title: Acute polyosteal osteomyelitis in a patient with congenital ichthyosis and acute lymphoblastic leukemia.
abstract: Osteomyelitis can develop after bacteremia in children and is a rare complication of chemotherapy for acute lymphoblastic leukemia. A child with congenital ichthyosis, acute lymphoblastic leukemia and multifocal hematogenous osteomyelitis is described herein. A breached skin barrier secondary to ichthyosis during induction chemotherapy, coupled with impaired immunity, likely provided the opportunity for bacterial seeding, leading to an extensive multifocal osteomyelitis.
authors.affiliation: Department of Pediatrics, University of Minnesota, St. Paul, MN, USA.
authors.forename: J
authors.initials: J
authors.lastname: Tolar
authors.forename: G
authors.initials: G
authors.lastname: Kravitz
authors.forename: K
authors.initials: K
authors.lastname: Walker
authors.forename: C L
authors.initials: CL
authors.lastname: Moertel
mesh_terms: D016470:Bacteremia / Q000150:complications*; D002648:Child; D006801:Humans; D016113:Ichthyosiform Erythroderma, Congenital / Q000150:complications*; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D011859:Radiography