title: Expression of CD44 in synovium of rabbits with chronic arthritis induced by immunization with Escherichia coli.
abstract: OBJECTIVE
  To investigate the expression of CD44 and its role in experimental chronic arthritis in rabbits.
  
  
  METHODS
  Rabbits were immunized with Escherichia coli 0:14 for short (4 mo) and long (8-10 mo) periods. Immunohistochemical staining was performed on knees, using anti-CD44 antibodies.
  
  
  RESULTS
  Lymphocyte infiltration in the synovium was found in 30.0% of rabbits after short term immunization, and the rate increased to 58.3% after longterm immunization. CD44 was present in synovial lining cells in 30.0% of rabbits after short term immunization, and it increased significantly (p < 0.05) after longterm immunization (66.7%). CD44 was also observed in lymphocytes in knee synovium after longterm immunization (25.0%).
  
  
  CONCLUSIONS
  CD44 in lining cells might play a role in promoting chronic arthritis in rabbits immunized with E. coli.
authors.affiliation: Department of Orthopaedic Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: R
authors.initials: R
authors.lastname: Okamoto
authors.forename: N
authors.initials: N
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Noyori
authors.forename: T
authors.initials: T
authors.lastname: Koshino
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D004926:Escherichia coli / Q000276:immunology / Q000472:pathogenicity; D005260:Female; D018960:Hyaluronan Receptors / Q000032:analysis / Q000096:biosynthesis*; D006965:Hyperplasia / Q000473:pathology; D007114:Immunization; D007150:Immunohistochemistry; D007719:Knee Joint / Q000378:metabolism* / Q000473:pathology; D011817:Rabbits; D012217:Rheumatoid Factor / Q000097:blood; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology
chemical_list: D018960:Hyaluronan Receptors; D012217:Rheumatoid Factor