[Local chemotherapy by fibrobronchoscopy for advanced bronchogenic carcinoma].
OBJECTIVE
To observe the effectiveness of treatment in the patients with advanced bronchogenic carcinoma of local chemotherapy with fibrobronchoscopy, combined with systematic chemotherapy.


METHODS
40 patients with advanced bronchogenic carcinoma were divided into the tested group (20 patients) and the control group (20 patients) randomly. By fibrobronchoscopy with its matched injecting needle, carboplatin 300 mg were injected into the centre of the tumor and the surroundings, combined with the routine carboplatin and etoposide (CE) regimen. While the control group was treated only by intravenous chemotherapy with the routine CE regimen.


RESULTS
In the 20 patients with local chemotherapy by fibrobronchoscopy combined with intravenous chemotherapy, 7 cases (35%) were completely cured and 11 cases (55%) showed partial recovery, other 2 cases without change. The 90% effective rate was significantly higher than 55% of the control group (P < 0.05).


CONCLUSIONS
The local chemotherapy by fibrobronchoscopy can remarkably reduce the size of tumor, and relieve symptom of dyspnea. Intravenous chemotherapy alleviated the obstruction caused by tracheal or bronchial neoplasms. The combined therapies led to much better therapeutic effect and symptomatic relief than those by the routine CE regimen.
Liu
M
M
Department of Pulmonary Disease, Yishui Centra Hospital, Shandong 276400, China.
Ma
P
P
Lu
Z
Z
D000368:Aged; D001999:Bronchoscopy; D002283:Carcinoma, Bronchogenic / Q000188:drug therapy* / Q000401:mortality; D004358:Drug Therapy; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome