title: A new sesquiterpene lactone from Tsoongiodendron odorum Chun.
abstract: A new sesquiterpene lactone (1) was obtained from the cytotoxic fraction of 95% ethanol extract of root barks of Tsoongiodendron odorum Chun together with two known sesquiterpene lactones, costunolide (2) and parthenolide (3). The structure of 1 was elucidated as 5alpha, 6alpha, 7beta, 10beta- 11alpha, 13-dihydro-4(15)-eudesmene-12, 6-olide on the basis of chemical and spectral evidence including X-ray diffraction analysis. Costunolide showed cytotoxic activity against human leukemia (HL-60) cell line. Parthenolide showed promising cytotoxic activities in vitro against HCT-8, Bel-7402, SKOV3, KB, HELA and EJ cell lines. Also, the cytotoxic ethyl acetate fraction of ethanol extract of the root barks from which three chemical components were isolated showed promising cytotoxic activities in vitro against KB, BGC-823, Bel-7402, HCT-8, HL-60 cell lines.
authors.affiliation: Shenyang Pharmaceutical University, China.
authors.forename: X K
authors.initials: XK
authors.lastname: Song
authors.forename: P F
authors.initials: PF
authors.lastname: Tu
authors.forename: L J
authors.initials: LJ
authors.lastname: Wu
authors.forename: Y
authors.initials: Y
authors.lastname: Cai
authors.forename: H
authors.initials: H
authors.lastname: Zhu
authors.forename: Y
authors.initials: Y
authors.lastname: Lu
authors.forename: X Y
authors.initials: XY
authors.lastname: Liu
authors.forename: Q T
authors.initials: QT
authors.lastname: Zheng
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002850:Chromatography, Gel; D018360:Crystallography, X-Ray; D005562:Formazans; D008401:Gas Chromatography-Mass Spectrometry; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D029562:Magnoliaceae / Q000737:chemistry*; D008958:Models, Molecular; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013778:Tetrazolium Salts
chemical_list: C451559:5, 6, 7,10- 11, 13-dihydro-4(15)-eudesmene-12, 6-olide; D000972:Antineoplastic Agents, Phytogenic; D005562:Formazans; D007783:Lactones; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D013729:Terpenes; D013778:Tetrazolium Salts; C079782:MTT formazan; C002669:parthenolide; C002602:costunolide