[A study of histopathology and cell proliferation in calcifying odontogenic cyst].
OBJECTIVE
To investigate the histopathologic and clinical characteristics and proliferative activities of calcifying odontogenic cyst (COC).


METHODS
25 cases of COC were reviewed. The expression of proliferating cell nuclear antigen (PCNA) was studied using avidin-biotin peroxidase method and the number of nuclear organizing regions was calculated by means of the argyrophil staining technique in these cases.


RESULTS
The cases were divided into 13 (52%) cysts and 12 (48%) neoplasms. Of the 12 neoplasms, 4 were odontogenic ghost cell carcinoma, with a PCNA labelling index (65.9% +/- 7.3%) significantly higher than that of benign neoplastic variant (45.8% +/- 11.5%, P < 0.05) and cystic variant (29.3% +/- 11.2%, P < 0.01). The AgNOR counts was higher in the carcinomatous than benign or cystic variant.


CONCLUSIONS
The lesions show considerable diversity in structure and behavior. It is therefore proposed that quantiation of staining for NOR-associated proteins and the PCNA labelling index are diagnostically useful in COC.
Lei
A
A
Department of Stomatology, Wuhan Second Municipal Hospital, Wuhan 430014.
Wang
S
S
Su
Q
Q
D002455:Cell Division; D006801:Humans; D007573:Jaw Neoplasms / Q000473:pathology*; D018333:Odontogenic Cyst, Calcifying / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis
D018809:Proliferating Cell Nuclear Antigen