title: Rapid pharmacotherapeutic intervention for an influenza A outbreak in the Canadian Arctic: lessons from the Sanikiluaq experience.
abstract: In January of 2000 an outbreak of influenza-like illness (ILI) was identified by Health Centre nursing staff in the remote island Inuit community of Sanikiluaq, Nunavut. A staged approach to an intervention strategy was adopted and an intervention team dispatched within 48 hours with diagnostic, prophylactic, and therapeutic capabilities and the intent to evaluate the response as well. The presence of influenza virus was determined on site in 3 out of thirteen initial cases of ILI using portable kit based rapid detection. This permitted the use of zanamivir (an inhaled neuraminidase inhibitor) for prophylaxis in 201, and for treatment in 12 persons. Amantadine was only used in 16 and 52 were ineligible for medical intervention, mostly because they fell outside of the window of opportunity or for maternal/reproductive reasons. The intervention strategy framework adopted was felt to be successful and is presented for consideration in future intervention initiatives.
authors.affiliation: Department of Medical Microbiology, University of Manitoba, Canada. pvancaesee@gov.mb.ca
authors.forename: P
authors.initials: P
authors.lastname: Van Caeseele
authors.forename: A
authors.initials: A
authors.lastname: Macaulay
authors.forename: P
authors.initials: P
authors.lastname: Orr
authors.forename: F
authors.initials: F
authors.lastname: Aoki
authors.forename: B
authors.initials: B
authors.lastname: Martin
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D001110:Arctic Regions / Q000453:epidemiology; D002170:Canada / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006146:Guanidines; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology* / Q000821:virology; D008875:Middle Aged; D011247:Pregnancy; D011714:Pyrans; D011933:Reagent Kits, Diagnostic; D012794:Sialic Acids / Q000627:therapeutic use*; D053243:Zanamivir
chemical_list: D000998:Antiviral Agents; D006146:Guanidines; D011714:Pyrans; D011933:Reagent Kits, Diagnostic; D012794:Sialic Acids; D053243:Zanamivir