title: The relationship between sleep and epilepsy.
abstract: Seizures occur extensively during sleep or on awakening in a substantial proportion of patients with epilepsy. Interictal epileptiform discharges are also influenced by sleep and sleep deprivation. Continuous spike-waves in slow-wave sleep are the hallmark of Landau-Kleffner syndrome and ESES (Electrical Status in Slow Sleep). Sleep deprivation is known to influence not only the occurrence but also the symptomatology of epileptic seizures. Sleep architecture and daytime alertness are influenced by seizures and antiepileptic medications. This review examines the clinical and basic science aspects of this relationship between sleep and epilepsy.
authors.affiliation: Section of Pediatric Epilepsy and Sleep Disorders, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: P
authors.initials: P
authors.lastname: Kotagal
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002940:Circadian Rhythm; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000503:physiopathology; D012640:Seizures / Q000503:physiopathology; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants