Temporal fluctuations of myocardia high-energy phosphate metabolite with the cardiac cycle.
This review describes the temporal changes of high-energy phosphate metabolites during the cardiac cycle. Under baseline condition, the extent of cyclical changes ("cycling") of ATP, phosphocreatine and inorganic phosphate varies between 10-15%. Such energy oscillations are not augmented under various forms of metabolic stress including 1) inotropic stimulation, 2) acute hypoxia and 3) failing, chronically infarcted hearts. Thus, the concentrations of high-energy phosphates over the cardiac cycle are a tightly regulated entity, even when energetic needs are substantially augmented.
Spindler
M
M
Medizinische Universitätsklinik Würzburg, Germany. spindler@mail.uni-wuerzburg.de
Illing
B
B
Horn
M
M
de Groot
M
M
Ertl
G
G
Neubauer
S
S
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*
D000255:Adenosine Triphosphate