The use of antibody D8/17 to identify B cells in adults with obsessive-compulsive disorder.
Compared with healthy control subjects, individuals with childhood-onset obsessive-compulsive disorder (OCD) have been reported to have a higher percentage of B cells that react with the monoclonal antibody D8/17, a marker for rheumatic fever. This study sought to replicate these findings in adults with OCD. Double-blind analyses of blood samples from 29 consecutive adults with primary OCD and 26 healthy control subjects were conducted to determine the percentage of B cells identified by D8/17. Using a standard criterion of > or =12% labeled B cells to denote positivity, rates of D8/17 positive individuals did not significantly differ between the OCD (58.6%) and control (42.3%) groups. Early age of onset was not a predictor of D8/17 positivity in the OCD group. The percentage of B cells identified by the monoclonal antibody marker D8/17 did not distinguish adults with OCD from control subjects, nor did it distinguish a sub-group of adults with OCD who described pre-pubertal onset of their OCD symptoms.
Eisen
J L
JL
Department of Psychiatry and Human Behavior, Butler Hospital, Brown University School of Medicine, 345 Blackstone Blvd., Providence, RI 02906, USA. jane_eisen@brown.edu
Leonard
H L
HL
Swedo
S E
SE
Price
L H
LH
Zabriskie
J B
JB
Chiang
S Y
SY
Karitani
M
M
Rasmussen
S A
SA
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000276:immunology*; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies
D000911:Antibodies, Monoclonal