title: Influence of host factors on immunoglobulin G concentration in oral fluid specimens.
abstract: The influence of host factors (tobacco use, dentition, bleeding gums, oral rinsing, nasal medications, and time since the last meal) on immunoglobulin G (IgG) concentration in oral fluids (OF) was determined by univariate and multivariate analysis. Significant differences in IgG concentration were found to be associated with human immunodeficiency virus (HIV) status (HIV antibody positive, +16.60 microg/ml, P = 0.0001), sex (female, +1.23 microg/ml, P = 0.004), dentition (+2.83 microg/ml, edentulous versus dentulous, P = 0.0001), bleeding gums (+6.35 microg/ml, P = 0.0001), and time since the last meal (+3.55 microg/ml, >6 h, P = 0.0001). These factors could impact diagnostic methods that rely on the immunoglobulin concentration in OF specimens.
authors.affiliation: Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road D-12, Atlanta, GA 30333, USA. TGranade@cdc.gov
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Granade
authors.forename: Susan K
authors.initials: SK
authors.lastname: Phillips
authors.forename: Wendy
authors.initials: W
authors.lastname: Kitson-Piggott
authors.forename: Perry
authors.initials: P
authors.lastname: Gomez
authors.forename: Bisram
authors.initials: B
authors.lastname: Mahabir
authors.forename: Herbert
authors.initials: H
authors.lastname: Oleander
authors.forename: J Richard
authors.initials: JR
authors.lastname: George
authors.forename: James
authors.initials: J
authors.lastname: Baggs
authors.forename: Bharat
authors.initials: B
authors.lastname: Parekh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003817:Dentition; D005260:Female; D015658:HIV Infections / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000276:immunology*; D009067:Mouthwashes; D015999:Multivariate Analysis; D010510:Periodontal Diseases / Q000276:immunology; D012907:Smoking / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D009067:Mouthwashes