Expression of the Dan gene during chicken embryonic development.
The Dan gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. Xenopus DAN, as with Cerberus and Gremlin, was demonstrated to block bone morphogenetic protein (BMP) signaling by binding BMPs, and to be capable of inducing additional anterior structures by ectopic overexpression in Xenopus embryos. DAN, thus, is suggested to play pivotal roles in early patterning and subsequent organ development, as in the case of other BMP antagonists. In this report, we isolated the chicken counterpart of Dan. Chicken Dan is mainly expressed in the cephalic and somitic mesoderm and several placodes during organ development.
Ogita
J
J
Department of Molecular Embryology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan.
Isogai
E
E
Sudo
H
H
Sakiyama
S
S
Nakagawara
A
A
Koseki
H
H
D000595:Amino Acid Sequence; D000818:Animals; D018797:Cell Cycle Proteins; D002642:Chick Embryo; D018076:DNA, Complementary / Q000378:metabolism; D006801:Humans; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D011506:Proteins; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014018:Tissue Distribution; D014981:Xenopus; D029867:Xenopus Proteins
D018797:Cell Cycle Proteins; D018076:DNA, Complementary; C490085:NBL1 protein, Xenopus; C490087:NBL1 protein, human; D011506:Proteins; D029867:Xenopus Proteins