Selective hippocampal neuron loss in dementia with Lewy bodies.
Hippocampal volume and neuron number were measured using stereological techniques in pathologically confirmed dementia with Lewy bodies (n = 8), Parkinson's disease only (n = 4), and controls (n = 9). We, and others, have previously shown considerable cell loss in the CA1 and subiculum subregions in Alzheimer's disease. In contrast, these regions were spared in dementia with Lewy bodies where a selective loss of lower presubiculum pyramidal neurons was found. These findings suggest a selective loss of frontally projecting hippocampal neurons in dementia with Lewy bodies versus those projecting to temporal lobe regions in Alzheimer's disease.
Harding
Antony J
AJ
Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia. A.Harding@unsw.edu.au
Lakay
Bronwyn
B
Halliday
Glenda M
GM
D000368:Aged; D001284:Atrophy; D002452:Cell Count; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology*; D008568:Memory; D009474:Neurons / Q000473:pathology*