The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific.
We examined the effects of regional infusions of 2-amino-7-phosphonoheptanoic acid (AP7) into the substantia nigra pars reticulata (SNR) in adult male rats on flurothyl-induced clonic seizures. AP7 infusions in the SNR had dose- and region-specific effects. In the SNR(anterior), both doses of AP7 (0.1 and 5 nmol) produced an anticonvulsant effect. In the SNR(posterior), the lower dose (0.1 nmol) did not influence the seizure threshold whereas the higher dose (5 nmol) of AP7 had a proconvulsant effect. The data indicate that there are two distinct regions within the SNR which differentially respond to pharmacological manipulations of the glutamatergic system. The region-specific effects in the SNR may provide an explanation for the previous conflicting reports regarding infusions of N-methyl-D-aspartate antagonists into this structure.
Velísková
J
J
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. velisek@aecom.yu.edu
Liptáková
S
S
Hussain
S
S
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D003292:Convulsants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005481:Flurothyl / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D003292:Convulsants; D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D015763:2-Amino-5-phosphonovalerate; D005481:Flurothyl; C031231:2-amino-7-phosphonoheptanoic acid