CDP-choline, but not cytidine, protects hippocampal CA1 neurones in the gerbil following transient forebrain ischaemia.
The effects of CDP-choline (citicoline), cytidine monophosphate or cytidine on the number of CA1 hippocampal neurones surviving five-minute forebrain ischaemia have been evaluated in gerbils. The substances tested were given in daily doses equivalent on a molar basis to 500 mg/kg CDP-choline, starting immediately after ischaemia. On day five the brains were perfused, postfixed, cut into 10 microm slices and stained with cresyl violet, and the number of neurones in the CA1 sectors was counted manually under a light microscope at magnification x 400. The results indicate a significant degree of protection provided by citicoline, but no protection by cytidine monophosphate or cytidine. The choline moiety of CDP-choline appears to be essential for the neuroprotective properties of the drug.
Grieb
P
P
Laboratory of Experimental Pharmacology, Medical Research Centre, Polish Academy of Sciences, Warszawa. pgrieb@cmdik.pan.pl
Gadamski
R
R
Wojda
R
R
Janisz
M
M
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects* / Q000648:ultrastructure*; D003562:Cytidine / Q000494:pharmacology; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology* / Q000627:therapeutic use*; D003568:Cytidine Monophosphate / Q000494:pharmacology; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D016548:Prosencephalon / Q000187:drug effects / Q000473:pathology
D015220:Calcium Channels; D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline; D003562:Cytidine; D003568:Cytidine Monophosphate