title: Central injection of interleukin-13 potentiates LPS-induced sickness behavior in rats.
abstract: Systemic administration of the bacterial endotoxin lipopolysaccharide (LPS) has profound depressive effects on behavior that are mediated by the inducible expression of proinflammatory cytokines such as interleukin-1 (IL-1), IL-6 and tumor necrosis factor-alpha (TNF-alpha) in the brain. To assess the regulatory effects of the anti-inflammatory cytokine IL-13 on LPS-induced sickness behavior, rats injected i.p. with LPS were administered rat recombinant IL-13 i.c.v. IL-13 (300 ng) potentiated the behavioral effects of LPS (125 microg/kg) when both molecules were co-injected. Administration of IL-13 (300 ng) 12 h prior to LPS (150 microg/kg) did not block the depressing effects of LPS on social exploration. These results indicate that IL-13 acts as a proinflammatory cytokine in the brain.
authors.affiliation: Integrative Neurobiology Laboratory, INRA-INSERM U394, Institut Fracois Magendie, Rue Camille Saint-Saëns, 33077 Bordeaux cedex, France.
authors.forename: R M
authors.initials: RM
authors.lastname: Bluthé
authors.forename: A
authors.initials: A
authors.lastname: Bristow
authors.forename: J
authors.initials: J
authors.lastname: Lestage
authors.forename: C
authors.initials: C
authors.lastname: Imbs
authors.forename: R
authors.initials: R
authors.lastname: Dantzer
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000276:immunology*; D004357:Drug Synergism; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D018793:Interleukin-13 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012919:Social Behavior
chemical_list: D018793:Interleukin-13; D008070:Lipopolysaccharides