New method of synthesis of Vinca alkaloid derivatives.
Vinblastine and vinorelbine analogues have been synthesised by reacting new versatile electrophilic vindoline derivatives with various 3-substituted indoles. The resulting compounds have been evaluated for their antimitotic properties, but exhibited less potent activities in comparison with the standard binary Vinca alkaloids.
Fahy
Jacques
J
Division de Chimie Médicinale V, Centre de Recherche Pierre Fabre, 81106 Castres, France. jacques.fahy@pierre-fabre.com
Thillaye du Boullay
Valérie
V
Bigg
Dennis C H
DC
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D050257:Tubulin Modulators; D014748:Vinca Alkaloids / Q000138:chemical synthesis*
D000972:Antineoplastic Agents, Phytogenic; D050257:Tubulin Modulators; D014748:Vinca Alkaloids