[Changes of plasma levels of type C natriuretic peptide in patients with pregnancy induced hypertension].
OBJECTIVE
To investigate the changes and clinical significance of plasma type C natriuretic peptide (CNP) concentration in patients with pregnancy induced hypertension (PIH).


METHODS
Plasma CNP levels were detected by radioimmunoassay in 89 patients with PIH, 193 normal pregnant women and 46 normal non-pregnant women. Outcomes were statistically analyzed by one-way analysis of variance and Student-Nawman-Kenls (SNK) test.


RESULTS
The plasma CNP levels in patients with PIH [(30.51 +/- 33.61) ng/L] were significantly higher than those of normal non-pregnant women and normal pregnancies [(17.15 +/- 3.82) ng/L, (19.43 +/- 5.13) ng/L, respectively; F = 13.61, P < 0.01]. There was significant difference among plasma CNP levels from patients with mild, moderate, and severe PIH (P < 0.0001).


CONCLUSIONS
The changes of plasma CNP levels are believed to be the reflection of patients in progression of PIH and can be used as a biochemical marker for judging the progression and guiding the therapy of PIH.
Gao
Z
Z
Department of Obstrics and Gynecology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Zhang
Y
Y
Li
Z
Z
D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D020098:Natriuretic Peptide, C-Type / Q000097:blood*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D011863:Radioimmunoassay
D020098:Natriuretic Peptide, C-Type