title: Use of FT-NIR transmission spectroscopy for the quantitative analysis of an active ingredient in a translucent pharmaceutical topical gel formulation.
abstract: The objective of this study was to demonstrate the use of transmission Fourier transform near-infrared (FT-NIR) spectroscopy for quantitative analysis of an active ingredient in a translucent gel formulation. Gels were prepared using Carbopol 980 with 0%, 1%, 2%, 4%, 6%, and 8% ketoprofen and analyzed with an FT-NIR spectrophotometer operated in the transmission mode. The correlation coefficient of the calibration was 0.9996, and the root mean squared error of calibration was 0.0775%. The percent relative standard deviation for multiple measurements was 0.10%. The results prove that FT-NIR can be a good alternative to other, more time-consuming means of analysis for these types of formulations.
authors.affiliation: Thermo Nicolet Corporation, Madison, WI 53711, USA. kemper@thermonicolet.com
authors.forename: M S
authors.initials: MS
authors.lastname: Kemper
authors.forename: E J
authors.initials: EJ
authors.lastname: Magnuson
authors.forename: S R
authors.initials: SR
authors.lastname: Lowry
authors.forename: W J
authors.initials: WJ
authors.lastname: McCarthy
authors.forename: N
authors.initials: N
authors.lastname: Aksornkoae
authors.forename: D C
authors.initials: DC
authors.lastname: Watts
authors.forename: J R
authors.initials: JR
authors.lastname: Johnson
authors.forename: A J
authors.initials: AJ
authors.lastname: Shukla
mesh_terms: D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000032:analysis*; D005583:Fourier Analysis; D005782:Gels; D007660:Ketoprofen / Q000008:administration & dosage / Q000032:analysis*; D019265:Spectroscopy, Near-Infrared
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D007660:Ketoprofen