title: Prognostic value of TP53 gene mutation in adjuvant treated breast cancer patients.
abstract: We investigated the prognostic significance of mutation to the TP53 tumor suppressor gene in a series of 908 breast cancer patients treated with or without adjuvant therapies. The frequency of TP53 mutation detected by single strand conformation polymorphism (SSCP) was 19.4% (176/908) in the overall tumor series. In multivariate analysis, TP53 mutation was independently associated with worse survival in the overall (HR = 2.1, 95% CI [1.5-3.1], P<0.0001), non-adjuvant treated (HR=2.2, 95% CI [1.2-4.2], P=0.017) and adjuvant treated (HR= 2.0, 95% CI [1.3-3.1], P = 0.0009) patients.
authors.affiliation: Department of Surgery, University of Western Australia, Nedlands, Australia.
authors.forename: B L
authors.initials: BL
authors.lastname: Powell
authors.forename: S
authors.initials: S
authors.lastname: Bydder
authors.forename: F
authors.initials: F
authors.lastname: Grieu
authors.forename: G
authors.initials: G
authors.lastname: Gnanasampanthan
authors.forename: H
authors.initials: H
authors.lastname: Elsaleh
authors.forename: R
authors.initials: R
authors.lastname: Seshadri
authors.forename: E M
authors.initials: EM
authors.lastname: Berns
authors.forename: B
authors.initials: B
authors.lastname: Iacopetta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D004273:DNA, Neoplasm