Relationship between adequacy of dialysis and nutritional status, and their impact on patient survival on CAPD in Hong Kong.
OBJECTIVE
Superior patient survival on continuous ambulatory peritoneal dialysis (CAPD) with 3 x 2-L exchanges has been reported from Hong Kong. This study examined the relationship between indices of dialysis adequacy and nutrition and patient survival on CAPD in Hong Kong.


METHODS
A cross-sectional study on prevalent CAPD patients. Patients were assessed for indices of dialysis adequacy and nutritional status with a composite nutritional index (CNI). Patients were then followed for 24 months. Survival data were analyzed according to adequacy indices and nutritional status.


METHODS
All prevalent CAPD patients in nine dialysis centers in Hong Kong as of 1 April 1996.


METHODS
Mortality.


RESULTS
937 patients were assessed: 68.2% were using 3 x 2-L exchanges per day; mean age was 54.6 +/- 13 years. Mean total Kt/V was 1.83 +/- 0.42 and total creatinine clearance was 55.6 +/- 19.5 L/week/1.73 m2. 19% of patients were moderately to severely malnourished according to the CNI. There was no significant correlation between indices of adequacy and serum albumin or CNI. The 1- and 2-year patient survival from the time of assessment was 90.9% and 79.8%. There was a trend toward better survival in patients with Kt/V greater than 2.0, but it was not statistically significant. Peritoneal Kt/V did not impact survival in anuric patients. Malnourished patients had poorer survival than patients who were better nourished (p = 0.0259). After adjusting for age and diabetes, CNI was predictive of mortality but Kt/V and creatinine clearance were not.


CONCLUSIONS
This study demonstrates the importance of nutritional status over adequacy indices in predicting patient survival. There was a lack of correlation between nutritional status and conventional indices of dialysis adequacy.
Lo
W K
WK
Renal Unit of Tung Wah Hospital, University of Hong Kong, Hong Kong. wkloc@hkucc.hku.hk
Tong
K L
KL
Li
C S
CS
Chan
T M
TM
Wong
A K
AK
Ho
Y W
YW
Cheung
K O
KO
Kwan
T H
TH
Wong
K S
KS
Ng
F S
FS
Cheng
I K
IK
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D003404:Creatinine / Q000378:metabolism* / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000401:mortality* / Q000628:therapy; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000401:mortality* / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*; D015996:Survival Rate
D012709:Serum Albumin; D003404:Creatinine