title: Modeling modulus reduction in bovine trabecular bone damaged in compression.
abstract: Loading bone beyond its yield point creates microdamage, leading to reduction in stiffness. Previously, we related microdamage accumulation to changes in mechanical properties. Here, we develop a model that predicts stiffness loss based on the presence of microdamage. Modeling is done at three levels: (1) a single trabecula, (2) a cellular solid consisting of intact, damaged, and fractured trabeculae, and (3) a specimen with a localized damage band. Predictions of a reduced modulus agree well with experimental measured modulus reductions of post-yield compression of bovine trabecular bone. The predicted reduced modulus is relatively insensitive to changes in the input parameters.
authors.affiliation: Division of Health Sciences and Technology, Harvard Medical School-Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: T L
authors.initials: TL
authors.lastname: Moore
authors.forename: L J
authors.initials: LJ
authors.lastname: Gibson
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000473:pathology* / Q000503:physiopathology*; D002417:Cattle; D019245:Compressive Strength / Q000502:physiology*; D004548:Elasticity; D050723:Fractures, Bone / Q000473:pathology / Q000503:physiopathology*; D008954:Models, Biological; D015203:Reproducibility of Results; D013314:Stress, Mechanical