title: Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.
abstract: Experiments on rats trained passive avoidance task showed that N-phenyl-acetyl-L-prolyl-glycyl ethyl ester, peptide analog of piracetam (GVS-111, Noopept) after oral administration retained antiamnesic activity previously observed after its parenteral administration. Effective doses were 0.5-10 mg/kg. Experiments on a specially-developed model of active avoidance (massive one-session learning schedule) showed that GVS-111 stimulated one-session learning after single administration, while after repeated administration it increased the number of successful learners among those animals who failed after initial training. In this respect, GVS-111 principally differs from its main metabolite cycloprolylglycine and standard nootropic piracetam.
authors.affiliation: Institute of Pharmacology, Russian Academy of Medical Science, Moscow. rita_o@postman.ru
authors.forename: R U
authors.initials: RU
authors.lastname: Ostrovskaya
authors.forename: T K
authors.initials: TK
authors.lastname: Mirsoev
authors.forename: G A
authors.initials: GA
authors.lastname: Romanova
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: E V
authors.initials: EV
authors.lastname: Kravchenko
authors.forename: C C
authors.initials: CC
authors.lastname: Trofimov
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001362:Avoidance Learning; D004151:Dipeptides / Q000008:administration & dosage* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007858:Learning / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D018697:Nootropic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D011392:Proline / Q000737:chemistry*; D051381:Rats
chemical_list: D004151:Dipeptides; D018696:Neuroprotective Agents; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly; D011392:Proline