title: PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection.
authors.affiliation: Division of Immunology and Organ Transplantation, University of Texas-Houston, Houston, Texas, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Stepkowski
authors.forename: Z S
authors.initials: ZS
authors.lastname: Nagy
authors.forename: M E
authors.initials: ME
authors.lastname: Wang
authors.forename: F
authors.initials: F
authors.lastname: Behbod
authors.forename: R
authors.initials: R
authors.lastname: Erwin-Cohen
authors.forename: B D
authors.initials: BD
authors.lastname: Kahan
authors.forename: R A
authors.initials: RA
authors.lastname: Kirken
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D053616:Janus Kinase 3; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011758:Pyrroles / Q000627:therapeutic use*; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: C119625:4-benzyloxy-5-((5-undecyl-2H-pyrrol-2-ylidene)methyl)-2,2'-bi-1H-pyrrole; D007166:Immunosuppressive Agents; C507936:Jak3 protein, rat; D011758:Pyrroles; D011505:Protein-Tyrosine Kinases; C507933:JAK3 protein, human; D053616:Janus Kinase 3; D011353:Prodigiosin