Concurrent left-sided spontaneous pneumothorax in Japanese monogerminal twins.
Monogerminal twin brothers aged 17 were admitted because of concurrent left-sided spontaneous pneumothorax. A familial background of this common disease in association with the human leukocyte antigen (HLA) has been suggested; however, the actual mode of inheritance in association with HLA typing is still uncertain. HLA analysis in this family revealed the HLA-A24, B61 (40), Cw3, DR4, DR53, and DQ3 haplotype in the twins and their father, who also had a medical history of spontaneous pneumothorax. We report these cases as an extremely rare example of familial occurrence of spontaneous pneumothorax.
Tsukadaira
A
A
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Okubo
Y
Y
Ota
M
M
Hotta
J
J
Kubo
K
K
D000293:Adolescent; D004200:Diseases in Twins / Q000235:genetics*; D006680:HLA Antigens / Q000032:analysis*; D006239:Haplotypes; D006801:Humans; D008297:Male; D011030:Pneumothorax / Q000235:genetics* / Q000276:immunology; D014430:Twins, Monozygotic
D006680:HLA Antigens