Ischemia-induced changes in synaptoarchitectonics of brain cortex and their correction with ascovertin and Leuzea extract.
Peroral administration of 70 mg/kg ascovertin and 150 mg/kg Leuzea extract to rats with cerebral ischemia for 5 days prevented destructive changes and decrease in the density of synapses in the cerebral cortex. These preparations activated compensatory and reparative mechanisms underlying plasticity of the synaptic pool, which was realized through hypertrophy and destruction of synaptic contacts. Ascovertin possessed more pronounced cerebroprotective activity than Leuzea extract.
Logvinov
S V
SV
Siberian State Medical University. s_logvinov@mail.ru
Pugachenko
N V
NV
Potapov
A V
AV
Krasnov
E A
EA
Plotnikov
M B
MB
Maslov
M Y
MY
Aliev
O I
OI
Tyukavkina
N A
NA
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004338:Drug Combinations; D005260:Female; D006984:Hypertrophy; D007511:Ischemia / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects / Q000473:pathology*
D004338:Drug Combinations; D010936:Plant Extracts; D011794:Quercetin; D001205:Ascorbic Acid