Inhaled nitric oxide in cardiology.
Inhaled nitric oxide (INO) allows selective pulmonary vasodilatation with rapidity of action. It is effective in the acute management of reversible pulmonary hypertension in cardiac medical and surgical patients and is also useful in assessing the pulmonary vasodilator capacity in patients with chronic pulmonary hypertension. This review will examine the role of INO in the management of cardiac patients, compared to alternatives where available. The use of INO in cardiac failure, post-operative cardiac patients, patients with congestive cardiac failure or congenital heart disease will also be reviewed. Newer alternatives with prolonged pulmonary activity and simpler administration are also discussed.
Hayward
C S
CS
Heart Failure and Transplant Unit, St Vincent's Hospital, Victoria St, Darlinghurst, NSW 2010, Australia. chayward@stvincents.com.au
Macdonald
P S
PS
Keogh
A M
AM
D000280:Administration, Inhalation; D000818:Animals; D006348:Cardiac Surgical Procedures; D004730:Endothelium, Vascular / Q000473:pathology; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D007431:Intraoperative Complications / Q000188:drug therapy; D009569:Nitric Oxide / Q000008:administration & dosage / Q000009:adverse effects / Q000502:physiology / Q000627:therapeutic use*; D011182:Postoperative Care; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use
D014665:Vasodilator Agents; D009569:Nitric Oxide