[The effects of EGF, TGF-beta and insulin on the growth of rabbit's skeletal muscle satellite cell].
OBJECTIVE
To investigate the effects of epithelium growth factor (EGF), transforming growth factor-beta(TGF-beta) and insulin on the growth of cultured rabbit's skeletal muscle satellite cells.


METHODS
After treatment with EGF, TGF-beta and insulin, MTT method was used to study the proliferation of the cells.


RESULTS
EGF and insulin could promote the growth of the satellite cells more significantly than that of TGF-beta.


CONCLUSIONS
It implied that there was a close relationship between the effects of three agents and the regeneration of injured muscles. This kind of positive effect appeared in a dose- and time-dependent manner.
Xu
P
P
Department of Oral Maxillofacial Surgery, College of Stomatology, Fourth Military Medical University, Xi'an 710032, China.
Gu
X
X
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000166:cytology / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D007328:Insulin; D016212:Transforming Growth Factor beta; D004815:Epidermal Growth Factor