Spinal tanycytic ependymoma associated with neurofibromatosis type 2--case report.
An 18-year-old girl with a 5-year history of neurofibromatosis type 2, consisting of bilateral acoustic tumors and a meningioma at the planum sphenoidale, presented with an intramedullary mass at the T-1 level, and underwent total removal of the tumor. Histological examination showed that the tumor consisted of markedly elongated spindle-shaped cells, which were immunopositive for S-100 protein and glial fibrillary acidic protein. Ultrastructural examination showed microvilli-lined lumina and prominent intercellular junctions, which were characteristic ependymal features. These findings were compatible with the diagnosis of tanycytic ependymoma. This rare subtype of ependymoma appears to arise through inactivation of NF2, in addition to some typical ependymomas.
Ueki
K
K
Department of Neurosurgery, University of Tokyo Hospital, Tokyo.
Sasaki
T
T
Ishida
T
T
Kirino
T
T
D000293:Adolescent; D000954:Antigens, Surface / Q000032:analysis; D001932:Brain Neoplasms; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D004806:Ependymoma / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging; D016518:Neurofibromatosis 2 / Q000150:complications* / Q000235:genetics; D009418:S100 Proteins / Q000032:analysis; D013120:Spinal Cord Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery
D000954:Antigens, Surface; D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins