A cobalt-phosphine complex directed Reformatsky approach to a stereospecific synthesis of the dolastatin 10 unit dolaproine (Dap).
Pettit
G R
GR
Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-2404, USA. bpettit@asu.edu
Grealish
M P
MP
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D047630:Depsipeptides; D007202:Indicators and Reagents; D009842:Oligopeptides / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents; D013237:Stereoisomerism
D000596:Amino Acids; D000970:Antineoplastic Agents; D047630:Depsipeptides; D007202:Indicators and Reagents; D009842:Oligopeptides; D010720:Phosphines; D011759:Pyrrolidines; D012997:Solvents; C098461:dolaproine; D003035:Cobalt; C064570:dolastatin 10