title: [Study on epidemic of drug-resistant tuberculosis in Shandong province, China].
abstract: OBJECTIVE
  To establish the surveillance system for drug resistance of tuberculosis according to WHO and IUATLD guidelines, and to evaluate the initial and acquired drug resistance in Shandong province.
  
  
  METHODS
  30 of 141 counties/cities were randomly selected as surveillance points by cluster sampling from April to October 1997, in each of which 36 cases with smear positive pulmonary tuberculosis were continuously observed. Identification and susceptibility tests were done in all culture positive samples.
  
  
  RESULTS
  The total frequency of drug resistance was 23.4%, initial drug resistance 17.6%, initial multi-drug resistance 2.9%, acquired drug resistance 50.0%, acquired multi-drug resistance 19.6%.
  
  
  CONCLUSIONS
  The results suggest that the initial drug resistance still ranks high in Shandong province, National TB Control Program should be further strengthened.
authors.affiliation: Tuberculosis Control Center, Ministry of Public Health, China, Beijing 101149.
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Duanmu
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D004352:Drug Resistance, Microbial / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents