[Effects of paracetamol and naproxen on pain syndromes of various genesis].
A comparative study of the effects of two nonsteroidal antiinflammatory drugs paracetamol and naproxen on the pain syndrome models of various etiology showed that paracetamol is more effective in the case of spinal and neuropathic pain syndromes (in which the leading pathogenic mechanisms are related to the formation of hyperactive neuron aggregates in the central nociceptive structures). Naproxen was effective in the case of adjuvant arthritis, for which the main development mechanism is related to the accumulation of inflammation mediators in tissues. It is concluded that special features of the pathogenic therapy of various pain syndromes are determined by the character of prostaglandin participation in the pathological process.
Grafova
V N
VN
Department of Pain Pathophysiology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Reshetniak
V K
VK
Kukushkin
M L
ML
Smirnova
V S
VS
Zinkevich
V A
VA
D000082:Acetaminophen / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy; D003714:Denervation; D009288:Naproxen / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve; D013118:Spinal Cord Diseases / Q000139:chemically induced / Q000188:drug therapy; D013577:Syndrome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D009288:Naproxen
Effekty paratsetamola i naproksena pri bolevykh sindromakh razlichnogo geneza.