Adoptive immunotherapy of alcoholism in C57BL/6 mice with splenocytes extracorporeally stimulated with reaferon.
Experiments on C57Bl/6 mice maintained under conditions of free-choice between ethanol and water for 12 months showed that adoptive transfer of splenocytes extracorporeally stimulated with reaferon suppressed alcohol consumption within 1 month.
Davydova
T V
TV
Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Fomina
V G
VG
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000427:Alcohol Deterrents / Q000494:pharmacology; D000428:Alcohol Drinking; D000437:Alcoholism / Q000628:therapy*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology; D007167:Immunotherapy; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins; D013154:Spleen / Q000166:cytology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000427:Alcohol Deterrents; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D000431:Ethanol