title: Dynamics of NADPH diaphorase activity in raphe neurons during chronic treatment with opiates.
abstract: Systemic administration of diacetylmorphine considerably reduced the number of NADPH diaphorase-positive (NO-synthesizing) neurons in rat brain raphe nuclei. This effect was blocked by naloxone. In animals with the withdrawal syndrome NO-ergic activity in raphe neurons increased and surpassed the normal.
authors.affiliation: Laboratory of Pharmacology, Institute of Sea Biology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok. iduizen@yahoo.com
authors.forename: I V
authors.initials: IV
authors.lastname: Dyuizen
authors.forename: P A
authors.initials: PA
authors.lastname: Motavkin
authors.forename: V V
authors.initials: VV
authors.lastname: Shorin
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002467:Cell Nucleus / Q000201:enzymology / Q000378:metabolism; D003932:Heroin / Q000378:metabolism / Q000494:pharmacology; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D009474:Neurons / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D011903:Raphe Nuclei / Q000201:enzymology / Q000378:metabolism*; D051381:Rats
chemical_list: D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D009294:Narcotics; D009569:Nitric Oxide; D009270:Naloxone; D003932:Heroin; D009252:NADPH Dehydrogenase