Chinese-made electrolytic detachable coil in the embolization of a dog aneurysmal model.
OBJECTIVE
To develop a Chinese-made electrolytic detachable coil (CEDC) that would allow patients to enjoy the benefit of electrolytic detachable coil without having to rely on the expensive Guglielmi detachable coil (GDC), and to test the safety and efficiency of CEDC.


METHODS
Radiopacity of the marker of the CEDC was tested. The anti-strain force of coils and connection points were measured. In vitro and in vivo electrolyses were conducted. We produced 21 aneurysm models including lateral, bifurcation, and terminal aneurysm models, and embolized 18 models with CEDC.


RESULTS
Radiopacity of the marker was satisfactory. Anti-strain of the coil and the connection point have shown the safety and efficiency of CEDC. Electrolysis in vitro and vivo, was similar to that of GDC. 83% of the aneurysm models were completely occluded. Coils were found to induce thrombosis in the aneurysm cavity, and could lead to a new endothelium over the entrance of the aneurysm, with organized tissue replacing thrombosis in 2 months.


CONCLUSIONS
CEDC is as efficient and safe as GDC. The marker, the ability to induce thrombosis inside the sac and the growth of new endothelium over the orifice are very satisfactory.
Yang
X
X
Beijing Neurosurgical Institute, Beijing 100050, China.
Wu
Z
Z
Wang
C
C
Li
Y
Y
Liu
Z
Z
Tang
J
J
Sun
Y
Y
Zhang
Y
Y
Yin
K
K
D000818:Animals; D004285:Dogs; D004572:Electrolysis; D004621:Embolization, Therapeutic; D005260:Female; D002532:Intracranial Aneurysm / Q000628:therapy*; D008297:Male