Interferon gamma gene polymorphism and susceptibility to, and severity of, rheumatoid arthritis.
A strong association between an interferon gamma (IFN-gamma) gene polymorphism and rheumatoid arthritis susceptibility and severity has been reported in a case-control study. We investigated this polymorphism in 103 patients with early rheumatoid arthritis and 130 controls. Severity of rheumatoid arthritis was measured after 4-year follow-up with a validated radiographic score. The median radiographic score in patients increased from 1 (IQR 0-4) to 11.5 (2-35) over the 4-year follow up. The distribution of IFN-gamma alleles did not differ between patients and controls, and the distribution of radiographic scores did not differ among patients carrying the different IFN-gamma alleles. We have failed to confirm the association between the IFN-gamma gene polymorphism and rheumatoid arthritis susceptibility or severity.
Constantin
A
A
Navaux
F
F
Lauwers-Cancès
V
V
Abbal
M
M
van Meerwijk
J P
JP
Mazières
B
B
Cambon-Thomsen
A
A
Cantagrel
A
A
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000145:classification / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index
D007371:Interferon-gamma