Functional tethered membranes.
Phospholipid bilayer membranes at the interface between a substrate and an aqueous phase, supported by or tethered to the solid surface via a polymer cushion, a peptide-, protein-, or oligosaccharide-coupling layer have reached a stage at which they are important as a novel model membrane system but also offer potential for practical applications (e.g. for biosensing purposes with membrane-integral receptors). We briefly summarize some of the recent progress made in the structural characterization of the build-up of these rather complex interfacial architectures, in the functionalization of the pure lipid matrix by the reconstitution of proteins, and in the lateral patterning of the membranes as a prerequisite for the construction of membrane chips for massive parallel monitoring of binding events.
Sinner
E K
EK
Max-Planck-Institut für Biochemie, Klopferspitz 18a, 82152, Martinsried, Germany.
Knoll
W
W
D008051:Lipid Bilayers / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry; D008566:Membranes / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry
D008051:Lipid Bilayers; D008565:Membrane Proteins; D010743:Phospholipids