title: 3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents.
abstract: This work reports the synthesis and the antiviral activities of 3-benzamido, 3-phenylureido and 3-phenylthioureido derivatives in the imidazo[1,2-a]pyridine series. The structure was proven by NMR spectroscopy. The synthesized compounds were evaluated against a large number of viruses. The 3-phenylthioureido derivative 7 showed moderate activity against human cytomegalovirus (HCMV) in vitro. The crystallographic data for 8 are also reported and explain the absence of activity against human immunodeficiency virus (HIV).
authors.affiliation: EA Groupe de Recherche en Chimie Hétérocyclique et Thérapeutique, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Tours, France.
authors.forename: A
authors.initials: A
authors.lastname: Chaouni-Enabdallah
authors.forename: C
authors.initials: C
authors.lastname: Galtier
authors.forename: H
authors.initials: H
authors.lastname: Allouchi
authors.forename: A
authors.initials: A
authors.lastname: Kherbeche
authors.forename: O
authors.initials: O
authors.lastname: Chavignon
authors.forename: J C
authors.initials: JC
authors.lastname: Teulade
authors.forename: M
authors.initials: M
authors.lastname: Witvrouw
authors.forename: C
authors.initials: C
authors.lastname: Pannecouque
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: F
authors.initials: F
authors.lastname: Fauvelle
authors.forename: C
authors.initials: C
authors.lastname: Enguehard
authors.forename: A
authors.initials: A
authors.lastname: Gueiffier
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured; D018360:Crystallography, X-Ray; D003587:Cytomegalovirus / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010671:Phenylurea Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D010948:Viral Plaque Assay
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D007093:Imidazoles; D010671:Phenylurea Compounds; D013890:Thiourea