title: [Cardiac protective effects of tetramethylpyrazine in patients performed open-heart operation with cardiopulmonary bypass].
abstract: OBJECTIVE
  To study the cardiac protective effects of tetramethylpyrazine (TMP) on patients undergoing cardiac operation.
  
  
  METHODS
  Twelve patients with rheumatic heart disease were randomly divided into the TMP group and the control group, 6 in each group. The changes of hemodynamics, serum creatine phosphokinase (CPK), creatine phosphokinase isoenzyme (CPK-MB) levels were observed before, during and 72 hours after operation.
  
  
  RESULTS
  The hemodynamic indexes in the TMP group were better than those in the control group after operation, the serum CPK, CPK-MB levels measuring 12 h, 24 h and 48 h after operation in the TMP group were lower than those in the control group.
  
  
  CONCLUSIONS
  TMP has good cardiac protective function in patients undergoing cardiac operation in improving cardial function and reducing the release of myocardial enzymes.
authors.affiliation: Department of Cardiovascular Surgery, Union Hospital, Tongji Medical University, Wuhan (430022).
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Sun
authors.forename: H
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000328:Adult; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002404:Catheterization; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D011184:Postoperative Period; D011719:Pyrazines / Q000627:therapeutic use*; D012214:Rheumatic Heart Disease / Q000201:enzymology / Q000601:surgery*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D007527:Isoenzymes; D011719:Pyrazines; D014665:Vasodilator Agents; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; C017953:tetramethylpyrazine