title: A protein from the mold Aspergillus giganteus is a potent inhibitor of fungal plant pathogens.
abstract: A purified preparation of antifungal protein (AFP) from Aspergillus giganteus exhibited potent antifungal activity against the phytopathogenic fungi Magnaporthe grisea and Fusarium moniliforme, as well as the oomycete pathogen Phytophthora infestans. Under conditions of total inhibition of fungal growth, no toxicity of AFP toward rice protoplasts was observed. Additionally, application of AFP on rice plants completely inhibited M. grisea growth. These results are discussed in relation to the potential of the afp gene to enhance crop protection against fungal pathogens in transgenic plants.
authors.affiliation: Departamento de Genética Molecular, Instituto de Biología Molecular de Barcelona, CID-CSIC, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Vila
authors.forename: V
authors.initials: V
authors.lastname: Lacadena
authors.forename: P
authors.initials: P
authors.lastname: Fontanet
authors.forename: A
authors.initials: A
authors.lastname: Martinez del Pozo
authors.forename: B
authors.initials: B
authors.lastname: San Segundo
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000235:genetics / Q000502:physiology*; D005656:Fungal Proteins / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D005670:Fusarium / Q000472:pathogenicity; D005800:Genes, Fungal; D020082:Magnaporthe / Q000472:pathogenicity; D012275:Oryza / Q000382:microbiology; D010838:Phytophthora / Q000472:pathogenicity; D010935:Plant Diseases / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents; D005656:Fungal Proteins