title: [Parenteral disodium-clodronate in patients with rheumatoid arthritis. A two-month open clinical study].
abstract: BACKGROUND
  The aim of the study was to evaluate the effect on articular pain of 100 mg of disodium-clodronate administered daily by intramuscular injection in patients affected by rheumatoid arthritis.
  
  
  METHODS
  We studied 24 patients with established rheumatoid arthritis, in the II and III stage according to Steinbrocker. Visual analogue pain scale, physician global assessment activity and patient global assessment activity were recorded at baseline, after 30 days and after 60 days of treatment.
  
  
  RESULTS
  VAS significant improvement after 30 days was found. The physician and patient global assessment activity were improved after 60 days of treatment.
  
  
  CONCLUSIONS
  Disodium-clodronate given by intramuscular injection at the dose of 100 mg/die in rheumatoid patients vas effective in relieving joint pain during a two-month observation.
authors.affiliation: Istituto E. Bruzzone Centro Reumatologico, Cattedra di Reumatologia, Dipartimento di Scienze Endocrinologiche e Metaboliche, ASL n. 3, Università degli Studi, Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rovetta
authors.forename: P
authors.initials: P
authors.lastname: Monteforte
authors.forename: L
authors.initials: L
authors.lastname: Molfetta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004002:Clodronic Acid / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
chemical_list: D018712:Analgesics, Non-Narcotic; D004002:Clodronic Acid