title: Outcome and management of pathological stage I endometrial carcinoma patients with involvement of the lower uterine segment.
abstract: OBJECTIVE
  The objective was to evaluate the clinicopathologic characteristics and outcome of pathologic stage I endometrial carcinoma patients with lower uterine segment (LUS) involvement.
  
  
  METHODS
  We retrospectively reviewed the characteristics and outcomes of pathologic stage I endometrial carcinoma patients treated with primary surgery at our institution between 1988 and 1998. The significance of LUS involvement was examined with univariate and multivariate analyses. Median patient follow-up was 37.3 months.
  
  
  RESULTS
  Of the 98 cases reviewed, 41 (42%) had LUS involvement. No differences were seen in the clinicopathologic features, extent of surgical staging, or adjuvant therapies between patients with and without LUS involvement. Univariate analysis revealed that grade, lymphovascular invasion (LVI), myometrial invasion (MI), and histology were correlated with recurrence. While the 5-year actuarial disease-free survival was worse in women with LUS involvement (80.3 vs 94.0%) compared to those without, this difference did not reach statistical significance (P = 0.14). Moreover, after controlling for pathologic features in a multivariate model, LUS involvement was not correlated with patient outcome (P = 0.98; hazard rate 0.97; 95% confidence interval 0.24, 4.0). LUS was also not correlated with pelvic recurrence. Of 25 low-risk patients (superficial MI and grade 1-2 disease) with LUS involvement, none recurred in the pelvis following surgery alone. In contrast, pelvic recurrence was common (5/12 or 41.6%) in high-risk patients (deep MI and/or grade 3 tumors) following surgery alone regardless of LUS involvement.
  
  
  CONCLUSIONS
  LUS involvement is common in pathologic stage I endometrial carcinoma but is not correlated with a worse outcome. Moreover, in the absence of adverse pathologic features, LUS involvement is not associated with an increased risk of pelvic recurrence and should not be used as an indication for adjuvant radiation therapy.
authors.affiliation: Departments of Obstetrics and Gynecology, University of Chicago Hospitals, Chicago, Illinois 60637, USA.
authors.forename: C
authors.initials: C
authors.lastname: Phelan
authors.forename: A G
authors.initials: AG
authors.lastname: Montag
authors.forename: J
authors.initials: J
authors.lastname: Rotmensch
authors.forename: S E
authors.initials: SE
authors.lastname: Waggoner
authors.forename: S D
authors.initials: SD
authors.lastname: Yamada
authors.forename: A J
authors.initials: AJ
authors.lastname: Mundt
mesh_terms: D000368:Aged; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome