title: Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of alcohol and drug diagnoses.
abstract: The semi-structured diagnostic interview for genetic studies (DIGS) was developed to assess major mood and psychotic disorders and their spectrum manifestations in genetic studies. Our research group developed a French version of the DIGS and tested its inter-rater and test-retest reliability in psychiatric patients. In this article, we present estimates of the reliability of substance use and antisocial personality disorders. High kappa coefficients for inter-rater reliability were found for drug and alcohol as well as antisocial personality diagnoses and slightly lower kappas for test-retest reliability. Combined with evidence of the reliability of major mood and psychotic disorders, these findings support the suitability of the DIGS for studies of familial aggregation and comorbidity of psychiatric disorders including substance use and antisocial personality disorders.
authors.affiliation: University Department of Adult Psychiatry, Hôpital de Cery, CH-1008 Prilly-Lausanne, Switzerland.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Berney
authors.forename: Martin
authors.initials: M
authors.lastname: Preisig
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Matthey
authors.forename: François
authors.initials: F
authors.lastname: Ferrero
authors.forename: Brenda T
authors.initials: BT
authors.lastname: Fenton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology / Q000235:genetics*; D000987:Antisocial Personality Disorder / Q000453:epidemiology / Q000235:genetics; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000235:genetics*