title: [Aerosolized iloprost therapy in an infant with chronic pulmonary hypertension after a neonatal arterial switch operation].
abstract: The treatment of chronic pulmonary hypertension with prostacyclin in children is prone to severe complications due to mandatory long-term venous therapy. Inhaled iloprost has been evaluated in adult patients with good preliminary results.
  
  
  METHODS
  We report our experience of the use of aerosolized iloprost in an infant treated for pulmonary hypertension associated to a right ventricular failure, which occurred after a neonatal arterial switch operation for transposition of the great arteries. For nine months, hemodynamic and functional status improved and the quality of life was satisfactory at home.
  
  
  CONCLUSIONS
  If further experiences and studies support this observation, aerosolized iloprost could be an alternative to prostacyclin venous therapy in treating children with chronic pulmonary hypertension.
authors.affiliation: Centre chirurgical Marie-Lannelongue, 133, avenue de la Résistance, 92350 Le-Plessis-Robinson, France. vlambert@ccml.com
authors.forename: V
authors.initials: V
authors.lastname: Lambert
authors.forename: A
authors.initials: A
authors.lastname: Serraf
authors.forename: P
authors.initials: P
authors.lastname: Durand
authors.forename: J
authors.initials: J
authors.lastname: Losay
mesh_terms: D000280:Administration, Inhalation; D013504:Cardiovascular Surgical Procedures / Q000009:adverse effects*; D002908:Chronic Disease; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology*; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology*; D007231:Infant, Newborn; D008297:Male; D014188:Transposition of Great Vessels / Q000601:surgery*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D016285:Iloprost
vernacular_title: Traitement par iloprost en aérosol d'un nourrisson atteint d'hypertension artérielle pulmonaire chronique après cure chirurgicale néonatale d'une transposition des gros vaisseaux.