Insulin-like growth factor-I (IGF-I) in serum and bone tissue during rat mandible fracture healing.
Insulin-like growth factor-I (IGF-I) is potent stimulator of proliferation and differentiation of osteoblasts, the biosynthesis of collagen type-I and noncollagenous proteins and alkaline phosphatase activity. The role of IGF-I in bone repair has not as yet been clearly defined. The aim of the present study was the quantitative analysis of IGF-I in the serum and tissue in four phases of fractured jaws healing in rat models. IGF-I concentrations in the serum and bone extracts were determined by RIA. In respect to the control group (K) the significant increase of IGF-I occurred in the serum in phase I (211 +/- 68 ng/ml, K-153 +/- 50 ng/ml) (p < 0.05). At the tissue levels a statistically significant increase in IGF-I was confirmed in phase II (262 +/- 60 ng/g, K-182 +/- 56 ng/g) (p < 0.05). The present results demonstrate that in rat models with fractured jaws in the first two phases of healing elevated levels of IGF-I in the serum and bone tissue were observed which indicate the significant role of this polypeptide in the early healing stages.
Dryl
D
D
Department of Maxillofacial Surgery, Medical Academy of Białystok, Białystok, Poland.
Grabowska
S Z
SZ
Citko
A
A
Pałka
J
J
Antonowicz
B
B
Rogowski
F
F
D000818:Animals; D017102:Fracture Healing / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008337:Mandibular Fractures / Q000097:blood / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D007334:Insulin-Like Growth Factor I