title: [Relationship between follicular development and insulin like growth factor I receptor in stimulated cycles].
abstract: OBJECTIVE
  To investigate the number of follicles and insulin-like growth factor I receptor (IGF-I R) in stimulated cycles.
  
  
  METHODS
  IGF-I R mRNA and IGF-I R in granulosa cells obtained during oocyte retrieval were respectively measured by reverse transcript polymerase chain reaction (RT-PCR) and Western blot technique.
  
  
  RESULTS
  The expression of IGF-I R mRNA in poor responders (follicles < or = 3) was much lower than in normal responders (follicles 4-13) and high responders (follicles > or = 14) (1.70 +/- 0.23, 2.92 +/- 0.49, 4.22 +/- 1.50 respectively). Similar results were obtained for IGF-I R (1.32 +/- 0.31, 2.01 +/- 0.72, 4.39 +/- 2.31 respectively).
  
  
  CONCLUSIONS
  The expression of IGF-I R correlated with the effects of gonadotropin hormone on follicular development.
authors.affiliation: Department of Gynecology, Affiliated Obstetrics and Gynecology Hospital, Faculty of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: D
authors.initials: D
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Shi
authors.forename: H
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006080:Ovarian Follicle / Q000254:growth & development*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D013480:Superovulation / Q000502:physiology*
chemical_list: D017526:Receptor, IGF Type 1