title: Noninvasive detection of endothelial dysfunction in elderly with NIDDM by ultrasonography.
abstract: We compared endothelial function noninvasively in 15 elderly patients with noninsulin-dependent diabetes mellitus (NIDDM) with 12 nondiabetic elderly patients. Using high resolution ultrasound, we measured flow-mediated dilatation (FMD) of the brachial artery and sublingual nitroglycerin (NTG)-mediated dilatation. FMD was significantly impaired in subjects with NIDDM compared with control subjects. In NIDDM subjects, FMD with complications was lower than in subjects with noncomplications. However, there was no significant difference in NTG between NIDDM subjects and the control group. Hyperemic blood flow change was lower in NIDDM subjects, but not significant. These results suggest that elderly patients with NIDDM have impaired L-arginine/nitric oxide (NO) pathways and the possibility of capillary rarefaction.
authors.affiliation: Department of Geriatric Medicine, Kanazawa Medical University, Uchinada-machi, Kahoku-gun, Ishikawa-ken 920-0293, Japan. gerontol@kanazawa-med.ac.jp.
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: E
authors.initials: E
authors.lastname: Miyauchi
authors.forename: Y B
authors.initials: YB
authors.lastname: Deng
authors.forename: K
authors.initials: K
authors.lastname: Iwai
authors.forename: H
authors.initials: H
authors.lastname: Hattori
mesh_terms: D000286:Administration, Sublingual; D000368:Aged; D000375:Aging / Q000502:physiology; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000209:etiology; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging*; D004727:Endothelium / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology*; D011336:Probability; D012016:Reference Values; D012044:Regression Analysis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D018608:Ultrasonography, Doppler / Q000379:methods*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D005996:Nitroglycerin