[Effect of xiaoqinglong decoction drug-serum on degranulation and histamine releasing of peritoneal mastocyte in sensitized rats].
OBJECTIVE
To study the mechanism of anti-allergic effect of Xiaoqinglong Decoction (XQLD).


METHODS
The influence of XQLD drug-serum frozen powder on degranulation and histamine releasing of peritoneal mastocyte in sensitized rats was examined by morphologic and fluorimetric method.


RESULTS
The drug-serum prepared by serum obtained 2 hours after medication for 15 min has obvious inhibitory effect on degranulation and histamine releasing of peritoneal mastocyte which showed a basically unified time-effect relationship.


CONCLUSIONS
The anti-allergic effect of XQLD is related with the allergic medium (histamine) inhibition of releasing of peritoneal mastocyte.
Li
Y
Y
Research Center of Pharmacology and Toxicology of Chinese Drugs, Shanghai TCM University, Shanghai (200032).
Wu
J
J
Wu
X
X
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D015550:Cell Degranulation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000378:metabolism* / Q000502:physiology; D010529:Peritoneal Cavity / Q000166:cytology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018926:Anti-Allergic Agents; D004365:Drugs, Chinese Herbal