title: Bovine pancreatic secretion in the first week of life: potential involvement of intestinal CCK receptors.
abstract: The aim of this study was to evaluate pancreatic juice secretion of calves in the first postnatal days, and determine a potential involvement of cholecystokinin (CCK) and intestinal CCK receptor in its regulation. Nine neonatal Friesian calves (five controls and four treated intraduodenally with FK480, a CCK-A receptor antagonist) were surgically fitted with a pancreatic duct catheter and a duodenal cannula before the first colostrum feeding. Collections of pancreatic juice and duodenal luminal pressure recordings were started early after recovery from anaesthesia and continued for 6 days. From day 2 or 3 of life, periodic fluctuations in pancreatic secretions were observed in concert with duodenal myoelectric motor complex (MMC) and variations in plasma pancreatic polypeptide (PP) concentrations. Intraduodenal administration of FK480 reduced pancreatic juice secretion while intravenous infusion of CCK had no effect. Immunocytochemistry indicated an association of mucosal CCK-A and -B receptors with neural components of the small intestine. In conclusion, periodic activity of the exocrine pancreas exists in neonatal calves soon after birth and local neural intestinal CCK-A receptors could be partly responsible for the modulation of neonatal calf pancreatic secretion.
authors.affiliation: The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Science, 05-110 Jabłonna, Poland.
authors.forename: Romuald
authors.initials: R
authors.lastname: Zabielski
authors.forename: Jean
authors.initials: J
authors.lastname: Morisset
authors.forename: Paweł
authors.initials: P
authors.lastname: Podgurniak
authors.forename: Véronique
authors.initials: V
authors.lastname: Romé
authors.forename: Marzena
authors.initials: M
authors.lastname: Biernat
authors.forename: Christine
authors.initials: C
authors.lastname: Bernard
authors.forename: Jean Alain
authors.initials: JA
authors.lastname: Chayvialle
authors.forename: Paul
authors.initials: P
authors.lastname: Guilloteau
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001570:Benzodiazepinones / Q000494:pharmacology; D002417:Cattle; D002766:Cholecystokinin / Q000494:pharmacology; D003126:Colostrum; D007211:Indoles / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000378:metabolism*; D008892:Milk; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D010191:Pancreatic Polypeptide / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology; D019518:Postprandial Period; D051381:Rats; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001570:Benzodiazepinones; D007211:Indoles; D010446:Peptide Fragments; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; C053399:cholecystokinin 9; C082966:FR 120480; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin