title: Use of isotopes and LC-MS-ESI-TOF for mechanistic studies of tienilic acid metabolic activation.
authors.affiliation: Université René Descartes, CNRS UMR 8601 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Belghazi
authors.forename: P
authors.initials: P
authors.lastname: Jean
authors.forename: S
authors.initials: S
authors.lastname: Poli
authors.forename: J M
authors.initials: JM
authors.lastname: Schmitter
authors.forename: D
authors.initials: D
authors.lastname: Mansuy
authors.forename: P M
authors.initials: PM
authors.lastname: Dansette
mesh_terms: D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D002851:Chromatography, High Pressure Liquid; D002994:Clofibrate / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D007553:Isotope Labeling; D008862:Microsomes, Liver / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D012997:Solvents; D039181:Steroid 16-alpha-Hydroxylase; D013250:Steroid Hydroxylases / Q000378:metabolism*; D013989:Ticrynafen / Q000378:metabolism*; D014528:Uricosuric Agents / Q000378:metabolism*; D014867:Water / Q000378:metabolism; D015003:Yeasts
chemical_list: D012997:Solvents; D014528:Uricosuric Agents; D014867:Water; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C082185:CYP2C18 protein, human; D039181:Steroid 16-alpha-Hydroxylase; D013989:Ticrynafen; D002994:Clofibrate; D010100:Oxygen