title: [Effects of endothelin-1 on the collagen synthesis of cultured human dental pulp cells].
abstract: OBJECTIVE
  To study the effects of endothelin-1(ET-1) on the collagen synthesis of cultured human dental pulp cells.
  
  
  METHODS
  Cell cultured, enzyme linked immmun sorbent assay (ELISA), and ABC immunhistochemical staining were used in the study.
  
  
  RESULTS
  ET-1 increased the synthesis of soluble type I collagen in different periods besides the 24 h group, and had no effects on the type III collagen; immunohistochemical staining revealed that ET-1 also increased the synthesis of unsoluble type I collagen.
  
  
  CONCLUSIONS
  ET-1 can stimulate type I collagenic synthesis of human dental pulp cells and might have an effect on pulp self-restoration.
authors.affiliation: School of Stomatology, Shanghai Second Medical University, Shanghai 200011.
authors.forename: Y
authors.initials: Y
authors.lastname: Yan
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
mesh_terms: D001205:Ascorbic Acid / Q000494:pharmacology; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D024042:Collagen Type I / Q000096:biosynthesis; D003782:Dental Pulp / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D019332:Endothelin-1 / Q000494:pharmacology*; D006801:Humans; D013997:Time Factors
chemical_list: D024042:Collagen Type I; D019332:Endothelin-1; D003094:Collagen; D001205:Ascorbic Acid