Evidence for postjunctional serotonin (5-HT1) receptors in the trigeminocervical complex.
Units linked to stimulation of the superior sagittal sinus were identified and recorded from in the trigeminocervical complex of the anesthetized cat. Iontophoresis of glutamate NMDA receptor agonists increased the baseline-firing rate of these neurons. Coejection of sumatriptan, 4991W93, or ergometrine resulted in a significant reduction in NMDA agonist-induced increases in firing. These data establish the existence of triptan-sensitive (5-HT1) receptors on postsynaptic central trigeminal neurones.
Goadsby
P J
PJ
Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK. peterg@ion.ucl.ac.uk
Akerman
S
S
Storer
R J
RJ
D000818:Animals; D001921:Brain / Q000098:blood supply; D002415:Cats; D002572:Cervical Plexus; D004558:Electric Stimulation; D004874:Ergonovine / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D020773:Headache Disorders / Q000188:drug therapy / Q000378:metabolism; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D007478:Iontophoresis; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism*; D010080:Oxazoles / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists; D011985:Receptors, Serotonin / Q000378:metabolism*; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D018170:Sumatriptan / Q000494:pharmacology; D014278:Trigeminal Nuclei / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
C423339:4991W93; D018690:Excitatory Amino Acid Agonists; D007211:Indoles; D010080:Oxazoles; D016194:Receptors, N-Methyl-D-Aspartate; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists; D006710:Homocysteine; C007956:homocysteic acid; D018698:Glutamic Acid; D018170:Sumatriptan; D004874:Ergonovine