[Interrelations between sympathetic adrenal and opioid systems--regulatory mechanism determining cardiac resistance to stress damage].
The present paper has analyzed relationship between sympatico-adrenal and opioid systems in the pathogenesis of stress heart damage. Based on the our own results and other investigator data the authors make a conclusion that namely relationship between opioid and sympatico-adrenal systems both on the level of the brain and on the periphery determines a degree of the heart resistance to the injury action of severe stress. Myocardial protection by opioids at stress was found to be mediated by the peripheral mu-opioid receptors and was associated with decrease in an activity of sympatico-adrenal system and a inhibition of its effector part. On contrary central opioid system activation leads to an increase in stress heart damage via an increase in sympathetical influence on the myocardium.
Naryzhnaia
N V
NV
Institute of Cardiology, Tomsk Scientific Center, Russian Academy of Medical Science.
Maslov
L N
LN
Revinskaia
Iu G
IuG
Lishmanov
Iu B
IuB
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D006801:Humans; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011957:Receptors, Opioid / Q000378:metabolism*; D017465:Receptors, Opioid, delta / Q000378:metabolism; D017473:Receptors, Opioid, kappa / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000378:metabolism; D013312:Stress, Physiological / Q000150:complications / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism*
D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu
Vzaimodeĭstvie simpatoadrenalovoĭ i opioidnoĭ sistem kak reguliatornyĭ mekhanizm, opredeliaiushchiĭ ustoíchivost' serdtsa k povrezhdaiushchemu deĭstviiu stressa.