Ileojejunal transposition delays gastric emptying and decreases fecal water content in dogs with total colectomy.
OBJECTIVE
The aim of the study was to investigate the effect of ileojejunal transposition, in which the distal ileum is interposed isoperistaltically into the proximal jejunum, on gastric emptying, gastrointestinal motility, and fecal water content in dogs with total colectomy.


METHODS
Dogs were divided into three groups: dogs with intact colons (control), total colectomy alone (sham operated group), or total colectomy and ileojejunal transposition group. The alimentary tract was reconstructed by ileal J-pouch-rectal anastomosis. Gastric emptying was measured by a validated freeze-drying method, and gastrointestinal motility was measured by strain gauge force transducers. Plasma peptide YY was measured by specific radioimmunoassay. Fecal water content was measured in dogs with total colectomy.


RESULTS
Gastric emptying of solids in the ileojejunal transposition group was delayed longer than 120 minutes after meal ingestion compared with that in the sham operated group. The duration of the digestive state was prolonged in the ileojejunal transposition group, only when compared with the control group. Plasma peptide YY was increased in the ileojejunal transposition group compared with the sham operated group. Fecal water content was decreased in the ileojejunal transposition group compared with the sham operated group.


CONCLUSIONS
Ileojejunal transposition delays gastric emptying of solids and decreases fecal water content in dogs with total colectomy, indicating that ileojejunal transposition might be able to improve intractable watery diarrhea after total colectomy.
Ueno
Tatsuya
T
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shibata
Chikashi
C
Naito
Hiroo
H
Jin
Xue-Lin
XL
Funayama
Yuji
Y
Fukushima
Kouhei
K
Matsuno
Seiki
S
Sasaki
Iwao
I
D000818:Animals; D003082:Colectomy / Q000009:adverse effects*; D003106:Colon / Q000503:physiopathology / Q000601:surgery; D003967:Diarrhea / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D004195:Disease Models, Animal; D004285:Dogs; D005243:Feces / Q000737:chemistry*; D005746:Gastric Emptying / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology; D007082:Ileum / Q000503:physiopathology / Q000601:surgery; D007581:Jejunoileal Bypass; D007583:Jejunum / Q000503:physiopathology / Q000601:surgery; D019894:Peptide YY / Q000097:blood; D013997:Time Factors
D019894:Peptide YY