[Langerhans cell histiocytosis of jaws: a clinical pathological and immunohistochemical study].
OBJECTIVE
To investigate the pathological and immunohistochemical characteristics of chronic localized Langerhans cell histiocytosis (LCH).


METHODS
HE staining and histopathological observation, mitotic counting and immunohistochemical staining.


RESULTS
22 cases of LCH were included in this study. The most prominent histologic feature was nuclear polymorphism of Langerhans cells (LC). Nuclear sulcus was often noted. Intercellular spaces were also obvious. Mitotic figures were commonly seen (the mean mitotic index was 7.1 under 10 high magnification fields). The mean PCNA index of LC was 14.5%. Other histiocytes and multinuclear cells were CD68 and cathepsin D positive.


CONCLUSIONS
The nuclear polymorphism of LC is of diagnostic value for LCH, LC in the lesions is hyperplastic and neoplastic in nature rather than simple accumulation and the S-100 positive LC are immature precursors of Langerhans cell.
Gao
Y
Y
School of Stomatology, Beijing Medical University, Beijing 100081.
Liu
X
X
Liu
J
J
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007571:Jaw Diseases / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis
D018809:Proliferating Cell Nuclear Antigen