Acute and chronic toxicity of fessoukh, the resinous gum of Ferula communis L, compared to warfarin.
The acute toxicity of the fessoukh extract (FE) was studied in rats and mice. In single oral dose administration mode, FE has moderate toxicity; the LD50s were 1650 mg/kg bw in rats and 2000 mg/kg bw in mice. In albino rats, with baits containing 0.01 to 10% FE, 0.01% produced 100% mortality in 15 d; with 0.1%, all rats died in 9 d. Baits containing 0.1% were toxic, more consumed, required less product and did not cause apprehension in the rats. A trial conducted with wild rats (Rattus norvegicus) using 0.1% FE baits demonstrated fessoukh's rodenticide effects.
Fraigui
O
O
Département de Pharmacognosie, Faculté de Médecine et de Pharmacie, Rabat-Instituts, Maroc.
Lamnaouer
D
D
Faouzi
M Y
MY
Cherrah
Y
Y
Tijjane
M
M
D000284:Administration, Oral; D000818:Animals; D000925:Anticoagulants / Q000633:toxicity*; D005260:Female; D005309:Ferula / Q000737:chemistry*; D008297:Male; D051379:Mice; D018514:Plant Structures / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012116:Resins, Plant / Q000633:toxicity; D014859:Warfarin / Q000633:toxicity*
D000925:Anticoagulants; D012116:Resins, Plant; D014859:Warfarin