Synthesis and antinephritic activities of quinoline-3-carboxamides and related compounds.
A series of linomide-related quinoline-3-carboxamides and their analogues was prepared and evaluated for antinephritic activities. The 6-MeS derivative 7a was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.
Tsuji
Kiyoshi
K
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, 1-6, Kashima 2-chome,Yodogawa-ku, 532-8514, Osaka, Japan. kiyoshi_tsuji@po.fujisawa.co.jp
Spears
Glen W
GW
Nakamura
Katsuya
K
Tojo
Takashi
T
Seki
Nobuo
N
Sugiyama
Aiko
A
Matsuo
Masaaki
M
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000974:Antibodies, Antinuclear / Q000187:drug effects; D001327:Autoimmune Diseases / Q000188:drug therapy; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006086:Graft vs Host Disease / Q000188:drug therapy; D051379:Mice; D019463:Mice, Inbred MRL lpr; D009393:Nephritis / Q000188:drug therapy*; D011507:Proteinuria / Q000188:drug therapy; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000577:Amides; D000974:Antibodies, Antinuclear; D011804:Quinolines