title: The prescription pattern of oral nitrates in coronary artery disease. Appropriateness and cost considerations.
abstract: OBJECTIVE
  To evaluate the prescription patterns of oral nitrates in terms of appropriateness and cost in a community setting.
  
  
  METHODS
  A period prevalence, descriptive, applied study. Data including age, gender, type of medication, dosage and cost were extracted from the database of the largest health maintenance organisation (HMO) in Israel. The study population included enrollees over 35 years of age who received oral nitrates at least once during the 12-month study period.
  
  
  RESULTS
  Oral nitrates were prescribed for 8007 patients (mean age 72.85+/-9.59 years, male:female ratio 1:1). A total of 52,694 prescriptions were issued for 56,553 medications, of these 88.1% for mononitrates, which constituted 95% of the annual cost for patients and the HMO. The mean prescribed daily dose for the various drugs ranged from 30% less than to 50% more than the recommended dose. Combination therapy with at least two nitrates, which is not the recommended treatment, was given to 5% of the patients. The recommended alternative treatment will alleviate the financial burden for providers and patients.
  
  
  CONCLUSIONS
  Improved prescription habits can provide enhanced quality as well as cost savings for patients and providers.
authors.affiliation: Department of Health Policy and Management, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. reuveni@bgumail.bgu.ac.il
authors.forename: H
authors.initials: H
authors.lastname: Reuveni
authors.forename: E E
authors.initials: EE
authors.lastname: Aviram
authors.forename: A
authors.initials: A
authors.lastname: Elhayani
authors.forename: M
authors.initials: M
authors.lastname: Lifshitz
authors.forename: R
authors.initials: R
authors.lastname: Peled
authors.forename: N
authors.initials: N
authors.lastname: Galai
authors.forename: M
authors.initials: M
authors.lastname: Sherf
authors.forename: E
authors.initials: E
authors.lastname: Paran
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000188:drug therapy*; D003365:Costs and Cost Analysis; D003692:Delayed-Action Preparations / Q000191:economics; D011307:Drug Prescriptions / Q000191:economics* / Q000706:statistics & numerical data; D004363:Drug Utilization; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives / Q000191:economics / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000191:economics / Q000627:therapeutic use; D010818:Practice Patterns, Physicians' / Q000191:economics* / Q000706:statistics & numerical data; D014665:Vasodilator Agents / Q000191:economics / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D009566:Nitrates; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate