Constructing a Golgi complex.
In this issue, Short et al. report the discovery of a protein named Golgin-45 that is located on the surface of the middle (or medial) cisternae of the Golgi complex. Depletion of this protein disrupts the Golgi complex and leads to the return of a resident, lumenal, medial Golgi enzyme to the endoplasmic reticulum. These findings suggest that Golgin-45 serves as a linchpin for the maintenance of Golgi complex structure, and offer hints as to the mechanisms by which the polarized Golgi complex is constructed.
Pfeffer
S R
SR
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA. pfeffer@cmgm.stanford.edu
D000818:Animals; D006056:Golgi Apparatus / Q000737:chemistry* / Q000648:ultrastructure*; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis*; D021381:Protein Transport / Q000502:physiology
D008565:Membrane Proteins