title: Favourable long-term outcome by repeated percutaneous coronary revascularization in diabetic haemodialysis patients.
abstract: BACKGROUND
  Diabetic haemodialysis patients have a high prevalence of coronary events and very high mortality rates. Percutaneous coronary intervention has become a well-established and routine procedure for coronary revascularization. This study investigated the long-term outcome of multiple repeated interventions in diabetic haemodialysis patients with coronary artery disease.
  
  
  METHODS
  A retrospective study compared 37 type II diabetic haemodialysis patients with coronary artery disease and 26 non-diabetic patients matched for age, angiographic morphology, and devices of percutaneous intervention. All patients had undergone successful percutaneous intervention prior to enrollment. Percutaneous interventions were repeated in the event of restenosis or the development of a de novo lesion.
  
  
  RESULTS
  Diabetic and non-diabetic patients were similar in terms of the number of follow-up angiograms (2.3+/-1.6 vs 2.4+/-1.5/patient) and interventions (2.2+/-1.4 vs 2.2+/-1.5/patient), incidence of target lesion revascularization (85 vs 82%), and number of de novo lesions (15 vs 17%). The cumulative survival rates after the initial percutaneous intervention were similar in the groups (42% vs 31% at 80 months). Cardiac death occurred in 33% of diabetic patients and 42% of non-diabetic patients. Repeated intervention (regression coefficient=16.0, P<0.001) and a lower left ventricular ejection fraction (regression coefficient=-12.9, P=0.047) were determined for the important clinical factors associated with the survival duration after initial coronary intervention.
  
  
  CONCLUSIONS
  Multiple repeated percutaneous interventions reduce the long-term mortality of diabetic and non-diabetic haemodialysis patients with coronary artery disease similarly. Multiple repeated percutaneous coronary interventions are a viable option for controlling myocardial ischaemia and improving the long-term outcome in high-risk diabetic haemodialysis patients.
authors.affiliation: Third Department of Internal Medicine, Division of Nephrology, Toho University Ohashi Hospital, Ohashi 2-17-6, Meguro-Ku, Tokyo 183-8515, Japan. hiroki@oha.toho-u.ac.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hase
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Joki
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.forename: Taro
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Yuri
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Fukazawa
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Imamura
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Nakamura
authors.forename: Tetsu
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000401:mortality; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D006435:Renal Dialysis / Q000379:methods*; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate