[Clinical study on relationship of blood stasis syndrome with plasma endothelin and nitric oxide changes in acute pancreatitis patients].
OBJECTIVE
To study the relationship of blood stasis Syndrome with plasma endothelin (ET) and nitric oxide (NO) in acute pancreatitis patients.


METHODS
A healthy control group and three groups of patients with three different Syndromes of TCM were established. Patients' ET and NO were determined by radioimmunoassay and reversed-phase high performance liquid chromatography respectively before and after treatment. The NO level was represented by the sum of NO2 and NO3.


RESULTS
ET and ET/NO ratio were not changed significantly in patients with Liver-Spleen Qi Stagnant Syndrome, but increased significantly in patients with Liver-Spleen Damp-Heat Syndrome or with Spleen Stomach excessive Heat Syndrome (P < 0.05 or P < 0.01).


CONCLUSIONS
ET and ET/NO ratio might be the important objective markers of the existence of blood stasis Syndrome in acute pancreatitis patients.
Wu
G
G
Department of TCM, First Affiliated Hospital of West China University of Medical Sciences, Chengdu (610041).
Zou
C
C
Mao
B
B
D000208:Acute Disease; D000328:Adult; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D010195:Pancreatitis / Q000097:blood* / Q000188:drug therapy
D004365:Drugs, Chinese Herbal; D016232:Endothelins; D009569:Nitric Oxide