Influence of human immunodeficiency virus type 1 infection on acute hepatitis A virus infection.
To assess the possible influence of human immunodeficiency virus type 1 (HIV-1) infection on the clinical course of acute hepatitis A virus (HAV) infection, 15 HIV-1-infected homosexual men and 15 non-HIV-infected age-matched subjects were compared. HAV load was higher in HIV-1-infected than in non-HIV-infected patients (P<.001). Duration of viremia in HIV-1-infected patients (median, 53 days) was significantly (P<.05) longer than in non-HIV-infected patients (median, 22 days). HIV-1-infected patients had lower elevations in alanine aminotransferase levels than did non-HIV-infected patients (P<.01) but had higher elevations in alkaline phosphatase levels than did non-HIV-infected patients (P<.001). Some HIV-1-infected patients still had HAV viremia when clinical symptoms had disappeared and alanine aminotransferase levels had returned to normal (60-90 days after the onset of symptoms). HIV-1 infection was associated with prolongation of HAV viremia, which might cause a long-lasting outbreak of HAV infection in HIV-1-infected homosexual men.
Ida
Setsuko
S
AIDS Clinical Center, International Medical Center of Japan, Tokyo 162-8655, Japan.
Tachikawa
Natsuo
N
Nakajima
Aya
A
Daikoku
Manabu
M
Yano
Michitami
M
Kikuchi
Yoshimi
Y
Yasuoka
Akira
A
Kimura
Satoshi
S
Oka
Shinichi
S
D000208:Acute Disease; D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006506:Hepatitis A / Q000209:etiology*; D030041:Hepatitis A virus / Q000235:genetics / Q000502:physiology*; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012698:Serologic Tests; D019562:Viral Load; D014766:Viremia / Q000821:virology
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase