title: Serum S100B levels in patients with lupus erythematosus: preliminary observation.
abstract: S100B is an astrocytic calcium-binding protein which has been proposed as a biochemical marker of brain damage or dysfunction in acute and chronic diseases. We investigated whether serum S100B levels could be related to systemic lupus erythematosus (SLE) activity. Patients were grouped as having inactive SLE (ISLE), active SLE without central nervous system (CNS) involvement (ASLE), or active SLE with unequivocal neurologic or psychiatric manifestation (NPSLE). The control group consisted of age- and sex-matched healthy blood donors. S100B levels were determined using a luminescence immunoassay. All SLE groups had higher levels of serum S100B than the control group. Among the SLE groups, significantly higher levels of serum S100B protein were found in the NPSLE group than in the ISLE and ASLE groups, and there was no significant difference in S100B levels between the ISLE and ASLE groups. These preliminary results point to a putative relevance of serum S100B protein levels in SLE patients, specifically concerning CNS involvement present in this disease.
authors.affiliation: Laboratório Municipal de Novo Hamburgo, Novo Hamburgo, Brazil. roska@vortex.ufrgs.br
authors.forename: Luis V C
authors.initials: LV
authors.lastname: Portela
authors.forename: João C T
authors.initials: JC
authors.lastname: Brenol
authors.forename: Roger
authors.initials: R
authors.lastname: Walz
authors.forename: Marino
authors.initials: M
authors.lastname: Bianchin
authors.forename: Adriano B L
authors.initials: AB
authors.lastname: Tort
authors.forename: Ubirajara P
authors.initials: UP
authors.lastname: Canabarro
authors.forename: Simone
authors.initials: S
authors.lastname: Beheregaray
authors.forename: João A
authors.initials: JA
authors.lastname: Marasca
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Xavier
authors.forename: Eurico C
authors.initials: EC
authors.lastname: Neto
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Gonçalves
authors.forename: Diogo O
authors.initials: DO
authors.lastname: Souza
mesh_terms: D000328:Adult; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications; D020945:Lupus Vasculitis, Central Nervous System / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins
chemical_list: D002135:Calcium-Binding Proteins; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human