Two successful pregnancies after conservative treatment of endometrial cancer and assisted reproduction.
OBJECTIVE
To report successful pregnancies after conservative management of FIGO grade I adenocarcinoma of the endometrium.


METHODS
Retrospective chart review.


METHODS
University-based assisted reproduction and oncology units.


METHODS
One patient who had two separate pregnancies.


METHODS
High-dose progestin (megestrol acetate) therapy for adenocarcinoma, followed by assisted reproduction with donor oocyte.


METHODS
Histologic evaluation of endometrium after megestrol acetate and at completion of childbearing, and successful pregnancies and deliveries.


RESULTS
The patient had complete resolution of adenocarcinoma with progestin therapy and successful delivery of two pregnancies after assisted reproduction.


CONCLUSIONS
Conservative management of International Federation of Gynecology and Obstetrics grade I adenocarcinoma of the endometrium allows preservation of childbearing.
Lowe
M Patrick
MP
Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
Bender
David
D
Sood
Anil K
AK
Davis
William
W
Syrop
Craig H
CH
Sorosky
Joel I
JI
D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D036861:Delivery, Obstetric; D016889:Endometrial Neoplasms / Q000188:drug therapy*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019290:Megestrol Acetate / Q000627:therapeutic use*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted
D019290:Megestrol Acetate