[Antipsychotic drugs can affect hormone balance. Weight gain, blood lipid disturbances and diabetes are important].
Hormonally related side effects of antipsychotic drugs, e.g. weight gain, hyperlipidemia and diabetes have come to the forefront in that the use of clozapine and new antipsychotics have increased. Hormones involved are prolactin, growth hormone (GH), insulin-like growth factor I (IGF-I), insulin and leptin. Patients treated with clozapine had lower levels of GH-dependent IGF-I than patients receiving classical antipsychotics. Patients treated with olanzapine had higher serum insulin levels than those receiving classical antipsychotics, indicating a probable influence of olanzapine on insulin secretion. In clozapine-treated patients the insulin levels correlated to the clozapine serum concentration, indicating a likely influence also of clozapine on insulin secretion. The gender difference, i.e. that women normally have higher leptin levels than men, was found in patients receiving classical antipsychotics, but not in patients treated with clozapine or olanzapine.
Melkersson
K
K
Sollentuna sjukhus, Sollentuna. Kristina.Melkersson@knv.ki.se
Hulting
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AL
D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects; D003920:Diabetes Mellitus / Q000139:chemically induced*; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D006966:Hyperprolactinemia / Q000139:chemically induced; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008055:Lipids / Q000097:blood*; D008297:Male; D011388:Prolactin / Q000097:blood; D015430:Weight Gain / Q000187:drug effects*
D014150:Antipsychotic Agents; D007328:Insulin; D008055:Lipids; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D003024:Clozapine
Antipsykotika kan påverka hormonbalansen. Viktökning, blodlipidrubbningar och diabetes viktiga biverkningar.