Lymphocyte subsets in lung tissues of interstitial pneumonia associated with untreated polymyositis/dermatomyositis.
This study was designed to evaluate the distribution of lymphocyte subsets in lung specimens obtained by surgical lung biopsy from 12 patients with interstitial pneumonia associated with untreated polymyositis/dermatomyositis (PM/DM). Differences of histological findings and distributions of lymphocyte subsets between PM and DM were also evaluated. Distributions of B lymphocytes, CD4-positive T lymphocytes, and CD8-positive T lymphocytes were evaluated immunohistochemically. Interstitial pneumonia was pathologically classified as basically nonspecific interstitial pneumonia (NSIP) in all patients. Immunohistochemically, the distribution of B lymphocytes was mostly restricted to inside and/or around lymphoid follicles. The CD4-positive T lymphocytes were distributed diffusely in fibrotic areas and unrelated to lymphoid follicles. Most CD8-positive T lymphocytes were diffusely distributed, especially in relatively normal alveoli. There were no significant differences in the distribution of lymphocyte subsets between PM and DM. Although the distribution of B lymphocytes and CD4- and CD8-positive T lymphocytes in the lung were different, there were no significant differences in distributions of lymphocyte subsets between PM and DM.
Yamadori
I
I
Department of Clinical Pathology, National Okayama Medical Center, Japan.
Fujita
J
J
Kajitani
H
H
Bandoh
S
S
Tokuda
M
M
Ohtsuki
Y
Y
Yoshinouchi
T
T
Okahara
M
M
Yamaji
Y
Y
Tanimoto
Y
Y
Sato
Y
Y
Ishida
T
T
D000368:Aged; D001992:Bronchoalveolar Lavage Fluid; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D003882:Dermatomyositis / Q000097:blood / Q000473:pathology; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000473:pathology*; D016131:Lymphocyte Subsets / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000097:blood / Q000473:pathology