[Effects of metformin on hyperinsulinemic anovulation].
OBJECTIVE
To investigate the effects of metformin on serum testosterone (T) levels and ovulation in hyperinsulinemic women.


METHODS
Twenty-nine patients with hyperinsulinemic anovulation were treated with metformin for 12 weeks. Among them 19 had history of clomiphene(CC) treatment with 11 cases failure. CC was given again after one month of metformin treatment. Serum T, luteinizing hormone, follicle-stimulating hormone, insulin(Ins) levels were measured after 4 weeks of treatment. Basic body temperature was also observed.


RESULTS
Serum T and Ins levels declined significantly after 4 weeks of metformin treatment [(2.7 +/- 1.6) nmol/L Vs (1.9 +/- 1.0) nmol/L, (49.2 +/- 34.1) mU/L Vs (25.3 +/- 23.9) mU/L, P < 0.05, P < 0.05 respectively]. Eight cases ovulated spontaneously and 8 cases with history of CC failure became ovulatory during CC treatment.


CONCLUSIONS
Metformin is effective for suppressing serum T levels and improving the outcome of ovulation.
Li
R
R
Department of Gynecology, Shanghai First Maternal and Infant Health Hospital, Shanghai 200040, China.
Lin
J
J
Zhou
J
J
D000328:Adult; D000858:Anovulation / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000503:physiopathology*; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008687:Metformin / Q000494:pharmacology* / Q000627:therapeutic use; D010060:Ovulation / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D007004:Hypoglycemic Agents; D013739:Testosterone; D008687:Metformin