Treatment of rhinocerebral mucormycosis by combination of endoscopic sinus debridement and amphotericin B.
Rhinocerebral mucormycosis (RCM) is an aggressive fungal infection with a high mortality rate. It frequently develops in patients with uncontrolled diabetes mellitus or immunocompromised patients. RCM typically presents in a rapidly fulminant manner with headache, fever, mucosal necrosis, and ophthalmic symptoms. Although the definitive diagnosis is achieved by histopathological examination, computed tomography (CT) scanning and magnetic resonance (MR) are the best imaging procedures in early diagnosis to assess the extent of the disease.
Alobid
I
I
Department of Otorhinolaryngology, Hospital Clinic of Barcelona, Spain.
Bernal
M
M
Calvo
C
C
Vilaseca
I
I
Berenguer
J
J
Alós
L
L
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001927:Brain Diseases / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D003646:Debridement / Q000379:methods; D004724:Endoscopy; D006801:Humans; D018810:Magnetic Resonance Angiography; D009091:Mucormycosis / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010254:Paranasal Sinus Diseases / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000628:therapy*; D014057:Tomography, X-Ray Computed
D000935:Antifungal Agents; D000666:Amphotericin B