Effects of oral coenzyme Q10 supplementation on sodium nitrite-induced lipid peroxidation in rats.
Studies were carried out to examine the anti-oxidative effect(s) of oral coenzyme Q10 supplementation (10 mg/kg b.w./day) in rats treated per os with either sodium nitrite (10 mg/kg b.w./day) or saline (control) for 14 days. Results showed that sodium nitrite increases thiobarbituric-acid reactive substances (TBARS in rat small intestinal mucosa and liver, and the agent did not have any effect(s) on the total anti-oxidant status (TAS) and lipid peroxidation of rat blood. Pretreatment of nitrite-poisoned rats with coenzyme Q10 mitigated TBARS and increased TAS in animal blood. Coenzyme Q10 has been found to be a promising anti-oxidant agent in sodium nitrite-induced lipid peroxidation.
Grudziński
I P
IP
Department of Applied Physiology, Military Institute of Hygiene and Epidemiology, Warsaw.
Frankiewicz-Jóźko
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A
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D002273:Carcinogens; D056486:Chemical and Drug Induced Liver Injury; D003067:Coenzymes; D007421:Intestine, Small / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008107:Liver Diseases / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009566:Nitrates; D010084:Oxidation-Reduction; D010865:Pilot Projects; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000975:Antioxidants; D002273:Carcinogens; D003067:Coenzymes; D009566:Nitrates; D017392:Thiobarbituric Acid Reactive Substances; D014451:Ubiquinone; C031618:sodium nitrate; C024989:coenzyme Q10