title: Toxicity of moniliformin from Fusarium fujikuroi culture material to growing barrows.
abstract: In two studies, the effects of moniliformin (M)-contaminated diets from Fusarium fujikuroi culture material on growing barrows were evaluated. In the first study, six barrows (three replicates of two each, mean body weight = 17.8 kg) per group (four groups; 24 barrows total) were fed diets calculated to contain 0 mg M/kg feed (control); 25 mg M/kg feed; 50 mg M/kg feed; or 100 mg M/kg feed for 28 days. In the second study, the same experimental design and numbers of barrows (mean body weight = 15.3 kg) were used, and diets were formulated to contain 0 mg M/kg feed (control); 50 mg M/kg feed; 100 mg M/kg feed; or 200 mg M/kg feed. Diets of 100 mg or 200 mg M/kg feed reduced body weight, body weight gain, and feed consumption. Serum biochemical analytes were affected by 100 to 200 mg M/kg feed. Hematologic values were affected by 50, 100, and 200 mg M/kg feed. In the first study, one barrow in the 100 mg M-treated group died, and in the second study. one barrow died in the 100 mg M-treated group, and five barrows died in the 200 mg M-treated group. Relative heart weight was increased in the 200 mg M-treated barrows, yet tissues from organs collected from treatment groups were generally histologically unimpressive. The most consistent sign of M toxicity in barrows appeared to be death induced within 2 to 5 days by 100 to 200 mg M/kg feed.
authors.affiliation: Food and Feed Safety Research Unit, Agricultural Research Service, US Department of Agriculture, College Station 77845, USA. harvey@ffsru.tamu.edu
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
authors.forename: T S
authors.initials: TS
authors.lastname: Edrington
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
authors.forename: J R
authors.initials: JR
authors.lastname: Turk
authors.forename: K J
authors.initials: KJ
authors.lastname: Genovese
authors.forename: D J
authors.initials: DJ
authors.lastname: Nisbet
mesh_terms: D000821:Animal Feed / Q000382:microbiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D006332:Cardiomegaly; D003503:Cyclobutanes / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005506:Food Contamination; D005670:Fusarium / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D013552:Swine / Q000097:blood* / Q000254:growth & development / Q000378:metabolism
chemical_list: D003503:Cyclobutanes; C008539:moniliformin