In vitro response of macrophages to a new carbon-polylactide composite for the treatment of periodontal diseases.
The purpose of the study was to examine the response of macrophages and the concentration of selected released cytokines following contact with a new carbon-polylactide composite. The macrophages were grown on samples of the materials and on each of its components separately. Viability of the cells as well as concentrations of interleukins IL-6, IL-10, IL-12 and TNF-alpha were then determined. Some differences in the viability of the cells were demonstrated. They varied according to the kind of material used. After incubation with the serum, the composite and its components induced the release of IL-6, IL-12 and TNF-alpha which did not differ significantly from one another.
Chomyszyn-Gajewska
Maria
M
Department of Conservation Dentistry, Jagiellonian University, Collegium Medicum, Cracow, Poland. mdgajews@cyf-kr.edu.pl
Czajkowska
Barbara
B
Blazewicz
Marta
M
Pamula
Elzbieta
E
Ptak
Maria
M
D000818:Animals; D001672:Biocompatible Materials; D017554:Carbon Compounds, Inorganic; D002460:Cell Line; D066298:In Vitro Techniques; D007378:Interleukins / Q000378:metabolism; D019344:Lactic Acid; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010510:Periodontal Diseases / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D011108:Polymers; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D001672:Biocompatible Materials; D017554:Carbon Compounds, Inorganic; D007378:Interleukins; D011108:Polymers; D014409:Tumor Necrosis Factor-alpha; C031979:carbon-polylactic acid polymer; D019344:Lactic Acid