[Experimental study on the effect of yiyuan shengxue capsule on gamma-interferon and tumor necrosis factor-alpha in patients with chronic aplastic anemia].
OBJECTIVE
To explore the effect of Yiyuan Shengxue capsule (YYSXC) on peripheral gamma-interferon (gamma-IFN) and tumor necrosis factor-alpha (TNF-alpha) in patients with chronic aplastic anemia (CAA).


METHODS
Applying the assay of microcell lesion inhibitory and L595 cytotoxicity test to detect gamma-IFN and TNF-alpha level 36 thirty-six cases with CAA before and after treatment with YYSXC.


RESULTS
To compare the test group with the normal group, the difference was significant before treatment (P < 0.05, P < 0.01), but after treatment, the difference was insignificant between these two groups (P < 0.05). To compare the group of Kidney Yin Deficiency with Kidney Yang Deficiency, both the difference of before and after treatment were significant. For the therapeutic effective rate, the group of Kidney Yang Deficiency was higher than that of Kidney Yin Deficiency.


CONCLUSIONS
YYSXC could treat CAA through reducing the level of peripheral gamma-IFN and TNF-alpha of CAA patients, and the effect was through regulating the dysfunctional immune state.
Zhang
L
L
460 Hospital of PLA, Zhengzhou (450007).
Wang
X
X
Chen
S
S
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000188:drug therapy*; D002214:Capsules; D002648:Child; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma