title: [Systemic manifestations of idiopathic inflammatory myopathies--part two].
abstract: The aim of the investigation was to establish if the finding of immunoserologic and pathohistologic parameters of the altered humoral immune response in patients with dermatopolymyositis was associated with the occurrence of more severe clinical patterns of the diseases followed by general symptoms and the affection of visceral organs. Sensitivity, specificity, accuracy, positive and negative prediction of immunologic parameters of the disease were determined compared to the occurrence of certain systemic manifestations of the disease. Significant (80-100%) correlation of systemic manifestations with the altered immunoserologic and histopathologic parameters of the disease was confirmed, so that it could be assumed that pathologic humoral response had a significant role in the onset of systemic manifestations during dermatopolymyositis. Predictive value of indicators was of the utmost importance. If the increased values of immune complexes, vasculitis in the muscle and the other cited indicators of the altered humoral response were confirmed in a patient, more severe course of the disease could be expected, which was of practical value for the planning of therapeutic approach, estimation of the disease course and its prognosis.
authors.forename: Lj
authors.initials: Lj
authors.lastname: Petrovic-Rackov
authors.forename: Z
authors.initials: Z
authors.lastname: Andjelkovic
authors.forename: M
authors.initials: M
authors.lastname: Popovic
authors.forename: V
authors.initials: V
authors.lastname: Tatic
authors.forename: R
authors.initials: R
authors.lastname: Spaic
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D003882:Dermatomyositis / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D017285:Polymyositis / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D012217:Rheumatoid Factor / Q000032:analysis
chemical_list: D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D003165:Complement System Proteins; D012217:Rheumatoid Factor
vernacular_title: Sistemske manifestacije idiopatskih inflamatornih miopatija--drugi deo.