[Efficacy of somatostatin analogs in the treatment of neuroendocrine tumours and paraneoplastic syndromes].
BACKGROUND
The authors report their experience with octreotide LAR in the adjuvant treatment of 10 patients suffering from neuroendocrine tumours and paraneoplastic syndromes.


METHODS
All patients were studied preoperatively using traditional radiology and scintigraphy using octreoscan.


RESULTS
Octreoscan was positive in all cases for somatostatin receptors. All patients with neuroendocrine tumours underwent surgery of the primary neoplasm; treatment with somatostatin was commenced at a later stage.


CONCLUSIONS
The authors' experience with octreotide LAR proved to be an efficacious means of controlling symptoms and stabilising disease without collateral effects. They conclude by affirming that octreotide LAR represents a valid therapeutic choice in the symptomatic treatment of neuroendocrine tumours.
Sperlongano
P
P
Istituto di Chirurgia Sperimentale, V Divisione di Chirurgia Generale e Tecniche Speciali Chirurgiche, Seconda Università degli Studi, Naples, Italy.
De Falco
M
M
Pisaniello
D
D
Parmeggiani
D
D
Parmeggiani
U
U
D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D015282:Octreotide / Q000627:therapeutic use*; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D018931:Antineoplastic Agents, Hormonal; D013004:Somatostatin; D015282:Octreotide
Efficacia degli analoghi della somatostatina nel trattamento dei tumori neuroendocrini e delle sindromi paraneoplastiche.