Neuralized: regulating notch by putting away delta.
Neuralized acts in a subset of Notch-dependent cell fate decisions including lateral inhibition in Drosophila neurogenesis. Three recent papers reveal that Neuralized acts as a ubiquitin ligase and triggers endocytosis of the ligand Delta.
Krämer
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Center for Basic Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008025:Ligases; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases
D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D015534:Trans-Activators; C064045:delta protein; D044767:Ubiquitin-Protein Ligases; C071006:neur protein, Drosophila; D008025:Ligases