title: The effect of alendronate (Fosamax) and implant surface on bone integration and remodeling in a canine model.
abstract: Patients at high risk for osteoporosis and its associated morbidity, including postmenopausal women, are being pharmacologically managed to stabilize and improve bone mass. Alendronate sodium (Fosamax) is a commonly used antiresorptive agent effective in osteopenic women for reducing bone resorption, increasing bone density, and decreasing fracture incidence. With the increased incidence of alendronate-treated women who are undergoing hip replacement or fracture repair by prosthesis placement, data are needed to predict how alendronate affects host bone integration with uncemented surfaces. The aim of this study was to determine the effect of alendronate on new bone formation and attachment to implant surfaces in a normal and simulated estrogen-deficient, calcium-deficient canine model, using an implantable bone growth chamber. Alendronate did not affect host bone integration to surfaces commonly used in uncemented total joint arthroplasty, but there were significant differences dependent solely on the type of surface.
authors.affiliation: Musculoskeletal Research Center and Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, New York 10003, USA. sally.frenkel@excite.com
authors.forename: S R
authors.initials: SR
authors.lastname: Frenkel
authors.forename: W L
authors.initials: WL
authors.lastname: Jaffe
authors.forename: C D
authors.initials: CD
authors.lastname: Valle
authors.forename: L
authors.initials: L
authors.lastname: Jazrawi
authors.forename: S
authors.initials: S
authors.lastname: Maurer
authors.forename: A
authors.initials: A
authors.lastname: Baitner
authors.forename: K
authors.initials: K
authors.lastname: Wright
authors.forename: D
authors.initials: D
authors.lastname: Sala
authors.forename: M
authors.initials: M
authors.lastname: Hawkins
authors.forename: P E
authors.initials: PE
authors.lastname: Di Cesare
mesh_terms: D019386:Alendronate / Q000494:pharmacology*; D000818:Animals; D019644:Arthroplasty, Replacement, Hip; D001860:Bone Plates; D016723:Bone Remodeling / Q000187:drug effects*; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D005269:Femur / Q000601:surgery* / Q000648:ultrastructure; D006801:Humans; D020007:Implants, Experimental; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000187:drug effects*; D010014:Osteolysis / Q000188:drug therapy; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy; D010052:Ovariectomy; D011475:Prosthesis Failure; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D019386:Alendronate