title: [Immunotherapy by B-lymphocytes in patients with unexplained habitual abortion].
abstract: OBJECTIVE
  To investigate the safety and efficacy of immunotherapy in patients with unexplained habitual abortion(UHA) with increased human leukocyte antigen (HLA) mutual antigen.
  
  
  METHODS
  Twenty-four UHA women were immunized by their husband's B-lymphocytes for 3 months.
  
  
  RESULTS
  Twenty-two of them had increased HLA mutual antigen. The their anti-paternal lymphocytotoxic antitody (APCA) positive rate was 8% before immunization, significantly lower than that of the control group (86%). After immunization, the APCA positive rate increased significantly to 75%, 20 cases achieved pregnancy and 16 deliverd normal newborns.
  
  
  CONCLUSIONS
  Immunotherapy by husband's B-lymphocytes is effective in UHA with increased HLA mutual antigen, and may have less adverse effect.
authors.affiliation: Dongshan District People's Hospital, Guangzhou 510080, China.
authors.forename: G
authors.initials: G
authors.lastname: Zhu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: B
authors.initials: B
authors.lastname: Ning
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology / Q000628:therapy*; D000328:Adult; D000961:Antilymphocyte Serum / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007167:Immunotherapy; D011247:Pregnancy
chemical_list: D000961:Antilymphocyte Serum