title: Hypotensive effect of chemical constituents from Aloe barbadensis.
abstract: Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of elgonica dimer A (1).
authors.affiliation: Dr. H.M.I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan. rs127pk@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Saleem
authors.forename: S
authors.initials: S
authors.lastname: Faizi
authors.forename: B S
authors.initials: BS
authors.lastname: Siddiqui
authors.forename: M
authors.initials: M
authors.lastname: Ahmed
authors.forename: S A
authors.initials: SA
authors.lastname: Hussain
authors.forename: A
authors.initials: A
authors.lastname: Qazi
authors.forename: A
authors.initials: A
authors.lastname: Dar
authors.forename: S I
authors.initials: SI
authors.lastname: Ahmad
authors.forename: M H
authors.initials: MH
authors.lastname: Qazi
authors.forename: S
authors.initials: S
authors.lastname: Akhtar
authors.forename: S N
authors.initials: SN
authors.lastname: Hasnain
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004642:Emodin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D028321:Plant Preparations / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats
chemical_list: D000880:Anthraquinones; D000959:Antihypertensive Agents; D005960:Glucosides; D028321:Plant Preparations; C459214:elgonica dimer A; C059635:aloe emodin anthrone; D004642:Emodin; C006457:alloin