[Clinical observation and experimental study on treatment of malignant tumor with bailong tablet].
OBJECTIVE
To observe the clinical efficacy of treating moderate and advanced malignant tumors with the compound Chinese herbal medicine, Bailong tablet (BLT) and to explore its mechanism.


METHODS
Therapeutic effect of BLT in treating 34 cancer patients was analyzed according to the criteria of therapeutic effect for solid tumor, and changes on their living quality and immune function were observed clinically. In the experimental studies, the effect of BLT on human lymphocyte, celiac macrophage of mice and human gastric cancer cells in vitro were observed.


RESULTS
The total remission rate was 11.8%, the remission-stationary rate was 82.3%, the living quality improved and immune function of organism enhanced, the difference between before and after treatment was significant (P < 0.05 or P < 0.01). Experimental study revealed that comparing with the control group, BLT can induce the activated human lymphocyte to kill target cell, promote the proliferation of T-lymphocyte, activate the phagocytosis of celiac macrophage in vitro(P < 0.05 or P < 0.01).


CONCLUSIONS
BLT has definite therapeutic effect for moderate and advanced cancer, its anti-tumor effect was related to a series of cell biologic mechanisms, such as the immune function enhancement, T-lymphocyte proliferation and macrophage activation.
Zhang
X
X
School of Oncology, Beijing Medical University, Beijing (100036).
Wang
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D
Liu
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S
D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008262:Macrophage Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000276:immunology; D013274:Stomach Neoplasms / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013607:Tablets; D014407:Tumor Cells, Cultured
D004365:Drugs, Chinese Herbal; D013607:Tablets