title: Experimental study on size matching in a canine living-donor lobar lung transplant model.
abstract: OBJECTIVE
  In an effort to address the donor-shortage issue, living-donor lobar lung transplants have been performed with satisfactory results. The use of small grafts is potentially problematic because it could cause high pulmonary artery pressure, resulting in lung edema. The purpose of this study was to evaluate the effect of small grafts on early pulmonary function and to identify the predictor for acceptable size discrepancy.
  
  
  METHODS
  Seventeen pairs of mongrel dogs with various donor-recipient sizes were used. Body weight, height, chest circumference, and lung weight were measured as size parameters. Right middle, lower, and cardiac lobes were implanted as a right lung of the recipient and the left lower lobe was implanted as a left lung without use of cardiopulmonary bypass. Pulmonary function of the recipient was measured for 6 hours after reperfusion.
  
  
  RESULTS
  A significant negative correlation was found between donor/recipient body-weight ratio and mean pulmonary artery pressure at 1 hour (r = -0.594, P =.025). A significant correlation was found between donor/recipient body-weight ratio and PaO(2) at 6 hours (r = 0.704; P =.007). There was no significant correlation between the other 3 size parameters and postoperative pulmonary function. All 8 recipients with a donor/recipient body-weight ratio of 1.2 or greater survived the 6-hour assessment period, and their PaO(2) exceeded 500 mm Hg at 6 hours.
  
  
  CONCLUSIONS
  Donor/recipient weight ratio is an important predictor of early pulmonary function in a canine living-donor lobar lung transplant model.
authors.affiliation: Department of Surgery II, Okayama University School of Medicine, Okayama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
authors.forename: Kouji
authors.initials: K
authors.lastname: Ueda
authors.forename: Itaru
authors.initials: I
authors.lastname: Nagahiro
authors.forename: Motoi
authors.initials: M
authors.lastname: Aoe
authors.forename: Akio
authors.initials: A
authors.lastname: Andou
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D000886:Anthropometry; D001794:Blood Pressure; D001824:Body Constitution; D001827:Body Height; D001835:Body Weight; D002496:Central Venous Pressure; D004285:Dogs; D019520:Living Donors; D008168:Lung / Q000033:anatomy & histology / Q000503:physiopathology; D016040:Lung Transplantation; D009929:Organ Size; D011651:Pulmonary Artery; D011659:Pulmonary Gas Exchange; D013909:Thorax / Q000033:anatomy & histology