[Clinical analysis of 935 cases of non-Hodgkin's lymphoma].
OBJECTIVE
To analyze the results of treatment of non-Hodgkin's lymphoma (NHL).


METHODS
The results of treatment in 935 NHL patients were reviewed according to life table Log rank analysis.


RESULTS
Patients with moderately malignant NHL had better long-term survival, as compared with other pathologic types (P < 0.05). Patients in clinical stage I had better prognosis than those in stage II, III and IV (P < 0.001). Patients achieved CR as short-term response had the best prognosis. When analyzed according to treatment modalities, the long-term effect was seemingly better in patients treated with chemotherapy + radiotherapy than in patients treated with radiotherapy alone or chemotherapy alone, but the different was statistically insignificant. If the results are compared between patients treated in 1983 through 1988 and those in 1989 through 1993, there was marked improvement in long-term survival in the latter time period during which patients were given more intensive chemotherapy.


CONCLUSIONS
The long-term survival rate of patients with NHL was closely related to pathologic types, clinical stage, short-term therapeutic effect. Intensive chemotherapy help improve prognosis. The leaping manner of NHL dissemination requires sufficient systematic therapy.
Wang
Q
Q
Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021.
Zhou
L
L
He
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015996:Survival Rate