title: Synthesis and antiviral assays of some benzimidazole nucleosides and acyclonucleosides.
abstract: Some benzimidazole nucleosides and acyclonucleosides were synthesized and tested in vitro as antiviral agents. None of them showed significant activity. Replacement of the benzenesulphonyl group at N-1 with the ribofuranosyl moiety or with the acyclovir side-chain was deleterious.
authors.affiliation: Department of Pharmaceutical Science, University of Bologna, Italy. lauga@alma.unibo.it
authors.forename: L
authors.initials: L
authors.lastname: Garuti
authors.forename: M
authors.initials: M
authors.lastname: Roberti
authors.forename: G
authors.initials: G
authors.lastname: Gentilomi
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D029822:Enterovirus B, Human / Q000187:drug effects*; D006367:HeLa Cells; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D017955:Poliovirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides