Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear.
We studied the natural course of high-risk human papillomavirus (HPV) infection and cytological regression in women referred for colposcopy because of abnormal cervical smears. We found that high-risk HPV clearance preceded regression of cervical lesions by an average of 3 months. The cumulative 1-year rate of cytological regression was similar in women with mild and moderate dyskaryotic cervical smears. Thus, retesting of high-risk HPV after 6 months in women with mild to moderate dyskaryosis predicts cytological regression.
Nobbenhuis
M A
MA
Helmerhorst
T J
TJ
van den Brule
A J
AJ
Rozendaal
L
L
Voorhorst
F J
FJ
Bezemer
P D
PD
Verheijen
R H
RH
Meijer
C J
CJ
D000328:Adult; D003127:Colposcopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D013997:Time Factors; D014626:Vaginal Smears