CA 125: the end of the beginning.
CA 125, a high-molecular-weight mucin, was first defined in 1981 by the monoclonal antibody OC125. Until recently, it has defied many attempts to purify it from a variety of sources, although many research groups have successfully raised antibodies that bind to CA 125. Nevertheless, CA 125 has demonstrated its considerable value as a marker in monitoring patients with ovarian cancer. This year, two research groups have succeeded in cloning the high-molecular-weight mucin CA 125. Their findings are summarized and the significance discussed in light of existing data from the human genome.
Hovig
E
E
Central Laboratory, Norwegian Radium Hospital, Oslo, Norway.
Rye
P D
PD
Warren
D J
DJ
Nustad
K
K
D018394:CA-125 Antigen / Q000096:biosynthesis / Q000235:genetics*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003001:Cloning, Molecular; D005260:Female; D006801:Humans; D009077:Mucins / Q000096:biosynthesis / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism
D018394:CA-125 Antigen; D009077:Mucins