Total synthesis of natural product DNA cross-linking agents.
A variety of naturally occurring compounds interact with duplex DNA by the formation of covalent cross-links. This review describes recent progress on the total synthesis of four natural product families, including the mitomycins, the structurally and functionally related agent FR-900482, the bis-pyrrole isochrysohermidine and the azinomycins.
Coleman
R S
RS
Department of Chemistry, Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA. coleman@chemistry.ohio-state.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D001685:Biological Factors / Q000138:chemical synthesis* / Q000627:therapeutic use; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000627:therapeutic use; D004247:DNA / Q000737:chemistry*; D006801:Humans; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry*
D000970:Antineoplastic Agents; D001685:Biological Factors; D003432:Cross-Linking Reagents; D009692:Nucleic Acid Heteroduplexes; D004247:DNA