DNA cleavage by pentadentate iron(II) complexes containing fluoro-substituted phenyl groups.
Four pentadentate iron(II) complexes containing non- or fluoro-substituted phenyl group (2b-2e) were synthesized and cleaving activity of them to pUC19 DNA was evaluated in the presence of hydrogen peroxide. DNA cleavage activity increased with the number of substituted fluorine atoms on the phenyl group of 2b.
Kurosaki
Hiromasa
H
Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
Maruyama
Aoi
A
Koike
Hiroyuki
H
Kuroda
Naoko
N
Ishikawa
Yoshinobu
Y
Goto
Masafumi
M
D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D004578:Electron Spin Resonance Spectroscopy; D004587:Electrophoresis, Agar Gel; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology*; D005461:Fluorine / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry
D005296:Ferrous Compounds; D005461:Fluorine; D004247:DNA; D006861:Hydrogen Peroxide