MAP kinase cascades: scaffolding signal specificity.
Scaffold proteins organize many MAP kinase pathways by interacting with several components of these cascades. Recent studies suggest that scaffold proteins provide local activation platforms that contribute to signal specificity by insulating different MAP kinase pathways.
van Drogen
Frank
F
Swiss Institute for Experimental Cancer Research (ISREC), Ch. des Boveresses 155, 1066, Epalinges/VD, Switzerland. Frank.vanDrogen@ISREC.UNIL.CH
Peter
Matthias
M
D005246:Feedback; D020935:MAP Kinase Signaling System; D015398:Signal Transduction; D013379:Substrate Specificity