[Zinc and its role in the regulation of cell death].
Zinc is a key element for maintenance of the structural and functional integrity of eukaryotic cells and tissues. In living systems, it forms stable complexes with macromolecules as well as so called labile pools called zincosomes, which are nowadays considered crucial for the regulation of apoptosis and cell proliferation. Zinc may block apoptosis induced by many external factors by inhibiting caspases and endonucleases, through interactions with transcription factors and kinases or due to its antioxidant activities. On the other hand, depletion of zinc may lead to rapid activation of apoptotic cascade and consequent cell death in many types of cells. Imbalances in intracellular zinc pools lead to improper regulation of cell death and proliferation, which is often causing or accompanying diseases. Therefore, detailed elucidation of the role of zinc in these regulations presents a solution for various pathophysiological conditions.
Rudolf
E
E
Ustav lékarské biologie a genetiky, UK, Praha, Lékarská fakulta, Hradec Králové. rudolf@lfhk.cuni.cz
Peychl
J
J
Radocha
J
J
Cervinka
M
M
D017209:Apoptosis / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D006801:Humans; D015032:Zinc / Q000494:pharmacology / Q000502:physiology*
D015032:Zinc
Zinek a jeho role pri regulaci bunĕcné smrti.