[Comparative study on therapeutic effects of gandou tablet I and dimercaptosuccinate acid in treating Wilson disease].
OBJECTIVE
To compare the effects of Gandou I (GD, a Chinese herbal preparation) and dimercaptosuccinate acid (DMSA) in treating Wilson disease (WD).


METHODS
Ninety-four patients with WD were divided into 2 groups, 32 cases in the GD group and 62 in the DMSA group, they were treated with GD and DMSA respectively. The therapeutic course was 4 weeks for both groups. Modified Goldstein's Degree was adopted to evaluate the clinical effect.


RESULTS
The total effective rate of the GD group was 71.9%, which was similar to that of the DMSA group (77.4%, P > 0.05). But the adverse reaction occurred in the latter group was more than that in the former.


CONCLUSIONS
GD is a low toxic and highly effective drug for long-term treatment of WD.
Han
Y
Y
Institute of Neurology, Anhui College of TCM, Hefei (230031).
He
G
G
Wang
X
X
D000293:Adolescent; D000328:Adult; D002614:Chelating Agents; D002648:Child; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006801:Humans; D008297:Male; D004113:Succimer / Q000627:therapeutic use*; D013607:Tablets
D002614:Chelating Agents; D004365:Drugs, Chinese Herbal; D013607:Tablets; D004113:Succimer