title: Vestibular schwannoma: negative growth and audiovestibular features.
abstract: At the University Medical Center Utrecht, non-operative management was used for 44 patients with a unilateral vestibular schwannoma between 1990 and 1997. During that period, consecutive tumor sizes were determined by magnetic resonance imaging. Three of the 44 patients showed an average decrease in tumor size of 16.7% according to American Academy of Otolaryngology-Head and Neck Surgery standards. This study describes the initial vestibular status and audiometric changes measured over up to 10 years in these three patients. Vestibular function was determined once, by means of the bithermal caloric test, the torsion test, the saccade test, the smooth pursuit test, and the registration of spontaneous nystagmus. The three patients had severe vestibular paresis on the affected side. Pure-tone and speech audiometry were performed at regular intervals. Although the size of their tumors decreased, their hearing gradually deteriorated, just as it does in the majority of patients with a growing or stable vestibular schwannoma. The observations presented here suggest that the development of symptoms in a vestibular schwannoma does not differentiate between patients with a stable, growing or shrinking tumor. The development of symptoms may be the result of the same pathogenetic mechanism.
authors.affiliation: Department of Otorhinolaryngology, University Medical Center Utrecht, The Netherlands. j.wissmann@planet.nl
authors.forename: E M
authors.initials: EM
authors.lastname: Stipkovits
authors.forename: K
authors.initials: K
authors.lastname: Graamans
authors.forename: J E
authors.initials: JE
authors.lastname: Van Dijk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001299:Audiometry; D003390:Cranial Nerve Neoplasms / Q000150:complications / Q000473:pathology*; D018450:Disease Progression; D004584:Electronystagmography; D005260:Female; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009464:Neuroma, Acoustic / Q000150:complications / Q000473:pathology*