title: Mitral regurgitation after partial left ventriculectomy as the cause of ventricular redilatation.
abstract: BACKGROUND
  It remains unclear whether ventricular redilatation after partial left ventriculectomy (PLV) is due to underlying pathology or to continued volume overload amenable to surgery.
  
  
  METHODS
  Among patients undergoing PLV, 32 had Doppler echocardiography preoperatively, immediately after surgery (< 1 week), early after surgery (1-3 months), and late after surgery (8-14 months). Patients were divided into groups with mitral regurgitation (MR; MR+, n = 16) and without postoperative MR (MR-, n = 16) and were compared for ventricular size, performance, and survival.
  
  
  RESULTS
  After initial surgical reduction, left ventricular dimension on average gradually increased back to the preoperative level in subgroups of patients with valvular disease and cardiomyopathy and in all patients combined. Most patients showed drastically reduced left ventricular dimension early after PLV. In MR+ patients, dimension increased back to the preoperative level within 3 months after surgery, whereas the MR- group maintained reduced dimension throughout the first year in all patients combined and in a subgroup of patients with cardiomyopathy. Occurrence of significant MR after PLV appeared to be related to severity of fibrosis in excised myocardium but not to severity of preexisting MR, etiology, or performance of mitral valvuloplasty.
  
  
  CONCLUSIONS
  Early postoperative MR, residual or new, appeared to play an important role in dictating early hemodynamics and late outcome in patients undergoing PLV. Results suggest an aggressive simultaneous approach to abolish MR. Causative role of myocardial fibrosis remains unclear and needs further study.
authors.affiliation: Tokai University School of Medicine, Bohseidai, Isehara, Japan. akira@is.icc.u-tokai.ac.jp
authors.forename: A T
authors.initials: AT
authors.lastname: Kawaguchi
authors.forename: L O
authors.initials: LO
authors.lastname: Bocchino
authors.forename: S
authors.initials: S
authors.lastname: Shimura
authors.forename: H L
authors.initials: HL
authors.lastname: Karamanoukian
authors.forename: S
authors.initials: S
authors.lastname: Koide
authors.forename: R J
authors.initials: RJ
authors.lastname: Batista
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D016022:Case-Control Studies; D004108:Dilatation, Pathologic / Q000209:etiology; D018450:Disease Progression; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D012008:Recurrence; D016019:Survival Analysis