title: Reproductive outcomes in women with congenital uterine anomalies detected by three-dimensional ultrasound screening.
abstract: OBJECTIVE
  To determine reproductive outcomes in women with congenital uterine anomalies detected incidentally by three-dimensional ultrasound.
  
  
  METHODS
  We studied 1089 women with no history of infertility or recurrent miscarriage who were seen for a transvaginal ultrasound scan. They were screened for uterine abnormalities using three-dimensional ultrasound. We determined prevalence of miscarriage and preterm labor in women with normal and abnormal uterine morphology.
  
  
  RESULTS
  We found that 983 women had a normally shaped uterine cavity, 72 an arcuate, 29 a subseptate, and five a bicornuate uterus. Women with a subseptate uterus had a significantly higher proportion of first-trimester loss (Zeta = 4.68, P <.01) compared with women with a normal uterus. Women with an arcuate uterus had a significantly greater proportion of second-trimester loss (Zeta = 5.76, P <.01) and preterm labor (Zeta = 4.1, P <.01). There were no other significant differences in pregnancy outcomes between women with normal and abnormal uterine morphology.
  
  
  CONCLUSIONS
  This study shows the potential value of three-dimensional ultrasound and confirmed that women with congenital uterine anomalies were more likely to have adverse pregnancy outcomes than women with a normal uterus.
authors.affiliation: Early Pregnancy & Gynaecology Assessment Unit,King's College Hospital, London, United Kingdom.
authors.forename: B
authors.initials: B
authors.lastname: Woelfer
authors.forename: R
authors.initials: R
authors.lastname: Salim
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
authors.forename: J
authors.initials: J
authors.lastname: Elson
authors.forename: L
authors.initials: L
authors.lastname: Regan
authors.forename: D
authors.initials: D
authors.lastname: Jurkovic
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D005260:Female; D006801:Humans; D008131:London / Q000453:epidemiology; D007752:Obstetric Labor, Premature / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal; D014599:Uterus / Q000002:abnormalities* / Q000000981:diagnostic imaging*