Cadherin expression in the eye.
E(pithelial)-cadherin and N(eural)-cadherin are transmembrane cell-cell adhesion molecules, belonging to the subfamily of classical cadherins. The expression of E- and N-cadherin is spatiotemporally regulated and associated with a variety of normal morphogenetic events. The expression of E- and N- cadherin is also involved in carcinogenesis. E-cadherin functions as a tumor-suppressor. N-cadherin, however, is associated with cancer progression. The study of the expression pattern of E- and N-cadherin in the normal and tumorous eye is the aim of our research.
Van Aken
E
E
Dpt. Of Ophthalmology, Ghent University Hospital, Belgium.
Papeleu
P
P
De Potter
P
P
De Laey
J J
JJ
Mareel
M
M
D000818:Animals; D015820:Cadherins / Q000032:analysis*; D003315:Cornea / Q000378:metabolism; D015536:Down-Regulation; D005123:Eye / Q000378:metabolism*; D005128:Eye Diseases / Q000378:metabolism*; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism; D010857:Pigment Epithelium of Eye / Q000737:chemistry; D012016:Reference Values; D019572:Retinal Neoplasms / Q000378:metabolism; D012175:Retinoblastoma / Q000378:metabolism; D014018:Tissue Distribution
D015820:Cadherins