Prostaglandin biology.
PGs are important mediators of normal physiology, response to injury, and pathologic processes. Dissecting these biochemical and molecular pathways allows development of therapeutic agents that can be [figure: see text] applied to specific clinical situations, while preserving PGs that play a role in normal physiology.
Crofford
L J
LJ
Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA. crofford@umich.edu
D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D015870:Gene Expression; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins; D010740:Phospholipases / Q000145:classification / Q000378:metabolism*; D044262:Prostaglandin H2; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis / Q000145:classification / Q000378:metabolism*; D011463:Prostaglandins H / Q000378:metabolism*; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D007527:Isoenzymes; D008565:Membrane Proteins; D011453:Prostaglandins; D011463:Prostaglandins H; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D011982:Receptors, Prostaglandin; D014157:Transcription Factors; D044262:Prostaglandin H2; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D010740:Phospholipases