title: [Renal dysfunction in chemical plant workers producing dust pesticides].
abstract: The study covered workers of a chemical plant producing dust pesticides. A study group included 24 men, aged 29-54 years, employed directly in the production, and 22 women, aged 31-52 years, performing auxiliary jobs and handling only closed packages. In order to assess the renal function in the workers, the concentrations of serum creatinine and uric acid, protein, albumin and alpha 1-microglobulin, as well as the activity of alkaline phosphatase (AP) and N-acetyl-beta-glucosaminidase (NAG) in urine were determined. The average air dust concentration at the workplaces was 0.42-16.66 mg/m3. The active substances with concentrations ranging from 10 to 75% in the final product were as follows: triazines, dithiocarbamates, carbendazim and thiophanate-methyl, captan, phenylureas, cupric oxychloride and occasionally also carbamates, dodine and 2,4-D. As compared to the results in the control groups of 31 healthy men and 22 women, free from occupational exposure to chemical noxas, a significantly higher serum creatinine concentration (in none of the subjects creatinine concentration exceeded the upper normal limit) and higher urinary protein, albumin and alpha 1-microglobulin concentrations, and higher enzyme activity were found in men, while in women only urine enzyme activity was significantly increased. The results speak in support of a discreet subclinical kidney impairment.
authors.affiliation: Kliniki Chorób Wewnetrznych i Farmakologii Klinicznej, Slaskiej Akademii Medycznej w Katowicach.
authors.forename: S
authors.initials: S
authors.lastname: Kossmann
authors.forename: J
authors.initials: J
authors.lastname: Tustanowski
authors.forename: B
authors.initials: B
authors.lastname: Kołodziej
mesh_terms: D000328:Adult; D002617:Chemical Industry; D004391:Dust; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D010573:Pesticide Residues / Q000009:adverse effects*
chemical_list: D004391:Dust; D010573:Pesticide Residues
vernacular_title: Dysfunkcja nerek u pracowników zakładu chemicznego produkujacych pyliste środki ochrony roślin.