title: A man with hereditary exostoses and high-grade non-Hodgkin's lymphoma of the bone.
abstract: Multiple cartilaginous exostoses (MCE) is an autosomal dominant disorder that can lead to malignant transformation from exostoses to a secondary chondrosarcoma. We present a case report of a 52-year-old man with MCE who had a palpable mass at the left shoulder. At the site of the left proximal humerus, a cartilaginous exostosis was localized, suggesting that the tumor developed by a malignant transformation of an exostosis into a secondary chondrosarcoma. Interestingly, a biopsy showed a diffuse large B-cell lymphoma with Burkitt-like features. To our knowledge, the association of high-grade lymphoma and hereditary exostoses has not been described previously. This case demonstrates that a malignant tumor at the location of a cartilaginous exostosis is not necessarily a chondrosarcoma and that a biopsy is an essential part of the diagnostic work-up.
authors.affiliation: Department of Internal Medicine V, University of Heidelberg, Germany. k.neben@dkfz.de
authors.forename: K
authors.initials: K
authors.lastname: Neben
authors.forename: M
authors.initials: M
authors.lastname: Werner
authors.forename: L
authors.initials: L
authors.lastname: Bernd
authors.forename: V
authors.initials: V
authors.lastname: Ewerbeck
authors.forename: G
authors.initials: G
authors.lastname: Delling
authors.forename: A D
authors.initials: AD
authors.lastname: Ho
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002813:Chondrosarcoma / Q000175:diagnosis; D003937:Diagnosis, Differential; D005097:Exostoses, Multiple Hereditary / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed