Caspase inhibitors block MHV-3 induced apoptosis and enhance viral replication and pathogenicity.
Leibowitz
J L
JL
Department of Pathology and Laboratory Medicine, Texas A&M University System Health Science Center, College Station, Texas 77843-1114, USA.
Belyavskaya
E
E
D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D061945:Caspase Inhibitors; D018352:Coronavirus Infections / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D006524:Hepatitis, Viral, Animal / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D022781:Hepatocytes / Q000821:virology; D008099:Liver / Q000473:pathology; D017737:Macrophages, Peritoneal / Q000821:virology; D051379:Mice; D006517:Murine hepatitis virus / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects*
D000590:Amino Acid Chloromethyl Ketones; D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone