title: Synthesis and anti-HIV activity of new modified 1,2,3-triazole acyclonucleosides.
abstract: The synthesis of 1,2,3-triazole acyclonucleosides 7a-h via 1,3-dipolar cycloaddition of N-9/N-1-propargylpurine/pyrimidine 2a-h with azido-pseudo-sugar 4 is described and none of them had anti-HIV activity.
authors.affiliation: Laboratoire de Chimie Bio-Organique, Faculté des Sciences Semlalia, Marrakech, Maroc.
authors.forename: H B
authors.initials: HB
authors.lastname: Lazrek
authors.forename: M
authors.initials: M
authors.lastname: Taourirte
authors.forename: T
authors.initials: T
authors.lastname: Oulih
authors.forename: J L
authors.initials: JL
authors.lastname: Barascut
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
authors.forename: C
authors.initials: C
authors.lastname: Pannecouque
authors.forename: M
authors.initials: M
authors.lastname: Witrouw
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D009705:Nucleosides; D014230:Triazoles