title: Yield and cost of individual common diagnostic tests in new primary care outpatients in Japan.
abstract: BACKGROUND
  Appropriate diagnostic testing involves considerations of cost-effectiveness. We examined the cost-effectiveness of individual tests in a panel of tests defined by the Japan Society of Clinical Pathology.
  
  
  METHODS
  We studied 540 new, symptomatic primary care outpatients with a set of 30 common diagnostic tests [the Essential Laboratory Tests (2); ELT(2) panel] for clinical evaluation and identification of occult disease. A useful result (UR) of testing was defined as a finding that contributed to a change in a physician's diagnosis or decision-making relating to a "tentative initial diagnosis" obtained from history and physical examination alone.
  
  
  RESULTS
  The ELT(2) panel testing yielded 398 URs and uncovered 261 occult diseases among 540 patients. In total, 1592 tests contributed to either UR-generation or discovery of occult disease. The cost per effective test (cost required per test that contributed to either definition of effectiveness) ranged from 108 yen (approximately 0.92 US dollars) for total cholesterol to 6200 yen (approximately 52.50 dollars) for chest x-ray. Contribution rates and the cost per effective test varied among disease categories. We restructured panel components considering the effectiveness of each test. Subsets of the ELT(2) would have improved cost-effectiveness and achieved cost savings in five of eight disease categories.
  
  
  CONCLUSIONS
  Assembly of tests based on cost-effectiveness can improve clinical efficiency and decrease total cost of panel testing for selected patient groups.
authors.affiliation: Department of Laboratory Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. yutakemu@interlink.or.jp
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Takemura
authors.forename: Haku
authors.initials: H
authors.lastname: Ishida
authors.forename: Yuji
authors.initials: Y
authors.lastname: Inoue
authors.forename: J Robert
authors.initials: JR
authors.lastname: Beck
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care / Q000191:economics*; D001774:Blood Chemical Analysis / Q000191:economics; D002648:Child; D019411:Clinical Laboratory Techniques / Q000191:economics*; D003362:Cost-Benefit Analysis; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011320:Primary Health Care / Q000191:economics*; D016482:Urinalysis / Q000191:economics