title: The cream dilution gene, responsible for the palomino and buckskin coat colours, maps to horse chromosome 21.
abstract: The colour locus historically referred to as C in the horse is linked to microsatellites markers on horse chromosome 21. Preliminary results demonstrated linkage of Ccr, thought to be the cream dilution variant of the C locus, to HTG10. An analysis of horse chromosome 21 using additional families confirmed and established a group of markers linked to Ccr. This work also improved the resolution of previously reported linkage maps for this chromosome. Linkage analysis unambiguously produced the map order: SGCV16-(19.1 cM)-HTG10-(3.8 cM)-LEX60/COR73-(1.3 cM)-COR68-(4.5 cM)- Ccr-(11.9 cM)-LEX31. Comparative and synteny data suggested that the horse C locus is not tyrosinase (TYR).
authors.affiliation: Veterinary Genetics Laboratory, University of California, Davis, CA, USA. mmlocke@ucdavis.edu
authors.forename: M M
authors.initials: MM
authors.lastname: Locke
authors.forename: L S
authors.initials: LS
authors.lastname: Ruth
authors.forename: L V
authors.initials: LV
authors.lastname: Millon
authors.forename: M C
authors.initials: MC
authors.lastname: Penedo
authors.forename: J D
authors.initials: JD
authors.lastname: Murray
authors.forename: A T
authors.initials: AT
authors.lastname: Bowling
mesh_terms: D000818:Animals; D002874:Chromosome Mapping / Q000662:veterinary*; D005260:Female; D006200:Hair Color / Q000235:genetics*; D006736:Horses / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats