Antifungal sordarins. Synthesis and structure-activity relationships of 3'-O-substituted derivatives.
A number of novel 3'-O-acyl and alkyl sordarins were synthesised for structure-activity relationship studies. Many of these derivatives exhibit high activity against Candida albicans, Candida pseudotropicalis, Candida tropicalis and Cryptococcus neoformans.
Arribas
Enrique M
EM
GlaxoSmithKline, Research Department, Parque Tecnológico de Madrid, Severo Ochoa, 2. 28760 Tres Cantos, Madrid, Spain.
Castro
Julia
J
Clemens
Ian R
IR
Cuevas
Juan C
JC
Chicharro
Jesús
J
Fraile
Ma Teresa
MT
García-Ochoa
Silvestre
S
Gómez de las Heras
Federico
F
Ruiz
José R
JR
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D007192:Indenes; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D007192:Indenes; C003329:sordarin