Monoamine metabolite and catecholamine measurements in cerebrospinal fluid in determining the quality of the pre-operative night's sleep.
Temazepam 20 mg (n = 18), midazolam 15 mg (n = 14), placebo (n = 15) or no medication (n = 20) were given orally as pre-operative hypnotic in healthy patients operated on under spinal analgesia. The quality of the pre-operative night's sleep assessed subjectively was significantly better in patients receiving temazepam (P = < 0.05) and midazolam (P = < 0.05) compared with those receiving no drug. The concentrations of cortisol and monoamine neurotransmitters or their metabolites in cerebrospinal fluid were of no value in monitoring the quality of the pre-operative night's sleep.
Irjala
J
J
Department of Anaesthesiology, Turku Municipal Hospital, Turku, Finland.
Kanto
J
J
Scheinin
M
M
D000328:Adult; D000775:Anesthesia, Spinal; D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid*; D015415:Biomarkers; D002395:Catecholamines / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D008875:Middle Aged; D011300:Preoperative Care; D012890:Sleep / Q000502:physiology*; D013693:Temazepam / Q000627:therapeutic use
D015306:Biogenic Monoamines; D015415:Biomarkers; D002395:Catecholamines; D006993:Hypnotics and Sedatives; D013693:Temazepam; D008874:Midazolam