Lipase/palladium-catalyzed asymmetric transformations of ketoximes to optically active amines.
[reaction: see text] Prochiral ketoximes were asymmetrically transformed to optically active amines in the acetylated forms by coupled lipase/palladium catalysis in the presence of an acyl donor under 1 atm of hydrogen.
Choi
Y K
YK
National Research Laboratory of Chirotechnology, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31 Hyojadong, Pohang, Kyungbuk 790-784, Korea.
Kim
M J
MJ
Ahn
Y
Y
Kim
M J
MJ
D000588:Amines / Q000737:chemistry*; D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D007659:Ketones / Q000737:chemistry*; D008049:Lipase / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D009904:Optical Rotation; D010091:Oximes / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000588:Amines; D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D007659:Ketones; D010091:Oximes; D010165:Palladium; C093667:Novozyme 435; D008049:Lipase; C431349:lipase B, Candida antarctica