A highly enantioselective intramolecular Heck reaction with a monodentate ligand.
An efficient enantioselective intramolecular Heck reaction of cyclohexadienones, using readily available and modular TADDOL-based mono- and bidentate phosphoramidites as chiral ligands and not requiring any additives, has been developed. Excellent enantioselectivities up to 96% ee are reached for the first time in a Heck reaction with monodentate ligands.
Imbos
Rosalinde
R
Stratingh Institute, Department of Organic Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Minnaard
Adriaan J
AJ
Feringa
Ben L
BL
D001685:Biological Factors / Q000138:chemical synthesis; D003510:Cyclohexanes / Q000737:chemistry*; D053138:Cyclohexenes; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D001685:Biological Factors; D003510:Cyclohexanes; D053138:Cyclohexenes; D009943:Organophosphorus Compounds; C434331:phosphoramidite; C048401:1,4-cyclohexadiene