Antifungal sordarins. Synthesis and structure-activity relationships of 3',4'-fused dioxolane and dioxane derivatives.
A number of novel 3',4'-fused dioxolane and dioxane sordarin derivatives were synthesised for structure-activity relationship studies. Many of these derivatives exhibit high activity against Candida spp. and Cryptococcus neoformans.
Bueno
José M
JM
GlaxoSmithKline, Research Department, Parque Tecnológico de Madrid, Severo Ochoa, 2. 28760 Tres Cantos, Madrid, Spain.
Cuevas
Juan C
JC
Fiandor
José M
JM
García-Ochoa
Silvestre
S
Gómez de las Heras
Federico
F
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D004146:Dioxanes / Q000737:chemistry*; D004148:Dioxolanes / Q000737:chemistry*; D007192:Indenes; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D004146:Dioxanes; D004148:Dioxolanes; D007192:Indenes; C003329:sordarin; C010962:formal glycol