title: The genetics and epigenetics of orofacial clefts.
abstract: Orofacial clefts (cleft lip, cleft palate) are among the most common of all major birth defects, but very little is known about their causation. Genetic factors are thought to play a major role, and there has been considerable recent effort to map and identify genes that constitute risk factors for clefts. This review will put into perspective the frequently-conflicting results of these studies.
authors.affiliation: Department of Pediatrics and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Spritz
mesh_terms: D002971:Cleft Lip / Q000235:genetics* / Q000503:physiopathology; D002972:Cleft Palate / Q000235:genetics* / Q000503:physiopathology; D005492:Folic Acid / Q000502:physiology; D008040:Genetic Linkage; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D051957:MSX1 Transcription Factor; D009154:Mutation; D013577:Syndrome; D020825:T-Box Domain Proteins / Q000235:genetics; D014157:Transcription Factors
chemical_list: D018398:Homeodomain Proteins; D051957:MSX1 Transcription Factor; D020825:T-Box Domain Proteins; C416943:TBX22 protein, human; D014157:Transcription Factors; D005492:Folic Acid