Inflammatory bowel disease.
This article reviews a selection of 50 papers on inflammatory bowel disease published between April 2000 and June 2001. The new information summarized here includes: the discovery of the association of the NOD2 gene with Crohn's disease; the role of bacteria and the modulating effects of probiotics; the inverse association of appendectomy and ulcerative colitis; progress in imaging based on magnetic resonance imaging and leukocyte scintigraphy; assessment of the value of anti-Saccharomyces cerevisiae antibodies in the screening of inflammatory bowel disease and differentiation between ulcerative colitis and Crohn's disease; and risk factors and management of dysplasia and cancer. This article does not review all therapeutic aspects, but focuses on smoking cessation; anti-tumor necrosis factor antibody treatments; the usefulness of measuring erythrocyte 6-thioguanine metabolite levels to optimize purine analogue therapy; strictureplasty; and the long-term results of ileoanal anastomosis.
Marteau
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Department of Gastroenterology, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, and Paris V University, France. philippe.marteau@egp.ap-hop-paris.fr
D000714:Anastomosis, Surgical; D002352:Carrier Proteins; D002648:Child; D003106:Colon / Q000601:surgery; D015179:Colorectal Neoplasms / Q000209:etiology; D003424:Crohn Disease / Q000188:drug therapy; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D047908:Intracellular Signaling Peptides and Proteins; D010535:Laparoscopy; D008457:Measles / Q000150:complications; D053473:Nod2 Signaling Adaptor Protein; D011506:Proteins / Q000235:genetics; D012007:Rectum / Q000601:surgery; D012307:Risk Factors; D016540:Smoking Cessation
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D011506:Proteins