Antibiotic-resistant cell-detaching Escherichia coli strains from Nigerian children.
The properties of 23 cell-detaching Escherichia coli strains that were isolated from stool specimens in Nigeria are described. Common properties of the strains included the presence of genes encoding alpha-hemolysin (100%), pyelonephritis-associated pili (100%), and cytotoxic necrotizing factor 1 (70%) as well as lactose negativity (70%) and multiple antibiotic resistance (74%). Antibiotic resistance was shown in most cases to be transferable and associated with the presence of class 1 integrons. Phenotypic properties and pulsed-field gel electrophoresis analysis demonstrated that the majority of the strains, particularly multiply resistant, lactose-negative O4:H40 strains, were closely related. Multiply-resistant cell-detaching E. coli strains may represent an important reservoir for antibiotic resistance genes.
Okeke
Iruka N
IN
Department of Microbiology and Immunology and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Steinrück
Hartmut
H
Kanack
Kristen J
KJ
Elliott
Simon J
SJ
Sundström
Lars
L
Kaper
James B
JB
Lamikanra
Adebayo
A
D015373:Bacterial Typing Techniques; D002448:Cell Adhesion; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000235:genetics; D005243:Feces / Q000382:microbiology; D006801:Humans; D009549:Nigeria; D014774:Virulence / Q000235:genetics
D029968:Escherichia coli Proteins