Warning of high-flux hemodialysis.
In order to estimate the influence of flux on plasma refilling during hemodialysis (HD), prospective crossover studies were performed in 10 HD patients with low-flux and high-flux dialyzers. Hematocrit was continuously monitored to assess changes in blood volume. In addition, plasma osmolarity and total protein concentration were measured. Intradialytic reductions in body weight (-5 +/- 1 vs -5 +/- 1%) and plasma osmolarity (-5 +/- 1 vs -5 +/- 1%) were similar in both conditions. Although mean blood pressure remained unchanged in either state, the decrease in blood volume was larger in high-flux HD (-13 +/- 2 vs -10 +/- 2%, p<0.05). In spite of greater contraction in blood volume during high-flux HD, total proteins were increased equally between low-flux and high-flux HD (11 +/- 4 vs 11 +/- 4%). Our data that although high-flux HD failed to induce significant drops in blood pressure, it elicited greater magnitude of decreases in blood volume, implicate the judicious application of high-flux HD.
Takenaka
T
T
Shinjuku Suimei Clinic, Tokyo, Japan.
Kobayashi
K
K
Suzuki
H
H
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D001798:Blood Proteins / Q000378:metabolism; D001810:Blood Volume; D000075202:Contraindications; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007019:Hypoproteinemia; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods*
D001798:Blood Proteins