title: MR ventilation-perfusion imaging of human lung using oxygen-enhanced and arterial spin labeling techniques.
abstract: Magnetic resonance ventilation-perfusion (V/Q) imaging has been demonstrated using oxygen and arterial spin labeling techniques. Inhaled oxygen is used as a paramagnetic contrast agent in ventilation imaging using a multiple inversion recovery (MIR) approach. Pulmonary perfusion imaging is conducted using a flow-sensitive alternating inversion recovery with an extra radiofrequency pulse (FAIRER) technique. A half Fourier single-short turbo spin echo (HASTE) sequence is used for data acquisition in both techniques. V/Q imaging was performed in ten of the twenty volunteers, while either ventilation or perfusion was imaged in the other ten. This V/Q imaging scheme is completely noninvasive, does not involve ionized radiation, and shows promising potential for clinical use in the diagnosis of lung diseases such as pulmonary embolism.
authors.affiliation: Department of Radiology, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA. vmai@enh.org
authors.forename: V M
authors.initials: VM
authors.lastname: Mai
authors.forename: A A
authors.initials: AA
authors.lastname: Bankier
authors.forename: P V
authors.initials: PV
authors.lastname: Prasad
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: P
authors.initials: P
authors.lastname: Storey
authors.forename: R R
authors.initials: RR
authors.lastname: Edelman
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D006801:Humans; D008168:Lung / Q000033:anatomy & histology*; D008171:Lung Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D012680:Sensitivity and Specificity; D013113:Spin Labels; D014692:Ventilation-Perfusion Ratio
chemical_list: D003287:Contrast Media; D013113:Spin Labels; D010100:Oxygen