title: [Neonatal renal vein thrombosis in a heterozygous carrier of both factor V Leiden and prothrombin mutations].
abstract: We report a case of renal vein thrombosis, treated with heparin and thrombolytic therapy, in a patient who was heterozygous for both factor V Leiden and prothrombin mutations.
  
  
  METHODS
  A full-term infant was treated with heparin and fibrinolytics at the fourth day of life because of renal vein thrombosis, inferior vena cava thrombosis and adrenal hemorrhage. After four days of treatment, the repermeabilization was complete but a renal atrophy developed. The investigation for congenital coagulation disorders revealed a heterozygous mutation for both factor V Leiden and prothrombin.
  
  
  CONCLUSIONS
  Search for inborn blood coagulation disorders should be systematic in the newborn infant with venous thrombosis because of the risk of recurrence, even in the presence of a known acquired risk factor. The thrombolytic treatment improves the prognosis.
authors.affiliation: Service de médecine et réanimation néonatale, maternité régionale et universitaire, 10, rue du docteur-Heydenreich, 54000 Nancy, France. nleret@ch-havre.fr
authors.forename: N
authors.initials: N
authors.lastname: Leret
authors.forename: A
authors.initials: A
authors.lastname: Cortey
authors.forename: C
authors.initials: C
authors.lastname: Maillard
authors.forename: M
authors.initials: M
authors.lastname: Rouabah
authors.forename: J M
authors.initials: JM
authors.lastname: Hascoët
authors.forename: T
authors.initials: T
authors.lastname: Lecompte
authors.forename: E
authors.initials: E
authors.lastname: de Maistre
mesh_terms: D000307:Adrenal Gland Diseases; D000925:Anticoagulants / Q000627:therapeutic use; D005165:Factor V / Q000235:genetics*; D006470:Hemorrhage; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D011516:Prothrombin / Q000235:genetics*; D012082:Renal Veins / Q000473:pathology*; D012307:Risk Factors; D015912:Thrombolytic Therapy; D014682:Vena Cava, Inferior / Q000473:pathology; D020246:Venous Thrombosis / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D006493:Heparin
vernacular_title: Thrombose veineuse rénale néonatale et double hétérozygotie pour le facteur V Leiden et la prothrombine.