title: Spontaneous bacterial peritonitis caused by quinolone-resistant Escherichia coli: could steroid therapy play a role?
abstract: Prophylaxis with norfloxacin has been shown to be effective in preventing spontaneous bacterial peritonitis (SBP) in liver cirrhosis. This therapy is associated with the appearance of quinolone-resistant Escherichia coli. However, only four cases of SBP caused by quinolone-resistant E. coli have been reported so far. We present four cases of quinolone-resistant E. coli SBP in three patients receiving oral quinolones, and who were on corticosteroid therapy to treat associated disorders.
authors.affiliation: Liver Unit, Department of Internal Medicine, Hospital General Universitari Vall d'Hebron, Barcelona, Spain. cereto@hg.vhebron.es
authors.forename: Ferran
authors.initials: F
authors.lastname: Cereto
authors.forename: Joan
authors.initials: J
authors.lastname: Genescà
authors.forename: Alex
authors.initials: A
authors.lastname: Smithson
authors.forename: Antonio
authors.initials: A
authors.lastname: González
authors.forename: Gina
authors.initials: G
authors.lastname: Moreno
authors.forename: Oscar
authors.initials: O
authors.lastname: del Valle Ortiz
authors.forename: Rafael
authors.initials: R
authors.lastname: Esteban
authors.forename: Jaime
authors.initials: J
authors.lastname: Guardia
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000175:diagnosis* / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000494:pharmacology / Q000627:therapeutic use; D010538:Peritonitis / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control*; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D005938:Glucocorticoids; D009643:Norfloxacin; D011241:Prednisone