[Myelotoxicity of a plant cytostatic preparation etoposide].
The myelotoxicity and the hemopoiesis recovery effect of etoposide, an antitumor preparation of the podophyllotoxin group, were experimentally studied on mice. It was found that the main role in the hemopoiesis recovery after etoposide administration is related to accelerated proliferation and increased differentiation of the hemopoietic precursor cells.
Dygaĭ
A M
AM
Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Udut
E V
EV
Zhdanov
V V
VV
Tkachenko
S B
SB
Guriantseva
L A
LA
Simanina
E V
EV
Boldyshev
D A
DA
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D001772:Blood Cell Count; D001854:Bone Marrow Cells / Q000187:drug effects*; D003114:Colony-Forming Units Assay; D005047:Etoposide / Q000633:toxicity*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide
Mielotoksichnost' tsitostaticheskogo preparata rastitel'nogo proiskhozhdeniia--étoposida.