Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion.
We have analyzed the organization and sequence of 73 V1R genes encoding putative pheromone receptors to identify regulatory features and characterize the evolutionary history of the V1R family. The 73 V1Rs arose from seven ancestral genes around the time of mouse-rat speciation through large local duplications, and this expansion may contribute to speciation events. Orthologous V1R genes appear to have been lost during primate evolution. Exceptional noncoding homology is observed across four V1R subfamilies at one cluster and thus may be important for locus-specific transcriptional regulation.
Lane
Robert P
RP
Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195,USA. rlane@fhcrc.org
Cutforth
Tyler
T
Axel
Richard
R
Hood
Leroy
L
Trask
Barbara J
BJ
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D002628:Chemoreceptor Cells / Q000502:physiology*; D018076:DNA, Complementary / Q000378:metabolism; D005091:Exons; D015723:Gene Library; D016678:Genome; D015894:Genome, Human; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D051381:Rats; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D019147:Vomeronasal Organ / Q000378:metabolism*
D018076:DNA, Complementary