[Clinical study of treating infantile acute nephritis with antipyretic and detoxication, cooling blood and diuretic principle].
OBJECTIVE
To find out the relationship between nitric oxide and onset of infantile acute nephritis, and the effect of traditional Chinese medicine (TCM) and Western medicine (WM) combination therapy.


METHODS
Dividing 44 infantile acute nephritis patients into two groups. Group 1 was treated with cooling blood and diuretic principle, together with WM, Group 2 was treated with antipyretic and detoxication, cooling blood and diuretic principle, together with WM. The content of nitrite/nitrate iron (Fe NO2/NO3) in blood before and after treatment were determined through Griess nitrate reduction method, then compared with that of 28 healthy children.


RESULTS
The content of Fe NO2/NO3 being in acute nephritis period was obvious higher than that of control group and reconvalecent period, P < 0.01. The macroscopic hematuria was higher than that of microscopic hematuria, P < 0.01. Urinary alexin third element (C3) and alpha 2-macroglobulin (alpha 2-M) positive patients Fe NO2/NO3 was higher than that of negative ones, P < 0.01. Those complicated with infection Fe NO2/NO3 was higher than that without infection P < 0.01. Short term cure rate of group 2 was higher than that of group 1, P < 0.05. Nitric oxide may participate the onset and pathogenesis of infantile acute nephritis.


CONCLUSIONS
TCM-WM combination therapy, especially antipyretic and detoxication, cooling blood and diuretic principle, could restrain nitric oxide from damaging tissue and remitting disease.
Zhang
W
W
Nanjing Municipal Hospital of Children, Nanjing (210008).
Li
J
J
D000208:Acute Disease; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009393:Nephritis / Q000188:drug therapy*; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy
D018712:Analgesics, Non-Narcotic; D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide