Cytotoxic polyacetylenic alcohols from the marine sponge Petrosia species.
New polyacetylenic alcohols (1-5) have been isolated as cytotoxic principles from the marine sponge Petrosia sp. The compounds were particularly cytotoxic against a human melanoma cell line (SK-MEL-2). The gross structures were established on the basis of NMR and MS data, and the absolute configuration was determined by the modified Mosher's method.
Lim
Y J
YJ
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
Lee
C O
CO
Hong
J
J
Kim
D K
DK
Im
K S
KS
Jung
J H
JH
D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000438:Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016543:Central Nervous System Neoplasms; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms; D004261:DNA Replication / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053279:Polyynes; D011161:Porifera / Q000737:chemistry*; D013539:Simian virus 40 / Q000187:drug effects; D012878:Skin Neoplasms; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000438:Alcohols; D000970:Antineoplastic Agents; D011108:Polymers; D053279:Polyynes; D000114:Acetylene