[Relevance of Fc gamma R polymorphism to the susceptibility of early-onset periodontitis].
OBJECTIVE
To investigate the polymorphism of the Fc gamma R genotype and its association with the susceptibility of early-onset periodontitis (EOP).


METHODS
DNA of the white blood cells from 33 subjects with EOP and 27 healthy controls was extracted. Genotypes of the Fc gamma RIIA and Fc gamma RIIIB were determined by PCR followed by BstUI restriction endonuclease digestion and DNA sequencing, respectively. Then compared the differences in distribution of each genotype.


RESULTS
No statistical difference in distribution of Fc gamma RIIA was observed between patients and controls. However, a significant over-representation of the Fc gamma RIIIB NA1/NA1 was found in EOP.


CONCLUSIONS
These results suggest that the Fc gamma RIIIB NA1/NA1 may be a risk indicator for the susceptibility of the EOP.
Fu
Y
Y
School of Stomatology, Beijing Medical University, Beijing 100081.
Cao
C
C
Wang
S
S
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D010518:Periodontitis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*
D017452:Receptors, IgG; D004247:DNA