title: [Diagnosis of seronegative chronic hepatitis in tissue].
abstract: The evaluation of a liver biopsy in chronic hepatitis should make a statement on the etiology and report the degree of activity and stage of the disease. The category of so called seronegative chronic hepatitis may include cases of chronic hepatitis C or infection with other viruses such as the Epstein-Barr virus (EBV) and cytomegalovirus (CMV), cases of marker-negative autoimmune hepatitis as well as drug-induced injury and Wilson's disease in younger patients. In order to establish the diagnosis, sensitive techniques of molecular biology should be applied as well as copper staining by histochemistry. Exact and detailed histopathologic analysis can reveal certain features of autoimmune hepatitis or drug injury.
authors.affiliation: Institut für Pathologie, Universität zu Köln.
authors.forename: U
authors.initials: U
authors.lastname: Drebber
authors.forename: M
authors.initials: M
authors.lastname: Odenthal
authors.forename: V
authors.initials: V
authors.lastname: Dries
authors.forename: P
authors.initials: P
authors.lastname: Schrimacher
authors.forename: H P
authors.initials: HP
authors.lastname: Diennes
mesh_terms: D001706:Biopsy; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000175:diagnosis / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000473:pathology; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000175:diagnosis* / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology
vernacular_title: Diagnostik der "seronegativen" chronischen Hepatitis am Gewebe.