Systemic inflammatory response syndrome, sepsis, and multiple organ dysfunction.
Companion animals with sepsis and multiple organ dysfunction can be the most challenging of all patients to treat. Current research in humans and laboratory models offers some exciting insights into the pathophysiology behind some of our most frustrating clinical challenges. This article applies several current concepts to a clinical case of pancreatitis and secondary sepsis to illustrate some of the cardiovascular, immune, and coagulation abnormalities commonly seen.
Brady
C A
CA
Section of Critical Care, Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA. cbrady@vet.upenn.edu
Otto
C M
CM
D000818:Animals; D016470:Bacteremia / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D002371:Cat Diseases / Q000175:diagnosis* / Q000628:therapy*; D002415:Cats; D004283:Dog Diseases / Q000175:diagnosis* / Q000628:therapy*; D004285:Dogs; D004638:Emergency Treatment / Q000662:veterinary; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*