Anti-fecundity immunity in mice immunized with anti-idiotypic monoclonal antibody NP30 of Schistosoma japonicum.
OBJECTIVE
To observe the effects of anti-fecundity and anti-embryonation immunity of anti-idiotypic monoclonal antibody NP30 of Schistosoma japonicum on female adult worm.


METHODS
The active immunization of C57BL/6 mice was conducted by means of three intraperitoneal injections of NP30. The control group was injected with SP2/0 ascites intraperitoneally.


RESULTS
On the twenty-seventh day after challenge infection, the number of eggs in the liver tissue and in uterus of the group immunized with NP30 decreased by 30.91% and by 38.55%, respectively. On the thirty-ninth day after the challenge infection, the number of mature eggs in the liver tissue of the group immunized with NP30 decreased by 66.63% and the number of dead eggs increased by 60.66%.


CONCLUSIONS
NP30, with which mice were actively immunized, possesses double effects of anti-fecundity and anti-embryonation immunity on female adult worm of Schistosoma japonicum, therefore it can be used as a promising candidate of anti-pathologic vaccine molecule against Schistosomiasis japonica.
Feng
Z
Z
Department of Parasitology, Nanjing Medical University, Nanjing 210029, China.
Li
Y
Y
Qiu
Z
Z
Li
Y
Y
Xue
W
W
Guan
X
X
Wu
G
G
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology*; D005260:Female; D005298:Fertility / Q000276:immunology*; D007114:Immunization; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010270:Parasite Egg Count; D012549:Schistosoma japonicum / Q000276:immunology*; D014599:Uterus / Q000469:parasitology; D014612:Vaccines / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D014612:Vaccines