Antioxidative activity of hydroxylamines. ESR spectra of radicals derived from hydroxylamines.
The antioxidative activity of hydroxylamines was evaluated for the oxidation of tetralin at 61 degrees C and linoleic acid micelles in an aqueous dispersion at 37 degrees C, induced by an azo initiator. The antioxidative efficacy of the hydroxylamines for the oxidation of tetralin was smaller than that of alpha-tocopherol. However, the hydroxylamines showed more potent antioxidative activity than that of the alpha-tocopherol against the oxidation of linoleic acid micelles. On the basis of the results of an ESR study and the oxidation product obtained, it is suggested that active position in hydroxylamines depend not only on hydroxyl hydrogen-atom, but also on the allylic hydrogen atom.
Nishiyama
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Department of Applied Chemistry, Faculty of Engineering, Kansai University, Suita, Osaka, Japan. organic@ipcku.kansai-u.ac.jp
Tamekuni
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H
Tachibana
T
T
Kitamura
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H
Saito
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S
D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000737:chemistry*; D019811:Hydroxylamine / Q000737:chemistry* / Q000494:pharmacology*; D009570:Nitriles / Q000737:chemistry; D010084:Oxidation-Reduction / Q000187:drug effects; D013764:Tetrahydronaphthalenes / Q000737:chemistry
D000975:Antioxidants; D005609:Free Radicals; D009570:Nitriles; D013764:Tetrahydronaphthalenes; D019811:Hydroxylamine; C095210:tetralin; C004526:azobis(isobutyronitrile)