[Effect of vilon and epithalone on induction and growth of induced bladder neoplasms in rats].
Experimental data on the effect of peptides--Vilon (Lys-Glu) and Epitalon (Ala-Glu-Asp-Gly)--on induction of urinary bladder tumors in rats are presented. Treatment with Vilon was followed by a significant fall in tumor incidence in 56% of experimental animals, as compared with 75.5% in control, as well as inhibition of early-onset neoplastic changes in the bladder mucosa. No inhibitory effect of Epitalon was recorded.
Pliss
G B
GB
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Mel'nikov
A S
AS
Malinin
V V
VV
Khavinson
V Kh
VKh
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity; D004151:Dipeptides / Q000494:pharmacology*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D002273:Carcinogens; D004151:Dipeptides; D009842:Oligopeptides; D002085:Butylhydroxybutylnitrosamine; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine
Vliianie vilona i épitalona na vozniknovenie i razvitie indutsirovannykh opukholeĭ mochevogo puzyria u krys.