Capability of adriamycin and busulfan to induce adaptive response in vitro.
The capability to induce an adaptive response by low doses of busulfan (BS) or adriamycin (ADR) was studied in two kinds of mammalian cells with acquired or inherent resistance to ADR (ME18/R and V3) cultured in vitro. The results indicate the presence of an adaptive response to ADR in both kinds of used cells pretreated with a low priming dose of ADR. In the same kind of cells no adaptive response to BS after priming with a low dose of this drug was found.
Anuszewska
E L
EL
Drug Institute, Chełmska 30/34, Warsaw, Poland.
Koziorowska
J H
JH
D000222:Adaptation, Physiological; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002066:Busulfan / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D004317:Doxorubicin / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004317:Doxorubicin; D002066:Busulfan