New pharmacological strategies for the treatment of heart failure.
Heart failure still carries a high morbidity and mortality, necessitating new approaches for its management. Greater understanding of the pathophysiology of heart failure has opened the way for novel therapeutic approaches, including analogs of natriuretic peptides and drugs that modulate endothelin, cytokine release and endothelial vasoconstriction. Other drugs are undergoing laboratory and clinical trials that will eventually supersede or complement less optimal heart failure treatments. Clinical trials will ascertain if these new strategies in the treatment of heart failure will ultimately be successful in the management of these patients.
Chin
B S
BS
University Department of Medicine, City Hospital, Birmingham.
Lip
G Y
GY
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D009320:Atrial Natriuretic Factor / Q000378:metabolism / Q000502:physiology / Q000627:therapeutic use; D000077300:Bosentan; D002118:Calcium / Q000378:metabolism; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D019332:Endothelin-1 / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D006835:Hydrazones / Q000627:therapeutic use; D009124:Muscle Proteins / Q000378:metabolism; D015260:Neprilysin / Q000037:antagonists & inhibitors; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D011724:Pyridazines / Q000627:therapeutic use; D000077464:Simendan; D013449:Sulfonamides / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002316:Cardiotonic Agents; D019332:Endothelin-1; D006835:Hydrazones; D009124:Muscle Proteins; D010726:Phosphodiesterase Inhibitors; D011724:Pyridazines; D013449:Sulfonamides; D014409:Tumor Necrosis Factor-alpha; D000077464:Simendan; C041648:pimobendan; D009320:Atrial Natriuretic Factor; D015260:Neprilysin; D000077300:Bosentan; D002118:Calcium