Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins.
Boutaud
O
O
Department of Medicine, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA.
Li
J
J
Chaurand
P
P
Brame
C J
CJ
Marnett
L J
LJ
Roberts
L J
LJ
Oates
J A
JA
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D010100:Oxygen; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D007527:Isoenzymes; D011458:Prostaglandins E; D011506:Proteins; D017382:Reactive Oxygen Species; D016718:Arachidonic Acid; C047684:levuglandin E2; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D010100:Oxygen