[Correlation between cell-functional differentiation phenotype and pathobiological behavior of gastric carcinoma].
OBJECTIVE
To demonstrate the correlation between cell-functional differentiation features and invasion, metastasis of gastric carcinoma (GC) by establishing a new classification based on cell-functional differentiation.


METHODS
According to the direction and condition of cell-functional differentiation, 361 gastric carcinomas were divided into five types to show their respective pathobiological behavior.


RESULTS
(1) Absorptive functional differentiation type (AFDT): 22.7%(82). 13.6% of the male patients developed liver metastasis, (2) Mucin-secreting functional differentiation type (MSFDT): 15%(54). 98.1% of GC showed serosa invasion, (3) Absorptive and mucin-producing double functional differentiation type (AMPFDT): 49.9% (180). Women infliction (34.4%) and estrogen receptor (ER) expression (71.7%) in this group were more common than in the other types (P < 0.01). 19.4% of these female patients were complicated with ovarian metastasis, (4) Specific functional differentiation type (SFDT): 3.6%(13). 69.2% of these tumors derived from (high) A (amine content) + (high) P (precursor) U (uptake from the ambient medium) + (presence of) D (decarboxylase) (APUD) system and (5) non-functional differentiation type (NFDT): 8.9%(32). 59.4% developed lymphatic metastasis. The 5-year survival rates of these types were 58.5%, 28.6%, 24.7%, 60.0% and 28.1%, respectively.


CONCLUSIONS
This new cell-functional classification of gastric cancer is helpful by indicating their pathobiological behavior and characteristics of invasion and metastasis. Further study is needed to clarify the correlation between cell-functional differentiation phenotypes and their relevant genotypes as well as the inherent relationship between the biological behavior.
Xin
Y
Y
Fourth Laboratory, Cancer Institute, China Medical University, Shenyang 110001, China.
Li
X
X
Wang
Y
Y
D002454:Cell Differentiation; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009077:Mucins / Q000378:metabolism; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000556:secondary; D011960:Receptors, Estrogen / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis; D015996:Survival Rate
D009077:Mucins; D011960:Receptors, Estrogen