Stress management and immune system reconstitution in symptomatic HIV-infected gay men over time: effects on transitional naive T cells (CD4(+)CD45RA(+)CD29(+)).
OBJECTIVE
Changes in immunologic status were evaluated in 25 HIV-infected men randomly assigned to a 10-week stress management intervention or a wait-list control condition.


METHODS
The authors monitored changes in number of transitional naive T cells (CD4(+)CD45RA(+)CD29(+)) over 6-12 months after the completion of the intervention.


RESULTS
Men receiving stress management had higher CD4(+) CD45RA(+)CD29(+) cell counts at follow-up than did the control subjects. This difference was independent of initial number of naive T cells and HIV virus load.


CONCLUSIONS
Stress management is associated with immunologic reconstitution in HIV-positive gay men.
Antoni
Michael H
MH
Department of Psychology, University of Miami, Coral Gables, FL 33124, USA. mantoni@umiami.ir.miami.edu
Cruess
Dean G
DG
Klimas
Nancy
N
Maher
Kevin
K
Cruess
Stacy
S
Kumar
Mahendra
M
Lutgendorf
Susan
S
Ironson
Gail
G
Schneiderman
Neil
N
Fletcher
Mary Ann
MA
D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015928:Cognitive Behavioral Therapy; D005500:Follow-Up Studies; D015658:HIV Infections / Q000276:immunology* / Q000523:psychology / Q000628:therapy; D018451:Homosexuality, Male / Q000523:psychology*; D006801:Humans; D019012:Integrin beta1 / Q000097:blood*; D017493:Leukocyte Common Antigens / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological / Q000150:complications* / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D019562:Viral Load
D019012:Integrin beta1; D017493:Leukocyte Common Antigens