The related murine kinases, Nek6 and Nek7, display distinct patterns of expression.
Nek6 and Nek7 are evolutionarily conserved murine kinases structurally related to the Aspergillus mitotic-regulator NIMA (Genomics 68 (2000) 187). Comparative in situ examination of their patterns of expression revealed that during early embryogenesis nek6 is highly expressed in primary giant trophoblast cells, while nek7 is expressed in the site of decidual reaction. Later in embryogenesis, both RNAs are almost exclusively restricted to the nervous system. nek6 is found in ventricular and sub-ventricular regions, while nek7 is highly expressed in the dorsal thalamus. In the adult brain, distinct nuclei express the two genes. The lineage- and tissue-specific patterns of expression suggest that the two NIMA-related kinases have (additional) functions that are not related to the mitotic functions of NIMA.
Feige
Erez
E
Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Motro
Benny
B
D000818:Animals; D003656:Decidua / Q000196:embryology / Q000201:enzymology; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D051379:Mice; D000072379:NIMA-Related Kinases; D009420:Nervous System / Q000196:embryology / Q000201:enzymology / Q000254:growth & development; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014327:Trophoblasts / Q000201:enzymology
D012333:RNA, Messenger; D000072379:NIMA-Related Kinases; C442331:NIMA-related kinase 6; C512686:Nek7 protein, mouse; D017346:Protein Serine-Threonine Kinases