title: Anterior capsule opacification and lens epithelial outgrowth on the intraocular lens surface after curettage.
abstract: OBJECTIVE
  To evaluate the long-term difference in lens epithelial cell (LEC) outgrowth on the anterior surface of a hydrogel intraocular lens (IOL) after curettage of the entire or one half of the circumference of the anterior capsule.
  
  
  METHODS
  Department of Ophthalmology, University of Vienna, Austria.
  
  
  METHODS
  Forty eyes with senile cataract only were randomly assigned to Group A, which had curettage of the entire anterior capsule, or Group B, which had curettage of the nasal half of the anterior capsule. Rentsch capsule curettes (Geuder) were used, a straight one for the nasal half and a bent model for the temporal half. One surgeon performed all standardized procedures with a temporal clear corneal incision, phacoemulsification, and in-the-bag implantation of a hydrogel IOL. Two years after surgery, the anterior surface of the IOL was examined by specular microscopy in a double-blinded fashion, and LEC outgrowth was graded semiquantitatively. Anterior capsule opacification (ACO) was also graded semiquantitatively.
  
  
  RESULTS
  In Group A, grade 2 ACO was observed in 53% of patients and grade 1 ACO in 47%. Similar results were achieved in Group B (59% and 41%, respectively). Two years after IOL implantation, the typically circumferential monolayer outgrowth of LECs on the hydrogel IOL surface was present in 80% in Group A and 60% in Group B. The ongrowth was less dense in the other IOLs; however, no significant differences between the groups were observed.
  
  
  CONCLUSIONS
  Mechanical removal of residual LECs with a Rentsch capsule curette from the entire or from one half of the anterior capsule did not reduce LEC outgrowth 2 years after IOL implantation. Furthermore, the ACO grade was not significantly different. Lens epithelial cell proliferation in the germinative region and consecutive migration might be the cause of this outgrowth.
authors.affiliation: Department of Ophthalmology, University of Vienna, Medical School, Allgemeines Krankenhaus, Vienna, Austria.
authors.forename: A J
authors.initials: AJ
authors.lastname: Kruger
authors.forename: M
authors.initials: M
authors.lastname: Amon
authors.forename: J
authors.initials: J
authors.lastname: Schauersberger
authors.forename: C
authors.initials: C
authors.lastname: Abela-Formanek
authors.forename: G
authors.initials: G
authors.lastname: Schild
authors.forename: J
authors.initials: J
authors.lastname: Kolodjaschna
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000145:classification / Q000175:diagnosis / Q000209:etiology*; D002455:Cell Division; D003475:Curettage; D004311:Double-Blind Method; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007903:Lens Capsule, Crystalline / Q000473:pathology* / Q000601:surgery; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate