[Biomechanical experimental study on effective fraction of radix salviae miltiorrhizae on healing of bone fracture].
OBJECTIVE
To assess the effect of Danshen-9403 (DS-9403, an effective fraction of Radix Salviae Miltiorrhizae) on healing of bone fracture.


METHODS
Standardized radial fracture was performed in 120 Wistar rats. The model animals were randomized into four groups: group A was fed with DS-9403, group B injected with Staphylococcus Aureus, group C with normal saline, and group D with Salviae injection. The treatment began at the first day of fracture. The rats were sacrificed on the 25th, 39th and 50th day separately in batches and their intact radii were removed by dissection for detecting load and stress of three-point bending test with autograph universal material testing machine (Shimazu, Japan).


RESULTS
The parameters of load in DS-9403 treated groups on the 39th day and that of stress at 25th, 39th and 50th day were (6.20 +/- 1.32) N, (5.71 +/- 3.58) N/mm2, (8.27 +/- 2.42) N/mm2 and (66.25 +/- 26.21) N/mm2 respectively, which were significantly higher than those in other groups, P < 0.05.


CONCLUSIONS
DS-9403 has the action of increasing the strength of fracture healing site.
Fu
S
S
Department of Traumatology, Ruijin Hospital, Shanghai Second Medical University, Shanghai (200025).
Du
N
N
Shi
W
W
D000818:Animals; D001696:Biomechanical Phenomena; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D017102:Fracture Healing / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts; D011885:Radius Fractures / Q000503:physiopathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza; D014665:Vasodilator Agents / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D014665:Vasodilator Agents