[Immune correction by polyoxidonium in chronic alcoholics with renal impairement].
OBJECTIVE
To study clinical effectiveness and immunocorrective properties of polyoxidonium in chronic alcoholics with renal impairment.


METHODS
The trial enrolled 62 chronic alcoholics with chronic pyelonephritis (CP). Group 1 comprised 28 patients (mean age 39.9 +/- 2.4 years) with severe chronic alcoholism (CA) in long abstinence and grave CP; 16 moderate CA patients of group 2 (mean age 42.2 +/- 1.2 years) with moderate CP in drinking period; the control group consisted of 11 severe CA patients (mean age 39.2 +/- 1.2 years) in short-term abstinence and moderate CP. CP was the only visceral damage in the examinees. All the patients were examined clinically. Biochemical blood tests, ultrasound, x-ray examinations, radionuclide investigation of the kidneys, immunological examination were made before and after the treatment. Patients of groups 1 and 2 received polyoxidonium (12 mg once a day, i.m., each other day, a course dose 0.084 g) in combination with penicillin and nistatin. Patients of group 3 received placebo in combination with the same antibacterial therapy.


RESULTS
Remission with normalization of laboratory and immunological parameters was achieved in 75% of group 1 patients. No response was seen in 7.1%. In group 2 remissions were absent while immunological changes were insignificant. Group 3 patients exhibited clinical response in 48.2% but no remission was achieved.


CONCLUSIONS
Polyoxidonium immunocorrection was effective in CA patients with renal affection only in long-term abstinence being a failure in drinking period.
Tarasova
N S
NS
Beloborodova
E I
EI
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000276:immunology*; D002908:Chronic Disease; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011704:Pyelonephritis / Q000150:complications / Q000276:immunology*
D000276:Adjuvants, Immunologic
Otsenka immunokorrigiruiushchikh svoĭstv polioksidoniia u bol'nykh khronicheskim alkogolizmom s porazheniem pochek.