title: Some factors influencing transmission of toxoplasma in pregnant rats fed cysts.
abstract: An overall 44% transplacental transmission rate was observed in 221 rats fed cysts of 12 Toxoplasma strains at 15 days of pregnancy, with a range of 0-90% transmission. Considerable variability in the transmission rate was seen among different groups of rats that received similar Toxoplasma inocula; this is attributed to genetically based susceptibility to Toxoplasma among individuals of the outbred Wistar strain of rats. Transplacental transmission was more frequent in Long Evans than in Wistar rats. Significant differences in the rate of transmission were not found between rats that were fed similar Toxoplasma inocula 6-8 days or 15 days after conception. The frequency of transmission was not affected by the strain or dose of Toxoplasma used.
authors.affiliation: Depto de Parasitologia, Facultad de Veterinaria, Montevideo, Uruguay. freyrealvaro@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Freyre
authors.forename: O
authors.initials: O
authors.lastname: Correa
authors.forename: J
authors.initials: J
authors.lastname: Falcón
authors.forename: J
authors.initials: J
authors.lastname: Mendez
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: J M
authors.initials: JM
authors.lastname: Venzal
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000913:Antibodies, Protozoan / Q000032:analysis; D004195:Disease Models, Animal; D005260:Female; D005865:Gestational Age; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D051381:Rats; D020318:Rats, Long-Evans / Q000276:immunology / Q000469:parasitology; D017208:Rats, Wistar / Q000276:immunology / Q000469:parasitology; D012376:Rodent Diseases / Q000151:congenital* / Q000276:immunology / Q000635:transmission*; D013045:Species Specificity; D014122:Toxoplasma / Q000145:classification / Q000276:immunology / Q000502:physiology*; D014124:Toxoplasmosis, Animal / Q000151:congenital* / Q000276:immunology / Q000635:transmission*
chemical_list: D000913:Antibodies, Protozoan