Takayasu arteritis and atherosclerosis: illustrating the consequences of endothelial damage.
The excess of cardiovascular morbidity associated with chronic vasculitic disease has become a focus of considerable research, particularly regarding the link between endothelial damage and the development of atherosclerosis. We describe a case of Takayasu arteritis treated sub-optimally by today's standards, giving rise to an 11 year history of progressive, stepwise decline associated with cerebrovascular events and leading to early death. Postmortem findings presented a picture of chronic atherosclerotic disease but in a distribution consistent with lesions of Takayasu arteritis.
Filer
A
A
Department of Rheumatology, University of Birmingham, UK. a.filer@bham.ac.uk
Nicholls
D
D
Corston
R
R
Carey
P
P
Bacon
P
P
D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013625:Takayasu Arteritis / Q000150:complications / Q000473:pathology*; D014651:Vasa Vasorum / Q000473:pathology