[Photographic documentation of the effectiveness of 1 mg. oral finasteride in treatment of androgenic alopecia in the man in routine general practice in Switzerland].
A 6-month, prospective, open, multicenter cohort study in 265 men with male pattern hair loss treated with oral finasteride 1 mg/day (Propecia) was conducted in the office of 52 Swiss dermatologists. The patient's head was placed in a stereotactic device, and Polaroid photographs were taken of the vertex and frontal areas. Endpoints used to determine treatment efficacy were patient self-assessment, investigator clinical assessment, and blinded assessment of the serial Polaroid photographs by a panel of 2 experienced dermatologists. Significant improvements were stated on the photographs by both clinical investigators and the blinded expert panel: 54% of patients showed improvement of hair growth at 6 months of treatment in the vertex region, and 48.7% in the frontal area. No progression of hair loss was found in an additional 38% (vertex) and 47% (frontal region), respectively. Clinical investigator and expert assessment yielded comparable results. Independently, patient self-assessment and investigator clinical assessment confirmed the progress. Propecia was well-tolerated, and no significant safety concerns were identified during the study. The photographic method was well accepted by the physicians. The office-based Polaroid photographic system allowed reliable assessment of change during treatment of male pattern hair loss with Propecia. The data generated in this manner corresponded to the antecedent results of the multicenter, placebo-controlled studies with oral finasteride.
Trüeb
R M
RM
Dermatologische Klinik, Universitätsspital Zürich. ramitru@derm.unizh.ch
Itin
P
P
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000505:Alopecia / Q000188:drug therapy*; D015331:Cohort Studies; D004282:Documentation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D018120:Finasteride / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010781:Photography / Q000295:instrumentation*; D011446:Prospective Studies; D013557:Switzerland; D016896:Treatment Outcome
D018120:Finasteride
Fotografische Dokumentation der Wirksamkeit von 1 mg oralem Finasterid in der Behandlung der androgenetischen Alopezie des Mannes im Praxisalltag in der Schweiz.