title: Constituents and pharmacological effects of Eucommia and Siberian ginseng.
abstract: The bark and leaves of Eucommia ulmoides Oliv (Eucommiaceae) and "Siberian ginseng" (Ezoukogi in Japanese) prepared from the root bark or stem bark of Eleutherococcus senticosus Maxim (Acanthopanax senticosus Harms) have been used as tonic and anti-stress drug. The extracts of Eucommia showed anti-hypertensive, anti-complementary, anti-oxidative, and anti-gastric ulcer effects, and promoting collagen synthesis, accelating granuloma formation, and other pharmacological effects. The Siberian ginseng exhibited anti-fatigue, anti-stress, immuno-enhancing effect, CNS activity, and anti-depressive effect. By now, 40, 28, and 10 compounds have been isolated from Eucommia ulmoides bark, Eucommia ulmoides leaves, and Siberian ginseng, respectively, and their structures were elucidated. Their pharmacological activities were mainly due to lignans and iridoid glycosides.
authors.affiliation: Central Research Laboratories, Yomeishu Seizo Co Ltd, Minowa-Machi, Kamiina-Gun, Nagano 399-4601, Japan. ymscrl@avis.ne.jp.
authors.forename: T
authors.initials: T
authors.lastname: Deyama
authors.forename: S
authors.initials: S
authors.lastname: Nishibe
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazawa
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D003094:Collagen / Q000096:biosynthesis / Q000187:drug effects; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology; D003863:Depression / Q000188:drug therapy; D028001:Eleutherococcus / Q000737:chemistry*; D031283:Eucommiaceae / Q000737:chemistry*; D005221:Fatigue / Q000188:drug therapy; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D057888:Iridoid Glucosides; D039823:Iridoids / Q000302:isolation & purification / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013312:Stress, Physiological / Q000188:drug therapy
chemical_list: D000276:Adjuvants, Immunologic; D000897:Anti-Ulcer Agents; D000959:Antihypertensive Agents; D000975:Antioxidants; D003374:Coumarins; D005663:Furans; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D017705:Lignans; D010936:Plant Extracts; C042192:syringaresinol; C058966:geniposidic acid; C008182:isofraxidin; D003094:Collagen