In vitro activity of the chelating agents nitroxoline and oxine against Mycobacterium bovis BCG.
The chelating antibiotic nitroxoline (5-nitro-8-hydroxyquinoline) showed a bacteriostatic effect at a concentration of 10 microM for Mycobacterium bovis BCG. At higher concentrations the compound showed moderate cidal activity against growing bacilli. In contrast, its non-nitrated derivative oxine (8-hydroxyquinoline, MIC=2 microM) reduced the viability of a growing culture rapidly, 5000-fold at a concentration where the nitroxoline was merely bacteriostatic. Both compounds showed appreciable cidal activity against bacilli in their hypoxic dormant state.
Murugasu-Oei
B
B
Mycobacterium Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, 117609, Singapore, Singapore.
Dick
T
T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D002417:Cattle; D008826:Microbial Sensitivity Tests; D009163:Mycobacterium bovis / Q000187:drug effects*; D009600:Nitroquinolines / Q000494:pharmacology*; D015125:Oxyquinoline / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D009600:Nitroquinolines; D015125:Oxyquinoline; C005308:nitroxoline