title: [Experimental study on the osteoradionerosis of jaw model of dogs with vascular corrosion casting].
abstract: OBJECTIVE
  To study pathologic alterations of mandibular microvascular system in osteoradionecrosis of jaws (ORNJ) in order to disclose its pathologic mechanism.
  
  
  METHODS
  The right maxillofacial regions of 10 dogs were exposed to cobalt-60 radiation with a total dose of 60-80 Gy and dental extraction were performed at 3, 6 months after radiation. The ORNJ was diagnosed by gross observation, X-ray film and histopathologic examination. Then, the vascular corrosion castings of jaws were implemented and investigated.
  
  
  RESULTS
  At 12 months after radiation, 7 cases of ORNJ occured. It was discovered on the casting specimen that the continuity of inferior alveolar arteries remained intact except one case where the artery was obliterated due to lesion involvement. There were defects of vascular networks in the necrotic area with irregular capillaries proliferating in the periphery of lesions and around the inferior alveolar arteries, where x-ray examination showed new bone formation.
  
  
  CONCLUSIONS
  Based on the experimental evidences, a new concept of pathogenesis of ORNJ is put forward: following the formation of "3-hypo" structures, local trauma-repairing process might induce capillary proliferation which bring about a large amount of mitotic death of endotheliocytes, the microcirculation failure takes place leading to ORNJ eventually.
authors.affiliation: School of Stomatology, Shanghai Second Medical University, Shanghai 200011.
authors.forename: X
authors.initials: X
authors.lastname: Xie
authors.forename: W
authors.initials: W
authors.lastname: Qiu
authors.forename: W
authors.initials: W
authors.lastname: Yuan
mesh_terms: D000818:Animals; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D016319:Corrosion Casting; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D007568:Jaw / Q000098:blood supply* / Q000473:pathology / Q000528:radiation effects; D007571:Jaw Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D010025:Osteoradionecrosis / Q000209:etiology / Q000473:pathology*
chemical_list: D003037:Cobalt Radioisotopes