[Importance of the CRH (corticotropin releasing hormone) test in the differential diagnosis of Cushing's syndrome].
In the group of 13 patients with Cushing's syndrome (CS) CRH test was performed by sampling the blood from peripheral vein and in eight patients also after inferior petrosal sinus catheterization (IPSC) to resolve the disease etiology. In the group of patients with Cushing's disease (CD, n = 11), which was proven by surgery and adenoma immunohistochemistry, 10/11 had in CRH test the significant increase of cortisol and ACTH in the peripheral blood. Among two patients with ectopic ACTH syndrome one had the significant increase of both hormones in CRH test. After IPSC the ratio of ACTH in the petrosal sinus and in the peripheral vein was significant in 4/8 patients before, and in 6/8 after CRH administration. The intersinus gradient was significant in 3/8 patients before, and in 4/8 after CRH test. According to our results we can conclude that the determination of ACTH in the blood from peripheral veins after CRH administration is a very sensitive method for differential diagnosis of CS, while the results after IPSC were less sensitive in our conditions than those described in the literature.
Korsić
M
M
Zavod za endokrinologiju i bolesti metabolizma, Klinika za unutrasnje bolesti Medicinskog fakulteta i Klinickog bolnickog centra, Zagreb.
Plavsić
V
V
Besenski
N
N
Skorić
T
T
Giljević
Z
Z
Zarković
K
K
Zarković
N
N
Zaninović
L
L
Paladino
J
J
Aganović
I
I
D000182:ACTH Syndrome, Ectopic / Q000150:complications / Q000175:diagnosis; D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000175:diagnosis; D018246:Adrenocortical Adenoma / Q000150:complications / Q000175:diagnosis; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D003346:Corticotropin-Releasing Hormone; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017591:Petrosal Sinus Sampling; D012680:Sensitivity and Specificity
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone