title: Superhydrophobic modification fails to improve the performance of small diameter expanded polytetrafluoroethylene vascular grafts.
abstract: To determine whether superhydrophobic modification of small diameter expanded polytetrafluoroethylene (ePTFE) vascular grafts improves the performance of these grafts, we assessed neointima formation and platelet deposition in standard and superhydrophobic modified ePTFE grafts. Standard and superhydrophobic vascular grafts were implanted in the carotid arteries of two rabbits and two pigs. Furthermore, standard and superhydrophobic vascular patches were implanted in the carotid arteries of seven pigs. After 4 weeks of implantation all patches were removed and histomorphometric data were analyzed. The early thrombotic effect of superhydrophobic modification was examined by quantifying platelet glycoprotein receptor IIIa deposition onto each type of vascular graft after 15 min of in vitro circulation with human blood. All superhydrophobic and standard ePTFE vascular grafts occluded 15 min to 1 h after implantation in both rabbit and pig carotid arteries. All implanted patches remained patent and were completely covered by endothelium. Superhydrophobic modification of ePTFE vascular grafts did not lead to less neointima formation and resulted in significantly more platelet deposition than did standard ePTFE vascular grafts. Thus, superhydrophobic modification does not improve the performance of small diameter ePTFE vascular grafts.
authors.affiliation: Department of Pathology, University Hospital Groningen, The Netherlands. g.j.toes@path.azg.nl
authors.forename: G J
authors.initials: GJ
authors.lastname: Toes
authors.forename: K W
authors.initials: KW
authors.lastname: van Muiswinkel
authors.forename: W
authors.initials: W
authors.lastname: van Oeveren
authors.forename: A J H
authors.initials: AJ
authors.lastname: Suurmeijer
authors.forename: W
authors.initials: W
authors.lastname: Timens
authors.forename: I
authors.initials: I
authors.lastname: Stokroos
authors.forename: J J A
authors.initials: JJ
authors.lastname: van den Dungen
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis / Q000592:standards*; D002339:Carotid Arteries; D008855:Microscopy, Electron, Scanning; D011138:Polytetrafluoroethylene; D011817:Rabbits; D013552:Swine; D017539:Tunica Intima
chemical_list: D011138:Polytetrafluoroethylene