title: Relationship between serum müllerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women.
abstract: OBJECTIVE
  To examine the relationship of serum müllerian-inhibiting substance (MIS), E(2), free-T, LH, and FSH in untreated women with polycystic ovary syndrome (PCOS) and in women with normal menstrual cycles.
  
  
  METHODS
  A prospective study.
  
  
  METHODS
  University Departments of Obstetrics and Gynecology and Surgery.
  
  
  METHODS
  Twenty-seven women with PCOS and 20 women with normal menstrual cycles.
  
  
  METHODS
  Serum was collected from women with PCOS and from normal women during the early follicular phase of the menstrual cycle, stored frozen until assayed.
  
  
  METHODS
  Serum levels of MIS, E(2), free-T, TSH, LH, and FSH were measured.
  
  
  RESULTS
  Serum müllerian-inhibiting substance levels in PCOS patients were significantly higher compared with normal women (+/- SE; 5.3 +/- 0.7 and 1.4 +/- 0.2 ng/mL, respectively). An inverse correlation (r = -0.5965) was found between serum levels of MIS and E(2) in PCOS women, but not in normal women. Women with PCOS had higher serum LH levels than those of normal women (15.2 +/- 1.2 and 5.0 +/- 0.7 mIU/mL).
  
  
  CONCLUSIONS
  In this study, women with PCOS have significantly higher serum MIS levels than normal women. The inverse relationship between müllerian-inhibiting substance and E(2) levels suggests that MIS may modulate ovarian E(2) synthesis and have a role in the disordered folliculogenesis characteristic of PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, University of Louisville, Louisville, Kentucky 40292, USA. clcook01@gwise.louisville.org
authors.forename: Christine L
authors.initials: CL
authors.lastname: Cook
authors.forename: Yong
authors.initials: Y
authors.lastname: Siow
authors.forename: Amy G
authors.initials: AG
authors.lastname: Brenner
authors.forename: Mary E
authors.initials: ME
authors.lastname: Fallat
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone; D015415:Biomarkers / Q000097:blood; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005498:Follicular Phase; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D009095:Mullerian Ducts; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012016:Reference Values; D012044:Regression Analysis; D013735:Testicular Hormones / Q000097:blood*; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood
chemical_list: D015415:Biomarkers; D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D013739:Testosterone; D004958:Estradiol; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin