Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs.
Phosphatidylinositol (PtdIns) 3-kinase (PI 3-kinase) activity has been implicated in fundamental cellular functions such as endosomal trafficking, growth-factor receptor signal transduction, and cell survival. This multiplicity of actions can be attributed to the existence of three classes of PI 3-kinases in mammalian cells, which can together lead to the production of four known distinct end products: PtdIns(3)P, PtdIns(3,4)P2, PtdIns(3,4,5)P3 and PtdIns(3,5)P2. The challenge of deciphering the connection between PI 3-kinase activity, the production of specific phosphoinositides and the control of specific cellular events is being met with the discovery of novel structural motifs that interact specifically with distinct PI 3-kinase products.
Corvera
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Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01615, USA. silvia.corvera@umassmed.edu
D000818:Animals; D001665:Binding Sites; D001798:Blood Proteins / Q000737:chemistry; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry* / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010750:Phosphoproteins / Q000737:chemistry; D017434:Protein Structure, Tertiary; D015398:Signal Transduction
D001798:Blood Proteins; D018129:Phosphatidylinositol Phosphates; D010750:Phosphoproteins; C055525:phosphatidylinositol 3-phosphate; C039077:platelet protein P47; D019869:Phosphatidylinositol 3-Kinases