Fibrosarcoma associated with a benign cystic teratoma of the ovary.
OBJECTIVE
A case of ovarian fibrosarcoma associated with a benign cystic teratoma is described.


METHODS
A 32-year-old patient with an ovarian tumor detected by routine gynecological examination was referred to our hospital. In addition to histopathological examination of the resected tumor, immunohistochemical studies as well as a cytogenetic analysis by comparative genomic hybridization were carried out.


RESULTS
The 7-cm-sized tumor consisted of two different components: a fibrosarcoma and a benign cystic teratoma. The teratoma contained elements of all three germ layers and lacked any focus of immature teratoma. A fibrosarcoma was immediately connected to the teratoma. The sarcoma cells showed eight mitoses per 10 high-power fields on average and exhibited immunohistochemical reactivity for vimentin only. Cytogenetic analysis of the fibrosarcoma using comparative genomic hybridization revealed imbalances of chromosomes 9, 12, and 16. After a 1-year follow-up, there were no signs of tumor recurrence or systemic disease.


CONCLUSIONS
To the authors' knowledge, this is the second report of an association of ovarian fibrosarcoma and benign cystic teratoma, and the first including a cytogenetic analysis.
Krüger
Stefan
S
Institute of Pathology, Medical University of Lübeck, Lübeck, Germany. krueger@patho.mu-luebeck.de
Schmidt
Hannelore
H
Küpker
Wolfgang
W
Rath
Friedrich W
FW
Feller
Alfred C
AC
D000328:Adult; D005260:Female; D005354:Fibrosarcoma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D010048:Ovarian Cysts / Q000150:complications* / Q000235:genetics / Q000473:pathology; D010051:Ovarian Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology; D013724:Teratoma / Q000150:complications* / Q000235:genetics / Q000473:pathology