Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis.
We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.
Sørensen
Torben L
TL
The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, 2600 Glostrup, Denmark. torbenls@dadlnet.dk
Roed
Hanne
H
Sellebjerg
Finn
F
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000328:Adult; D001402:B-Lymphocytes / Q000378:metabolism*; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000276:immunology; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016899:Interferon-beta / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000188:drug therapy* / Q000276:immunology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000276:immunology; D019713:Receptors, CCR5 / Q000096:biosynthesis; D054367:Receptors, CXCR3; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine / Q000096:biosynthesis*; D018121:Receptors, Cytokine / Q000096:biosynthesis
D000276:Adjuvants, Immunologic; C515187:CXCR3 protein, human; C095085:CXCR5 protein, human; D019713:Receptors, CCR5; D054367:Receptors, CXCR3; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D016899:Interferon-beta