Gene mutation as a target for early detection in cancer diagnosis.
The increasing number of genetic aberrations implicated in the development of human cancer has prompted a search to detect them at the earliest possible stage of their formation. Of the many such genetic changes identified thus far, relatively few meet the standard for markers in early diagnosis and prognosis, namely that the genetic modifications occur during the early onset phase of cancer development. Parallel to the increasing number of such genes is the growing availability of technologies using more powerful and cost-efficient methods that enable mass screening for genetic alterations. The purpose of this review is to summarize the currently available genes that can serve as markers for early detection of cancers and methods that allow their detection.
Minamoto
T
T
Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Ronai
Z
Z
D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000235:genetics; D011110:Polymorphism, Genetic
D004273:DNA, Neoplasm