[Helicobacter pylori infection and expression of PCNA, p53, c-erbB-2 in carcinoma and precancerours lesions of the stomach].
OBJECTIVE
To study the role of Helicobacter pylori (Hp) in gastric carcinoma.


METHODS
Hp was examined in 70 patients with gastric carcinoma, 62 patients with pre-malignant lesions and 16 controls by improved Warthin-Starry method and PCNA, p53, cerbB-2 protein examined immunohistochemically.


RESULTS
The frequency of Hp infection in gastric carcinoma and its precusor lesions was significantly higher than that in the controls. There was no significant difference in Hp infection rate between gastric carcinoma and its precursor lesions, nor between the intestinal type and diffuse type of gastric carcinoma. Hp infection correlated well with expressions of PCNA, c-erbB-2 and with co-expression of PCNA, p53 and c-erbB-2 in gastric carcinoma and its precusors. p53 protein was expressed only in gastric carcinoma, and its expression level was higher in the presence than in the absence of Hp infection (P < 0.01).


CONCLUSIONS
Hp might act as a tumor promoter in the genesis of gastric cancer.
Lu
W
W
Depatement of Pathology, Fujian Medical University, Fuzhou 350004.
Chen
L
L
Gong
H
H
D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D011230:Precancerous Conditions / Q000209:etiology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D013274:Stomach Neoplasms / Q000209:etiology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D018809:Proliferating Cell Nuclear Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53