Pharmacokinetics of ethanol in mice with different alcohol motivation.
We studied the pharmacokinetics of (14)C-ethanol administered in various doses and via different routes to CBA, C57Bl/6, and (CBAxC57Bl/6)F1 mice. Kinetic scheme of ethanol distribution included its elimination by enzymatic (80-90% C(0)) and exponential (10-20% C(0)) mechanisms. Ethanol pharmacokinetics did not depend on the administration route and mouse strain. The kinetic scheme of ethanol distribution in mice was characterized by a dose-dependent linear increase in alcohol concentration in the plasma and brain and nonlinear (parabolic) increase in the area under its pharmacokinetic curve in the test tissue.
Golovenko
N Y
NY
I. I. Mechnikov Odessa National University.
Zhuk
M S
MS
Zin'kovskii
V G
VG
Zhuk
O V
OV
Kopanitsa
M V
MV
D000428:Alcohol Drinking; D000818:Animals; D019540:Area Under Curve; D001921:Brain / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000493:pharmacokinetics*; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors
D002492:Central Nervous System Depressants; D000431:Ethanol