[Peripheral markers, future perspectives].
Four of the recently described peripheral markers of alcohol abuse have been reviewed. The acetaldehyde adducts allow to detect an alcohol abuse lasting for several weeks, even after a recent alcohol withdrawal. Inversely, 5-hydroxytryptophol (5-HTOL) reflects the alcohol consumption of the last 24 hours. Its detection is possible after the blood alcohol concentration has disappeared. Its measurement is run in urine samples, thus without invasive sampling. The hyaluronic acid and the activity of beta-hexosaminidase are markers of hepatobiliary alcohol induced disorders more than direct markers of alcohol intake. Acetaldehyde adducts could be used as markers of long term alcohol abuse, CDT as a marker of the recent alcohol abuse, and 5-HTOL the detection of alcohol abuse of the past day.
Schellenberg
F
F
Laboratoire de biochimie, CHU Trousseau, 37044 Tours, France.
Nalpas
B
B
D000079:Acetaldehyde / Q000097:blood; D000437:Alcoholism / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D006917:Hydroxytryptophol / Q000097:blood; D001619:beta-N-Acetylhexosaminidases / Q000097:blood
D015415:Biomarkers; D006917:Hydroxytryptophol; D006820:Hyaluronic Acid; D001619:beta-N-Acetylhexosaminidases; D000079:Acetaldehyde
Marqueurs périphériques, perspectives d'avenir.