Activity of the cyclic depsipeptide emodepside (BAY 44-4400) against larval and adult stages of nematodes in rodents and the influence on worm survival.
The present investigations deal with the activity of the cyclic depsipeptide emodepside (BAY 44-4400) against larval and adult stages of three rodent nematodes. While emodepside acts strongly against the adult stages of the rat nematodes Nippostrongylus brasiliensis and Strongyloides ratti, as well as against the mouse nematode Heligmosomoides polygyrus, its actions against the larval stages of these nematodes vary according to the species. Thus, emodepside is highly effective against the lung and intestine larval stages of N. brasiliensis and S. ratti. By contrast. the larval stages of H. polygyrus in the intestine are only partly affected by higher emodepside dosages.
Harder
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A
Business Group Animal Health, Research and Development, Biological Chemical Evaluation, Bayer AG, Monheim, Germany. achim.harder.ah@bayer-ag.de
von Samson-Himmelstjerna
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G
D000818:Animals; D005260:Female; D005369:Filaricides / Q000627:therapeutic use*; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D008136:Longevity / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009351:Nematospiroides dubius / Q000187:drug effects* / Q000235:genetics; D009559:Nippostrongylus / Q000187:drug effects* / Q000254:growth & development; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D017206:Strongylida Infections / Q000188:drug therapy*; D017170:Strongyloides ratti / Q000187:drug effects / Q000235:genetics*
C439266:Bay 44-4400; D005369:Filaricides; D010456:Peptides, Cyclic