The proline form of p53 codon 72 polymorphism is associated with endometriosis.
OBJECTIVE
To evaluate the association between endometriosis and the p53 polymorphism.


METHODS
Prospective study.


METHODS
Department of gynecology and genetics in a medical center.


METHODS
Women with and without endometriosis.


METHODS
Women were categorized as having moderate or severe endometriosis (n = 118) or no endometriosis (n = 140).


METHODS
Polymerase chain reaction was used to detect p53 codon 72 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity). Associations between endometriosis and p53 polymorphisms were evaluated.


RESULTS
The distributions of different p53 polymorphisms differed significantly between groups. The respective proportions of arginine homozygotes, heterozygotes, and proline homozygotes were 10.2%, 66.9%, and 22.9% in the group with endometriosis and 30.7%, 50%, and 19.3% in the group without endometriosis.


CONCLUSIONS
Endometriosis is associated with p53 polymorphism. p53 arginine homozygotes have lower risk for endometriosis. Heterozygotes and proline homozygotes have higher risk for endometriosis.
Chang
Chi Chen
CC
Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan.
Hsieh
Yao Yuan
YY
Tsai
Fuu Jen
FJ
Tsai
Chang Hai
CH
Tsai
Horng Der
HD
Lin
Cheng Chieh
CC
D019943:Amino Acid Substitution; D044466:Asian People; D003062:Codon / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics* / Q000601:surgery; D005260:Female; D016158:Genes, p53; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011392:Proline; D012016:Reference Values; D013624:Taiwan; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D003062:Codon; D016159:Tumor Suppressor Protein p53; D011392:Proline