title: A case of complete necrosis of well-differentiated early hepatocellular carcinoma by percutaneous transhepatic portal embolization.
abstract: The patient was a 49-year-old male under observation for chronic hepatitis B. In July 1997, abdominal ultrasonography showed multiple hyperechoic nodules in the right lobe, the largest with a diameter of 3.5 cm. Abdominal computed tomography did not reveal enhanced nodules, and the patient was hospitalized for suspected multiple liver tumors. All biochemical tests were normal, except for a slight decrease in platelets. The patient was positive for HBs antigen, negative for HBe antigen and positive for anti-HBe antibody. Hepatocellular carcinoma (HCC) with patent portal blood flow was strongly suspected based on the results of various imaging techniques. A tumor biopsy was conducted, and findings of multiple early hepatocellular carcinoma of a well-differentiated type were observed. Based on the HCC stage and liver function, an extensive right hepatectomy was indicated. Before the surgical resection, a percutaneous transhepatic portal embolization (PTPE) was performed using gerfoam sponzel in the right portal vein. Complete necrosis of the tumor lesions was observed in the resected liver. Early HCC thought to have developed multifocally concurrently with chronic inactive hepatitis was observed. It is highly possible that complete necrosis of these tumors occurred due to PTPE, suggesting that they are supplied by the portal blood flow.
authors.affiliation: The Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki-shi, 216-8511, Kanagawa, Japan
authors.forename: Michihiro
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authors.lastname: Suzuki
authors.forename: Shiro
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authors.lastname: Maeyama
authors.forename: Noriaki
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authors.lastname: Okuse
authors.forename: Kouji
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authors.lastname: Nishikawa
authors.forename: Yutaro
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authors.lastname: Kobayashi
authors.forename: Yasuto
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authors.lastname: Takahashi
authors.forename: Chiaki
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authors.lastname: Okuse
authors.forename: Taturo
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authors.lastname: Osada
authors.forename: Takeshi
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authors.lastname: Hayashi
authors.forename: Hiroshi
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authors.lastname: Yotuyanagi
authors.forename: Masao
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authors.lastname: Takatori
authors.forename: Seiichiro
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authors.lastname: Ogata
authors.forename: Toshiyuki
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authors.lastname: Uchikoshi
authors.forename: Shiro
authors.initials: S
authors.lastname: Iino