Spaced training facilitates long-term retention of place navigation in adult but not in adolescent rats.
Young and adult Long Evans rats were tested in the water maze according to two different procedures: half of the subjects were given one session of four trials a day for 6 days, whereas the other subjects had the same amount of training massed in 1 day. For both conditions, a 14-day retention interval was then introduced to test long-term memory. This was followed by a four-trial reversal session. All groups showed a significant learning curve, but escape latencies were shorter for the adult than for the young rats, without differential effect of the training procedure. A first probe trial (PT1) confirmed similar accurate short-term retention in all the groups. But unimpaired long-term memory was only seen in the adult rats trained with the spaced procedure. The young rats trained over 1 day also showed some retention of the platform location after 14 days, but not the other two groups. Reversal acquisition of the new platform location was rapid in the four groups. These results indicate that although accurate short-term spatial memory in the water maze is seen after a 1-day massed training in both age groups, unimpaired long-term retention is only observed in adult rats trained with 24-h inter-session intervals.
Spreng
Matthieu
M
Institute of Physiology, University of Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland. matthieu.spreng@iphysiol.unil.ch
Rossier
Jérôme
J
Schenk
Françoise
F
D000375:Aging / Q000523:psychology*; D000818:Animals; D005260:Female; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D009949:Orientation / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D012193:Reversal Learning / Q000502:physiology; D013550:Swimming / Q000502:physiology