Indium-mediated intermolecular alkyl radical addition to electron-deficient C [double bond] N bond and C [double bond] C bond in water.
[reaction: see text] The intermolecular alkyl radical addition to imine derivatives was studied in aqueous media by using indium as a single-electron-transfer radical initiator. The one-pot reaction based on radical addition to glyoxylic hydrazone provided a convenient method for preparing the alpha-amino acids. The indium-mediated radical addition to an electron-deficient C=C bond also proceeded effectively to provide the new carbon-carbon bond-forming method in aqueous media.
Miyabe
Hideto
H
Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan.
Ueda
Masafumi
M
Nishimura
Azusa
A
Naito
Takeaki
T