Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma.
To investigate whether genetic differences in cytokine promoter polymorphisms effect various outcomes after exposure to Epstein-Barr virus (EBV) infection, 30 patients with EBV-positive gastric carcinoma (GC), 120 patients with EBV-negative GC, and 220 control subjects were enrolled. Promoter polymorphisms of tumor necrosis factor (TNF)-alpha at positions -238 and -308 and of interleukin (IL)-10 at position -1082 were determined. The frequency of the high-producer allele (-308A) in the TNF-alpha gene was significantly higher among EBV-positive GC patients compared with control subjects (23.3% vs. 12.0%, P<.05), whereas the frequency of the high-producer allele (-1082G) in the IL-10 gene was significantly higher among EBV-negative GC patients compared with control subjects (6.3% vs. 3.0%, P<.05). These data support the notion that genetic factors may modify the outcomes of infectious diseases through different TNF-alpha- or IL-10-producing capabilities.
Wu
Ming-Shiang
MS
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Huang
Shih-Pei
SP
Chang
Yu-Ting
YT
Shun
Chia-Tung
CT
Chang
Ming-Chu
MC
Lin
Ming-Tsan
MT
Wang
Hsiu-Po
HP
Lin
Jaw-Town
JT
D000230:Adenocarcinoma / Q000150:complications / Q000235:genetics* / Q000821:virology; D002681:China / Q000208:ethnology; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013274:Stomach Neoplasms / Q000150:complications / Q000235:genetics* / Q000821:virology; D013624:Taiwan; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10