Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium.
We report a prolonged neuromuscular block with the nondepolarizing muscle relaxant rapacuronium in the presence of clindamycin. Even when using "short-acting" muscle relaxants, the anesthesiologist must routinely monitor the neuromuscular function.
Sloan
Paul A
PA
University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA. PaulSloan@prodigy.net
Rasul
Mazhar
M
D000328:Adult; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002585:Cesarean Section; D002981:Clindamycin / Q000494:pharmacology*; D004347:Drug Interactions; D004630:Emergencies; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008274:Magnesium / Q000494:pharmacology*; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents; D011247:Pregnancy; D013997:Time Factors; D014673:Vecuronium Bromide / Q000031:analogs & derivatives*
D000900:Anti-Bacterial Agents; D003473:Neuromuscular Nondepolarizing Agents; D002981:Clindamycin; D014673:Vecuronium Bromide; C082938:rapacuronium; D008274:Magnesium