title: Acute and chronic toxicity of fessoukh, the resinous gum of Ferula communis L, compared to warfarin.
abstract: The acute toxicity of the fessoukh extract (FE) was studied in rats and mice. In single oral dose administration mode, FE has moderate toxicity; the LD50s were 1650 mg/kg bw in rats and 2000 mg/kg bw in mice. In albino rats, with baits containing 0.01 to 10% FE, 0.01% produced 100% mortality in 15 d; with 0.1%, all rats died in 9 d. Baits containing 0.1% were toxic, more consumed, required less product and did not cause apprehension in the rats. A trial conducted with wild rats (Rattus norvegicus) using 0.1% FE baits demonstrated fessoukh's rodenticide effects.
authors.affiliation: Département de Pharmacognosie, Faculté de Médecine et de Pharmacie, Rabat-Instituts, Maroc.
authors.forename: O
authors.initials: O
authors.lastname: Fraigui
authors.forename: D
authors.initials: D
authors.lastname: Lamnaouer
authors.forename: M Y
authors.initials: MY
authors.lastname: Faouzi
authors.forename: Y
authors.initials: Y
authors.lastname: Cherrah
authors.forename: M
authors.initials: M
authors.lastname: Tijjane
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000925:Anticoagulants / Q000633:toxicity*; D005260:Female; D005309:Ferula / Q000737:chemistry*; D008297:Male; D051379:Mice; D018514:Plant Structures / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012116:Resins, Plant / Q000633:toxicity; D014859:Warfarin / Q000633:toxicity*
chemical_list: D000925:Anticoagulants; D012116:Resins, Plant; D014859:Warfarin