[Effect of xinmaitong capsule on total ischemia burden in coronary heart disease patients with myocardial ischemia and analysis of its therapeutical mechanism].
OBJECTIVE
To assess the effect of Xinmaitong (XMT) capsule in treating ischemical cardiac disease.


METHODS
Sixty coronary heart disease (CHD) patients with myocardial ischemia were divided randomly into two groups. XMT group (30 cases) was treated with XMT plus western medicine, and control group (30 cases) with western medicine alone. The changes of the scores for clinical symptoms, the total ischemia burden (TIB), the plasma endothelin (ET), the nitric oxide (NO), the superoxide dismutase (SOD), and the malonyldialdeyde (MDA) levels were observed before and after treatment.


RESULTS
After treatment with XMT the scores of clinical symptoms, TIB, ET and MDA levels were significantly decreased (P < 0.01), the levels of NO and SOD were significantly increased (P < 0.01) in the XMT group, comparing with the control group these changes were statistically different (P < 0.01).


CONCLUSIONS
XMT capsule can act against myocardial ischemia effectively, one of the mechanisms of which is protecting the function of vascular endothelium and resisting lipid peroxidation injury. The effects of adding XMT capsule on conventional treatment of western medicine were better than those of using western medicine alone.
Qiu
R
R
First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou (510080).
He
J
J
Lan
J
J
D000368:Aged; D002214:Capsules; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy*; D009569:Nitric Oxide / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood
D002214:Capsules; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D009569:Nitric Oxide; D013482:Superoxide Dismutase