[Prognostic significance of local and systemic indicators of lipid peroxidation and antioxidant system in perforating wounds of the eyes and their time course during local antioxidant treatment].
Lipid peroxidation parameters malonic dialdehyde (MDA) and dienic conjugates (DC) and antioxidant defense (AOD) values superoxide dismutase (SOD), catalase, alpha-tocopherol were measured in the blood neutrophils and lacrimal fluid of 66 patients on days 1-2, 7-8, 14-15, and 21-22 after perforating wound of first, second, third, and fourth degree of severity according to P, 1. Lebekhov and in repeated injury, and the time course of these parameters during local treatment with therapeutic films with emoxipin and emoxipin + piridoxine was evaluated. A stable increase of MDA and DC levels in blood neutrophils, decrease of catalase, SOD, and alpha-tocopherol levels in blood neutrophils, and decrease of catalase enzymes and SOD activities in the lacrimal fluid of injured eye starting from days 7-8 are prognostically unfavorable signs. These data prompt the use of local and systemic treatment with antioxidants (emoxipin, tocopherol, etc.) in perforating wounds starting from the first days after the injury. Good clinical and antioxidant effect was observed after treatment with ocular therapeutic films with emoxipin and piridoxine.
Arkhipova
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Dolgova
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D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002374:Catalase / Q000032:analysis / Q000097:blood; D004359:Drug Therapy, Combination; D015807:Eye Injuries, Penetrating / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000097:blood; D008875:Middle Aged; D009504:Neutrophils / Q000737:chemistry; D010847:Picolines / Q000008:administration & dosage / Q000627:therapeutic use*; D011379:Prognosis; D011736:Pyridoxine / Q000008:administration & dosage / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000032:analysis / Q000097:blood; D013666:Tears / Q000737:chemistry; D013997:Time Factors; D024505:Tocopherols / Q000032:analysis / Q000097:blood
D000975:Antioxidants; D010847:Picolines; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D011736:Pyridoxine; D024505:Tocopherols; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Prognosticheskaia znachimost' mestnykh i sistemnykh pokazateleĭ perekisnogo okisleniia lipidov i antioksidantnoĭ sistemy pri pronikaiushchikh raneniiakh glaz i ikh dinamika na fone mestnogo primeneniia antioksidantov.