title: Study of formulation parameters by factorial design in metoprolol tartrate matrix systems.
abstract: The study of formulation parameters in hydrophilic matrices of metoprolol tartrate by 2(3) factorial design wass made. We compared the dissolution profiles of two hydrophilic polymers (hydroxypropylmethylcellulose and hydroxyethylcellulose) at high and low concentrations and in the presence or absence of an insoluble excipient (calcium hydrogen phosphate dihydrate). The results showed that the presence of an insoluble excipient influenced almost all of the dissolution parameters.
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, University of Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Miñarro
authors.forename: E
authors.initials: E
authors.lastname: García-Montoya
authors.forename: J M
authors.initials: JM
authors.lastname: Suñé-Negre
authors.forename: J R
authors.initials: JR
authors.lastname: Ticó
mesh_terms: D019540:Area Under Curve; D004339:Drug Compounding; D005079:Excipients; D008790:Metoprolol / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers; D012995:Solubility
chemical_list: D005079:Excipients; D011108:Polymers; D008790:Metoprolol