title: [Inhibitors of absorption as anti-obesity drugs].
abstract: There are two types of anti-obesity agents which are classified as inhibitors of absorption: inhibitors of lipid and carbohydrate absorption. Inhibitors of lipid absorption consist of lipase inhibitor (orlistat, Nomma Herb's extract (CT-II) and fat substitute (olestra, sucrose polyester). Orlistat is now available as an anti-obesity drug in the USA and Europe. CT-II may be useful as a functional diet. Application of fat substitute is still limited in snack food. As for inhibitors of carbohydrate absorption, alpha-glucosidase inhibitors are now available as anti-diabetic drugs. To develop these agents for anti-obesity drug, solution of adverse effects on the gastrointestinal tract are necessary.
authors.affiliation: First Department of Internal Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8662, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tsuji
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Inoue
mesh_terms: D050260:Carbohydrate Metabolism; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007783:Lactones / Q000627:therapeutic use; D050356:Lipid Metabolism; D009765:Obesity / Q000188:drug therapy*; D000077403:Orlistat
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D007783:Lactones; D000077403:Orlistat