High-resolution analysis of engineered type I collagen nanofibers by electron microscopy.
Collagen nanofibers were generated at ambient temperature and pressure by electrospinning a 1 wt% solution of type I collagen and polyethylene oxide. Products were imaged with high-resolution scanning electron microscopy (HRSEM) at medium (approximately 30,000 x) and high magnifications (approximately 100,000 x) and with transmission electron microscopy (TEM). The capacity to produce collagen nanofibers may lead to the generation of extracellular matrix-based fabrics with applications in the fields of wound healing and tissue engineering.
Huang
L
L
Department of Surgery, Emory University, Atlanta, Georgia 30322, USA.
Apkarian
R P
RP
Chaikof
E L
EL
D024042:Collagen Type I / Q000302:isolation & purification / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D009210:Myofibrils / Q000648:ultrastructure; D011092:Polyethylene Glycols
D024042:Collagen Type I; D011092:Polyethylene Glycols