title: From chicken coops to genome maps: generating phenotype from the molecular blueprint.
abstract: The tools of molecular and cellular biology can be used to precisely describe traits in terms of a sequence of nucleic acids when their molecular and cellular bases are well understood. The entire genome of elite production birds, however, cannot be written as a series of A's, T's, C's, and G's because the interaction between alleles at the same and different loci is too large and there is likely to be many genotypes that encode the same production trait phenotype. A first draft of the genetic map of the chicken is anticipated within the next few years, but a complete molecular description of the genome of birds with elite production characteristics is not anticipated in the near future. Quantitative genetics will remain the cornerstone of breeding programs for production traits. Novel sequences encoding traits such as enhanced nutritional capability (e.g., expression of phytase) and resistance to specific diseases could be introduced into lines of chickens using the tools of molecular and cellular biology. Cloning could be used by the poultry industry to disperse highly desirable genotypes without the need for grandparent and parent flocks for multiplication.
authors.affiliation: Origen Therapeutics, Burlingame, California 94010, USA. retches@origentherapeutics.com
authors.forename: R J
authors.initials: RJ
authors.lastname: Etches
mesh_terms: D000818:Animals; D001709:Biotechnology; D001947:Breeding; D002645:Chickens / Q000235:genetics*; D002874:Chromosome Mapping / Q000662:veterinary*; D019976:Cloning, Organism / Q000662:veterinary; D005260:Female; D016678:Genome; D005838:Genotype; D008297:Male; D010641:Phenotype; D011201:Poultry Diseases / Q000235:genetics / Q000517:prevention & control; D019655:Quantitative Trait, Heritable