title: Increase of the adenallene anti-HIV activity in cell culture using its bis(tBuSATE) phosphotriester derivative.
abstract: The bis(S-pivaloyl-2-thioethyl) phosphotriester derivative of 9-(4'-hydroxy-1',2'-butadienyl)adenine (adenallene) was synthesized. This mononucleotide prodrug proved to be more effective than the parent nucleoside in inhibiting HIV-1 replication in several human T4 lymphoblastoid cell lines.
authors.affiliation: UMR CNRS 5625, Université Montpellier II, cc 008, Place E. Bataillon, 34095 Montpellier Cedex 5, France.
authors.forename: David
authors.initials: D
authors.lastname: Egron
authors.forename: Christian
authors.initials: C
authors.lastname: Périgaud
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Aubertin
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Gatanaga
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mitsuya
authors.forename: Jiri
authors.initials: J
authors.lastname: Zemlicka
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Imbach
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004952:Esters; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D004952:Esters; D018894:Reverse Transcriptase Inhibitors; C056909:adenallene; D000225:Adenine