title: Severe intoxication from xylazine inhalation.
abstract: We present the first documented case of overdose from xylazine inhalation. The patient developed findings consistent with alpha 2 adrenergic agonist toxicity, eg coma, miosis, apnea, bradycardia, hypothermia, and dry mouth 2 hours after exposure. Standard dose naloxone did not reverse these effects. The patient fully recovered after appropriate supportive measures. A review of prior reports of xylazine exposure is provided.
authors.affiliation: Department of Pediatrics, University of Connecticut School of Medicine, and Connecticut Children's Medical Center, Hartford, Connecticut, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Capraro
authors.forename: J F
authors.initials: JF
authors.lastname: Wiley
authors.forename: J R
authors.initials: JR
authors.lastname: Tucker
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D062787:Drug Overdose / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders; D014991:Xylazine / Q000494:pharmacology / Q000506:poisoning*
chemical_list: D000316:Adrenergic alpha-Agonists; D014991:Xylazine