Spontaneous resolution of profound hypogammaglobulinemia.
A 3-month-old, full-term female infant was hospitalized with pneumonia and bronchiolitis. Laboratory studies revealed a profoundly low level of IgG (41 mg/dL) and low level of IgA (< 6.67 mg/dL). Other causes of immunodeficiency were ruled out, and there was no evidence of protein loss to account for the low immunoglobulin levels. The immunoglobulin levels normalized over time. Our patient had a transient hypogammaglobulinemia of infancy, with severely low IgG and low IgA levels. We found no other reports of cases with such low values of IgG that proved to be transient.
Yates
A B
AB
Department of Pediatrics, University of Mississippi Medical Center, Jackson, USA.
Shaw
S G
SG
Moffitt
J E
JE
D000361:Agammaglobulinemia / Q000276:immunology*; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D017099:IgG Deficiency; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D012075:Remission, Spontaneous; D013997:Time Factors
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M