Crohn's disease.
Crohn's disease is a disorder mediated by T lymphocytes which arises in genetically susceptible individuals as a result of a breakdown in the regulatory constraints on mucosal immune responses to enteric bacteria. Regulation of immune reactivity to enteric antigens has improved understanding of the pathophysiological mechanisms of Crohn's disease, and has expanded therapeutic options for patients with this disorder. Disease heterogeneity is probable, with various underlying defects associated with a similar pathophysiological outcome. Although most conventional drug treatments are directed at modification of host response, therapeutic manipulation of the enteric flora is becoming a realistic option.
Shanahan
Fergus
F
Department of Medicine, Clinical Sciences Building, Cork University Hospital, Cork, Ireland. F.shanahan@ucc.ie
D000818:Animals; D002352:Carrier Proteins; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D047908:Intracellular Signaling Peptides and Proteins; D053473:Nod2 Signaling Adaptor Protein; D011506:Proteins / Q000235:genetics
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D011506:Proteins