Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides.
The structural modification of the benzylic ether region of oxime 1 has resulted in the identification of several novel aryl amides as selective or dual NK(1)/NK(2) antagonists.
Shih
Neng Yang
NY
Schering-Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ 07033-1300, USA. neng-yang.shih@spcorp.com
Albanese
Margaret
M
Anthes
John C
JC
Carruthers
Nicholas I
NI
Grice
Cheryl A
CA
Lin
Ling
L
Mangiaracina
Pietro
P
Reichard
Gregory A
GA
Schwerdt
John
J
Seidl
Vera
V
Wong
Shing-Chung
SC
Piwinski
John J
JJ
D064729:Neurokinin-1 Receptor Antagonists; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D064729:Neurokinin-1 Receptor Antagonists; D010091:Oximes; D018041:Receptors, Neurokinin-2