title: [Interaction of heparin with amino group-containing materials].
abstract: The influence of the glass surface immobilized aminogroups nature and the experiments conditions on the interactions between heparin and aminogroups containing surface was studied using total internal reflections fluorescence. It was shown, that the nature of the terminating aminogroup, but not its mobility or the amount of the aminogroups in the main chain, is the major factor influencing the heparin adsorbtion from individual solution. Both the nature of terminating aminogroup and its mobility determine heparin adsorption on the aminogroups containing surfaces from the blood plasma proteins containing solution. Heparin irreversibly adsorbed from individual solution is not replaced by blood plasma proteins. The tertiary aminogroups containing surface adsorbs maximal quantity of the heparin.
authors.affiliation: Institute of Transplantology and Artificial Organs, Moskow.
authors.forename: E A
authors.initials: EA
authors.lastname: Nemets
authors.forename: D A
authors.initials: DA
authors.lastname: Kasatov
authors.forename: V I
authors.initials: VI
authors.lastname: Sevast'ianov
mesh_terms: D000327:Adsorption; D000588:Amines / Q000737:chemistry*; D000925:Anticoagulants / Q000737:chemistry*; D001798:Blood Proteins / Q000737:chemistry; D005898:Glass; D006493:Heparin / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D008422:Materials Testing; D009994:Osmolar Concentration; D012996:Solutions
chemical_list: D000588:Amines; D000925:Anticoagulants; D001798:Blood Proteins; D012996:Solutions; D006493:Heparin
vernacular_title: Vzaimodeĭstvie geparina s aminosoderzhashchimi materialami.