title: [Properties of artificial evolution of proteins and peptides].
abstract: In vitro evolution is used to study protein sequences, structures, and interactions and to obtain proteins with new properties. To analyze the specific features of this process in experiments with phage display, we studied the amino acid composition of selected sequences, constructed a matrix of amino acid substitutions, and identified pairs of coadaptive substitutions. Amino acid frequency proved to be tightly associated with the number of corresponding codons; numerous correlated substitutions were found.
authors.affiliation: valuev@bionet.nsc.ru
authors.forename: V P
authors.initials: VP
authors.lastname: Valuev
authors.forename: D A
authors.initials: DA
authors.lastname: Afoninkov
authors.forename: O I
authors.initials: OI
authors.lastname: Petrenko
authors.forename: D A
authors.initials: DA
authors.lastname: Grigorovich
mesh_terms: D019943:Amino Acid Substitution; D019143:Evolution, Molecular; D010455:Peptides / Q000737:chemistry / Q000235:genetics*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D010455:Peptides; D011506:Proteins
vernacular_title: Issledovanie svoĭstv iskusstvenno évoliutsii belkov i peptidov.