[Prevention of postoperative scar processes in otorhinolaryngology experimental rationale].
It is shown in vitro that fibroblast proliferation may be inhibited by 5-fluorouracil (5-Fu). In stimulated growth of the fibroblasts the 5-Fu antiproliferative effect takes place even in minimal concentration (2 mcg/ml). Fibroblastic proliferative activity recovers after elimination of 5-Fu from the medium at concentration under 63 mcg/ml.
Kriukov
A I
AI
Sharkov
S M
SM
Shubin
M N
MN
Kalashnikova
E A
EA
Khamzalieva
R B
RB
Akhmedov
Sh M
ShM
D000963:Antimetabolites / Q000494:pharmacology / Q000627:therapeutic use*; D002465:Cell Movement / Q000187:drug effects; D002921:Cicatrix / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control*; D004427:Ear Diseases / Q000601:surgery*; D005347:Fibroblasts / Q000187:drug effects* / Q000473:pathology*; D005472:Fluorouracil / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D013506:Otologic Surgical Procedures / Q000379:methods*; D010254:Paranasal Sinus Diseases / Q000601:surgery*; D011183:Postoperative Complications
D000963:Antimetabolites; D005472:Fluorouracil
Eksperimental'noe obosnovanie profilaktiki posleoperatsionnykh rubtsovykh protsessov v otorinolaringologii.