title: Diagnosing childhood tumors: A review of 147 cutting needle biopsies in 110 children.
abstract: OBJECTIVE
  The aims of this study were to evaluate the diagnostic accuracy and safety of cutting needle biopsy for diagnosis in children with tumors suspected for malignancy.
  
  
  METHODS
  Medical records and biopsy slides recorded from 1988 to 1999 were reviewed. One hundred ten patients had undergone a total of 147 cutting needle biopsies. The biopsy was performed under ultrasound guidance, using a 1.2-mm (18 gauge) Biopsy-cut biopsy needle. The diagnoses were benign tumors (n = 8), malignant tumors (n = 84), and nonneoplastic diseases (n = 18), with repeat biopsy performed in 24 patients.
  
  
  RESULTS
  The diagnostic accuracy of cutting needle biopsies was 89% (131 of 147). The accuracy for pretreatment diagnosis was 88% (102 of 116), and for confirming or excluding a recurrence or metastasis 93% (26 of 28). The sensitivity of this method was 82% (86 of 105), and the positive predictive value 99% (86 of 87). Nondiagnostic cutting needle biopsy (n = 16) was not related to the age of the patient, experience of the radiologist, number of needle insertions, or site of puncture. No patient exhibited tumor growth along the needle tract. Complications occurred in 10 cases (7%) and pain in 20 (14%).
  
  
  CONCLUSIONS
  Cutting needle biopsy is an accurate and safe procedure with a low learning threshold that is recommended for diagnosing malignancies in childhood.
authors.affiliation: Department of Pediatric Surgery, University Children's Hospital, Uppsala, Sweden.
authors.forename: Erik G
authors.initials: EG
authors.lastname: Sköldenberg
authors.forename: Ake
authors.initials: A
authors.lastname: Jakobson A
authors.forename: Anders
authors.initials: A
authors.lastname: Elvin
authors.forename: Bengt
authors.initials: B
authors.lastname: Sandstedt
authors.forename: Leif
authors.initials: L
authors.lastname: Olsen
authors.forename: Rolf H
authors.initials: RH
authors.lastname: Christofferson
mesh_terms: D000293:Adolescent; D001707:Biopsy, Needle / Q000592:standards*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009369:Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional