X-ray diffraction and electron microscopy in the polymorphism study of ondansetron hydrochloride.
Using different techniques, we studied the possible formation of ondansetron polymorphs. Ondansetron is a carbazol antiemetic that acts as a competitive, selective inhibitor of 5-HT3 serotonin receptors. The polymorphs were determined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results suggest that the compounds are not true crystallographic polymorphs, but instead are the product of physical structural changes in the drug, which would be of interest pharmaceutically.
Llácer
J M
JM
Department of Pharmacy and Pharmaceutical Technology, University of Granada, Spain.
Gallardo
V
V
Delgado
R
R
Párraga
J
J
Martin
D
D
Ruiz
M A
MA
D000465:Algorithms; D016880:Anisotropy; D000932:Antiemetics / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D008968:Molecular Conformation; D017294:Ondansetron / Q000737:chemistry*; D012996:Solutions
D000932:Antiemetics; D012996:Solutions; D017294:Ondansetron