title: Effects of adhesives and permeation enhancers on the skin permeation of captopril.
abstract: To formulate a transdermal drug delivery system of captopril, monolithic adhesive matrix type patches containing 20% captopril, different pressure-sensitive adhesives, and various permeation enhancers were prepared using a labcoater. The effects of the adhesives and permeation enhancers on skin permeation of captopril from the prepared patches were evaluated using Franz diffusion cells fitted with excised rat skins. The permeation rate of the drug through the excised skin was dependent on the type of polyacrylate copolymers studied. Fatty alcohols resulted in a pronounced enhancing effect on the skin permeation of captopril, while dimethyl sulfoxide, N-methyl-2-pyrrolidone, oleic acid, Transcutol, and polysorbate 20 showed no significant enhancing effect. The permeation-enhancing effect of the fatty alcohols reached the maximum at the level of 100%. Based on these results, a captopril patch may be developed with further optimization.
authors.affiliation: College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
authors.forename: E S
authors.initials: ES
authors.lastname: Park
authors.forename: S J
authors.initials: SJ
authors.lastname: Chang
authors.forename: Y S
authors.initials: YS
authors.lastname: Rhee
authors.forename: S C
authors.initials: SC
authors.lastname: Chi
mesh_terms: D000179:Acrylates; D000269:Adhesives; D000279:Administration, Cutaneous; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D002216:Captopril / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D005079:Excipients; D005233:Fatty Alcohols / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D000179:Acrylates; D000269:Adhesives; D000806:Angiotensin-Converting Enzyme Inhibitors; D005079:Excipients; D005233:Fatty Alcohols; D002216:Captopril