Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry.
Qiu
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Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446, USA.
Benet
L Z
LZ
Burlingame
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AL
D000082:Acetaminophen / Q000008:administration & dosage / Q000378:metabolism*; D000083:Acetanilides / Q000008:administration & dosage / Q000378:metabolism*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D008099:Liver / Q000378:metabolism*; D013058:Mass Spectrometry; D051379:Mice; D008810:Mice, Inbred C57BL; D011506:Proteins / Q000378:metabolism*
D000083:Acetanilides; D018712:Analgesics, Non-Narcotic; D011506:Proteins; D000082:Acetaminophen; C026137:3-hydroxyacetanilide