[Effect of ethanol on methanol immunotoxicity].
The results of experiments on Wistar rats under acute methanol poisoning conditions (1 LD 50) showed that ethanol serves as an antidote of methanol. Ethanol reduces nonspecific resistance of the organism and decreases activity of the native killer cells, antibody production mainly with respect to the T-dependent antigen, antibody-mediated cell cytotoxicity, and the formation of delayed type hypersensitivity.
Zabrodskiĭ
P F
PF
Toxicology Department, Saratov State Medical University, ul. Il'inskaya 17, Saratov, 410037 Russia.
Germanchuk
V G
VG
D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000931:Antidotes / Q000627:therapeutic use*; D000431:Ethanol / Q000627:therapeutic use*; D007111:Immunity, Cellular / Q000187:drug effects; D000432:Methanol / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar
D000931:Antidotes; D000431:Ethanol; D000432:Methanol
Vliianie étanola na izmenenie immunotoksichnosti metanola.