title: Improvement of anti-Hu-associated paraneoplastic sensory neuropathy after chemoradiotherapy in a small cell lung cancer patient.
abstract: A 66-year-old man developed progressive painful dysesthesia in his hands and feet over 3 months. His vibration sense was impaired and sensory nerve action potentials of the limbs were not evoked. Biopsy of the peroneal nerve revealed sensory neuropathy. Positive anti-Hu antibody facilitated delineation of a right hilar mass and a metastatic lymph node in thoracic CT scan. He was diagnosed as small cell lung cancer associated with paraneoplastic sensory neuropathy. A complete response was achieved through chemotherapy (carboplatin and etoposide) and subsequent radiation therapy. Notably, his neurological conditions, although not changed during the hospitalization, gradually improved afterwards.
authors.affiliation: Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita.
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: I
authors.initials: I
authors.lastname: Tachibana
authors.forename: H
authors.initials: H
authors.lastname: Fujimura
authors.forename: Y
authors.initials: Y
authors.lastname: Nakatsuji
authors.forename: F
authors.initials: F
authors.lastname: Sugai
authors.forename: I
authors.initials: I
authors.lastname: Naba
authors.forename: M
authors.initials: M
authors.lastname: Nakamori
authors.forename: H
authors.initials: H
authors.lastname: Morishita
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Osaki
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy*; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy*; D008297:Male; D020364:Paraneoplastic Polyneuropathy / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D005047:Etoposide; D016190:Carboplatin