Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice.
Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg(-1), p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.
Premkumar
K
K
Department of Genetics, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600-113, India.
Pachiappan
A
A
Abraham
S K
SK
Santhiya
S T
ST
Gopinath
P M
PM
Ramesh
A
A
D000818:Animals; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D000458:Cyanobacteria; D003520:Cyclophosphamide; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D016685:Mitomycin; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D053545:Spirulina
D001426:Bacterial Proteins; D016685:Mitomycin; D003520:Cyclophosphamide