Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments.
Del22q11 syndrome is caused by heterozygous deletion of an approximately 3 Mb segment of chromosome 22q11.2. Children diagnosed with del22q11 syndrome commonly have learning difficulties, deficits of motor development, cognitive defects and attention deficit disorder. They also have a higher than normal risk for developing psychiatric disorders, mainly schizophrenia, schizoaffective disorder and bipolar disorder. Here, we show that mice that are heterozygously deleted for a subset of the genes that are deleted in patients have deficits in sensorimotor gating and learning and memory. The finding of sensorimotor gating deficits is particularly significant because patients with schizophrenia and schizotypal personality disorder show similar deficits. Thus, our deletion mouse models at least two major features of the del22q11-associated behavioral phenotype, and as such, represents an animal model of this complex behavioral phenotype. These findings not only open the way to pharmacological analyses that may lead to improved treatments, but also to the identification of gene/s that modulate these specific behaviors in humans.
Paylor
R
R
Department of Molecular and Human Genetics, Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, 325D, Houston, TX 77030, USA.
McIlwain
K L
KL
McAninch
R
R
Nellis
A
A
Yuva-Paylor
L A
LA
Baldini
A
A
Lindsay
E A
EA
D000015:Abnormalities, Multiple / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D004062:DiGeorge Syndrome / Q000235:genetics* / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D020233:Gait Disorders, Neurologic / Q000503:physiopathology; D005838:Genotype; D006801:Humans; D007859:Learning Disabilities / Q000503:physiopathology; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D013216:Reflex, Startle / Q000502:physiology; D013577:Syndrome