title: Sequential expression of annexin A5 in the vasculature and skeletal elements during mouse development.
abstract: Annexin A5 (annexin V, anchorin CII) represents the prototype member of the large annexin family, characterized by its ability to interact with phospholipids in a calcium-dependent manner and to form calcium-specific ion channels. Despite intense biochemical analysis, the in vivo expression and function of this annexin during mouse development, still remains unclear. Immunohistochemistry, in situ hybridization and reporter gene expression were used to define expression of annexin A5 during early mouse development. First, annexin A5 expression is associated with the developing vascular system. Later, expression is detected within the notochord and found in parallel to the differentiation of cartilage and bone. Therefore, expression of the Anxa5 gene may represent a novel marker characterizing cell lineages involved in the development of the vascular as well as the skeletal system.
authors.affiliation: Abteilung für Experimentelle Medizin I, Nikolaus-Fiebiger-Zentrum, Friedrich-Alexander Universität Erlangen-Nürnberg, Glückstrasse 6, 91054, Erlangen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Brachvogel
authors.forename: H
authors.initials: H
authors.lastname: Welzel
authors.forename: H
authors.initials: H
authors.lastname: Moch
authors.forename: K
authors.initials: K
authors.lastname: von der Mark
authors.forename: C
authors.initials: C
authors.lastname: Hofmann
authors.forename: E
authors.initials: E
authors.lastname: Pöschl
mesh_terms: D000818:Animals; D017304:Annexin A5 / Q000096:biosynthesis*; D001808:Blood Vessels / Q000196:embryology*; D001842:Bone and Bones / Q000196:embryology*; D019070:Cell Lineage; D017930:Genes, Reporter; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007763:Lac Operon; D051379:Mice; D008957:Models, Genetic; D011485:Protein Binding; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D017304:Annexin A5; D012333:RNA, Messenger