Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity.
Resistance to innate immunity is essential for salmonellae pathogenesis. The salmonellae PhoP/PhoQ regulators sense host environments to promote remodeling of the bacterial envelope. This remodeling includes enzymes that modify lipopolysaccharide (LPS). Modified LPS promotes bacterial survival by increasing resistance to cationic antimicrobial peptides and by altered host recognition of LPS.
Ernst
R K
RK
University of Washington, Department of Medicine, HSB K-140, Box 357710, Seattle, WA 98195, USA.
Guina
T
T
Miller
S I
SI
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D007113:Immunity, Innate; D008070:Lipopolysaccharides / Q000378:metabolism*; D051379:Mice; D012480:Salmonella Infections / Q000382:microbiology; D012486:Salmonella typhimurium / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity*
D001426:Bacterial Proteins; D008070:Lipopolysaccharides; C079792:PhoQ protein, Bacteria; C061279:PhoR protein, Bacteria