title: A highly enantioselective intramolecular Heck reaction with a monodentate ligand.
abstract: An efficient enantioselective intramolecular Heck reaction of cyclohexadienones, using readily available and modular TADDOL-based mono- and bidentate phosphoramidites as chiral ligands and not requiring any additives, has been developed. Excellent enantioselectivities up to 96% ee are reached for the first time in a Heck reaction with monodentate ligands.
authors.affiliation: Stratingh Institute, Department of Organic Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Rosalinde
authors.initials: R
authors.lastname: Imbos
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
mesh_terms: D001685:Biological Factors / Q000138:chemical synthesis; D003510:Cyclohexanes / Q000737:chemistry*; D053138:Cyclohexenes; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001685:Biological Factors; D003510:Cyclohexanes; D053138:Cyclohexenes; D009943:Organophosphorus Compounds; C434331:phosphoramidite; C048401:1,4-cyclohexadiene