[Clinical study on therapeutic mechanism of Sini Decoction in treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCM].
OBJECTIVE
To study the mechanism of Sini Decoction (SND) in prevention and treatment of post-percutaneous transluminal coronary angioplasty (PTCA) ischemia-reperfusion injury with different Syndrome typing of TCM.


METHODS
Forty patients received PTCA were randomly divided equally into the SND group and the control group, in each group, there were 10 of Excess Syndrome (ES) and 10 of Deficiency Syndrome (DS). Twenty-five ml of SND was given daily to the SND group from 3 days before operation to the third day after operation. The blood superoxide dismutase (SOD) activity, malondialdehyde (MDA) and nitric oxide (NO) content of patients were determined before PTCA, and 1 hrs, 12 hrs, 24 hrs, 48 hrs and 72 hrs after PTCA.


RESULTS
Before PTCA, the cases of DS were characterized by low SOD activity and high MDA content, as compared with the patients of ES, P < 0.05. SND could relieve the post-PTCA deprivation of SOD activity and NO content and the elevation of MDA level of both ES and DS patients, the amplitude of elevation of SOD activity in DS patients was higher than that in ES patients (P < 0.05).


CONCLUSIONS
SND has antagonisting effect on post-PTCA ischemia-reperfusion injury, which is more effective in treating patients with DS.
Wu
W
W
Institute of Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou (510089).
Su
J
J
Lin
S
S
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D003327:Coronary Disease / Q000097:blood / Q000628:therapy*; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D013482:Superoxide Dismutase