Research advances in ethanol metabolism.
The pharmacokinetics of alcohol determines the time course of alcohol concentration in blood after the ingestion of an alcoholic beverage and the degree of exposure of organs to its effects. The interplay between the kinetics of absorption, distribution and elimination is thus important in determining the pharmacodynamic responses to alcohol. There is a large degree of variability in alcohol absorption, distribution and metabolism, as a result of both genetic and environmental factors. The between-individual variation in alcohol metabolic rates is, in part due to allelic variants of the genes encoding the alcohol metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). This review summarizes recent developments in the investigation of the following influences on alcohol elimination rate: gender, body composition and lean body mass, liver volume, food and food composition, ethnicity, and genetic polymorphisms in alcohol metabolizing enzymes as well as in the promoter regions of the genes for these enzymes. Evaluation of the factors regulating the rates of alcohol and acetaldehyde metabolism, both genetic and environmental, will help not only to explain the risk for development of alcoholism, but also the risk for development of alcohol-related organ damage and developmental problems.
Ramchandani
V A
VA
Department of Medicine, Indiana University School of Medicine, 975, W. Walnut Street, IB 424, Indianapolis, IN 46202-5121, USA. vramchan@iupui.edu
Bosron
W F
WF
Li
T K
TK
D000426:Alcohol Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000235:genetics / Q000378:metabolism; D001823:Body Composition; D000431:Ethanol / Q000378:metabolism* / Q000493:pharmacokinetics; D005260:Female; D005502:Food; D006801:Humans; D007700:Kinetics; D008297:Male; D011110:Polymorphism, Genetic; D044469:Racial Groups; D012727:Sex Characteristics
D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase