Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs.
OBJECTIVE
To observe polysaccharide of Spirulina platensis (PSp) on the hematopoietic system of mouse and dogs which were damaged by injection of cyclophosphamide (CTX) and 60Co-gamma irradiation.


METHODS
CTX and 60Co gamma ray were used to induce bone marrow damage, and the experimental animals were ig with different dose of PSp in vivo, after 12-d and 21-d administration, the whole blood cells and nucleated cells in bone marrow were measured, and the DNA in bone marrow were inspected by UV-spectrophotometer.


RESULTS
CTX and 60Co-gamma irradiation induced hemopoietic system damage in mice and dogs, respectively. PSp 30, 60 mg/kg increased the level of the white cells in blood and nucleated cells and DNA in bone marrow in mice but had no effects on red cells and hemoglobins. PSp 12 mg/kg increased the level of red cells, white cells, and hemoglobins in blood and nucleated cells in bone marrow in dogs (P < 0.01), and the effects of PSp 60 mg/kg were better than that of berbamine hydrochloride 60 mg/kg.


CONCLUSIONS
PSp has chemo-protective and radio-protective capability, and may be a potential adjunct to cancer therapy.
Zhang
H Q
HQ
The Medical and Pharmaceutical Academe of Yangzhou University, Yangzhou 225001, China.
Lin
A P
AP
Sun
Y
Y
Deng
Y M
YM
D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry*; D003037:Cobalt Radioisotopes; D003520:Cyclophosphamide; D004285:Dogs; D005260:Female; D006397:Hematinics / Q000494:pharmacology; D006413:Hematopoietic System / Q000187:drug effects*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011134:Polysaccharides / Q000494:pharmacology* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011897:Random Allocation; D053545:Spirulina
D001426:Bacterial Proteins; D003037:Cobalt Radioisotopes; D006397:Hematinics; D011134:Polysaccharides; D011837:Radiation-Protective Agents; D003520:Cyclophosphamide