A new family of CoA-transferases.
CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.
Heider
J
J
Mikrobiologie, Institut für Biologie II, Universität Freiburg, Schänzlestr. 1, 79104 Freiburg, Germany. heiderj@uni-freiburg.de
D001421:Bacteria, Anaerobic / Q000201:enzymology*; D001426:Bacterial Proteins / Q000145:classification / Q000378:metabolism; D001667:Binding, Competitive; D015256:Coenzyme A-Transferases / Q000737:chemistry / Q000145:classification* / Q000378:metabolism*; D007700:Kinetics; D013379:Substrate Specificity; D013869:Thiolester Hydrolases / Q000145:classification / Q000378:metabolism
D001426:Bacterial Proteins; D015256:Coenzyme A-Transferases; D013869:Thiolester Hydrolases; C117493:bile acid-CoA hydrolase