title: Hyaluronan: polysaccharide chaos to protein organisation.
abstract: Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan-protein interactions. Various studies on hyaluronan-binding proteins suggest there is considerable diversity in their mode of interaction with hyaluronan, which might result in many different bound conformations of the polysaccharide.
authors.affiliation: Department of Biochemistry, University of Oxford, UK. ajday@bioch.ox.ac.uk
authors.forename: A J
authors.initials: AJ
authors.lastname: Day
authors.forename: J K
authors.initials: JK
authors.lastname: Sheehan
mesh_terms: D002236:Carbohydrate Conformation; D018960:Hyaluronan Receptors / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D046911:Macromolecular Substances; D008958:Models, Molecular; D011133:Polysaccharide-Lyases / Q000737:chemistry; D011485:Protein Binding; D012996:Solutions; D013816:Thermodynamics
chemical_list: D018960:Hyaluronan Receptors; D046911:Macromolecular Substances; D012996:Solutions; D006820:Hyaluronic Acid; D011133:Polysaccharide-Lyases; C100002:hyaluronate lyase