Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs.
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied. The acute gastric ulcer models used were pylorus ligation, indomethacin, ethanol and histamine induced acute gastric ulcers. Chronic gastric ulcers were induced using acetic acid and duodenal ulcers by cysteamine hydrochloride. Oxytocin showed significant antisecretory and antiulcer activity in pylorus ligated rats. Similarly oxytocin reduced the ulcer index in histamine induced gastric ulcers in guinea pigs and cysteamine induced duodenal ulcers in rats. The antiulcer and antisecretory effect was comparable to that of ranitidine (50mg/kg, i.p) though less in intensity. However, it did not show any gastric cytoprotective effect in ethanol and indomethacin induced ulcer models but ranitidine showed protection (p<0.05) in later model. Oxytocin enhanced gastric ulcer healing in acetic acid induced chronic gastric ulcer model. The reversal of oxytocin effect by atosiban, an oxytocin receptor antagonist indicates a role for oxytocin receptors. The antiulcer activity of oxytocin can be attributed to its antisecretory effect.
Asad
M
M
Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry, India.
Shewade
D G
DG
Koumaravelou
K
K
Abraham
B K
BK
Vasu
S
S
Ramaswamy
S
S
D019342:Acetic Acid / Q000633:toxicity; D000208:Acute Disease; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002908:Chronic Disease; D003543:Cysteamine / Q000633:toxicity; D004195:Disease Models, Animal; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004386:Duodenum / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006168:Guinea Pigs; D006632:Histamine / Q000633:toxicity; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D010121:Oxytocin / Q000494:pharmacology*; D011708:Pylorus / Q000601:surgery; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; C047046:atosiban; D000431:Ethanol; D010121:Oxytocin; D003543:Cysteamine; D006632:Histamine; D011899:Ranitidine; D019342:Acetic Acid; D014668:Vasotocin; D007213:Indomethacin