title: [A one-year study on enzyme level in gingival crevicular fluid around osseointegrated dental implants].
abstract: OBJECTIVE
  To investigate the changes of gingival crevicular fluid(GCF) volume, aspartate aminotransferase (AST) and alkaline phosphatase(ALP) levels in GCF around dental implants during the first year after rehabilitation. And to explore the relationships between these changes and peri-implant inflammation as well as bone loss.
  
  
  METHODS
  26 Branemark implants in 12 adults were included in this study. Examinations were carried out in a total of 52 sites in preinsertion period and 3, 6, 12 months following rehabilitation.
  
  
  RESULTS
  GCF volume, GCF-AST, GCF-ALP were firstly increased and then fallen during the first year after rehabilitation. GCF volume, GCF-AST, GCF-ALP in sites with peri-implant mucositis were higher than those in health sites, and were increased with the severity of peri-implant mucositis. GCF volume, GCF-AST, GCF-ALP in sites with bone loss were significantly higher than those without bone loss.
  
  
  CONCLUSIONS
  GCF volume, GCF-AST, GCF-ALP could reflect peri-implant inflammation and bone changes to some degree.
authors.affiliation: Department of Oral Medicine, Stomatological Hospital, Medical College, Zhejiang University, Hangzhou 310006, China.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Sha
authors.forename: C
authors.initials: C
authors.lastname: Cao
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003758:Dental Implantation, Endosseous; D005260:Female; D005883:Gingival Crevicular Fluid / Q000201:enzymology*; D006801:Humans; D008297:Male; D013997:Time Factors
chemical_list: D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase