A pharmacokinetic-dynamic explanation of the rapid onset-offset of rapacuronium.
The rapid onset and offset of rapacuronium can be explained from its pharmacokinetic and pharmacodynamic characteristics. A unique property of rapacuronium is its high value for ke0, indicating a rapid access to the receptor site. The reason for this high ke0 may be related to the low intrinsic potency of rapacuronium, but this is not yet fully clarified.
Proost
J H
JH
Research Group for Experimental Anaesthesiology and Clinical Pharmacology, Department of Anaesthesiology, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands. j.h.proost@farm.rug.nl
Wright
P M
PM
D006801:Humans; D007442:Intubation, Intratracheal; D007821:Laryngeal Muscles / Q000187:drug effects; D008956:Models, Chemical; D009126:Muscle Relaxation / Q000187:drug effects; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D014673:Vecuronium Bromide / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology*
D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; C082938:rapacuronium