title: von Willebrand disease in China.
abstract: OBJECTIVE
  To review the molecular pathogenesis in Chinese patients with von Willebrand disease (vWD) and polymorphisms of von Willebrand factor (vWF) in Chinese population.
  
  
  METHODS
  Both Chinese and English language literature search using MEDLINE (1985-1998), and original articles published in main Chinese and international journals.
  
  
  METHODS
  After reviewing of the literature, 19 articles of them were selected that specifically addressed the stated purpose.
  
  
  RESULTS
  The molecular pathogenesis of vWD was variant. Six cases of point mutation have been found in Chinese patients with vWD. The system of site-directed mutagenesis and expression of vWF gene was constructed. The polymorphisms of vWF gene are very different between Chinese and Gaucasians.
  
  
  CONCLUSIONS
  Combining to gene mutant in vWD patients, the use of site- directed mutagenesis and expression of vWF will help to understand the vWF function. The polymorphisms of vWF gene are useful marker in Chinese for carrier detection and prenatal diagnosis of vWD.
authors.affiliation: First Affiliated Hospital of Suzhou Medical College, Thrombosis and Hemostasis Research Unit, Jiangsu Institute of Hematology, Suzhou 215006, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Gu
authors.forename: C
authors.initials: C
authors.lastname: Ruan
mesh_terms: D006801:Humans; D009154:Mutation; D017354:Point Mutation; D011110:Polymorphism, Genetic; D014842:von Willebrand Diseases / Q000145:classification / Q000235:genetics*