Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha. II.
Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabdane-type diterpenoid, compound 7 exhibited a remarkable inhibitory effect on EBV-EA induction, and a significant anti-tumor-promoting effect in the mouse two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanovl-phorbol-13-acetate.
Konoshima
T
T
Kyoto Pharmaceutical University, Japan. konosima@mb.kyoto-phu.ac.jp
Konishi
T
T
Takasaki
M
M
Yamazoe
K
K
Tokuda
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor / Q000379:methods / Q000706:statistics & numerical data; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000188:drug therapy; D008517:Phytotherapy / Q000379:methods; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts