Nuclear estrogen receptor II (nER-II) is involved in the estrogen-dependent ribonucleoprotein transport in the goat uterus I. Localization of nER-II in snRNP.
Exposure of goat uterine nuclei to estradiol in vitro results in an immediate exit of ribonucleoproteins (RNP) from the nuclei to the medium. This RNP exit appears to be mediated by an estrogen receptor localized in small nuclear ribonucleoproteins containing U1 and U2 snRNA. Available evidence indicates that the estrogen receptor involved is not the ERalpha, but an alternative form, which is also a 66 kDa protein. This is the nuclear estrogen receptor II (nER-II) that has no DNA-binding capacity. The transport is estrogen-specific since non-estrogenic steroids do not stimulate the transport of the RNP where the receptor is localized.
Sebastian
Thomas
T
Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram-695014, Kerala, India.
Thampan
Raghava Varman
RV
D000818:Animals; D002846:Chromatography, Affinity; D002852:Chromatography, Ion Exchange; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006041:Goats; D008854:Microscopy, Electron; D021381:Protein Transport; D011960:Receptors, Estrogen / Q000502:physiology*; D017411:Ribonucleoproteins, Small Nuclear / Q000378:metabolism* / Q000648:ultrastructure; D014599:Uterus / Q000378:metabolism*
D004967:Estrogens; D011960:Receptors, Estrogen; D017411:Ribonucleoproteins, Small Nuclear