title: Continuous haemodynamic monitoring during withdrawal of diuretics in patients with congestive heart failure.
abstract: OBJECTIVE
  Right heart pressure parameters can be recorded continuously with the help of an implanted haemodynamic monitor. The aim of this study was to investigate the usefulness of the device in adjusting diuretic medication in patients with chronic congestive heart failure, and to evaluate the response of right ventricular pressure to increased volume load induced by diuretic withdrawal.
  
  
  RESULTS
  Four patients with stable congestive heart failure were implanted with an implantable haemodynamic monitor. Furosemide, the only diuretic used, was reduced by 50% the first week, withdrawn completely for the second week and then reinstituted in the initial dose. Right ventricular systolic and diastolic pressure, pulse pressure, dP/dt, estimated diastolic pulmonary artery pressure and heart rate were sampled continuously. Patients were evaluated by body weight, NYHA class, serum creatinine, serum brain natriuretic peptide, the 6 min walk test, quality of life and echocardiography on days 0, 7, 14 and 21. We observed significant changes in right ventricular pressure parameters in parallel with clinical signs and symptoms of worsening heart failure, such as increased body weight, a shorter walking distance and impaired quality of life. Moreover elevated levels of brain natriuretic peptide and lower creatinine levels were observed.
  
  
  CONCLUSIONS
  Haemodynamic changes due to increased volume load can be detected with an implantable haemodynamic monitor. Such data provide useful information for tailoring an optimal diuretic dose in patients with congestive heart failure.
authors.affiliation: Department of Cardiology, Karolinska Hospital, Stockholm, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Braunschweig
authors.forename: C
authors.initials: C
authors.lastname: Linde
authors.forename: M J
authors.initials: MJ
authors.lastname: Eriksson
authors.forename: C
authors.initials: C
authors.lastname: Hofman-Bang
authors.forename: L
authors.initials: L
authors.lastname: Rydén
mesh_terms: D000368:Aged; D004232:Diuretics / Q000627:therapeutic use*; D015150:Echocardiography, Doppler; D004869:Equipment Safety / Q000295:instrumentation; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis* / Q000188:drug therapy*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011788:Quality of Life / Q000523:psychology; D016278:Ventricular Function, Right / Q000502:physiology; D028761:Withholding Treatment
chemical_list: D004232:Diuretics; D020097:Natriuretic Peptide, Brain