[Relationship between follicular development and insulin like growth factor I receptor in stimulated cycles].
OBJECTIVE
To investigate the number of follicles and insulin-like growth factor I receptor (IGF-I R) in stimulated cycles.


METHODS
IGF-I R mRNA and IGF-I R in granulosa cells obtained during oocyte retrieval were respectively measured by reverse transcript polymerase chain reaction (RT-PCR) and Western blot technique.


RESULTS
The expression of IGF-I R mRNA in poor responders (follicles < or = 3) was much lower than in normal responders (follicles 4-13) and high responders (follicles > or = 14) (1.70 +/- 0.23, 2.92 +/- 0.49, 4.22 +/- 1.50 respectively). Similar results were obtained for IGF-I R (1.32 +/- 0.31, 2.01 +/- 0.72, 4.39 +/- 2.31 respectively).


CONCLUSIONS
The expression of IGF-I R correlated with the effects of gonadotropin hormone on follicular development.
Chen
D
D
Department of Gynecology, Affiliated Obstetrics and Gynecology Hospital, Faculty of Medicine, Zhejiang University, Hangzhou 310006, China.
Shi
Y
Y
Chen
H
H
D000328:Adult; D005260:Female; D006801:Humans; D006080:Ovarian Follicle / Q000254:growth & development*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D013480:Superovulation / Q000502:physiology*
D017526:Receptor, IGF Type 1