title: PGP9.5 as a marker for invasive colorectal cancer.
abstract: OBJECTIVE
  We proved recently that PGP9.5-negative pancreatic cancer patients had significantly better survival rates compared with those who were PGP9.5 positive, and PGP9.5 may be a novel marker for indicating the prognosis of pancreatic cancer patients. In this study, we examined the expression of PGP9.5 in primary colorectal cancers using immunohistochemistry and correlated the result with the clinicopathological features.
  
  
  RESULTS
  Of 74 colorectal cancer specimens examined, 33 cases (46%) showed positive staining with PGP9.5 in most tumor cells, whereas no PGP9.5 expression was detected in adjacent normal epithelium. Subsequently, we correlated PGP9.5 expression in tumors with the clinicopathological features of affected patients and found two significant differences in maximal tumor size and the extent of tumor (P = 0.035 and 0.019, respectively).
  
  
  CONCLUSIONS
  This result suggests that PGP9.5 expression is related to tumor progression and may be useful as a marker for invasive colorectal cancer.
authors.affiliation: Second Department of Surgery, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Hibi
authors.forename: Tsunenobu
authors.initials: T
authors.lastname: Takase
authors.forename: Ekmel
authors.initials: E
authors.lastname: Tezel
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakayama
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kasai
authors.forename: Katsuki
authors.initials: K
authors.lastname: Ito
authors.forename: Seiji
authors.initials: S
authors.lastname: Akiyama
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Akimasa
authors.initials: A
authors.lastname: Nakao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015153:Blotting, Western; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011379:Prognosis; D012307:Risk Factors; D013869:Thiolester Hydrolases / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase
chemical_list: D014408:Biomarkers, Tumor; D009419:Nerve Tissue Proteins; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase