Natural resistance of 129/SvJ mice to Strongyloides venezuelensis infection.
The susceptibility of 129/SvJ mice to infection with Strongyloides venezuelensis was compared with that of C57BL/6 mice. After a primary infection, daily egg output in faeces (EPG) from 129/SvJ mice was lower and terminated earlier than that from C57BL/6 mice. Adult worm recovery from the small intestine of 129/SvJ mice on day 7 was also lower than that of C57BL/6 mice. When the numbers of larvae recovered from the lungs were examined on days 2, 3 and 4 after a primary infection, they were comparable between the two strains. On the other hand, when an equal number of larvae recovered from the lungs of each strain on day 3 were implanted orally into homologous strain mice, the magnitude of EPG and the number of adult worms in the small intestine on day 5 after implantation were significantly lower in 129/SvJ than in C57BL/6 mice. The number of mucosal mast cells in the jejunum was not significantly different between 129/SvJ and C57BL/6 naive mice. Total chondroitin sulphate concentration in the gut washings obtained from naive mice was significantly higher in 129/SvJ (11.34 +/- 9.48) than in C57BL/6 mice (1.09 +/- 0.77, P < 0.05). These results indicate that the natural resistance of 129SvJ mice to S. venezuelensis infection is expressed at the intestine, probably due to higher concentration of chondroitin sulphate, which prevents establishment of S. venezuelensis.
Nakamura-Uchiyama
F
F
Department of Parasitology, Miyazaki Medical College, Kiyotake, Miyazaki, Japan.
Nagao
T
T
Obara
A
A
Ishiwata
K
K
Nawa
Y
Y
D000818:Animals; D002809:Chondroitin Sulfates / Q000032:analysis; D004195:Disease Models, Animal; D007113:Immunity, Innate; D007421:Intestine, Small / Q000737:chemistry / Q000276:immunology / Q000469:parasitology; D008297:Male; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D010270:Parasite Egg Count; D051381:Rats; D017208:Rats, Wistar; D013321:Strongyloides / Q000254:growth & development / Q000276:immunology*; D013322:Strongyloidiasis / Q000276:immunology* / Q000469:parasitology
D002809:Chondroitin Sulfates