[Effect of Yiqi Zishen granule on ultrastructure of glomeruli of IgA nephropathy in mice].
OBJECTIVE
To study the effect and therapeutical mechanism of Yiqi Zishen granule (YQZSG) in treating IgA nephropathy.


METHODS
One hundred and fifty mice were divided into 5 groups randomly, in every treatment group, the relevant drugs were given. Their kidney tissues were observed with light microscope and electron microscope in batches at the 3rd, 6th, 9th and 12th week.


RESULTS
The glomerular mesangial cells and mesangial matrix were proliferative in the model group at the 6th, 9th and 12th week. The light density of glomeruli, the mesangial area, the numeral density of mesangial cells and the light density of mesangial matrix in the model group were obviously higher, the change of large and small dosage YQZSG group and positive Chinese drug group were similar, but milder in pathological degree. The light density of glomerulus area, the mesangial area, the numeral density of mesangial cells and the light density of mesangial matrix in large dosage YQZSG group were significantly lower than those in the model group (P < 0.05 or P < 0.01).


CONCLUSIONS
YQZSG could inhibit the proliferation of mesangial cells and the mesangial matrix in IgA nephropathy.
Nie
L
L
Xiyuan Hospital, China Academy of TCM, Beijing (100091).
Yu
R
R
Lin
X
X
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005920:Glomerular Mesangium / Q000648:ultrastructure*; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D008297:Male; D051379:Mice; D011897:Random Allocation
D004365:Drugs, Chinese Herbal