Synthesis and antiviral assays of some benzimidazole nucleosides and acyclonucleosides.
Some benzimidazole nucleosides and acyclonucleosides were synthesized and tested in vitro as antiviral agents. None of them showed significant activity. Replacement of the benzenesulphonyl group at N-1 with the ribofuranosyl moiety or with the acyclovir side-chain was deleterious.
Garuti
L
L
Department of Pharmaceutical Science, University of Bologna, Italy. lauga@alma.unibo.it
Roberti
M
M
Gentilomi
G
G
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D029822:Enterovirus B, Human / Q000187:drug effects*; D006367:HeLa Cells; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D017955:Poliovirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D009705:Nucleosides