title: [Effect of total flavonoids of Astragalus on nitroxide in ischemia reperfusion injury].
abstract: OBJECTIVE
  To study the protective effect of total flavonoids of Astragalus (TFA) on ischemia/reperfusion injury.
  
  
  METHODS
  Change of nitrite (NO2-), the terminal product of nitric oxide (NO) metabolism, and the effect of TFA and chloroquine (a phospholipase A2 inhibitor) on it were observed with hemorrhagic shock/reperfusion injury (S/R) rabbit model.
  
  
  RESULTS
  Plasma NO2- content was positively correlated with blood pH and total carbon dioxide content lowering. TFA and chloroquine could block the decrease of NO in certain degree and might have some effect on maintaining acid-base balance of body.
  
  
  CONCLUSIONS
  TFA has protective effect on ischemia/reperfusion injury.
authors.affiliation: General Hospital of PLA, Beijing, China.
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D011817:Rabbits; D011897:Random Allocation; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000150:complications / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D009569:Nitric Oxide