[Correlation between the expression of vascular endothelial growth factor and prognosis of lung cancinoma].
OBJECTIVE
To determine the association between the expression of vascular endothelial growth factor (VEGF) and prognosis of lung cancer.


METHODS
Apply the SP immunohistochemistry stain method to investigate the expression of VEGF in 60 specimens of patients with lung cancer, who had undergone curative resection more than 36 months before.


RESULTS
The VEGF stain positive rate is 60% in 60 cases of lung cancer specimens; The immunoreactivity of VEGF was almost exclusively restricted to the tumor cells, the positive expression of VEGF showed significantly higher in the patients with lymph node metastasis and/or relapse. The positive rates of VEGF were higher in N1, N2 groups (53%, 80%) than in No group (23%, P < 0.01), and in relapse group (80%) than in non-relapse group (53%, P < 0.05). Postoperative survival time was shorter in VEGF(+) group (31 +/- 7 months) than in VEGF(-) group (64 +/- 7 months, P < 0.05). The 3, 5 year survival rates showed significant difference between VEGF(+) (31%, 11%) and VEGF(-) (88%, 50%) groups.


CONCLUSIONS
The results suggest VEGF is a reliable prognostic parameter and antiangiogenesis therapy will be a useful strategy in treatment of the human lung cancer.
Ren
Y
Y
Department of Thoracic Surgery, Hebei Chest Hospital, Shijiazhuang 050041.
Li
X
X
Zhang
J
J
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D016228:Endothelial Growth Factors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D008222:Lymphokines / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013223:Statistics as Topic; D016019:Survival Analysis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D014408:Biomarkers, Tumor; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors