Translocation of proteins into mitochondria.
The translocase of the outer mitochondrial membrane (TOM) is composed of receptors, a channel protein, and its modulators that function together to import proteins into mitochondria. Although the import pathway of proteins directed to the mitochondrial matrix has been well characterized, recent studies into the import pathway taken by proteins into the other submitochondrial compartments have broadened our understanding into the way the TOM machinery recognizes, interacts, and translocates proteins.
Hoogenraad
N J
NJ
Department of Biochemistry, La Trobe University, Melbourne, Australia. N.Hoogenraad@latrobe.edu.au
Ryan
M T
MT
D000818:Animals; D001665:Binding Sites; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D011498:Protein Precursors / Q000737:chemistry / Q000378:metabolism; D021382:Protein Sorting Signals; D021381:Protein Transport; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D015003:Yeasts / Q000378:metabolism
D002352:Carrier Proteins; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011498:Protein Precursors; D021382:Protein Sorting Signals; D018160:Receptors, Cytoplasmic and Nuclear