title: Mechanisms underlying rapid experience-dependent plasticity in the human visual cortex.
abstract: Visual deprivation induces a rapid increase in visual cortex excitability that may result in better consolidation of spatial memory in animals and in lower visual recognition thresholds in humans. gamma-Aminobutyric acid (GABA)ergic, N-methyl-d-aspartate (NMDA), and cholinergic receptors are thought to be involved in visual cortex plasticity in animal studies. Here, we used a pharmacological approach and found that lorazepam (which enhances GABA(A) receptor function by acting as a positive allosteric modulator), dextrometorphan (NMDA receptor antagonist), and scopolamine (muscarinic receptor antagonist) blocked rapid plastic changes associated with light deprivation. These findings suggest the involvement of GABA, NMDA, and cholinergic receptors in rapid experience-dependent plasticity in the human visual cortex.
authors.affiliation: Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: B
authors.initials: B
authors.lastname: Boroojerdi
authors.forename: F
authors.initials: F
authors.lastname: Battaglia
authors.forename: W
authors.initials: W
authors.lastname: Muellbacher
authors.forename: L G
authors.initials: LG
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000818:Animals; D003915:Dextromethorphan / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D006801:Humans; D008027:Light; D008140:Lorazepam / Q000494:pharmacology; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D010775:Photic Stimulation; D018079:Receptors, GABA / Q000502:physiology; D011976:Receptors, Muscarinic / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D012601:Scopolamine / Q000494:pharmacology; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology*
chemical_list: D018757:GABA Modulators; D018727:Muscarinic Antagonists; D018079:Receptors, GABA; D011976:Receptors, Muscarinic; D016194:Receptors, N-Methyl-D-Aspartate; D003915:Dextromethorphan; D012601:Scopolamine; D008140:Lorazepam