The evolution of the MHC-G gene does not support a functional role for the complete protein.
The study of the MHC-G gene evolution during nearly 40 million years does not support a role for the full molecule. The MHC-G-like proteins of New World monkeys are probably classical presenting molecules. Old World Cercopithecinae monkeys do not have a full MHC-G molecule and human individuals homozygous for the HLA-G null allele are healthy and do not show birth pathologies.
Arnaiz-Villena
A
A
Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain. aarnaiz@eucmax.sim.ucm.es
Martinez-Laso
J
J
Castro
M J
MJ
Morales
P
P
Moscoso
J
J
Varela
P
P
Gomez-Casado
E
E
Allende
L M
LM
D000595:Amino Acid Sequence; D000818:Animals; D002427:Cebidae / Q000235:genetics; D002520:Cercopithecidae / Q000235:genetics; D019143:Evolution, Molecular; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000737:chemistry / Q000502:physiology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I