Combinatorial approach to selective multivalent ion pairing in mixed aqueous-organic media using bead-supported libraries of unnatural polyamines.
[structure: see text] Screening of a bead-supported encoded library of unnatural polyamines against model polyanionic targets (1 and 2) demonstrated that a combinatorial approach can highlight structural selectivity in multivalent ion pairing in aqueous solutions. This approach even provided -NH-2Acc(R)-6Ahx(R)-Et, a highly target-selective triamine sequence that can discriminate between two trisulfonated dyes displaying subtle structural differences.
Manku
Sukhdev
S
Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2 Canada.
Hall
Dennis G
DG
D000838:Anions; D001391:Azo Compounds / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004396:Coloring Agents; D020650:Combinatorial Chemistry Techniques; D008863:Microspheres; D009282:Naphthalenesulfonates / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D012996:Solutions; D014867:Water
D000838:Anions; D001391:Azo Compounds; D004396:Coloring Agents; D009282:Naphthalenesulfonates; D011073:Polyamines; D012996:Solutions; D014867:Water