[New therapeutic strategies in gastroenteropancreatic neuroendocrine tumours].
Neuroendocrine tumours are frequently malignant and have often reached an advanced stage by the time of diagnosis when they are inoperable, accompanied by severe symptoms, sometimes of an endocrine nature. Current therapeutic procedures include surgery, embolisation of hepatic metastases, local radiotherapy, biotherapy and chemotherapy. Over the years somatostatin analogs, of which octreotide is the first form, have become increasingly important in the treatment of patients with neuroendocrine tumours. A major step forward in analog treatment is represented by the development of slow-release formulas which do not require multiple daily injections and reduce the onset of resistance. The treatment of neuroendocrine tumours in the future will be based on the increased use of somatostatin analogs alone or in association with interferon or chemotherapy, and will also include surgery, radiometabolic therapy and targeted irradiation of the tumour.
Colao
A
A
Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università Federico II, Naples, Italy. colao@unina.it
Pulcrano
M
M
Dorato
M
M
Müller
F
F
Rossi
F W
FW
De Martino
M C
MC
Biondi
B
B
Lombardi
G
G
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005770:Gastrointestinal Neoplasms / Q000628:therapy*; D006801:Humans; D018358:Neuroendocrine Tumors / Q000628:therapy*; D015282:Octreotide / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000628:therapy*; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors
D018931:Antineoplastic Agents, Hormonal; D017481:Receptors, Somatostatin; D015282:Octreotide
Nuovo strategie terapeutiche nei tumori neuroendocrini gastroenteropancreatici.