Cyclodextrin dimers as cleavable carriers of photodynamic sensitizers.
Several phthalocyanines carrying hydrophobic components have been synthesized and shown to bind to a group of cyclodextrin dimers with a carbon-carbon double bond in the linker. The complexes are soluble in water. On irradiation in the presence of oxygen, the singlet oxygen produced cleaves the olefinic linkers in the complexes, resulting in precipitation of the sensitizers. This process concentrates the sensitizers in the light beam, a process that has useful potential in photodynamic therapy.
Baugh
S D
SD
Department of Chemistry, Columbia University, New York, New York 10027, USA.
Yang
Z
Z
Leung
D K
DK
Wilson
D M
DM
Breslow
R
R
D003505:Cyclodextrins / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D019281:Dimerization; D004337:Drug Carriers; D007211:Indoles / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D054833:Isoindoles; D007700:Kinetics; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D010777:Photochemistry; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry; D017967:Zinc Compounds
D003505:Cyclodextrins; D004337:Drug Carriers; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D017967:Zinc Compounds; D014867:Water; C052159:Zn(II)-phthalocyanine; D015032:Zinc; D010100:Oxygen