The dipsogenic effect of the renin-angiotensin system in elasmobranch fish.
This study investigated the control of drinking in elasmobranch fish through manipulation of the homologous renin-angiotensin system (RAS). The smooth muscle relaxant papaverine was found to increase basal drinking levels in the European lesser-spotted dogfish, Scyliorhinus canicula, almost 20-fold. However, this response was significantly reduced with the coadministration of the angiotensin-converting enzyme inhibitor captopril which had no effect when administered alone. Captopril was also found to block a 7-fold increase in drinking rate following administration of homologous angiotensin I in S. canicula. Finally, administration of homologous angiotensin II produced a dose-dependent response in drinking rate in two species of elasmobranchs, S. canicula and the Japanese dogfish, Triakis scyllia. These results demonstrate a central role of the RAS in the control of drinking in elasmobranch fish.
Anderson
W G
WG
School of Biology, Divisionof Environmental and Evolutionary Biology, Gatty Marine Laboratory, University of St. Andrews, St. Andrews, Fife KY16 8LB, Scotland. wga@st-andrews.ac.uk
Takei
Y
Y
Hazon
N
N
D000803:Angiotensin I / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D004284:Dogfish / Q000502:physiology*; D004326:Drinking / Q000187:drug effects; D005260:Female; D005399:Fishes / Q000502:physiology*; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D013894:Thirst / Q000502:physiology*; D014882:Water-Electrolyte Balance
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D000803:Angiotensin I; D002216:Captopril; D010208:Papaverine