Small changes in expression affect predisposition to tumorigenesis.
We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.
Yan
Hai
H
The Howard Hughes Medical Institute, The Oncology Center, and The Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.
Dobbie
Zuzana
Z
Gruber
Stephen B
SB
Markowitz
Sanford
S
Romans
Kathy
K
Giardiello
Francis M
FM
Kinzler
Kenneth W
KW
Vogelstein
Bert
B
D000236:Adenoma / Q000235:genetics*; D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000483:Alleles; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005786:Gene Expression Regulation; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D006801:Humans; D019656:Loss of Heterozygosity; D016133:Polymerase Chain Reaction; D013698:Templates, Genetic
D018076:DNA, Complementary; D004273:DNA, Neoplasm