Expression of the c-fos gene during emotional stress in rats: the clocking effect of delta sleep-inducing peptide.
Emotional stress induced more marked increases in the expression of the c-fos gene in limbo-reticular structures of the brain in rats prognostically predisposed to emotional stress. I.p. doses of delta sleep-inducing peptide (DSIP) (60 nmol/kg) weakened the stress-induced expression of the c-fos gene. This effect was more apparent in animals predisposed to emotional stress, in which preliminary injections decreased stress-induced c-fos expression in the paraventricular hypothalamus and the medial and lateral parts of the septum. The decreased expression of the early gene c-fos in emotional stress after preliminary dosage with DSIP may reflect the leading mechanism of the anti-stress action of this peptide.
Sudakov
K V
KV
P. K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Building 4, 6 B. Nikitskaya Street. 103009 Moscow, Russia.
Umryukhin
P E
PE
Koplik
E V
EV
Anokhin
K V
KV
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000502:physiology*; D002452:Cell Count; D003220:Conflict, Psychological; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004644:Emotions / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D016762:Genes, fos / Q000235:genetics*; D007091:Image Processing, Computer-Assisted; D007103:Immobilization; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism
D003701:Delta Sleep-Inducing Peptide