title: [Changes in the afferent activity of the vagus nerve and the rectal temperature in rats following Escherichia coli endotoxin administration].
abstract: In anaesthetised rats, i.p. administration of the Echerichia coli lipopolysaccharide in doses 5 mcg/kg (LPS) increased afferent activity of the cervical vagus, whereas 100 and 1000 mcg/kg doses inhibited the afferent discharges. Pyrogen-free saline (PFS) did not alter the activity. Rectal temperature (RT) was decreased by the PFS and by large doses of the LPS. Sodium salicylate administration prevented the effects.
authors.affiliation: Institute of Physiology, National Acad. Sci., Minsk, 220072, Akademicheskaya St., 28, Belarus.
authors.forename: V I
authors.initials: VI
authors.lastname: Lapsha
authors.forename: T M
authors.initials: TM
authors.lastname: Lukashenko
authors.forename: L N
authors.initials: LN
authors.lastname: Utkina
authors.forename: V N
authors.initials: VN
authors.lastname: Gurin
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects*; D004926:Escherichia coli; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D015213:Neuroimmunomodulation; D051381:Rats; D017208:Rats, Wistar; D012980:Sodium Salicylate / Q000494:pharmacology; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; C440499:lipopolysaccharide, Escherichia coli O111 B4; D012980:Sodium Salicylate
vernacular_title: Izmeneniia afferentnoĭ impul'satsii v bluzhdaiushchikh nervakh i rektal'noĭ temperatury u krys posle vvedeniia éndotoksina Escherichia coli.