Spontaneous bacterial peritonitis caused by quinolone-resistant Escherichia coli: could steroid therapy play a role?
Prophylaxis with norfloxacin has been shown to be effective in preventing spontaneous bacterial peritonitis (SBP) in liver cirrhosis. This therapy is associated with the appearance of quinolone-resistant Escherichia coli. However, only four cases of SBP caused by quinolone-resistant E. coli have been reported so far. We present four cases of quinolone-resistant E. coli SBP in three patients receiving oral quinolones, and who were on corticosteroid therapy to treat associated disorders.
Cereto
Ferran
F
Liver Unit, Department of Internal Medicine, Hospital General Universitari Vall d'Hebron, Barcelona, Spain. cereto@hg.vhebron.es
Genescà
Joan
J
Smithson
Alex
A
González
Antonio
A
Moreno
Gina
G
del Valle Ortiz
Oscar
O
Esteban
Rafael
R
Guardia
Jaime
J
D000368:Aged; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000175:diagnosis* / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000494:pharmacology / Q000627:therapeutic use; D010538:Peritonitis / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control*; D011241:Prednisone / Q000627:therapeutic use
D000890:Anti-Infective Agents; D005938:Glucocorticoids; D009643:Norfloxacin; D011241:Prednisone