title: Inhibition by ticlopidine and its derivatives of human liver cytochrome p450. Mechanism-based inactivation of CYP 2C19 by ticlopidine.
authors.affiliation: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université René Descartes, CNRS UMR 8601, Paris, France.
authors.forename: N T
authors.initials: NT
authors.lastname: Ha-Duong
authors.forename: S
authors.initials: S
authors.lastname: Dijols
authors.forename: A C
authors.initials: AC
authors.lastname: Macherey
authors.forename: P M
authors.initials: PM
authors.lastname: Dansette
authors.forename: D
authors.initials: D
authors.lastname: Mansuy
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases; D065731:Cytochrome P-450 CYP2C19; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015394:Molecular Structure; D009249:NADP / Q000378:metabolism; D013988:Ticlopidine / Q000737:chemistry / Q000378:metabolism*
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D005978:Glutathione; D013988:Ticlopidine