title: [Surveillance of primary resistance in 481 cases of pulmonary tuberculosis].
abstract: OBJECTIVE
  To understand the primary resistance of Mycobacterium tuberculosis in Henan province, and to make scientific prophylactic and treatment strategies.
  
  
  METHODS
  Drug resistance surveillance (DRS) was implemented in Henan province according to WHO/IUATLD Guidelines for Surveillance of Drug Resistance in Tuberculosis(1994), and proportional method was used to detect primary resistance in 481 new cases of bacillus-positive pulmonary tuberculosis without history of anti-tuberculosis drug use.
  
  
  RESULTS
  The primary drug resistance(PDR) rates were 22.7%, 15.8%, 22.7% and 7.7% for INH, RFP, SM and EMB, respectively. The primary multi-drug resistance (MDR) rates were 2.3%, 5.0%, 0.4% and 5.4% for HR, HRS, HRE and HRSE, respectively.
  
  
  CONCLUSIONS
  The results show that the problem of primary resistance of Mycobacterium tuberculosis is serious in Henan province, and uniform management of anti-tuberculosis drugs and implementation of DOTs are needed.
authors.affiliation: Henan Anti-Tuberculosis Institute, Zhengzhou 450003.
authors.forename: X
authors.initials: X
authors.lastname: Zhen
authors.forename: L
authors.initials: L
authors.lastname: Yao
authors.forename: Y
authors.initials: Y
authors.lastname: Peng
mesh_terms: D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D011159:Population Surveillance; D014397:Tuberculosis, Pulmonary / Q000382:microbiology*