[Relationship between estrogen receptor genotypes and female bone mineral density].
OBJECTIVE
To observe the relationship between polymorphyism of estrogen receptor (ER) gene and bone mineral density (BMD) in women.


METHODS
Seventy-eight postmenopausal women, 23 perimenopausal women, and 52 young women (aged 25-35 years) were enrolled into the study. BMD was measured by dual energy X-ray absorptiometry at lumbar spine, proximal femur, fore-arm and total body. We also examined the restriction fragment length polymorphism of the polymerase chain reaction product (PCR-RFLPs) of the ER gene with XbaI or PvuII enzyme in these women.


RESULTS
There was no significant relationship between RFLP by PvuII or XbaI and BMD in 78 postmenopausal women. In young healthy women, the mean BMD at Ward triangle of genotype pp (0.823 +/- 0.095) g/cm2 was higher than that of genotype PP greater trochanter(0.665 +/- 0.071) g/cm2(P = 0.037). The BMD at total body, lumbar, hip, trochanter, and Ward of genotype xxpp were significantly higher than those of other genotypes (P < 0.05). But such differences were not found in postmenopausal women.


CONCLUSIONS
The genotype xxpp might indicate a higher BMD at total body, lumbar, hip, greater trochanter, and Ward in young women. There is no significant effect of ER genotype polymorphism defined by PvuII or XbaI on BMD in postmenopausal women.
Zhang
Q
Q
Department of Obstetrics and Gynecology of Memorial Hospital, Affiliated to Sun Yat-Sen University of Medical Science, Guangzhou 510120, China.
Yang
D
D
Kuang
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D005838:Genotype; D006801:Humans; D008593:Menopause / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*
D011960:Receptors, Estrogen