[Effect of bailong recipe on proliferation phenotype of human gastric carcinoma BGC82-3 cell line].
OBJECTIVE
To observe the reversive effect of Composite Bailong recipe (BR), a preparation of Chinese herbal medicine, on proliferation phenotype of human gastric carcinoma BGC82-3 cell line.


METHODS
Observation was conducted by using growth curve, colony on soft agar and nude mice oncogenesis experiment.


RESULTS
Growth curve showed the proliferation of BGC82-3 cell was obviously inhibited by BR, the inhibiting rate reached 86% in the 5th day. The colony was few and small on soft agar after treated with BR, only accounted for 52% as compared with that of nontreated. BR obviously inhibited the oncogenesis of BGC82-3 cells in nude mice, the inhibition rate being 50%.


CONCLUSIONS
Composite BR has obvious inhibiting action on malignant proliferation of human gastric BGC82-3 cell line.
Liu
J
J
Key Laboratory of Cell Proliferation and Regulation, Department of Biology, Beijing Normal University, Beijing (100875).
Liu
H
H
Liang
Y
Y
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010641:Phenotype; D013274:Stomach Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal