title: Barostat examination of proximal site of the anastomosis in patients with rectal cancer after low anterior resection.
abstract: Patients who have undergone low anterior resection (LAR) of the rectum for cancer show symptoms of urgency and frequency of defecation after meals. The cause of these symptoms is unclear. It was hypothesized that the functional disorder of the proximal site of the anastomosis after low anterior resection of the rectum often leads to the symptoms and that the 5-HT3 receptor antagonist reduces postprandial colonic contractions. The aim of this study was to assess colon contractions of the proximal site of the anastomosis and the effects of the 5-HT3 receptor antagonist on the contractions. We evaluated 37 patients who had undergone LARs, 17 with high stool frequency (more than four times per day) and 20 with normal stool frequency. In the first part of the study, basal tone, compliance of the proximal site of the anastomosis, and response to a meal (300 kcal) were recorded with a barostat in all patients. In the second part of the study the effects of the 5-HT3 receptor antagonist on contractions of the proximal site of the anastomosis after ingesting a meal was evaluated. Seven healthy controls were also studied for descending colonic tone with a barostat after a meal. Basal barostat balloon volumes showed only small variations in the two post-LAR groups. Compliance of the proximal site of the anastomosis was similar in the two groups. Meal ingestion stimulated contractions of the proximal site of the anastomosis. In patients with high stool frequency the proximal site of the anastomosis contracted earlier than in those with normal stool frequency after a meal. The descending colonic tone of healthy controls did not change after a meal. The 5-HT3 receptor antagonist inhibited postprandial contractions of the proximal site of the anastomosis after LAR. These observations lend support to the idea that gastrocolonic reflex increases in patients who have undergone LAR, leading to high stool frequency. Furthermore, the 5-HT3 receptor antagonist may alleviate the symptoms of urgency and the frequency of defecation.
authors.affiliation: First Department of Surgery, Faculty of Medicine, Gunma University, Maebashi, Japan. emochiki@showa.gunma-u.ac.jp
authors.forename: E
authors.initials: E
authors.lastname: Mochiki
authors.forename: T
authors.initials: T
authors.lastname: Nakabayashi
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Haga
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Asao
authors.forename: H
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000502:physiology; D000704:Analysis of Variance; D000714:Anastomosis, Surgical; D016022:Case-Control Studies; D003672:Defecation; D004435:Eating; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D017829:Granisetron / Q000494:pharmacology; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011312:Pressure; D012004:Rectal Neoplasms / Q000601:surgery*; D012007:Rectum / Q000502:physiology* / Q000601:surgery*; D012702:Serotonin Antagonists / Q000494:pharmacology
chemical_list: D017829:Granisetron; D012702:Serotonin Antagonists