Effects of peripheral and central administration of GHRH on feeding in aging LOU rats.
In aging LOU rats, a decreased protein intake is restored by GH administration. To study the contribution of GHRH to macronutrient selection, hGHRH NH(2) was administered sc. (1 mg/kg B.W./day/14 days) or icv. (4 and 40 pmol/rat) to 11-, 19-, 24- and 28-month-old rats. Sc. administration induced a decreased food and lipid intakes from 24 months of age and a transient stimulation of protein intake in 19-month-old and older low protein eaters (<10% protein/total intake). Icv. administration induced decreased food and lipid intakes in all age groups. These results suggest that GHRH may regulate feeding through pituitary and/or hypothalamic GHRH receptor mechanisms.
Veyrat-Durebex
C
C
Laboratoire de Neuroendocrinologie du vieillissement, Université Blaise Pascal, 63177, Aubière, France.
Gaudreau
P
P
Boghossian
S
S
Alliot
J
J
D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D011863:Radioimmunoassay; D051381:Rats
D004044:Dietary Proteins; D007334:Insulin-Like Growth Factor I; D013007:Growth Hormone-Releasing Hormone