title: Utilization of lipid-lowering drugs in men and women. a reflection of the research evidence?
abstract: This study analyzes the utilization of statin lipid-lowering drugs in a Canadian province using a population-wide drug prescription database. The utilization pattern is compared to the results of a systematic review of randomized controlled trials on their effectiveness. The study found that 74.7% of individuals prescribed a statin had no reported history of coronary heart disease (CHD). Women without CHD formed 23.1% of statins recipients; 32.9% of individuals filling a statin prescription were age 70 and over. Only 15.3% of men with CHD had been prescribed a statin. Based on the systematic review, 88.7% of the utilization of statins in this Canadian province was not supported by the results of the systematic review. Considering baseline lipid-levels does not substantially alter these findings. This study concludes that statins prescribing practices need to be realigned with research evidence. This implies refocusing utilization away from women and the elderly, towards men with CHD.
authors.affiliation: BC Office of Health Technology Assessment, Department of Health Care and Epidemiology, University of British Columbia, #429-2194 Health Sciences Mall, V6T 1Z3, Vancouver BC, Canada. isavoie@chspr.ubc.ca
authors.forename: Isabelle
authors.initials: I
authors.lastname: Savoie
authors.forename: Arminée
authors.initials: A
authors.lastname: Kazanjian
mesh_terms: D017677:Age Distribution; D000368:Aged; D000924:Anticholesteremic Agents; D001955:British Columbia / Q000453:epidemiology; D003327:Coronary Disease / Q000453:epidemiology / Q000517:prevention & control; D017723:Drug Utilization Review / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D017891:Pharmacoepidemiology; D017678:Sex Distribution
chemical_list: D000924:Anticholesteremic Agents