Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium.
OBJECTIVE
To investigate the anti-implantation mechanism of mifepriston.


METHODS
In situ hybridization and immunohistochemistry were applied to determine mRNA and protein.


RESULTS
After mifepriston injection, the number of implantation sites were obviously reduced, mifepriston could inhibit the embryo implantation in mouse. The expression of apoptosis related genes, Fas and FasL, in mouse endometrium was also decreased after mifepriston treatment.


CONCLUSIONS
The expression of apoptosis related genes Fas and FasL is regulated by mifepriston and the inhibitory effect of mifepriston on the embryo implantation may be mediated by action on the Fas/FasL system.
Gao
F
F
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China.
Xu
F H
FH
Zhou
X C
XC
Han
X B
XB
Liu
Y X
YX
D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D010064:Embryo Implantation / Q000187:drug effects; D004717:Endometrium / Q000166:cytology / Q000378:metabolism*; D053222:Fas Ligand Protein; D005260:Female; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics; D019014:fas Receptor / Q000096:biosynthesis* / Q000235:genetics
D000021:Abortifacient Agents, Steroidal; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D019014:fas Receptor; D015735:Mifepristone