A new water-soluble N-protecting group, 2-(phenyl(methyl)sulfonio)ethyloxycarbonyl tetrafluoroborate, and its application to solid phase peptide synthesis in water.
A new water-soluble N-protecting group, 2-[phenyl(methyl)sulfoniolethyloxycarbonyl tetrafluoroborate, has been prepared and its application to solid phase peptide synthesis in water has been studied. Leu-enkephalin amide was successfully synthesized in water by the solid phase method using this protecting group.
Hojo
K
K
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan.
Maeda
M
M
Kawasaki
K
K
D000577:Amides / Q000737:chemistry; D001881:Borates / Q000737:chemistry*; D001888:Boric Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004745:Enkephalins / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry; D007930:Leucine / Q000737:chemistry; D008956:Models, Chemical; D010452:Peptide Biosynthesis; D014867:Water / Q000737:chemistry*
C457599:2-(phenyl(methyl)sulfonio)ethyloxycarbonyl tetrafluoroborate; D000577:Amides; D001881:Borates; D001888:Boric Acids; D004745:Enkephalins; D007202:Indicators and Reagents; D014867:Water; D007930:Leucine; C098759:fluoroboric acid