Why do cells have multiple error-prone DNA polymerases?
Recent years have witnessed the emergence of a plethora of so-called novel DNA polymerases in both eukaryotic and prokaryotic cells. Many of these DNA polymerases are characterized by poor replicational fidelity and low processivity, and are devoid of 3' --> 5' exonuclease activity. This article describes the discovery of these error-prone polymerases and what is known about their biological function.
Friedberg
E C
EC
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9072, USA.
D000818:Animals; D004260:DNA Repair; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase; D006801:Humans
D004259:DNA-Directed DNA Polymerase