Lysophosphatidic acid enhances airway response to acetylcholine in guinea pigs.
Inhalation of lysophosphatidic acid (LPA, 1-100 microg/ml) for 2 min enhanced the airway response induced by intravenous injection of ACh in guinea pigs. At 30 min after inhalation of LPA, the airway response to ACh was two fold higher than that before inhalation. This enhancement of airway response to ACh was partially inhibited by capsaicin desensitization or bilateral vagotomy. These results suggested that the enhancement of airway response to ACh induced by LPA may be due to the activation of capsaicin-sensitive fibers. It can be also contribute to bronchial asthma or other types of pulmonary disease such as cough variant asthma and atopic cough.
Hashimoto
T
T
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan. hashi@wakamoto-pharm.co.jp
Nakano
Y
Y
Ohata
H
H
Momose
K
K
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D000280:Administration, Inhalation; D000402:Airway Obstruction / Q000139:chemically induced; D000403:Airway Resistance / Q000187:drug effects; D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D016535:Bronchial Hyperreactivity / Q000139:chemically induced*; D001985:Bronchial Provocation Tests; D002211:Capsaicin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006168:Guinea Pigs; D007275:Injections, Intravenous; D008246:Lysophospholipids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D014628:Vagotomy
D000485:Allergens; D008246:Lysophospholipids; D000109:Acetylcholine; D002211:Capsaicin