title: [Ki67 and p53 in laryngeal epithelial lesions: correlations with risk factors].
abstract: Laryngeal carcinoma-the prototype of epithelial tumors in the head and neck region-has been the greatest source of information on the biological behavior of such neoplasms. Many Authors have suggested that smoke, and to a lesser extent alcohol, play a role in the genesis of this carcinoma although the exact biological mechanism for such involvement is still not clear. The present study analyzed two important biological indicators (p53 and Ki67) in benign and malignant epithelial lesions of the larynx in an attempt to obtain information on what mechanism correlates the risk factors with the neoplasm. In a group of 172 patients, an in vivo sampling of cells was taken during microlaryngoscopy. These cells were then tested using the immunocytochemical method and the results showed that the neoplastic tissue was significantly more positive to these markers than the pre-cancerous tissues and benign lesions. Moreover, there was also an interesting correlation between the degree of positivity to p53 and exposure to smoke, and to a lesser extent to alcohol, in the oncological patients. Together with other similar results found in the literature, these results hint at a possible explanation for the carcinogenic power of smoke in the larynx and, in general, in the upper respiratory-digestive tract.
authors.affiliation: Dipartimento delle Specialità Medico-Chirurgiche, Sezione di Otorinolaringologia, Università di Perugia.
authors.forename: G
authors.initials: G
authors.lastname: Leopardi
authors.forename: G
authors.initials: G
authors.lastname: Serafini
authors.forename: C
authors.initials: C
authors.lastname: Simoncelli
authors.forename: V
authors.initials: V
authors.lastname: Ludovini
authors.forename: L
authors.initials: L
authors.lastname: Pistola
authors.forename: G
authors.initials: G
authors.lastname: Altissimi
mesh_terms: D002277:Carcinoma / Q000737:chemistry* / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53
vernacular_title: Ki67 e p53 nelle lesioni epiteliali della laringe: correlazione con i fattori di rischio.