title: Novel amidine conjugates of the ornithine moiety of the macrocyclic antifungal lipopeptidolactone FR901469.
authors.affiliation: Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan. david_barrett@po.fujisawa.co.jp
authors.forename: D
authors.initials: D
authors.lastname: Barrett
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: E
authors.initials: E
authors.lastname: Watabe
authors.forename: K
authors.initials: K
authors.lastname: Maki
authors.forename: F
authors.initials: F
authors.lastname: Ikeda
mesh_terms: D000578:Amidines / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D006461:Hemolysis / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D009952:Ornithine / Q000737:chemistry / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D055666:Lipopeptides
chemical_list: D000578:Amidines; D000935:Antifungal Agents; D047630:Depsipeptides; D009952:Ornithine; D010456:Peptides, Cyclic; C417112:FR 901469; D055666:Lipopeptides