[Effect of huanyuan injection on plasma endothelin and plasma calcitonin gene-related peptide in acute intracerebral hemorrhage].
OBJECTIVE
To study the mechanism of Huanyuan injection in treating acute intracerebral hemorrhage.


METHODS
Forty-five patients were divided into Huanyuan group and mannitol group who were treated with Huanyuan injection and mannitol intravenously for two weeks respectively. Meanwhile, the two groups were also treated with vitamin C, potassium chloride, etc, intravenously. Plasma endothelin (ET) and calcitonin gene-related peptide (CGRP) levels were determined before and after treatment.


RESULTS
After treatment for two weeks, changes of plasma ET and CGRP in mannitol group was insignificant (P > 0.05). Compared with the two treated group, There was obvious significance in plasma ET levels and CGRP content (P < 0.05).


CONCLUSIONS
Therapeutic mechanism of Huanyuan injection in treating acute intracerebral hemorrhage were correlated to reduce plasma ET and raise the CGRP levels.
Zhang
C
C
Shanghai Eastern Hospital, Shanghai (200120).
Li
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged
D004365:Drugs, Chinese Herbal; D016232:Endothelins; D015740:Calcitonin Gene-Related Peptide