Selective accumulation of type 1 effector cells expressing P-selectin ligand and/or alpha(4)beta(7)-integrin at the lesions of autoimmune gastritis.
T(h)1 cells but not T(h)2 cells accumulate at the inflamed gastric mucosa (GM), while both subsets co-exist in the regional lymph node (RLN) in a murine experimental model for autoimmune gastritis (AIG). To understand the relationship between the immuno-microenvironment and effector localization in GM versus RLN of AIG-bearing mice, cells or tissue sections were stained with several mAb against adhesion molecules. The expression of RNA of various cytokines at these contrasting sites was also assessed. IFN-gamma-producing memory CD4(+) (T(h)1) and CD8(+) T cells as well as IL-12-producing mature macrophages which express P-selectin ligand and/or alpha(4)beta(7)-integrin selectively accumulated in the inflamed GM. Vessel endothelium at the site of infiltration expressed those counter-receptors, P-selectin and mucosal adressin cell adhesion molecule-1. Therefore, the tissue destruction of target tissue in autoimmune diseases might be promoted by a vicious circle between the selective accumulation of type 1 effectors mediated by multiple adhesion molecules and following an unusual type 1-biased microenvironment away from the type 2 response.
Katakai
Tomoya
T
Center for Molecular Biology and Genetics, Kyoto University, 53 Shogoin-kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Mori
Kazuhiro J
KJ
Masuda
Tohru
T
Shimizu
Akira
A
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D015815:Cell Adhesion Molecules; D005756:Gastritis / Q000276:immunology*; D007136:Immunoglobulins / Q000032:analysis; D016023:Integrins / Q000032:analysis*; D007371:Interferon-gamma / Q000096:biosynthesis; D018664:Interleukin-12 / Q000096:biosynthesis; D008264:Macrophages / Q000502:physiology; D008562:Membrane Glycoproteins / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C; D009088:Mucoproteins / Q000032:analysis; D018417:Th1 Cells / Q000502:physiology*
D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins; C489082:Madcam1 protein, mouse; D008562:Membrane Glycoproteins; D009088:Mucoproteins; C084882:P-selectin ligand protein; C071777:integrin alpha4beta7; D018664:Interleukin-12; D007371:Interferon-gamma