Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat.
The effects of pinealectomy and exogenous melatonin (N-acetyl-5-methoxytryptamine) on serum leptin levels were investigated in rats. Exogenous administration of melatonin to intact rats resulted in significant decreases in serum leptin levels (P < 0.05) compared to those of the intact control group. Serum leptin levels were significantly elevated in the pinealectomised rats in comparison to the sham-pinealectomised animals (P < 0.001) and were significantly suppressed by exogenous administration of melatonin compared to those of non-treated pinealectomised rats (P < 0.001). Hormone concentrations in the melatonin-treated pinealectomised group were found to be similar to those seen in the sham-pinealectomised group. These results suggest that pineal gland has an effect on leptin release.
Canpolat
S
S
Department of Physiology, Medical School, Firat University, Elazig, Turkey.
Sandal
S
S
Yilmaz
B
B
Yasar
A
A
Kutlu
S
S
Baydas
G
G
Kelestimur
H
H
D000818:Animals; D020738:Leptin / Q000097:blood*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D020738:Leptin; D008550:Melatonin