[Use of heterogeneous acelluar dermal matrix and autologous overthin split-thickness skin for repair of deep burn at articular sites].
OBJECTIVE
To investigate the effect of heterogeneous (swine) acellular dermal matrix (s-ADM) and autologous overthin split-thickness skin (auto-OTS) composite grafting in repair of deep burns at articular sites.


METHODS
From May 1999 to April 2000, 19 articular sites in 16 patients, including 14 males and 2 females, were treated. In all the 19 sites of deep burn, the total burn area varied from 2% to 48% and the full-thickness burn area varied from 1% to 35%. After the primary escharectomy (1 to 5 days later) and complete hemostasis, the s-ADM was utilized to cover the exposed articular sites and the auto-OTS was transferred on the surface of sutured s-ADM. The size of s-ADM applied to each patient varied from 25 cm2 to 150 cm2. Regular skin grafting was adopted elsewhere other than the articular site. The survival rate of all skin grafting was evaluated and pathological examination was performed.


RESULTS
The survival rate of the composite skin was (90.80 +/- 18.34)%, which was obvious higher than the survival rate of contiguous granulosum skin grafting (P < 0.05) and almost the same with that of snip skin grafting(P > 0.05). The survived composite skin appeared as smooth and soft as normal skin, and the function of articular site almost recovered with neglectable hypertrophic scar. The pathological examination revealed that the normal cell grew into s-ADM with regularly arranged collagen fiber and neovascularization in the matrix.


CONCLUSIONS
The combination of s-ADM and auto-OTS graft is cheap and effective method to cover wound and minimize hypertrophic scar.
Chen
B
B
Department of Burn Surgery, Second Affiliated Hospital of Kunming Medical College, Kunming Yunnan, P. R. China 650101.
Fu
J F
JF
Cao
W D
WD
D000293:Adolescent; D000328:Adult; D000818:Animals; D002056:Burns / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D006801:Humans; D008875:Middle Aged; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D013552:Swine; D016042:Transplantation, Heterotopic; D014945:Wound Healing