title: Effect of bile acids on absorption of nitrendipine in healthy subjects.
abstract: OBJECTIVE
  To examine whether bile acids such as ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) can influence the absorption of nitrendipine, a highly lipophilic calcium channel blocker.
  
  
  METHODS
  Six healthy subjects received nitrendipine (10 mg) with and without UDCA (50 mg) and CDCA (200 and 600 mg) with an interval of 1 approximately 2 weeks between study phases.
  
  
  RESULTS
  Bile acids decreased the Cmax (ng ml(-1)) [control 10.9 +/- 5.8 (mean+/- s.d.), UDCA 5.0 +/- 4.7 (95% confidence interval for difference; 3.9, 7.8, P = 0.0006), CDCA (600 mg) 5.0 +/- 3.9 (2.6, 9.2, P = 0.0059)] and AUC (ng ml(-1) h) [(control; 60 +/- 36, UDCA 15 +/- 13 (20, 73, P = 0.0064), CDCA (600 mg) 19 +/- 19 (21, 63, P = 0.0038)] of nitrendipine, while elimination half-life remained unchanged.
  
  
  CONCLUSIONS
  These results suggest that the amount of nitrendipine absorbed was decreased when the drug was administered with UDCA and CDCA.
authors.affiliation: Department of Clinical Pharmacology, Jichi Medical School, Tochigi 329-0498, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: A
authors.initials: A
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: A
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001647:Bile Acids and Salts / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002635:Chenodeoxycholic Acid / Q000494:pharmacology; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009568:Nitrendipine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000494:pharmacology
chemical_list: D001647:Bile Acids and Salts; D002121:Calcium Channel Blockers; D002756:Cholagogues and Choleretics; D002635:Chenodeoxycholic Acid; D014580:Ursodeoxycholic Acid; D009568:Nitrendipine