title: Plasma digoxin concentration in dogs with mitral regurgitation.
abstract: Fifteen and eight mature beagles, without (normal group) and with experimental mitral regurgitation (MR group), respectively, were given 0.02 mg/kg/day digoxin powder for 10 days orally. The optimum time for sample collection after administration of digoxin was observed to be 8-18 hr and 10-22 hr in the normal and MR groups, respectively. In both groups, a stable concentration was reached after 3-5 days of treatment. No differences in plasma level were observed between sexes. The optimum concentration of digoxin was attained at an earlier stage than has been previously reported for both dogs and humans.
authors.affiliation: Tokyo University of Agriculture and Technology, Fuchu, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagashima
authors.forename: H
authors.initials: H
authors.lastname: Hirao
authors.forename: S
authors.initials: S
authors.lastname: Furukawa
authors.forename: K
authors.initials: K
authors.lastname: Hoshi
authors.forename: M
authors.initials: M
authors.lastname: Akahane
authors.forename: R
authors.initials: R
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Yamane
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000097:blood* / Q000627:therapeutic use; D004077:Digoxin / Q000097:blood* / Q000627:therapeutic use; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D006207:Half-Life; D008297:Male; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D012737:Sex Factors; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents; D004077:Digoxin