[Prevention and treatment of malaria: in vitro evaluation of new compounds].
One of the current options for reducing the morbidity and mortality of malaria are chemoprophylaxis and chemotherapy. For this reason, the increasing prevalence of strains of Plasmodium falciparum resistant to chloroquine and other antimalarial drugs poses a serious problem for control of malaria. There is an urgent need to find and develop novel compounds and to identify novel chemotherapeutic targets. Different approaches to discover new compounds are presented from examples of molecules studied in the Tropical Medicine Institute of the French Army Health Service (IMTSSA) evaluation against isolates of compounds in pharmaceutical development in collaboration with pharmaceuticals (pyronaridine, benflumetol, ferrochloroquine), screening of molecules which are still registered for other pathologies (antibiotics), screening of new synthesized compounds (artemisinin derivatives) and identification of parasitical targets and essential metabolic ways for parasite, and identification of molecules acting on these targets (reversal of resistance to chloroquine, iron chelators).
Pradines
B
B
Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Bd C. Livon, Parc le Pharo, BP 46, F13998 Marseille Armées.
Fusai
T
T
Rogier
C
C
Keundjian
A
A
Sinou
V
V
Merckx
A
A
Mosnier
J
J
Daries
W
W
Torrentino
M
M
Parzy
D
D
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000517:prevention & control* / Q000628:therapy*; D010963:Plasmodium falciparum / Q000187:drug effects
D000962:Antimalarials
Prophylaxie et traitement du paludisme: évaluation in vitro de nouveaux composés.