Cytotoxic mono-tetrahydrofuran ring acetogenins from leaves of Annona montana.
Further studies on leaves of Annona montana led to isolation of one iso-acetogenin, montanacin G, three pairs of acetogenins, montanacin H-J and 34-epi-montanacin H-J, together with four known acetogenins, gigantetrocins A and B, annonacin and cis-annonacin. Montanacin G belongs to the iso-acetogenin group with a terminal 2,4-trans-ketolactone unit. Montanacin H-J and 34-epi-montanacin H-J contain the rare gamma-hydroxy-gamma-methyl-gamma-lactone moiety. The cytotoxic activities of these compounds, together with previously reported acetogenins, montanacins B and C, were examined against Meth-A and LLC tumor cell lines in vitro.
Wang
L Q
LQ
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.
Li
Y
Y
Min
B S
BS
Nakamura
N
N
Qin
G W
GW
Li
C J
CJ
Hattori
M
M
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D029061:Annonaceae; D002455:Cell Division / Q000187:drug effects; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D014197:Trees / Q000737:chemistry; D014407:Tumor Cells, Cultured
D005233:Fatty Alcohols; D005663:Furans; D010936:Plant Extracts; D015107:4-Butyrolactone