3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents.
This work reports the synthesis and the antiviral activities of 3-benzamido, 3-phenylureido and 3-phenylthioureido derivatives in the imidazo[1,2-a]pyridine series. The structure was proven by NMR spectroscopy. The synthesized compounds were evaluated against a large number of viruses. The 3-phenylthioureido derivative 7 showed moderate activity against human cytomegalovirus (HCMV) in vitro. The crystallographic data for 8 are also reported and explain the absence of activity against human immunodeficiency virus (HIV).
Chaouni-Enabdallah
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A
EA Groupe de Recherche en Chimie Hétérocyclique et Thérapeutique, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Tours, France.
Galtier
C
C
Allouchi
H
H
Kherbeche
A
A
Chavignon
O
O
Teulade
J C
JC
Witvrouw
M
M
Pannecouque
C
C
Snoeck
R
R
Andrei
G
G
Balzarini
J
J
De Clercq
E
E
Fauvelle
F
F
Enguehard
C
C
Gueiffier
A
A
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured; D018360:Crystallography, X-Ray; D003587:Cytomegalovirus / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010671:Phenylurea Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D010948:Viral Plaque Assay
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D007093:Imidazoles; D010671:Phenylurea Compounds; D013890:Thiourea