Gatifloxacin efficacy in treatment of experimental methicillin-sensitive Staphylococcus aureus-induced osteomyelitis in rabbits.
The effectiveness of oral gatifloxacin was compared to that of standard parenteral antibiotic therapy (nafcillin) for the treatment of experimental methicillin-sensitive Staphylococcus aureus-induced osteomyelitis in a rabbit model. Gatifloxacin was as effective as nafcillin in clearing the infection. Therefore, oral gatifloxacin treatment of osteomyelitis may be an effective alternative to intravenous nafcillin treatment.
Shirtliff
Mark E
ME
Center for Biofilm Engineering, Montana State University, Bozeman, Montana 59717-3980, USA. mshirtliff@erc.montana.edu
Calhoun
Jason H
JH
Mader
Jon T
JT
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D008712:Methicillin / Q000494:pharmacology; D009254:Nafcillin / Q000627:therapeutic use; D010019:Osteomyelitis / Q000188:drug therapy*; D010406:Penicillins / Q000627:therapeutic use; D011817:Rabbits; D013211:Staphylococcus aureus / Q000187:drug effects; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010406:Penicillins; D009254:Nafcillin; D000077734:Gatifloxacin; D008712:Methicillin