title: Hybridization properties of aromatic peptide nucleic acids: a novel class of oligonucleotide analogues.
abstract: [structure: see text] The synthesis of APNA-PNA chimeras containing all four DNA bases will be described. The hybridization properties of APNA-PNA chimeras with DNA and RNA are consistent with plausible intramolecular interactions that could preorganize the oligomers in a duplex or triplex structure with complementary DNA or RNA.
authors.affiliation: Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6.
authors.forename: Lee D
authors.initials: LD
authors.lastname: Fader
authors.forename: Youla S
authors.initials: YS
authors.lastname: Tsantrizos
mesh_terms: D004247:DNA / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D012313:RNA / Q000737:chemistry
chemical_list: D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D012313:RNA; D004247:DNA