Serotonin transporter promoter genotype and illness recurrence in mood disorders.
We tested the hypothesis that allelic variation of 5-HTT linked polymorphic region (5-HTTLPR) could influence illness onset and recurrence in 129 bipolar and 128 unipolar recurrent patients. Among bipolar patients, homozygotes for the short variant showed an earlier age at onset and a lower recurrence rate than heterozygotes and homozygotes for the long variant. Unipolar patients showed a trend toward the same difference. Data support a role for 5-HTTLPR in course of affective illness.
Smeraldi
Enrico
E
Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University Vita-Salute, Via Prinetti 29, 20127, Milan, Italy.
Benedetti
Francesco
F
Zanardi
Raffaella
R
D000328:Adult; D000368:Aged; D000483:Alleles; D000704:Analysis of Variance; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D009419:Nerve Tissue Proteins; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012008:Recurrence; D012189:Retrospective Studies; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins