title: Bacterial adherence and immune response in recurrent urinary tract infection.
abstract: OBJECTIVE
  To study the significance of bacterial adherence and humoral immune response in the pathogenesis of recurrent urinary tract infection in adult women.
  
  
  METHODS
  The study population consisted of 30 women with recurrent urinary tract infection (UTI) and 30 healthy women as controls. Bacterial adherence to vaginal epithelial cells was studied. The concentration of serum and urine antibodies against mixed coliform antigen and clinical isolate was determined by enzyme-linked immunosorbant assay (ELISA). The surface hydrophobicity of the organisms was determined. Student's unpaired t-test and Pearson's correlation coefficient test were used in the statistical analysis.
  
  
  RESULTS
  There was an increased adherence of bacteria to vaginal epithelial cells of women with recurrent UTI. The SIgA level in urine was low compared with other antibodies. There was good correlation between the level of free urinary IgG antibody and bacterial adherence.
  
  
  CONCLUSIONS
  This study showed that increased receptivity of vaginal epithelial cells to pathogens and lower local immunity may play an important role in the pathogenesis of recurrent UTI in females.
authors.affiliation: Department of Microbiology, Kasturba Medical College, Mangalore-575001, India. harshapauls@eudoramail.com
authors.forename: E
authors.initials: E
authors.lastname: Suman
authors.forename: K
authors.initials: K
authors.lastname: Gopalkrishna Bhat
authors.forename: B M
authors.initials: BM
authors.lastname: Hegde
mesh_terms: D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D001422:Bacterial Adhesion / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D004847:Epithelial Cells / Q000276:immunology; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007136:Immunoglobulins / Q000097:blood / Q000652:urine; D012008:Recurrence; D014552:Urinary Tract Infections / Q000276:immunology* / Q000503:physiopathology; D014621:Vagina / Q000276:immunology / Q000503:physiopathology
chemical_list: D007136:Immunoglobulins