CD14 and LBP in endotoxemia and infections caused by Gram-negative bacteria.
It is now well recognized that plasma LPS-binding protein (LBP) and membrane CD14 present at the surface of cells of the myelo/monocytic lineage are central molecules of the innate immune system, in response to LPS or to bacterial products. This paper reviews the role of LBP and CD14 in models of endotoxemia and infection.
Heumann
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Division of Infectious Diseases, CHUV, Lausanne, Switzerland. dheumann@hola.hospvd.ch
D000209:Acute-Phase Proteins; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000276:immunology* / Q000517:prevention & control; D016905:Gram-Negative Bacterial Infections / Q000276:immunology*; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000502:physiology*; D008562:Membrane Glycoproteins; D051379:Mice; D018345:Mice, Knockout; D000099231:Lipopolysaccharide-Binding Protein
D000209:Acute-Phase Proteins; D000911:Antibodies, Monoclonal; D002352:Carrier Proteins; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D000099231:Lipopolysaccharide-Binding Protein