Expression of CD5 on hematogones in a 7-year-old girl with Shwachman-Diamond syndrome.
We report increased numbers of hematogones in a 7-year-old girl with pancytopenia due to Shwachman-Diamond syndrome. Her hematogones expressed the T-cell marker CD5 as well as CD19, CD10, and CD20, and terminal deoxynucleotidyl transferase and HLA-DR. These findings suggest that hematogones are precursors of both CD5-positive B cells and CD5-negative B cells. Thus CD5-positive B cells in bone marrow may be derived from bone marrow stem cells, and not from the residual fetal B cells of yolk sac/liver origin. The finding of CD5 expression on hematogones also raises the possibility that neoplastic B cells of chronic lymphocytic leukemia, which characteristically co-express CD5 and CD19, may be derived from CD5-positive B-cell precursors in bone marrow and not from mature B cells in lymph nodes.
Jelic
T M
TM
Department of Pathology, Charleston Area Medical Center, WV 25304, USA.
Raj
A B
AB
Jin
B
B
Kurczynski
E M
EM
Tolaymat
N
N
Chang
H H
HH
D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology; D018956:CD5 Antigens / Q000096:biosynthesis*; D002648:Child; D004253:DNA Nucleotidylexotransferase / Q000096:biosynthesis; D010188:Exocrine Pancreatic Insufficiency / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006130:Growth Disorders; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D010179:Pancreas / Q000000981:diagnostic imaging / Q000473:pathology; D013577:Syndrome; D014057:Tomography, X-Ray Computed
D018956:CD5 Antigens; D006684:HLA-DR Antigens; D004253:DNA Nucleotidylexotransferase