192Ir endovascular irradiation prevents restenosis after balloon angioplasty in rabbit.
OBJECTIVE
To examine the effect of endovascular irradiation on restenosis after balloon angioplasty in rabbit.


METHODS
After the establishment of rabbit iliac atherosclerosis model, balloon angioplasty was performed at the lesion segment of the iliac artery. Rabbits were randomly divided into three groups: control group, 10 Gy irradiated group and 18 Gy irradiated group. Endovascular irradiation was performed for irradiated groups at the dilated sites by introducing the 192Ir radioactive guidewire through a catheter. After four weeks, the animals were killed and the target segments were cut down. Histopathologic and morphometric analyses were carried out.


RESULTS
The mean final lumen area in the 18 Gy group was larger than that in the control or 10 Gy group (P < 0.05). The intimal area in the 18 Gy group was smaller (P < 0.05).


CONCLUSIONS
192Ir endovascular irradiation may prevent restenosis after balloon angioplasty. The effect is related to the delivered dose. The mechanism is involved in inhibition of neointimal proliferation.
Chen
M
M
Department of Cardiology, Peking University First Hospital, Beijing 100034, China.
Huo
Y
Y
Liu
Z
Z
Wang
R
R
Zhu
G
G
D000800:Angioplasty, Balloon; D000818:Animals; D001918:Brachytherapy; D023903:Coronary Restenosis / Q000517:prevention & control*; D007083:Iliac Artery / Q000473:pathology; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D011817:Rabbits
D007496:Iridium Radioisotopes