Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells.
The lbp gene, which encodes a laminin-binding protein (Lbp) of Streptococcus pyogenes, was found in all S. pyogenes M types. An Lbp-deficient mutant showed a significantly lower efficiency of adhesion to HEp-2 cells than did the wild-type strain. These results indicate that Lbp is one of the important S. pyogenes adhesins.
Terao
Yutaka
Y
Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita-Osaka 565-0871, Japan.
Kawabata
Shigetada
S
Kunitomo
Eiji
E
Nakagawa
Ichiro
I
Hamada
Shigeyuki
S
D001422:Bacterial Adhesion / Q000502:physiology*; D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D001483:Base Sequence; D004269:DNA, Bacterial; D004847:Epithelial Cells / Q000382:microbiology; D016680:Genome, Bacterial; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017474:Receptors, Laminin / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D013297:Streptococcus pyogenes / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014407:Tumor Cells, Cultured
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D007797:Laminin; C447144:Lbp protein, Streptococcus; D017474:Receptors, Laminin