title: Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein-Barr virus animal model.
abstract: We sequenced the rhesus lymphocryptovirus (LCV) genome in order to determine its genetic similarity to Epstein-Barr virus (EBV). The rhesus LCV encodes a repertoire identical to that of EBV, with 80 open reading frames, including cellular interleukin-10, bcl-2, and colony-stimulating factor 1 receptor homologues and an equivalent set of viral glycoproteins. The highly conserved rhesus LCV gene repertoire provides a unique animal model for the study of EBV pathogenesis.
authors.affiliation: Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Pierre
authors.initials: P
authors.lastname: Rivailler
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Young-gyu
authors.initials: YG
authors.lastname: Cho
authors.forename: Carol
authors.initials: C
authors.lastname: Quink
authors.forename: Fred
authors.initials: F
authors.lastname: Wang
mesh_terms: D000818:Animals; D001483:Base Sequence; D016679:Genome, Viral; D018143:Lymphocryptovirus / Q000235:genetics*; D008253:Macaca mulatta; D016366:Open Reading Frames; D017385:Sequence Homology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins