title: Concurrent left-sided spontaneous pneumothorax in Japanese monogerminal twins.
abstract: Monogerminal twin brothers aged 17 were admitted because of concurrent left-sided spontaneous pneumothorax. A familial background of this common disease in association with the human leukocyte antigen (HLA) has been suggested; however, the actual mode of inheritance in association with HLA typing is still uncertain. HLA analysis in this family revealed the HLA-A24, B61 (40), Cw3, DR4, DR53, and DQ3 haplotype in the twins and their father, who also had a medical history of spontaneous pneumothorax. We report these cases as an extremely rare example of familial occurrence of spontaneous pneumothorax.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tsukadaira
authors.forename: Y
authors.initials: Y
authors.lastname: Okubo
authors.forename: M
authors.initials: M
authors.lastname: Ota
authors.forename: J
authors.initials: J
authors.lastname: Hotta
authors.forename: K
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000293:Adolescent; D004200:Diseases in Twins / Q000235:genetics*; D006680:HLA Antigens / Q000032:analysis*; D006239:Haplotypes; D006801:Humans; D008297:Male; D011030:Pneumothorax / Q000235:genetics* / Q000276:immunology; D014430:Twins, Monozygotic
chemical_list: D006680:HLA Antigens