Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats.
Numerous etiological studies have established a positive clinical association between hypertension and erectile dysfunction. However, to date, the mechanism underlying this dysfunction remains to be established. In this study, we demonstrate the presence of erectile dysfunction in two rat models of hypertension, and hypothesize that increased vasoconstrictor signaling via Rho-kinase contributes to the decreased erectile response. We found deoxycorticosterone-salt and stroke prone-spontaneously hypertensive rats to exhibit a decreased erectile response, recorded as intracavernosal pressure/mean arterial pressure (ICP/MAP) upon electrical stimulation of the major pelvic ganglion. As previously shown, inhibition of Rho-kinase activity by intracavernosal injection of the selective inhibitor, Y-27632, resulted in an increase in ICP/MAP. However, Y-27632 was significantly less effective at increasing ICP/MAP in the hypertensive as compared to normotensive rats. Additionally, intracavernosal injection of Y-27632 potentiated the voltage-stimulated increase in ICP/MAP in both hypertensive and normotensive rats, but was less effective at potentiating the voltage-mediated erectile response in the hypertensive rats. Altogether, our data demonstrate a decreased erectile response in a mineralocorticoid and genetic model of hypertension, and suggest the role of increased cell signaling by Rho-kinase in the vasoconstrictor activity of erectile dysfunction associated with hypertension.
Chitaley
K
K
Department of Physiology, University of Michigan, Ann Arbor, Michigan, USA. kanchanc@umich.edu
Webb
R C
RC
Dorrance
A M
AM
Mills
T M
TM
D000577:Amides / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D004558:Electric Stimulation; D005724:Ganglia / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D010388:Pelvis / Q000294:innervation; D010410:Penile Erection; D010413:Penis / Q000098:blood supply; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride; D020521:Stroke / Q000235:genetics
D000577:Amides; D000959:Antihypertensive Agents; D011725:Pyridines; C108830:Y 27632; D003900:Desoxycorticosterone; D012965:Sodium Chloride