Modulation of oxidative burst of neutrophils by doxycycline in patients with acute myocardial infarction.
We investigated to what extent doxycycline hydrochloride (DOXY) can modify polymorphonuclear leucocyte (PMN) activity in patients with acute myocardial infarction (AMI). PMN activity was measured in blood samples obtained at 0, 15, 30 and 60 min after DOXY administration. In patients receiving saline, PMN activity did not change over 60 min. In contrast, patients receiving DOXY showed a > or = 10% reduction in PMN activity at 30 and 60 min. These data support the use of DOXY to reduce myocardial cell damage by PMNs in patients with AMI.
Takeshita
Satoshi
S
Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan. stake@blue.ocn.ne.jp
Ono
Yasuo
Y
Kozuma
Ken
K
Suzuki
Masatoshi
M
Kawamura
Yutaka
Y
Yokoyama
Naoyuki
N
Furukawa
Taiji
T
Isshiki
Takaaki
T
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D016897:Respiratory Burst / Q000187:drug effects* / Q000502:physiology
D000900:Anti-Bacterial Agents; D004318:Doxycycline