An efficient and stereoselective synthesis of beta-D-Arap-(1-->2)-beta-D-Galp-(1-->3)-beta-D-Galp-(1-->4)-alpha-D-Manp, a tetrasaccharide fragment of Leishmania major lipophosphoglycan.
A tetrasaccharide fragment of Leishmania major lipophosphoglycan (which seems to be involved in a biological mechanism for the parasite transmission) has been synthesised using the thioglycoside, trichloroacetimidate and halide-exchange glycosylation procedures and step-wise chain elongation strategy.
Yashunsky
D V
DV
School of Life Sciences, Division of Biological Chemistry and Molecular Microbiology, Carnelley Building, University of Dundee, Dundee DD1 4HN, UK.
Higson
A P
AP
Ross
A J
AJ
Nikolaev
A V
AV
D000818:Animals; D002240:Carbohydrate Sequence; D006028:Glycosphingolipids / Q000737:chemistry*; D006031:Glycosylation; D018320:Leishmania major / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
C449503:Arap-(1-2)-Galp-(1-3)-Galp-(1-4)-Manp; D006028:Glycosphingolipids; D009844:Oligosaccharides; C008290:lipophosphonoglycan