Cancer chemoprevention by ginseng in mouse liver and other organs.
Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.
Nishino
H
H
Department of Biochemistry, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tokuda
H
H
Ii
T
T
Takemura
M
M
Kuchide
M
M
Kanazawa
M
M
Mou
X Y
XY
Bu
P
P
Takayasu
J
J
Onozuka
M
M
Masuda
M
M
Satomi
Y
Y
Konoshima
T
T
Kishi
N
N
Baba
M
M
Okada
Y
Y
Okuyama
T
T
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots; D012878:Skin Neoplasms / Q000517:prevention & control*
D016588:Anticarcinogenic Agents; D010936:Plant Extracts