[Effect of mexidol on clinical and biochemical parameters of perinatal hypoxia in newborn children].
A complex prospective clinical and biochemical study was carried out in a group of 252 children with perinatal encephalopathy in dynamics during the 1st year of their life. The state of the lipid peroxidation (LPO) process, antioxidant system, and the phospholipid content of thrombocyte membranes were studied. Activation of the LPO process and a decrease in the antioxidant resistance level were observed. The efficacy of the antioxidant drug mexidol in infants was investigated for intravenous drug administration in a daily dose of 0.1-0.2 ml/kg over a 10-day period. The results confirmed good efficacy of the antioxidant therapy with mexidol in children with perinatal CNS disturbances.
Levitina
E V
EV
Tyumen State Medical Academy, Ministry of Public Health of the Russian Federation, ul. Odesskaya 54, Tyumen, 625000 Russia.
D000975:Antioxidants / Q000627:therapeutic use*; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism; D007231:Infant, Newborn; D015227:Lipid Peroxidation / Q000187:drug effects; D010847:Picolines / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism; D012545:Schiff Bases / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D010847:Picolines; D012545:Schiff Bases; C070020:emoxypine succinate; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D013482:Superoxide Dismutase
Vliianie meksidola na kliniko-biokhimicheskie proiavleniia perinatal'noĭ gipoksii u novorozhdennykh deteĭ.