title: Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders.
abstract: It is known that the concentrations of essential fatty acids and their metabolites including eicosanoids, free radicals and anti-oxidants are altered in glomerular disorders. Both corticosteroids and n-3 fatty acids--eicosapentaenoic acid and docosahexaenoic acid (EPA and DHA respectively)--are useful in the management of glomerular disorders. In the present study, the altered plasma concentrations of lipid peroxides, nitric oxide and the metabolites of essential fatty acids and anti-oxidants--superoxide dismutase, glutathione peroxidase and vitamin E--in the RBC membranes of patients with glomerular disorders (nephrotic syndrome) reverted to normalcy following corticosteroids or EPA/DHA administration. This suggests that the beneficial actions of corticosteroids and EPA/DHA in glomerular disorders can be attributed to their action on the pro-oxidant and anti-oxidant concentrations and metabolism of essential fatty acids.
authors.affiliation: EFA Sciences LLC, Norwood, MA 02062, USA.
authors.forename: U N
authors.initials: UN
authors.lastname: Das
authors.forename: I K
authors.initials: IK
authors.lastname: Mohan
authors.forename: T R
authors.initials: TR
authors.lastname: Raju
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000097:blood; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood; D009404:Nephrotic Syndrome / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D009569:Nitric Oxide / Q000097:blood; D010084:Oxidation-Reduction / Q000187:drug effects; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000305:Adrenal Cortex Hormones; D000975:Antioxidants; D005228:Fatty Acids, Essential; D008054:Lipid Peroxides; D014810:Vitamin E; D004281:Docosahexaenoic Acids; D009569:Nitric Oxide; D015118:Eicosapentaenoic Acid; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase