Sensitization of hyperthermic treatment of leukemic cell lines by a synthetic peptide.
A compound named HPH-Pep, a peptide constructed from pyridine and histidine units, showed sensitizing effect on the hyperthermic treatment of L-1210, Molt-4, and HL60 cells. The survival rate of these cells was greatly reduced by combined treatment with heating at 44 degrees C and HPH-pep. The treatment of L-1210 and Molt-4 cells with HPH-Pep resulted in a significant breakdown of the survival rate at 44 degrees C. The cell death induced by HPH-Pep under hyperthermic condition seemed to involve iron and peroxide.
Hori
Yasuharu
Y
Research Institute for Advanced Sciences and Technology, Osaka Prefecture University, 1-2 Gakuen-cho, Sakai, 593-8531, Osaka, Japan.
Nagai
Rie
R
Urabe
Naomi
N
Yoshikawa
Toshikazu
T
Otsuka
Masami
M
D006632:Histamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D006979:Hyperthermia, Induced; D007938:Leukemia / Q000473:pathology*; D011725:Pyridines / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
C448824:HPH-Pep; D011725:Pyridines; D011838:Radiation-Sensitizing Agents; D006632:Histamine