Cytochrome P450 database.
This paper describes a specialized database dedicated exclusively to the cytochrome P450 superfamily. The system provides the impression of superfamily's nomenclature and describes structure and function of different P450 enzymes. Information on P450-catalyzed reactions, substrate preferences, peculiarities of induction and inhibition is available through the database management system. Also the source genes and appropriate translated proteins can be retrieved together with corresponding literature references. Developed programming solution provides the flexible interface for browsing, searching, grouping and reporting the information. Local version of database manager and required data files are distributed on a compact disk. Besides, there is a network version of the software available on Internet. The network version implies the original mechanism, which is useful for the permanent online extension of the data scope.
Lisitsa
A V
AV
Institute of Biomedical Chemistry, Pogodinskaya, 10, 119832 Moscow, Russia. fox@ibmh.msk.su
Gusev
S A
SA
Karuzina
I I
II
Archakov
A I
AI
Koymans
L
L
D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000494:pharmacology*; D016208:Databases, Factual; D006801:Humans; D019451:Information Management; D020407:Internet; D012984:Software; D013329:Structure-Activity Relationship
D003577:Cytochrome P-450 Enzyme System