[Detection and effect of telomerase activity in oral mucosal squamous cell carcinoma].
OBJECTIVE
To study telomerase activity in 20 oral squamous cell carcinoma(SCC), and 10 normal oral tissues and 9 oral SCC and 9 adjacent normal tissue.


METHODS
A modified PCR-based telomeric repeat amplification protocal assay(TRAP) was used.


RESULTS
The telomerase activity was significantly higher in SCC than that of normal mucosa, and than that of adjacent tissue as well.


CONCLUSIONS
These findings indicated that telomerase activation might be a critical step in the formation and development of cancer.
Yao
H
H
Department of Stomatology, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, China.
Wu
B
B
Wu
Q
Q
D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000473:pathology; D016133:Polymerase Chain Reaction; D019098:Telomerase / Q000235:genetics / Q000378:metabolism*
D019098:Telomerase