Place- and time-dependent expression of mouse sFRP-1 during development of the cerebral neocortex.
Wnts are a family of secreted proteins involved in multiple developmental mechanisms during nervous system development, including cell proliferation, cell migration, axon guidance and specification of cell positional information. We report here the expression of sFRP-1 mRNA, encoding a putative inhibitor of Wnt, in the developing mouse neocortex during the entire period when neurons for the neocortex are born. We show that sFRP-1 mRNA expression is spatially restricted to the proliferative zones during the period, when neurons are known to be generated in large numbers for the enlarging cortical plate.
Augustine
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Brain Development Laboratory, Howard Florey Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
Gunnersen
J
J
Spirkoska
V
V
Tan
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SS
D000818:Animals; D015152:Blotting, Northern; D002455:Cell Division; D002465:Cell Movement; D020224:Expressed Sequence Tags; D006624:Hippocampus / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D019579:Neocortex / Q000196:embryology*; D009474:Neurons / Q000378:metabolism; D016548:Prosencephalon / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D000099274:Frizzled-Related Proteins
D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D012333:RNA, Messenger; D000099274:Frizzled-Related Proteins