title: Synthesis of substituted-(l)-tryptophanols from an enantiomerically pure aziridine-2-methanol.
abstract: Enantiomerically pure (l)-tryptophanol (5) was synthesized from 4(R)-iodomethyl-2-oxazolidinone (2) and indolylmagnesium bromide in three steps (52% overall yield). Using this procedure, we also prepared various tryptophanols with substituent(s) on the indole ring. Furthermore, optically active 4(R)-iodomethyl-2-oxazolidinone was readily prepared from an enantiomerically pure aziridine-2(S)-methanol in high yield. [reaction: see text]
authors.affiliation: Department of Chemistry, Sogang University, Seoul 121-742, Korea.
authors.forename: D K
authors.initials: DK
authors.lastname: Pyun
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Ha
authors.forename: C S
authors.initials: CS
authors.lastname: Park
authors.forename: J W
authors.initials: JW
authors.lastname: Chang
authors.forename: W K
authors.initials: WK
authors.lastname: Lee