[Prenatal effects of acetylsalicylic acid].
Acetylsalicylic acid is frequently ingested over-the-counter (OTC) drug, either as single or in combination with other drugs. It has been used in various diseases including that complicated pregnancy, such as preeclampsia and fetal grow retardation. Analgesic, antipyretic, especially anti-inflammatory activity occurs in high therapeutic doses. In low-dose acetylsalicylic acid is used to block production of thromboxane A2. Big epidemiological data suggest that low-dose of acetylsalicylic acid, even taken chronically, is safe for mother and fetus. However, animal and various human data have shown that high doses of the drug could produce different congenital malformations. The current literature suggests that acetylsalicylic acid should be given in pregnancy only if the potential benefit justifies the potential risk to the fetus. Anti-inflammatory doses should be stopped in the third trimester of gestation or given if the drug is needed in life-threatening situation or for serious disease for which safer drugs can not be used or are ineffective.
Burdan
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Pracownia Teratologii Doświadczalnej, Katedrze i Zakładzie Anatomii Prawidłowej Człowieka Akademii Medycznej w Lublinie. frank@tkt.net.pl
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011247:Pregnancy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin