Vidalenolone, a novel phenolic metabolite from the tropical red alga Vidalia sp.
The Indonesian red alga Vidalia sp. was identified as a candidate for fractionation because its crude lipid extract showed activity in a mechanism-based anticancer assay (Fyn SH2-inhibitory activity). A chemically novel phenolic metabolite, vidalenolone, as well as two previously described and structurally simple phenols, were isolated as SH2-inactive substances. Their structures were determined by an interplay of spectroscopic methods, principally 2D NMR, and reference to literature data.
Yoo
Hye-Dong
HD
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
Ketchum
Sharon O
SO
France
Dennis
D
Bair
Ken
K
Gerwick
William H
WH
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D007214:Indonesia; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D010636:Phenols; C449756:vidalenolone