[Local expresion of proinflammatory cytokines in maxillofacial gunshot wound].
OBJECTIVE
To study the relationship between proinflammentory cytokines and wound healing in local area.


METHODS
Interleukin(IL)-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha) expression in local soft tissues after lower jaw gunshot wound were assessed by using immunohisto-chemistry, and pathological methods.


RESULTS
High expressions of these cytokines were observed in local soft tissues of wounds after the gunshot. The cytokines expressions were different between the area near the bullet path and that far from the path. There was only one peak of the cytokines concentrations in the area far from the bullet path, while there were two peaks of the cytokines concentrations in the area near the bullet path, specially IL-6, IL-8. There were time differences for some different cytokines to reach the peaks of the their concentrations. In wound situ, the fibroblasts, mononuclear phagocytes and endothelial cells expressed IL-6, IL-8 and TNF-alpha after the firearm.


CONCLUSIONS
These results suggest that proinflammatory cytokines play an important role in regulating inflammatory cytokine reactions of local injury tissues. They might improve the functions of fibroblasts, mononuclear phagocytes and endothelial cells and stimulate wound cells to produce and release other cytokines.
Wu
Y
Y
Department of Stomatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003.
Zhou
S
S
Yang
K
K
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D004285:Dogs; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000096:biosynthesis; D008446:Maxillofacial Injuries / Q000209:etiology / Q000378:metabolism*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014948:Wounds, Gunshot / Q000150:complications / Q000378:metabolism*
D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha