title: Unravelling novel intracellular pathways in cell-based assays.
abstract: The pharmaceutical industry is currently facing several challenges to identify and develop novel drug targets. Traditional drug discovery focussed on a small number of well-characterized gene products. Recently, this picture has changed with the completion of the draft sequence of the human genome, which has led to the identification of thousands of novel genes with unknown or poorly understood function. To cope with this overwhelming number of potential drug target candidates, new strategies for the elucidation of gene function, as well as their involvement in intracellular pathways, are required.
authors.affiliation: Atugen AG, Robert-Rössle-Str. 10, 13125 Berlin, Germany. giese@atugen.com
authors.forename: Klaus
authors.initials: K
authors.lastname: Giese
authors.forename: Jörg
authors.initials: J
authors.lastname: Kaufmann
authors.forename: Gijsbertus J
authors.initials: GJ
authors.lastname: Pronk
authors.forename: Anke
authors.initials: A
authors.lastname: Klippel
mesh_terms: D001681:Biological Assay; D002468:Cell Physiological Phenomena; D002477:Cells / Q000187:drug effects; D004345:Drug Industry / Q000379:methods / Q000639:trends*; D023281:Genomics; D006801:Humans; D010600:Pharmacology / Q000379:methods / Q000639:trends*; D015398:Signal Transduction / Q000187:drug effects*