[The roles of oxygen free radicals and superoxide dismutase in the inflammatory injury in animal oral mucosa].
OBJECTIVE
To study the roles of oxygen free radicals (OFRs) and superoxide dismutase (SOD) in the inflammatory injury in animal oral mucosa.


METHODS
1. The animal model was established in which an acute oral mucosal inflammation was induced by OFRs. Enzyme histological methods and biochemical methods were used respectively to investigate the activities of some important enzymes such as nicotinamide adenine dinucleotide phosphate-diaphorase and the amount of aminohexoses in the lesions; 2. Electron spin resonance and radioimmunoassay were ultilize respectively to study the effects of exogenous SOD on the amount of OFRs and prostaglandin E2(PGE2) in the lesions.


RESULTS
1. The activities of the enzymes in the oral lesions decreased and the amount of aminohexoses increased significantly; 2. Local administrating SOD could reduce the amount of OFRs and PGE2 in the lesions sufficiently.


CONCLUSIONS
OFRs induced the inflammatory lesion by injuring some important enzymes and connective tissues in the oral mucosa. Local administrating SOD could scavenge OFRs and PGE2 in the oral mucosa sufficiently and reduce the degree of OFRs--induced oral mucosal inflammatory injury.
Zhou
H
H
School of Stomatology, West China University of Medical Sciences, Chengdu 610041.
Chen
Q
Q
Li
B
B
D000818:Animals; D006224:Cricetinae; D015237:Dinoprost / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D011863:Radioimmunoassay; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013280:Stomatitis / Q000378:metabolism / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000494:pharmacology*
D017382:Reactive Oxygen Species; D015237:Dinoprost; D013482:Superoxide Dismutase