Solid phase synthesis of mixture-based acyclic and heterocyclic small molecule combinatorial libraries from resin-bound polyamides.
The development of soluble mixture-based heterocyclic combinatorial libraries derived from amino acids and peptides is described. Starting with a "toolbox" of various chemical transformations, including alkylations, reductions, acylations, and the use of a variety of bifunctional reagents, the "libraries from libraries" concept has been expanded to encompass the development of more than fifty positional scanning combinatorial libraries each composed of tens of thousands of low molecular weight acyclic and heterocyclic compounds.
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Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, Building 2, Room 138, San Diego, CA 92121, USA.
Ostresh
J M
JM
Houghten
R A
RA
D020650:Combinatorial Chemistry Techniques; D019791:Guanidine / Q000737:chemistry; D008239:Lysine / Q000737:chemistry; D008956:Models, Chemical; D010452:Peptide Biosynthesis; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D013890:Thiourea / Q000737:chemistry
D019151:Peptide Library; D010455:Peptides; D013890:Thiourea; D019791:Guanidine; D008239:Lysine