title: Association of CD4+/CD56+/CD57+/CD8+(dim) large granular lymphocytic leukemia, splenic B-cell lymphoma with circulating villous lymphocytes, and idiopathic erythrocytosis.
abstract: In this paper we report a rare association of a splenic marginal zone B-cell lymphoma with villous lymphocytes and a T-cell large granular lymphocytic leukemia coexpressing CD4 and CD8 as well as CD56 and CD57 natural killer-associated markers in an asymptomatic patient investigated because of an occasional finding of erythrocytosis and leukocytosis in routine blood analysis. We also discuss the possible reasons for this particular association.
authors.affiliation: Service of Clinical Hematology, Hospital Geral Santo António, Porto, Portugal. mmc.lima@clix.pt
authors.forename: M
authors.initials: M
authors.lastname: Lima
authors.forename: C
authors.initials: C
authors.lastname: Gonçalves
authors.forename: L
authors.initials: L
authors.lastname: Marques
authors.forename: M C
authors.initials: MC
authors.lastname: Martin
authors.forename: M A
authors.initials: MA
authors.lastname: Teixeira
authors.forename: M L
authors.initials: ML
authors.lastname: Queirós
authors.forename: A H
authors.initials: AH
authors.lastname: Santos
authors.forename: A
authors.initials: A
authors.lastname: Balanzategui
authors.forename: R
authors.initials: R
authors.lastname: Garcia-Sanz
authors.forename: A C
authors.initials: AC
authors.lastname: Pinto-Ribeiro
authors.forename: B
authors.initials: B
authors.lastname: Justiça
authors.forename: A
authors.initials: A
authors.lastname: Orfão
mesh_terms: D000368:Aged; D001773:Blood Cells / Q000473:pathology; D015704:CD4 Antigens / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D018959:CD57 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D016130:Immunophenotyping; D015458:Leukemia, T-Cell / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D008214:Lymphocytes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D011086:Polycythemia / Q000150:complications*; D013154:Spleen / Q000473:pathology
chemical_list: D015704:CD4 Antigens; D019002:CD56 Antigen; D018959:CD57 Antigens; D016827:CD8 Antigens