Estrogen replacement therapy for the potential treatment or prevention of Alzheimer's disease.
Alzheimer's disease (AD) is an irreversible, progressive brain disorder that occurs gradually and results in memory loss, behavior and personality changes, and a decline in cognitive abilities. Although basic biological data suggest that estrogen may have neuroprotective and neuroenhancing functions, a number of studies have produced conflicting findings on the use of estrogen for maintaining cognitive function in older people. This review summarizes clinical studies that have examined the effects of estrogen in women with AD.
Miller
M M
MM
Neuroscience and Neuropsychology of Aging Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
Monjan
A A
AA
Buckholtz
N S
NS
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control*; D003071:Cognition / Q000187:drug effects; D018450:Disease Progression; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*
D020845:Selective Estrogen Receptor Modulators