title: [Serotoninergic processes in cells of early embryos of the sea urchin Paracentrotus lividus].
abstract: Agonists of serotonin receptors generate specific inward currents in the cells of early embryos of sea urchin Paracentrotus lividus. Dose-dependent current generated by 5-HT3-agonist 5-HTQ shows complex volt-amperic characteristics with reversal potential -25 and +15 mV. The 5-HTQ effect seems to be due to the activity of channels of mixed conductivity. The 5-HTQ effect is more obvious during cleavage furrow formation. The findings suggest presence of serotonin receptors in the surface membrane of blastomers and their activity play a certain role in regulation of cellular events during cleavage division in the early sea urchin embryo.
authors.affiliation: N. K. Koltzov Institute of Developmental Biology of the Russian Acad. Sci., 26 Vavilov St., Moscow 117808, Russia.
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Shmukler
authors.forename: E
authors.initials: E
authors.lastname: Tosti
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004625:Embryo, Nonmammalian; D066298:In Vitro Techniques; D008024:Ligands; D008564:Membrane Potentials; D018408:Patch-Clamp Techniques; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000378:metabolism / Q000502:physiology*; D012617:Sea Urchins / Q000196:embryology / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000378:metabolism / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000378:metabolism / Q000494:pharmacology
chemical_list: D008024:Ligands; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists