Propranolol prevents the development of venous thrombosis in rats by a platelet-dependent mechanism.
To clarify if one of the most common antihypertensive drugs, propranolol, can prevent venous thrombotic process, rats were treated with propranolol (PRO; 5 mg/kg i.p.) in an acute or chronic (14 days) manner. Both regimens resulted in a marked reduction of the systolic blood pressure (p < 0.001) and, probably as a consequence, in the shortening of the bleeding time (p < 0.01). After ligation of the vena cava, the incidence of the venous thrombosis and the thrombus weight decreased significantly in both propranolol-treated groups (p < 0.01) when compared to control rats. The antithrombotic effect of PRO was not accompanied by any changes in activated partial thromboplastin time, prothrombin time or euglobulin clot lysis time. However, long-term administfation of PRO resulted in a reduction of the ADP-induced platelet aggregation.
Gruszecki
M
M
Department of Pharmacodynamics, Medical Academy of Białystok, Poland.
Rółkowski
R
R
Pawlak
R
R
Buczko
W
W
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D001760:Bleeding Time; D001794:Blood Pressure / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000503:physiopathology
D000959:Antihypertensive Agents; D011433:Propranolol