title: [Antimicrobial activities of carbapenems and fourth generation cephems against clinically isolated strains].
abstract: We determined the antibacterial activities of 4 carbapenems (imipenem, panipenem, meropenem and biapenem) and 2 forth generation cephems (cefozopran and cefepime) against 850 bacterial strains (18 species) isolated during the period from January 1998 through September 2000. The 4 carbapenems showed excellent antibacterial activities against methicillin-susceptible S. aureus (MSSA), S. pneumoniae, E. faecalis, P. aeruginosa, M. (B). catarrhalis, B. fragilis and Peptostreptococcus spp. as compared with the cephems except the activity of panipenem against P. aeruginosa. Meropenem showed the highest antibacterial activity against 10 species of all Gram-negative strains determined. The antibacterial activities of 2 forth generation cephems against 6 species of Enterobacteriaceae were equal to or higher than those of carbapenems except meropenem. All drugs showed low antibacterial activities against methicillin-resistant S. aureus (MRSA).
authors.affiliation: Section of Studies, Tokyo Clinical Research Center.
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: C
authors.initials: C
authors.lastname: Nishinari
authors.forename: H
authors.initials: H
authors.lastname: Endo
authors.forename: C
authors.initials: C
authors.lastname: Tamura
authors.forename: K
authors.initials: K
authors.lastname: Jinbo
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology; D015378:Imipenem / Q000494:pharmacology; D000077731:Meropenem; D013845:Thienamycins / Q000494:pharmacology; D000097586:Cefozopran
chemical_list: D015780:Carbapenems; D000077723:Cefepime; D002511:Cephalosporins; D015378:Imipenem; D000077731:Meropenem; D013845:Thienamycins; D000097586:Cefozopran; C039536:panipenem; C065257:biapenem