Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice.
One of the most severe side effects of anti-tumour chemotherapy is mucositis due to drug toxicity for rapidly dividing cells. We show here that anti-DXR monoclonal antibodies can prevent DXR-induced damage. Indeed, apoptosis, confined to the proliferative compartment of the basal mucosa, observed in the tongue of DXR-treated mice was completely inhibited by topical application of the anti-DXR antibodies.
Balsari
A
A
Institute of Pathology, Faculty of Medicine, Milan University, Milan, Italy.
Rumio
C
C
Morelli
D
D
Sfondrini
L
L
Nardini
E
E
Barajon
I
I
Ménard
S
S
D000287:Administration, Topical; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000276:immunology* / Q000633:toxicity; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D000918:Antibody Specificity; D017209:Apoptosis / Q000187:drug effects*; D004317:Doxorubicin / Q000276:immunology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005260:Female; D005928:Glossitis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D013280:Stomatitis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D014059:Tongue / Q000187:drug effects / Q000473:pathology
D000903:Antibiotics, Antineoplastic; D000911:Antibodies, Monoclonal; D004317:Doxorubicin