5-FU improves p27-related poor prognosis in patients with Astler-Coller B2-C colorectal carcinoma.
p27kip1 induces cell cycle arrest at the G1-S transition. To investigate the effect of UFT on the prognosis of colorectal cancer with respect to p27kip1 expression, survival curves of patients with p27kip1 overexpression (group A) and without p27kip1 expression (group B) were evaluated following chemotherapy using UFT (tegafur and uracil). Although there was no significant overall survival difference between group A and B patients, the patients without p27kip1 expression had a significantly lower survival rate when they did not receive UFT treatment. UFT, 5-FU masked compound may improve the p27-related poor prognosis in colorectal cancer patients.
Kobayashi
Minako
M
Second Department of Surgery, Mie University Medical School, Mie 514-8507, Japan.
Shiraishi
Taizo
T
Tonouchi
Hitoshi
H
Miki
Chikao
C
Kusunoki
Masato
M
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018797:Cell Cycle Proteins / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D050760:Cyclin-Dependent Kinase Inhibitor p27; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D005641:Tegafur / Q000627:therapeutic use; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D014498:Uracil / Q000627:therapeutic use
D018797:Cell Cycle Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil