title: Cardiotoxicity in imipramine intoxication: report of one case.
abstract: Imipramine is the most commonly prescribed tricyclic antidepressant of acute life threatening self-poisoning. We report a 15-month-old boy of accidental poisoning with imipramine, who developed generalized tonic-clonic convulsions and drug-related cardiac conduction abnormalities with PR prolongation, QRS widening, and QTc lengthening. The patient's imipramine level was 1389 ng/ml. The rapid resolution of intraventricular conduction delay and normalization of the QRS-T complexes after gastric lavage, installation of activated charcoal and alkalinization of the blood strongly implicates imipramine intoxication in the etiology of the cardiotoxicity. The patient made a full recovery without neurological sequelae.
authors.affiliation: Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan.
authors.forename: M H
authors.initials: MH
authors.lastname: Lin
authors.forename: K L
authors.initials: KL
authors.lastname: Hung
authors.forename: N K
authors.initials: NK
authors.lastname: Wang
authors.forename: C T
authors.initials: CT
authors.lastname: Shen
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D004562:Electrocardiography / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D007099:Imipramine / Q000506:poisoning*; D007223:Infant; D008297:Male
chemical_list: D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine