title: [Evaluation of several biological markers in the prognosis of patients with node-negative breast cancer].
abstract: OBJECTIVE
  To evaluate the practical significance of microvessel count (MVC), c-erbB-2, CD44, cathepsin D and nm23 expression, and clinico-pathological parameters in the prognosis of node-negative breast cancer.
  
  
  METHODS
  Sixty two patients with node-negative invasive breast cancer were treated by surgery alone, and followed-up for at least 10 years. Microvessel count (MVC), C-erbB-2, CD44, Cathepsin D and nm23 expression were studied by immunohistochemical technique. With other clinico-pathological parameters, they were evaluated prognostically.
  
  
  RESULTS
  Univariate analysis showed that the prognostic factors influencing 10-year overall survival rate were MVC, C-erbB-2, stromal cell cath-D and CD44 expression. Multivariate analysis demonstrated that MVC was the sole independent prognostic factor determining 10-year survival.
  
  
  CONCLUSIONS
  Although MVC, c-erbB-2, stromal cell cath-D and CD44 expression are all of prognostic significance, MVC is most meaningful in evaluating prognosis of node-negative breast cancer patients.
authors.affiliation: Liaoning Provincial Tumor Hospital, Shenyang 110042, China.
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D002402:Cathepsin D / Q000032:analysis*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D002402:Cathepsin D; D018960:Hyaluronan Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases