Finasteride. Does it affect spermatogenesis and pregnancy?
OBJECTIVE
A few women have asked me whether finasteride, taken by their partners for male pattern baldness, will affect their pregnancies. The product monograph is very alarming: it sounds as if even handling the medication could cause harm, especially to a male fetus. Should a man stop taking finasteride if his partner is planning pregnancy or is pregnant? What is the risk to the fetus if its mother accidentally handles crushed or broken tablets?


CONCLUSIONS
To date, there are no reports of adverse pregnancy outcomes among women exposed to finasteride. Taking 1 mg of finasteride daily did not have any clinically significant effect on men's semen. Absorption through the skin while handling tablets is extremely unlikely to cause fetal exposure or harm. There is no reason to discontinue the drug. Motherisk is currently following up women who are pregnant or planning pregnancy and whose partners are taking finasteride.
Pole
M
M
Hospital for Sick Children, Toronto, Ont.
Koren
G
G
D000279:Administration, Cutaneous; D000328:Adult; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D018120:Finasteride / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000517:prevention & control*; D012307:Risk Factors; D013091:Spermatogenesis / Q000187:drug effects*; D013607:Tablets
D004791:Enzyme Inhibitors; D013607:Tablets; D018120:Finasteride