[Interleukin-1beta and depressive states].
Administration of Interleukin-1 beta (IL-1 beta) in pyrogenic and subpyrogenic doses induced a depression of social and exploratory behaviour in rats. A reduction in locomotor activity only occurred with pyrogenic doses of the IL-1 beta. The low dose induced the reduction whereas the high dose the increase of anxiety in elevated plus maze. The opposite effects of two doses of IL-1 beta were observed also in a test with saccharine.
Zubareva
O E
OE
Institute of Experimental Medicine, Russian Acad. Med. Sci., St. Petersburg, 197376, Acad. Pavlov St., 12, Russia.
Efremov
O M
OM
Simbirtsev
A S
AS
Klimenko
V M
VM
D000818:Animals; D003863:Depression / Q000139:chemically induced / Q000523:psychology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior; D007375:Interleukin-1 / Q000008:administration & dosage / Q000502:physiology; D008297:Male; D018782:Maze Learning; D009043:Motor Activity; D011749:Pyrogens / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012919:Social Behavior
D007375:Interleukin-1; D011749:Pyrogens
Interleĭkin-1beta i depressivnye sostoianiia.