The unfolding tale of the unfolded protein response.
Surface and secreted proteins are synthesized in the endoplasmic reticulum where they must fold and assemble before being transported. Changes in the ER that interfere with their proper maturation initiate the unfolded protein response pathway. New studies have filled in a missing link between the yeast and mammalian pathways.
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Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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D000818:Animals; D005656:Fungal Proteins / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D017510:Protein Folding; D017346:Protein Serine-Threonine Kinases; D021381:Protein Transport / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction
D005656:Fungal Proteins; D008562:Membrane Glycoproteins; D029701:Saccharomyces cerevisiae Proteins; C082863:IRE1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases