Novel amidine conjugates of the ornithine moiety of the macrocyclic antifungal lipopeptidolactone FR901469.
Barrett
D
D
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan. david_barrett@po.fujisawa.co.jp
Tanaka
A
A
Watabe
E
E
Maki
K
K
Ikeda
F
F
D000578:Amidines / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D006461:Hemolysis / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D009952:Ornithine / Q000737:chemistry / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D055666:Lipopeptides
D000578:Amidines; D000935:Antifungal Agents; D047630:Depsipeptides; D009952:Ornithine; D010456:Peptides, Cyclic; C417112:FR 901469; D055666:Lipopeptides