[The search for anti-ulcer agents at IDR].
2-Pyridyl-thioacetamide (2-PTA) was synthesized at IDR in 1968. This molecule showed strong antiulcer/antisecretory effects in animals and man by inhibiting the proton pump. Based on our work Astra developed omeprazole which is the No. 1 drug in the world from 1996. 2-PTA remained a very popular template for drug design for a quarter of century.
Andrási
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Gyógyszerkutató Intézet Kft., 1325 Budapest, Pf. 82.
D000047:Academies and Institutes; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006814:Hungary; D010437:Peptic Ulcer / Q000188:drug therapy; D012106:Research / Q000639:trends
D000897:Anti-Ulcer Agents
Gyomorfekély elleni szerek kutatása a GYKI-ben.