title: Measuring quality of life in women with vertebral fractures due to osteoporosis: a comparison of the OQLQ and QUALEFFO.
abstract: BACKGROUND
  Studies comparing the performance of health-related quality of life instruments in osteoporosis are lacking. We compared the feasibility, validity and reliability of the osteoporosis quality of life questionnaire (OQLQ) and the QUALEFFO (test version) in women with vertebral deformities due to osteoporosis.
  
  
  METHODS
  Three hundred and thirty-eight patients diagnosed with primary osteoporosis and vertebral deformity and a random sample of 304 women from the general population (control group) were recruited. Patients and controls were randomly assigned to receive either the OQLQ or the QUALEFFO, and the SF-36 and EQ-5D. Test-retest reliability was assessed in the patient group.
  
  
  RESULTS
  The QUALEFFO had more items with missing data and took slightly longer to administer (20.7 vs. 18.7 min). Cronbach's alpha and intraclass correlation coefficient (ICC) values for OQLQ domains (alpha: 0.75-0.91; ICC: 0.85-0.93) were slightly higher than for the QUALEFFO (alpha: 0.63-0.90; and ICC: 0.80-0.93). OQLQ and QUALEFFO domain scores correlated as expected with SF-36 and EQ-5D domains. Both questionnaires discriminated between patients and controls though the OQLQ showed slightly better discriminant power.
  
  
  CONCLUSIONS
  The superior performance of the OQLQ in terms of administration time, missing responses, and discriminatory capacity needs to be weighed against the advantages of using a self-administered instrument such as the QUALEFFO. A full comparison also requires data on sensitivity to change.
authors.affiliation: Institut de Salut Pública de Catalunya, Universitat de Barcelona, Barcelona , Spain. xbadia@bell.ub.es
authors.forename: X
authors.initials: X
authors.lastname: Badia
authors.forename: A
authors.initials: A
authors.lastname: Díez-Pérez
authors.forename: C
authors.initials: C
authors.lastname: Alvarez-Sanz
authors.forename: B
authors.initials: B
authors.lastname: Díaz-López
authors.forename: M
authors.initials: M
authors.lastname: Diaz-Curiel
authors.forename: F
authors.initials: F
authors.lastname: Guillén
authors.forename: J
authors.initials: J
authors.lastname: González-Macias
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications; D011788:Quality of Life; D015203:Reproducibility of Results; D013030:Spain; D016103:Spinal Fractures / Q000209:etiology; D011795:Surveys and Questionnaires