title: [The follow-up of 12 pregnant women with anticoagulation therapy after mechanical heart valve replacement].
abstract: OBJECTIVE
  The article discusses the effect of warfarin on pregnant women and their fetus, and the methods of anticoagulation therapy during pregnancy.
  
  
  METHODS
  The pregnancy, delivery, and anticoagulation therapy of 12 pregnant women with mechanical heart valve replacement were followed-up.
  
  
  RESULTS
  All the patients received oral anticoagulant therapy during pregnancy. The mean dose of imported warfarin was (2.71 +/- 1.24) mg/d (4 cases); domestic warfarin, (3.14 +/- 0.28) mg/d (6 cases); domestic acenocumarol tablet (3.14 +/- 1.08) mg/d (2 cases). No thromboembolism and major hemorrhage occurred. A total of 8 person/times had minor bleeding. Ten patients had term delivery, 2 had premature birth, No abnormal fetus was observed. Only 1 newborn had low birth weight (2,100 g).
  
  
  CONCLUSIONS
  The anticoagulation therapy with low dosage of warfarin (< 5 mg/d) is safe and convenient for the mothers during pregnancy following mechanical heart valve replacement and has low fetus abnormal rate.
authors.affiliation: Department of Thoracic Cardiovascular Surgery, First Affiliated Hospital of West China University of Medical Sciences, Chengdu 610041, China.
authors.forename: L
authors.initials: L
authors.lastname: Dong
authors.forename: Y
authors.initials: Y
authors.lastname: Shi
authors.forename: Z
authors.initials: Z
authors.lastname: Tian
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D001724:Birth Weight; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000601:surgery*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin