[The role of Werner's syndrome gene in the genetic susceptibility to the type 2 diabetes in Chinese population].
OBJECTIVE
To test the hypothesis that Werner's syndrome gene (WRN) contributes to the genetic susceptibility to the type 2 diabetes in Chinese population.


METHODS
Polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) method was used to test the distribution of a polymorphism (Cys1367Arg ) of the WRN gene in 241 type 2 diabetes patients and 108 normal control subjects.


RESULTS
The frequency of "R" allele of the WRN gene in type 2 diabetes patients whose diagnosis age >/= 45 was significantly increased as compared with that in the control subjects (9.6% vs 4.6%, P = 0.04).


CONCLUSIONS
The high frequency of allele "R" of the WRN gene in early onset Chinese type 2 diabetes patients suggests that the WRN gene may contribute to the genetic susceptibility of type 2 diabetes in Chinese population through either directly causing diabetes or interacting with the diabetogenic gene.
Luo
Y
Y
Department of Endocrinology, People's Hospital, Beijing Medical University, Beijing 100044, China.
Ji
L
L
Han
X
X
D000328:Adult; D000367:Age Factors; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D004265:DNA Helicases / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005090:Exodeoxyribonucleases; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length; D053484:RecQ Helicases; D014898:Werner Syndrome / Q000235:genetics*; D000071657:Werner Syndrome Helicase
D005090:Exodeoxyribonucleases; D004265:DNA Helicases; D053484:RecQ Helicases; C098785:WRN protein, human; D000071657:Werner Syndrome Helicase