Regulating sister chromatid separation by separase phosphorylation.
A recent paper in Cell highlights a second mechanism of regulation of separase in addition to the bound inhibitor securin. This second pathway involves separase phosphorylation and is dependent on CDC2.
Nagao
Koji
K
Department of Biophysics, Graduate School of Science, Kyoto University, 606-8502 Kyoto, Japan.
Yanagida
Mitsuhiro
M
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002842:Chromatids / Q000378:metabolism*; D010450:Endopeptidases; D010766:Phosphorylation; D016196:S Phase / Q000502:physiology; D064247:Separase
D018797:Cell Cycle Proteins; D010450:Endopeptidases; D064247:Separase