title: Effect of hyperthermia on AKR lymphoma variants differing in degree of malignancy.
abstract: The effect of hyperthermic treatment on AKR lymphoma cells of varying malignancy was investigated. Tumor cells were pretreated at 37 or 43 degrees C and then injected to mice. The effect on the highly malignant variant, TAU-38, was compared to that on the low-malignancy variant, TAU-39, following both subcutaneous (s.c.) and intravenous (i.v.) inoculation. Hyperthermia showed no effect on the TAU-39 variant following s.c. inoculation on the primary tumors or mice survival, but the TAU-38 variant exhibited a significant delay of tumor appearance following treatment, namely, decreased tumor size and increased life span. Following i.v. inoculation, in both variants, hyperthermia caused a significant decrease in metastatic spread and an increased life span. We conclude that hyperthermia, in addition to exerting a greater effect on the high-malignancy variant, acts at the late phases of metastasis. Hyperthermia might therefore have a place in the management of cancer in its advanced disseminated phase.
authors.affiliation: Department of Internal Medicine D, The Chaim Sheba Medical Center, Tel Hashomer, Israel. yina@internet-zahav.net
authors.forename: Y
authors.initials: Y
authors.lastname: Sharabi
authors.forename: G
authors.initials: G
authors.lastname: Klorin
authors.forename: J
authors.initials: J
authors.lastname: Leibovici
mesh_terms: D000818:Animals; D006979:Hyperthermia, Induced; D008223:Lymphoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008806:Mice, Inbred AKR; D015996:Survival Rate