[Relationship of cytokines and cold-heat syndrome differentiation in patients of duodenal ulcer].
OBJECTIVE
To explore the relationship of cytokines and Cold-Heat Syndrome in patients of duodenal ulcer.


METHODS
Cold-Heat Syndrome Differentiation was done in 48 patients of duodenal ulcer, and the levels of interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor (TNF), malonyldialdehyde (MDA), marrow peroxidase (MPO) in gastric mucosa biopsy were measured and compared with those of 10 normal subjects.


RESULTS
Levels of IL-8, TNF, MPO and MDA in Heat Syndrome were higher than those in Cold Syndrome (P < 0.05), while IL-6 level showed no significant relationship with Cold-Heat Syndrome.


CONCLUSIONS
Cytokines IL-8, TNF, MPO and MDA are correlated with Cold-Heat Syndrome in duodenal ulcer patients and which might be one of the molecular mechanisms of Cold-Heat Syndrome Differentiation.
Zhang
X
X
Institute of Integrated Traditional Chinese and Western Medicine, First Hospital of Beijing Medical University, Beijing (100034).
Ji
B
B
Chen
B
B
D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde