The relationship between plasma apolipoprotein A-IV levels and coronary heart disease.
OBJECTIVE
To evaluate the relationship between plasma apoA-IV levels and coronary atherosclerosis and to explore its relation to other risk factors.


METHODS
Using ELISA techniques, plasma apoA-IV levels were quantified in 181 patients who underwent coronary angiography (CAG). Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on CAG, n = 118) and a control group (normal CAG, n = 63). The severity of atherosclerosis was assessed by stenosis scoring of the different lesions. Other parameters, including apoA-I, apoB, Lp(a), HDL-C, LDL-C, TG, and TC, were measured as well. Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA-IV levels.


RESULTS
When compared with the control group, plasma apoA-IV levels were found to be lower in the CHD group. There was a weak negative correlation between plasma apoA-IV levels and the severity of coronary atherosclerosis. ApoA-IV was found to be a relatively independent risk factor for CHD. We also found a positive correlation between apoA-IV and triglyceride levels.


CONCLUSIONS
ApoA-IV may be important in the prediction of CHD and coronary atherosclerosis severity. It may also play an important role in the metabolism of triglycerides.
Manpuya
M W
MW
Third Hospital, Beijing University Medical School, Beijing 100083, China.
Guo
J
J
Zhao
Y
Y
D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D001053:Apolipoproteins / Q000097:blood; D001054:Apolipoproteins A / Q000097:blood*; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000097:blood / Q000473:pathology; D003327:Coronary Disease / Q000097:blood / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D001053:Apolipoproteins; D001054:Apolipoproteins A; D008055:Lipids; D008074:Lipoproteins; C022205:apolipoprotein A-IV