title: Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.
abstract: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data. GEO provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-throughput gene expression and genomic hybridization experiments. GEO is not intended to replace in house gene expression databases that benefit from coherent data sets, and which are constructed to facilitate a particular analytic method, but rather complement these by acting as a tertiary, central data distribution hub. The three central data entities of GEO are platforms, samples and series, and were designed with gene expression and genomic hybridization experiments in mind. A platform is, essentially, a list of probes that define what set of molecules may be detected. A sample describes the set of molecules that are being probed and references a single platform used to generate its molecular abundance data. A series organizes samples into the meaningful data sets which make up an experiment. The GEO repository is publicly accessible through the World Wide Web at http://www.ncbi.nlm.nih.gov/geo.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Lister Hill Center, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Ron
authors.initials: R
authors.lastname: Edgar
authors.forename: Michael
authors.initials: M
authors.lastname: Domrachev
authors.forename: Alex E
authors.initials: AE
authors.lastname: Lash
mesh_terms: D000818:Animals; D003142:Communication; D003628:Database Management Systems; D030541:Databases, Genetic; D005544:Forecasting; D020869:Gene Expression Profiling; D016678:Genome; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D009317:National Library of Medicine (U.S.); D020411:Oligonucleotide Array Sequence Analysis; D014481:United States