title: Alternative splicing and genome complexity.
abstract: Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.
authors.affiliation: Max Delbrück Center for Molecular Medicine, Robert-Rössle Strasse 10, Berlin-Buch, 13125 Germany.
authors.forename: David
authors.initials: D
authors.lastname: Brett
authors.forename: Heike
authors.initials: H
authors.lastname: Pospisil
authors.forename: Juan
authors.initials: J
authors.lastname: Valcárcel
authors.forename: Jens
authors.initials: J
authors.lastname: Reich
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D002417:Cattle; D020224:Expressed Sequence Tags; D014644:Genetic Variation / Q000235:genetics*; D016678:Genome; D006801:Humans; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats
chemical_list: D012333:RNA, Messenger