title: [Fusion of MRI, fMRI and intraoperative MRI data. Methods and clinical significance exemplified by neurosurgical interventions].
abstract: The aim of this work was to realize and clinically evaluate an image fusion platform for the integration of preoperative MRI and fMRI data into the intraoperative images of an interventional MRI system with a focus on neurosurgical procedures. A vertically open 0.5 T MRI scanner was equipped with a dedicated navigation system enabling the registration of additional imaging modalities (MRI, fMRI, CT) with the intraoperatively acquired data sets. These merged image data served as the basis for interventional planning and multimodal navigation. So far, the system has been used in 70 neurosurgical interventions (13 of which involved image data fusion--requiring 15 minutes extra time). The augmented navigation system is characterized by a higher frame rate and a higher image quality as compared to the system-integrated navigation based on continuously acquired (near) real time images. Patient movement and tissue shifts can be immediately detected by monitoring the morphological differences between both navigation scenes. The multimodal image fusion allowed a refined navigation planning especially for the resection of deeply seated brain lesions or pathologies close to eloquent areas. Augmented intraoperative orientation and instrument guidance improve the safety and accuracy of neurosurgical interventions.
authors.affiliation: Klinik und Poliklinik für Diagnostische Radiologie, Universitätsklinikum Leipzig, Liebigstr. 20a, 04103 Leipzig. moche@medizin.uni-leipzig.de
authors.forename: M
authors.initials: M
authors.lastname: Moche
authors.forename: H
authors.initials: H
authors.lastname: Busse
authors.forename: C
authors.initials: C
authors.lastname: Dannenberg
authors.forename: T
authors.initials: T
authors.lastname: Schulz
authors.forename: A
authors.initials: A
authors.lastname: Schmitgen
authors.forename: C
authors.initials: C
authors.lastname: Trantakis
authors.forename: D
authors.initials: D
authors.lastname: Winkler
authors.forename: F
authors.initials: F
authors.lastname: Schmidt
authors.forename: T
authors.initials: T
authors.lastname: Kahn
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000295:instrumentation; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D002540:Cerebral Cortex / Q000473:pathology / Q000601:surgery; D003199:Computer Systems; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D013238:Stereotaxic Techniques / Q000295:instrumentation; D025321:Surgery, Computer-Assisted / Q000295:instrumentation*
vernacular_title: Fusion von MRT-, fMRT- und intraoperativen MRT-Daten. Methode und klinische Bedeutung am Beispiel neurochirurgischer Interventionen.