[Effect of sijunzi decoction on serum soluble intercellular adhesive molecule-1, interleukin-15 and monocyte antibody-dependent cell-mediated cytotoxicity in patients of spleen-deficiency].
OBJECTIVE
To study the effect of Sijunzi Decoction (SJZD) on serum soluble intercellular adhesive molecule-1 (sICAM-1), interleukin-15 (IL-15) and monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) in patients of Spleen-Deficiency.


METHODS
Serum sICAM-1, IL-15 and monocyte ADCC of 66 Spleen-Deficiency patients were determined by enzyme-linked immunosorbent assay and modified thiazole blue test.


RESULTS
Serum sICAM-1 of Spleen-Deficiency patients increased, IL-15 secretion decreased and monocyte ADCC function reduced, which displayed as lowered immune function. After SJZD treatment, all the above-mentioned parameters were normalized.


CONCLUSIONS
SJZD could enhance immune function of organism by strengthening Spleen and tonifying Qi.
Zhang
M
M
Department of TCM, Xijing Hospital, Fourth Military Medical University, Xi'an (710032).
Zhang
Z
Z
Xia
T
T
D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity; D004311:Double-Blind Method; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D019409:Interleukin-15 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D016711:Yang Deficiency / Q000188:drug therapy*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D019409:Interleukin-15; D018799:Intercellular Adhesion Molecule-1