Modeling the influence of TH1- and TH2-type cells in autoimmune diseases.
A sharp TH1/TH2 dichotomy has often been used to define the effects of cytokines on autoimmune diseases. However contradictory results in recent research indicate that the situation may be more complex. Here, we build a simple mathematical model aimed at settling the contradictions. The model is applied using Ordinary Differential Equations (ODE). We show here that a TH1/TH2 paradigm is only an external view of a complex multivariate system.
Louzoun
Y
Y
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. ylouzoun@princeton.edu
Atlan
H
H
Cohen
I R
IR
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D051381:Rats; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*