title: High frequency loss of heterozygosity in the region of the DBH locus in bladder cancer.
abstract: OBJECTIVE
  To determine the location of a putative tumor suppressor gene (TSG), and evaluate the frequency loss of heterozygosity (LOH) of the long arm of chromosome 9 (9q) in bladder cancer.
  
  
  METHODS
  We analyzed 25 patients with bladder cancer for LOH of 9q using 25 high-density microsatellite markers.
  
  
  RESULTS
  Twenty-three samples (92%) showed LOH at least at one locus on 9q. We identified that the commonly deleted region were at 9q12-q21, 9q22, and 9q34. The rate of LOH was 44.0%, 22.7%, 22.7%, 16.0%, 12.0% on DBH, D9S15, D9S1815, D9S1831, D9S176 locus, respectively, and was not significantly related with grades and stages of tumor.
  
  
  CONCLUSIONS
  These data suggest that alteration of a TSG at DBH of 9q may play an important role in the development of bladder cancer.
authors.affiliation: Department of Urology, First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China.
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.forename: P
authors.initials: P
authors.lastname: Shen
authors.forename: K
authors.initials: K
authors.lastname: Yao
authors.forename: Z
authors.initials: Z
authors.lastname: Mi
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Liu
mesh_terms: D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm