Danggui shaoyao san improve colchichine-induced learning acquisition impairment in rats.
OBJECTIVE
To investigate the effects of the water extracts of Danggui Shaoyao San (DGSYS) in rats used the passive avoidance task.


METHODS
Impairment in learning acquisition in rats was induced by colchicines, and the level of superoxide dismutase in the brain and the effects of DGSYS on the locomotor activity and pain threshold induced by colchicines were detected.


RESULTS
DGSYS (0.1-1.0 g/kg) attenuated the impairment of learning acquisition induced by colchicine (15 microg) and DGSYS (0.5 and 1.0 g/kg) increased the level of SOD (141 +/- 3 and 135.4 +/- 2.0) in the brain. However, DGSYS (0.1 - 1.0 g/kg) did not affect the locomotor activity and pain threshold in the rats treated with colchicines.


CONCLUSIONS
DGSYS can improve the learning acquisition deficit induced by colchicine in rats. The action mechanism of DGSYS may be involved in the increase in the level of superoxide dismutase.
Lu
M C
MC
Post-Baccalaureate School of Chinese Medicine, China Medical College, No 91, Hsueh Shih Road, Taichung, Taiwan, China.
D029971:Angelica sinensis; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D003078:Colchicine; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D007859:Learning Disabilities / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; C044613:angelicae sinensis extract; D013482:Superoxide Dismutase; D003078:Colchicine