title: Serum beta-carotene in anorexia nervosa patients: a case-control study.
abstract: OBJECTIVE
  To study the prevalence of hypercarotenemia in a large cohort of patients with anorexia nervosa (AN), to compare serum beta-carotene (betaC) values among restricting and purging AN subjects, and to investigate whether hypercarotenemia is related to an increase in low-density lipoprotein (LDL) cholesterol.
  
  
  METHODS
  Retrospective case-control study including 101 female patients and 95 age-matched normal controls in whom fasting serum betaC and lipid profiles were determined.
  
  
  RESULTS
  The prevalence of hypercarotenemia (>200 microg/dl) in the AN population was 62%. Mean serum betaC level was significantly higher in AN patients than in controls (237 +/- 103 vs. 160 +/- 45 microg/dl, p <.0001). Among AN patients, the level was higher in restricters than in purgers (271 +/- 110 vs. 186 +/- 78 microg/dl, p <.005). Fasting serum total and LDL cholesterol levels were also significantly higher in patients with AN than in controls, but no correlation was found between serum betaC and LDL cholesterol values.
  
  
  CONCLUSIONS
  Hypercarotenemia is a common finding in AN patients, especially in the restricter subgroup. The high prevalence of elevated serum betaC in AN patients supports its diagnostic value in atypical forms of eating disorders.
authors.affiliation: Saint-Luc University Hospital, Catholic University of Louvain in Brussels, Brussels, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Boland
authors.forename: C
authors.initials: C
authors.lastname: Beguin
authors.forename: F
authors.initials: F
authors.lastname: Zech
authors.forename: J P
authors.initials: JP
authors.lastname: Desager
authors.forename: M
authors.initials: M
authors.lastname: Lambert
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood*; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology* / Q000503:physiopathology; D015995:Prevalence; D012189:Retrospective Studies; D019207:beta Carotene / Q000097:blood*
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D019207:beta Carotene