Perceptual correlates of neural representations evoked by odorant enantiomers.
Spatial activation patterns within the olfactory bulb are believed to contribute to the neural representation of odorants. In this study, we attempted to predict the perceptions of odorants from their evoked patterns of neural activity in the olfactory bulb. We first describe the glomerular activation patterns evoked by pairs of odorant enantiomers based on the uptake of [(14)C]2-deoxyglucose in the olfactory bulb glomerular layer. Using a standardized data matrix enabling the systematic comparison of these spatial odorant representations, we hypothesized that the degree of similarity among these representations would predict their perceptual similarity. The two enantiomers of carvone evoked overlapping but significantly distinct regions of glomerular activity; however, the activity patterns evoked by the enantiomers of limonene and of terpinen-4-ol were not statistically different from one another. Commensurate with these data, rats spontaneously discriminated between the enantiomers of carvone, but not between the enantiomers of limonene or terpinen-4-ol, in an olfactory habituation task designed to probe differences in olfactory perception.
Linster
C
C
Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA. CL243@cornell.edu
Johnson
B A
BA
Yue
E
E
Morse
A
A
Xu
Z
Z
Hingco
E E
EE
Choi
Y
Y
Choi
M
M
Messiha
A
A
Leon
M
M
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D003847:Deoxyglucose / Q000378:metabolism / Q000493:pharmacokinetics; D004193:Discrimination Learning / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology; D000077222:Limonene; D008297:Male; D039821:Monoterpenes; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism; D010465:Perception / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012054:Reinforcement, Psychology; D012903:Smell / Q000187:drug effects / Q000502:physiology*; D013237:Stereoisomerism; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D039821:Monoterpenes; D013729:Terpenes; C034019:terpinenol-4; C006923:carvone; D003847:Deoxyglucose; D000077222:Limonene