Cytochrome P450 2D6 genotyping and association with tardive dyskinesia in Chinese schizophrenic patients.
BACKGROUND
The discovery of Cytochrome P450 2D6 (CYP 2D6) polymorphism is implicated in individual differences in drug metabolism rate. Mutation with defective alleles is associated with reduced metabolism of many anti-psychotic drugs metabolized by CYP 2D6. This may contribute to the development of tardive dyskinesia (TD) in patients with prolonged exposure to anti-psychotic drugs.


METHODS
In this controlled study, the genotype of CYP 2D6*10 alleles, movement disorders and clinical characteristics in 38 Chinese schizophrenic patients with TD were compared with 38 age- and sex-matched schizophrenia patients without TD.


RESULTS
There was no significant correlation between CYP 2D6*10 genotypes and TD in men. However, a significant increase in the frequency of CYP 2D6*10 allele was found in female patients with TD.


CONCLUSIONS
The sex differences in CYP 2D6 genotyping and vulnerability to develop TD suggest that a biological predisposition that affects pharmacokinetics may be more significant in women, whereas other factors may be more important in men.
Lam
L C
LC
Department of Psychiatry, the Chinese University of Hong Kong, Kwai Chung Hospital, Hong Kong. cwlam@cuhk.edu.hk
Garcia-Barcelo
M M
MM
Ungvari
G S
GS
Tang
W K
WK
Lam
V K
VK
Kwong
S L
SL
Lau
B S
BS
Kwong
P P
PP
Waye
M M
MM
Chiu
H F
HF
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D044466:Asian People; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D004409:Dyskinesia, Drug-Induced / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*
D014150:Antipsychotic Agents; D019389:Cytochrome P-450 CYP2D6