[The role of hyperlactatedehydrogenasemia in induction of metabolic disorders in the body].
The effect of intravenous administration of lactate dehydrogenase (5000 E/kg) on some metabolic parameters was investigated. The hyperenzymemia was accompanied by changes of metabolite content (glutamate, 2-oxoglutarate, lactate, dihydroxyacetone phosphate) and enzyme activities (aldolase, lactate dehydrogenase, transaminase) in heart, liver and skeletal muscles. Intravenously administered tritiated lactate dehydrogenase was preferentially found in skeletal muscles, liver, kidneys and some other organs.
Gil'miiarova
F N
FN
Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostic of Samara State Medical University.
Radomskaia
V M
VM
Baisheva
G M
GM
Kretova
I G
IG
Kleĭman
M S
MS
Pervova
Iu V
IuV
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D006019:Glycolysis; D007668:Kidney / Q000201:enzymology / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D009928:Organ Specificity; D010084:Oxidation-Reduction; D011817:Rabbits; D013154:Spleen / Q000201:enzymology / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D007770:L-Lactate Dehydrogenase
Rol' giperlaktatdegidrogenazemii v induktsii metabolicheskikh narusheniĭ v organizme.