[Experimental study on effect of folium Ginkgo biloba in treating pulmonary interstitial fibrosis in rats].
OBJECTIVE
To evaluate the therapeutic effect and mechanism of folium Ginkgo biloba (FGB) in treating pulmonary interstitial fibrosis (PIF) induced by bleomycin in rats.


METHODS
PIF models of bleomycin-A5-induced pulmonary fibrosis were established in rats, they were treated by Bailuda, a preparation of FGB, and the pathological changes, collagen protein level, nuclear factor kB(NF-kB) activity, transforming growth factor beta (TGF-beta) mRNA expression and protein level of the lung tissue were measured.


RESULTS
In the Bailuda treated group after treatment, amelioration of the pulmonary alveolitis and fibrosis were shown in pathological section (P < 0.05) and collagen protein content was lesser (P < 0.01) as compared with those in the model control group. After 1 week of Bailuda treatment, the NF-kB activity of pulmonary alveola macrophage lowered by 47.3%, and levels of TGF-beta mRNA expression and protein were all decreased (P < 0.05).


CONCLUSIONS
Bailuda has definite effect in treating PIF. The mechanism may be through inhibiting the activity of NF-kB, decreasing TGF-beta mRNA expression and protein, so as to ameliorate the inflammation and fibrosis.
Chen
J
J
Department of Pulmonary Medicine, First Hospital of Beijing Medical University, Beijing (100034).
He
B
B
Liu
X
X
D000818:Animals; D001761:Bleomycin; D003094:Collagen / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D020441:Ginkgo biloba; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D016328:NF-kappa B; D016212:Transforming Growth Factor beta; D001761:Bleomycin; D003094:Collagen