External modulation of airway narrowing.
Compelling evidence has been provided in the last decade that deep inspirations potently attenuate the response to contractile stimuli of normal but not of asthmatic airways. Though it is generally accepted that the modulating effect of deep inspirations on airway narrowing is based on the interdependence between airways and lung parenchyma, the intimate mechanisms are still the object of active research. In this paper, the practical relevance of the reduced ability to dilate airways with deep inspirations will be discussed.
Brusasco
V
V
Cattedra di Fisiopatologia Respiratoria, Dipartimento di Scienze Motorie e Riabilitative, Università di Genova, Italy. brusasco@dism.unige.it
D000402:Airway Obstruction / Q000503:physiopathology*; D001249:Asthma / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis*; D018893:Bronchoalveolar Lavage; D006801:Humans; D012016:Reference Values; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000502:physiology*; D012680:Sensitivity and Specificity