[Physiopathology of eczema].
Eczema is a skin inflammatory reaction mediated by antigen-specific T cells. Two main disorders belong to this group: contact dermatitis and atopic dermatitis. The pathophysiological mecanisms involved in both disorders are similar and include, at the cellular level, three elements: the antigen (hapten or environmental antigen), antigen-presenting cells belonging to the group of dendritic cells and antigen-specific T cells. The Langerhans cell responsible for antigen handling and presentation to specific T cells appears to play a central role for the generation of the inflammatory reaction.
Krasteva
M
M
Immunologie clinique et transplantation INSERM U 80 Faculté de médecine Lyon-Laennec 69372 Lyon.
Choquet
G
G
Descotes
J
J
Nicolas
J F
JF
D000938:Antigen-Presenting Cells / Q000276:immunology; D003876:Dermatitis, Atopic / Q000150:complications / Q000276:immunology; D003877:Dermatitis, Contact / Q000150:complications / Q000276:immunology; D004485:Eczema / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000150:complications / Q000276:immunology; D007249:Inflammation; D007801:Langerhans Cells / Q000276:immunology; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology
Physiopathologie de l'eczéma.