title: Elevated C-reactive protein constitutes an independent predictor of advanced carotid plaques in dyslipidemic subjects.
abstract: Inflammation plays a key role in the physiopathology of atherosclerosis. C-reactive protein (CRP) has been found to predict cardiac events in healthy subjects and in patients with coronary heart disease. However, the relationship between CRP and subclinical atherosclerosis is not well established. We examined the potential relationship between CRP and common carotid artery intima-media thickness and carotid plaques in dyslipidemic subjects. Dyslipidemic patients (n=1051) were recruited for the study. All patients had a complete clinical examination and systematically underwent ultrasonographic evaluation of the extracranial carotid arteries on a duplex system. The serum concentration of CRP was measured by using a sensitive immunoradiometric assay. In a univariate model, a strong positive relationship was found between CRP and the severity of carotid stenosis (P<0.0001). In multivariate analysis, the association between CRP and the degree of carotid atherosclerosis remained significant for advanced plaques (P=0.0007) in male subjects only. Significant correlations were found between CRP and body mass index (P<0.0001) and between CRP and other markers associated with the metabolic syndrome. In this large dyslipidemic population, elevated CRP is an independent predictor of advanced carotid plaques in male subjects. Body mass index and other markers of the metabolic syndrome (HDL cholesterol, triglycerides, diabetes, and high blood pressure) are significant determinants of CRP levels in this population.
authors.affiliation: Service d'Endocrinologie-Métabolisme, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Blackburn
authors.forename: P
authors.initials: P
authors.lastname: Giral
authors.forename: E
authors.initials: E
authors.lastname: Bruckert
authors.forename: J M
authors.initials: JM
authors.lastname: André
authors.forename: S
authors.initials: S
authors.lastname: Gonbert
authors.forename: M
authors.initials: M
authors.lastname: Bernard
authors.forename: M J
authors.initials: MJ
authors.lastname: Chapman
authors.forename: G
authors.initials: G
authors.lastname: Turpin
mesh_terms: D001161:Arteriosclerosis / Q000175:diagnosis* / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D016893:Carotid Stenosis / Q000175:diagnosis / Q000453:epidemiology; D016022:Case-Control Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D017678:Sex Distribution; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein