title: Discovery of montelukast: a once-a-day oral antagonist of leukotriene D4 for the treatment of chronic asthma.
authors.affiliation: Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire-Dorval, Québec, Canada H9R 4P8.
authors.forename: R N
authors.initials: RN
authors.lastname: Young
mesh_terms: D000085:Acetates / Q000032:analysis / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D002867:Chromones / Q000378:metabolism; D002908:Chronic Disease; D003521:Cyclopropanes; D006801:Humans; D020024:Leukotriene Antagonists / Q000032:analysis / Q000627:therapeutic use*; D017998:Leukotriene D4 / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D011804:Quinolines / Q000032:analysis / Q000627:therapeutic use*; D013440:Sulfides
chemical_list: D000085:Acetates; D002867:Chromones; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; D017998:Leukotriene D4; C006312:FPL 55712; C093875:montelukast