Trichostatin A, an inhibitor of histone deacetylase, inhibits hypoxia-induced angiogenesis.
Trichostatin A (TSA), a hydroxamate-type inhibitor of mammalian histone deacetylases has been reported to inhibit angiogenesis both in vitro and in vivo. TSA inhibits hypoxia-induced production of the angiogenic mediator vascular endothelial cell growth factor (VEGF) by tumour cells and also inhibits directly endothelial cell migration and proliferation. HDAC inhibitors such as TSA are currently of major interest as potential anticancer therapeutics, largely because of their well-documented properties of inhibiting proliferation and inducing apoptosis of tumour cells. The finding that HDAC appears to be a critical regulator of angiogenesis in addition to tumour cell growth will heighten interest in the development of HDAC inhibitors as potential anticancer drugs.
Williams
R J
RJ
Prolifix Ltd., 91 Milton Park, Abingdon, Oxon OX14 4RY, UK. r.williams@prolifix.co.uk
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D016228:Endothelial Growth Factors / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D006877:Hydroxamic Acids / Q000627:therapeutic use*; D000860:Hypoxia / Q000150:complications* / Q000473:pathology; D008222:Lymphokines / Q000037:antagonists & inhibitors; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014407:Tumor Cells, Cultured; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D020533:Angiogenesis Inhibitors; D016228:Endothelial Growth Factors; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C012589:trichostatin A