Pharmacodynamic interaction of doxycycline and artemisinin in Plasmodium falciparum.
Parallel in vitro tests, assessing the inhibition of schizont maturation, were conducted with 31 fresh isolates of Plasmodium falciparum from Thailand, using artemisinin, doxycycline, and combinations of both. The activities of artemisinin and doxycycline are obviously not correlated. Both compounds showed consistent synergism at 50% effective concentration (EC(50)), EC(90), and EC(99) levels.
Sponer
Ulrike
U
Department of Specific Prophylaxis and Tropical Medicine, Institute of Pathophysiology, University of Vienna, A-1095 Vienna, Austria.
Prajakwong
Somsak
S
Wiedermann
Gerhard
G
Kollaritsch
Herwig
H
Wernsdorfer
Gunther
G
Wernsdorfer
Walther H
WH
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D004318:Doxycycline / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin; D004318:Doxycycline