title: Octreoscan SPET evaluation in the diagnosis of pancreas neuroendocrine tumors.
abstract: The study describes the results of Octreoscan SPET (OCTSPET) qualitative and semi-quantitative evaluation in 38 patients with suspected pancreatic neuroendocrine tumors. SPET studies were acquired at 4 and 24 hours after the injection of 111-220 MBq of 111-In-pentetreotide (Octreoscan). Qualitative and semi-quantitative evaluations were performed. The semi-quantitative approach was based on the time course of Tumor/Non Tumor ratios (TNTinc) from 4 and 24 hours. The OCTSPET results were true positive in 18 of 19 patients (10 gastrinoma, 5 insulinoma, 1 neuroendocrine tumor, 1 glucagonoma and 1 carcinoid) and false negative in one insulinoma. Besides, 20 of 38 patients (52%) had clinical plans modified after OCTSPET; OCTSPET was the only positive diagnostic test in 14 of 19 patients (73%) and guided the surgery decision in 14 of 25 patients (56%). In conclusion, these data indicate that Octreoscan represents an excellent tool for the diagnosis of pancreatic neuroendocrine tumors.
authors.affiliation: Nuclear Medicine Unit, Careggi Hospital Florence, Italy. mednuc1@ao-careggi.toscana.it
authors.forename: V
authors.initials: V
authors.lastname: Briganti
authors.forename: M
authors.initials: M
authors.lastname: Matteini
authors.forename: P
authors.initials: P
authors.lastname: Ferri
authors.forename: L
authors.initials: L
authors.lastname: Vaggelli
authors.forename: A
authors.initials: A
authors.lastname: Castagnoli
authors.forename: C
authors.initials: C
authors.lastname: Pieroni
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013004:Somatostatin / Q000031:analogs & derivatives; D014057:Tomography, X-Ray Computed
chemical_list: D007205:Indium Radioisotopes; D013004:Somatostatin; C081788:pentetreotide