Administration of two antagonists of the cholecystokinin(B)/gastrin receptor does not totally inhibit the pancreatic response to a meal in the pig.
OBJECTIVE
The role of the cholecystokinin B (CCK(B))/gastrin receptor in the pancreatic response to a standard meal was investigated in the pig.


METHODS
Twenty-four pigs were prepared surgically for the collection of the pancreatic juice and an intravenous perfusion. On experimental days, the pigs were perfused with one of two CCK(B)antagonists (L-365,260 or PD 135156) or the vehicle for 2 hours. We offered them a standard meal 30 minutes after the beginning of the perfusion. The pancreatic secretion was collected for 4 hours starting 30 minutes before the perfusion. Its volume was recorded, and the protein concentrations were assayed.


RESULTS
Neither antagonist totally abolished the postprandial peak of the pancreatic protein.


CONCLUSIONS
We suggest that the stimulation of pancreatic protein secretion by a meal is not mediated by CCK(B)/gastrin receptors. Because we previously showed that the CCK(A)receptor antagonist MK329 was no more able to abolish this response, CCK is probably not responsible for this response.
Lhoste
Evelyne F
EF
Unité d'Ecologie et de Physiologie du Système Digestif, Institut National de la Recherche Argonomique Domaine de Vilvert, Jouy-en-Josas, France. lhoste@biotec.jouy.inra.fr
Fiszlewicz
Michèle
M
Corring
Tristan
T
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating; D008297:Male; D023421:Models, Animal; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010477:Perfusion; D010671:Phenylurea Compounds / Q000494:pharmacology*; D019518:Postprandial Period; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D013552:Swine
D001570:Benzodiazepinones; D004151:Dipeptides; C446221:PD 135156; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C058121:L 365260