Successful treatment of ocular leishmaniasis.
OBJECTIVE
To report successful treatment of a case of ocular leishmaniasis with combined stibogluconate and allupurinol.


METHODS
A 32-year-old physician developed a non-tender reddish chalazion like lesion in his right lower lid, associated with conjunctivitis and nodular episcleritis. Biopsy of the lesion in his eyelid and conjunctiva disclosed a dense inflammatory response including histiocytes containing typical leishmania organisms.


RESULTS
Therapy with stibogluconate, both intralesional and intramuscular, was initiated with some improvement. However recurrence of the lesion occurred. Systemic retreatment with combined stibogluconate and allupurinol led to complete healing of the lesion.


CONCLUSIONS
Ocular leishmaniasis is a rare and potentially blinding disorder. Combined stibogluconate and allupurinol may be an effective therapy in such cases.
Abrishami
M
M
Shaheed Beheshti University of Medical Sciences, Labbafinejad Medical Center, Ophthalmology Department and Eye Research Center, Tehran, Iran. labaffi@hotmail.com
Soheilian
M
M
Farahi
A
A
Dowlati
Y
Y
D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage; D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage; D000967:Antimony Sodium Gluconate / Q000008:administration & dosage*; D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D001706:Biopsy / Q000379:methods; D004359:Drug Therapy, Combination; D015822:Eye Infections, Parasitic / Q000188:drug therapy* / Q000473:pathology; D005141:Eyelid Diseases / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007891:Leishmania / Q000302:isolation & purification; D007896:Leishmaniasis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012008:Recurrence
D000963:Antimetabolites; D000981:Antiprotozoal Agents; D000493:Allopurinol; D000967:Antimony Sodium Gluconate