title: Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous propionibacteria from six European cities.
abstract: Forty-five cutaneous propionibacterial isolates from six European cities were found to be highly resistant to all macrolide-lincosamide-streptogramin B antibiotics, including the ketolide telithromycin. This contrasts with previously documented phenotypes associated with 23S rRNA mutations. Sequencing of the resistance determinant showed it to be erm(X) of corynebacterial origin located on the composite transposon Tn5432.
authors.affiliation: Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. micjir@leeds.ac.uk
authors.forename: Jeremy I
authors.initials: JI
authors.lastname: Ross
authors.forename: E Anne
authors.initials: EA
authors.lastname: Eady
authors.forename: Ellen
authors.initials: E
authors.lastname: Carnegie
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Cove
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004251:DNA Transposable Elements / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005060:Europe / Q000453:epidemiology; D006801:Humans; D048628:Ketolides; D055231:Lincosamides; D018942:Macrolides; D011423:Propionibacteriaceae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D025381:Streptogramin B / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D048628:Ketolides; D055231:Lincosamides; D018942:Macrolides; D025381:Streptogramin B; C106791:telithromycin