Presence of BRCA1 and BRCA2 proteins in human milk fat globules after delivery.
We evaluated BRCA1 and BRCA2 oncosuppressor protein expression in 26 milk samples in women just after delivery. The quantification of BRCA1 and BRCA2 proteins was performed in isolated milk fat globules using an affinity chromatography strategy. The amounts of BRCA1 and BRCA2 proteins were found to be similar. We explained the presence of BRCA1 and BRCA2 proteins in human milk fat globules by the fact that they are formed by exocytosis of lipids from epithelial cells of the mammary gland and are enveloped by plasma membrane from the apical part of the milk-secreting cells. This raises the possibility that BRCA1 and BRCA2 proteins are a protective response to proliferation and play a possible role in newborn nutrition.
Vissac
Cécile
C
Laboratoire d'Oncologie Moléculaire, Centre Jean Perrin, 63011 Clermont-Ferrand, France.
Lémery
Didier
D
Le Corre
Ludovic
L
Fustier
Pierre
P
Déchelotte
Pierre
P
Maurizis
Jean Claude
JC
Bignon
Yves Jean
YJ
Bernard-Gallon
Dominique J
DJ
D019313:BRCA1 Protein / Q000032:analysis* / Q000276:immunology; D024682:BRCA2 Protein / Q000032:analysis* / Q000276:immunology; D002846:Chromatography, Affinity; D036861:Delivery, Obstetric; D005260:Female; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification; D006023:Glycoproteins / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D066292:Lipid Droplets; D008895:Milk, Human / Q000737:chemistry*; D009747:Nutritional Physiological Phenomena; D013997:Time Factors
D019313:BRCA1 Protein; D024682:BRCA2 Protein; D006017:Glycolipids; D006023:Glycoproteins; C110367:milk fat globule