title: Aglacins A-D, first representatives of a new class of aryltetralin cyclic ether lignans from Aglaia cordata.
abstract: Four new metabolites, aglacins A-D (1-4), were identified from the methanol extract of the stem bark of Aglaia cordata. These compounds represent a new class of aryltetralin cyclic ether lignan. The structure of aglacin A (1) including the absolute configuration was elucidated by interpretation of spectral data, X-ray crystal structure determination, and employing the modified Mosher's method. In addition, three other derivatives, aglacins B-D (2-4), were isolated and identified by spectral means.
authors.affiliation: Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.
authors.forename: B G
authors.initials: BG
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Ebel
authors.forename: B W
authors.initials: BW
authors.lastname: Nugroho
authors.forename: D
authors.initials: D
authors.lastname: Prijono
authors.forename: W
authors.initials: W
authors.lastname: Frank
authors.forename: K G
authors.initials: KG
authors.lastname: Steube
authors.forename: X J
authors.initials: XJ
authors.lastname: Hao
authors.forename: P
authors.initials: P
authors.lastname: Proksch
mesh_terms: D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004988:Ethers, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007214:Indonesia; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D029582:Meliaceae / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D004988:Ethers, Cyclic; D017705:Lignans