title: Biotransformation of terpenes from Stemodia maritima by Aspergillus niger ATCC 9142.
abstract: Incubation of stemodin (1) in cultures of Aspergillus niger ATCC 9142 resulted in the production of 2alpha,3beta,13-trihydroxystemodane (2), 2alpha,7beta,13-trihydroxystemodane (3) and 2alpha,13,16beta-trihydroxystemodane (4), while stemodinone (5) afforded 13,18-dihydroxystemodan-2-one (6) and 13,16beta-dihydroxystemodan-2-one (7). Four novel metabolites were obtained from the bioconversion of stemarin (8) by the fungus, namely 18-hydroxystemaran-19-oic acid (9), 7beta,18-dihydroxystemaran-19-oic acid (10), 7alpha,18,19-trihydroxystemarane (11) and 1beta-hydroxystemaran-19-oic acid (12). 19-N,N-Dimethylcarbamoxy-13-hydroxystemarane (13) was also transformed to afford 19-N,N-dimethylcarbamoxy-13,17xi,18-trihydroxystemarane (14).
authors.affiliation: Department of Chemistry, University of the West Indies, Mona, 7, Kingston, Jamaica.
authors.forename: Avril R M
authors.initials: AR
authors.lastname: Chen
authors.forename: Paul B
authors.initials: PB
authors.lastname: Reese
mesh_terms: D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D004224:Diterpenes / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C450164:13,18-dihydroxystemodan-2-one; C450162:2,3,13-trihydroxystemodane; D004224:Diterpenes; C074341:stemodin; C450163:stemodinone