Thermosensitive polymer-modified liposomes.
Temperature-sensitive liposomes are considered to be a promising tool to achieve site-specific delivery of drugs. These liposomes have been prepared using lipids whose membranes undergo a gel-to-liquid crystalline phase transition a few degrees above physiological temperature. However, recently, temperature-sensitization of liposomes has been attempted using thermosensitive polymers. So far, functional liposomes whose contents release behavior, surface properties, and affinity to cell surface can be controlled in a temperature-dependent manner, have been developed according to this strategy. The design and function of these thermosensitive polymer-modified liposomes have been outlined in this review.
Kono
K
K
Department of Applied Materials Science, Graduate School of Engineering, Osaka Prefecture University, 1-1, Gakuen-cho, Sakai, Osaka 599-8531, Japan. kono@ams.osakafu-u.ac.jp
D000818:Animals; D016503:Drug Delivery Systems; D006358:Hot Temperature; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D016707:Tissue Fixation
D008081:Liposomes; D011108:Polymers