[Implication and mode of action of infectious agents in the formation of atheromatous plaques. Infection and atherosclerosis].
Different kinds of infectious agents seem to be implied in the atherosclerotic process. Indeed, some bacteria and viruses have been identified in atherosclerotic lesions: Chlamydia pneumoniae, Helicobacter pylori, Streptococcus sanguis, Porphyromonas gingivalis, herpes simplex viruses type 1 and 2, coxsakievirus B and hepatitis virus A. By their ability to induce antigenic and functional changes in the cells of the vascular wall (endothelial cells, smooth muscle cells, monocytes/macrophages, and fibroblasts) and to stimulate immune response as well as oxidative stress, it is more and more tempting to speculate that infectious agents probably play key roles in the initiation and in the formation of atherosclerotic plaques in certain patients.
Lizard
G
G
Laboratoire de biochimie médicale, Inserm U 498, CHU hôpital du Bocage, BP 1542, 21034 Dijon, France. Gerard.Lizard@u-bourgogne.fr
Gambert
P
P
D001161:Arteriosclerosis / Q000382:microbiology* / Q000821:virology*; D001424:Bacterial Infections / Q000382:microbiology; D002689:Chlamydia; D003587:Cytomegalovirus; D016480:Helicobacter pylori; D030041:Hepatitis A virus; D006801:Humans; D016966:Porphyromonas gingivalis; D018139:Simplexvirus; D013298:Streptococcus sanguis; D014777:Virus Diseases / Q000821:virology
Implication et modes d'action des agents infectieux dans la formation de la plaque d'athérome. Infection et athérosclérose.