A new bicoumarin from Stellera chamaejasme L.
Thirteen compounds were isolated from roots of Stellera chamaejasme L. (Thymelaeaceae). They are 3-sitosterol (2), simplexin (3), pimelea factor P2 (4), daucosterol (5), (+)-3-hydroxy-1,5-diphenyl-1-pentanone (6), 4-ethoxy-benzoic acid (7), 2,4,6-Trimethoxy-benzoic acid (8), (+)-afzelechin (9), fumaric acid (10), N,N-dimethyl-L-aspartic acid (11), umbelliferone (12), daphniretin (13) and a novel bicoumarin named bicoumastechamin (1). Among the known compounds, 7, 8, 9, 10 and 11 were first isolated from this plant, and 6 was first isolated from the natural resources. Their structures have been elucidated on the basis of spectral data. In vitro bioassays showed that 4 inhibited cancer cell growth, 13 exhibited immunomodulatory activity, and 6 exhibited both immunomodulatory and anti-tumor activity.
Xu
Z H
ZH
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Qin
G W
GW
Xu
R S
RS
D002850:Chromatography, Gel; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D029645:Thymelaeaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D003374:Coumarins; D004365:Drugs, Chinese Herbal; C451583:bicoumastechamin