Differential role for the striatum and cerebellum in response to novel movements using a motor learning paradigm.
The aim of this pilot study was to examine the role of the striatum and cerebellum in the adaptation to a novel movement within a sequence of practiced movements using a motor learning paradigm. The performance of patients in the early or advanced stages of Parkinson's disease (PD) and of patients with damage to the cerebellum (CE) was compared, respectively to a group of aged and young matched controls on an adapted version of the Mirror-Tracing Test. In this task, subjects were required to trace a series of complex figures in two conditions: (1) a Practiced condition, in which the figures were composed of the juxtaposition of three simple designs that were extensively practiced before; and (2) a Mixed condition in which triads were created by replacing the last simple figure of the triads in the Practiced condition by a new simple figure that had never been traced individually before. Results showed that all clinical groups were slower than controls at tracing the Practiced triads. Most interestingly, however, only patients in the advanced stages of PD showed increased completion time to trace the triads in the Mixed condition. This suggests that a bilateral striatal dysfunction affects the ability to adapt to a novel motion within a sequence of practiced movements. Although exploratory, these results support a functional dissociation between the striatum and cerebellum in acquiring visuomotor skilled behaviors.
Laforce
Robert
R
Department of Psychology, University of New Brunswick, P.O. Box 5050, Saint John, NB, Canada E2L4L5. rlaforce@unbsj.ca
Doyon
Julien
J
D000328:Adult; D000368:Aged; D000375:Aging / Q000523:psychology*; D016022:Case-Control Studies; D002526:Cerebellar Diseases / Q000503:physiopathology / Q000523:psychology*; D002531:Cerebellum / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D008875:Middle Aged; D017072:Neostriatum / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology*; D011214:Practice, Psychological; D011597:Psychomotor Performance; D012720:Severity of Illness Index