Adenosine deaminase activity in the gastric mucosa of duodenal ulcer patients in relation to the severity of chronic gastritis and gastric acid secretion.
Earlier reports suggested that adenosine deaminase activity in the gastric corpus mucosa depends upon either gastric acid secretion or severity of chronic gastritis. Knowing that gastric acid secretion corresponds well with histological status of the gastric mucosa, the aim of this study was to determine the enzyme activity in relation to these two factors evaluated simultaneously. The study was conducted on Helicobacter pylori positive duodenal ulcer patients treated for two weeks with either omeprazole alone or omeprazole in combination with amoxycillin and tinidazole. It was found that these two therapeutic regimens decreased adenosine deaminase activity only in the gastric corpus mucosa and a decline was more deeper in patients on omeprazole monotherapy. Moreover, omeprazole monotherapy inhibited completely basal gastric acid secretion and did not change the severity of chronic gastritis, while omeprazole-based eradication therapy decreased both the gastric acid secretion and severity of chronic gastritis. One month after completion of eradication therapy adenosine deaminase activity returned to the pretreatment values but severity of chronic gastritis decreased further. The results of the present study indicate that adenosine deaminase activity in the gastric corpus mucosa depends primarily upon gastric acid secretion but not upon the severity of Helicobacter pylori associated chronic gastritis.
Namiot
Z
Z
Department of Medicine & Gastroenterology, J. Sniadecki District Hospital, Department of Physiology, Medical Academy of Białystok, Białystok, Poland.
Namiot
A
A
Kemona
A
A
Stasiewicz
J
J
Górski
J
J
D000243:Adenosine Deaminase / Q000378:metabolism*; D000328:Adult; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000201:enzymology; D005756:Gastritis / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D016481:Helicobacter Infections / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged
D000243:Adenosine Deaminase