title: Prostate carcinoma with neuroendocrine differentiation: case report and literature review.
abstract: Neuroendocrine differentiation in prostatic carcinomas generally confers a more aggressive clinical behavior and less favorable prognosis than usual prostatic carcinomas. In this manuscript, we report a case of a 58-year-old man with prostatic carcinoma who died 1 year after initial diagnosis. Autopsy showed a disseminated prostatic carcinoma with neuroendocrine differentiation. There were metastasis to the spleen, an organ infrequently involved by disseminated epithelial neoplasms. Neuroendocrine differentiation was demonstrated by immunohistochemical studies in the biopsy and autopsy material.
authors.affiliation: Department of Pathologic Anatomy, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, Brazil.
authors.forename: R C
authors.initials: RC
authors.lastname: Fernandes
authors.forename: M M
authors.initials: MM
authors.lastname: Matsushita
authors.forename: T
authors.initials: T
authors.lastname: Mauad
authors.forename: P H
authors.initials: PH
authors.lastname: Nascimento Saldiva
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology*