Measurement of flecainide in hair as an index of drug exposure.
We report a method for measuring the concentration of flecainide in hair. An animal study, in which flecainide (1, 5, and 10 mg/kg/day) was orally administered for 1, 2, and 3 weeks to pigmented rats, showed that flecainide concentration in rat hairs newly regrown after administration significantly correlated with both the daily dose and the dosing period. The part of hair containing flecainide continued to grow upward, retaining the drug within the hair structure that had been formed at the time of drug exposure. Flecainide was also determined in human scalp hairs collected from patients treated with flecainide. The drug content of white hairs was much less than that black hairs collected from the same rats and subjects, suggesting the determinant effect of hair pigment on flecainide accumulation in hair. These findings suggest that the analysis of flecainide in hair may be useful for assessing exposure to drug qualitatively.
Takiguchi
Y
Y
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan. takiguti@ph2.tokushima-u.ac.jp
Ishihara
R
R
Kato
R
R
Kamihara
S
S
Yokota
M
M
Uematsu
T
T
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000032:analysis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005424:Flecainide / Q000032:analysis* / Q000494:pharmacology; D006197:Hair / Q000737:chemistry* / Q000187:drug effects; D006801:Humans; D008297:Male; D051381:Rats; D012107:Research Design
D000889:Anti-Arrhythmia Agents; D005424:Flecainide