[Correlation of asymptomatic bronchial hyperresponsiveness with serum specific IgE and eosinophilic cation protein].
OBJECTIVE
To explore the correlation of asymptomatic bronchial hyperresponsiveness with serum specific IgE(sIgE) and eosinophilic cation protein(ECP).


METHODS
Histamine inhalation provoking test (quantitative method) was used in a survey for bronchial responsiveress in 1,123 students aged between 11 to 14 years old, 41 individuals with asymptomatic bronchial hyperresponsiveness received further test for sIgE and ECP. 31 students with normal bronchial responsiveness were randomly selected as the control.


RESULTS
4%(41/1,123) of the students showed bronchial hyperresponsiveness. The incidence of bronchial hyperresponsiveness with family history of asthma (11/14, 79%) was higher than that without a family history (30/1,109, 3%), with statistical significance (P < 0.005). The positive rates for sigE (90%, 37/41, P < 0.01) and ECP (17%, 7/41, P < 0.05), sIgE q value (14.3 +/- 12.1) micrograms/L, (P < 0.01) and ECP value (44.3 +/- 60.2) micrograms/L, (P < 0.01) in asymptomatic bronchial hyperresponsiveness group were higher than those of the control with statistical significance. His PD20-FEV1 was negatively related to aIgE q value (P < 0.05) and not related to ECP (P > 0.05).


CONCLUSIONS
The asymptomatic bronchial hyperresponsiveness was closely related to allergy but not to ECP. Those with a family history of asthma, or with positive sIgE should be followed.
Deng
N
N
Peoples Hospital of Dongguan, Dongguan 523000, China.
Wang
Q
Q
Wan
D
D
D000293:Adolescent; D001249:Asthma / Q000097:blood / Q000235:genetics / Q000503:physiopathology*; D001798:Blood Proteins / Q000378:metabolism*; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000235:genetics / Q000503:physiopathology*; D002648:Child; D047091:Eosinophil Granule Proteins; D005192:Family Health; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D012260:Ribonucleases
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D007073:Immunoglobulin E; D012260:Ribonucleases