Proton release as a modulator of presynaptic function.
In this issue of Neuron, DeVries (2001) describes experiments suggesting that acidification of the synaptic cleft can reduce Ca2+ channel activity and thereby act as a brake on tonic synaptic release of glutamate from cone cells. This work hints at a potentially important new facet to the regulation of synaptic transmission.
Traynelis
S F
SF
Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA.
Chesler
M
M
D000818:Animals; D017729:Presynaptic Terminals / Q000502:physiology*; D011522:Protons; D009435:Synaptic Transmission / Q000502:physiology*
D011522:Protons