title: Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine.
abstract: The electrically elicited corneal reflex is a useful tool for exploring the trigeminal system in humans and it may provide additional evidence pointing to a dysfunction of this system in migrainous patients. Tactile perception, corneal reflex and pain thresholds were studied in 48 migraine without aura patients during pain-free periods and compared with those observed in 24 controls. Twenty-eight of the patients had strictly unilateral headache, while the other 20 had bilateral or side-shifting pain during attacks. Both migraine subgroups (bilateral and unilateral) showed significantly lower thresholds compared with controls. The lowest values were observed on the symptomatic side of unilateral migraine patients. These findings suggest that sensorimotor mechanisms and/or pain control systems at the trigeminal level are impaired in migraine. The bilateral location of these abnormalities seems to point to a centrally located dysfunction.
authors.affiliation: Laboratory of Pain Psychophysiology, Department of Neurological Sciences, University Center for Adaptive Disorders and Headache, University of Pavia, Via Palestro 3, 27100 Pavia, Italy. gsandrin@unipv.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sandrini
authors.forename: Alberto
authors.initials: A
authors.lastname: Proietti Cecchini
authors.forename: Ivan
authors.initials: I
authors.lastname: Milanov
authors.forename: Cristina
authors.initials: C
authors.lastname: Tassorelli
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Buzzi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nappi
mesh_terms: D000328:Adult; D001767:Blinking / Q000502:physiology*; D002536:Cerebral Arteries / Q000294:innervation / Q000503:physiopathology; D004558:Electric Stimulation; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000473:pathology / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D009475:Neurons, Afferent / Q000502:physiology*; D017288:Pain Threshold / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D014276:Trigeminal Nerve / Q000473:pathology / Q000503:physiopathology*