Aneurysmal bone cyst of the nose with 17p13 involvement.
We report on a 6-year-old girl with a polypoid mass, filling up the entire right nasal cavity as shown on a magnetic resonance imaging scan. Histologically, the tumor had the characteristics of an aneurysmal bone cyst, which is extremely rare in this location. Cytogenetic analysis disclosed a single (6:17)(p21;p13) translocation, confirming a specific genetic involvement in the development of aneurysmal bone cysts. Fluorescent in situ hybridization analysis mapped the putative gene between the p53 (17p13.1) and the Mieller-Dieker gene (17p13.3) loci.
Winnepenninckx
V
V
University Hospital St-Raphael, Department of Pathology, Katholieke Universiteit Leuven, Belgium.
Debiec-Rychter
M
M
Jorissen
M
M
Bogaerts
S
S
Sciot
R
R
D017824:Bone Cysts, Aneurysmal / Q000235:genetics* / Q000473:pathology; D002648:Child; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008279:Magnetic Resonance Imaging; D010254:Paranasal Sinus Diseases / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic