Inhibition of regrowth of prostatic glandular cells by epristeride.
OBJECTIVE
To evaluate the ability of epristeride to inhibit the prostatic glandular regrowth.


METHODS
Normal rats were castrated. Testosterone was injected to induce the regrowth of glandular cells. HE staining was performed. The height of the glandular epithelium and the acinar luminal areas were determined, and dihydrotestosterone (DHT) was detected by immunohistochemistry.


RESULTS
Both the height and the acinar luminal areas were reduced by 48 % and 55 % in epristeride-treated group compared with control group respectively. The staining of DHT was comparatively strong in the control group. After 30-d of treatment, it turned much weaker.


CONCLUSIONS
The regrowth of glandular cells was inhibited by epristeride via declining of the DHT concentration in the rat prostate.
Qian
L H
LH
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Wang
X L
XL
Tu
Z H
ZH
D058891:5-alpha Reductase Inhibitors; D000730:Androstadienes / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D013196:Dihydrotestosterone / Q000032:analysis; D004847:Epithelial Cells / Q000378:metabolism; D008297:Male; D009919:Orchiectomy; D011467:Prostate / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000494:pharmacology
D058891:5-alpha Reductase Inhibitors; D000730:Androstadienes; D013196:Dihydrotestosterone; C072547:epristeride; D013739:Testosterone