Mechanisms of epileptogenicity in focal malformations caused by abnormal cortical development.
In this article, the authors review the cellular mechanisms of epileptogenicity in malformations caused by abnormalities of cortical development as related to neuronal excitation, reduced inhibition, disorganized synaptic connections, and glial function (or dysfunction).
Ying
Zhong
Z
Section of Epilepsy, Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. yingz@ccf.org
Najm
Imad M
IM
D000818:Animals; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology; D004195:Disease Models, Animal; D004828:Epilepsies, Partial / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D017981:Receptors, Neurotransmitter / Q000235:genetics
D017981:Receptors, Neurotransmitter