title: Bacteroides ovatus as the predominant commensal intestinal microbe causing a systemic antibody response in inflammatory bowel disease.
abstract: To clarify what bacterial species of commensal intestinal microbes are recognized as the antigens that induce a serum antibody response in patients with inflammatory bowel disease (IBD), 72 subjects consisting of 12 Crohn's disease patients, 30 ulcerative colitis patients, and 30 healthy volunteers were examined for their titers of serum antibody to these intestinal bacteria. In IBD patients, as a result, significant elevations of both the immunoglobulin G (IgG) and IgA titers to Bacteroides ovatus were found. Immunoblotting showed that a definite 19.5-kDa band of B. ovatus was bound to the serum antibody raised in IBD patients. It was thus concluded that B. ovatus causes serum antibody responses in IBD patients, and a 19.5-kDa molecule of this bacterium appears to be the responsible antigen, although the role of this event in pathogenesis remains unclear.
authors.affiliation: Departments of Infectious Diseases. Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Saitoh
authors.forename: Satoshi
authors.initials: S
authors.lastname: Noda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Aiba
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takagi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Benno
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Koga
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology; D001439:Bacteroides / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000382:microbiology*; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial