Mathematical models of radiation-induced mitotic delay: time course analysis and statistics of lesions.
Detailed investigations of high and low LET radiation induced chromosome aberrations in various mammalian cell lines have shown that the registered yield of aberrations depends on cell cycle progression delays. The effect of radiation on the cell kinetics can be analyzed in terms of kinetic growth models. The method yields the number of aberrant cells and the number of aberrations as totals obtained after integration over given time-interval.
Gudowska-Nowak
E
E
Marian Smoluchowski Institute of Physics, Jagellonian University, Krakow, Poland.
Kleczkowski
A
A
Kraft
G
G
Nasonova
E
E
Ritter
S
S
Scholz
M
M
D000818:Animals; D001128:Argon; D002453:Cell Cycle / Q000528:radiation effects; D002478:Cells, Cultured / Q000528:radiation effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D007477:Ions; D007700:Kinetics; D018499:Linear Energy Transfer; D008938:Mitosis / Q000528:radiation effects*; D008954:Models, Biological; D012062:Relative Biological Effectiveness; D013997:Time Factors
D007477:Ions; D001128:Argon