Lack of association between childhood stroke after varicella and human leukocyte antigen (HLA)-B51.
Human leukocyte antigen (HLA)-B51 has been suggested as an immunogenetic marker for a genetic predisposition to vascular occlusion in response to an immunological stimulus. Varicella has been reported to be a possible risk factor for stroke. We performed DNA-based HLA typing in 11 young patients (mean age: 5.2 years) with unexplained ischaemic stroke. In eight of them varicella had occurred before their stroke. HLA-B51 was negative in all 11 patients and we did not find any significant accumulation of other HLA-subgroups. Our study does not support an association between susceptibility to stroke after varicella and HLA-B51.
Kluger
G
G
Neuropediatric Department, BHZ Vogtareuth, Germany. g.kluger@bhz-vogtareuth.de
Hubmann
M
M
Vogler
L
L
Berz
K
K
D002644:Chickenpox / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D012189:Retrospective Studies; D020521:Stroke / Q000276:immunology* / Q000378:metabolism
D006680:HLA Antigens; D011486:Protein C; D017293:Protein S