title: Prevention of liver metastasis of human colon cancer by selective matrix metalloproteinase inhibitor MMI-166.
abstract: MMI-166 is a selective inhibitor of matrix metalloproteinase (MMP)-2 and MMP-9. Mice implanted a human colon cancer orthotopically received 200 mg/kg of MMI-166 orally for 5 weeks. Gelatin zymography demonstrated that the administration of MMI-166 remarkably decreased the active MMP-2 expression. Histological examination revealed that MMI-166 showed prominent effect on reduction of the invasive feature of the cancer cells and showed inhibitory effect on tumor vasculature, resulting in the significant decrease of microvessel density of the implanted tumor and liver metastasis compared with the control group. Conclusively, MMI-166 is a potent antiangiogenic oral agent for a human colon cancer.
authors.affiliation: Department of Surgery II, Hamamatsu University School of Medicine, 1-20-1 Handayama, 431-3192, Hamamatsu, Japan.
authors.forename: Kouji
authors.initials: K
authors.lastname: Oba
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Konno
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Tanaka
authors.forename: Megumi
authors.initials: M
authors.lastname: Baba
authors.forename: Kinji
authors.initials: K
authors.lastname: Kamiya
authors.forename: Manabu
authors.initials: M
authors.lastname: Ohta
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shouji
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000517:prevention & control / Q000556:secondary*; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D008819:Mice, Nude; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000033:anatomy & histology; D013449:Sulfonamides / Q000627:therapeutic use*; D014183:Transplantation, Heterologous
chemical_list: D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; C419963:N-alpha-(4-(2-phenyl-2H- tetrazole-5-yl) phenyl sulfonyl)-D-tryptophan; D013449:Sulfonamides