title: Increased expression of sialyl Lewis(x) antigen as a prognostic factor in patients with stage 0, I, and II gastric cancer.
abstract: Immunohistochemically detected expression of sialyl Lewis(x) (Le(x)) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le(x) antigen within their tumors had shorter disease-specific intervals than those with negative- or low-expressing tumors (P<0.0001). This difference was noted particularly in stage I-B or II disease. Multivariate Cox's regression analysis revealed sialyl Le(x) antigen expression to be an independent predictor of disease-specific survival (Hazard ratio=9.10). In conclusion, the increased expression of sialyl Le(x) antigen may serve as a prognostic factor after curative surgery for stages 0-II gastric cancer.
authors.affiliation: First Department of Surgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan. nakagoe@net.nagasaki-u.ac.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Nakagoe
authors.forename: Kiyoyasu
authors.initials: K
authors.lastname: Fukushima
authors.forename: Terumitsu
authors.initials: T
authors.lastname: Sawai
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Masa aki
authors.initials: Ma
authors.lastname: Jibiki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nanashima
authors.forename: Kenji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Toru
authors.initials: T
authors.lastname: Yasutake
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Ayabe
authors.forename: Kokichi
authors.initials: K
authors.lastname: Arisawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
mesh_terms: D006801:Humans; D007983:Lewis Blood Group Antigens / Q000235:genetics*; D009367:Neoplasm Staging; D009844:Oligosaccharides / Q000096:biosynthesis*; D011379:Prognosis; D000080506:Sialyl Lewis X Antigen; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D013997:Time Factors
chemical_list: D007983:Lewis Blood Group Antigens; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen