Comparative pharmacology of proton pump inhibitors.
The PPIs are the most effective therapy to suppress gastric acid secretion. These agents decrease acid secretion by inhibiting parietal cell proton pumps. From chemical and pharmacodynamic points of view, subtle differences that exist among the PPIs may influence clinical activity.
Barone
J A
JA
Rutgers University College of Pharmacy, Department of Pharmacy Practice and Administration, 160 Frelinghuysen Road, Piscataway, N.J. 08854-8020, USA. jbarone@cop.rutgers.edu
Horn
J R
JR
D001189:Aryl Hydrocarbon Hydroxylases; D001562:Benzimidazoles / Q000493:pharmacokinetics / Q000494:pharmacology*; D001711:Biotransformation; D065731:Cytochrome P-450 CYP2C19; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D016481:Helicobacter Infections / Q000188:drug therapy*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006899:Mixed Function Oxygenases / Q000235:genetics / Q000378:metabolism; D054328:Proton Pump Inhibitors; D014481:United States
D001562:Benzimidazoles; D054328:Proton Pump Inhibitors; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19