[The combined therapy of carboplatin, fluorouracil and radiotherapy for moderate and advanced non-small cell lung cancer].
OBJECTIVE
To observe the effect of combined chemotherapy (carboplatin and fluorouracil) with radiotherapy for moderate and advanced non-small cell lung cancer.


METHODS
Eighty patients with moderate and advanced non-small cell lung cancer were randomized into 2 groups, radiotherapy group(R) and carboplatin, fluorouracil plus radiotherapy group (CF + R). All patients in two groups received conventional radiotherapy. Patients in CF + R group received combined chemotherapy with carboplatin(100 mg, d 1-5) 5-fluorouracil(500 mg d 1-5) in the first and fourth weeks during radiotherapy.


RESULTS
The complete response rate was 48% in CF + R group, 25% in R group. The 1-year, 3-year, 5-year survival rates were 63%, 38%, 18% in CF + R group, and 40%, 15%, 8% in R group. The major toxic reactions in CF + R group were grade I-II myelo-suppression and digestive tract reaction.


CONCLUSIONS
Combined chemotherapy(carboplatin and fluorouracil) with radiotherapy is preferable for non-small cell lung cancer.
Qiao
T
T
Taishan Medical College Hospital, Taian 271000.
Xin
L
L
Liu
H
H
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D016190:Carboplatin; D005472:Fluorouracil