Absorption of dimethylacetamide (DMAC) following application of a polymer film to the skin of rabbits.
Kapton Film is a polymer with high strength and thermal resistance finding use in a wide variety of applications. In the preparation of this film, the uncured material could contain up to 30% dimethylacetamide (DMAC). Note that the final product Kapton Film has been thermally cured with the DMAC removed. During processing, dermal contact with the film is anticipated, and the possibility exists of DMAC transfer from the uncured film, to and through the skin. In this study, 2 x 2-inch pieces of film were applied to the skin of a group of rabbits and secured in place for a single 4-hour contact time. An amount of liquid DMAC corresponding to the amount contained in the 2-inch square was applied to the skin of a separate group of rabbits for 4 hours. Urine samples were collected over the intervals of application to 4 hours post application (8 hours total) or 4 to 20 hours post application (16 hours). The amount of the urinary metabolite monomethylacetamide (MMAC) was determined analytically in these samples. Urine from 2 untreated rabbits was collected at the same time to serve as controls. The amount of urinary MMAC found in the rabbit rine from animals exposed to uncured Kapton Film at both ollection intervals was similar to the amount seen in the controls (background). Rabbits treated with DMAC liquid had measurable urinary MMAC levels that were approximately 100 times background. It is concluded that, under the conditions of this study, very little, if any, DMAC from the uncured Kapton Film was absorbed through the skin (and excreted in the urine as MMAC).
Finlay
C
C
DuPont Co, Haskell Laboratory, Newark, Delaware, USA.
Malley
L A
LA
Kennedy
G L
GL
D000081:Acetamides / Q000493:pharmacokinetics* / Q000494:pharmacology; D000279:Administration, Cutaneous; D000818:Animals; D008297:Male; D023421:Models, Animal; D011108:Polymers / Q000494:pharmacology*; D011817:Rabbits; D012016:Reference Values; D012680:Sensitivity and Specificity; D012869:Skin Absorption / Q000187:drug effects*; D016482:Urinalysis
D000081:Acetamides; D011108:Polymers; C013959:dimethylacetamide