title: Effect of topical betaxolol on acute rise of aqueous flare induced by prostaglandin E(2) in pigmented rabbits.
abstract: OBJECTIVE
  To evaluate the effects of topical betaxolol on experimental ocular inflammation.
  
  
  METHODS
  Transcorneal diffusion of 25 microg/mL (7.09 x 10(-2) mmol/L) of prostaglandin E(2) (PGE(2)), placed in a glass cylinder, was employed to induce aqueous flare elevation in pigmented rabbits. Betaxolol was administered topically before PGE(2) application. Aqueous flare was measured with a laser flare cell meter.
  
  
  RESULTS
  Four-, two-, and one-time topical instillations of betaxolol inhibited the PGE(2)-induced aqueous flare elevation by 44% +/- 8%, 32 +/- 7%, and 8 +/- 6%(mean +/- SD), respectively. The inhibition of flare elevation was dependent on the number of betaxolol instillations.
  
  
  CONCLUSIONS
  Topical betaxolol has an inhibitory effect on PGE(2)-induced aqueous flare elevation in rabbit eyes.
authors.affiliation: Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama-shi, Toyama-ken, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yanagisawa
authors.forename: S
authors.initials: S
authors.lastname: Hayasaka
authors.forename: X Y
authors.initials: XY
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Hayasaka
authors.forename: Y
authors.initials: Y
authors.lastname: Nagaki
authors.forename: K
authors.initials: K
authors.lastname: Kitagawa
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D015784:Betaxolol / Q000008:administration & dosage*; D015232:Dinoprostone / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D014606:Uveitis, Anterior / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000319:Adrenergic beta-Antagonists; D015232:Dinoprostone; D015784:Betaxolol