The dual association between lymphoma and autoimmunity.
Autoimmune rheumatic diseases and lymphocytic malignancies are related and this association is bidirectional. Lymphomas occur more frequently in the course of autoimmune disease and autoimmune rheumatic manifestations occur in the course of lymphocytic malignancies. An increased incidence of malignant lymphocytic diseases is present in patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and autoimmune thyroid disease. Descriptions of lymphocytic malignancies among other autoimmune rheumatic disease have been published. In some patients, the malignant disease is diagnosed months or years before the appearance of the rheumatic disease.
Ehrenfeld
M
M
Research Centre for Autoimmune Diseases, Sheba Medical Centre, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Abu-Shakra
M
M
Buskila
D
D
Shoenfeld
Y
Y
D000951:Antigens, Neoplasm / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications* / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D001379:Azathioprine / Q000009:adverse effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000276:immunology; D015331:Cohort Studies; D015897:Comorbidity; D004198:Disease Susceptibility; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000453:epidemiology; D008223:Lymphoma / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000276:immunology; D011446:Prospective Studies; D012189:Retrospective Studies; D012306:Risk; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D014657:Vasculitis / Q000150:complications / Q000453:epidemiology
D000951:Antigens, Neoplasm; D001323:Autoantibodies; D001324:Autoantigens; D006680:HLA Antigens; D007166:Immunosuppressive Agents; D001379:Azathioprine