[Effect of growth hormone on the outcome of ovulation induction in patients with polycystic ovary syndrome].
OBJECTIVE
To study the effect of growth hormone (GH) on the outcome of ovulation induction in patients with polycystic ovary syndrome (PCOS).


METHODS
We examined serum sex hormone, GH and insulin like growth factor-II (IGF-II) basal levels by radioimmunoassay in 130 PCOS patients and 107 normal women. In addition, we observed the effect of GH on the outcome of ovulation induction in 7 poor responders to human menopausal gonadotropin (hMG) treatment.


RESULTS
The mean serum GH level is (2.50 +/- 1.33) micrograms/L and (1.04 +/- 0.47) micrograms/L respectively in nonobese and obese PCOS patients which were significantly lower than those in controls [(5.30 +/- 2.26) micrograms/L, (2.95 +/- 1.49) micrograms/L respectively, P < 0.05]. The mean serum IGF-II level is (136 +/- 27) nmol/L in the obese PCOS patients, significantly greater than those in nonobese PCOS and controls (P < 0.05). When we used GH with hMG in 7 poor responders, the total amount of hMG required decreased from 1 to 12 amples and the duration of treatment shortened as compared with hMG alone.


CONCLUSIONS
There is abnormal GH secretion in patients with PCOS, GH may improve the outcome of ovulation induction by gonadotropin.
Wang
Y
Y
Department of Obstetric and Gynecology, Third Hospital, Peking University, Beijing 100083, China.
Li
M
M
Yang
C
C
D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*
D013006:Growth Hormone