title: Model systems for assessing cognitive function: implications for HIV-1 infection and drugs of abuse.
abstract: Memory deficits are common among drug abusers and in those with chronic neurodegenerative disorders. Currently, the mechanisms through which diverse neurophysiologic processes alter memory are not known. This review describes the current systems and rationale for studying memory formation, consolidation, and recall. Special attention is given to physiologic (hippocampal long-term potentiation) and behavioral animal models. The principles and methods described can be applied to studies of diverse clinical disorders.
authors.affiliation: The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha 68198-5215, USA.
authors.forename: W E
authors.initials: WE
authors.lastname: Zink
authors.forename: J
authors.initials: J
authors.lastname: Boyle
authors.forename: Y
authors.initials: Y
authors.lastname: Persidsky
authors.forename: H
authors.initials: H
authors.lastname: Xiong
authors.forename: H E
authors.initials: HE
authors.lastname: Gendelman
mesh_terms: D015526:AIDS Dementia Complex / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning; D003071:Cognition / Q000502:physiology; D004195:Disease Models, Animal; D015658:HIV Infections / Q000523:psychology*; D015497:HIV-1; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D017774:Long-Term Potentiation; D018782:Maze Learning; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000209:etiology* / Q000523:psychology; D011939:Mental Recall; D051379:Mice; D009294:Narcotics / Q000633:toxicity; D051381:Rats; D015398:Signal Transduction; D019966:Substance-Related Disorders / Q000523:psychology*
chemical_list: D009294:Narcotics