[Tumors diagnosed in 65 patients with type I neurofibromatosis].
BACKGROUND
Type 1 neurofibromatosis patients develop malignant neoplasm more frequently than general population.


METHODS
We have studied 65 patients with neurofibromatosis type 1 because we intend to know the kind of neoplasms that they have presented.


RESULTS
65 patients (48 men and 17 women) fulfilling type 1 neurofibromatosis criteria have been studied. Globally 67 tumors appeared, from which 47 (70%) were benign and 20 (30%) were malignant. Benign tumors included 25 neurofibromas, 11 central nervous system tumors and 11 extraneurological tumors. Malignant tumors accounted for 6 soft tissue sarcomas, 6 carcinomas, 3 malignant CNS tumors and 2 acute lymphoblastic leukemias.


CONCLUSIONS
Presentation of neoplasms is frequent in type 1 neurofibromatosis and constitutes main death and morbility cause.
Ortiz
M
M
Servicio de Medicina Interna, Hospital General Universitario Valle de Hebrón, Barcelona.
Falcó
V
V
Sánchez
L
L
Ruiz
E
E
Cervera
C
C
Alegre
J
J
Fernández de Sevilla
T
T
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000473:pathology*