title: Gene dose effect of the APOE-epsilon4 allele on plasma HDL cholesterol level in patients with Alzheimer's disease.
abstract: It has been reported that decreased serum high density lipoprotein (HDL) cholesterol level is related with severity of Alzheimer's disease (AD). Here, 82 patients with AD and 40 non-demented individuals were examined to determine how the APOE-epsilon4 allele modifies plasma cholesterol fractions. In adjusting for age, sex and plasma albumin level, plasma HDL cholesterol level was inversely correlated with the APOE-epsilon4 dose only in the patients (P = 0.0048), while plasma low density lipoprotein (LDL) cholesterol level tended to be correlated with the APOE-epsilon4 dose in both groups, although this was not significant. The ratio of LDL to HDL cholesterol in the patients showed a similar correlation with the APOE-epsilon4 dose to that in the controls, and this correlation was evident (P = 0.0069) after putting all subjects into one group. However, neither HDL nor LDL cholesterol levels showed significant differences between the groups. These results indicated that the APOE-epsilon4 dose affects the composition of plasma cholesterol, and suggested that the genetic effect on plasma lipid metabolism could be distinctive in patients with AD.
authors.affiliation: Department of Geriatric Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-cho, Kahoku-gun, 920-0293, Ishikawa, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hoshino
authors.forename: Kouzin
authors.initials: K
authors.lastname: Kamino
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsumoto
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics / Q000502:physiology*; D000483:Alleles; D000544:Alzheimer Disease / Q000097:blood*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D018628:Gene Dosage; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D009747:Nutritional Physiological Phenomena; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D012709:Serum Albumin