Platelet glycoprotein complex Ia/IIa antibodies cause neonatal alloimmune thrombocytopenia but do not inhibit megakaryopoiesis and platelet recovery after allogeneic cord blood stem cell transplantation.
A sibling cord blood (CB) transplantation was performed in a boy with Wiskott-Aldrich syndrome. The CB (31 x 10(6) CD34(+) cells) derived from a newborn sister with neonatal alloimmune thrombocytopenia (NAIT) with 40,000 platelets/microl, caused by a maternal anti-HPA-5b and HLA-A2 antibody. Maternal serum did not inhibit clonogenicity after in vitro testing of megakaryopoiesis. Accordingly, this CB was accepted for sibling transplantation. The transplantation showed a good course with fast and sustained hematopoietic reconstitution (granulocytes >500/microl on day +16, platelets >50,000/microl on day +30). This case demonstrates a successful CB transplantation from a donor suffering from NAIT.
Cassens
U
U
Department of Transfusion Medicine/Transplantation Immunology, University Hospital Muenster, Muenster, Germany.
Garritsen
H
H
Kelsch
R
R
van der Werf
N
N
Frosch
M
M
Witteler
R
R
Ebell
W
W
Sibrowski
W
W
D015703:Antigens, CD / Q000276:immunology*; D016824:Antigens, Human Platelet / Q000276:immunology*; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D039421:Integrin alpha2; D016023:Integrins / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D009679:Nuclear Family; D038981:Receptors, Collagen; D013921:Thrombocytopenia / Q000097:blood / Q000151:congenital* / Q000276:immunology; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000276:immunology; D014923:Wiskott-Aldrich Syndrome / Q000628:therapy*
C055973:5b alloantigen, human; D015703:Antigens, CD; D016824:Antigens, Human Platelet; D039421:Integrin alpha2; D016023:Integrins; D007518:Isoantibodies; D038981:Receptors, Collagen