Analgesic sesquiterpene dilactone from Mikania cordata.
The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show significant analgesic activity.
Ahmed
M
M
Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh. phardu@citechco.net
Rahman
M T
MT
Alimuzzaman
M
M
Shilpi
J A
JA
D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D019659:Asteraceae; D004305:Dose-Response Relationship, Drug; D007783:Lactones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045788:Sesquiterpenes, Germacrane
D000700:Analgesics; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C443732:deoxymikanolide; D019342:Acetic Acid