title: Clinicopathologic study of mucosa-associated lymphoid tissue lymphoma of the salivary gland.
abstract: OBJECTIVE
  To study the histopathologic features and pathogenesis of mucosa-associated lymphoid tissue lymphoma (MALT-oma) of salivary glands.
  
  
  METHODS
  Clinical data, paraffin-embedded sections, immunohistochemical slides (SP method) and electron microscopic features of surgical specimens of 32 cases of salivary gland MALT-oma were studied.
  
  
  RESULTS
  The patients were 27 males and 5 females, with a mean age of 54.76 years. The lesions were located in the parotid area in 17 cases, and in the submandibular gland in the remaining 15 cases. Much of the MALT-oma was replaced by infiltration of a great amount of centrocyte-like cells (CCL) as background and occasional large cells (centroblast- or immunoblast-like). In MALT-omas "lymphoepithelial lesions" were present. Immunohistochemically, CD20 expression was found to be positive and CD45RO expression was negative in all MALT-omas.
  
  
  CONCLUSIONS
  Most of the MALT-omas are low grade malignant tumors and have a "homing back" phenomenon. The cases were managed by surgery and chemotherapy. In a few MALT-omas which turned into high grade malignant tumors, the prognosis was poor. Acquired MALT may develop as a reaction to autoimmune disease and infection. Hyper-immune reaction and MALT hyperplasia under stimulation may result in myoepithelial sialadenitis and lead to MALT-oma of the salivary gland.
authors.affiliation: Department of Pathology, Nanjing General Hospital of PLA, Nanjing 210002, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Shi
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Xue
authors.forename: K
authors.initials: K
authors.lastname: Fan
authors.forename: G
authors.initials: G
authors.lastname: Sun
authors.forename: X
authors.initials: X
authors.lastname: Yan
authors.forename: B
authors.initials: B
authors.lastname: Shou
authors.forename: B
authors.initials: B
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology*