title: Freehand ultrasound elastography of breast lesions: clinical results.
abstract: We developed a freehand method for ultrasound elastography, which can be applied during a routine sonographic examination with off-line calculation of strain images (elastograms). Forty-eight patients with 53 breast lesions were examined and, after biopsy or operation, histologic reports were available for all lesions. The correlation coefficient of time delay estimates was used as a quality criterion for the subsequent calculation of elastograms. Beyond the qualitative evaluation of elastograms, we suggested a semiquantitative approach. For that purpose, the elastogram of each lesion was normalized to an overall strain of 1% (i.e., the average strain in the image was set to 1%). After normalization, we determined mean strain values inside and outside of each lesion, respectively. Defining solid lesions as benign and malignant lesions except for fibrous mastopathy, we found significant difference in strain between solid lesions and their surrounding tissue. However, that result must not be misunderstood to suggest that it was possible to distinguish benign from malignant lesions in general. Still, we address the potential of ultrasound elastography to improve the detection and localization of breast lesions as well as their differential diagnosis. Besides, we developed a freehand applicator for further studies, which guarantees a homogeneous axial compression regardless of the experience of the examiner.
authors.affiliation: Department of Electrical Engineering, Ruhr University Bochum, Gebause IC 6/40, 44780 Bochum, Germany. karsten.hiltawsky@ruhr-uni-bochum.de
authors.forename: K M
authors.initials: KM
authors.lastname: Hiltawsky
authors.forename: M
authors.initials: M
authors.lastname: Krüger
authors.forename: C
authors.initials: C
authors.lastname: Starke
authors.forename: L
authors.initials: L
authors.lastname: Heuser
authors.forename: H
authors.initials: H
authors.lastname: Ermert
authors.forename: A
authors.initials: A
authors.lastname: Jensen
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D010173:Palpation; D016217:Ultrasonography, Mammary / Q000379:methods*