Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum.
Genotypic analysis of herpes simplex virus (HSV) DNA extracted from clinical specimens from a case of fatal disseminated neonatal HSV demonstrated that an infant developed an acyclovir-resistant HSV containing a mutation in the HSV thymidine kinase gene during the first seven days of acyclovir therapy.
Levin
M J
MJ
Section of Infectious Diseases Department of Pediatrics University of Colorado School of Medicine Denver, CO, USA.
Weinberg
A
A
Leary
J J
JJ
Sarisky
R T
RT
D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001344:Autopsy; D004279:DNA, Viral / Q000032:analysis / Q000737:chemistry; D024882:Drug Resistance, Viral; D017809:Fatal Outcome; D005260:Female; D017245:Foscarnet / Q000494:pharmacology / Q000627:therapeutic use; D005838:Genotype; D006561:Herpes Simplex / Q000188:drug therapy* / Q000635:transmission; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008826:Microbial Sensitivity Tests; D009154:Mutation; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D018139:Simplexvirus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013937:Thymidine Kinase / Q000235:genetics
D000998:Antiviral Agents; D004279:DNA, Viral; D017245:Foscarnet; D013937:Thymidine Kinase; D000212:Acyclovir