Different mechanism of bone loss in ageing women and men in Khon Kaen Province.
The changes of vitamin D status and biochemical markers of bone turnover have been reported with aging. In this study we determined age-related levels of vitamin D and biochemical markers of bone turnover in the general adult population between the ages of 20 and 84 years who were living in Khon Kaen province in northeastern Thailand. Serum 25 hydroxyvitamin D was determined as an indicator of vitamin D status. Serum total alkaline phosphatase and N-terminal mid fragment osteocalcin were measured as biochemical markers of bone formation and serum C-terminal fragment of type I collagen was measured as a marker of bone resorption. The levels of serum 25 hydroxyvitamin D were high in the Khon Kaen population. Men had higher levels of 25 hydroxyvitamin D than did women. However, there were no changes with age in either sex. In women, all biochemical markers of bone turnover increased with age after the fourth decade. The sharp increase was observed in the sixth decade which was around the menopausal age. In contrast, in men all biochemical markers of bone turnover except serum total alkaline phosphatase had a tendency to decrease with age.


CONCLUSIONS
There was no evidence of vitamin D deficiency in a Khon Kaen population. In addition, serum vitamin D levels did not decline with ageing. Women and men showed different changes of biochemical markers of bone turnover with ageing indicating gender difference in the pathogenesis of osteoporosis.
Chailurkit
L O
LO
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pongchaiyakul
C
C
Charoenkiatkul
S
S
Kosulwat
V
V
Rojroongwasinkul
N
N
Rajatanavin
R
R
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling / Q000502:physiology*; D002112:Calcifediol / Q000097:blood; D024042:Collagen Type I / Q000097:blood; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D012423:Rural Health / Q000706:statistics & numerical data*; D012727:Sex Characteristics; D017678:Sex Distribution; D013785:Thailand / Q000453:epidemiology; D014808:Vitamin D Deficiency / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism
D015415:Biomarkers; D024042:Collagen Type I; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D002112:Calcifediol