[Extracorporeal methods in treating sarcoidosis patients].
The study was undertaken to develop basically new treatments of patients with sarcoidosis, namely: plasmapheresis and extracorporeal lymphocytic modification (ELM) with steroids, infrared laser or cytostatics. The authors analyzed the outcomes of treatment: 50 patients received plasmapheresis, in 52, 20, and 48 had ELM using prednisolone, infrared laser, and cyclosporin, respectively. Plasmapheresis used in the treatment regimen substantially reduced the dosage of corticosteroids. The outcomes of infrared laser therapy were comparable to those of plasmapheresis one. Positive clinical and X-ray changes of a tuberculous process were achieved with prednisolone or cyclosporin ELM in 95% of cases. As this took place, there were certain differences in the time course of X-ray changes. If prednisolone ELM promoted first of all reversal of interstitial changes, cyclosporin ELM affected a granulomatous process to a greater extent and alveolitis to a lesser one. Therapy-induced exacerbations were seen in none case. There were complications in 4% of cases.
Romanov
V V
VV
D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D010789:Phototherapy; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D012507:Sarcoidosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*
D016572:Cyclosporine; D011239:Prednisolone
Ekstrakorporal'nye metody v lechenii bol'nykh sarkoidozom.