[Experimental study on effect of bushen yijing recipe in delaying senility of bone and brain of aged male rats].
OBJECTIVE
To evaluate the effect of Bushen Yijing recipe (BSYJR) in delaying senility of bone and brain of aged male rats and infer its mechanism in delaying systemic senility.


METHODS
Forty male SD rats, 24 months old were randomly divided into 4 groups, the baseline control group, the aged control group (30 months old), the BSYJR high dose group and the BSYJR low dose group. The latter two groups received BSYJR treatment from 24 months old to 30 months old. Bone indexes (bone density of the proximal, middle and distal segments of left femur and break bending load of right femur) and brain indexes (binding capacity of M receptor and cholinesterase activity of brain) were measured after responding treatment.


RESULTS
In bone, BSYJR could not only increase the bone mineral density in various segments of femur, but also raise the bending break load of femur dose-effect dependently. In brain, BSYJR could both up-regulate the binding capacity of M receptor and inhibit the activity of cholinesterase.


CONCLUSIONS
BSYJR could delay the senility of bone and brain in male rats, inferring that it might regulate integrally the abnormality of aging in Kidney Asthenia and Essence Deficiency through mediation of nerve-endocrine-immunity network.
Zhang
G
G
Institute of Orthopedics and Traumatology, Shanghai Academy of TMC, Shanghai (200032).
Ma
J
J
Zhang
Q
Q
D000375:Aging / Q000187:drug effects*; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D002802:Cholinesterases / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D011976:Receptors, Muscarinic; D002802:Cholinesterases