title: Hypohidrosis related to the administration of topiramate to children.
abstract: OBJECTIVE
  Topiramate (TPM) is an antiepileptic agent, first licensed in the United Kingdom in 1994, that is used in the treatment of patients with refractory seizure disorders. TPM is a monosaccharide d-fructose derivate, with sulfamate function, and so far, few adverse side effects have been reported.
  
  
  METHODS
  We describe three patients with epilepsy who were treated with TPM and developed hypohidrosis, heat and exercise intolerance, as well as fever. The sudomotor function was assessed after peripheral stimulation with pilocarpine iontophoresis.
  
  
  RESULTS
  Sweat response was reduced in all three patients. Signs and symptoms ceased after drug suppression.
  
  
  CONCLUSIONS
  This side effect associated with TPM, which has not been described previously, can be clinically significant during heat stress and exercise challenge.
authors.affiliation: Pediatric Neurology, La Paz University Hospital, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Arcas
authors.forename: T
authors.initials: T
authors.lastname: Ferrer
authors.forename: M C
authors.initials: MC
authors.lastname: Roche
authors.forename: A
authors.initials: A
authors.lastname: Martínez-Bermejo
authors.forename: V
authors.initials: V
authors.lastname: López-Martín
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004828:Epilepsies, Partial / Q000188:drug therapy; D004827:Epilepsy / Q000188:drug therapy*; D005334:Fever / Q000139:chemically induced; D005632:Fructose / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007007:Hypohidrosis / Q000139:chemically induced* / Q000175:diagnosis; D007223:Infant; D008297:Male; D013036:Spasms, Infantile / Q000188:drug therapy; D013546:Sweating / Q000187:drug effects; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose