title: [Interleukin-1beta and depressive states].
abstract: Administration of Interleukin-1 beta (IL-1 beta) in pyrogenic and subpyrogenic doses induced a depression of social and exploratory behaviour in rats. A reduction in locomotor activity only occurred with pyrogenic doses of the IL-1 beta. The low dose induced the reduction whereas the high dose the increase of anxiety in elevated plus maze. The opposite effects of two doses of IL-1 beta were observed also in a test with saccharine.
authors.affiliation: Institute of Experimental Medicine, Russian Acad. Med. Sci., St. Petersburg, 197376, Acad. Pavlov St., 12, Russia.
authors.forename: O E
authors.initials: OE
authors.lastname: Zubareva
authors.forename: O M
authors.initials: OM
authors.lastname: Efremov
authors.forename: A S
authors.initials: AS
authors.lastname: Simbirtsev
authors.forename: V M
authors.initials: VM
authors.lastname: Klimenko
mesh_terms: D000818:Animals; D003863:Depression / Q000139:chemically induced / Q000523:psychology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior; D007375:Interleukin-1 / Q000008:administration & dosage / Q000502:physiology; D008297:Male; D018782:Maze Learning; D009043:Motor Activity; D011749:Pyrogens / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012919:Social Behavior
chemical_list: D007375:Interleukin-1; D011749:Pyrogens
vernacular_title: Interleĭkin-1beta i depressivnye sostoianiia.