Chromium vinylidene carbenoids: stereospecific synthesis of (Z)-2-chloroalk-2-en-1-ols.
(Z)-2-Chloroalk-2-en-1-ols are obtained in excellent yields from a wide variety of aldehydes by addition of (E)-chromium vinylidene carbenoids, stereospecifically generated from trichloroalkanes using CrCl(2) in THF at room temperature. [reaction: see text]
Barma
D K
DK
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.
Baati
R
R
Valleix
A
A
Mioskowski
C
C
Falck
J R
JR
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002857:Chromium / Q000737:chemistry*; D006838:Hydrocarbons; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry*
D000438:Alcohols; D006838:Hydrocarbons; D014753:Vinyl Compounds; D002857:Chromium; C030011:carbene; D008697:Methane