Hippocampal morphometry in depressed patients and control subjects: relations to anxiety symptoms.
BACKGROUND
Although it has been hypothesized that glucocorticoid hypersecretion in depressed patients leads to neuronal atrophy in the hippocampus, magnetic resonance imaging (MRI) -based morphometry studies of the hippocampus to date have produced mixed results.


METHODS
In our MRI study, hippocampal volumes were measured in 25 depressed patients (13 with melancholia and 12 without melancholia) and 15 control subjects.


RESULTS
No significant differences in hippocampus volumes were found between any of the subject groups, although within subjects right hippocampal volumes were found to be significantly larger than left hippocampal volumes. Additionally, right and total (left + right) hippocampal volumes in control and depressed subjects were found to be positively correlated with trait anxiety as measured by the state/trait anxiety inventory.


CONCLUSIONS
Because our subject group is younger than those in studies reporting hippocampal atrophy, we conclude that longitudinal studies will be necessary for investigation of the lifelong course of hippocampal volumetry.
Rusch
B D
BD
Department of Psychology, University of Wisconsin, 1202 West Johnson Street, Madison, WI 53706, USA.
Abercrombie
H C
HC
Oakes
T R
TR
Schaefer
S M
SM
Davidson
R J
RJ
D000328:Adult; D001007:Anxiety / Q000473:pathology*; D001284:Atrophy; D001921:Brain / Q000473:pathology; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000473:pathology* / Q000523:psychology; D003865:Major Depressive Disorder / Q000473:pathology; D004292:Dominance, Cerebral; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged