title: Single-nucleotide polymorphisms of the proprotein convertase subtilisin/ kexin type 5 (PCSK5) gene.
abstract: The proprotein convertase. subtilisin/kexin type 5, or PCSK5, mediates post-translational endoproteolytic processing for several integrin alpha subunits. We identified two silent single-nucleotide polymorphisms (SNPs) in PCSK5, which were found to vary in frequency across ethnic groups. The identification of these amplification primers and SNPs provides tools to investigate PCSK5 for association with inflammatory or vascular phenotypes.
authors.affiliation: Blackburn Cardiovascular Genetics Laboratory, John P. Robarts Research Institute, London, ON, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Cao
authors.forename: A
authors.initials: A
authors.lastname: Mok
authors.forename: B
authors.initials: B
authors.lastname: Miskie
authors.forename: R A
authors.initials: RA
authors.lastname: Hegele
mesh_terms: D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D043484:Proprotein Convertases; D029701:Saccharomyces cerevisiae Proteins; D013381:Subtilisins / Q000235:genetics*
chemical_list: D017931:DNA Primers; D029701:Saccharomyces cerevisiae Proteins; D043484:Proprotein Convertases; D013381:Subtilisins; C058751:KEX2 protein, S cerevisiae