Functional methods for quantifying agonists and antagonists.
The development of occupancy theory has allowed the formulation of a series of mathematical models that describe the interaction of agonists and antagonists with their receptors, in terms of affinity and efficacy. These models provide a framework for the analysis and interpretation of E/[A] curve data and have proved to be useful tools in quantitative pharmacology. Unfortunately, despite the proven utility of this approach and the widespread availability of powerful computer-based curve-fitting programs [BMDP (41), Microsoft Excel. etc.], which greatly facilitate analysis, the application of mathematical modeling remains the exception rather than the rule in pharmacological studies.
Dougall
L G
LG
Astra Charnwood, Loughborough, Leicestershire, England.
D000818:Animals; D001665:Binding Sites; D004336:Drug Antagonism; D006801:Humans; D008962:Models, Theoretical; D010600:Pharmacology / Q000379:methods*; D011955:Receptors, Drug / Q000819:agonists* / Q000037:antagonists & inhibitors*
D011955:Receptors, Drug