Naturally occurring anti-Salmonella agents.
Polygodial and (2E)-hexenal were found to possess antibacterial activity against Salmonella choleraesuis with the minimum bactericidal concentrations (MBC) of 50 microg/mL (0.17 mM) and 100 microg/mL (0.98 mM), respectively. The time kill curve study showed that these two alpha,beta-unsaturated aldehydes were bactericidal against this food-borne bacterium at any stage of growth. However, they showed different effects on the growth of S. choleraesuis. The combination of polygodial and anethole exhibited strong synergism on their bacteriostatic action but only marginal synergism on their bactericidal action.
Kubo
I
I
Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112, USA. ikubo@uclink4.berkeley.edu
Fujita
K
K
D000447:Aldehydes / Q000494:pharmacology*; D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005421:Flavoring Agents / Q000494:pharmacology; D005516:Food Microbiology; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D012475:Salmonella / Q000187:drug effects* / Q000254:growth & development
D000447:Aldehydes; D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000900:Anti-Bacterial Agents; D005421:Flavoring Agents; C010463:n-hexanal; C006578:anethole