title: [Analysis of the clinical characteristics and the pathology of large cell lung cancer].
abstract: OBJECTIVE
  To study the clinical characteristics and the pathology of large cell lung cancer (LCLC).
  
  
  METHODS
  Comparing the microscopic and immunohistochemical findings with clinical data by analyzing 54 cases of surgically treated LCLC from 1978 to 1997.
  
  
  RESULTS
  There were 6 cases of clear cell carcinoma and one case of giant cell carcinoma in 54 cases. Male:female was 5:1(45/9). LCLC accounted for 1.28% of all surgically treated lung cancers. The average survival time was 23 months. The positive rate of P53 protein expression was 65%(13/20). The positive rate of PCNA staining was 100%(20/20).
  
  
  CONCLUSIONS
  LCLC may be divided into squamous type, adenomatous type, neuroendocrine type and undifferentiated type.
authors.affiliation: Dept. of Pathology, Thoracic Tumor & Tuberculosis Hospital of Beijing, Beijing 101149.
authors.forename: F
authors.initials: F
authors.lastname: Lü
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D018287:Carcinoma, Large Cell / Q000145:classification / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D012189:Retrospective Studies; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53