Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2-n-propylquinoline.
It was reported previously that 2-n-propylquinoline was active against the epimastigote form of Trypanosoma cruzi. The effects of oral treatments with benznidazole and 2-n-propylquinoline were evaluated in Balb/c mice infected with T. cruzi chronically. The reference drug and 2-n-propylquinoline were administered 60 days post-infection for 30 days at 25 mg/mL. At 35 days post-treatment, the serological tests (ELISA) of the 2-n- propylquinoline-treated mice were significantly different from the controls (p = 0.01) and the benznidazole-treated mice (p = 0.03), while this was not the case at 85 days post-treatment. These results are encouraging for continuing the investigation of other analogues of 2-n-propylquinoline in experimental chronic Chagas' disease.
Nakayama
H
H
Instituto de Investigaciones en Ciencias de la Salud, Department of Tropical Medicine, Casilla de Correo 2511, Asunción, Paraguay.
Ferreira
M E
ME
Rojas de Arias
A
A
Vera de Bilbao
N
N
Torres
S
S
Schinini
A
A
Fournet
A
A
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009593:Nitroimidazoles / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D011804:Quinolines / Q000627:therapeutic use*; D027821:Rutaceae; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000276:immunology* / Q000302:isolation & purification
C116019:2-propylquinoline; D009593:Nitroimidazoles; D010936:Plant Extracts; D011804:Quinolines; D014344:Trypanocidal Agents; C009999:benzonidazole