Model organisms as a guide to mammalian aging.
Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast Saccharomyces cerevisiae and highlight general features of the regulation of aging that may have implications for mammals.
Tissenbaum
Heidi A
HA
Program in Gene Function and Expression, University of Massachusetts Medical School, New Research Building Suite 604, 364 Plantation Street, Worcester, MA 01605, USA. heidi.tissenbaum@umassmed.edu
Guarente
Leonard
L
D000375:Aging / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D008322:Mammals; D023421:Models, Animal; D012441:Saccharomyces cerevisiae / Q000502:physiology*