[Research on the regular pattern of Ag-NOR changes in patients with cancer].
OBJECTIVE
To correlate the relationship between rDNA transcriptional activity of CD4+ helper T cells and immunity in patients with cancer through silver stainability of nucleolus organizing regions (Ag-NORs).


METHODS
The Th(CD4+) rDNA transcriptional activity was compared among patients with cancer, infectious diseases, non-cancerous non-infectious diseases through image analysis.


RESULTS
Th(CD4+) rDNA transcriptional activity was decreased extremely in patients with cancer, but increased in patients with inflammation compared with normal controls.


CONCLUSIONS
The analysis of Th(CD4+) rDNA transcriptional activity may serve as a new tumor marker for tumor diagnosis and differential diagnosis. Therefore, it may provide an innovative and reliable method for clinical cancer diagnosis.
Chen
L
L
Beijing Medical University, Beijing 100083, China.
Wan
Y
Y
Ding
L
L
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004275:DNA, Ribosomal / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000276:immunology*; D009697:Nucleolus Organizer Region / Q000276:immunology*; D016622:Silver Staining; D014158:Transcription, Genetic
D004275:DNA, Ribosomal