Brain metabolic changes during lactate-induced panic: effects of gabapentin treatment.
Six subjects with panic disorder underwent sodium lactate infusions in conjunction with magnetic resonance spectroscopic imaging (MRSI) at study entrance when actively symptomatic and after clinical improvement while under treatment with gabapentin. MRSI was used to serially measure regional brain lactate levels from an axial section at the level of the lateral ventricles at baseline, during lactate infusion and postlactate infusion. Gabapentin treatment appeared to be effective in blocking a lactate-induced panic response but did not alter the magnitude or time course of an abnormal brain lactate response to lactate infusion in all subjects. Additionally, two subjects were reinfused while clinically improved on double-blind placebo and demonstrated a consistent pattern of abnormal brain lactate response.
Layton
M E
ME
The Center for Anxiety and Depression, University of Washington, Seattle, Washington 98105-6099, USA.
Friedman
S D
SD
Dager
S R
SR
D000085:Acetates / Q000008:administration & dosage*; D000328:Adult; D000588:Amines; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D003509:Cyclohexanecarboxylic Acids; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D005260:Female; D000077206:Gabapentin; D006801:Humans; D007262:Infusions, Intravenous; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects* / Q000502:physiology; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D001224:Aspartic Acid; D019344:Lactic Acid; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; C000179:N-acetylaspartate