New possible chelating agents of clinical interest for iron(III): 2-hydroxynicotinic acid and 3-hydroxypicolinic acid. A thermodynamic study.
The formation of complexes between iron(III) and two ligands of possible relevance to chelation therapy, 2-hydroxynicotinic acid and 3-hydroxypicolinic acid, in aqueous 0.6 m (Na)Cl at 25 degrees C, has been investigated by means of potentiometric titrations and UV measurements. In both cases several mononuclear complexes and their deprotonation products are formed.
Di Marco
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VB
Università degli Studi di Padova, Dipartimento di Chimica Inorganica Metallorganica ed Analitica, via Marzolo 1, 35131 Padova, Italy.
Tapparo
A
A
Bombi
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GG
D002614:Chelating Agents / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D007501:Iron / Q000009:adverse effects / Q000737:chemistry*; D008024:Ligands; D009539:Nicotinic Acids / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry*; D013816:Thermodynamics
D002614:Chelating Agents; D005290:Ferric Compounds; D008024:Ligands; D009539:Nicotinic Acids; D010848:Picolinic Acids; C049246:3-hydroxypicolinic acid; D007501:Iron; C011866:2-hydroxynicotinic acid