[The inhibiting effect of glycyrrhizin on proliferation of the mice submandibular gland fibrosarcoma cell line in vitro].
OBJECTIVE
To study the inhibiting effect of glycyrrhizin on proliferation of the cell line of mice submandibular gland fibrosarcome in vitro.


METHODS
Light and electronic microscope examination, proliferative state of cells and cycle phase analysis were used.


RESULTS
Administration of glycyrrhizin above 600 mg/L could inhibit cell proliferation, and the effect was dose and time dependent. The morphological change of the cell line affected by glycyrrhizin could be seen with light and electronic microscope. Cell cycle phase analysis showed gLy-cyrrhizin gould stop cells shifting from G1 to S phase.


CONCLUSIONS
The Lowest inhibition concentration of glycyrrhizin to the cell line was above 600 mg/L, The antineoplastic effect of glycyrrhizin was possibly accomplished by interfering metabolism of G1 phase cells or/and blocking initiation of DNA synthesis.
Ge
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S
Deptment of Oral Maxillofacial Surgery, First Hospital, China Medical University, Shengyang 110001.
Lan
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X
Satoru
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S
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000473:pathology; D019695:Glycyrrhizic Acid / Q000494:pharmacology*; D051379:Mice; D013365:Submandibular Gland Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D019695:Glycyrrhizic Acid