Association of CD4+/CD56+/CD57+/CD8+(dim) large granular lymphocytic leukemia, splenic B-cell lymphoma with circulating villous lymphocytes, and idiopathic erythrocytosis.
In this paper we report a rare association of a splenic marginal zone B-cell lymphoma with villous lymphocytes and a T-cell large granular lymphocytic leukemia coexpressing CD4 and CD8 as well as CD56 and CD57 natural killer-associated markers in an asymptomatic patient investigated because of an occasional finding of erythrocytosis and leukocytosis in routine blood analysis. We also discuss the possible reasons for this particular association.
Lima
M
M
Service of Clinical Hematology, Hospital Geral Santo António, Porto, Portugal. mmc.lima@clix.pt
Gonçalves
C
C
Marques
L
L
Martin
M C
MC
Teixeira
M A
MA
Queirós
M L
ML
Santos
A H
AH
Balanzategui
A
A
Garcia-Sanz
R
R
Pinto-Ribeiro
A C
AC
Justiça
B
B
Orfão
A
A
D000368:Aged; D001773:Blood Cells / Q000473:pathology; D015704:CD4 Antigens / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D018959:CD57 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D016130:Immunophenotyping; D015458:Leukemia, T-Cell / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D008214:Lymphocytes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D011086:Polycythemia / Q000150:complications*; D013154:Spleen / Q000473:pathology
D015704:CD4 Antigens; D019002:CD56 Antigen; D018959:CD57 Antigens; D016827:CD8 Antigens