title: Effects of head and neck radiation therapy on vocal function.
abstract: OBJECTIVE
  Radiotherapy (RT) is used to treat a variety of head and neck malignancies. The larynx may receive high radiation doses even in the absence of disease. The effects of RT on the nondiseased larynx are unknown. This study will evaluate subjective and objective parameters of vocal function in patients treated with RT for nonlaryngeal malignancies.
  
  
  METHODS
  Cross-sectional observational study.
  
  
  METHODS
  Videostroboscopic, aerodynamic, and acoustic analyses were performed. Results were compared to age- and gender-matched controls. Self-assessment of voice quality was measured using the Voice Handicap Index.
  
  
  RESULTS
  A majority of patients demonstrated increased supraglottal activity (i.e., ventricular fold constriction) during stroboscopic evaluation. Significant differences compared to normative data were found in many aerodynamic and acoustic parameters. A substantial proportion (27%) of patients reported significant voice handicap. Younger patients reported greater handicap, and voice quality was worse with time.
  
  
  CONCLUSIONS
  Significant objective and subjective changes in vocal function occur in patients radiated for nonlaryngeal head and neck malignancies. Young patients may have the worst impact, and vocal dysfunction may increase with time. A prospective study of this patient population should include a baseline voice quality assessment.
authors.affiliation: Department of Otolaryngology, London Health Sciences Centre, University of Western Ontario.
authors.forename: K
authors.initials: K
authors.lastname: Fung
authors.forename: J
authors.initials: J
authors.lastname: Yoo
authors.forename: H A
authors.initials: HA
authors.lastname: Leeper
authors.forename: B
authors.initials: B
authors.lastname: Bogue
authors.forename: S
authors.initials: S
authors.lastname: Hawkins
authors.forename: J A
authors.initials: JA
authors.lastname: Hammond
authors.forename: J A
authors.initials: JA
authors.lastname: Gilchrist
authors.forename: V M
authors.initials: VM
authors.lastname: Venkatesan
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D007830:Larynx / Q000503:physiopathology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors; D014832:Voice Disorders / Q000209:etiology* / Q000503:physiopathology; D014833:Voice Quality