Conserved cues for axon and dendrite growth in the developing cortex.
The cellular and molecular mechanisms that guide axonal and dendritic differentiation in the cerebral cortex are just beginning to be defined. Many of the molecular signals that guide axons also, and sometimes simultaneously, influence dendritic growth. Whitford et al. (2002 [this issue of Neuron]) demonstrate that in addition to their roles in axon guidance and cell migration cue, Slit proteins can also regulate dendritic growth.
McAllister
A Kimberley
AK
Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95616, USA.
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D002633:Chemotaxis / Q000502:physiology*; D003712:Dendrites / Q000378:metabolism* / Q000648:ultrastructure; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism; D040121:Semaphorin-3A; D000097905:Roundabout Proteins
D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D040121:Semaphorin-3A; D000097905:Roundabout Proteins; C108639:SEMA3A protein, human; C492289:SLIT1 protein, human; C488217:Sema3a protein, mouse