title: Synthesis and anti-microbial activities of some pyridinium salts with alkoxymethyl hydrophobic group.
abstract: A novel class of functionalized cationic surfactant has been obtained. The work-up procedure of synthesis is very simple, the yield is high and the pyridinium salts with alkoxymethyl hydrophobic group are easily purified. All the salts examined showed anti-microbial activities. Some of them exhibited strong activity and wide anti-bacterial spectra similar to the activity of benzalkonium chloride. The relationship between chemical structure and anti-microbial activity was analysed by the QSAR method.
authors.affiliation: Poznań University of Technology, Skłodowskiej-Curie 2, 60-965 Poznań, Poland. juliusz.pernak@put.poznan.pl
authors.forename: J
authors.initials: J
authors.lastname: Pernak
authors.forename: J
authors.initials: J
authors.lastname: Kalewska
authors.forename: H
authors.initials: H
authors.lastname: Ksycińska
authors.forename: J
authors.initials: J
authors.lastname: Cybulski
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011726:Pyridinium Compounds