The immunopathogenesis of Borna disease virus infection.
Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system. The single-stranded RNA Borna disease virus, a member of Bornaviridae in the order of Mononegavirale, lacks cytopathogenicity both in vitro and in vivo. After experimental infection BDV causes a persistent infection of the central nervous system and induces Borna disease, an immune-mediated encephalomyelitis. The infiltrating immune cells have been characterized as CD4-positive, CD8-positive T-cells, macrophages and B cells. CD8-positive T cells represent the effector cell population exhibiting antigen specificity for the nucleoprotein.
Stitz
Lothar
L
Institute for Immunology, Federal Research Center for Virus Diseases of Animals, Paul-Ehrlich-Strasse 28, D-72076 Tubingen, FRG. lothar.stitz@tue.bfav.de
Bilzer
Thomas
T
Planz
Oliver
O
D000818:Animals; D001890:Borna Disease / Q000276:immunology* / Q000473:pathology / Q000821:virology; D001891:Borna disease virus / Q000276:immunology / Q000472:pathogenicity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D018448:Models, Immunological; D051381:Rats; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D016207:Cytokines