Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites.
Environmental conditions in early life permanently alter the development of glucocorticoid receptor gene expression in the hippocampus and hypothalamic-pituitary-adrenal responses to acute or chronic stress. In part, these effects can involve an activation of ascending serotonergic pathways and subsequent changes in the expression of transcription factors that might drive glucocorticoid receptor expression in the hippocampus. This paper summarizes the evidence in favor of these pathways as well as recent studies describing regulatory targets on the promoter region of the rat hippocampal glucocorticoid receptor gene.
Weaver
I C
IC
McGill program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 LaSalle Blvd., Montreal, Quebec, Canada H4H 1R3.
La Plante
P
P
Weaver
S
S
Parent
A
A
Sharma
S
S
Diorio
J
J
Chapman
K E
KE
Seckl
J R
JR
Szyf
M
M
Meaney
M J
MJ
D000818:Animals; D004777:Environment; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000502:physiology; D011965:Receptors, Glucocorticoid / Q000235:genetics* / Q000378:metabolism; D012701:Serotonin / Q000502:physiology; D013312:Stress, Physiological / Q000378:metabolism
D011965:Receptors, Glucocorticoid; D012701:Serotonin