Clinical ergotism induced by ritonavir.
Ritonavir strongly inhibits cytochrome P450, thus altering the metabolism of other drugs. We report on an HIV-positive man who, on his 13th day of ritonavir therapy, developed severe ergotism after self-administration of low doses of ergotamine. Drug interactions, the degree of responsibility of the patient and the availability of over-the-counter medications must be considered when prescribing antiretroviral therapy.
Vila
A
A
Department of Internal Medicine, CEMIC, Norberto Quirno, Buenos Aires, Argentina.
Mykietiuk
A
A
Bonvehì
P
P
Temporiti
E
E
Urueña
A
A
Herrera
F
F
D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004878:Ergotamine / Q000009:adverse effects*; D004881:Ergotism / Q000209:etiology*; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D008297:Male; D019438:Ritonavir / Q000009:adverse effects*
D018712:Analgesics, Non-Narcotic; D017320:HIV Protease Inhibitors; D019438:Ritonavir; D004878:Ergotamine