title: First direct C-2-Lithiation of 4-DMAP. Convenient access to reactive functional derivatives and ligands.
abstract: The first direct alpha-lithiation of 4-DMAP has been performed via reaction with the BuLi-Me(2)N(CH(2))(2)OLi (BuLi-LiDMAE) reagent. This new methodology avoids the use of a activation-lithiation-regeneration sequence or halogen-metal exchange classically employed. New useful DMAP-containing synthons and polyheterocycles have been efficiently prepared.
authors.affiliation: Synthèse Organique et Réactivité, UMR CNRS-UHP 7565, Faculté des Sciences, Université Henri Poincaré-Nancy I, BP 239, 54506, Vandoeuvre-Lès-Nancy, France.
authors.forename: David
authors.initials: D
authors.lastname: Cuperly
authors.forename: Philippe
authors.initials: P
authors.lastname: Gros
authors.forename: Yves
authors.initials: Y
authors.lastname: Fort
mesh_terms: D008024:Ligands; D008094:Lithium / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C417980:4-(dimethylamine)pyridine; D008024:Ligands; D011725:Pyridines; D008094:Lithium