[Effect of Baoyuan Qiangshen capsule no. II on tubular interstitial injury in chronic renal failure patients].
OBJECTIVE
To investigate the protective effect and mechanism of Baoyuan Qiangshen Capsule No. II (BYQS) in treating chronic renal failure (CRF).


METHODS
Sixty patients of CRF were divided into 2 groups randomly, the tested group treated with BYQS combined with Lotensin and the control group treated with essential amino acid combined with Lotensin. Changes of renal function and tubular marked proteins were observed.


RESULTS
The markedly effective rate and total effective rate of the tested group were 63.3% and 93.3% respectively and those of the control group were 30.0% and 56.7% respectively, the effect of the tested group was markedly better than that of the control group (P < 0.01). In the tested group after treatment, BUN, SCr and CCr were improved significantly, urine retinol binding protein and beta 2-microglobulin and N-acetyl-beta-D-glucosamindase decreased significantly (P < 0.01), while Tamm-Horfau protein increased significantly (P < 0.05).


CONCLUSIONS
BYQS could alleviate tubular interstitial injury significantly so as to improve the renal function and enhance the effective rate in treating CRF.
Zhu
P
P
Jiangsu Provincial TCM-WM Center of Nephropathy, Zhenjiang, Jiangsu (212002).
Wei
X
X
Zhao
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012177:Retinol-Binding Proteins / Q000652:urine; D001613:beta 2-Microglobulin / Q000652:urine
D002214:Capsules; D004365:Drugs, Chinese Herbal; D012177:Retinol-Binding Proteins; D001613:beta 2-Microglobulin