title: Modulation of membrane traffic by mechanical stimuli.
abstract: All cells experience and respond to mechanical stimuli, such as changes in plasma membrane tension, shear stress, hydrostatic pressure, and compression. This review is an examination of the changes in membrane traffic that occur in response to mechanical forces. The plasma membrane has an associated tension that modulates both exocytosis and endocytosis. As membrane tension increases, exocytosis is stimulated, which acts to decrease membrane tension. In contrast, increased membrane tension slows endocytosis, whereas decreased tension stimulates internalization. In most cases, secretion is stimulated by external mechanical stimuli. However, in some cells mechanical forces block secretion. External stimuli also enhance membrane and fluid endocytosis in several cell types. Transduction of mechanical stimuli into changes in exocytosis/endocytosis may involve the cytoskeleton, stretch-activated channels, integrins, phospholipases, tyrosine kinases, and cAMP.
authors.affiliation: Laboratory of Epithelial Cell Biology, Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. gla6@pitt.edu
authors.forename: Gerard
authors.initials: G
authors.lastname: Apodaca
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D006874:Hydrostatic Pressure; D021381:Protein Transport / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013314:Stress, Mechanical