Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine.
Asymmetrical dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor, which has been suggested to be a novel independent risk factor for endothelial dysfunction and coronary heart disease. We investigated the association of ADMA concentration in serum with risk of acute coronary events. We did a prospective, nested, case-control study in middle-aged men from eastern Finland. In an analysis of men who did not smoke, those who were in the highest quartile for ADMA (>0.62 micromol/L) had a 3.9-fold (95% CI 1.25-12.3, p=0.02) increase in risk of acute coronary events compared with the other quartiles. Our findings suggest that ADMA is a predictor of acute coronary events.
Valkonen
V P
VP
Research Institute of Public Health, University of Kuopio, Kuopio, Finland.
Päivä
H
H
Salonen
J T
JT
Lakka
T A
TA
Lehtimäki
T
T
Laakso
J
J
Laaksonen
R
R
D001120:Arginine / Q000097:blood*; D003327:Coronary Disease / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment
D001120:Arginine