title: D-amphetamine does not improve outcome of somatosensory training.
abstract: BACKGROUND
  D-amphetamine has been shown to affect early stages of stroke recovery, and may have a beneficial effect on functions when administered later after stroke.
  
  
  OBJECTIVE
  To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated.
  
  
  METHODS
  Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design.
  
  
  RESULTS
  All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine.
  
  
  CONCLUSIONS
  No beneficial effect of D-amphetamine on somatosensory training improvements was found in healthy subjects.
authors.affiliation: Department of Neurology, University of Münster, Germany. knecht@uni-muenster.de
authors.forename: S
authors.initials: S
authors.lastname: Knecht
authors.forename: T
authors.initials: T
authors.lastname: Imai
authors.forename: S
authors.initials: S
authors.lastname: Kamping
authors.forename: C
authors.initials: C
authors.lastname: Breitenstein
authors.forename: H
authors.initials: H
authors.lastname: Henningsen
authors.forename: B
authors.initials: B
authors.lastname: Lütkenhöner
authors.forename: E B
authors.initials: EB
authors.lastname: Ringelstein
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003913:Dextroamphetamine / Q000008:administration & dosage*; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D010812:Physical Stimulation; D020521:Stroke / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D003913:Dextroamphetamine