Mechanism of action of thiazolidinediones.
Type 2 diabetes is associated with multiple metabolic abnormalities including insulin resistance and the procoagulant state. Thiazolidenediones are an emerging class of insulin sensitizers which have the potential to mitigate many of the complications of diabetes. Mechanisms of action of the thiazolidenediones are discussed together with their possible pitfalls. Presently, evidence to clearly define the role of thiazolidenedionesfor the treatment of type 2 diabetes is lacking.
Flemmer
M
M
Eastern Virginia Medical School, Department of Internal Medicine, Norfolk 23510, USA. flemmemc@evmsmail.evms.edu
Scott
J
J
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000097:blood / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013844:Thiazoles / Q000097:blood / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045162:Thiazolidinediones
D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione