title: HLA class II alleles and salivary numbers of mutans streptococci and lactobacilli among young adults in Japan.
abstract: To investigate the genetic predisposition toward the accumulation of oral microorganisms, the association between the alleles of HLA-DQA1, -DQB1 and -DRB1 and the salivary numbers of mutans streptococci and lactobacilli were examined in 102 young adults in Japan. HLA-DQA1*0102, DQB1*0604, DRB1*0802, and DRB1*1302 were weakly associated with the numbers of lactobacilli in saliva samples (P<0.05). HLA-DQB1*0601 was associated with the salivary numbers of mutans streptococci (P<0.01). Two HLA class II haplotypes, HLA-[DRB1*0802-DQA1*0301-DQB1*0302] and HLA-[DRB1*1302-DQA1*0102-DQB1*0604], were also weakly associated with the salivary numbers of lactobacilli (P<0.05). These observations suggest that HLA class II alleles may be related to the salivary populations of oral microorganisms, such as mutans streptococci and lactobacilli.
authors.affiliation: Department of Preventive Dentistry, Tohoku University School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ozawa
authors.forename: J
authors.initials: J
authors.lastname: Chiba
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000483:Alleles; D016009:Chi-Square Distribution; D015169:Colony Count, Microbial; D016001:Confidence Intervals; D004245:DMF Index; D003731:Dental Caries / Q000382:microbiology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007778:Lactobacillus / Q000254:growth & development*; D008297:Male; D016017:Odds Ratio; D012463:Saliva / Q000382:microbiology*; D013223:Statistics as Topic; D013295:Streptococcus mutans / Q000254:growth & development*
chemical_list: D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II