title: Sepragel sinus (hylan B) as a postsurgical dressing for endoscopic sinus surgery.
abstract: OBJECTIVE
  To assess the safety and efficacy of Sepragel sinus, a hylan B gel (cross-linked hyaluronic acid molecule), when used as a postoperative dressing after endoscopic sinus surgery as a facilitator of healing and a preventative for scarring and stenosis.
  
  
  METHODS
  Ten patients undergoing bilateral endoscopic ethmoidectomy in an outpatient specialty hospital operating room underwent complete filling of a randomly selected right or left ethmoidectomy cavity with Sepragel sinus. Outcome measures were synechiae, middle meatal stenosis, mucosal status, mucosal regeneration, transparency of Sepragel sinus, and subjective pain and congestion.
  
  
  RESULTS
  Sepragel sinus significantly improved all outcome measures by week 2 and remained statistically significant for reduction of synechiae and stenosis.
  
  
  CONCLUSIONS
  Sepragel sinus is useful as a space-occupying gel stent to separate sinus mucosal surfaces. The data strongly support the superiority of Sepragel sinus over no treatment in the control of postethmoidectomy synechiae and middle meatal stenosis, as well as early improvement in mucosal healing and postoperative pain.
  
  
  CONCLUSIONS
  Because of its biocompatibility, lack of inflammatory response, transparency, and ability to fill any complex volume, Sepragel sinus offers distinct advantages over currently used stenting materials.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Manhattan Eye, Ear, and Throat Hospital, 1421 Third Avenue, New York, NY 10021, USA. ckimmelman@aol.com
authors.forename: C P
authors.initials: CP
authors.lastname: Kimmelman
authors.forename: D R
authors.initials: DR
authors.lastname: Edelstein
authors.forename: H J
authors.initials: HJ
authors.lastname: Cheng
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000704:Analysis of Variance; D001458:Bandages; D002908:Chronic Disease; D003251:Constriction, Pathologic / Q000209:etiology / Q000517:prevention & control; D004724:Endoscopy / Q000009:adverse effects; D015521:Ethmoid Sinusitis / Q000601:surgery*; D005122:Exudates and Transudates; D005260:Female; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects; D015508:Nasal Obstruction / Q000209:etiology / Q000517:prevention & control; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D012008:Recurrence; D015607:Stents; D013492:Suppuration; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D005782:Gels; D006820:Hyaluronic Acid