title: Miller Fisher syndrome: toward a more comprehensive understanding.
abstract: OBJECTIVE
  To review recent knowledge on the clinical features, pathology and pathophysiology, diagnosis and treatment of Miller Fisher syndrome (MFS).
  
  
  METHODS
  Clinical and laboratory studies on MFS in the past 10 years were included.
  
  
  RESULTS
  A viral infection preceded neurological symptoms in 71.8% of MFS patients. Typical MFS consists of the triad of ataxia, areflexia and ophthalmoplegia. Other cranial nerves are also involved, which may overlap with limb weakness in typical Guillain-Barre syndrome (GBS). Lower cranial nerve variants of GBS, atypical MFS and ataxic neuropathies may overlap, and are thought of as variant forms of MFS. Recurrence and CNS involvement is found more frequently in MFS than in GBS. Antibody to GQ1b, a tetrasyaloganglioside (GQ1b antibody) which is found in close relation to ophthalmoplegia in MFS, is also associated with Campylobacter jejuni (C. jejuni) serotype Penner 2. This suggests that C. jejuni may induce MFS via the GQ1b structure. The GQ1b antibody may lead to the failure of acetylcholine release from motor nerve terminals, which has been confirmed by clinical neurophysiological results.
  
  
  CONCLUSIONS
  Many studies have shown similarities in the pathogenesis of MFS and GBS. However, there are still some differences between them, especially in the areas of sensory and CNS involvement. The GQ1b antibody is thought of as one of the key factors in the pathogenesis of MFS, especially with ophthalmoplegia, and it may prove a useful clinical marker in the diagnosis of MFS.
authors.affiliation: Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China. drlhf@public.qd.sd.cn
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Yuan
mesh_terms: D002490:Central Nervous System / Q000503:physiopathology; D004594:Electrophysiology; D006801:Humans; D019846:Miller Fisher Syndrome / Q000473:pathology* / Q000503:physiopathology*