[The experiment of pegylated liposomal doxorubicin to therapy tongue cancer and metastases lymph nodes].
OBJECTIVE
To investigate the effects of pegylated liposmal doxorubicin (PLD) in treating animal model of tongue cancer.


METHODS
The tongue cancer model was established in 70 goldn hamsters, and PLD was injected. The free doxorubicin and its concentration in circulating blood and lymph nodes, the weight of animals, volume of tumor, were defected.


RESULTS
Tumor inhibition effect of the PLD group was higher than controls.


CONCLUSIONS
PLD can be regarded as a valuable drug system to treat oral cancer.
Chen
S
S
Department of Oral Maxillofacial Surgery, College of Stomatology, West China University of Medical Sciences, Chengdu 610041, China.
Pan
J
J
Liao
X
X
D000818:Animals; D000970:Antineoplastic Agents / Q000097:blood / Q000627:therapeutic use*; D006224:Cricetinae; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000097:blood / Q000627:therapeutic use*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D008207:Lymphatic Metastasis; D014062:Tongue Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D004337:Drug Carriers; D008081:Liposomes; D004317:Doxorubicin