Timing treatment to the rhythm of disease. A short course in chronotherapeutics.
The recognition of circadian rhythms in both normal human biologic function and disease has heightened the awareness that the timing of drug regimens may have an important impact on effectiveness of treatment. Outcomes in several diseases that have predictable circadian variations (e.g., arthritis, asthma, allergies, pepticulcer disease, dyslipidemia, cancer) have been improved by matching the timing of medication use to the circadian rhythm of the illness. Results of the ongoing CONVINCE study may provide evidence that chronotherapy for hypertension and angina pectoris may be more effective than traditional homeostatic treatment.
Elliott
W J
WJ
Rush Medical College, Rush University, Chicago, USA. welliott@rush.edu
D000970:Antineoplastic Agents / Q000008:administration & dosage; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000503:physiopathology; D019454:Chronotherapy; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000503:physiopathology; D014700:Verapamil / Q000008:administration & dosage
D000970:Antineoplastic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014700:Verapamil