[Adaptation to hyperthermia and changes in peripheral blood leukocytes in humans].
Heating humans up to rectal temperature 39.0-39.5 degrees C induces a heat stress and a physiological adaptation. Blood cells were found to produce nitric oxide under these conditions, neutrophiles playing a major role in the process. In our opinion, the HSC 70 takes part in the process of the long cell adaptation augmenting the cells' functional activity. Hyperthermia leads to a massive temporal HSP 72 expression in the blood mononuclears. This expression seems to be due to alterations in the cellular proteins and to oxidative stress.
Andreeva
L I
LI
Russian Military-Medical Academy, St. Petersburg, 194175, Lebedev St., 6, Russia.
Goranchuk
V V
VV
Shustov
E B
EB
Boĭkova
A A
AA
Petrova
V S
VS
Rzhepetskaia
M K
MK
Kuznetsov
V N
VN
Men'shakov
I A
IA
Margulis
B A
BA
Shabanov
P D
PD
D000222:Adaptation, Physiological; D000328:Adult; D001794:Blood Pressure; D001833:Body Temperature Regulation; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006339:Heart Rate; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D007124:Immunoenzyme Techniques; D007376:Interleukin-2 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis; D020033:Protein Isoforms / Q000378:metabolism; D012129:Respiratory Function Tests
D018840:HSP70 Heat-Shock Proteins; D007376:Interleukin-2; D020033:Protein Isoforms; D009569:Nitric Oxide
Adaptatsiia cheloveka k gipertermii i izmeneniia v leĭkotsitakh perifericheskoĭ krovi.