Vascular architecture of normal human urinary bladder and its remodeling in cancer, as revealed by corrosion casting.
The vasculature of normal human urinary bladder wall and its tumors were studied using corrosion casting and scanning electron microscopy. In the normal wall, a regular organization of highly tortuous horizontal and vertical vessels allows accommodation of the vascular system to spatial changes resulting from the filling/voiding cycle. The vasculature of tumors is a result of remodeling of preexisting wall vessels associated with gradual growth of the neoplastic tissue. The shape and arrangement of blood vessels in different regions of the tumor seem to reflect a variable dynamics of tumor development and possible influence of various angiogenesis-promoting growth factors.
Miodonski
A J
AJ
Department of Histology, Jagiellonian University School of Medicine, Kraków, Poland. mmlitwin@cyf-kr.edu.pl
Litwin
J A
JA
Nowogrodzka-Zagórska
M
M
Gorczyca
J
J
D001808:Blood Vessels / Q000473:pathology* / Q000648:ultrastructure*; D002454:Cell Differentiation / Q000502:physiology*; D016319:Corrosion Casting / Q000379:methods*; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic / Q000473:pathology*; D001743:Urinary Bladder / Q000098:blood supply* / Q000473:pathology / Q000648:ultrastructure*; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000648:ultrastructure*