title: Cell cycle dysregulation by HTLV-I: role of the tax oncoprotein.
abstract: HTLV-I is a human retrovirus which is the etiological agent for adult T-cell leukemia. The virus encodes a 40 kDa oncoprotein, Tax, which has no cellular counterpart. Findings from several laboratories over the past decade have shown that over-expression of the Tax oncoprotein is wholly sufficient to transform animal cells. Emerging evidence supports that Tax transforms cells through dysregulation of several cell cycle checkpoints. Here, we review extant data on how Tax targets cyclins, inhibitors of cyclin dependent kinase, as well as cellular sentries for DNA-damage.
authors.affiliation: Laboratoire de Recombinaison et Expression Genetique, Institut Pasteur, 28, rue du Dr Roux. 75724 Paris cedex 15, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Neuveut
authors.forename: Kuan-Teh
authors.initials: KT
authors.lastname: Jeang
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D016356:Gene Products, tax / Q000378:metabolism / Q000502:physiology*; D016355:Genes, pX / Q000502:physiology; D015368:Human T-lymphotropic virus 1 / Q000502:physiology*; D006801:Humans
chemical_list: D016356:Gene Products, tax