Effect of hyperprolactinaemia as induced by pituitary homografts under kidney capsule on gastric and duodenal ulcers in rats.
The effect of hyperprolactinaemia, induced by two or four pituitary homografts under the kidney capsule, on gastric and duodenal ulcers has been studied. The acute gastric ulcer models used were pylorus ligation, indometacin-induced and ethanol-induced gastric ulcers. Chronic gastric ulcers were induced using acetic acid and duodenal ulcers by mercaptamine hydrochloride. After pylorus ligation, there was an approximate 30-40% increase in gastric secretion, a significant increase in total acidity (P < 0.01) and in the ulcer index (P < 0.01) in rats bearing pituitary homografts under the kidney capsule when compared with the sham-operated control. Hyperprolactinaemia did not affect the formation of ethanol-induced gastric ulcers but showed a 40% reduction in the development of indometacin-induced gastric ulcers. It also produced a 20% increase in the ulcer index in acetic acid-induced chronic gastric ulcers and a 30% increase in ulcer area in mercaptamine-induced duodenal ulcers. Our results showed that hyperprolactinaemia induced gastric acid secretion and thereby aggravated gastric and duodenal ulcers in rats. Hyperprolactinaemia did not affect gastric cytoprotection.
Asad
M
M
Department of Pharmacology, Jawaharlal Institute of Post-Graduate Medical Education & Research, Pondicherry, India.
Shewade
D G
DG
Koumaravelou
K
K
Abraham
B K
BK
Balasinor
N
N
Ramaswamy
S
S
D019342:Acetic Acid / Q000633:toxicity; D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D003543:Cysteamine / Q000633:toxicity; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000209:etiology*; D005744:Gastric Acid / Q000378:metabolism; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications* / Q000209:etiology; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000601:surgery*; D008297:Male; D010902:Pituitary Gland / Q000637:transplantation*; D011388:Prolactin / Q000097:blood; D011708:Pylorus / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology*; D014184:Transplantation, Homologous / Q000009:adverse effects
D003543:Cysteamine; D011388:Prolactin; D019342:Acetic Acid; D007213:Indomethacin