Remodeling of cardiac gap junctions: the relationship to the genesis of ventricular tachycardia.
Cardiac gap junctions are responsible for normal conduction properties of the ventricles. Alteration in gap junction distribution (remodeling) in ischemic heart disease is likely to be an important cause of life threatening ventricular arrhythmias.
Wit
A L
AL
Department of Pharmacology and Center for Molecular Therapeutics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. alw4@columbia.edu
D016880:Anisotropy; D017629:Gap Junctions / Q000502:physiology*; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology; D017180:Tachycardia, Ventricular / Q000209:etiology* / Q000503:physiopathology; D020257:Ventricular Remodeling / Q000502:physiology*