[A generalized chemical-kinetic method for modeling gene networks].
Development of methods for mathematical simulation of biological systems and building specific simulations is an important trend of bioinformatics development. Here we describe the method of generalized chemokinetic simulation generating flexible and adequate simulations of various biological systems. Adequate simulations of complex nonlinear gene networks--control system of cholesterol by synthesis in the cell and erythrocyte differentiation and maturation--are given as the examples. The simulations were expressed in terms of unit processes--biochemical reactions. Optimal sets of parameters were determined and the systems were numerically simulated under various conditions. The simulations allow us to study possible functional conditions of these gene networks, calculate consequences of mutations, and define optimal strategies for their correction including therapeutic ones. Graphical user interface for these simulations is available at http://wwwmgs.bionet.nsc.ru/systems/MGL/GeneNet/.
Likhoshvaĭ
V A
VA
likho@bionet.nsc.ru
Matushkin
Iu G
IuG
Ratushnyĭ
A V
AV
Anan'ko
E A
EA
Ignat'eva
E V
EV
Podkolodnaia
O A
OA
D000465:Algorithms; D002784:Cholesterol / Q000096:biosynthesis; D003196:Computer Graphics; D004171:Diploidy; D004912:Erythrocytes / Q000378:metabolism; D006238:Haploidy; D020407:Internet; D007700:Kinetics; D008957:Models, Genetic
D002784:Cholesterol
Obobshchennyĭ khimiko-kineticheskiĭ metod modelirovaniia gennykh seteĭ.