title: Understanding cytotoxic T-lymphocyte escape during simian immunodeficiency virus infection.
abstract: Infection of rhesus macaques with simian immunodeficiency virus (SIV) is an excellent model system for studying viral adaptation to immune responses. In this review, we discuss how the SIV-infected macaque has provided unequivocal evidence for cytotoxic T-lymphocyte (CTL) selection of viral escape variants. This improved understanding of CTL escape may influence human immunodeficiency virus (HIV) vaccine design as well as our understanding of HIV pathogenesis.
authors.forename: D
authors.initials: D
authors.lastname: O'Connor
authors.forename: T
authors.initials: T
authors.lastname: Friedrich
authors.forename: A
authors.initials: A
authors.lastname: Hughes
authors.forename: T M
authors.initials: TM
authors.lastname: Allen
authors.forename: D
authors.initials: D
authors.lastname: Watkins
mesh_terms: D016915:AIDS Vaccines; D000818:Animals; D000940:Antigenic Variation / Q000235:genetics / Q000276:immunology; D000956:Antigens, Viral; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D000956:Antigens, Viral; D018984:Epitopes, T-Lymphocyte