[Expression of nitric oxide synthase in squamous cell carcinoma of tongue and its prognosis].
OBJECTIVE
To study the expression of nitric oxide synthase (NOS) in squamous cell carcinoma of tongue and its prognosis.


METHODS
The NOSI, NOSII and NOSIII of 55 cases of squamous cell carcinoma of tongue were detected by immunohistochemistry.


RESULTS
The expressive rates of NOSI, NOSII and NOSIII were 30.9%, 40.0% and 38.2% respectively. There were significant differences between the patients with and without neck nodal metastasis, and between the patients survival more than 5 years and less than 5 years (P < 0.01), There were differences between G1, G2 and G3 and the clinical stages in NOSII (P < 0.05).


CONCLUSIONS
The expression of the NOSI, NOSII and NOSIII in squamous cell carcinoma of tongue is raleted to its prognosis and the NOSII plays a more important role in growth, differentiation, metastatic capability and prognosis of the tumor.
Chen
W
W
Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510120.
Li
H
H
Pan
C
C
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000032:analysis*; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D011379:Prognosis; D014062:Tongue Neoplasms / Q000201:enzymology* / Q000473:pathology
D009569:Nitric Oxide; C496320:NOS1 protein, human; C496319:NOS2 protein, human; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III