title: Mineralized corneal sequestrum in a cat.
abstract: An 8-month-old 3-kg (6.6-lb) sexually intact male cat was evaluated for chronic refractory keratitis and a corneal plaque that developed after treatment with a corticosteroid-containing ophthalmic preparation. Pertinent ophthalmic findings included blepharospasm, conjunctivitis, corneal vascularization, and a tan raised corneal plaque with a dense and gritty composition. Lamellar keratectomy was performed to excise the plaque. The cornea healed with mild scarring. Histologic examination revealed extensive coagulation necrosis and mineralization of the corneal stroma with increased inflammatory cells, blood vessels, and fibrosis, which is compatible with a diagnosis of mineralized corneal sequestrum. The history suggested chronic feline herpesvirus-1 (FHV-1)-induced keratoconjunctivitis as the underlying cause. Topical corticosteroid administration may have potentiated the preexisting corneal necrosis and initiated mineralization. To our knowledge, mineralization of a corneal sequestrum in a cat has not been reported in a clinical case but has been reported in cats experimentally infected with FHV-1.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University Columbus 43210, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Gemensky
authors.forename: D A
authors.initials: DA
authors.lastname: Wilkie
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D002415:Cats; D003315:Cornea / Q000473:pathology*; D003320:Corneal Ulcer / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D015828:Eye Infections, Viral / Q000150:complications / Q000662:veterinary*; D006566:Herpesviridae Infections / Q000150:complications / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D008903:Minerals; D009336:Necrosis; D009883:Ophthalmic Solutions; D018140:Varicellovirus / Q000302:isolation & purification*
chemical_list: D000305:Adrenal Cortex Hormones; D008903:Minerals; D009883:Ophthalmic Solutions