title: Blood concentration of essential trace elements and heavy metals in workers exposed to lead and cadmium.
abstract: The aim of the study was to determine blood concentration of essential trace elements (Se, Zn, Cu) and toxic metals (Pb, Cd), markers of antioxidant (activities of glutathione peroxidase (GPx), superoxidase dismutase and ceruloplasmin) and prooxidant processes (thiobarbituric acid reactive substances (TBARS)) in workers exposed to Pb and Cd. Forty three male workers of the lead-acid batteries department, aged 25-52 years, and twenty two workers, including 15 women, aged 36-51 years, exposed to Cd in the alkaline batteries department were examined. The reference group consisted of 52 healthy inhabitants of the same region. It was found that Se concentration and GPx activity in both erythrocytes and plasma of Cd exposed workers were significantly lower (p < 0.001) than in the reference group. We found an inverse linear correlation between blood Se and Cd concentrations in the workers exposed to Cd (r = -0.449; p < 0.01). Moreover, the activity of erythrocyte and plasma GPx was shown to be significantly lower in the study group of workers (p < 0.001). It was observed that TBARS concentration in plasma was significantly higher (p < 0.05) in the lead exposed workers than in the group without contact with Pb. Our results indicate that exposure to Pb and Cd affects the antioxidant potential of blood in workers exposed to heavy metals.
authors.affiliation: Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lódź, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Wasowicz
authors.forename: J
authors.initials: J
authors.lastname: Gromadzińska
authors.forename: K
authors.initials: K
authors.lastname: Rydzyński
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000032:analysis; D002104:Cadmium / Q000009:adverse effects / Q000097:blood*; D016022:Case-Control Studies; D015331:Cohort Studies; D003300:Copper / Q000097:blood; D005260:Female; D006801:Humans; D007854:Lead / Q000009:adverse effects / Q000097:blood*; D008297:Male; D008669:Metallurgy; D019216:Metals, Heavy / Q000009:adverse effects / Q000097:blood; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D016272:Occupational Health; D011044:Poland; D011336:Probability; D018570:Risk Assessment; D012494:Sampling Studies; D012643:Selenium / Q000097:blood; D018709:Statistics, Nonparametric; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D000975:Antioxidants; D019216:Metals, Heavy; D014131:Trace Elements; D002104:Cadmium; D007854:Lead; D003300:Copper; D012643:Selenium; D015032:Zinc