title: Wound healing activity of human placental extracts in rats.
abstract: OBJECTIVE
  To study wound healing activity of the human placental extract (HPE) in rats.
  
  
  METHODS
  Full thickness wounds were inflicted on depilated dorsum of Charles foster rats with 8 mm Acu-punch biopsy. The HPE was applied both at topical and im routes (2.5 mL/kg). Effects were compared on the basis of physical criteria, biochemical criteria, and histopathological study with respect to untreated control, vehicle control (1.5 % benzyl alcohol), and framycetin topical treated groups.
  
  
  RESULTS
  Significant lowering of wound size (P<0.05), wound index (P<0.05), and number of days required for complete healing (P<0.01); significant gain in tensile strength (P<0.01); appreciable increase of tissue DNA, total protein, and collagenesis were observed in HPE treated group.
  
  
  CONCLUSIONS
  Human placental extract systematically helps collagenesis leading to potent healing of wounds.
authors.affiliation: SN Pradhan Centre for Neurosciences, Dr BC Roy Postgraduate Institute of Basic Medical Sciences, Calcutta 700020, India.
authors.forename: T K
authors.initials: TK
authors.lastname: Biswas
authors.forename: B
authors.initials: B
authors.lastname: Auddy
authors.forename: N P
authors.initials: NP
authors.lastname: Bhattacharya
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: B
authors.initials: B
authors.lastname: Mukherjee
mesh_terms: D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D006801:Humans; D010924:Placental Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010924:Placental Extracts; D003094:Collagen; D004247:DNA