title: Prognostic significance of thymidine phosphorylase and p53 co-expression in esophageal squamous cell carcinoma.
abstract: This study investigated the prognostic significance of thymidine phosphorylase (TP) and p53 expression in 96 surgically resected primary esophageal squamous cell carcinomas. Expression was assessed using immunohistochemical staining methods. Prognostic values were determined by multivariate analysis using Cox's proportional hazards model. Although TP expression was not correlated with p53 expression, it was associated with genetic alteration of the latter. In univariate analysis, TP expression emerged as a significant prognostic factor but p53 expression did not. However, in multivariate analysis, despite TP not being a significant independent predictor of survival, co-expression of TP together with p53 did represent a statistically significant prognostic factor.
authors.affiliation: Department of Academic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Oota
authors.initials: O
authors.lastname: Makoto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takeda
authors.forename: Leu
authors.initials: L
authors.lastname: Ting-Leig
authors.forename: Okazumi
authors.initials: O
authors.lastname: Shinnichi
authors.forename: Matsubara
authors.initials: M
authors.lastname: Hisahiro
authors.forename: Funami
authors.initials: F
authors.lastname: Yutaka
authors.forename: Nabeya
authors.initials: N
authors.lastname: Yoshihiro
authors.forename: Susumu
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Gunji
authors.forename: Takao
authors.initials: T
authors.lastname: Suzuki
authors.forename: Ochiai
authors.initials: O
authors.lastname: Takenori
authors.forename: Shimada
authors.initials: S
authors.lastname: Hideaki
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000201:enzymology*; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D011379:Prognosis; D016019:Survival Analysis; D013939:Thymidine Phosphorylase / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53; D013939:Thymidine Phosphorylase