The effects of succimer chelation therapy on auditory function in rhesus monkeys.
Sixty-six female rhesus monkeys were randomly assigned to three lead exposure conditions (none, from birth to 1 year, and from birth to 2 years) by two chelation treatment (succimer and no succimer) conditions. Blood lead levels were maintained at 35-40 microg/dl beginning shortly after birth and continuing for 1 or 2 years postnatally. There were two separate chelation regimes: 53 and 65 weeks of age. Lead and lead-vehicle dosing were discontinued while succimer was administered. Succimer (or placebo) was administered orally at a dose of 30 mg/kg/day (divided into three doses per day) for 5 days and for 14 additional days at 20 mg/kg/day (divided into two doses per day) for a total 19-day treatment regimen. Auditory function was assessed in these monkeys at least 1 year after lead intake had been discontinued. The outcome measures included tympanometry to assess middle ear function, OAEs to assess cochlear function, and ABRs to assess the auditory nerve and brainstem pathways. There were no significant differences as a function of succimer treatment for any of the tympanometric variables measured. Suprathreshold and threshold distortion product otoacoustic emissions were comparable among the succimer and vehicle groups. However, there was a nonsignificant trend to smaller amplitude distortion products at the highest frequencies assessed (6.4-10.0 kHz). Finally, the auditory evoked response at levels from the auditory nerve to the cerebral cortex did not significantly differ as a function of succimer treatment.
Lasky
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Center for Clinical Research and Evidence-Based Medicine, The University of Texas-Houston Medical School, 6431 Fannin Street, MSB 2.106, Houston, TX 77030-1503, USA. robert.e.lasky@uth.tmc.edu
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Laughlin
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D000158:Acoustic Impedance Tests; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects*; D002614:Chelating Agents / Q000627:therapeutic use*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D007855:Lead Poisoning / Q000188:drug therapy* / Q000503:physiopathology; D008253:Macaca mulatta; D004113:Succimer / Q000627:therapeutic use*
D002614:Chelating Agents; D004113:Succimer