title: Meta-analysis of multiple myeloma and benzene exposure.
abstract: Epidemiologic studies have suggested that benzene exposure may be a risk factor of multiple myeloma (MM). We performed meta-analyses of case-control studies to assess the association between occupational exposure to benzene and the risk of MM. We divided the occupational sources of benzene exposure into 4 categories, benzene and/or organic solvents, petroleum, petroleum products, and engine exhaust, for conducting the meta-analysis. As a result, a significant positive association was indicated between exposure to engine exhaust and MM (summary odds ratio or summary OR=1.34, 95% confidence interval or 95%CI=1.14-1.57). However, no significant associations were obtained for benzene and/or organic solvents (summary OR=0.74, 95%CI=0.60-0.90), petroleum (summary OR=1.11, 95%CI=0.96-1.28) and petroleum products (summary OR=1.08, 95%CI=0.89-1.33) with risk of MM. These results suggested that benzene exposure itself was not likely to be a risk factor of MM. It is thought that several harmful chemical agents in engine exhaust, other than benzene, could be etiologically related to the risk of MM. Further case-control studies on MM are needed to obtain more information about detailed occupational exposure to toxic substances.
authors.affiliation: Department of Public Health, School of Medicine, Sapporo Medical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sonoda
authors.forename: Y
authors.initials: Y
authors.lastname: Nagata
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: K
authors.initials: K
authors.lastname: Imai
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects; D001554:Benzene / Q000009:adverse effects*; D006801:Humans; D009101:Multiple Myeloma / Q000139:chemically induced* / Q000453:epidemiology; D016273:Occupational Exposure; D012307:Risk Factors
chemical_list: D000395:Air Pollutants, Occupational; D001554:Benzene