[Event-related potentials and suicide behavior in patients with affective disorder].
OBJECTIVE
To investigate P300 and contingent negative variations (CNV) of patients with affective disorder and its clinical significance.


METHODS
39 depressives, 22 maniacs and 33 normal controls were included in this study. Both P300 and CNV were recorded in every subject, using a nicolet spirit instrument.


RESULTS
Both depression and mania groups presented prolonged P300-P3b latency and decreased P300-P3 and CNV amplitudes compared with normal controls. Decreased P300 & CNV amplitudes were further related to the history of suicide behavior in the two patient groups.


CONCLUSIONS
The clinical significance of event-related potentials was confirmed in this study, while the biological correlates of suicide behavior need further and intensive study.
Wang
J
J
Shanghai Mental Health Center, Shanghai 200030, China.
Chen
X
X
Lou
F
F
D000328:Adult; D000341:Affective Disorders, Psychotic / Q000503:physiopathology; D001714:Bipolar Disorder / Q000503:physiopathology*; D003265:Contingent Negative Variation / Q000502:physiology*; D003863:Depression / Q000503:physiopathology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D013405:Suicide / Q000523:psychology*