[Apoptosis inducing effect of meisoindigo on K562 cells].
OBJECTIVE
To study the effect of meisoindigo on human chronic myelogenous leukemia (CML) cell line K562 cells for exploring the mechanism of meisoindigo in treatment of CML.


METHODS
Multiple methods, including dose-response curve, trypan blue exclusion, cytomorphology, DNA electrophoresis, flow cytometry and TUNEL (TdT mediated dUTP nick and labeling), were used to observe the effect of meisoindigo on K562 cells.


RESULTS
Meisoindigo can inhibit the proliferation and induce the apoptosis of K562 cells.


CONCLUSIONS
The therapeutic mechanism of meisoindigo in treating CML may be related with its proliferation inhibiting and apoptosis inducing effect in CML cells.
Song
L
L
Institute of Hematology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin (300020).
Qian
L
L
D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D020014:K562 Cells / Q000473:pathology*
D007211:Indoles; C047330:N-methylisoindigotin