[Disturbances of glucose metabolism in epilepsy and other neurodegenerative diseases].
Disturbances of glucose metabolism in epilepsy and other neurodegenerative diseases. Impairment of glucose and acetyl-CoA metabolism is a characteristic feature of several degenerative brain diseases. Presented paper provides experimental evidences that NO, aluminum and thiamine deficiency result in concordant disturbances in acetyl-CoA campartmentalisation as well as in nonquantal and quantal acetylcholine release in rat brain nerve terminals. Our findings indicate that simultaneous depression of acetyl-CoA synthesis and its increased utilisation for acetylcholine synthesis in the presence of neurotoxic factors is likely to make brain cholinergic neurones particularly prone to neurodegeneration.
Szutowicz
A
A
Katedra Biochemii Klinicznej, Zakład Medycyny Laboratoryjnej, Akademia Medyczna w Gdańsku. aszut@amg.gda.pl
Jankowska
A
A
Tomaszewicz
M
M
D001921:Brain / Q000378:metabolism* / Q000503:physiopathology*; D004827:Epilepsy / Q000378:metabolism* / Q000503:physiopathology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000503:physiopathology*
D005947:Glucose
Zaburzenia metabolizmu glukozy w padaczce i innych chorobach neurodegeneracyjnych.