title: Observations on a new collagen barrier membrane in 16 consecutively treated patients. Clinical and histological findings.
abstract: BACKGROUND
  Space-maintaining capacity, cell disclusive potential, and stability over time are crucial factors to achieving sufficient bone augmentation with membrane barriers. The case series presented here assessed a new collagen barrier used in bone augmentation. Clinically, the healing pattern, especially in cases of secondary healing, was studied.
  
  
  METHODS
  Soft tissue healing was documented by photographs, and the size of the dehiscences calculated by image analysis. The measurements were performed on digitized photographs. During reentry, barrier remnants were dissected and histologically evaluated.
  
  
  RESULTS
  The mean value for dehiscences was 35.5 mm2; all dehiscences healed within 4 weeks after the exposure became evident. The difference was statistically significant between the week 2 and week 6 visits (P = 0.008) for each previously exposed site. The histologic observation of barrier remnants revealed direct apposition of fibrous and bone tissues on the membrane surface.
  
  
  CONCLUSIONS
  In cases of membrane exposure, gingival dehiscences always disappeared in the following weeks without affecting the healing process. Histologic results showed barrier stability over a 6-month period, promoting bone regeneration.
authors.affiliation: Department of Periodontology and Synoptic Dentistry, School of Dentistry, Charitè, Humboldt University Berlin, Germany. anton.friedmann@charite.de
authors.forename: A
authors.initials: A
authors.lastname: Friedmann
authors.forename: F P
authors.initials: FP
authors.lastname: Strietzel
authors.forename: B
authors.initials: B
authors.lastname: Maretzki
authors.forename: S
authors.initials: S
authors.lastname: Pitaru
authors.forename: J P
authors.initials: JP
authors.lastname: Bernimoulin
mesh_terms: D000328:Adult; D000368:Aged; D000539:Alveolar Process / Q000473:pathology; D000540:Alveolar Ridge Augmentation / Q000295:instrumentation / Q000379:methods*; D001706:Biopsy; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use; D003094:Collagen; D003238:Connective Tissue / Q000473:pathology; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D005882:Gingival Diseases / Q000145:classification / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007576:Jaw, Edentulous, Partially / Q000601:surgery; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D010781:Photography; D018709:Statistics, Nonparametric; D013499:Surface Properties; D013524:Surgical Flaps; D013529:Surgical Wound Dehiscence / Q000145:classification / Q000503:physiopathology; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen