title: Three-component coupling via the squarate ester cascade as a concise route to the bioactive triquinane sesquiterpene hypnophilin.
abstract: [reaction: see text] A squarate ester cascade is used to provide in one step, via the coupling of three reactants, a highly oxygenated linear triquinane product. The latter is transformed in nine steps into hypnophilin. The access route involves a combination of chlorination, reduction, dehydration, and oxidation maneuvers in the proper sequence.
authors.affiliation: Evans Chemical Laboratories, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Geng
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Leo A
authors.initials: LA
authors.lastname: Paquette
mesh_terms: D010084:Oxidation-Reduction; D012717:Sesquiterpenes / Q000138:chemical synthesis*
chemical_list: D012717:Sesquiterpenes; C446680:hypnophilin