title: Pathophysiologic mechanisms in atopic dermatitis.
abstract: Atopic dermatitis is a common, chronic inflammatory skin disease that frequently predates the development of asthma and/or allergic rhinoconjunctivitis. Recent studies have provided new insights into how the complex interrelationship of genetic, environmental, and immunologic factors may contribute to the development of atopic dermatitis. This article examines some of the factors involved in chronic cutaneous inflammation in this disease. Greater understanding of the mechanisms that underlie the pathophysiology of atopic dermatitis may lead to improved treatment strategies for this increasingly common skin disease.
authors.affiliation: Division of Pediatric Allergy-Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA.
authors.forename: M
authors.initials: M
authors.lastname: Boguniewicz
authors.forename: D Y
authors.initials: DY
authors.lastname: Leung
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D001324:Autoantigens / Q000097:blood; D019703:Calcineurin / Q000276:immunology; D065095:Calcineurin Inhibitors; D002908:Chronic Disease; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D003876:Dermatitis, Atopic / Q000201:enzymology / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007801:Langerhans Cells / Q000276:immunology; D012307:Risk Factors; D013211:Staphylococcus aureus / Q000472:pathogenicity; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001324:Autoantigens; D065095:Calcineurin Inhibitors; D016207:Cytokines; D007073:Immunoglobulin E; D019703:Calcineurin; D015105:3',5'-Cyclic-AMP Phosphodiesterases