Effects of type 1A serotonin receptor agonist 8-OH-DPAT on immune response.
The selective agonist of type 1 A serotonin receptors 8-hydroxy-2-(di-n-propyl-amino)tetra-lin (8-OH-DPAT) suppressed the immune response. Intraperitoneal administration of 1 mg/kg 8-OH-DPAT to Wistar rats over 2 days after immunization decreased the count of plaque- and rosette-forming cells on day 5. Our results indicate that type 1A serotonin receptors are involved in the realization of the immunosuppressive effects of the serotoninergic system.
Idova
G V
GV
Laboratory of Mechanisms of Neurochemical Modulation, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. galina@iph.ma.nsc.ru
Cheido
M A
MA
Zhukova
E N
EN
Al'perina
E L
EL
Devoino
L V
LV
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013997:Time Factors
D017366:Serotonin Receptor Agonists; D003533:Cyproheptadine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin