An efficient synthesis of morpholin-2-one derivatives using glycolaldehyde dimer by the Ugi multicomponent reaction.
A new one-pot procedure for the efficient synthesis of novel 3-substituted morpholin-2-one-5-carboxamide derivatives using commercially available glycolaldehyde dimer as a bifunctional component with various alpha-amino acids and isocyanides by the Ugi five-center three-component reaction (U-5C-3CR) was developed. [reaction: see text]
Kim
Y B
YB
Biochemicals Research Center, Korea Institute of Science and Technology, Seoul, 130-650, Korea.
Choi
E H
EH
Keum
G
G
Kang
S B
SB
Lee
D H
DH
Koh
H Y
HY
Kim
Y
Y