Mapping quantitative trait Loci using generalized estimating equations.
A number of statistical methods are now available to map quantitative trait loci (QTL) relative to markers. However, no existing methodology can simultaneously map QTL for multiple nonnormal traits. In this article we rectify this deficiency by developing a QTL-mapping approach based on generalized estimating equations (GEE). Simulation experiments are used to illustrate the application of the GEE-based approach.
Lange
C
C
School of Applied Statistics, University of Reading, Reading RG6 6FN, United Kingdom. clange@hsph.harvard.edu
Whittaker
J C
JC
D000465:Algorithms; D002874:Chromosome Mapping; D003198:Computer Simulation; D005838:Genotype; D008957:Models, Genetic; D015233:Models, Statistical; D019655:Quantitative Trait, Heritable