Effects of neurotensin receptor activation on brain stimulation reward in Fischer 344 and Lewis rats.
The effects of intracerebroventricular injections of 18 nmol/10 microl of neurotensin, [D-Tyr(11)]neurotensin, or saline on operant responding for brain stimulation reward were investigated in Fischer 344 (F344) and Lewis (LEW) rats using the curve-shift paradigm. [D-Tyr(11)]neurotensin, but not neurotensin, decreased reward threshold in F344 rats while it increased thresholds in LEW rats. Both peptides suppressed maximal rates of responding; this effect was of greater magnitude and longer lasting in LEW than in F344 rats. These findings show that F344 and LEW rat strains are differentially sensitive to activation of central neurotensin receptors that modulate reward-relevant circuitry.
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Centre de Recherche Fernand-Seguin et Département de Psychiatrie, Université de Montréal, 7331, rue Hochelaga, Quebec, H1N 3V2, Montréal, Canada. pbauco@crfs.umontreal.ca
Rompré
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D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009496:Neurotensin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D018028:Receptors, Neurotensin / Q000187:drug effects / Q000378:metabolism*; D012201:Reward; D012965:Sodium Chloride / Q000494:pharmacology; D013045:Species Specificity; D013997:Time Factors
D018028:Receptors, Neurotensin; D009496:Neurotensin; D012965:Sodium Chloride; C068445:neurotensin, Tyr(11)-