title: Spontaneous chiral separation in noncovalent molecular clusters.
abstract: A new method is introduced to determine the extent to which spontaneous chiral separation occurs in small noncovalently bound clusters. Soft-sampling electrospray ionization was used to transfer noncovalent complexes from solution to the gas phase. Mixing D and L enantiomers with one of the pair isotopically labeled reveals the effect of chirality on cluster stability. The observed cluster distribution is compared to the predicted statistical distribution to determine any preference for homo- or heterochirality. Arginine, for example, forms a stable trimer with no preference for the chirality of the individual amino acids. Serine, however, forms a protonated octamer with a pronounced preference for homochirality. The implications of these results for the structures of the complexes are discussed along with the broader implications for the origins of homochirality in living systems (homochirogenesis).
authors.affiliation: Department of Chemistry and Beckman Institute, California Institute of Technology, Pasadena, California 91125, USA.
authors.forename: R
authors.initials: R
authors.lastname: Hodyss
authors.forename: R R
authors.initials: RR
authors.lastname: Julian
authors.forename: J L
authors.initials: JL
authors.lastname: Beauchamp