[Effects of nitric oxide (NO) on the cardiac function in severely scalded rats].
OBJECTIVE
To investigate the effects of NO on the cardiac function in severely scalded rats and to elucidate its mechanism.


METHODS
Ninety Sprague-Dawley (SD) rats inflicted with 30% TBSA III degree scalding were employed as the model and divided randomly into five groups, i.e. burn (B), shamburn (SB), L-arginine (L-Arg), N-nitroso-L-argininemethylester (L-NAME) and L-Arg + L-NAME groups. Cardiac functional indices, myocardial content of malondialdehyde (MDA) and myocardial Ca (calcium) transport were examined in the rats of all the groups, respectively.


RESULTS
Compared to those in B group, the mean arterial pressure (MAP), left ventricular summit pressure (LVSP), the +/- dp/dt max in left ventricle pressure and the cardiac Lo in L-NAME group increased obviously. While those in L-Arg group decreased significantly but those in L-Arg + L-NAME group exhibited no remarkable change. The MDA content in L-NAME group was evidently lower than that in B group, while the calcium transport index of sarcoplasmic reticulum in L-NAME group increased obviously.


CONCLUSIONS
Nitric oxide, massively produced postburn, exerted inhibitory effects on cardiac function by means of the cytotoxicity of its owns and other free radicals, which might be closely related to the decrease of its calcium transport function of sarcoplasmic reticulum.
Wang
T
T
Department of Burns, General Worker's Hospital, Panzhihua Steel and Iron Company, Panzhihua 617023, Sichuan Province, P. R. China.
He
W
W
Chen
Y
Y
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002056:Burns / Q000473:pathology* / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D004357:Drug Synergism; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013599:Systole; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects
D009569:Nitric Oxide; D008315:Malondialdehyde; D001120:Arginine; D002118:Calcium; D019331:NG-Nitroarginine Methyl Ester