[Primary drug-resistance of Mycobacterium tuberculosis in Shanghai, 1985-1995].
OBJECTIVE
To evaluate the problem of antituberculosis drug resistance in Shanghai, 1985-1995.


METHODS
All of the strains of M. tuberculosis from new patients with pulmonary tuberculosis were tested for resistance to INH, RFP, EMB, SM, PAS, and KM by the absolute concentration method on Lowenstein-Jensen medium.


RESULTS
The rates of primary drug resistance to SM, INH, RFP, PAS, and KM were 10.2%, 5.2%, 4.8%, 5.6%, and 3.9% respectively in 1985, and decreased to 4.8%, 4.8%, 4.3%, 3.6%, and 2.6% in 1995, while the rate of drug resistance to EMB was 1.3% in 1985, and increased to 3.3% in 1995. The primary resistance rate to one or more drugs was 15.6% in 1985 and 8.2% in 1995. The resistance rates to one, two, three, four, five, and six drugs were 5.9%, 4.6%, 2.5%, 1.5%, 0.4%, and 0.8% respectively in 1985, and decreased to 1.9%, 3.5%, 1.2%, 1.2%, 0.1%, and 0.4% in 1995. The resistance rates to INH and RFP were 1.9% in 1992-1993, 2.4% in 1994-1995.


CONCLUSIONS
The primary drug resistance of M. tuberculosis in Shanghai, 1985-1995, was in a trend of decline, but multi-drug resistance is still seriously existed.
Hu
Z
Z
Shanghai Tuberculosis Control Center, Shanghai 200031, China.
Cai
H
H
Li
L
L
D002681:China; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013997:Time Factors