Catalytic control of redox reactivities of coenzyme analogs by metal ions.
Redox coenzymes and analogs have their own redox reactivities for both thermal and photochemical redox reactions. The redox activities of coenzymes can be tuned by using metal ions that can bind the redox coenzymes and analogs. Quantitative measure to determine the Lewis acidity of a variety of metal ions is given in relation to the catalytic reactivities. The mechanistic viability of metal ion catalysis in redox reactions of coenzyme analogs is described by showing a number of examples of both thermal and photochemical reactions that are made possible to proceed by controlling the redox reactivities of coenzymes with metal ions.
Fukuzumi
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Department of Material and Life Science, Graduate School of Engineering, Osaka University, CREST, JAPAN Science and Technology Corporation, Suita. fukuzmi@ap.chem.eng.osaka-u.ac.jp
Itoh
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D002384:Catalysis; D005415:Flavins / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D045563:Indolequinones; D007477:Ions; D008956:Models, Chemical; D008958:Models, Molecular; D010084:Oxidation-Reduction; D011809:Quinones / Q000737:chemistry; D013482:Superoxide Dismutase / Q000737:chemistry; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000737:chemistry
D005415:Flavins; D045563:Indolequinones; D007477:Ions; D011809:Quinones; C070569:tryptophan tryptophylquinone; D006859:Hydrogen; D014364:Tryptophan; D013482:Superoxide Dismutase