title: Effects of ion beam-assisted deposition of hydroxyapatite on the osseointegration of endosseous implants in rabbit tibiae.
abstract: The aim of this study was to evaluate the effects of coating implants with hydroxyapatite (HA) by an ion beam-assisted deposition (IBAD) method and to compare them with implants prepared with sand-blasted and machined surfaces. Examination of osteoblast cultures displayed no difference in the secretion of alkaline phosphatase (ALP) between the various surfaces, but the IBAD-HA specimen showed low ALP secretion (P < .05). Removal torque tests showed that implants coated with HA by the IBAD method had values similar to the implants with a sandblasted surface, but values for the machined-surface implants differed. Implants placed in a group of ovariectomized rabbits showed lower mechanical test values than implants placed in sham-operated rabbits (P < .05). Implants coated with HA by the IBAD method demonstrated the highest mean bone-to-metal contact ratio on all threads and on the 3 best consecutive threads, followed by the implants with a sandblasted surface and implants with a machined surface (P < .05). Hydroxyapatite-coated implants showed a slightly higher bone-to-implant contact ratio than sandblasted implants, but no statistically significant difference was seen between the 2 materials. The implants placed in ovariectomized rabbits showed lower amounts of bone-to-metal contact than the implants placed in sham-operated rabbits, but no statistically significant difference was seen between the 2 groups. Evaluation of bone volume on all threads and the 3 best consecutive threads showed no statistically significant difference among the different surface treatment groups, but lower bone volume was seen in the ovariectomized rabbits than in the sham-operated animals (P < .05).
authors.affiliation: Department of Dentistry, St Vincent's Hospital, School of Medicine, The Catholic University of Korea, Seoul.
authors.forename: Y C
authors.initials: YC
authors.lastname: Jung
authors.forename: C H
authors.initials: CH
authors.lastname: Han
authors.forename: I S
authors.initials: IS
authors.lastname: Lee
authors.forename: H E
authors.initials: HE
authors.lastname: Kim
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis; D000537:Aluminum Oxide; D000818:Animals; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003775:Dental Polishing; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D020007:Implants, Experimental; D007477:Ions; D008422:Materials Testing; D016348:Osseointegration; D010006:Osteoblasts / Q000378:metabolism; D010024:Osteoporosis / Q000503:physiopathology; D010052:Ovariectomy; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia; D014025:Titanium; D019415:Torque
chemical_list: D020099:Coated Materials, Biocompatible; D007477:Ions; D017886:Durapatite; D014025:Titanium; D000469:Alkaline Phosphatase; D000537:Aluminum Oxide