title: Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway.
abstract: In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.
authors.affiliation: Department of Neurology, University of California, San Francisco, CA 94143-0984, USA.
authors.forename: J
authors.initials: J
authors.lastname: Whistler
authors.forename: E
authors.initials: E
authors.lastname: Beattie
authors.forename: M
authors.initials: M
authors.lastname: von Zastrow
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D011956:Receptors, Cell Surface / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C085003:Gpr12 protein, mouse; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D019204:GTP-Binding Proteins