[Arterial infusion chemotherapy combined with concurrent radiotherapy for local advanced pancreatic cancer].
OBJECTIVE
To analyze the treatment results of un-resectable local pancreatic cancer by arterial infusion chemotherapy plus concurrent radiotherapy or radiotherapy alone.


METHODS
A total of 50 patients with local advanced pancreatic cancer from January 1992 through October 1995 were treated either by arterial infusion chemotherapy (C) plus concurrent radiotherapy (R) (22 cases) or by radiotherapy alone (28 cases). Radiation given was the same in the two groups of patients (50-60 Gy in 5 to 6 weeks, 1.8-2 Gy/Fx, 5 Fx/wk). Infusion chemotherapy was performed once every 4 weeks, consisting of 5-fluorouracil 1.0 g, mitomycin C 10 mg, cisplatin 60 mg. An average of 2.3 cycles was given to each patient.


RESULTS
Although the remission rate of jaundice and pain did not show significant difference between the two groups, patients in C + R treatment group had longer period of symptomatic remission (P < 0.05). The response rate (CR + PR) was 68.2% in C + R treatment group and 35.7% in R treatment group, respectively. The 1-, 2-, and 3-year survival rate was 75.3%, 36.8%, 25.4% in C + R treatment group, and 51.3%, 22.6%, 8.7% in R treatment group, respectively.


CONCLUSIONS
Arterial infusion chemotherapy combined with concurrent radiotherapy is a treatment of choice for patients with local unresectable cancer of the pancreas.
Liu
X
X
Fujian Provincial Tunor Hospital, Fuzhou 350014.
Chen
J
J
Yao
W
W
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000628:therapy*; D011879:Radiotherapy Dosage; D015996:Survival Rate
D000970:Antineoplastic Agents