[Effects of aluminum and deferoxamine on concentration of essential elements in animals experimentally intoxicated with aluminum].
To assess the effect of aluminium intoxication in tissues of experimental animals on Ca, Mg, Zn, Cu, and Fe concentration, aluminium nitrate was administered intraperitoneally to mice at a daily dose of 0.27 mMol/kg for 5 weeks. Concentration of Al, Ca, Mg, Zn, Cu, and Fe were analyzed by atomic absorption spectrometry. The Al content in liver and tibia was significantly higher in treated mice in comparison with control group. In Al loaded tissues the significant increase of all tested essential elements was found. To evaluate the results of DFO treatment on essential elements, mice received 6 times intraperitoneally 3.5 mMol/kg of DFO. This treatment had generally no effect on reduction of Al concentration in tibia and liver, as well as on changes in essential elements concentration.
Fiejka
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Zakład Badania Surowic i Szczepionek PZH w Warszawie.
Długaszek
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M
Graczyk
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A
Słowikowska
M
M
Górska
P
P
D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D003676:Deferoxamine / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007501:Iron / Q000378:metabolism; D008099:Liver / Q000737:chemistry; D008274:Magnesium / Q000378:metabolism; D008670:Metals / Q000032:analysis / Q000378:metabolism*; D051379:Mice; D009566:Nitrates / Q000633:toxicity*; D013977:Tibia / Q000737:chemistry; D015032:Zinc / Q000378:metabolism
D017607:Aluminum Compounds; D008670:Metals; D009566:Nitrates; D003300:Copper; D007501:Iron; C050609:aluminum nitrate; D008274:Magnesium; D003676:Deferoxamine; D015032:Zinc; D002118:Calcium