[Significance of platelet CD62p, CD63 assessment in type 2 diabetes mellitus patients with blood stasis].
OBJECTIVE
To study the relationship between blood stasis and platelet activation and the influential factors on the latter in type 2 diabetes mellitus (DM) patients.


METHODS
Platelet CD62p, CD63 expressions were determined in 30 patients of type 2 DM with blood stasis, 27 patients of type 2 DM without blood stasis and 20 normal controls by flow cytometry.


RESULTS
CD62p, CD63 levels were significantly higher in type 2 DM with blood stasis group than that without blood stasis group and in normal controls. CD62p was positively correlated with CD63, while positive correlation existed between HbA1c, LDL-C and CD62p in DM patients with blood stasis.


CONCLUSIONS
The increased level of platelet activation was the primary molecular basis in type 2 DM. It was important to perform the Syndrome Differentiation of blood stasis and treatment of activating blood circulation to remove blood stasis in type 2 DM.
Jiang
Z
Z
General Hospital of Jinan Military Region, Jinan (250031).
Zhang
S
S
Kou
T
T
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30
D015703:Antigens, CD; C554586:CD63 protein, human; D015815:Cell Adhesion Molecules; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30