[Gene therapy of tumors, state of the art and prospects].
Gene therapy entered the clinical arena more than one decade ago. Hundreds of clinical trials were initiated worldwide to investigate many different approaches to oncological problems. Positive results became available only recently, showing that gene therapy is actually capable of curing human neoplasms. This editorial scrutinizes the whole field of gene therapy for cancer, describing advantages and disadvantages of the various approaches, and trying to forecast the main future developments.
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D000256:Adenoviridae / Q000235:genetics; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D024201:Bystander Effect; D002986:Clinical Trials as Topic; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D005544:Forecasting; D015774:Ganciclovir / Q000494:pharmacology / Q000627:therapeutic use; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000627:therapeutic use; D020544:Graft vs Leukemia Effect; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors / Q000235:genetics; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000235:genetics
D020533:Angiogenesis Inhibitors; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D014764:Viral Proteins; D013937:Thymidine Kinase; D015774:Ganciclovir
Terapia genica dei tumori, stato dell'arte e prospettive.