title: The association of allergic sensitization in mother and child in breast-fed and formula-fed infants.
abstract: Human milk contains immunologically active substances potentially capable of altering infant immune response. As part of the prospective Children's Respiratory Study, we assessed whether the association between maternal allergic status and allergic status of the child was altered by breast-feeding. Skin-prick tests for 7 common allergens were administered to 702 6-year-old children and their mothers. The percentage of children sensitized to specific allergens, maternal skin test response to that allergen, and whether or not the child was ever breast-fed was determined. Findings indicated that specific sensitization in the mother was associated with specific sensitization in the child only if the child was breast-fed. This indirectly supports the hypothesis that contents of milk differ with maternal allergic status, and appear to affect allergic status in the child. These results suggest that milk from allergic mothers either promotes a Th2 type immune response or suppresses Th1 immune response in the child.
authors.affiliation: Department of Pediatrics, and Arizona Health Sciences Center, University of Arizona, Tucson 85724, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Wright
authors.forename: D A
authors.initials: DA
authors.lastname: Stern
authors.forename: M
authors.initials: M
authors.lastname: Halonen
mesh_terms: D000485:Allergens / Q000276:immunology; D001942:Breast Feeding; D002648:Child; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007223:Infant; D007225:Infant Food; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000276:immunology; D012882:Skin Tests; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D000485:Allergens