The clinical spectrum and pathogenesis of paraneoplastic disorders of the central nervous system.
Paraneoplastic neurologic disorders (PND) refer to neurologic disorders of unknown cause that occur at higher frequency in patients with cancer than in the general population. There is increasing evidence that many of these disorders are immune mediated and associated with cytotoxic antitumor immunity. The identification of the immune responses in these patients facilitates the diagnosis of the PND and has led to the cloning and characterization of the target antigens in the nervous system and tumor.
Rosenfeld
M R
MR
Department of Neurology, University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, Little Rock, Arkansas, USA. rosenfeldmyrnar@uams.edu
Dalmau
J
J
D006801:Humans; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis / Q000503:physiopathology