title: Visual disorders associated with omeprazole and their relation to CYP2C19 polymorphism.
abstract: Risk factors for patients developing visual disturbances in association with proton pump inhibitors are unknown. As omeprazole is substantially metabolized by polymorphic CYP2C19, we retrospectively identified and genotyped patients who experienced this adverse reaction. Among 29 patients, we found two poor metabolizers (PMs) of CYP2C19. The PM genotype does not appear to be a risk factor for omeprazole-associated visual disorders.
authors.affiliation: Division of Clinical Pharmacology, University Hospital Tübingen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Lutz
authors.forename: Matthias
authors.initials: M
authors.lastname: Schwab
authors.forename: Ernst-Ulrich
authors.initials: EU
authors.lastname: Griese
authors.forename: Claudia
authors.initials: C
authors.lastname: Marx
authors.forename: Bruno
authors.initials: B
authors.lastname: Müller-Oerlinghausen
authors.forename: Peter S
authors.initials: PS
authors.lastname: Schönhöfer
authors.forename: Christoph
authors.initials: C
authors.lastname: Meisner
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Gleiter
authors.forename: Michel
authors.initials: M
authors.lastname: Eichelbaum
authors.forename: Klaus
authors.initials: K
authors.lastname: Mörike
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D001189:Aryl Hydrocarbon Hydroxylases; D065731:Cytochrome P-450 CYP2C19; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004791:Enzyme Inhibitors / Q000009:adverse effects*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000235:genetics*; D009853:Omeprazole / Q000009:adverse effects*; D010641:Phenotype; D011110:Polymorphism, Genetic; D054328:Proton Pump Inhibitors; D012189:Retrospective Studies; D014786:Vision Disorders / Q000139:chemically induced* / Q000201:enzymology / Q000235:genetics*
chemical_list: D000897:Anti-Ulcer Agents; D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D009853:Omeprazole