title: Desensitizing efficacy of a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride.
abstract: OBJECTIVE
  To evaluate the relative effectiveness provided by a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride in a silica base (Colgate Sensitive Maximum Strength) for reducing dentin hypersensitivity over an 8-wk period, as compared to that provided by a commercially-available antihypersensitivity dentifrice containing 5.0% potassium nitrate and 0.76% sodium monofluorophosphate in a dicalcium phosphate base (Fresh Mint Sensodyne dentifrice).
  
  
  METHODS
  To qualify for participation in this examiner-blind study, male and female adults from the San Francisco, California area were required to present with tactile and air blast dentin hypersensitivity in at least 2 non-molar teeth at two examinations, spaced 1 wk apart. Qualifying subjects were randomized into two treatment groups, which were balanced for gender, age, and baseline sensitivity scores. Subjects were provided with a soft-bristled toothbrush. Examinations for tactile and air blast sensitivity were repeated after 4 wks' use of the study dentifrices, and again after 8 wks' usage.
  
  
  RESULTS
  101 subjects complied with the protocol, and completed the entire study. After 4 wks, subjects assigned to the Colgate Sensitive Maximum Strength group exhibited a statistically significant improvement over the Fresh Mint Sensodyne dentifrice group with respect to tactile sensitivity scores, and a statistically significant improvement over the Sensodyne dentifrice group with respect to air blast sensitivity scores. Correspondingly significant improvements were presented after 8 wks. Thus, the results of this examiner-blind clinical study support the conclusion that Colgate Sensitive Maximum Strength dentifrice provided superior levels of control of tactile and air blast sensitivity than did the clinically tested, commercially-available Sensodyne anti-hypersensitivity dentifrice.
authors.affiliation: Department of Oral and Maxillofacial Radiology, School of Dentistry, University of the Pacific, San Francisco, California 94115, USA. tschiff@uop.edu
authors.forename: T
authors.initials: T
authors.lastname: Schiff
authors.forename: Y
authors.initials: Y
authors.lastname: Bonta
authors.forename: H M
authors.initials: HM
authors.lastname: Proskin
authors.forename: W
authors.initials: W
authors.lastname: DeVizio
authors.forename: M
authors.initials: M
authors.lastname: Petrone
authors.forename: A R
authors.initials: AR
authors.lastname: Volpe
mesh_terms: D000328:Adult; D000368:Aged; D000388:Air; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D045424:Complex Mixtures; D003802:Dentifrices / Q000494:pharmacology* / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000503:physiopathology / Q000517:prevention & control*; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage / Q000627:therapeutic use*; D014677:Pharmaceutical Vehicles; D010710:Phosphates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D012822:Silicon Dioxide; D016037:Single-Blind Method; D013223:Statistics as Topic; D014002:Tin Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D014099:Toothbrushing / Q000295:instrumentation; D014110:Touch / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D002327:Cariostatic Agents; D045424:Complex Mixtures; D003802:Dentifrices; D004338:Drug Combinations; D009566:Nitrates; D014677:Pharmaceutical Vehicles; D010710:Phosphates; D017680:Potassium Compounds; C097427:Sensodyne; D014002:Tin Fluorides; C444700:colgate sensitive; D012822:Silicon Dioxide; D005459:Fluorides; C023844:potassium nitrate