Platelet regulation of thrombin generation in cardiovascular disease.
Platelets are intimately involved in the events leading to cardiac ischemia through their release of bioactive substances, aggregation, and support of procoagulant reactions at sites of atherosclerotic plaque formation and rupture. This review article will focus on what is currently known about the regulation of thrombin generation on the surface of activated platelets, and how it relates to thrombus formation.
Bouchard
B A
BA
Department of Biochemistry, University of Vermont, College of Medicine, Burlington 05405-0068, USA.
Tracy
P B
PB
D001161:Arteriosclerosis / Q000503:physiopathology*; D001792:Blood Platelets / Q000502:physiology*; D005165:Factor V / Q000502:physiology*; D006801:Humans; D017202:Myocardial Ischemia / Q000209:etiology* / Q000503:physiopathology; D013917:Thrombin / Q000502:physiology*
D005165:Factor V; D013917:Thrombin