title: Identification of two putative ATP-cassette genes in Encephalitozoon intestinalis.
abstract: Currently existing chemotherapeutic compounds are limited and few are effective for treating microsporidiosis. It is possible that resistance of Encephalitozoon to some drugs occurs by efflux mechanisms similar to those previously described for mammalian tumour cells, bacteria or protozoal parasites such as Plasmodium, Leishmania and Entamoeba histolytica. The data in the present study suggest that Encephalitozoon intestinalis contains at least one multidrug resistance gene. We report here two complete sequences EiABC1 and EiABC2, encoding different ATP-binding cassette genes from E. intestinalis, including a P-gp.
authors.affiliation: Medical Research 151, Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Bonafonte
authors.forename: J
authors.initials: J
authors.lastname: Stewart
authors.forename: J R
authors.initials: JR
authors.lastname: Mead
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D016054:DNA, Protozoan / Q000235:genetics*; D018432:Drug Resistance, Multiple; D016819:Encephalitozoon / Q000187:drug effects / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D015800:Protozoan Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid
chemical_list: D018528:ATP-Binding Cassette Transporters; D016054:DNA, Protozoan; D015800:Protozoan Proteins