title: HLA class II associated risk and protection against multiple sclerosis-a Finnish family study.
abstract: We analyzed the HLA class II haplotypes in 249 Finnish nuclear families and compared the frequencies of parental haplotypes transmitted or non-transmitted to multiple sclerosis (MS) patients. The most important predisposing haplotype was DRB1*15-DQB1*0602 (P<10(-6)) as expected and a weak predisposing effect of DRB1*04-DQB1*0302 was revealed after the elimination of DRB1*15-DQB1*0602. HLA-DRB1*01-DQB1*0501 and DRB1*13-DQB1*0603 were negatively associated with MS in transmission disequilibrium test, but only the DRB1*13-DQB1*0603 association remained significant (P=0.008) after the elimination of DRB1*15-DQB1*0602 haplotypes. Based on this study HLA class II haplotypes exhibit both predisposing and protective effects in MS.
authors.affiliation: Turku Immunology Centre and Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN-20520, Turku, Finland.
authors.forename: Mikko
authors.initials: M
authors.lastname: Laaksonen
authors.forename: Tomi
authors.initials: T
authors.lastname: Pastinen
authors.forename: Minna
authors.initials: M
authors.lastname: Sjöroos
authors.forename: Satu
authors.initials: S
authors.lastname: Kuokkanen
authors.forename: Juhani
authors.initials: J
authors.lastname: Ruutiainen
authors.forename: Marja Liisa
authors.initials: ML
authors.lastname: Sumelahti
authors.forename: Helena
authors.initials: H
authors.lastname: Reijonen
authors.forename: Reijo
authors.initials: R
authors.lastname: Salonen
authors.forename: Juhani
authors.initials: J
authors.lastname: Wikström
authors.forename: Martin
authors.initials: M
authors.lastname: Panelius
authors.forename: Jukka
authors.initials: J
authors.lastname: Partanen
authors.forename: Pentti J
authors.initials: PJ
authors.lastname: Tienari
authors.forename: Jorma
authors.initials: J
authors.lastname: Ilonen
mesh_terms: D005192:Family Health; D005387:Finland / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II