[Effect of shenshuaining on proliferation and autocrine interleukin-1 secretion of human mesangial cells].
OBJECTIVE
To explore the effect of Shenshuaining (SSN), on the proliferation of human mesangial cells (HMC) and the autocrine secretion of interleukin-1 (IL-1).


METHODS
SSN, a preparation of Chinese herbal drug having actions of Qi supplementing, origin consolidation, blood stasis resolving and turbid substance removing, medicated serum of animal was extracted by pharmacologic method and its effect on proliferation and autocrine IL-1 secretion of HMC was observed.


RESULTS
SSN could inhibit the proliferation and IL-1 autocrine secretion of HMC, and the inhibition was dose-dependent.


CONCLUSIONS
Mesangial cell is the important target cell for action of SSN, the inhibition on HMC may be one of the mechanisms of SSN in prevention and treatment of chronic renal failure.
Liu
T
T
Beijing University of Traditional Chinese Medicine and Pharmacology, Beijing (100029).
Ye
C
C
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005920:Glomerular Mesangium / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D007375:Interleukin-1