Stress-modulated growth, residual stress, and vascular heterogeneity.
A simple phenomenological model is used to study interrelations between material properties, growth-induced residual stresses, and opening angles in arteries. The artery is assumed to be a thick-walled tube composed of an orthotropic pseudoelastic material. In addition, the normal mature vessel is assumed to have uniform circumferential wall stress, which is achieved here via a mechanical growth law. Residual stresses are computed for three configurations: the unloaded intact artery, the artery after a single transmural cut, and the inner and outer rings of the artery created by combined radial and circumferential cuts. The results show that the magnitudes of the opening angles depend strongly on the heterogeneity of the material properties of the vessel wall and that multiple radial and circumferential cuts may be needed to relieve all residual stress. In addition, comparing computed opening angles with published experimental data for the bovine carotid artery suggests that the material properties change continuously across the vessel wall and that stress, not strain, correlates well with growth in arteries.
Taber
L A
LA
Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA. lat@biomed.wustl.edu
Humphrey
J D
JD
D000818:Animals; D001011:Aorta / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology; D001158:Arteries / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology*; D003198:Computer Simulation; D004548:Elasticity; D020342:Finite Element Analysis; D008955:Models, Cardiovascular; D051381:Rats; D013314:Stress, Mechanical