title: 6-mercaptopurine: efficacy and bone marrow toxicity in childhood acute lymphoblastic leukemia. Association with low (thio)purine enzyme activity.
authors.affiliation: Department of Pediatrics, Center for Pediatric Oncology SEN, University Medical Center St Radboud, Nijmegen, The Netherlands.
authors.forename: R A
authors.initials: RA
authors.lastname: De Abreu
authors.forename: L H
authors.initials: LH
authors.lastname: Lambooy
authors.forename: K
authors.initials: K
authors.lastname: Ahment
authors.forename: C
authors.initials: C
authors.lastname: Brouwer
authors.forename: J J
authors.initials: JJ
authors.lastname: Keizer-Garritsen
authors.forename: J P
authors.initials: JP
authors.lastname: Bokkerink
authors.forename: F J
authors.initials: FJ
authors.lastname: Trijbels
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001853:Bone Marrow / Q000187:drug effects*; D002648:Child; D006801:Humans; D015122:Mercaptopurine / Q000009:adverse effects* / Q000627:therapeutic use; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011687:Purines / Q000378:metabolism
chemical_list: D000964:Antimetabolites, Antineoplastic; D011687:Purines; D015122:Mercaptopurine; D008780:Methyltransferases; C022745:thiopurine methyltransferase; C030985:purine