[Properties of artificial evolution of proteins and peptides].
In vitro evolution is used to study protein sequences, structures, and interactions and to obtain proteins with new properties. To analyze the specific features of this process in experiments with phage display, we studied the amino acid composition of selected sequences, constructed a matrix of amino acid substitutions, and identified pairs of coadaptive substitutions. Amino acid frequency proved to be tightly associated with the number of corresponding codons; numerous correlated substitutions were found.
Valuev
V P
VP
valuev@bionet.nsc.ru
Afoninkov
D A
DA
Petrenko
O I
OI
Grigorovich
D A
DA
D019943:Amino Acid Substitution; D019143:Evolution, Molecular; D010455:Peptides / Q000737:chemistry / Q000235:genetics*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D010455:Peptides; D011506:Proteins
Issledovanie svoĭstv iskusstvenno évoliutsii belkov i peptidov.