Periodontal regeneration by FGF-2 (bFGF) in primate models.
We recently demonstrated that a topical application of basic fibroblast growth factor (FGF-2; bFGF) to alveolar bone defects in beagle dogs enhanced periodontal regeneration. The purpose of this study was further characterization of the biological effects of FGF-2 in non-human primates. Thirty-two inflamed furcation class II defects were surgically created in 4 male primates. The gelatinous carrier alone or the carrier containing 0.1 or 0.4% human recombinant FGF-2 was topically applied to the defects and compared with no treatment. Eight weeks after application, the periodontal regeneration in those defects was analyzed. In all FGF-2-treated sites, significant periodontal regeneration was dose-dependently observed in greater amounts than in the carrier-treated or non-treated sites. No instances of epithelial down-growth, ankylosis, or root resorption were observed in the FGF-2-treated sites. These results indicate that a topical application of FGF-2 can enhance considerable periodontal regeneration in surgically created furcation class II defects of non-human primates.
Takayama
S
S
Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Japan.
Murakami
S
S
Shimabukuro
Y
Y
Kitamura
M
M
Okada
H
H
D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D001861:Bone Regeneration; D003739:Dental Cementum / Q000502:physiology; D004337:Drug Carriers; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D017823:Furcation Defects / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D020100:Hydrogels; D008252:Macaca fascicularis; D008297:Male; D023421:Models, Animal; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D012038:Regeneration
D004337:Drug Carriers; D020100:Hydrogels; D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2