Use of isotopes and LC-MS-ESI-TOF for mechanistic studies of tienilic acid metabolic activation.
Belghazi
M
M
Université René Descartes, CNRS UMR 8601 Paris, France.
Jean
P
P
Poli
S
S
Schmitter
J M
JM
Mansuy
D
D
Dansette
P M
PM
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D002851:Chromatography, High Pressure Liquid; D002994:Clofibrate / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D007553:Isotope Labeling; D008862:Microsomes, Liver / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D012997:Solvents; D039181:Steroid 16-alpha-Hydroxylase; D013250:Steroid Hydroxylases / Q000378:metabolism*; D013989:Ticrynafen / Q000378:metabolism*; D014528:Uricosuric Agents / Q000378:metabolism*; D014867:Water / Q000378:metabolism; D015003:Yeasts
D012997:Solvents; D014528:Uricosuric Agents; D014867:Water; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C082185:CYP2C18 protein, human; D039181:Steroid 16-alpha-Hydroxylase; D013989:Ticrynafen; D002994:Clofibrate; D010100:Oxygen