Clinical and genetic analysis of Staphylococcus aureus nasal colonisation and exit-site infection in patients undergoing peritoneal dialysis.
Few data exist regarding the clonal identity of Staphylococcus aureus (SA) that colonises the nostrils and causes exit-site infections in peritoneal dialysis patients. Nasal and exit-site swabs were taken monthly from 41 patients undergoing peritoneal dialysis, and a genetic analysis of SA isolates was performed by pulsed-field-gel electrophoresis. When SA was identified at the exit-site, the clonal identity of nasal and exit-site isolates was demonstrated. In 50% of the SA carriers, nasal isolates were genetically constant over time; in the other 50% a change of colonising SA strains was observed. The risk of exit-site infection was identical in both groups.
Kreft
B
B
Medizinische Klinik I, Medizinische Universität zu Lübeck, Germany. B-Kreft@gmx.de
Eckstein
S
S
Kahl
A
A
Frei
U
U
Witte
W
W
Trautmann
M
M
D000328:Adult; D017677:Age Distribution; D000368:Aged; D002404:Catheterization / Q000009:adverse effects; D016009:Chi-Square Distribution; D015169:Colony Count, Microbial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017817:Nasal Lavage Fluid / Q000382:microbiology*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D017678:Sex Distribution; D013203:Staphylococcal Infections / Q000175:diagnosis*; D013211:Staphylococcus aureus / Q000235:genetics* / Q000302:isolation & purification*