Brain metastases in paediatric solid tumours.
Brain metastases in children with cancer are rare and their incidence is significantly lower (5-10%) than that reported in adults. The development of metastatic brain tumours in children is usually a manifestation of advanced disease and commonly occur after, or at the time of progression at other sites. This review summarises the salient clinical features of the most common paediatric solid tumours that metastasize to the brain including neuroblastoma, musculoskeletal sarcomas, germ cell tumours and melanoma.
Spunt
S L
SL
Department of Haematology-Oncology St Jude Children's Research Hospital, University of Tennessee, College of Medicine, Memphis 38105-2794, USA.
Thompson
S J
SJ
Pappo
A S
AS
D001932:Brain Neoplasms / Q000503:physiopathology* / Q000556:secondary* / Q000628:therapy; D002648:Child; D018237:Germinoma / Q000503:physiopathology* / Q000556:secondary* / Q000628:therapy; D006801:Humans; D008545:Melanoma / Q000503:physiopathology* / Q000556:secondary* / Q000628:therapy; D009447:Neuroblastoma / Q000503:physiopathology* / Q000556:secondary* / Q000628:therapy; D012509:Sarcoma / Q000503:physiopathology* / Q000556:secondary* / Q000628:therapy