title: Successful management and perinatal outcome of pregnancy complicated with myelodysplastic syndrome.
abstract: Pregnancy complicated with myelodysplastic syndrome (MDS) is rare and case management is controversial. We report six cases of MDS that were successfully managed during pregnancy including uneventful transvaginal delivery and satisfactory postpartum clinical prognosis. Two patients with MDS who became pregnant twice had normal uneventful deliveries showing no deterioration of MDS. Our findings suggest that pregnancy should be allowed to full-term in MDS patients, especially those of the refractory anemia type, but strict management should be provided before, during and after pregnancy. Pancytopenia might develop during pregnancy but the likelihood of transformation of MDS to leukemia due to pregnancy is remote.
authors.affiliation: Departments of Obstetrics and Gynecology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. ikebon@net.nagasaki-u.ac.jp
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Hideaki
authors.initials: H
authors.lastname: Masuzaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakayama
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
authors.forename: Khaleque
authors.initials: K
authors.lastname: Newaz Khan
authors.forename: Yuko
authors.initials: Y
authors.lastname: Okita
authors.forename: Emiko
authors.initials: E
authors.lastname: Doi
authors.forename: Masao
authors.initials: M
authors.lastname: Tomonaga
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Ishimaru
mesh_terms: D000328:Adult; D000740:Anemia / Q000235:genetics / Q000473:pathology / Q000628:therapy; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics / Q000628:therapy; D001853:Bone Marrow / Q000473:pathology; D036861:Delivery, Obstetric; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology / Q000628:therapy*; D011256:Pregnancy Outcome; D011379:Prognosis; D013997:Time Factors