title: Acute coalescent mastoiditis and acoustic sequelae in an infant with severe congenital neutropenia.
abstract: We report a 2-month-old boy with severe congenital neutropenia (SCN), who developed acute necrotizing otitis media and coalescent mastoiditis due to methicillin-sensitive Staphylococcus aureus. The infection fulminantly progressed within a day to a subtotal perforation of the tympanic membrane, destructive bony changes of ossicles, lateral subperiosteal abscess, and suppurative labyrinthitis. Despite the combined treatment with intravenous antibiotics and granulocyte colony-stimulating factor, the infection resulted in mixed hearing impairment. Much attention should be given to prompt diagnosis of otomastoiditis in SCN, a rare congenital disorder, since resultant acoustic sequelae may affect subsequent speech development and intellectual ability.
authors.affiliation: Department of Pediatrics, Nishi-Kobe Medical Center, 5-7-1 Kojidai, Nishi-Ku, 651-2273, Kobe, Japan. kskmatsu@portnet.ne.jp
authors.forename: Kousaku
authors.initials: K
authors.lastname: Matsubara
authors.forename: Koichi
authors.initials: K
authors.lastname: Omori
authors.forename: Kunizo
authors.initials: K
authors.lastname: Baba
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents; D001299:Audiometry; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006311:Hearing Disorders / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D008417:Mastoiditis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D009503:Neutropenia / Q000150:complications / Q000151:congenital* / Q000188:drug therapy; D010034:Otitis Media with Effusion / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D013203:Staphylococcal Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D016179:Granulocyte Colony-Stimulating Factor