title: Case report. Successful treatment of two cases of post-surgical sternal osteomyelitis, due to Candida krusei and Candida albicans, respectively, with high doses of triazoles (fluconazole, itraconazole).
abstract: Two female patients, aged 75 and 59 years, respectively, with candidal sternal osteomyelitis were successfully treated by the administration of triazoles. Both had developed post-operative wound infection after sternotomy for coronary artery by-pass grafting. Sternal osteomyelitis was confirmed by bone scans with technetium 99Tc and gallium 67Ga. The cultures, from the pus draining at the site of the sternotomy scar, grew Candida krusei in the first case. The fistula closed after a 9-week course of itraconazole therapy (800 mg daily, followed by 600 mg daily) and the patient completed a 6-month period of therapy. The second patient had underlying diabetes mellitus. Post-operatively she developed two fistulae draining pus on the sternum. The pus cultures grew C. albicans. Initial treatment with oral fluconazole (400 mg daily) failed. Subsequent treatment with liposomal amphotericin B also failed. A dramatic improvement was noted when the patient received high doses of fluconazole (800 mg daily). The fistulae gradually closed after 1 month. Oral fluconazole was continued for 6 months. The cure was confirmed by bone scans. Three years later, both patients remained well.
authors.forename: G
authors.initials: G
authors.lastname: Petrikkos
authors.forename: A
authors.initials: A
authors.lastname: Skiada
authors.forename: H
authors.initials: H
authors.lastname: Sabatakou
authors.forename: A
authors.initials: A
authors.lastname: Antoniadou
authors.forename: T
authors.initials: T
authors.lastname: Dosios
authors.forename: H
authors.initials: H
authors.lastname: Giamarellou
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy / Q000209:etiology*; D011183:Postoperative Complications; D013249:Sternum / Q000601:surgery
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole