Acutifolins A-F, a new flavan-derived constituent and five new flavans from Brosimum acutifolium.
Acutifolin A (1), a novel constituent with a bicyclo[3.3.1]non-3-ene-2,9-dione ring, acutifolins B-F (2-6), five new flavans, and three known flavans were isolated from the bark of Brosimum acutifolium, a Brazilian folk medicine ("Mururé"). Their structures were elucidated by spectroscopic methods, including 2D NMR.
Takashima
J
J
Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan. a-ohsaki.fm@tmd.ac.jp
Ohsaki
A
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification*; D001938:Brazil; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D008519:Medicine, Traditional; D008968:Molecular Conformation; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids