title: A model of the muscle-fiber intracellular action potential waveform, including the slow repolarization phase.
abstract: Recent studies have shown that the slow repolarization phase or "negative afterpotential" of the intracellular muscle-fiber action potential (IAP) plays an important role in determining the shape of the extracellularly recorded motor-unit action potential (MUAP). This paper presents a model of the IAP waveform as the sum of a spike and an afterpotential, both represented by simple analytical expressions. The model parameters that specify the sizes of the spike and afterpotential are shown to be proportional to the quadrupole and dipole moments of the transmembrane current distribution associated with the spike of the wave of excitation. The model provides a computationally efficient method for simulating the MUAP, and it can be reliably inverted to estimate the model parameters from empirical IAP and MUAP waveforms.
authors.affiliation: Rehabilitation Research and Development Center, VA Palo Alto Health Care System, 3801 Miranda Ave., Palo Alto, CA 94304 USA. mcgill@roses.stanford.edu
authors.forename: K C
authors.initials: KC
authors.lastname: McGill
authors.forename: Z C
authors.initials: ZC
authors.lastname: Lateva
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D004576:Electromyography; D008959:Models, Neurological