[Liquid phase cytology in the primary screening for cervical cancer: a multicenter study].
The aim of this six-centre, split-sample study was to compare ThinPrep fluid-based cytology to the conventional Papanicolaou smear. Six Cytopathology laboratories and 35 Gynaecologists participated. 5428 patients met the inclusion criteria. Each cervical sample was used first to prepare a conventional Pap smear, then the sampling device was rinsed into a PreservCyt vial, and a ThinPrep slide was made. Screening of slide pairs was blinded. On initial screening, 29% more ASCUS and 39% more low-grade squamous intraepithelial lesions (LSIL) and more severe lesions (LSIL+) were detected on the ThinPrep slides than on the conventional smears (p = 0.001). Independent and consensus review confirmed 145 LSIL + diagnoses; of these, 18% more had been detected initially on the ThinPrep slides than on the conventional smears (p = 0.041). The ThinPrep Pap Test is more accurate than the conventional Pap Test and has the potential to optimize the effectiveness of primary cervical cancer screening.
Monsonégo
J
J
Institut Alfred Fournier, 25, boulevard Saint-Jacques, 75014 Paris, France. admin@eurogin.com
Autillo-Touati
A
A
Bergeron
C
C
Dachez
R
R
Liaras
J
J
Saurel
J
J
Zerat
L
L
Chatelain
P
P
Mottot
C
C
D000328:Adult; D003581:Cytodiagnosis / Q000379:methods*; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D012680:Sensitivity and Specificity; D012996:Solutions; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears / Q000379:methods*; D002578:Uterine Cervical Dysplasia / Q000473:pathology
D012996:Solutions
Cytologie en phase liquide dans le cadre du dépistage primaire du cancer du col utérin: une étude multicentrique.