In vitro study of the interaction between omeprazole and the metal ions Zn(II), Cu(II), and Co(II).
The purpose of this study was to investigate the possibility of a chemical interaction between omeprazole (OM) and the metal ions Zn(II), Cu(II), and Co(II). Using UV absorption spectroscopy and elemental analysis, it was demonstrated that all of the studied metals form complexes with OM. The spectral changes associated with the complexation reaction were used to obtain the stoichiometry and formation constants of the complexes. In all cases complexes were found to form in 1:2 metal to OM ratio. In the case of cobalt another complex species which appeared as a green precipitate was also evident. Copper was shown to form the complex with the formula Cu3(OM)2 in addition to Cu(OM)2. The complexation of cobalt and copper to OM was found to be time dependent and the time required for the completion of the reaction was determined (about 6 h). Apparent binding constants were also determined.
Hamdan
I I
II
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan. iimad@hotmail.com
D000897:Anti-Ulcer Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D007202:Indicators and Reagents; D009584:Nitrogen / Q000737:chemistry; D009853:Omeprazole / Q000737:chemistry*; D013054:Spectrophotometry, Atomic; D013056:Spectrophotometry, Ultraviolet; D015032:Zinc / Q000737:chemistry*
D000897:Anti-Ulcer Agents; D007202:Indicators and Reagents; D003035:Cobalt; D003300:Copper; D015032:Zinc; D009853:Omeprazole; D009584:Nitrogen