Histochemical and ultrastructural study of the effect of natrium fluoride on glycogen content in rat hepatocytes.
The aim of the study was to evaluate the effect of natrium fluoride (NaF) on glycogen content in hepatocytes of the offspring rats receiving fluoridated water, basing on histochemical (PAS reaction) and ultrastructural examinations. The experiment used 90 rats obtained from 30 mothers. The animals were given fluoridated water in two different concentrations: 10.6 mg NaF/l and 32.0 mg NaF/l. Material for analysis consisted of liver specimens collected on day 4, 14, 30, 60, 90 and 120 of rats' life. The rats were exposed to fluoride from the intrauterine life, during lactation, till full maturity. The experiment revealed the effect of super-optimal concentrations of natrium fluoride on carbohydrate metabolism of the rat.
Dabrowska
E
E
Department of Conservative Dentistry, Medical Academy of Białystok, Białystok, Poland.
D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008112:Liver Glycogen / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D008854:Microscopy, Electron; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000633:toxicity*
D008112:Liver Glycogen; D012969:Sodium Fluoride