Expression of beta-catenin in renal cell carcinoma.
OBJECTIVE
To investigate the expression of beta-catenin and its mRNA in renal cell carcinoma.


METHODS
Twenty-six cases with renal cell carcinoma (RCC) were studied by immunohistochemistry, Western blot and RT-PCR.


RESULTS
We found the expression of beta-catenis is higher in cancer tissues than in normal kidney tissues and the level of beta-catenin is associated with the tumor stage. Its expression in tumor of pT3 and pT4 is obviously higher than pT1 and pT2 (P < 0.01). That is to say, there was an overexpression of beta-catenin protein in RCC and its level was related to the tumor stage, but the expression of beta-catenin mRNA had no difference between tumor tissue and normal tissue.


CONCLUSIONS
beta-catenin may be related to the occurrence and progress of RCC.
Zang
T
T
Department of Urology, First Hospital, Beijing Medical University, Institute of Urology, Beijing 100034, China.
Zhuang
L
L
Zhang
Z
Z
Xin
D
D
Guo
Y
Y
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D003598:Cytoskeletal Proteins / Q000032:analysis / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators; D051176:beta Catenin
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D012333:RNA, Messenger; D015534:Trans-Activators; D051176:beta Catenin