Behavioral and neurochemical effects of 3-OH-pip-BTCP, an active metabolite of BTCP in rats.
The effects of N-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidin-3-ol (3-OH-pip-BTCP), an active metabolite of N-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP) was examined on locomotor activity and dopamine (DA) levels in the nucleus accumbens (NAcc) in rats. To study the stimulant action of 3-OH-pip-BTCP, rats were placed into activity chambers and injected with the compound (0-40 mg/kg, i.p.). To measure the effects of 3-OH-pip-BTCP on DA levels, rats were implanted with microdialysis probes into the NAcc and the same doses as used in the locomotor activity experiment were administered i.p. 3-OH-pip-BTCP dose-dependently increased locomotor activity and DA levels in the NAcc which lasted 4-5 h at 20 and 40 mg/kg. The results suggest that 3-OH-pip-BTCP exerts long lasting stimulating effects on locomotion and extracellular DA levels in the NAcc, suggesting that 3-OH-pip-BTCP contributes importantly to the pharmacological effects of its parent compound, BTCP.
Martin-Fardon
R
R
The Scripps Research Institute, Department of Neuropharmacology CVN-15, 10550 North Torrey Pines Road, La Jolla CA 92037, USA.
Kerr
T M
TM
Deleuze-Masquefa
C
C
Kamenka
J M
JM
Weiss
F
F
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology; D018491:Dopamine Agonists / Q000493:pharmacokinetics*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D017551:Microdialysis; D009043:Motor Activity / Q000187:drug effects*; D010622:Phencyclidine / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018491:Dopamine Agonists; D018765:Dopamine Uptake Inhibitors; C447408:N-(1-(2-benzo(b)thiophenyl)cyclohexyl)piperidin-3-ol; C056415:1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidine; D003042:Cocaine; D010622:Phencyclidine