title: DNA and cell cycle analysis as prognostic indicators in breast tumors revisited.
abstract: Both DNA ploidy and S-phase ploidy are promising prognostic factors for node-negative breast cancer patients. Based largely on the analysis of one large study, much of the reported problems with these factors have been caused by some unappreciated complexities in categorizing DNA ploidy into low- and high-risk groups and the lack of some necessary adjustments to eliminate unwanted correlations between DNA S-phase and ploidy. When both DNA ploidy and S-phase are compensated properly, they become independent prognostic markers, forming a powerful prognostic model.
authors.affiliation: Verity Software House, Inc., Topsham, Maine, USA. cbb@vsh.com
authors.forename: C B
authors.initials: CB
authors.lastname: Bagwell
authors.forename: G M
authors.initials: GM
authors.lastname: Clark
authors.forename: F
authors.initials: F
authors.lastname: Spyratos
authors.forename: A
authors.initials: A
authors.lastname: Chassevent
authors.forename: P O
authors.initials: PO
authors.lastname: Bendahl
authors.forename: O
authors.initials: O
authors.lastname: Stål
authors.forename: D
authors.initials: D
authors.lastname: Killander
authors.forename: M L
authors.initials: ML
authors.lastname: Jourdan
authors.forename: S
authors.initials: S
authors.lastname: Romain
authors.forename: B
authors.initials: B
authors.lastname: Hunsberger
authors.forename: S
authors.initials: S
authors.lastname: Wright
authors.forename: B
authors.initials: B
authors.lastname: Baldetorp
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D002453:Cell Cycle / Q000502:physiology*; D004273:DNA, Neoplasm / Q000032:analysis*; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry / Q000379:methods*; D005602:France / Q000453:epidemiology; D006801:Humans; D011003:Ploidies; D011379:Prognosis; D013548:Sweden / Q000453:epidemiology
chemical_list: D004273:DNA, Neoplasm