Safety and efficacy of an improved antiseptic catheter impregnated intraluminally with chlorhexidine.
The safety and efficacy of a second-generation improved antiseptic catheter impregnated with silver sulfadiazine and increased levels of chlorhexidine on its outer surface and chlorhexidine alone on its luminal surfaces was compared in vitro and in vivo to standard antiseptic catheters impregnated with these antimicrobials on their outer surfaces only. In rat and pig intravenous models, the improved antiseptic catheter was significantly more effective in resisting both outer surface and luminal colonization compared with the standard antiseptic or control catheters. There was no evidence of tissue toxicity in any group.
Sampath
L A
LA
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, USA.
Saborio
D V
DV
Yaron
I
I
Modak
S
S
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000009:adverse effects / Q000097:blood / Q000592:standards*; D002408:Catheters, Indwelling / Q000009:adverse effects / Q000382:microbiology* / Q000592:standards*; D002710:Chlorhexidine / Q000009:adverse effects / Q000097:blood / Q000592:standards*; D020099:Coated Materials, Biocompatible / Q000009:adverse effects / Q000592:standards*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016903:Drug Monitoring; D004866:Equipment Contamination / Q000517:prevention & control*; D006801:Humans; D017053:Infection Control / Q000295:instrumentation / Q000379:methods; D008422:Materials Testing; D051381:Rats; D017207:Rats, Sprague-Dawley; D012449:Safety; D013552:Swine
D000891:Anti-Infective Agents, Local; D020099:Coated Materials, Biocompatible; D002710:Chlorhexidine