title: Soluble adhesion molecules versus lymphoblast transformation in diagnosis of zoonotic cutaneous leishmaniasis.
abstract: Twelve parasitologically proven ZCL patients (one with non-ulcerative lesion and eleven with multiple ulcerative lesions) were subjected to estimation of the levels of lymphoblast transformation (LTT) and soluble adhesion molecules (sICAM-1 & sELAM-1 by ELISA). The results proved high percentage of LTT in relation to number and clinical picture of the ZCL lesions. As to the soluble adhesion molecules, sICAM-1 levels were significantly increased than in normal controls and correlated positively with the number of ulcerative lesions. sELAM-1 levels were not significantly increased than the normal controls, but correlated positively with the number of ulcerative lesions. Consequently, soluble adhesion molecules mainly sICAM-1 is a good marker of endothelial damage in ZCL as related to number and clinical type of lesions.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Universitiy of Ain Shams, Egypt.
authors.forename: T A
authors.initials: TA
authors.lastname: Morsy
authors.forename: A M
authors.initials: AM
authors.lastname: el-Shazly
authors.forename: I M
authors.initials: IM
authors.lastname: Nagaty
authors.forename: A I
authors.initials: AI
authors.lastname: Maboud
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis* / Q000469:parasitology; D008213:Lymphocyte Activation; D008297:Male; D012995:Solubility; D015047:Zoonoses
chemical_list: D015815:Cell Adhesion Molecules