title: [Histomorphologic study of the bone repair materials by using the cold plasma technique].
abstract: OBJECTIVE
  The purpose of this article is to improve the biological activity of the implant pretreated by use of cold plasma technic and to investigate the biological effects after implanted into bone.
  
  
  METHODS
  First, HA granular was set in the electric field with high voltage and vacuum, then the gaseous mixture of ammonia, hydrogen and nitrogen was led to. By coupled capacity glow discharge, the plasma was produced and the pretreatment was completed. In this way, the surface of HA granular may obtain active amino structure. Sequently, the material was implanted into bone of the animal and the dynamic changes at the material/bone interface were histologically observed.
  
  
  RESULTS
  The active group was definitely formed on the surface of the material after pretreatment and there were no adverse effects on the morphology and properties of the base material. Furthermore, the early formation of new bone at the interface of the material/bone was detected, and obvious effects on facilitating bone growth and osseointegration were obtained.
  
  
  CONCLUSIONS
  The findings indicated that cold plasma pretreatment technic was an effective method to improve the biological activity of implant material.
authors.affiliation: College of Stomatology, West China University of Medical Sciences, Chengdu 610041.
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Qiu
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D015921:Dental Implants; D003764:Dental Materials; D004285:Dogs
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; D003764:Dental Materials