title: [Effects of metformin on hyperinsulinemic anovulation].
abstract: OBJECTIVE
  To investigate the effects of metformin on serum testosterone (T) levels and ovulation in hyperinsulinemic women.
  
  
  METHODS
  Twenty-nine patients with hyperinsulinemic anovulation were treated with metformin for 12 weeks. Among them 19 had history of clomiphene(CC) treatment with 11 cases failure. CC was given again after one month of metformin treatment. Serum T, luteinizing hormone, follicle-stimulating hormone, insulin(Ins) levels were measured after 4 weeks of treatment. Basic body temperature was also observed.
  
  
  RESULTS
  Serum T and Ins levels declined significantly after 4 weeks of metformin treatment [(2.7 +/- 1.6) nmol/L Vs (1.9 +/- 1.0) nmol/L, (49.2 +/- 34.1) mU/L Vs (25.3 +/- 23.9) mU/L, P < 0.05, P < 0.05 respectively]. Eight cases ovulated spontaneously and 8 cases with history of CC failure became ovulatory during CC treatment.
  
  
  CONCLUSIONS
  Metformin is effective for suppressing serum T levels and improving the outcome of ovulation.
authors.affiliation: Department of Gynecology, Shanghai First Maternal and Infant Health Hospital, Shanghai 200040, China.
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Lin
authors.forename: J
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000858:Anovulation / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000503:physiopathology*; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008687:Metformin / Q000494:pharmacology* / Q000627:therapeutic use; D010060:Ovulation / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
chemical_list: D007004:Hypoglycemic Agents; D013739:Testosterone; D008687:Metformin