[Basaloid squamous cell carcinoma: clinical pathological and immunohistochemical study].
OBJECTIVE
To investigate the clinicopathological and immunohistochemical characteristics of basaloid squamous cell carcinoma of oral cavity.


METHODS
Routine HE staining and immunohistochemical staining.


RESULTS
Basaloid squamous cell carcinoma accounted for 1% of oral squamous cell carcinoma and was more common in male. It could be found at anysite of oral mucosa. The tumor was composed of basaloid cells and squamous cells. Basaloid cell, the main tumor cell, arranged in sheets and nests. Mitosis and comedoform necrosis was often seen. Adjacent oral epithelium often exhibited dysplasia. The tumor cells were cytokeratin positive, S-100 negative; PCNA index was high; 50% cases were p53 positive.


CONCLUSIONS
Oral basaloid squamous cell carcinoma was a higher grade malignant tumor as compared with usual squamous cell carcinoma and should be paid great attention both in treatment and in pathological diagnosis.
Gao
Y
Y
School of Stomatology, Beijing Medical University, Beijing 100081.
Liu
X
X
Pang
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D018809:Proliferating Cell Nuclear Antigen; D009418:S100 Proteins; D016159:Tumor Suppressor Protein p53