title: Risk estimation for fast neutrons with regard to solid cancer.
abstract: In the absence of epidemiological information on the effects of neutrons, their cancer mortality risk coefficient is currently taken as the product of two low-dose extrapolations: the nominal risk coefficient for photons and the presumed maximum relative biological effectiveness of neutrons. This approach is unnecessary. Since linearity in dose is assumed for neutrons at low to moderate effect levels, the risk coefficient can be derived in terms of the excess risk from epidemiological observations at an intermediate dose of gamma rays and an assumed value, R(1), of the neutron RBE relative to this reference dose of gamma rays. Application of this procedure to the A-bomb data requires accounting for the effect of the neutron dose component, which, according to the current dosimetry system, DS86, amounts on average to 11 mGy in the two cities at a total dose of 1 Gy. With R(1) tentatively set to 20 or 50, it is concluded that the neutrons have caused 18% or 35%, respectively, of the total effect at 1 Gy. The excess relative risk (ERR) for neutrons then lies between 8 per Gy and 16 per Gy. Translating these values into risk coefficients in terms of the effective dose, E, requires accounting for the gamma-ray component produced by the neutron field in the human body, which will require a separate analysis. The risk estimate for neutrons will remain essentially unaffected by the current reassessment of the neutron doses in Hiroshima, because the doses are unlikely to change much at the reference dose of 1 Gy.
authors.affiliation: Radiobiological Institute, University of Munich, Germany. amk.sbi@lrz.uni-muenchen.de
authors.forename: A M
authors.initials: AM
authors.lastname: Kellerer
authors.forename: L
authors.initials: L
authors.lastname: Walsh
mesh_terms: D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000378:metabolism; D009689:Nuclear Warfare; D018570:Risk Assessment