The influence of T. evansi infection on the immuno-responsiveness of experimentally infected water buffaloes.
In order to define the immuno-suppressive capacity of Trypanosoma evansi infections in buffaloes on the induction of immune responses against heterologous antigens, infected and non-infected buffaloes were vaccinated against Pasteurella multocida (haemorrhagic septicemia) and were simultaneously immunised with a control antigen, human serum albumin (HSA). Antibody responses against HSA were significantly reduced in T. evansi-infected animals, but no conclusive data were obtained on the antibody responses against P. multocida. Conversely, the local inflammatory response at the site of Pasteurella vaccination, as measured by increase in size, was significantly reduced in T. evansi-infected animals. These results indicate that the inductive capacity to mount humoral and cell-mediated immune responses against heterologous antigens is suppressed in T. evansi-infected animals. Consequently, T. evansi infection might interfere with the development of protective immunity upon heterologous vaccinations and could explain the poor protection of Pasteurella-vaccinated buffaloes in T. evansi-endemic areas of Vietnam.
Holland
W G
WG
Faculty of Veterinary Medicine, Laboratory of Parasitology, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.
My
L N
LN
Dung
T V
TV
Thanh
N G
NG
Tam
P T
PT
Vercruysse
J
J
Goddeeris
B M
BM
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000913:Antibodies, Protozoan / Q000096:biosynthesis* / Q000097:blood; D001428:Bacterial Vaccines / Q000276:immunology; D002020:Buffaloes / Q000469:parasitology*; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D007111:Immunity, Cellular; D016979:Pasteurella multocida / Q000276:immunology; D012709:Serum Albumin / Q000276:immunology; D013997:Time Factors; D014345:Trypanosoma / Q000276:immunology*; D014352:Trypanosomiasis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary
D000907:Antibodies, Bacterial; D000913:Antibodies, Protozoan; D001428:Bacterial Vaccines; D012709:Serum Albumin