[The association between A1166-->C of angiotensin II type 1 receptor gene and pregnancy induced hypertension].
OBJECTIVE
To determine the distribution of gene type of A1166 polymorphism site of the angiotensin II type 1 receptor gene (AT1RG) and whether it might be implicated in pregnancy induced hypertension (PIH) woman.


METHODS
We used polymerase chain reaction (PCR), restriction enzyme analysis and electrophoresis for this study.


RESULTS
1. The gene types of A1166 polymorphism site of AT1R gene on normal control and PIH and essential hypertension subjects were in accordance with Hardy-Weinberg laws. 2. The C allele frequencies of AT1R gene (A1166-->C) in control, PIH, and essential hypertension subjects was 3.7%, 11.4%, and 9.4%, respectively. 3. The frequency of variants(AC, CC) of AT1R gene A1166 polymorphism site in PIH (20.5%) was significantly higher than that of control subjects (7.4%). 4. The gene type of variants (AC, CC) and C allele frequency of AT1R gene A1166 polymorphism site in essential hypertension (18.8%, 9.4%, respectively) was higher than those of control subjects. There is no statistical difference in A1166-->C variants between PIH and essential hypertension.


CONCLUSIONS
1. The variants(A-->C) of 1166 polymorphism site of AT1RG predisposes increased risk of PIH. 2. The PIH patients are at the risk of suffering from essential hypertension.
Hu
Y
Y
Department of Obstetrics and Gynecology, First Affiliated Hospital, Medical College of Jiamusi University, Jiamusi 154003, China.
Bi
Y
Y
Guan
G
G
D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology*; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000235:genetics*
D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin