title: Müllerian adenosarcoma of the cervix with heterologous elements: report of a case and review of the literature.
abstract: BACKGROUND
  Müllerian adenosarcoma (MA) is a rare neoplasm composed of benign epithelial and malignant stromal components. Its location in the cervix and the presence of heterologous elements are extremely infrequent (to our knowledge, only 14 more cases have been reported in the English literature). We describe another case of MA of the uterine cervix with heterologous elements and review the clinical and pathological features of these tumors.
  
  
  METHODS
  A nulliparous 25-year-old woman was admitted to the hospital because of metrorrhagia and recurrent masses, dependent on the cervix, initially considered endocervical polyps. Microscopically, the last curettage performed revealed a tumor composed of two elements, epithelial and mesenchymal. The epithelial elements were benign endocervical type glands, and the mesenchymal were sarcomatous, containing minor foci of cartilage. A diagnosis of endocervical heterologous adenosarcoma was reached, and a total hysterectomy and bilateral salpingo-oophorectomy were performed. The patient is alive 2 years after the surgical procedure. Neither chemotherapy nor other adjuvant therapies have been administered, and she is clinically free of disease at the moment.
  
  
  CONCLUSIONS
  Because MA with heterologous elements seems to appear at the earliest stages of the reproductive lifespan in women, commonly with a history of recurrent polyps, and because its malignant potential is uncertain, gynecologists and pathologists should be aware and think about the possibility of this tumor. Long-term follow-up is essential and so is the accumulation of individual cases to provide further experience with these unusual neoplasms.
authors.affiliation: Department of Pathology, Principe de Asturias, University Hospital, Alcala de Henares, 28805, Spain. pramos@hupa.insalud.es
authors.forename: P
authors.initials: P
authors.lastname: Ramos
authors.forename: A
authors.initials: A
authors.lastname: Ruiz
authors.forename: E
authors.initials: E
authors.lastname: Carabias
authors.forename: I
authors.initials: I
authors.lastname: Piñero
authors.forename: A
authors.initials: A
authors.lastname: Garzon
authors.forename: I
authors.initials: I
authors.lastname: Alvarez
mesh_terms: D018195:Adenosarcoma / Q000473:pathology*; D000328:Adult; D005260:Female; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*