DNA analysis of abortion material assisted by histology screening.
In cases of rape leading to fertilization, paternity testing can retrospectively identify the assailant. Abortion material commonly represents a mixture of maternal and fetal tissue and blood, which cannot be differentiated with the naked eye. Consequently, DNA typing of abortion material may be complicated, including band overlap if maternal tissue predominates. Therefore, histology screening of the abortion content for typical fetal tissue components, such as chorionic villi, followed by selected DNA typing of this sample is suggested. This combined approach is illustrated by a selected case demonstrating the reliability and concurrence of the histology and genetic results.
Karger
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Institute of Legal Medicine, University of Münster, Germany. Karger@uni-meunster.de
Rand
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SP
Duchesne
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A
D000028:Abortion, Induced; D000293:Adolescent; D002650:Child Abuse, Sexual / Q000175:diagnosis*; D002824:Chorionic Villi / Q000033:anatomy & histology; D016172:DNA Fingerprinting / Q000379:methods*; D005260:Female; D005333:Fetus; D006652:Histological Techniques / Q000379:methods; D006801:Humans; D008297:Male; D010334:Paternity; D011247:Pregnancy; D011253:Pregnancy in Adolescence / Q000235:genetics*