title: A case of trisomy 28 in cattle revealed by both banding and FISH-mapping techniques.
abstract: A case of presumed trisomy 22 in cattle, as earlier reported, was investigated by using both chromosome banding and FISH-mapping techniques. A one year old Hereford female calf showed slow growth, brachygnathia superior, hyper-salivation. strabisbusmus convergence, macroclitoris and supernumerary nipples. At necropsy, a duplication of the uterine cervix and an extra aortic cusp were also observed. The R-banding technique revealed that BTA28 (not BTA22, as erroneously earlier reported) was involved in the trisomy. This was confirmed by FISH-mapping with chromosome-specific markers. Phenotypic characteristics achieved in cattle carrier and those earlier reported in humans carrying partial trisomy 10 were discussed.
authors.affiliation: National Research Council (CNR), IABBAM, Laboratory of Animal Cytogenetics, Naples, Italy. L.Iannuzzi@iabbam.na.cnr.it
authors.forename: L
authors.initials: L
authors.lastname: Iannuzzi
authors.forename: G P
authors.initials: GP
authors.lastname: Di Meo
authors.forename: P S
authors.initials: PS
authors.lastname: Leifsson
authors.forename: A
authors.initials: A
authors.lastname: Eggen
authors.forename: K
authors.initials: K
authors.lastname: Christensen
mesh_terms: D000818:Animals; D001011:Aorta / Q000002:abnormalities; D002417:Cattle / Q000002:abnormalities* / Q000235:genetics; D002869:Chromosome Aberrations / Q000662:veterinary; D002871:Chromosome Banding / Q000662:veterinary; D002987:Clitoris / Q000002:abnormalities; D005260:Female; D005819:Genetic Markers; D007569:Jaw Abnormalities / Q000662:veterinary; D007621:Karyotyping / Q000662:veterinary; D014314:Trisomy / Q000235:genetics*; D014599:Uterus / Q000002:abnormalities
chemical_list: D005819:Genetic Markers