Current management of perianal intraepithelial neoplasia.
The surgical management of intraepithelial perianal neoplasms is straightforward. The goal is complete locoregional control of the disease. Success is determined at the time of operation by frozen section analysis and reexcision if necessary. Procedures that will interfere with sphincter function should be delayed in favor of alternative treatment with radiotherapy or chemoradiotherapy. Close long-term follow-up is necessary to ensure the best possible outcome should a lesion recur.
Branum
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Harrisonburg Surgical Associates, Virginia 22802, USA.
D001005:Anus Neoplasms / Q000209:etiology / Q000601:surgery* / Q000628:therapy; D002278:Carcinoma in Situ / Q000209:etiology / Q000601:surgery* / Q000628:therapy; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy / Q000379:methods; D030361:Papillomavirus Infections / Q000150:complications / Q000601:surgery* / Q000628:therapy