title: Screening of antimicrobial activities in red, green and brown macroalgae from Gran Canaria (Canary Islands, Spain).
abstract: Extracts from 44 species of seaweed from Gran Canaria (Canary Islands, Spain) were screened for the production of antibacterial and antifungal compounds against a panel of gram-negative and gram-positive bacteria, mycobacteria, yeasts and fungi. A total of 28 species displayed antibacterial activity, of which six also showed antifungal activity. Asparagopsis taxiformis and Cymopolia barbata were the species with the strongest activities against the broadest spectrum of target microorganisms. All the species with antibacterial activity were active against gram-positive bacteria, whereas only two species, A. taxiformis and Osmundea hybrida, were active against mycobacteria. The production of secondary metabolites with antimicrobial activities by the macroalgae was also studied under different conditions, although no common trend for bioactivity was observed.
authors.affiliation: Center for Basic Research, Merck Research Laboratories, Merck Sharp & Dohme de España, Madrid. ant_gonzalez@merck.com
authors.forename: A
authors.initials: A
authors.lastname: González del Val
authors.forename: G
authors.initials: G
authors.lastname: Platas
authors.forename: A
authors.initials: A
authors.lastname: Basilio
authors.forename: A
authors.initials: A
authors.lastname: Cabello
authors.forename: J
authors.initials: J
authors.lastname: Gorrochategui
authors.forename: I
authors.initials: I
authors.lastname: Suay
authors.forename: F
authors.initials: F
authors.lastname: Vicente
authors.forename: E
authors.initials: E
authors.lastname: Portillo
authors.forename: M
authors.initials: M
authors.lastname: Jiménez del Río
authors.forename: G G
authors.initials: GG
authors.lastname: Reina
authors.forename: F
authors.initials: F
authors.lastname: Peláez
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019149:Bioreactors; D004352:Drug Resistance, Microbial; D012624:Seaweed / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D013030:Spain
chemical_list: D000900:Anti-Bacterial Agents