title: Economic evaluation of collagenase-containing ointment and hydrocolloid dressing in the treatment of pressure ulcers.
abstract: OBJECTIVE
  To evaluate the efficacy and cost effectiveness of two treatments of pressure sores on the heel: a collagenase-containing ointment and a hydrocolloid dressing.
  
  
  METHODS
  Study and cost data were collected prospectively in a randomised clinical trial in The Netherlands by counting the resource use for each patient until wound healing occurred.
  
  
  METHODS
  All 24 female study participants were inpatients from the same hospital with grade IV pressure sores on the heel following orthopaedic surgery.
  
  
  METHODS
  Two different treatment strategies were analysed: a collagenase-containing ointment (Novuxol) and a hydrocolloid dressing (Duoderm).
  
  
  CONCLUSIONS
  Hospital perspective.
  
  
  RESULTS
  The average costs per patient for treatment with the hydrocolloid dressing were about 5% higher than those with the collagenase-containing ointment. The treatment costs were similarly distributed within both groups, with 34% for materials and 66% for personnel. The cost-effectiveness analysis revealed that cost savings of 899 Dutch guilders (1998 values) per successfully treated patient could be expected using the collagenase-containing ointment instead of the hydrocolloid dressing. In addition, wound healing was achieved, on average, within a shorter time period with the collagenase treatment (10 weeks) compared with the hydrocolloid treatment (14 weeks). The robustness of the results were also tested using sensitivity analyses. These analyses served to confirm that collagenase treatment provides a better cost-effectiveness ratio than hydrocolloid treatment.
  
  
  CONCLUSIONS
  With regard to overall costs and costs per successfully treated patient, this study showed collagenase treatment to be more cost effective than the hydrocolloid treatment in patients with grade IV pressure sores on the heel and that the amount of time needed for wound healing was shorter.
authors.affiliation: Institute for Medical Outcome Research, Loerrach, Germany. elvira.mueller@imor.com
authors.forename: E
authors.initials: E
authors.lastname: Müller
authors.forename: M W
authors.initials: MW
authors.lastname: van Leen
authors.forename: R
authors.initials: R
authors.lastname: Bergemann
mesh_terms: D000368:Aged; D047070:Bandages, Hydrocolloid; D017364:Collagenases / Q000191:economics / Q000627:therapeutic use*; D003102:Colloids / Q000191:economics / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D005260:Female; D006760:Hospitalization / Q000191:economics; D006801:Humans; D009426:Netherlands; D009824:Ointments; D003668:Pressure Ulcer / Q000188:drug therapy* / Q000191:economics; D014945:Wound Healing / Q000187:drug effects
chemical_list: D003102:Colloids; D009824:Ointments; D017364:Collagenases