[The activity of cathepsin B in colorectal adenocarcinomas].
The aim of the present study was to evaluate the activity of cathepsin B in 36 colorectal adenocarcinomas at stage pT3 of clinical advancement and histological grade G2. A correlation was also analysed of cathepsin B activity with the stage of anatomo-clinical advancement and the presence of chosen anatomo-clinical features of the tumour. Statistically significantly higher activity of cathepsin B was observed both in the cytosol and homogenate of the neoplastic tissue compared to its activity in the cytosol and homogenate of the adjacent unchanged tissue. A tendency was found towards higher cathepsin B activity in homogenate than in cytosol, both in the neoplastic and normal tissue. No correlation was revealed between cathepsin B activity in neoplastic cells and other anatomo-clinical tumour parameters analysed.
Chabowski
A
A
Zakład Fizjologii Akademii Medycznej w Białymstoku.
Skrzydlewska
E
E
Sulkowska
M
M
Famulski
W
W
Sulkowski
S
S
Chrzanowska
A
A
D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D000328:Adult; D002401:Cathepsin B / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
D002401:Cathepsin B
Aktywność katepsyny B u chorych na raka jelita grubego.