A STR mutation in a heteropaternal twin case.
A heteropaternal male twin case with two men being alleged fathers was investigated as requested by the Court. Up to 37 PCR-based polymorphic DNA systems were studied in this case which was complicated by a paternal ACTBP2 mutation detected in one twin. This is the first report on a STR mutation in a double paternity case where both biological fathers were indisputably identified. The STR systems enable the resolution of these complex genetic relationships even in a case where a mutation in one STR locus was encountered.
Geada
H
H
Department of Legal Medicine, Faculty of Medicine, University of Lisbon, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal. hgeada@mail.telepac.pt
Ribeiro
T
T
Brito
R M
RM
Espinheira
R
R
Rolf
B
B
Hohoff
C
C
Brinkmann
B
B
D016172:DNA Fingerprinting; D005260:Female; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats; D009154:Mutation; D010334:Paternity; D020080:Tandem Repeat Sequences / Q000235:genetics*; D014429:Twins, Dizygotic / Q000235:genetics*