The antibacterial activity of triclosan-impregnated storage boxes against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus and Shewanella putrefaciens in conditions simulating domestic use.
Antimicrobial resistance has increased over the past decade causing concern for public health. Domestic antimicrobial products containing triclosan (2,4,4'-trichloro-2'-hydroxydiphenylether), a broad-spectrum antibacterial agent, were introduced in 1997 and have become popular among consumers. Cross-resistance to other antibacterial agents has been suggested as a possible consequence of their widespread use. Triclosan-impregnated plastic storage boxes were tested for activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus and Shewanella putrefaciens in various conditions, including some designed to simulate usual storage conditions. Results showed inhibition up to a factor of 106 of bacteria grown in direct contact with triclosan-impregnated plastic at 30 and 22 degrees C, but not at 4 degrees C. Triclosan resistance was not found to increase after repeated exposure in triclosan-impregnated boxes. Further investigation into the effect of triclosan-impregnated products on bacteria will increase understanding of domestic antimicrobial products and implications of their overuse.
Braid
Josephine J
JJ
Department of Microbiology & PHLS Antimicrobial Susceptibility Surveillance Unit, Queens Medical Centre, Nottingham NG7 2UH, UK.
Wale
Martin C J
MC
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects* / Q000254:growth & development; D015169:Colony Count, Microbial / Q000379:methods / Q000706:statistics & numerical data; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D019064:Product Packaging / Q000379:methods / Q000706:statistics & numerical data; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D020614:Shewanella putrefaciens / Q000187:drug effects* / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013696:Temperature; D014260:Triclosan / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D014260:Triclosan