title: Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma.
abstract: BACKGROUND
  Two randomized, double-blind trials have compared tamoxifen 20 mg daily and the selective, nonsteroidal aromatase inhibitor anastrozole 1 mg daily as first-line therapy for advanced breast carcinoma (ABC) in postmenopausal women. The trials were prospectively designed to allow for combined data analyses.
  
  
  METHODS
  The combined study population included 1021 postmenopausal women (median age, 67 years [range, 30-92]) with ABC whose tumors were either estrogen and/or progesterone receptor positive or of unknown receptor status. Primary endpoints were time to progression (TTP), objective response, and tolerability.
  
  
  RESULTS
  At a median duration of follow-up of 18.2 months, anastrozole was at least equivalent to tamoxifen in terms of median TTP (8.5 and 7.0 months, respectively; estimated hazard ratio [tamoxifen relative to anastrozole], 1.13 [lower 95% confidence level, 1.00]). In a retrospective subgroup analysis, anastrozole was superior to tamoxifen with respect to TTP (median values of 10.7 and 6.4 months for anastrozole and tamoxifen, respectively, two-sided P = 0.022) in patients with estrogen and/or progesterone receptor positive tumors (60% of combined trial population). In terms of objective response, 29.0% of anastrozole and 27.1% of tamoxifen patients achieved either a complete response (CR) or a partial response (PR). Clinical benefit (CR + PR + stabilization of > or = 24 weeks) rates were 57.1% and 52.0% for anastrozole and tamoxifen, respectively. Both anastrozole and tamoxifen were well tolerated. Anastrozole led to significantly fewer venous thromboembolic (P = 0.043; not adjusted for multiple comparisons) events, and vaginal bleeding was reported in fewer patients treated with anastrozole than with tamoxifen.
  
  
  CONCLUSIONS
  In postmenopausal women with hormonally sensitive ABC, anastrozole should be considered as the new standard first-line treatment.
authors.affiliation: Centre Oscar Lambret, Lille, France.
authors.forename: J
authors.initials: J
authors.lastname: Bonneterre
authors.forename: A
authors.initials: A
authors.lastname: Buzdar
authors.forename: J M
authors.initials: JM
authors.lastname: Nabholtz
authors.forename: J F
authors.initials: JF
authors.lastname: Robertson
authors.forename: B
authors.initials: B
authors.lastname: Thürlimann
authors.forename: M
authors.initials: M
authors.lastname: von Euler
authors.forename: T
authors.initials: T
authors.lastname: Sahmoud
authors.forename: A
authors.initials: A
authors.lastname: Webster
authors.forename: M
authors.initials: M
authors.lastname: Steinberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D009570:Nitriles / Q000494:pharmacology*; D017698:Postmenopause; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D016019:Survival Analysis; D013629:Tamoxifen / Q000494:pharmacology*; D013923:Thromboembolism / Q000139:chemically induced; D016896:Treatment Outcome; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014230:Triazoles; D013629:Tamoxifen; D000077384:Anastrozole