Polymorphic proteins of Chlamydia spp.--autotransporters beyond the Proteobacteria.
Gram-negative bacteria secrete a variety of proteins to the cell surface and beyond, a process with many inherent difficulties. An exceptionally widespread answer to these problems is the type V (or autotransporter) secretion pathway. By exploiting the data made available by bacterial genome sequencing, we have discovered that the previously described polymorphic proteins of Chlamydia spp. resemble members of the autotransporter family, and we suggest that they follow the same secretion pathway.
Henderson
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Division of Immunity and Infection, The Medical School, University of Birmingham, Edgbaston, B15 2TT., Birmingham, UK. i.r.henderson@bham.ac.uk
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D000595:Amino Acid Sequence; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002689:Chlamydia / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016680:Genome, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics; D020560:Proteobacteria / Q000235:genetics / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins