Non-Hodgkin lymphoma of the endometrium in human immunodeficiency virus infection.
BACKGROUND
Non-Hodgkin lymphoma has become a common malignancy in patients infected with the human immunodeficiency virus (HIV), being classified as an acquired immunodeficiency syndrome-defining malignancy. The female genital tract is involved usually with non-Hodgkin lymphoma as part of disseminated disease. It is extremely rare for this tumor to originate in the female reproductive tract, especially in the endometrium.


METHODS
An HIV-positive woman underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy for intractable menometorrhagia and resultant anemia thought to be secondary to uterine leiomyoma. The histologic diagnosis was high-grade, immunoblastic, non-Hodgkin lymphoma with plasmacytoid features originating in the endometrium.


CONCLUSIONS
This unusual presentation obligates the clinician to include non-Hodgkin lymphoma in the differential diagnosis when evaluating HIV-positive patients with abnormal uterine bleeding that cannot be explained after thorough evaluation.
Gates
E J
EJ
Department of Obstetrics and Gynecology, State University of New York Health Science Center at Brooklyn, USA.
Diaz-Arrastia
C
C
DiMaio
T
T
Maiman
M A
MA
D000328:Adult; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000150:complications* / Q000601:surgery; D008595:Menorrhagia / Q000175:diagnosis / Q000209:etiology*