title: Acute hormonal response to sublingual androstenediol intake in young men.
abstract: The effectiveness of orally ingested androstenediol in raising serum testosterone concentrations may be limited because of hepatic breakdown of the ingested androgens. Because androstenediol administered sublingually with cyclodextrin bypasses first-pass hepatic catabolism, we evaluated the acute hormonal response to sublingual cyclodextrin androstenediol supplement in young men. Eight men (22.9 +/- 1.2 yr) experienced in strength training consumed either 20 mg androstenediol in a sublingual cyclodextrin tablet (Sl Diol) or placebo (Pl) separated by at least 1 wk in a randomized, double-blind, crossover manner. Blood samples were collected before supplementation and at 30-min intervals for 3 h after supplementation. Serum hormone concentrations did not change with Pl. Serum androstenedione concentrations were increased (P < 0.05) above baseline (11.2 +/- 1.1 nmol/l) with Sl Diol from 60 to 180 min after intake and reached a peak concentration of 25.2 +/- 2.9 nmol/l at 120 min. Serum free testosterone concentrations were increased from 86.2 +/- 9.1 pmol/l with Sl Diol from 30 to 180 min and reached a peak concentration of 175.4 +/- 12.2 pmol/l at 60 min. Serum total testosterone concentrations increased above basal (25.6 +/- 2.3 nmol/l) from 30 to 180 min with Sl Diol and reached a peak concentration of 47.9 + 2.9 nmol/l at 60 min. Serum estradiol concentrations were elevated (P < 0.05) above baseline (0.08 +/- 0.01 nmol/l) from 30 to 180 min with Sl Diol and reached 0.14 +/- 0.02 nmol/l at 180 min. These data indicate that sublingual cyclodextrin androstenediol intake increases serum androstenedione, free testosterone, total testosterone, and estradiol concentrations.
authors.affiliation: Exercise Biochemistry Laboratory, Department of Health and Human Performance, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Brown
authors.forename: Emily R
authors.initials: ER
authors.lastname: Martini
authors.forename: B Scott
authors.initials: BS
authors.lastname: Roberts
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Vukovich
authors.forename: Douglas S
authors.initials: DS
authors.lastname: King
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D015114:Androstenediol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects; D003505:Cyclodextrins; D004032:Diet; D004958:Estradiol / Q000097:blood; D005079:Excipients; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D013739:Testosterone / Q000097:blood; D014891:Weight Lifting
chemical_list: D003505:Cyclodextrins; D005079:Excipients; D006728:Hormones; D013739:Testosterone; D004958:Estradiol; D015114:Androstenediol