title: Effects of type 1A serotonin receptor agonist 8-OH-DPAT on immune response.
abstract: The selective agonist of type 1 A serotonin receptors 8-hydroxy-2-(di-n-propyl-amino)tetra-lin (8-OH-DPAT) suppressed the immune response. Intraperitoneal administration of 1 mg/kg 8-OH-DPAT to Wistar rats over 2 days after immunization decreased the count of plaque- and rosette-forming cells on day 5. Our results indicate that type 1A serotonin receptors are involved in the realization of the immunosuppressive effects of the serotoninergic system.
authors.affiliation: Laboratory of Mechanisms of Neurochemical Modulation, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. galina@iph.ma.nsc.ru
authors.forename: G V
authors.initials: GV
authors.lastname: Idova
authors.forename: M A
authors.initials: MA
authors.lastname: Cheido
authors.forename: E N
authors.initials: EN
authors.lastname: Zhukova
authors.forename: E L
authors.initials: EL
authors.lastname: Al'perina
authors.forename: L V
authors.initials: LV
authors.lastname: Devoino
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D017366:Serotonin Receptor Agonists; D003533:Cyproheptadine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin