Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats.
Linkage analysis previously demonstrated a blood pressure quantitative trait locus (QTL) on rat Chromosome 2 (Chr 2) in crosses utilizing Dahl salt-sensitive (S) rats. The present work dissects this QTL by using congenic strains in which segments of Chr 2 from Wistar Kyoto rats (WKY) are placed on the S genetic background. Two distinct QTLs were found where one QTL was anticipated. These each accounted for a blood pressure of 15-20 mm Hg in rats fed 2% NaCl diet for 24 days. One QTL was in the <9-cM interval between D2Rat35 and D2Wox18 (Fgg), and the other was in the <7-cM interval between D2Wox18 (Fgg) and D2Mgh10. A third tentative QTL was suggested, but not clearly established, in the <3-cM interval between D2Mgh10 and D2Rat259.
Garrett
Michael R
MR
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614-5805, USA.
Rapp
John P
JP
D000818:Animals; D001794:Blood Pressure / Q000235:genetics*; D002874:Chromosome Mapping; D019655:Quantitative Trait, Heritable; D051381:Rats; D020303:Rats, Inbred Dahl / Q000235:genetics*; D011921:Rats, Inbred WKY / Q000235:genetics*; D013045:Species Specificity