Ethanol and N-acetylcysteine influence on the development of liver changes in experimental methanol intoxication.
The evaluation of ethanol and N-Acetylcysteine (NAC) influence on histopathological changes in rat liver intoxicated with 3 g of methanol/kg b.w. was conducted, based on morphological examinations in light and electron microscope. The rats received intragastrically 3.0 g of methanol/kg b.w. as a 50% solution, 10% ethanol for 24 hours before methanol and next 48 hours after methanol ingestion and NAC (150 mg/kg b.w.) after 15 min. methanol administrated. The results indicate that methanol intoxication causes pronounced morphological changes in the examined organ. Ethanol administered to methanol-intoxicated rats caused intensification of certain parameters of hepatocytes morphological damage. A simultaneous administration of methanol and NAC resulted in a lower degree of parenchymal damage.
Kasacka
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I
Departments of Histology & Embriology, Medical Academy of Białystok, Białystok, Poland.
Skrzydlewska
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E
D000111:Acetylcysteine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D000432:Methanol / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar
D000431:Ethanol; D000111:Acetylcysteine; D000432:Methanol