title: [Structural characteristics of osteopontin mRNA].
abstract: Conservatism of primary and secondary structure of osteopontin mRNA in vertebrates of various taxes was studied using computer analysis and blot-hybridization procedure. Relatively high rate of evolution of a nucleotide sequence of osteopontin gene was revealed. Formation of hairpin-loop structures by adjacent sequences and a high content of AU-pairs indicate more flexible structure of the mammalian osteopontin mRNA as compared with the avian one. It has been detected some AU-enriched regions in 3'-terminal untranslated sequences, which presence is characteristic for short-lived mRNA. Evolutionary conserved subsequences in 3'- and 5'-terminal regions were suggested to be determinants of RNA-protein interaction in cytoplasm.
authors.forename: O P
authors.initials: OP
authors.lastname: Berezovskaia
authors.forename: A P
authors.initials: AP
authors.lastname: Sidorenko
authors.forename: D V
authors.initials: DV
authors.lastname: Mukha
mesh_terms: D020413:3' Untranslated Regions / Q000737:chemistry; D020121:5' Untranslated Regions / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001717:Birds; D017124:Conserved Sequence; D019143:Evolution, Molecular; D015151:Immunoblotting; D008322:Mammals; D008432:Mathematical Computing; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D053495:Osteopontin; D017433:Protein Structure, Secondary; D012333:RNA, Messenger / Q000737:chemistry* / Q000235:genetics; D012795:Sialoglycoproteins / Q000737:chemistry / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D012333:RNA, Messenger; D012795:Sialoglycoproteins; D053495:Osteopontin
vernacular_title: Strukturnye osobennosti mRNK osteopontina.