[Morphometrical study on the development of the trisomy-18 with cleft palate and euploid mice].
OBJECTIVE
To quantitatively compare the whole body, the lateral maxillofacial profile in Ts18 foetuses with cleft palate (Ts + CP) and euploid foetuses in order to answer the question whether this animal model is associated with maldevelopment or hypoplasia of the craniomaxillofacial region.


METHODS
Sixty female Hanmice and 11 male mice with the Rb(2.18) 6Rma and Rb(1.18) 10Rma chromosomes were used to generate 569 living foetuses. Of these, 52 pairs Ts + CP and euploid foetuses were selected according to about equal body weight, and used in gross morphometric study.


RESULTS
Ts + 18 foetuses had greater body flexion, a significant maxillary and mandibular retrusion, also mandible in Ts + CP foetuses were smaller than in euploids without cleft.


CONCLUSIONS
This animal model of congenital cleft palate developed hypoplasia of the maxilla and mandible.
Cai
Z
Z
Department of Oral and Maxillofacial Surgery, School of Stomatology, Bejing Medical University, Beijing 100081, China.
von Domarus
H
H
Engel
E
E
D000818:Animals; D002875:Chromosomes; D002972:Cleft Palate / Q000235:genetics / Q000473:pathology*; D000013:Congenital Abnormalities / Q000235:genetics / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D011247:Pregnancy; D014314:Trisomy