title: Recombinant factor VIIa (Novoseven) and the safety of treatment.
abstract: Recombinant factor VIIa (rFVIIa; NovoSeven), Novo Nordisk, Bagsvaerd, Denmark) has been used to treat more than 6,500 patients with hemophilia or other bleeding disorders, and by May 2001, more than 180,000 standard doses had been administered. Clinical experience to date suggests that rFVIIa is safe and effective, with a very low incidence of thrombotic events being reported. Moreover, in the majority of cases, thrombotic events appear to be caused by improvements in the hemostatic system, rather than a direct effect of the agent itself.
authors.affiliation: University of North Carolina, Chapel Hill, NC, USA.
authors.forename: H R
authors.initials: HR
authors.lastname: Roberts
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control; D003257:Consumer Product Safety; D005167:Factor VII / Q000009:adverse effects / Q000592:standards* / Q000627:therapeutic use; D015942:Factor VIIa; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy; D006801:Humans; D011994:Recombinant Proteins / Q000009:adverse effects / Q000592:standards* / Q000627:therapeutic use; D013927:Thrombosis / Q000209:etiology
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa