Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics.
The antibacterial activities of cationic steroid antibiotics and cationic peptide antibiotics have been compared. Depolarization of bacterial membranes, activation of bacterial stress-related gene promoters, and changes in bacterial morphologies caused by these antibiotics suggest that cationic steroid and peptide antibiotics share mechanistic aspects. Modified cationic steroid antibiotics display improved selectivity for prokaryotic cells over eukaryotic cells presumably due to increased charge recognition.
Ding
Bangwei
B
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA.
Guan
Qunying
Q
Walsh
Joshua P
JP
Boswell
J Scott
JS
Winter
Tim W
TW
Winter
Erica S
ES
Boyd
Stephanie S
SS
Li
Chunhong
C
Savage
Paul B
PB
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology*; D002412:Cations; D002462:Cell Membrane / Q000187:drug effects; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D005798:Genes, Bacterial; D008163:Luminescent Measurements; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects / Q000648:ultrastructure; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012486:Salmonella typhimurium / Q000187:drug effects / Q000254:growth & development; D013050:Spectrometry, Fluorescence; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000254:growth & development; D029867:Xenopus Proteins
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D002412:Cations; D013256:Steroids; D029867:Xenopus Proteins; C053300:magainin 1 peptide, Xenopus; C031161:cecropin A