Biocompatible microcapsules with enhanced mechanical strength.
A block copolymer, (short-chain alginate)-co-MPEG, was synthesized and used for coating the capsular membranes of the photosensitive microcapsules. The resulted microcapsules exhibited an excellent mechanical strength. The permeability test results revealed that the capsular membrane was freely permeable to cytochrome C and myoglobin, less permeable to serum albumin, and almost impermeable to IgG. In the cell attachment test, the results showed that the surface formed by (short-chain alginate)-co-MPEG copolymer could effectively reduce cell adhesion as compared to poly(L-lysine) and alginate. The microcapsules were evaluated by intraperitoneal implantation experiment of mice. The results demonstrated that microcapsules coated with (short-chain alginate)-co-MPEG were more biocompatible than the conventional alginate/PLL/alginate microcapsules.
Chang
Shwu Jen
SJ
Institute of Biomedical Engineering, National Yang Ming University, Shih Pai, Taipei, Taiwan, ROC.
Lee
Chen Hsen
CH
Hsu
Chun Yuan
CY
Wang
Yng Jiin
YJ
D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials; D002448:Cell Adhesion; D003574:Cytochrome c Group / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D008422:Materials Testing; D051379:Mice; D008813:Mice, Inbred ICR; D009211:Myoglobin / Q000378:metabolism; D010539:Permeability; D012709:Serum Albumin / Q000378:metabolism
D001672:Biocompatible Materials; D003574:Cytochrome c Group; D007074:Immunoglobulin G; D009211:Myoglobin; D012709:Serum Albumin