title: Neuroleptic malignant syndrome during zuclopenthixol therapy in X-linked cerebral adrenoleukodystrophy.
abstract: An 8 year-old boy with X-ALD under treatment with simvastatin developed a severe adverse reaction when the dose of his other medication, zuclopenthixol was increased. Both drugs were withdrawn after a diagnosis of neuroleptic malignant syndrome was made.
authors.affiliation: Department of Paediatrics, University Hospital Maastricht, The Netherlands. mrub@skin.azm.nl
authors.forename: M E
authors.initials: ME
authors.lastname: Rubio-Gozalbo
authors.forename: D A
authors.initials: DA
authors.lastname: van Waardenburg
authors.forename: P P
authors.initials: PP
authors.lastname: Forget
authors.forename: L J
authors.initials: LJ
authors.lastname: Spaapen
authors.forename: A
authors.initials: A
authors.lastname: Verrips
authors.forename: P C
authors.initials: PC
authors.lastname: Vroomen
mesh_terms: D000326:Adrenoleukodystrophy / Q000150:complications / Q000235:genetics*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002653:Child Behavior Disorders / Q000188:drug therapy / Q000523:psychology; D003006:Clopenthixol / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000150:complications / Q000235:genetics*; D019821:Simvastatin / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D003006:Clopenthixol; D019821:Simvastatin