[The induction of transforming growth factor-beta 1 in reparative process of mouse experimental alveolar bone defect].
OBJECTIVE
To study the induction of transforming growth factor-beta 1(TGF-beta 1) in reparative process of mouse experimental alveolar bone defect.


METHODS
Alveolar bone defect were made in 20 mice at 1/1 region. In twelve mice (experimental group), the defect was filled with gelatin sponge infiltrated by TGF-beta 1 solution; in eight mice (control group), the defect was filled with gelatin sponge. The peripheral tissue coating alveolar bone defect was harvested for histopathologic study after 1 week, 2 weeks and 1 month, 3 months.


RESULTS
The main histopathologic changes were: 1. experimental group: inflammatory cell infiltration (1W); inflammatory cell disappearance, fibroblast and capillary tachyauxesis, osteoid tissue and small amount neoformative bone tissue appearance (2 W); fibrous tissue decrease, neoformative bone tissue enlarging and maturity(1-3 M). 2. Control group; inflammatory cell infiltration (1W); inflammatory cell disappearance, fibroblast and capillary tachyauxesis (2W); osteoblast appearance around bone defect (1M); small amount neoformative bone tissue around bone defect.


CONCLUSIONS
TGF-beta 1 can induce alveolar bone regeneration.
Zhao
S
S
Department of Oral Medicine, College of Stomatology, Xi'an Medical University, Xi'an 710004, China.
Wang
Q
Q
Cheng
Z
Z
D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D005260:Female; D051379:Mice; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1
C508961:Tgfb1 protein, mouse; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1