Withdrawal from nicotine facilitates diazepam binding inhibitor mRNA expression in mouse cerebral cortex.
Changes in diazepam binding inhibitor (DBI) mRNA expression after withdrawal from nicotine were examined. Withdrawal from nicotine Increased DBI mRNA expression in cerebral cortices derived from nicotine-dependent mice and in the neurons continuously exposed to nicotine (0.1 microM). These results indicate that withdrawal from nicotine after its long-term exposure induces steep increase of DBI mRNA expression as reported previously in ethanol- and morphine-dependent animals.
Katsura
M
M
Department of Pharmacology, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Shuto
K
K
Mohri
Y
Y
Tsujimura
A
A
Ohkuma
S
S
D000818:Animals; D001007:Anxiety / Q000503:physiopathology; D002540:Cerebral Cortex / Q000502:physiology*; D026261:Diazepam Binding Inhibitor / Q000378:metabolism*; D015870:Gene Expression / Q000187:drug effects; D051379:Mice; D009538:Nicotine / Q000494:pharmacology; D018722:Nicotinic Agonists / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000235:genetics; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D014029:Tobacco Use Disorder / Q000503:physiopathology*
D026261:Diazepam Binding Inhibitor; D018722:Nicotinic Agonists; D012333:RNA, Messenger; D011978:Receptors, Nicotinic; D009538:Nicotine