title: Treatment of pigs experimentally infected with Mycoplasma hyopneumoniae, Pasteurella multocida, and Actinobacillus pleuropneumoniae with various antibiotics.
abstract: The authors have performed a comparative study of the efficacy of various in-feed medications for the treatment of 5- to 6-week-old specific pathogen-free (SPF) piglets experimentally infected on day 1 with Mycoplasma hyopneumoniae, on day 8 with Pasteurella multocida (serotype A), and on day 15 with Actinobacillus pleuropneumoniae (serotype 2). The treatment started on day 9 and continued for 12 consecutive days, then the piglets were euthanized for examination of macroscopic, histologic, and pathologic lesions and for the presence of mycoplasmas and bacteria in the lungs. Based on the results of clinical observations (respiratory signs, rectal temperature, body weight gain, and feed conversion efficiency), macroscopic and histologic lesions of the lungs, and microbiologic findings, the best results were obtained by treatment of pigs with Econor + chlortetracycline, followed by Tetramutin, Pulmotil, Cyfac, and lincomycin + chlortetracycline.
authors.affiliation: Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest. stipkovits@linux.vmri.hu
authors.forename: L
authors.initials: L
authors.lastname: Stipkovits
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.forename: R
authors.initials: R
authors.lastname: Glavits
authors.forename: L
authors.initials: L
authors.lastname: Fodor
authors.forename: D
authors.initials: D
authors.lastname: Burch
mesh_terms: D000189:Actinobacillus Infections / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D016977:Actinobacillus pleuropneumoniae / Q000187:drug effects / Q000254:growth & development; D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002751:Chlortetracycline / Q000494:pharmacology / Q000627:therapeutic use; D004224:Diterpenes / Q000494:pharmacology / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D009174:Mycoplasma / Q000187:drug effects / Q000254:growth & development; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010326:Pasteurella Infections / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D016979:Pasteurella multocida / Q000187:drug effects / Q000254:growth & development; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; C117845:valnemulin; D002751:Chlortetracycline