Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata.
In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, odorine and odorinol, were obtained as active constituents. These compounds exhibited potent anti-carcinogenic effects in a two-stage carcinogenesis test of mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, both compounds showed remarkable inhibitory effects in two-stage mouse skin carcinogenesis models induced by nitric oxide (NO) donors such as (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) or peroxynitrite as an initiator and TPA as a promoter. From these results, it was concluded that odorine and odorinol inhibited both the initiation and promotion stages of two-stage skin carcinogenesis.
Inad
A
A
Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan. inada@pharm.setsunan.ac.jp
Nishino
H
H
Kuchide
M
M
Takayasu
J
J
Mukainaka
T
T
Nobukuni
Y
Y
Okuda
M
M
Tokuda
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D015197:Carcinogenicity Tests / Q000379:methods; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D018632:Mice, Inbred SENCAR; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control; D008517:Phytotherapy / Q000379:methods; D018515:Plant Leaves / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011759:Pyrrolidines; C053564:odorinol