[Experimental study on effect of guyubao in promoting the fracture healing in kidney deficiency rabbits].
OBJECTIVE
To study the effect of Guyubao (GYB) in promoting the fracture healing of Kidney deficiency (KD) rabbits.


METHODS
Fifty-seven rabbits were randomly divided into three groups: The blank group (A), the control group (B) and the experimental group (C). After the periosteum was peeled off, 0.73 cm middle section defects on both radius were removed. One week after operation, the experiment was begun: Group A was fed normally; group B fed normally plus 6 mg/(kg.d) prednisolone; group C fed with food mixed with GYB and 6 mg/(kg.d) prednisolone. The general state and body weight were observed. The rabbits were sacrificed at three and six weeks after the beginning of experiment. Both radius were observed with X-ray and histologic examination.


RESULTS
In group A, no KD appeared, group B gradually developed KD, and mild KD appeared in group C but adjusted rapidly. The healing of radial defect in order were C, A, B from higher to lower degree.


CONCLUSIONS
The results revealed that the GYB could correct the KD and promote fracture healing.
Guo
J
J
Luoyang Institute of Orthopedics and Traumatology, Henan (471002).
Mao
S
S
Zhao
R
R
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D017102:Fracture Healing / Q000187:drug effects*; D007674:Kidney Diseases / Q000503:physiopathology; D008297:Male; D011817:Rabbits; D011885:Radius Fractures / Q000503:physiopathology*; D011897:Random Allocation; D016711:Yang Deficiency / Q000503:physiopathology*
D004365:Drugs, Chinese Herbal