title: Computer-assisted image analysis of the rat postosteonecrotic remodeled femoral head.
abstract: Osteonecrosis of rat femoral heads was induced by stripping the periosteum of the neck and cutting the ligamentum teres. The epiphyseal marrow and bone were necrotic on the 5th postoperative day. Specimens obtained 18 and 36 days postoperatively showed fibrous and hematopoietic-fatty tissue in the intertrabecular spaces, osteoclastic bone resorption, osteogenesis, and degeneration of the joint cartilage. Morphometrically, the means of the height-to-length ratios of the control, 6-day, 18-day, and 36-day femoral heads were 0.26, 0.28, 0.48, and 0.29, respectively. The shape factor of the femoral heads of the control rats was higher than 0.81 in 80% of the cases, while those of rats killed on the 6th, 18th, and 36th postoperative day were higher than 0.81 in 65, 60, and 50% of cases, respectively. Statistically, the means of the height-to-length ratios and the values of the shape factors of the femoral heads of the rats killed 18 days postoperatively differed significantly from those of the other three groups of rats. The quantitatively gauged data of the remodeled epiphyses negate the authors' subjective impression concerning early flattening of the femoral heads after surgically produced osteonecrosis.
authors.affiliation: Department of Pathology, HaCarmel Hospital, Haifa, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Sabo
authors.forename: B
authors.initials: B
authors.lastname: Peskin
authors.forename: I
authors.initials: I
authors.lastname: Misselevich
authors.forename: C
authors.initials: C
authors.lastname: Zinman
authors.forename: D
authors.initials: D
authors.lastname: Levin
authors.forename: D
authors.initials: D
authors.lastname: Norman
authors.forename: D N
authors.initials: DN
authors.lastname: Reis
authors.forename: J H
authors.initials: JH
authors.lastname: Boss
mesh_terms: D000818:Animals; D016723:Bone Remodeling; D004195:Disease Models, Animal; D005270:Femur Head / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D007091:Image Processing, Computer-Assisted; D008297:Male; D010020:Osteonecrosis / Q000473:pathology* / Q000601:surgery; D051381:Rats; D017207:Rats, Sprague-Dawley