Palladium-catalyzed monoarylation of nitroalkanes.
A general protocol for the Pd-catalyzed-arylation of nitroalkanes is described. Substituted aryl bromides as well as aryl chlorides can be coupled efficiently with a variety of nitroalkanes under mild conditions to selectively yield the monoarylated products. This method tolerates a number of functional groups including ketones, esters, and olefins. Notably, the arylation of nitroalkanes can be effected chemoselectively over ketone and ester arylation.
Vogl
Erasmus M
EM
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Buchwald
Stephen L
SL
D000473:Alkanes / Q000737:chemistry*; D002384:Catalysis; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009578:Nitrobenzenes / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
D000473:Alkanes; D009574:Nitro Compounds; D009578:Nitrobenzenes; D010165:Palladium