Serum S100B levels in patients with lupus erythematosus: preliminary observation.
S100B is an astrocytic calcium-binding protein which has been proposed as a biochemical marker of brain damage or dysfunction in acute and chronic diseases. We investigated whether serum S100B levels could be related to systemic lupus erythematosus (SLE) activity. Patients were grouped as having inactive SLE (ISLE), active SLE without central nervous system (CNS) involvement (ASLE), or active SLE with unequivocal neurologic or psychiatric manifestation (NPSLE). The control group consisted of age- and sex-matched healthy blood donors. S100B levels were determined using a luminescence immunoassay. All SLE groups had higher levels of serum S100B than the control group. Among the SLE groups, significantly higher levels of serum S100B protein were found in the NPSLE group than in the ISLE and ASLE groups, and there was no significant difference in S100B levels between the ISLE and ASLE groups. These preliminary results point to a putative relevance of serum S100B protein levels in SLE patients, specifically concerning CNS involvement present in this disease.
Portela
Luis V C
LV
Laboratório Municipal de Novo Hamburgo, Novo Hamburgo, Brazil. roska@vortex.ufrgs.br
Brenol
João C T
JC
Walz
Roger
R
Bianchin
Marino
M
Tort
Adriano B L
AB
Canabarro
Ubirajara P
UP
Beheregaray
Simone
S
Marasca
João A
JA
Xavier
Ricardo M
RM
Neto
Eurico C
EC
Gonçalves
Carlos A
CA
Souza
Diogo O
DO
D000328:Adult; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications; D020945:Lupus Vasculitis, Central Nervous System / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins
D002135:Calcium-Binding Proteins; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human