Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates.
A new series of quinolone-platinum(II) conjugates, [Pt(Q'-NH2)(dmso)X2] and cis-[Pt(Q"-en)X2], where Q' and Q" are quinolones (flumequine, nalidixic acid or oxolinic acid) linked to monodentate and bidentate amine ligands, respectively, and X2 is Cl2 or 1,1-cyclobutanedicarboxylate, have been synthesized with the aim of examining the synergetic antitumor activity of quinolone intercalation and platinum(II) chelation. The complexes were characterized by elemental analyses and IR and multinuclear (1H and 195Pt) NMR spectroscopies, and then subjected to in vitro and in vivo bioassays using the leukemia L1210 cell line.
Kim
Y S
YS
Department of Chemistry, Ewha Womans University, 120-750, Seoul, South Korea.
Kim
K M
KM
Song
R
R
Jun
M J
MJ
Sohn
Y S
YS
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D016190:Carboplatin / Q000494:pharmacology; D024841:Fluoroquinolones; D007939:Leukemia L1210; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D015394:Molecular Structure; D009268:Nalidixic Acid / Q000737:chemistry; D010093:Oxolinic Acid / Q000737:chemistry; D010984:Platinum / Q000737:chemistry* / Q000494:pharmacology; D011807:Quinolizines / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D024841:Fluoroquinolones; D011807:Quinolizines; D015363:Quinolones; D009268:Nalidixic Acid; D010984:Platinum; D016190:Carboplatin; D010093:Oxolinic Acid; C012976:flumequine