title: Genetic alterations in endometrial hyperplasia and cancer.
abstract: Putative precursors of endometrial cancer such as complex endometrial hyperplasia with atypia have been described to be monoclonal and considered to be genetically related. In order to identify a genetic marker that could serve as a putative predictor of endometrial cancer we analyzed 14 endometrial hyperplasia and 29 endometrial cancer samples for instabilities and loss of heterozygosity (LOH) in microsatellite sequences. Deletions on the short arm of chromosome 8 were frequently detected in both endometrial hyperplasia and cancer samples, suggesting that these deletions are early events in the development of endometrial cancer.
authors.affiliation: Department of Gynecology and Obstetrics, University of Vienna, Medical School, Waehringer Guertel 18-20, EBO 05 A-1090, Vienna, Austria.
authors.forename: Gerhild
authors.initials: G
authors.lastname: Fabjani
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Kucera
authors.forename: Eva
authors.initials: E
authors.lastname: Schuster
authors.forename: Michael
authors.initials: M
authors.lastname: Minai-Pour
authors.forename: Klaus
authors.initials: K
authors.lastname: Czerwenka
authors.forename: Gerhard
authors.initials: G
authors.lastname: Sliutz
authors.forename: Sepp
authors.initials: S
authors.lastname: Leodolter
authors.forename: Angelika
authors.initials: A
authors.lastname: Reiner
authors.forename: Robert
authors.initials: R
authors.lastname: Zeillinger
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D004273:DNA, Neoplasm / Q000302:isolation & purification; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D006965:Hyperplasia; D018895:Microsatellite Repeats / Q000235:genetics; D009154:Mutation; D016133:Polymerase Chain Reaction
chemical_list: D004273:DNA, Neoplasm