title: Two successful pregnancies after conservative treatment of endometrial cancer and assisted reproduction.
abstract: OBJECTIVE
  To report successful pregnancies after conservative management of FIGO grade I adenocarcinoma of the endometrium.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  University-based assisted reproduction and oncology units.
  
  
  METHODS
  One patient who had two separate pregnancies.
  
  
  METHODS
  High-dose progestin (megestrol acetate) therapy for adenocarcinoma, followed by assisted reproduction with donor oocyte.
  
  
  METHODS
  Histologic evaluation of endometrium after megestrol acetate and at completion of childbearing, and successful pregnancies and deliveries.
  
  
  RESULTS
  The patient had complete resolution of adenocarcinoma with progestin therapy and successful delivery of two pregnancies after assisted reproduction.
  
  
  CONCLUSIONS
  Conservative management of International Federation of Gynecology and Obstetrics grade I adenocarcinoma of the endometrium allows preservation of childbearing.
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
authors.forename: M Patrick
authors.initials: MP
authors.lastname: Lowe
authors.forename: David
authors.initials: D
authors.lastname: Bender
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sood
authors.forename: William
authors.initials: W
authors.lastname: Davis
authors.forename: Craig H
authors.initials: CH
authors.lastname: Syrop
authors.forename: Joel I
authors.initials: JI
authors.lastname: Sorosky
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D036861:Delivery, Obstetric; D016889:Endometrial Neoplasms / Q000188:drug therapy*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019290:Megestrol Acetate / Q000627:therapeutic use*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted
chemical_list: D019290:Megestrol Acetate