[Pathological changes between HBeAg and anti-HBe in patients with chronic hepatitis B].
OBJECTIVE
To observe the differences of pathological changes between HBeAg and anti-HBe in chronic hepatitis B.


METHODS
Liver biopsy was performed in patients with chronic hepatitis B. The histopathological grading and staging were carried out. Serum markers of viral hepatitis were tested.


RESULTS
(1) The histopathological grading and staging were closely correlated with the appearance of serum HBeAg and anti-HBe. The number of G(3-4) and S(3-4) in anti-HBe cases was significantly higher than that of G(1-2) and S(1-2), respectively. The number of G(1-2) and S(1-2) in HBeAg cases was significantly higher than that of G(3-4) and S(3-4), respectively. Significant differences were found between the group of anti-HBe cases and the group of HBeAg cases (P<0.005). (2) HBV DNA was detected in 126 of 151 HBeAg positive patients (83.4%), and the positive rate of HBV DNA in anti-HBe positive patient was 29% only.


CONCLUSIONS
(1) Severe inflammatory, necrosis and fibrosis of hepatic tissue are observed in patients with anti-HBe positive chronic hepatitis B. (2) Although HBV DNA is positively correlated to HBeAg, HBV-DNA can be detected in part of anti-HBe positive patients.
Xu
Q
Q
Department of infectious Disease, Third Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510630, China.
Shu
X
X
Chen
L
L
Zhou
Y
Y
Yao
J
J
D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D004279:DNA, Viral / Q000235:genetics; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000473:pathology*; D006801:Humans
D015415:Biomarkers; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006513:Hepatitis B e Antigens