Thrombocytopenia and emperipolesis in a patient with hepatitis a infection.
lmmune thrombocytopenia is a benign, self-limiting disease in children, responding well to treatment and generally associated with viral infections. A 13-year-old girl was admitted to a hospital with the epistaxis and purpura after an attack of jaundice 6 weeks before. The diagnosis of hepatitis A virus (HAV)-induced thrombocytopenia was made. Furthermore, erythrophagocytosis by megakaryocytes was demonstrated in the bone marrow of the patient. Although hematologic complications following hepatitis B and C viruses are commonly reported, the association of hepatitis A virus and thrombocytopenia has rarely been described.
Avci
Zekai
Z
Hacettepe University School of Medicine, Department of Pediatrics, Ankara, Turkey. zavcias@yahoo.com
Turul
Tuba
T
Catal
Ferhat
F
Olgar
Seref
S
Baykan
Ali
A
Tekfam
Ozlem
O
Gürgey
A
A
D000293:Adolescent; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006506:Hepatitis A / Q000150:complications*; D006801:Humans; D008533:Megakaryocytes / Q000473:pathology*; D009196:Myeloproliferative Disorders / Q000209:etiology* / Q000473:pathology; D010587:Phagocytosis; D013921:Thrombocytopenia / Q000209:etiology*