The genetics and epigenetics of orofacial clefts.
Orofacial clefts (cleft lip, cleft palate) are among the most common of all major birth defects, but very little is known about their causation. Genetic factors are thought to play a major role, and there has been considerable recent effort to map and identify genes that constitute risk factors for clefts. This review will put into perspective the frequently-conflicting results of these studies.
Spritz
R A
RA
Department of Pediatrics and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, USA.
D002971:Cleft Lip / Q000235:genetics* / Q000503:physiopathology; D002972:Cleft Palate / Q000235:genetics* / Q000503:physiopathology; D005492:Folic Acid / Q000502:physiology; D008040:Genetic Linkage; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D051957:MSX1 Transcription Factor; D009154:Mutation; D013577:Syndrome; D020825:T-Box Domain Proteins / Q000235:genetics; D014157:Transcription Factors
D018398:Homeodomain Proteins; D051957:MSX1 Transcription Factor; D020825:T-Box Domain Proteins; C416943:TBX22 protein, human; D014157:Transcription Factors; D005492:Folic Acid