title: The major achievements of biological products in China.
abstract: OBJECTIVE
  To review the major achievements of biological products of China in the scientific research and development.
  
  
  METHODS
  The contents of this article were selected from the original essays or reviews related to biologicals published in Chinese and foreign journals.
  
  
  METHODS
  Briefly original articles and reviews of text books published by Chinese authors in the last twenty years were selected.
  
  
  METHODS
  These data have addressed the novel vaccines and engineering genetic technologies on biologicals.
  
  
  RESULTS
  Nowadays about 200 kinds of biological products are produced in China ranging from preventive vaccines as the majority to therapeutic and diagnostic products. About 800-900 million doses of vaccines for the purpose of prophylaxis are administered annually. Biologicals have played an important role in the prevention of infectious diseases. During the former 30 years the basis for the further development of research work was set up and in the latter 20 years new achievements were made one after another, for example, the development of attenuated JE vaccine, hepatitis A live vaccine, HFRS inactivated vaccine, recombinant HB vaccine and Vi typhoid vaccine, et al.
  
  
  CONCLUSIONS
  During the past 50 years, China has made a great progress in the field of biological products, however we are still week in the aspect of basis research and backward behind the developed countries in originating new products.
authors.affiliation: National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China.
authors.forename: H
authors.initials: H
authors.lastname: Li
mesh_terms: D001688:Biological Products; D001709:Biotechnology; D002681:China
chemical_list: D001688:Biological Products