Choriocarcinoma of the gallbladder: treated with cisplatin-based chemotherapy.
A case of non-gestational choriocarcinoma, primary in the gallbladder, is described. Pathology showed a mixture of adenocarcinoma and choriocarcinoma. A Medline search for the last 10 years has shown no similar cases reported. The use of cisplatin-based chemotherapy to treat non-gestational choriocarcinoma has also not been described. This patient showed a rapidly progressive disease as described in other reported cases of non-gestational choriocarcinoma. However, cisplatin-based chemotherapy, in this patient, produced a partial response defined as significantly decreased beta-HCG titers (more than 50%), and with stable appearance or slightly improvement of hepatic metastasis and survival for 1 yr.
Wang
J C
JC
Division of Medical Oncology and Hematology, Brookdale University Hospital Medical Center, Brooklyn, NY 11212, USA. jcwang5@aol.com
Angeles
S
S
Chak
P
P
Platt
A B
AB
Nimmagadda
N
N
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000188:drug therapy* / Q000473:pathology; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D002945:Cisplatin / Q000008:administration & dosage; D018450:Disease Progression; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D005706:Gallbladder Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
D018997:Chorionic Gonadotropin, beta Subunit, Human; D005047:Etoposide; D002945:Cisplatin