Characteristics of c-fos gene expression in the brains of rats with different investigative and defensive behaviors.
Differences were found in the expression of the c-fos gene in brain structures of rats with "active" and "passive" types of behavior in the open field, hole exploration, and step-down tests. The most marked and intense expression of the c-fos gene was seen in "passive" rats. After electrocutaneous stimulation in the step-down test, these animals showed maximum expression of the c-fos gene in most areas of the cerebral cortex, the amygdala, in olfactory structures, the hypothalamus, and the brainstem. In "active" rats in the same conditions, expression of the c-fos gene was seen only in the infralimbic cortex and olfactory nuclei. These results, along with existing data on neurological mapping of the c-fos gene, demonstrate a relationship between the level and topography of c-fos expression, and with typological and, perhaps, individual characteristics of rats.
Babai
P
P
P. K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Sciences, Moscow.
Anokhin
K V
KV
Dolgov
N
N
Sudakov
K V
KV
D000374:Aggression / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry / Q000235:genetics* / Q000502:physiology*; D001931:Brain Mapping; D003216:Conditioning, Operant / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D016762:Genes, fos / Q000235:genetics*; D007150:Immunohistochemistry; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
D012333:RNA, Messenger