[Effects of ovulation induction therapies on endometrial integrin alpha v beta 3 expression in patients with polycystic ovarian syndrome related infertility].
OBJECTIVE
To study the endometrial integrins alpha v beta 3 expressions during mid-luteal(ML) phase in polycystic ovarian syndrome (PCOS) related infertile patients receiving ovulation induction therapies.


METHODS
Immunohistochemical methods using monoclonal antibody against integrins alpha v beta 3 were performed on endometrium of ML phase obtained from 22 normal subjects and 40 PCOS related anovulatory patients who underwent ovulation induction therapy by one of the following regimens: clomiphene citrate (CC) + human chorionicgonadotropin (hCG), CC + human menopausal gonadotropin (hMG) + hCG, or gonadotropin-releasing hormone agonist + hMG + hCG.


RESULTS
The expressions of endometrial integrin alpha v beta 3 during ML phase in GnRHa + hMG + hMG + hCG cycles were similar with those in normal natural cycles, but were weaker in CC + hCG, CC + hMG + hCG cycles as compared with controls.


CONCLUSIONS
CC + hCG, CC + hMG + hCG regimens may induce decline of endometrial receptivity in ML phase.
Wang
Y
Y
Department of Obstetrics and Gynecology, Third Clinical Hospital, Beijing Medical University, Beijing 100083, China.
Chen
Y
Y
Li
M
M
D000328:Adult; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004717:Endometrium / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D019030:Receptors, Vitronectin / Q000032:analysis*
D006063:Chorionic Gonadotropin; D019030:Receptors, Vitronectin