A comparison between 50 mcg oral misoprostol every 4 hours and 6 hours for labor induction: a prospective randomized controlled trial.
OBJECTIVE
To compare the effectiveness and safety between 50 mcg oral misoprostol every 4 hours and 6 hours for labor induction.


METHODS
A prospective randomized controlled trial.


METHODS
Department of Obstetrics & Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.


METHODS
Eighty nine pregnant women of at least 34 weeks' gestation with indications for labor induction in the condition of unfavourable cervix (Bishop score < or = 4) and no contraindication to prostaglandin therapy.


METHODS
All pregnant women were randomized to receive either 50 mcg misoprostol orally every 4 hours or 6 hours.


METHODS
Treatment interval from induction to vaginal delivery, maternal and neonatal complication.


RESULTS
The mean treatment intervals from induction to vaginal delivery were 22.10 +/- 18.49 hours and 20.91 +/- 11.98 hours in the misoprostol group every 4 hours and 6 hours, respectively. The treatment intervals between the two groups were not statistically significant. There was also no significant difference between both groups with regard to maternal and neonatal complications.


CONCLUSIONS
The effectiveness in terms of treatment interval from induction to vaginal delivery were comparable between the two groups, but administration of misoprostol every 6 hours was found to have a slightly shorter interval, although it did not reach statistical significance. No serious maternal and neonatal complication was demonstrated in both groups. Either regimen in this study can be an alternative for labor induction.
Pongsatha
S
S
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.
Tongsong
T
T
Somsak
T
T
D000284:Administration, Oral; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007751:Labor, Induced; D016595:Misoprostol / Q000008:administration & dosage*; D010120:Oxytocics / Q000008:administration & dosage*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies
D010120:Oxytocics; D016595:Misoprostol