Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms.
We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.
Momose
Yoshio
Y
Division of Functional Genomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, Osaka, Japan.
Murata
Miho
M
Kobayashi
Kazuhiro
K
Tachikawa
Masaji
M
Nakabayashi
Yuko
Y
Kanazawa
Ichiro
I
Toda
Tatsushi
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004298:Dopamine / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013869:Thiolester Hydrolases / Q000235:genetics; D043222:Ubiquitin Thiolesterase
D019208:Brain-Derived Neurotrophic Factor; D003577:Cytochrome P-450 Enzyme System; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; D004298:Dopamine