title: Effect of corneal wetting solutions on corneal thickness during ophthalmic surgery.
abstract: OBJECTIVE
  To measure the changes in corneal thickness with wetting solutions used in ophthalmic surgery.
  
  
  METHODS
  Ege University, School of Medicine, Department of Ophthalmology, Izmir, Turkey.
  
  
  METHODS
  Thirty-one adult pigmented rabbits that weighed about 2.5 kg each were anesthetized with pentobarbital sodium. The rabbits were randomly divided into 3 groups to receive 3 wetting solutions: Group 1, Ringer's lactate; Group 2, balanced salt solution (BSS); and Group 3, BSS with glutation (BSS Plus). The solutions were dropped on the right cornea of the rabbits at a rate of 6.0 cc in 12 minutes using an intravenous infusion pump. Corneal thickness was measured by ultrasonic pachymetry before and after the procedure, and the between-group changes in corneal thickness were compared.
  
  
  RESULTS
  The corneal thickness before and after the procedure was 361.27 microm +/- 19.3 (SD) and 380.00 +/- 25.0 microm, respectively, in Group 1 (P =.000); 372.10 +/- 18.8 microm and 388.60 +/- 24.1 microm, respectively, in Group 2 (P =.003); and 358.10 +/- 26.5 microm and 360.10 +/- 24.1 microm, respectively, in Group 3 (P =.316).
  
  
  CONCLUSIONS
  As a corneal wetting solution, BSS Plus resulted in significantly fewer changes in corneal thickness than Ringer's lactate or BSS. This should be considered in cases involving long intraocular surgery.
authors.affiliation: Department of Ophthalmology, School of Medicine, Ege University, 351000 Bornova-Izmir, Turkey. sinan.emre@mailexcite.com
authors.forename: Sinan
authors.initials: S
authors.lastname: Emre
authors.forename: Cezmi
authors.initials: C
authors.lastname: Akkin
authors.forename: Filiz
authors.initials: F
authors.lastname: Afrashi
authors.forename: Ayşe
authors.initials: A
authors.lastname: Yağci
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D004338:Drug Combinations; D005978:Glutathione / Q000494:pharmacology*; D007552:Isotonic Solutions / Q000494:pharmacology*; D008903:Minerals / Q000494:pharmacology*; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D013508:Ophthalmologic Surgical Procedures; D011817:Rabbits; D011897:Random Allocation; D000077325:Ringer's Lactate; D012965:Sodium Chloride / Q000494:pharmacology*
chemical_list: D000085:Acetates; C030660:BSS solution; D001639:Bicarbonates; D004338:Drug Combinations; D007552:Isotonic Solutions; D008903:Minerals; D009883:Ophthalmic Solutions; D000077325:Ringer's Lactate; C013003:glutathione-bicarbonate-Ringer solution; D012965:Sodium Chloride; D005978:Glutathione