title: Magnetic resonance imaging and magnetic resonance sialography of parotid glands in primary Sjogren's syndrome.
abstract: OBJECTIVE
  To look for structural parotid gland changes on magnetic resonance (MR) imaging and MR sialography of primary Sjögren's syndrome (SS) patients and healthy control subjects and to compare these methods with each other.
  
  
  METHODS
  MR imaging and MR sialography of both parotid glands were performed on 26 patients and 7 healthy controls. Bilateral surface coils were used to obtain high spatial resolution.
  
  
  RESULTS
  Twenty-two of the 26 patients had abnormalities on MR imaging. Twenty-one had a nodular or dendritic parenchymal pattern, 5 had cavities, and 6 had duct dilatations. On MR sialography, 25 of the 26 patients had abnormalities of the ducts, and 16 of them also had cavities. One patient and all 7 controls had normal results with both methods. The structural appearance of the parotid glands on MR images had marginal linear association with the duct system changes but no correlation with the cavitary changes seen on MR sialography. Furthermore, duct system abnormalities did not correlate with cavitary changes. Both parenchymal and sialographic abnormalities were associated with the presence of Ro/SSA antibodies but not with age of the patient, disease duration, salivary flow rate, or the presence of hypergammaglobulinemia or extraglandular manifestations.
  
  
  CONCLUSIONS
  MR imaging and MR sialography are noninvasive methods that provide definitive information of morphologic changes in parotid glands and can be used as diagnostic indicators of primary SS. Because these methods give information on different aspects of glandular pathology, both should be performed when evaluating parotid glands of SS patients. MR sialography is more sensitive, but conventional MR imaging gives complementary information on the progressive pathologic changes of glandular parenchyma.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Oulu University Hospital, University of Oulu, Finland. raija.niemela@oulu.fi
authors.forename: R K
authors.initials: RK
authors.lastname: Niemelä
authors.forename: E
authors.initials: E
authors.lastname: Pääkkö
authors.forename: I
authors.initials: I
authors.lastname: Suramo
authors.forename: R
authors.initials: R
authors.lastname: Takalo
authors.forename: M
authors.initials: M
authors.lastname: Hakala
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000000981:diagnostic imaging* / Q000473:pathology*; D012796:Sialography / Q000379:methods*; D012859:Sjogren's Syndrome / Q000000981:diagnostic imaging* / Q000473:pathology*