[Experimental study on apoptosis induced by ursolic acid isolated from asparagus in HL-60 cells].
OBJECTIVE
To study the inhibitory effect of ursolic acid isolated from Asparagus on the proliferation of HL-60 cells.


METHODS
Effects of ursolic acid on the growth and apoptosis were evaluated by MTT assay, DNA gel electrophoresis and morphology observation respectively.


RESULTS
The IC50 value of ursolic acid for HL-60 cells was found to be 8.26 mumol/L and 10-50 mumol/L of ursolic acid could induce apoptosis of HL-60 cells expressed to ursolic acid for 1 day.


CONCLUSIONS
Ursolic acid can markedly inhibit HL-60 cells as well as induction of cells apoptosis.
Huang
J
J
Cancer Hospital and Institute, Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing (100021).
Sun
Y
Y
Lu
S
S
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D018922:HL-60 Cells / Q000473:pathology; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D000097245:Ursolic Acid
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; D000097245:Ursolic Acid