title: Discontinuation of secondary prophylaxis in patients with cytomegalovirus retinitis who have responded to highly active antiretroviral therapy.
abstract: We performed a prospective study of discontinuation of secondary prophylaxis against cytomegalovirus (CMV) in 36 patients with acquired immunodeficiency syndrome and quiescent CMV retinitis after successful treatment with highly active antiretroviral therapy (HAART). No reactivation or progression of retinitis was observed in 35 patients with persistent response to HAART, findings that support the discontinuation of secondary prophylaxis against CMV retinitis in such patients.
authors.affiliation: Services of Infectious Diseases , Hospital Gregorio Marañón, 28007, Madrid, Spain. juaberber@eresmas.net
authors.forename: Juan
authors.initials: J
authors.lastname: Berenguer
authors.forename: Juan
authors.initials: J
authors.lastname: González
authors.forename: Federico
authors.initials: F
authors.lastname: Pulido
authors.forename: Belén
authors.initials: B
authors.lastname: Padilla
authors.forename: José Luis
authors.initials: JL
authors.lastname: Casado
authors.forename: Rafael
authors.initials: R
authors.lastname: Rubio
authors.forename: José Rarmón
authors.initials: JR
authors.lastname: Arribas
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology / Q000821:virology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018890:Chemoprevention; D015331:Cohort Studies; D017726:Cytomegalovirus Retinitis / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies