title: Splice variants of human beta 1 integrins: origin, biosynthesis and functions.
abstract: The integrin beta1 subfamily of adhesion receptors consists of 12 members and forms the biggest subfamily among integrins. Human integrin subunit beta1 has five cytoplasmic splice variants (beta1A, beta1B, beta1C-1, beta1-C2, beta1D). Even though cytoplasmic splice variants do not change the ligand-specificity of a beta1 integrin, clustering of these different splice variants triggers signaling pathways that lead to a different cellular response. The main focus of this review is on the origin and specific functions of the less abundant human integrin beta1 splice variants (B, C-1, C-2, D).
authors.affiliation: Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, S-751 23, Uppsala, Sweden. Annika.Armulik@cmb.ki.se
authors.forename: Annika
authors.initials: A
authors.lastname: Armulik
mesh_terms: D017398:Alternative Splicing / Q000235:genetics / Q000502:physiology*; D000595:Amino Acid Sequence / Q000235:genetics / Q000502:physiology; D000818:Animals; D001483:Base Sequence / Q000235:genetics / Q000502:physiology; D006801:Humans; D019012:Integrin beta1 / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data
chemical_list: D019012:Integrin beta1