title: Papillary carcinoma in thyroglossal duct cyst.
abstract: OBJECTIVE
  To report the management and outcome of three cases of papillary carcinoma (PC) in thyroglossal duct cysts (TGCs).
  
  
  METHODS
  We present case reports of one female and two male patients between the ages of 22 and 46 years who had TGCs. In addition, we discuss the theories about the pathogenesis of TGC carcinoma (de novo versus metastatic lesions).
  
  
  RESULTS
  In all three patients, we found a TGC that contained a vegetating mass. Subsequent pathologic examination revealed the presence of a PC. All patients underwent total thyroidectomy, and two of them concurrently had PC in the thyroid gland. Besides the PC in the TGC, the first patient had a "cold" scintigraphic thyroid nodule that was also a PC, whereas the second patient had a thyroid microcarcinoma that had not been detected before surgical intervention. The third patient did not have carcinoma of the thyroid, but the histologic pattern of the gland resembled that observed in de Quervain's disease. We interpreted this finding as "palpation thyroiditis." The patients received postoperative 131I and suppressive therapy with levothyroxine. During a follow-up period of 2 to 12 years (mean, 5.8), we found no recurrence of the disease, and serum thyroglobulin remained undetectable in all cases.
  
  
  CONCLUSIONS
  Although use of total thyroidectomy followed by radioiodine therapy and suppressive treatment with levothyroxine is a matter of debate in patients with PC in TGCs, we conclude that this approach yields a favorable outcome in most cases, especially when the thyroid is also involved by the PC, and allows a better postoperative follow-up.
authors.affiliation: Division of Endocrinology, Hospital de Clínicas, José de San Martín School of Medicine, University of Buenos Aires, Argentina.
authors.forename: D
authors.initials: D
authors.lastname: Moncet
authors.forename: M
authors.initials: M
authors.lastname: Manavela
authors.forename: G E
authors.initials: GE
authors.lastname: Cross
authors.forename: E
authors.initials: E
authors.lastname: Cazado
authors.forename: J
authors.initials: J
authors.lastname: Soutelo
authors.forename: B
authors.initials: B
authors.lastname: Elsner
authors.forename: H
authors.initials: H
authors.lastname: Niepomniszcze
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013954:Thyroglobulin / Q000097:blood; D013955:Thyroglossal Cyst / Q000473:pathology* / Q000601:surgery; D013961:Thyroid Gland / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D007457:Iodine Radioisotopes; D013954:Thyroglobulin; D013974:Thyroxine