title: Comparative HPLC enantioseparation of new chiral hydantoin derivatives on three different polysaccharide type chiral stationary phases.
abstract: The enantioseparation of eighteen new chiral hydantoin derivatives was studied on three different polysaccharide type chiral stationary phases (CSP) Chiralpak AD, Chiralcel OD and Chiralcel OJ in the normal-phase HPLC mode. Chiralpak AD material exhibited the most universal chiral resolving ability and allowed the enantioseparation of 17 out of 18 compounds followed by Chiralcel OD (10 enantioseparations of 12 tested compounds) and Chiralcel OJ (eight enantioseparation from 13 tested analytes). Some complementary separations were observed and all of 18 compounds could be resolved at least with one of the three chiral CSP under the conditions of this study. With regard to the structure of the analytes, bulky electron rich substituents at C5 of the hydantoin nucleus appear to favor stereoselective interactions.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Münster, Hittorfstrasse 58-62, 48149 Münster, Germany.
authors.forename: Irma
authors.initials: I
authors.lastname: Kartozia
authors.forename: Martial
authors.initials: M
authors.lastname: Kanyonyo
authors.forename: Thierry
authors.initials: T
authors.lastname: Happaerts
authors.forename: Didier M
authors.initials: DM
authors.lastname: Lambert
authors.forename: Gerhard K E
authors.initials: GK
authors.lastname: Scriba
authors.forename: Bezhan
authors.initials: B
authors.lastname: Chankvetadze
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006827:Hydantoins / Q000032:analysis* / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006827:Hydantoins; D011134:Polysaccharides