Effect of different single-bottle dentin adhesives on vascular responses in rat carotid artery.
OBJECTIVE
To investigate the effect of one-bottle dentin bonding systems on pulpal hemorrhage control in direct pulp exposures through contraction of pulp blood vessels using the rat carotid artery model.


METHODS
Four dentin bonding agents (Prime & Bond 2.1, Prime & Bond NT, Syntac Single Component and Single Bond) were used. The efficacy of bonding agents were compared to that of epinephrine (control) in the viewpoint of the concentration applied and the contraction forces induced on the smooth muscle were recorded using a force displacement transducer.


RESULTS
Three of the test materials produced epinephrine-like contractions on the rat carotid artery (smooth muscle) while no reading could be achieved with Single Bond. A ranking between the bonding agents for contraction forces was obtained as follows: Prime & Bond NT > Prime & Bond 2.1 > Syntac Single Component (P < 0.05).
Taşman
F
F
Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey. zaferc@hotmail.com
Cehreli
Z C
ZC
Onur
M A
MA
Gümrükçüoglu
A
A
D000704:Analysis of Variance; D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate / Q000494:pharmacology; D002339:Carotid Arteries / Q000187:drug effects*; D046508:Culture Techniques; D017220:Dentin-Bonding Agents / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D023421:Models, Animal; D009115:Muridae; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011109:Polymethacrylic Acids / Q000494:pharmacology; D019279:Resin Cements / Q000494:pharmacology; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D014159:Transducers; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D017220:Dentin-Bonding Agents; D011109:Polymethacrylic Acids; C103500:Prime & Bond; C425843:Prime and Bond NT; D019279:Resin Cements; C078484:Syntac dentine adhesive; D014662:Vasoconstrictor Agents; C115612:single bond; D017438:Bisphenol A-Glycidyl Methacrylate; D004837:Epinephrine