title: Incidence and reversibility of organ failure in the course of sterile or infected necrotizing pancreatitis.
abstract: BACKGROUND
  Multiple organ failure (MOF) and infected necrosis are both considered severe adverse events during the course of necrotizing pancreatitis.
  
  
  OBJECTIVE
  The incidence of MOF and its reversibility in patients with necrotizing pancreatitis are influenced by the presence or absence of infected necrosis.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Intensive care, university teaching hospital.
  
  
  METHODS
  Forty-three patients with necrotizing pancreatitis and failure of at least 1 organ were prospectively included.
  
  
  METHODS
  Organ failure defined according to the Goris classification; MOF defined by the simultaneous occurrence of 3 organ failures and graded with an MOF score. Microbial status of necrosis was assessed by percutaneous or intraoperative sampling. Surgical drainage was performed in patients with infected necrosis, whereas sterile necrosis was managed conservatively.
  
  
  RESULTS
  Infected necrosis occurred in 27 patients (63%). The mean (+/-SEM) number of organ failures was greater in cases of infection (3.6 +/- 1.1 vs 2.6 +/- 1.5; P =.02). Multiple organ failure occurred more frequently in cases of infected necrosis (23/27 vs 7/16; P<.01) and was responsible for an increased mortality in this subgroup (33% vs 6%; P =.1). The severity of MOF graded by the MOF score was related to the bacteriologic status of necrosis.
  
  
  CONCLUSIONS
  The higher mortality commonly attributed to MOF in patients with infected necrosis appears to be due to a higher frequency and an increased severity of MOF. Conservative management in patients with severe necrotizing pancreatitis and sterile necrosis complicated by MOF is supported by the high reversibility rate of MOF and the low mortality rate observed in this series.
authors.affiliation: Department of Anesthesiology, Hôpital Beaujon, University Paris VII, Clichy, France.
authors.forename: J
authors.initials: J
authors.lastname: Le Mée
authors.forename: F
authors.initials: F
authors.lastname: Paye
authors.forename: A
authors.initials: A
authors.lastname: Sauvanet
authors.forename: D
authors.initials: D
authors.lastname: O'Toole
authors.forename: P
authors.initials: P
authors.lastname: Hammel
authors.forename: J
authors.initials: J
authors.lastname: Marty
authors.forename: P
authors.initials: P
authors.lastname: Ruszniewski
authors.forename: J
authors.initials: J
authors.lastname: Belghiti
mesh_terms: D018806:APACHE; D019072:Antibiotic Prophylaxis; D016022:Case-Control Studies; D004322:Drainage; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000453:epidemiology* / Q000628:therapy; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D010289:Parenteral Nutrition, Total; D011446:Prospective Studies; D012121:Respiration, Artificial; D016896:Treatment Outcome