Effects of hydrocortisone on peritoneal phagocytizing cells in rats under conditions of beta-adrenoceptors blockade.
Hydrocortisone decreased the count of peritoneal mononuclear phagocytes and mast cells and total phagocytic activity of peritoneal phagocytes in rats, but had no effect on the nitroblue tetrazolium test. beta-Adrenoceptor blockade abolished the suppressive effect of hydrocortisone on phagocytosis and prevented the decrease in the count of mast cells, but markedly reduced the number of neutrophils and parameters of stimulated nitroblue tetrazolium test.
Shilov
Y I
YI
Laboratory of Ecological Immunology, Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences. conf@ecology.psu.ru
Lanin
D V
DV
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010587:Phagocytosis; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013997:Time Factors
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D009580:Nitroblue Tetrazolium; D006854:Hydrocortisone