[Current opinions on embryotoxic and teratogenic effects of ibuprofen].
Ibuprofen is a non-selective cyclooxygenase (COX) inhibitor with analgesic, antipyretic and antiinflammatory activity. Experimental, clinical and epidemiological studies, led on a wide scale, showed high therapeutically activity and good drug tolerability, especially for low doses in adult and children older then 6 months. Those data let to positioned ibuprofen to over-the-counter (OTC) drugs. However, unlike well-documented tolerability studies of the postnatal period the prenatal data are still unclear. Results of experimental studies showed ibuprofen-dependent: implantation disturbances, blocking of parturition, and contraction of ductus arteriosus what could produce persistent pulmonary hypertension. These data has been partially confirmed in human studies. Lack teratogenic effect was observed in in vivo animal studies. Gastroschisis is the only congenital ibuprofen-related malformation that was proved in big epidemiological human studies. Other congenital anomalies and disturbances, such as oligohydramnion, associated with maternal ibuprofen ingestion, and reported in available literature, have not been established in epidemiological studies.
Burdan
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Pracownia Teratologii Doświadczalnej przy Katedrze i Zakładzie Anatomii Prawidłowej Człowieka AM w Lublinie. frank@tkt.net.pl
Bełzek
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D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D020139:Gastroschisis / Q000139:chemically induced*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D007231:Infant, Newborn; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen
Współczesne poglady na embriotoksyczne i teratogenne działanie ibuprofenu.