title: Dopamine system stabilizers, aripiprazole, and the next generation of antipsychotics, part 1, "Goldilocks" actions at dopamine receptors.
abstract: Dopamine system stabilizers are a potential new class of antipsychotic agents without motor side effects. All known effective antipsychotics act at D2 receptors. A novel concept for an antipsychotic without motor side effects is to stabilize these receptors rather than block them harshly.
authors.affiliation: Neuroscience Education Institute in Carlsbad, Calif 92009, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Stahl
mesh_terms: D014150:Antipsychotic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D000068180:Aripiprazole; D001665:Binding Sites / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D015259:Dopamine Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D010879:Piperazines / Q000493:pharmacokinetics / Q000494:pharmacology*; D011618:Psychotic Disorders / Q000188:drug therapy*; D015363:Quinolones / Q000493:pharmacokinetics / Q000494:pharmacology*; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000378:metabolism; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D015259:Dopamine Agents; D010879:Piperazines; D015363:Quinolones; D017448:Receptors, Dopamine D2; D000068180:Aripiprazole