Setting occupational exposure limits for sensory irritants: the approach in the European Union.
Beginning in 1990, the European Commission initiated a program to establish European Union (EU)-wide occupational exposure limits (OELs). As in the United States and other countries, a panel of experts known as the Scientific Committee on Occupational Exposure Limits (SCOEL) was identified and brought together to identify the proper values. This article describes the approach used by SCOEL to identify appropriate values for sensory irritants. The EU panel believes that irritant effects in the eyes and respiratory tract can produce symptoms that range from trivial to serious, and that responses to irritants may be viewed as belonging to a continuum. One of the interesting differences between the approach used by the ACGIH TLV committee and the SCOEL is the use of five grades of irritation to evaluate this class of chemicals. For purposes of setting an OEL, the SCOEL makes no distinction between irritation or nuisance and related somatic effects such as headache. How the committee established an OEL for ethyl acetate is offered as an illustrative example.
Meldrum
M
M
D000085:Acetates / Q000009:adverse effects; D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000592:standards*; D005062:European Union; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000503:physiopathology; D007509:Irritants / Q000009:adverse effects / Q000592:standards*; D008452:Maximum Allowable Concentration; D012678:Sensation Disorders / Q000139:chemically induced*
D000085:Acetates; D000395:Air Pollutants, Occupational; D007509:Irritants; C007650:ethyl acetate