title: Optimized intensity-modulated arc therapy for prostate cancer treatment.
abstract: We recently implemented intensity-modulated arc therapy (IMAT) at our institution. In this study, we evaluate the dosimetric merits of the application of this technique to the treatment of prostate cancer. Each IMAT treatment plan incorporated bilateral overlapping arcs. The dose from each beam segment was computed using the three-dimensional dose model of a clinical treatment planning system (Render Plan 3.5, Precision Therapy). The weights assigned to the individual arc segments were optimized using a gradient search method. For 12 patients, comparisons were made between the IMAT treatment plans and corresponding plans using fixed cone-beam intensity-modulated radiotherapy (IMRT) from a commercial inverse planning system (CORVUS, NOMOS Corp.). We found that the optimized IMAT treatments produced similar dose distributions to the IMRT deliveries. Compared with the IMRT treatments, the IMAT treatments produced slightly less target dose homogeneity with consistently greater sparing of the rectum in regions of lower dose. The trade-off between target dose conformity and rectum sparing can be adjusted in both optimization procedures. Because the total beam-on time for IMAT delivery is 1 to 2 minutes with approximately 5-6 minutes of patient setup time, the delivery efficiency of the IMAT treatment was significantly better than the multiple-beam IMRT treatment.
authors.affiliation: Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. lma001@umaryland.edu
authors.forename: L
authors.initials: L
authors.lastname: Ma
authors.forename: C X
authors.initials: CX
authors.lastname: Yu
authors.forename: M
authors.initials: M
authors.lastname: Earl
authors.forename: T
authors.initials: T
authors.lastname: Holmes
authors.forename: M
authors.initials: M
authors.lastname: Sarfaraz
authors.forename: X A
authors.initials: XA
authors.lastname: Li
authors.forename: D
authors.initials: D
authors.lastname: Shepard
authors.forename: P
authors.initials: P
authors.lastname: Amin
authors.forename: S
authors.initials: S
authors.lastname: DiBiase
authors.forename: M
authors.initials: M
authors.lastname: Suntharalingam
authors.forename: C
authors.initials: C
authors.lastname: Mansfield
mesh_terms: D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted