Myelination: some receptors required.
Feltri et al. (2001)(this issue) succeed in disrupting beta 1 integrin specifically in Schwann cells, and in so doing, demonstrate that it is required for normal myelination. Their results reveal that signaling by an extracellular matrix receptor plays a key role in the differentiation of myelinating Schwann cells.
Scherer
Steven S
SS
The University of Pennsylvania Medical Center, Philadelphia, PA 19104-6077, USA. sscherer@mail.med.upenn.edu
D000818:Animals; D001369:Axons / Q000378:metabolism; D002454:Cell Differentiation; D017353:Gene Deletion; D006801:Humans; D019012:Integrin beta1 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009186:Myelin Sheath / Q000378:metabolism*; D017474:Receptors, Laminin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism*
D019012:Integrin beta1; D017474:Receptors, Laminin