title: Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia.
abstract: To investigate the functional role of Ca(v)2.3 channel in glucose homeostasis, we performed in vivo glucose tolerance and insulin tolerance tests together with stress-induced glucose release tests using mice deficient in Ca(v)2.3 channel (Ca(v)2.3-/-). The Ca(v)2.3-/- mice were significantly heavier than wild-type mice. In glucose tolerance and insulin tolerance tests, Ca(v)2.3-/- mice showed a significantly higher blood glucose level compared to wild-type mice. However, stress-induced blood glucose changes in Ca(v)2.3-/- mice were similar to those in wild-type mice. These results suggest that Ca(v)2.3 channel plays a role in glucose homeostasis by reducing insulin sensitivity and that Ca(v)2.3-/- mice exhibit symptoms resembling non-insulin-dependent diabetes mellitus.
authors.affiliation: Department of Pharmacology and Neurobiology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Saegusa
authors.forename: S
authors.initials: S
authors.lastname: Zong
authors.forename: T
authors.initials: T
authors.lastname: Noda
authors.forename: T
authors.initials: T
authors.lastname: Tanabe
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D015220:Calcium Channels / Q000172:deficiency* / Q000235:genetics* / Q000378:metabolism; D020908:Calcium Channels, R-Type; D027682:Cation Transport Proteins; D003080:Cold Temperature / Q000009:adverse effects; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006943:Hyperglycemia / Q000209:etiology* / Q000378:metabolism*; D007103:Immobilization / Q000009:adverse effects; D007328:Insulin / Q000008:administration & dosage / Q000097:blood; D051379:Mice; D018345:Mice, Knockout; D013312:Stress, Physiological / Q000097:blood
chemical_list: D001786:Blood Glucose; C498916:Cacna1e protein, mouse; D015220:Calcium Channels; D020908:Calcium Channels, R-Type; D027682:Cation Transport Proteins; D007328:Insulin