title: Papillary serous carcinoma of the uterus: increased risk of subsequent or concurrent development of breast carcinoma.
abstract: OBJECTIVE
  Some women with endometrial cancer may be at increased risk for developing breast cancer. The histologic type of endometrial cancer associated with synchronous or subsequent breast cancer has not been clearly established. Our purpose was to determine if a certain histologic type of endometrial cancer was associated with an increased risk of synchronous or subsequent breast cancer.
  
  
  METHODS
  The University of Iowa Hospitals and Clinics tumor registry was queried to ascertain all patients with the diagnosis of uterine cancer from January 1, 1983, to December 31, 1994. Statistics were performed utilizing SPSS for Windows version 9.0 (SPSS Inc., Chicago, IL), including Student's t tests and chi(2) tests.
  
  
  RESULTS
  Five hundred ninety-two patients had endometrial adenocarcinoma during the study period. Five hundred thirty-six women had endometrioid adenocarcinoma, 23 women had papillary serous carcinoma (UPSC), 21 women had adenosquamous carcinoma, 10 women had clear-cell carcinoma, and 1 woman each had mucinous or squamous carcinoma. Twelve patients had previously been diagnosed with breast carcinomas. Twenty-five patients were diagnosed with breast cancer either concurrently or subsequent to their diagnosis of endometrial cancer. Synchronous or subsequent breast cancers developed in 3.2% of patients with endometrioid carcinoma and in 25% of patients with UPSC (P < 0.001).
  
  
  CONCLUSIONS
  Patients with UPSC have an increased risk of development of breast cancer as compared to patients with endometrioid adenocarcinoma of the uterus.
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Geisler
authors.forename: J I
authors.initials: JI
authors.lastname: Sorosky
authors.forename: H L
authors.initials: HL
authors.lastname: Duong
authors.forename: T E
authors.initials: TE
authors.lastname: Buekers
authors.forename: M J
authors.initials: MJ
authors.lastname: Geisler
authors.forename: A K
authors.initials: AK
authors.lastname: Sood
authors.forename: B
authors.initials: B
authors.lastname: Anderson
authors.forename: R E
authors.initials: RE
authors.lastname: Buller
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D018283:Cystadenocarcinoma, Papillary / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000473:pathology*