title: Effect of calcium antagonists on ultrastructure of myocardial microvessels during open heart surgery under conditions of pharmacological and cold cardioplegia.
abstract: Ultrastructure of myocardial microvessels was examined during surgical correction of congenital heart disease (ventricular septal defect) under conditions of cold and pharmacological low-potassium cardioplegia without perfusion. Addition of calcium antagonist verapamil to cardioplegic solution prevented postischemic damage to vascular and perivascular structures occurring during reperfusion and body temperature rise.
authors.affiliation: Institute of Circulatory Pathology, Ministry of Health of the Russian Federation, Novosibirsk.
authors.forename: A M
authors.initials: AM
authors.lastname: Volkov
authors.forename: G M
authors.initials: GM
authors.lastname: Kazanskaya
authors.forename: G G
authors.initials: GG
authors.lastname: Chasovskikh
authors.forename: T M
authors.initials: TM
authors.lastname: D'yakonitsa
authors.forename: G P
authors.initials: GP
authors.lastname: Zhdanov
authors.forename: V N
authors.initials: VN
authors.lastname: Lomivorotov
mesh_terms: D001831:Body Temperature; D002118:Calcium / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006348:Cardiac Surgical Procedures; D002648:Child; D003080:Cold Temperature; D006321:Heart / Q000187:drug effects; D006324:Heart Arrest, Induced; D006325:Heart Atria / Q000378:metabolism / Q000648:ultrastructure; D006331:Heart Diseases / Q000151:congenital; D006801:Humans; D007035:Hypothermia; D007511:Ischemia; D008833:Microcirculation / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D013696:Temperature; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D014700:Verapamil; D002118:Calcium