title: Role of CTL host responses and their implication for tumorigenicity testing and the use of tumour cells as vaccine substrate.
abstract: Viral oncogenes, mutated cellular oncogenes, or other adventitious agents that might contaminate vaccine preparations on inoculation of the host will encounter a T cell-mediated immune response which will play a determining role in the progression of neoplastic events or replication of contaminating viral agents. Using SV40 T antigen tumour systems as a model we discuss the regions of the oncoprotein that have an impact on tumourigenicity and the role of CD8 T lymphocyte immune responses in eliminating potential tumour cells. In addition, we discuss measures that counteract T cell immune responses to abrogate T cell-mediated immunosurveillance.
authors.affiliation: Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey 17033, USA.
authors.forename: S
authors.initials: S
authors.lastname: Tevethia
authors.forename: T
authors.initials: T
authors.lastname: Beachy
authors.forename: T
authors.initials: T
authors.lastname: Schell
authors.forename: J
authors.initials: J
authors.lastname: Lippolis
authors.forename: R
authors.initials: R
authors.lastname: Newmaster
authors.forename: L
authors.initials: L
authors.lastname: Mylin
authors.forename: M J
authors.initials: MJ
authors.lastname: Tevethia
mesh_terms: D000818:Animals; D002460:Cell Line; D005814:Genes, Viral; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D009857:Oncogenes; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines