title: ADCON-L hydrogel as a vitreous substitute: preliminary results.
abstract: The ideal vitreous substitute has still to be found. This report concerns the preliminary results of a translucent hydrogel, ADCON-L, used successfully in neurosurgery. We have used this hydrogel as a vitreous substitute in the right eye of New-Zealand albino rabbits following vitrectomy. The follow-up period was four weeks and the evaluation was followed by biomicroscopy, indirect ophthalmoscopy, and electroretinography. The results obtained suggest a potential retinotoxicity of this hydrogel as shown by the statistically significant reduction of the mean B-wave amplitude at day 14 (p < 0.05) and day 28 (p < 0.005), as well as an important postoperative inflammatory reaction. Another transparent formulation of the same molecule is currently under investigation.
authors.affiliation: Department of Ophthalmology, University Hospitals Saint-Pierre and Brugmann, Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: De Jong
authors.forename: E
authors.initials: E
authors.lastname: Bali
authors.forename: J
authors.initials: J
authors.lastname: Libert
authors.forename: L
authors.initials: L
authors.lastname: Caspers-Velu
mesh_terms: D000818:Animals; D003318:Corneal Opacity / Q000139:chemically induced; D004596:Electroretinography; D005260:Female; D005355:Fibrosis; D005782:Gels / Q000633:toxicity*; D007908:Lens, Crystalline / Q000473:pathology; D009930:Organic Chemicals; D019736:Prostheses and Implants / Q000009:adverse effects*; D011817:Rabbits; D012160:Retina / Q000187:drug effects; D014822:Vitreous Body / Q000601:surgery*
chemical_list: C104199:ADCON-L; D005782:Gels; D009930:Organic Chemicals