Preparative-scale synthesis of two metabolites isolated from soil treated with zoxium fungicide and kerb herbicide.
The preparation in multigram scale of two metabolites 3-(3,5-dichloro-4-methyl-benzoylamino)-2-hydroxy-3-methyl-pentanoic acid and 3-(3,5-dichloro-benzoylamino)-3-methyl-2-oxo-butyric acid isolated from soil treated with either Zoxium fungicide or Kerb herbicide was efficiently accomplished using a common 5-step synthetic process starting from easily available raw materials.
Michelotti
Enrique L
EL
Rohm and Haas Company, 727 Norristown Road, Spring House, PA 19477-0904, USA. emichelotti@locusdiscovery.com
Borrell
José I
JI
Roemmele
Renee
R
Matallana
Josep L
JL
Teixidó
Jordi
J
Bryman
Lois M
LM
D000577:Amides / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D002087:Butyrates / Q000138:chemical synthesis*; D005659:Fungicides, Industrial / Q000737:chemistry*; D006540:Herbicides / Q000737:chemistry*; D010421:Pentanoic Acids / Q000138:chemical synthesis*; D012989:Soil Pollutants / Q000378:metabolism
D000577:Amides; D001549:Benzamides; D002087:Butyrates; D005659:Fungicides, Industrial; D006540:Herbicides; D010421:Pentanoic Acids; D012989:Soil Pollutants; C451427:zoxamide; C001059:pronamide