Magnetic susceptibility of Dy-DTPA-BMA to reperfused myocardial infarction in an excised dog heart model: evidence of viable myocardium.
OBJECTIVE
To assess the effects of Dy-DTPA-BMA (sprodiamide) on ex-vivo MR imaging of reperfused acute myocardial infarction.


METHODS
Eighteen dogs were subjected to 2-hour coronary artery occlusion followed by 24-hour reperfusion. Dysprosium-chelate (Dy-DTPA-BMA) was injected into 16 dogs. Twenty minutes before their sacrifice. Two dogs did not receive the contrast medium and were used as controls. Excised hearts were imaged on T2-weighted spin-echo sequence (T2W SE) and T2*-weighted gradient recalled echo sequence (T2*W GRE), then sectioned and double-perfused for planimetric comparison.


RESULTS
Dy-DTPA-BMA induced myocardial signal loss was detected on T2W SE and on T2*W GRE images. The signal loss was observed at the subendocardial location of the myocardial wall inducing an apparent enlargement of the left ventricle cavity and a thinning appearance of the anterior myocardial wall.


CONCLUSIONS
Myocyte necrosis diminishes the potency of dysprosium to cause MR imaging signal intensity loss in reperfused myocardial infarction. Pre-infarcted myocardium with potentially reversible viability may be responsible for the effect of the contrast medium.
Zhao
S
S
Department of Radiology, Fuwai Cardiovascular Hospital, CAMS & PUMC, Beijing 100037, China.
Revel
D
D
Arteaga
C
C
Canet
E
E
Liu
S
S
Hadour
G
G
Forrat
R
R
Oksendal
A
A
D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D004285:Dogs; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000175:diagnosis*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000473:pathology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004369:Pentetic Acid