title: [Liquid phase cytology in the primary screening for cervical cancer: a multicenter study].
abstract: The aim of this six-centre, split-sample study was to compare ThinPrep fluid-based cytology to the conventional Papanicolaou smear. Six Cytopathology laboratories and 35 Gynaecologists participated. 5428 patients met the inclusion criteria. Each cervical sample was used first to prepare a conventional Pap smear, then the sampling device was rinsed into a PreservCyt vial, and a ThinPrep slide was made. Screening of slide pairs was blinded. On initial screening, 29% more ASCUS and 39% more low-grade squamous intraepithelial lesions (LSIL) and more severe lesions (LSIL+) were detected on the ThinPrep slides than on the conventional smears (p = 0.001). Independent and consensus review confirmed 145 LSIL + diagnoses; of these, 18% more had been detected initially on the ThinPrep slides than on the conventional smears (p = 0.041). The ThinPrep Pap Test is more accurate than the conventional Pap Test and has the potential to optimize the effectiveness of primary cervical cancer screening.
authors.affiliation: Institut Alfred Fournier, 25, boulevard Saint-Jacques, 75014 Paris, France. admin@eurogin.com
authors.forename: J
authors.initials: J
authors.lastname: Monsonégo
authors.forename: A
authors.initials: A
authors.lastname: Autillo-Touati
authors.forename: C
authors.initials: C
authors.lastname: Bergeron
authors.forename: R
authors.initials: R
authors.lastname: Dachez
authors.forename: J
authors.initials: J
authors.lastname: Liaras
authors.forename: J
authors.initials: J
authors.lastname: Saurel
authors.forename: L
authors.initials: L
authors.lastname: Zerat
authors.forename: P
authors.initials: P
authors.lastname: Chatelain
authors.forename: C
authors.initials: C
authors.lastname: Mottot
mesh_terms: D000328:Adult; D003581:Cytodiagnosis / Q000379:methods*; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D012680:Sensitivity and Specificity; D012996:Solutions; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears / Q000379:methods*; D002578:Uterine Cervical Dysplasia / Q000473:pathology
chemical_list: D012996:Solutions
vernacular_title: Cytologie en phase liquide dans le cadre du dépistage primaire du cancer du col utérin: une étude multicentrique.