Lycopene inhibits DNA damage and liver necrosis in rats treated with ferric nitrilotriacetate.
Experimental and epidemiological evidence suggests that lycopene, a carotenoid present in tomatoes, tomato products, and several fruits and vegetables, may play a role in preventing certain cancers in humans. We have investigated the effect of lycopene pretreatment on lipid peroxidation, oxidative damage to DNA, and histopathological changes in liver of animals subjected to intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) administration. Compared with control rats, liver of Fe-NTA-treated animals showed a significant increase in the 8-oxo-7,8-dihydro-2'-deoxyguanosine level and a 75% increase in malondialdehyde accumulation concomitant with histopathological changes. Five days of lycopene pretreatment (10 mg/kg body weight, ip) almost completely prevented liver biomolecule oxidative damage and protected the tissue against the observed histological alterations.
Matos
H R
HR
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05513-970 São Paulo, SP, Brazil.
Capelozzi
V L
VL
Gomes
O F
OF
Mascio
P D
PD
Medeiros
M H
MH
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D002338:Carotenoids / Q000494:pharmacology*; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000096:biosynthesis; D005290:Ferric Compounds; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D000077276:Lycopene; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism / Q000494:pharmacology; D009336:Necrosis; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives*; D011837:Radiation-Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D005290:Ferric Compounds; D011837:Radiation-Protective Agents; D002338:Carotenoids; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine; D009571:Nitrilotriacetic Acid; D000077276:Lycopene; C020326:ferric nitrilotriacetate