title: Gamma Knife radiosurgery as a primary surgical treatment for hypersecreting pituitary adenomas.
abstract: OBJECTIVE
  To estimate the efficacy of Gamma Knife radiosurgery (GKR) especially as a primary surgical treatment for hypersecreting pituitary adenomas.
  
  
  METHODS
  274 patients were treated with GKR. The mean tumor volume was 1.86 cm(3). The mean peripheral dose was 28.7 Gy.
  
  
  RESULTS
  223 patients were followed up for an average of 31.6 months. The dose related to the tumor growth control and endocrinological normalization was detailed and statistical analysis of the data was performed.
  
  
  CONCLUSIONS
  GKR as a primary surgical treatment for hypersecreting pituitary adenomas may be safe and effective.
authors.affiliation: Department of Neurosurgery, Hua Shan Hospital & Shanghai Gamma Knife Hospital, Shanghai, China. nanzhang@sina.com
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Pan
authors.forename: J
authors.initials: J
authors.lastname: Dai
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: E
authors.initials: E
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Cai
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000601:surgery*; D000239:Adenoma, Acidophil / Q000378:metabolism / Q000601:surgery; D000237:Adenoma, Basophil / Q000378:metabolism / Q000601:surgery; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D000368:Aged; D001971:Bromocriptine / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D006966:Hyperprolactinemia / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D007247:Infertility, Female / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010907:Pituitary Hormones / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011388:Prolactin / Q000378:metabolism; D015175:Prolactinoma / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery; D016634:Radiosurgery; D012449:Safety; D016896:Treatment Outcome
chemical_list: D010907:Pituitary Hormones; D019382:Human Growth Hormone; D001971:Bromocriptine; D000324:Adrenocorticotropic Hormone; D011388:Prolactin