[Research progress of fibroblast and wound repair].
OBJECTIVE
To review the recent advances in fibroblast study and its role in wound repair.


METHODS
Recent original articles related to wound repair were retrieved extensively, and the effect of fibroblast on every stages of repair were summed up and comprehended.


RESULTS
Fibroblast plays important roles in granulation formation, wound contraction, matrix synthesis, wound repair, scar formation and scarless repair by means of growth factors modulation.


CONCLUSIONS
The understanding of fibroblast in the wound repair can promote the progress of biological therapy of wound repair and scar prevention.
Wang
Y
Y
Department of Pediatric Surgery, First University Hospital, West China University of Medical Sciences, Chengdu Sichuan, P. R. China 610041.
Wei
F
F
Liu
M
M
D000818:Animals; D000077214:Becaplermin; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D020574:Proto-Oncogene Proteins c-sis; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D016212:Transforming Growth Factor beta; C075278:platelet-derived growth factor A; D016222:Fibroblast Growth Factor 2; D000077214:Becaplermin