No evidence of linkage between Mitsuda reaction and the NRAMP1 locus.
Thirty sib-pairs were ascertained through unrelated lepromatous probands. They consisted of 22 healthy individuals and 8 leprosy patients. The Mitsuda reactions of all sibs were evaluated both macroscopically and histologically, and high molecular weight genomic DNA was extracted from the white blood cells of all sib-pairs. Three DNA polymorphisms identified by polymerase chain reaction (274C/T, D543N, 1729 + 55del4) were used as chromosome markers at the NRAMP1 locus. Sib-pair comparisons did not disclose any sign of close linkage between the Mitsuda reaction and the genetic markers.
Hatagima
A
A
Departmento de Genetica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
Opromolla
D V
DV
Ura
S
S
Feitosa
M F
MF
Beiguelman
B
B
Krieger
H
H
D000328:Adult; D027682:Cation Transport Proteins / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007916:Lepromin / Q000008:administration & dosage*; D007918:Leprosy / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000276:immunology*; D009679:Nuclear Family; D000099173:Natural Resistance-associated Macrophage Protein 1
D027682:Cation Transport Proteins; D007916:Lepromin; D000099173:Natural Resistance-associated Macrophage Protein 1