Designing membrane electrochemical reactors for oxidoreductase-catalysed synthesis.
The purpose of this work was to design an electrochemical reactor to enhance the high selectivity of enzyme-catalysed processes. In order to develop economically efficient syntheses, the enzymes must be confined in the strict vicinity of the electrode surface. Here the confinement was achieved with a dialysis membrane in a so-called Dialysis-Membrane Electrochemical Reactor (D-MER). Oxidation of glucose into gluconic acid catalysed by glucose oxidase was a first example. The ADH-catalysed reduction of cyclohexanone into cyclohexanol was also tested in a new type of MER. NADH was electrochemically regenerated thanks to mediator (methyl viologen or rhodium complex). The key point in developing electro-enzymatic process is to ensure the perfect fitting of the reactor design to the reactions that are to be processed.
Délécouls-Servat
K
K
Laboratoire de Génie Chimique-CNRS, Université Paul Sabatier, 118 route de Narbonne, F-31062 Toulouse, France.
Basséguy
R
R
Bergel
A
A
D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D002384:Catalysis; D004563:Electrochemistry / Q000295:instrumentation*; D004867:Equipment Design; D005942:Gluconates / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005949:Glucose Oxidase / Q000378:metabolism*; D010084:Oxidation-Reduction
D005942:Gluconates; D000426:Alcohol Dehydrogenase; D005949:Glucose Oxidase; D005947:Glucose; C030691:gluconic acid