Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site.
Schrag
M L
ML
Drug Metabolism Research, Pharmacia Corporation, Kalamazoo, MI 49007, USA.
Wienkers
L C
LC
D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism; D006418:Heme / Q000378:metabolism*; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014229:Triazolam / Q000378:metabolism*
D017382:Reactive Oxygen Species; D014229:Triazolam; D006418:Heme; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human