title: Platelet glycoprotein complex Ia/IIa antibodies cause neonatal alloimmune thrombocytopenia but do not inhibit megakaryopoiesis and platelet recovery after allogeneic cord blood stem cell transplantation.
abstract: A sibling cord blood (CB) transplantation was performed in a boy with Wiskott-Aldrich syndrome. The CB (31 x 10(6) CD34(+) cells) derived from a newborn sister with neonatal alloimmune thrombocytopenia (NAIT) with 40,000 platelets/microl, caused by a maternal anti-HPA-5b and HLA-A2 antibody. Maternal serum did not inhibit clonogenicity after in vitro testing of megakaryopoiesis. Accordingly, this CB was accepted for sibling transplantation. The transplantation showed a good course with fast and sustained hematopoietic reconstitution (granulocytes >500/microl on day +16, platelets >50,000/microl on day +30). This case demonstrates a successful CB transplantation from a donor suffering from NAIT.
authors.affiliation: Department of Transfusion Medicine/Transplantation Immunology, University Hospital Muenster, Muenster, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Cassens
authors.forename: H
authors.initials: H
authors.lastname: Garritsen
authors.forename: R
authors.initials: R
authors.lastname: Kelsch
authors.forename: N
authors.initials: N
authors.lastname: van der Werf
authors.forename: M
authors.initials: M
authors.lastname: Frosch
authors.forename: R
authors.initials: R
authors.lastname: Witteler
authors.forename: W
authors.initials: W
authors.lastname: Ebell
authors.forename: W
authors.initials: W
authors.lastname: Sibrowski
mesh_terms: D015703:Antigens, CD / Q000276:immunology*; D016824:Antigens, Human Platelet / Q000276:immunology*; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D039421:Integrin alpha2; D016023:Integrins / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D009679:Nuclear Family; D038981:Receptors, Collagen; D013921:Thrombocytopenia / Q000097:blood / Q000151:congenital* / Q000276:immunology; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000276:immunology; D014923:Wiskott-Aldrich Syndrome / Q000628:therapy*
chemical_list: C055973:5b alloantigen, human; D015703:Antigens, CD; D016824:Antigens, Human Platelet; D039421:Integrin alpha2; D016023:Integrins; D007518:Isoantibodies; D038981:Receptors, Collagen