title: CD56-Positive cutaneous lymphoma with multicentric Castleman's disease-like systemic manifestations.
abstract: We report a 55-year-old Japanese male with CD56+ cutaneous lymphoma. The patient had multiple cervical lymphadenopathy, a red nodule on his neck, and parotid gland nodularity. Histologic features of the biopsied cervical lymph node showed follicular hyperplasia with numerous plasma cells. A biopsied skin specimen of the nodule on his neck demonstrated dense infiltration of atypical large lymphocytes into the dermis. Immunohistochemical study of this specimen revealed CD3+, CD4+, and CD56+ expression in the majority of neoplastic cells. Polymerase chain reaction assays for the detection of Epstein-Barr virus sequences were positive for lymph node and skin DNA. Laboratory examinations showed polyclonal gammopathy, pancytopenia, and high serum interleukin-6 levels. These clinical and histological findings resembled those of multicentric Castleman's disease.
authors.affiliation: Department of Dermatology, Fraternity Memorial Hospital, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Amo
authors.forename: F
authors.initials: F
authors.lastname: Ogata
authors.forename: S
authors.initials: S
authors.lastname: Okabe
authors.forename: K
authors.initials: K
authors.lastname: Yonemoto
authors.forename: K
authors.initials: K
authors.lastname: Katsuoka
mesh_terms: D019002:CD56 Antigen / Q000378:metabolism*; D005871:Castleman Disease / Q000175:diagnosis* / Q000473:pathology; D017931:DNA Primers; D004279:DNA, Viral / Q000302:isolation & purification; D003937:Diagnosis, Differential; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009333:Neck; D016133:Polymerase Chain Reaction
chemical_list: D019002:CD56 Antigen; D017931:DNA Primers; D004279:DNA, Viral