[A preliminary study on the markers of pulmonary vascular endothelial cells in patients with ARDS].
OBJECTIVE
To explore the changes of the markers of pulmonary vascular endothelial cell (PVEC) in patients with ARDS.


METHODS
The levels of plasma circulating endothelial cell(CEC), granule membrane protein-140(GMP-140), endothelin-1(ET-1) and von Willebrand factor (vWF) were determined respectively in 13cases of ARDS. The vWF on the surface of the PVEC were stained in 5 cases of ARDS.


RESULTS
Circulating CEC, GMP-140, ET-1 and vWF levels were increased significantly (P < 0.01) but scores of vWF expression on the PVEC became weak (P < 0.01) in ARDS samples. The level of plasma GMP-140 elevated dramatically in 2nd day( > 4 times).


CONCLUSIONS
PVEC are severely impaired during ARDS. GMP-140 released from PVEC might be a satisfactory criteria for early surveillance and for evaluation of prognosis of ARDS in clinical practice.
Li
Q
Q
Institute of Respiratory Diseases, Xingqiao Hospital, Third Military Medical University, Chongqing 400037.
Qian
G
G
Chen
Z
Z
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D019332:Endothelin-1 / Q000097:blood*; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D012128:Respiratory Distress Syndrome / Q000097:blood* / Q000473:pathology; D014841:von Willebrand Factor / Q000378:metabolism*
D015415:Biomarkers; D019332:Endothelin-1; D019007:P-Selectin; D014841:von Willebrand Factor