Severe evolution of chronic hepatitis C in renal transplantation: a case control study.
BACKGROUND
To evaluate the impact of kidney transplantation on histopathological progression of hepatitis C virus (HCV)-related liver disease.


METHODS
In a retrospective study, 28 HCV-positive renal transplant patients, who underwent two sequential liver biopsies with a mean of 7.1+/-4.0 years, were compared with 28 matched immunocompetent controls.


RESULTS
According to the Metavir score, the initial and final activity scores (from 0 to 3) increased from 0.2+/-0.4 to 1.4+/-1.1 (P<0.001) and those of fibrosis (from 0 to 4) from 0.5+/-0.5 to 2.0+/-1.4 (P<0.001) in the transplanted group, respectively, whereas the respective differences were not significant in the control group. The yearly progression rate of activity and fibrosis was significantly higher in the renal transplant group as compared with the immunocompetent group: 0.26+/-0.41 vs 0.01+/-0.19 (P<0.01) and 0.26+/-0.35 vs 0.05+/-0.21 (P<0.03), respectively. Twenty (71.5%) and 14 (50.0%) of the renal allograft recipients had activity and fibrosis progression as compared with four (16%) (P<0.001) and four (16%) (P<0.01) in immunocompetent patients; six kidney recipients (21.4%) evolved to cirrhosis vs only one in the control group (3.6%) (P=0.07). Liver-related mortality was significantly higher during the follow-up period in renal transplant patients than in the control group (10 vs 0%) (P<0.05).


CONCLUSIONS
Using conventional immunosuppressive regimen, renal transplantation is associated with a more severe evolution of chronic hepatitis C as compared with HCV-infected immunocompetent subjects. Thus, the histopathological evaluation should be performed and anti-viral therapy discussed before renal transplantation.
Zylberberg
Hervé
H
Service d'Hépatologie et INSERM U-370, Hôpital Saint-Louis, Paris, France.
Nalpas
Bertrand
B
Carnot
Françoise
F
Skhiri
Habib
H
Fontaine
Hélène
H
Legendre
Christophe
C
Kreis
Henri
H
Bréchot
Christian
C
Pol
Stanislas
S
D000328:Adult; D005260:Female; D019698:Hepatitis C, Chronic / Q000209:etiology* / Q000473:pathology / Q000821:virology; D006801:Humans; D007108:Immune Tolerance; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D012189:Retrospective Studies; D019562:Viral Load