Endothelin-1 synthesis reduced by red wine.
Statistical evidence of reduced coronary heart disease in areas of high wine consumption has led to the widespread belief that wine affords a protective effect. Although moderate drinking of any alcohol helps to reduce the incidence of coronary heart disease, there is no clear evidence that red wine confers an additional benefit. Here we show that red wines strongly inhibit the synthesis of endothelin-1, a vasoactive peptide that is crucial in the development of coronary atherosclerosis. Our findings indicate that components specific to red wine may help to prevent coronary heart disease.
Corder
R
R
William Harvey Research Institute, Barts & the London School of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. r.corder@qmul.ac.uk
Douthwaite
J A
JA
Lees
D M
DM
Khan
N Q
NQ
Viseu Dos Santos
A C
AC
Wood
E G
EG
Carrier
M J
MJ
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D003324:Coronary Artery Disease / Q000209:etiology / Q000517:prevention & control*; D004032:Diet; D019332:Endothelin-1 / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D005419:Flavonoids; D005786:Gene Expression Regulation; D006801:Humans; D010636:Phenols / Q000494:pharmacology; D010766:Phosphorylation; D011108:Polymers / Q000494:pharmacology; D059808:Polyphenols; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D014920:Wine
D019332:Endothelin-1; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D011505:Protein-Tyrosine Kinases