title: Anaphylactic or anaphylactoid reactions in patients undergoing cardiac surgery.
abstract: OBJECTIVE
  To examine the clinical features, treatment, and outcome of anaphylactic and anaphylactoid reactions during cardiac surgery.
  
  
  METHODS
  Retrospective descriptive study.
  
  
  METHODS
  A specialized referral anesthetic allergy clinic at a university teaching hospital.
  
  
  METHODS
  Twenty-three cardiac surgical patients referred after reactions resembling anaphylaxis.
  
  
  METHODS
  None.
  
  
  RESULTS
  The database of the anesthetic allergy clinic was examined, and the data for patients who developed anaphylactic or anaphylactoid reactions were collated and summarized. Twenty-three cardiac surgical patients who experienced signs of anaphylactic or anaphylactoid reactions during anesthesia and surgery from 8 cardiac surgical centers in a major city were referred to the clinic. Cephalosporin antibiotics (30%) and gelatin solutions (Hemaccel) (26%) were the most common (56%) causes of the reactions. Most reactions occurred before the start of cardiopulmonary bypass. Although metaraminol was the first vasopressor used in 18 of 23 patients, it was not effective in 14 patients. Response to epinephrine was immediate and effective in 88% of cases. Rapid placement onto cardiopulmonary bypass facilitated a good outcome and permitted all but one operation to proceed as planned. No intraoperative or postoperative deaths were recorded.
  
  
  CONCLUSIONS
  Of the anaphylactic and anaphylactoid reactions, 60% occurred before cardiopulmonary bypass, and these were caused by antibiotics and gelatin solution. The results from this limited database showed that cardiac surgery proceeded without complications after cardiovascular collapse caused by anaphylactic or anaphylactoid reactions. Rapid institution of cardiopulmonary bypass may be life-saving and should be considered.
authors.affiliation: Department of Anaesthesia and Pain Management, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
authors.forename: S A
authors.initials: SA
authors.lastname: Ford
authors.forename: P C
authors.initials: PC
authors.lastname: Kam
authors.forename: B A
authors.initials: BA
authors.lastname: Baldo
authors.forename: M M
authors.initials: MM
authors.lastname: Fisher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D006348:Cardiac Surgical Procedures; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008680:Metaraminol / Q000627:therapeutic use; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects; D010949:Plasma; D017713:Platelet Transfusion / Q000009:adverse effects; D011479:Protamines / Q000009:adverse effects; D012151:Resuscitation; D012189:Retrospective Studies; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D009466:Neuromuscular Blocking Agents; D011479:Protamines; D014662:Vasoconstrictor Agents; D008680:Metaraminol; D004837:Epinephrine