Molecular mechanism of cholinergic dysfunction and cognitive deficits induced by amyloid beta-peptide.
Amyloid beta-peptide (A beta) plays a critical role in the development of Alzheimer's disease (AD). Much progress has been made in understanding this age-related neurodegenerative disorder; thus an insight into the cellular actions of A beta and resulting functional consequences may contribute to preventive and therapeutic approaches for AD. In this review, recent evidence of A beta-induced brain dysfunction, especially cholinergic impairment and memory deficits, is summarized. Moreover, proposed mechanisms for A beta-induced neurotoxicity such as oxidative stress, ion-channel formation, and A beta-receptor interaction are discussed.
Tran
M H
MH
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8560 Japan.
Yamada
K
K
Nabeshima
T
T
D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced*; D002795:Choline O-Acetyltransferase / Q000037:antagonists & inhibitors; D003072:Cognition Disorders / Q000139:chemically induced*; D006801:Humans; D011950:Receptors, Cholinergic / Q000187:drug effects
D016229:Amyloid beta-Peptides; D011950:Receptors, Cholinergic; D002795:Choline O-Acetyltransferase