title: [Morphological changes and quantitative DNA analysis of Schwann cells in peripheral nerves after high voltage electrical injury].
abstract: OBJECTIVE
  To explore the characteristics and the mechanism of the injury of Schwann cells and nerve fibres of the peripheral nerves inflicted by high voltage electricity.
  
  
  METHODS
  Rabbits injured by high voltage electricity were employed as the model. Thirty rabbits were randomly divided into control (9) and experimental (21) groups. The dynamic quantitative DNA analysis and the change of the morphology and structure of the sciatic nerve were observed with LM and EM on 0, 3, 7, 10, 14 and 21 postburn days (PBDs), respectively.
  
  
  RESULTS
  There was continuous degeneration of the axon and medullary sheath of sciatic nerve tissue and its neogenesis was inhibited. The DNA synthesis in Schwann cell initiated on 3 postburn day (PBD). The distribution of the current was heterogeneous on the cross section of peripheral nerve fibres.
  
  
  CONCLUSIONS
  The obvious features of peripheral nerve injured by high voltage electricity included delayed initiation of the DNA synthesis of Schwann cell and the secondary necrosis and inhibition of neogenesis process of Schwann cell.
authors.affiliation: Department of Burns and Plastic Surgery, Shanghai Electric Power Hospital, Shanghai 200050, P. R. China.
authors.forename: X
authors.initials: X
authors.lastname: Xin
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: W
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002058:Burns, Electric / Q000235:genetics / Q000473:pathology*; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000378:metabolism*; D011817:Rabbits; D012583:Schwann Cells / Q000378:metabolism* / Q000473:pathology; D012584:Sciatic Nerve / Q000293:injuries / Q000378:metabolism
chemical_list: D004247:DNA