title: Cisternal MHPG level inversely correlates with Glasgow coma scale after aneurysmal subarachnoid hemorrhage.
abstract: We measured the concentrations of monoamines and amino acids in the cisternal cerebrospinal fluid obtained from 15 patients after aneurysmal subarachnoid hemorrhage. Based on the Glasgow Coma Scale (GCS), the patients were divided into two conscious (GCS always 14 or better from the third post-operative day to Day 12; n = 8) and unconscious groups (n = 7). We examined the concentrations of monoamines and amino acids between the two groups and evaluated the correlation between the concentrations and the GCS at CSF sampling. The concentration of MHPG was significantly higher in the unconscious than in the conscious group from Days 4 to 12. A significant inverse correlation was observed between the MHPG concentration and the GCS (r = approximately 0.635, p < 0.0001). Measuring the cisternal MHPG concentration may be useful for estimating convalescence after subarachnoid hemorrhage.
authors.affiliation: Department of Neurosurgery, National Defense Medical College, Saitama, Japan. hiroshik@me.ndmc.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Katoh
authors.forename: K
authors.initials: K
authors.lastname: Shima
authors.forename: N
authors.initials: N
authors.lastname: Tsuzuki
authors.forename: S
authors.initials: S
authors.lastname: Ishihara
authors.forename: H
authors.initials: H
authors.lastname: Nawashiro
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: A
authors.initials: A
authors.lastname: Ohnuki
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Fukui
authors.forename: N
authors.initials: N
authors.lastname: Nomura
mesh_terms: D000368:Aged; D002946:Cisterna Magna; D003243:Consciousness; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000378:metabolism; D011237:Predictive Value of Tests; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000534:rehabilitation; D014474:Unconsciousness / Q000134:cerebrospinal fluid / Q000175:diagnosis
chemical_list: D010108:Oxyhemoglobins; D008734:Methoxyhydroxyphenylglycol