title: [Comparative study of the efficacy and tolerance of 12% glycolic acid cream and 0.05% retinoic acid cream for polymorphic acne].
abstract: Topical retinoic acid has demonstrated its efficacy in acne. Glycolic acid has also keratolytic action and could be interesting to treat acne.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of topical glycolic acid (Glyco A 12%) and retinoin acid (Kefrane 0.05%) on facial acne lesions.
  
  
  METHODS
  It was a randomised double blind study of 40 patients, divided in 2 groups, 20 receiving GlycoA cream (Group A) and 20 receiving Kefrane cream (group B). Medical exam was realised by the same physician at day 0, 21 and 45. The improvement of acne as well as side effects were assessed by both the physician and the patients themselves.
  
  
  RESULTS
  2 patients developed severe eczema of the face and were excluded (one from group A and one from group B). 22 patients followed totally the study. 90% of group A and 83.3% of group B patients improved significantly their lesions. A comparative tolerability was observed for both groups.
  
  
  CONCLUSIONS
  Glyco A cream could be a good treatment for acne even in dark skin patients.
authors.affiliation: Service de Dermatologie, Hôpital Charles Nicolle, Tunis.
authors.forename: M
authors.initials: M
authors.lastname: Kharfi
authors.forename: N
authors.initials: N
authors.lastname: Tekaya
authors.forename: F
authors.initials: F
authors.lastname: Zeglaoui
authors.forename: N
authors.initials: N
authors.lastname: Ezzine
authors.forename: I
authors.initials: I
authors.lastname: Mokhtar
authors.forename: F
authors.initials: F
authors.lastname: Kamoun
authors.forename: M R
authors.initials: MR
authors.lastname: Kamoun
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000328:Adult; D004485:Eczema / Q000139:chemically induced; D005260:Female; D006016:Glycolates / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D012880:Skin Pigmentation; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D006016:Glycolates; D007641:Keratolytic Agents; C031149:glycolic acid; D014212:Tretinoin
vernacular_title: Etude comparative de l'efficacité et de la tolérance d'une crème a 12% d'acide glycolyque et d'une crème a 0.05% d'acide retinoique dans l'acné polymorphe.