title: [Prevention of postoperative scar processes in otorhinolaryngology experimental rationale].
abstract: It is shown in vitro that fibroblast proliferation may be inhibited by 5-fluorouracil (5-Fu). In stimulated growth of the fibroblasts the 5-Fu antiproliferative effect takes place even in minimal concentration (2 mcg/ml). Fibroblastic proliferative activity recovers after elimination of 5-Fu from the medium at concentration under 63 mcg/ml.
authors.forename: A I
authors.initials: AI
authors.lastname: Kriukov
authors.forename: S M
authors.initials: SM
authors.lastname: Sharkov
authors.forename: M N
authors.initials: MN
authors.lastname: Shubin
authors.forename: E A
authors.initials: EA
authors.lastname: Kalashnikova
authors.forename: R B
authors.initials: RB
authors.lastname: Khamzalieva
authors.forename: Sh M
authors.initials: ShM
authors.lastname: Akhmedov
mesh_terms: D000963:Antimetabolites / Q000494:pharmacology / Q000627:therapeutic use*; D002465:Cell Movement / Q000187:drug effects; D002921:Cicatrix / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control*; D004427:Ear Diseases / Q000601:surgery*; D005347:Fibroblasts / Q000187:drug effects* / Q000473:pathology*; D005472:Fluorouracil / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D013506:Otologic Surgical Procedures / Q000379:methods*; D010254:Paranasal Sinus Diseases / Q000601:surgery*; D011183:Postoperative Complications
chemical_list: D000963:Antimetabolites; D005472:Fluorouracil
vernacular_title: Eksperimental'noe obosnovanie profilaktiki posleoperatsionnykh rubtsovykh protsessov v otorinolaringologii.