title: Magnetic susceptibility of Dy-DTPA-BMA to reperfused myocardial infarction in an excised dog heart model: evidence of viable myocardium.
abstract: OBJECTIVE
  To assess the effects of Dy-DTPA-BMA (sprodiamide) on ex-vivo MR imaging of reperfused acute myocardial infarction.
  
  
  METHODS
  Eighteen dogs were subjected to 2-hour coronary artery occlusion followed by 24-hour reperfusion. Dysprosium-chelate (Dy-DTPA-BMA) was injected into 16 dogs. Twenty minutes before their sacrifice. Two dogs did not receive the contrast medium and were used as controls. Excised hearts were imaged on T2-weighted spin-echo sequence (T2W SE) and T2*-weighted gradient recalled echo sequence (T2*W GRE), then sectioned and double-perfused for planimetric comparison.
  
  
  RESULTS
  Dy-DTPA-BMA induced myocardial signal loss was detected on T2W SE and on T2*W GRE images. The signal loss was observed at the subendocardial location of the myocardial wall inducing an apparent enlargement of the left ventricle cavity and a thinning appearance of the anterior myocardial wall.
  
  
  CONCLUSIONS
  Myocyte necrosis diminishes the potency of dysprosium to cause MR imaging signal intensity loss in reperfused myocardial infarction. Pre-infarcted myocardium with potentially reversible viability may be responsible for the effect of the contrast medium.
authors.affiliation: Department of Radiology, Fuwai Cardiovascular Hospital, CAMS & PUMC, Beijing 100037, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.forename: D
authors.initials: D
authors.lastname: Revel
authors.forename: C
authors.initials: C
authors.lastname: Arteaga
authors.forename: E
authors.initials: E
authors.lastname: Canet
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: G
authors.initials: G
authors.lastname: Hadour
authors.forename: R
authors.initials: R
authors.lastname: Forrat
authors.forename: A
authors.initials: A
authors.lastname: Oksendal
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D004285:Dogs; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000175:diagnosis*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000473:pathology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004369:Pentetic Acid