Reversible fetal hydrops associated with indomethacin use.
BACKGROUND
Ductus arteriosus constriction is a known complication of exposure to indomethacin in utero. Nonimmune hydrops associated with indomethacin use has been reported in only six cases, all twins over 32 weeks' gestation.


METHODS
We present a case of fetal hydrops associated with tricuspid regurgitation and ductal constriction developing within 30 hours of instituting indomethacin tocolysis in a 28-week singleton gestation. Discontinuation of indomethacin resulted in partial resolution of these findings 72 hours later. A normal infant was delivered subsequently.


CONCLUSIONS
Ultrasonographic screening for signs of constriction of the ductus arteriosus should be done within 48 hours of instituting indomethacin therapy at any gestational age.
Pratt
L
L
Department of Obstetrics and Gynecology, University of Wisconsin-Madison, 53715, USA.
Digiosia
J
J
Swenson
J N
JN
Trampe
B
B
Martin
C B
CB
D000328:Adult; D004373:Ductus Arteriosus / Q000187:drug effects; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D007213:Indomethacin / Q000009:adverse effects*; D011247:Pregnancy; D013997:Time Factors; D015149:Tocolytic Agents / Q000009:adverse effects*; D014262:Tricuspid Valve Insufficiency / Q000139:chemically induced; D016216:Ultrasonography, Prenatal
D015149:Tocolytic Agents; D007213:Indomethacin