[The experimental study of immunization with purified surface protein antigen I/II from streptococcus mutans in BALB/c mice].
OBJECTIVE
To study the immunogenicity and immunoreactivity of purified surface protein antigen I/II from streptococcus mutans.


METHODS
Purified antigen I/II was used to immune BALB/c mice by subcutaneous injection route, and S. mutans whole cells were used as comparison.


RESULTS
ELISA showed immunization with antigen I/II highly induced both specific serum IgG antibody and specific salivary IgA antibody against antigen I/II (P < 0.01), but immunization with whole cells only induced specific serum IgG antibody (P < 0.05).


CONCLUSIONS
The study suggest purified antigen I/II is an effective candidate vaccine.
Fan
M
M
School of Stomatology, Hubei Medical University, Wuhan 430070.
Du
M
M
Bian
Z
Z
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D003731:Dental Caries / Q000517:prevention & control*; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D013295:Streptococcus mutans / Q000276:immunology*
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001428:Bacterial Vaccines