title: Magnetic resonance imaging in distinguishing malignant from benign pleural disease.
abstract: OBJECTIVE
  To explore the role of magnetic resonance imaging (MRI) in distinguishing malignant from benign pleural disease.
  
  
  METHODS
  All 64 patients were examined with both computed tomography (CT) and MRI. The morphologic features of pleural lesions and MR signal intensity on T1-weighted, T2-weighted and contrast-enhanced T1-weighted images were evaluated.
  
  
  RESULTS
  Mediastinal pleural involvement, circumferential pleural thickening, nodularity, irregularity of pleural contour, and infiltration of the chest wall and/or diaphragm were most suggestive of a malignant cause on CT and MR images. Contrary to what has been reported in the literature, pleural thickness greater than 1 cm either on CT or on MRI did not reveal a significant difference between malignant and benign pleural disease (P > 0.05, chi-square test). Using morphologic features in combination with signal intensity features, MRI had a sensitivity of 98% and a specificity of 92% in the detection of pleural malignancy.
  
  
  CONCLUSIONS
  Compared with those on CT, the morphologic features on MRI allowed a mostly equal and in some cases superior detection and evaluation of the spread of pleural disease. In combination with signal intensity and morphologic features, MRI is very useful in distinguishing malignant from benign pleural disease.
authors.affiliation: Medical Imaging Center, First Affiliated Hospital, Jinan University Medical College, Guangzhou 510630, China. tluolp@jnu.edu.cn
authors.forename: L
authors.initials: L
authors.lastname: Luo
authors.forename: J
authors.initials: J
authors.lastname: Hierholzer
authors.forename: R C
authors.initials: RC
authors.lastname: Bittner
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010994:Pleura / Q000000981:diagnostic imaging / Q000473:pathology*; D010995:Pleural Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed