[Antitoxic properties of hepazan--a novel inducer of microsomal enzyme system].
The antitoxic properties of hepazan (dihydrothiazolexanthine), a new inductor of the microsomal enzyme system (MES) of liver were studied in white mice with the MES disorder induced by P. Aeruginosa toxin. It was found that hepazan not only eliminates the toxin-induced depression, but also decreases the toxic effects of ketoconazole, digoxin, and propranolol under the toxinemia conditions.
Gazizova
I R
IR
Pharmacology Department, Bashkir State Medical University, ul. Lenina 3, Ufa, Bashkortostan, 450000 Russia.
Nikitina
I L
IL
Alekhin
E K
EK
D000818:Animals; D001427:Bacterial Toxins; D004077:Digoxin / Q000633:toxicity; D004336:Drug Antagonism; D004790:Enzyme Induction; D007654:Ketoconazole / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D011433:Propranolol / Q000633:toxicity; D011550:Pseudomonas aeruginosa; D014966:Xanthenes / Q000633:toxicity*
D001427:Bacterial Toxins; D014966:Xanthenes; D004077:Digoxin; D011433:Propranolol; D007654:Ketoconazole
Antitoksicheskie svoĭstva novogo induktora mikrosomal'noĭ fermentnoĭ sistemy gepazana.