Blood pressure variability is increased in genetic hypertension and L-NAME -induced hypertension.
OBJECTIVE
To examine whether the blood pressure variability (BPV) is increased in spontaneously hypertensive rats (SHR) and L-NAME-induced hypertensive rats (NHR).


METHODS
BPV was recorded with continuous hemodynamic monitoring in conscious un restrained rats. Time course of L-NAME-induced hypertension was measured by the tail-cuff method. Plasma NO concentration was determined by the method of nitric acid reductase.


RESULTS
In both SHR and NHR, systolic and diastolic BPV were significantly increased when compared with their respective controls. In S HR, in crease in diastolic BPV was predominant, whereas in NHR, increase in systolic BP V was predominant. Moreover, increase in systolic BPV in NHR (102 %) was obviously higher than that in SHR (28 %). Chronic administration of L-NAME 1 g/L in drink ing water caused a progressive increase in arterial blood pressure in rats. All rats were hypertensive at 4 weeks after treatment. Plasma NO level was decreased in NHR.


CONCLUSIONS
Increased BPV is a general phenomenon in hypertension. NO is involved in the regulation of BPV.
Miao
C Y
CY
Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China.
Shen
F M
FM
Su
D F
DF
D000818:Animals; D001794:Blood Pressure; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000097:blood; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017207:Rats, Sprague-Dawley
D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester