title: Protein tyrosine phosphatases.
abstract: The molecular mechanisms of signal transduction have been at the focus of increasingly intense scientific research. As a result, our understanding of protein tyrosine kinase-mediated signaling has advanced at an unprecedented pace during the past decade. In contrast, the study of protein tyrosine phosphatases has lagged behind, but is now gathering momentum and is predicted to become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the art in our understanding of the structure, regulation and role of protein tyrosine phosphatases with emphasis on the lymphocyte system.
authors.affiliation: The Burnham Institute, La Jolla Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. tmustelin@burnham-inst.org
authors.forename: T
authors.initials: T
authors.lastname: Mustelin
authors.forename: G S
authors.initials: GS
authors.lastname: Feng
authors.forename: N
authors.initials: N
authors.lastname: Bottini
authors.forename: A
authors.initials: A
authors.lastname: Alonso
authors.forename: N
authors.initials: N
authors.lastname: Kholod
authors.forename: D
authors.initials: D
authors.lastname: Birle
authors.forename: J
authors.initials: J
authors.lastname: Merlo
authors.forename: H
authors.initials: H
authors.lastname: Huynh
mesh_terms: D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000201:enzymology
chemical_list: D017027:Protein Tyrosine Phosphatases