Concurrent flavin-containing monooxygenase down regulation and cytochrome P450 induction by dietary indoles in the rat: implication for drug-drug interactions.
Williams
D E
DE
Department of Environmental and Molecular Toxicology and the Linus Pauling Institute, Oregon State University, Corvallis 97331, USA.
Katchamar
S
S
Larsen-Su
S A
SA
Stresser
D M
DM
Dehal
S S
SS
Kupfer
D
D
D000814:Aniline Compounds / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000378:metabolism*; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism*; D015536:Down-Regulation; D004347:Drug Interactions; D004790:Enzyme Induction; D007211:Indoles / Q000008:administration & dosage / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009538:Nicotine / Q000008:administration & dosage / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D013629:Tamoxifen / Q000008:administration & dosage / Q000378:metabolism
D000814:Aniline Compounds; D016588:Anticarcinogenic Agents; D007211:Indoles; D013629:Tamoxifen; D009538:Nicotine; C015157:N,N-dimethylaniline; C016517:indole-3-carbinol; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming); D019363:Cytochrome P-450 CYP1A1; C016392:3,3'-diindolylmethane