title: Synthesis and characterization of (99m)Tc- and (188)Re-complexes with a diamido-dihydroxymethylenephosphine-based bifunctional chelating agent (N(2)P(2)-BFCA).
abstract: A diamido-dihydroxymethylenephosphine (N(2)P(2)) bifunction chelating agent (BFCA) was shown to form well-defined (99m)Tc- and (188)Re-chelate structures. The 4, 4-bis [bis-hydroxymethyl-phosphonyl-propylcarbonmoyl]-butyric acid bifunctional chelating agent (N(2)P(2)-BFCA) formed stable complexes with (99m)Tc and (188)Re in >95% yield with high radiochemical purity (RCP). The biodistribution of the (99m)Tc- and (188)Re-N(2)P(2)-BFCAs after intravenous injection studied in normal mice showed the activity was excreted primarily via renal-urinary pathway indicating their use for labeling peptides with (99m)Tc and (188)Re.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Center, Mumbai, India. kanchan@apsara.barc.ernet.in
authors.forename: K K
authors.initials: KK
authors.lastname: Kothari
authors.forename: H
authors.initials: H
authors.lastname: Gali
authors.forename: K R
authors.initials: KR
authors.lastname: Prabhu
authors.forename: N
authors.initials: N
authors.lastname: Pillarsetty
authors.forename: N K
authors.initials: NK
authors.lastname: Owen
authors.forename: K V
authors.initials: KV
authors.lastname: Katti
authors.forename: T J
authors.initials: TJ
authors.lastname: Hoffman
authors.forename: W A
authors.initials: WA
authors.lastname: Volkert
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D004355:Drug Stability; D051379:Mice; D011868:Radioisotopes; D012211:Rhenium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D017556:Technetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D002614:Chelating Agents; D011868:Radioisotopes; D017556:Technetium Compounds; D012211:Rhenium