RNA targets of the fragile X protein.
Three papers published recently in Cell bring the power of human genetics, Drosophila genetics, and genomics to bear on the understanding of fragile X syndrome. They provide further support for the importance of local protein synthesis within a neuron as a determinant of proper synaptogenesis and the development of cognitive abilities.
Kaytor
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Institute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Box 206, University of Minnesota Health Center, Minneapolis, MN 55455, USA.
Orr
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D000818:Animals; D006801:Humans; D020816:Amino Acid Motifs; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000502:physiology; D011485:Protein Binding; D012270:Ribosomes / Q000378:metabolism; D012313:RNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013569:Synapses / Q000502:physiology
D029721:Drosophila Proteins; D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D012313:RNA; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human