[Observation of therapeutic effect of Salviae miltiorrhiza and cytosine diphosphate-choline injection on patients with hypertensive cerebral hemorrhage].
OBJECTIVE
To assess the effect of Salviae miltiorrhiza (SM) injection in the treatment of hypertensive cerebral hemorrhage (HCH).


METHODS
Fifty-one cases (age 50-78 years, 61.2 years on average) of HCH were randomly divided into three groups (SM + cytosine diphosphate-choline (CDP-C) group and para-aminomethyl benzoic acid (PAMBA) + CDP-C group as treated group, CDP-C group as control group) to observe the outcome of the clinical treatment, hematoma absorbability and changes of ADP-platelet agglutination rate (Pag), prothrombin time(PT) and function of the liver and kidney.


RESULTS
The rate of good result (GR) and moderate disability (MD) in SM group was 85.71% with the method of Glasgow outcome score (GOS), others were 47.06% and 61.54% separately, they have significant difference, P < 0.05. Among them, SM group had best result. Compared the rate of hematoma absorbability of SM group with that of PAMBA, CDP-C groups, the difference was significant, P < 0.05. It did not affect the platelet coagulative function in SM group.


CONCLUSIONS
SM injection could effectively improve the condition of patients with HCH, and without any side effect. It is worthwhile to be used in the clinical practice.
Yu
W
W
Ruijin Hospital, Second Medical University, Shanghai (200025).
Shen
F
F
Ma
Z
Z
D000368:Aged; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D003566:Cytidine Diphosphate Choline