Neuroleptic malignant syndrome during zuclopenthixol therapy in X-linked cerebral adrenoleukodystrophy.
An 8 year-old boy with X-ALD under treatment with simvastatin developed a severe adverse reaction when the dose of his other medication, zuclopenthixol was increased. Both drugs were withdrawn after a diagnosis of neuroleptic malignant syndrome was made.
Rubio-Gozalbo
M E
ME
Department of Paediatrics, University Hospital Maastricht, The Netherlands. mrub@skin.azm.nl
van Waardenburg
D A
DA
Forget
P P
PP
Spaapen
L J
LJ
Verrips
A
A
Vroomen
P C
PC
D000326:Adrenoleukodystrophy / Q000150:complications / Q000235:genetics*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002653:Child Behavior Disorders / Q000188:drug therapy / Q000523:psychology; D003006:Clopenthixol / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000150:complications / Q000235:genetics*; D019821:Simvastatin / Q000627:therapeutic use
D014150:Antipsychotic Agents; D003006:Clopenthixol; D019821:Simvastatin