[Contrast study on effect of shenkang injection and benazepril on human glomerular mesangial extracellular matrix].
OBJECTIVE
To explore the intensity of inhibition of Shenkang Injection (SKI) and Benazepril on various ingredients of human glomerular mesangial extracellular matrix (ECM).


METHODS
Effect of SKI, a herbal preparation for lowering adverse Qi, despelling turbidness, supplementing Qi and activating circulation, and Benazepril were observed by cultured glomerular mesangial cell technique in vitro.


RESULTS
SKI could inhibit the fibronetin, laminin, and type IV collagen of ECM, and the action was dose-dependent. Benazepril could also inhibit the fibronetin and type IV collagen of ECM but was weaker in intensity.


CONCLUSIONS
The effect of SKI was superior to Benazepril in inhibiting ECM.
Guo
L
L
Nanjing University of TCM, Nanjing (210029).
Liu
Y
Y
Mao
W
W
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005109:Extracellular Matrix / Q000378:metabolism; D005333:Fetus; D005353:Fibronectins / Q000378:metabolism; D005920:Glomerular Mesangium / Q000378:metabolism*; D006801:Humans
D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; D004365:Drugs, Chinese Herbal; D005353:Fibronectins; D003094:Collagen; C044946:benazepril