title: Phenytoin hypersensitivity syndrome.
abstract: Phenytoin hypersensitivity syndrome (PHS) is a rare, and important entity characterized by rash, fever, lymphadenopathy, leukocytosis with atypical lymphocytes, eosinophilia and associated hepatitis. In this article, we present the clinical, laboratory and histopathologic results of 5 cases of PHS. In therapy, pheyntoin was stopped and sodium valproate (10-20 mg/kg day) was started. Additionally, prednisolone was given in two patients who had not resolved eruption with conservative therapy.
authors.affiliation: Department of Dermatology, Ankara Numune Hospital, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Güngör
authors.forename: N
authors.initials: N
authors.lastname: Alli
authors.forename: S
authors.initials: S
authors.lastname: Comoğlu
authors.forename: C
authors.initials: C
authors.lastname: Cömcüoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000150:complications / Q000473:pathology*; D004802:Eosinophilia / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D005260:Female; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin