[Quantitive study of 6-keto-prostaglandin F1 alpha and thromboxane B2 in human pulp].
OBJECTIVE
To study the change of the levels of 6-keto-prostaglandin F1 alpha (6-K-PGF1 alpha) and thromboxane B2 (TXB2) in deep caries and pulpitis pulp.


METHODS
The levels of 6-K-PGF1 alpha and TXB2 were determined by radioimmunoassay (RIA) in 44 pulp tissues from subjects with healthy pulp (H), deep caries (DC), chronic pulpitis (CP) and acute pulpitis(AP). The 6-K-PGF1 alpha/TXB2 ratio(K/T) was calculated.


RESULTS
The lconcentrations of 6-K-PGF1 alpha in Group AP were highest and those in Group H were lowest. The levels of TXB2 in Group DC were lower than Group CP and those in Group H were lowest. Significant differences in K/T ratio were found among the groups except those between Group H and DC. The value of Group AP was highest and that of Group CP was lowest.


CONCLUSIONS
The dysbolism and dysequilibrium of PGI2 and TXA2 may be closely related to the genesis of pulp diseases.
Dong
Y
Y
School of Stomatology, China Medical University, Shenyang 110002.
Zhou
J
J
Pan
Y
Y
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D003731:Dental Caries / Q000378:metabolism / Q000473:pathology*; D003782:Dental Pulp / Q000737:chemistry / Q000473:pathology; D006801:Humans; D011671:Pulpitis / Q000378:metabolism / Q000473:pathology*; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000378:metabolism*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha