title: Sporadic type composite pheochromocytoma with neuroblastoma: clinicomorphologic, DNA content and ret gene analysis.
abstract: Composite pheochromocytomas (CP) account for only 3% of all pheochromocytomas. We analyzed the clinical, immunohistochemical, ultrastructural, DNA content, and 634 ret mutation features in a 56-year-old Mexican woman with CP localized in the right adrenal gland and associated to a blood pressure of 140/90 mmHg. Clinical symptoms were absent after surgery. The tumor showed pheochromocytoma and neuroblastoma components. This dual phenotype was supported by light microscopy and corroborated by immunohistochemistry and ultrastructural findings. Flow cytometric analysis showed that both components were diploid. A genetic mutational analysis of the ret oncogene in exon 11 showed no 634 mutation. This case demonstrates the indolent behavior of neuroblastoma associated to a sporadic-type CP in an adult patient.
authors.affiliation: Department of Pathology, Oncology Hospital, Centro Médico Nacional Siglo XXI, IMSS. México, D.F. México. fcandanedo@hotmail.com
authors.forename: F A
authors.initials: FA
authors.lastname: Candanedo-González
authors.forename: I
authors.initials: I
authors.lastname: Alvarado-Cabrero
authors.forename: A
authors.initials: A
authors.lastname: Gamboa-Domínguez
authors.forename: A
authors.initials: A
authors.lastname: Cérbulo-Vázquez
authors.forename: R
authors.initials: R
authors.lastname: López-Romero
authors.forename: L
authors.initials: L
authors.lastname: Bornstein-Quevedo
authors.forename: M
authors.initials: M
authors.lastname: Salcedo-Vargas
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D029721:Drosophila Proteins; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology*; D009447:Neuroblastoma / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D010673:Pheochromocytoma / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D017931:DNA Primers; D004273:DNA, Neoplasm; D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila