title: Ebola virus: the search for vaccines and treatments.
abstract: Ebola viruses belong to the family Filoviridae, which are among the most virulent infectious agents known. These viruses cause acute, and frequently fatal, hemorrhagic fever in humans and nonhuman primates. Currently, no vaccines or treatments are available for human use. This review describes Ebola viruses, with a particular focus on the status of research efforts to develop vaccines and therapeutics and to identify the immune mechanisms of protection.
authors.affiliation: Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Wilson
authors.forename: C M
authors.initials: CM
authors.lastname: Bosio
authors.forename: M K
authors.initials: MK
authors.lastname: Hart
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000998:Antiviral Agents / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D029043:Ebolavirus / Q000187:drug effects / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology*; D005814:Genes, Viral; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D016207:Cytokines; D014764:Viral Proteins; D014765:Viral Vaccines