title: Continuous therapeutic ultrasound accelerates repair of contraction-induced skeletal muscle damage in rats.
abstract: OBJECTIVE
  To examine the effect of ultrasonography on the repair of muscle injured through repeated eccentric contractions.
  
  
  METHODS
  Randomized, case-control study.
  
  
  METHODS
  Laboratory animal facility.
  
  
  METHODS
  Thirty-three Sprague-Dawley rats.
  
  
  METHODS
  Specimens were anesthetized and each foot strapped, in turn, onto a motorized foot pedal, which moved the ankle repeatedly through a range of 110 degrees. Extensor digitorum longus muscles were injured by stimulating the peroneal nerve during foot plantarflexion. Continuous 1.0MHz ultrasound treatments at 0.5W/cm(2) were applied through water submersion technique to 1 limb daily for 3, 5, or 7 days postinjury. The contralateral limb served as an injured control.
  
  
  METHODS
  Extensor digitorum longus maximum isometric tetanic force (P(o)) was measured in vitro from all extensor digitorum longus muscles and used as a functional index of muscle injury.
  
  
  RESULTS
  Analysis of variance and Tukey post hoc analysis showed no significant differences in P(o) between treated and untreated limbs at 3 and 5 days, but at 7 days postinjury, P(o) of ultrasound-treated muscle was significantly higher than was untreated muscle.
  
  
  CONCLUSIONS
  Seven days of continuous therapeutic ultrasound improved force production after contraction-induced muscle injury.
authors.affiliation: Department of Physical Therapy, D'Youville College, Buffalo, NY 14201-1084, USA. karnesj@dyc.edu
authors.forename: James L
authors.initials: JL
authors.lastname: Karnes
authors.forename: Harold W
authors.initials: HW
authors.lastname: Burton
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016022:Case-Control Studies; D004558:Electric Stimulation; D018409:Foot Injuries / Q000628:therapy*; D008297:Male; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000293:injuries*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014464:Ultrasonic Therapy; D014945:Wound Healing / Q000502:physiology*