Somatostatin- and Substance P-ergic neurons and Glial cell line-derived neurotrophic factor in the human archicortex.
By means of immunohistochemistry, the localization of Somatostatin (SOM)- and Substance P (SP)-ergic neuronal populations was compared to the occurrence of Glial cell line-derived neurotrophic factor (GDNF) in the human hippocampus from prenatal to adult life stages. The results obtained i) confirm previous reports on the distribution of SOM and SP; ii) show that GDNF-like immunoreactivity occurs in an ample population of hippocampal neurons, with a main location in the pyramidal cells; iii) identify regions of codistribution of either neuropeptide with GDNF-positive elements. Although coexistence of GDNF with SOM or SP was not detected, the possibility that the trophic factor may act on the neuropeptide-containing neurons can be envisaged and is worth further analysis.
Quartu
M
M
Department of Cytomorphology, University of Cagliari, Italy.
Serra
M P
MP
Bachis
A
A
Del Fiacco
M
M
D000328:Adult; D000375:Aging / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D005333:Fetus; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006624:Hippocampus / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism / Q000648:ultrastructure; D017966:Pyramidal Cells / Q000166:cytology / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D013373:Substance P; D013004:Somatostatin