[Clinical study of fibrinolysis indicators in patients with chronic pulmonary heart disease].
OBJECTIVE
To investigate the change of D-dimer and other fibrinolysis indicators in patients with chronic pulmonary heart disease.


METHODS
The fibrinolytic activity of plasma was measured in 42 patients with chronic pulmonary heart disease and in 20 controls (matched with sex and age).


RESULTS
The D-dimer level was significantly higher in exacerbated patients than in controls (P < 0.001). The fibrinolytic activity in patients was lower than in controls. The plasma fibrinolytic activity was positively correlated with PaO2 and negativly correlated with PaCO2.


CONCLUSIONS
The depressed fibrinolysis may be associated with hypercoagulability state of chronic pulmonary heart disease and contributes to thrombi in small pulmonary arteries and arterioles. D-dimer can be used in diagnosis of thrombi formation in small pulmonary arteries and arterioles. Patients with chronic pulmonary heart disease can be treated with fibrinolysis drugs.
Guo
L
L
Department of Respiratory Disease, Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000.
Wang
B
B
Xiao
L
L
D000368:Aged; D002908:Chronic Disease; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D011660:Pulmonary Heart Disease / Q000378:metabolism* / Q000503:physiopathology
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D