[Effect of caoguo zhimu decoction on N-methyl-D-aspartate receptor gene expression of epileptic kindling model in rats].
OBJECTIVE
To explore the effect of Caoguo Zhimu decoction (CGZMD) on N-methyl-D-aspartate (NMDA) receptor gene expression of epileptic model on rat brain.


METHODS
Adopting the pentylenetetrazol (PTZ) kindling model to observe the NMDAR1 mRNA gene expression by situs hybridization.


RESULTS
After 28 days of CGZMD treatment, the NMDAR1 mRNA gene expression on CA1, CA2, CA3 part of rat hippocampus reduced obviously, the comparison between experimental group and the model control group showed significant difference (P < 0.05).


CONCLUSIONS
CGZMD decreased NMDAR1 mRNA gene expression, it may be caused the NMDA receptor decline, hence revealed its anti-epileptic effect.
He
J
J
Beijing University of TCM, Beijing (100029).
Liang
Y
Y
Wang
H
H
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004827:Epilepsy / Q000235:genetics* / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007696:Kindling, Neurologic; D008297:Male; D008959:Models, Neurological; D010433:Pentylenetetrazole; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis* / Q000235:genetics
D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D010433:Pentylenetetrazole