title: The effects of sublingual glyceryl trinitrate on walking distance in patients with intermittent claudication. A randomised, doubled-blind, placebo-controlled, cross-over study.
abstract: BACKGROUND
  Intermittent claudication (IC) is a common problem in older age. New work shows that the administration of glyceryl trinitrate (GTN) can reduce the fall in ankle brachial pressure index (ABPI) after exercise and can increase maximum walking distance by 19% on treadmill exercise. The aim of this study was to further define the clinical benefits of GTN in patients with PVD.
  
  
  METHODS
  The study is of a randomised, double-blind, placebo-controlled cross-over design. We studied 29 patients with intermittent claudication where the median age was 67.5 years (45-84). This included 20 males and nine females, and six of these patients were diabetics. To be selected, the patients had to have a history of IC with a resting ABPI of 1.0 or less, that fell by more than 0.1 on exercise. Patients were walked for 15 min on flat ground following GTN spray or placebo and total distances walked were measured. This was then followed by the crossover component of the trial.
  
  
  RESULTS
  Median walking distance with placebo was 825 m (100-1300 m) and with GTN was 900 m (240-1400 m). This is an increase of 9% (p = 0.02, using the Wilcoxon matched pairs signed ranks test).
  
  
  CONCLUSIONS
  This study shows a statistically significant improvement in walking distance with GTN in patients with IC.
authors.affiliation: Department of Vascular and Endovascular Surgery, Queen's Medical Centre, Nottingham.rakeshheer@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Heer
authors.forename: S
authors.initials: S
authors.lastname: Walker
authors.forename: S
authors.initials: S
authors.lastname: MacSweeney
mesh_terms: D000286:Administration, Sublingual; D000368:Aged; D000369:Aged, 80 and over; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016138:Walking
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin