title: Acute renal failure in patients with rhabdomyolysis.
abstract: BACKGROUND
  Rhabdomyolysis is a relatively rare, not always diagnosed cause of acute renal failure (ARF). This fact motivated us to present the results of ARF treatment in the course of this polyetiological clinical syndrome.
  
  
  METHODS
  The analysis was performed on 84 patients (6 F, 78 M) ranging in age from 18 to 82 years (mean 46.5), in whom rhabdomyolysis was diagnosed based on clinical manifestation and laboratory test results (CPK, GTP, GOT, LDH).
  
  
  RESULTS
  The most frequent cause of rhabdomyolysis was alcoholic intoxication (41 patients), often accompanied by hypothermia (15 patients) or trauma (30 patients). Isolated trauma was found in 30 patients, epileptic seizure in 5, and physical exercise in 1 case. In 17 patients, besides alcohol consumption, trauma or epileptic seizure, the use of tranquilizers, anticonvulsants, or narcotic drugs was additionally noted. 78 patients developed ARF requiring dialysis therapy; 49 patients recovered, 5 required maintenance dialysis, and 30 died.
  
  
  CONCLUSIONS
  During the initial phase of ARF in the course of rhabdomyolysis dynamic increases in serum urea and creatinine were observed, as well as a tendency to hyperkalemia. The treatment results and mortality rate in our study group were primarily influenced by the patients' general condition at admission, as well as the extent of organ damage caused by the primary etiological factor. Favorable treatment results were obtained especially in those patients who were hospitalized in a nephrological center, while the worst outcomes were noted in those patients dialyzed in intensive care units, most with multiple trauma.
authors.affiliation: Department of Nephrology, Jagiellonian University Hospital, Cracow, Poland.
authors.forename: Wladyslaw
authors.initials: W
authors.lastname: Sułowicz
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Walatek
authors.forename: Antoni
authors.initials: A
authors.lastname: Sydor
authors.forename: Wladyslaw
authors.initials: W
authors.lastname: Ochmański
authors.forename: Andrzej
authors.initials: A
authors.lastname: Miłkowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szymczakiewicz-Multanowska
authors.forename: Dorota
authors.initials: D
authors.lastname: Szumilak
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kraśniak
authors.forename: Hanna
authors.initials: H
authors.lastname: Lonak
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Wójcikiewicz
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood; D004827:Epilepsy; D005260:Female; D006801:Humans; D007035:Hypothermia; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012206:Rhabdomyolysis / Q000150:complications* / Q000209:etiology; D014508:Urea / Q000097:blood; D014947:Wounds and Injuries
chemical_list: D014508:Urea; D003404:Creatinine