[Mandibular compound organs allotransplantion in canines].
OBJECTIVE
To evaluate the feasibility of transplanting composite madibular allogratts to reconstruct large mandibular defects.


METHODS
Three composite mandibular transplantation models were designed. The first consisted of hemimandible with the attached teeth, muscles and skin, and oral mucosa. The second was transplanted as the first excluding oral mucosa and some teeth, and the third excluding oral mucosa and all dental crowns. Fourteen transplanting operations were done in canines. Cyclosporine A and methylprednisone were given for immunosuppression.


RESULTS
It was confirmed that the composite mandibular organs had an effective and closed return circuit. Transplantation of vascularized mandibular compound organs allografts was feasible. Two longest survivors. 67 and 76 days, were in the third model. Cyclosporine A was successful in suppressing rejection in composite allograft transplant and prolonging survival of transplant models.


CONCLUSIONS
The compoite mandibular allografts had the availability of large bloc of living composite tissues and the good restoration of appearance and function for severe mandibular defects.
Hu
M
M
School of Stomatology, Beijing Medical University, Beijing 100081.
Zhang
Z
Z
Zhang
X
X
D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use; D004285:Dogs; D008334:Mandible / Q000637:transplantation*; D018529:Nutritional Support; D014184:Transplantation, Homologous
D016572:Cyclosporine