[Study on expression of apoptosis related genes in non-small cell carcinoma].
OBJECTIVE
To study the relationship between the expression of apoptosis related genes in the tissue of non-small cell lung carcinoma (NSCLC) and clinicopathology in the tumor.


METHODS
The expression of bcl-2, bax, Fas and FasL were detected with immunohistochemistry method in 45 cases of NSCLC.


RESULTS
23 (51%) cases of NSCLC were bcl-2 positive, 38 (84%) were bax positive (P < 0.01), and there was no significant correlation between the expression of bcl-2 and bax protein, but a positive relationship was found between the expression of Fas and FasL (P < 0.01). The positive rate of bcl-2 expression decreased in advanced stages of NSCLC(P < 0.05), the bax expression was lower in cases with poor cell differentiation (P < 0.05), and the FasL expression was higher in adenocarcinoma (P < 0.01). The simultaneous expression of bcl-2 and bax protein was closely correlated with TNM stages (P < 0.05), the differences of bcl-2 protein expression alone in NSCLC with cell differentiation were statistically significant (P = 0.033).


CONCLUSIONS
Both bcl-2, bax, Fas and FasL may involve in the regulation of apoptosis and may play an important role in the occurrence and progression of NSCLC.
Wei
W
W
Department of Respiratory Medicine, Affiliated Hospital of Yanbian University College of Medicine, Yanji 133000.
Yin
X
X
Jin
H
H
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism*; D053222:Fas Ligand Protein; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000235:genetics; D051028:bcl-2-Associated X Protein; D019014:fas Receptor / Q000096:biosynthesis / Q000235:genetics
C494826:BAX protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D019014:fas Receptor