Low-density lipoprotein-antioxidant constituents of Saururus chinensis.
A new diarylbutane lignan, saururin A (1), and a known 8-O-4'-type neolignan, machilin D (2), were isolated from a total methanol extract of the underground parts of Saururus chinensis. The structures of 1 and 2 were elucidated by spectroscopic data analysis. Compounds 1, 2, and virolin (3) (the methyl ether of 2) exhibited significant low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substance (TBARS) assay with IC(50) values of 8.5, 2.9, and 4.3 microM, respectively.
Ahn
B T
BT
Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong P.O. Box 115, Taejon 305-600, Korea.
Lee
S
S
Lee
S B
SB
Lee
E S
ES
Kim
J G
JG
Bok
S H
SH
Jeong
T S
TS
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D006801:Humans; D020128:Inhibitory Concentration 50; D007723:Korea; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000097:blood*; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D017705:Lignans; D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances; C446120:machilin D; C446119:saururin A; C446121:virolin