title: [Effect of mifepristone on the expression of tumor necrosis factor-alpha and transforming growth factor-beta in decidua of early pregnancy].
abstract: OBJECTIVE
  To investigate the effect of mifepristone on the expression of tumor necrosis factor-alpha(TNF-alpha) and transforming growth factor-beta(TGF-beta) in decidua of early pregnancy.
  
  
  METHODS
  Thirty artificial abortion women as control and thirty drug abortion women were enrolled for study. The expressions of TNF-alpha and TGF-beta in decidua were measured with immunohistochemical method.
  
  
  RESULTS
  There was no significant difference of TNF-alpha positive expression rates between drug abortion group (73.33%) and artificial abortion group (70.00%, P > 0.05). TGF-beta expression rate of drug abortion group was similar to that of artificial abortion group. The highly-positive (++ and +++) TNF-alpha expression rate in drug abortion group was significantly higher than that in artificial abortion group (P < 0.05). TGF-beta expression degree in decidua of drug abortion group was significantly lower than that of artificial abortion group (P < 0.05). The ratio of TNF-alpha/TGF-beta in drug abortion group is higher than that in artificial abortion group.
  
  
  CONCLUSIONS
  TGF-beta has great effect on regulating the embryo development of early pregnancy. The change of TNF-alpha may be the reason of abortion. Mifepristone may interfere with embryo growth by inhibiting the activity of TGF-beta or by stimulating the secretion of TNF-alpha.
authors.affiliation: Department of Obstetrics and Gynecology, Beijing 402 Hospital, Beijing 100039, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: E
authors.initials: E
authors.lastname: Xia
authors.forename: J
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology*; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy / Q000378:metabolism*; D011261:Pregnancy Trimester, First / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D000021:Abortifacient Agents, Steroidal; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D015735:Mifepristone