title: Frequency-dependent selection in human immunodeficiency virus type 1.
abstract: Genetic variation is the main evolutionary strategy adopted by RNA viruses and retroviruses. Evolution operates through competition between different individuals in the same environment, resulting in the imposition of the fittest variant. The process of competition could be affected by various factors, including the frequency of the different competing individuals. In order to investigate this aspect, individual virus populations derived from a human immunodeficiency virus type 1 isolate were studied at different competing proportions. The dynamics of variant imposition in each competition experiment permitted the detection of frequency-dependent selection (FDS); i.e. the imposition of variants is related to their biological fitness, which is also affected by the proportions at which they compete. The existence of FDS in different viruses with RNA genomes would indicate a general mechanism favouring genetic heterogeneity.
authors.affiliation: Servicio de Virología Molecular, Centro Nacional de Biología Fundamental, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain1.
authors.forename: Eloisa
authors.initials: E
authors.lastname: Yuste
authors.affiliation: Instituto 'Cavanilles' de Biodiversidad y Biología Evolutiva and Departament de Genètica, Universitat de València Estudi General, Dr Moliner 50, Burjassot, E-46100 Valencia, Spain2.
authors.forename: Andrés
authors.initials: A
authors.lastname: Moya
authors.affiliation: Servicio de Virología Molecular, Centro Nacional de Biología Fundamental, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain1.
authors.forename: Cecilio
authors.initials: C
authors.lastname: López-Galíndez
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000704:Analysis of Variance; D019143:Evolution, Molecular; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D016014:Linear Models; D012641:Selection, Genetic; D014407:Tumor Cells, Cultured
chemical_list: D015699:HIV Envelope Protein gp120