Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein-Barr virus animal model.
We sequenced the rhesus lymphocryptovirus (LCV) genome in order to determine its genetic similarity to Epstein-Barr virus (EBV). The rhesus LCV encodes a repertoire identical to that of EBV, with 80 open reading frames, including cellular interleukin-10, bcl-2, and colony-stimulating factor 1 receptor homologues and an equivalent set of viral glycoproteins. The highly conserved rhesus LCV gene repertoire provides a unique animal model for the study of EBV pathogenesis.
Rivailler
Pierre
P
Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Jiang
Hua
H
Cho
Young-gyu
YG
Quink
Carol
C
Wang
Fred
F
D000818:Animals; D001483:Base Sequence; D016679:Genome, Viral; D018143:Lymphocryptovirus / Q000235:genetics*; D008253:Macaca mulatta; D016366:Open Reading Frames; D017385:Sequence Homology; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins