title: The "common cause hypothesis" of cognitive aging: evidence for not only a common factor but also specific associations of age with vision and grip strength in a cross-sectional analysis.
abstract: A prominent hypothesis in cognitive aging is the existence of a common factor that is responsible for age-related deterioration in cognitive and noncognitive processes. A multiple indicators, multiple causes model was used to examine the nature of this common factor and its relationship to age, gender, and the apolipoprotein E (APOE) genotype. The common factor was modeled by using 10 indicator variables with 374 participants aged between 77.4 and 98.7 years. A latent factor was identified, with all indicators except blood pressure loading significantly. This factor could be established in 2 age strata within the sample. After controlling for the effects of gender, APOE, and level of education, direct effects of age were seen on visual functioning and grip strength. APOE was significantly associated with memory but not with the common factor. The findings suggest that a number of specific processes may operate concurrently with any common cause factor.
authors.affiliation: Centre for Mental Health Research, Australian National University, Canberra, Australian Capital Territory, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Christensen
authors.forename: A J
authors.initials: AJ
authors.lastname: Mackinnon
authors.forename: A
authors.initials: A
authors.lastname: Korten
authors.forename: A F
authors.initials: AF
authors.lastname: Jorm
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001057:Apolipoproteins E / Q000235:genetics; D003072:Cognition Disorders / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D018737:Hand Strength; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011930:Reaction Time; D014786:Vision Disorders / Q000453:epidemiology*
chemical_list: D001057:Apolipoproteins E