title: Cadherin expression in the eye.
abstract: E(pithelial)-cadherin and N(eural)-cadherin are transmembrane cell-cell adhesion molecules, belonging to the subfamily of classical cadherins. The expression of E- and N-cadherin is spatiotemporally regulated and associated with a variety of normal morphogenetic events. The expression of E- and N- cadherin is also involved in carcinogenesis. E-cadherin functions as a tumor-suppressor. N-cadherin, however, is associated with cancer progression. The study of the expression pattern of E- and N-cadherin in the normal and tumorous eye is the aim of our research.
authors.affiliation: Dpt. Of Ophthalmology, Ghent University Hospital, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Van Aken
authors.forename: P
authors.initials: P
authors.lastname: Papeleu
authors.forename: P
authors.initials: P
authors.lastname: De Potter
authors.forename: J J
authors.initials: JJ
authors.lastname: De Laey
authors.forename: M
authors.initials: M
authors.lastname: Mareel
mesh_terms: D000818:Animals; D015820:Cadherins / Q000032:analysis*; D003315:Cornea / Q000378:metabolism; D015536:Down-Regulation; D005123:Eye / Q000378:metabolism*; D005128:Eye Diseases / Q000378:metabolism*; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism; D010857:Pigment Epithelium of Eye / Q000737:chemistry; D012016:Reference Values; D019572:Retinal Neoplasms / Q000378:metabolism; D012175:Retinoblastoma / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D015820:Cadherins