title: Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat.
abstract: The effects of pinealectomy and exogenous melatonin (N-acetyl-5-methoxytryptamine) on serum leptin levels were investigated in rats. Exogenous administration of melatonin to intact rats resulted in significant decreases in serum leptin levels (P < 0.05) compared to those of the intact control group. Serum leptin levels were significantly elevated in the pinealectomised rats in comparison to the sham-pinealectomised animals (P < 0.001) and were significantly suppressed by exogenous administration of melatonin compared to those of non-treated pinealectomised rats (P < 0.001). Hormone concentrations in the melatonin-treated pinealectomised group were found to be similar to those seen in the sham-pinealectomised group. These results suggest that pineal gland has an effect on leptin release.
authors.affiliation: Department of Physiology, Medical School, Firat University, Elazig, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Canpolat
authors.forename: S
authors.initials: S
authors.lastname: Sandal
authors.forename: B
authors.initials: B
authors.lastname: Yilmaz
authors.forename: A
authors.initials: A
authors.lastname: Yasar
authors.forename: S
authors.initials: S
authors.lastname: Kutlu
authors.forename: G
authors.initials: G
authors.lastname: Baydas
authors.forename: H
authors.initials: H
authors.lastname: Kelestimur
mesh_terms: D000818:Animals; D020738:Leptin / Q000097:blood*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D020738:Leptin; D008550:Melatonin