[Effect of -6 degrees head-down-bed-rest on human cellular immune function].
OBJECTIVE
To observe the effect of -6 degrees head-down bed-rest on proliferation of lymphocyte and production of certain cytokines.


METHODS
6 healthy young men served as the subjects. Peripheral blood lymphocyte was assayed 1d prior to and on the 3rd day and 6th day of bed rest.


RESULTS
The production of IFN-alpha on the 3rd day was markedly decreased (P < 0.05), but killing activity of NK was significantly enhanced (P < 0.05), production of IFN-gamma and expression of IL-2 receptor were all slightly reduced. Both production of IFN-alpha and killing activity of NK resumed to the control level on the 6th day, production of IFN-r and CD25 were significantly lowered (P < 0.05) on the 6th day, a lymphocyte proliferation and production of IL-2 were gradually decreased with time, but production of IL-6 was gradually increased.


CONCLUSIONS
-6 degrees head-down bed-rested has certain effect on cellular immune function in man.
Wen
X L
XL
Institute of Space Medico-Engineering, Beijing, China.
Hu
P
P
Yang
G H
GH
Si
S Y
SY
Duan
Y R
YR
D000328:Adult; D001510:Bed Rest; D016207:Cytokines / Q000276:immunology*; D018475:Head-Down Tilt; D006801:Humans; D007111:Immunity, Cellular; D016898:Interferon-alpha / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology; D015850:Interleukin-6 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D018474:Weightlessness Simulation
D016207:Cytokines; D016898:Interferon-alpha; D007376:Interleukin-2; D015850:Interleukin-6