Gut-acting drugs for lowering cholesterol.
Drugs that indirectly lower blood cholesterol through their actions in the gut have been used for many years. Their utility has been limited by poor tolerability, and hence, poor compliance. New resins are better tolerated and offer an advantage to older drugs. New strategies focusing on reducing serum cholesterol by acting on the gastrointestinal tract may hold even greater promise, combining the safety of nonsystemic agents with the acceptance of statins.
Black
Donald M
DM
Medical Research Laboratories International, 2 Tesseneer Avenue, Highland Heights, KY 41076, USA. Don.Black@mrlinternational.com
D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D002986:Clinical Trials as Topic; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects*
D000924:Anticholesteremic Agents; D002784:Cholesterol