title: Treatment of in-stent coronary restenosis with excimer laser angioplasty.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of excimer laser coronary angioplasty (ELCA) with adjunctive balloon angioplasty in patient with in-stent restenosis.
  
  
  METHODS
  ELCA was performed in 20 patients of instent restenosis. All patients were symptomatic and had class III-IV angina. ELCA was performed with the Spectranetics CVX-300 System. The laser catheter of Vittesse C (concentric) and E (eccentric) with diameter of 1.4-2.0 mm was used.
  
  
  RESULTS
  Laser catheter crossed all stenotic stents without difficulty. The lesion length was 4.6-51.2 mm, mean 20.7 +/- 13.7 mm, including 14 lesions > 10 mm. Laser treatment alone increased minimal lumen diameter (MLD) from 0.3 +/- 0.3 mm to 1.4 +/- 0.3 mm (P < 0.0001) and improved the diameter stenosis from 88.8% +/- 10.0% to 46.0% +/- 8.0% (P < 0.0001). Adjunctive balloon angioplasty further increased minimal lumen diameter to 2.3 +/- 0.7 mm and reduced diameter stenosis to 14.2% +/- 8.2% (P < 0.0001). At follow-up (1-17 months, mean 8.9 +/- 5.7 months), 17 (85%) patients had remained asymptomatic, 3 (15%) patients had mild to moderate exertional angina, 1 (5%) patient received CABG.
  
  
  CONCLUSIONS
  ELCA with adjunctive percutaneous transluminal coronary angioplasty (PTCA) is an efficient and safe technique to debulk tissue in the patient with in-stent restenosis. The incidence of procedural related complication was low and ELCA may be used as a good method for in-stent restenosis treatment.
authors.affiliation: Grantham Hospital, Department of Cardiology, First Teaching Hospital, Beijing Medical University, Beijing 100034, China.
authors.forename: M
authors.initials: M
authors.lastname: Liu
authors.forename: W H
authors.initials: WH
authors.lastname: Chow
authors.forename: O H
authors.initials: OH
authors.lastname: Kwok
authors.forename: M H
authors.initials: MH
authors.lastname: Jim
authors.forename: A
authors.initials: A
authors.lastname: Yip
authors.forename: K
authors.initials: K
authors.lastname: Fan
authors.forename: E
authors.initials: E
authors.lastname: Chan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D017222:Angioplasty, Balloon, Laser-Assisted / Q000009:adverse effects; D023903:Coronary Restenosis / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents