Apoptotic proteins. p53 and c-myc related pathways.
c-Myc and p53 are two proteins that have critical roles in the regulation of apoptosis and the cell cycle. The authors review how these two proteins are thought to control the opposing events of proliferation and apoptosis and examine whether their well-documented biological roles in tumorigenesis can be applied to the vascular system.
McCarthy
N
N
Division of Cardiovascular Medicine, Addenbrookes Hospital, Cambridge, United Kingdom.
Mercer
J
J
Bennett
M
M
D017209:Apoptosis / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D016271:Proto-Oncogene Proteins c-myc; D016159:Tumor Suppressor Protein p53