The regulatory action of Radix Astragali on M-cholinergic receptor of the brain of senile rats.
The changes in density of M-cholinergic receptors in different areas of senile rats and the regulatory action of Huang Qi ([symbol: see text] Radix Astragali, a drug for warming yang and replenishing qi) were observed by autoradiography. The results showed that the gray scale displayed in brain sections was clear and mainly distributed in the cortex, hippocampus and striate body, while that due to nonspecific combination was negligible. The gray scale in the cortex, hippocampus and striate body of the experimental group was markedly lower than that in the young control rats, decreased respectively by 24.87%, 14.12% and 12.76% (all P < 0.05); but it was obviously higher than those in the senile control rats, increased respectively by 24.15%, 14.38% and 13.47% (P < 0.05). The data indicate that Huang Qi ([symbol: see text]Radix Astragali) may up-regulate the decreased density of M-cholinergic receptors in the brain of senile rats.
Shi
R
R
Department of Materia Medica, Chest Hospital of Henan Province, Zhengzhou 450003.
He
L
L
Hu
Y
Y
Yi
N
N
Weng
S
S
Cao
Y
Y
D000375:Aging / Q000378:metabolism*; D000818:Animals; D027883:Astragalus Plant; D027885:Astragalus propinquus; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D011976:Receptors, Muscarinic; C027492:Huang Qi