Biochemical and ultrastructural alterations in rat after hyperoxic treatment: effect of taurine and hypotaurine.
The cell ultrastructure and some detoxifying enzyme activities were studied in skeletal muscles of young rats kept for 84 h under normobaric hyperoxia (95% O2) or normoxia as control. Rat were injected i.p.. Every 12 h either with 1 ml saline, 1 ml saline+30 mg hypotaurine or 1 ml saline+30 mg taurine. Ultrastructural observation revealed an highly protective effect on tissue damages due to hyperoxia in taurine-treated rats and, at less extent, in hypotaurine-treated ones. Enzymatic assays suggest a different mechanism of the two molecules in their protective action.
Pitari
G
G
Dipartimento di Biologia di Base ed Applicata, Università di L'Aquila, Italy.
Duprè
S
S
Ragnelli
A M
AM
Aimola
P
P
Di Giulio
C
C
Amicarelli
F
F
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D018496:Hyperoxia / Q000201:enzymology*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*
D013654:Taurine; C003949:hypotaurine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase