[Effect of dingxin recipe on arrhythmia and injury induced by ischemia and reperfusion in rabbits].
OBJECTIVE
To investigate the protective effect of Dingxin Recipe (DXR) on arrhythmia and injury induced by ischemia and reperfusion.


METHODS
Rabbits were randomly divided into four groups and administered orally with DXR of high dose, low dose, propanolol and distilled water. Two-step coronary artery ligature was used to form ischemia and reperfusion model. Superoxide dismutase (SOD), cyclic adenosine monophosphate (cAMP), norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), myocyte ultrastructural injury and occurrence of arrhythmia were investigated.


RESULTS
DXR could obviously antagonize arrhythmia induced by myocardial infarction or ischemia and reperfusion in rabbits. Compared with the control group, DXR of high and low doses could improve the changes in ST-T. In rabbits treated with DXR, the levels of SOD were elevated while cAMP, NE, DA, 5-HT and the whole blood viscosity were lowered.


CONCLUSIONS
DXR could obviously antagonize arrhythmia and injury induced by ischemia and reperfusion, DXR may clear oxygen free radical, regulate the second messenger, inhibit sympathetic nerve system, improve local circulation, protect mitochondria and prevent the activation of lysosome and safeguard the cardiac myocyte to be free from injury.
Jia
Y
Y
First Military Medical University, Guangzhou (510515).
Yu
L
L
Chen
Y
Y
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D008929:Mitochondria, Heart / Q000648:ultrastructure; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000648:ultrastructure; D011817:Rabbits; D011897:Random Allocation
D000889:Anti-Arrhythmia Agents; D004365:Drugs, Chinese Herbal; C574801:dingxin