title: A simple biomimetic synthesis of styelsamine B.
abstract: An extremely rapid, low cost, and environmentally friendly entry into the pyridoacridine family of alkaloids has been devised, as demonstrated here by the first total synthesis of styelsamine B (3) and its oxidation to the quinoneimine cystodytin J (4). The known reaction of cystodytin J with methanethiol makes this a formal synthesis of diplamine. [reaction: see text]
authors.affiliation: Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720, USA.
authors.forename: D
authors.initials: D
authors.lastname: Skyler
authors.forename: C H
authors.initials: CH
authors.lastname: Heathcock
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D018716:Molecular Mimicry; D015394:Molecular Structure; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000470:Alkaloids; D011809:Quinones; C445722:styelsamine B