title: Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.
abstract: We have identified a migraine locus on chromosome 19p13.3/2 using linkage and association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of which we genotyped 24 in a Caucasian population comprising 827 unrelated cases and 765 controls. Five single-nucleotide polymorphisms within the insulin receptor gene showed significant association with migraine. This association was independently replicated in a case-control population collected separately. We used experiments with insulin receptor RNA and protein to investigate functionality for the migraine-associated single-nucleotide polymorphisms. We suggest possible functions for the insulin receptor in migraine pathogenesis.
authors.affiliation: GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK. lm93678@gsk.com
authors.forename: L C
authors.initials: LC
authors.lastname: McCarthy
authors.forename: D A
authors.initials: DA
authors.lastname: Hosford
authors.forename: J H
authors.initials: JH
authors.lastname: Riley
authors.forename: M I
authors.initials: MI
authors.lastname: Bird
authors.forename: N J
authors.initials: NJ
authors.lastname: White
authors.forename: D R
authors.initials: DR
authors.lastname: Hewett
authors.forename: S J
authors.initials: SJ
authors.lastname: Peroutka
authors.forename: L R
authors.initials: LR
authors.lastname: Griffiths
authors.forename: P R
authors.initials: PR
authors.lastname: Boyd
authors.forename: R A
authors.initials: RA
authors.lastname: Lea
authors.forename: S M
authors.initials: SM
authors.lastname: Bhatti
authors.forename: L K
authors.initials: LK
authors.lastname: Hosking
authors.forename: C M
authors.initials: CM
authors.lastname: Hood
authors.forename: K W
authors.initials: KW
authors.lastname: Jones
authors.forename: A R
authors.initials: AR
authors.lastname: Handley
authors.forename: R
authors.initials: R
authors.lastname: Rallan
authors.forename: K F
authors.initials: KF
authors.lastname: Lewis
authors.forename: A J
authors.initials: AJ
authors.lastname: Yeo
authors.forename: P M
authors.initials: PM
authors.lastname: Williams
authors.forename: R C
authors.initials: RC
authors.lastname: Priest
authors.forename: P
authors.initials: P
authors.lastname: Khan
authors.forename: C
authors.initials: C
authors.lastname: Donnelly
authors.forename: S M
authors.initials: SM
authors.lastname: Lumsden
authors.forename: J
authors.initials: J
authors.lastname: O'Sullivan
authors.forename: C G
authors.initials: CG
authors.lastname: See
authors.forename: D H
authors.initials: DH
authors.lastname: Smart
authors.forename: S
authors.initials: S
authors.lastname: Shaw-Hawkins
authors.forename: J
authors.initials: J
authors.lastname: Patel
authors.forename: T C
authors.initials: TC
authors.lastname: Langrish
authors.forename: W
authors.initials: W
authors.lastname: Feniuk
authors.forename: R G
authors.initials: RG
authors.lastname: Knowles
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: V
authors.initials: V
authors.lastname: Libri
authors.forename: D S
authors.initials: DS
authors.lastname: Montgomery
authors.forename: P K
authors.initials: PK
authors.lastname: Manasco
authors.forename: C F
authors.initials: CF
authors.lastname: Xu
authors.forename: C
authors.initials: C
authors.lastname: Dykes
authors.forename: P P
authors.initials: PP
authors.lastname: Humphrey
authors.forename: A D
authors.initials: AD
authors.lastname: Roses
authors.forename: I J
authors.initials: IJ
authors.lastname: Purvis
mesh_terms: D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D002874:Chromosome Mapping; D022202:Chromosomes, Artificial, Bacterial; D002888:Chromosomes, Human, Pair 19; D017931:DNA Primers; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011485:Protein Binding; D011972:Receptor, Insulin / Q000235:genetics* / Q000378:metabolism; D015203:Reproducibility of Results; D044465:White People / Q000235:genetics
chemical_list: D017931:DNA Primers; D011972:Receptor, Insulin