title: [Adaptation to hyperthermia and changes in peripheral blood leukocytes in humans].
abstract: Heating humans up to rectal temperature 39.0-39.5 degrees C induces a heat stress and a physiological adaptation. Blood cells were found to produce nitric oxide under these conditions, neutrophiles playing a major role in the process. In our opinion, the HSC 70 takes part in the process of the long cell adaptation augmenting the cells' functional activity. Hyperthermia leads to a massive temporal HSP 72 expression in the blood mononuclears. This expression seems to be due to alterations in the cellular proteins and to oxidative stress.
authors.affiliation: Russian Military-Medical Academy, St. Petersburg, 194175, Lebedev St., 6, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Andreeva
authors.forename: V V
authors.initials: VV
authors.lastname: Goranchuk
authors.forename: E B
authors.initials: EB
authors.lastname: Shustov
authors.forename: A A
authors.initials: AA
authors.lastname: Boĭkova
authors.forename: V S
authors.initials: VS
authors.lastname: Petrova
authors.forename: M K
authors.initials: MK
authors.lastname: Rzhepetskaia
authors.forename: V N
authors.initials: VN
authors.lastname: Kuznetsov
authors.forename: I A
authors.initials: IA
authors.lastname: Men'shakov
authors.forename: B A
authors.initials: BA
authors.lastname: Margulis
authors.forename: P D
authors.initials: PD
authors.lastname: Shabanov
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D001794:Blood Pressure; D001833:Body Temperature Regulation; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006339:Heart Rate; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D007124:Immunoenzyme Techniques; D007376:Interleukin-2 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis; D020033:Protein Isoforms / Q000378:metabolism; D012129:Respiratory Function Tests
chemical_list: D018840:HSP70 Heat-Shock Proteins; D007376:Interleukin-2; D020033:Protein Isoforms; D009569:Nitric Oxide
vernacular_title: Adaptatsiia cheloveka k gipertermii i izmeneniia v leĭkotsitakh perifericheskoĭ krovi.