title: [Eosinophilic myositis in a 9 year old boy].
abstract: BACKGROUND
  Eosinophil infiltration of skeletal muscle is rare, but often no etiological factor can be identified and these are isolated eosinophilic myositis. They may be associated with parasite infections or drugs, or be features of rare systemic disorders of hypereosinophilia, such as the myalgia eosinophilia syndrome and the idiopathic hypereosinophilic syndrome. The eosinophilic myopathies should be distinguished from the commoner inflammatory myopathies such as polymyositis and dermatomyositis.
  
  
  METHODS
  A nine year old boy with slight motor clumsiness but normal psychomotor development and neurological findings. Laboratory findings showed slightly raised serum transaminases (SGOT 271, SGPT 157 UI/L), CPK 7517 UI/L and eosinophilia (707/mL). Investigations for myoglobin cysticercosis, trichinosis, hydatidosis and toxicariasis were negative. No parasites were found in the faeces. The gammaglobulins were normal. Anti smooth muscle, antinuclear and anti KLM antibodies were negative. Cardiological studies were normal. His father, mother and two siblings had normal results of laboratory tests. Muscle biopsy showed inflammatory myopathy with abundant eosinophils, no evidence of parasites, no alteration of membrane proteins: dystrophin, sarcoglycan and merosine. Two years later he remains asymptomatic, maintains raised muscle enzyme levels in all tests with figures for CPK between 3,065 and 9,616UI/L, and eosinophilia ranging between 634 and 1,026/mL. Corticosteroid treatment was tried but no response obtained.
  
  
  CONCLUSIONS
  We consider this to be a case of eosinophilic polymyositis which gives rise to many questions regarding etiopathogenesis, management and prognosis.
authors.affiliation: Servicio de Pediatría; Hospital General Universitario de Guadalajara, Guadalajara, 19002, España.
authors.forename: J L
authors.initials: JL
authors.lastname: Peña Segura
authors.forename: I
authors.initials: I
authors.lastname: Adrados
authors.forename: J M
authors.initials: JM
authors.lastname: Jiménez Bustos
authors.forename: A
authors.initials: A
authors.lastname: Cabello
authors.forename: J
authors.initials: J
authors.lastname: López Pisón
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D016603:Eosinophilia-Myalgia Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology; D013256:Steroids; D017211:Treatment Failure
chemical_list: D000893:Anti-Inflammatory Agents; D013256:Steroids
vernacular_title: Miositis eosinofílica en un niño de 9 años.