title: PharmGKB: the Pharmacogenetics Knowledge Base.
abstract: The Pharmacogenetics Knowledge Base (PharmGKB; http://www.pharmgkb.org/) contains genomic, phenotype and clinical information collected from ongoing pharmacogenetic studies. Tools to browse, query, download, submit, edit and process the information are available to registered research network members. A subset of the tools is publicly available. PharmGKB currently contains over 150 genes under study, 14 Coriell populations and a large ontology of pharmacogenetics concepts. The pharmacogenetic concepts and the experimental data are interconnected by a set of relations to form a knowledge base of information for pharmacogenetic researchers. The information in PharmGKB, and its associated tools for processing that information, are tailored for leading-edge pharmacogenetics research. The PharmGKB project was initiated in April 2000 and the first version of the knowledge base went online in February 2001.
authors.affiliation: Stanford Medical Informatics, 251 Campus Drive, MSOB X-215, Stanford, CA 94305-5479, USA. hewett@smi.stanford.edu
authors.forename: Micheal
authors.initials: M
authors.lastname: Hewett
authors.forename: Diane E
authors.initials: DE
authors.lastname: Oliver
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Rubin
authors.forename: Katrina L
authors.initials: KL
authors.lastname: Easton
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Stuart
authors.forename: Russ B
authors.initials: RB
authors.lastname: Altman
authors.forename: Teri E
authors.initials: TE
authors.lastname: Klein
mesh_terms: D001711:Biotransformation / Q000235:genetics*; D003628:Database Management Systems; D016208:Databases, Factual; D004358:Drug Therapy; D004798:Enzymes / Q000378:metabolism; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010597:Pharmacogenetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D014584:User-Computer Interface
chemical_list: D004798:Enzymes; D004364:Pharmaceutical Preparations