[Experimental study on effect of yishen shengxue tablet in treating aplastic anemia].
OBJECTIVE
To study the mechanism of Yishen Shengxue Tablet (YSSXT) in treating aplastic anemia.


METHODS
Observing the effect of YSSXT on hematopoietic, immunologic, anti-infection and body resistance of model mice of aplastic anemia.


RESULTS
YSSXT had marked effect of promotion on recovering myleran injury induced reduction of colony forming unit-spleen (CFU-S), colony forming unit-culture (CFU-C), colony forming unit-erythrocyte (CFU-E), markedly promoting the peritoneal macrophage phagocytosis of normal mice, also markedly lower the mortality of Staphylococcus aureus inoculated mice, and elevate the anoxia resistant ability under normal pressure of anoxic mice, prolonging their survival time.


CONCLUSIONS
Using YSSXT to treat aplastic anemia that the effectiveness might be realized through promoting the proliferation of hematopoietic stem cells of bone marrow, enhancing the non-specific immunity, and the anti-infection as well as body resistance.
Zhou
A
A
Department of Hematology, Xiyuan Hospital, China Academy of TCM, Beijing (100091).
Wang
T
T
Yang
J
J
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000741:Anemia, Aplastic / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D002066:Busulfan; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D013607:Tablets
D000276:Adjuvants, Immunologic; D000890:Anti-Infective Agents; D004365:Drugs, Chinese Herbal; D013607:Tablets; D002066:Busulfan