title: Virus population dynamics, fitness variations and the control of viral disease: an update.
abstract: Viral quasispecies dynamics and variations of viral fitness are reviewed in connection with viral disease control. Emphasis is put on resistance of human immunodeficiency virus and some human DNA viruses to antiviral inhibitors. Future trends in multiple target antiviral therapy and new approaches based on virus entry into error catastrophe (extinction mutagenesis) are discussed.
authors.affiliation: Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Spain. edomingo@cbm.uam.es
authors.forename: E
authors.initials: E
authors.lastname: Domingo
authors.forename: A
authors.initials: A
authors.lastname: Mas
authors.forename: E
authors.initials: E
authors.lastname: Yuste
authors.forename: N
authors.initials: N
authors.lastname: Pariente
authors.forename: S
authors.initials: S
authors.lastname: Sierra
authors.forename: M
authors.initials: M
authors.lastname: Gutiérrez-Riva
authors.forename: L
authors.initials: L
authors.lastname: Menéndez-Arias
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D004267:DNA Viruses / Q000187:drug effects / Q000235:genetics; D024882:Drug Resistance, Viral / Q000235:genetics; D006678:HIV / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control*; D019694:Hepatitis B, Chronic / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy / Q000517:prevention & control; D016296:Mutagenesis; D012328:RNA Viruses / Q000187:drug effects / Q000235:genetics; D014777:Virus Diseases / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D019380:Anti-HIV Agents