title: Accurate, noninvasive detection of Helicobacter pylori DNA from stool samples: potential usefulness for monitoring treatment.
abstract: A novel DNA assay demonstrating sensitive and accurate detection of Helicobacter pylori from stool samples is reported. Moreover, in three individuals tested for therapeutic response, the assay showed the disappearance of H. pylori DNA during treatment. Thus, this noninvasive molecular biology-based assay has the potential to be a powerful diagnostic tool given its ability to specifically identify H. pylori DNA.
authors.affiliation: Applied Research Group, Exact Sciences Corporation, Maynard, Massachusetts 01754, USA.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Shuber
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Ascaño
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Boynton
authors.forename: Anastasia
authors.initials: A
authors.lastname: Mitchell
authors.forename: Henry F
authors.initials: HF
authors.lastname: Frierson
authors.forename: Wa'el
authors.initials: W
authors.lastname: El-Rifai
authors.forename: Steven M
authors.initials: SM
authors.lastname: Powell
mesh_terms: D004269:DNA, Bacterial / Q000032:analysis*; D005243:Feces / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000382:microbiology; D016480:Helicobacter pylori / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D004269:DNA, Bacterial