title: Septal stunning by dipyridamole stress shown on quantitative gated perfusion SPECT in a child with hypertrophic cardiomyopathy.
abstract: OBJECTIVE
  Myocardial ischemia is an important problem in hypertrophic cardiomyopathy. Stunning is an important mechanism in progressive dysfunction of the ischemic myocardium. In this report, the authors found prolonged myocardial stunning in a child with hypertrophic cardiomyopathy that was induced by dipyridamole stress on quantitative gated SPECT.
  
  
  METHODS
  A 6-year-old boy with septal hypertrophy underwent rest and dipyridamole stress gated myocardial SPECT. Software was used to quantify automatically segmental perfusion and function at rest and after stress.
  
  
  RESULTS
  Perfusion imaging showed a reversible perfusion decrease in the hypertrophic septum. Cine-gated imaging of the septum showed dyskinesia and a severe abnormality of systolic thickening during the poststress period, whereas it showed nearly complete recovery at rest. Quantified regional perfusion and function indices also showed this perfusion decrease and myocardial dysfunction after dipyridamole stress.
  
  
  CONCLUSIONS
  In a child with hypertrophic cardiomyopathy, myocardial stunning was induced by dipyridamole stress, in accordance with decreased perfusion reserve.
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.
authors.forename: Jin Chul
authors.initials: JC
authors.lastname: Paeng
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
authors.forename: Jeong Seok
authors.initials: JS
authors.lastname: Yeo
authors.forename: Chung Il
authors.initials: CI
authors.lastname: Noh
authors.forename: Yu Kyeong
authors.initials: YK
authors.lastname: Kim
authors.forename: June-Key
authors.initials: JK
authors.lastname: Chung
authors.forename: Myung Chul
authors.initials: MC
authors.lastname: Lee
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging*; D002648:Child; D004176:Dipyridamole; D015637:Gated Blood-Pool Imaging; D006346:Heart Septum; D006801:Humans; D008297:Male; D017682:Myocardial Stunning / Q000000981:diagnostic imaging* / Q000209:etiology; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents
chemical_list: D019275:Radiopharmaceuticals; D014665:Vasodilator Agents; D004176:Dipyridamole; D017256:Technetium Tc 99m Sestamibi