title: Giant cell pneumonia in a leukemic child in remission: a case report.
abstract: Giant cell pneumonia is a rare and uncommon type of lung infection developing as a complication of measles, especially in immunocompromised patients, whether their immune systems are affected primarily or whether they have acquired immune defects. As well as being uncommon, it is also atypical because of absence of the characteristic rash and of absent or low antibody titers against measles in most of the cases. It is known that cellular immunity is more important than humoral immunity in the host response to measles, so hypogammaglobulinemic patients with normal cellular immunity usually recover uneventfully from measles and also have the characteristic rash. We report a case with giant cell pneumonia that was confirmed by postmortem histopathological examination. We especially want to point out that even in the absence of rash, with the clinical and radiological features of pneumonia, measles should be considered in a patient, whether in remission or not, receiving immunosuppressive treatment.
authors.affiliation: Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Kanra
authors.forename: I
authors.initials: I
authors.lastname: Cetin
authors.forename: Z
authors.initials: Z
authors.lastname: Akçören
authors.forename: M
authors.initials: M
authors.lastname: Cağlar
authors.forename: A B
authors.initials: AB
authors.lastname: Cengiz
authors.forename: A
authors.initials: A
authors.lastname: Baykan
authors.forename: A
authors.initials: A
authors.lastname: Kara
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001344:Autopsy; D002648:Child; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D015726:Giant Cells / Q000276:immunology / Q000473:pathology*; D006801:Humans; D016867:Immunocompromised Host; D008457:Measles / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D012074:Remission Induction