Renal abnormalities in a population of patients with psoriatic arthritis.
OBJECTIVE
To investigate the prevalence of and to identify predictive factors for renal abnormalities in patients with psoriatic arthritis (PsA).


METHODS
73 patients with PsA were consecutively examined by laboratory analyses and clinically for joint manifestations. Renal function was estimated by creatinine clearance and urinary albumin.


RESULTS
17 (23.3%) of the patients had renal abnormalities as defined by creatinine clearance below the lower cut off of normal distribution (mean - 2 SD) and/or urinary excretion of albumin more than 25 mg/24 h. These patients were significantly older at the time of the study, older at joint disease onset, had longer skin disease duration, increased serum levels of beta2-microglobulin, and higher incidence of increased ESR and/or CRP levels. Increased ESR/CRP levels had significantly predictive value in multivariate analysis.


CONCLUSIONS
In this study subclinical renal abnormalities was a prevalent finding. Predictive factor was inflammatory activity measured by laboratory variables. There were no predisposing effects of NSAID or DMARD therapy.
Alenius
G M
GM
Rheumatology, Department of Public Health and Clinical Medicine, Umeå University, Sweden.
Stegmayr
B G
BG
Dahlqvist
S R
SR
D000328:Adult; D000419:Albuminuria / Q000209:etiology; D015535:Arthritis, Psoriatic / Q000150:complications*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
D003404:Creatinine