Immunosuppressive constituents from Saussurea medusa.
The methanol extract of Saussurea medusa Maxim afforded two lignans: 2alpha-guaicyl-4-oxo-6alpha-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1alpha-hydroxy-2alpha,4alpha-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-epi-phaeophorbide-a and 13-epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3beta-hydroxy-5alpha,6alpha-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.
Duan
Hongquan
H
Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, 770-8505, Tokushima, Japan.
Takaishi
Yoshihisa
Y
Momota
Hiroshi
H
Ohmoto
Yasukazu
Y
Taki
Takao
T
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000302:isolation & purification / Q000494:pharmacology*; D002396:Catechols / Q000302:isolation & purification / Q000494:pharmacology*; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D006139:Guaiacol / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D030441:Saussurea / Q000737:chemistry*
C450169:1-hydroxy-2,5-diguaicyl-3,7-dioxabicyclo(3.3.0)octane; C450168:2-guaicyl-4-oxo-6-catechyl-3,7-dioxabicyclo(3.3.0)octane; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002396:Catechols; D016207:Cytokines; D007166:Immunosuppressive Agents; D017705:Lignans; D006139:Guaiacol