Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro.
In vitro effects of catechins and their oligomers linked by C4 --> C8 bonds are major antioxidative components of chocolate and cocoa. Their effects on the susceptibility of human low-density lipoprotein (LDL) to oxidation were evaluated. The strength of the antioxidative activity was measured using copper ions as the radical generator as compared by weight varied in the following order: (+)-catechin > procyanidin B2 > or = (-)-epicatechin > or = procyanidin C1 > cinnamtannin A2. Using 2,2'-azobis (4-methoxy-2,4-dimethylvaleronitrile) (MeO-AMVN) as the radical generator, the order was (-)-epicatechin > or = procyanidin B2 > or = procyanidin C1 > (+)-catechin > or = cinnamtannin A2. It is suggested that these compounds contribute to the activity of cacao products to protect LDL from oxidation.
Osakabe
Naomi
N
Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd., 5-3-1, Chiyoda Sakado 350-0289, Japan. naomi_osakabe@meiji.co.jp
Yasuda
Akiko
A
Natsume
Midori
M
Takizawa
Toshio
T
Terao
Junji
J
Kondo
Kazuo
K
D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000378:metabolism / Q000517:prevention & control; D001391:Azo Compounds / Q000494:pharmacology; D044946:Biflavonoids; D002099:Cacao; D002392:Catechin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism*; D009570:Nitriles / Q000494:pharmacology; D016877:Oxidants / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology; D044945:Proanthocyanidins
D000872:Anthocyanins; D000975:Antioxidants; D001391:Azo Compounds; D044946:Biflavonoids; D008077:Lipoproteins, LDL; D009570:Nitriles; D016877:Oxidants; D028321:Plant Preparations; D044945:Proanthocyanidins; C425558:cinnamtannin A2; C109522:V 70; C479580:procyanidin B2; C017674:procyanidin; D002392:Catechin