title: [Immunological mechanism of human alpha-interferon gene therapy for treatment of melonoma].
abstract: OBJECTIVE
  To investigate the possibility of alpha-INF gene therapy for treatment of melonoma.
  
  
  METHODS
  An experimental model of fibroblast-mediated human alpha-IFN gene therapy was established for treatment of melonoma and the activity of NK and M phi was determined.
  
  
  RESULTS
  The NK and M phi activity was increasing significantly after the implantation of alpha-IFN secreted by cloning the fibroblast in vivo. Good therapeutic results could be achived if the NIH3T3-IFN-alpha+ cells were combined with the IL-2/AK.
  
  
  CONCLUSIONS
  The results has indicated that the fibroblast-mediated gene therapy could be good to use it for the treatment of human melonoma. More effective results could be achieved by using it in combination with IL-2.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Changzheng Hospital, 2nd Military Medical University, Shanghai 200003, China.
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Lin
authors.forename: X
authors.initials: X
authors.lastname: Cao
mesh_terms: D016475:3T3 Cells; D000818:Animals; D015316:Genetic Therapy; D006801:Humans; D016898:Interferon-alpha / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude
chemical_list: D016898:Interferon-alpha