Why is p53 acetylated?
Recent studies suggest that acetylation of the p53 tumor suppressor protein is not important for its DNA binding activity, as was previously thought. We discuss here a number of theories as to how this modification may serve to regulate the protein's functions.
Prives
C
C
Department of Biological Sciences, Columbia University, New York, NY 10027, USA. clp@columbia.edu
Manley
J L
JL
D000107:Acetylation; D000818:Animals; D002453:Cell Cycle; D016923:Cell Death; D004260:DNA Repair; D016147:Genes, Tumor Suppressor; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53