title: [Hypolipidemic drugs--ileal Na+/bile acid cotransporter inhibitors (S-8921 etc)].
abstract: The ileal Na+/bile acid cotransporter (IBAT) maintains the reabsorption of bile acids from the ileum in the enterohepatic circulation of bile acids. Interruption of the enterohepatic circulation of bile acids by bile acid sequestrants or partial ileal bypass surgery can cause a significant decrease of serum cholesterol in animals and human patients. Inhibition of IBAT by specific IBAT inhibitors such as S-8921 has been proven to lower serum cholesterol in a variety of experimental animals. IBAT inhibitors, a new class of hypocholesterolemic drugs may be used alone or in combination with HMG-CoA reductase inhibitors in the treatment of hypercholesterolemia with low dosage and high compliance.
authors.affiliation: Developmental Research Laboratories, Shionogi & Co. LTD.
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Ichihashi
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D015195:Drug Design; D004764:Enterohepatic Circulation; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D000960:Hypolipidemic Agents; D007082:Ileum / Q000378:metabolism; D009284:Naphthols / Q000494:pharmacology / Q000627:therapeutic use; D029363:Organic Anion Transporters, Sodium-Dependent; D027981:Symporters; D013841:Thiazepines / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C095410:2164U90; D001647:Bile Acids and Salts; D002352:Carrier Proteins; D000960:Hypolipidemic Agents; D009284:Naphthols; D029363:Organic Anion Transporters, Sodium-Dependent; D027981:Symporters; D013841:Thiazepines; C071908:sodium-bile acid cotransporter; C106517:S 8921; D002784:Cholesterol