Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.
Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia. A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF. A skin biopsy specimen revealed microscopic, sterile, neutrophilic abscesses. A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF. A biopsy specimen showed neutrophilic panniculitis. We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.
Prendiville
J
J
Division of Dermatology, British Columbia's Children's Hospital and University of British Columbia, Vancouver, Canada.
Thiessen
P
P
Mallory
S B
SB
D000293:Adolescent; D003875:Drug Eruptions / Q000473:pathology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000188:drug therapy*; D009504:Neutrophils / Q000473:pathology; D015434:Panniculitis / Q000139:chemically induced* / Q000473:pathology
D016179:Granulocyte Colony-Stimulating Factor