[The expression of cathepsin-D in salivary adenoid cystic carcinoma].
OBJECTIVE
To investigate the relationship between Cathepsin-D(Cath-D) and the prognosis of patients with salivary adenoid cystic carcinoma (SACC).


METHODS
The immunoactivity of Cath-D of 52 cases with SACC was determined by immunohistochemistry method (Streptavidin-Biotin method). The relationship between Cath-D and the histological type, clinical stage, local recurrence, distant metastasis of the tumor and survival rate of the patients with SACC were analysed.


RESULTS
Statistical analysis showed that the expression levels of Cath-D were correlated positively with distant metastasis potential and clinical stage (P < 0.05), and had no significant relation with histological type, local recurrence and survival rate (P > 0.05).


CONCLUSIONS
Cath-D can facilitate invasiveness and distant metastasis of SACC; evaluation of Cath-D can act as a predictor of distant metastasis of SACC and direct the clinical treatment.
Peng
X
X
Department of Oral Maxillofacial Surgery, School of Stomatology, Beijing Medical University, Beijing 100081, China.
Yu
G
G
Gao
Y
Y
D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000201:enzymology / Q000473:pathology*; D002402:Cathepsin D / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012468:Salivary Gland Neoplasms / Q000201:enzymology / Q000473:pathology*; D016019:Survival Analysis
D002402:Cathepsin D