[Prophylactic efficacy of aerosol preparations based on Abies siberica polyprenols in experimental influenza infection].
Preliminary investigations showed high preventive activity of two of three aerosol preparations of Abies sibirica polyprenols with nonionic surface active substances towards influenza infection. At least 2 aerosol administrations are needed to attain a high protective effect, the second dose depending on the first. Relationship between animal reaction to influenza virus infection changed in a nonmonotonous mode, depending on the drug dose injected during the first treatment: as the dose increased, the death rate first decreased and reached the minimum and then increased again. Such a reaction to aerosol treatment can be explained by the hypothesis of hyperstimulation followed by exhaustion of the host defense systems after high doses of the preparation.
Sergeev
A N
AN
Safatov
A S
AS
P'iankov
O V
OV
Bulychev
L E
LE
Zhukov
V A
VA
Alekseeva
A G
AG
Petrishchenko
V A
VA
Shishkina
L N
LN
Poryvaev
V D
VD
Glotov
A G
AG
D000336:Aerosols; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D045782:Hemiterpenes; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D000439:Pentanols / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D028201:Pinaceae / Q000737:chemistry*
D000336:Aerosols; D000998:Antiviral Agents; D045782:Hemiterpenes; D000439:Pentanols; C009034:prenol
Profilakticheskaia éffektivnost' aérozoleĭ preparatov na osnove poliprenolov pikhty sibirskoĭ pri éksperimental'noĭ grippoznoĭ infektsii.