Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices.
OBJECTIVE
To investigate the relative effectiveness provided by a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride in a silica base (Colgate Sensitive Maximum Strength dentifrice) for reducing dentin hypersensitivity over an 8-wk period, as compared to that provided by a commercially-available antihypersensitivity dentifrice containing 5.0% potassium nitrate and 0.76% sodium monofluorophosphate in a dicalcium phosphate base (Fresh Mint Sensodyne dentifrice).


METHODS
To qualify for participation in this examiner-blind clinical study, male and female adults from the central New Jersey area were required to present with tactile and air blast dentin hypersensitivity in at least two non-molar teeth at two examinations, spaced 1 wk apart. Qualifying subjects were randomized into two treatment groups, which were balanced for gender, age, and baseline sensitivity scores. Subjects were provided with a soft-bristled toothbrush. Examinations for tactile and air blast sensitivity were repeated after 4 wks' use of the study dentifrices, and again after 8 wks' usage. 97 subjects complied with the protocol, and completed the entire study.


RESULTS
After 4 wks, subjects assigned to the Colgate Sensitive Maximum Strength dentifrice group exhibited a statistically significant improvement over the Sensodyne dentifrice group with respect to tactile sensitivity scores, and a statistically significant improvement over the Sensodyne dentifrice group with respect to air blast sensitivity scores. Correspondingly significant improvements were presented after 8 wks. Thus, the results of this examiner-blind clinical study support the conclusion that the Colgate Sensitive Maximum Strength dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride in a silica base provided superior levels of control of tactile and air blast sensitivity than the clinically tested, commercially-available anti-hypersensitivity dentifrice Sensodyne dentifrice containing 5.0% potassium nitrate and 0.76% sodium monofluorophosphate in a dicalcium phosphate base.
Sowinski
J A
JA
Department of Dental Hygiene, Erie Community College, Williamsville, NY 14221, USA. sowinski@ecc.edu
Bonta
Y
Y
Battista
G W
GW
Petrone
D
D
DeVizio
W
W
Petrone
M
M
Proskin
H M
HM
D000328:Adult; D000368:Aged; D000388:Air; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D045424:Complex Mixtures; D003802:Dentifrices / Q000008:administration & dosage / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000503:physiopathology / Q000517:prevention & control*; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage / Q000627:therapeutic use*; D014677:Pharmaceutical Vehicles; D010710:Phosphates / Q000627:therapeutic use*; D017680:Potassium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D012822:Silicon Dioxide; D016037:Single-Blind Method; D013223:Statistics as Topic; D014002:Tin Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D014099:Toothbrushing / Q000295:instrumentation; D014110:Touch / Q000502:physiology; D016896:Treatment Outcome
D002327:Cariostatic Agents; D045424:Complex Mixtures; D003802:Dentifrices; D004338:Drug Combinations; D009566:Nitrates; D014677:Pharmaceutical Vehicles; D010710:Phosphates; D017680:Potassium Compounds; C097427:Sensodyne; D014002:Tin Fluorides; C444700:colgate sensitive; D012822:Silicon Dioxide; D005459:Fluorides; C023844:potassium nitrate