A RAVE about opioid withdrawal.
Control of trafficking of g protein-linked receptors is thought to be an important regulatory mechanism for receptor signaling. Finn and Whistler test the hypothesis that agonist-induced trafficking of opioid receptors regulates the development of tolerance and dependence. The results show that measures of tolerance and withdrawal to morphine are decreased under conditions where receptors are trafficked through the endocytic/recycling pathway.
Alvarez
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Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Arttamangkul
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S
Williams
J T
JT
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D004361:Drug Tolerance / Q000502:physiology; D006801:Humans; D009020:Morphine / Q000494:pharmacology; D009294:Narcotics / Q000493:pharmacokinetics*; D011957:Receptors, Opioid / Q000819:agonists / Q000502:physiology*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D000701:Analgesics, Opioid; D009294:Narcotics; D011957:Receptors, Opioid; D009020:Morphine