IGFBP-1 and glycodelin serum levels before and after hysterectomy with and without bilateral oophorectomy in premenopausal women.
OBJECTIVE
The aim of our study was to investigate the role of the intact endometrium and ovaries for serum levels of insulin-like growth factor binding protein-1 (IGFBP-1) and glycodelin.


METHODS
In 35 premenopausal patients with a planned hysterectomy, serum measurements of IGFBP-1 and glycodelin were done before surgery and 1, 3, 5, and 10 days after surgery. Patients were divided into three groups according to the kind and time of operation: (1) hysterectomy with bilateral adnexectomy in the luteal phase and (2) hysterectomy without adnexectomy in the follicular phase or (3) the luteal phase.


RESULTS
IGFBP-1-we could not show any differences in IGFBP-1 serum levels before and after hysterectomy with or without bilateral oophorectomy. Glycodelin-hysterectomized and oophorectomized patients showed decreasing serum levels up to day 3. After day 5, circulating concentrations of glycodelin increased continuously but remained below pre-operative levels. In both non-adnexectomized groups we saw a reduction up to day 5 but a rise at day 10. None of the results reached statistical significance.


CONCLUSIONS
The results indicate that endometrium and ovary are not the only sources of IGFBP-1 and glycodelin.
Foth
D
D
Department of Obstetrics and Gynecology, University of Cologne, Kerpener Str. 34, 50931 Köln, Germany. dfoth@t-online.de
Meisel
M
M
Nawroth
F
F
Straube
W
W
Römer
T
T
D000328:Adult; D005260:Female; D005498:Follicular Phase; D000071816:Glycodelin; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007044:Hysterectomy; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D008183:Luteal Phase; D008875:Middle Aged; D010052:Ovariectomy; D011257:Pregnancy Proteins / Q000097:blood*; D017697:Premenopause
D000071816:Glycodelin; D006023:Glycoproteins; D018970:Insulin-Like Growth Factor Binding Protein 1; C045246:PAEP protein, human; D011257:Pregnancy Proteins