title: [Analysis of HLA-DR in Mexican patients with pemphigus].
abstract: Pemphigus are a group of bullous skin disorders histologically characterized by intraepidermal acantholytic and circulating antibodies blisters due to directed against the cellular surface of keratinocytes. In Mexican patients with pemphigus, HLA antigens have not been studied as they have been for other populations; for this reason, a comparative, prospective, transversal and observational study has been done with 25 patients, 18 with pemphigus vulgaris and the other seven with pemphigus foliaceus. DNA was extracted by the salting-out method and HLA-DR was determined by amplification with PCR and allele-specific oligonucleotides (ASO).
  
  
  RESULTS
  HLA-DR14 (DR6) is more common in patients with pemphigus vulgaris than in the healthy population, which corroborates with previous reports. On the other hand, as reported we also found that HLA-DR1 in Mexican population represents a higher risk for pemphigus foliaceus.
authors.affiliation: Departamento de Dermatología del Hospital General Dr. Manuel Gea González, Tlalpan 4800, Col. Toriello Guerra, 14000, Tlalpan México, D.F.
authors.forename: M E
authors.initials: ME
authors.lastname: Vega-Memije
authors.forename: M M
authors.initials: MM
authors.lastname: Sáez de Ocariz-Gutiérrez
authors.forename: R
authors.initials: R
authors.lastname: Cortés-Franco
authors.forename: L
authors.initials: L
authors.lastname: Domínguez-Soto
authors.forename: J
authors.initials: J
authors.lastname: Granados-Arriola
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010392:Pemphigus / Q000097:blood*; D011446:Prospective Studies
chemical_list: D006684:HLA-DR Antigens
vernacular_title: Análisis de HLA-DR en pacientes mexicanos con pénfigo.