title: Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms.
abstract: We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.
authors.affiliation: Division of Functional Genomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Momose
authors.forename: Miho
authors.initials: M
authors.lastname: Murata
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Masaji
authors.initials: M
authors.lastname: Tachikawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakabayashi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kanazawa
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Toda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004298:Dopamine / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013869:Thiolester Hydrolases / Q000235:genetics; D043222:Ubiquitin Thiolesterase
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D003577:Cytochrome P-450 Enzyme System; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; D004298:Dopamine