title: Inhibitor of beta-hydroxy-beta-methylglutaryl coenzyme A reductase decreases energy supply to the myocardium in rats.
abstract: Hypocholesterolemic preparations, inhibitors of the key enzyme of cholesterol biosynthesis beta-hydroxy-beta-methylglutaryl coenzyme A reductase (statins), block the synthesis of ubiquinone Q10, intermediate electron carrier in the mitochondrial respiratory chain. This should decrease energy supply to tissues. Daily peroral administration of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor simvastatin (24 mg/kg perorally) for 30 days had no effect on the contents of macroergic phosphates (ATP and creatine phosphate) in the liver, but decreased these parameters in the myocardium.
authors.affiliation: Laboratory of Heart Metabolism, Institute of Experimental Cardiology, Moscow.
authors.forename: O I
authors.initials: OI
authors.lastname: Pisarenko
authors.forename: I M
authors.initials: IM
authors.lastname: Studneva
authors.forename: V Z
authors.initials: VZ
authors.lastname: Lankin
authors.forename: G G
authors.initials: GG
authors.lastname: Konovalova
authors.forename: A K
authors.initials: AK
authors.lastname: Tikhaze
authors.forename: V I
authors.initials: VI
authors.lastname: Kaminnaya
authors.forename: Y N
authors.initials: YN
authors.lastname: Belenkov
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003401:Creatine / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010725:Phosphocreatine; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D019821:Simvastatin; D006903:Hydroxymethylglutaryl CoA Reductases; D003401:Creatine