title: [New therapeutic prospects in microcytoma].
abstract: The therapeutic efforts of the past thirty years have been directed at improving the scant prognosis of patients suffering from microcytoma (SCLC) using a combination of chemotherapy and radiotherapy. Studies have shown that the longest survival rates are achieved when radiotherapy is administered concomitantly with chemotherapy. No clear correlation has been identified between the 3-year disease-free survival rate and the type of chemotherapy used. The standard treatment for patients suffering from SCLC is currently polychemotherapy using protocols with cisplatin, with or without radiotherapy. Among the new protocols that have been proposed, an increase in dose intensity, weekly therapy and alternating chemotherapy appear to give the most promising results, even if no studies have so far actually demonstrated their ability to improve results.
authors.affiliation: Oncologia Medica, Istituto Oncologico, Bari, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Lorusso
authors.forename: E
authors.initials: E
authors.lastname: Crucitta
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Nuove prospettive terapeutiche nel microcitoma. Inquadramento clinico e chemioterapia.