title: 19F-MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation.
abstract: A method for in vivo measurement of oxygen partial pressure (pO2) in porcine lungs during partial liquid ventilation (PLV) with perflubron (PFOB) was developed. A pulse sequence for high-resolution MRI of the distribution of PFOB in the lung after intratracheal administration was developed as well. Moreover, quantitative measurements of longitudinal relaxation time T(1) of (19)F resonances for assessment of regional pO2 are described. Due to the need to acquire data during a single expiratory breathhold, only low SNRs were achieved in vivo. Therefore, simulations were performed to investigate the influence of background noise on T(1) values calculated from data with low SNR. Based on these simulations, a postprocessing strategy was developed to correct for systematic errors by background noise prior to quantitative analysis. Results of a pilot study in pigs under conditions of PLV are presented.
authors.affiliation: Department of Radiology, Johannes Gutenberg-University, Mainz, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Laukemper-Ostendorf
authors.forename: Alexander
authors.initials: A
authors.lastname: Scholz
authors.forename: Katja
authors.initials: K
authors.lastname: Bürger
authors.forename: Claus P
authors.initials: CP
authors.lastname: Heussel
authors.forename: Marc
authors.initials: M
authors.lastname: Schmittner
authors.forename: Norbert
authors.initials: N
authors.lastname: Weiler
authors.forename: Klaus
authors.initials: K
authors.lastname: Markstaller
authors.forename: Balthasar
authors.initials: B
authors.lastname: Eberle
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
authors.forename: Michael
authors.initials: M
authors.lastname: Quintel
authors.forename: Manfred
authors.initials: M
authors.lastname: Thelen
authors.forename: Wolfgang G
authors.initials: WG
authors.lastname: Schreiber
mesh_terms: D000818:Animals; D003287:Contrast Media; D004655:Emulsions; D005461:Fluorine; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D021061:Liquid Ventilation; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D010100:Oxygen; D010313:Partial Pressure; D013552:Swine
chemical_list: D003287:Contrast Media; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D005461:Fluorine; C003072:perflubron; D010100:Oxygen