title: Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population: prospective case-controlled study.
abstract: BACKGROUND
  Gastric cancer is still the most common malignant tumor in Koreans. Although many reports have supported the association of Helicobacter pylori infection and the development of gastric cancer, few studies have been adjusted by variable factors such as age. sex, education, and economic status. Furthermore, most results from areas with a high incidence of gastric cancer, such as China and Korea, have failed to document any relationship between H. pylori infection and gastric cancer. We conducted a prospective case-controlled study, with controls matched for and adjusted by age, sex, education, and economic status, to evaluate the causal relationship between H. pylori infection and gastric cancer in Korean people.
  
  
  METHODS
  From March 1997 to October 1998, 136 consecutive patients with gastric cancer, diagnosed by endoscopic histology, and 136 age- and sex-matched control subjects, confirmed to be free of gastric cancer by endoscopy during the same period, were enrolled in the study. The presence of H. pylori infection was determined by enzyme immunoassay (EIA) serology test.
  
  
  RESULTS
  Seventy-two of the 136 gastric cancer patients (53%) were positive for H. pylori infection and 54 of the 136 control subjects (40%) were positive for H. pylori infection. The odds ratio (OR), adjusted by variable risk factors, such as age, sex, education, and economic status, for gastric cancer in H. pylori-infected patients was 1.82 (95% confidence internal [CI], 1.10-3.00; P = 0.019). The age- and sex-matched OR by conditional logistic regression was 1.6 (95% CI., 1.01-2.53; P = 0.043).
  
  
  CONCLUSIONS
  H. pylori infection may be one of the important risk factors for the development of gastric cancer in Korea, an area of high prevalence of H. pylori infection and a high incidence of gastric cancer.
authors.affiliation: Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
authors.forename: W K
authors.initials: WK
authors.lastname: Chang
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: C K
authors.initials: CK
authors.lastname: Park
authors.forename: J Y
authors.initials: JY
authors.lastname: Yoo
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: M K
authors.initials: MK
authors.lastname: Kim
authors.forename: B Y
authors.initials: BY
authors.lastname: Choi
authors.forename: H S
authors.initials: HS
authors.lastname: Choi
authors.forename: K N
authors.initials: KN
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D012698:Serologic Tests; D012959:Socioeconomic Factors; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology