Understanding chronic pelvic pain syndrome.
Patients with non-inflammatory chronic pelvic pain syndrome, the largest group of prostatitis patients according to the US National Institute of Diabetes and Digestive and Kidney Diseases classification, are characterized by the absence of objective findings. Nothing thus links the symptoms of this disease to the prostate or other male organs in particular. For this reason, observations on interstitial cystitis in women are of interest to understand the chronic pelvic pain syndrome. New information from studies on the inflammatory response in expressed prostatic secretion in patients with chronic pelvic pain syndrome and in bladder tissue from patients with interstitial cystitis indicates that complex systems on the cytokine gene expression level may be operating in these diseases. Research findings point to a common denominator at the level of molecular biology that might explain how the symptoms of chronic pelvic pain syndrome and interstitial cystitis can be precipitated by pathogens, inflammatory reactions and even neurological mechanisms. The initial clinical trial reports of drugs that modulate the inflammatory response in interstitial cystitis are met with great interest.
Bjerklund Johansen
Truls E
TE
Urology Section, Telemark Central Hospital, Porsgrunn, Norway. trulsebj@frisurf.no
Weidner
Wolfgang
W
D001190:Arylsulfonates / Q000627:therapeutic use; D018856:Cystitis, Interstitial / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D005260:Female; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000502:physiology; D020078:Neurogenic Inflammation / Q000150:complications / Q000276:immunology; D017699:Pelvic Pain / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D015990:Placebo Effect; D011472:Prostatitis / Q000150:complications / Q000188:drug therapy; D013452:Sulfonium Compounds / Q000627:therapeutic use; D013577:Syndrome
D001190:Arylsulfonates; D016207:Cytokines; D006633:Histamine Antagonists; D013452:Sulfonium Compounds; C073028:suplatast tosilate