Hyaluronan: polysaccharide chaos to protein organisation.
Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan-protein interactions. Various studies on hyaluronan-binding proteins suggest there is considerable diversity in their mode of interaction with hyaluronan, which might result in many different bound conformations of the polysaccharide.
Day
A J
AJ
Department of Biochemistry, University of Oxford, UK. ajday@bioch.ox.ac.uk
Sheehan
J K
JK
D002236:Carbohydrate Conformation; D018960:Hyaluronan Receptors / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D046911:Macromolecular Substances; D008958:Models, Molecular; D011133:Polysaccharide-Lyases / Q000737:chemistry; D011485:Protein Binding; D012996:Solutions; D013816:Thermodynamics
D018960:Hyaluronan Receptors; D046911:Macromolecular Substances; D012996:Solutions; D006820:Hyaluronic Acid; D011133:Polysaccharide-Lyases; C100002:hyaluronate lyase