[Effects of shenmai injection on plasma neuropeptide Y, endothelin and atrial natriuretic polypeptide in heart failure patients].
OBJECTIVE
To investigate the effect of Shenmai injection (SMI) on neuroendocrine function in the patients with heart failure (HF).


METHODS
Sixty patients with HF were randomly divided into the treated group administered with SMI combined with western medicine, and the control group administered with western medicine alone. The change of cardiac function was observed, and plasma neuropeptide Y (NPY), endothelin (ET) and atrial natriuretic polypeptide (ANP) were determined by immunoradiometric assay.


RESULTS
The total effective rate and markedly effective rate were higher in the treated group than that of the control group, the level of NPY, ET and ANP of both groups were higher than healthy subjects. The plasma NPY, ET and ANP of both groups were significantly reduced after treatment, the effect of treated group was better than that of control group.


CONCLUSIONS
SMI could improve the HF patient's cardiac function, reduce the level of plasma NPY, ET and ANP, their neuroendocrine activity was affected at the same time.
Wu
H
H
Beijing Integrated Traditional and Western Medicine Hospital, Beijing (100039).
Lu
Y
Y
Zhang
Q
Q
D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood; D003327:Coronary Disease / Q000150:complications; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood*
D004365:Drugs, Chinese Herbal; D016232:Endothelins; D009478:Neuropeptide Y; D009320:Atrial Natriuretic Factor