Relationship between estradiol 16 alpha-hydroxylation and human papillomavirus infection in cervical cell transformation.
The ovarian steroid hormone estradiol and its metabolite estrone were examined in 45 normal women and 127 premenopausal women with precancerous cervical lesions. Interviews, colposcopy and cervical scrapings were performed. The mean +/- SD values for estradiol and estrone were 0.07 +/- 0.08 ng/ml and 0.06 +/- 0.02 ng/ml, respectively in normal subjects. Corresponding data in patients with cervical intraepithelial neoplasia alone or in association with human papillomavirus (HPV) infection were 0.074 +/- 0.03 ng/ml and 0.076 +/- 0.03 ng/ml or 0.080 +/- 0.03 ng/ml and 0.148 +/- 0.02 ng/ml, respectively, which revealed a significantly greater extent of estrogenic action in the latter population (p < 0.05). We considered that the presence of HPV infection probably increased 16 alpha-hydroxylation of estradiol, providing a possible link between the viral and hormonal elements, possibly having a bearing on the etiology of the disease.
Salazar
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Medical Research Unit in Reproductive Medicine, Social Security Mexican Institute, Apartado Postal 86-056, Mexico City, Mexico.
Mercado
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Sojo
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Salcedo
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D000293:Adolescent; D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases; D001706:Biopsy; D002472:Cell Transformation, Viral / Q000502:physiology*; D065727:Cytochrome P-450 CYP2C8; D065729:Cytochrome P-450 CYP2C9; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000096:biosynthesis* / Q000097:blood; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000378:metabolism* / Q000821:virology*; D018709:Statistics, Nonparametric; D039181:Steroid 16-alpha-Hydroxylase; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000378:metabolism* / Q000821:virology*
D006894:Hydroxyestrones; C026702:16-hydroxyestrone; D004958:Estradiol; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; C450259:CYP2C8 protein, human; D065727:Cytochrome P-450 CYP2C8; D039181:Steroid 16-alpha-Hydroxylase