Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders.
It is known that the concentrations of essential fatty acids and their metabolites including eicosanoids, free radicals and anti-oxidants are altered in glomerular disorders. Both corticosteroids and n-3 fatty acids--eicosapentaenoic acid and docosahexaenoic acid (EPA and DHA respectively)--are useful in the management of glomerular disorders. In the present study, the altered plasma concentrations of lipid peroxides, nitric oxide and the metabolites of essential fatty acids and anti-oxidants--superoxide dismutase, glutathione peroxidase and vitamin E--in the RBC membranes of patients with glomerular disorders (nephrotic syndrome) reverted to normalcy following corticosteroids or EPA/DHA administration. This suggests that the beneficial actions of corticosteroids and EPA/DHA in glomerular disorders can be attributed to their action on the pro-oxidant and anti-oxidant concentrations and metabolism of essential fatty acids.
Das
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EFA Sciences LLC, Norwood, MA 02062, USA.
Mohan
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Raju
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D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000097:blood; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood; D009404:Nephrotic Syndrome / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D009569:Nitric Oxide / Q000097:blood; D010084:Oxidation-Reduction / Q000187:drug effects; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000305:Adrenal Cortex Hormones; D000975:Antioxidants; D005228:Fatty Acids, Essential; D008054:Lipid Peroxides; D014810:Vitamin E; D004281:Docosahexaenoic Acids; D009569:Nitric Oxide; D015118:Eicosapentaenoic Acid; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase