title: [Computer analysis and recognition of Drosophila melanogaster gene promoters].
abstract: A new method for recognizing eukaryotic gene promoters was based on their partition and on analysis of correlations of dinucleotide frequencies for each individual fragment. The method was used to recognize the TATA-containing and TATA-less promoters of Drosophila melanogaster genes. Dinucleotide context was correlated with conformational and physicochemical DNA properties in promoter fragments. Mean values of several parameters proved to dramatically change on transition from the TATA box to its GC-rich flanks. In TATA-less promoters, specific properties were revealed in the DPE region. The method was employed in a promoter recognition program, which is available through Internet.
authors.affiliation: levitsky@bionet.nsc.ru
authors.forename: V G
authors.initials: VG
authors.lastname: Levitskiĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Katokhin
mesh_terms: D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D011401:Promoter Regions, Genetic; D016385:TATA Box
chemical_list: D004247:DNA
vernacular_title: Komp'iuternyĭ analiz i raspoznavanie promotorov genov Drosophila melanogaster.