title: Novel cyclic sugar imines: carbohydrate mimics and easily elaborated scaffolds for aza-sugars.
abstract: [reaction: see text] Representative simple or polyhydroxylated, pyrrolidine (e.g, DRAM) or piperidine (e.g., DNJ) imines not only are potential carbohydrate-processing enzyme inhibitors that may be formed as regioisomeric variants but also are scaffolds that may be rapidly elaborated to diversely functionalized aza-sugars through highly diastereoselective organometallic additions.
authors.affiliation: Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QY, UK. ben.davis@chem.ox.ac.uk
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Davis
authors.forename: Michael A T
authors.initials: MA
authors.lastname: Maughan
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Chapman
authors.forename: Renaud
authors.initials: R
authors.lastname: Villard
authors.forename: Steve
authors.initials: S
authors.lastname: Courtney
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis*; D002241:Carbohydrates / Q000138:chemical synthesis*; D003500:Cyclization; D007097:Imines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry
chemical_list: D001372:Aza Compounds; D002241:Carbohydrates; D007097:Imines