DNA cleavage by aromatic amines.
A series of aryl amines was found to induce cleavage of DNA. Subsequent refinement led to an efficient family of dimeric derivatives capable of cleavage at low concentration. Initial investigations suggest this is an unprecedented mode of DNA cleavage, which may be ultimately applied to the development of sequence-specific agents.
Warner
Philip M
PM
Department of Chemistry, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA. pwarner@lynx.neu.edu
Qi
Jiwei
J
Meng
Bin
B
Li
Gang
G
Xie
Longfei
L
El-Shafey
Ahmed
A
Jones
Graham B
GB
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001435:Bacteriophages / Q000235:genetics; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D004249:DNA Damage; D019281:Dimerization; D006868:Hydrolysis / Q000187:drug effects; D013329:Structure-Activity Relationship
D000588:Amines; D000970:Antineoplastic Agents; D004247:DNA