[Effect of mifepristone on the expression of tumor necrosis factor-alpha and transforming growth factor-beta in decidua of early pregnancy].
OBJECTIVE
To investigate the effect of mifepristone on the expression of tumor necrosis factor-alpha(TNF-alpha) and transforming growth factor-beta(TGF-beta) in decidua of early pregnancy.


METHODS
Thirty artificial abortion women as control and thirty drug abortion women were enrolled for study. The expressions of TNF-alpha and TGF-beta in decidua were measured with immunohistochemical method.


RESULTS
There was no significant difference of TNF-alpha positive expression rates between drug abortion group (73.33%) and artificial abortion group (70.00%, P > 0.05). TGF-beta expression rate of drug abortion group was similar to that of artificial abortion group. The highly-positive (++ and +++) TNF-alpha expression rate in drug abortion group was significantly higher than that in artificial abortion group (P < 0.05). TGF-beta expression degree in decidua of drug abortion group was significantly lower than that of artificial abortion group (P < 0.05). The ratio of TNF-alpha/TGF-beta in drug abortion group is higher than that in artificial abortion group.


CONCLUSIONS
TGF-beta has great effect on regulating the embryo development of early pregnancy. The change of TNF-alpha may be the reason of abortion. Mifepristone may interfere with embryo growth by inhibiting the activity of TGF-beta or by stimulating the secretion of TNF-alpha.
Zhang
J
J
Department of Obstetrics and Gynecology, Beijing 402 Hospital, Beijing 100039, China.
Xia
E
E
Zhang
J
J
D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology*; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy / Q000378:metabolism*; D011261:Pregnancy Trimester, First / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000021:Abortifacient Agents, Steroidal; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D015735:Mifepristone