title: Mitochondrial calcium in heart cells: beat-to-beat oscillations or slow integration of cytosolic transients?
abstract: Mitochondria have been implicated in intracellular Ca2+ signaling in many cell types. The inner mitochondrial membrane contains Ca2+-transporting proteins, which catalyze Ca2+ uptake and extrusion. Intramitochondrial (matrix) Ca2+, in turn, regulates the activity of Krebs cycle dehydrogenases and, ultimately, the rate of ATP synthesis. In the myocardium, controversy remains whether the fast cytosolic Ca2+ transients underlying excitation-contraction coupling in beating cells are rapidly transmitted into the matrix compartment or slowly integrated by the mitochondrial Ca2+ transporters. This mini-review critically summarizes the recent experimental work in this field.
authors.affiliation: Loyola University Chicago, Stritch School of Medicine, Dept of Physiology, Maywood, Illinois 60153, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hüser
authors.forename: L A
authors.initials: LA
authors.lastname: Blatter
authors.forename: S S
authors.initials: SS
authors.lastname: Sheu
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D002952:Citric Acid Cycle; D003600:Cytosol / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006339:Heart Rate; D007700:Kinetics; D008929:Mitochondria, Heart / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D009991:Oscillometry
chemical_list: D000255:Adenosine Triphosphate; D002118:Calcium