[Role of Wnt signaling and APC protein in the etiology of colorectal cancer].
In this paper we present recent data on molecular function of APC protein and Wnt signaling pathway. Role of a link between APC and Wnt signaling in the etiology of colorectal cancer as well as significance of a mutant APC mice as a model of cancer in man are discussed.
Cebrat
M
M
Zakład Immunologii Nowotworów, Laboratorium Immunologii Komórkowej, Instytutu Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu. cebrat@immuno.iitd.pan.wroc.pl
Strzadała
L
L
D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000378:metabolism*; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000032:analysis; D017491:Genes, APC; D051379:Mice; D008817:Mice, Mutant Strains; D008934:Mitogens / Q000235:genetics / Q000378:metabolism*; D023421:Models, Animal; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D025601:Adenomatous Polyposis Coli Protein; D004273:DNA, Neoplasm; D008934:Mitogens; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins
Rola szlaku sygnałowego Wnt i białka APC w etiologii raka okreznicy.