title: Prenatal choline supplementation protects against postnatal neurotoxicity.
abstract: Choline, a dietary compound present in many foods, has recently been classified as an essential nutrient for humans. There is evidence from animal models that the availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a 6 d gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of female adolescent rats produced by peripheral administration of the NMDA receptor antagonist dizocilpine (MK-801). These data show that availability of a single nutrient, choline, during a brief period of prenatal development diminishes vulnerability to neurotoxicity in adolescent offspring.
authors.affiliation: Neurobiology Research Laboratory, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA.
authors.forename: Shirley X
authors.initials: SX
authors.lastname: Guo-Ross
authors.forename: Suzanne
authors.initials: S
authors.lastname: Clark
authors.forename: Daniel A C
authors.initials: DA
authors.lastname: Montoya
authors.forename: Katherine H
authors.initials: KH
authors.lastname: Jones
authors.forename: Jennifer
authors.initials: J
authors.lastname: Obernier
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Shetty
authors.forename: Aaron M
authors.initials: AM
authors.lastname: White
authors.forename: Jan Krzysztof
authors.initials: JK
authors.lastname: Blusztajn
authors.forename: Wilkie A
authors.initials: WA
authors.lastname: Wilson
authors.forename: H Scott
authors.initials: HS
authors.lastname: Swartzwelder
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D002452:Cell Count; D002794:Choline / Q000008:administration & dosage*; D019610:Cytoprotection / Q000187:drug effects / Q000502:physiology; D019587:Dietary Supplements; D016291:Dizocilpine Maleate / Q000633:toxicity; D018691:Excitatory Amino Acid Antagonists / Q000633:toxicity*; D005260:Female; D006179:Gyrus Cinguli / Q000166:cytology / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012737:Sex Factors
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D002794:Choline