MR ventilation-perfusion imaging of human lung using oxygen-enhanced and arterial spin labeling techniques.
Magnetic resonance ventilation-perfusion (V/Q) imaging has been demonstrated using oxygen and arterial spin labeling techniques. Inhaled oxygen is used as a paramagnetic contrast agent in ventilation imaging using a multiple inversion recovery (MIR) approach. Pulmonary perfusion imaging is conducted using a flow-sensitive alternating inversion recovery with an extra radiofrequency pulse (FAIRER) technique. A half Fourier single-short turbo spin echo (HASTE) sequence is used for data acquisition in both techniques. V/Q imaging was performed in ten of the twenty volunteers, while either ventilation or perfusion was imaged in the other ten. This V/Q imaging scheme is completely noninvasive, does not involve ionized radiation, and shows promising potential for clinical use in the diagnosis of lung diseases such as pulmonary embolism.
Mai
V M
VM
Department of Radiology, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA. vmai@enh.org
Bankier
A A
AA
Prasad
P V
PV
Li
W
W
Storey
P
P
Edelman
R R
RR
Chen
Q
Q
D000328:Adult; D003287:Contrast Media; D005260:Female; D006801:Humans; D008168:Lung / Q000033:anatomy & histology*; D008171:Lung Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D012680:Sensitivity and Specificity; D013113:Spin Labels; D014692:Ventilation-Perfusion Ratio
D003287:Contrast Media; D013113:Spin Labels; D010100:Oxygen