Opposite effects of mast cell degranulation by compound 48/80 on peritoneal inflammation in Swiss and CBA mice.
The murine strains differ in the number of peritoneal mast cells. Degranulation of peritoneal mast cells by single injection of compound 48/80 (1.2 mg/kg) followed by zymosan-induced (2 mg/ml, 0.5 ml/mouse) peritoneal inflammation caused either inhibition or enhancement of an early influx (at 4 h of peritonitis) of exudatory leukocytes in Swiss and CBA mice, respectively. These opposite effects correspond with statistically significant differences in the number of peritoneal mast cells in the intact Swiss (11 x 10(3)) and CBA (39 x 10(3)) mice.
Stankiewicz
E
E
Department of Evolutionary Immunology, Institute of Zoology, Jagiellonian University, Kraków, Poland.
Wypasek
E
E
Plytycz
B
B
D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010538:Peritonitis / Q000139:chemically induced / Q000473:pathology*; D013045:Species Specificity; D003189:p-Methoxy-N-methylphenethylamine / Q000009:adverse effects*
D003189:p-Methoxy-N-methylphenethylamine