[Comparative study of three different chemotherapy protocols for advanced non-small-cell lung cancer].
OBJECTIVE
To compare the efficacy and toxicity of three different chemotherapy protocols for advanced non-small-cell lung cancer (NSCLC).


METHODS
The clinical data of 93 cases with advanced NSCLC treated with (1) ifosfamide plus vindesine plus cisplatin (IVP, 31 cases), (2) mitomycin C plus vindesine plus cisplatin (MVP, 30 cases), and (3) cyclophosphamide plus adriamycin plus cisplatin (CAP, 32 cases) were analysed.


RESULTS
The response rate was 48.4% in patients treated with IVP, 40.0% in those treated with MVP, and 28.1% in those with CAP, respectively. The major toxic reactions in the three groups were tolerable myelo-suppression and hair loss.


CONCLUSIONS
IVP and MVP are effective and safe chemotherapeutic protocols for the treatment of advanced NSCLC patients.
Chen
L
L
Department of Medical Oncology, Nanjing General Hospital, Nanjing Command of PLA, Nanjing 210002.
Wang
J
J
Chu
X
X
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged