title: Lens fluorophotometry after trabeculectomy in primary open-angle glaucoma.
abstract: OBJECTIVE
  To evaluate the loss of lens transparency incurred by patients undergoing trabeculectomy.
  
  
  METHODS
  A prospective cohort study.
  
  
  METHODS
  Data corresponding to 33 eyes of 33 consecutive patients with primary open-angle glaucoma (POAG) subjected to trabeculectomy (group 1) were compared with those corresponding to 12 eyes of 12 patients with POAG receiving topical antiglaucomatous treatment (group 2).
  
  
  METHODS
  Lens fluorophotometry was performed on the group 1 patients before and 12 months after surgery. In group 2, fluorophotometry was conducted at the onset of the study and at 12 months of follow-up.
  
  
  METHODS
  Starting and final lens autofluorescence and transmittance values corresponding to each subject group were compared.
  
  
  RESULTS
  In group 1, starting and final autofluorescence was 556.3 +/- 184.3 and 691.1 +/- 179.3 Eq ng/ml, and starting and final transmittance was 0.78 +/- 0.11 and 0.67 +/- 0.14, respectively. Respective values for group 2 were 574.3 +/- 94.8 and 595.2 +/- 107.0 Eq ng/ml and 0.72 +/- 0.17 and 0.71 +/- 0.16. The mean change between final and initial autofluorescence was statistically different between groups (134.7 +/- 123.7, group 1, 20.9 +/- 25.1 Eq ng/ml, group 2; P < 0.001). Similarly, a significant difference (P < 0.001) in transmittance change was observed between the surgery and control groups (-0.11 +/- 0.072, group 1; 0.02 +/- 0.008, group 2)
  
  
  CONCLUSIONS
  It was demonstrated by lens fluorophotometry that trabeculectomy in POAG leads to a loss in lens transparency.
authors.affiliation: Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense, 28005 Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Lazaro
authors.forename: Jose M
authors.initials: JM
authors.lastname: Benitez-del-Castillo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Castillo
authors.forename: Julian
authors.initials: J
authors.lastname: Garcia-Feijoo
authors.forename: Juana M
authors.initials: JM
authors.lastname: Macias
authors.forename: Julian
authors.initials: J
authors.lastname: Garcia-Sanchez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000175:diagnosis* / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D015590:Fluorophotometry; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007908:Lens, Crystalline / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D014130:Trabeculectomy / Q000009:adverse effects*; D014792:Visual Acuity