[Systemic markers of inflammation after coronary angioplasty].
THE RISK OF RESTENOSIS: Coronary angioplasty is an effective treatment of stable and instable coronary disease and its principle limitation, despite technical progress, remains restenosis. In instable angina, the physiopathologic and prognostic role of inflammation proteins is well documented. THE ROLE OF THE C-REACTIVE PROTEIN (CRP): Is a validated risk factor for patients presenting with heart failure, whether instable or stable angina and in the general population. This risk factor is distinct from tobacco abuse, hypercholesterolemia or diabetes. In all the series studied to date, the frequency of restenosis following coronary angioplasty increases when CRP values are high prior to surgery and continue to rise up to the 48th or 72nd hour.


CONCLUSIONS
New therapeutic measures widen the possibilities of mechanical strategies (angioplasty with or without stent) and treatment of inflammatory mechanisms in the atheromatous plaques (statines, brachytherapy or "covered" stents).
Donal
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Département de Cardiologie, CHU La Milétrie, Poitiers. d.coisne@chu-poitiers.fr
Allal
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J
Christiaens
L
L
Lecron
J C
JC
Ragot
S
S
Coisne
D
D
D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D023903:Coronary Restenosis / Q000097:blood* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood*; D011379:Prognosis
D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein
Marqueurs systémiques de l'inflammation après angioplastie coronaire.