Nuclear export: DNA-binding domains find a surprising partner.
Calreticulin, a calcium-binding protein of the endoplasmic reticulum, has been found to function as a nuclear export factor for a large family of nuclear receptors. Atypical nuclear export pathways may thus exist that regulate the compartmentalization and activity of a distinct set of transcription factors.
DeFranco
D B
DB
Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. dod1@pitt.edu
D002135:Calcium-Binding Proteins / Q000378:metabolism*; D037282:Calreticulin; D002467:Cell Nucleus / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D021381:Protein Transport; D012261:Ribonucleoproteins / Q000378:metabolism*
D002135:Calcium-Binding Proteins; D037282:Calreticulin; D004268:DNA-Binding Proteins; D012261:Ribonucleoproteins