title: Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection.
abstract: Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation. We have demonstrated in vitro and in vivo that synthetic polyamine analogs are effective antimicrosporidial agents with a broad therapeutic window. CD8-knockout mice or nude mice infected with the microsporidian Encephalitozoon cuniculi were cured when they were treated with four different novel polyamine analogs at doses ranging from 1.25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died.
authors.affiliation: Haskins Laboratories and Department of Biology, Pace University, New York, New York 10038-1598, USA. cbacchi@pace.edu
authors.forename: Cyrus J
authors.initials: CJ
authors.lastname: Bacchi
authors.forename: Louis M
authors.initials: LM
authors.lastname: Weiss
authors.forename: Schenella
authors.initials: S
authors.lastname: Lane
authors.forename: Benjamin
authors.initials: B
authors.lastname: Frydman
authors.forename: Aldonia
authors.initials: A
authors.lastname: Valasinas
authors.forename: Venodhar
authors.initials: V
authors.lastname: Reddy
authors.forename: Jerry S
authors.initials: JS
authors.lastname: Sun
authors.forename: Laurence J
authors.initials: LJ
authors.lastname: Marton
authors.forename: Imitiaz A
authors.initials: IA
authors.lastname: Khan
authors.forename: Magali
authors.initials: M
authors.lastname: Moretto
authors.forename: Nigel
authors.initials: N
authors.lastname: Yarlett
authors.forename: Murray
authors.initials: M
authors.lastname: Wittner
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D009670:Encephalitozoon cuniculi / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D016881:Microsporidiosis / Q000188:drug therapy*; D021261:Parasitic Sensitivity Tests; D011073:Polyamines / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011073:Polyamines