title: [A study on the effect of house dust mite on interleukin-10 secretion of peripheral blood lymphocytes in patients with allergic asthma].
abstract: OBJECTIVE
  To investigate the relationship between interleukin (IL)-10 and allergic asthma, and the effect of antigen on IL-10.
  
  
  METHODS
  The supernatant of cultured peripheral blood lymphocytes (PBLC) from 20 patients with allergic asthma and 20 normal subjects with different stimuli [home-dust-mite (HDM) or dexamethasone] was determined for IL-10, by means f enzyme-linked immunosorbent assay.
  
  
  RESULTS
  (1) IL-10 was significantly decreased in asthma group, as compared with the control group (P < 0.01); (2) Less IL-10 was released in HDM-stimulated PBLC in asthma (P < 0.01); (3) IL-10 was obviously increased in dexamethason-stimulated whether in the asthma or in the control group.
  
  
  CONCLUSIONS
  The diminished IL-10 production from PBLC could be related to asthmatic attack in patients with allergic asthma. Dexamethason might exert, at least, a part of anti-inflammatory activity by inducing IL-10 secretion of PBLC.
authors.affiliation: Division of Respiratory Medicine, The Second Hospital, Shanxi Medical University, Taiyuan 030001.
authors.forename: M
authors.initials: M
authors.lastname: Song
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001249:Asthma / Q000276:immunology*; D002478:Cells, Cultured; D002648:Child; D003907:Dexamethasone / Q000494:pharmacology; D004391:Dust; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology*
chemical_list: D004391:Dust; D016753:Interleukin-10; D003907:Dexamethasone