r-hirudin as anticoagulant for cardiopulmonary bypass.
A 68-year-old woman with unstable angina and an episode of ventricular fibrillation developed a persistent and recurrent rash due to heparin. Medical therapy was continued with danaproid. For cardiopulmonary bypass and coronary artery grafting, r-hirudin was used as the anticoagulant. There were no thrombotic or coagulopathic complications. There is still no ideal alternative to unfractionated heparin for anticoagulation for cardiopulmonary bypass. The use of r-hirudin was successful and we describe our anticoagulant strategy.
Cameron
R J
RJ
Department of Anaesthesia, Waikato Hospital, Hamilton, New Zealand.
D000368:Aged; D000789:Angina, Unstable / Q000188:drug therapy / Q000209:etiology; D000925:Anticoagulants / Q000627:therapeutic use*; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications / Q000601:surgery; D005260:Female; D024764:Hirudin Therapy; D006629:Hirudins / Q000031:analogs & derivatives*; D006801:Humans; D011300:Preoperative Care; D011994:Recombinant Proteins / Q000627:therapeutic use*; D016896:Treatment Outcome
D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; C083544:lepirudin