[Hypercoagulation aggravates renal dysfunction in patient with diabetic nephropathy].
OBJECTIVE
To investigate the relationship of hypercoagulation and renal dysfunction in patients with diabetic nephropathy(DN).


METHODS
Forty six diabetes type II patients with nephrotic syndrome were divided into 3 groups according to 24 hr creatinine clearance (Ccr) as high, middle and low groups. Fourteen of the 46 patients received warfarin therapy. The parameters of coagulation and fibrolysis as well as renal function were examined.


RESULTS
Patients with moderate and major renal dysfunction (M group and L group) displayed higher activities of coagulation than those with mild renal dysfunction (H group) did. Warfarin could obviously improve the status of coagulation and fibrolysis in patients with DN and delay the progress of renal dysfunction.


CONCLUSIONS
Hypercoa-gulation was one of the causes of renal dysfunction in patients with DN.
Sun
X
X
Department of Nephrology, First Affilliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China.
Zhou
X
X
Yan
H
H
D003404:Creatinine / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000145:classification / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D051437:Renal Insufficiency / Q000209:etiology*; D019851:Thrombophilia / Q000150:complications* / Q000188:drug therapy*; D014859:Warfarin / Q000627:therapeutic use*
D014859:Warfarin; D003404:Creatinine