[High risk factors lead to noscomial pulmonary infections caused by MRSA].
OBJECTIVE
To investigate major risk factors leading to death by noscomial MRSA pulmonary infections.


METHODS
The data of hospitalized patients diagnosed as noscomial MRSA pulmonary infections were sorted out and analyzed for recent three years.


RESULTS
Case mortality of 64 patients with noscomial MRSA pulmonary infections were 44%. Of these, 18 cases complicated fungi, 11 Klebsiella pneumoniae, 9 Pseudomonas maltophilia and 7 Enterococcus. Case mortality of fungi and Pseudomonas maltophilia were 67% and 61%, respectively. 23 cases had fever, 18 died (case mortality 78%) and 41 had no fever, 10 died (case mortality 24%) (chi 2 = 15.253, P < 0.005). The case mortality with reduction, normal and increase of leukocyte were 80%, 24% and 45%, respectively. The comparison between three groups had obvious significance (chi 2 = 12.554, P < 0.005) and the case mortality of leukocytopenia was higher than that of other two groups (chi 2 = 8.626, P < 0.005). The case mortality of hypoproteinemia was higher than that of the control group (chi 2 = 6.914, P < 0.01). The patients who developed fulminant lesions in liver, kidneys and lungs showed higher mortality rate.


CONCLUSIONS
Case mortality of noscomial pneumonia caused by MRSA is very high. In addition to common causes, underling diseases, leukocytopenia, malnutrition and complex infections are also risk factors of MRSA infection.
Wu
B
B
Department of Internal Medicine, 3rd Affiliated Hospital, Sun YatSen University of Medical Sciences, Guangzhou 510630, China.
Tang
Y
Y
Zhu
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003428:Cross Infection / Q000150:complications / Q000382:microbiology* / Q000401:mortality; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008171:Lung Diseases / Q000150:complications / Q000382:microbiology* / Q000401:mortality; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000382:microbiology / Q000401:mortality; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D015996:Survival Rate
D000900:Anti-Bacterial Agents