title: Chromosome 11 copy number gains and Epstein-Barr virus-associated malignancies.
abstract: Epstein-Barr virus (EBV) genome can be found in many malignant tumors in China. Previous data of interphase cytogenetics, by comparative genomic hybridization and/or fluorescence in situ hybridization, on nasopharyngeal carcinomas and natural killer cell-type non-Hodgkin lymphomas in Hong Kong have noted gains in chromosome 11. This study compares the frequency of chromosome 11 copy number gains in three different types of EBV-associated tumors in Hong Kong. Using alpha-satellite probes, the authors studied by fluorescence in situ hybridization 31 EBV-positive tumors comprising 10 EBV-positive gastric carcinomas, 8 lung lymphoepithelioma-like carcinomas, and 13 non-Hodgkin lymphomas. Trisomy or polysomy 11 was detected in 10 of 10 (100%) EBV-positive gastric carcinomas, 6 of 8 (75%) lung lymphoepithelioma-like carcinomas, and 4 of 13 (30.8%) non-Hodgkin lymphomas. Compared with the EBV-positive gastric carcinomas, the 10 EBV-negative gastric carcinomas that were also studied showed chromosome 11 copy number gains in 3 of 10 (30%), a significantly lower frequency. The authors conclude that gains in chromosome 11 are common in EBV-associated malignancies in Hong Kong, with the strongest association found in gastric carcinoma. There seems to be differences between EBV-associated tumors of different locations, and between gastric carcinomas with and without EBV.
authors.affiliation: Department of Anatomical & Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT. wingchan@cuhk.edu.hk
authors.forename: W Y
authors.initials: WY
authors.lastname: Chan
authors.forename: A B
authors.initials: AB
authors.lastname: Chan
authors.forename: A Y
authors.initials: AY
authors.lastname: Liu
authors.forename: J H
authors.initials: JH
authors.lastname: Chow
authors.forename: E K
authors.initials: EK
authors.lastname: Ng
authors.forename: S S
authors.initials: SS
authors.lastname: Chung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002277:Carcinoma / Q000235:genetics / Q000473:pathology / Q000821:virology; D002880:Chromosomes, Human, Pair 11; D004273:DNA, Neoplasm / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D018628:Gene Dosage; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000821:virology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology
chemical_list: D004273:DNA, Neoplasm; D012367:RNA, Viral