Comparative studies of the biological activities of lysosomotropic aminoesters and quaternary ammonium salts on the yeast Saccharomyces cerevisiae.
The biological activity of lysosomotropic n-alkyl N,N-dimethylglycinates (DMG-n) was compared with that of a quaternary ammonium salt IM (methochloride of DMG-12). The activity of the glycinates appeared to be carbon chain length dependent and was similar at pH 6 and pH 8. Nutritional auxotrophy and respiratory deficiencies have no influence on DMG-n sensitivity. Both IM and DMG-n inhibit plasma membrane H+-ATPase activity while mitochondrial ATPase is relatively non-sensitive to glycinates. No cross-resistance to IM and DMG-n was observed.
Obłak
E
E
Institute of Microbiology, University of Wrocław, Przybyszewskiego 65/73, 51-148 Wrocław, Poland.
Lachowicz
T M
TM
Luczyński
J
J
Witek
S
S
D000251:Adenosine Triphosphatases / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes / Q000187:drug effects*; D008928:Mitochondria / Q000201:enzymology; D006180:Proton-Translocating ATPases / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism
D000644:Quaternary Ammonium Compounds; D000251:Adenosine Triphosphatases; D006180:Proton-Translocating ATPases