Seizure anticipation by non-linear EEG analysis.
The study of dynamical changes in the neural activity preceding an epileptic seizure allows the characterization of a pre-ictal state several minutes prior to seizure onset. This opens new perspectives for studying the mechanisms of epileptogenesis as well as for possible therapeutic interventions which represent a major breakthrough. In this review we present and discuss the results from our group in this domain using nonlinear analysis of brain signals, as well as the limitations of this method and the remaining questions.
Quyen
M le V
Mle V
LENA, Laboratoire de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, Hôpital de la Pitié-Salpêtrière, 4, bd de l'Hôpital, 75651 Paris Cedex 13, France.