[The role of CA125 in the differential diagnosis of primary ovarian carcinoma and metastatic ovarian carcinoma originated from the gastrointestinal tract].
OBJECTIVE
To assess the role of CA125 monoclonal antibody in the differential diagnosis of primary ovarian carcinoma and metastatic ovarian carcinoma originated from the gastrointestinal tract.


METHODS
Immunohistochemical study using CA125 monoclonal antibody was performed on 33 primary ovarian cancer and 50 metastatic ovarian cancer of gastrointestinal origin.


RESULTS
The positivity of CA125 was 84.5% in 33 cases of primary ovarian carcinoma, while in 50 metastatic ovarian carcinoma cases, only 4.0% was CA125 positive. The positivity of CA125 was significantly higher in primary ovarian carcinoma than metastatic ovarian carcinoma (P < 0.001).


CONCLUSIONS
CA125 monoclonal antibody is useful in the differential diagnosis of ovarian carcinoma.
Yang
W
W
Department of Pathology, Cancer Hospital, Shanghai Medical University, Shanghai 200032, China.
Zhang
T
T
Fan
J
J
D018394:CA-125 Antigen / Q000502:physiology*; D003937:Diagnosis, Differential; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000556:secondary*
D018394:CA-125 Antigen