title: Microcirculation after standardized application of Essaven gel on normal skin--a placebo-controlled, randomized study.
abstract: Essaven gel (EG) is a naturally derived compound indicated for the treatment of impaired venous circulation and, in microcirculatory disorders, hematomas, swelling, sprains, and all minor sport injuries. The aim of this randomized, placebo-controlled, double-blind study was to evaluate the standardized application of EG on normal skin and its effects on the microcirculation. Standardization of gel application (particularly EG) has been recently described (in healthy subjects and in clinical studies) in defined steps. The results of this study indicate that topical treatment with EG is effective in improving or positively altering the microcirculation in normal skin both at the deeper capillary levels (thermoregulatory, whole-thickness capillary bed [as shown by laser Doppler flowmetry] as well as at the nutritional capillary layer (as shown by PO2). The application of EG can be standardized to obtain consistent results with topical treatment.
authors.affiliation: Department of Biomedical Sciences, Irvine2 Vascular Laboratory, Chieti University, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Incandela
authors.forename: G
authors.initials: G
authors.lastname: Belcaro
authors.forename: A N
authors.initials: AN
authors.lastname: Nicolaides
authors.forename: G
authors.initials: G
authors.lastname: Geroulakos
authors.forename: M R
authors.initials: MR
authors.lastname: Cesarone
authors.forename: M T
authors.initials: MT
authors.lastname: De Sanctis
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004338:Drug Combinations; D004928:Escin / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D006493:Heparin / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D010743:Phospholipids / Q000008:administration & dosage* / Q000494:pharmacology; D012867:Skin / Q000098:blood supply*
chemical_list: D004338:Drug Combinations; D005343:Fibrinolytic Agents; D010743:Phospholipids; D004928:Escin; C013980:Essaven Gel; D006493:Heparin