Cloning of rat calcium-modulating cyclophilin ligand.
Rat calcium-modulating cyclophilin ligand (CAML) cDNA was cloned and sequenced. It has a predicted open reading frame of 294 amino acids. The CAML gene is highly conserved throughout species, showing 85, 89 and 69% amino acid sequence identity to the human, mouse, and chicken genes, respectively. Gene expression data using astrocytes, microglia and neurons show that CAML mRNA and protein is constitutively expressed in these cell types of the central nervous system. The cloning of rat CAML will facilitate further investigations on the function of this molecule.
Lee
S J
SJ
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Drabik
K
K
Benveniste
E N
EN
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D003001:Cloning, Molecular; D021983:Cyclophilins / Q000378:metabolism; D008024:Ligands; D008969:Molecular Sequence Data; D051381:Rats / Q000235:genetics*; D016415:Sequence Alignment; D020798:Two-Hybrid System Techniques
D048868:Adaptor Proteins, Signal Transducing; C490314:Caml protein, mouse; C490313:Camlg protein, rat; D002352:Carrier Proteins; D008024:Ligands; D021983:Cyclophilins; D002118:Calcium