[Study on polymorphism of human leukocyte antigen I in patients with endometriosis].
OBJECTIVE
To study the possibility of a correlation between polymorphism of human leukocyte antigen (HLA)-I antigen and occurrence of endometriosis (Em).


METHODS
Polymorphism of HLA-I A and B locations were detected by mini-lymphocytotoxin test in 40 surgically proven Em patients and 50 normal controls. The frequency of different antigens on both A and B sites were compared between the 2 groups.


RESULTS
No significant difference of the antigen frequency at HLA-I A site was shown between Em and control groups. However, at HLA-I B site, frequency of B46 antigen in Em group was significantly higher [33% Vs 16%, P < 0.05, relative risk (RR) 2.5278] and frequency of B48 antigen in Em group was significantly lower (3% Vs 16% P < 0.05, RR 0.1346) as compared with those of the controls.


CONCLUSIONS
The occurrence of Em may be associated with the presence of HLA-I B46 antigen. On the contrary, the HLA-I B48 antigen might play a protective role against Em.
Wang
X
X
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011, China.
Lin
Q
Q
Guo
S
S
D000328:Adult; D004715:Endometriosis / Q000235:genetics / Q000276:immunology*; D005260:Female; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic
D006680:HLA Antigens