Unfolding rates for the diffusion-collision model.
In the diffusion-collision model, the unfolding rates are given by the likelihood of secondary structural cluster dissociation. In this work, we introduce an unfolding rate calculation for proteins whose secondary structural elements are alpha helices, modeled from thermal escape over a barrier that arises from the free energy in buried hydrophobic residues. Our results are in good agreement with currently accepted values for the attempt rate.
Beck
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Molecular Modeling Laboratory, Department of Physics and Astronomy, Tufts University, Medford, Massachusetts 02155, USA.
Siemens
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D055592:Biophysical Phenomena; D001703:Biophysics; D008958:Models, Molecular; D011489:Protein Denaturation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics
D011506:Proteins