[Ability of novel non-competitive glutamate receptor blocking agents to weaken motor disorders in animals].
Action of mono- and dication derivatives of phenylcyclohexyl was compared with effects of known NMDA-antagonists memantine and dizocilpine. Seizures induced with the NMDA were effectively prevented both by mono- and dications, whereas against the kainate seizures dication alone was effective. Anticataleptic activity was much stronger in monocations, and the side effect of the substances under study on motor co-ordination was obviously weaker than in dizocilpine. Thereupon, the phenylcyclohexyl derivatives might be regarded as potential means for treatment of parkinsonism and other motor disorders.
Rukoiatkina
N I
NI
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg, 194223, pr. M. Torez, 44, Russia.
Gorbunova
L V
LV
Gmiro
V E
VE
Lukomskaia
N Ia
NIa
D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001259:Ataxia / Q000139:chemically induced; D001555:Benzene Derivatives / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002375:Catalepsy / Q000188:drug therapy; D002412:Cations; D003510:Cyclohexanes / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006220:Haloperidol; D007608:Kainic Acid; D051379:Mice; D016202:N-Methylaspartate; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D001555:Benzene Derivatives; D002412:Cations; D003510:Cyclohexanes; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D016202:N-Methylaspartate; D006220:Haloperidol; D007608:Kainic Acid
Sposobnost' novykh nekonkurentnykh blokatorov glutamatnykh retseptorov oslabliat' dvigatel'nye narusheniia u zhivotnykh.