[Effect of xuefu zhuyu decoction on function of platelet and endothelial cell].
OBJECTIVE
To explore the effect of Xuefu Zhuyu Decoction (XFZYD) on function of platelet and endothelial cell.


METHODS
Through incubation of XFZYD, in different concentration, with platelet and human umbilical vein endothelial cell, the platelet membrane glycoprotein II b/III a complex and thrombomoduline (TM) of human umbilical vein endothelial cell were determined by radioimmunoassay.


RESULTS
XFZYD in 40 mg/ml or 80 mg/ml could obviously inhibit the adenosine diphosphate induced glycoprotein II b/III a molecular expression, as compared with the control group, the difference was significant (P < 0.05, P < 0.01), but it did not influence the TM level significantly.


CONCLUSIONS
XFZYD could inhibit the adenosine diphosphate induced activation of platelet through blocking the exposure of glycoprotein II b/III a complex.
Li
Y
Y
First Affiliated Hospital, Tianjin TCM College, Tianjin (300193).
Wang
Z
Z
Weng
J
J
D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism*; D018180:Thrombomodulin / Q000378:metabolism; D014471:Umbilical Veins / Q000166:cytology
D004365:Drugs, Chinese Herbal; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D018180:Thrombomodulin