title: Increased CSF levels of prostaglandin E(2) in variant Creutzfeldt-Jakob disease.
abstract: The concentration of the cyclooxygenase product prostaglandin E(2) was sixfold higher in CSF samples from 18 cases of variant Creutzfeldt-Jakob disease (CJD) than in a group of eight subjects with other noninflammatory neurologic diseases, and comparable to those found in a group of six patients affected by diseases with a known inflammatory component. This finding suggests that cyclooxygenase activity may have a role in variant CJD pathogenesis, as previously reported in sporadic CJD.
authors.affiliation: Laboratory of Pathophysiology, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Minghetti
authors.forename: F
authors.initials: F
authors.lastname: Cardone
authors.forename: A
authors.initials: A
authors.lastname: Greco
authors.forename: M
authors.initials: M
authors.lastname: Puopolo
authors.forename: G
authors.initials: G
authors.lastname: Levi
authors.forename: A J E
authors.initials: AJ
authors.lastname: Green
authors.forename: R
authors.initials: R
authors.lastname: Knight
authors.forename: M
authors.initials: M
authors.lastname: Pocchiari
mesh_terms: D000328:Adult; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid; D015232:Dinoprostone / Q000134:cerebrospinal fluid*; D006801:Humans; D008875:Middle Aged
chemical_list: C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D015232:Dinoprostone