[Effectiveness of antiviral treatment of patients with chronic hepatitis C (a Polish multicenter study)].
Interferon alpha (INF) is routine treatment in patients with chronic hepatitis C. Many controlled investigations were evaluated to establish the optimal schedule of treatment with sustained virological and biochemical response. Recently, multicentre meta-analyses suggest that combination therapy (INF + Ribavirin) was more effective than treatment with interferon alone. The aim of this study was to compare the efficacy of four schedules of antiviral treatment in 445 patients with chronic hepatitis C. Combination therapy (INF + Ribavirin) given for 6 mo. and monotherapy (INF) for 18 mo. were more effective than interferon alone given for 6 mo. Treatment with INF alone for 6 mo. was demonstrated to be insufficient.
Juszczyk
J
J
Klinika Chorób Zakaźnych Instytutu Mikrobiologii i Chorób Zakaźnych AM w Poznaniu.
Bolewska
B
B
Flieger
J
J
Swietek
K
K
Adamek
B
B
Biskupska-Karasińska
M
M
Dziambor
A P
AP
Boroń-Kaczmarska
A
A
Wawrzynowicz-Syczewska
M
M
Cianciara
J
J
Kozłowska
J
J
Daniluk
J
J
Słomka
M
M
Dudziak
M
M
Zaborowski
P
P
Gładysz
A
A
Piszko
P
P
Gonciarz
Z
Z
Mazur
W
W
Machniak
M
M
Kryczka
W
W
Zarebska-Michaluk
D
D
Trocha
H
H
Witczak-Malinowska
K
K
Lakomy
E
E
Kuydowicz
J
J
Niwicka-Michałowska
A
A
D000998:Antiviral Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D011044:Poland / Q000453:epidemiology; D012254:Ribavirin / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome
D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin
Efektywność leczenia przeciwwirusowego przewlekłego zapalenia watroby typu C (wieloośrodkowe badania pòlskie).