title: [Prophylactic efficacy of aerosol preparations based on Abies siberica polyprenols in experimental influenza infection].
abstract: Preliminary investigations showed high preventive activity of two of three aerosol preparations of Abies sibirica polyprenols with nonionic surface active substances towards influenza infection. At least 2 aerosol administrations are needed to attain a high protective effect, the second dose depending on the first. Relationship between animal reaction to influenza virus infection changed in a nonmonotonous mode, depending on the drug dose injected during the first treatment: as the dose increased, the death rate first decreased and reached the minimum and then increased again. Such a reaction to aerosol treatment can be explained by the hypothesis of hyperstimulation followed by exhaustion of the host defense systems after high doses of the preparation.
authors.forename: A N
authors.initials: AN
authors.lastname: Sergeev
authors.forename: A S
authors.initials: AS
authors.lastname: Safatov
authors.forename: O V
authors.initials: OV
authors.lastname: P'iankov
authors.forename: L E
authors.initials: LE
authors.lastname: Bulychev
authors.forename: V A
authors.initials: VA
authors.lastname: Zhukov
authors.forename: A G
authors.initials: AG
authors.lastname: Alekseeva
authors.forename: V A
authors.initials: VA
authors.lastname: Petrishchenko
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: V D
authors.initials: VD
authors.lastname: Poryvaev
authors.forename: A G
authors.initials: AG
authors.lastname: Glotov
mesh_terms: D000336:Aerosols; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D045782:Hemiterpenes; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D000439:Pentanols / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D028201:Pinaceae / Q000737:chemistry*
chemical_list: D000336:Aerosols; D000998:Antiviral Agents; D045782:Hemiterpenes; D000439:Pentanols; C009034:prenol
vernacular_title: Profilakticheskaia éffektivnost' aérozoleĭ preparatov na osnove poliprenolov pikhty sibirskoĭ pri éksperimental'noĭ grippoznoĭ infektsii.