title: Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy.
abstract: We report a patient with cyclic thrombocytopenia and antiplatelet antibodies, a variant of chronic immune thrombocytopenic purpura (ITP), with a several year history of periodic fluctuation of the platelet count, megakaryocytic hyperplasia and high-titer anti-GPIb-specific antiplatelet antibodies. The patient was resistant to multiple forms of therapy but has responded to the thrombopoietic growth factor, pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF). This case suggests that some patients with classic ITP may respond to thrombopoietic growth factors.
authors.affiliation: Baylor College of Medicine, Houston Texas, USA.
authors.forename: L
authors.initials: L
authors.lastname: Rice
authors.forename: J L
authors.initials: JL
authors.lastname: Nichol
authors.forename: R
authors.initials: R
authors.lastname: McMillan
authors.forename: L K
authors.initials: LK
authors.lastname: Roskos
authors.forename: M
authors.initials: M
authors.lastname: Bacile
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D010976:Platelet Count; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000627:therapeutic use*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D013926:Thrombopoietin / Q000008:administration & dosage* / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use*
chemical_list: D001323:Autoantibodies; D019038:Platelet Glycoprotein GPIb-IX Complex; D011994:Recombinant Proteins; C103117:polyethylene glycol-recombinant human megakaryocyte growth and development factor; D011092:Polyethylene Glycols; D013926:Thrombopoietin