title: Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study.
abstract: OBJECTIVE
  To determine the influence of birth weight on body mass index at different stages of later life; whether this relation persists after accounting for potential confounding factors; and the role of indicators of fetal growth (birth weight relative to parental size) and childhood growth.
  
  
  METHODS
  Longitudinal study of the 1958 British birth cohort.
  
  
  METHODS
  England, Scotland, and Wales.
  
  
  METHODS
  All singletons born 3-9 March 1958 (10 683 participants with data available at age 33).
  
  
  METHODS
  Body mass index at ages 7, 11, 16, 23, and 33 years.
  
  
  RESULTS
  The relation between birth weight and body mass index was positive and weak, becoming more J shaped with increasing age. When adjustments were made for maternal weight, there was no relation between birth weight and body mass index at age 33. Indicators of poor fetal growth based on the mother's body size were not predictive, but the risk of adult obesity was higher among participants who had grown to a greater proportion of their eventual adult height by age 7. In men only, the effect of childhood growth was strongest in those with lower birth weights and, to a lesser extent, those born to lighter mothers.
  
  
  CONCLUSIONS
  Maternal weight (or body mass index) largely explains the association between birth weight and adult body mass index, and it may be a more important risk factor for obesity in the child than birth weight. Birth weight and maternal weight seem to modify the effect of childhood linear growth on adult obesity in men. Intergenerational associations between the mother's and her offspring's body mass index seem to underlie the well documented association between birth weight and body mass index. Other measures of fetal growth are needed for a fuller understanding of the role of the intrauterine environment in the development of obesity.
authors.affiliation: Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH, UK. t.parsons@ich.ucl.ac.uk
authors.forename: T J
authors.initials: TJ
authors.lastname: Parsons
authors.forename: C
authors.initials: C
authors.lastname: Power
authors.forename: O
authors.initials: O
authors.lastname: Manor
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002657:Child Development; D015331:Cohort Studies; D005260:Female; D006128:Growth; D006801:Humans; D007231:Infant, Newborn; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D009035:Mothers; D009765:Obesity / Q000196:embryology / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D012307:Risk Factors; D012923:Social Class