[Clinical and experimental study on treatment of asthma with juanxiao tablet].
OBJECTIVE
To evaluate the therapeutic effect of Juanxiao Tablet (JXT) in treating asthma.


METHODS
Clinical observation on 447 cases of asthma was done by double- or single-blind control method, and the therapeutic effect and safety of JXT were analysed. The effect of JXT in antiasthma, expectorant, antisepsis, hypoxia tolerance was studied, and its acute and chronic toxicity also examined.


RESULTS
The clinical control rate in patients treated with JXT was 38.2%, its markedly effective rate 31.2% and total effective rate 93.4%, while in patients treated with Oleum Vitex Negundo, the respective data were 13.3%, 20.0% and 68.5%. Results of pulmonary function and IgE measurement were consistent with clinical effect. Experimental study showed that the JXT has the action of anti-asthma, expectorant, antisepsis and hypoxia tolerance enhancement, its LD50 was (40.48 +/- 5.17) g/kg.


CONCLUSIONS
JXT is a new Chinese herbal preparation of good effect, less toxic-side reaction for asthma treatment.
Hong
G
G
Jiangxi College of TCM, Nanchang (330006).
Zhang
Y
Y
Huang
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D016037:Single-Blind Method
D018927:Anti-Asthmatic Agents; D004365:Drugs, Chinese Herbal