Expression of the prothymosin-a gene as a prognostic factor in lung cancer.
Prothymosin-alpha (PTalpha) is known to play a role in cell proliferation, and the PTalpha mRNA level may reflect the degree of proliferation of tumor cells. It has been reported that PTalpha mRNA levels are higher in human colon and liver cancer tissues than in the adjacent normal tissues. We examined the mRNA levels of PTalpha and c-myc in 20 lung cancers, using Bas 2500Mac systems. The PTalpha and c-myc mRNA levels in lung cancer tissues were higher than those in normal lung tissues; however, the PTalpha mRNA levels did not correlate with the stage or pathological subtype of the lung cancer and there was no correlation between the expression of PTalpha and c-myc. PTalpha mRNA overexpression in lung cancer was correlated with a poor prognosis.
Sasaki
H
H
Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan.
Nonaka
M
M
Fujii
Y
Y
Yamakawa
Y
Y
Fukai
I
I
Kiriyama
M
M
Sasaki
M
M
D000368:Aged; D020869:Gene Expression Profiling; D016259:Genes, myc; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D011498:Protein Precursors / Q000032:analysis / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013947:Thymosin / Q000031:analogs & derivatives* / Q000032:analysis / Q000235:genetics*
D011498:Protein Precursors; D012333:RNA, Messenger; C040782:prothymosin alpha; D013947:Thymosin