[A study of the effects of basic fibroblast growth factor on fibrovascular ingrowth into hydroxyapatite orbital implants].
OBJECTIVE
To investigate the effects of different doses of basic fibroblast growth factor (bFGF) on the fibrovascular ingrowth into hydroxyapatite orbital implants.


METHODS
Thirty-six New Zealand albino rabbits were divided into 4 groups, and hydroxyapatite orbital spheres were implanted into their orbits. The implants were pretreated with 0.5, 1.5 and 5.0 g/L bFGF solution respectively in 3 groups, the untreated implants were used in the control group. At the postoperative 2, 4 and 6 weeks the implants were harvested. Observers classified the extent of the fibrovascular ingrowth in a blind manner under light microscopy.


RESULTS
Histologic studies demonstrated that postoperatively, the rate of vascularization of the implants pretreated with 1.5 and 5.0 g/L bFGF solution was significantly increased at week 2 in comparison with that of the control group. No difference was noted between the group with the implants pretreated with 0.5 g/L bFGF solution and the control group.


CONCLUSIONS
The bFGF 1.5 and 5.0 g/L in concentration may promote the fibrovascular ingrowth into hydroxyapatite orbital implants at week 2 after the implantation.
Huang
D
D
Zhongzhan Opthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
Liu
J
J
Li
Y
Y
D000818:Animals; D004305:Dose-Response Relationship, Drug; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006882:Hydroxyapatites; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D020273:Orbital Implants; D011817:Rabbits
D006882:Hydroxyapatites; D016222:Fibroblast Growth Factor 2