Hippocampal volume and incident dementia in geriatric depression.
The authors investigated the role of baseline hippocampal volume on later clinical emergence of dementia in a group of older, non-demented depressed individuals. Subjects were 115 depressed, non-demented participants in a mental health clinical research center. All subjects were screened for dementia and agreed to have a magnetic resonance imaging (MRI) brain scan at baseline. Subjects were clinically evaluated by geriatric psychiatrists quarterly for up to 5 years and received annual neuropsychological testing. Bivariate analyses examined age, gender, race, educational level, baseline depression severity, age at depression onset, baseline Mini-Mental State Exam (MMSE), left and right hippocampal volume, and total cerebral volume. Age, baseline MMSE, total cerebral volume, and having a small left hippocampal volume were associated with later dementia and were included in subsequent survival analysis. Small left hippocampal volume was significantly associated with later dementia (hazard ratio=2.762). Small left hippocampal size on neuroimaging may be a marker for dementia in depressed patients who have not yet met criteria for a clinical diagnosis of a dementing disorder.
Steffens
David C
DC
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. steff001@mc.duke.edu
Payne
Martha E
ME
Greenberg
Daniel L
DL
Byrum
Christopher E
CE
Welsh-Bohmer
Kathleen A
KA
Wagner
H Ryan
HR
MacFall
James R
JR
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000209:etiology; D001057:Apolipoproteins E / Q000235:genetics; D001931:Brain Mapping; D003704:Dementia / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D015140:Dementia, Vascular / Q000209:etiology; D003863:Depression / Q000150:complications* / Q000473:pathology; D004292:Dominance, Cerebral; D005500:Follow-Up Studies; D005838:Genotype; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012307:Risk Factors
D001057:Apolipoproteins E