[T4336C variant--a marker of mitochondrial subgroup H1, a common component of the Russian and German gene pool].
Analysis of mitochondrial DNA (mtDNA) restriction polymorphism carried out in a sample of Russians from Magadan (n = 150) showed that the frequency of the +4332AvaII variant (a T-C transition at nucleotide position 4336) in this population was 4.7%. All +4332AvaII types of mtDNA belonged to the mitochondrial group H. They were characterized by a back of the AluI restriction endonuclease site at position 7025. According to hypervariable segment 1 sequencing data, they contained the 16304C variant, and thus belong to the subgroup H1. Thus, the +4332AvaII (T4336C) variant is a marker of the mitochondrial subgroup H1, chiefly occurring in German-speaking populations. Utilization of the H1-mtDNA markers for the investigation of the genetic history and the origin of Slavs is discussed.
Maliarchuk
B A
BA
Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, 685000 Russia.
Derenko
M V
MV
D004272:DNA, Mitochondrial / Q000235:genetics*; D005788:Gene Pool; D005819:Genetic Markers; D005858:Germany; D006239:Haplotypes; D006801:Humans; D012426:Russia
D004272:DNA, Mitochondrial; D005819:Genetic Markers
Variant T4336C--marker mitokhondrial'noĭ subgaplogruppy H1, obshchego komponenta genofondov Russkikh i Germantsev.