title: Evolution of the need for operation for peptic pyloric stenosis over a period of 24 years (1976-1999).
abstract: OBJECTIVE
  To analyse the need for operation for pyloric stenosis caused by duodenal ulcer over a period of 24 years (1976-1999).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  University hospital, Spain.
  
  
  METHODS
  156 patients operated on for peptic pyloric stenosis.
  
  
  METHODS
  The number of patients operated on yearly were grouped into 4-year periods for statistical comparison.
  
  
  RESULTS
  The number of cases operated on each year steadily decreased between 1976 and 1999. In the 1988-1991 period there was a significant reduction (p <0.05), which continued over the next two 4-year periods, particularly the last (p <0.01).
  
  
  CONCLUSIONS
  Although we cannot use this study to establish a direct relation between the decrease in the indication for operations for peptic pyloric stenosis and the use of H2 antagonists, proton pump inhibitors, or treatment to eradicate Helicobacter pylori, we did find a significance difference between the years before and after the introduction of these drugs.
authors.affiliation: Department of General Surgery and Digestive I. Virgen de la Arrixaca University Hospital, Murcia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Piñero Madrona
authors.forename: R
authors.initials: R
authors.lastname: Robles
authors.forename: J
authors.initials: J
authors.lastname: López
authors.forename: M
authors.initials: M
authors.lastname: Montoya
authors.forename: J L
authors.initials: JL
authors.lastname: Aguayo
authors.forename: F
authors.initials: F
authors.lastname: Sánchez-Bueno
authors.forename: P
authors.initials: P
authors.lastname: Parrilla
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D013505:Digestive System Surgical Procedures / Q000706:statistics & numerical data*; D004381:Duodenal Ulcer / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D017558:Elective Surgical Procedures / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011707:Pyloric Stenosis / Q000209:etiology* / Q000601:surgery*; D012189:Retrospective Studies; D018570:Risk Assessment; D013030:Spain
chemical_list: D000897:Anti-Ulcer Agents