Anaphylaxis to gelatin-containing rectal suppositories.
BACKGROUND
Some children--though the number is few-have been sensitized with gelatin.


OBJECTIVE
To investigate the relationship between the presence of antigelatin IgE and anaphylaxis to gelatin-containing rectal suppository, we measured antigelatin IgE in the sera of the children with anaphylaxis.


METHODS
Ten children showed systemic allergic reactions, including anaphylaxis, to a chloral hydrate rectal suppository containing gelatin (231 mg/dose) that had been used as a sedative. These children's clinical histories and serum samples were submitted from physicians to the National Institute of Infectious Diseases during a 2-year period from 1996 to 1997.


RESULTS
Of the 10 children, 5 showed apparent anaphylaxis, including hypotension and/or cyanosis, along with urticaria or wheezing; 2 showed both urticaria and wheezing without hypotension or cyanosis; the other 3 showed only urticaria. All of the children had antigelatin IgE (mean value +/- SD, 7.9 +/- 8.4 Ua/mL). As a control, samples from 250 randomly selected children had no antigelatin IgE. These findings suggest that the 10 children's systemic allergic reactions to this suppository were caused by the gelatin component.


CONCLUSIONS
Gelatin-containing suppositories must be used with the same caution as gelatin-containing vaccines and other medications.
Sakaguchi
M
M
Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
Inouye
S
S
D000707:Anaphylaxis / Q000209:etiology*; D002675:Child, Preschool; D005260:Female; D005780:Gelatin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D013488:Suppositories / Q000009:adverse effects*
D013488:Suppositories; D005780:Gelatin