title: Temporal fluctuations of myocardia high-energy phosphate metabolite with the cardiac cycle.
abstract: This review describes the temporal changes of high-energy phosphate metabolites during the cardiac cycle. Under baseline condition, the extent of cyclical changes ("cycling") of ATP, phosphocreatine and inorganic phosphate varies between 10-15%. Such energy oscillations are not augmented under various forms of metabolic stress including 1) inotropic stimulation, 2) acute hypoxia and 3) failing, chronically infarcted hearts. Thus, the concentrations of high-energy phosphates over the cardiac cycle are a tightly regulated entity, even when energetic needs are substantially augmented.
authors.affiliation: Medizinische Universitätsklinik Würzburg, Germany. spindler@mail.uni-wuerzburg.de
authors.forename: M
authors.initials: M
authors.lastname: Spindler
authors.forename: B
authors.initials: B
authors.lastname: Illing
authors.forename: M
authors.initials: M
authors.lastname: Horn
authors.forename: M
authors.initials: M
authors.lastname: de Groot
authors.forename: G
authors.initials: G
authors.lastname: Ertl
authors.forename: S
authors.initials: S
authors.lastname: Neubauer
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*
chemical_list: D000255:Adenosine Triphosphate