Vaccination with DNA of the Mycobacterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae.
A DNA vaccine composed of the gene for the common mycobacterial secreted protein antigen 85B was demonstrated to protect the mouse foot pad against infection with Mycobacterium leprae. The protective effect was demonstrated by a 61%-88% reduction in the bacterial number, a protective effect less than that of BCG. The same DNA vaccine has been shown to protect mice against M. tuberculosis infection, and the importance of testing other candidate tuberculosis vaccines for their potential to protect against leprosy is discussed.
Roche
P W
PW
Mycobacterial Research Laboratory, Anandaban Leprosy Hospital, Kathmandu, Nepal. paulwroche@hotmail.com
Neupane
K D
KD
Failbus
S S
SS
Kamath
A
A
Britton
W J
WJ
D000217:Acyltransferases; D000818:Animals; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D005528:Foot / Q000382:microbiology; D007918:Leprosy / Q000382:microbiology / Q000517:prevention & control*; D051379:Mice; D009166:Mycobacterium leprae / Q000254:growth & development / Q000472:pathogenicity; D014611:Vaccination; D019444:Vaccines, DNA / Q000008:administration & dosage*; D014774:Virulence
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D019444:Vaccines, DNA; D000217:Acyltransferases; C121433:antigen 85B, Mycobacterium tuberculosis