A status report on the sequencing and annotation of the P. falciparum genome.
Almost 5 years ago, an international consortium of sequencing centers and funding agencies was formed to sequence the genome of the human malaria parasite Plasmodium falciparum. A novel chromosome by chromosome shotgun strategy was devised to sequence this very AT-rich genome. Two of the 14 chromosomes have been completed and the remaining chromosomes are in the final stages of gap closure. The consortium recently developed plans for the annotation and analysis of the complete genome sequence and its publication in 2002.
Gardner
M J
MJ
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. gardner@tigr.org
D000818:Animals; D002875:Chromosomes / Q000235:genetics; D018503:Genome, Protozoan; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods*