5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report.
BACKGROUND
Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood.


METHODS
A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed. Electrocardiographs highlighting the severity of the presentation are included in the report along with coronary angiograms demonstrating the absence of significant coronary atherosclerosis.


CONCLUSIONS
Severe 5-fluorouracil-induced cardiotoxicity is rare, but can be severe and may mimic acute myocardial infarction, leading to diagnostic and therapeutic dilemmas. Readministration of 5-fluorouracil is not advised following an episode of cardiotoxicity.
McGlinchey
P G
PG
Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, BT12 6BA, UK. paulmcglinchey@hotmail.com
Webb
S T
ST
Campbell
N P
NP
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002637:Chest Pain / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005472:Fluorouracil / Q000009:adverse effects*; D006331:Heart Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil