Reactive coupling of poly(ethylene glycol) on electroactive polyaniline films for reduction in protein adsorption and platelet adhesion.
Poly(ethylene glycol) (PEG)-coupled polyaniline (PANI) film surfaces were prepared by incorporating the chlorinie end-capped methoxy PEG (mPEGCl) of molecular weight of about 2000 onto the emeraldine (EM) base form of PANI via N-alkylation. The microstructure and composition of the mPEG-coupled PANI (mPEG-c-PANI) surfaces were characterized by atomic force microscopy, contact angle measurement and X-ray photoelectron spectroscopy. The concentration of surface-coupled mPEG increased with the increase in concentration of the mPEGCl solution. The mPEG-c-PANI film surfaces exhibited enhanced ability to repel protein adsorption, with only an moderate reduction in their electrical conductivity. The mPEG-c-PANI surface with a high concentration of coupled mPEG also exhibited good resistance towards platelet adhesion.
Zhang
Fu
F
Department of Chemical Engineering, National University of Singapore, Singapore.
Kang
E T
ET
Neoh
K G
KG
Wang
Peng
P
Tan
K L
KL
D000327:Adsorption; D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D010973:Platelet Adhesiveness / Q000502:physiology*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013499:Surface Properties
D000814:Aniline Compounds; D020099:Coated Materials, Biocompatible; D011506:Proteins; C416807:polyaniline; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols