[Infiltration of monocytes/macrophages and expression of monocyte chemoattractant protein-1 in gingival tissues from patients with rapidly progressive periodontitis].
OBJECTIVE
To find if there was any difference in monocytes/macrophages infiltration and monocyte chemoattractant protein-1(MCP-1) expression between rapidly progressive periodontitis (RPP) and adult periodontitis (AP) tissues.


METHODS
Inflamed gingival specimens (20) were obtained from RPP(14) and AP(6) patients, and specimens from clinically healthy subjects (H,6) as control. The monocytes/macrophages and MCP-1 expression were detected by immuno-histochemistry SP assay with antibodies against CD14 and CD68, and rabbit anti-MCP-1 antibody.


RESULTS
There were no differences in the mean counts (+/- SD) of monocytes/macrophages and MCP-1 positive cells between RPP and AP groups.


CONCLUSIONS
Though rapid and severe periodontal destruction occurs in RPP, there is no differences in monocytes/macrophages infiltration and MCP-1 expression in gingival tissues between rapidly progressive periodontitis and adult periodontitis patients.
Zhu
X
X
School of Stomatology, Beijing Medical University, Beijing 100081.
Meng
H
H
Chen
Z
Z
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D018932:Chemokine CCL2 / Q000096:biosynthesis*; D005891:Gingivitis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D018950:Lipopolysaccharide Receptors / Q000032:analysis; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology; D009000:Monocytes / Q000378:metabolism* / Q000473:pathology; D010518:Periodontitis / Q000378:metabolism* / Q000473:pathology; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D018932:Chemokine CCL2; D018950:Lipopolysaccharide Receptors; C067980:CD68 antigen, human; D000097382:CD68 Molecule