title: Chiral amplification of oligopeptides in two-dimensional crystalline self-assemblies on water.
abstract: Differences in the two-dimensional packing arrangements of racemic and enantiomeric crystalline self-assemblies on the water surface of amphiphilic activated analogs of lysine and glutamic acid have been used to prepare oligopeptides of homochiral sequence and oligopeptides of single handedness from chiral nonracemic mixtures. The crystalline structures on the water surface were determined by grazing incidence x-ray diffraction and the diastereomeric composition of the oligopeptides by matrix-assisted laser desorption time-of-flight mass spectrometry with enantio-labeling. These results suggest that reactivity of ordered clusters at interfaces might have played a role in the generation of early homochiral biopolymers.
authors.affiliation: Department of Materials and Interfaces, Weizmann Institute of Science, 76100 Rehovot, Israel.
authors.forename: Helmut
authors.initials: H
authors.lastname: Zepik
authors.forename: Edna
authors.initials: E
authors.lastname: Shavit
authors.forename: Mao
authors.initials: M
authors.lastname: Tang
authors.forename: Torben R
authors.initials: TR
authors.lastname: Jensen
authors.forename: Kristian
authors.initials: K
authors.lastname: Kjaer
authors.forename: Gérard
authors.initials: G
authors.lastname: Bolbach
authors.forename: Leslie
authors.initials: L
authors.lastname: Leiserowitz
authors.forename: Isabelle
authors.initials: I
authors.lastname: Weissbuch
authors.forename: Meir
authors.initials: M
authors.lastname: Lahav
mesh_terms: D001704:Biopolymers; D003460:Crystallization; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D008239:Lysine / Q000031:analogs & derivatives* / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013237:Stereoisomerism; D014867:Water; D014961:X-Ray Diffraction
chemical_list: D001704:Biopolymers; D009842:Oligopeptides; D014867:Water; D018698:Glutamic Acid; D008239:Lysine