title: MUNIN: application of three-way decomposition to the analysis of heteronuclear NMR relaxation data.
abstract: MUNIN (Multidimensional NMR Spectra Interpretation), a recently introduced approach exploiting the mathematical concept of three-way decomposition, is proposed for separation and quantitative relaxation measurements of strongly overlapped resonances in sets of heteronuclear two-dimensional spectra that result from typical relaxation experiments. The approach is general and may also be applied to sets of two-dimensional spectra with arbitrary modulation along the third dimension (e.g., J-coupling, diffusion). Here, the method is applied for the analysis of 15N rotating frame relaxation data.
authors.affiliation: Swedish NMR Centre at Göteborg University.
authors.forename: D M
authors.initials: DM
authors.lastname: Korzhneva
authors.forename: I V
authors.initials: IV
authors.lastname: Ibraghimov
authors.forename: M
authors.initials: M
authors.lastname: Billeter
authors.forename: V Y
authors.initials: VY
authors.lastname: Orekhov
mesh_terms: D001400:Azurin / Q000737:chemistry; D002213:Capsid / Q000737:chemistry; D036022:Capsid Proteins; D003627:Data Interpretation, Statistical; D008565:Membrane Proteins / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D012399:Rotation
chemical_list: D036022:Capsid Proteins; D008565:Membrane Proteins; D011506:Proteins; C025668:coat protein, Bacteriophage M13; D001400:Azurin