[The role of stimulation parameters of sympathetic nerves in regulation of microvessel tone in the rat stomach].
Maximal responses to splanchnic nerve stimulation occurred in rats at the pulse width 0.5-1.0 Ohms regardless of the frequency. Peak constriction of arterioles and venules occurred at a 3-4-sec burst duration and 1-2-sec interval. Adrenergic blockade abolished the vasoconstriction in response to continuous nerve stimulation. However, the responses persisted in high-frequency burst stimulation, suggesting an involvement of non-adrenergic co-transmitter release. Thereupon, an efficient control of microvascular tone can be achieved by grouping the pulses into bursts or by an increase of the burst rate or duration.
Lentsman
M V
MV
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, 199034, Nab. Makarova, 6, Russia.
Polenov
S A
SA
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001160:Arterioles; D004558:Electric Stimulation; D008833:Microcirculation; D018715:Microscopy, Video; D009119:Muscle Contraction; D009129:Muscle Tonus; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013153:Splanchnic Nerves / Q000502:physiology*; D013270:Stomach / Q000098:blood supply*; D014699:Venules
D000317:Adrenergic alpha-Antagonists
Rol' parametrov stimuliatsii simpaticheskikh nervov v reguliatsii tonusa mikrososudov zheludka krys.