title: [Radiotherapy of early stage Dupuytren disease. Long-term results after a median follow-up period of 10 years].
abstract: OBJECTIVE
  In early stage Dupuytren's contracture radiotherapy was applied to prevent disease progression. Long-term results and late toxicity of this treatment were evaluated in a retrospective analysis.
  
  
  METHODS
  Between 1982 and 1994, 99 patients (176 hands) received orthovoltage radiotherapy, which consisted of two courses with 5 x 3 Gy (total dose: 30 Gy, daily fractionated; 120 kV, 4 mm Al), separated by a 6 to 8-week pause. The Dupuytren's contracture was staged according to the classification of Tubiana et al. The long-term outcome was analyzed at last follow-up between July and November 1999. The median follow-up was 10 years (range 7-18 years). Late toxicity was assessed using the LENT-SOMA criteria.
  
  
  RESULTS
  In Stage N 84% and Stage N/I 67% of cases remained stable. 65% of the cases in Stage I and 83% in Stage II showed progressive nodules and cords. In case of progression we saw no complications after a second radiotherapy or salvage operation.
  
  
  CONCLUSIONS
  Radiotherapy effectively prevents disease progression for early stage Dupuytren's contracture (Stage N, N/I). Moreover, in case of disease progression despite radiotherapy salvage surgery is still feasible.
authors.affiliation: Klinik und Poliklinik für Strahlentherapie der Universität Erlangen-Nürnberg, Erlangen. boris.adamietz@strahlen.med.uni-erlangen.de
authors.forename: B
authors.initials: B
authors.lastname: Adamietz
authors.forename: L
authors.initials: L
authors.lastname: Keilholz
authors.forename: J
authors.initials: J
authors.lastname: Grünert
authors.forename: R
authors.initials: R
authors.lastname: Sauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D004387:Dupuytren Contracture / Q000175:diagnosis / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies