title: [Complex prevention of thrombotic complications in patients with colorectal cancer during different stages of surgical treatment].
abstract: Time course of parameters characterizing vascular platelet and coagulation hemostasis was studied in 83 patients with colorectal cancer before, during, and for 7 days after surgery. Before the intervention the disorders in regulation of the blood aggregate state present as chronic disseminated intravascular coagulation (DIC) syndrome. The intervention induces the development of subacute DIC syndrome. During the postoperative period disorders in hemostasis system manifest by chronic hypercompensated DIC syndrome. Thrombotic complications during the postoperative period were prevented by fraxiparin 2 h before the intervention and then during 5 days of the postoperative period in a daily dose of 7500 units anti-Ca (about 100 units/kg) and verapamil starting from day 1 after surgery in a dose of 0.2-0.3 mg/kg for 3 days.
authors.forename: O A
authors.initials: OA
authors.lastname: Mal'kov
authors.forename: V T
authors.initials: VT
authors.lastname: Dolgikh
authors.forename: V N
authors.initials: VN
authors.lastname: Lukach
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D001780:Blood Coagulation Tests; D015179:Colorectal Neoplasms / Q000601:surgery*; D004211:Disseminated Intravascular Coagulation / Q000517:prevention & control; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D017762:Nadroparin / Q000008:administration & dosage / Q000627:therapeutic use; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care; D013927:Thrombosis / Q000517:prevention & control*; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D017762:Nadroparin; D006493:Heparin; D014700:Verapamil