AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy.
Large unilamellar magnetoliposomes (MLs) with encapsulated doxorubicin (DOX) (anticancer drug) were prepared by reverse-phase evaporation. They were exposed to an alternating magnetic field with a frequency of 3.5 MHz and an induction of 1.5 mT produced in three-turn pancake coil. The results showed that magnetoliposomes could be specifically heated to 42 degrees C (phase transition temperature of a used lipid) in a few minutes and during this, the encapsulated doxorubicin is massively released.
Babincová
M
M
Department of Biophysics and Chemical Physics, Comenius University, Mlynská dolina F1, 842 48 Bratislava, Slovakia. babincova@fmph.uniba.sk
Cicmanec
P
P
Altanerová
V
V
Altaner
C
C
Babinec
P
P
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008081:Liposomes; D008280:Magnetics
D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D004317:Doxorubicin