title: [Not Available].
abstract: This review summarizes from biological research in obsessive-compulsive disorder. In particular, functional brain imaging studies investigating the effects of Symptom provocation, of behavioral and pharmacological treatment on brain activity and findings from neurochemical studies are presented with regard to the serotonergic System. We discuss a neurobiological model integrating the findings from brain imaging, functional anatomy and behavioral concepts which favors a functional imbalance within the orbitofrontal - basal ganglia - thalamus ciruit and focus on hypothesis for further research.
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie der Ernst-Moritz-Arndt-Universität Greifswald.
authors.forename: H J
authors.initials: HJ
authors.lastname: Grabe
authors.forename: H J
authors.initials: HJ
authors.lastname: Freyberger
vernacular_title: Neurobiologische Aspekte der Zwangsstörung - Ansätze für eine biologische Psychotherapieverlaufsforschung/ Neurobiological aspects of Obsessive- Compulsive disorder - an Approachfor Biological Research in Psychotherapy.