title: Bacteriopurpurinimides: highly stable and potent photosensitizers for photodynamic therapy.
abstract: The in situ conversion of the unstable bacteriochlorophyll a present in Rhodobacter sphaeroides produced highly stable bacteriopurpurin-18 which in a sequence of reactions was converted into a series of alkyl ether analogues of bacteriopurpurin-18-N-alkylimides with long wavelength absorption near 800 nm. The effective photosensitizers were found to localize in mitochondria but did not show any specific displacement of (3)H-PK11195, suggesting that the mitochondrial peripheral benzodiazepine receptor is not the cellular binding site for this class of compounds.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Chen
authors.forename: Andrew
authors.initials: A
authors.lastname: Graham
authors.forename: William
authors.initials: W
authors.lastname: Potter
authors.forename: Janet
authors.initials: J
authors.lastname: Morgan
authors.forename: Lurine
authors.initials: L
authors.lastname: Vaughan
authors.forename: David A
authors.initials: DA
authors.lastname: Bellnier
authors.forename: Barbara W
authors.initials: BW
authors.lastname: Henderson
authors.forename: Allan
authors.initials: A
authors.lastname: Oseroff
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Dougherty
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Pandey
mesh_terms: D000818:Animals; D025541:Bacteriochlorophyll A / Q000737:chemistry; D001667:Binding, Competitive; D002460:Cell Line; D005453:Fluorescence; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D012242:Rhodobacter sphaeroides / Q000737:chemistry; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013053:Spectrophotometry / Q000379:methods
chemical_list: D025541:Bacteriochlorophyll A; D017319:Photosensitizing Agents; D011166:Porphyrins