title: Tc-99m MDP, thallium-201 chloride and Tc-99m MAG3 renal uptake in subacute and chronic radiation nephritis compared.
abstract: The authors present a comparison of the findings for thallium-201 (Tl-201), Tc-99m MAG3 and Tc-99m MDP in subacute and chronic radiation nephritis in a 9-yr-old boy who was treated by radiation therapy for alveolar rhabdomyosarcoma of the left chest wall by a radiation port that partially included the left kidney. Tl-201 imaging three and six months later showed a cortical defect in the left kidney due to radiation nephritis. Tc-99m MDP scan showed increased uptake on both occasions, but more marked in the subacute period than in the chronic period. Tc-99m MAG3 showed decreased concentration and increased cortical retention three months later. Six months after the radiation therapy, a cortical defect corresponding to the cortical area that showed increased parenchymal retention was more prominent in the Tc-99m MAG3 scan. In the present case, Tc-99m MDP, Tl-201 and Tc-99m MAG3 findings may provide useful information for understanding pathophysiological damage in the kidney after radiation.
authors.affiliation: Department of Nuclear Medicine, Dokuz Eylul University, Medical School, Izmir, Turkey. berna.degirmenci@deu.edu.tr
authors.forename: B
authors.initials: B
authors.lastname: Degirmenci
authors.forename: K
authors.initials: K
authors.lastname: Uysal
authors.forename: R
authors.initials: R
authors.lastname: Bekis
authors.forename: R
authors.initials: R
authors.lastname: Cetingoz
authors.forename: G C
authors.initials: GC
authors.lastname: Kaya
authors.forename: H
authors.initials: H
authors.lastname: Durak
mesh_terms: D002648:Child; D002908:Chronic Disease; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008297:Male; D009393:Nephritis / Q000000981:diagnostic imaging* / Q000378:metabolism; D011832:Radiation Injuries / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D018232:Rhabdomyosarcoma, Alveolar / Q000532:radiotherapy; D012272:Ribs; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics*; D017263:Technetium Tc 99m Mertiatide / Q000493:pharmacokinetics*; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D017263:Technetium Tc 99m Mertiatide; D013669:Technetium Tc 99m Medronate