title: Sentra, a database of signal transduction proteins.
abstract: Sentra (http://www-wit.mcs.anl.gov/sentra) is a database of signal transduction proteins with the emphasis on microbial signal transduction. The database was updated to include classes of signal transduction systems modulated by either phosphorylation or methylation reactions such as PAS proteins and serine/threonine kinases, as well as the classical two-component histidine kinases and methyl-accepting chemotaxis proteins. Currently, Sentra contains signal transduction proteins from 43 completely sequenced prokaryotic genomes as well as sequences from SWISS-PROT and TrEMBL. Signal transduction proteins are annotated with information describing conserved domains, paralogous and orthologous sequences, and conserved chromosomal gene clusters. The newly developed user interface supports flexible search capabilities and extensive visualization of the data.
authors.affiliation: Mathematics and Computer Science Division, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439, USA. maltsev@mcs.anl.gov
authors.forename: Natalia
authors.initials: N
authors.lastname: Maltsev
authors.forename: E
authors.initials: E
authors.lastname: Marland
authors.forename: G X
authors.initials: GX
authors.lastname: Yu
authors.forename: S
authors.initials: S
authors.lastname: Bhatnagar
authors.forename: R
authors.initials: R
authors.lastname: Lusk
mesh_terms: D002633:Chemotaxis; D003196:Computer Graphics; D017124:Conserved Sequence; D030562:Databases, Protein; D016678:Genome; D000071677:Histidine Kinase; D016247:Information Storage and Retrieval; D020407:Internet; D008745:Methylation; D005810:Multigene Family; D010766:Phosphorylation; D011387:Prokaryotic Cells / Q000378:metabolism*; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017385:Sequence Homology; D015398:Signal Transduction
chemical_list: D011506:Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D000071677:Histidine Kinase