[Histomorphologic study of the bone repair materials by using the cold plasma technique].
OBJECTIVE
The purpose of this article is to improve the biological activity of the implant pretreated by use of cold plasma technic and to investigate the biological effects after implanted into bone.


METHODS
First, HA granular was set in the electric field with high voltage and vacuum, then the gaseous mixture of ammonia, hydrogen and nitrogen was led to. By coupled capacity glow discharge, the plasma was produced and the pretreatment was completed. In this way, the surface of HA granular may obtain active amino structure. Sequently, the material was implanted into bone of the animal and the dynamic changes at the material/bone interface were histologically observed.


RESULTS
The active group was definitely formed on the surface of the material after pretreatment and there were no adverse effects on the morphology and properties of the base material. Furthermore, the early formation of new bone at the interface of the material/bone was detected, and obvious effects on facilitating bone growth and osseointegration were obtained.


CONCLUSIONS
The findings indicated that cold plasma pretreatment technic was an effective method to improve the biological activity of implant material.
Chen
Z
Z
College of Stomatology, West China University of Medical Sciences, Chengdu 610041.
Zhang
M
M
Qiu
J
J
D000818:Animals; D018786:Bone Substitutes; D015921:Dental Implants; D003764:Dental Materials; D004285:Dogs
D018786:Bone Substitutes; D015921:Dental Implants; D003764:Dental Materials