Role of heparan sulfate in fibroblast growth factor signalling: a structural view.
Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR. Two recently determined crystal structures of FGF-FGFR-heparin complexes have provided new structural information on how heparin binds to FGF and FGFR, and lead to different models for receptor dimerisation.
Pellegrini
L
L
Department of Biochemistry, University of Cambridge, UK. luca@cryst.bioc.cam.ac.uk
D001665:Binding Sites; D018360:Crystallography, X-Ray; D016220:Fibroblast Growth Factor 1 / Q000737:chemistry; D005346:Fibroblast Growth Factors / Q000737:chemistry*; D006497:Heparan Sulfate / Q000737:chemistry*; D046911:Macromolecular Substances; D008958:Models, Molecular; D015394:Molecular Structure; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry; D051497:Receptor, Fibroblast Growth Factor, Type 2; D017468:Receptors, Fibroblast Growth Factor / Q000737:chemistry; D015398:Signal Transduction
D016220:Fibroblast Growth Factor 1; D005346:Fibroblast Growth Factors; D006497:Heparan Sulfate; D046911:Macromolecular Substances; D020794:Receptor Protein-Tyrosine Kinases; D051497:Receptor, Fibroblast Growth Factor, Type 2; D017468:Receptors, Fibroblast Growth Factor