[Corrective effects of tocopherol on changes in indices of the protective activity of phagocytes under the action of the herbicide 2,4-DA].
An experimental study on non-inbred rats indicated the toxic effect of a single dose of the herbicide 2,4-dichlorophenoxyacetic acid amine salt in a dose of 240 mg/kg on phagocytic defense processes appeared as phasic changes in the concentration of peripheral leukocytes, in the microbicidal, absorptive, and oxidative activity of polymorphonuclear leukocytes and peritoneal macrophages till day 60 of the follow-up. The course administration of vitamin E produced a beneficial effect on most study indices under aftereffect of a toxicant, which was mostly manifested in the blood levels of leukocytes and in the microbicidal capacity of phagocytes.
Mufazalova
N A
NA
Medvedev
Iu A
IuA
Basyrova
N K
NK
D015084:2,4-Dichlorophenoxyacetic Acid / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001770:Blood Bactericidal Activity; D003627:Data Interpretation, Statistical; D005500:Follow-Up Studies; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D007958:Leukocyte Count; D017737:Macrophages, Peritoneal / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D013997:Time Factors; D024505:Tocopherols / Q000008:administration & dosage / Q000494:pharmacology*
D000975:Antioxidants; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; D024505:Tocopherols