Intralesional injection for hepatic metastasis from cervical carcinoma. A report of two cases.
BACKGROUND
The treatment of isolated hepatic metastasis from carcinoma of the uterine cervix has yet to be established. We tested the efficacy of percutaneous injection of ethanol and acetic acid as a curative-intent treatment modality for this rare event.


METHODS
Under real-time sonographic guidance, two patients with a solitary hepatic metastasis from carcinoma of the cervix were treated with 99.5% percutaneous ethanol injection (one patient) and 50% percutaneous acetic acid injection (the other patient). The treatment was repeated weekly if laboratory data permitted and aspiration cytology interpreted on site showed tumor cells. Cytology after complete treatment showed no residual tumor cells in either case. Both patients had no evidence of disease during follow-up for 12 and 24 months, respectively.


CONCLUSIONS
Treatment was successful in two patients with isolated hepatic metastatic lesions from carcinoma of the cervix who received percutaneous injection of 99.5% ethanol or 50% acetic acid.
Chao
A
A
Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Lai
C H
CH
Hsueh
S
S
Lin
S M
SM
Chang
T C
TC
D019342:Acetic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D000431:Ethanol / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007202:Indicators and Reagents / Q000008:administration & dosage* / Q000627:therapeutic use; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D012997:Solvents / Q000008:administration & dosage* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D007202:Indicators and Reagents; D012997:Solvents; D000431:Ethanol; D019342:Acetic Acid