[Effect of kidney-replenishing herbs on ovarian function of dexamethasone-induced osteoporosis in rats].
OBJECTIVE
To investigate the effect of Kidney-replenishing herbs (KRH) on ovarian function of experimental rats with dexamethasone-induced osteoporosis (OP).


METHODS
Radioimmunoassay was used to analyse blood level of growth hormone (GH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P), testosterone (T) and prolactin (PRL) of animals and data of three groups, the normal control group, the pathologic control group (non-treated OP model) and the treated group (model rats treated with KRH) were compared. Weight and histomorphological features of ovary and uterus of the rats were also observed.


RESULTS
As compared with the normal control group, levels of GH, LH, FSH, E2 and P in the pathologic control group were significantly lowered (P < 0.05), and the weight of ovary and uterus decreased (P < 0.05). In comparison of the treated group and the pathologic group, GH, LH, FSH, E2 and P levels were significantly higher and weight of ovary and uterus heavier in the treated group (P < 0.05). No obvious changes occurred in T and PRL levels. KRH showed markedly improving effect on the ovarian and uterine morphological construction of rats.


CONCLUSIONS
KRH could elevate the level of GH, LH, FSH, E2 and P, increase the weight and improve the histomorphologic features of ovary and uterus in OP rats, it demonstrated that KRH has therapeutic effect in treating dexamethasone-induced OP rats.
An
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Department of TCM-WM Basic Theory, Hebei Medical University, Shijiazhuang (050017).
Li
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E
Zhao
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J
D000818:Animals; D003907:Dexamethasone; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D010024:Osteoporosis / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D010053:Ovary / Q000503:physiopathology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D004958:Estradiol; D003907:Dexamethasone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone