title: Designing membrane electrochemical reactors for oxidoreductase-catalysed synthesis.
abstract: The purpose of this work was to design an electrochemical reactor to enhance the high selectivity of enzyme-catalysed processes. In order to develop economically efficient syntheses, the enzymes must be confined in the strict vicinity of the electrode surface. Here the confinement was achieved with a dialysis membrane in a so-called Dialysis-Membrane Electrochemical Reactor (D-MER). Oxidation of glucose into gluconic acid catalysed by glucose oxidase was a first example. The ADH-catalysed reduction of cyclohexanone into cyclohexanol was also tested in a new type of MER. NADH was electrochemically regenerated thanks to mediator (methyl viologen or rhodium complex). The key point in developing electro-enzymatic process is to ensure the perfect fitting of the reactor design to the reactions that are to be processed.
authors.affiliation: Laboratoire de Génie Chimique-CNRS, Université Paul Sabatier, 118 route de Narbonne, F-31062 Toulouse, France.
authors.forename: K
authors.initials: K
authors.lastname: Délécouls-Servat
authors.forename: R
authors.initials: R
authors.lastname: Basséguy
authors.forename: A
authors.initials: A
authors.lastname: Bergel
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D002384:Catalysis; D004563:Electrochemistry / Q000295:instrumentation*; D004867:Equipment Design; D005942:Gluconates / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005949:Glucose Oxidase / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D005942:Gluconates; D000426:Alcohol Dehydrogenase; D005949:Glucose Oxidase; D005947:Glucose; C030691:gluconic acid