title: Combinatorial synthesis of 3-(amidoalkyl) and 3-(aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors.
abstract: Preparation and screening of mixture libraries based on a 2-arylindole scaffold resulted in the discovery of potent ligands for a variety of G-protein coupled receptors.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. christopher_willoughby@merck.com
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Willoughby
authors.forename: Steven M
authors.initials: SM
authors.lastname: Hutchins
authors.forename: Keith G
authors.initials: KG
authors.lastname: Rosauer
authors.forename: Madhumeeta J
authors.initials: MJ
authors.lastname: Dhar
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Chapman
authors.forename: Gary G
authors.initials: GG
authors.lastname: Chicchi
authors.forename: Sharon
authors.initials: S
authors.lastname: Sadowski
authors.forename: David H
authors.initials: DH
authors.lastname: Weinberg
authors.forename: Smita
authors.initials: S
authors.lastname: Patel
authors.forename: Lorraine
authors.initials: L
authors.lastname: Malkowitz
authors.forename: Jerry
authors.initials: J
authors.lastname: Di Salvo
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Pacholok
authors.forename: Kang
authors.initials: K
authors.lastname: Cheng
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical; D019204:GTP-Binding Proteins; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D011956:Receptors, Cell Surface / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D018039:Receptors, Tachykinin / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000588:Amines; D007211:Indoles; D008024:Ligands; D011956:Receptors, Cell Surface; D019707:Receptors, Chemokine; D011985:Receptors, Serotonin; D018039:Receptors, Tachykinin; D019204:GTP-Binding Proteins