Exploring the protein interactome using comprehensive two-hybrid projects.
Large-scale two-hybrid projects were used in an approach to examine protein-protein interactions. Despite the various limitations of this approach, these projects revealed a wealth of novel interactions, and the protein interactome may be much larger than expected.
Ito
T
T
Division of Genome Biology, Cancer Research Institute, Kanazawa University, Japan. titolab@kenkroku.kanazawa-u.ac.jp
Chiba
T
T
Yoshida
M
M
D019295:Computational Biology / Q000379:methods*; D023281:Genomics / Q000379:methods; D025941:Protein Interaction Mapping / Q000379:methods*; D004718:Saccharomycetales / Q000235:genetics; D012984:Software; D020798:Two-Hybrid System Techniques