Langerhans cell histiocytosis following childhood acute lymphoblastic leukemia.
Langerhans cell histiocytosis (LCH) is a clonal proliferation of Langerhans cells of unknown etiology that results in a range of clinical manifestations. LCH has been known to be associated with a variety of malignant diseases. A 7-year-old boy was treated for standard-risk acute lymphoblastic leukemia (ALL) at age 2 years, on a Children's Cancer Group chemotherapy protocol for 3 years and developed LCH 2 years after completion of chemotherapy. The case and a review of literature on the association of LCH and ALL are presented.
Raj
A
A
Department of Pediatric Hematology/Oncology, University of Louisville, Louisville, Kentucky 40202, USA.
Bendon
R
R
Moriarty
T
T
Suarez
C
C
Bertolone
S
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D015448:Leukemia, B-Cell / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology