title: Steroid receptor and molecular chaperone encounters in the nucleus.
abstract: Steroid hormone receptors interact with several different molecular chaperones. DeFranco and Csermely discuss how the molecular chaperones p23 and Hsp90 may serve to regulate the activity of the ligand-bound steroid receptors within the nucleus. The authors hypothesize that these chaperone proteins may have a proactive role in promoting recycling of receptors once they have interacted with chromatin and in allowing rebinding of ligand once the receptors have been recycled.
authors.affiliation: Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dod1+@pitt.edu
authors.forename: D B
authors.initials: DB
authors.lastname: DeFranco
authors.forename: P
authors.initials: P
authors.lastname: Csermely
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D018832:Molecular Chaperones / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology*
chemical_list: D018832:Molecular Chaperones; D011987:Receptors, Steroid