[Experimental study on multi-infarct dementia treated with reinforcing essence to refresh mental activity method].
OBJECTIVE
To explore the mechanism of multi-infarct dementia (MID) treated with reinforcing essence to refresh mental activity method (RERM).


METHODS
MID rat models were established by injecting sterile dry blood clots into common carotid artery and screening by the first jumping-off latency of diving platform reflex. Effect of RERM on model rats in learning, memory, serum and brain malondialdehyde (MDA), superoxide dismutase (SOD) level, brain monoamine neurotransmitter content, and brain morphosis were observed.


RESULTS
Obvious malfunction of learning and memory was found in MID rat models, and there were also significant decreasing of monoamine neurotransmitters content in partial brain zones, decreasing of SOD activity in brain and increasing of MDA content in serum and brain. RERM could obviously improve learning and memory, raise SOD activity and monoamine neurotransmitters content in brain tissue, lower MDA content in serum and brain of MID rat models, protect brain morphosis of multi-infarction rats.


CONCLUSIONS
RERM might treat MID by restraining lipid peroxidation, improving monoamine neurotransmitters content in partial brain zones and decreasing ischemic damage of brain tissue.
Xu
H
H
Shandong University of TCM, Jinan (250014).
Shao
N
N
Zhang
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism; D015161:Dementia, Multi-Infarct / Q000378:metabolism* / Q000473:pathology; D004298:Dopamine / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood*
D004365:Drugs, Chinese Herbal; D012701:Serotonin; D013482:Superoxide Dismutase; D004298:Dopamine; D009638:Norepinephrine