Large-scale screening of selected Candida maltosa, Debaryomyces hansenii and Pichia anomala killer toxin activity against pathogenic yeasts.
The killer activity of selected crude toxins produced by nine Candida maltosa, Debaryomyces hansenii and Pichia anomala strains was tested at 37 degrees C against 383 strains belonging to 19 pathogenic species of 10 genera (Candida, Clavispora, Cryptococcus, Filobasidiella, Issatchenkia, Kluyveromyces, Pichia, Saccharomyces, Stephanoascus and Trichosporon). The broad killer spectra exhibited by all crude toxins may lead to the development of new antimycotic agents against medically important yeasts.
Buzzini
P
P
Dipartimento di Biologia Vegetale e Biotecnologie Agroambientali, Università di Perugia, Borgo XX Giugno, Italy. pbuzzini@unipg.it
Martini
A
A
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000472:pathogenicity*; D005658:Fungi / Q000187:drug effects*; D055646:Killer Factors, Yeast; D009183:Mycotoxins / Q000494:pharmacology*; D012440:Saccharomyces / Q000472:pathogenicity*; D029701:Saccharomyces cerevisiae Proteins
D000935:Antifungal Agents; C527157:KHR1 protein, S cerevisiae; D055646:Killer Factors, Yeast; D009183:Mycotoxins; D029701:Saccharomyces cerevisiae Proteins; C087906:killer toxin, Pichia