[Study on essence of syndrome of traditional Chinese medicine in liver cirrhotic patients].
OBJECTIVE
To explore the essence of Syndrome of traditional Chinese medicine (TCM) in cirrhostic patients.


METHODS
Eighty patients of post-hepatitis-B cirrhosis were classified, according to Syndrome Differentiation of TCM, into three types: the Liver-Qi Stagnancy and Spleen-Deficiency type (A), the Qi-Stagnancy and blood stasis type (B) and the Heat Stagnancy and blood stasis type (C), serum hyaluronic acid (HA), adenosine deaminase (ADA), glutathione-s-epoxide transferase (GST), N-acetyl-beta-D-glucosaminidase (NAG), hydroxyproline (HYP) and procollagen type III (PC III) of 52 patients were determined before and after treatment based on Syndrome Differentiation.


RESULTS
Serum HA, ADA, GST and PC III of patients were significantly higher than those of the healthy control (P < 0.01), and the change of these parameters were closely associated with types of Syndrome, which were, in turn, C > B > A > control, the difference between groups was significant (P < 0.05, P < 0.01). After treatment, the liver function and above-mentioned serologic parameters were significantly improved (P < 0.05, P < 0.01).


CONCLUSIONS
Syndrome of cirrhosis patients has its inherent essential content. Serum HA, ADA, GST and PC III could serve as objective indexes for establishing Syndrome Differentiation and guiding treatment. TCM treatment of cirrhosis based on Syndrome Differentiation has good effect with beneficial anti-fibrotic action.
Wu
J
J
First Affiliated Hospital of Zhejiang Medical University, Hangzhou (310003).
Zhang
L
L
D000243:Adenosine Deaminase / Q000097:blood; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005982:Glutathione Transferase / Q000097:blood; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000821:virology; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged
D006820:Hyaluronic Acid; D005982:Glutathione Transferase; D000243:Adenosine Deaminase