title: The evolution of the MHC-G gene does not support a functional role for the complete protein.
abstract: The study of the MHC-G gene evolution during nearly 40 million years does not support a role for the full molecule. The MHC-G-like proteins of New World monkeys are probably classical presenting molecules. Old World Cercopithecinae monkeys do not have a full MHC-G molecule and human individuals homozygous for the HLA-G null allele are healthy and do not show birth pathologies.
authors.affiliation: Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain. aarnaiz@eucmax.sim.ucm.es
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
authors.forename: J
authors.initials: J
authors.lastname: Martinez-Laso
authors.forename: M J
authors.initials: MJ
authors.lastname: Castro
authors.forename: P
authors.initials: P
authors.lastname: Morales
authors.forename: J
authors.initials: J
authors.lastname: Moscoso
authors.forename: P
authors.initials: P
authors.lastname: Varela
authors.forename: E
authors.initials: E
authors.lastname: Gomez-Casado
authors.forename: L M
authors.initials: LM
authors.lastname: Allende
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002427:Cebidae / Q000235:genetics; D002520:Cercopithecidae / Q000235:genetics; D019143:Evolution, Molecular; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000737:chemistry / Q000502:physiology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I