title: Lethal catatonia responding to high-dose olanzapine therapy.
abstract: We present the case of a 31-year-old woman with recent refractory bipolar disorder who developed a malignant syndrome preceded by catatonic motor features. This resistant case of lethal catatonia responded selectively to high-dose olanzapine treatment. The case illustrates the need to consider lethal catatonia in apparent cases of neuroleptic malignant syndrome that do not respond to conventional treatment with dantrolene and bromocriptine.
authors.affiliation: Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin. eucass@hotmail.com
authors.forename: E M
authors.initials: EM
authors.lastname: Cassidy
authors.forename: M
authors.initials: M
authors.lastname: O'Brien
authors.forename: M F
authors.initials: MF
authors.lastname: Osman
authors.forename: J
authors.initials: J
authors.lastname: Finucane
authors.forename: V
authors.initials: V
authors.lastname: O'Keane
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001714:Bipolar Disorder / Q000150:complications; D002389:Catatonia / Q000188:drug therapy*; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D009459:Neuroleptic Malignant Syndrome / Q000188:drug therapy*; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011595:Psychomotor Agitation / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine