title: First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants.
abstract: Compounds combining NK(1) antagonism and serotonin reuptake inhibition are described, and potentially represent a new generation of antidepressants. Compound 24 displays good affinities for both the NK(1) receptor and the serotonin reuptake site (32 and 25 nM, respectively).
authors.affiliation: Chemical Research, R&D, UCB Pharma SA, Chemin du Foriest, B-1420 Braine-l'Alleud, Belgium. thomas.ryckmans@ucb-group.com
authors.forename: Thomas
authors.initials: T
authors.lastname: Ryckmans
authors.forename: Laurent
authors.initials: L
authors.lastname: Balançon
authors.forename: Olivier
authors.initials: O
authors.lastname: Berton
authors.forename: Christophe
authors.initials: C
authors.lastname: Genicot
authors.forename: Yves
authors.initials: Y
authors.lastname: Lamberty
authors.forename: Benedicte
authors.initials: B
authors.lastname: Lallemand
authors.forename: Patrick
authors.initials: P
authors.lastname: Pasau
authors.forename: Nathalie
authors.initials: N
authors.lastname: Pirlot
authors.forename: Luc
authors.initials: L
authors.lastname: Quéré
authors.forename: Patrice
authors.initials: P
authors.lastname: Talaga
mesh_terms: D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D064729:Neurokinin-1 Receptor Antagonists; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000928:Antidepressive Agents; D064729:Neurokinin-1 Receptor Antagonists; D017367:Selective Serotonin Reuptake Inhibitors