[Changes of the activities of ET-1 in the serum and BALF of ILD patients and their clinical significance].
OBJECTIVE
To evaluate the roles of the Endothelin-1 (ET-1) in pathogenesis of the patients with interstitial lung disease (ILD).


METHODS
The ET-1 activities in the serum and BALF from 10 patients with sarcoidosis, 7 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects non-smokers were determined using the radio-immunoassay.


RESULTS
In the activities of ET-1 in the serum and BALF in the patients with sarcoiosis (62 +/- 29 and 17.0 +/- 2.4) ng/L and in the IPF (77 +/- 71 and 10 +/- 3) ng/L. was higher than those in the normal control subjects (20 +/- 8 and 4.0 +/- 0.6) ng/L. The activities of ET-1 in serum was negative correlated with PaO2 (r = -0.538, P < 0.01). The level of ET-1 in the BALF of the patient was positive correlated with total cells in BALF (r = 0.649, P < 0.01). The levels of ET-1 in the BALF in the sarcoidosis was positive correlated with the percentage of lymphocyte (r = 0.712, P < 0.01) but in patients with IPF was positive correlated with the percentage of neutrophil (r = 0.813, P < 0.01).


CONCLUSIONS
ET-1 might play an important role in pathogenic of the patients with sarcoidosis and IPF. The levels of ET-1 can act as the markers of activity of disease.
Li
Z
Z
Institute of the Respiratory Disease, China Medical University, Shenyang 110001.
Xia
S
S
Hou
X
X
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count; D019332:Endothelin-1 / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D011658:Pulmonary Fibrosis / Q000097:blood / Q000378:metabolism*; D017565:Sarcoidosis, Pulmonary / Q000097:blood / Q000378:metabolism*
D019332:Endothelin-1