Meiotic alterations in CAG repeat tracts.
We have investigated meiotic changes in CAG repeat tracts embedded in a yeast chromosome. Repeat tracts undergo either conversion events between homologs or expansion and contraction events that appear to be confined to a single chromatid. We did not find evidence for conversion of tract interruptions or excess exchange of flanking markers.
Schweitzer
J K
JK
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Reinke
S S
SS
Livingston
D M
DM
D015825:Chromosomes, Fungal; D003433:Crosses, Genetic; D003434:Crossing Over, Genetic; D005800:Genes, Fungal; D008540:Meiosis; D008957:Models, Genetic; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid; D012441:Saccharomyces cerevisiae / Q000235:genetics