Fully convergent solid phase synthesis of antifreeze glycoprotein analogues.
The convergent solid phase synthesis of C-linked analogues of antifreeze glycoprotein (AFGP) has been achieved. In this approach, three to six carbohydrate residues are simultaneously coupled to a resin-bound polypeptide. Glycopeptides ranging from 1.6 to 3.0 kDa are easily prepared in 26-44% yield demonstrating the utility of this approach.
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Department of Chemistry, State University of New York at Binghamton, Binghamton, New York 13902, USA.
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D021301:Antifreeze Proteins / Q000138:chemical synthesis*; D004187:Disaccharides / Q000737:chemistry; D006031:Glycosylation; D008970:Molecular Weight; D012117:Resins, Synthetic / Q000737:chemistry
D021301:Antifreeze Proteins; D004187:Disaccharides; D012117:Resins, Synthetic