title: Antibacterial activity of fifth-generation dentin bonding systems.
abstract: Past concepts that the pulp does not become infected until an actual carious exposure takes place have been challenged. The antibacterial effects of the dentin bonding systems Single Bond, Prime&Bond NT, and Excite were evaluated using the bacteria Streptococcus mutans ATCC 25175, Streptococcus intermedius, Lactobacillus acidophilus, Prevotella oris, Prevotella bivia, Prevotella denticola, Porphyromonas gingivalis, Porphyromonas endodontalis, and Clostridium ramosum with a disk diffusion method. Chlorhexidine (0.2%) was used as a positive control. After incubation zones of inhibited bacterial growth were measured. Prime&Bond NT showed growth inhibition for all bacterial strains. Lactobacillus acidophilus and Streptococcus mutans were remarkably resistant to Single Bond, whereas EX produced no inhibitory effect on Porphyromonas endodontalis, although the adhesive produced the maximum halo inhibition to Streptococcus mutans (15+/-1 mm), showing an antibacterial effect closest to chlorhexidine. The variety of results obtained in this study suggest that antibacterial properties of current dentin adhesives may depend on components that are originally incorporated to promote adhesion.
authors.affiliation: Department of Pediatric Dentistry, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
authors.forename: A S
authors.initials: AS
authors.lastname: Atac
authors.forename: Z C
authors.initials: ZC
authors.lastname: Cehreli
authors.forename: B
authors.initials: B
authors.lastname: Sener
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D017438:Bisphenol A-Glycidyl Methacrylate / Q000494:pharmacology; D017220:Dentin-Bonding Agents / Q000494:pharmacology*; D008689:Methacrylates / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011109:Polymethacrylic Acids / Q000494:pharmacology; D018709:Statistics, Nonparametric
chemical_list: D000891:Anti-Infective Agents, Local; D017220:Dentin-Bonding Agents; C420130:Excite cement; D008689:Methacrylates; D011109:Polymethacrylic Acids; C425843:Prime and Bond NT; C115612:single bond; D017438:Bisphenol A-Glycidyl Methacrylate