Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes.
We report the cloning, genomic organization and sequence of the mouse alpha-CALC and beta-CALC genes. The two genes share extensive sequence homology. The transcription units of both genes contain 6 exons. Transcripts of the alpha-CALC gene were found to alternatively include exon 4 or exons 5 and 6. For the beta-CALC gene exon 4 was not detected in transcripts derived from this gene. The predicted mouse alpha-CGRP was found to be identical to rat alpha-CGRP, however, beta-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function.
Thomas
P M
PM
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Nasonkin
I
I
Zhang
H
H
Gagel
R F
RF
Cote
G J
GJ
D000818:Animals; D001483:Base Sequence; D002116:Calcitonin / Q000235:genetics*; D015740:Calcitonin Gene-Related Peptide / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D017385:Sequence Homology
D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide