Non-human primate models of multiple sclerosis.
The phylogenetic proximity between non-human primate species and humans is reflected by a high degree of immunological similarity. Non-human primates therefore provide important experimental models for disorders in the human population that are caused by the immune system, such as autoimmune diseases. In this paper we describe non-human primate models of multiple sclerosis, a chronic inflammatory and demyelinating disease of the human central nervous system. While reviewing data from the literature and our own research we will discuss the unique role of such models in the research of basic disease mechanisms and the development of new therapies.
Brok
H P
HP
Dept. of Immunobiology, Biomedical Primate Research Centre, The Netherlands.
Bauer
J
J
Jonker
M
M
Blezer
E
E
Amor
S
S
Bontrop
R E
RE
Laman
J D
JD
't Hart
B A
BA
D000818:Animals; D001921:Brain / Q000473:pathology; D002144:Callithrix; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D008251:Macaca; D008297:Male; D009103:Multiple Sclerosis / Q000209:etiology* / Q000276:immunology; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000276:immunology
D006023:Glycoproteins; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C445081:myelin oligodendrocyte glycoprotein (35-55)