Ecological and biochemical characteristics of alcohol pathologies in the North and their influence upon the total sickness rate of the population.
Studying different population groups of Yakutia and changes in statistics during the 80-90-s, this paper tries to follow up the tendencies in community differences in tolerance of human organism to alcohol. This paper is also aimed at finding out molecule-genetic reasons for the discovered differences in alcohol tolerance on the basis of research of community phenotype characteristics of isoenzyme spectrum of alcohol reducing enzymes. The paper analyses the influence of alcohol drinking intensity and population steadiness to alcohol upon somatic sickness of the number of nosologic forms and gives an assessment of mechanisms of this influence.
Kershengolts
B
B
Department of Biological chemistry, Yakutsk State University, Republic of Sakha (Yakutia), Russia. bgf_bmk@sitc.ru
Kolosova
O
O
Krivogornizina
E
E
Yakovleva
N
N
Meltser
I
I
D000222:Adaptation, Physiological; D000428:Alcohol Drinking / Q000208:ethnology* / Q000378:metabolism* / Q000503:physiopathology; D000437:Alcoholism / Q000208:ethnology* / Q000378:metabolism* / Q000503:physiopathology; D004361:Drug Tolerance / Q000235:genetics*; D004463:Ecology; D000431:Ethanol / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D044468:Native Hawaiian or Pacific Islander / Q000706:statistics & numerical data*; D010641:Phenotype; D044469:Racial Groups; D012426:Russia / Q000453:epidemiology
D000431:Ethanol