Enzyme-activated targeting of liposomes.
It has become increasingly evident that tissues utilize specific localization of enzymes to perform certain tasks, often associated with various types of tissue remodeling. The ubiquitous presence of such enzymes, along with their specific localizations, provides an ideal opportunity to elicit specific delivery via an enzyme-triggered mechanism. A survey of some of the recent progress in enzyme-activated targeting of delivery systems, with a focus on a few liposomal systems, is presented.
Meers
P
P
Elan Pharmaceutical Technologies (formerly The Liposome Company), 1 Research Way, Princeton, NJ 08540, USA. pmeers@elancorp.com
D000818:Animals; D004337:Drug Carriers; D004789:Enzyme Activation / Q000502:physiology*; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D008081:Liposomes; D010196:Pancreatic Elastase / Q000737:chemistry
D004337:Drug Carriers; D004798:Enzymes; D008081:Liposomes; D010196:Pancreatic Elastase