X Chromosomal short tandem repeat polymorphisms near the phosphoglycerate kinase gene in men with chronic prostatitis.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) causes substantial morbidity afflicting approximately 10% of adult males. Treatment is often empirical and ineffective since the etiology is unknown. Other prostate and genitourinary diseases have genetic components suggesting that CP/CPPS may also be influenced by genetic predisposition. We recently reported a highly polymorphic short tandem repeat (STR) locus near the phosphoglycerate kinase gene within Xq11-13. Because this STR is in a region known to predispose towards other prostate diseases, we compared STR polymorphisms in 120 CP/CPPS patients and 300 control blood donors. Nine distinct allele sizes were detected, ranging from 8 to 15 repeats of the tetrameric STR plus a mutant allele (9.5) with a six base deletion in the flanking DNA sequence. The overall allele size distribution in the CP/CPPS patients differed from controls (Chi-square=19.252, df=8, P=0.0231). Frequencies of two specific alleles, 9.5 and 15, differed significantly in CP/CPPS vs. control subjects and allele 10 differed with marginal significance. Alleles 9.5 and 10 were both more common in CP/CPPS patients than controls while allele 15 was less common. These observations suggest that Xq11-13 may contain one or more genetic loci that predispose toward CP/CPPS. Further investigations involving family studies, larger patient populations, and other control groups may help elucidate this potential genetic predisposition in CP/CPPS.
Riley
Donald E
DE
Department of Urology, School of Medicine, University of Washington, Seattle, WA 98195, USA. dri@u.washington.edu
Krieger
John N
JN
D000483:Alleles; D002908:Chronic Disease; D006801:Humans; D008297:Male; D017699:Pelvic Pain / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D010735:Phosphoglycerate Kinase / Q000235:genetics*; D011472:Prostatitis / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D013577:Syndrome; D020080:Tandem Repeat Sequences; D014960:X Chromosome / Q000235:genetics*
D010735:Phosphoglycerate Kinase