[Combining transvaginal sonography and endometrial cytology in the diagnosis of endometrial disorders in postmenopausal women].
OBJECTIVE
To evaluate the combined use of transvaginal sonography and endometrial cytology for the diagnosis of endometrial disorders in postmenopausal women.


METHODS
One hundred forty-three patients with postmenopausal uterine bleeding were studied prospectively. Transvaginal sonography was used to measure the endometrial thickness (double layers), followed by use of the ori endometrial sampler. The results were compared to the histopathologic diagnosis of specimens obtained by dilatation and curettage.


RESULTS
When the cutoff point of endometrial thickness was set at 5 mm to detect endometrial malignancy and premalignancy, transvaginal sonography showed a 100.0% sensitivity and 56.9% false positive rate. Endometrial cytology showed a 96.3% specificity but it had a 2.5% false negative rate. The combined use of transvaginal sonography and endometrial cytology can decrease false positive rate of transvaginal sonography from 56.9% to 43.2% (P < 0.01).


CONCLUSIONS
The combined use of transvaginal sonography and endometrial cytology is a good method to screen endometrial malignancy and premalignancy.
Sheng
J
J
Department of Gynecology, Beijing Obstetric and Gynecology Hospital, Affiliated to Medical Science of Capital University, Beijing 100006, China.
Chen
Y
Y
Pan
J
J
D000328:Adult; D000368:Aged; D004714:Endometrial Hyperplasia / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D011230:Precancerous Conditions / Q000175:diagnosis / Q000000981:diagnostic imaging; D014463:Ultrasonography / Q000379:methods*; D014626:Vaginal Smears