Virus-inhibitory effect of a yeast RNA-tilorone molecular complex in cell cultures.
The virus-inhibitory activity of a molecular complex (MC) of tilorone and yeast RNA was studied in vitro on three virus-cell systems: vesicular stomatitis virus (VSV) - murine fibroblast L929 cells, Venezuelan equine encephalittis virus (VEEV) - swine embryo kidney (SEK) cells and encephalomyocarditis virus (EMCV) - established piglet testicular (EPT) cells. In all these systems the MC exerted an antiviral effect similar to that of polynucleotide interferon (IFN) inducers such as poly(I)-poly(C), larifan and ridostin. The antiviral effect of the MC was similar when the compound was applied before or after virus adsorption to cells. The MC may be regarded as a perspective antiviral agent of common use.
Karpov
A V
AV
D. Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kiev. karpov_av@hotmail.com
Zholobak
N M
NM
Spivak
N Y
NY
Rybalko
S L
SL
Antonenko
S V
SV
Krivokhatskaya
L D
LD
D002478:Cells, Cultured; D007369:Interferon Inducers / Q000494:pharmacology*; D046911:Macromolecular Substances; D009930:Organic Chemicals; D012330:RNA, Double-Stranded / Q000494:pharmacology; D012331:RNA, Fungal / Q000494:pharmacology*; D013994:Tilorone / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects; D015003:Yeasts / Q000235:genetics
D007369:Interferon Inducers; D046911:Macromolecular Substances; D009930:Organic Chemicals; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; C076741:ridostin; C066530:larifan; D013994:Tilorone