title: [Transarterial chemoembolization with high dose iodized oil for the treatment of large hepatocellular carcinoma].
abstract: OBJECTIVE
  To report the method and result of high dose iodized oil chemoembolization for the treatment of large hepatocellular carcinoma.
  
  
  METHODS
  From 1993 to 1998, 163 patients with unresectable hepatocellular carcinoma were treated by transarterial chemoembolization (TACE) with more than 20 ml lipiodol.
  
  
  RESULTS
  TACE with high dose lipiodol was well tolerated by the treated patients. In patients whose liver function was of Child A stage, or in patients whose residual indocyanine green level 15 min after injection was less than 20%, the frequency of post-treatment hepatic insufficiency was not significantly different from that of patients treated with routine dose of lipiodol. On CT scan at 4 wk after TACE, more lipiodol was located in the liver. The 1-, 2-,3-year survival rate of patients in Child A stage was 79.8%, 50.3%, and 38.5%, respectively, as compared to 57.5%, 24.8% and 8.37%, respectively in patients treated with routine dose of lipiodol (P = 0.0136).
  
  
  CONCLUSIONS
  High dose lipiodol TACE for the treatment of large hepatocellular carcinoma is practically acceptable with better therapeutic effect but its use should be limited to those patients with compensated liver function.
authors.affiliation: Cancer Center, Sun Yet-sen University of Medical Sciences, Guangzhou 510060, China.
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000209:etiology; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage* / Q000009:adverse effects; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome; D014839:Vomiting / Q000209:etiology
chemical_list: D007459:Iodized Oil