Bax and BH3-domain-only proteins in p53-mediated apoptosis.
Activation of mitochondria-mediated apoptosis represents a major anti-tumor response of p53. One of the mechanisms for p53 to induce mitochondria-mediated cell death events is to activate genes that are directly involved in the initiation of mitochondria-induced apoptosis. Among them are Bcl-2 family members, Noxa, PUMA, and Bax. They have been shown to be direct targets in p53-mediated apoptosis. The Bax protein belongs to the multidomain Bcl-2 family, while Noxa and PUMA are BH3-domain-only proteins. This review focuses on discussing the function of these protein in p53-mediated apoptosis and how they contribute to the decision making of p53 response: growth arrest or apoptosis.
Wu
Xiangwei
X
Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. xiangwei@bcm.tmc.edu
Deng
Yibin
Y
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology*; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*; D051028:bcl-2-Associated X Protein; D018909:src Homology Domains
D048868:Adaptor Proteins, Signal Transducing; C494826:BAX protein, human; C486655:BMF protein, human; D002352:Carrier Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D051028:bcl-2-Associated X Protein