title: Mannose-6-phosphate receptors as a molecular indicator of maturation of epididymal sperm.
abstract: This review discusses some of the changes in sperm during maturation within the context of current concepts of membrane structure and fertilization. Mammalian sperm are surrounded by a limiting plasma membrane that undergoes remodeling during passage through the epididymis. This process confers on the gamete vigorous motility and the ability to fertilize the egg. The repositioning of some surface proteins may follow redistribution of lipids in the plasmalemma, and thus represent a critical step in the maturation of the gametes. Among the various affected proteins of the sperm plasmalemma, mannose-6-phosphate receptors undergo redistribution as the gametes transit through the epididymal duct. The authors summarize their studies of the redistribution of phosphomannosyl receptors during maturation of sperm and discuss possible roles of these glycoproteins in the fertilizing capability of sperm.
authors.affiliation: Instituto de Histologia y Embriologia, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina. sbelmont@fmed2.uncu.edu.ar
authors.forename: S A
authors.initials: SA
authors.lastname: Belmonte
authors.forename: P S
authors.initials: PS
authors.lastname: Romano
authors.forename: M A
authors.initials: MA
authors.lastname: Sosa
mesh_terms: D000818:Animals; D004822:Epididymis / Q000166:cytology*; D006801:Humans; D008297:Male; D017527:Receptor, IGF Type 2 / Q000378:metabolism*; D013094:Spermatozoa / Q000502:physiology*
chemical_list: D017527:Receptor, IGF Type 2