title: [Correction of sleep disorders and efficacy of antihypertensive monotherapy in elderly patients: use of ivadal].
abstract: OBJECTIVE
  To assess effects of ivadal (zolpidem) on arterial pressure (AP) in the cycle sleep-awake in aged patients with insomnia who have failed hypotensive monotherapy with different drugs, i.e. whose AP remained abnormal at night.
  
  
  METHODS
  The trial included 25 aged patients (17 females, 8 males, mean age 66.4 +/- 3.7 years) with isolated systolic arterial hypertension (AH) of the first-second degree (WHO classification, 1999) and insomnia. AH duration averaged 8.7 +/- 3.7 years. All the patients have received antihypertensive monotherapy. As shown by the initial 24-h monitoring, patients with elevated night AP had significantly lower mean score by the questionnaire "Subjective Sleep Characteristics" and more frequently suffer from insomnia. These patients were given a hypnotic drug ivadal (zolpidem) in a single daily dose 5 mg in the evening for 10 days. On the treatment night 10 monitoring of AP was repeated.
  
  
  RESULTS
  Ivadal treatment has significantly improved all the subjective parameters of sleep and 24-h AP profile, lowered sleep and awake AP.
  
  
  CONCLUSIONS
  Ivadal treatment raises efficacy of a hypotensive monotherapy in aged patients with isolated systolic AH and insomnia.
authors.forename: A I
authors.initials: AI
authors.lastname: Martynov
authors.forename: O D
authors.initials: OD
authors.lastname: Ostroumova
authors.forename: V I
authors.initials: VI
authors.lastname: Mamaev
authors.forename: A A
authors.initials: AA
authors.lastname: Novinskiĭ
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000627:therapeutic use*; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications / Q000188:drug therapy*; D014851:Wakefulness / Q000187:drug effects; D000077334:Zolpidem
chemical_list: D006993:Hypnotics and Sedatives; D011725:Pyridines; D000077334:Zolpidem
vernacular_title: Vzaimosviaz' korrektsii narusheniĭ sna i éffektivnosti antigipertenzivnoĭ monoterapii u pozhilykh bol'nykh: vozmozhnosti primeneniia ivadala.