Antimutagenic activity against trp-P-1 of the edible Thai plant, Oroxylum indicum vent.
A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC50 value of 2.78+/-0.15 microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+/-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2.
Nakahara
K
K
Japan International Research Center for Agricultural Sciences (JIRCAS), Tsukuba, Ibaraki. knakahar@affrc.go.jp
Onishi-Kameyama
M
M
Ono
H
H
Yoshida
M
M
Trakoontivakorn
G
G
D016587:Antimutagenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002243:Carbolines / Q000037:antagonists & inhibitors*; D002851:Chromatography, High Pressure Liquid; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009153:Mutagens; D010936:Plant Extracts; D010945:Plants, Edible / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013785:Thailand
D016587:Antimutagenic Agents; D002243:Carbolines; D044950:Flavanones; D005419:Flavonoids; D009153:Mutagens; D010936:Plant Extracts; C006680:baicalein; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole; C019132:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole