The influence of Ringer's lactate and gelatin infusion on the internal fluid balance of healthy volunteers measured by a non-invasive conductivity technique.
Eight healthy male volunteers received in random order at an interval of 1 week 2 litres of Ringer's lactate or 0.8 litre of gelatin (Gelofusine) over half an hour, after overnight fasting. At the end of the infusion period, blood volume and mean arterial pressure had increased significantly in both groups but the increase in blood volume was more pronounced with the colloid. Extracellular fluid volume increased significantly after Ringer's lactate, while a significant decrease was noticed after gelatin. A small decrease in intracellular fluid volume was noted after infusion of Gelofusine, whereas it did not change after infusion of Ringer's lactate. During the 30 min after infusion, blood volume decreased significantly after both treatments but after the colloid it remained higher than the initial value. During the post-infusion period, no significant changes in either intra- or extracellular volume were seen after either treatments. At the end of the study, urine production was significantly more after the Ringer's lactate. It can be concluded that infusion of 0.8 litre of gelatin results in a larger and longer lasting increase in blood volume than 2 litres of Ringer's lactate, probably due to mobilization of extracellular fluid volume. It also leads to extracellular fluid accumulation. The decrease in blood volume after infusion is caused by increased urine production, since no changes were seen in intra- and extracellular fluid volume during this period.
Olthof
C G
CG
Department of Anaesthesiology, Free University Hospital, PO Box 7057, 1007 MB Amsterdam, The Netherlands.
de Vries
J P
JP
de Vries
P M
PM
Kouw
P M
PM
Donker
A J
AJ
de Lange
J J
JJ
D000328:Adult; D000465:Algorithms; D017097:Electric Impedance; D005440:Fluid Therapy; D005780:Gelatin / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007552:Isotonic Solutions / Q000494:pharmacology*; D008297:Male; D009994:Osmolar Concentration; D000077325:Ringer's Lactate; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D005780:Gelatin