Effect of amylin on the tone of rat aorta ring preparation.
Amylin (10(-10)M) induced relaxation of norepinephrine-precontracted rat aortic rings by more than 50%. This effect was preserved after blockade of NO-synthase and even after denudation of the vessel. Thus amylin-induced vasodilation is an endothelium-independent process not mediated by NO.
Luk'yantseva
G V
GV
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
Sergeev
I Y
IY
Kopylova
G N
GN
Samonina
G E
GE
German
S V
SV
D000109:Acetylcholine / Q000494:pharmacology; D000682:Amyloid / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D008297:Male; D009130:Muscle, Smooth / Q000166:cytology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D019001:Nitric Oxide Synthase; D000109:Acetylcholine; D009638:Norepinephrine