title: Modulation of caudal intestinal permeability in the rat during infection by the tapeworm Hymenolepis diminuta.
abstract: Bidirectional movement of solutes between the intestinal lumen and systemic circulation is restricted by tissue barriers that may be altered under conditions such as intestinal infection. In a study using an in vitro everted sac preparation to assess small intestinal permeability in a lumen-to-serosa direction, 51Cr-EDTA movement was compared regionally in the jejunum and ileum of rats infected and uninfected by tapeworms. Whereas jejunal segments showed no significant differences in permeability to 51Cr-EDTA at 6, 15, or 32 days postinfection (dpi), ileal segments displayed an increased permeability on 15 and 32 dpi, but not 6 dpi. The alterations in permeability were not reversed 1 wk after removal of the tapeworm from the intestine. In conclusion, the strictly lumen-dwelling tapeworm infection allows increased movement of molecules from the lumen into ileal, but not jejunal, tissues by 15 dpi.
authors.affiliation: Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA.
authors.forename: N P
authors.initials: NP
authors.lastname: Zimmerman
authors.forename: P
authors.initials: P
authors.lastname: Bass
authors.forename: J A
authors.initials: JA
authors.lastname: Oaks
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D001692:Biological Transport; D004068:Digestive System Physiological Phenomena; D006925:Hymenolepiasis / Q000188:drug therapy / Q000378:metabolism*; D007422:Intestines / Q000469:parasitology* / Q000502:physiology*; D008297:Male; D010539:Permeability; D011223:Praziquantel / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000871:Anthelmintics; D011223:Praziquantel