[Autoregulation of coronary vessels following the acute blood loss and its combination with preexisting immobilization stress].
A 6-hour immobilization stress and a 2-hour posthaemorrhagic hypotension caused elevation of the coronary flow, deterioration of coronary autoregulation, decreasing of the coronary dilation reserve, and diminishing of the left ventricular pressure. In the "stress + haemorrhage" group, the changes of the coronary vessels autoregulation ability were less obvious. Concentration of NO3-/NO2- in the blood serum was elevated after stress. Inhibition of the NO-synthase decreased the coronary flow. Thereupon, a pre-existing immobilization stress alters the coronary vessels tone.
Solodkov
A P
AP
State Medical University, 210023, Vitebsk, Frunze Ave. 27, Belarus.
Beliaeva
L E
LE
Shebeko
V I
VI
D000818:Animals; D001775:Blood Circulation; D001810:Blood Volume; D003331:Coronary Vessels; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006706:Homeostasis; D007103:Immobilization; D066298:In Vitro Techniques; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009566:Nitrates / Q000097:blood; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D009573:Nitrites / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000503:physiopathology*; D018924:Vascular Capacitance; D017725:Ventricular Pressure
D004791:Enzyme Inhibitors; D009566:Nitrates; D009573:Nitrites; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester
Autoreguliatsiia koronarnykh sosudov posle ostroĭ krovopoteri i ee sochetanii s predvaritel'no perenesennym stressom.