Synthesis and characterization of (99m)Tc- and (188)Re-complexes with a diamido-dihydroxymethylenephosphine-based bifunctional chelating agent (N(2)P(2)-BFCA).
A diamido-dihydroxymethylenephosphine (N(2)P(2)) bifunction chelating agent (BFCA) was shown to form well-defined (99m)Tc- and (188)Re-chelate structures. The 4, 4-bis [bis-hydroxymethyl-phosphonyl-propylcarbonmoyl]-butyric acid bifunctional chelating agent (N(2)P(2)-BFCA) formed stable complexes with (99m)Tc and (188)Re in >95% yield with high radiochemical purity (RCP). The biodistribution of the (99m)Tc- and (188)Re-N(2)P(2)-BFCAs after intravenous injection studied in normal mice showed the activity was excreted primarily via renal-urinary pathway indicating their use for labeling peptides with (99m)Tc and (188)Re.
Kothari
K K
KK
Radiopharmaceuticals Division, Bhabha Atomic Research Center, Mumbai, India. kanchan@apsara.barc.ernet.in
Gali
H
H
Prabhu
K R
KR
Pillarsetty
N
N
Owen
N K
NK
Katti
K V
KV
Hoffman
T J
TJ
Volkert
W A
WA
D000818:Animals; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D004355:Drug Stability; D051379:Mice; D011868:Radioisotopes; D012211:Rhenium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D017556:Technetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002614:Chelating Agents; D011868:Radioisotopes; D017556:Technetium Compounds; D012211:Rhenium