title: Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear.
abstract: We studied the natural course of high-risk human papillomavirus (HPV) infection and cytological regression in women referred for colposcopy because of abnormal cervical smears. We found that high-risk HPV clearance preceded regression of cervical lesions by an average of 3 months. The cumulative 1-year rate of cytological regression was similar in women with mild and moderate dyskaryotic cervical smears. Thus, retesting of high-risk HPV after 6 months in women with mild to moderate dyskaryosis predicts cytological regression.
authors.forename: M A
authors.initials: MA
authors.lastname: Nobbenhuis
authors.forename: T J
authors.initials: TJ
authors.lastname: Helmerhorst
authors.forename: A J
authors.initials: AJ
authors.lastname: van den Brule
authors.forename: L
authors.initials: L
authors.lastname: Rozendaal
authors.forename: F J
authors.initials: FJ
authors.lastname: Voorhorst
authors.forename: P D
authors.initials: PD
authors.lastname: Bezemer
authors.forename: R H
authors.initials: RH
authors.lastname: Verheijen
authors.forename: C J
authors.initials: CJ
authors.lastname: Meijer
mesh_terms: D000328:Adult; D003127:Colposcopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D013997:Time Factors; D014626:Vaginal Smears