[Docitaxol-induction apoptosis of osteosarcoma].
OBJECTIVE
To study the growth inhibition and apoptosis induction effect of docitaxol on osteosarcoma cells.


METHODS
The effect of docitaxol on osteosarcomat cell line PL-1 was examined by cell count, morphologic observation, flow cytometry (FCM) and electronmicroscopy.


RESULTS
Docitaxol inhibited the growth of PL-1 in a time and dose-dependent manner. The osteosarcoma cells were blocked at G1 phase of the cell cycle. The treated cells presented features typical of apoptosis. Cells recultured shortly after being treated with docitaxol were more apt to undergo apoptosis than cells treated with docitaxol continuously.


CONCLUSIONS
The growth inhibiting effect of docitaxol is due to its ability to induce apoptosis. It shows great potential in the treatment of osteosarcoma.
Peng
L
L
Institute of Orthopaedics of PLA, Xijing Hospital, Xi'an 710032, China.
Wang
Z
Z
Wang
Q
Q
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis; D002455:Cell Division / Q000187:drug effects; D000077143:Docetaxel; D006801:Humans; D012516:Osteosarcoma / Q000473:pathology*; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000494:pharmacology*; D043823:Taxoids; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel