title: Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria.
abstract: One hallmark of innate immunity apparently conserved from primitive life forms through to humans is the ability of the host to recognize pathogen-associated molecular patterns (PAMPs). Since macrophage pattern recognition receptors are not well defined in Drosophila, we set out to identify such receptors. Our findings reveal that Drosophila macrophages express multiple pattern recognition receptors and that the Drosophila scavenger receptor, dSR-CI, is one such receptor capable of recognizing both gram-negative and gram-positive bacteria, but not yeast. Our data indicate that scavenger receptor bacterial recognition is conserved from insects to humans and may represent one of the most primitive forms of microbial recognition.
authors.affiliation: Laboratory of Developmental Immunology, MassGeneral Hospital for Children, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA. mramet@partners.org
authors.forename: M
authors.initials: M
authors.lastname: Rämet
authors.forename: A
authors.initials: A
authors.lastname: Pearson
authors.forename: P
authors.initials: P
authors.lastname: Manfruelli
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Koziel
authors.forename: V
authors.initials: V
authors.lastname: Göbel
authors.forename: E
authors.initials: E
authors.lastname: Chung
authors.forename: M
authors.initials: M
authors.lastname: Krieger
authors.forename: R A
authors.initials: RA
authors.lastname: Ezekowitz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016466:CHO Cells; D019556:COS Cells; D002175:Candida / Q000378:metabolism; D002478:Cells, Cultured / Q000382:microbiology / Q000502:physiology; D002522:Chlorocebus aethiops; D006224:Cricetinae; D003412:Cricetulus; D029721:Drosophila Proteins / Q000502:physiology*; D004331:Drosophila melanogaster / Q000196:embryology / Q000382:microbiology / Q000502:physiology*; D004926:Escherichia coli / Q000378:metabolism; D019143:Evolution, Molecular; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D006094:Gram-Positive Bacteria / Q000378:metabolism*; D019476:Insect Proteins / Q000096:biosynthesis / Q000235:genetics; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology / Q000502:physiology*; D008969:Molecular Sequence Data; D010587:Phagocytosis / Q000187:drug effects; D011110:Polymorphism, Genetic; D011971:Receptors, Immunologic / Q000502:physiology*; D051116:Receptors, Scavenger; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D051124:Scavenger Receptors, Class C; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000378:metabolism
chemical_list: C488990:AttA protein, Drosophila; C488991:AttB protein, Drosophila; C488989:AttC protein, Drosophila; D029721:Drosophila Proteins; D019476:Insect Proteins; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D011993:Recombinant Fusion Proteins; D051124:Scavenger Receptors, Class C; C495127:Sr-CI protein, Drosophila; C039711:attacin antibacterial protein, insect