title: Effect of multipolar electrocoagulation on EUS findings in Barrett's esophagus.
abstract: BACKGROUND
  Restoration of squamous epithelium in patients with Barrett's epithelium may be achieved by treatment with a proton pump inhibitor plus selective electrocoagulation of the metaplastic epithelium. The effect of such treatment on esophageal wall thickness and morphology, as determined by EUS, is unknown.
  
  
  METHODS
  Patients with Barrett's esophagus were treated with omeprazole (40 mg by mouth, twice daily) and underwent selective multipolar electrocoagulation of the metaplastic segment monthly until complete squamous re-epithelialization or a maximum of 6 treatments was achieved. EUS was performed before and 6 months after the end of treatment. Four-quadrant large-forceps biopsy specimens were taken every 2 cm at the 6-month follow-up.
  
  
  RESULTS
  Twenty-five patients with Barrett's epithelium (mean length 3.1 cm, range 2-6 cm) were included. Complete endoscopic reversal was achieved in 24 patients. Residual intestinal metaplasia beneath squamous epithelium was observed in 1 patient. In 4 patients there was intestinalized mucosa at the neosquamocolunmar junction. The thickness of the treated distal esophageal wall decreased from 4.0 +/- 0.1 mm to 3.7 +/- 0.1 mm (mean +/- SEM; p < 0.05, 2-tailed paired t test). Untreated (control) esophageal wall thickness at the level of the aortic arch (2.1 +/- 0.1 mm vs. 2.2 +/- 0.1 mm) and the mid-body gastric wall thickness (2.9 +/- 0.1 mm vs. 3.1 +/- 0.1 mm) did not change. Among the 6 patients with residual intestinal metaplasia there was no change in mean wall thickness (3.7 +/- 0.2 mm vs. 3.8 +/- 0.2 mm); among the 19 without metaplasia, thickness decreased from 4.1 +/- 0.2 mm to 3.6 +/- 0.2 mm; p < 0.01. Of 11 patients with a decrease in wall thickness, only 1 had residual intestinal metaplasia. No changes in the 5-layer sonographic pattern of the esophageal wall were observed.
  
  
  CONCLUSIONS
  Multipolar electrocoagulation of Barrett's esophagus results in a slight decrease in thickness of the treated esophageal wall. A decrease in wall thickness by EUS was associated with the absence of intestinal metaplasia in follow-up biopsy specimens.
authors.affiliation: Portland VA Medical Center, Oregon Health and Science University, Portland, Oregon, 97201, USA.
authors.forename: Douglas O
authors.initials: DO
authors.lastname: Faigel
authors.forename: David A
authors.initials: DA
authors.lastname: Lieberman
authors.forename: Wilfred M
authors.initials: WM
authors.lastname: Weinstein
authors.forename: Shane
authors.initials: S
authors.lastname: Fanning
authors.forename: M Brian
authors.initials: MB
authors.lastname: Fennerty
authors.forename: Richard B
authors.initials: RB
authors.lastname: Sampliner
mesh_terms: D001471:Barrett Esophagus / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D004564:Electrocoagulation; D019160:Endosonography; D004848:Epithelium / Q000000981:diagnostic imaging; D004945:Esophagoscopy; D004947:Esophagus / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D054328:Proton Pump Inhibitors
chemical_list: D054328:Proton Pump Inhibitors; D009853:Omeprazole