[Individual radioresistance and principles of its formation].
Individual variability of resistance to a broad range of ionizing radiation was analyzed. Individual radioresistance depends both on physical (radiation type, dose, and distribution along the body, dose rate) and biological (species, strain, sex, body mass of animal etc.) factors. Individual radioresistance is manifested by specific and nonspecific responses of organism to radiation. Three components of individual radioresistance are stable, semistable and labile. The stable component is genetically determined by species, sex, habitus status and radiosensitivity of cells of critical organs. The semistable component is determined by embryogenetic, early postnatal development and reflected in functional activity of the main regulatory systems of the body. The labile component is a parameter of current functional state of an indviduum. The stable and semistable components characterize inborn whereas the labile component--acquired radioresistance.
Darenskaia
N G
NG
Korotkevich
A O
AO
Maliutina
T S
TS
Nasonova
T A
TA
D000818:Animals; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D051379:Mice; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000276:immunology*; D011829:Radiation Dosage; D051381:Rats