Future perspectives.
Transcription is coupled to splicing and other post-transcriptional processes. The importance of transcription factors in developmental biology and disease is underlined by genetic analysis in flies and humans. The genome project is identifying large numbers of novel transcription factors and RNA-binding proteins. Proteins may have multiple functions, acting at the transcriptional and post-transcriptional levels. The vast amount of novel biological information requires new, high-throughput approaches and bioinformatics.
Hastie
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MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, U.K. n.hastie@hgu.mrc.ac.uk
D000818:Animals; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D020033:Protein Isoforms; D012313:RNA / Q000378:metabolism; D014158:Transcription, Genetic
D020033:Protein Isoforms; D012313:RNA