Kynurenine and its metabolites in the rat with experimental renal insufficiency.
In uremia a great number of the endogenous metabolites that are ordinarily excreted in urine accumulate in the blood. Among these are the products of KYN degradation. In the present study we evaluated the peripheral KYN metabolism in the various stages of the rat experimental chronic renal insufficiency. Our results showed significant disturbances in peripheral kynurenic pathway, which resulted in the significant decrease of TRP plasma level and augmentation of concentration of its metabolites. The high concentrations of 3-hydroxykynurenine, xanthurenic acid, kynurenic acid, anthranilic acid and quinolinic acid positively correlated with degree of the renal insufficiency. Talking into account the biological properties of KYN metabolites, their accumulation in the blood, may be at least partially, responsible for severity of uremia as well as for uremic symptoms such as neuropathy, increased susceptibility to infections, hypertension, lipid disturbances and anemia.
Pawlak
D
D
Department of Pharmacodynamics, Medical Academy, Bialystok, Poland. dariuszpawlak@poczta.onet.pl
Tankiewicz
A
A
Buczko
W
W
D000818:Animals; D004326:Drinking; D004435:Eating; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007737:Kynurenine / Q000378:metabolism*; D008297:Male; D017378:Quinolinic Acid / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014364:Tryptophan / Q000378:metabolism
D007737:Kynurenine; D014364:Tryptophan; D017378:Quinolinic Acid