Construction and analysis of a human-chimpanzee comparative clone map.
The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.
Fujiyama
Asao
A
RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. afujiyam@gsc.riken.go.jp
Watanabe
Hidemi
H
Toyoda
Atsushi
A
Taylor
Todd D
TD
Itoh
Takehiko
T
Tsai
Shih-Feng
SF
Park
Hong-Seog
HS
Yaspo
Marie-Laure
ML
Lehrach
Hans
H
Chen
Zhu
Z
Fu
Gang
G
Saitou
Naruya
N
Osoegawa
Kazutoyo
K
de Jong
Pieter J
PJ
Suto
Yumiko
Y
Hattori
Masahira
M
Sakaki
Yoshiyuki
Y
D000818:Animals; D001483:Base Sequence; D022202:Chromosomes, Artificial, Bacterial; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D003001:Cloning, Molecular; D020451:Contig Mapping; D005260:Female; D015723:Gene Library; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008297:Male; D002679:Pan troglodytes / Q000235:genetics*; D020161:Physical Chromosome Mapping; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D016324:Sequence Tagged Sites; D014960:X Chromosome / Q000235:genetics; D014998:Y Chromosome / Q000235:genetics