Apoptosis induced by picolinic acid-related compounds in HL-60 cells.
We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various picolinic acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells. These results suggest that pyridine substituted with various groups and the consequent change of resonance structure may have an important role in the induction of apoptosis.
Ogata
S
S
Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Japan.
Inoue
K
K
Iwata
K
K
Okumura
K
K
Taguchi
H
H
D017209:Apoptosis / Q000187:drug effects*; D053938:DNA Fragmentation; D005434:Flow Cytometry; D005669:Fusaric Acid / Q000494:pharmacology; D018922:HL-60 Cells / Q000187:drug effects*; D006801:Humans; D010848:Picolinic Acids / Q000494:pharmacology*
D010848:Picolinic Acids; D005669:Fusaric Acid