PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection.
Stepkowski
S M
SM
Division of Immunology and Organ Transplantation, University of Texas-Houston, Houston, Texas, USA.
Nagy
Z S
ZS
Wang
M E
ME
Behbod
F
F
Erwin-Cohen
R
R
Kahan
B D
BD
Kirken
R A
RA
D000818:Animals; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D053616:Janus Kinase 3; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011758:Pyrroles / Q000627:therapeutic use*; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014184:Transplantation, Homologous
C119625:4-benzyloxy-5-((5-undecyl-2H-pyrrol-2-ylidene)methyl)-2,2'-bi-1H-pyrrole; D007166:Immunosuppressive Agents; C507936:Jak3 protein, rat; D011758:Pyrroles; D011505:Protein-Tyrosine Kinases; C507933:JAK3 protein, human; D053616:Janus Kinase 3; D011353:Prodigiosin