[Adrenal ACE and type II glucocorticoid receptors in primary hyperaldosteronism].
Adrenal tissue from 6 patients with primary hyperaldosteronism has been examined for the presence of angiotensin-converting enzyme (ACE). Its activity and amount of glucocorticoid receptors of type II (GR-II) were measured. ACE and GR-II were detected in adrenal tissue. GR-II induce ACE activity in interaction with plasma hydrocortisone. The glucocorticoid-receptor mechanism is an essential element in regulation of ACE activity determining a vasopressor effect. Disclosed is one of the aspects of tissue renin-angiotensin system function in primary hyperaldosteronism.
Trofimova
I B
IB
Golikov
P P
PP
Bogatyrev
O P
OP
Poliakova
G A
GA
Nikolaeva
N Iu
NIu
D000302:Adrenal Cortex / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
D011965:Receptors, Glucocorticoid; D007703:Peptidyl-Dipeptidase A
Nadpochechnikovyĭ angiotenzinprevrashchaiushchiĭ ferment i gliukokortikoidnye retseptory II tipa pri pervichnom giperal'dosteronizme.