NMDA antagonists inhibit the development of ethanol dependence in rats.
The influence of non-competitive NMDA receptor antagonist, 1-amino-3,5-dimethyl-adamantane (memantine), and glycineB site antagonist, 7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolone (L-701,324), on the development of ethanol dependence was investigated in Wistar rats. The development of ethanol dependence was induced by intragastric administration of 20% w/v ethanol, three times a day at increasing doses. The results were quantified using withdrawal audiogenic seizures, 12 h after the last ethanol administration. Memantine (3.75 or 7.5 mg/kg) and L-701,324 (2.5 or 5 mg/kg), given before ethanol administration, prevented the development of ethanol dependence. Our results support the data that NMDA receptors are involved in the development of ethanol dependence.
Kotlińska
J
J
Department of Pharmacodynamics, Medical University, Lublin, Poland.
D015763:2-Amino-5-phosphonovalerate / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000220:Adaptation, Biological; D019973:Alcohol-Related Disorders / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008559:Memantine / Q000008:administration & dosage / Q000627:therapeutic use*; D015363:Quinolones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012646:Self Administration
D018691:Excitatory Amino Acid Antagonists; D015363:Quinolones; D016194:Receptors, N-Methyl-D-Aspartate; D000431:Ethanol; D015763:2-Amino-5-phosphonovalerate; C094635:L 701324; D008559:Memantine