title: Persistent efficacy of doramectin topical solution against induced infestations of Bovicola bovis and Solenopotes capillatus.
abstract: A study was conducted in two locations, Wyoming and Wisconsin, USA, to evaluate the persistent efficacy of doramectin topical solution at a dose rate of 500 microg/kg body weight against artificially induced infestations of Bovicola bovis and Solenopotes capillatus on cattle. At each location, lice-free beef calves were individually housed and randomly allocated to treatment. Both B. bovis and S. capillatus were transferred from untreated donor animals to doramectin-treated cattle at the end of 35, 63, 91 or 126 day post-treatment periods. Cattle treated with a saline pour-on served as the control. Based on the geometric means of lice counts 2 weeks following transfer, the persistent efficacy of a single treatment with doramectin topical solution against induced infestations of B. bovis was 100.0, 100.0, 99.5, and 100.0% at post-treatment days of 35, 63, 91, and 126, respectively. Persistent efficacy against induced infestations of S. capillatus, for the same intervals, were 100.0, 94.9, 86.3, and 74.9%.
authors.affiliation: Renewable Resources, University of Wyoming, Box 3354, Laramie, WY 82071-3354, USA. lloyd@uwyo.edu
authors.forename: J E
authors.initials: JE
authors.lastname: Lloyd
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: M A
authors.initials: MA
authors.lastname: Grubbs
authors.forename: J W
authors.initials: JW
authors.lastname: Waggoner
authors.forename: E E
authors.initials: EE
authors.lastname: Norelius
authors.forename: L L
authors.initials: LL
authors.lastname: Smith
authors.forename: A C
authors.initials: AC
authors.lastname: Brake
authors.forename: T L
authors.initials: TL
authors.lastname: Skogerboe
authors.forename: V K
authors.initials: VK
authors.lastname: Shostrom
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000854:Anoplura / Q000187:drug effects*; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010373:Lice Infestations / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D021261:Parasitic Sensitivity Tests / Q000662:veterinary; D008003:Phthiraptera / Q000187:drug effects* / Q000254:growth & development; D011897:Random Allocation; D012996:Solutions; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D012996:Solutions; D007559:Ivermectin; C084101:doramectin