[Prevention and treatment of recurrent urinary system infection with estrogen cream in postmenopausal women].
OBJECTIVE
To evaluate the effect and feasibility of using estrogen cream for the prevention and treatment of recurrent urinary tract infection (UTI) in postmenopausal women.


METHODS
Forty-five postmenopausal women with a history of recurrent UTI were divided into two groups (group premarin and group antibiotic). Participants were assigned to apply intravaginal premarin cream (group premarin, n = 30) or oral antibiotic (group antibiotic, n = 15) for 3 months respectively. Urine routine test, midstream urine and vaginal cultures, vaginal health score (VHS), vaginal cell maturation value (MV), endometrial thickness and blood estrogen level were obtained before and after the study.


RESULTS
The incidence of UTI in the group premarin was significantly reduced as compared with that in the group antibiotic (2/27 vs. 12/15, P < 0.001). In the group premarin Lactobacilli reappeared (from 0 to 59.3%) and MV (from 9.2 +/- 6.8 to 74.6 +/- 14.1) and VHS (from 5.2 +/- 0.4 to 13.4 +/- 2.5) were improved after 3 months. There was no significant change in the group antibiotic.


CONCLUSIONS
It seems that intravaginal use of estrogen cream would effectively prevent and reduce the UTI in postmenopausal women.
Xu
R
R
Department of Obstetrics and Gynecology, Beijing Hospital, Ministry of Public Health, Beijing 100730, China.
Wu
Y
Y
Hu
Y
Y
D000368:Aged; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D055502:Secondary Prevention; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000517:prevention & control*; D014622:Vaginal Creams, Foams, and Jellies
D004966:Estrogens, Conjugated (USP); D014622:Vaginal Creams, Foams, and Jellies