[Endometrial carcinoma in patients with diabetes mellitus].
OBJECTIVE
The purposes of this study were to analyze the relationship between clinical and pathological risk factors in endometrial cancer and additional diabetes mellitus and to clarify the correlation between additional diabetes mellitus and survival of patients with this disease. -


METHODS
This analyze included 181 patients with endometrial carcinoma who were treated between 1985 and 1995 at the University hospital Mainz. Patients with sarcoma were excluded. For statistical analysis a chi(2)-test was performed for univariat analysis. A Kaplan-Meier procedure was performed for over all survival and disease free interval and COX-Regression for multivariate analysis of independence. -


RESULTS
The mean follow-up period was 49 months. The mean age was 65 years. 21.8 % of the patients had an additional diabetes mellitus. These patients had a significantly deeper infiltration of the Myometrium (p-value = 0.004) and were more likely to have lymphonode metastasis (p-value = 0.02). -


CONCLUSIONS
Our results show a correlation between Diabetes mellitus and adverse prognostic factors witch affects by the rate of lymphonode spread and overall survival.
Steiner
E
E
Universitäts-Frauenklinik, Johannes Gutenberg-Universität Mainz. steiner@mail.uni-mainz.de
Eicher
O
O
Hofmann
M
M
Weikel
W
W
Schmidt
M
M
Pilch
H
H
Knapstein
P G
PG
D000368:Aged; D015992:Body Mass Index; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000401:mortality* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000150:complications / Q000401:mortality* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D005858:Germany; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate