title: Fluorescence studies on PAMAM dendrimers interactions with bovine serum albumin.
abstract: Polyamidoamine (PAMAM) dendrimers (generation 3.5 and 4) interaction with bovine serum albumin (BSA) was studied. The intensity of intrinsic fluorescence of two tryptophan residues and a shift in wavelength of their emission maxima were chosen as indicators of protein conformational changes. It is shown that the generation 4 has a greater impact on spectral properties of serum albumin than generation 3.5.
authors.affiliation: Department of General Biophysics, University of Łódz, Banacha 12/16, 90-237 Łódz, Poland. aklajn@biol.uni.lodz.pl
authors.forename: B
authors.initials: B
authors.lastname: Klajnert
authors.forename: M
authors.initials: M
authors.lastname: Bryszewska
mesh_terms: D050091:Dendrimers; D011073:Polyamines / Q000378:metabolism*; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D012710:Serum Albumin, Bovine