[Effect of agroclavine on conditional active and passive avoidance responses in mice].
The effect of agroclavine, a compound belonging to the group of ergot alkaloids, on the active and passive avoidance habit learning and retrieval in mice was studied. It was found that agroclavine violated the retention of both habit types, while changing neither the learning rate nor the retrieval efficacy. The drug effect was retained for three weeks after administration. It was suggested that agroclavine probably disturbs the short- to long-term memory transformation.
Lunin
S M
SM
Laboratory of Chemical Addiction Mechanisms, Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142292 Russia.
Bobkova
N V
NV
Arinbasarov
M U
MU
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D004873:Ergolines / Q000494:pharmacology*; D051379:Mice
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D004873:Ergolines; C004465:agroclavine
Vliianie agroklavina na uslovno-reflektornye reaktsii aktivnogo i passivnogo izbeganiia u mysheĭ.