title: Immunocytochemical localization of antigens recognized by asymptomatic microfilaremic patient's antisera in microfilariae of Wuchereria bancrofti.
abstract: Ultrathin sections of microfilariae of Wuchereria bancrofti embedded in hydrophilic resin were incubated with sera from patients, using antisera from asymptomatic microfilaremic patients with different microfilarial densities [1-100 microfilariae (mf)/ml, 101-500 mf/ml, > 1,000 mf/ml]. All groups studied showed reactivity against relevant epitopes in all tissues of microfilariae of W. bancrofti, instead of being localized in a specific nematode region, although the number of colloidal per square micron was inversely proportional to the microfilaremia. Such results confirm data obtained by other authors and indicate a possible role for the humoral response in the mechanism for the destruction of circulating microfilariae.
authors.affiliation: Departamento de Patologia e Biologia Celular, Centro de Pesquisas Aggeu Magalhães, Universidade Federal de Pernambuco, Recife, CEP, Brazil.
authors.forename: L C
authors.initials: LC
authors.lastname: Alves
authors.forename: F A
authors.initials: FA
authors.lastname: Brayner
authors.forename: L F
authors.initials: LF
authors.lastname: Silva
authors.forename: J
authors.initials: J
authors.lastname: Miranda
authors.forename: A
authors.initials: A
authors.lastname: Rocha
authors.forename: C A
authors.initials: CA
authors.lastname: Peixoto
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000947:Antigens, Helminth / Q000032:analysis*; D004605:Elephantiasis, Filarial / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D008842:Microfilariae / Q000276:immunology; D014958:Wuchereria bancrofti / Q000254:growth & development / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth