title: Late seizure recurrence after multiple subpial transections.
abstract: We studied long-term outcome (range, 28-89 months; mean, 56 months) after multiple subpial transections (MSTs) for medically refractory epilepsy. Forty-three (79.6%) of 54 patients had a consistent significant reduction in seizure frequency, and 27 (50%) of the 54 were either entirely seizure free or virtually so. However, 10 (18.6%) patients sustained an increase in seizure frequency several years after surgery, after showing initial postoperative improvement. This suggests that late seizure recurrence is a more important problem in cases in which MST has been performed than for pure resections.
authors.affiliation: Department of Neurology, NYU School of Medicine, New York, New York 10016, USA.
authors.forename: D
authors.initials: D
authors.lastname: Orbach
authors.forename: P
authors.initials: P
authors.lastname: Romanelli
authors.forename: O
authors.initials: O
authors.lastname: Devinsky
authors.forename: W
authors.initials: W
authors.lastname: Doyle
mesh_terms: D001369:Axons / Q000473:pathology / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012008:Recurrence; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery