[Clinical and experimental study of yushen jiangtang tablet in treating non-insulin dependent diabetes mellitus].
OBJECTIVE
To evaluate the therapeutic effect and safety of Yushen Jiangtang Tablet (YSJTT) in treating non-insulin dependent diabetes mellitus (NIDDM) of Qi-Yin Deficiency Syndrome (QYD).


METHODS
One hundred and one patients of NIDDM with QYD were treated with YSJTT and compared with 60 patients of the control group treated with Shenqi Jiangtang Tablet. The experimental study on pharmacologic effect and toxicity of YSJTT was also conducted.


RESULTS
The total effective rate of the YSJTT group was 87.12% and the markedly effective rate 44.55%, while those of the control group were 70.00% and 18.33% respectively, comparison between the two groups showed that the effect of the YSJTT group was superior to that of the control group, P < 0.01. No acute or chronic toxic or side effect was found in animal experiment. Pharmacologic study showed that YSJTT had obvious effect in decreasing blood glucose and serum triglyceride levels in rats with alloxan induced diabetes.


CONCLUSIONS
YSJTT is effective in treating NIDDM, and apparent toxic-side effect of it was not found.
Xia
D
D
Institute of TCM, Sichuan Academy of TCM, Chengdu (610031).
Zeng
Y
Y
Liao
Z
Z
D000328:Adult; D000368:Aged; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008875:Middle Aged; D011897:Random Allocation; D051381:Rats; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D014280:Triglycerides