title: Options for preserving the larynx in patients with advanced laryngeal and hypopharyngeal cancer.
abstract: The introduction of newer surgical and combined-modality approaches to organ preservation in patients with advanced laryngeal or hypopharyngeal cancer is the most exciting clinical frontier in head and neck cancer treatment today. The use of these techniques at other sites, the exploration of improved methods for patient selection and tumor assessment, and the development of newer combination regimens will need to be rigorously studied in future clinical trials. In all these efforts, the major focus must remain on improving survival. This article reviews the latest developments in organ-preservation strategies and techniques for patients with advanced laryngeal or hypopharyngeal cancer.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, 1904 Taubman Center, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0312, USA. gregwolf@umich.edu
authors.forename: G T
authors.initials: GT
authors.lastname: Wolf
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000601:surgery* / Q000628:therapy; D007822:Laryngeal Neoplasms / Q000601:surgery* / Q000628:therapy; D019060:Minimally Invasive Surgical Procedures; D020360:Neoadjuvant Therapy; D018714:Radiotherapy, Adjuvant; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index
chemical_list: D000970:Antineoplastic Agents