title: Effects of hokoei-to (pugongying-tang), a Kampo formula, on monoamine content in brain regions and mitogenic activity of splenic lymphocytes in ovariectomized mice.
abstract: Hokoei-to (pugongying-tang) is one of the Kampo formulae clinically used for gynecological disturbances such as lack of lactation and mammary swelling. We investigated the effect of hokoei-to on the nervous and immune systems in ovariectomized mice as a climacteric disorder model. Hokoei-to suppressed the decrease of monoamines in the ventral hippocampus and dorsal hippocampus of ovariectomized mice. It was shown that the hokoei-to could improve the metabolic turnover of dopamine. The mitogenic activity of lymphocytes in the spleen was reduced after ovariectomy; a suppression of this reduced activity was observed in the group given hokoei-to.
authors.affiliation: The Research Division, Oriental Medicine Research Center, The Kitasato Institute, Tokyo, Japan.
authors.forename: Q H
authors.initials: QH
authors.lastname: Song
authors.forename: K
authors.initials: K
authors.lastname: Toriizuka
authors.forename: K
authors.initials: K
authors.lastname: Iijima
authors.forename: T
authors.initials: T
authors.lastname: Yabe
authors.forename: T
authors.initials: T
authors.lastname: Yokozawa
authors.forename: J C
authors.initials: JC
authors.lastname: Cyong
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004298:Dopamine / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D020835:Medicine, Kampo; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D010052:Ovariectomy; D012701:Serotonin / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000187:drug effects
chemical_list: D015306:Biogenic Monoamines; D004365:Drugs, Chinese Herbal; C090387:Hokoei-to; D008934:Mitogens; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid