title: Hodgkin's lymphoma of T-cell type: clonal association with a CD30+ cutaneous lymphoma.
abstract: The derivation of Reed-Sternberg cells in Hodgkin's lymphoma has been a subject of great interest. In most cases, Reed-Sternberg cells seem to be derived from germinal center B cells. In few sporadic cases, a T-cell origin has been shown. This article supports the concept of a T-cell derivation for rare cases of Hodgkin's lymphoma and provides evidence of a novel mechanism of pathogenesis from chronic inflammation in the skin.
authors.affiliation: Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Kadin
authors.forename: R
authors.initials: R
authors.lastname: Drews
authors.forename: A
authors.initials: A
authors.lastname: Samel
authors.forename: A
authors.initials: A
authors.lastname: Gilchrist
authors.forename: O
authors.initials: O
authors.lastname: Kocher
mesh_terms: D001483:Base Sequence; D002999:Clone Cells; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006689:Hodgkin Disease / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis* / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000737:chemistry / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D018807:Polymorphism, Single-Stranded Conformational; D016539:Reed-Sternberg Cells / Q000737:chemistry*; D012689:Sequence Homology, Nucleic Acid; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000737:chemistry / Q000150:complications* / Q000235:genetics
chemical_list: D017730:Ki-1 Antigen