Use of a GnRH analogue implant to produce reversible long-term suppression of reproductive function in male and female domestic dogs.
Continuous low-dose administration of a GnRH analogue postpones oestrus in bitches and suppresses reproductive function in dogs. A new drug delivery formulation that could enhance the practicality of this approach for the control of reproduction has been developed. The objective of the present study was to determine whether this method of delivery could, by sustained release of the GnRH analogue deslorelin, act as a reversible anti-fertility agent in domestic male and female dogs for periods exceeding 1 year. Several long-term studies were performed, which monitored reproductive function in 30 dogs and 52 bitches. Suppression of reproductive function in male dogs was dose-related. Spermatogenesis was suppressed for more than a year in 14 of 16 dogs that received doses of > 0.25 mg deslorelin kg-1. In females, postponement of oestrus for periods of up to 27 months was observed, but there was no relationship between the stage of the oestrous cycle at the start of treatment and the duration of efficacy. Treatment-induced effects on fertility were reversible in both sexes. In summary, sustained release deslorelin implants were shown to elicit reversible long-term reproductive control in male and female domestic dogs.
Trigg
T E
TE
Peptech Animal Health, 35-41 Waterloo Road, North Ryde 2113, Australia.
Wright
P J
PJ
Armour
A F
AF
Williamson
P E
PE
Junaidi
A
A
Martin
G B
GB
Doyle
A G
AG
Walsh
J
J
D000818:Animals; D003267:Contraception / Q000662:veterinary*; D003270:Contraceptive Agents / Q000008:administration & dosage*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage; D003272:Contraceptive Agents, Male / Q000008:administration & dosage; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D004971:Estrus / Q000187:drug effects; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D008297:Male; D013091:Spermatogenesis / Q000187:drug effects; D017329:Triptorelin Pamoate / Q000031:analogs & derivatives
D003270:Contraceptive Agents; D003271:Contraceptive Agents, Female; D003272:Contraceptive Agents, Male; D004343:Drug Implants; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C066438:deslorelin