Evaluation of interaction between valproate and baclofen in the formalin test in mice.
Valproate and baclofen dose-dependently inhibited both phases of the formalin test. Combination of valproate and baclofen exerted the additive antinociceptive effect on both phases of the formalin test.
Czuczwar
M
M
Second University Department of Anaesthesiology and Intensive Therapy, Medical University, Lublin, Poland.
Kiś
J
J
Swiader
M
M
Turski
W A
WA
Przesmycki
K
K
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D018682:GABA Agents / Q000494:pharmacology; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects*; D017288:Pain Threshold / Q000187:drug effects*; D014635:Valproic Acid / Q000494:pharmacology*
D018682:GABA Agents; D014635:Valproic Acid; D001418:Baclofen