title: Adenomatoid tumors of the uterus: an analysis of 60 cases.
abstract: Sixty cases of uterine adenomatoid tumors (ATs) are reported. All except four were incidental findings in hysterectomy specimens, three of these being discovered preoperatively as large multicystic tumors. ATs were classified into two distinctive macroscopic patterns: small, solid tumors and large, cystic ones. The 56 small, solid ATs ranged from 0.2 to 3.5 cm, (average 2.1 cm); 48 were nodular and 8 diffuse. The four large, cystic tumors ranged from 7 to 10 cm. Inflammation occurred in 65% of the tumors, and a smooth muscle reaction, identified by an increased Ki-67 index, was present in most cases. Both types were histologically similar except for the presence of short papillae in cystic tumors, which also showed serosal involvement. Both were immunoreactive for cytokeratins, calretinin, HMBE-1, and vimentin. Estrogen and progesterone nuclear receptors and EMA were negative. These tumors represent a spectrum ranging from small and solid to large and cystic ATs in the female genital tract, whereas outside the genital tract they are morphologically similar to multicystic mesothelioma. Although a reactive origin for ATs often seems plausible, especially when inflammation is present, their neoplastic nature should not be ignored.
authors.affiliation: Department of Pathology, University Hospital, Granada, Spain.
authors.forename: Francisco F
authors.initials: FF
authors.lastname: Nogales
authors.forename: María Alejandra
authors.initials: MA
authors.lastname: Isaac
authors.forename: David
authors.initials: D
authors.lastname: Hardisson
authors.forename: Luisanna
authors.initials: L
authors.lastname: Bosincu
authors.forename: José
authors.initials: J
authors.lastname: Palacios
authors.forename: Jaume
authors.initials: J
authors.lastname: Ordi
authors.forename: Eladio
authors.initials: E
authors.lastname: Mendoza
authors.forename: Félix
authors.initials: F
authors.lastname: Manzarbeitia
authors.forename: Helena
authors.initials: H
authors.lastname: Olivera
authors.forename: Francisco
authors.initials: F
authors.lastname: O'Valle
authors.forename: Maja
authors.initials: M
authors.lastname: Krasević
authors.forename: Manuel
authors.initials: M
authors.lastname: Márquez
mesh_terms: D018254:Adenomatoid Tumor / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D064032:Calbindin 2; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000096:biosynthesis; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008875:Middle Aged; D018396:Mucin-1 / Q000096:biosynthesis; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis; D012189:Retrospective Studies; D064030:S100 Calcium Binding Protein G / Q000096:biosynthesis; D018180:Thrombomodulin / Q000096:biosynthesis; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000096:biosynthesis
chemical_list: C576764:CALB2 protein, human; D064032:Calbindin 2; D019394:Ki-67 Antigen; D018396:Mucin-1; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D064030:S100 Calcium Binding Protein G; D018180:Thrombomodulin; D014746:Vimentin; D007633:Keratins