[Analysis of polymorphic variants of renin-angiotensin system genes in polymetabolic syndrome and non-insulin-dependent diabetes].
Polymorphisms of the genes for angiotensin-converting enzyme (ACE) and angiotensinogen, the proteins of the renin-angiotensin system (RAS), were tested for association with the polymetabolic syndrome (PMS) and non-insulin-dependent diabetes mellitus (NIDDM) in the Moscow population. The insertional (I) allele and genotype II of the ACE gene proved to be associated with PMS. A significant difference in allele and genotype frequency distributions of the (CA)n microsatellite of the 3'-untranslated exon of the angiotensinogen gene was revealed between randomly sampled individuals and patients with PMS and IDDM from the Moscow population.
Miloserdova
O V
OV
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russia.
Perova
N V
NV
Balabolkin
M I
MI
Slominskiĭ
P A
PA
Limborskaia
S A
SA
D020413:3' Untranslated Regions; D000328:Adult; D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D009031:Moscow; D016254:Mutagenesis, Insertional; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics*
D020413:3' Untranslated Regions
Analiz polimorfnykh variantov genov renin-angiotenzinovoĭ sistemy pri polimetabolicheskom sindrome i insulin-nezavisimom sakharnom diabete.