[Correction of the stomach blood flow as a mechanism of anti-ulcer effects of short proline-containing peptides].
Intraperitoneal administration of the PGP did not change basal mucosal blood flow, whereas the PG and GP significantly decreased it. Ethanol and Indomethacin caused a rapid and stable decrease in the blood flow. Administration of the PGP prior to ethanol abolished this effect. Injections of the PGP and PG following Indomethacin administration prevented reduction of the mucosal blood flow. Administration of the GP did not change the blood flow decrease induced with Indomethacin. The mucosal blood flow correction seems to be one of the possible mechanisms of the PGP and PG antiulcer effect. The effect seems to be realised through a change in the CNS activity.
Samonina
G E
GE
M. V. Lomonossov State University, 119899, Vorobievy Gory, Moscow, Russia.
Kopylova
G N
GN
Sergeev
V I
VI
Zhuĭkova
S E
SE
Bakaeva
Z V
ZV
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000098:blood supply*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow
D000897:Anti-Ulcer Agents; D004151:Dipeptides; D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D000431:Ethanol; C057749:prolylglycine; C015248:glycylproline; D011392:Proline; D007213:Indomethacin