title: Chromium vinylidene carbenoids: stereospecific synthesis of (Z)-2-chloroalk-2-en-1-ols.
abstract: (Z)-2-Chloroalk-2-en-1-ols are obtained in excellent yields from a wide variety of aldehydes by addition of (E)-chromium vinylidene carbenoids, stereospecifically generated from trichloroalkanes using CrCl(2) in THF at room temperature. [reaction: see text]
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.
authors.forename: D K
authors.initials: DK
authors.lastname: Barma
authors.forename: R
authors.initials: R
authors.lastname: Baati
authors.forename: A
authors.initials: A
authors.lastname: Valleix
authors.forename: C
authors.initials: C
authors.lastname: Mioskowski
authors.forename: J R
authors.initials: JR
authors.lastname: Falck
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002857:Chromium / Q000737:chemistry*; D006838:Hydrocarbons; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000438:Alcohols; D006838:Hydrocarbons; D014753:Vinyl Compounds; D002857:Chromium; C030011:carbene; D008697:Methane