[Effect of Panax notoginseng saponin on Ca2+, CaM in craniocerebral injury].
OBJECTIVE
To explore the change of nerve cell Ca(2+)-overload, Ca(2+)-CaM and the effect of Panax Notoginseng saponin (PNS) on it in craniocerebral injury.


METHODS
Blood and brain contents of Ca2+, CaM were examined by radio-immunoassay (RIA) and atomic absorption spectrometry(AAS), and effect of PNS on these parameters was observed in craniocerebral injury rabbits.


RESULTS
The levels of Ca2+ and CaM in blood and those in brain were significantly positively correlated. PNS could reduce Ca2+ and CaM contents in blood and in cerebral tissue.


CONCLUSIONS
PNS could block the Ca(2+)-overload and Ca(2+)-CaM complex production in nerve cell after cranial cerebral injury, thereby to protect the injured brain in a certain degree. Blood CaM level is an objective index for assessment of Ca(2+)-overload in nerve cell.
Han
J
J
Department of Neurosurgery, 477 Hospital of PLA, Xiangfan, Hubei, China.
Hu
W
W
Sun
Z
Z
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D008297:Male; D011897:Random Allocation; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D002147:Calmodulin; D004365:Drugs, Chinese Herbal; D012503:Saponins; D002118:Calcium