Structure and mechanism of chalcone synthase-like polyketide synthases.
Polyketide synthases (PKS) produce an array of natural products with different biological activities and pharmacological properties by varying the starter and extender molecules that form the final polyketide. Recent studies of the simplest PKS, the chalcone synthase (CHS)-like enzymes involved in the biosynthesis of flavonoids, anthocyanin pigments, and antimicrobial phytoalexins, have yielded insight on the molecular basis of this biosynthetic versatility. Understanding the structure-function relationship in these PKS provides a foundation for manipulating polyketide formation and suggests strategies for further increasing the scope of polyketide biosynthetic diversity.
Jez
J M
JM
Structural Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-0634, USA.
Ferrer
J L
JL
Bowman
M E
ME
Austin
M B
MB
Schröder
J
J
Dixon
R A
RA
Noel
J P
JP
D000217:Acyltransferases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D002599:Chalcone / Q000378:metabolism; D000455:Medicago sativa / Q000737:chemistry / Q000201:enzymology* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D012231:Rhizobium / Q000737:chemistry / Q000201:enzymology* / Q000235:genetics; D013329:Structure-Activity Relationship
D009097:Multienzyme Complexes; D002599:Chalcone; D000217:Acyltransferases; C020141:flavanone synthetase