title: [Analysis of polymorphic variants of renin-angiotensin system genes in polymetabolic syndrome and non-insulin-dependent diabetes].
abstract: Polymorphisms of the genes for angiotensin-converting enzyme (ACE) and angiotensinogen, the proteins of the renin-angiotensin system (RAS), were tested for association with the polymetabolic syndrome (PMS) and non-insulin-dependent diabetes mellitus (NIDDM) in the Moscow population. The insertional (I) allele and genotype II of the ACE gene proved to be associated with PMS. A significant difference in allele and genotype frequency distributions of the (CA)n microsatellite of the 3'-untranslated exon of the angiotensinogen gene was revealed between randomly sampled individuals and patients with PMS and IDDM from the Moscow population.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Miloserdova
authors.forename: N V
authors.initials: NV
authors.lastname: Perova
authors.forename: M I
authors.initials: MI
authors.lastname: Balabolkin
authors.forename: P A
authors.initials: PA
authors.lastname: Slominskiĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Limborskaia
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D009031:Moscow; D016254:Mutagenesis, Insertional; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions
vernacular_title: Analiz polimorfnykh variantov genov renin-angiotenzinovoĭ sistemy pri polimetabolicheskom sindrome i insulin-nezavisimom sakharnom diabete.