The role of deoxycytidine kinase in gemcitabine cytotoxicity.
van der Wilt
C L
CL
Department Oncology, University Hospital, VU Amsterdam, The Netherlands.
Kroep
J R
JR
Bergman
A M
AM
Loves
W J
WJ
Alvarez
E
E
Talianidis
I
I
Eriksson
S
S
van Groeningen
C J
CJ
Pinedo
H M
HM
Peters
G J
GJ
D000964:Antimetabolites, Antineoplastic / Q000633:toxicity*; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000473:pathology; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000633:toxicity*; D003842:Deoxycytidine Kinase / Q000235:genetics / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D015870:Gene Expression; D005938:Glucocorticoids / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D012333:RNA, Messenger / Q000378:metabolism; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*; D019311:Staurosporine / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D020298:U937 Cells; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D018931:Antineoplastic Agents, Hormonal; D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D012333:RNA, Messenger; D003841:Deoxycytidine; D003907:Dexamethasone; D012264:Ribonucleotide Reductases; D003842:Deoxycytidine Kinase; D011493:Protein Kinase C; D019311:Staurosporine; D000093542:Gemcitabine