Host-Salmonella interaction: human trials.
Human clinical trials, including experimental challenges of volunteers with pathogenic Salmonella enterica serovar Typhi, small phase I and II trials that monitor the immune responses to vaccines, and large-scale controlled field trials that assess vaccine efficacy under conditions of natural challenge, have helped elucidate the interactions between Salmonella typhi and human hosts.
Levine
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MM
Center for Vaccine Development, University of Maryland School of Medicine, 685 W. Baltimore St., Baltimore, MD 21201, USA. mlevine@medicine.umaryland.edu
Tacket
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CO
Sztein
M B
MB
D000907:Antibodies, Bacterial / Q000097:blood; D002986:Clinical Trials as Topic; D006801:Humans; D012485:Salmonella typhi / Q000276:immunology / Q000472:pathogenicity*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014435:Typhoid Fever / Q000276:immunology* / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D000907:Antibodies, Bacterial; D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated