title: Optimization of contrast agent volume for helical CT in the diagnostic assessment of patients with severe and multiple injuries.
abstract: OBJECTIVE
  The aim of this study was to determine the optimal amount of contrast agent for helical CT of the trunk during primary radiologic evaluation of polytraumatized patients.
  
  
  METHODS
  Eighty-three patients with severe and multiple injuries (mean age 36.2 years) underwent standardized helical CT examination with administration of a single contrast agent bolus of iohexol (Accupaque 300) at volumes of 120, 150, and 180 ml. Image quality was estimated by two blinded radiologists using a visual analogue scale. Analysis further included density measurements in regions of interest (ROIs) placed in the ascending, descending, and abdominal aorta as well as in the liver and spleen.
  
  
  RESULTS
  The qualitative rating of the contrast agent effect after administration of 150 and 180 ml was significantly better compared with 120 ml [odds ratio (OR) 12.05, 95% confidence interval (CI) 3.50-41.52 and OR 12.14, 95% CI 3.36-43.85, respectively]. A dose increase from 120 to 150 ml resulted in a significantly better enhancement of the abdominal aorta (p = 0.006). The highest dose of 180 ml was not associated with a diagnostic gain in the other ROIs.
  
  
  CONCLUSIONS
  We recommend administration of 150 ml of iohexol as the optimal amount of contrast material for single phase bolus administration in emergency helical CT examination of the chest and abdomen.
authors.affiliation: Department of Radiology, Unfallkrankenhaus Berlin, Germany. grit.rademacher@ukb.de
authors.forename: Grit
authors.initials: G
authors.lastname: Rademacher
authors.forename: Dirk
authors.initials: D
authors.lastname: Stengel
authors.forename: Stefanie
authors.initials: S
authors.lastname: Siegmann
authors.forename: Jan
authors.initials: J
authors.lastname: Petersein
authors.forename: Sven
authors.initials: S
authors.lastname: Mutze
mesh_terms: D000007:Abdominal Injuries / Q000000981:diagnostic imaging; D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage; D008297:Male; D009104:Multiple Trauma / Q000000981:diagnostic imaging*; D013898:Thoracic Injuries / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods*; D015599:Trauma Severity Indices
chemical_list: D003287:Contrast Media; D007472:Iohexol