title: Human ERMAP: an erythroid adhesion/receptor transmembrane protein.
abstract: A human cDNA and gene encoding for human ERMAP, a putative erythroid transmembrane adhesion/receptor protein, is reported. The predicted protein is made up of 475 amino acids and shares high homology with the murine ERMAP (73% identity and 14% conservative changes). Human Ermap is highly expressed in erythroid tissues and the protein localizes to the plasma membrane, particularly in sites of cell contact, and "cytoplasmic bodies." The extracellular segment contains one IgV fold that shares high homology with the butyrophilin family of milk proteins, autoantigens, and avian blood group antigens. In the intracellular region, there is a conserved B30.2 domain that is encoded by a single exon and is highly homologous with a similar domain in a diverse group of proteins, including butyrophilin, pyrin, and MID 1. The human Ermap gene is composed of 11 exons spanning 19 kb on chromosome 1p34.
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Faculty of Health Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Su
authors.forename: C T
authors.initials: CT
authors.lastname: Gordon
authors.forename: T Z
authors.initials: TZ
authors.lastname: Ye
authors.forename: A C
authors.initials: AC
authors.lastname: Perkins
authors.forename: D H
authors.initials: DH
authors.lastname: Chui
mesh_terms: D000595:Amino Acid Sequence; D001789:Blood Group Antigens; D000071797:Butyrophilins; D002451:Cell Compartmentation; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D018076:DNA, Complementary; D015672:Erythroid Precursor Cells; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014018:Tissue Distribution
chemical_list: D001789:Blood Group Antigens; D000071797:Butyrophilins; D018076:DNA, Complementary; D008565:Membrane Proteins; C472715:scianna antigens