title: Effect of amylin on the tone of rat aorta ring preparation.
abstract: Amylin (10(-10)M) induced relaxation of norepinephrine-precontracted rat aortic rings by more than 50%. This effect was preserved after blockade of NO-synthase and even after denudation of the vessel. Thus amylin-induced vasodilation is an endothelium-independent process not mediated by NO.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
authors.forename: G V
authors.initials: GV
authors.lastname: Luk'yantseva
authors.forename: I Y
authors.initials: IY
authors.lastname: Sergeev
authors.forename: G N
authors.initials: GN
authors.lastname: Kopylova
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
authors.forename: S V
authors.initials: SV
authors.lastname: German
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000682:Amyloid / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D008297:Male; D009130:Muscle, Smooth / Q000166:cytology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
chemical_list: D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D019001:Nitric Oxide Synthase; D000109:Acetylcholine; D009638:Norepinephrine