[Changes in the afferent activity of the vagus nerve and the rectal temperature in rats following Escherichia coli endotoxin administration].
In anaesthetised rats, i.p. administration of the Echerichia coli lipopolysaccharide in doses 5 mcg/kg (LPS) increased afferent activity of the cervical vagus, whereas 100 and 1000 mcg/kg doses inhibited the afferent discharges. Pyrogen-free saline (PFS) did not alter the activity. Rectal temperature (RT) was decreased by the PFS and by large doses of the LPS. Sodium salicylate administration prevented the effects.
Lapsha
V I
VI
Institute of Physiology, National Acad. Sci., Minsk, 220072, Akademicheskaya St., 28, Belarus.
Lukashenko
T M
TM
Utkina
L N
LN
Gurin
V N
VN
D000344:Afferent Pathways / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects*; D004926:Escherichia coli; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D015213:Neuroimmunomodulation; D051381:Rats; D017208:Rats, Wistar; D012980:Sodium Salicylate / Q000494:pharmacology; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; C440499:lipopolysaccharide, Escherichia coli O111 B4; D012980:Sodium Salicylate
Izmeneniia afferentnoĭ impul'satsii v bluzhdaiushchikh nervakh i rektal'noĭ temperatury u krys posle vvedeniia éndotoksina Escherichia coli.