title: Origin and differentiation of dendritic cells.
abstract: Despite extensive, recent research on the development of dendritic cells (DCs), their origin is a controversial issue in immunology, with important implications regarding their use in cancer immunotherapy. Although, under defined experimental conditions, DCs can be generated from myeloid or lymphoid precursors, the differentiation pathways that generate DCs in vivo remain unknown largely. Indeed, experimental results suggest that the in vivo differentiation of a particular DC subpopulation could be unrelated to its possible experimental generation. Nevertheless, the analysis of DC differentiation by in vivo and in vitro experimental systems could provide important insights into the control of the physiological development of DCs and constitutes the basis of a model of common DC differentiation that we propose.
authors.affiliation: Department of Cell Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain. ardavin@bio.ucm.es
authors.forename: C
authors.initials: C
authors.lastname: Ardavín
authors.forename: G
authors.initials: G
authors.lastname: Martínez del Hoyo
authors.forename: P
authors.initials: P
authors.lastname: Martín
authors.forename: F
authors.initials: F
authors.lastname: Anjuère
authors.forename: C F
authors.initials: CF
authors.lastname: Arias
authors.forename: A R
authors.initials: AR
authors.lastname: Marín
authors.forename: S
authors.initials: S
authors.lastname: Ruiz
authors.forename: V
authors.initials: V
authors.lastname: Parrillas
authors.forename: H
authors.initials: H
authors.lastname: Hernández
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D051379:Mice