[The study on human leucocyte antigen DQ region genes polymorphism in unexplained habitual abortion patients].
OBJECTIVE
To investigate whether human leucocyte antigen DQ (HLA-DQ) genes polymorphism are related to the susceptibility to unexplained habitual abortion.


METHODS
HLA-DQA1 and HLA-DQB1 gene typings are performed by polymerase chain reaction-restrictive fragment length polymorphism(PCR-RFLP) technique in 32 cases of unexplained habitual abortion and 54 women with normal pregnancy history.


RESULTS
In unexplained habitual abortion group, the frequency of DQB1 * 0604, 0605 allele is increased significantly compared with that of controls(12.5% and 2.8%, P < 0.05) and the frequency of DQB1 * 0501, 0502 allele is decreased significantly (3.1% and 11.1%, P < 0.05). The frequency of DQA1 alleles do not differ significantly between two groups. Furthermore, the frequency of DQA1 * 01/DQB1 * 0604,0605 haplotype in patients is significantly increased than that of controls (12.5% and 2.8%, P < 0.05).


CONCLUSIONS
The results suggest that DQB1 * 0604,0605 allele and DQA1 * 01/DQB1 * 0604,0605 haplotype may be a susceptible gene and haplotype of unexplained habitual abortion, while DQB1 * 0501,0502 allele may be a protective factor for habitual abortion.
Lin
Q
Q
Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China.
Lu
P
P
Wang
X
X
D000026:Abortion, Habitual / Q000235:genetics / Q000276:immunology*; D000328:Adult; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011247:Pregnancy
D006683:HLA-DQ Antigens