Generation of mink cell focus-inducing retroviruses: a model for understanding how viral-viral and viral-cellular interactions can result in biological consequences.
Using neoplastic cell lines as substrates for vaccine development could inadvertently result in viral-viral or viral-cellular interactions whose biological consequences are unclear. In this review, the generation of mink cell focus-inducing (MCF) retroviruses in the mouse is discussed as a model for understanding how viral-viral and viral-cellular interactions can result in the generation of new retroviruses with pathological consequences.
Ruscetti
S K
SK
Basic Research Laboratory, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702-1201, USA.
D000818:Animals; D007942:Leukemia, Experimental / Q000821:virology*; D008561:Membrane Fusion; D051379:Mice; D008908:Mink Cell Focus-Inducing Viruses / Q000472:pathogenicity / Q000502:physiology*; D008954:Models, Biological; D014407:Tumor Cells, Cultured