Combinatorial approaches to formulation development.
This review describes the use of combinatorial methods for the development of drug formulations. Combinatorial methods are applied to find solutions to various formulation problems, including drug solubilization, controlled release, oral drug administration, and others. Various methods are described, including the synthesis of carrier libraries, high-throughput screening and computational analysis, which are used during the formulation development process, starting from initial assays through the optimization of formulation composition, to the optimization of the manufacturing process. This review also describes an integrated approach to drug formulation development using libraries of block copolymers as the drug carriers.
Alakhov
V
V
Supratek Pharma Inc, 531 Boulevard des Prairies, Building 18, Laval, Quebec H7B 1B7, Canada. valery.alakhov@supratek.com
Pietrzynski
G
G
Kabanov
A
A
D000818:Animals; D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D015195:Drug Design; D006801:Humans