The lectin-binding properties of six generations of mannose-functionalized dendrimers.
[structure: see text] First- through sixth-generation PAMAM dendrimers have been functionalized with mannose residues. Characterization with MALDI-TOF MS and (1)H NMR is reported. Different binding enhancements consistent with monovalent interaction, glycoside clustering, and multivalent binding are observed for different generations of dendrimers.
Woller
Eric K
EK
Department of Chemistry and Biochemistry, 108 Gaines Hall, Montana State University, Bozeman, Montana 59717, USA.
Cloninger
Mary J
MJ
D000818:Animals; D003208:Concanavalin A / Q000737:chemistry*; D050091:Dendrimers; D006386:Hemagglutination Tests; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008358:Mannose / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D011108:Polymers; D011817:Rabbits; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D011108:Polymers; D003208:Concanavalin A; D008358:Mannose