title: [Perioperative local instillation of ropivacaine for postoperative pain relief after surgery on extremities].
abstract: BACKGROUND
  The relief of postoperative pain remains one of the most important goals for adequate surgical patient care.
  
  
  METHODS
  Prospective, randomised, double-blinded study, including 118 patients (67 M;/ 51 F; median age 43 years, min. 18, max. 74). Two groups were formed. In the verum group a wound instillation with ropivacaine was performed, in the control group not. Intensity of pain, demand for analgesics and satisfaction of the patient were evaluated postoperatively. In 10 patients ropivacaine plasma levels were measured.
  
  
  RESULTS
  Significant postoperative pain relief and a decrease in analgesic consumption were found on instillation of ropivacaine. Compared to the control group, patients receiving ropivacaine were significantly more satisfied with the postoperative pain management. Potential toxic plasma levels were not found.
  
  
  CONCLUSIONS
  By the presented method, the surgeon actively contributes to a significant reduction in postoperative pain and analgesic consumption. Furthermore, the patient's benefit is reflected by higher satisfaction with the pain management. Complications due to toxic plasma levels are not seen.
authors.affiliation: Klinik für Unfall- und Wiederherstellungschirurgie, Universität Leipzig. Jan.Korner@ao-asif.ch
authors.forename: J
authors.initials: J
authors.lastname: Korner
authors.forename: H
authors.initials: H
authors.lastname: Lill
authors.forename: P
authors.initials: P
authors.lastname: Hepp
authors.forename: B
authors.initials: B
authors.lastname: Hansel
authors.forename: H
authors.initials: H
authors.lastname: Fischer
authors.forename: C
authors.initials: C
authors.lastname: Josten
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000577:Amides / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D020878:Device Removal; D004311:Double-Blind Method; D005121:Extremities / Q000293:injuries* / Q000601:surgery; D005260:Female; D005593:Fracture Fixation, Internal; D050723:Fractures, Bone / Q000601:surgery*; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D017060:Patient Satisfaction; D011446:Prospective Studies; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000077212:Ropivacaine
vernacular_title: Perioperative lokale Instillation von Ropivacain zur postoperativen Schmerzreduktion in der Extremitätenchirurgie. Eine prospektiv randomisierte Doppelblindstudie.