title: Malignant myoepithelioma arising from recurrent pleomorphic adenoma of minor salivary gland.
abstract: Malignant myoepitheliomas of the salivary gland are very rare tumors which may either arise de novo or develop in a pre-existing pleomorphic adenoma. We report a case of malignant myoepithelioma of the minor salivary gland that progressed from benign pleomorphic adenoma. The original pleomorphic adenoma was resected in 1979 (the '79 tumor). The first recurrent tumor was operated in 1995 (the '95 tumor). The '95 tumor was diagnosed as pleomorphic adenoma. Although the myoepithelial tumor component was more prevalent in the '95 tumor, histological features of the first recurrent tumor were similar to the '79 tumor. The second recurrent tumor showed more aggressive clinical features (the '98 tumor). It also showed massive growth of myoepithelial tumor cells with bone invasion, which led to the diagnosis of the '98 tumor as malignant myoepithelioma. With adequate surgical margin, the patient has been free from tumor recurrence for 20 months.
authors.affiliation: Department of Otolaryngology, School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-0934, Japan. tomoy@med.kanazawa-u.ac.jp
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Yoshizaki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Himi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Minato
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ogawa
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Nikai
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Furukawa
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009208:Myoepithelioma / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000601:surgery