title: [Study on prevention and treatment of middle and aged women diabetes with kidney deficiency and bone metabolic disturbance].
abstract: OBJECTIVE
  To Study the therapeutic effect of Chinese herbal medicine (CHM) for supplementing Qi, activating blood circulation and tonifying Kidney on prevention and treatment of middle and aged women diabetes with Kidney Deficiency and bone metabolic disturbance.
  
  
  METHODS
  Clinical observation was taken in 52 patients, who were divided into two groups, the control group (treated with hypoglycemic agent alone) and the treated group (treated with hypoglycemic agent and CHM).
  
  
  RESULTS
  Before treatment, patients of both groups showed obvious higher blood alkaline phosphatase, beta 2-microglobulin (beta 2-MG) level, urinary beta 2-MG, calcium and phosphorus level, but lower serum estradiol level than those in normal subjects. After 3 months' treatment, no apparent change on serum estradiol level was observed, but other parameters were all lowered obviously in the two groups, the changes revealed more obvious in the treated group. The symptoms of Kidney Deficiency, such as lumbodorsal pain, general fatigue, palpitation and vertigo, were improved after treatment, and the improvement was also more obvious in the treated group.
  
  
  CONCLUSIONS
  CHM for supplementing Qi, activating blood circulation and tonifying Kidney was effective in improving Kidney Deficiency and mineral substance loss of bone in middle and aged women diabetes patients. The CHM and western drugs may acted synergistically.
authors.affiliation: Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhu
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000368:Aged; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D016711:Yang Deficiency / Q000188:drug therapy / Q000517:prevention & control; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D001613:beta 2-Microglobulin; D004958:Estradiol