title: Intravenous mirtazapine in the treatment of depressed inpatients.
abstract: Mirtazapine is a novel antidepressant with a noradrenergic and specific serotonergic mode of action. So far, mirtazapine has been administered orally. This naturalistic study evaluates the antidepressant efficacy, safety, and tolerability of mirtazapine 15 mg/day administered intravenously to 27 inpatients with moderate to severe major depression. Compared with baseline, we found a significant decrease of the Hamilton Depressive Rating Scale (HDRS) total score (P<0.001). Side effects were mild and transient. Altogether, the results of this preliminary study show that intravenous mirtazapine is an effective, safe and well tolerated treatment for depressed inpatients.
authors.affiliation: Department of General Psychiatry, University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Konstantinidis
authors.forename: J
authors.initials: J
authors.lastname: Stastny
authors.forename: J
authors.initials: J
authors.lastname: Ptak-Butta
authors.forename: E
authors.initials: E
authors.lastname: Hilger
authors.forename: D
authors.initials: D
authors.lastname: Winkler
authors.forename: C
authors.initials: C
authors.lastname: Barnas
authors.forename: A
authors.initials: A
authors.lastname: Neumeister
authors.forename: S
authors.initials: S
authors.lastname: Kasper
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001519:Behavior / Q000187:drug effects; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008803:Mianserin / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D000078785:Mirtazapine
chemical_list: D000317:Adrenergic alpha-Antagonists; D008803:Mianserin; D000078785:Mirtazapine