Cutaneous sclerosing Pacinian-like perineurioma.
OBJECTIVE
The term perineurioma has been used to designate a variety of clinically and histologically different proliferations of perineurial cells based on immunohistochemical and/or ultrastructural characterization. There are two different groups of neoplasms derived from perineurial cells: extraneural or soft tissue perineuriomas, and intraneural perineuriomas. Recently, a sclerosing variant of cutaneous perineurioma has been described.


RESULTS
We report a case of a cutaneous form of perineurioma, combining features of the intraneural and sclerosing varieties, as well as showing a Pacinian pattern of growth. In order to assess the neoplastic nature of the lesion, we performed fluorescence in-situ hybridization (FISH) analysis using a probe which maps to the chromosome band 22q11 and 22q13, allowing us to show deletion or loss of one chromosome 22 in the tumour cells.


CONCLUSIONS
This case may be considered a new variant of perineurioma with Pacinian-like features, for which we propose the designation 'sclerosing Pacinian-like perineurioma'.
Burgues
O
O
Department of Pathology, Hospital Clínico Universitario, University of Valencia, Valencia, Spain.
Monteagudo
C
C
Noguera
R
R
Revert
A
A
Molina
I
I
Llombart-Bosch
A
A
D000328:Adult; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D018396:Mucin-1 / Q000032:analysis; D018317:Nerve Sheath Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D010141:Pacinian Corpuscles / Q000473:pathology; D012598:Sclerosis / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D018396:Mucin-1; D014746:Vimentin