Gene therapy for liver diseases: recent strategies for treatment of viral hepatitis and liver malignancies.
Gene therapy has emerged as a powerful and very plastic tool to regulate biological functions in diseased tissues with application in virtually all medical fields. An increasing number of experimental and clinical studies underline the importance of genes as curative agents in the future. However, intense research is needed to evaluate the potential of gene therapy to improve efficacy and minimise the toxicity of the procedure.
Schmitz
V
V
Gene Therapy Unit, Department of Internal Medicine, Clinica Universitaria, Faculty of Medicine, Universidad de Navarra, Pamplona Spain. Volker.Schmitz@uni-bonn.de
Qian
C
C
Ruiz
J
J
Sangro
B
B
Melero
I
I
Mazzolini
G
G
Narvaiza
I
I
Prieto
J
J
D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000502:physiology; D006525:Hepatitis, Viral, Human / Q000235:genetics / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000628:therapy*