title: Construction and analysis of a human-chimpanzee comparative clone map.
abstract: The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.
authors.affiliation: RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. afujiyam@gsc.riken.go.jp
authors.forename: Asao
authors.initials: A
authors.lastname: Fujiyama
authors.forename: Hidemi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Toyoda
authors.forename: Todd D
authors.initials: TD
authors.lastname: Taylor
authors.forename: Takehiko
authors.initials: T
authors.lastname: Itoh
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Tsai
authors.forename: Hong-Seog
authors.initials: HS
authors.lastname: Park
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Yaspo
authors.forename: Hans
authors.initials: H
authors.lastname: Lehrach
authors.forename: Zhu
authors.initials: Z
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Fu
authors.forename: Naruya
authors.initials: N
authors.lastname: Saitou
authors.forename: Kazutoyo
authors.initials: K
authors.lastname: Osoegawa
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: de Jong
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Suto
authors.forename: Masahira
authors.initials: M
authors.lastname: Hattori
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sakaki
mesh_terms: D000818:Animals; D001483:Base Sequence; D022202:Chromosomes, Artificial, Bacterial; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D003001:Cloning, Molecular; D020451:Contig Mapping; D005260:Female; D015723:Gene Library; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008297:Male; D002679:Pan troglodytes / Q000235:genetics*; D020161:Physical Chromosome Mapping; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D016324:Sequence Tagged Sites; D014960:X Chromosome / Q000235:genetics; D014998:Y Chromosome / Q000235:genetics