[Different serum lipid adjustment drugs for the treatment of hyperlipidemic fatty liver].
OBJECTIVE
To research the effect of different serum lipid adjustment drugs, Simvastatin and Fenofibrate, on hyperlipidemic fatty liver.


METHODS
The rat models of hyperlipidemic fatty liver induced by high fat diet were treated with Fenofibrate and Simvastatin respectively to investigate the change of the liver index, liver function, the serum and liver lipid, MDA, and pathologic histology.


RESULTS
The liver index and the content of triglyceride (TC1.80 +/-0.20/2.10+/-0.33), total cholesterol (TG 0.76+/-0.18/1.09+/-0.31), MDA both in the serum and the liver in the model group were significantly higher than those in control group. Slight or moderate hepatic steatosis was observed in model group. Fenofibrate decreased serum triglyceride, total cholesterol, and MDA both in serum and liver significantly, but increased the ALT, ALP, liver index, liver lipids, and finally leading to severe hepatic steatosis. Simvastatin lowered the level of lipid and MDA both in serum and liver, and liver histology was improved nearly to normal. Moreover, little side effect on the liver was observed.


CONCLUSIONS
Simvastatin can be applied for prevention and treatment of hyperlipidemic fatty liver safely and effectively, while Fenofibrate can not.
Yan
M
M
Qilu Hospital of Shandong University, Jinan 250012, China.
Lu
R
R
Jia
X
X
Meng
F
F
Zhao
X
X
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D019821:Simvastatin / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D002784:Cholesterol; D019821:Simvastatin