title: [Clinical significance of measurement of urinary leukotriene E4 in asthmatic patients without attack].
abstract: To evaluate clinical significance of measurement of urinary leukotriene E4 (LTE4) in asthmatic patients without attack, we measured urinary LTE4 in 68 asthmatic patients without attack and investigated its correlation with severity of asthma, % FEV1, bronchial hyperresponsiveness and peripheral eosinophil counts. Values of urinary LTE4 were significantly higher in the asthmatic patients (113.6 +/- 9.7 pg/mg.cr) than in healthy control subjects (67.8 +/- 4.7, n = 31), and the level of urinary LTE4 was in proportion to the severity of disease. Urinary LTE4 showed significant negative correlation with % FEV1 in atopic patients (Rs = -0.43, p = 0.025, n = 28), which was not recognized in non-atopic patients. Urinary LTE4 showed no significant correlation with bronchial hyperresponsiveness and peripheral eosinophil counts. Our findings suggested that basal LTE4 in urine reflected chronic airway inflammation of asthma.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawagishi
authors.forename: R
authors.initials: R
authors.lastname: Oosaki
authors.forename: H
authors.initials: H
authors.lastname: Mita
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
authors.forename: N
authors.initials: N
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Kashii
authors.forename: N
authors.initials: N
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
authors.forename: K
authors.initials: K
authors.lastname: Akiyama
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology / Q000652:urine*; D016535:Bronchial Hyperreactivity / Q000652:urine; D005260:Female; D006801:Humans; D017998:Leukotriene D4 / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D017998:Leukotriene D4