title: Outcome of curative management of malignant tumours of the parotid gland.
abstract: OBJECTIVE
  The optimal management of malignant parotid gland tumours remains to be defined precisely. Specifically, a further understanding of the tumour features that influence treatment outcome is needed.
  
  
  METHODS
  A retrospective review was conducted on 184 patients who were registered at the Princess Margaret Hospital with a diagnosis of a primary malignant parotid gland tumour.
  
  
  RESULTS
  All patients were initially managed with a parotidectomy, and postoperative x-ray radiation therapy (XRT) was administered to 159 patients. The actuarial 5-year cause-specific survival and locoregional control rates were 76% and 81%, respectively. The survival and locoregional control rates for patients treated with surgery alone versus surgery plus postoperative XRT were not statistically different. A multiple regression analysis identified only age and tumour category to be independently significant prognostic factors for both survival and locoregional control.
  
  
  CONCLUSIONS
  We would recommend that patients with malignant parotid gland tumours be managed with parotidectomy, followed by postoperative XRT for tumours with residual disease, aggressive histology, and/or positive lymph nodes.
authors.affiliation: Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Ontario.
authors.forename: P
authors.initials: P
authors.lastname: Kirkbride
authors.forename: F F
authors.initials: FF
authors.lastname: Liu
authors.forename: B
authors.initials: B
authors.lastname: O'Sullivan
authors.forename: D
authors.initials: D
authors.lastname: Payne
authors.forename: P
authors.initials: P
authors.lastname: Warde
authors.forename: P
authors.initials: P
authors.lastname: Gullane
authors.forename: M
authors.initials: M
authors.lastname: Pintilie
authors.forename: T J
authors.initials: TJ
authors.lastname: Keane
authors.forename: B
authors.initials: B
authors.lastname: Cummings
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D010306:Parotid Gland / Q000601:surgery; D010307:Parotid Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome