title: Biochemical and ultrastructural alterations in rat after hyperoxic treatment: effect of taurine and hypotaurine.
abstract: The cell ultrastructure and some detoxifying enzyme activities were studied in skeletal muscles of young rats kept for 84 h under normobaric hyperoxia (95% O2) or normoxia as control. Rat were injected i.p.. Every 12 h either with 1 ml saline, 1 ml saline+30 mg hypotaurine or 1 ml saline+30 mg taurine. Ultrastructural observation revealed an highly protective effect on tissue damages due to hyperoxia in taurine-treated rats and, at less extent, in hypotaurine-treated ones. Enzymatic assays suggest a different mechanism of the two molecules in their protective action.
authors.affiliation: Dipartimento di Biologia di Base ed Applicata, Università di L'Aquila, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pitari
authors.forename: S
authors.initials: S
authors.lastname: Duprè
authors.forename: A M
authors.initials: AM
authors.lastname: Ragnelli
authors.forename: P
authors.initials: P
authors.lastname: Aimola
authors.forename: C
authors.initials: C
authors.lastname: Di Giulio
authors.forename: F
authors.initials: F
authors.lastname: Amicarelli
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D018496:Hyperoxia / Q000201:enzymology*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D013654:Taurine; C003949:hypotaurine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase