Hybridization properties of aromatic peptide nucleic acids: a novel class of oligonucleotide analogues.
[structure: see text] The synthesis of APNA-PNA chimeras containing all four DNA bases will be described. The hybridization properties of APNA-PNA chimeras with DNA and RNA are consistent with plausible intramolecular interactions that could preorganize the oligomers in a duplex or triplex structure with complementary DNA or RNA.
Fader
Lee D
LD
Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6.
Tsantrizos
Youla S
YS
D004247:DNA / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D012313:RNA / Q000737:chemistry
D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D012313:RNA; D004247:DNA