title: Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine.
abstract: Asymmetrical dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor, which has been suggested to be a novel independent risk factor for endothelial dysfunction and coronary heart disease. We investigated the association of ADMA concentration in serum with risk of acute coronary events. We did a prospective, nested, case-control study in middle-aged men from eastern Finland. In an analysis of men who did not smoke, those who were in the highest quartile for ADMA (>0.62 micromol/L) had a 3.9-fold (95% CI 1.25-12.3, p=0.02) increase in risk of acute coronary events compared with the other quartiles. Our findings suggest that ADMA is a predictor of acute coronary events.
authors.affiliation: Research Institute of Public Health, University of Kuopio, Kuopio, Finland.
authors.forename: V P
authors.initials: VP
authors.lastname: Valkonen
authors.forename: H
authors.initials: H
authors.lastname: Päivä
authors.forename: J T
authors.initials: JT
authors.lastname: Salonen
authors.forename: T A
authors.initials: TA
authors.lastname: Lakka
authors.forename: T
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: J
authors.initials: J
authors.lastname: Laakso
authors.forename: R
authors.initials: R
authors.lastname: Laaksonen
mesh_terms: D001120:Arginine / Q000097:blood*; D003327:Coronary Disease / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment
chemical_list: D001120:Arginine