title: Synthesis and antinephritic activities of quinoline-3-carboxamides and related compounds.
abstract: A series of linomide-related quinoline-3-carboxamides and their analogues was prepared and evaluated for antinephritic activities. The 6-MeS derivative 7a was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.
authors.affiliation: Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, 1-6, Kashima 2-chome,Yodogawa-ku, 532-8514, Osaka, Japan. kiyoshi_tsuji@po.fujisawa.co.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tsuji
authors.forename: Glen W
authors.initials: GW
authors.lastname: Spears
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nakamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Tojo
authors.forename: Nobuo
authors.initials: N
authors.lastname: Seki
authors.forename: Aiko
authors.initials: A
authors.lastname: Sugiyama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Matsuo
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000974:Antibodies, Antinuclear / Q000187:drug effects; D001327:Autoimmune Diseases / Q000188:drug therapy; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006086:Graft vs Host Disease / Q000188:drug therapy; D051379:Mice; D019463:Mice, Inbred MRL lpr; D009393:Nephritis / Q000188:drug therapy*; D011507:Proteinuria / Q000188:drug therapy; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000974:Antibodies, Antinuclear; D011804:Quinolines