title: [Transfusion transmitted virus infection in mother-to-infant transmission].
abstract: OBJECTIVE
  To investigate the perinatal infection of transfusion transmitted virus (TTV) in the mother-to-infant transmission and molecular evidence.
  
  
  METHODS
  TTV was examined in serum from 104 mothers and umbilical blood of their infants by a semi-nested polymerase chain reaction technique. TTV nucleotide sequences isolated from two sets of mother/infant pairs were analyzed.
  
  
  RESULTS
  The TTV detection rate was 13.46% (15/104), and it was 4.81% (5/104) in the umbilical blood of their newborns. Homology analysis was done by sequencing between positions 1,915 and 2,185 of the published TTV genome, Analysis of TTV sequences from the 2 pairs of mother and infant both infected confirmed a genetic link between the virus of the infected mother and their infected infants.
  
  
  CONCLUSIONS
  There is a possibility of vertical maternal-fetal transmission of TTV.
authors.affiliation: Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhong
authors.forename: S
authors.initials: S
authors.lastname: Wen
authors.forename: F
authors.initials: F
authors.lastname: Zhou
mesh_terms: D000328:Adult; D004266:DNA Virus Infections / Q000635:transmission*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D022783:Torque teno virus; D065227:Transfusion Reaction