Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis.
Burkholderia cepacia is a group of organisms that comprises seven genotypically distinct species (B cepacia genomovars I-VII), which are collectively known as the B cepacia complex. Preoperative infection with B cepacia is associated with a poor prognosis in lung transplant recipients with cystic fibrosis. Many centres do not, therefore, offer transplants to these individuals. Our aim was to ascertain whether or not post-transplant mortality is affected by pretransplant genomovar status. We studied archived isolates with PCR-based methods, and recorded excessive mortality in patients infected with B cepacia genomovar III, but not in those infected with other genomovars.
De Soyza
A
A
McDowell
A
A
Archer
L
L
Dark
J H
JH
Elborn
S J
SJ
Mahenthiralingam
E
E
Gould
K
K
Corris
P A
PA
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019121:Burkholderia Infections / Q000150:complications* / Q000188:drug therapy; D016956:Burkholderia cepacia / Q000235:genetics*; D002097:C-Reactive Protein / Q000378:metabolism; D003550:Cystic Fibrosis / Q000150:complications* / Q000401:mortality / Q000601:surgery; D016208:Databases, Factual; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D016040:Lung Transplantation; D011379:Prognosis; D015996:Survival Rate
D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein