title: Once we know all the radiobiology we need to know, how can we use it to predict space radiation risks and achieve fame and fortune?
abstract: It has been over 40 years since occupational radiation exposures to NASA's astronauts began and more than 300 individuals have been exposed to low and intermediate doses of trapped protons and galactic cosmic rays (GCR). The International Space Station (ISS) will add substantially to this number and significantly increase average lifetime doses. We review these exposures in this report. After many years of investigation, the method used to assess risk have not changed significantly. However, molecular biology and genetics have made enormous progress in establishing the mechanisms of cancer formation, damage to the central nervous system, and individual variation in sensitivity to radiation. We discuss critical questions and possible new approaches to the prediction of risk from space radiation exposures. Experimental models can lead to testable theories that along with extensive biophysical and informatics approaches, will lead to fame and fortune by allowing for accurate projections of astronaut risks and for the development of biological countermeasures.
authors.affiliation: NASA, Johnson Space Center, Houston, TX 77058, USA.
authors.forename: F A
authors.initials: FA
authors.lastname: Cucinotta
mesh_terms: D000337:Aerospace Medicine; D018480:Astronauts; D002468:Cell Physiological Phenomena / Q000528:radiation effects; D003359:Cosmic Radiation; D004307:Dose-Response Relationship, Radiation; D005118:Extraterrestrial Environment; D006801:Humans; D018499:Linear Energy Transfer; D008452:Maximum Allowable Concentration; D008962:Models, Theoretical; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology; D016273:Occupational Exposure / Q000592:standards*; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000295:instrumentation; D011853:Radiobiology / Q000379:methods / Q000592:standards / Q000639:trends*; D018570:Risk Assessment; D013026:Space Flight / Q000592:standards / Q000639:trends*