Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients.
The presence of the long (l) variant of the serotonin (5-hydroxytryptamine: 5-HT) transporter gene-linked polymorphic region (5-HTTLPR) is reported to be associated with a more favorable and faster antidepressant effect of selective serotonin reuptake inhibitors in Caucasians. The frequency of the l allele is lower in Japanese than in Caucasians; therefore, the antidepressant effect of fluvoxamine can be not as good in Japanese as in Caucasians. The authors investigated whether 5-HTTLPR was associated with the antidepressant response to fluvoxamine in 66 Japanese patients with major depressive disorder in a protocolized-dosing 6-week study. The short (s) allele frequency was significantly higher in the responsive individuals than in the nonresponsive ones (P = .010). The present study suggests that fluvoxamine is not less effective in depressive patients carrying the s allele than in the ones carrying the l allele and it is not less effective in Japanese than in Caucasians.
Yoshida
Keizo
K
Department of Psychiatry, Akita University School of Medicine, Japan. cxw01076@nifty.com
Ito
Kenichi
K
Sato
Kazuhiro
K
Takahashi
Hitoshi
H
Kamata
Mitsuhiro
M
Higuchi
Hisashi
H
Shimizu
Tetsuo
T
Itoh
Kunihiko
K
Inoue
Kazuyuki
K
Tezuka
Takehiko
T
Suzuki
Toshio
T
Ohkubo
Tadashi
T
Sugawara
Kazunobu
K
Otani
Koichi
K
D000328:Adult; D000368:Aged; D000483:Alleles; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002352:Carrier Proteins / Q000235:genetics*; D016009:Chi-Square Distribution; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D016666:Fluvoxamine / Q000627:therapeutic use*; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000187:drug effects; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins
D000928:Antidepressive Agents; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D016666:Fluvoxamine