Rheumatological complications associated with the use of indinavir and other protease inhibitors.
Several cases are reported of rheumatological pathology (temporomandibular dysfunction, frozen shoulder, Dupuytren's disease, and tendinitis) most probably related to the intake of indinavir in HIV positive patients. A survey using an anonymous questionnaire of 878 people with HIV infection treated with antiretroviral drugs suggests that other protease inhibitors may also cause arthralgia.
Florence
E
E
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Schrooten
W
W
Verdonck
K
K
Dreezen
C
C
Colebunders
R
R
D000328:Adult; D004387:Dupuytren Contracture / Q000139:chemically induced; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000139:chemically induced*; D019534:Shoulder Impingement Syndrome / Q000139:chemically induced; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000139:chemically induced; D052256:Tendinopathy / Q000139:chemically induced
D017320:HIV Protease Inhibitors; D019469:Indinavir