title: A model of radiation-induced myelopoiesis in space.
abstract: Astronauts' radiation exposure limits are based on experimental and epidemiological data obtained on Earth. It is assumed that radiation sensitivity remains the same in the extraterrestrial space. However, human radiosensitivity is dependent upon the response of the hematopoietic tissue to the radiation insult. It is well known that the immune system is affected by microgravity. We have developed a mathematical model of radiation-induced myelopoiesis which includes the effect of microgravity on bone marrow kinetics. It is assumed that cellular radiosensitivity is not modified by the space environment, but repopulation rates of stem and stromal cells are reduced as a function of time in weightlessness. A realistic model of the space radiation environment, including the HZE component, is used to simulate the radiation damage. A dedicated computer code was written and applied to solar particle events and to the mission to Mars. The results suggest that altered myelopoiesis and lymphopoiesis in microgravity might increase human radiosensitivity in space.
authors.affiliation: Department of Physics, University "Federico II", Dipartimento di Scienze Fisiche, Complesso universitario de Monte S. Angelo, Napoli, Italy.
authors.forename: R D
authors.initials: RD
authors.lastname: Esposito
authors.forename: M
authors.initials: M
authors.lastname: Durante
authors.forename: G
authors.initials: G
authors.lastname: Gialanella
authors.forename: G
authors.initials: G
authors.lastname: Grossi
authors.forename: M
authors.initials: M
authors.lastname: Pugliese
authors.forename: P
authors.initials: P
authors.lastname: Scampoli
authors.forename: T D
authors.initials: TD
authors.lastname: Jones
mesh_terms: D002470:Cell Survival / Q000528:radiation effects; D003359:Cosmic Radiation; D006412:Hematopoietic Stem Cells / Q000528:radiation effects; D006801:Humans; D019891:Leukopoiesis / Q000528:radiation effects*; D018499:Linear Energy Transfer; D018535:Mars; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced; D011835:Radiation Protection; D011836:Radiation Tolerance; D019445:Solar Activity; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*