title: Aspiration: a factor in rapidly deteriorating bronchiolitis in previously healthy infants?
abstract: The objective of this study was to evaluate the presence of indicators of aspiration in previously healthy infants with respiratory syncytial viral (RSV) bronchiolitis who experienced rapid deterioration in their respiratory status. Lipid-laden macrophage index (LLMI) was assessed in 6 previously healthy infants with RSV bronchiolitis and no prior history of aspiration, who had a rapid deterioration of their respiratory status requiring mechanical ventilation. Five of 6 infants had a LLMI of more than 100, a level that is very suggestive of aspiration. We conclude that aspiration is likely to play a role when rapid deterioration occurs in infants with RSV bronchiolitis.
authors.affiliation: North Shore Regional Medical Center and West Jefferson Medical Center, New Orleans, Louisiana.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hernandez
authors.forename: Vikram
authors.initials: V
authors.lastname: Khoshoo
authors.forename: Dipu
authors.initials: D
authors.lastname: Thoppil
authors.forename: Dean
authors.initials: D
authors.lastname: Edell
authors.forename: Gerald
authors.initials: G
authors.lastname: Ross
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001990:Bronchiolitis, Viral / Q000150:complications / Q000503:physiopathology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D006801:Humans; D007223:Infant; D001239:Inhalation; D008055:Lipids / Q000032:analysis; D016676:Macrophages, Alveolar / Q000737:chemistry; D008297:Male; D011446:Prospective Studies; D012121:Respiration, Artificial; D018357:Respiratory Syncytial Virus Infections / Q000150:complications / Q000503:physiopathology* / Q000628:therapy
chemical_list: D015415:Biomarkers; D008055:Lipids