[Anti-arrhythmia effects of enkephalinase inhibitors].
The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine), is related to activation of the delta-opioid receptors by endogenous enkephalins. At the same time, the mu-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.
Lishmanov
Iu B
IuB
Laboratory of Experimental Cardiology, Institute of Cardiology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, ul. Shevchenko 24, Tomsk, 634050 Russia.
Maslov
L N
LN
Uskina
E V
EV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D018826:CD13 Antigens / Q000037:antagonists & inhibitors; D004220:Disulfides / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004837:Epinephrine; D008297:Male; D015260:Neprilysin / Q000037:antagonists & inhibitors*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists; D017450:Receptors, Opioid, mu / Q000819:agonists; D015244:Thiorphan / Q000031:analogs & derivatives* / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D004220:Disulfides; D004791:Enzyme Inhibitors; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; C074024:RB 101; D010649:Phenylalanine; C049331:racecadotril; D015244:Thiorphan; D018826:CD13 Antigens; D015260:Neprilysin; D004837:Epinephrine
Antiaritmicheskiĭ éffekt ingibitorov énkefalinaz.