[Specific binding of GABA in the adrenal glands and catecholamine blood and adrenal gland levels in rats under stress with inhibited functioning of the hypothalamus-hypophyseal-adrenocortical systems].
Forced swimming of intact rats was accompanied by an activation of the hormonal link in sympatho-adrenal system and by a decrease in the level of specific binding of 14C-GABA by adrenal plasma membranes; the former was prevented with the administration of GABAergic preparations (baclofen, GABA-taurine) before stress. Under inhibition of the function of hypothalamo-pituitary-adrenocortical axis following multiple hydrocortisone administration and, in presence of developing metabolic disorders and adrenal secretion of catecholamines, the latter reacted to stress by a decrease in adrenalin, noradrenaline and dopamine secretion without changing the intensity of specific binding of GABA. Administration of GABAergic preparations before stress prevented the development of stress disorders of noradrenaline and dopamine secretion partially or completely, and sodium thiosulphate administration increased acutely specific binding of GABA with adrenal plasma membranes simultaneously preventing the accumulation of adrenal noradrenaline and the decrease in blood DOPA level.
Myshunina
T M
TM
V.P. Komisarenko Institute of Endocrinology and Metabolism of AMS, Kiev.
Kalinichenko
O V
OV
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D002395:Catecholamines / Q000097:blood* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology*; D013550:Swimming; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002395:Catecholamines; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Spetsyfichne zv'iazuvannia GABA u nadnyrkovykh zalozakh i vmist katekholaminiv u krovi ta nadnyrkovykh zalozakh pry stresuvanni shchuriv za umov hal'muvannia hipotalamo-hipofizarno-adrenokortykal'noï systemy.