Improvement of anti-Hu-associated paraneoplastic sensory neuropathy after chemoradiotherapy in a small cell lung cancer patient.
A 66-year-old man developed progressive painful dysesthesia in his hands and feet over 3 months. His vibration sense was impaired and sensory nerve action potentials of the limbs were not evoked. Biopsy of the peroneal nerve revealed sensory neuropathy. Positive anti-Hu antibody facilitated delineation of a right hilar mass and a metastatic lymph node in thoracic CT scan. He was diagnosed as small cell lung cancer associated with paraneoplastic sensory neuropathy. A complete response was achieved through chemotherapy (carboplatin and etoposide) and subsequent radiation therapy. Notably, his neurological conditions, although not changed during the hospitalization, gradually improved afterwards.
Suzuki
M
M
Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita.
Kimura
H
H
Tachibana
I
I
Fujimura
H
H
Nakatsuji
Y
Y
Sugai
F
F
Naba
I
I
Nakamori
M
M
Morishita
H
H
Arai
T
T
Osaki
T
T
Hayashi
S
S
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy*; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy*; D008297:Male; D020364:Paraneoplastic Polyneuropathy / Q000276:immunology*; D016896:Treatment Outcome
D001323:Autoantibodies; D005047:Etoposide; D016190:Carboplatin