title: Modelling of the coupling between brain electrical activity and metabolism.
abstract: In order to make an attempt at grouping the various aspects of brain functional imaging (fMRI, MRS, EEG-MEG, ...) within a coherent frame, we implemented a model consisting of a system of differential equations, that includes: (1) sodium membrane transport, (2) Na/K ATPase, (3) neuronal energy metabolism (i.e. glycolysis, buffering effect of phosphocreatine, and mitochondrial respiration), (4) blood-brain barrier exchanges and (5) brain hemodynamics, all the processes which are involved in the activation of brain areas. We assumed that the correlation between brain activation and metabolism could be due to either changes in the concentrations of ATP and ADP following activation of Na/K ATPase that result from the changes in ion concentrations, or the involvement, in different phases of metabolism, of a second messenger such as calcium. In this article, we show how this type of model enables interpretation of MRS and fMRI published data that were obtained during prolonged stimulations.
authors.affiliation: INSERM U 483, Université Pierre et Marie Curie, Boîte 23, Paris, France. Agnes.Aubert@snv.jussieu.fr
authors.forename: A
authors.initials: A
authors.lastname: Aubert
authors.forename: R
authors.initials: R
authors.lastname: Costalat
authors.forename: R
authors.initials: R
authors.lastname: Valabrègue
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D004569:Electroencephalography; D004734:Energy Metabolism / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D008962:Models, Theoretical; D009474:Neurons / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D015222:Sodium Channels; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000254:Sodium-Potassium-Exchanging ATPase