title: Diasteroselective cyclizations with enantiopure malonaldehyde monocycloacetals.
abstract: The synthesis of a series of enantiopure malonaldehyde monocycloacetals is described. Treatment of 8b with L-tryptophan methyl ester, 5-methoxytryptamine, and tryptamine, respectively, in the Pictet-Spengler condensation gave the corresponding enantiomerically pure key precursors 1-3 and 17-21 in only two steps. Using a chiral amino-diol successfully realized the kinetic resolution of racemic carbolines 23 and 24.
authors.affiliation: College of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China.
authors.forename: Lanrong
authors.initials: L
authors.lastname: Bi
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Shiqi
authors.initials: S
authors.lastname: Peng
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Winterfeldt