title: Ceruminolytic efficacy in adults versus children.
abstract: OBJECTIVE
  An inexpensive, nontoxic ceruminolytic with reasonable efficacy that can be used by the patient or their caregivers at home could represent significant financial saving for patients and health care systems. The purpose of this study was to compare two simple ceruminolytics for in vitro efficacy.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Thirty-six children and 33 adults presenting to a community family practice clinic who had cerumen occluding at least one external auditory canal were randomly assigned to compare use of 10% aqueous sodium bicarbonate and 2.5% aqueous acetic acid as ceruminolytics in occlusive cerumen.
  
  
  RESULTS
  We were unable to demonstrate a difference between in vivo efficacy of these two ceruminolytic solutions, but both solutions were significantly more efficacious in children than adults.
  
  
  CONCLUSIONS
  There is a role for these ceruminolytics in children with occlusive cerumen, but adults would be better treated in another way.
authors.affiliation: Department of Pediatric Otolaryngology, Children's Hospital of Buffalo,New York, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Carr
authors.forename: R L
authors.initials: RL
authors.lastname: Smith
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000367:Age Factors; D002571:Cerumen / Q000737:chemistry / Q000187:drug effects*; D002648:Child; D004311:Double-Blind Method; D006801:Humans; D010032:Otitis Externa / Q000209:etiology / Q000628:therapy*; D017693:Sodium Bicarbonate / Q000008:administration & dosage / Q000494:pharmacology*; D012996:Solutions; D016896:Treatment Outcome; D014867:Water
chemical_list: D012996:Solutions; D014867:Water; D017693:Sodium Bicarbonate; D019342:Acetic Acid