High variability of HTLV-I in a remote population of Gabon as compared to that of a similar population of French Guiana.
An anomalous high frequency of ATL was observed in a remote 'noir maroons' village of French Guiana. Since it is not clear if HTLV-I is responsible for different frequencies of disease in different geographical areas, we undertook a comparison of the population with a similar one located in Gabon. We found a much higher degree of gp46 surface envelope glycoprotein sequence conservation in the Guianese village than in the Gabonese one.
Moynet
D
D
Immunologie Moléculaire et Parasitologie, Université Bordeaux2, France. daniel.moynet@immol.u-bordeaux2.fr
Pouliquen
J F
JF
Londos-Gagliardi
D
D
Buigues
R P
RP
Moreau
J F
JF
Bedjabaga
I
I
Georges
M C
MC
Talarmin
A
A
Joubert
M
M
Fleury
H
H
Vincendeau
P
P
Guillemain
B
B
D001483:Base Sequence; D017124:Conserved Sequence; D004279:DNA, Viral; D005260:Female; D005616:French Guiana / Q000453:epidemiology; D005681:Gabon / Q000453:epidemiology; D015686:Gene Products, env / Q000235:genetics; D014644:Genetic Variation; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics; D016415:Sequence Alignment
D004279:DNA, Viral; D015686:Gene Products, env; D015682:Retroviridae Proteins, Oncogenic; C055266:gp46 protein, Human T-cell leukemia virus type I