Ethical considerations in cluster headache research.
Cluster headache is the most painful of the primary headache disorders and elucidating pathophysiology and treatment for this disorder is crucial. There is justification for studying attacks untreated, and even for precipitating these attacks. Placebo-controlled studies should only be undertaken for regulatory purposes; otherwise, active control should be used.
Tepper
Stewart J
SJ
The New England Center for Headache, 778 Long Ridge Road, Stamford, CT 06902, USA. sjtepper@aol.com
Rapoport
Alan M
AM
Sheftell
Fred D
FD
D003027:Cluster Headache / Q000503:physiopathology / Q000628:therapy*; D026690:Ethics, Clinical; D006801:Humans; D012106:Research