title: Lead poisoning in Indian silver refiners.
abstract: The refining of silver from old silver ornaments, articles and jeweller's waste by smelting these with lead scraps for the fabrication of new jewellery is an important small scale industry in India. The present survey and clinical investigations have shown that 31 out of 50 silver refiners with a mean blood lead level of 32.84+/-1.78 microg/dl (range 20.3-64.9), decrease in blood delta-aminolevulinic acid dehydratase (ALAD) activity and thiamine (as pyruvate) level and an enhanced urinary excretion of ALA as compared to control, were suffering from lead poisoning. Most of these workers have shown anaemia, abdominal colic, blue lining of gum and muscular wasting indicative of lead toxicity. Twenty-four workers with relatively high blood lead levels were equally divided into two groups and given either vitamin B1 (75 mg, once a day) or vitamin C (250 mg. twice a day) for 1 month. The treatment with both the vitamins significantly lowered the blood lead levels and reduced blood thiamine and copper deficiency. In addition, vitamin C was also effective in reversing the inhibition of blood ALAD activity while the effect of vitamin B1 on its activity was marginal. The daily intake of vitamin B1 and vitamin C may prevent the accumulation of lead and reduce its toxic effects particularly in those regularly exposed to lead.
authors.affiliation: Industrial Toxicology Research Centre, Chemical Toxicology, Marg, Lucknow, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Tandon
authors.forename: M
authors.initials: M
authors.lastname: Chatterjee
authors.forename: A
authors.initials: A
authors.lastname: Bhargava
authors.forename: V
authors.initials: V
authors.lastname: Shukla
authors.forename: V
authors.initials: V
authors.lastname: Bihari
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000209:etiology; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D001284:Atrophy; D003085:Colic / Q000209:etiology; D006306:Health Surveys; D006801:Humans; D007194:India / Q000453:epidemiology; D007855:Lead Poisoning / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D000623:Porphobilinogen Synthase / Q000378:metabolism*; D011315:Preventive Medicine; D012834:Silver; D013831:Thiamine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012834:Silver; D000623:Porphobilinogen Synthase; D001205:Ascorbic Acid; D013831:Thiamine