title: Familial clustering of intracerebral hemorrhage: a prospective study in North Carolina.
abstract: Few studies have assessed the frequency of familial clustering in intracerebral hemorrhage (ICH). Of 144 patients with ICH prospectively assessed, 14 (9.8%) had a positive family history of ICH (FH+). Four pedigrees had more than two affected family members. Comparisons between FH+ and FH- probands demonstrated no significant differences in race, age, sex, ICH type or location. An underlying genetic etiology may account for familial clustering in some ICH patients.
authors.affiliation: Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Alberts
authors.forename: M O
authors.initials: MO
authors.lastname: McCarron
authors.forename: K L
authors.initials: KL
authors.lastname: Hoffmann
authors.forename: C
authors.initials: C
authors.lastname: Graffagnino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020144:Basal Ganglia Cerebrovascular Disease / Q000453:epidemiology / Q000235:genetics; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000235:genetics*; D016000:Cluster Analysis; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009657:North Carolina; D010375:Pedigree; D011446:Prospective Studies; D012307:Risk Factors