[Clinical study on tangshen mixture in treating diabetic nephropathy].
OBJECTIVE
To investigate the effects of Tangshen Mixture (TSM) on the serum glucose, quantity of proteinuria per 24 h, hypercoagulative status and oxidative injury in patients with diabetic nephropathy (DN).


METHODS
Ninety-three patients with DN were randomly divided into treated group and control group. 48 patients in the former were treated with insulin and TSM, while the latter was treated with insulin alone. Before and after treatment, the levels of fasting blood glucose (FBG), 2 h after meal blood glucose (PBG), 24 h urinary albumin (24 h-pro), endothelin (ET), alpha-granule membrane glycoprotein-140 (GMP-140), erythrocyte superoxide dismutase (ESOD), lipid peroxidase (LPO) were measured.


RESULTS
After two months treatment, compared with the control group the levels of ET and GMP-140, LPO, and 24 h-pro lowered obviously (P < 0.01, P < 0.05), and the level of ESOD increased (P < 0.05) in the treated group, no obvious change was found in control grout after treatment.


CONCLUSIONS
TSM could improve the hypercoagulative status, alleviate the renal free radical disturbances, and reduce the urinary protein loss.
Yu
Z
Z
Fuzhou General Hospital of Nanjing Military Region, Fuzhou (350025).
Zhuang
Y
Y
Dai
X
X
D000328:Adult; D000368:Aged; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000188:drug therapy
D004365:Drugs, Chinese Herbal; D007328:Insulin