title: [The changes of transforming growth factor beta 1 in periodontal tissue during orthodontic tooth movement].
abstract: OBJECTIVE
  To observe the distribution and change of transforming growth factor beta 1 (TGF-beta 1) in periodontal tissue and understand the role of TGF-beta 1 in orthodontic tooth movement.
  
  
  METHODS
  Apply force on right maxillary first molars in rats, and examine the decalcified alveolodental connected tissue in different stage of tooth movement with immunohistochemical staining technique (SP method).
  
  
  RESULTS
  TGF-beta 1 exists in normal periodontal tissue. The expression of it in periodontium increases during orthodontic tooth movement. Especially from 5 to 10 days after force application, the expression at tension side is much more than those at pressure side.
  
  
  CONCLUSIONS
  TGF-beta 1 plays an important role in remodeling of periodontal tissue during orthodontic tooth movement, and can powerfully promote bone formation.
authors.affiliation: School of Stomatology, Bethune University of Medical Science, Changchun 130041.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Zhu
authors.forename: T
authors.initials: T
authors.lastname: Liang
mesh_terms: D000818:Animals; D007150:Immunohistochemistry; D010519:Periodontium / Q000737:chemistry* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014087:Tooth Movement Techniques; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053773:Transforming Growth Factor beta1
chemical_list: C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1