Platelet receptors for adhesion and activation. Variability as a factor in susceptibility to cardiovascular diseases.
Polymorphisms in coagulation factors leading to altered susceptibility to cardiovascular diseases have been known for some time and some are now well-established risk factors. More recently, an increasing number of polymorphisms have been identified in platelet receptors and a series of studies indicate that these too may play a role as individual risk factors for stroke and myocardial infarction. The effect of these platelet polymorphisms appears less clear-cut than some of the coagulation factor effects and other, associated, risk factors may be important in defining their role. In this review platelet receptor polymorphisms and their role as risk factors are surveyed and their possible relevance discussed.
Clemetson
K J
KJ
Theodor Kocher Institute, University of Berne, Switzerland. clemetson@tki.unibe.ch
D016824:Antigens, Human Platelet / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics; D006801:Humans; D015539:Platelet Activation / Q000235:genetics; D010973:Platelet Adhesiveness / Q000235:genetics; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics; D010980:Platelet Membrane Glycoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic
C044561:3a alloantigen, human; C071092:5a alloantigen, human; D016824:Antigens, Human Platelet; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins