title: Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus.
abstract: During the past several decades, there has been a steady increase in the frequency of opportunistic invasive fungal infections (IFIs) in immunocompromised patients. However, there is substantial controversy concerning optimal diagnostic criteria for these IFIs. Therefore, members of the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group formed a consensus committee to develop standard definitions for IFIs for clinical research. On the basis of a review of literature and an international consensus, a set of research-oriented definitions for the IFIs most often seen and studied in immunocompromised patients with cancer is proposed. Three levels of probability are proposed: "proven," "probable," and "possible." The definitions are intended for use in the context of clinical and/or epidemiological research, not for clinical decision making.
authors.forename: S
authors.initials: S
authors.lastname: Ascioglu
authors.forename: J H
authors.initials: JH
authors.lastname: Rex
authors.forename: B
authors.initials: B
authors.lastname: de Pauw
authors.forename: J E
authors.initials: JE
authors.lastname: Bennett
authors.forename: J
authors.initials: J
authors.lastname: Bille
authors.forename: F
authors.initials: F
authors.lastname: Crokaert
authors.forename: D W
authors.initials: DW
authors.lastname: Denning
authors.forename: J P
authors.initials: JP
authors.lastname: Donnelly
authors.forename: J E
authors.initials: JE
authors.lastname: Edwards
authors.forename: Z
authors.initials: Z
authors.lastname: Erjavec
authors.forename: D
authors.initials: D
authors.lastname: Fiere
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
authors.forename: J
authors.initials: J
authors.lastname: Maertens
authors.forename: J F
authors.initials: JF
authors.lastname: Meis
authors.forename: T F
authors.initials: TF
authors.lastname: Patterson
authors.forename: J
authors.initials: J
authors.lastname: Ritter
authors.forename: D
authors.initials: D
authors.lastname: Selleslag
authors.forename: P M
authors.initials: PM
authors.lastname: Shah
authors.forename: D A
authors.initials: DA
authors.lastname: Stevens
authors.forename: T J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis; D002177:Candidiasis / Q000150:complications* / Q000175:diagnosis; D003657:Decision Making; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D009369:Neoplasms / Q000150:complications* / Q000276:immunology; D009894:Opportunistic Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology