Soluble adhesion molecules versus lymphoblast transformation in diagnosis of zoonotic cutaneous leishmaniasis.
Twelve parasitologically proven ZCL patients (one with non-ulcerative lesion and eleven with multiple ulcerative lesions) were subjected to estimation of the levels of lymphoblast transformation (LTT) and soluble adhesion molecules (sICAM-1 & sELAM-1 by ELISA). The results proved high percentage of LTT in relation to number and clinical picture of the ZCL lesions. As to the soluble adhesion molecules, sICAM-1 levels were significantly increased than in normal controls and correlated positively with the number of ulcerative lesions. sELAM-1 levels were not significantly increased than the normal controls, but correlated positively with the number of ulcerative lesions. Consequently, soluble adhesion molecules mainly sICAM-1 is a good marker of endothelial damage in ZCL as related to number and clinical type of lesions.
Morsy
T A
TA
Department of Parasitology, Faculty of Medicine, Universitiy of Ain Shams, Egypt.
el-Shazly
A M
AM
Nagaty
I M
IM
Maboud
A I
AI
D000818:Animals; D015815:Cell Adhesion Molecules / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis* / Q000469:parasitology; D008213:Lymphocyte Activation; D008297:Male; D012995:Solubility; D015047:Zoonoses
D015815:Cell Adhesion Molecules