title: [Surgery for complications of chronic pancreatitis].
abstract: At least 50 % of all patients with chronic pancreatitis require surgical treatment in the course of their disease. Indications for surgery are intractable pain, intra- and extrapancreatic complications and the suspicion of a carcinoma. The basic principles of surgery are resection and drainage. The choice of the surgical procedure depends on the morphological expression and the localization of the pathological changes. Regarding resections in the head-area, previous studies demonstrated uniformly the superiority of the duodenum-preserving pancreas head resection (DPPHR) compared to the Kausch-Whipple operation with and without maintenance of the pylorus. Drainage procedures (pain recurrence in 20-40 % in the long-term course) and left pancreatic resections (de-novo diabetes mellitus in up to 45 %) should be considered critically. Between May 1994 and November 2000 117 patients underwent surgical therapy for complications of chronic pancreatitis at our institution. Resections were performed in 68 % of the patients and drainage procedures in 20 %. There was no mortality. Over the years the proportion of the DPPHR increased in comparison to the Kausch-Whipple procedure and the number of the drainage operations decreased continuously. The DPPHR was significantly superior to the Kausch-Whipple procedure with regard to the glucose metabolism and the quality-of-life. In the spectrum of surgical procedures in chronic pancreatitis, the DPPHR represents a modern, organ-preserving procedure for patients with complications in the pancreas head.
authors.affiliation: Klinik für Abdominal-, Transplantations- und Gefässchirurgie der Universität Leipzig, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Witzigmann
authors.forename: F
authors.initials: F
authors.lastname: Geissler
authors.forename: D
authors.initials: D
authors.lastname: Uhlmann
authors.forename: J
authors.initials: J
authors.lastname: Fangmann
authors.forename: K
authors.initials: K
authors.lastname: Kohlhaw
authors.forename: A
authors.initials: A
authors.lastname: Tannapfel
authors.forename: S
authors.initials: S
authors.lastname: Ludwig
authors.forename: J
authors.initials: J
authors.lastname: Hauss
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D004322:Drainage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007813:Laparotomy; D008297:Male; D008722:Methods; D008875:Middle Aged; D009154:Mutation; D010148:Intractable Pain / Q000209:etiology / Q000601:surgery; D010179:Pancreas / Q000601:surgery*; D010193:Pancreaticojejunostomy; D010195:Pancreatitis / Q000150:complications* / Q000235:genetics / Q000601:surgery*; D011788:Quality of Life; D013997:Time Factors