title: Primary malignant melanoma arising in a cystic necrotic ovarian teratoma.
abstract: Cystic ovarian teratomas are common tumours. Malignant melanoma developing in a teratoma, however, is an extremely rare diagnosis. To date, only 24 cases have been reported in the literature. A 56-year-old patient underwent laparotomy for an ovarian tumour. Histopathologic examination revealed a primary malignant melanoma within a cystic necrotic teratoma, possibly arising from uveal cells. An extraovarian primary melanoma could not been found. After 7 months of operation metastasis to the vertebral column occurred, 2 months later liver metastases were diagnosed. The patient died of the disease 14 months after initial diagnosis.
authors.affiliation: Department of Dermatology, University of Tuebingen, Liebermeisterstr 25, 72076, Tübingen, Germany. matthias.moehrle@med.uni-tuebingen.de
authors.forename: M
authors.initials: M
authors.lastname: Moehrle
authors.forename: H
authors.initials: H
authors.lastname: Fischbach
authors.forename: B
authors.initials: B
authors.lastname: Nuessle
authors.forename: G
authors.initials: G
authors.lastname: Rassner
mesh_terms: D005260:Female; D006801:Humans; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013724:Teratoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery