title: Hyperadrenocorticism associated with excessive sex hormone production by an adrenocortical tumor in two dogs.
abstract: An 11-year-old spayed female Labrador Retriever and a 9-year-old castrated male miniature Poodle were evaluated because of clinical signs of hyperadrenocorticism. Cortisol testing did not support a diagnosis of hypercortisolemia in either dog; however, imaging studies revealed unilateral adrenal tumors in both dogs. Serum concentrations of 17-hydroxyprogesterone, progesterone, and estradiol were high in both dogs, and androstenedione concentrations were also high in 1 dog. It is suspected that sex hormone secretion by the adrenal tumors in these dogs resulted in clinical signs of hyperadrenocorticism. Clinical signs and hormonal abnormalities resolved in the male dog after surgical resection of the tumor. There was no improvement in clinical signs after treatment with mitotane in the female dog, which died 2 months after diagnosis. Histologic evaluation confirmed the presence of adrenocortical carcinoma in both dogs.
authors.affiliation: Department of Veterinary Clinical Sciences, School Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Syme
authors.forename: J C
authors.initials: JC
authors.lastname: Scott-Moncrieff
authors.forename: N G
authors.initials: NG
authors.lastname: Treadwell
authors.forename: M F
authors.initials: MF
authors.lastname: Thompson
authors.forename: P W
authors.initials: PW
authors.lastname: Snyder
authors.forename: M R
authors.initials: MR
authors.lastname: White
authors.forename: J W
authors.initials: JW
authors.lastname: Oliver
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D000315:Adrenalectomy / Q000191:economics / Q000662:veterinary; D018268:Adrenocortical Carcinoma / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D000308:Adrenocortical Hyperfunction / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D004283:Dog Diseases / Q000097:blood / Q000209:etiology* / Q000628:therapy; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008939:Mitotane / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D012739:Gonadal Steroid Hormones; D008939:Mitotane; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone