Modification of humoral immune response in C57Bl/6 mice with a complex of alpha-fetoprotein and retinoid acid derivatives.
Amides of all trans-retinoic acid and O-phospho-L-threonine, O-phospho-L-tyrosine, and O-phosphoethanolamine injected intravenously in a dose of 6.8 microg/kg 1.5-3.4-fold increased the count of antibody-producing cells in the spleen of C57Bl/6 mice (primary immune response to sheep erythrocytes). Activity of the complex containing alpha-fetoprotein and L-threonine ligand did not differ from that of free retinoid. This complex holds much promise as a prototype of immunomodulators with a wide range of activity.
Arsenov
D V
DV
Department of Biological Assays, Institute of Bioorganic Chemistry, National Belarussian Academy of Sciences, Minsk.
Golubeva
M B
MB
Kisel'
M A
MA
Konoplya
N A
NA
Lyubin
G S
GS
Kuz'mitskii
B B
BB
Strel'chenok
O A
OA
D000818:Animals; D007109:Immunity / Q000187:drug effects*; D008024:Ligands; D051379:Mice; D008810:Mice, Inbred C57BL; D008956:Models, Chemical; D013912:Threonine / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism / Q000494:pharmacology*; D000509:alpha-Fetoproteins / Q000494:pharmacology*
D008024:Ligands; D000509:alpha-Fetoproteins; D013912:Threonine; D014212:Tretinoin