Mesenchymal cell transfer for articular cartilage repair.
Mature articular cartilage has a poor reparative response to injury and its irreparable breakdown is the common feature of degenerative joint diseases. If articular cartilage lesions become symptomatic, the orthopaedic surgeon must decide on a treatment option. The treatment options include conversion of chondral lesions to osteochondral lesions, which facilitates migration of cells from the marrow space to effect repair. In recent years, a greater emphasis has been placed on tissue engineering strategies and thus several new treatment options have been introduced, including the use of cell transplantation. Several tissue sources and cell types can potentially be used for this type of therapy. These include autologous or allograft chondrocytes and mesenchymal progenitor cells from various tissues. These cells may be delivered to articular cartilage lesions by a variety of methods including direct cell injection to the lesion or seeding in a biodegradable scaffold prior to implantation. In this review, the potential of cell transplantation for articular cartilage repair and regeneration will be discussed. The authors will focus on the available technologies and the present limitations of cell-based therapies.
Johnstone
B
B
Department of Orthopaedics, Case Western Reserve University, Cleveland, OH 44106, USA. bxj9@po.cwru.edu
Yoo
J
J
D002358:Cartilage, Articular / Q000166:cytology* / Q000502:physiology; D017690:Cell Transplantation; D008648:Mesoderm / Q000166:cytology*; D012038:Regeneration