[Effect of potassium channel openers on lysosomal function and morphology during acute hypoxic hypoxia].
It was studying the effect of fluorinecontain pinacidil analogs (PF-5 and PF-10), which are the K(+)-channel openers, on morphofunctional lysosomes state at lung and heart tissues. The investigation was made on white pubertal rat-males under acute (30 min) hypoxic hypoxia (7% O2 [symbol: see text] N2). The application of PF-5 and PF-10 under acute hypoxic hypoxia leads in lung and myocardium tissues to morphofunctional changes of lysosome system in investigated cells, which were connected with decreasing of enzyemia. It, partly, may be explain by increasing of connected enzyme forms synthesis, because such forms are the functional latent, so the output of enzymes in blood under unfavourable conditions increased.
Honchar
O O
OO
A.A. Bogomoletz Instityte of Physiology, National Academy of Sciences of Ukraine, Kiev.
Rozova
K V
KV
Seredenko
M M
MM
D000135:Acid Phosphatase / Q000378:metabolism; D000208:Acute Disease; D000818:Animals; D002402:Cathepsin D / Q000378:metabolism; D004195:Disease Models, Animal; D006321:Heart / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D008168:Lung / Q000201:enzymology / Q000503:physiopathology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D020110:Pinacidil / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015221:Potassium Channels / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D015221:Potassium Channels; D020110:Pinacidil; D000135:Acid Phosphatase; D002402:Cathepsin D
Vplyv moduliatoriv aktyvnosti kaliievykh kanaliv na morfofunktsional'nyĭ stan lizosom pry hostriĭ hipoksychniĭ hipoksiï.