title: Clinicopathologic characterization of squamous-cell carcinoma arising from pilonidal disease in association with condylomata acuminatum in HIV-infected patients: report of two cases.
abstract: Pilonidal disease is a common acquired condition believed to arise from penetration of short hairs into the subcutaneous tissue that induces a cyst or sinus formation. Malignant degeneration is rare and is typically seen only after decades of antecedent disease presence. Condylomata acuminatum in association with pilonidal disease have been described in two prior case reports, however, the coexistence of condyloma with pilonidal disease complicated by malignant degeneration has not been previously reported. Condylomata have known potential for malignant degeneration and are correlated with human papilloma virus infection, with certain serotypes of higher oncogenic potential. Coinfection with human immunodeficiency virus and human papilloma virus is associated with higher rates of anal neoplasia. We report two cases of human immunodeficiency virus-infected patients with the constellation of pilonidal disease, condylomata acuminatum, and subsequent malignant degeneration into squamous-cell carcinoma. In contrast to other case reports in the literature, these two patients had considerably shorter antecedent periods of pilonidal disease before malignant degeneration was detected. Both cases also had intractable courses. We conclude that the existence of condylomata acuminatum and pilonidal disease in an immunocompromised patient may represent a more ominous condition than solitary pilonidal disease. Therefore, careful inspection of the pilonidal area in human immunodeficiency virus-infected patients presenting with condylomata is important and earlier intervention should be considered. Moreover, further evaluation of the prevalence of squamous-cell carcinoma arising from pilonidal disease complicated by condylomata, particularly in the immunosuppressed, is warranted.
authors.affiliation: Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: V F
authors.initials: VF
authors.lastname: Borges
authors.forename: J T
authors.initials: JT
authors.lastname: Keating
authors.forename: I A
authors.initials: IA
authors.lastname: Nasser
authors.forename: T P
authors.initials: TP
authors.lastname: Cooley
authors.forename: H L
authors.initials: HL
authors.lastname: Greenberg
authors.forename: B J
authors.initials: BJ
authors.lastname: Dezube
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology*; D003218:Condylomata Acuminata / Q000150:complications*; D004279:DNA, Viral / Q000032:analysis; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D010864:Pilonidal Sinus / Q000150:complications / Q000473:pathology*; D016133:Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*
chemical_list: D004279:DNA, Viral