Treatment of chronic radiation ulcers with recombinant platelet-derived growth factor and a hydrophilic copolymer membrane.
We report on a 59-year-old woman suffering from cutaneous T-cell lymphoma of the mycosis fungoides type, who developed chronic ulcerating radiation dermatitis after total body electron beam irradiation with a cumulative dose of 36 Gy. The painful and easily bleeding ulcers could be markedly improved using a combined approach with topical platelet-derived growth factor gel and hydrophilic copolymer membranes.
Wollina
U
U
Department of Dermatology and Allergology, Friedrich-Schiller-University of Jena, Germany. Wollina-Uw@khdf.de
Liebold
K
K
Konrad
H
H
D001672:Biocompatible Materials; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage*; D011140:Polyurethanes / Q000494:pharmacology*; D011855:Radiodermatitis / Q000175:diagnosis / Q000628:therapy*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012883:Skin Ulcer / Q000209:etiology / Q000628:therapy*; D017768:Skin, Artificial; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
D001672:Biocompatible Materials; D010982:Platelet-Derived Growth Factor; D011140:Polyurethanes; C045685:omiderm