[Influence of interferon-alpha therapy on the count and function of T lymphocytes in children with chronic hepatitis C].
This study aims to assess number and function of T lymphocytes in children with chronic hepatitis persistent C. The study included 60 children with chronic hepatitis C. Among this group 30 were treated with interferon-alpha (INF-alpha) during 6 months. Forty healthy children were included in the study as the control group. We examined subsets of blood lymphocytes T (CD3, CD4, CD8) and lymphocytes with expression of CD3/HLADR, CD3/CD25 antigens using monoclonal antibodies IMK plus and flow cytometry, at the beginning and after 6 months. After INF-alpha therapy a significant increase in subset of CD4 lymphocytes, significant decrease in CD8, increase in CD4/CD8 ratio and increase in lymphocytes with expression CD3/HLADR, CD3/CD25 receptors were observed. Differences in CD8 lymphocytes and CD4/CD8 ratio in the treated children were statistical higher in children with elimination HCV RNA. Applying INF-alpha in children with chronic hepatitis C stimulated immunological response by increasing subsets of CD4 lymphocytes, CD4/CD8 ratio and stimulated lymphocytes.
Woźniakowska-Gesicka
T
T
III Klinika Pediatrii Instytutu Centrum Zdrowia Matki Polki w Łodzi.
Wiśniewska-Ligier
M
M
Kupś
J
J
Borowska-Rybus
B
B
Sułat-Syncerek
D
D
Grzegorczyk
W
W
D015703:Antigens, CD / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use*; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007223:Infant; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
D015703:Antigens, CD; D000998:Antiviral Agents; D016898:Interferon-alpha
Wpływ leczenia interferonem-alpha na liczbe i funkcje limfocytów T u dzieci chorych na przewlekłe zapalenie watroby typu C.