title: Histiocytic necrotizing lymphadenitis preceding systemic lupus erythematosus.
abstract: Necrotizing histiocytic lymphadenopathy (NHL) is a rarely observed clinical entity that is occasionally associated with systemic lupus erythematosus (SLE). The histological features of the condition have been considered to be indistinguishable from those of lymphadenitis in subjects with SLE, and the clinical symptoms of the two disorders share common features. This report presents the case history of a subject who developed SLE with central nervous system involvement 3 years following onset of Kikuchi's disease (histiocytic necrotizing lymphadenitis). Repeated lymph node biopsies confirmed the diagnosis in relation to the clinical progression. A review of the literature on this topic is also presented.
authors.affiliation: 2nd Department of Internal Medicine, University of Pécs, Medical Faculty, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Komócsi
authors.forename: E
authors.initials: E
authors.lastname: Tóvari
authors.forename: L
authors.initials: L
authors.lastname: Pajor
authors.forename: L
authors.initials: L
authors.lastname: Czirják
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage; D001707:Biopsy, Needle; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide; D001241:Aspirin