Gene therapy and pharmaceutical modulation of apoptosis.
Apoptosis is detectable in cardiovascular disease in various forms. Although the methods to detect apoptosis need improvement, and its magnitude is not known clearly, there is sufficient evidence to postulate that it might be important in progression of disease. Clinicians now have some specific compounds that can be used to modulate apoptosis. The preliminary data suggest that we can modulate apoptosis in animal models and that this is associated with obvious benefits in terms of tissue salvage and possibly improved function. There are no human data as yet. Many questions must be addresses before undertaking human studies. Despite these shortcomings, there is a tremendous potential for apoptotic modulation in preventing or ameliorating cardiovascular disease in the near future.
Chandrashekhar
Y
Y
Department of Medicine, University of Minnesota Medical School, Veterans Affairs Medical Center, Minneapolis, 55417, USA. shekh003@maroon.tc.umn.edu
Sen
S
S
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology* / Q000628:therapy*; D015316:Genetic Therapy; D006801:Humans; D051381:Rats; D013678:Technology, Pharmaceutical