beta-Cell death during progression to diabetes.
The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta-cells. Apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.
Mathis
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D
Section on Immunology and Immunogenetics, Joslin Diabetes Centre, One Joslin Place, Boston, Massachusetts 02215, USA.
Vence
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L
Benoist
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C
D000818:Animals; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D016923:Cell Death; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007515:Islets of Langerhans / Q000276:immunology / Q000473:pathology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens; D018836:Inflammation Mediators