The fuss about Mus81.
Endonucleolytic cleavage of Holliday junctions is important in recombination and replication. Mus81 proteins in yeasts and humans appear to have many, but not all, of the expected properties of eukaryotic Holliday junction resolvases, with intriguing connections to DNA replication checkpoints.
Haber
J E
JE
Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02254, USA.
Heyer
W D
WD
D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004706:Endodeoxyribonucleases / Q000378:metabolism; D004720:Endonucleases; D045585:Flap Endonucleases; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D045565:Holliday Junction Resolvases; D006801:Humans; D011995:Recombination, Genetic; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism
D004271:DNA, Fungal; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D004247:DNA; D004706:Endodeoxyribonucleases; D004720:Endonucleases; D045585:Flap Endonucleases; C498772:MUS81 protein, human; D045565:Holliday Junction Resolvases; C112337:MMS4 protein, S cerevisiae