Comparative in vitro activity of ABT-773 and two macrolides against staphylococci.
The anti-staphylococcal activity of ABT-773, a new member of the ketolides, was examined and compared with those of erythromycin and clarithromycin using the agar dilution method. A total of 336 well-defined clinical isolates of staphylococci, including a large number of clonally different methicillin-resistant strains with defined macrolide-lincosamide-streptogramin B (MLS(B)) resistance phenotypes were tested. The novel ketolide exhibited broad-spectrum anti-staphylococcal activity against both methicillin-susceptible and methicillin-resistant strains. Apart from strains with constitutive expression of MLS(B) resistance, all staphylococcal strains tested were inhibited by < or = 0.063 mg/L of ABT-773, irrespective of the resistance phenotype for methicillin.
von Eiff
Christof
C
Institute of Medical Microbiology, University of Münster Hospital and Clinics, 48149 Münster, Germany. eiffc@uni-muenster.de
Peters
Georg
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D048628:Ketolides; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D013210:Staphylococcus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D048628:Ketolides; D004917:Erythromycin; D017291:Clarithromycin; C405499:cethromycin