[Serum concentration of prolactin, gastrin and glycocholic acid in patient with peptic ulcer treated with ranitidine].
In 66 patients with peptic ulcer (11 with gastric ulcer, 55 with duodenal ulcer, 19 women, 47 men) the serum concentrations of prolactin, dehydrocholic acid and gastrin were determined. The studies were repeated after treatment with ranitidine: in 50 patients after three weeks and in 40 patients after another 30 days. During the first period ranitidine 2 x 150 mg was administered, while during the second period the dose was 1 x 150 mg. The results were compared with those obtained from 120 healthy subjects. Before starting the treatment prolactin levels were significantly higher than those in the control group. During the treatment a significant decrease of the levels was observed. Similar changes of prolactin concentrations were found in the group of 39 men with duodenal ulcer isolated from the studied patients, who were compared with a group of 50 healthy men. It was not found that the development of peptic ulcer and the treatment with ranitidine exerted and effect on the changes of gastrin and dehydrocholic acid concentrations.
Przybyłowski
J
J
Klinika Chorób Wewnetrznych Instytut Medycyny Klinicznej w Kielcach, AM w Krakowie.
Kowalski
D
D
Widłak
H
H
Kowalska
K
K
Maślany
P
P
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D005755:Gastrins / Q000097:blood*; D006000:Glycocholic Acid / Q000097:blood*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000097:blood* / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood*; D011899:Ranitidine / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
D000897:Anti-Ulcer Agents; D005755:Gastrins; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D011388:Prolactin; D006000:Glycocholic Acid
Stezenie prolaktyny, gastryny i kwasu glikocholowego w surowicy chorych na wrzód trawienny leczonych ranitydyna.