title: Aluminium uptake and excretion in potroom workers of a new primary aluminium smelter during the construction stage.
abstract: The aim of this study was to define bio-accumulation and excretion patterns of aluminium in newly employed potroom workers as well as changes in ambient aluminium levels in the potrooms of a modern aluminium smelter during the plant construction stage and one year into full production. A study was carried out on 115 newly employed volunteer potroom workers at various intervals, over a total period of 36 months. Before commencement of employment a structured questionnaire was completed by all study participants and the first collection of blood and urine specimens took place. As none of the subjects had ever worked in the aluminium industry before, they also served as their own controls. Atomic absorption spectroscopy was used to measure the aluminium content in the biological fluids and the content of the metal in the ambient air of the potrooms. Significantly, the study found an early and marked biological response to inhalation of very low levels of airborne aluminium. After only 12 months, the mean concentration of aluminium in serum had almost doubled; thereafter it levelled off. A mixed model analysis did not find any differences in the concentrations of aluminium in the serum of the subjects since the variation between subjects at any given time was much smaller than the variation within subjects. This may be an indication of the pronounced effect of aluminium inhalation on the kinetics of this metal in the human body. Furthermore, urinary excretion of aluminium by the potroom workers showed a linear increase reaching a concentration of only 49 microg l(-1) at the 36 month stage, suggesting a slow rate of elimination.
authors.affiliation: National Centre for Occupational Health, Johannesburg, South Africa. hrollin@mrc.ac.za
authors.forename: H B
authors.initials: HB
authors.lastname: Röllin
authors.forename: P
authors.initials: P
authors.lastname: Theodorou
authors.forename: C M
authors.initials: CM
authors.lastname: Nogueir
authors.forename: J
authors.initials: J
authors.lastname: Levin
mesh_terms: D000328:Adult; D000535:Aluminum / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D007221:Industry; D019570:Inhalation Exposure; D008297:Male; D008669:Metallurgy; D016273:Occupational Exposure; D013054:Spectrophotometry, Atomic; D017132:Workplace
chemical_list: D000535:Aluminum