[Experimental study of parotid gland injected with gentian violet].
OBJECTIVE
The Gentian Violet was used for treating the chronic parotitis since 1960's, but the dosage and the histologic changes of the tissues were undefined until now. We try to study the histologic changes of the salivary glands, heart, liver and kidneys after large volume of gentian violet was injected into the parotid gland through the duct.


METHODS
5 ml of Gentian Violet was injected to each side of 6 dogs. The macropathologic and histologic examination of the salivary glands, heart, liver and kidneys were performed at 30 min, 60 min, 120 min, 21 days and 9 months separately after the perfusion.


RESULTS
Local swelling was obvious in two or three days after infusion and subsided in one week in most of the dogs. Degeneration of the gland took place after 20 days. After 9 months, the parotid gland tissues were replaced by the connective tissues. On the other hand, no histologic change was observed in heart, liver and kidney in the investigation.


CONCLUSIONS
The Gentian Violet can cause degeneration of the parotid gland including the duct and replaced by connective tissues later. There is no obvious changes were noted in other organs.
Zhang
G
G
School of Stomatology, Beijing Medical University, Beijing 100081.
Zhang
Z
Z
Zou
Z
Z
D000818:Animals; D004285:Dogs; D005840:Gentian Violet / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D010306:Parotid Gland / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D005840:Gentian Violet