title: Early thrombolysis inhibits peri-infarct depolarizations in embolic MCA occlusion.
abstract: Rats submitted to middle cerebral artery (MCA) clot embolism were treated with tissue plasminogen activator (TPA) 1.5 and 3.5 h post-occlusion. Reperfusion patterns were monitored by measuring cortical laser-Doppler flow; the direct current potential was measured to detect peri-infarct depolarizations (PID), a known mechanism of ischemic injury. TPA treatment induced reperfusion in 58% of treated animals that was delayed by 41 +/- 7 min (mean +/- s.e.m.) from treatment onset. The probability of reperfusion did not differ significantly between the two treatment groups. TPA treatment led to a 3-fold reduced frequency of PID if administered early or if successful reperfusion was observed (each p < 0.001). Early thrombolysis inhibits, but does not block, PID as an important mechanism of ischemic injury in embolic stroke.
authors.affiliation: Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians-University, Marchioninistr. 15, D-81377 Munich, Germany.
authors.forename: O G
authors.initials: OG
authors.lastname: Schüler
authors.forename: N
authors.initials: N
authors.lastname: Plesnila
authors.forename: D
authors.initials: D
authors.lastname: Otto
authors.forename: A J
authors.initials: AJ
authors.lastname: Baethmann
authors.forename: T
authors.initials: T
authors.lastname: Back
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology; D013181:Cortical Spreading Depression / Q000502:physiology*; D004569:Electroencephalography; D004594:Electrophysiology; D005343:Fibrinolytic Agents / Q000494:pharmacology; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology* / Q000628:therapy*; D017078:Laser-Doppler Flowmetry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000494:pharmacology
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator