Pharmacogenetic tactics and strategies: implications for paediatrics.
Genetic diversity exerts profound effects on variation in human drug response in adults, but comparatively little research that specifically relates to genetically abnormal responses in infancy and childhood has been reported. Specific genetic changes in human enzymes, receptors and other proteins that are implicated in drug response and their associated phenotypic correlates provide needed data for construction of profiles individualised to predict susceptibility to adverse drug reactions. If therapy adheres to such guidelines, failure to respond to drug therapy and drug toxicity among genetically susceptible persons can be greatly minimised or averted.
Weber
W W
WW
Department of Pharmacology, University of Michigan, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0632, USA. wwweber@umich.edu
D005544:Forecasting; D006801:Humans; D010372:Pediatrics / Q000639:trends*; D010597:Pharmacogenetics / Q000639:trends*