Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.
Experiments on rats trained passive avoidance task showed that N-phenyl-acetyl-L-prolyl-glycyl ethyl ester, peptide analog of piracetam (GVS-111, Noopept) after oral administration retained antiamnesic activity previously observed after its parenteral administration. Effective doses were 0.5-10 mg/kg. Experiments on a specially-developed model of active avoidance (massive one-session learning schedule) showed that GVS-111 stimulated one-session learning after single administration, while after repeated administration it increased the number of successful learners among those animals who failed after initial training. In this respect, GVS-111 principally differs from its main metabolite cycloprolylglycine and standard nootropic piracetam.
Ostrovskaya
R U
RU
Institute of Pharmacology, Russian Academy of Medical Science, Moscow. rita_o@postman.ru
Mirsoev
T K
TK
Romanova
G A
GA
Gudasheva
T A
TA
Kravchenko
E V
EV
Trofimov
C C
CC
Voronina
T A
TA
Seredenin
S B
SB
D000284:Administration, Oral; D000818:Animals; D001362:Avoidance Learning; D004151:Dipeptides / Q000008:administration & dosage* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007858:Learning / Q000187:drug effects; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D018697:Nootropic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D011392:Proline / Q000737:chemistry*; D051381:Rats
D004151:Dipeptides; D018696:Neuroprotective Agents; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly; D011392:Proline