title: New measurements for hadrontherapy and space radiation: biology.
abstract: The dual goals of optimizing clinical efficacy of hadrontherapy and determining radiation risk estimates for space research have intersected to a common focus for investigation of the biological effects of charged particles. This paper briefly highlights recent international progress at accelerator facilities engaged in both biological and clinical studies of the effects of particle beams, primarily protons, carbon and iron ions. Basic mechanisms of molecular, cellular and tissue responses continue under investigation for radiations with a range of ionization densities. Late normal tissue effects, including the risk of cancer in particular, are of importance for both research fields. International cooperation has enhanced the rate of progress as evidenced by recent publications. Specific areas of biomedical research related to the biological radiotoxicity of critical organs (especially the central nervous system), individual radiosensitivities to radiation carcinogenesis, and the analysis of effects in mixed radiation fields still require more research. Recommendations for addressing these issues are made.
authors.affiliation: Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Blakely
mesh_terms: D000818:Animals; D015415:Biomarkers; D002244:Carbon; D002468:Cell Physiological Phenomena / Q000528:radiation effects; D003359:Cosmic Radiation; D004307:Dose-Response Relationship, Radiation; D020450:Heavy Ions; D006801:Humans; D007501:Iron; D009381:Neoplasms, Radiation-Induced; D011522:Protons; D011853:Radiobiology; D011878:Radiotherapy; D015398:Signal Transduction / Q000528:radiation effects; D013026:Space Flight
chemical_list: D015415:Biomarkers; D011522:Protons; D002244:Carbon; D007501:Iron