Homology between a 173-kb region from mouse chromosome 10, telomeric to the Ifng locus, and human chromosome 12q15.
We sequenced a 173-kb region of mouse chromosome 10, telomeric to the Ifng locus, and compared it with the human homologous sequence located on chromosome 12q15 using various sequence analysis programs. This region has a low density of genes: one gene was detected in the mouse and the human sequences and a second gene was detected only in the human sequence. The mouse gene and its human orthologue, which are expressed in the immune system at a low level, produce a noncoding mRNA. Nonexpressed sequences show a higher degree of conservation than exons in this genomic region. At least three of these conserved sequences are also conserved in a third mammalian species (sheep or cow).
Vigneau
S
S
Unité des Virus Lents (CNRS URA 1930), Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
Levillayer
F
F
Crespeau
H
H
Cattolico
L
L
Caudron
B
B
Bihl
F
F
Robert
C
C
Brahic
M
M
Weissenbach
J
J
Bureau
J F
JF
D000818:Animals; D001483:Base Sequence; D022202:Chromosomes, Artificial, Bacterial; D002881:Chromosomes, Human, Pair 12; D018076:DNA, Complementary; D015870:Gene Expression; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D016615:Telomere
D018076:DNA, Complementary; D007371:Interferon-gamma