title: Effects of indole and caffeine on cAMP in the ind1 and cfn1 mutant strains of Schizophyllum commune during sexual development.
abstract: The ind1 and cfn1 mutations of Schizophyllum commune express resistance to high concentrations of indole and caffeine respectively, and also affect sexual development. To clarify molecular events caused by the mutations, it was investigated how cAMP levels in S. commune strains respond to externally supplied indole and caffeine. Both compounds increased the cAMP levels in wild-type strains under several culture conditions. During sexual development of the ind1 mutant, the cAMP level in an early stage (hyphal aggregation) was highly increased by addition of indole, and the phenomenon disappeared in a later stage (fruit body formation). For the cfn1 mutants, the incremental increase in cAMP levels by addition of caffeine was smaller than that of wild-type strains.
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minamiminowa, Nagano 399-4598, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Kikuo
authors.initials: K
authors.lastname: Sen
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwama
authors.forename: Partha Pratim
authors.initials: PP
authors.lastname: Samadder
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kurosawa
authors.forename: Hiroshiro
authors.initials: H
authors.lastname: Shibai
mesh_terms: D002110:Caffeine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D007211:Indoles / Q000494:pharmacology*; D009024:Morphogenesis / Q000187:drug effects; D009154:Mutation; D012098:Reproduction / Q000187:drug effects; D012567:Schizophyllum / Q000187:drug effects / Q000254:growth & development*
chemical_list: D007211:Indoles; D002110:Caffeine; C030374:indole; D000242:Cyclic AMP