Thymidylate synthase inhibition induces p53 dependent and independent cell death.
Backus
H H
HH
Department of Oncology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Wouters
D
D
van der Wilt
C L
CL
Kuiper
C M
CM
van Groeningen
C J
CJ
Pinedo
H M
HM
Peters
G J
GJ
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D017209:Apoptosis; D053148:Caspase 3; D020169:Caspases / Q000096:biosynthesis; D003110:Colonic Neoplasms; D004249:DNA Damage; D004791:Enzyme Inhibitors / Q000494:pharmacology; D053222:Fas Ligand Protein; D005472:Fluorouracil / Q000494:pharmacology; D005493:Folic Acid Antagonists / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D006147:Guanine / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D000068437:Pemetrexed; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011799:Quinazolines / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D000964:Antimetabolites, Antineoplastic; D004791:Enzyme Inhibitors; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D005493:Folic Acid Antagonists; D005971:Glutamates; D008562:Membrane Glycoproteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011799:Quinazolines; D013876:Thiophenes; D016159:Tumor Suppressor Protein p53; D000068437:Pemetrexed; D006147:Guanine; D013940:Thymidylate Synthase; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases; C068874:raltitrexed; C099178:nolatrexed; D005472:Fluorouracil