title: The prevalence of avascular necrosis in patients treated with chemotherapy for testicular tumours.
abstract: To study the prevalence of avascular necrosis in patients receiving chemotherapy for testicular cancer we invited 103 consecutive patients treated by chemotherapy to attend for MRI scan of the hips. Four of 47 (9% (CI 2-20%)) patients scanned and 4/103 (3.8% (CI 1-10%)) of patients invited to participate in the study had evidence of avascular necrosis. As not all patients in the study had completed the at risk period this equates to a 3-year actuarial risk of 6.3% (95% confidence limits (CI) 2.4-16.1). These data suggest that avascular necrosis is an uncommon but significant complication of chemotherapy including steroids as anti-emetics.
authors.affiliation: Academic Department of Radiotherapy and Oncology, The Royal Marsden NHS Trust, and Institute of Cancer Research, Downs Road, Sutton, Surrey, SM2 5PT, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Cook
authors.forename: A S
authors.initials: AS
authors.lastname: Dzik-Jurasz
authors.forename: A R
authors.initials: AR
authors.lastname: Padhani
authors.forename: A
authors.initials: A
authors.lastname: Norman
authors.forename: R A
authors.initials: RA
authors.lastname: Huddart
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004358:Drug Therapy / Q000706:statistics & numerical data; D064420:Drug-Related Side Effects and Adverse Reactions; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced* / Q000453:epidemiology; D015995:Prevalence; D011795:Surveys and Questionnaires; D013736:Testicular Neoplasms / Q000188:drug therapy*; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D001761:Bleomycin; D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin; D002945:Cisplatin