title: [Apoptosis inducing effect of meisoindigo on K562 cells].
abstract: OBJECTIVE
  To study the effect of meisoindigo on human chronic myelogenous leukemia (CML) cell line K562 cells for exploring the mechanism of meisoindigo in treatment of CML.
  
  
  METHODS
  Multiple methods, including dose-response curve, trypan blue exclusion, cytomorphology, DNA electrophoresis, flow cytometry and TUNEL (TdT mediated dUTP nick and labeling), were used to observe the effect of meisoindigo on K562 cells.
  
  
  RESULTS
  Meisoindigo can inhibit the proliferation and induce the apoptosis of K562 cells.
  
  
  CONCLUSIONS
  The therapeutic mechanism of meisoindigo in treating CML may be related with its proliferation inhibiting and apoptosis inducing effect in CML cells.
authors.affiliation: Institute of Hematology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin (300020).
authors.forename: L
authors.initials: L
authors.lastname: Song
authors.forename: L
authors.initials: L
authors.lastname: Qian
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D020014:K562 Cells / Q000473:pathology*
chemical_list: D007211:Indoles; C047330:N-methylisoindigotin