title: [Regulation and self-regulation of the pancreas secretion].
abstract: A review of modern experimental and clinical research, including own author's data, on regulation of the periodical and postprandial external pancreas secretion and of the secretion phases. Focus on self-regulation of pancreas exosecretion with the pancreatic enzymes based on the principle of negative feedback, and on mechanisms of the feedback inhibition of pancreatic secretion. Description of the selective and generalised inhibition of secretion of pancreatic enzymes, the role of this mechanism in emergency adaptation of the fermental spectrum of the pancreas secretion in response to the nutritional composition and properties of the duodenal chemus. In conclusion, the experimental and clinical data are presented on use of intraduodenal injection of trypsin as a generalised inhibitor of pancreas secretion in case of acute pancreatitis.
authors.affiliation: Russian Centre of Functional Surgical Gastroenterology, Russian Federation Ministry for Health Care, Krasnodar.
authors.forename: G F
authors.initials: GF
authors.lastname: Korot'ko
authors.forename: S E
authors.initials: SE
authors.lastname: Voskanian
mesh_terms: D000208:Acute Disease; D000818:Animals; D004063:Digestion / Q000502:physiology; D004386:Duodenum / Q000201:enzymology / Q000502:physiology; D025461:Feedback, Physiological; D006801:Humans; D010179:Pancreas / Q000201:enzymology* / Q000378:metabolism*; D010195:Pancreatitis / Q000188:drug therapy; D019518:Postprandial Period; D014357:Trypsin / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D014357:Trypsin
vernacular_title: Reguliatsiia i samoreguliatsiia sekretsii podzheludochnoí zhelezy.