title: The transforming growth factors beta in development and functional differentiation of the mouse mammary gland.
abstract: The transforming growth factors beta (TGF-beta) are multifunctional regulators with diverse effects on a variety of developmental processes and differentiated functions. In the mammary gland, a considerable amount of evidence has accumulated indicating that TGF-beta plays a critical role during several phases of the mammary cycle. TGF-beta regulates growth and patterning of the mammary ductal tree in the virgin mouse. During pregnancy, TGF-beta is required for alveolar development and functional differentiation, while at the same time inhibiting secretion of milk proteins. At parturition this inhibition is lifted, permitting initiation of lactation.
authors.affiliation: Department of Biology, University of California, Santa Cruz 95064, USA.
authors.forename: C W
authors.initials: CW
authors.lastname: Daniel
authors.forename: S
authors.initials: S
authors.lastname: Robinson
authors.forename: G B
authors.initials: GB
authors.lastname: Silberstein
mesh_terms: D000818:Animals; D005260:Female; D015870:Gene Expression; D007774:Lactation; D008321:Mammary Glands, Animal / Q000254:growth & development* / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D011247:Pregnancy; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology*
chemical_list: D016212:Transforming Growth Factor beta