Myosin VI, a new force in clathrin mediated endocytosis.
The integrity of the actin cytoskeleton and associated motor proteins are essential for the efficient functioning of clathrin mediated endocytosis at least in polarised cells. Myosin VI, the only motor protein so far identified that moves towards the minus end of actin filaments, is the first motor protein to be shown to associate with clathrin coated pits/vesicles at the plasma membrane and to modulate clathrin mediated endocytosis. Recent kinetic studies suggest that myosin VI may move processively along actin filaments providing clues about its functions in the cell. The possible role(s) of myosin VI in the sequential steps involved in receptor mediated endocytosis are discussed.
Buss
F
F
Department of Clinical Biochemistry, University of Cambridge, UK. fb1@mole.bio.cam.ac.uk
Luzio
J P
JP
Kendrick-Jones
J
J
D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D016764:Cell Polarity; D002966:Clathrin / Q000502:physiology*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D020409:Molecular Motor Proteins / Q000737:chemistry / Q000502:physiology*; D018995:Myosin Heavy Chains / Q000737:chemistry / Q000502:physiology*; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000378:metabolism
D002966:Clathrin; D020409:Molecular Motor Proteins; D011956:Receptors, Cell Surface; C089785:myosin VI; D018995:Myosin Heavy Chains