Herbal complex suppresses telomerase activity in chemo-endocrine resistant cancer cell lines.
A herbal complex consisting of Hoelen, Angelicae radix, Scutellariae radix and Glycyrrhizae radix suppressed cell viability and telomerase activity in hormone-refractory and chemo-resistant cancer cell lines, namely poorly differentiated uterine endometrial cancer cell line AN3 CA, adriamycin-resistant breast cancer cell line MCF7/ADR and cisplatin-resistant ovarian cancer cell line A2780. Furthermore, the herbal complex suppressed the expression of the full length of human telomerase reverse transcriptase (hTERT), which is related to telomerase activity. This indicates that the herbal complex can suppress the tumor growth of chemoendocrine resistant cancers, at least in part via suppression of telomerase activity associated with down-regulated hTERT.
Lian
Z
Z
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan.
Fujimoto
J
J
Yokoyama
Y
Y
Niwa
K
K
Tamaya
T
T
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D002945:Cisplatin / Q000627:therapeutic use; D004268:DNA-Binding Proteins; D004317:Doxorubicin / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D066298:In Vitro Techniques; D016133:Polymerase Chain Reaction; D019098:Telomerase / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D004365:Drugs, Chinese Herbal; D004317:Doxorubicin; D019098:Telomerase; D002945:Cisplatin