[Endothelin-1 in coronary artery disease].
Endothelins (ETs) are the peptides made up of 21 amino acids synthesized and released by variety of cells. Following studies revealed three isoforms of ETs-ET-1, ET-2 and ET-3. Endothelin ET-1 is known as the most potent endothelium-derived vasoconstrictor peptide identified so far. Endothelin ET-1 acts in a paracrine manner on the two types of receptors ET-A and ET-B. The former is responsible for the vascular smooth muscle constriction and the latter for vasodilation or vasoconstriction depending on the subtype of this receptor (ET-B1 or ET-B2 respectively). Endothelin receptor subtypes have been demonstrated and pharmacologically characterized in the coronary vascular bed. A good deal of experimental and clinical data has been accumulated to support an important role of endothelin-1 in ischemic heart disease. In experimental animals, exogenous ET-1 was found to cause coronary vasoconstriction and, at higher doses, ventricular fibrillation and death. The plasma levels of immunoreactive endothelin-1 were found to be increased in patients with coronary arteriosclerosis, acute myocardial infarction, and angina. The purpose of this study was to critically review the experimental and clinical data supporting the involvement of ET-1 in ischemic heart disease.
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Katedra i Zakład Chemii i Biochemii Klinicznej Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu.
Kara-Perz
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Torliński
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D000818:Animals; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000503:physiopathology; D003331:Coronary Vessels / Q000378:metabolism* / Q000503:physiopathology; D019332:Endothelin-1 / Q000378:metabolism*; D006801:Humans; D017202:Myocardial Ischemia / Q000378:metabolism; D017466:Receptors, Endothelin / Q000378:metabolism*
D019332:Endothelin-1; D017466:Receptors, Endothelin
Endotelina-1 w chorobie niedokrwiennej serca.