[Cerebrospinal fluid viral load in HIV-1 positive hemophilic patients treated with HAART].
As HIV seropositive patients with undetectable CSF viral load have a lower likelihood of developing neurologic disease, the determination of CSF viral load levels may be useful to evaluate the efficacy of HAART. We compared plasma viral load levels with HIV-1 RNA CSF levels in 18 hemophilic patients without neurocognitive involvement under HAART. We detected a significant correlation between plasma viral load levels and CSF viral load levels. Fourteen patients with undetectable plasma viral load had undetectable RNA HIV-1 CSF levels as well. Four patients with detectable plasma viral load had detectable HIV-RNA in CSF, but the latter were significantly lower. Viral load is usually lower in non-blood fluids and HAART decreases the viral load in CSF as well as in blood.
Corti
M E
ME
Fundación Argentina de la Hemofilia e Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina. marcelocorti@ciudad.com.ar
Villafañe
M F
MF
Baré
P
P
Alves Rosa
F
F
Cermelj
M
M
Candela
M
M
Pérez Bianco
R
R
Tezanos Pinto
M
M
D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000134:cerebrospinal fluid* / Q000150:complications / Q000188:drug therapy; D015497:HIV-1; D006467:Hemophilia A / Q000097:blood / Q000134:cerebrospinal fluid / Q000821:virology*; D006801:Humans; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid*; D019562:Viral Load
D012367:RNA, Viral