Cardiovascular disease risk factors in HIV-infected patients in the HAART era.
HIV infection is accompanied by disturbances in lipid and glucose metabolism, which are further compounded by changes induced by antiretroviral drugs. There is increasing concern that these changes will lead to an epidemic of cardiovascular disease. Cardiovascular disease will no doubt increase, but current data indicate that the average absolute levels are likely to remain low, although patients with additional risks (smoking, hypertension, diabetes, age, family history, etc.) are certainly more susceptible. The complications of therapy need to be taken into account when deciding on the time of treatment, and reducing risk factors should become a routine aspect of the care of an HIV population that now lives longer as a result of highly active antiretroviral therapy.
Galli
M
M
Institute of Infectious Diseases and Tropical Medicine, L. Sacco Hospital, University of Milan, Italy.
Ridolfo
A L
AL
Gervasoni
C
C
D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001161:Arteriosclerosis / Q000139:chemically induced; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000453:epidemiology; D015984:Causality; D005947:Glucose / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy*; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy; D006801:Humans; D050356:Lipid Metabolism; D008060:Lipodystrophy / Q000139:chemically induced; D008659:Metabolic Diseases / Q000139:chemically induced / Q000453:epidemiology; D012307:Risk Factors
D005947:Glucose