Preclinical trials of human erythrocyte superoxide dismutase injection.
OBJECTIVE
To assess the quality of human erythrocyte superoxide dismutase (SOD) injection reaching the official standard for its clinical uses.


METHODS
Human erythrocyte SOD injection prepared by McCord-Fridovich's method without column chromatography but with some modifications was used in preclinical trials, to observe the general pharmacology and pharmacodynamics of the product.


RESULTS
The quality of human erythrocyte SOD injection conformed to the official standard of a biological product, which was found to be non-toxic and did not have any effects on the central and autonomic nervous systems as well as cardiovascular and respiratory systems. The efficacy of anti-inflammation and promotion of immuno-regulation especially on carrageenan and adjuvant-induced polyarthritis were shown in animals.


CONCLUSIONS
Human erythrocyte SOD injection is appropriate for prophylactic and therapeutic uses in clinical trials.
Zhou
C
C
Institute of Applied Free Radical Biology and Medicine, Chengdu Military District, Chengdu 610214, China.
Fang
Y
Y
Jiang
D
D
Yang
S
S
Lu
X
X
Sui
J
J
Li
P
P
Ren
J
J
D000818:Animals; D004285:Dogs; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D007267:Injections; D008297:Male; D051379:Mice; D051381:Rats; D013482:Superoxide Dismutase / Q000097:blood* / Q000493:pharmacokinetics / Q000494:pharmacology
D013482:Superoxide Dismutase