Network dynamics and cell physiology.
Complex assemblies of interacting proteins carry out most of the interesting jobs in a cell, such as metabolism, DNA synthesis, movement and information processing. These physiological properties play out as a subtle molecular dance, choreographed by underlying regulatory networks. To understand this dance, a new breed of theoretical molecular biologists reproduces these networks in computers and in the mathematical language of dynamical systems.
Tyson
J J
JJ
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA. tyson@vt.edu
Chen
K
K
Novak
B
B
D016203:CDC2 Protein Kinase / Q000235:genetics / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D046911:Macromolecular Substances; D008954:Models, Biological; D009154:Mutation; D010641:Phenotype; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics / Q000502:physiology; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000502:physiology; D013598:Systems Theory
D046911:Macromolecular Substances; D029702:Schizosaccharomyces pombe Proteins; D016203:CDC2 Protein Kinase