title: The proline form of p53 codon 72 polymorphism is associated with endometriosis.
abstract: OBJECTIVE
  To evaluate the association between endometriosis and the p53 polymorphism.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Department of gynecology and genetics in a medical center.
  
  
  METHODS
  Women with and without endometriosis.
  
  
  METHODS
  Women were categorized as having moderate or severe endometriosis (n = 118) or no endometriosis (n = 140).
  
  
  METHODS
  Polymerase chain reaction was used to detect p53 codon 72 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity). Associations between endometriosis and p53 polymorphisms were evaluated.
  
  
  RESULTS
  The distributions of different p53 polymorphisms differed significantly between groups. The respective proportions of arginine homozygotes, heterozygotes, and proline homozygotes were 10.2%, 66.9%, and 22.9% in the group with endometriosis and 30.7%, 50%, and 19.3% in the group without endometriosis.
  
  
  CONCLUSIONS
  Endometriosis is associated with p53 polymorphism. p53 arginine homozygotes have lower risk for endometriosis. Heterozygotes and proline homozygotes have higher risk for endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan.
authors.forename: Chi Chen
authors.initials: CC
authors.lastname: Chang
authors.forename: Yao Yuan
authors.initials: YY
authors.lastname: Hsieh
authors.forename: Fuu Jen
authors.initials: FJ
authors.lastname: Tsai
authors.forename: Chang Hai
authors.initials: CH
authors.lastname: Tsai
authors.forename: Horng Der
authors.initials: HD
authors.lastname: Tsai
authors.forename: Cheng Chieh
authors.initials: CC
authors.lastname: Lin
mesh_terms: D019943:Amino Acid Substitution; D044466:Asian People; D003062:Codon / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics* / Q000601:surgery; D005260:Female; D016158:Genes, p53; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011392:Proline; D012016:Reference Values; D013624:Taiwan; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53; D011392:Proline