title: Proton release as a modulator of presynaptic function.
abstract: In this issue of Neuron, DeVries (2001) describes experiments suggesting that acidification of the synaptic cleft can reduce Ca2+ channel activity and thereby act as a brake on tonic synaptic release of glutamate from cone cells. This work hints at a potentially important new facet to the regulation of synaptic transmission.
authors.affiliation: Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA.
authors.forename: S F
authors.initials: SF
authors.lastname: Traynelis
authors.forename: M
authors.initials: M
authors.lastname: Chesler
mesh_terms: D000818:Animals; D017729:Presynaptic Terminals / Q000502:physiology*; D011522:Protons; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D011522:Protons