[Serum soluble tumor necrosis factor alpha receptor (s-TNF-alpha R) and acute phase proteins as factors of a disease activity (and also as prognostic factors?) in patients with malignant lymphomas].
It was found that in neoplastic disorders levels of sTNF-alpha R and acute phase proteins are elevated and correlate with disease activity and poor prognosis. The aim of the study was to determine levels of sTNF-alpha R and acute phase proteins in patients with lymphoma at presentation and after treatment and compare with healthy individuals. Serum concentration of sTNF-alpha R was estimated by ELISA method, fibrinogen and haptoglobin by nephelometric method in 46 lymphoma patients and in 14 healthy individuals. Mean sTNF-alpha R concentration in lymphoma group was statistically significantly higher than in healthy individuals (p = 0.00057) and in patients with complete remission (CR) (p = 0.024). Mean concentration of fibrinogen and haptoglobin was significantly statistically higher at presentation of lymphoma than in CR (p = 0.0001, p = 0.0001). We found the correlation between the mean concentration of sTNF-alpha R, fibrinogen and haptoglobin at presentation of lymphoma. There was no difference in the survival time in patients with higher concentration of sTNF-alpha R. Our data indicate the important role of the elevated concentration of sTNF-alpha R, fibrinogen and haptoglobin as factors of disease activity in lymphoma patients but they do not correlate with disease's prognosis.
Kapelko-Słowik
K
K
Katedra i Klinika Hematologii i Chorób Rozrostowych AM we Wrocławiu.
Urbaniak-Kujda
D
D
Jaźwiec
B
B
Tomaszewska-Toporska
B
B
Kuliczkowski
K
K
D000208:Acute Disease; D000209:Acute-Phase Proteins / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D000209:Acute-Phase Proteins; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha
Rozpuszczalny receptor dla czynnika martwicy nowotworów alfa(sTNF-alfaR) i białka ostrej fazy jako mierniki aktywności choroby (czy takze--wskaźniki prognostyczne?) u pacjentów z chłoniakami złośliwymi.