[Chromosome locus of ATRA-induced gene RA109 and intracellular localization of RA109 protein].
OBJECTIVE
To define chromosome locus of ATRA-induced gene RA109 and intracellular localization of its encoding protein.


METHODS
Chromosome locus was defined by radiation hybrid mapping method and protein localization by green fluorescence protein (GFP) as reporter molecule.


RESULTS
RA109 gene was mapped to chromosome 5q35 and its protein was localized in cell nucleus.


CONCLUSIONS
RA109 gene is mapped by radiation hybrid technique to a chromosome region that is rich in disease-related genes. The RA 109-encoding protein is a nucleoprotein.
Zhao
J
J
National Laboratory of Molecular Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Liu
Z
Z
Wang
X
X
D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D049452:Green Fluorescent Proteins; D006801:Humans; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D009698:Nucleoproteins / Q000235:genetics* / Q000378:metabolism; D021101:Radiation Hybrid Mapping; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D008164:Luminescent Proteins; D009698:Nucleoproteins; D011993:Recombinant Fusion Proteins; D049452:Green Fluorescent Proteins; D014212:Tretinoin