[Prevalence of viral hepatitis G infection in hemodialysis patients and coinfection with viral hepatitis B and C].
The group of infectious agents causing viral hepatitis was extended by another virus the detection of which was published in 1995. This virus is described as virus of hepatitis G (HGV) or GBV-C virus and is included among RNA viruses family Flaviviridae. Detection of HGV is based on reverse transcription with subsequent amplification of the viral nucleic acid by means of a polymerase chain reaction. The authors examined sera of 82 chronically haemodialyzed patients incl. 22 (26.8%) HGV RNA positive ones, whereby coinfection with HBV was proved in 3 specimens (13%). In 6 HGV RNA positive samples anti-HCV positivity was found (27%), incl. one sample where HCV RNA positivity was proved (4.5%). Raised transaminase activity was found only in three patients with HGV RNA positivity (13.6%). From the presented results ensues that haemodialyzed patients are a high risk group for HGV infection.
Klusonová
H
H
UK Praha, Farmaceutická fakulta, Hradec Králové.
Plísková
L
L
Palicka
V
V
Fixa
P
P
D018178:Flaviviridae Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D029407:GB virus C / Q000302:isolation & purification; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D016036:Seroepidemiologic Studies
D012367:RNA, Viral