Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's disease.
We have previously reported a significant association between early-onset Alzheimer's disease (EOAD) and an allele in the promoter of presenilin 1 (PSEN1) significantly decreasing PSEN1 expression in vitro. For late-onset Alzheimer's disease (LOAD), numerous studies have reported inconsistent associations with a PSEN1 intronic polymorphism. We therefore hypothesized that linkage disequilibrium between the intronic PSEN1 polymorphism and the functional promoter polymorphism might explain the conflicting reports in LOAD. We analysed both variations in 356 LOAD patients and 230 controls in a population-based case-control study. In addition, we re-analysed all published literature on the PSEN1 intronic polymorphism in a meta-analysis. No significant association was found with the PSEN1 intronic or promoter polymorphism in our case-control sample. In the meta-analysis no major differences between patients and controls were found for the PSEN1 intronic variation. Together, our results do not support a major role for variable expression of PSEN1 in LOAD.
Dermaut
B
B
University of Antwerp, Department of Biochemistry. Universiteitsplein 1, Antwerpen, Belgium.
Roks
G
G
Theuns
J
J
Rademakers
R
R
Houwing-Duistermaat
J J
JJ
Serneels
S
S
Hofman
A
A
Breteler
M M
MM
Cruts
M
M
Van Broeckhoven
C
C
van Duijn
C M
CM
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000032:analysis / Q000096:biosynthesis*; D011110:Polymorphism, Genetic; D053764:Presenilin-1; D012307:Risk Factors
D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1