title: Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells.
abstract: Bioassay-guided fractionation of the H(2)O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compounds 1 - 3 are 1.0, 47.0, 50.0 microg/ml, respectively. Silymarin as a positive control showed the EC(50) value with 5.0 microg/ml.
authors.affiliation: MRRC and College of Pharmacy, Wonkwang University, Iksan, Korea.
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: J Y
authors.initials: JY
authors.lastname: Jun
authors.forename: E K
authors.initials: EK
authors.lastname: Song
authors.forename: K H
authors.initials: KH
authors.lastname: Kang
authors.forename: H Y
authors.initials: HY
authors.lastname: Baek
authors.forename: Y S
authors.initials: YS
authors.lastname: Ko
authors.forename: Y C
authors.initials: YC
authors.lastname: Kim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D005363:Ficusin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020011:Protective Agents; D029907:Psoralea / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D012838:Silymarin / Q000494:pharmacology; D013619:Tacrine; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006575:Heterocyclic Compounds, 3-Ring; D010636:Phenols; D020011:Protective Agents; D012838:Silymarin; C459213:bakuchicin; D013619:Tacrine; D005363:Ficusin; C012765:bakuchiol