Influence of intraventricular hemorrhage on outcome after rupture of intracranial aneurysm.
This study was performed to analyze the effect of intraventricular hemorrhage (IVH) on 14-day mortality, outcome at 6 months, and the occurrence of chronic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage. Clinical grade of subarachnoid hemorrhage and the distribution of extravasated blood were evaluated in 219 patients with ruptured aneurysms. Computed tomographic scans performed within 72 h of hemorrhage were analyzed to determine the severity of intraventricular and subarachnoid hemorrhage and the volume of intracerebral hematomas. Outcome at 6 months was assessed using the Glasgow Outcome Scale. Intraventricular hemorrhage extension occurred in 109 of the 219 patients studied. Fourteen-day mortality increased from 7.3% in patients without IVH to 14.1% in those with moderate IVH (IVH score 1-6) and to 41.7% in those with more severe IVH (IVH score > 6). The corresponding figures for unfavorable outcome at 6 months are 19.8%, 30.5%, and 66.7%, respectively. According to logistic regression analyses, the severity of IVH was an independent predictor of mortality and functional outcome. The clinical outcome after aneurysm rupture is at least in part determined by the severity of IVH. Knowledge of the effect of IVH may help guide physicians in the care of patients with aneurysmal bleeding.
Mayfrank
L
L
Department of Neurosurgery, Medical Faculty of the University of Technology (RWTH), Aachen, Germany. LMayfrank@post.klinikum.rwth-aachen.de
Hütter
B O
BO
Kohorst
Y
Y
Kreitschmann-Andermahr
I
I
Rohde
V
V
Thron
A
A
Gilsbach
J M
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000150:complications* / Q000401:mortality / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000098:blood supply* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D002532:Intracranial Aneurysm / Q000150:complications* / Q000401:mortality / Q000503:physiopathology*; D020300:Intracranial Hemorrhages / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D013997:Time Factors