[Association of beta 3-adrenergic receptor gene with obesity in patients with type 2 diabetes mellitus].
OBJECTIVE
To investigate the association between the mutation of beta 3-adrenergoc receptor gene and obesity in patients with type 2 diabetes.


METHODS
Body mass, waist-hip ratio, blood pressure and blood lipids were measured in 154 type 2 diabetic patients. Polymerase chain reaction and the restriction fragment length polymorphism analysis were used to determine the wild, heterozygous and homozygous forms of beta 3-adrenergoc receptor gene.


RESULTS
The frequency of the Trp64Arg mutation was 42.5% and the frequency of Arg64 allele was 22.6%. The mutation frequency of the genetic types was significantly different between the obese and non-obese type 2 diabetes mellitus patients. The body mass, systolic blood pressure, diastolic blood pressure, HDL-cholesterol were significantly different, when those with Trp64Arg heterozygous were compared with those with Trp64 homozygous.


CONCLUSIONS
The genetic mutation of beta 3-adrenegoc receptor in patients with type 2 diabetes is probably related to obesity.
Chen
Y
Y
Department of Nutriology, Tourism and Chinese Cuisine College of Yangzhou University, Yangzhou 225001, China.
Xu
Y
Y
Zhou
L
L
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D017354:Point Mutation; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*
D008076:Cholesterol, HDL; D005819:Genetic Markers; D022702:Receptors, Adrenergic, beta-3