title: The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin.
abstract: BACKGROUND
  Several studies implicate polymorphisms in the human beta-adrenergic receptor gene (ADRB2) in the susceptibility to hypertension. We sought to replicate these results in a population of Chinese origin primarily from Taiwan and the San Francisco Bay area.
  
  
  METHODS
  We genotyped >800 hypertensive subjects and individuals with low-normal blood pressure that were derived largely from the same families as the hypertensive patients for three polymorphisms in the ADRB2 gene: a C/T transition at position 47 (C-47T) in the 5' leader cistron; another C/T transition that results in a glycine/ arginine substitution at codon 16 (Gly16Arg), and a G/C transversion that causes a glutamate/glutamine substitution at codon 27 (Glu27Gln).
  
  
  RESULTS
  The Gly16Arg was significantly associated with hypertension (P < .03). Under a dominant model, for hypertension the relative risk for the Gly/Gly and Gly/Arg genotypes versus the Arg/Arg genotype was 1.35 (95% confidence limits [CL] 1.08, 1.70); for low-normal blood pressure the relative risk was 0.79 (95% CL 0.66, 0.94). This polymorphism explained approximately 1% of the variance in systolic and diastolic blood pressures in our study population. There was no evidence of association between the C-47T and Glu27Gln polymorphisms and hypertension in this population.
  
  
  CONCLUSIONS
  The Glyl6 allele in the beta2-adrenergic receptor gene is a susceptibility allele for essential hypertension in a population of Chinese origin.
authors.affiliation: Department of Genetics, Stanford University School of Medicine, California, USA. koustubh.ranade@bms.com
authors.forename: K
authors.initials: K
authors.lastname: Ranade
authors.forename: W H
authors.initials: WH
authors.lastname: Shue
authors.forename: Y J
authors.initials: YJ
authors.lastname: Hung
authors.forename: C A
authors.initials: CA
authors.lastname: Hsuing
authors.forename: F T
authors.initials: FT
authors.lastname: Chiang
authors.forename: R
authors.initials: R
authors.lastname: Pesich
authors.forename: J
authors.initials: J
authors.lastname: Hebert
authors.forename: M
authors.initials: M
authors.lastname: Olivier
authors.forename: Y D
authors.initials: YD
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Pratt
authors.forename: R
authors.initials: R
authors.lastname: Olshen
authors.forename: D
authors.initials: D
authors.lastname: Curb
authors.forename: D
authors.initials: D
authors.lastname: Botstein
authors.forename: N
authors.initials: N
authors.lastname: Risch
authors.forename: D R
authors.initials: DR
authors.lastname: Cox
mesh_terms: D001120:Arginine / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics; D005192:Family Health; D005260:Female; D005838:Genotype; D005998:Glycine / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
chemical_list: D018343:Receptors, Adrenergic, beta-2; D001120:Arginine; D005998:Glycine