title: [The search for anti-ulcer agents at IDR].
abstract: 2-Pyridyl-thioacetamide (2-PTA) was synthesized at IDR in 1968. This molecule showed strong antiulcer/antisecretory effects in animals and man by inhibiting the proton pump. Based on our work Astra developed omeprazole which is the No. 1 drug in the world from 1996. 2-PTA remained a very popular template for drug design for a quarter of century.
authors.affiliation: Gyógyszerkutató Intézet Kft., 1325 Budapest, Pf. 82.
authors.forename: F
authors.initials: F
authors.lastname: Andrási
mesh_terms: D000047:Academies and Institutes; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006814:Hungary; D010437:Peptic Ulcer / Q000188:drug therapy; D012106:Research / Q000639:trends
chemical_list: D000897:Anti-Ulcer Agents
vernacular_title: Gyomorfekély elleni szerek kutatása a GYKI-ben.