Activated protein C resistance in antiphospholipid thrombosis syndrome.
OBJECTIVE
To explore the correlation between antiphospholipid antibodies (APA), activated protein C resistance (APCR) and antiphospholipid thrombosis (APL-T) syndrome and further investigate the mechanism of thrombosis in APL-T syndrome.


METHODS
ELISA, PTT-LA and APTT +/- APC methods were used to detect anticardiolipin antibodies (ACA), lupus anticoagulants (LA) and APC R in 20 APL-T syndrome patients.


RESULTS
Twenty patients were diagnosed as APL-T. ACA-IgG, M and LA are strongly associated with APL-T. The incidence of APCR in APL-T (75%) was significantly higher than that of the normal group (5%).


CONCLUSIONS
There was high prevalence of APCR in APL-T, which was strongly associated with LA. It is proposed that acquired APCR induced by APA is a key to understanding thrombosis in Chinese APL-T patients.
Wu
J
J
Anhui Provincial Hospital, Hefei 230001, China.
Zhou
Z
Z
Li
X
X
Li
X
X
Chen
Y
Y
Wang
G
G
Wang
Z
Z
D020016:Activated Protein C Resistance / Q000097:blood*; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood*
D016682:Lupus Coagulation Inhibitor