[The anti-atherogenic mechanism of action of physical training in patients with coronary heart disease].
In randomized trials, moderate to aggressive lipid-lowering therapy as well as regular physical exercise have both been shown to restore endothelial function, slow progression and in some patients even lead to regression of coronary artery disease. Furthermore, a reduced rate of cardiac events, morbidity and mortality have been documented. Similarly, regular physical exercise training has been identified to contribute independently to beneficial changes in the risk factor profile, retardation of the progression of coronary lesions and has been associated with a reduced rate of mortality. Therefore, besides adhering to a low fat diet, patients with coronary artery disease should further be motivated to include physical exercise in their daily routine. Although it has been puzzling how exercise training exerts antiatherogenic effects, accumulating evidence has recently unraveled some of the underlying cellular and molecular pathomechanisms, which will be discussed in this review.
Niebauer
J
J
Herzzentrum der Universität Leipzig Innere Medizin/Kardiologie Russenstr. 19 04289 Leipzig, Germany. j.niebauer@medizin.uni-leipzig.de
Schuler
G
G
D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000534:rehabilitation*; D004730:Endothelium, Vascular / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage; D009569:Nitric Oxide / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D010806:Physical Education and Training; D016032:Randomized Controlled Trials as Topic
D000960:Hypolipidemic Agents; D009569:Nitric Oxide
Antiatherogene Wirkungsmechanismen des körperlichen Trainings bei Patienten mit koronarer Herzkrankheit.