Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels.
We have recently identified a new G protein-coupled receptor, msr/apj, whose transcripts are detected in the endothelium of the primary blood vessels and the newly forming heart (Mech. Dev. 1999;84:199). Its expression during formation of the embryonic vasculature incited us to investigate whether expression of the receptor also increased during the formation of retinal vessels, which occurs postnatally in the mouse. Interestingly, msr/apj transcripts are indeed associated with the forming vessels and trace the centrifugal extension of the superficial vasculature. We also show that expression of the endogenous ligand apelin is upregulated at the leading edge of vessel formation.
Saint-Geniez
Magali
M
Unité INSERM U-397, CHU Rangueil, Toulouse, France.
Masri
Bernard
B
Malecaze
François
F
Knibiehler
Bernard
B
Audigier
Yves
Y
D054392:Adipokines; D000818:Animals; D000073861:Apelin; D000075244:Apelin Receptors; D002352:Carrier Proteins / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D051379:Mice; D008810:Mice, Inbred C57BL; D011956:Receptors, Cell Surface / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled; D012171:Retinal Vessels / Q000254:growth & development* / Q000378:metabolism; D015854:Up-Regulation
D054392:Adipokines; D000073861:Apelin; D000075244:Apelin Receptors; C402826:Apln protein, mouse; C491285:Aplnr protein, mouse; D002352:Carrier Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D011956:Receptors, Cell Surface; D017448:Receptors, Dopamine D2; D043562:Receptors, G-Protein-Coupled