[Biomonitoring of lymphocytes of workers exposed to nickel compounds and an approach to reduction of genetic effects].
While examining the workers of the fire nickel production contacting preferably with insoluble and weakly soluble compounds of nickel, inhibition of DNA repair and increased level of chromosome changes (micronucleus test) were detected. Decreasing of micronucleus number, which was higher in smokers, and tendency to the stimulation of DNA repair synthesis were revealed after 1-month course of ascorbic acid (1 g/day). A level of changes in chromosome structure in the control group was estimated using the index of sister chromatid exchanges (SCE): variation of initial values was in normal bounds (6-8 SCE per cell), after vitamin course it even slightly decreased. High individual variability of chromosome changes and susceptibility to ascorbic acid was found.
Perminova
I N
IN
Sinel'shchikova
T A
TA
Alekhina
N I
NI
Perminova
E V
EV
Zasukhina
G D
GD
D000395:Air Pollutants, Occupational / Q000032:analysis*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D016022:Case-Control Studies; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000139:chemically induced; D004260:DNA Repair; D004334:Drug Administration Schedule; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology; D015162:Micronucleus Tests; D009532:Nickel / Q000737:chemistry / Q000633:toxicity*; D016273:Occupational Exposure / Q000032:analysis*; D012854:Sister Chromatid Exchange / Q000187:drug effects; D012907:Smoking / Q000009:adverse effects; D013997:Time Factors; D014455:Ukraine / Q000453:epidemiology
D000395:Air Pollutants, Occupational; D009532:Nickel; D001205:Ascorbic Acid
Biomonitoring v limfotsitakh rabochikh, kontaktiruiushchikh s soedineniiami nikelia, i podkhod k snizheniiu geneticheskikh effektov.