IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis.
In this study, we investigated the in vitro proliferative response of peripheral blood T lymphocytes from MS patients and controls to MBP and MOG either in the absence or in the presence of the conditioning factor IL-7. In the absence of IL-7, T-cell reactivity to MOG and MBP was similar in MS patients and controls even if an increased MBP response was found in a subgroup of patients with active disease. In the presence of IL-7, increased T-cell reactivity to MBP was observed in MS patients suggesting that their MBP-specific T cells are in a different functional state.
Traggiai
E
E
Department Neurological and Psychiatric Sciences, Viale Pieraccini 6, 50134, Florence, Italy. neuroimm@cesit1.unifi.it
Biagioli
T
T
Rosati
E
E
Ballerini
C
C
Mazzanti
B
B
Ben Nun
A
A
Massacesi
L
L
Vergelli
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D015851:Interleukin-7 / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000276:immunology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology / Q000494:pharmacology*; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology / Q000494:pharmacology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D015851:Interleukin-7; C571326:MOG protein, human; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein