title: Temperature dependence of unbinding forces between complementary DNA strands.
abstract: Force probe techniques such as atomic force microscopy can directly measure the force required to rupture single biological ligand receptor bonds. Such forces are related to the energy landscape of these weak, noncovalent biological interactions. We report unbinding force measurements between complementary strands of DNA as a function of temperature. Our measurements emphasize the entropic contributions to the energy landscape of the bond.
authors.affiliation: Department of Physics and Astronomy, National Center of Competence in Research on Nanoscale Science, University of Basel, CH-4056 Basel, Switzerland.
authors.forename: Irina
authors.initials: I
authors.lastname: Schumakovitch
authors.forename: Wilfried
authors.initials: W
authors.lastname: Grange
authors.forename: Torsten
authors.initials: T
authors.lastname: Strunz
authors.forename: Patricia
authors.initials: P
authors.lastname: Bertoncini
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Güntherodt
authors.forename: Martin
authors.initials: M
authors.lastname: Hegner
mesh_terms: D001483:Base Sequence; D018076:DNA, Complementary / Q000737:chemistry*; D018625:Microscopy, Atomic Force / Q000379:methods; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D011336:Probability; D013696:Temperature; D013816:Thermodynamics
chemical_list: D018076:DNA, Complementary; D009838:Oligodeoxyribonucleotides