Molecular diagnosis of inherited neuromuscular disease.
Prevention of inherited disease in companion animals is largely dependent on prebreeding identification of carriers of autosomal recessive disease traits. Molecular diagnosis is emerging as a convenient and reliable method of carrier detection, but few molecular diagnostic tests of inherited neuromuscular disease are readily available. New test development depends on investigations to determine disease genes and the disease causing mutations. A general approach to molecular diagnosis of inherited disorders is discussed.
Fyfe
John C
JC
Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, USA. fyfe@cvm.msu.edu
D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000151:congenital / Q000175:diagnosis* / Q000235:genetics*; D004285:Dogs; D005821:Genetic Techniques / Q000662:veterinary; D009468:Neuromuscular Diseases / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*