Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo.
The mouse develops five pairs of mammary glands that arise during mid-gestation from five pairs of placodes of ectodermal origin. We have investigated the molecular mechanisms of mammary placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b, both of which fail to develop normal mammary glands. Mammary placode induction involves two different signaling pathways, a FGF10/FGFR2b-dependent pathway for placodes 1, 2, 3 and 5 and a FGF10/FGFR2b-independent pathway for placode 4. Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor.
Mailleux
Arnaud André
AA
UMR144-CNRS/Institut Curie, 26 rue d'Ulm 75248 Paris cedex 05, France.
Spencer-Dene
Bradley
B
Dillon
Christian
C
Ndiaye
Delphine
D
Savona-Baron
Catherine
C
Itoh
Nobuyuki
N
Kato
Shigeaki
S
Dickson
Clive
C
Thiery
Jean Paul
JP
Bellusci
Saverio
S
D000818:Animals; D005260:Female; D051526:Fibroblast Growth Factor 10; D005346:Fibroblast Growth Factors / Q000502:physiology*; D017353:Gene Deletion; D008321:Mammary Glands, Animal / Q000196:embryology* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009024:Morphogenesis / Q000502:physiology; D011247:Pregnancy; D051497:Receptor, Fibroblast Growth Factor, Type 2; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology*; D015398:Signal Transduction
C496464:Fgf10 protein, mouse; D051526:Fibroblast Growth Factor 10; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; D051497:Receptor, Fibroblast Growth Factor, Type 2