The role of cellular migration in the repair process of gastric epithelial cells.
The epithelial cells of stomach are continuously exposed to various toxic agents that may cause mucosal injury. The epithelial lining is rapidly replaced by cells that migrate from the proliferative zone of the gastric gland, to maintain the integrity of the gastric mucosa. Thus, cell migration is an essential part of the early process of gastric mucosal repair. After various forms of gastric injury, mucosal integrity is reestablished by the rapid migration of epithelial cells. However, the cellular mechanisms of the restitution remain unclear to date. In this report, we will review the role of cellular migration in the repair process of gastric epithelial cells in culture. It has been reported that hepatocyte growth factor (HGF) has the potency of acceleration of cellular repair process. In this review, we also report that HGF plays a leading role in the mucosal repair after damage by using a novel cell culture model.
Terano
A
A
Department of Gastroenterology, Dokkyo University School of Medicine, Tochigi, Japan.
Sakata-Horie
K
K
Shimada
T
T
Hiraishi
H
H
Yoshiura
K
K
Yoneda
M
M
Takahashi
M
M
Fujimori
T
T
D000818:Animals; D015152:Blotting, Northern; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D017228:Hepatocyte Growth Factor / Q000494:pharmacology / Q000502:physiology*; D009578:Nitrobenzenes / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013449:Sulfonamides / Q000494:pharmacology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
D016861:Cyclooxygenase Inhibitors; D009578:Nitrobenzenes; D013449:Sulfonamides; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; D017228:Hepatocyte Growth Factor