[Changes of serum il-6 and CRP after chemotherapy in patients with ovarian carcinoma].
The levels of IL-6, CRP and TPS were measured in 38 patients with ovarian carcinoma in different histological types and clinical stages. The values IL-6, CRP and TPS were determined before and after chemotherapy. Pretreatment levels of IL-6, CRP and TPS were significantly increased in carcinoma patients relatively to the control group. The frequency of increased results and absolute value of IL-6 and TPS levels showed tendency to significant increase with the stage of disease. The highest values of IL-6 were observed in patients with serous and mucous carcinoma. The levels of IL-6, CRP and TPS were decreased above cut off values in patients with remission, and did not changed in patients with progression and stabilization disease. The results suggest that IL-6 especially in the combination with CRP and TPS may be useful in the diagnosis and the evaluation of therapy of patients with ovarian carcinoma.
Zakrzewska
I
I
Zakład Laboratoryjnej Diagnostyki Klinicznej AM w Białymstoku.
Poznański
J
J
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002277:Carcinoma / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D002352:Carrier Proteins; D002373:Cyclic AMP Receptor Protein / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D010455:Peptides / Q000097:blood*; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D002373:Cyclic AMP Receptor Protein; D015850:Interleukin-6; D010455:Peptides; C089984:tissue polypeptide specific antigen
Zmiany stezenia IL-6 i CRP w surowicy chorych na nabłonkowe nowotwory jajnika po leczeniu cytostatycznym.