title: Evaluation of thrombogenicity of fluoropassivated polyester patches following carotid endarterectomy.
abstract: The use of a patch after carotid endarterectomy (CE) is recommended to reduce the incidence of restenosis. Most studies on this subject report the implantation of saphenous vein or PTFE patches, because polyester has always been considered to be a thrombogenic material. The purpose of this study was to evaluate the thrombogenicity of a knitted polyester patch passivated by fluoropolymer surface treatment (FPD patch), which experimental studies have demonstrated to be less thrombogenic than other materials. This prospective, randomized study was performed in 22 patients who underwent CE. In 11 patients the arteriotomy was sutured directly, while in the other 11 an FPD patch was applied. Patients' 111in-oxine labeled platelets were reinjected on the first postoperative day, and scintigraphies were performed after 4, 24, and 48 hr, respectively. The study confirmed that an FPD patch is no more thrombogenic than a simple carotid endarterectomy. The application of the patch, therefore, can be recommended to reduce restenosis without any adjunctive thromboembolic risk.
authors.affiliation: Vascular Surgery Unit, Department of Surgery, Ospedale Maggiore CA Pizzardi, Largo B Nigrisoli, 2, 40133 Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pedrini
authors.forename: M
authors.initials: M
authors.lastname: Dondi
authors.forename: A
authors.initials: A
authors.lastname: Magagnoli
authors.forename: F
authors.initials: F
authors.lastname: Magnoni
authors.forename: E
authors.initials: E
authors.lastname: Pisano
authors.forename: E
authors.initials: E
authors.lastname: Del Giudice
authors.forename: M
authors.initials: M
authors.lastname: Santoro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001780:Blood Coagulation Tests; D002341:Carotid Artery Thrombosis / Q000097:blood / Q000188:drug therapy* / Q000601:surgery*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000601:surgery; D020099:Coated Materials, Biocompatible / Q000009:adverse effects; D003131:Combined Modality Therapy; D016894:Endarterectomy, Carotid; D006801:Humans; D008297:Male; D008875:Middle Aged; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011091:Polyesters / Q000009:adverse effects* / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D012307:Risk Factors; D013223:Statistics as Topic; D013525:Surgical Instruments; D013536:Suture Techniques; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D020099:Coated Materials, Biocompatible; D011091:Polyesters