title: Clinical efficacy of proton pump inhibitor therapy in neurologically impaired children with gastroesophageal reflux: prospective study.
abstract: OBJECTIVE
  To study the effects of proton pump inhibitors in reducing vomiting, gastrointestinal bleeding, and chest infections in institutionalised neurologically impaired children with gastroesophageal reflux.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  A regional hospital, Hong Kong.
  
  
  METHODS
  Neurologically impaired children with refractory gastroesophageal reflux.
  
  
  METHODS
  Episodes of vomiting, gastrointestinal bleeding, and pneumonia in the baseline and proton pump inhibitor treatment periods.
  
  
  RESULTS
  Nine children received proton pump inhibitor therapy for a median duration of 81 days. Mean reflux index was 9.3% (standard deviation, 5%). Dosage of omeprazole used was 1.0-2.3 mg/kg/d. Vomiting was reduced significantly with proton pump inhibitor treatment (median vomiting index [baseline]=0.4, median vomiting index [proton pump inhibitors]=0.2; P<0.05). No significant decrease in gastrointestinal bleeding or chest infection was observed.
  
  
  CONCLUSIONS
  Proton pump inhibitors significantly reduced vomiting episodes in neurologically impaired children with gastroesophageal reflux.
authors.affiliation: Department of Paediatrics, Caritas Medical Centre, 111 Wing Hong Street, Shamshuipo, Kowloon, Hong Kong.
authors.forename: K M
authors.initials: KM
authors.lastname: Cheung
authors.forename: P W
authors.initials: PW
authors.lastname: Tse
authors.forename: C H
authors.initials: CH
authors.lastname: Ko
authors.forename: Y C
authors.initials: YC
authors.lastname: Chan
authors.forename: C Y
authors.initials: CY
authors.lastname: Leung
authors.forename: K H
authors.initials: KH
authors.lastname: Chan
mesh_terms: D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D006723:Hong Kong; D006766:Hospitals, County; D006801:Humans; D008607:Intellectual Disability / Q000150:complications* / Q000175:diagnosis; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage*; D011336:Probability; D011446:Prospective Studies; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000008:administration & dosage; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors; D017494:Proton Pumps; D009853:Omeprazole