title: The KIR and CD94/NKG2 families of molecules in the rhesus monkey.
abstract: Natural killer (NK) cells and a subset of T cells express families of receptors that are capable of detecting major histocompatibility complex (MHC) class I expression on the surface of cells. Molecules of the killer cell immunoglobulin-like receptor (KIR) family bind directly to MHC class I, while those of the CD94/NKG2 family recognize MHC class I signal sequences bound to HLA-E. Both the KIR and CD94/NKG2 families are composed of activating and inhibitory molecules that serve to regulate the function of NK cells as a result of their MHC class I recognition. Here we review the recently described KIR and CD94/NKG2 family members in the rhesus monkey.
authors.affiliation: Harvard Medical School, Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: LaBonte
authors.forename: K L
authors.initials: KL
authors.lastname: Hershberger
authors.forename: B
authors.initials: B
authors.lastname: Korber
authors.forename: N L
authors.initials: NL
authors.lastname: Letvin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000737:chemistry* / Q000502:physiology; D017124:Conserved Sequence; D006801:Humans; D037181:Lectins, C-Type; D008253:Macaca mulatta / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D010802:Phylogeny; D011971:Receptors, Immunologic / Q000737:chemistry* / Q000502:physiology; D054340:Receptors, KIR; D055607:Receptors, Natural Killer Cell; D016415:Sequence Alignment
chemical_list: D015703:Antigens, CD; C527054:KLRC1 protein, human; C497869:KLRD1 protein, human; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D055607:Receptors, Natural Killer Cell