[Clinical and experimental study on zhixie buye mixture in treating infantile diarrhea complicated with dehydration].
OBJECTIVE
To observe the therapeutic effect of Zhixie Buye mixture (ZXBYM) on infantile diarrhea patient with mild and middle degree of dehydration.


METHODS
The controlled observation method was adopted in the clinical and experimental study.


RESULTS
There was no significant difference in the treatment of dehydration between the ZXBYM group and ORS group (P > 0.05), while it was more effective for ZXBYM to eliminate the symptoms such as vomiting and abdominal distension (P < 0.01). In addition, it was confirmed that the ion concentration of sodium, potassium, chlorine, glucose and osmotic pressure in the mixture was similar to those in ORS. Animal experiment showed that it has the effect of rat intestine peristalsis suppression and water absorption promotion in colon for ZXBYM. And there was statistical difference in antidiarrhea effect between the mixture and ORS (P < 0.01).


CONCLUSIONS
The ZXBYM is an effective mixture in the treatment of diarrhea with dehydration. It has a good prospect of development and application.
Zhu
J
J
Shenzhen Children Hospital, Guangdong (518026).
Zhong
C
C
Sun
D
D
D000818:Animals; D002675:Child, Preschool; D003681:Dehydration / Q000188:drug therapy* / Q000209:etiology; D003968:Diarrhea, Infantile / Q000150:complications / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D051379:Mice; D010528:Peristalsis / Q000187:drug effects; D008517:Phytotherapy; D051381:Rats
D004365:Drugs, Chinese Herbal