2,2,2-trifluoroethyl formate: a versatile and selective reagent for the formylation of alcohols, amines, and N-hydroxylamines.
[reaction: see text] Treatment of a variety of alcohols, amines, and N-hydroxylamines with 2,2,2-trifluoroethyl formate gave the corresponding formylated adducts in high yields.
Hill
David R
DR
Abbott Laboratories, Global Pharmaceutical R&D, 1401 Sheridan Road, D-R450, Bldg. R8, North Chicago, Illinois 60064-4000, USA. david.hill@abbott.com
Hsiao
Chi-Nung
CN
Kurukulasuriya
Ravi
R
Wittenberger
Steven J
SJ
D000438:Alcohols / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D005561:Formates / Q000737:chemistry*; D006898:Hydroxylamines / Q000737:chemistry*; D007202:Indicators and Reagents; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis*
C446681:2,2,2-trifluoroethyl formate; D000438:Alcohols; D000588:Amines; D005561:Formates; D006898:Hydroxylamines; D007202:Indicators and Reagents; D011480:Protease Inhibitors; D008666:Metalloendopeptidases