Methanol-induced optic neuropathy: treatment with intravenous high dose steroids.
The aim of this study was to find the potential benefit of intravenous high dose steroids in the treatment of patients with methanol optic neuropathy. Four patients complaining of diminution of vision after taking methylated spirit presented to us within a variable period of its consumption. The systemic features of methanol poisoning were absent in these patients. Raised blood levels of methanol confirmed the diagnosis of methanol optic neuropathy. All these patients received high doses of intravenous steroids for three days, followed by oral steroids, 1 mg/kg body weight, for 11 days. The administration of high doses of intravenous steroids led to an improvement of visual status in all four patients. Intravenous high dose steroids benefit the visual status of patients with methanol-induced optic neuropathy, provided the interval between the consumption of methanol and starting treatment is short. Further studies should be undertaken to document the role of intravenous steroids in this context.
Sodhi
P K
PK
Maulana Azad Medical College, Guru Nanak Eye Centre, New Delhi, India.
Goyal
J L
JL
Mehta
D K
DK
D000328:Adult; D004334:Drug Administration Schedule; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D000432:Methanol / Q000506:poisoning*; D008775:Methylprednisolone / Q000008:administration & dosage*; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D014792:Visual Acuity
D005938:Glucocorticoids; D008775:Methylprednisolone; D000432:Methanol