Episodic vertigo: central nervous system causes.
Episodic ataxia type 2 is a prototypical episodic vertigo and ataxia syndrome that is caused by mutations in the calcium channel gene CACNA1A. Recent discoveries regarding the molecular mechanisms that underlie this syndrome provide a model for understanding the more common familial episodic vertigo syndromes, particularly those associated with migraine. Vertigo due to cerebrovascular disease can be of peripheral or central origin, and can mimic more benign peripheral vestibular disorders. Small infarcts in the cerebellum and lateral medulla can present with vertigo without other localizing symptoms.
Baloh
Robert W
RW
Department of Neurology, Division of Surgery (Head and Neck), UCLA School of Medicine, Los Angeles, California 90095-1769, USA. rwbaloh@ucla.edu
D015220:Calcium Channels / Q000235:genetics; D002524:Cerebellar Ataxia / Q000150:complications* / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D008881:Migraine Disorders / Q000150:complications / Q000503:physiopathology; D014717:Vertigo / Q000209:etiology* / Q000503:physiopathology*; D020864:Calcium Channels, N-Type
D015220:Calcium Channels; C105656:CACNA1A protein, human; D020864:Calcium Channels, N-Type