[Effect of total flavonoids of Astragalus on nitroxide in ischemia reperfusion injury].
OBJECTIVE
To study the protective effect of total flavonoids of Astragalus (TFA) on ischemia/reperfusion injury.


METHODS
Change of nitrite (NO2-), the terminal product of nitric oxide (NO) metabolism, and the effect of TFA and chloroquine (a phospholipase A2 inhibitor) on it were observed with hemorrhagic shock/reperfusion injury (S/R) rabbit model.


RESULTS
Plasma NO2- content was positively correlated with blood pH and total carbon dioxide content lowering. TFA and chloroquine could block the decrease of NO in certain degree and might have some effect on maintaining acid-base balance of body.


CONCLUSIONS
TFA has protective effect on ischemia/reperfusion injury.
Wang
D
D
General Hospital of PLA, Beijing, China.
Wang
C
C
Tian
Y
Y
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D011817:Rabbits; D011897:Random Allocation; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000150:complications / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D009569:Nitric Oxide