title: Sleep-disordered breathing and coronary artery disease: long-term prognosis.
abstract: The evidence linking sleep-disordered breathing to increased mortality and cardiovascular morbidity has been conflicting and inconclusive. We hypothesized that a potential adverse effect of disordered breathing would be more obvious in patients with established vascular disease. In a prospective cohort study 408 patients aged 70 yr or younger with verified coronary disease were followed for a median period of 5.1 yr. An apnea-hypopnea index (AHI) of > or = 10 and an oxygen desaturation index (ODI) of > or = 5 were used as the diagnostic criteria for sleep-disordered breathing. The primary end point was a composite of death, cerebrovascular events, and myocardial infarction. There was a 70% relative increase and a 10.7% absolute increase in the primary composite end point in patients with disordered breathing defined as an ODI of > or = 5 (risk ratio 1.70, 95% confidence interval [CI] 1.15-2.52, p = 0.008). Similarly, patients with an AHI of > or = 10 had a 62% relative increase and a 10.1% absolute increase in the composite endpoint (risk ratio 1.62, 95% CI 1.09-2.41, p = 0.017). An ODI of > or = 5 and an AHI of > or = 10 were both independently associated with cerebrovascular events (hazard ratio 2.62, 95% CI 1.26-5.46, p = 0.01, and hazard ratio 2.98, 95% CI 1.43-6.20, p = 0.004, respectively). We conclude that sleep-disordered breathing in patients with coronary artery disease is associated with a worse long-term prognosis and has an independent association with cerebrovascular events.
authors.affiliation: Department of Cardiology, Umeå University Hospital, Umeå, Sweden. thomas.mooe@medicin.umu.se
authors.forename: T
authors.initials: T
authors.lastname: Mooe
authors.forename: K A
authors.initials: KA
authors.lastname: Franklin
authors.forename: K
authors.initials: K
authors.lastname: Holmström
authors.forename: T
authors.initials: T
authors.lastname: Rabben
authors.forename: U
authors.initials: U
authors.lastname: Wiklund
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D016022:Case-Control Studies; D002423:Cause of Death; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000209:etiology*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000150:complications* / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D016019:Survival Analysis