Analysis of failure time hierarchical data in the presence of competing risks with application to oral contraceptive pill use in Egypt.
Problems of practical interest in the analysis of data on contraceptive use, from Demographic and Health Surveys (DHS), include the estimation of the cause-specific probability of discontinuation by time t (the cumulative incidence function), in the presence of other competing causes and the evaluation of the effect of covariates on the cause-specific hazards of discontinuation. Methods of analysis of failure time data with competing risks are by now fairly well developed in the case of a simple random sample. However, the data from the DHS are clustered by geographical areas and include multiple episodes per woman. For a marginal (population average) approach, we propose using methods developed for simple random samples with standard errors calculated using a double bootstrap to take account of the clustered hierarchical nature of the data. In the conditional approach, the cause-specific hazards are modelled as log-linear functions of the covariates conditional on random effects of clusters and women, using a three-level multinomial discrete-time logit model. The methods are applied to data from Egypt 1992 DHS on the oral contraceptive pill use.
Ali
M M
MM
Centre for Population Studies, London School of Hygiene & Tropical Medicine, 49-51 Bedford Square, London WC1B 3DP, UK. mohaned.ali@lshtm.ac.uk
Babiker
A G
AG
Cleland
J G
JG
D000293:Adolescent; D000328:Adult; D016000:Cluster Analysis; D003267:Contraception / Q000379:methods* / Q000592:standards; D003271:Contraceptive Agents, Female; D003278:Contraceptives, Oral, Hormonal; D004534:Egypt; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D008954:Models, Biological; D011247:Pregnancy; D012307:Risk Factors
D003271:Contraceptive Agents, Female; D003278:Contraceptives, Oral, Hormonal