[The effects of ozone and toxic air particles on airway function in mice].
We tested the hypothesis that exposures to particulate matter and ozone can produce asthma-like symptoms. Balb/c mice received a single intratracheal instillation of particulate matter and TiO2 or they were exposed to low concentration of ozone. We have established that exposure to particulate matter produces increased responsiveness to methacholine in mice. Exposure to ozone and TiO2 did not produce changes in respiratory mechanics. These data are spreading our understanding about mechanisms of environmental influence on airways.
Hots
T Iu
TIu
P.L. Shupik Medical Academy for Postgraduate Training, Kiev.
D000393:Air Pollutants / Q000494:pharmacology*; D000818:Animals; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology*; D016535:Bronchial Hyperreactivity / Q000209:etiology*; D001985:Bronchial Provocation Tests; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D010126:Ozone / Q000494:pharmacology*; D010316:Particle Size; D012129:Respiratory Function Tests; D014025:Titanium / Q000494:pharmacology
D000393:Air Pollutants; D008688:Methacholine Compounds; C009495:titanium dioxide; D010126:Ozone; D014025:Titanium
Vplyv ozonu ta toksychnykh chastok povitria na dykhal'ni shliakhy mysheĭ.