[Influence of flavonoid of Astragalus membranaceus's stem and leaves on the function of cell mediated immunity in mice].
OBJECTIVE
To investigate the immune regulation of flavonoid of Astragalus membranaceus's stem and leaves (FAM).


METHODS
Changes of total T cell count and subsets in mice were determined by monoclonal antibody assay before and after treatment with FAM, and the LAK activity was tested simultaneously by isotope technique.


RESULTS
FAM could promote the proliferation of lymphocytes induced by ConA, raise the T cell count and regulate the T cell subsets disorder, elevate the LAK activity induced by IL-2.


CONCLUSIONS
FAM possesses the effect of immune stimulation and immune regulation in treating immunosuppressive mice. This study provides the experimental basis for clinical application of FAM.
Jiao
Y
Y
Heilongjiang University of TCM, Harbin (150040).
Wen
J
J
Yu
X
X
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D027883:Astragalus Plant; D027885:Astragalus propinquus; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018520:Plant Shoots / Q000737:chemistry; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C027492:Huang Qi