title: Susceptibility to telithromycin in 1,011 Streptococcus pyogenes isolates from 10 central and Eastern European countries.
abstract: Among 1,011 recently isolated Streptococcus pyogenes isolates from 10 Central and Eastern European centers, the MICs at which 50% of isolates are inhibited (MIC(50)s) and the MIC(90)s were as follows: for telithromycin, 0.03 and 0.06 microg/ml, respectively; for erythromycin, azithromycin, and clarithromycin, 0.06 to 0.125 and 1 to 8 microg/ml, respectively; and for clindamycin, 0.125 and 0.125 microg/ml, respectively. Erythromycin resistance occurred in 12.3% of strains. Erm(A) [subclass erm(TR)] was most commonly encountered (60.5%), followed by mef(A) (23.4%) and erm(B) (14.5%). At <0.5 microg/ml, telithromycin was active against 98.5% of the strains tested.
authors.affiliation: Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nagai
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
authors.forename: Todd A
authors.initials: TA
authors.lastname: Davies
authors.forename: Linda M
authors.initials: LM
authors.lastname: Kelly
authors.forename: Dianne B
authors.initials: DB
authors.lastname: Hoellman
authors.forename: Arjana Tambic
authors.initials: AT
authors.lastname: Andrasevic
authors.forename: Liga
authors.initials: L
authors.lastname: Drukalska
authors.forename: Waleria
authors.initials: W
authors.lastname: Hryniewicz
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: Jana
authors.initials: J
authors.lastname: Kolman
authors.forename: Jolanta
authors.initials: J
authors.lastname: Miciuleviciene
authors.forename: Marina
authors.initials: M
authors.lastname: Pana
authors.forename: Lena
authors.initials: L
authors.lastname: Setchanova
authors.forename: Marianne Konkoly
authors.initials: MK
authors.lastname: Thege
authors.forename: Helena
authors.initials: H
authors.lastname: Hupkova
authors.forename: Jan
authors.initials: J
authors.lastname: Trupl
authors.forename: Pavla
authors.initials: P
authors.lastname: Urbaskova
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology; D005061:Europe, Eastern; D005798:Genes, Bacterial; D006801:Humans; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D004917:Erythromycin; D017963:Azithromycin; C106791:telithromycin