title: Artelastocarpin and carpelastofuran, two new flavones, and cytotoxicities of prenyl flavonoids from Artocarpus elasticus against three cancer cell lines.
abstract: Further study of one of the fractions from the wood of Artocarpus elasticus furnished two new prenylated flavonoids artelastocarpin and carpelastofuran as well as ethyl 2,4-dihydroxybenzoate. The two flavonoids and the prenylated flavonoids artelastin, artelastochromene, artelasticin, artocarpesin, and cyclocommunin isolated earlier from this species were tested for cytotoxicity in vitro against three human cell lines. All seven flavonoids were active, the cytotoxic effect varying from strong to moderate and with artelastin showing the most potent activity.
authors.forename: H M
authors.initials: HM
authors.lastname: Cidade
authors.forename: M S
authors.initials: MS
authors.lastname: Nacimento
authors.forename: M M
authors.initials: MM
authors.lastname: Pinto
authors.forename: A
authors.initials: A
authors.lastname: Kijjoa
authors.forename: A M
authors.initials: AM
authors.lastname: Silva
authors.forename: W
authors.initials: W
authors.lastname: Herz
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry / Q000494:pharmacology; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology; D029586:Moraceae; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009387:Neoprene / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018547:Plant Stems / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D062385:Hydroxybenzoates; C452807:artelastocarpin; C452808:carpelastofuran; C452809:ethyl 2,4-dihydroxybenzoate; C016077:prenyl; D009387:Neoprene