title: [Effect of growth hormone on the outcome of ovulation induction in patients with polycystic ovary syndrome].
abstract: OBJECTIVE
  To study the effect of growth hormone (GH) on the outcome of ovulation induction in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  We examined serum sex hormone, GH and insulin like growth factor-II (IGF-II) basal levels by radioimmunoassay in 130 PCOS patients and 107 normal women. In addition, we observed the effect of GH on the outcome of ovulation induction in 7 poor responders to human menopausal gonadotropin (hMG) treatment.
  
  
  RESULTS
  The mean serum GH level is (2.50 +/- 1.33) micrograms/L and (1.04 +/- 0.47) micrograms/L respectively in nonobese and obese PCOS patients which were significantly lower than those in controls [(5.30 +/- 2.26) micrograms/L, (2.95 +/- 1.49) micrograms/L respectively, P < 0.05]. The mean serum IGF-II level is (136 +/- 27) nmol/L in the obese PCOS patients, significantly greater than those in nonobese PCOS and controls (P < 0.05). When we used GH with hMG in 7 poor responders, the total amount of hMG required decreased from 1 to 12 amples and the duration of treatment shortened as compared with hMG alone.
  
  
  CONCLUSIONS
  There is abnormal GH secretion in patients with PCOS, GH may improve the outcome of ovulation induction by gonadotropin.
authors.affiliation: Department of Obstetric and Gynecology, Third Hospital, Peking University, Beijing 100083, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Yang
mesh_terms: D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*
chemical_list: D013006:Growth Hormone