title: [Trans-effect of modifiers on position-effect variegation in a set of euchromatin-heterochromatin rearrangements in Drosophila melanogaster].
abstract: The effects of suppressors of position-effect variegation were studied in a set of euchromatin-heterochromatin rearrangements of the X chromosome accompanied by inactivation of the gene wapl. The rearrangements differed from one another in the size of the heterochromatic block adjacent to euchromatin, with the euchromatin-heterochromatin border remaining unchanged. In one rearrangement (r20), the position effect caused by a small block of adjacent heterochromatin may be determined by its interaction with the neighboring main heterochromatic region of the X chromosome. Chromosome 3 (the RT chromosome) was found to have a strong suppressing effect on all rearrangements, irrespective of the amount of heterochromatin adjacent to euchromatin. Su-var(3)9, a known suppressor of the position-effect variegation, had a considerably weaker suppressing effect. The RT chromosome had the strongest suppressing effect on the rearrangement r20.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russia. popkova@img.ras.ru
authors.forename: A M
authors.initials: AM
authors.lastname: Popkova
authors.forename: V I
authors.initials: VI
authors.lastname: Rasheva
authors.forename: E V
authors.initials: EV
authors.lastname: Tolchkov
authors.forename: V E
authors.initials: VE
authors.lastname: Alatortsev
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D022041:Euchromatin / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D006570:Heterochromatin / Q000235:genetics*; D017403:In Situ Hybridization; D008297:Male; D014960:X Chromosome
chemical_list: D022041:Euchromatin; D006570:Heterochromatin
vernacular_title: Issledovanie trans-deĭstviia modifikatorov na éffekt polozheniia v serii éu-geterokhromaticheskikh perestroek Drosophila melanogaster.