[Improvement and application of multi-infarct dementia model in rats].
OBJECTIVE
To improve the method of inducing the multi-infarct dementia (MID) model in rats to observe the pharmacodynamic effect of Jiannao Yizhi (JNYZ) granule on MID.


METHODS
Retrograde injection with the homologous embolus through the external carotid artery initiated the multi-infarct dementia in rats. The experiment of behavior and morphology were conducted.


RESULTS
The extensive and multiple foci of infarction and the obviously declining ability of learning and memory were observed in the model group; the action of JNYZ granule and hydergine could obviously improve them.


CONCLUSIONS
This model is useful to carry out basic research and screen new drugs in treating MID.
Mei
J
J
Tianjin College of Traditional Chinese Medicine, Tianjin (300193).
Zhang
Y
Y
Zhang
B
B
D000818:Animals; D015161:Dementia, Multi-Infarct / Q000503:physiopathology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal