title: [Clinical study on treatment of chronic idiopathic thrombocytopenic purpura by Decoction of Nourishing Blood and Eliminating Purpura].
abstract: OBJECTIVE
  To observe the clinical effect of treatment of chronic idiopathic thrombocytopenic purpura (CITP) by Decoction of Nourishing Blood and Eliminating Purpura (DNBEP), and study the possible mechanism.
  
  
  METHODS
  Effect of 55 patients of CITP in treatment group treated by DNBEP and 22 patients in the control group treated by Antaisu were observed and compared. Their immunologic indexes were determined for exploring the mechanism.
  
  
  RESULTS
  The markedly effective, improved and total effective rate of the treatment group were 32.7%, 20.0% and 87.3%, while those of the control group were 4.5%, 9.1% and 45.5% respectively, the difference between the two groups was significant (P < 0.001). The effect of the treatment group was better than the control group in platelet count restoring, hemorrhagic symptoms improving and effect initiating, P < 0.01. Immunologic test showed that the humoral and cell immune function as well as platelet function were abnormal in CITP patients. These functions were improved after treatment, and the effectiveness of the treatment group was significantly superior to that of the control group.
  
  
  CONCLUSIONS
  DNBEP is reliable in treating CITP clinically. Its mechanism might be better due to its selective suppression of humoral immune function, bi-directional regulation of cell immune function and recovery of platelet function.
authors.affiliation: Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing (100091).
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: A
authors.initials: A
authors.lastname: Zhou
authors.forename: R
authors.initials: R
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy* / Q000276:immunology
chemical_list: D004365:Drugs, Chinese Herbal