Establishment and characterization of a human adenoid cystic carcinoma line of the salivary gland which is serially transplantable and spontaneously metastasises to the lung in nude mice.
Adenoid cystic carcinoma (ACC) is a rare malignant tumour of the head and neck occurring in the salivary glands. We established a human ACC line which is serially transplantable in nude mice and designated it as KOA-1. The KOA-1 tumour doubled in 9.3 days and retained the histological characteristics of a solid pattern of ACC even after 22 serial passages. The KOA-1 metastasised to the lung when transplanted subcutaneously into the back. This tumour line may serve as a useful model for exploration of the biological behaviour and treatment of human ACC.
Umeda
M
M
Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe 650-0017, Japan. ume@med.kobe-u.ac.jp
Komatsubara
H
H
Nishimatsu
N
N
Oku
N
N
Shibuya
Y
Y
Yokoo
S
S
Komori
T
T
D000818:Animals; D003528:Carcinoma, Adenoid Cystic / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008854:Microscopy, Electron; D008875:Middle Aged; D009368:Neoplasm Transplantation / Q000379:methods*; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D014062:Tongue Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured