[Relationship between endothelins, nitric oxide and other endothelial active factors and blood stasis syndrome in patients with atherosclerosis obliterans].
OBJECTIVE
To observe the levels of plasma endothelin (ET), nitric oxide (NO), intercellular adhesion molecule (ICAM) and other endothelial active factors, and to investigate the nature of atherosclerosis obliterans (ASO)-blood stasis Syndrome (BSS) from the point of vascular endothelia and molecules.


METHODS
Ninety-eight patients with ASO-BSS were divided into 3 groups (mild, moderate and severe) and 3 clinical Syndrome subtypes (Qi stagnation BSS, Qi deficiency BSS and Damp-Heat BSS). The circulating endothelial count (CEC), ET, NO and other plasma active factors were determined by density gradient method, radioimmunoassay, enzyme immunoassay method.


RESULTS
The patients with ASO-BSS had high CEC and ET levels, low levels of NO, and had alterations of hemorheology, particularly in those with severe BSS and Damp-Heat BSS.


CONCLUSIONS
ASO-BSS patients have endothelial injuries, endothelial dysfunction, and alterations of hemorheology, which may be the pathogenetic mechanism of ASO-BSS. Observation on these parameter changes will be helpful to evaluate severity, to distinguish the clinical types in TCM, and to clarify the nature of BSS.
Wang
C
C
General Hospital of Tianjin Medical University, Tianjin (300052).
Qi
Q
Q
Wu
X
X
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001162:Arteriosclerosis Obliterans / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood; D003937:Diagnosis, Differential; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*
D015815:Cell Adhesion Molecules; D016232:Endothelins; D009569:Nitric Oxide