IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset.
Myasthenia gravis (MG) is a multifactorial autoimmune disease of the neuromuscular junction. We investigated the relation between four polymorphisms of the interleukin (IL)-1 gene cluster on 2q12-22, and MG susceptibility and clinical features in a large cohort of individuals. No polymorphism was associated with MG susceptibility. However, the IL-1A -889 CC genotype was associated with early disease onset (p=0.0044) in the whole MG group and the subgroup of CC males developed MG about 18 years earlier than males carrying other IL-1A -889 genotypes (p=0.022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2.
Sciacca
Francesca L
FL
Neuromuscular Disease Department, National Neurological Institute, C. Besta, Milan, Italy.
Ferri
Cinzia
C
Veglia
Fabrizio
F
Andreetta
Francesca
F
Mantegazza
Renato
R
Cornelio
Ferdinando
F
Franciotta
Diego
D
Piccolo
Giovanni
G
Cosi
Vittorio
V
Batocchi
Anna P
AP
Evoli
Amelia
A
Grimaldi
Luigi M E
LM
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors
D007375:Interleukin-1