Influence of host factors on immunoglobulin G concentration in oral fluid specimens.
The influence of host factors (tobacco use, dentition, bleeding gums, oral rinsing, nasal medications, and time since the last meal) on immunoglobulin G (IgG) concentration in oral fluids (OF) was determined by univariate and multivariate analysis. Significant differences in IgG concentration were found to be associated with human immunodeficiency virus (HIV) status (HIV antibody positive, +16.60 microg/ml, P = 0.0001), sex (female, +1.23 microg/ml, P = 0.004), dentition (+2.83 microg/ml, edentulous versus dentulous, P = 0.0001), bleeding gums (+6.35 microg/ml, P = 0.0001), and time since the last meal (+3.55 microg/ml, >6 h, P = 0.0001). These factors could impact diagnostic methods that rely on the immunoglobulin concentration in OF specimens.
Granade
Timothy C
TC
Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road D-12, Atlanta, GA 30333, USA. TGranade@cdc.gov
Phillips
Susan K
SK
Kitson-Piggott
Wendy
W
Gomez
Perry
P
Mahabir
Bisram
B
Oleander
Herbert
H
George
J Richard
JR
Baggs
James
J
Parekh
Bharat
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003817:Dentition; D005260:Female; D015658:HIV Infections / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000276:immunology*; D009067:Mouthwashes; D015999:Multivariate Analysis; D010510:Periodontal Diseases / Q000276:immunology; D012907:Smoking / Q000276:immunology
D007074:Immunoglobulin G; D009067:Mouthwashes