Anti-thrombosis effect of paeoniflorin: evaluated in a photochemical reaction thrombosis model in vivo.
In a photochemical reaction microvessel thrombosis model, the anti-thrombotic effect of PT was evaluated and the results showed that PF could significantly prolong thromobosis time. The anti-thrombotic effect of PF may relate to the inhibition of arachidonic acid metabolism, the increase of t-PA activity, and the protective effect against free radical.
Ye
J
J
Department of Biomedical Engineering, Zhejiang University, Hangzhou City, China.
Duan
H
H
Yang
X
X
Yan
W
W
Zheng
X
X
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001565:Benzoates; D001952:Bridged-Ring Compounds; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use*; D005609:Free Radicals; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D039821:Monoterpenes; D029596:Paeonia / Q000737:chemistry*; D010777:Photochemistry; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013927:Thrombosis / Q000188:drug therapy*; D006027:Glycosides
D016718:Arachidonic Acid; D001565:Benzoates; D001952:Bridged-Ring Compounds; D005343:Fibrinolytic Agents; D016166:Free Radical Scavengers; D005609:Free Radicals; D005960:Glucosides; D039821:Monoterpenes; D028321:Plant Preparations; C015423:peoniflorin; D006027:Glycosides