title: [The role of hyperlactatedehydrogenasemia in induction of metabolic disorders in the body].
abstract: The effect of intravenous administration of lactate dehydrogenase (5000 E/kg) on some metabolic parameters was investigated. The hyperenzymemia was accompanied by changes of metabolite content (glutamate, 2-oxoglutarate, lactate, dihydroxyacetone phosphate) and enzyme activities (aldolase, lactate dehydrogenase, transaminase) in heart, liver and skeletal muscles. Intravenously administered tritiated lactate dehydrogenase was preferentially found in skeletal muscles, liver, kidneys and some other organs.
authors.affiliation: Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostic of Samara State Medical University.
authors.forename: F N
authors.initials: FN
authors.lastname: Gil'miiarova
authors.forename: V M
authors.initials: VM
authors.lastname: Radomskaia
authors.forename: G M
authors.initials: GM
authors.lastname: Baisheva
authors.forename: I G
authors.initials: IG
authors.lastname: Kretova
authors.forename: M S
authors.initials: MS
authors.lastname: Kleĭman
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Pervova
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D006019:Glycolysis; D007668:Kidney / Q000201:enzymology / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D009928:Organ Specificity; D010084:Oxidation-Reduction; D011817:Rabbits; D013154:Spleen / Q000201:enzymology / Q000378:metabolism; D014316:Tritium
chemical_list: D014316:Tritium; D007770:L-Lactate Dehydrogenase
vernacular_title: Rol' giperlaktatdegidrogenazemii v induktsii metabolicheskikh narusheniĭ v organizme.