title: [Pedigree analysis in evaluating gene frequency in aboriginal populations of Siberia].
abstract: Procedure is described to estimate allele frequencies in indigenous populations of Siberia using phenotype data not only for "pure-blood" representatives of the ethnic groups examined, but also for the descendants of mixed marriages. Implementation of the method requires reconstruction of the data on relatives for the sample examined. Inclusion of the data on descendants of mixed marriages into the analysis increases the sample information content and decreases variance of the estimates obtained. The advantages of the method are illustrated using an example of Tundra Nentsy, for whom it was shown that variance of estimates at the analysis of the blood groups allele frequencies can be diminished approximately by a factor of 1.5.
authors.affiliation: Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia. aks@bionet.nsc.ru
authors.forename: T I
authors.initials: TI
authors.lastname: Aksenovich
authors.forename: I V
authors.initials: IV
authors.lastname: Zorkol'tseva
authors.forename: A V
authors.initials: AV
authors.lastname: Kirichenko
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Aul'chenko
authors.forename: L P
authors.initials: LP
authors.lastname: Osipova
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D006801:Humans; D010375:Pedigree; D044469:Racial Groups; D012800:Siberia
vernacular_title: Analiz rodoslovnykh pri otsenke chastot alleleĭ v populiatsiiakh korennykh zhiteleĭ Sibiri.