title: Effect of ramipril in a patient with glycogen storage disease type I and nephrotic-range proteinuria.
abstract: We studied the effect of ramipril on urinary protein excretion and arterial pressure in a 27-year-old patient with GSD Ia and heavy proteinuria (2-3 g /24 h). Ramipril therapy resulted in an important reduction of proteinuria (0.3-0.5 g/24 h): no changes were observed in arterial pressure and renal function during the 12-month follow-up. We conclude that treatment with ramipril can be employed effectively and safely in GSD Ia patients with nephrotic-range proteinuria.
authors.affiliation: Pediatric Nephrology Unit, Department of Pediatrics, University of Florence, Florence, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Pela
authors.forename: M A
authors.initials: MA
authors.lastname: Donati
authors.forename: E
authors.initials: E
authors.lastname: Zammarchi
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005953:Glycogen Storage Disease Type I / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D009401:Nephrosis / Q000188:drug therapy*; D011507:Proteinuria / Q000188:drug therapy*; D017257:Ramipril / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D017257:Ramipril