Expression of CSF-1 and its receptor CSF-1R in non-hematopoietic neoplasms.
CSF-1 and its receptor appear to be important in the physiology of several different neoplasms including those of the breast and female reproductive tract. Levels of CSF-1 and CSF-1R expression appear to correlate with tumor cell invasiveness and an adverse clinical prognosis and may be modulated by hormones involved in normal lactogenic differentiation. Also, it appears that CSF-1R activates several different signal transduction pathways but only some of these appear to have direct bearing on tumor cell phenotypes and the activation of pathways in specific cell types may depend on factors above and beyond the receptor itself.
Kascinski
Barry
B
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis* / Q000502:physiology; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*; D011379:Prognosis; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000096:biosynthesis* / Q000502:physiology; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D005938:Glucocorticoids; D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor