[The mechanism and effect of erythromycin in development of pulmonary fibrosis].
OBJECTIVE
To observe the effect of erythromycin on the development of pulmonary fibrosis and explore the new therapy in pulmonary fibrosis.


METHODS
By evaluating the pathologic changes, the synthesis of collagen protein, the level of activity and expression of tumor necrosis factor-alpha (TNF-alpha), the effect of erythromycin was investigated on the rat model of pulmonary fibrosis induced by bleomycin.


RESULTS
The alveolitis alleviated in the first week in treatment group comparing with the control group (142.5 +/- 13.9 mg/g), the synthesis of collagen protein decreased in the fourth week treatment group (96.8 +/- 4.8 mg/g) (q Test P < 0.01).


CONCLUSIONS
Erythromycin may alleviate the process of rat pulmonary fibrosis induced by bleomycin.
Tan
W
W
The Respiratory Department of the First Teaching Hospital of Beijing Medical University, Beijing 100034.
Liu
X
X
He
B
B
Xu
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D003094:Collagen / Q000096:biosynthesis; D004917:Erythromycin / Q000633:toxicity*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000188:drug therapy; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics
D000900:Anti-Bacterial Agents; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D004917:Erythromycin; D003094:Collagen