title: Possible genetic link between eating disorders and seasonal changes in mood and behavior.
abstract: Studies suggest that there is a seasonal pattern of mood fluctuations and eating behavior in patients with eating disorders. Multiple lines of evidence suggest that serotonergic pathways are involved in the mechanisms of eating disorders and seasonal changes in mood and behavior. Researchers have investigated whether variants of genes related to serotonergic transmission are associated with seasonal affective disorder (SAD) and eating disorders. There is evidence that the -1438G/A promoter polymorphism of the 5-HT2A gene plays a role in the development of SAD and eating disorders. Variation of the tryptophan hydroxylase gene may play a part in eating behavior and weight regulation in females with SAD. The author suggests that there may be a genetic link between SAD and eating disorders. It is possible that there are specific inherited personality types with a predisposition to both eating disorders and SAD.
authors.affiliation: drleosher@aol.com
authors.forename: L
authors.initials: L
authors.lastname: Sher
mesh_terms: D001068:Feeding and Eating Disorders / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D016574:Seasonal Affective Disorder / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D012701:Serotonin / Q000502:physiology*; D014365:Tryptophan Hydroxylase / Q000235:genetics
chemical_list: D012701:Serotonin; D014365:Tryptophan Hydroxylase