title: [Antioxidants ceruloplasmin and lactoferrin in the prevention and treatment of postoperative complications in cancer patients].
abstract: Ceruloplasmin and laprote based on natural protein antioxidants were used in the treatment and prevention of postoperative complications in 174 patients after extensive interventions for cancer. Development of pyoseptic complications during the postoperative period is associated with activation of lipid peroxidation, decreased functional activity of the antioxidant component of detoxication, suppressed T-cellular immunity, and development of polyorgan failure in the presence of endogenous toxemia. Systemic treatment with laprote (50 pts) and ceruloplasmin (33 pts) after surgical cleansing and draining of purulent focus stimulated activation of antioxidant defense, decreased the intensity of oxidative processes, normalized the lymphocytic component of immunity, and promoted resolution of polyorgan, primarily hepatic failure. Local therapy with laprote (60 pts) promoted rapid regression of local pyoinflammatory processes. Intraoperative blood loss complicated by hemorrhagic shock had a deep impact on the oxidative/antioxidant system, which correlated with the severity of hypoxia. Addition of ceruloplasmin, a potent antioxidant, to therapy of these patients (n = 31) optimized the course of recovery by stimulating the resolution of posthypoxic polyorgan failure, recovery of the oxidant/antioxidant balance, and decreasing the incidence of postoperative pyoinflammatory complications.
authors.forename: N V
authors.initials: NV
authors.lastname: Edeleva
authors.forename: T V
authors.initials: TV
authors.lastname: Sergeeva
authors.forename: E R
authors.initials: ER
authors.lastname: Nemtsova
authors.forename: I Ia
authors.initials: IIa
authors.lastname: Shcherbitskaia
authors.forename: R I
authors.initials: RI
authors.lastname: Iakubovskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Osipova
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D002570:Ceruloplasmin / Q000627:therapeutic use*; D003627:Data Interpretation, Statistical; D006801:Humans; D007781:Lactoferrin / Q000627:therapeutic use*; D015227:Lipid Peroxidation; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000517:prevention & control / Q000628:therapy; D009369:Neoplasms / Q000276:immunology / Q000601:surgery*; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D002570:Ceruloplasmin; D007781:Lactoferrin