Safety and immunogenicity in neonatal mice of a hyperattenuated Listeria vaccine directed against human immunodeficiency virus.
CD8(+) T cells are a major component of the adaptive response of a host to infections by viruses and other intracellular pathogenic agents. However, because of the intrinsic immaturity of the immune system of neonatal animals, neonates are highly sensitive to a variety of pathogens and may be unable to respond in a protective manner. Here we explore whether a hyperattenuated strain of Listeria monocytogenes that can be used as a live vaccine vector in adults is safe and able to induce an effective response in neonates. We answer both questions affirmatively.
Rayevskaya
Marina
M
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Kushnir
Natasha
N
Frankel
Fred R
FR
D016915:AIDS Vaccines / Q000009:adverse effects* / Q000235:genetics / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology* / Q000382:microbiology / Q000821:virology; D005260:Female; D015683:Gene Products, gag / Q000235:genetics / Q000276:immunology; D005818:Genetic Engineering; D015488:HIV Antigens / Q000235:genetics / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D008089:Listeria monocytogenes / Q000235:genetics* / Q000502:physiology; D008297:Male; D051379:Mice; D015996:Survival Rate; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014613:Vaccines, Attenuated / Q000009:adverse effects* / Q000235:genetics / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000235:genetics / Q000276:immunology
D016915:AIDS Vaccines; D015683:Gene Products, gag; D015488:HIV Antigens; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic