title: Hypersensitivity to warfarin in a patient with a mechanical aortic prosthesis.
abstract: The case of a patient with a prosthetic aortic valve and warfarin hypersensitivity is presented. On rechallenging the patient with warfarin, a spongiotic dermatitis with heavy superficial perivascular lymphocytic infiltrates with eosinophils was seen. The patient was finally discharged on aspirin therapy alone and is doing well to date. Warfarin hypersensitivity is rare, and only incidental reports exist regarding its incidence and management. It is conceivable that newer antiplatelet agents, whether alone or in combination with aspirin, will provide better control of thromboembolic events in patients with warfarin intolerance.
authors.affiliation: Department of Medicine, Scott & White Memorial Hospital and Clinic, Scott, Sherwood and Brindley Foundation, The Texas A&M University System Health Science Center College of Medicine, Temple 54449, USA.
authors.forename: T
authors.initials: T
authors.lastname: Tak
authors.forename: J F
authors.initials: JF
authors.lastname: Smith
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D003875:Drug Eruptions / Q000473:pathology*; D004342:Drug Hypersensitivity; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D014859:Warfarin