title: [Sensitivity, specificity and prognostic value of CEA in colorectal cancer: results of a Tunisian series and literature review].
abstract: In order to determine the sensitivity of CEA in the diagnosis of colo-rectal carcinoma, we studied a series of 48 patients with colo-rectal carcinoma (1992-1996). The sensitivity was at 52% with a reference value of 5 ng/ml and 68.7% for a reference value of 2.5 ng/ml. With a reference value of 5 ng/ml, the sensitivity of CEA was at 37% only for patients with colo-rectal carcinoma at Dukes B stage, 66.6% for patients at stage C and 75% for patients at stage D. The dosage of CEA was carried out with a sandwich immunoenzymatic technique in tube. There is no statistic significant correlation between the pre-operative rate of CEA and the localisation of the tumor and its histologic type; in contrast, it was significantly correlated with the ganglionnary metastasis. A significant relationship between the pre-operative rate of CEA and the Dukes stage was found for a reference value of 10 ng/ml but not for a reference value of 5 ng/ml. We calculated the specificity of the CEA for the cancers of colon and rectum which was at 76.98% with a reference value of 5 ng/ml and 86% with a reference value of 10 ng/ml.
authors.affiliation: Laboratoire d'Immunologie, CHU Habib Bourguiba Sfax.
authors.forename: Y
authors.initials: Y
authors.lastname: Bel Hadj Hmida
authors.forename: N
authors.initials: N
authors.lastname: Tahri
authors.forename: A
authors.initials: A
authors.lastname: Sellami
authors.forename: N
authors.initials: N
authors.lastname: Yangui
authors.forename: R
authors.initials: R
authors.lastname: Jlidi
authors.forename: M I
authors.initials: MI
authors.lastname: Beyrouti
authors.forename: M S
authors.initials: MS
authors.lastname: Krichen
authors.forename: H
authors.initials: H
authors.lastname: Masmoudi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D002272:Carcinoembryonic Antigen
vernacular_title: Sensibilite, specificite et valeur pronostique de l'ace dans le cancer du colon rectum: resultats d'une série Tunisienne et revue de la littérature.