Relative roles of endothelial cell damage and platelet activation in primary Raynaud's phenomenon (RP) and RP secondary to systemic sclerosis.
OBJECTIVE
To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc.


METHODS
Endothelial derived ET-1, t-PA, PAI-1, and platelet derived beta-TG, PDGF, TGF-beta were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls.


RESULTS
A significative increase of ET-1, t-PA, PAI-1, TGF-beta, and beta-TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and beta-TG levels were observed in patients with primary RP vs controls.


CONCLUSIONS
These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc.
Silveri
F
F
Department of Rheumatology, Ancona University, Ospedale A. Murri, Jesi, Italy. fesilve@tin.it
De Angelis
R
R
Poggi
A
A
Muti
S
S
Bonapace
G
G
Argentati
F
F
Cervini
C
C
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood; D004727:Endothelium / Q000166:cytology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D015539:Platelet Activation; D010982:Platelet-Derived Growth Factor / Q000032:analysis; D011928:Raynaud Disease / Q000503:physiopathology*; D012595:Scleroderma, Systemic / Q000150:complications*; D010959:Tissue Plasminogen Activator / Q000097:blood; D016212:Transforming Growth Factor beta / Q000097:blood; D001620:beta-Thromboglobulin / Q000032:analysis
D015415:Biomarkers; D019332:Endothelin-1; D017395:Plasminogen Activator Inhibitor 1; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D001620:beta-Thromboglobulin; D010959:Tissue Plasminogen Activator