[Effect of hypergravity on the oxidative-antioxidative status of rats].
The adaptogenic and antioxidant properties of new Ukrainian plant drug "Poliphytolum" was investigated on the model of stress, which was caused of hypergravitation 2 and 5 N.m2/kg2 action. It was established that hypergravitation makes typical stressory disturbances in oxidative homeostasis. The normalization action of "Polyphytolum" on lipid peroxidation is more strong in liver, spleen and blood, and less more--in brain. It may be caused of low level the drug in the brain tissue.
Karbashevs'ka
N Ia
NIa
Medical Institute of Ukrainian Assiciation of Folk Medicine, Kiev.
Oliĭnyk
S A
SA
Bilokin'
Iu M
IuM
Baraboĭ
V A
VA
Hrynevych
Iu P
IuP
D000818:Animals; D001921:Brain / Q000502:physiology; D002374:Catalase / Q000097:blood / Q000378:metabolism; D004195:Disease Models, Animal; D018471:Hypergravity / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D013154:Spleen / Q000502:physiology; D013312:Stress, Physiological / Q000188:drug therapy* / Q000209:etiology; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D013858:Thiobarbiturates / Q000097:blood / Q000378:metabolism; D014455:Ukraine
D028321:Plant Preparations; D013858:Thiobarbiturates; D002374:Catalase; D013482:Superoxide Dismutase; C029684:thiobarbituric acid
Okysniuval'no-antyoksydantnyĭ status shchuriv za umov hiperhravitatsiĭ.