title: Is conservative treatment for adenocarcinoma in situ of the cervix safe?
abstract: OBJECTIVE
  To determine the long term results of treatment of adenocarcinoma in situ by conisation of the cervix using survival analysis.
  
  
  METHODS
  A retrospective study in six teaching hospitals in North West Thames.
  
  
  METHODS
  Eighty-five women with a histological diagnosis of adenocarcinoma in situ of the cervix in punch or cone biopsy were identified from pathology and clinical databases.
  
  
  RESULTS
  In one patient a small focus of adenocarcinoma in situ was found in a cervical polyp. Subsequent cytology was normal and no further treatment was undertaken. The 84 remaining women underwent diathermy loop, cold knife cone biopsy, laser cone biopsy, or needle excision of the transformation zone. A hysterectomy or second conisation was performed in 31/84 women (36.9%) as part of the initial treatment. In all, nine (10.6%) had early invasive lesions of which four were squamous. Fifty-nine patients were treated conservatively following one or two conisations (median follow up 78 weeks, range 0-543 weeks). One had a subsequent hysterectomy for menorrhagia. Five women have undergone treatment for suspected recurrence, a 21.5% cumulative rate of further treatment by four years. The cumulative rate of histologically proven recurrence after conservative management was 4.3% at one year and 15% at four years.
  
  
  CONCLUSIONS
  In those cases with clear margins in the cone biopsy, there is a place for conservative management of a selected group of patients who wish to preserve fertility. However, 16.7% of these will require further treatment after four years because of recurrent cytological abnormalities. Women who opt for conservative management should undergo regular, long term surveillance in a colposcopy clinic. Among those women with involved margins in the initial cone biopsy, there is a high incidence of residual disease. A second cone biopsy may be appropriate 'definitive treatment' for young women who wish to preserve their fertility if the margins of the second biopsy are clear and there is no evidence of invasion. Even among those for whom a hysterectomy is the proposed 'definitive treatment', a second cone biopsy may be required before hysterectomy to avoid inappropriate treatment of an occult invasive lesion.
authors.affiliation: Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK.
authors.forename: W P
authors.initials: WP
authors.lastname: Soutter
authors.forename: D
authors.initials: D
authors.lastname: Haidopoulos
authors.forename: R J
authors.initials: RJ
authors.lastname: Gornall
authors.forename: G A
authors.initials: GA
authors.lastname: McIndoe
authors.forename: J
authors.initials: J
authors.lastname: Fox
authors.forename: W P
authors.initials: WP
authors.lastname: Mason
authors.forename: A
authors.initials: A
authors.lastname: Flanagan
authors.forename: N
authors.initials: N
authors.lastname: Nicholas
authors.forename: F
authors.initials: F
authors.lastname: Barker
authors.forename: J
authors.initials: J
authors.lastname: Abrahams
authors.forename: I
authors.initials: I
authors.lastname: Lampert
authors.forename: P
authors.initials: P
authors.lastname: Sarhanis
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods; D002278:Carcinoma in Situ / Q000601:surgery*; D003127:Colposcopy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D053685:Laser Therapy / Q000379:methods; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D012189:Retrospective Studies; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000628:therapy