A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles.
OBJECTIVE
To compare the efficacy of Crinone 8% intravaginal progesterone gel vs. IM progesterone for luteal phase and early pregnancy support after IVF-ET.


METHODS
Randomized, open-label study.


METHODS
Academic medical center.


METHODS
Two hundred and one women undergoing IVF-ET.


METHODS
Women were randomized to supplementation with Crinone 8% (90 mg once daily) or IM progesterone (50 mg once daily) beginning the day after oocyte retrieval.


METHODS
Pregnancy, embryo implantation, and live birth rates.


RESULTS
The women randomized to luteal phase supplementation with IM progesterone had significantly higher clinical pregnancy (48.5% vs. 30.4%; odds ratio [OR], 2.16; 95% confidence interval [CI], 1.21, 3.87), embryo implantation (24.1% vs. 17.5%; OR, 1.89; 95% CI, 1.08, 3.30), and live birth rates (39.4% vs. 24.5%; OR, 2.00; 95% CI, 1.10, 3.70) than women randomized to Crinone 8%.


CONCLUSIONS
In women undergoing IVF-ET, once-a-day progesterone supplementation with Crinone 8%, beginning the day after oocyte retrieval, resulted in significantly lower embryo implantation, clinical pregnancy, and live birth rates compared with women supplemented with IM progesterone.
Propst
A M
AM
Center for Reproductive Medicine, Division of Reproductive Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Hill
J A
JA
Ginsburg
E S
ES
Hurwitz
S
S
Politch
J
J
Yanushpolsky
E H
EH
D000282:Administration, Intravaginal; D000328:Adult; D000367:Age Factors; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005782:Gels / Q000008:administration & dosage; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D018709:Statistics, Nonparametric
C400424:Crinone; D005782:Gels; D011374:Progesterone; D004958:Estradiol