[Immunoregulation of Youguiyin, Sijunzitang, Taohong Siwutang in treating patients with deficiency of kidney, spleen and blood stasis syndrome].
OBJECTIVE
To study the different immunoregulatory effects of Youguiyin, Sijunzitang, Taohong Siwutang to patients with deficiency of Kidney, Spleen and blood stasis Syndrome respectively.


METHODS
The treated group, 40 patients in each with deficiency of Kidney, Spleen and blood stasis were treated with Youguiyin, Sijunzitang and Taohong Siwutang respectively. Three control groups (20 patients each) were established respectively. Peripheral venous level of complement C3, circulating immunocomplex (CIC), interleukin-2 (IL-2), interferon-gamma (IFN-gamma), lymphocyte transformation rate (LTR), the activity of natural killer (NK) cell, and the phagocytic function of neutrophil were measured before and after treatment.


RESULTS
Sijunzitang could reduce the level of CIC (P < 0.01), raise the activity of NK cell and LRT (P < 0.01) of the patients with deficiency of Spleen syndrome; the same did the Youguiyin to that of patients with deficiency of Kidney syndrome. Also, Sijunzitang could increase the level of IL-2 in blood and the phagocytic function of neutrophil (P < 0.05); the Taohong Siwutang could lower the level of CIC to patients with blood stasis syndrome (P < 0.01), increase the activity of NK cells (P < 0.05).


CONCLUSIONS
Youguiyin, Sijunzitang could enhance the immunoregulatory function of the patients with deficiency of Spleen and Kidney, particularly the cellular immune functions, in which the Sijunzitang effect is more complete and significant, while Taohong Siwutang eliminated the effect of CIC in blood better.
Xu
D
D
Visceral Picture Research Department, Huashan Hospital, Shanghai Medical University, Shanghai (200040).
Shen
Z
Z
Wang
W
W
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D013607:Tablets; D016711:Yang Deficiency / Q000188:drug therapy / Q000276:immunology*; D016710:Yin Deficiency / Q000188:drug therapy / Q000276:immunology*
D000936:Antigen-Antibody Complex; D004365:Drugs, Chinese Herbal; D013607:Tablets; C574219:youguiyin; D007371:Interferon-gamma