Sequence analysis of the rat phenylalanine hydroxylase gene promoter.
We have characterized the 5'-end (3218 bp) of the rat phenylalanine hydroxylase (PAH) gene. Within this PAH promoter sequence, we have identified a number of putative regulatory sites analogous to those present in the human and murine PAH promoters. In particular, potential HNF 1 binding sites and a CRE have been identified. These sequences respectively bind HNF1 and CREB transcription factors present in rat nuclear extracts and may be significant in the tissue-specific and hormonal control of PAH expression.
Rees
D
D
Department of Biological Sciences, Chester College of Higher Education, Chester, CH1 4BJ, UK.
Fisher
M J
MJ
McDowall
I L
IL
D024506:5' Flanking Region / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D008969:Molecular Sequence Data; D010651:Phenylalanine Hydroxylase / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D051381:Rats / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
D010651:Phenylalanine Hydroxylase