[Mechanism of developing "deprivation" potentiation of population responses of neurons in the CA1 field in hippocampal slices].
In rat hippocampal slices, synaptic transmission from Schaffer collaterals to CA1 neurons was studied by assessment of the effects of cessation of low-frequency testing stimulation to the population spike amplitude. A positive correlation between the duration of the stimulation interruption period (from 10 to 120 min) and the increment of the population spike amplitude (from 30 to 100% above baseline level). The "deprivational" potentiation (DP) offers a property of summation and is able to persist for long (testing was continued up to one hour). Prior induction of the long-term posttetanic potentiation (LPTP) that for 1-3 hours prevents the development of the late rather than the short-term LPTP phase, in our experiments also suppressed the DP induction after 60-min stimulation interruption interval. The same results were obtained in the presence of polymixin B (20 mcM), which is an inhibitor of protein kinase C (PKC) and PKC-dependent phase of the LPTP. This finding provides support for the earlier assumption about the similarity of the mechanisms responsible for the development of the DP and PKC-dependent LPTP phase related with protein phosphorylation.
Popov
V A
VA
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Markevich
V A
VA
D000200:Action Potentials; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D017774:Long-Term Potentiation; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D004791:Enzyme Inhibitors; D011493:Protein Kinase C
Issledovanie mekhanizma razvitiia "deprivatsionnoĭ" potentsiatsii populiatsionnykh otvetov neĭronov polia CA1 na perezhivaiushchikh srezakh gippokampa.