title: Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis.
abstract: We demonstrated in vitro that YycG-YycF of Bacillus subtilis constitutes a two-component system and shows a specificity of the sensor protein for the cognate phosphorylation partner. Based on inhibition of such an autophosphorylation of YycG, we searched imidazole and zerumbone derivatives to identify the antibacterial agents such as NH125, NH126, NH127, and NH0891.
authors.affiliation: Department of Agricultural Chemistry, Kinki University, Nara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Kitayama
authors.forename: S
authors.initials: S
authors.lastname: Minagawa
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.forename: R
authors.initials: R
authors.lastname: Utsumi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D000071677:Histidine Kinase; D007093:Imidazoles / Q000494:pharmacology; D016297:Mutagenesis, Site-Directed; D010766:Phosphorylation / Q000187:drug effects; D016133:Polymerase Chain Reaction; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D012717:Sesquiterpenes / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004791:Enzyme Inhibitors; D007093:Imidazoles; D047428:Protein Kinase Inhibitors; D012717:Sesquiterpenes; D011494:Protein Kinases; D000071677:Histidine Kinase