002149:Energy Intake; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*; D030262:Soybean Proteins / Q000494:pharmacology*
chemical_list: D005419:Flavonoids; D006728:Hormones; D030262:Soybean Proteins