Three novel repetitive units of reelin.
Reelin is a protein involved in the organization of the developing brain of vertebrates. Reelin is divided into three parts, a F-spondin-like domain, a region including the epitopes of the monoclonal and polyclonal anti-Reelin antibodies, and eight-fold Reelin repeats. Reelin repeats consists of a subrepeat A, an EGF-like domain, and a subrepeat B. We found that the anti-Reelin antibodies' recognition region consists of three repetitive units. The correspondence of the repetitive units with the antigenicity is discussed.
Ichihara
H
H
Department of Bioinformatics, Biomolecular Engineering Research Institute, 6-2-3, Furuedai, Suita, Osaka 565-0874, Japan.
Jingami
H
H
Toh
H
H
D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001923:Brain Chemistry; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D018604:Epitope Mapping; D016326:Extracellular Matrix Proteins / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D017434:Protein Structure, Tertiary; D000091042:Reelin Protein; D012091:Repetitive Sequences, Nucleic Acid; D017386:Sequence Homology, Amino Acid; D012697:Serine Endopeptidases; D014714:Vertebrates
D000911:Antibodies, Monoclonal; D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D012697:Serine Endopeptidases