Safety of the new macrolide immunomodulators.
With the wide acceptance of cyclosporine in the treatment of skin disease, there has been an effort to find new immunomodulating agents with superior safety profiles for use in dermatology. Among the most promising of the classes are the new macrolide immunomodulators, including tacrolimus and pimecrolimus. Of these, only tocrolimus has had widespread use for nondermatologic indications, primarily solid organ transplantation. Both of these agents have been studied for inflammatory diseases of the skin. In this article, we review the systemic and topical toxicities of these macrolide immunomodulators.
Robinson
N
N
Department of Dermatology, Northwestern University, Chicago, IL 60611, USA.
Singri
P
P
Gordon
K B
KB
D006801:Humans; D018942:Macrolides / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D012871:Skin Diseases / Q000188:drug therapy* / Q000276:immunology*; D016559:Tacrolimus / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome
D018942:Macrolides; C117268:pimecrolimus; D016559:Tacrolimus