Incidence of enteric adenovirus gastroenteritis in Iranian children.
BACKGROUND
Enteric adenoviruses, i.e. adenovirus 40 (Ad40) and adenovirus 41 (Ad41), have been shown to be a substantial cause of pediatric gastroenteritis in various parts of the world, but no data are available for Iran.


OBJECTIVE
The present study was performed to determine the incidence of enteric adenoviruses in children presenting to the Children's Medical Center with gastroenteritis in Iran.


METHODS
Stool specimens from 872 children less than 7 years of age attending the Children's Medical Center in Tehran, Iran, with gastroenteritis were tested for the presence of Ad40, Ad41, and adenovirus-genus by a monoclonal antibody-based enzyme immunoassay.


CONCLUSIONS
6.7% of stool specimens contained enteric adenoviruses (3.3% Ad40 and 3.4% Ad41) and 2.0% nonenteric adenoviruses. Mean ages of Ad40, Ad41 and NEAd-positive children were 21, 19 and 29 months, respectively. Among the adenovirus-positive patients, 53.9% were male and 46.1% female. Watery diarrhea was present in 86.4% of children infected by adenoviruses. In conclusion, for the first time, we demonstrated the presence of enteric and nonenteric adenoviruses in a considerable proportion of stool samples from Iranian children with gastroenteritis.
Saderi
H
H
Department of Microbiology, Faculty of Medicine, Shahed University, Keshavarz Blvd. Dehkade Ave. No. 29, Tehran, Iran. saderih@yahoo.com
Roustai
M H
MH
Sabahi
F
F
Sadeghizadeh
M
M
Owlia
P
P
De Jong
J C
JC
D000046:Academic Medical Centers; D000256:Adenoviridae / Q000302:isolation & purification; D000257:Adenoviridae Infections / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007492:Iran / Q000453:epidemiology; D008297:Male