Hypotensive effect of chemical constituents from Aloe barbadensis.
Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of elgonica dimer A (1).
Saleem
R
R
Dr. H.M.I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan. rs127pk@yahoo.com
Faizi
S
S
Siddiqui
B S
BS
Ahmed
M
M
Hussain
S A
SA
Qazi
A
A
Dar
A
A
Ahmad
S I
SI
Qazi
M H
MH
Akhtar
S
S
Hasnain
S N
SN
D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004642:Emodin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D028321:Plant Preparations / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats
D000880:Anthraquinones; D000959:Antihypertensive Agents; D005960:Glucosides; D028321:Plant Preparations; C459214:elgonica dimer A; C059635:aloe emodin anthrone; D004642:Emodin; C006457:alloin