title: The lectin-binding properties of six generations of mannose-functionalized dendrimers.
abstract: [structure: see text] First- through sixth-generation PAMAM dendrimers have been functionalized with mannose residues. Characterization with MALDI-TOF MS and (1)H NMR is reported. Different binding enhancements consistent with monovalent interaction, glycoside clustering, and multivalent binding are observed for different generations of dendrimers.
authors.affiliation: Department of Chemistry and Biochemistry, 108 Gaines Hall, Montana State University, Bozeman, Montana 59717, USA.
authors.forename: Eric K
authors.initials: EK
authors.lastname: Woller
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Cloninger
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000737:chemistry*; D050091:Dendrimers; D006386:Hemagglutination Tests; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008358:Mannose / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D011108:Polymers; D011817:Rabbits; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D011108:Polymers; D003208:Concanavalin A; D008358:Mannose