title: Commercial diet induced hypothyroidism due to high iodine. A histological and radiological analysis.
abstract: A number of puppies of the School Hospital of the Faculty of Veterinary Science-UBA showed bone changes. Measurement of the iodine content of the commercial diet showed a significant increase in its content. Iodine excess causes alterations in thyroid function and morphology, and its hormones have a direct action on bone formation. Three groups of puppies were fed on different diets: a home-prepared diet, a commercial diet (containing 5.6 mg potassium iodide/kg dry food), and a home-prepared diet supplemented with 5.6 mg potassium iodide/kg dry food. Groups B and C developed hypothyroidism. A significant decrease (p<0.05) in the styloid apophyseal surface was found in groups B and C vs. A, determined by radiography. Histologically, the hypertrophied cartilage was shorter in groups B and C than in group A (p<0.0001). The present results suggest that commercial diets with a high iodine content may cause hypothyroidism and changes in bone metabolism.
authors.affiliation: School Hospital-Endocrinology Service, Faculty of Veterinary Science, University of Buenos Aires, Argentina. vcastill@fvet.uba.ar
authors.forename: V A
authors.initials: VA
authors.lastname: Castillo
authors.forename: M A
authors.initials: MA
authors.lastname: Pisarev
authors.forename: J C
authors.initials: JC
authors.lastname: Lalia
authors.forename: M S
authors.initials: MS
authors.lastname: Rodriguez
authors.forename: R L
authors.initials: RL
authors.lastname: Cabrini
authors.forename: G
authors.initials: G
authors.lastname: Márquez
mesh_terms: D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D001842:Bone and Bones / Q000378:metabolism; D002356:Cartilage / Q000473:pathology; D004032:Diet; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D062787:Drug Overdose / Q000662:veterinary; D005552:Forelimb / Q000473:pathology*; D007037:Hypothyroidism / Q000209:etiology / Q000662:veterinary*; D007455:Iodine / Q000009:adverse effects*
chemical_list: D007455:Iodine