August 2001: Sellar/suprasellar mass in a 59-year-old woman.
The August 2001 COM. Symptomatic granular cell tumors (GCTs) of the neurohypophysis are rare lesions. They are generally regarded as benign neoplasms, although detailed descriptions of the natural course of the tumors are limited to a few cases. We report on a 59-year-old woman with a large GCT of the neurohypophysis and rapid onset of symptoms. Although lacking definitive signs of malignancy, the tumor showed nuclear polymorphism, proliferative activity, evidence of a mutation of the tumor suppressor gene p53 as well as expression of the apoptosis-inhibiting protein bcl-2. These indices may be useful in defining more precisely the clinicopathological prognosis for neurohypophyseal GCTs.
Vogelgesang
Silke
S
Department of Neuropathology, University of Greifswald, Germany.
Junge
Michael H
MH
Pahnke
Jens
J
Gaab
Michael R
MR
Warzok
Rolf W
RW
D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D016586:Granular Cell Tumor / Q000473:pathology* / Q000503:physiopathology; D006261:Headache / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000503:physiopathology; D009897:Optic Chiasm / Q000473:pathology* / Q000503:physiopathology; D019574:Optic Nerve Neoplasms / Q000556:secondary*; D010900:Pituitary Diseases / Q000473:pathology* / Q000503:physiopathology; D010904:Pituitary Gland, Posterior / Q000473:pathology* / Q000503:physiopathology / Q000648:ultrastructure; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000503:physiopathology; D012658:Sella Turcica / Q000473:pathology*; D016896:Treatment Outcome; D015354:Vision, Low / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D014839:Vomiting / Q000209:etiology / Q000473:pathology / Q000503:physiopathology
D014408:Biomarkers, Tumor