[Antioxidant and antiarrhythmic activity of carvedilol in patients with ischemic heart disease. Comparison with anaprilin].
OBJECTIVE
To examine antioxidant and antiarrhythmic activity of carvedilol vs that of standard beta-blocker anaprilin in coronary patients with low left ventricular ejection fraction (LVEF).


METHODS
The cross-over trial enrolled 50 coronary male patients with LVEF under 45%. Before and after treatment with carvedilol and anaprilin, measurements were made of blood dienic conjugates and malonic dialdehyde, 24-h ECG monitoring was performed.


RESULTS
The antioxidant activity of antiarrhythmic effect of carvedilol was significantly higher than that of anaprilin. A correlation was discovered between the number of extrasystoles and blood levels of dienic conjugates.


CONCLUSIONS
Marked antioxidant activity of carvedilol as well as reduced myocardial energy consumption resultant from hemodynamic cardiac unloading due to block of alpha-adrenoreceptors contribute to carvedilol additional antiarrhythmic effect.
Vasil'ev
A P
AP
Strel'tsova
N N
NN
Gorbunova
T Iu
TIu
Mal'tseva
I A
IA
Zykova
E L
EL
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000150:complications; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D010919:Placebos; D011412:Propanolamines / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D012598:Sclerosis; D016037:Single-Blind Method; D018487:Ventricular Dysfunction, Left / Q000150:complications
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D002227:Carbazoles; D010919:Placebos; D011412:Propanolamines; D000077261:Carvedilol; D011433:Propranolol
Antioksidantnaia i antiaritmicheskaia aktivnost' karvedilola u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.