[Clinicopathologic criteria for the diagnosis of extranodal anaplastic large-cell lymphoma: a preliminary study].
OBJECTIVE
To study and observe the clinicopathologic features of extranodal Ki-1 (CD30) positive anaplastic large-cell lymphoma (ALCL) in order to assess its diagnostic criteria.


METHODS
Lymph nodes of 12 patients with Ki-1 positive ALCL were examined histopathologically and immunohistochemically.


RESULTS
There were distinctive histopathological features of ALCL cells. Immunohistochemical staining revealed that all of the ALCL were Ki-1 positive (CD30 or Ber-H2). Of them, 5 cases were leucocyte common antigen (LCA) and epithelial membrane antigen (EMA) positive, 2 cases were LCA negative and EMA positive, 1 case was LCA positive and EMA negative, and the other 4 cases were both negative. Seven cases (58.3%) showed B cell markers, 2 cases (16.7%) showed T cell markers and remaining 3 cases had neither T nor B markers.


CONCLUSIONS
Extranodal Ki-1 (CD30) positive ALCL has distinctive histopathologic and immunohistochemical features which help its differential diagnosis.
Ji
T
T
Department of Pathology, Fuzhou General Hospital of PLA, Fuzhou 350025, China.
Yao
L
L
Deng
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000708:Anaplasia; D002648:Child; D050701:E2F6 Transcription Factor; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012097:Repressor Proteins / Q000032:analysis; D014157:Transcription Factors / Q000032:analysis
D050701:E2F6 Transcription Factor; C491744:E2F6 protein, human; D017730:Ki-1 Antigen; D012097:Repressor Proteins; D014157:Transcription Factors