title: Recognition of specific DNA sequences.
abstract: Proteins that recognize specific DNA sequences play a central role in the regulation of transcription. The tremendous increase in structural information on protein-DNA complexes has uncovered a remarkable structural diversity in DNA binding folds, while at the same time revealing common themes in binding to target sites in the genome.
authors.affiliation: Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: C W
authors.initials: CW
authors.lastname: Garvie
authors.forename: C
authors.initials: C
authors.lastname: Wolberger
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D001483:Base Sequence / Q000235:genetics; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D015032:Zinc / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D004247:DNA; D015032:Zinc