title: Core to rind distribution of severe emphysema predicts outcome of lung volume reduction surgery.
abstract: Computed tomography (CT) has shown that emphysema is more extensive in the inner (core) region than in the outer (rind) region of the lung. It has been suggested that the concentration of emphysematous lesions in the outer rind leads to a better outcome following lung volume reduction surgery (LVRS) because these regions tend to be more surgically accessible. The present study used a recently described, computer-based CT scan analysis to quantify severe emphysema (lung inflation > 10.2 ml gas/g tissue), mild/moderate emphysema (lung inflation = 10.2 to 6.0 ml gas/g tissue), and normal lung tissue (lung inflation < 6.0 ml gas/g tissue) present in the core and rind of the lung in 21 LVRS patients. The results show that the quantification of severe emphysema independently predicts change in maximal exercise response and FEV(1). We conclude that a greater extent of severe emphysema in the rind of the upper lung predicts greater benefit from LVRS because it identifies the lesions most accessible to removal by LVRS.
authors.affiliation: University of British Columbia McDonald Research Laboratories, iCAPTURE Centre, St. Paul's Hospital, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakano
authors.forename: H O
authors.initials: HO
authors.lastname: Coxson
authors.forename: S
authors.initials: S
authors.lastname: Bosan
authors.forename: R M
authors.initials: RM
authors.lastname: Rogers
authors.forename: F C
authors.initials: FC
authors.lastname: Sciurba
authors.forename: R J
authors.initials: RJ
authors.lastname: Keenan
authors.forename: K R
authors.initials: KR
authors.lastname: Walley
authors.forename: P D
authors.initials: PD
authors.lastname: Paré
authors.forename: J C
authors.initials: JC
authors.lastname: Hogg
mesh_terms: D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008176:Lung Volume Measurements; D008297:Male; D011013:Pneumonectomy; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome