title: DNA cleavage by pentadentate iron(II) complexes containing fluoro-substituted phenyl groups.
abstract: Four pentadentate iron(II) complexes containing non- or fluoro-substituted phenyl group (2b-2e) were synthesized and cleaving activity of them to pUC19 DNA was evaluated in the presence of hydrogen peroxide. DNA cleavage activity increased with the number of substituted fluorine atoms on the phenyl group of 2b.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kurosaki
authors.forename: Aoi
authors.initials: A
authors.lastname: Maruyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koike
authors.forename: Naoko
authors.initials: N
authors.lastname: Kuroda
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Masafumi
authors.initials: M
authors.lastname: Goto
mesh_terms: D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D004578:Electron Spin Resonance Spectroscopy; D004587:Electrophoresis, Agar Gel; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology*; D005461:Fluorine / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry
chemical_list: D005296:Ferrous Compounds; D005461:Fluorine; D004247:DNA; D006861:Hydrogen Peroxide