6-mercaptopurine: efficacy and bone marrow toxicity in childhood acute lymphoblastic leukemia. Association with low (thio)purine enzyme activity.
De Abreu
R A
RA
Department of Pediatrics, Center for Pediatric Oncology SEN, University Medical Center St Radboud, Nijmegen, The Netherlands.
Lambooy
L H
LH
Ahment
K
K
Brouwer
C
C
Keizer-Garritsen
J J
JJ
Bokkerink
J P
JP
Trijbels
F J
FJ
D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001853:Bone Marrow / Q000187:drug effects*; D002648:Child; D006801:Humans; D015122:Mercaptopurine / Q000009:adverse effects* / Q000627:therapeutic use; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011687:Purines / Q000378:metabolism
D000964:Antimetabolites, Antineoplastic; D011687:Purines; D015122:Mercaptopurine; D008780:Methyltransferases; C022745:thiopurine methyltransferase; C030985:purine