title: The dose-related effects of bolus esmolol on heart rate and blood pressure following laryngoscopy and intubation.
abstract: Many researchers have studied esmolol and its effects on heart rate and blood pressure. All studied relatively large doses of esmolol. Therefore, the purpose of the present study was to determine whether small doses of esmolol would blunt the transient increases in blood pressure and heart rate caused by laryngoscopy. This double-blind, prospective, randomized study included 61 subjects. The subjects were randomized to 1 of 3 groups: group 1 received esmolol, 0.2 mg/kg; group 2 received esmolol, 0.4 mg/kg; and group 3 received saline placebo. Groups 1 and 2 had smaller increases in heart rate than group 3. We also found that the 0.4 mg/kg dose significantly blunted the increase in mean arterial pressure seen in group 3. This study shows that small doses of esmolol may block the increases in heart rate and blood pressure resulting from laryngoscopy and intubation.
authors.affiliation: Presbyterian Hospital, Charlotte, NC, USA.
authors.forename: K P
authors.initials: KP
authors.lastname: Bensky
authors.forename: L
authors.initials: L
authors.lastname: Donahue-Spencer
authors.forename: G E
authors.initials: GE
authors.lastname: Hertz
authors.forename: M T
authors.initials: MT
authors.lastname: Anderson
authors.forename: R
authors.initials: R
authors.lastname: James
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D016903:Drug Monitoring; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology*; D007275:Injections, Intravenous; D007430:Intraoperative Care / Q000379:methods; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007828:Laryngoscopy / Q000009:adverse effects*; D008875:Middle Aged; D011412:Propanolamines / Q000008:administration & dosage* / Q000494:pharmacology*; D011446:Prospective Studies; D013610:Tachycardia / Q000188:drug therapy* / Q000209:etiology*; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C036604:esmolol