title: [The effects of experimental osteoporosis on bone tissues around hydroxyapatite implants].
abstract: OBJECTIVE
  To investigate the effects of estrogen decreasing on bone tissues around implants in ovariectomized rats.
  
  
  METHODS
  Forty-two female Wistar rats, aged 32 weeks, were used in this study. First, cylindrical hydroxyapatite-coated implants were planted in the proximal part of tibiae of the rats. Then, the rats in experimental group and control group were respectively performed ovariectomy and false surgery after 56 days, the rates were killed in 28, 84 and 168 days after operation, and tibiae were taken out to prepare undecalcified sections. The section were examined by routine histomorphometric measurement and the dynamic changes of trabecular bone and extent of contact between the implants and bone tissue around them.
  
  
  RESULTS
  Twenty-eight days after operation, the density of trabecular bone around the implant in experiment group was found significantly reduced compared with the control group. In the area of cortical bone, no difference was found in the extent of implant-bone contact between two groups, while in the area of spongy bone the extent of contact was different obviously.
  
  
  CONCLUSIONS
  Ovariectomy in Wistar rats can induce significant osteoporosis around implant, these finding suggest that menopause in women patients may also induce osteoporosis around implanted artificial teeth and affect the prognosis. Therefore, the patients should be carefully observed during the implant treatment course.
authors.affiliation: Department of Oral Maxillofacial Surgery, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China.
authors.forename: J
authors.initials: J
authors.lastname: Pan
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Qi
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000503:physiopathology*; D015921:Dental Implants / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D010024:Osteoporosis / Q000209:etiology*; D010052:Ovariectomy / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015921:Dental Implants