Role of activation of the sympathoadrenal system in the realization of immune reactions during acute poisoning with organophosphorus compounds.
Experiments on Wistar rats showed that acute poisoning with organophosphorus compound dimethyldichlorovinylphosphate (0.2 and 0.8 LD50) was accompanied by suppression of the major immune reactions. Increasing the concentration of epinephrine and norepinephrine in the plasma produced less pronounced opposite effects, except for the influence on natural killer activity.
Zabrodskii
P F
PF
Saratov State Medical University.
Germanchuk
V G
VG
D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D004006:Dichlorvos / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000506:poisoning; D007107:Immune System / Q000187:drug effects*; D007306:Insecticides / Q000506:poisoning*; D007928:Lethal Dose 50; D008297:Male; D009638:Norepinephrine / Q000506:poisoning; D062025:Organophosphate Poisoning; D051381:Rats; D017208:Rats, Wistar
D007306:Insecticides; D004006:Dichlorvos; D009638:Norepinephrine; D004837:Epinephrine