title: Palladium-catalyzed monoarylation of nitroalkanes.
abstract: A general protocol for the Pd-catalyzed-arylation of nitroalkanes is described. Substituted aryl bromides as well as aryl chlorides can be coupled efficiently with a variety of nitroalkanes under mild conditions to selectively yield the monoarylated products. This method tolerates a number of functional groups including ketones, esters, and olefins. Notably, the arylation of nitroalkanes can be effected chemoselectively over ketone and ester arylation.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Erasmus M
authors.initials: EM
authors.lastname: Vogl
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D002384:Catalysis; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009578:Nitrobenzenes / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
chemical_list: D000473:Alkanes; D009574:Nitro Compounds; D009578:Nitrobenzenes; D010165:Palladium