title: September 2001: 51-year-old man with seizures since childhood.
abstract: The September 2001 COM. A 51 year old man with refractory seizures presented with a recent seizure while at work but no other neurologic deficit. Imaging studies demonstrated a solid and cystic lesion of the right temporal lobe. Microscopic and immunohistochemical studies demonstrated an atypical ganglioglioma due to the presence of neurofibrillary tangles within the neoplastic ganglion cell component. This is the fifth case reported in the literature. Neoplastic ganglion cells and neurofibrillary tangles are discussed both separately and as integral components of this rare tumor.
authors.affiliation: Department of Pathology, University of Rochester Medical Center, NY, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Raffo
authors.forename: Ana
authors.initials: A
authors.lastname: Rubio
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Rodenhouse
authors.forename: Uresh
authors.initials: U
authors.lastname: Patel
authors.forename: Thomas
authors.initials: T
authors.lastname: Bonfigilo
authors.forename: James M
authors.initials: JM
authors.lastname: Powers
mesh_terms: D001253:Astrocytes / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D019070:Cell Lineage / Q000502:physiology; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D018303:Ganglioglioma / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology; D009474:Neurons / Q000473:pathology; D019635:Neurosurgical Procedures; D012640:Seizures / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D013234:Stem Cells / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome