Cytogenetic analysis in 61 couples with spontaneous abortions.
OBJECTIVE
To examine the relationship between spontaneous abortion and chromosomal abnormalities.


METHODS
Couples who had one or more consecutive spontaneous abortions and had normal genitals were enrolled for cytogenetic karyotype analysis.


RESULTS
In the 61 couples, the detected incidence was 11.5%, with five Robertsonian translocations, one reciprocal translocation, and one pericentric inversion of chromosome 7.


CONCLUSIONS
Chromosomal abnormalities may play an important role in fetal wastage.
Jiang
J
J
Department of Pediatrics, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
Fu
M
M
Wang
D
D
D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D007446:Chromosome Inversion; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic