Trospium chloride--an effective drug in the treatment of overactive bladder and detrusor hyperreflexia.
Trospium chloride (TCL), a quaternary ammonium derivative of nortropanol, has been evaluated in a number of clinical and pharmacological studies. Selected pharmacological and clinical pharmacokinetic data are discussed as providing a basis for a better interpretation and understanding of the clinical trial results. An overview of the results of 20 clinical trials and post-marketing surveillance studies including more than 10000 patients is presented.
Höfner
K
K
Urologische Klinik, Ev Krankenhaus Oberhausen, Germany. klaus.hoefner@freenet.de
Oelke
M
M
Machtens
S
S
Grünewald
V
V
D001561:Benzilates; D006801:Humans; D018727:Muscarinic Antagonists / Q000494:pharmacology* / Q000627:therapeutic use*; D009130:Muscle, Smooth / Q000187:drug effects*; D009662:Nortropanes / Q000494:pharmacology* / Q000627:therapeutic use*; D012021:Reflex, Abnormal / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects; D001745:Urinary Bladder Diseases / Q000188:drug therapy*
D001561:Benzilates; D018727:Muscarinic Antagonists; D009662:Nortropanes; C003330:trospium chloride