[Concentration of interleukin-6 and interleukin-12 in pregnant women infected and noninfected with parvovirus B19].
The aim of the study was to pay attention to the frequency and consequences of Parvovirus B19 infection and observation of IL-6 and IL-12 concentrations in pregnant women who have or have not undergone parvovirus infection. In 32 pregnant women in their first or the next pregnancy with the imminent abortion IgM and IgG antibodies against Parvovirus B19 and serum concentrations of IL-6 and IL-12 were determined using ELISA test. Parvovirus infection was diagnosed in 14 patients, abortion occurred in 5 cases and in 1 case fetal dystrophy was found. In the group of 18 noninfected pregnant women all the pregnancies were finished by healthy newborn delivery. Statistical analysis showed significant increase of IL-6 and IL-12 concentrations in patients infected by parvovirus in comparison to the noninfected group. The estimation of IL-6 concentration may be helpful in evaluation of existing intrauterine inflammation. The concentration of IL-12 should be analysed taking under consideration its role in the cytokine network.
Friedek
D
D
Katedra i Zakład Mikrobiologii Slaskiej Akademii Medycznej w Katowicach.
Romanik
M
M
Rogala-Zawada
D
D
Mercik
R
R
Kłuciński
P
P
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D018664:Interleukin-12 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D010322:Parvoviridae Infections / Q000175:diagnosis / Q000276:immunology*; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000276:immunology* / Q000821:virology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015850:Interleukin-6; D018664:Interleukin-12