title: The impact of side-effects of antipsychotic agents on life satisfaction of schizophrenia patients: a naturalistic study.
abstract: This study compared the impact of side-effects of antipsychotic treatment, clinical and psychosocial factors on the subjective quality of life (QOL) of hospitalized patients. We surveyed 161 patients meeting DSM-IV criteria for schizophrenia stabilized on conventional and atypical antipsychotic drugs using standardized measures of adverse events, psychopathology, psychosocial variables, and perceived QOL. We found that patients with adverse events reported less satisfaction with life domains of subjective feelings and general activities than asymptomatic patients. Patients treated with conventional and novel antipsychotic agents had comparable QOL ratings. Multiple regression analysis showed total variance in QOL ratings as follows: psychosocial factors, 20.9%; clinical symptoms and associated distress, 10.1%; adverse effects, 3.2%. Thus, medication side-effects influence subjective quality of life of schizophrenia inpatients significantly less than other clinical and psychosocial factors. Patient's subjective response to these events rather than their number is more predictive of QOL.
authors.affiliation: Institute for Psychiatric Studies, Sha'ar Menashe Mental Health Center, Hadera, Israel. shrritsner@matat.health.gov.il
authors.forename: Michael
authors.initials: M
authors.lastname: Ritsner
authors.forename: Alexander
authors.initials: A
authors.lastname: Ponizovsky
authors.forename: Jean
authors.initials: J
authors.lastname: Endicott
authors.forename: Yakov
authors.initials: Y
authors.lastname: Nechamkin
authors.forename: Boris
authors.initials: B
authors.lastname: Rauchverger
authors.forename: Henry
authors.initials: H
authors.lastname: Silver
authors.forename: Ilan
authors.initials: I
authors.lastname: Modai
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D010549:Personal Satisfaction; D011788:Quality of Life / Q000523:psychology*; D012044:Regression Analysis; D012559:Schizophrenia / Q000188:drug therapy*; D018709:Statistics, Nonparametric
chemical_list: D014150:Antipsychotic Agents