title: Successful treatment of ventriculostomy-related meningitis caused by vancomycin-resistant Enterococcus with intravenous and intraventricular quinupristin/dalfopristin.
abstract: We report a case of ventriculostomy-related meningitis caused by vancomycin-resistant Enterococcus faecium (VRE). The patient was successfully treated with administration of quinupristin/dalfopristin by both intravenous and intraventricular routes. A brief review of the literature is provided, which indicates that optimal management with quinupristin/dalfopristin should include daily intraventricular doses of at least 2 mg.
authors.affiliation: Department of Pharmacy, Wake Forest University Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157, USA. johnwill@wfubmc.edu
authors.forename: John C
authors.initials: JC
authors.lastname: Williamson
authors.forename: Steven S
authors.initials: SS
authors.lastname: Glazier
authors.forename: James E
authors.initials: JE
authors.lastname: Peacock
mesh_terms: D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use*; D016983:Enterococcus / Q000187:drug effects / Q000472:pathogenicity*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007276:Injections, Intraventricular; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D016896:Treatment Outcome; D020713:Vancomycin Resistance; D014696:Ventriculostomy / Q000009:adverse effects*; D014769:Virginiamycin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014769:Virginiamycin; C062940:quinupristin-dalfopristin