Pregnancy outcome after maternal poisoning with brodifacoum, a long-acting warfarin-like rodenticide.
BACKGROUND
Brodifacoum is a potent warfarin-like anticoagulant used in many rat-poisoning products. Its availability has led to several reported human ingestions, none previously reported in pregnancy.


METHODS
A woman presented at 22 weeks' gestation in hemorrhagic diathesis, attributed to the ingestion of rat poison containing brodifacoum several days earlier. Aggressive vitamin K therapy controlled the maternal coagulopathy, and no fetal hemorrhage was observed by sonography. Her subsequent prenatal course and delivery were unremarkable, and she was delivered of a healthy infant, who has remained well for at least 1 year.


CONCLUSIONS
In this patient, brodifacoum ingestion in pregnancy caused substantial maternal hemorrhage, but no fetal hemorrhage or teratogenic effects were observed.
Zurawski
J M
JM
University of Cincinnati College of Medicine, Department of Obstetrics and Gynecology, OH, USA.
Kelly
E A
EA
D015110:4-Hydroxycoumarins / Q000008:administration & dosage / Q000506:poisoning*; D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000139:chemically induced*; D011256:Pregnancy Outcome; D012378:Rodenticides / Q000008:administration & dosage / Q000506:poisoning*; D013406:Suicide, Attempted
D015110:4-Hydroxycoumarins; D012378:Rodenticides; C013418:bromfenacoum