title: Long-term treatment with citalopram in patients with highly recurrent forms of unipolar depression.
abstract: The authors evaluated the efficacy and safety of citalopram in a 28-month study in 48 inpatients with highly recurrent forms of unipolar depression. The patients, who each had at least one depressive episode during the 18 months preceding the index episode, were openly treated with citalopram, 40 mg/day. Thirty-six of the patients had a stable response to citalopram and continued treatment as outpatients for 4 months. No relapses were observed. At the time of recovery, 32/36 subjects received maintenance treatment with citalopram (40 mg) for an additional 24 months. At the end of the study, 11/32 patients experienced a single new recurrence.
authors.affiliation: Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Università Vita e Salute, Via Luigi Prinetti, 29, 20127, Milan, Italy. franchini.linda@hsr.it
authors.forename: L
authors.initials: L
authors.lastname: Franchini
authors.forename: C
authors.initials: C
authors.lastname: Spagnolo
authors.forename: R
authors.initials: R
authors.lastname: Rampoldi
authors.forename: R
authors.initials: R
authors.lastname: Zanardi
authors.forename: E
authors.initials: E
authors.lastname: Smeraldi
mesh_terms: D000328:Adult; D015283:Citalopram / Q000008:administration & dosage* / Q000009:adverse effects; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D015283:Citalopram