Review: ligands for receptor tyrosine kinases expressed in the skin as environmental factors for melanocyte development.
Skin is the major tissue where melanocytes develop, and skin keratinocytes provide the necessary micro-environment for melanocyte survival, proliferation, differentiation, and migration. In this paper, we will discuss the ligands for receptor tyrosine kinases produced as environmental cues to support melanocyte development in the skin.
Kunisada
T
T
Department of Hygiene, Gifu University School of Medicine, Japan. tkunisad@cc.gifu-u.ac.jp
Yamazaki
H
H
Hayashi
S I
SI
D000818:Animals; D016922:Cellular Senescence / Q000502:physiology; D019334:Endothelin-3 / Q000502:physiology; D017228:Hepatocyte Growth Factor / Q000502:physiology; D006801:Humans; D008024:Ligands; D008544:Melanocytes / Q000502:physiology*; D008545:Melanoma / Q000503:physiopathology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D012867:Skin / Q000378:metabolism*; D019089:Stem Cell Factor / Q000502:physiology
D019334:Endothelin-3; D008024:Ligands; D019089:Stem Cell Factor; D017228:Hepatocyte Growth Factor; D020794:Receptor Protein-Tyrosine Kinases