title: Reactive coupling of poly(ethylene glycol) on electroactive polyaniline films for reduction in protein adsorption and platelet adhesion.
abstract: Poly(ethylene glycol) (PEG)-coupled polyaniline (PANI) film surfaces were prepared by incorporating the chlorinie end-capped methoxy PEG (mPEGCl) of molecular weight of about 2000 onto the emeraldine (EM) base form of PANI via N-alkylation. The microstructure and composition of the mPEG-coupled PANI (mPEG-c-PANI) surfaces were characterized by atomic force microscopy, contact angle measurement and X-ray photoelectron spectroscopy. The concentration of surface-coupled mPEG increased with the increase in concentration of the mPEGCl solution. The mPEG-c-PANI film surfaces exhibited enhanced ability to repel protein adsorption, with only an moderate reduction in their electrical conductivity. The mPEG-c-PANI surface with a high concentration of coupled mPEG also exhibited good resistance towards platelet adhesion.
authors.affiliation: Department of Chemical Engineering, National University of Singapore, Singapore.
authors.forename: Fu
authors.initials: F
authors.lastname: Zhang
authors.forename: E T
authors.initials: ET
authors.lastname: Kang
authors.forename: K G
authors.initials: KG
authors.lastname: Neoh
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: K L
authors.initials: KL
authors.lastname: Tan
mesh_terms: D000327:Adsorption; D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D010973:Platelet Adhesiveness / Q000502:physiology*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000814:Aniline Compounds; D020099:Coated Materials, Biocompatible; D011506:Proteins; C416807:polyaniline; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols