title: New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.
abstract: A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the beta(3)-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities.
authors.affiliation: Département de Pharmacochimie Moléculaire, UMR-CNRS 5063, UFR de Pharmacie, Université Joseph Fourier, BP 138, F-38243 Meylan cedex, France.
authors.forename: Silvère
authors.initials: S
authors.lastname: Aubriot
authors.forename: Edwige
authors.initials: E
authors.lastname: Nicolle
authors.forename: Mireille
authors.initials: M
authors.lastname: Lattier
authors.forename: Cécile
authors.initials: C
authors.lastname: Morel
authors.forename: Wenhong
authors.initials: W
authors.lastname: Cao
authors.forename: Kiefer W
authors.initials: KW
authors.lastname: Daniel
authors.forename: Sheila
authors.initials: S
authors.lastname: Collins
authors.forename: Gérard
authors.initials: G
authors.lastname: Leclerc
authors.forename: Patrice
authors.initials: P
authors.lastname: Faure
mesh_terms: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D019556:COS Cells; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011412:Propanolamines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists; D016166:Free Radical Scavengers; D011412:Propanolamines