Novel degradable polymers combining D-gluconic acid, a sugar of vegetal origin, with lactic and glycolic acids.
To synthesize functionalized poly(lactic acid-co-glycolic acid)-based polyesters for biomedical and pharmaceutical applications such as controlled drug delivery, D-gluconic acid was considered as an interesting source of comonomer. Accordingly D-gluconic acid was used to synthesize novel 1,4-dioxane-2,5-diones with protected hydroxyl groups, namely 3-(1,2:3,4-tetraoxobutyl-di-O-isopropylidene)-dioxane-2,5-dione (5a) and 3-methyl-6-(1,2:3,4-tetraoxobutyl-di-O-isopropylidene)-dioxane-2,5-dione (5b). The ring-opening homopolymerization and copolymerization of these cyclic dilactones with DL-lactide provided novel degradable polyesters with higher glass transition temperatures than poly(lactic acid-co-glycolic acid) polymers.
Marcincinova-Benabdillah
K
K
CRBA-UMR CNRS 5473, Faculty of Pharmacy, Montpellier I University, 15 av. Ch. Flahault, 34060 Montpellier, France.
Boustta
M
M
Coudane
J
J
Vert
M
M
D001672:Biocompatible Materials / Q000138:chemical synthesis; D001673:Biodegradation, Environmental; D005942:Gluconates / Q000737:chemistry*; D006016:Glycolates / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis*
D001672:Biocompatible Materials; D005942:Gluconates; D006016:Glycolates; D011108:Polymers; D019344:Lactic Acid; C030691:gluconic acid