[Study on relationship between endometrium laminin expression and irregular uterine bleeding in Norplant users].
OBJECTIVE
To investigate the relationship between endometrium laminin (LN) expression and irregular uterine bleeding in Norplant users.


METHODS
Eighteen endomerium samples obtained during day 10-14th from Norlant users for 1/2, 1 or > 2 years respectively with irregular bleeding were studied morphologically and immunohistochemically for LN expression. Six normal proliferative endometria and 18 connterpacts with regular bleeding were used as control.


RESULTS
In Norplant users, endometrial glands decreased in numbers and asynchromized in appearance. The LN expression on basal lamina of glandular epithelium and vascular endothelium was lower in those with irregular bleeding as compared with regular bleeders (P < 0.05).


CONCLUSIONS
The decline of LN expression may related to irregular bleeding in Norplant users.
Shi
X
X
Department of Reproductive Medicine, Capital University of Medical Sciences, Beijing 100054, China.
Han
X
X
Weng
J
J
D000328:Adult; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D004717:Endometrium / Q000737:chemistry*; D005260:Female; D006801:Humans; D007797:Laminin / Q000032:analysis*; D016912:Levonorgestrel / Q000009:adverse effects*; D014592:Uterine Hemorrhage / Q000209:etiology*
D003271:Contraceptive Agents, Female; D007797:Laminin; D016912:Levonorgestrel