A new drug delivery system using plasma-irradiated pharmaceutical aids. VIII. Delayed-release of theophylline from double-compressed tablet composed of eudragit as wall material.
The rapid release from a double-compressed tablet containing theophylline as a core drug with the pH-dependent water-soluble polymers, Eudragit L100, S100 or L100-55 used as a wall material was suppressed by argon plasma-irradiation due to an effect of inter-segmental cross-link reactions on the decrease in the surface polymer solubility of outer layer. In addition, the rapid theophylline release from the double-compressed tablet of Eudragit L100-55 with a lower glass transition temperature (Tg) has converted into the delayed-release system under a set of plasma operational conditions due to an additional effect of plasma heat flux on softening of Eudragit L100-55 surface resulting in the formation of the film-like surface with a particle-particle interlinking of the outer layer.
Kuzuya
M
M
Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Japan. kuzuya@gifu-pu.ac.jp
Ito
K
K
Kondo
S
S
Makita
Y
Y
D003692:Delayed-Action Preparations; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006358:Hot Temperature; D008855:Microscopy, Electron, Scanning; D010592:Pharmaceutic Aids; D011109:Polymethacrylic Acids / Q000737:chemistry; D011312:Pressure; D012995:Solubility; D013499:Surface Properties; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects
D003692:Delayed-Action Preparations; D010592:Pharmaceutic Aids; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D013806:Theophylline