Retroperitoneal haematoma after paracetamol increased anticoagulation.
Drugs containing paracetamol are widely used as analgesics but may result in increased anticoagulation in patients who take warfarin, the mechanism being unclear. Retroperitoneal haemorrhage is a serious and well described complication in patients who develop increased anticoagulation; this may result in a femoral neuropathy. Both conservative and surgical treatments have been advocated for this complication.
Andrews
F J
FJ
Accident and Emergency Department, St James's University Hospital, Leeds, UK. fandrews@liv.ac.uk
D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D004357:Drug Synergism; D005260:Female; D020428:Femoral Neuropathy / Q000209:etiology*; D006406:Hematoma / Q000139:chemically induced*; D006801:Humans; D019934:International Normalized Ratio; D008875:Middle Aged; D012187:Retroperitoneal Space; D014859:Warfarin / Q000009:adverse effects / Q000627:therapeutic use
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D014859:Warfarin