title: [Our experience in the treatment of polycystic ovary syndrome with Metformin].
abstract: Basing on the key role of the hyperinsulinemia in the etiopathogenesis of the Polycystic ovary syndrome, the authors treat the affected women with Metformin. In an 1 year prospective study, including 30 women, they assess the effect of the application of Metformin in relation to some indexes--BMI, WHR, IRI, LH, LH/FSH ratio. After analysing the results, it is reported for a decrease in the absolute values of BMI, WHR and a tendency for redistribution of the adipose tissue from visceral to gynoid type. They report for a statistical reliability in the decrease of LH and LH/FSH ratio. The level of IRI decreases pointedly at every stage of the study. 28 of the patients influence favourably in one or other degree, regarding the menstrual cycles. A good results is also reported in reference to Arterial Hypertension. According to the authors, Mtformin is a good alternative in the treatment of the PCOS.
authors.forename: M
authors.initials: M
authors.lastname: Mitkov
authors.forename: B
authors.initials: B
authors.lastname: Pekhlivanov
authors.forename: S
authors.initials: S
authors.lastname: Simeonov
authors.forename: G
authors.initials: G
authors.lastname: Velchev
mesh_terms: D015992:Body Mass Index; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000517:prevention & control; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation / Q000187:drug effects; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008687:Metformin
vernacular_title: Nashiiat opit pri lechenieto na polikistoznata bolest na iachinitsite s Metformin.