title: Carboxyhemoglobin levels in patients with sickle-cell anemia: relationship to hemolytic and vasoocclusive severity.
abstract: BACKGROUND
  When carbon monoxide binds to hemoglobin, it increases the affinity of hemoglobin for oxygen and shifts the oxygen dissociation curve to the left. The resulting decrease in sickling tendency could have clinical benefit, and carbon monoxide has been suggested as a treatment for sickle-cell disease. Furthermore, in sickle-cell disease, as in other hemolytic diseases, endogenous carbon monoxide production is increased because of increased heme catabolism.
  
  
  METHODS
  In the present study, we measured carboxyhemoglobin levels in sickle-cell patients and compared them with estimates of the hemolytic and the vasoocclusive severity of the disease.
  
  
  RESULTS
  Significant correlation was found between carboxyhemoglobin (HbCO) levels and hematocrit, reticulocyte count, unconjugated bilirubin level, and percentage of irreversibly sickled cells. However, there was no significant correlation between carboxyhemoglobin levels and measures of the vaso-occlusive severity of the disease.
  
  
  CONCLUSIONS
  The correlations between HbCO levels and measures of hemolytic severity are best explained by the known relationship between hemoglobin catabolism and CO production. The lack of correlation with vaso-occlusive severity may be due to the complex changes involved and the difficulty of quantifying vasoocclusive severity.
authors.affiliation: Department of Medicine, Baylor College of Medicine and Ben Taub General Hospital, Houston, Texas 77030, USA. dsears@bcm.tmc.edu
authors.forename: D A
authors.initials: DA
authors.lastname: Sears
authors.forename: M M
authors.initials: MM
authors.lastname: Udden
authors.forename: L J
authors.initials: LJ
authors.lastname: Thomas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000755:Anemia, Sickle Cell / Q000097:blood / Q000503:physiopathology*; D001663:Bilirubin / Q000097:blood; D002263:Carboxyhemoglobin / Q000032:analysis*; D004913:Erythrocytes, Abnormal / Q000166:cytology; D005260:Female; D006400:Hematocrit; D006461:Hemolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012156:Reticulocytes / Q000166:cytology; D012907:Smoking; D014652:Vascular Diseases / Q000503:physiopathology
chemical_list: D002263:Carboxyhemoglobin; D001663:Bilirubin