Functional role of auditory cortex in frequency processing and pitch perception.
Microelectrode studies in nonhuman primates and other mammals have demonstrated that many neurons in auditory cortex are excited by pure tone stimulation only when the tone's frequency lies within a narrow range of the audible spectrum. However, the effects of auditory cortex lesions in animals and humans have been interpreted as evidence against the notion that neuronal frequency selectivity is functionally relevant to frequency discrimination. Here we report psychophysical and anatomical evidence in favor of the hypothesis that fine-grained frequency resolution at the perceptual level relies on neuronal frequency selectivity in auditory cortex. An adaptive procedure was used to measure difference thresholds for pure tone frequency discrimination in five humans with focal brain lesions and eight normal controls. Only the patient with bilateral lesions of primary auditory cortex and surrounding areas showed markedly elevated frequency difference thresholds: Weber fractions for frequency direction discrimination ("higher"-"lower" pitch judgments) were about eightfold higher than Weber fractions measured in patients with unilateral lesions of auditory cortex, auditory midbrain, or dorsolateral frontal cortex; Weber fractions for frequency change discrimination ("same"-"different" pitch judgments) were about seven times higher. In contrast, pure-tone detection thresholds, difference thresholds for pure tone duration discrimination centered at 500 ms, difference thresholds for vibrotactile intensity discrimination, and judgments of visual line orientation were within normal limits or only mildly impaired following bilateral auditory cortex lesions. In light of current knowledge about the physiology and anatomy of primate auditory cortex and a review of previous lesion studies, we interpret the present results as evidence that fine-grained frequency processing at the perceptual level relies on the integrity of finely tuned neurons in auditory cortex.
Tramo
Mark Jude
MJ
Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114-2696, USA. MTramo@HMS.Harvard.edu
Shah
Gaurav D
GD
Braida
Louis D
LD
D000161:Acoustic Stimulation; D000222:Adaptation, Physiological; D000328:Adult; D001303:Auditory Cortex / Q000502:physiology / Q000503:physiopathology; D001309:Auditory Threshold; D004056:Differential Threshold / Q000502:physiology; D004569:Electroencephalography; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006225:Hand / Q000294:innervation / Q000502:physiology; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010812:Physical Stimulation; D010897:Pitch Discrimination / Q000502:physiology; D010898:Pitch Perception / Q000502:physiology; D012016:Reference Values; D013017:Sound Localization; D014732:Vibration