High-throughput structural proteomics using x-rays.
Following the recent sequencing of the human genome, the focus has shifted from the DNA level to the protein level, with the goal of elucidating function. Technical developments in x-ray crystallography mean that the crystal structures of these new proteins can now been determined at an unprecedented rate, which assists in functional analysis and rational drug-design programmes.
Jhoti
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Astex Technology, Cambridge, UK. h.jhoti@astex-technology.com
D018360:Crystallography, X-Ray / Q000379:methods*; D015195:Drug Design; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D012984:Software
D011506:Proteins