Effects of N-nitropyrazoles on ocular blood flow of rabbits and retinal function recovery of rat eyes after ischemic insults.
Twelve compounds of N-nitropyrazoles were studied for their effects on ocular blood flow in rabbits and retinal function recovery in rat eyes after ischemic insults. Of the twelve N-nitropyrazoles examined, nine increased choroidal blood flow while five increased retinal blood flow significantly. On the other hand, all twelve compounds increased blood flow in iris and ciliary muscle without exception. As for retinal function recovery after ischemic insult in rat eyes, eight out of the twelve compounds showed more significant facilitation than the control. The structure activity relationship of the N-nitropyrazoles to increase ocular blood flow and to facilitate retinal function recovery after ischemic insults were discussed.
Xuan
B
B
Institute of Ocular Pharmacology, and Department of Medical Pharmacology and Toxicology, Texas A&M University System Health Science Center, College Station 77843-1114, USA.
Wang
T
T
Chiou
G C
GC
Dalinger
I
I
Shkineva
T K
TK
Shevelev
S A
SA
D000818:Animals; D002829:Choroid / Q000098:blood supply / Q000187:drug effects; D019842:Ciliary Arteries / Q000187:drug effects; D005260:Female; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D020318:Rats, Long-Evans; D012039:Regional Blood Flow / Q000187:drug effects; D012160:Retina / Q000187:drug effects* / Q000502:physiology; D012171:Retinal Vessels / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013997:Time Factors
D011720:Pyrazoles