[Increase in the level of metallothioneins in mouse liver after administration of cadmium chloride does not protect from combined radiation-thermal injury].
Effects of MT preinduction by cadmium chloride on the resistance to combined injury such as whole body gamma-irradiation at the dose of 7 Gy + thermal burn were investigated in (CBA x C57BL6)F1 mice. Normal level of MT markedly increased in mice liver but not in bone marrow cells if Cd was given subcutaneously (1 mg/kg) prior to combined injury. However, preinduction of MT did not reduce the lethal effects and bone marrow devastation caused by combined radiation injury. No differences in the leukopenia degree and in CFU-s number were observed between control and MT-induced mice. In summary, Cd-induced MT elevation in mice liver does not protect against the toxic and lethal effects caused by combined radiation injury.
Budagov
R S
RS
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249036 Russia. budagov@obninsk.com
Ul'ianova
L P
LP
Smoryzanova
O A
OA
Rott
G M
GM
D000818:Animals; D002056:Burns / Q000378:metabolism / Q000517:prevention & control*; D019256:Cadmium Chloride / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008668:Metallothionein / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control*; D014916:Whole-Body Irradiation
D008668:Metallothionein; D019256:Cadmium Chloride
Povyshenie soderzhaniia metalothioneinov v pecheni mysheĭ posle vvedeniia khloristogo kadmiia ne zashchishchaet ot kombinirovannykh radiatsionno-termicheskikh porazheniĭ.