Cytokines in host defense against Salmonella.
Cytokines are key communication molecules between host cells in the defense against the enteric pathogen, Salmonella. Infection with Salmonella induces expression of multiple chemokines and proinflammatory cytokines in cultured intestinal epithelial cells and macrophages. In animal models, protective roles have been shown for IL-1alpha, TNFalpha, IFN-gamma, IL-12, IL-18 and IL-15, whereas IL-4 and IL-10 inhibit host defenses against Salmonella.
Eckmann
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L
Department of Medicine 0623D, Laboratory of Mucosal Immunology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0623, USA. leckmann@ucsd.edu
Kagnoff
M F
MF
D000818:Animals; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D004195:Disease Models, Animal; D004848:Epithelium / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate; D007422:Intestines / Q000166:cytology / Q000382:microbiology; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D012475:Salmonella / Q000472:pathogenicity* / Q000502:physiology; D012480:Salmonella Infections / Q000276:immunology* / Q000382:microbiology
D016207:Cytokines