title: [A generalized chemical-kinetic method for modeling gene networks].
abstract: Development of methods for mathematical simulation of biological systems and building specific simulations is an important trend of bioinformatics development. Here we describe the method of generalized chemokinetic simulation generating flexible and adequate simulations of various biological systems. Adequate simulations of complex nonlinear gene networks--control system of cholesterol by synthesis in the cell and erythrocyte differentiation and maturation--are given as the examples. The simulations were expressed in terms of unit processes--biochemical reactions. Optimal sets of parameters were determined and the systems were numerically simulated under various conditions. The simulations allow us to study possible functional conditions of these gene networks, calculate consequences of mutations, and define optimal strategies for their correction including therapeutic ones. Graphical user interface for these simulations is available at http://wwwmgs.bionet.nsc.ru/systems/MGL/GeneNet/.
authors.affiliation: likho@bionet.nsc.ru
authors.forename: V A
authors.initials: VA
authors.lastname: Likhoshvaĭ
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Matushkin
authors.forename: A V
authors.initials: AV
authors.lastname: Ratushnyĭ
authors.forename: E A
authors.initials: EA
authors.lastname: Anan'ko
authors.forename: E V
authors.initials: EV
authors.lastname: Ignat'eva
authors.forename: O A
authors.initials: OA
authors.lastname: Podkolodnaia
mesh_terms: D000465:Algorithms; D002784:Cholesterol / Q000096:biosynthesis; D003196:Computer Graphics; D004171:Diploidy; D004912:Erythrocytes / Q000378:metabolism; D006238:Haploidy; D020407:Internet; D007700:Kinetics; D008957:Models, Genetic
chemical_list: D002784:Cholesterol
vernacular_title: Obobshchennyĭ khimiko-kineticheskiĭ metod modelirovaniia gennykh seteĭ.