title: Update on the development and use of viral and bacterial vaccines for the prevention of acute otitis media.
abstract: Acute otitis media (AOM) is the most frequent diagnosis in physician offices among children 1-4 years of age. Viruses that cause upper respiratory tract infections (i.e., respiratory syncytial virus [RSV], influenza virus, parainfluenza virus [PIV], and others) play an important role in the development of AOM. Prevention of infections with these viral pathogens likely would reduce the incidence of AOM. In three previous studies, influenza virus vaccines showed 30-36% efficacy against the development of AOM. Vaccines to prevent infections with RSV and PIV type 3 are undergoing clinical testing at this time. The three major bacterial pathogens causing AOM are Streptococcus pneumoniae, nontypeable Haemophilus influenzae (NTHi), and Moraxella catarrhalis. Pneumococcal conjugate vaccine, licensed in the United States in 2000, was shown in two pivotal trials to reduce the incidence of all causes of AOM by 6%, pneumococcal AOM by 34%, and pneumococcal AOM caused by serotypes contained in the vaccine by 57%. Currently, vaccines against NTHi and M. catarrhalis are under development.
authors.affiliation: Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Greenberg
mesh_terms: D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation; D001428:Bacterial Vaccines / Q000276:immunology*; D002669:Child Welfare; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007229:Infant Welfare; D007252:Influenza Vaccines / Q000276:immunology; D010033:Otitis Media / Q000150:complications / Q000276:immunology* / Q000517:prevention & control*; D012141:Respiratory Tract Infections / Q000150:complications / Q000276:immunology / Q000517:prevention & control; D012307:Risk Factors; D013210:Staphylococcus / Q000276:immunology*; D013291:Streptococcus / Q000276:immunology*; D014481:United States / Q000453:epidemiology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D007252:Influenza Vaccines; D014765:Viral Vaccines