[Effect of a novel antimigraine preparation tropoxin on EEG of MR and MNRA rats].
Effect of the new antimigraine drug tropoxin on the EEG profile was studied in MR and MNRA rats with genetically determined high and low levels of emotionality, respectively. In MR rats, tropoxin decreased the number of the bioelectric activity parameters changed by the stressor action (0.9% NaCl, i.p.). The drug reduced the spectral power in the EEG delta band, and increased that in the theta, beta-1, and beta-2 bands. This was evidence of the central stimulating action and the possible enhancement of the exploratory activity. In MNRA rats no changes in bioelectric activity were observed in the low-frequency delta and theta bands, while the spectral power in the beta-1, and beta-2 bands showed a decrease. It was concluded that a neural component is present in the mechanism of the tropoxin action, which may play an important part in the therapeutic effect of the new drug.
Kozhechkin
S N
SN
Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Seredenin
S B
SB
Mirzoian
R S
RS
Sviderskaia
N E
NE
Korol'kova
T A
TA
Koshtoiants
O Kh
OKh
Kozhedub
R G
RG
D000818:Animals; D001372:Aza Compounds / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D004569:Electroencephalography; D005838:Genotype; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012965:Sodium Chloride; D013045:Species Specificity; D013315:Stress, Psychological / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology; D014665:Vasodilator Agents / Q000494:pharmacology*
C114333:3-(3,4,5-trimethoxybenzoyloximino)-8-methyl-8-azabicyclo(3,2,1)octane; D001372:Aza Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D012702:Serotonin Antagonists; D014665:Vasodilator Agents; D012965:Sodium Chloride
Vliianie novogo protivomigrenevogo preparata tropoksina na EEG krys liniĭ MR i MNRA.