title: [Laxative effect of poly(ethylene oxide) 1500 per se and in combination with bisacodyl].
abstract: The results of experiments on rats showed evidence of a laxative activity of poly(ethylene oxide) (PEO-1500) upon peroral administration. This effect is related to the polymer ability of retaining water, which increases the intestinal content volume and accelerates the intestinal peristaltic activity. The anticonstipative effect of PEO-1500 is comparable to that of forlax, but less pronounced than the effect of bisacodyl. The joint administration of PEO-1500 with bisacodyl produces a synergistic effect exceeding the separate action of both agents.
authors.affiliation: Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Smol'iakova
authors.forename: G A
authors.initials: GA
authors.lastname: Chernysheva
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
mesh_terms: D000818:Animals; D001726:Bisacodyl / Q000494:pharmacology*; D002400:Cathartics / Q000494:pharmacology*; D004357:Drug Synergism; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D007420:Intestine, Large / Q000187:drug effects / Q000502:physiology; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats
chemical_list: D002400:Cathartics; D001726:Bisacodyl; D011092:Polyethylene Glycols
vernacular_title: Slabitel'nyĭ éffekt poliétilenoksida 1500 per se i pri sovmestnom primenenii s bisakodilom.