title: Influence of human immunodeficiency virus type 1 infection on acute hepatitis A virus infection.
abstract: To assess the possible influence of human immunodeficiency virus type 1 (HIV-1) infection on the clinical course of acute hepatitis A virus (HAV) infection, 15 HIV-1-infected homosexual men and 15 non-HIV-infected age-matched subjects were compared. HAV load was higher in HIV-1-infected than in non-HIV-infected patients (P<.001). Duration of viremia in HIV-1-infected patients (median, 53 days) was significantly (P<.05) longer than in non-HIV-infected patients (median, 22 days). HIV-1-infected patients had lower elevations in alanine aminotransferase levels than did non-HIV-infected patients (P<.01) but had higher elevations in alkaline phosphatase levels than did non-HIV-infected patients (P<.001). Some HIV-1-infected patients still had HAV viremia when clinical symptoms had disappeared and alanine aminotransferase levels had returned to normal (60-90 days after the onset of symptoms). HIV-1 infection was associated with prolongation of HAV viremia, which might cause a long-lasting outbreak of HAV infection in HIV-1-infected homosexual men.
authors.affiliation: AIDS Clinical Center, International Medical Center of Japan, Tokyo 162-8655, Japan.
authors.forename: Setsuko
authors.initials: S
authors.lastname: Ida
authors.forename: Natsuo
authors.initials: N
authors.lastname: Tachikawa
authors.forename: Aya
authors.initials: A
authors.lastname: Nakajima
authors.forename: Manabu
authors.initials: M
authors.lastname: Daikoku
authors.forename: Michitami
authors.initials: M
authors.lastname: Yano
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Yasuoka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kimura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oka
mesh_terms: D000208:Acute Disease; D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006506:Hepatitis A / Q000209:etiology*; D030041:Hepatitis A virus / Q000235:genetics / Q000502:physiology*; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012698:Serologic Tests; D019562:Viral Load; D014766:Viremia / Q000821:virology
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase