[Expression of basic fibroblastic growth factor and microvessel density in endometrial carcinoma].
OBJECTIVE
To investigate the relation of basic fibroblastic growth factor (bFGF) and microvessel density (MVD) with endometrial carcinoma.


METHODS
A total of 66 specimens of endometrial carcinoma were evaluated by immunohistochemical technique with polyclonal antibody against bFGF. The microvessels were highlight by immunohistologically staining to detect factor VIII-related antigen. The area of the deepest myometrial invasion was selected for staining. Ninteen specimens of uterine prolapse were used for control.


RESULTS
Expression of bFGF was significantly correlated with tumor grade (P < 0.01). MVD was positively correlated with age, tumor grade and myometrial invasion (P < 0.01, respectively). MVD was significantly correlated with expression of bFGF (P < 0.01). Patients with bFGF strong expression and high MVD (> or = 9.4) had worse prognosis (P < 0.01, respectively).


CONCLUSIONS
bFGF plays important role in angiogenesis in endometrial carcinoma. Expression of bFGF and MVD could be used as prognostic factors for survival in endometrial carcinoma.
Bai
X
X
Department of Obstetrics and Gynecology, General Hospital, Tianjin Medical University, Tianjin 300052, China.
Mi
R
R
D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000098:blood supply* / Q000737:chemistry / Q000473:pathology; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D006801:Humans; D008833:Microcirculation; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000209:etiology*; D015996:Survival Rate
D016222:Fibroblast Growth Factor 2