Neonatal alloimmune thrombocytopenia due to anti-human leukocyte antigen antibody: a case report.
Anti-HLA antibodies reportedly exist in 31% of pregnant women. However, few ocurrences of neonatal alloimmune thrombocytopenia (NAIT) caused by anti-HLA antibody have been reported. In this study, maternal anti-HLA B60 and B61 antibodies were identified in patient serum at birth, but no anti-platelet antibodies were present. No maternal anti-HLA A2, A24, B51, or B52 antibodies were detected in patient serum. Platelet transfusion from the third donor was effective because these platelets expressed HLA A24 and B52 but not B60 or B61. Cross-matching tests between patient leukocytes or platelets and maternal serum were strongly positive, indicating that maternal anti-HLA antibodies were responsible for NAIT. This report is the first to demonstrate NAIT probably caused by maternal anti-HLA A24 and B52.
Sasaki
M
M
Department of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Japan.
Yagihashi
A
A
Kobayashi
D
D
Watanabe
N
N
Fujikawa
T
T
Chiba
S
S
Sato
S
S
Morishita
K
K
Sekimoto
T
T
Ikeda
H
H
D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D015234:HLA-A Antigens / Q000276:immunology; D059871:HLA-A24 Antigen; D015235:HLA-B Antigens / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008431:Maternal-Fetal Exchange / Q000276:immunology; D017713:Platelet Transfusion; D011247:Pregnancy; D013921:Thrombocytopenia / Q000151:congenital / Q000276:immunology* / Q000628:therapy
D006680:HLA Antigens; D015234:HLA-A Antigens; D059871:HLA-A24 Antigen; D015235:HLA-B Antigens; C081918:HLA-B60 antigen; D007518:Isoantibodies