Neurotensin: an endogenous psychostimulant?
The neuropeptide neurotensin has been shown to be closely related to central dopaminergic regulation. Although emphasis has been put on its possible neuroleptic-like effects, more recent data--in particular with the use of non-peptide neurotensin receptor antagonists--suggest instead a psychostimulant-like action of endogenous neurotensin. Such contradictory potential effects open an important debate on the possible therapeutic use of compounds related to neurotensin transmission.
Bérod
Anne
A
Laboratoire de Neuropharmacologie et Neurochimie, Institute National de la Santé et de la Recherche Médicale U512, Université Claude Bernard, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France. aberod@rockefeller.univ-lyon1.fr
Rostène
William
W
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009496:Neurotensin / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use
D000697:Central Nervous System Stimulants; D009496:Neurotensin