title: [Evaluation of methods of detection for prostate neoplasm].
abstract: OBJECTIVE
  To evaluate the significance of serum prostate specific antigen (PSA), digital rectal examination (DRE), transrectal ultrasound (TRUS) and magnetic resonance imaging (MRI) as guide to perform prostate needle biopsy.
  
  
  METHODS
  One hundred forty-eight patients suspicious of prostate neoplasm were undergone transrectal ultrasound-guided prostate needle biopsy. The pathologic diagnosis was analyzed in association with the results of PSA, DRE, TRUS and MRI in various combinations.
  
  
  RESULTS
  The positive rate of biopsy was 43.9%. While abnormal DRE or PSA contributed in the detection of prostate cancer, serum PSA became more reliable when combined with DRE, TRUS or MRI, but the contribution of each of the three diagnostic procedures was not significantly different. The sensitivity of MRI was higher than that of DRE or TRUS, whereas TRUS was more specific than PSA or MRI.
  
  
  CONCLUSIONS
  RE and PSA can be used for preliminary screening of prostate cancer. When combined with TRUS and MRI, the positive rate of diagnosis is increased. So is the specificity of the diagnosis which helps avoid unnecessary needle biopsy.
authors.affiliation: Beijing Hospital, Beijing 100730, China.
authors.forename: C
authors.initials: C
authors.lastname: Zhong
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: B
authors.initials: B
authors.lastname: Wan
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D005069:Evaluation Studies as Topic; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen