title: Metabolism, endocrine status, and allergy in the extreme north.
abstract: The problem of allergic diseases has become more and more pressing in recent years, owing to a broad prevalence and constant morbidity growth in whole world, especially in high latitude regions. The present allergy situation in polar regions, especially in active industrial assimilation centres, undoubtedly stipulates necessity of a careful analysis of its forming mechanism and a search for effective methods of prevention and correction of allergic disorders. Our studies have revealed the significant influence of ecologically stipulated endocrine status modification on frequency of allergic disorders in the north. However, the character of the immune system and liver function in the case of blood cortisol increase has not allowed us to link allergic reactions with corticosteroid production by activation of the adrenal glands. Allergies in the north are mostly dependent on the influence of insulin and thyroid hormones. As it appears, allergies occur mainly among persons with a higher insulin level. Combination of high blood insulin concentration with functional disorders of the digestive system increases the allergy frequency. A similar picture of allergy frequency dependence also emerges in thyroid hormones blood level evaluation. Generally our investigations allow us to make the conclusion that allergic disorders in migrants to northern territories are an indication of the exhaustion of the organism's reserve abilities and are mainly connected with disorders of the function of the gastrointestinal tract and liver, which are stipulated by extreme climate-geophysical conditions of the north including technogenous industrial contamination. This could probably be connected either to a reduction of gastrointestinal tract barrier function for exogenous allergens or to a decrease of metabolism velocity and the clearing of antigen substances by liver.
authors.affiliation: Scientific Center of Clinical and Experimental Medicine SB RAMS.
authors.forename: P V
authors.initials: PV
authors.lastname: Hasnulin
authors.forename: V G
authors.initials: VG
authors.lastname: Seliatitskaya
mesh_terms: D000328:Adult; D001110:Arctic Regions / Q000453:epidemiology; D004702:Endocrine Glands / Q000502:physiology*; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006967:Hypersensitivity / Q000453:epidemiology*; D007328:Insulin / Q000097:blood; D008297:Male; D012426:Russia / Q000453:epidemiology; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D007328:Insulin; D013963:Thyroid Hormones; D006854:Hydrocortisone