title: Novel translocation (9;12)(q22;q24) in secondary chondrosarcoma arising from hereditary multiple exostosis.
abstract: We report a new translocation in a patient with a history of hereditary multiple exostosis (HME) who developed a recurrent grade I chondrosarcoma involving the sacrum and retroperitoneum. Karyotypic analysis of the tumor revealed a sole chromosome abnormality t(9;12)(q22;q24.3). To our knowledge, this translocation has not been previously identified in either chondrosarcoma, HME, or related tumor types. Our novel translocation may be related to the sarcomatous degeneration of the pre-existing exostosis.
authors.affiliation: Department of Orthopaedic Surgery, College of Physicians and Surgeons of Columbia University, 622 W. 168th St., PH 11, New York, NY, USA. fl127@columbia.edu
authors.forename: Francis Young-In
authors.initials: FY
authors.lastname: Lee
authors.forename: Mark
authors.initials: M
authors.lastname: Zawadsky
authors.forename: May
authors.initials: M
authors.lastname: Parisien
authors.forename: Mike
authors.initials: M
authors.lastname: Ho
authors.forename: Vundavalli V V S
authors.initials: VV
authors.lastname: Murty
authors.forename: Thottala
authors.initials: T
authors.lastname: Jayaraman
authors.forename: Harold M
authors.initials: HM
authors.lastname: Dick
mesh_terms: D000328:Adult; D000367:Age Factors; D001859:Bone Neoplasms / Q000150:complications / Q000235:genetics*; D002813:Chondrosarcoma / Q000150:complications / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005097:Exostoses, Multiple Hereditary / Q000150:complications / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D012447:Sacrum / Q000473:pathology*; D014178:Translocation, Genetic / Q000235:genetics*