title: Effect of amylin on mast cell secretion as a possible mechanism increasing gastric mucosa resistance.
abstract: Water-immersion restraint stress increased secretory activity of mast cells and led to the formation of erosive lesions in the gastric mucosa. Intraperitoneal administration of amylin in a dose of 0.5 microg/kg 1 h before stress suppressed degranulation of mast cells and decreased the severity of gastric mucosa damages. In in vitro experiments amylin abolished the activating effects of acetylcholine and bradykinin on mast cell degranulation. Amylin-induced stabilization of activated mast cells probably underlies its protective effects during ulceration.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
authors.forename: B A
authors.initials: BA
authors.lastname: Umarova
authors.forename: E A
authors.initials: EA
authors.lastname: Smirnova
authors.forename: G V
authors.initials: GV
authors.lastname: Luk'yantseva
authors.forename: G N
authors.initials: GN
authors.lastname: Kopylova
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
authors.forename: S V
authors.initials: SV
authors.lastname: German
authors.forename: S E
authors.initials: SE
authors.lastname: Zhuikova
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000682:Amyloid / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D058228:Islet Amyloid Polypeptide; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014456:Ulcer / Q000473:pathology; D014867:Water / Q000378:metabolism
chemical_list: D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D014867:Water; D000109:Acetylcholine; D001920:Bradykinin