Dorsal pancreas agenesis in N-cadherin- deficient mice.
Members of the cadherin family of cell adhesion molecules are thought to be crucial regulators of tissue patterning and organogenesis. During pancreatic ontogeny N-cadherin is initially expressed in the pancreatic mesenchyme and later in pancreatic endoderm. Analysis of N-cadherin-deficient mice revealed that these mice suffer from selective agenesis of the dorsal pancreas. Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme.
Esni
F
F
Department of Medical Biochemistry, Box 440, Göteborg University, Göteborg, S-405 30, Sweden.
Johansson
B R
BR
Radice
G L
GL
Semb
H
H
D000818:Animals; D017209:Apoptosis; D015820:Cadherins / Q000235:genetics* / Q000502:physiology*; D002448:Cell Adhesion; D002454:Cell Differentiation; D004707:Endoderm / Q000378:metabolism; D005838:Genotype; D006579:Heterozygote; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D020287:In Situ Nick-End Labeling; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008854:Microscopy, Electron; D009154:Mutation; D010179:Pancreas / Q000196:embryology / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D015820:Cadherins