[Effects of ovulation induction on expression of integrins alpha 4 beta 1 in endometrium].
OBJECTIVE
To study the effect of clomiphene citrate (CC) and human menopausal gonadotropin (hMG) on the expression of integrins alpha 4 beta 1 during implantation window in endometrium.


METHODS
Endometrium integrin alpha 4 beta 1 expression was detected by immunohistochemistry method in the mid-secretory phase of 48 normal natural cycles. CC + hCG or CC + hMG + hCG cycles in 30 polycystic ovary syndrome (PCOS) patients and 48 normal women.


RESULTS
The expression of endometrial integrin alpha 4 beta 1 was stronger in the natural cycles than those of ovulation induction cycles with CC + hCG or CC + hMG + hCG. So was the pregnancy cycles as compared with the non-pregnant cycles.


CONCLUSIONS
The endometrial receptivity in the min luteal phase and pregnant rate declined during ovulation induction by CC + hCG or CC + hMG + hCG in either normal women or PCOS patients.
Wang
Y
Y
Department of Obstetrics and Gynecology, Third Clinical Hospital, Peking University, Beijing 100083, China.
Chen
Y
Y
Li
M
M
D000328:Adult; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D039041:Integrin alpha4beta1; D016023:Integrins / Q000096:biosynthesis*; D008597:Menstrual Cycle; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology; D016201:Receptors, Lymphocyte Homing / Q000096:biosynthesis*
D039041:Integrin alpha4beta1; D016023:Integrins; D016201:Receptors, Lymphocyte Homing