[Cerebrovascular diseases in patients aged 15 to 40 years: neuropathological findings in 47 cases].
Cerebrovascular diseases in patients between 15 and 40 years old are not a frequent subject in Latin-American literature, especially when focusing on neuropathology. We analyzed 47 brains from necropsies performed from 1987 to 1997 and selected on a basis of age and the presence of vascular pathology. From the 47 analyzed brains, 26 belonged to females (55.3%). When distributed among age groups, 12.8% (n=6) affected patients from 15 to 20 yo, 51,1% (n=24) from 21 to 30 yo, 36,2% (n=17) from 31 to 40 yo. The underlying diseases were: cardiac and haemathologic (19.2%), pregnancy complications (12.76%), infections, diseases of blood vessels and neurological (10.1% each) amongst others. The neuropathological abnormalities included cerebral and/or cerebellar herniation (16%), cerebral edema (13.8%), subarachnoid hemorrhage (10%), recent cerebral infarction (9%), intraparenchymatous hemorrhage (8.14%), hypoxic-ischemic encephalopathy (3%) and other events such as Sneddon syndrome and Lupus vasculitis. These findings express that the cerebrovascular phenomena in this age group are unique and closely related with the underlying disease.
Maggio
E M
EM
Seção de Microscopia Eletrônica e Neuropatologia, Serviço de Anatomia-Patológica, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
Montemór-Netto
M R
MR
Gasparetto
E L
EL
Reis-Filho
J S
JS
Tironi
F A
FA
Torres
L F
LF
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000473:pathology*; D005260:Female; D006331:Heart Diseases / Q000209:etiology / Q000473:pathology; D006402:Hematologic Diseases / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D017678:Sex Distribution