[Pathogenicity of bacteria and the actin cytoskeleton].
Actin system of eukaryotic cells creates the driving force for alteration of the phagocytic cytoplasmatic membrane shape, which is needed for cell movement in the space and for microorganism capturing. Manipulation by actin cytoskeleton mediated through specialized bacterial products can promote proliferation of bacteria in the host. Published reports indicate that bacterial regulation of the actin system activity can be carried out by two modes: 1) by bacterial interactions with surface receptors regulating the cytoskeleton status and 2) by introduction of bacterial products targeted to the cytoskeleton components into the cells. Intracellular pathogens (Legionella) possess ligands which interact with eukaryotic receptors and type IV secretion system fit for translocation of heretofore unknown effector molecules into the cytoplasm. This can result in stimulation of actin polymerization activity and accelerated phagocytosis of the bacteria with rapid multiplication in tissues. By contrast, representatives of extracellular pathogens (Clostridium) produce substances penetrating inside the eukaryotic cells and destroying the actin network, thus making capturing and intracellular digestion of these microorganisms impossible.
Belyĭ
Iu F
IuF
N. F. Gamaleya Institute of Epidemiology and Microbiology.
D000199:Actins / Q000502:physiology*; D003013:Clostridium / Q000472:pathogenicity*; D003599:Cytoskeleton / Q000502:physiology*; D007875:Legionella / Q000472:pathogenicity*; D010587:Phagocytosis
D000199:Actins