Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.
Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor delta (PPARdelta) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving PPARdelta(-/-) mice exhibit a striking reduction in adiposity relative to wild-type levels. This effect is not reproduced in mice harboring an adipose tissue-specific deletion of PPARdelta, and thus likely reflects peripheral PPARdelta functions in systemic lipid metabolism. Finally, we observe that PPARdelta is dispensable for polyp formation in the intestine and colon of APC(min) mice, inconsistent with its recently proposed role in the establishment of colorectal tumors. Together, these observations reveal specific roles for PPARdelta in embryo development and adipocyte physiology, but not cancer.
Barak
Yaacov
Y
Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Liao
Debbie
D
He
Weimin
W
Ong
Estelita S
ES
Nelson
Michael C
MC
Olefsky
Jerrold M
JM
Boland
Richard
R
Evans
Ronald M
RM
D000273:Adipose Tissue / Q000378:metabolism*; D000483:Alleles; D000818:Animals; D001835:Body Weight; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005091:Exons; D006706:Homeostasis; D050356:Lipid Metabolism; D051379:Mice; D008822:Mice, Transgenic; D008957:Models, Genetic; D010920:Placenta / Q000378:metabolism*; D011127:Polyps / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D011995:Recombination, Genetic; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors