[Immuno-genetic significance in sensorineural hearing loss (SNHL) in the light of our own investigations].
The immunogenetic analysis in 152 patients with sensorineural hearing loss (SNHL) was studied. HLA class I antigens and haplotypes were calculated on the basis of typical linkage between HLA-A, -B, and C loci. Soluble form of HLA antigens (sHLA-I) in blood serum in a semiquantitative microabsorption test according to McLean et al. were also determined. It was found that the frequency of HLA-A2, -A25(10), -B39(16), -Cw5, and -Cw7 were different in patients with SNHL in compared to the control group (n = 1554). This deference's were highly significant, especially for HLA-Cw7 antigens (chi 2 = 88.88; p < 0.0000...1). The frequency of haplotype HLA-A25-B18-Cw7 in patients was also different (f = 362 x 10(4) vs 51 x 10(4)), and highly significant compared to the healthy individuals (n = 1944) (chi 2 = 27.37; p < 0.0000...1). Among 23 typed HLA class I antigens, significantly higher mean level was observed for 14 sHLA antigens then in control group (n = 248). The levels of sHLA-I antigens in patients sera may suggests participation of sHLA molecules in etiopathogenesis of SNHL. This hypothesis may indicate the existence of autoimmunogenetic background of SNHL within high concentrations of certain sHLA-I antigens.
Kedzierska
A
A
Samodzielna Pracownia Immunologii Klinicznej, Wydział Lekarski Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Flasza
J
J
Turowski
G
G
Reroń
E
E
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006319:Hearing Loss, Sensorineural / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008297:Male; D010641:Phenotype
D006680:HLA Antigens
Immunogenetyczne uwarunkowania w głuchocie odbiorczej (SNHL) w świetle wyników badań własnych.