[An experimental study on the bone repairing ability of recombinant human bone morphogenetic protein-2-coral composited artificial bone].
OBJECTIVE
To improve the bone repairing ability of coral.


METHODS
Recombinant human bone morphogenetic protein-2 (rhBMP-2)-coral composited artificial bone was used. The composite was implanted into rabbit calvarial critical-size defects, and coral alone was implanted as control. The rabbits were sacrificed at 2, 6, 12 weeks respectively after operation. The bone repairing ability was assessed by histology and image analysis system.


RESULTS
The composite repairing the bone defect both in osteoconductive and osteoinductive manners was seen, repairing ability and effect were better than those of coral.


CONCLUSIONS
The composite is ideal as a bone graft substitute.
Zhang
S
S
Department of Stomatology, Nanjing General Hospital of PLA, Nanjing 210002.
Mao
T
T
Wang
H
H
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D001861:Bone Regeneration; D016025:Bone Transplantation; D003063:Cnidaria; D006801:Humans; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology; D016212:Transforming Growth Factor beta
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2