title: Effects of ingestion of cadmium-polluted rice or low-dose cadmium-supplemented diet on the endogenous metal balance in female rats.
abstract: The concentrations of endogenous metal ions in liver, kidney, and bone tissues of female rats were measured after ingestion of cadmium-polluted rice (1.24 ppm as Cd) or cadmium-supplemented rice (1.24 and 4.96 ppm) for 2 or 4 mo. The metal accumulated mainly in the kidneys and in the liver. The concentration of cadmium (Cd) in the kidneys of rats fed a 1.24-ppm Cd-supplemented diet was significantly higher than in the Cd-polluted rice group. After 2 mo, the levels of iron and sodium in the liver were elevated in the Cd-polluted rice group, but not in the 1.24-ppm Cd-supplemented group, as compared to controls. The zinc concentration in the Cd-polluted rice group was decreased. The concentration of copper in the kidneys was increased for all Cd-containing diet groups. After 4 mo, the effects of Cd on essential metals in the Cd-polluted and 1.24-ppm Cd-supplemented groups had almost disappeared, although several metal ions in selected organs in the 4.96-ppm Cd-supplemented group showed more prominent changes than in the group exposed for 2 mo. These results suggest that the effects of short-term exposure to Cd on essential metal balance are stronger for rice-bound Cd than for inorganic Cd, although the absorption rate of Cd in Cd-polluted rice may be lower than that of cadmium chloride added to rice.
authors.affiliation: Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Oishi
authors.forename: J
authors.initials: J
authors.lastname: Nakagawa
authors.forename: M
authors.initials: M
authors.lastname: Ando
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride / Q000494:pharmacology; D019587:Dietary Supplements; D005260:Female; D005506:Food Contamination; D007501:Iron / Q000378:metabolism; D012275:Oryza / Q000378:metabolism*; D051381:Rats; D015032:Zinc / Q000378:metabolism
chemical_list: D002104:Cadmium; D007501:Iron; D015032:Zinc; D019256:Cadmium Chloride