Ferroportin1: a new iron export molecule?
Ferroportin1 is a newly discovered molecule that may play a role in iron export. It is expressed on the basolateral surfaces of mature enterocytes within the duodenum and in macrophages of the spleen and liver. Furthermore, this protein was found to be expressed in placental syncytiotrophoblasts and may be involved in the supply of maternal iron to the fetus. Sequence analysis of ferroportin1 predicts it has ten transmembrane domains, a reductase site and a basolateral localization signal. In addition, the ferroportin1 mRNA transcript contains an iron response element in its 5' untranslated region. This review is focused on the current state of knowledge on ferroportin1 and the medical implications of this discovery.
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Nghia T V
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The Iron Metabolism and Chelation Group, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia.
Richardson
Des R
DR
D000818:Animals; D027682:Cation Transport Proteins / Q000235:genetics / Q000378:metabolism*; D004386:Duodenum / Q000166:cytology / Q000378:metabolism; D020895:Enterocytes / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008954:Models, Biological; D000098742:Ferroportin
D027682:Cation Transport Proteins; D000098742:Ferroportin; D007501:Iron