[Treatment of bacterial peritonitis with dachengqi decoction and rhubarb in mice].
OBJECTIVE
To observe the antiseptic effect of Dachengqi Decoction (DCQD) or rhubarb, one of the ingredients of DCQD in mice.


METHODS
The model mice were established by peritoneal injection of Escherichia coli (10(8)/ml) or Proteus vulgaris (10(6)/ml) respectively. DCQD or rhubarb was given from 2 days before to 2 days after modelling for preventing and treating.


RESULTS
The mortality and bacteremia occurrence of the treatment group were significantly lower than those of the control group (P < 0.05). Both DCQD and rhubarb showed protective effect on Escherichia. coli or Proteus vulgaris infection in mice. The cardiac blood smear and culture of survival mice in prevention plus treatment group and model group showed negative (bacteria) results but those of dead mice showed positive result.


CONCLUSIONS
DCQD and rhubarb have excellent bactericidal effect.
Hu
P
P
Department of Pharmacology, Tianjin Medical University, Tianjin (300070).
Bai
F
F
Li
D
D
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D008297:Male; D051379:Mice; D010538:Peritonitis / Q000188:drug therapy* / Q000382:microbiology; D011511:Proteus / Q000187:drug effects; D011512:Proteus Infections / Q000188:drug therapy / Q000382:microbiology; D011897:Random Allocation; D012250:Rheum
D004365:Drugs, Chinese Herbal