[Effects of ionizing radiation and xenobiotics on the spermatogenic epithelium of laboratory animals].
Intact BALB/c and CBA mice differ in the overall cellularity of the spermatogenous epithelium, in the number of normal and pathological multinuclear cells. Exposure to small-dose radiation (0.25 and 1 Gy) causes profound changes in the spermatogenous epithelium in BALB/c mice. Then the increase in the abnormal forms of multinuclear and uninuclear cells leads to the disintegration and elimination of such cells, which affects the overall cellularity of the spermatogenous epithelium. A reduction in the proportion of multicellular cells, a compensatory-and-protective response that promotes the maintenance of the size of sex cells at the level optimal for fertilization. Upon small-dose exposure of rats to sixvalent chromium, there is a decrease in the whole population of germinitive cells and an increase in the multinuclear spermatocytes and spermatids. The rise in multinuclear cells is indicative of retarded cell maturation and differentiation at some stages of spermatogenesis, which reduces the number of spermatogenous cells.
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D000818:Animals; D002857:Chromium / Q000009:adverse effects; D004396:Coloring Agents / Q000009:adverse effects; D003627:Data Interpretation, Statistical; D004847:Epithelial Cells / Q000187:drug effects / Q000528:radiation effects; D004848:Epithelium / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011192:Potassium Dichromate / Q000008:administration & dosage / Q000009:adverse effects; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects* / Q000528:radiation effects*; D013737:Testis / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D015262:Xenobiotics / Q000009:adverse effects
D004396:Coloring Agents; D015262:Xenobiotics; D002857:Chromium; D011192:Potassium Dichromate