title: Lymphocyte subsets in lung tissues of interstitial pneumonia associated with untreated polymyositis/dermatomyositis.
abstract: This study was designed to evaluate the distribution of lymphocyte subsets in lung specimens obtained by surgical lung biopsy from 12 patients with interstitial pneumonia associated with untreated polymyositis/dermatomyositis (PM/DM). Differences of histological findings and distributions of lymphocyte subsets between PM and DM were also evaluated. Distributions of B lymphocytes, CD4-positive T lymphocytes, and CD8-positive T lymphocytes were evaluated immunohistochemically. Interstitial pneumonia was pathologically classified as basically nonspecific interstitial pneumonia (NSIP) in all patients. Immunohistochemically, the distribution of B lymphocytes was mostly restricted to inside and/or around lymphoid follicles. The CD4-positive T lymphocytes were distributed diffusely in fibrotic areas and unrelated to lymphoid follicles. Most CD8-positive T lymphocytes were diffusely distributed, especially in relatively normal alveoli. There were no significant differences in the distribution of lymphocyte subsets between PM and DM. Although the distribution of B lymphocytes and CD4- and CD8-positive T lymphocytes in the lung were different, there were no significant differences in distributions of lymphocyte subsets between PM and DM.
authors.affiliation: Department of Clinical Pathology, National Okayama Medical Center, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Yamadori
authors.forename: J
authors.initials: J
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Kajitani
authors.forename: S
authors.initials: S
authors.lastname: Bandoh
authors.forename: M
authors.initials: M
authors.lastname: Tokuda
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: T
authors.initials: T
authors.lastname: Yoshinouchi
authors.forename: M
authors.initials: M
authors.lastname: Okahara
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaji
authors.forename: Y
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Ishida
mesh_terms: D000368:Aged; D001992:Bronchoalveolar Lavage Fluid; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D003882:Dermatomyositis / Q000097:blood / Q000473:pathology; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000473:pathology*; D016131:Lymphocyte Subsets / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000097:blood / Q000473:pathology