[Research and application of drug controlled release technique in tissue engineering].
OBJECTIVE
To investigate protection of biological activity and controlled release of growth factor by means of drug controlled release technique in tissue engineering.


METHODS
Using drug controlled release technique that to embed or microcapsulate the biological drug with biodegradable polymer.


RESULTS
The aliphatic polylactone could be used as drug carrier for each drug including the biological matter. And the release behavior of the drug could be controlled by adjusting the molecular structure of the carrier and the controlled release method. The successful example, that to realize regeneration of rat's sciatic nerve with 5, 10, 15 and 20 mm of gap by using polylactide as nerve guide and the embedding growth factor, had been obtained.


CONCLUSIONS
It is possible to realize protection of biological activity and sustained release of growth factor by using aliphatic polylactone as drug carrier.
Wang
S G
SG
Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P.R. China 100080.
Cai
Q
Q
Lü
Z
Z
D000241:Adenosine / Q000008:administration & dosage; D000818:Animals; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006133:Growth Substances / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007328:Insulin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D011108:Polymers / Q000008:administration & dosage; D051381:Rats; D023822:Tissue Engineering
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006133:Growth Substances; D007328:Insulin; D011108:Polymers; C069424:polyadenosine; D000241:Adenosine