title: [Pregnancy with Rh-isoimmunization. Results of a retrospective analysis in the maternity hospital "Maichin Dom"].
abstract: The aim of the study is to analyze the outcome of pregnancies complicated by Rh-isoimmunization for the period 1996-2001 and to outline the aspects of optimization of the obstetrical conduct.
  
  
  METHODS
  The current study includes 39 pregnant women with Rh-isoimmunisation to whom amniocentesis and cordocentesis was performed. All cases were analyzed using medical history, serology (indirect Coombs, PAP test), ultrasound examination, amniocentesis, cordocentesis, NST.
  
  
  RESULTS
  From 39 pregnancies, complicated by severe Rh-isoimmunization 36 resulted in a live delivery, 2 resulted in intrauterine death of the fetus and 1 in early neonatal death. The titre of the antibodies is of prognostical value only in the first isoimmunised pregnancy. In this case there is a reliable correlation between the condition of the newborn and the zone from the Liley curve, antenatally found. With history of former immune pregnancies with unfavourable perinatal outcome most precise information about the condition of the foetus gives the cordocentesis.
  
  
  CONCLUSIONS
  In all of the discussed cases the Rh-isoimmunization is a result of no andi-D immunoglobulin profilaxis post partum or following abortion. That is why the efforts should be directed towards conduction of proper profilaxis to all Rh-negative pregnant women.
authors.forename: V
authors.initials: V
authors.lastname: Mazneikova
authors.forename: V
authors.initials: V
authors.lastname: Dimitrova
authors.forename: Zh
authors.initials: Zh
authors.lastname: Karag'ozova
authors.forename: M
authors.initials: M
authors.lastname: Ivanova
authors.forename: E
authors.initials: E
authors.lastname: Mikhailova
authors.forename: A
authors.initials: A
authors.lastname: Stefanova
authors.forename: B
authors.initials: B
authors.lastname: Sl'ncheva
authors.forename: K
authors.initials: K
authors.lastname: Tsekova
authors.forename: S
authors.initials: S
authors.lastname: Lekova
authors.forename: Ts
authors.initials: Ts
authors.lastname: Furnadzhieva
mesh_terms: D001805:Blood Transfusion, Intrauterine; D002031:Bulgaria / Q000453:epidemiology; D005260:Female; D006801:Humans; D007072:Immunoglobulin D / Q000276:immunology* / Q000627:therapeutic use; D007231:Infant, Newborn; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D011256:Pregnancy Outcome; D017584:Reproductive History; D012189:Retrospective Studies; D012203:Rh Isoimmunization / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D007072:Immunoglobulin D
vernacular_title: Bremennost s Rh-izoimunizatsiia. Rezultati ot retrospektiven analiz v sbalag "Maichin Dom."