Rapidly progressive glomerulonephritis due to rifampicin therapy.
A 60-year-old man was treated with rifampicin, isoniazid, ethambutol and pyrazinamide for pulmonary tuberculosis. Acute renal failure developed 1 month after re-administration of rifampicin following 1 month's interruption of treatment. A renal biopsy showed crescentic lesions characteristic of rapidly progressive glomerulonephritis. This is, to our knowledge, the fourth case of rapidly progressive crescentic glomerulonephritis associated with rifampicin treatment, which responded to methylprednisolone pulse therapy followed by oral steroid therapy.
Yoshioka
Keiji
K
First Department of Internal Medicine, Matsushita Memorial Hospital, Moriguchi, Osaka, Japan.
Satake
Norio
N
Kasamatsu
Yoshihiro
Y
Nakamura
Yoshio
Y
Shikata
Nobuaki
N
D000904:Antibiotics, Antitubercular / Q000009:adverse effects; D018450:Disease Progression; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000009:adverse effects*
D000904:Antibiotics, Antitubercular; D012293:Rifampin