title: ProTherm, Thermodynamic Database for Proteins and Mutants: developments in version 3.0.
abstract: The current release of ProTherm, Thermodynamic Database for Proteins and Mutants, contains more than 10 000 numerical data (300% of the first version) of several thermodynamic parameters, experimental methods and conditions, reversibility of folding, details about the surrounding residues in space for all mutants, structural, functional and literature information. In the current version, we have added information about the source of each protein, identification codes for SWISS-PROT and Protein Information Resource and unique Protein Data Bank (PDB) code for proteins with relevant source. We have also provided additional options to search for data based on PDB code, number of states and reversibility. ProTherm is cross-linked with other sequence, structural, functional and literature databases, and the mutant sites and surrounding residues are automatically mapped on the structure. The ProTherm database is freely available at http://www.rtc.riken.go.jp/jouhou/protherm/protherm.html.
authors.affiliation: RIKEN Tsukuba Institute, Institute of Physical and Chemical Research, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.
authors.forename: M Michael
authors.initials: MM
authors.lastname: Gromiha
authors.forename: Hatsuho
authors.initials: H
authors.lastname: Uedaira
authors.forename: Jianghong
authors.initials: J
authors.lastname: An
authors.forename: Samuel
authors.initials: S
authors.lastname: Selvaraj
authors.forename: Ponraj
authors.initials: P
authors.lastname: Prabakaran
authors.forename: Akinori
authors.initials: A
authors.lastname: Sarai
mesh_terms: D000818:Animals; D003628:Database Management Systems; D030562:Databases, Protein; D016247:Information Storage and Retrieval; D020407:Internet; D009154:Mutation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000235:genetics* / Q000502:physiology; D011786:Quality Control; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D011506:Proteins