Sulfasalazine-induced extrinsic allergic alveolitis in a patient with psoriatic arthritis.
We report the first case of a well defined extrinsic allergic alveolitis as a complication of sulfasalazine therapy in a patient treated for psoriatic arthritis. CT of the chest showed small nodular densities over both lungs, BAL demonstrated a highly active lymphocytic alveolitis and transbronchial biopsies revealed lymphoplasmocytic interstitial infiltration. Sulfasalazine as causative agent was proven by an inadvertent rechallenge three years later and a positive lymphocyte transformation test. sulfasalazine; psoriatic arthritis; extrinsic allergic alveolitis
Woltsche
M
M
Hospital Hoergas-Enzenbach, Department of Pulmonary Medicine, Hoergas 30, A-8112 Gratwein, Austria. michael.woltsche@lkh-hoergas.at
Woltsche-Kahr
I
I
Roeger
G M
GM
Aberer
W
W
Popper
H
H
D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000276:immunology; D018501:Antirheumatic Agents / Q000009:adverse effects*; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D012460:Sulfasalazine / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
D018501:Antirheumatic Agents; D012460:Sulfasalazine