title: The impact of metal-ions on the activity spectrum of aqueous peat extract on the smooth musculature.
abstract: METHODS
  The results of our recent studies prove the stimulating effect of aqueous peat extract (APE) on the spontaneous contractile activity (SCA) of the smooth musculature. Only substances with a molecular weight of <3,000 Dalton are able to evoke any effect. As we know from the corresponding literature, trace elements as for instance copper, manganese, lead and cadmium do also influence the SCA even when they appear in low concentrations (micromol-range). The purpose of this study therefore is to examine the influence of the trace-elements on the inspected stimulating effects which aqueous peat extract has on the SCA.
  
  
  METHODS
  During in-vitro experiments with smooth muscles in organbaths, it has been examined--under application of a standardized method--if trace-elements are the cause for the stimulating effect of aqueous peat extract on the SCA of the smooth musculature.
  
  
  RESULTS
  The results have shown that--independent from their concentration within the peat - the trace-elements do not influence the SCA of the smooth muscles.
  
  
  CONCLUSIONS
  The results can be explained by the chelating capacity of the peat-components, that leads to the absorption of the trace-elements. Additionally we can conclude that organic substances are the exclusive reason for the described effects.
authors.affiliation: Balneologisches Institut Bad Kissingen eV, Deutschland. wellbeer@cityweb.de
authors.forename: A M
authors.initials: AM
authors.lastname: Beer
authors.forename: P
authors.initials: P
authors.lastname: Zagortchev
authors.forename: J
authors.initials: J
authors.lastname: Lukano
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D007477:Ions; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D012987:Soil; D013997:Time Factors; D014131:Trace Elements / Q000032:analysis; D014867:Water / Q000378:metabolism
chemical_list: D007477:Ions; D012987:Soil; D014131:Trace Elements; D014867:Water; D010100:Oxygen