title: Mixed cobalt(III) complexes with aromatic amino acids and diamine. Part II. Synthesis and configuration of (1,2-diaminoethane)bis(L-tyrosinato)cobalt(III)complex diastereomers. The crystal structure of the delta-C1-cis(O) diastereomer.
abstract: In the reaction of trans-[CoCl2(en)2]+ with L-tyrosine all six theoretically possible diastereomers of the (1,2-diaminoethane)bis(L-tyrosinato)cobalt(III) complex were formed. The following five were isolated: gamma-trans(O); and gamma- and delta-C2-cis(O) and gamma- and delta-C1-cis(O) diastereomers, while the delta-trans(O) diastereomer was only detected in the corresponding eluate. Separation of the obtained diastereomers was performed by chromatography on a Dowex 1 x 4 column. Characterization of the isolated diastereomers was carried out by means of elemental analysis, electronic absorption, circular dichroic, 1H and 13C NMR spectra, and by x-ray crystal structure analysis in the case of the delta-C1-cis(O) diastereomer. We established the general rule of preference of diasteromers formation in complexes of [Co(L-aa)2diamine]+ (L-aa = L-amino acid anion; diamine = 1,2-diaminoethane or 1,3-diaminopropane) type.
authors.affiliation: Faculty of Chemistry, University of Belgrade, Yugoslavia. dmiodrag@chem.bg.ac.yu
authors.forename: D U
authors.initials: DU
authors.lastname: Miodragović
authors.forename: G A
authors.initials: GA
authors.lastname: Bogdanović
authors.forename: S M
authors.initials: SM
authors.lastname: Milosavljević
authors.forename: M J
authors.initials: MJ
authors.lastname: Malinar
authors.forename: M B
authors.initials: MB
authors.lastname: Celap
authors.forename: A
authors.initials: A
authors.lastname: Spasojević-de Biré
authors.forename: S
authors.initials: S
authors.lastname: Macura
authors.forename: N
authors.initials: N
authors.lastname: Juranić