title: Long-chain polyunsaturated fatty acids (LC-PUFA) during early development: contribution of milk LC-PUFA to accretion rates varies among organs.
abstract: Long-chain polyunsaturated fatty acids (LC-PUFA) accretion (essential for growth and neural development) was studied from late fetal throughout weaning age in the ferret, a species with maternal LC-PUFA sufficiency during pregnancy and lactation. The data show that a) accretion rate of LC-PUFA is rapid during early postnatal development, b) milk LC-PUFA decrease during lactation, c) adipose tissue LC-PUFA level is directly related to milk LC-PUFA level, while accretion in brain and liver exceeds dietary intake, d) accretion of arachidonic acid occurs earlier than docosahexaenoic acid, suggesting earlier development of n6-fatty acid endogenous synthesis.
authors.affiliation: Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hamosh
authors.forename: T R
authors.initials: TR
authors.lastname: Henderson
authors.forename: M A
authors.initials: MA
authors.lastname: Kemper
authors.forename: N M
authors.initials: NM
authors.lastname: Orr
authors.forename: A
authors.initials: A
authors.lastname: Gil
authors.forename: P
authors.initials: P
authors.lastname: Hamosh
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry; D004032:Diet; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000032:analysis / Q000502:physiology*; D005260:Female; D005289:Ferrets / Q000196:embryology / Q000254:growth & development*; D006801:Humans; D007774:Lactation; D008099:Liver / Q000254:growth & development; D008321:Mammary Glands, Animal / Q000737:chemistry / Q000378:metabolism; D008892:Milk / Q000737:chemistry*; D011247:Pregnancy
chemical_list: D005231:Fatty Acids, Unsaturated