title: Periodontal response to two intracanal medicaments in replanted monkey incisors.
abstract: Intracanal medicaments are recommended for use in replanted teeth to inhibit inflammatory root resorption. This study compared the effect of calcium hydroxide (Pulpdent) and a corticosteroid-antibiotic paste (Ledermix) on periodontal healing and root resorption following replantation. Incisors of eight Macaca fascicularis monkeys were extracted, stored dry for 15 min and replanted. After 11 days, root canals in two adjacent maxillary incisors were treated with one medicament and contralateral incisors with the other medicament, or left as untreated controls. Animals were sacrificed 8 weeks later and the teeth prepared for histomorphometric evaluation of periodontal ligament inflammation and root resorption. Periodontal ligament inflammation and inflammatory root resorption were markedly inhibited by both calcium hydroxide and corticosteroid-antibiotic relative to untreated controls. Replacement resorption was lowest in the corticosteroid-antibiotic group, and significantly (P<0.05) more normal periodontal ligament was present in this group (79.6%) than in calcium hydroxide and control groups (64.6% and 62.7%, respectively). Treatment with the corticosteroid-antibiotic inhibited inflammatory resorption and was slightly more effective than calcium hydroxide in producing a periodontal healing response.
authors.affiliation: Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Y L
authors.initials: YL
authors.lastname: Thong
authors.forename: H H
authors.initials: HH
authors.lastname: Messer
authors.forename: C H
authors.initials: CH
authors.lastname: Siar
authors.forename: L H
authors.initials: LH
authors.lastname: Saw
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002126:Calcium Hydroxide / Q000627:therapeutic use; D003707:Demeclocycline / Q000627:therapeutic use; D003739:Dental Cementum / Q000187:drug effects / Q000473:pathology; D003804:Dentin / Q000187:drug effects / Q000473:pathology; D004338:Drug Combinations; D007180:Incisor / Q000293:injuries*; D008252:Macaca fascicularis; D010513:Periodontal Ligament / Q000187:drug effects* / Q000473:pathology; D010518:Periodontitis / Q000473:pathology / Q000517:prevention & control; D012388:Root Canal Irrigants / Q000627:therapeutic use*; D012391:Root Resorption / Q000473:pathology / Q000517:prevention & control; D018709:Statistics, Nonparametric; D014084:Tooth Avulsion / Q000628:therapy*; D014090:Tooth Replantation; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology; D014222:Triamcinolone Acetonide / Q000627:therapeutic use; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D012388:Root Canal Irrigants; C029777:Pulpdent; D003707:Demeclocycline; C001527:Ledermix; D014222:Triamcinolone Acetonide; D002126:Calcium Hydroxide