tPA via infusion catheters followed by continuous IV infusion for 3 days prevents intimal hyperplasia after balloon injury.
A rabbit model was used to examine the effects of tissue plasminogen activator (tPA) on development of intimal hyperplasia following balloon injury. Thirty-two hereditary hypercholesterolemic (KHC) rabbits underwent percutaneous transluminal coronary artery balloon catheterization and injury to the common iliac artery, after which they were divided into four groups: untreated (control); Dispatch catheterized-30 minutes local saline delivery [D(+)-tPA(-)]; D(+)-30 minutes local tPA delivery (0.6 mg/kg) [D(+)-tPA(30 min)]; and D(+)-30 minutes local tPA + 3 days intravenous infusion (0.6 mg/kg/24 h) [(D(+)-tPA(30 min + 3 d)]. Twenty-eight days later, the intimal cross-sectional areas of all three Dispatch catheterized groups were significantly smaller than those of control groups, as were the intimal/medial area ratios. Moreover, the intima/media ratios of the D(+)-tPA(30 min + 3 d) group were significantly smaller than those of the D(+)-tPA(-) group. Thus, local delivery of tPA via Dispatch catheters followed by continuous intravenous infusion of tPA for 3 days prevented intimal hyperplasia after angioplasty.
Kanamasa
K
K
The First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan. kanamasa@med.kindai.ac.jp
Inoue
Y
Y
Otani
N
N
Naito
N
N
Morii
H
H
Ikeda
A
A
Taniguchi
M
M
Ishida
N
N
Hayashi
T
T
Ishikawa
K
K
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D000818:Animals; D002404:Catheterization; D006965:Hyperplasia; D007262:Infusions, Intravenous; D011817:Rabbits; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D017539:Tunica Intima / Q000293:injuries* / Q000473:pathology*
D010959:Tissue Plasminogen Activator