[Role of apoptotic cell death in radioinduced aging in Drosophila melanogaster].
The attempt in made to estimate a role of programmed cell death (apoptosis) in radio-induced life span alteration and aging. It was shown with the use of mutant Drosophila melanogaster laboratory strains, that the disfunction of a reaper-dependent apoptosis pathway, together with the action of ionizing radiation and/or apoptosis inductor etoposide, could lead to change of life span and a pace of aging. In Drosophila strain with defect of proapoptosis gene reaper, the increase of life span after irradiation and etoposide treatment was observed. At the same time the strain with overexpression of a protease dcp-1 gene and the strain with the defect of antiapoptosis diap-1/th gene decreased the life span after irradiation and etoposide treatment. The obtained facts are discussed from a position of participation of apoptosis deregulation in radio-induced and natural aging of whole organisms.
Moskalev
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Institute of Biology, Komi Scientific Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, 167982 Russia. moskalev@ib.komisc.ru
Zaĭnullin
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VG
D000375:Aging / Q000473:pathology*; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000528:radiation effects*; D020169:Caspases / Q000235:genetics; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics / Q000502:physiology / Q000528:radiation effects*; D005047:Etoposide / Q000008:administration & dosage; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins / Q000235:genetics
C111891:DIAP1 protein, Drosophila; D029721:Drosophila Proteins; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins; D005047:Etoposide; D020169:Caspases; C103568:Dcp-1 protein, Drosophila
Izuchenie role apoptoticheskoĭ gibeli kletki u Drosophila melanogaster.