[Levetiracetam].
Levetiracetam is a new antiepileptic drug with a chemical structure similar to piracetam, but different pharmacological properties. The pharmacokinetic profile of levetiracetam closely approximates the ideal characteristics expected of an antiepileptic drug: good bioavailability, linear kinetics, rapid achievement of steady-state concentrations, minimal protein binding and minimal metabolism. It has been approved as add-on therapy for the treatment of partial-onset seizures in adults. Its efficacy has been proved through four pivotal double-blind, aleatorized, placebo-controlled trials. Levetiracetam is well-tolerated and the incidence of adverse events is similar to placebo. There is no evidence of any specific interactions between levetiracetam and digoxin, warfarin, probenecid or other antiepileptic drugs. Preclinical studies have shown potential efficacy against generalized seizures. Antidystonic and antimyoclonic effects have been also suggested. There are few data of its efficacy on monotherapy and pediatric population.
Salas-Puig
J
J
Servicio de Neurología II. Hospital Central de Asturias, Oviedo. jsalasp@meditex.es
Calleja
S
S
D000328:Adult; D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004347:Drug Interactions; D004828:Epilepsies, Partial / Q000188:drug therapy*; D006801:Humans; D007858:Learning / Q000187:drug effects; D000077287:Levetiracetam; D008568:Memory / Q000187:drug effects; D015394:Molecular Structure; D010889:Piracetam / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam