Unusual etiology of visual loss in an HIV-infected patient due to endogenous endophthalmitis.
Disseminated candidiasis, especially ocular infections such as endophthalmitis, is uncommon in HIV-infected patients. We report a case of candidal endophthalmitis in an HIV-positive non-drug-user patient, following candidemia from a cutaneous abscess at the site of a peripheral catheter. Ocular disease was revealed by a visual decrease in the left eye. DNA analysis using RAPD showed identical patterns of Candida albicans isolated from the skin and eye. Combination therapy with high-dose fluconazole and intravenous amphotericin B was performed. Two intravitreal amphotericin B injections and a vitrectomy were administered because of an amblyopic right eye and severe vitritis. The outcome was favorable without relapse at 18 months.
Miailhes
P
P
Department of Internal Medicine, Hôpital Antoine Béclère, Clamart, Department of Hepatogastroenterology, Hôtel-Dieu, 1 place de l'hôpital, 69288 Lyon cedex 2, France. patrick.miailhes@chu-lyon.fr
Labetoulle
M
M
Naas
T
T
Guibert
M
M
Bourée
P
P
Frau
E
E
Nordmann
P
P
Galanaud
P
P
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000328:Adult; D002176:Candida albicans / Q000235:genetics / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis* / Q000382:microbiology; D009877:Endophthalmitis / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D008297:Male; D014786:Vision Disorders / Q000382:microbiology*