Antiapoptotic proteins. The bcl-2 and inhibitor of apoptosis protein families.
The balance between pro- and antiapoptotic proteins can determine cellular fate. In this regard, the Bcl-2 and IAP protein families have evolved as highly conserved regulators of cell death. A further testament to their critical roles in maintaining balance between cell life and death may be the increasing implication of Bcl-2 and TAP proteins in the pathologies of human diseases. Although much has been learned about these families of proteins, future studies of the Bcl-2 and IAP families are sure to hold more exciting discoveries and will continue to reveal new strategies for combating human diseases.
Deveraux
Q L
QL
The Burnham Institute Program on Apoptosis and Cell Death Research, La Jolla, California 92037, USA.
Schendel
S L
SL
Reed
J C
JC
D017209:Apoptosis / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins / Q000502:physiology*; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology*
D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2