title: Intratumoral hemorrhage from a posterior fossa tumor after cardiac valve surgery--case report.
abstract: A 53-year-old woman suffered intracranial hemorrhage from a cerebellar tumor several days after aortic valve replacement. Surgical intervention was not performed because the patient refused blood infusion for religious reasons (Jehovah's Witness). Instead, the anticoagulation therapy was interrupted for a week, and the patient was conservatively treated with administration of mannitol and steroid. The anticoagulation therapy was restarted 7 days after the hemorrhage. The intratumoral hemorrhage did not recur, and no systemic embolism occurred. The tumor was treated with gamma knife radiosurgery 6 weeks after the hemorrhage, under the radiological diagnosis of meningioma. Anticoagulation therapy is routinely used for patients following cardiac surgery to decrease the risk of thromboembolic complications, but also increases the risk of hemorrhagic events which often involve the central nervous system. Temporary discontinuation of anticoagulation therapy is an option for intratumoral hemorrhage in patients with replacement heart valves, and patients with known brain tumors should be informed about the risk of intracranial hemorrhage before cardiac surgery.
authors.affiliation: Department of Neurosurgery, Suwa Chuou Hospital, Chino, Nagano, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Gotoh
authors.forename: E
authors.initials: E
authors.lastname: Chikui
authors.forename: T
authors.initials: T
authors.lastname: Furusawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D001021:Aortic Valve; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery; D002528:Cerebellar Neoplasms / Q000098:blood supply / Q000150:complications* / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000209:etiology*; D003388:Cranial Fossa, Posterior; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008353:Mannitol / Q000627:therapeutic use; D008577:Meningeal Neoplasms / Q000098:blood supply / Q000150:complications* / Q000601:surgery; D008579:Meningioma / Q000098:blood supply / Q000150:complications* / Q000601:surgery; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000517:prevention & control; D016634:Radiosurgery; D013923:Thromboembolism / Q000517:prevention & control; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000925:Anticoagulants; D008353:Mannitol; D014859:Warfarin; D006493:Heparin