title: Primitive small round cell tumour of the adrenal gland presenting with fever of unknown origin and t(12;22)(q13;q12) cytogenetic finding.
abstract: This report describes a left adrenal tumour in a 16 year old Chinese girl who presented with fever of unknown origin. The histological and ultrastructural features of the adrenal tumour were those of a primitive small round cell tumour with neuroendocrine differentiation. Cytogenetic analysis of cultured tumour cells showed a reciprocal translocation t(12;22)(q13;q12). This is the first example of such a tumour being reported in the adrenal gland. The adrenal tumour was also the cause of the fever, which subsided after the removal of the tumour.
authors.affiliation: Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China. akylam@hotmail.com
authors.forename: K Y
authors.initials: KY
authors.lastname: Lam
authors.forename: C Y
authors.initials: CY
authors.lastname: Lo
authors.forename: T W
authors.initials: TW
authors.lastname: Shek
authors.forename: E S
authors.initials: ES
authors.lastname: Ma
authors.forename: W Y
authors.initials: WY
authors.lastname: Au
authors.forename: G C
authors.initials: GC
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology; D000313:Adrenal Medulla / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000235:genetics / Q000473:pathology; D002881:Chromosomes, Human, Pair 12; D002892:Chromosomes, Human, Pair 22; D005260:Female; D005334:Fever / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D014178:Translocation, Genetic