title: Sequence analysis of the rat phenylalanine hydroxylase gene promoter.
abstract: We have characterized the 5'-end (3218 bp) of the rat phenylalanine hydroxylase (PAH) gene. Within this PAH promoter sequence, we have identified a number of putative regulatory sites analogous to those present in the human and murine PAH promoters. In particular, potential HNF 1 binding sites and a CRE have been identified. These sequences respectively bind HNF1 and CREB transcription factors present in rat nuclear extracts and may be significant in the tissue-specific and hormonal control of PAH expression.
authors.affiliation: Department of Biological Sciences, Chester College of Higher Education, Chester, CH1 4BJ, UK.
authors.forename: D
authors.initials: D
authors.lastname: Rees
authors.forename: M J
authors.initials: MJ
authors.lastname: Fisher
authors.forename: I L
authors.initials: IL
authors.lastname: McDowall
mesh_terms: D024506:5' Flanking Region / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D008969:Molecular Sequence Data; D010651:Phenylalanine Hydroxylase / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D051381:Rats / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
chemical_list: D010651:Phenylalanine Hydroxylase