[Changes on the protein kinase C activity of alveolar macrophages in patients with idiopathic pulmonary fibrosis].
OBJECTIVE
To study the changes on protein kinase C(PKC) activity of alveolar macrophages (AM) in patients with idiopathic pulmonary fibrosis(IPF).


METHODS
The PKC activity of AM in 9 healthy volunteers and 15 patients with IPF was investigated by radioactivity measuring.


RESULTS
The total, cytosolic and particulate fraction PKC activity of AM in bronchoalveolar lavage fluid(BALF) from patients with IPF were higher than those from control group(P < 0.01 and P < 0.05). The total and the membrane fraction PKC activity had positive correlation with the number of cells in BALF(r = 0.8135, P < 0.01 and r = 0.5917, P < 0.05) respectively.


CONCLUSIONS
As a bypass of transmembrane signal transduction, PKC was suggested to be involved in the development of IPF.
Liu
L
L
Institute of Respiratory Disease, China Medical University, Shenyang 110001, China.
Zong
Z
Z
Li
Z
Z
D000328:Adult; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D006801:Humans; D016676:Macrophages, Alveolar / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011493:Protein Kinase C / Q000378:metabolism*; D011658:Pulmonary Fibrosis / Q000201:enzymology*
D011493:Protein Kinase C