Serum soluble interleukin 2 receptor levels and radiological progression in early rheumatoid arthritis.
OBJECTIVE
To investigate the association between serum soluble interleukin 2 receptor (sIL-2R) levels and radiological changes in patients with early rheumatoid arthritis (RA).


METHODS
sIL-2R levels from 155 patients with active RA were measured by immunoassay over a 2 year period and the associations with radiological change and other measures of disease activity were analyzed.


RESULTS
The area under the curve for sIL-2R is weakly associated with the change in the modified Larsen score over a 2 year period; this is weaker than the association of radiological change with serum C-reactive protein.


CONCLUSIONS
We found no significant association of sIL-2R levels with erosive change in early RA.
Camilleri
J P
JP
Rheumatology Department, University Hospital of Wales and School of Medicine, Cardiff, UK. jeremy.camilleri@uhw-tr.wales.nhs.uk
Amos
N
N
Williams
B D
BD
Emery
P
P
Williams
L A
LA
Jessop
J D
JD
D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001175:Arthrography; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D007596:Joints / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012720:Severity of Illness Index
D015415:Biomarkers; D015375:Receptors, Interleukin-2