title: Biomaterial patches sutured onto the rat stomach induce a set of genes encoding pancreatic enzymes.
abstract: Asymmetric patches of polyhydroxybutyric acid with one smooth and one rough surface were produced by a dipping procedure. These patches were implanted into the rat gastrointestine and tissue samples were generated at distinct time intervals after surgery. The host's response towards the foreign material was analyzed by Differential Display and RNA profiles were compared to each other. One to two weeks after surgery a group of mRNAs encoding pancreatic enzymes was transiently present after biomaterial implantation.
authors.affiliation: Klinik und Poliklinik für Chirurgie der Universität Rostock, Forschugslabor, Germany. loebler@ch11.ukl.uni-freiburg.de
authors.forename: Marian
authors.initials: M
authors.lastname: Löbler
authors.forename: Marko
authors.initials: M
authors.lastname: Sass
authors.forename: Carmen
authors.initials: C
authors.lastname: Kunze
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Schmitz
authors.forename: Ulrich T
authors.initials: UT
authors.lastname: Hopt
mesh_terms: D000818:Animals; D001483:Base Sequence; D001672:Biocompatible Materials; D017931:DNA Primers; D005753:Gastric Mucosa / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D008297:Male; D008855:Microscopy, Electron, Scanning; D010179:Pancreas / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D001672:Biocompatible Materials; D017931:DNA Primers