Long-chain polyunsaturated fatty acids (LC-PUFA) during early development: contribution of milk LC-PUFA to accretion rates varies among organs.
Long-chain polyunsaturated fatty acids (LC-PUFA) accretion (essential for growth and neural development) was studied from late fetal throughout weaning age in the ferret, a species with maternal LC-PUFA sufficiency during pregnancy and lactation. The data show that a) accretion rate of LC-PUFA is rapid during early postnatal development, b) milk LC-PUFA decrease during lactation, c) adipose tissue LC-PUFA level is directly related to milk LC-PUFA level, while accretion in brain and liver exceeds dietary intake, d) accretion of arachidonic acid occurs earlier than docosahexaenoic acid, suggesting earlier development of n6-fatty acid endogenous synthesis.
Hamosh
M
M
Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
Henderson
T R
TR
Kemper
M A
MA
Orr
N M
NM
Gil
A
A
Hamosh
P
P
D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry; D004032:Diet; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000032:analysis / Q000502:physiology*; D005260:Female; D005289:Ferrets / Q000196:embryology / Q000254:growth & development*; D006801:Humans; D007774:Lactation; D008099:Liver / Q000254:growth & development; D008321:Mammary Glands, Animal / Q000737:chemistry / Q000378:metabolism; D008892:Milk / Q000737:chemistry*; D011247:Pregnancy
D005231:Fatty Acids, Unsaturated