Risk factors in congenital abdominal wall defects (omphalocele and gastroschisi): a study in a series of 265,858 consecutive births.
The aim of this study was to describe the prevalence at birth of two abdominal wall defects (AWD), omphalocela and gastroschisis and to identify possible etiologic factors. The AWD came from 265,858 consecutive births of known ouome registered in the registry of congenital malformations of Strasbourg for the period 1979 to 1998. Request information on the child, the pregnancy, the parents and the family was obtained for cases and for controls. Hundred five cases with AWD were analysed, 55.2 % were omphalocele and 44.8 % were gastroschisis. The mean prevalence rate for omphalocele was 2.18 per 10,000 and for gastroschisis 1.76 per 10,000. Associated malformations were found in 74.1 % of omphalocele compared with 53.2 % of gastroschisis; 29.3 % of fetuses with omphalocele had an abnormal karyotype, 44,8 % had a recognizable syndrome, association or an unspecified malformation pattern; 51.0 % of fetuses with gastroschisis had additional malformations that were not of chromosomal origin, but 1 case. Antenatal ultrasound examination was able to detect 39 (67.2 %) cases of omphaloceles and 27 (57.4 %) cases of gastroschisis. In 30 (51.7 %) cases of omphalocele and in 7 (14.9 %) cases of gastroschisis parents opted for termination of pregnancy. The overall survival rate was 14 (24.1 %) for omphalocele and 30 (63.8 %) for gastroschisis. Weight, length and head circumference at birth of infants with AWD were less than those of controls. The weight of placenta of infants with AWD was not different from the weight of placenta of controls. Gastroschisis was associated with significantly younger maternal age than omphalocele. Pregnancies with AWD were more often complicated by threatened abortion, oligohydramnios and polyhydramnios. Mothers of children with AWD took more often medication during pregnancy than mothers of controls.
Stoll
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Service de génétique médicale, centre hospitalo-universitaire, hôpital de Hautepierre, avenue Molière, 67098 Strasbourg cedex, France. Claude.Stoll@chru-strasbourg.fr
Alembik
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Y
Dott
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Roth
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MP
D000009:Abdominal Muscles / Q000002:abnormalities*; D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D000022:Abortion, Spontaneous / Q000453:epidemiology; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D005602:France / Q000453:epidemiology; D020139:Gastroschisis / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D006554:Hernia, Umbilical / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D016104:Oligohydramnios / Q000453:epidemiology; D006831:Polyhydramnios / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011296:Prenatal Diagnosis; D015995:Prevalence; D012042:Registries / Q000706:statistics & numerical data; D012307:Risk Factors; D012423:Rural Health; D012744:Sex Ratio; D014504:Urban Health