[Telomerase activity in stool of patients with colorectal cancer].
OBJECTIVE
To probe into the method for screening colorectal cancer by the way of stool.


METHODS
Telomerase activity in the stool of patients with colorectal cancer was determined by PCR-TRAP.


RESULTS
The positive rate of telomerase activity in the stool of patients with colorectal cancer was 62.8%. Its sensitivity, specificity and positive predictive value were 62.8%, 95.7%, and 96.4%, respectively. Telomerase activity in stool was not obviously correlated with Duke's stage, lymphatic metastasis and tumor location. Telomerase activity was also found in the stool sample of a patient with colonic adenoma.


CONCLUSIONS
The determination of telomerase activity in the stool of patients with colorectal cancer contributes to the improvement of screening and diagnosis of colorectal cancer.
Luo
C
C
Department of General Surgery, Beijing Military Area General Hospital, Beijing 100700, China.
Zhao
D
D
Qu
J
J
D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D005243:Feces / Q000737:chemistry*; D006801:Humans; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D019098:Telomerase / Q000378:metabolism*
D019098:Telomerase