Treatment of picornavirus infections.
The picornaviruses are a diverse group of viral pathogens that together comprise the most common causes of infections of humans in the developed world. Within the picornavirus family are three well-known groups of human pathogens-the enteroviruses (including polioviruses, coxsackieviruses, and echoviruses), the rhinoviruses, and the hepatoviruses (including hepatitis A). Recently, the parechoviruses (formerly, echoviruses 22 and 23) have been classified as a fourth genus of human picornaviruses. This article will focus on the enteroviruses and rhinoviruses agents, for which substantial effort has been expended and recent successes reported towards the development of safe and effective antiviral therapy.
Rotbart
Harley A
HA
Department of Pediatrics, University of Colorado School of Medicine, 4200 E. 9th Avenue, Box C227, Denver, CO 80262, USA. harley.rotbart@uchsc.edu
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D015195:Drug Design; D004770:Enterovirus / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010850:Picornaviridae Infections / Q000188:drug therapy* / Q000821:virology; D012229:Rhinovirus / Q000187:drug effects*
D000998:Antiviral Agents