title: Proposed revised electrophysiological criteria for chronic inflammatory demyelinating polyradiculoneuropathy.
abstract: Electrophysiological criteria for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) were proposed by an Ad Hoc Subcommittee of the American Academy of Neurology (AAN) in 1991. Only 60% of CIDP patients fulfilled these criteria, which therefore appear poorly sensitive. We therefore sought to revise the electrophysiological criteria. We selected 40 CIDP patients and compared them with 35 patients with axonal polyneuropathy, 116 patients with Charcot-Marie-Tooth type 1A (CMT1A) disease, and 66 patients with immunoglobulin M (IgM) monoclonal gammopathy. The proposed electrophysiological criteria identified 90% of the CIDP patients, although 3% of patients with axonal polyneuropathy were falsely identified. For the CIDP patients, sensitivity and specificity were 90% and 97%, respectively. Of the patients with IgM monoclonal gammaglobulin of undetermined significance (MGUS) and CMT1A, 100% fulfilled these new criteria, whereas 90% and 97%, respectively, fulfilled the AAN criteria. These results suggest that the AAN criteria are more appropriate for IgM MGUS and CMT1A patients than for CIDP patients. We therefore propose new electrophysiological criteria for CIDP that appear to have better sensitivity.
authors.affiliation: Neurophysiology Service, Salpêtrière Hospital, 47 Boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Nicolas
authors.forename: Thierry
authors.initials: T
authors.lastname: Maisonobe
authors.forename: Nadine
authors.initials: N
authors.lastname: Le Forestier
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Léger
authors.forename: Pierre
authors.initials: P
authors.lastname: Bouche
mesh_terms: D000328:Adult; D000368:Aged; D002607:Charcot-Marie-Tooth Disease / Q000175:diagnosis; D003937:Diagnosis, Differential; D004568:Electrodiagnosis / Q000379:methods*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000175:diagnosis; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis*; D012680:Sensitivity and Specificity