The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke.
The authors investigated whether the lack of effect of tirilazad on clinical outcome in patients with acute ischemic stroke is explained by failure of tirilazad to reduce infarct volume. Overall, tirilazad had no significant effect on infarct volume. In the subgroups of male patients and of those with a cortical infarct, tirilazad significantly reduced infarct volume. These effects were reduced to nonsignificant trends after adjustment for imbalances in baseline characteristics. In conclusion, early treatment of patients with tirilazad has no effect on infarct volume.
van der Worp
H B
HB
Department of Neurology, University Medical Center, Utrecht, The Netherlands. h.b.vanderworp@neuro.azu.nl
Kappelle
L J
LJ
Algra
A
A
Bär
P R
PR
Orgogozo
J M
JM
Ringelstein
E B
EB
Bath
P M W
PM
van Gijn
J
J
D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011281:Pregnatrienes / Q000627:therapeutic use*; D016037:Single-Blind Method
D018696:Neuroprotective Agents; D011281:Pregnatrienes; C053355:tirilazad