C3stau, a new member of the family of C3-like ADP-ribosyltransferases.
C3-like ADP-ribosyltransferases, which are produced by Clostridium botulinum, Clostridium limosum, Bacillus cereus and Staphylococcus aureus, are exoenzymes lacking a translocation unit. These enzymes specifically inactivate Rho GTPases in host target cells. Recently, a novel C3-like transferase from S. aureus with new properties was identified, raising questions regarding its function. As Rho GTPases are master regulators of several eukaryotic signal processes and S. aureus can invade eukaryotic cells, C3 might play a role as a virulence factor.
Wilde
Christian
C
Institute of Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University Freiburg, Otto-Krayer-Haus, Albertstr. 25, Freiburg, Germany.
Chhatwal
Gursharan S
GS
Aktories
Klaus
K
D006367:HeLa Cells; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D013211:Staphylococcus aureus / Q000201:enzymology*; D020742:rhoA GTP-Binding Protein / Q000037:antagonists & inhibitors
D011065:Poly(ADP-ribose) Polymerases; D020742:rhoA GTP-Binding Protein