title: Synovial response to intra-articular metal debris: Implications for anterior cruciate ligament reconstruction.
abstract: OBJECTIVE
  Intra-articular metal debris is occasionally seen after completion of an endoscopic anterior cruciate ligament reconstruction. The purpose of this study was to examine the tissue response to intra-articular stainless steel metal debris in order to better understand its role in the inflammatory process.
  
  
  METHODS
  Animal case control study.
  
  
  METHODS
  Metal filings created from a Beath pin were injected into 10 rabbit knees. The opposite knee of each rabbit was used as a control. The animals were killed at 4 weeks. The knee joints were fixed, sectioned, stained, and examined under light microscopy.
  
  
  RESULTS
  Mild to moderate levels of synovial proliferation were observed in all knees injected with metal particles. There was no evidence of phagocytosis of the metal particles, nor was there any evidence of an inflammatory response. No articular cartilage damage was observed as a result of the metal debris.
  
  
  CONCLUSIONS
  We believe that the few particles of stainless steel that may be produced during the reaming process in anterior cruciate ligament reconstruction do not pose a significant risk of inciting an inflammatory reaction or cause articular cartilage damage within the knee joint.
authors.affiliation: Louisiana State University Knee and Sports Medicine Fellowship, Lake Charles, Louisiana, USA. Gregory.B.Maletis@kp.org
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Maletis
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Samuelson
authors.forename: David
authors.initials: D
authors.lastname: Drez
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D001858:Bone Nails; D002358:Cartilage, Articular / Q000293:injuries / Q000473:pathology; D007249:Inflammation / Q000473:pathology; D007719:Knee Joint / Q000473:pathology* / Q000601:surgery*; D023421:Models, Animal; D011817:Rabbits; D013193:Stainless Steel / Q000009:adverse effects*; D013583:Synovial Membrane / Q000473:pathology*
chemical_list: D013193:Stainless Steel