[Effect of three composite recipes on content of monoamine transmitters in hypothalamus induced by intracerebroventricular injection of interleukin-1 of rats].
OBJECTIVE
To explore the different effects of Youguiyin decoction, Sijunzi decoction, Taohong Siwu decoction on the content of monoamine transmitters in the hypothalamus induced by cytokines.


METHODS
A reactive status of hypothalamic monoamine transmitters to cytokine in rat was built by observing the content change of monoamine transmitters in hypothalamic homogenate after intracerebroventricular (icv) injection of human recombinant interleukin-1 beta(IL-1 beta). On this basis, the different effect of three composite recipes on this status was observed.


RESULTS
The content of norepinephrine (NE) declined significantly compared with control group after icv injection of IL-1. Compared with IL-1 group, Youguiyin further reduced the content of NE induced by icv injection of IL-1, while Taohong Siwu decoction and Sijunzi decoction did not show any effect on this status.


CONCLUSIONS
It seems that Youguiyin for tonifying Kidney could increase the reactivity of hypothalamic NE neuron, Sijunzi decoction for invigorating Spleen and Taohong Siwu decoction for promoting blood circulation did not show this effect.
Duan
Y
Y
Institute of Integrated Traditional and Western Medicine, Shanghai Medical University, Shanghai (200040).
Zhang
X
X
Shen
Z
Z
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism*; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology
D015306:Biogenic Monoamines; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007375:Interleukin-1; D011994:Recombinant Proteins; D009638:Norepinephrine