[The effect of rhIL-11 on hematopoiesis of rhesus monkeys irradiated with 60Co gamma-rays].
OBJECTIVE
To study the therapeutic effect of recombinant human interleukin-11 (rhIL-11) on acute radiation sickness in monkeys.


METHODS
rhIL-11 (30, 60, 120 micrograms.kg-1.d-1, s.c., on days 0-13 after TBI) or vehicle was administered to rhesus monkeys irradiated with 3.0 Gy 60Co gamma-rays.


RESULTS
The nadirs of platelet count were significantly improved after treatment with rhIL-11. The duration of platelet and leukocyte numbers below 50% of their baseline values was shortened. Erythrocyte recovery was also accelerated. Semi-solid bone marrow cell culture demonstrated that rhIL-11 could stimulate monkey's bone marrow cell to form more CFU-MK, CFU-Mix, CFU-E and BFU-E in vitro, especially at the dose of 60 micrograms.kg-1.d-1. Histopathological observation revealed that bone marrow of the untreated controls showed large area of bleeding whereas that of the rhIL-11 treated monkeys was in active proliferation.


CONCLUSIONS
rhIL-11 can accelerate hematopoietic recovery of monkeys received 3.0 Gy total body gamma-rays irradiation.
Hao
J
J
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Luo
Q
Q
Xiong
G
G
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D001854:Bone Marrow Cells / Q000187:drug effects; D003037:Cobalt Radioisotopes; D004912:Erythrocytes / Q000187:drug effects; D015672:Erythroid Precursor Cells / Q000187:drug effects; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects*; D017370:Interleukin-11 / Q000627:therapeutic use*; D008253:Macaca mulatta; D011832:Radiation Injuries / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use
D003037:Cobalt Radioisotopes; D017370:Interleukin-11; D011994:Recombinant Proteins