title: A study of cranial computer tomograms in very early and early onset schizophrenia.
abstract: The cranial computer-assisted tomograms of 19 patients suffering from schizophrenic psychoses with onset by age of 14 were examined. The emphasis was on the extent of the inner liquor spaces. Compared to healthy controls, at the beginning of illness a significant enlargement was revealed only in the patient group with very early onset schizophrenia (VEOS, onset prior to the age of 12), whereas children with early onset (EOS, 12 to 14 years of age) showed no significant brain pathology. As a second result, an increase in the extent of the inner liquor spaces seems to correlate with the duration of illness. It is therefore concluded that psychoses interfere with neurodevelopmental processes and cause more severe brain pathology in very young children, already detectable at the onset of the illness. EOS, on the other hand, induces progressive morphological abnormalities over the course of the illness.
authors.affiliation: Department of Child an Adolescent Psychiatry, University of Würzburg, Federal Republic of Germany.
authors.forename: F
authors.initials: F
authors.lastname: Badura
authors.forename: G E
authors.initials: GE
authors.lastname: Trott
authors.forename: C
authors.initials: C
authors.lastname: Mehler-Wex
authors.forename: P
authors.initials: P
authors.lastname: Scheuerpflug
authors.forename: E
authors.initials: E
authors.lastname: Hofmann
authors.forename: M
authors.initials: M
authors.lastname: Warmuth-Metz
authors.forename: M
authors.initials: M
authors.lastname: Nadjmi
authors.forename: L
authors.initials: L
authors.lastname: Solymosi
authors.forename: A
authors.initials: A
authors.lastname: Warnke
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology*; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000706:statistics & numerical data