[The expression of RAR beta mRNA in rat tongue carcinogenesis].
OBJECTIVE
To elucidate the relationship between the expression of nuclear retinoic acid receptor beta (RAR beta) mRNA in oral carcinogenesis and squamous cell aberrant differentiation.


METHODS
A total of 69 rat tongue carcinogenesis specimens induced by 4-nitroquinoline-1-oxide (4NQO) were detected for RAR beta mRNA by in situ hybridization.


RESULTS
With the progress of tongue carcinogenesis and epithelium cell disdifferentiation, the expression of RAR beta mRNA was down-regulated. The positive rate of RAR beta mRNA in normal, hyperplasia, mild-moderate dysplasia, severe dysplasia, in situ carcinoma and squamous cell carcinoma was 100.0%, 87.5%, 75.0%, 72.2%, 45.5% and 18.8%, respectively.


CONCLUSIONS
The down-regulation of RAR beta mRNA may be associated with the epithelium cell aberrant differentiation and may be an important molecular mechanism of oral carcinogenesis.
Liu
X
X
Department of Oral and Maxillofacial Surgery, Suzhou Stomatological Hospital, Suzhou 215005, China.
He
R
R
Chen
W
W
D015112:4-Nitroquinoline-1-oxide; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D004195:Disease Models, Animal; D015536:Down-Regulation; D015363:Quinolones; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D018168:Receptors, Retinoic Acid / Q000096:biosynthesis* / Q000235:genetics; D014062:Tongue Neoplasms / Q000139:chemically induced / Q000378:metabolism*
C120195:4-nitroquinolone-1-oxide; D015363:Quinolones; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; C082925:retinoic acid receptor beta; D015112:4-Nitroquinoline-1-oxide