Wound healing activity of human placental extracts in rats.
OBJECTIVE
To study wound healing activity of the human placental extract (HPE) in rats.


METHODS
Full thickness wounds were inflicted on depilated dorsum of Charles foster rats with 8 mm Acu-punch biopsy. The HPE was applied both at topical and im routes (2.5 mL/kg). Effects were compared on the basis of physical criteria, biochemical criteria, and histopathological study with respect to untreated control, vehicle control (1.5 % benzyl alcohol), and framycetin topical treated groups.


RESULTS
Significant lowering of wound size (P<0.05), wound index (P<0.05), and number of days required for complete healing (P<0.01); significant gain in tensile strength (P<0.01); appreciable increase of tissue DNA, total protein, and collagenesis were observed in HPE treated group.


CONCLUSIONS
Human placental extract systematically helps collagenesis leading to potent healing of wounds.
Biswas
T K
TK
SN Pradhan Centre for Neurosciences, Dr BC Roy Postgraduate Institute of Basic Medical Sciences, Calcutta 700020, India.
Auddy
B
B
Bhattacharya
N P
NP
Bhattacharya
S
S
Mukherjee
B
B
D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D006801:Humans; D010924:Placental Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
D010924:Placental Extracts; D003094:Collagen; D004247:DNA