title: Rheumatological complications associated with the use of indinavir and other protease inhibitors.
abstract: Several cases are reported of rheumatological pathology (temporomandibular dysfunction, frozen shoulder, Dupuytren's disease, and tendinitis) most probably related to the intake of indinavir in HIV positive patients. A survey using an anonymous questionnaire of 878 people with HIV infection treated with antiretroviral drugs suggests that other protease inhibitors may also cause arthralgia.
authors.affiliation: Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Florence
authors.forename: W
authors.initials: W
authors.lastname: Schrooten
authors.forename: K
authors.initials: K
authors.lastname: Verdonck
authors.forename: C
authors.initials: C
authors.lastname: Dreezen
authors.forename: R
authors.initials: R
authors.lastname: Colebunders
mesh_terms: D000328:Adult; D004387:Dupuytren Contracture / Q000139:chemically induced; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000139:chemically induced*; D019534:Shoulder Impingement Syndrome / Q000139:chemically induced; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000139:chemically induced; D052256:Tendinopathy / Q000139:chemically induced
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir