[Clinical and experimental study on effect of Shuguan granule on mid-late rheumatoid arthritis].
OBJECTIVE
To explore the therapeutic mechanism of Shuguan Granule (SGG) in treating mid-late rheumatoid arthritis.


METHODS
Based on the principle of reinforcing Kidney to treat arthritis, removing phlegm to remove stasis, two SGG, Shuguan Wenjing granule (SW) and Shuguan Qingluo granule (SQ) were prepared and used to treat mid-late 44 and 43 patients of rheumatoid arthritis respectively. The clinical result was compared with that of Wangbi Granule. Animal experiments on the effect of the two SGG were conducted.


RESULTS
The total effective rate of the SW, SQ and control group was 88.64%, 93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant-induced arthritis showed that the two SGG obviously raise the level of serum SOD, and lowered the levels of serum interleukin-1, plasma prostaglandin E2 and thromboxane B2, as compared with the model group, the difference was significant (P < 0.05, P < 0.01).


CONCLUSIONS
The two SGG have a comprehensive function of anti-inflammatory, analgesia, antioxidation, antihypercoagulation and immunoregulation.
Zhou
X
X
Nanjing University of TCM, Nanjing (210029).
Zhou
Z
Z
Jin
M
M
D000328:Adult; D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood / Q000188:drug therapy*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
D004365:Drugs, Chinese Herbal; D007074:Immunoglobulin G; D007375:Interleukin-1; D013929:Thromboxane B2; D013482:Superoxide Dismutase