Evidence of a normal mean telomere fragment length in patients with Ullrich-Turner syndrome.
Clinical and epidemiological studies suggest that premature ageing and increased morbidity and mortality is present in Ullrich-Turner syndrome. We studied telomere restriction fragment length (TRFL) in 30 women with Ullrich-Turner syndrome and 30 age-matched control women. All Turner women had the 45,X karyotype verified by karyotyping. We found no difference in the mean TRFL in the young age group (TS: 7011+/-521 vs C: 7285+/-917 bp, P = 0.3), or in the older age group (TS: 7357+/-573 vs C: 7221+/-621 bp, P = 0.6). In conclusion, our data suggest that Ullrich-Turner syndrome is not associated with excessive telomere loss, at least when studied in peripheral blood leucocytes, and thus quite different from other premature ageing syndromes.
Kveiborg
M
M
Danish Centre of Molecular Gerontology, Arhus University Hospital, DK-8000 Arhus C, Denmark.
Gravholt
C H
CH
Kassem
M
M
D000328:Adult; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D016615:Telomere / Q000235:genetics*; D014424:Turner Syndrome / Q000235:genetics*
D004247:DNA