title: Human pulpal response to direct pulp capping with an adhesive system.
abstract: OBJECTIVE
  To evaluate clinically and microscopically the human pulp response when directly capped with an adhesive system or calcium hydroxide over short (9-12 days) and long (53-204 days) experimental periods.
  
  
  METHODS
  Fifty-one sound human premolars scheduled for orthodontic extraction, had their pulp horns gently exposed with a diamond point. Debris in the pulp wound was washed out with a sterile saline solution. The pulps were then capped with either an adhesive system (Scotchbond Multi-Purpose Plus) or calcium hydroxide. All teeth were subsequently restored with resin-based composite (Z-100) according to the manufacturer's instructions. After the experimental periods, the teeth were extracted and processed for light microscopic examination.
  
  
  RESULTS
  Short-term: the pulp tissue capped with SBMP-P exhibited dilated and congested blood vessels associated with a moderate inflammatory response and blanching of pulp cell nuclei. Long-term: no evidence of healing and bridge formation was observed. A persistent mild inflammatory pulp response was present. Micro-abscesses were detected in three cases associated with bacterial infiltration. Calcium hydroxide stimulated early pulp repair and dentin bridging which extended into the longest period.
authors.affiliation: Departamento de Dentística, Faculdade de Odontologia de Bauru, Universidade de São Paulo, Brazil. jcper@zaz.com.br
authors.forename: J C
authors.initials: JC
authors.lastname: Pereira
authors.forename: A D
authors.initials: AD
authors.lastname: Segala
authors.forename: C A
authors.initials: CA
authors.lastname: Costa
mesh_terms: D000038:Abscess / Q000382:microbiology; D000293:Adolescent; D001641:Bicuspid; D002126:Calcium Hydroxide / Q000627:therapeutic use; D002467:Cell Nucleus / Q000187:drug effects; D003188:Composite Resins; D003782:Dental Pulp / Q000098:blood supply / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D003785:Dental Pulp Capping; D003788:Dental Pulp Diseases / Q000382:microbiology; D003789:Dental Pulp Exposure / Q000628:therapy; D003793:Dental Restoration, Permanent; D003809:Dentin, Secondary / Q000187:drug effects; D017220:Dentin-Bonding Agents / Q000627:therapeutic use*; D004108:Dilatation, Pathologic / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D011671:Pulpitis / Q000382:microbiology / Q000473:pathology; D019279:Resin Cements / Q000627:therapeutic use; D012822:Silicon Dioxide; D014945:Wound Healing / Q000187:drug effects; D015040:Zirconium
chemical_list: D003188:Composite Resins; D017220:Dentin-Bonding Agents; D019279:Resin Cements; C425844:Scotchbond Multi-Purpose Plus; C083568:Z100 composite resin; D012822:Silicon Dioxide; D015040:Zirconium; D002126:Calcium Hydroxide