Peroxisome proliferator-activated receptor-alpha activation and high-density lipoprotein metabolism.
Recently, considerable progress has been made in understanding the molecular basis of lipoprotein metabolism, including the role of peroxisome proliferator-activated receptor (PPAR)-alpha--the specific transcription factor which, when activated, influences the expression of genes encoding for proteins involved in high-density lipoprotein (HDL) metabolism. Because the fibrates have a direct effect on PPAR-alpha and, in turn, on 5 key genes that determine lipoprotein structure and function, they are able to exert a multiple influence on HDL metabolism. Increased HDL synthesis, accelerated efflux of cholesterol, and its hepatic uptake are the ultimate outcome of fibrate influence, with a consequent enhancement of the protective effect of HDL cholesterol.
Fruchart
J C
JC
Department of Atherosclerosis, Pasteur Institute of Lille, UR 545 INSERM, Lille, France. jean-charles.fruchart@pasteur-lille.fr
D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D001053:Apolipoproteins / Q000235:genetics / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism*; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D018528:ATP-Binding Cassette Transporters; D001053:Apolipoproteins; D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D008071:Lipoprotein Lipase