[Histocompatibility HLA system in man. Considerations in the light of current concept. Part III. The relationship between HLA antigens and disease susceptibility].
A large number of diverse diseases are associated with genetic markers of the MHC complex. The analysis of such disease associations is complicated by the diversity of genetic information located within the HLA complex. Recent advances in the structural analysis of HLA genes and gene products contribute a new perspective to questions of HLA-associated disease. HLA-associated disease are caused by an interplay of many different genes and environmental factors, where HLA complex genes most often confer the strongest genetic predisposition. With this knowledge at hand, identification of individuals at high risk to develop autoimmune and other potentially disabling diseases should be used in order to effectively prevent or halt disease development. This may be a major part of the clinical HLA field in the near future. In this article, we present and interpret some such recent information, especially a possible molecular mechanism of the HLA associations.
Kedzierska
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Samodzielna Pracownia Immunologii Kliniczenj Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Turowski
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G
D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans
D005819:Genetic Markers; D006680:HLA Antigens
Układ zgodności tkankowej człowieka--HLA. Rozwazania w świetle aktualnych pogladów. III. Współzalezność miedzy antygenami HLA a wystepowaniem określonych chorób.