title: [Tumors diagnosed in 65 patients with type I neurofibromatosis].
abstract: BACKGROUND
  Type 1 neurofibromatosis patients develop malignant neoplasm more frequently than general population.
  
  
  METHODS
  We have studied 65 patients with neurofibromatosis type 1 because we intend to know the kind of neoplasms that they have presented.
  
  
  RESULTS
  65 patients (48 men and 17 women) fulfilling type 1 neurofibromatosis criteria have been studied. Globally 67 tumors appeared, from which 47 (70%) were benign and 20 (30%) were malignant. Benign tumors included 25 neurofibromas, 11 central nervous system tumors and 11 extraneurological tumors. Malignant tumors accounted for 6 soft tissue sarcomas, 6 carcinomas, 3 malignant CNS tumors and 2 acute lymphoblastic leukemias.
  
  
  CONCLUSIONS
  Presentation of neoplasms is frequent in type 1 neurofibromatosis and constitutes main death and morbility cause.
authors.affiliation: Servicio de Medicina Interna, Hospital General Universitario Valle de Hebrón, Barcelona.
authors.forename: M
authors.initials: M
authors.lastname: Ortiz
authors.forename: V
authors.initials: V
authors.lastname: Falcó
authors.forename: L
authors.initials: L
authors.lastname: Sánchez
authors.forename: E
authors.initials: E
authors.lastname: Ruiz
authors.forename: C
authors.initials: C
authors.lastname: Cervera
authors.forename: J
authors.initials: J
authors.lastname: Alegre
authors.forename: T
authors.initials: T
authors.lastname: Fernández de Sevilla
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000473:pathology*