title: Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's disease.
abstract: We have previously reported a significant association between early-onset Alzheimer's disease (EOAD) and an allele in the promoter of presenilin 1 (PSEN1) significantly decreasing PSEN1 expression in vitro. For late-onset Alzheimer's disease (LOAD), numerous studies have reported inconsistent associations with a PSEN1 intronic polymorphism. We therefore hypothesized that linkage disequilibrium between the intronic PSEN1 polymorphism and the functional promoter polymorphism might explain the conflicting reports in LOAD. We analysed both variations in 356 LOAD patients and 230 controls in a population-based case-control study. In addition, we re-analysed all published literature on the PSEN1 intronic polymorphism in a meta-analysis. No significant association was found with the PSEN1 intronic or promoter polymorphism in our case-control sample. In the meta-analysis no major differences between patients and controls were found for the PSEN1 intronic variation. Together, our results do not support a major role for variable expression of PSEN1 in LOAD.
authors.affiliation: University of Antwerp, Department of Biochemistry. Universiteitsplein 1, Antwerpen, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Dermaut
authors.forename: G
authors.initials: G
authors.lastname: Roks
authors.forename: J
authors.initials: J
authors.lastname: Theuns
authors.forename: R
authors.initials: R
authors.lastname: Rademakers
authors.forename: J J
authors.initials: JJ
authors.lastname: Houwing-Duistermaat
authors.forename: S
authors.initials: S
authors.lastname: Serneels
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: M M
authors.initials: MM
authors.lastname: Breteler
authors.forename: M
authors.initials: M
authors.lastname: Cruts
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: C M
authors.initials: CM
authors.lastname: van Duijn
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000032:analysis / Q000096:biosynthesis*; D011110:Polymorphism, Genetic; D053764:Presenilin-1; D012307:Risk Factors
chemical_list: D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1