title: Mental and motor switching in Parkinson's disease.
abstract: Switching difficulties in Parkinson's disease (PD) are expressed in both mental and motor tasks. The authors of the present study investigated whether those deficits coexist in the same patient and are positively correlated. They tested 8 nondemented PD patients and 6 age-matched control participants by using the modified Wisconsin Card Sorting Test and a motor switching paradigm that is based on the task of reaching toward visual targets, the location of which could unexpectedly be altered within the reaction time. In both mental and motor tasks, patients performed significantly worse than controls. There were no significant correlations between the two types of pathology in individual patients. Mental and motor switching deteriorate in PD patients, but the deficits are not necessarily of parallel severity.
authors.affiliation: Department of Applied Mathematics and Computer Science, The Weizmann Institute of Science, Rehovot, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Inzelberg
authors.forename: M
authors.initials: M
authors.lastname: Plotnik
authors.forename: T
authors.initials: T
authors.lastname: Flash
authors.forename: E
authors.initials: E
authors.lastname: Schechtman
authors.forename: I
authors.initials: I
authors.lastname: Shahar
authors.forename: A D
authors.initials: AD
authors.lastname: Korczyn
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001288:Attention / Q000502:physiology; D001479:Basal Ganglia / Q000503:physiopathology; D004193:Discrimination Learning / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology*; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology