[The correlation between P-glycoprotein and multidrug resistance of squamous carcinoma in oral and maxillofacial region].
OBJECTIVE
To study the mechanism of drug resistance of oral carcinoma to chemotherapy.


METHODS
40 cases of squamous carcinoma in the oral and maxillofacial region were examined for the multidrug resistance gene product P-glycoprotein using a monoclonal antibody MRK16.


RESULTS
P-glycoprotein was detected in 62.5% of the sample. P-glycoprotein expression was related to the chemotherapy and the degree of differentiation. P-glycoprotein expression was higher in post-chemotherapy group than in unchemotherapy group (P < 0.05). Well differentiated tumors expressed P-glycoprotein more frequently (P < 0.05). P-glycoprotein expression was compared with clinic response to chemotherapy. The accuracy rate of prediction is 75%.


CONCLUSIONS
P-glycoprotein plays an important role in mechanism of multidrug resistance of squamous carcinoma in the oral and maxillofacial region.
Xie
Z
Z
Department of Stomatology, First Teaching Hospital, Zhejiang University, Hangzhou 310003.
Gu
Z
Z
Wu
Q
Q
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis*; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1