Antiviral Chinese medicinal herbs against respiratory syncytial virus.
Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC(50)) ranging from 6.3 to 52.1 microg/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components.
Ma
Shuang-Cheng
SC
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
Du
Jiang
J
But
Paul Pui-Hay
PP
Deng
Xue-Long
XL
Zhang
Yong-Wen
YW
Ooi
Vincent Eng-Choon
VE
Xu
Hong-Xi
HX
Lee
Spencer Hon-Sun
SH
Lee
Song Fong
SF
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects / Q000502:physiology; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy / Q000379:methods / Q000706:statistics & numerical data; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000254:growth & development; D029909:Sophora / Q000737:chemistry; D014407:Tumor Cells, Cultured; D047310:Apigenin
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; D010936:Plant Extracts; C458179:scutellarein; D047310:Apigenin