Effect of calcium antagonists on ultrastructure of myocardial microvessels during open heart surgery under conditions of pharmacological and cold cardioplegia.
Ultrastructure of myocardial microvessels was examined during surgical correction of congenital heart disease (ventricular septal defect) under conditions of cold and pharmacological low-potassium cardioplegia without perfusion. Addition of calcium antagonist verapamil to cardioplegic solution prevented postischemic damage to vascular and perivascular structures occurring during reperfusion and body temperature rise.
Volkov
A M
AM
Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Novosibirsk.
Kazanskaya
G M
GM
Chasovskikh
G G
GG
D'yakonitsa
T M
TM
Zhdanov
G P
GP
Lomivorotov
V N
VN
D001831:Body Temperature; D002118:Calcium / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006348:Cardiac Surgical Procedures; D002648:Child; D003080:Cold Temperature; D006321:Heart / Q000187:drug effects; D006324:Heart Arrest, Induced; D006325:Heart Atria / Q000378:metabolism / Q000648:ultrastructure; D006331:Heart Diseases / Q000151:congenital; D006801:Humans; D007035:Hypothermia; D007511:Ischemia; D008833:Microcirculation / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D013696:Temperature; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D002118:Calcium