Application of an in vivo brain microdialysis technique to studies of drug transport across the blood-brain barrier.
There is a wide range of methods available for studying the transport of drugs across the blood-brain barrier (BBB) which is equipped with several systems to transport drugs as well as endogenous nutrients and waste products. The in vivo brain microdialysis technique, which allows direct sampling of the brain interstitial fluid (ISF), is a powerful means of characterizing influx and efflux transport across the BBB. In this paper, we review our results from the successful application of this technique to BBB drug transport studies. The drugs investigated include novel and CNS-active peptides, some agents that are actively removed from the brain ISF across the BBB, and a brain-directed prodrug.
Deguchi
Y
Y
Department of Biopharmaceutics, Hokkaido College of Pharmacy, Otaru-shi, Japan. deguchi@hokuyakudai.ac.jp
Morimoto
K
K
D001692:Biological Transport / Q000187:drug effects* / Q000502:physiology*; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000378:metabolism*; D006801:Humans; D017551:Microdialysis / Q000379:methods*