title: In vitro potentiation of antibiotic activities by a catecholate iron chelator against chloroquine-resistant Plasmodium falciparum.
abstract: FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic effects in association with macrolides, ofloxacin, and rifampin.
authors.affiliation: Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, 13007 Marseille, France. bruno.pradines@free.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Pradines
authors.forename: Florence
authors.initials: F
authors.lastname: Ramiandrasoa
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Rolain
authors.forename: Christophe
authors.initials: C
authors.lastname: Rogier
authors.forename: Joel
authors.initials: J
authors.lastname: Mosnier
authors.forename: William
authors.initials: W
authors.lastname: Daries
authors.forename: Thierry
authors.initials: T
authors.lastname: Fusai
authors.forename: Gerhard
authors.initials: G
authors.lastname: Kunesch
authors.forename: Jacques
authors.initials: J
authors.lastname: Le Bras
authors.forename: Daniel
authors.initials: D
authors.lastname: Parzy
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004338:Drug Combinations; D004351:Drug Resistance / Q000502:physiology; D004357:Drug Synergism; D007502:Iron Chelating Agents / Q000494:pharmacology*; D018942:Macrolides; D009643:Norfloxacin / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D013095:Spermidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000962:Antimalarials; D004338:Drug Combinations; C108048:FR 160; D007502:Iron Chelating Agents; D018942:Macrolides; D002738:Chloroquine; D013752:Tetracycline; D009643:Norfloxacin; D013095:Spermidine