The effect of taurine derivative on lipid peroxidation and interhemispheric asymmetry of phospholipids from the brain synaptosomes in rats after immobilization stress.
Malondialdehyde (MDA) as an indicator of lipid peroxidation (LPO), content and composition of phospholipids (PL) were analyzed in synaptosomes of the rat brain hemispheres using immobilization stress without and with pretreatment with a new synthetic taurine derivative (STD). The stress was accompanied by a decrease MDA content, inversion of the initial asymmetry of total phospholipids (TPL) and modification PL composition in the brain hemispheres of rats. STD administration to the rats after stress antagonized the decrease of the MDA level, attenuates stress induced inversion TPL asymmetry and normalized PL composition in the brain hemispheres. Prevention or diminution of synaptosomal PL changes in the rat brain hemispheres are interpreted as one of the possible mechanisms of the neuroprotective effect of STD.
Novoselova
N Y
NY
Department of Comparative Neurochemistry, Institute of Evolutionary Physiology & Biochemistry, RAS, St-Petersburg, Russia.
Sapronov
N S
NS
Fedotova
Y O
YO
Torkounov
P A
PA
D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D007103:Immobilization; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives*
D015415:Biomarkers; D010743:Phospholipids; D013654:Taurine; D008315:Malondialdehyde