title: Apoptosis induced by picolinic acid-related compounds in HL-60 cells.
abstract: We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various picolinic acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells. These results suggest that pyridine substituted with various groups and the consequent change of resonance structure may have an important role in the induction of apoptosis.
authors.affiliation: Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ogata
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Iwata
authors.forename: K
authors.initials: K
authors.lastname: Okumura
authors.forename: H
authors.initials: H
authors.lastname: Taguchi
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D053938:DNA Fragmentation; D005434:Flow Cytometry; D005669:Fusaric Acid / Q000494:pharmacology; D018922:HL-60 Cells / Q000187:drug effects*; D006801:Humans; D010848:Picolinic Acids / Q000494:pharmacology*
chemical_list: D010848:Picolinic Acids; D005669:Fusaric Acid