title: Chlamydial genovar distribution after community wide antibiotic treatment.
abstract: Major outer membrane protein sequences, determined from Chlamydia-positive eye swab samples collected in 2 Egyptian villages, were used to analyze the epidemiology of trachoma in an endemic setting. Samples were collected during the 1999 Azithromycin in Control of Trachoma trial, in which residents of villages were mass treated with either oral azithromycin or topical tetracycline and were followed up for nearly 2 years. Three genovar families (A, Ba, and C) and 12 genovars were detected, with 2 genovars (A1 and Ba1) comprising almost 75% of the samples. The presence of >1 genovar within households was common, with > or =24% of households having >1 genovar. Evidence consistent with reinfection and persistence as mechanisms of communitywide continued presence of trachoma was provided by data for individuals infected with rare genovars.
authors.affiliation: Division of Infectious Diseases, University of California, Berkeley, CA 94720-7360, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Bain
authors.forename: T
authors.initials: T
authors.lastname: Lietman
authors.forename: S
authors.initials: S
authors.lastname: Rasmussen
authors.forename: S
authors.initials: S
authors.lastname: Kalman
authors.forename: J
authors.initials: J
authors.lastname: Fan
authors.forename: C
authors.initials: C
authors.lastname: Lammel
authors.forename: J Z
authors.initials: JZ
authors.lastname: Zhang
authors.forename: C R
authors.initials: CR
authors.lastname: Dawson
authors.forename: J
authors.initials: J
authors.lastname: Schachter
authors.forename: R S
authors.initials: RS
authors.lastname: Stephens
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D003234:Conjunctivitis, Bacterial / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis / Q000302:isolation & purification; D006801:Humans; D017720:Molecular Epidemiology; D016133:Polymerase Chain Reaction; D012424:Rural Population; D017422:Sequence Analysis, DNA; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; C078167:OMPA outer membrane proteins; D017963:Azithromycin; D013752:Tetracycline