title: Birth order effects on nonverbal IQ scores in autism multiplex families.
abstract: Lord (1992) published a brief report showing a trend for decreasing nonverbal IQ scores with increasing birth order in a sample of 16 autism multiplex families, and urged replication in a larger sample. In this report, analyses of nonverbal IQ scores for a sample of 144 autism multiplex families indicated that nonverbal IQ scores were significantly lower in secondborn compared with firstborn siblings with autism. This birth order effect was independent of gender as well as the age differences within sib pairs. No such birth order effects were found for social or communicative deficits as measured by the Autism Diagnostic Interview-Revised (ADI-R), but there was a modest tendency for increased scores for ritualistic behaviors for the firstborn sibs. Further, there were no gender differences on nonverbal IQ scores in this sample. Results are discussed in terms of implications for genetic studies of autism.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5719, USA.
authors.forename: D
authors.initials: D
authors.lastname: Spiker
authors.forename: L J
authors.initials: LJ
authors.lastname: Lotspeich
authors.forename: S
authors.initials: S
authors.lastname: Dimiceli
authors.forename: P
authors.initials: P
authors.lastname: Szatmari
authors.forename: R M
authors.initials: RM
authors.lastname: Myers
authors.forename: N
authors.initials: N
authors.lastname: Risch
mesh_terms: D001321:Autistic Disorder / Q000523:psychology*; D001722:Birth Order / Q000523:psychology*; D002648:Child; D005190:Family / Q000523:psychology*; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D009633:Nonverbal Communication; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D012919:Social Behavior