title: Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha. II.
abstract: Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabdane-type diterpenoid, compound 7 exhibited a remarkable inhibitory effect on EBV-EA induction, and a significant anti-tumor-promoting effect in the mouse two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanovl-phorbol-13-acetate.
authors.affiliation: Kyoto Pharmaceutical University, Japan. konosima@mb.kyoto-phu.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Konoshima
authors.forename: T
authors.initials: T
authors.lastname: Konishi
authors.forename: M
authors.initials: M
authors.lastname: Takasaki
authors.forename: K
authors.initials: K
authors.lastname: Yamazoe
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor / Q000379:methods / Q000706:statistics & numerical data; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000188:drug therapy; D008517:Phytotherapy / Q000379:methods; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts