Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux) technology.
Lin
W
W
Biological Sciences, ALZA Corporation, Mountain View, California 94043, USA. weiqi.lin@alza.com
Cormier
M
M
Samiee
A
A
Griffin
A
A
Johnson
B
B
Teng
C L
CL
Hardee
G E
GE
Daddona
P E
PE
D000279:Administration, Cutaneous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems / Q000379:methods*; D006168:Guinea Pigs; D007478:Iontophoresis; D008099:Liver / Q000737:chemistry; D008845:Microinjections / Q000379:methods*; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012867:Skin / Q000737:chemistry; D013997:Time Factors
D016376:Oligonucleotides, Antisense