title: Massive mediastinal seminoma post-orchidectomy--late relapse with skip-metastases or new primary?
abstract: A case of a massive, biopsy-proven, advanced seminoma in the mediastinum 12 years after orchidectomy for a malignant right-sided testicular tumour of unknown histology is presented. The highly unusual nature of this presentation is discussed and may represent either late relapse from skip-metastases or metachronous gonadal and extragonadal tumour development. Immunohistochemical staining was unable to distinguish the site of origin of the lesion.
authors.affiliation: Institute of Urology, London, UK. richard.brown@ucl.ac.uk
authors.forename: R S
authors.initials: RS
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Hayne
authors.forename: R J
authors.initials: RJ
authors.lastname: Burcombe
authors.forename: L J
authors.initials: LJ
authors.lastname: Harbin
authors.forename: C A
authors.initials: CA
authors.lastname: Coulter
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D009382:Neoplasms, Unknown Primary; D009919:Orchiectomy; D018239:Seminoma / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D013736:Testicular Neoplasms / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed