title: Use of S-Mosher acid as a chiral solvating agent for enantiomeric analysis of some trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines by means of NMR spectroscopy.
abstract: S-Mosher acid 1 induced chemical-shift differences (Delta delta) in NMR spectra of chiral trans-4-fluorophenyl-3-substituted-1-methylpiperidines. The magnitude of Delta delta in (1)H and (19)F NMR spectra varied with the substituent at position 3 of the piperidine ring. The magnitudes of Delta delta observed for certain protons and for the fluorine in the 4-fluorophenyl group were sufficiently large to allow determination of enantiomeric composition.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic. hanavra@chemi.muni.cz
authors.forename: H
authors.initials: H
authors.lastname: Navrátilová