Plasmid-mediated TEM-3 extended-spectrum beta-lactamase production in Salmonella typhimurium in Casablanca.
Isolates of extended-spectrum beta-lactamase (ESBL)-producing Salmonella typhimurium were recovered from children admitted to the IbnRochd University Hospital of Casablanca in 1994. These isolates produced TEM-3 as shown by PCR, isoelectric focusing and sequencing. Production of TEM-3 and resistance to gentamicin were encoded by a 10 kb plasmid that could be transferred by conjugation and transformation. This report extends the list of ESBLs produced by S. typhimurium and stresses the need for continuous surveillance of non-typhoidal Salmonella to adapt antibiotic treatment and preventive measures.
AitMhand
Rajaa
R
IbnRochd University Hospital, Casablanca, Morocco.
Soukri
Abdelaziz
A
Moustaoui
Najat
N
Amarouch
Hamid
H
ElMdaghri
Naima
N
Sirot
Danielle
D
Benbachir
Mohamed
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D009018:Morocco; D010957:Plasmids / Q000235:genetics* / Q000302:isolation & purification; D012486:Salmonella typhimurium / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D005839:Gentamicins; C055184:beta-lactamase TEM-3; D001618:beta-Lactamases