Lens fluorophotometry after trabeculectomy in primary open-angle glaucoma.
OBJECTIVE
To evaluate the loss of lens transparency incurred by patients undergoing trabeculectomy.


METHODS
A prospective cohort study.


METHODS
Data corresponding to 33 eyes of 33 consecutive patients with primary open-angle glaucoma (POAG) subjected to trabeculectomy (group 1) were compared with those corresponding to 12 eyes of 12 patients with POAG receiving topical antiglaucomatous treatment (group 2).


METHODS
Lens fluorophotometry was performed on the group 1 patients before and 12 months after surgery. In group 2, fluorophotometry was conducted at the onset of the study and at 12 months of follow-up.


METHODS
Starting and final lens autofluorescence and transmittance values corresponding to each subject group were compared.


RESULTS
In group 1, starting and final autofluorescence was 556.3 +/- 184.3 and 691.1 +/- 179.3 Eq ng/ml, and starting and final transmittance was 0.78 +/- 0.11 and 0.67 +/- 0.14, respectively. Respective values for group 2 were 574.3 +/- 94.8 and 595.2 +/- 107.0 Eq ng/ml and 0.72 +/- 0.17 and 0.71 +/- 0.16. The mean change between final and initial autofluorescence was statistically different between groups (134.7 +/- 123.7, group 1, 20.9 +/- 25.1 Eq ng/ml, group 2; P < 0.001). Similarly, a significant difference (P < 0.001) in transmittance change was observed between the surgery and control groups (-0.11 +/- 0.072, group 1; 0.02 +/- 0.008, group 2)


CONCLUSIONS
It was demonstrated by lens fluorophotometry that trabeculectomy in POAG leads to a loss in lens transparency.
Lazaro
Carlos
C
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense, 28005 Madrid, Spain.
Benitez-del-Castillo
Jose M
JM
Castillo
Alfredo
A
Garcia-Feijoo
Julian
J
Macias
Juana M
JM
Garcia-Sanchez
Julian
J
D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000175:diagnosis* / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D015590:Fluorophotometry; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007908:Lens, Crystalline / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D014130:Trabeculectomy / Q000009:adverse effects*; D014792:Visual Acuity