Evaluation of polypeptide growth factors in the process of dental implant osseointegration.
The aim of the present study was to evaluate the concentration of three polypeptide growth factors: transforming growth factor beta (TGF beta), platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) in the blood of patients treated with Italian Logos system implants. The blood for analysis was collected three times: prior to the surgery, the day after and four months after the procedure before implant exposure for the prosthetic phase. The concentration of growth factors was assayed using ELISA method with R&D kits. The mean serum PDGF concentration on the first day and after 4 months following the procedure were comparable to the preliminary examination. The mean serum concentration of TGF beta in the second examination increased significantly compared to that before surgery. Four months later its mean concentration was lower than in the second examination, but still higher than in the preliminary examination. The mean serum FGF concentration in our patients remained similar throughout the study. Based on presented above data we conclude that inflammation process caused by tissue injure during implantation stimulates TGF beta release what can be detected by increase of it's concentration in blood serum.
Pietruski
J K
JK
Department of Prosthodontics, Medical Academy of Białystok, Białystok, Poland.
Pietruska
M D
MD
Stokowska
W
W
Pattarelli
G M
GM
D000328:Adult; D015921:Dental Implants; D005346:Fibroblast Growth Factors / Q000097:blood; D006133:Growth Substances / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000097:blood
D015921:Dental Implants; D006133:Growth Substances; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors