title: Adolescent Caucasian mothers have reduced adult hip bone density.
abstract: OBJECTIVE
  To determine the long-term effect of full term teen pregnancy on peak hip bone mineral density.
  
  
  METHODS
  Longitudinal observational study.
  
  
  METHODS
  Academic clinical research center.
  
  
  METHODS
  Sixteen non-Hispanic white females: 4 cases and 12 matched controls who are part of The Penn State Young Women's Health Study and have been studied from ages 12 to 21.
  
  
  METHODS
  Four of the subjects had uncomplicated full-term pregnancies between ages 16.5 and 19.5 years.
  
  
  METHODS
  The cases and controls were matched for body mass index at age 12 years, total body bone mineral content at age 12 years, age of menarche, and sports-exercise score during ages 12-18 years. They were then compared with respect to bone measures, cardiovascular disease risk factors, and endocrine profiles at ages 19-21 years.
  
  
  RESULTS
  The four teen mothers had significantly lower adult hip bone mineral density than did the controls (0.89 g/cm(2) vs. 0.99 g/cm(2); P=.03). The reproductive hormone patterns of the cases were not statistically significantly different from those of the controls, yet the cases showed a postmenopausal blood lipid pattern.
  
  
  CONCLUSIONS
  The persistent reduction in hip bone mineral density of the cases is consistent with significantly increased risk of future hip fracture.
authors.affiliation: Department of Health Evaluation Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA. tal3@psu.edu
authors.forename: Tom
authors.initials: T
authors.lastname: Lloyd
authors.forename: Hung Mo
authors.initials: HM
authors.lastname: Lin
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Eggli
authors.forename: William C
authors.initials: WC
authors.lastname: Dodson
authors.forename: Laurence M
authors.initials: LM
authors.lastname: Demers
authors.forename: Richard S
authors.initials: RS
authors.lastname: Legro
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001823:Body Composition; D015992:Body Mass Index; D015519:Bone Density; D002648:Child; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000453:epidemiology; D004958:Estradiol / Q000097:blood; D015444:Exercise; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D009035:Mothers; D010384:Pelvic Bones / Q000033:anatomy & histology*; D010414:Pennsylvania; D011247:Pregnancy; D011253:Pregnancy in Adolescence / Q000502:physiology*; D012016:Reference Values; D012307:Risk Factors; D013177:Sports; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood; D044465:White People
chemical_list: D014280:Triglycerides; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002784:Cholesterol