[Antioxidant effect of novel probucol analogs and their combinations with alpha-tocopherol].
The antioxidant and antiradical activities of sulfur containing phenols which are analogues of probucol in comparison with alpha-tocopherol and BHT were tested using initiated methyl oleate oxidation model. The antioxidant effect linearly increased with increasing concentration of phenols. The ability of investigated phenols to destroy and reduced accumulation of hydroperoxides is revealed. The combined inhibitory effects of composition most effective researched antioxidant--CO-3--with alpha-tocopherol for the first time are described.
Storozhok
N M
NM
Tyumen State Medical Academy, 625023, Tyumen, st Odesskaya, 52.
Krysin
A P
AP
Gureeva
N V
NV
D000975:Antioxidants / Q000737:chemistry*; D004357:Drug Synergism; D005395:Fish Oils / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D008163:Luminescent Measurements; D009829:Oleic Acids / Q000737:chemistry; D010084:Oxidation-Reduction; D011341:Probucol / Q000031:analogs & derivatives* / Q000737:chemistry*; D013329:Structure-Activity Relationship; D024502:alpha-Tocopherol / Q000737:chemistry*
D000975:Antioxidants; D005395:Fish Oils; D005609:Free Radicals; D009829:Oleic Acids; C443440:bis-(3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)propyl)sulfide; C005576:methyl oleate; D024502:alpha-Tocopherol; D011341:Probucol
Antioksidantnoe deĭstvie novykh analogov probukola i ikh kompozitsiĭ s al'fa-tokoferolom.