title: Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4'-Y-(1,1'-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives.
abstract: The derivatives of 3-(4'-bromo-[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains of Mycobacterium sp. (ATCC) and M. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction to measure the cellular viability.
authors.affiliation: Instituto de Química, Biological Chemistry Laboratory, Universidade Estadual de Campinas, C.P. 6154, CEP 13083-970, S.P., Campinas, Brazil.
authors.forename: A O
authors.initials: AO
authors.lastname: de Souza
authors.forename: R R
authors.initials: RR
authors.lastname: Santos Júnior
authors.forename: J F
authors.initials: JF
authors.lastname: Ferreira-Júlio
authors.forename: J A
authors.initials: JA
authors.lastname: Rodriguez
authors.forename: P S
authors.initials: PS
authors.lastname: Melo
authors.forename: M
authors.initials: M
authors.lastname: Haun
authors.forename: D N
authors.initials: DN
authors.lastname: Sato
authors.forename: N
authors.initials: N
authors.lastname: Durán
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006224:Cricetinae; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D008168:Lung / Q000166:cytology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
chemical_list: D000475:Alkenes; D000995:Antitubercular Agents; D001713:Biphenyl Compounds; C013658:propylene