[The polymorphism of (CAG)n repeats within androgen receptor gene among Chinese male population].
OBJECTIVE
To investigate the polymorphism of (CAG)n repeats within androgen receptor (AR) gene among normal Chinese male population.


METHODS
dsDNA cycle sequencing and[alpha-(32)PdCTP] incorporated asymmol/Letric PCR-denaturing polyacrylamide gel electrophoresis(PAGE) were used to determine the number of (CAG)n repeats in normal men (n=107).


RESULTS
The number of polymorphic (CAG)n repeats ranges from 11 to 29; the most frequent repeat is 22(20/107); the less frequent repeats are 23(15/107), 24(11/107), 21(11/107) and 20(8/107).


CONCLUSIONS
The AR gene (CAG)n exhibits polymorphism among normal male population and the present work could serve as a basis for further exploration of its pathological and genetic significance.
Wang
G
G
Department of Pathophysiology, the Second Military Medical University, Shanghai, 200433 P. R. China. Lujian@smmu.edu.cn
Chen
G
G
Wang
X
X
Zhong
J
J
Lu
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002681:China; D004247:DNA / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D017422:Sequence Analysis, DNA; D018911:Trinucleotide Repeats / Q000235:genetics*
D011944:Receptors, Androgen; D004247:DNA