Are there any news in bladder reconstructive surgery? Some remarks on the state of the art in animal research.
In order to prevent both metabolic and neoplastic complications of intestinal neobladder, various solutions have been proposed to get a truly artificial neobladder: total alloplastic prosthetic bladder in nonbiological material (silicon rubber, polyurethane, etc.), tissue-engineered bladder by autologous urothelial- and smooth muscle cells cultured on biocompatible, either synthetic or natural, substrates. Polymers of glycolic and lactic acid have been extensively used to provide cell delivery matrices. Natural-based materials such as acellular matrix and small intestinal submucosa appear to supply a useful scaffold for regeneration of the wall components in augmentation cystoplasty. Up to day, other roads are less practicable, e.g. to obtain spare bladders from human cloning or from xenogenic sources of transplantable organs.
Alberti
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L. D. of Surgical Semeiotics, University of Parma, Italy.
D000818:Animals; D001743:Urinary Bladder / Q000601:surgery*; D013520:Urologic Surgical Procedures / Q000379:methods