Increased CSF levels of prostaglandin E(2) in variant Creutzfeldt-Jakob disease.
The concentration of the cyclooxygenase product prostaglandin E(2) was sixfold higher in CSF samples from 18 cases of variant Creutzfeldt-Jakob disease (CJD) than in a group of eight subjects with other noninflammatory neurologic diseases, and comparable to those found in a group of six patients affected by diseases with a known inflammatory component. This finding suggests that cyclooxygenase activity may have a role in variant CJD pathogenesis, as previously reported in sporadic CJD.
Minghetti
L
L
Laboratory of Pathophysiology, Istituto Superiore di Sanità, Rome, Italy.
Cardone
F
F
Greco
A
A
Puopolo
M
M
Levi
G
G
Green
A J E
AJ
Knight
R
R
Pocchiari
M
M
D000328:Adult; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid; D015232:Dinoprostone / Q000134:cerebrospinal fluid*; D006801:Humans; D008875:Middle Aged
C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D015232:Dinoprostone