title: Idiotype and anti-idiotype specific T cell responses on transplantation with hybridomas reactive to viral hemagglutinin and human tumor antigen.
abstract: B cell hybridomas expressing class I and II MHC molecules and producing antibodies directed against hemagglutinin protein of Rinderpest virus and human Mucin-1 have been used as surrogate B cells to study T cell responses against the antigens. The observed CTL and lymphoproliferative response indicates that anti-idiotypic B cells termed Jerne cells stimulate both T helper and T cytotoxic cells by virtue of their ability to present recycled or regurgitated peptido-mimics of antigen to T helper cells through class II MHC and de novo synthesized peptido-mimics of antigens to CTLs. Thus, T cell memory response can be perpetuated by anti-idiotypic Jerne B cells and these findings lend support to the earlier proposed relay hypothesis for perpetuation of immunological memory (IM).
authors.affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Shibani
authors.initials: S
authors.lastname: Mitra-Kaushik
authors.forename: M S
authors.initials: MS
authors.lastname: Shaila
authors.forename: Anjali
authors.initials: A
authors.lastname: Karande
authors.forename: Rabindranath
authors.initials: R
authors.lastname: Nayak
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D017690:Cell Transplantation; D000939:Epitopes / Q000276:immunology*; D006389:Hemagglutinins, Viral / Q000276:immunology*; D006801:Humans; D006825:Hybridomas / Q000276:immunology* / Q000637:transplantation*; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm; D000939:Epitopes; D006389:Hemagglutinins, Viral