title: Relation between body surface mapping and endocardial spread of ventricular activation in postinfarction heart.
abstract: BACKGROUND
  Body surface mapping (BSM) can be used to identify the site of earliest endocardial activation of ventricular tachycardias (VTs). The multielectrode QRS morphology during VT is determined by both the site of earliest activation and the subsequent spread of electrical activation through the ventricles. This study investigated the relationship between the site of earliest endocardial activation, endocardial spread of activation, and the morphology of the multielectrode surface map in patients with remote myocardial infarction.
  
  
  RESULTS
  In 14 patients with VT late (8.2+/-5.2 years) after myocardial infarction, BSM and simultaneous left ventricular 64-site basket endocardial mapping was performed during a total of 17 monomorphic VTs. In addition, multisite pacing by sequential use of the 64 basket electrodes was performed in 9 patients. BSM and basket mapping revealed the same endocardial breakthrough sites in 8 (47%) of 17 VTs and 189 (59%) of 322 pacing sites; adjacent sites were found in 2 (12%) of 17 VTs and 36 (11%) of 322 pacing sites. Large zones of conduction block explained the mismatch in localization in 2 (12%) of 17 VTs and 52 (16%) of 322 pacing sites. Regional differences in endocardial electrogram amplitudes were found as a cause for dissimilarity in 3 (18%) of 17 VTs and 73 (23%) of 322 pacing sites. Multiple endocardial breakthrough sites were found in 1 (6%) of 17 VTs and 8 (2%) of 322 pacing sites Finally, an epicardial exit site was suggested in 3 (18%) of 17 VTs as an explanation for mismatch, as no early endocardial activity could be recorded.
  
  
  CONCLUSIONS
  Zones of conduction block, regional differences in signal amplitude, and multiple endocardial breakthrough sites are frequent causes for mismatch between BSM and basket catheter activation mapping.
authors.affiliation: Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands. p.van.dessel@deskart.nl
authors.forename: P F
authors.initials: PF
authors.lastname: van Dessel
authors.forename: N M
authors.initials: NM
authors.lastname: van Hemel
authors.forename: J M
authors.initials: JM
authors.lastname: de Bakker
authors.forename: T A
authors.initials: TA
authors.lastname: Linnenbank
authors.forename: M
authors.initials: M
authors.lastname: Potse
authors.forename: E R
authors.initials: ER
authors.lastname: Jessurun
authors.forename: A
authors.initials: A
authors.lastname: SippensGroenewegen
authors.forename: E F
authors.initials: EF
authors.lastname: Wever
mesh_terms: D000368:Aged; D018780:Body Surface Potential Mapping; D002408:Catheters, Indwelling; D004567:Electrodes, Implanted; D022062:Electrophysiologic Techniques, Cardiac; D004699:Endocardium / Q000503:physiopathology*; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012815:Signal Processing, Computer-Assisted; D013223:Statistics as Topic; D017180:Tachycardia, Ventricular / Q000150:complications* / Q000175:diagnosis*