[Structural and functional changes in sympathetic ganglia following endotoxin and alpha1-antitrypsin exposure].
Structural and functional organisation of sympathetic ganglia under conditions of endotoxemia was studied in white rats, cats, and dogs. Submicroscopic characteristics of the changes occurring in the rat prevertebral sympathetic ganglia after endotoxin administration or application of endogenous proteinase inhibitor alpha 1-antitrypsin, were assessed as well as ultrastructural bases of the febrile rat ganglionic responses to antipyretic drug administration. Effects of endotoxin on synaptic transmission in inferior mesenteric plexus' ganglia of cats and on electrical activity in inferior mesenteric plexus' ganglia of dogs, were electrophysiologically demonstrated.
Archakova
L I
LI
Institute of Physiology, National Acad. Sci., Minsk, 220072, Akademicheskaya St., 28, Belarus.
Gurin
A V
AV
Denisenko
N P
NP
Novakovskaia
S A
SA
Rubakhova
V M
VM
Sandakov
D B
DB
D000200:Action Potentials; D000344:Afferent Pathways; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001427:Bacterial Toxins / Q000494:pharmacology*; D001833:Body Temperature Regulation; D002415:Cats; D004285:Dogs; D004525:Efferent Pathways; D004731:Endotoxins / Q000494:pharmacology*; D005334:Fever / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D005728:Ganglia, Sympathetic / Q000187:drug effects* / Q000648:ultrastructure*; D066298:In Vitro Techniques; D008070:Lipopolysaccharides; D008854:Microscopy, Electron; D011749:Pyrogens; D051381:Rats; D012980:Sodium Salicylate / Q000494:pharmacology; D009435:Synaptic Transmission; D000515:alpha 1-Antitrypsin / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001427:Bacterial Toxins; D004731:Endotoxins; D008070:Lipopolysaccharides; D011749:Pyrogens; D000515:alpha 1-Antitrypsin; C009136:pyrogenal; C027952:salmonella toxin; D012980:Sodium Salicylate
Strukturno-funktsional'nye izmeneniia v simpaticheskikh gangliiakh pri deĭstvii v organizme éndotoksina i al'fa-antitripsina.