Common origins of blood and blood vessels in adults?
After embryonic development, the vast majority of cells are differentiated and all organs are in place. Growth of the organism then ensues and continues until adulthood, whereupon cell division largely ceases. In some tissues, notably the bone marrow, skin, and gut, cell proliferation continues throughout life to replace cells lost by attrition. This regeneration is fueled by rare, long-lived, and largely quiescent stem cells that give rise to committed progenitors, which in turn generate large numbers of fully differentiated cells. Mounting evidence suggests that such cells can significantly contribute to tissue repair and regeneration in adults and may therefore prove beneficial for autologous cell and gene therapies. This review focuses on the potential of adult stem cells to give rise to hematopoietic and vascular cells. We discuss evidence that a highly purified population of adult stem cells, termed SP cells, serves as a hematopoietic progenitor and can contribute to vascular regeneration after injury. We also discuss the potential relationship of these cells to the embryonic hemangioblast.
Hirschi
K
K
Dept. of Pediatrics, Children's Nutrition Research Center, Houston, TX, USA. khirschi@bcm.tmc.edu
Goodell
M
M
D000328:Adult; D001808:Blood Vessels / Q000196:embryology*; D016228:Endothelial Growth Factors / Q000032:analysis; D004730:Endothelium, Vascular / Q000166:cytology / Q000196:embryology; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000196:embryology; D042461:Vascular Endothelial Growth Factor A
D016228:Endothelial Growth Factors; D042461:Vascular Endothelial Growth Factor A