Effect of impurities on the matrix-assisted laser desorption/ionization mass spectra of insulin.
The effect of impurity (sodium sulfate Na2SO4; copper sulfate CuSO4; potassium ferrocyanide K4Fe(CN)6; and triammonium citrate (NH4)3C6H5O7) concentration on the positive matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) spectra of insulin is described. 2,5-Dihydroxybenzoic acid was used as a desorption matrix. The estimated maximum concentrations of tested salts for which no insulin signal was observed were determined.
Bajuk
A
A
Institute of Physics, Maria Curie-Sklodowska University, 20-031 Lublin, Poland.
Głuch
K
K
Michalak
L
L
D004340:Drug Contamination; D005841:Gentisates; D062385:Hydroxybenzoates; D007004:Hypoglycemic Agents / Q000032:analysis*; D007328:Insulin / Q000032:analysis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D005841:Gentisates; D062385:Hydroxybenzoates; D007004:Hypoglycemic Agents; D007328:Insulin; C010925:2,5-dihydroxybenzoic acid