Synthesis of hindered 1-arylnaphthalene derivatives via ring expansion of benzocyclobutenones.
[reaction: see text] Various 1-arylnaphthalenes, including highly substituted derivatives, are accessible via a simple two-step process. Treatment of alkenylbenzocyclobutenones with aryllithium provides two-carbon expanded dihydronaphthalenes, which are readily dehydrated by MsCl-Et(3)N or PPTS in MeOH.
Hamura
Toshiyuki
T
Department of Chemistry, Tokyo Institute of Technology, and CREST, Japan Science and Technology (JST) Corporation, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
Miyamoto
Makoto
M
Matsumoto
Takashi
T
Suzuki
Keisuke
K