Detection of mis-specified relationships in inbred and outbred pedigrees.
Genome screen data collected for linkage analysis can be used to detect pedigree errors. We have developed methods applicable to a broad range of relationships. We discuss applications of our methods to data on asthma, in which we detect a number of likely mis-specified relative pairs. We propose a graphical method for error detection in complex inbred pedigrees, with application to the Hutterites.
Sun
L
L
Department of Statistics, University of Chicago, Chicago, IL 60637, USA.
Abney
M
M
McPeek
M S
MS
D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D003241:Consanguinity; D005260:Female; D005820:Genetic Testing; D005828:Genetics, Population; D016678:Genome; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008432:Mathematical Computing; D010375:Pedigree; D012984:Software; D018433:Twin Studies as Topic / Q000706:statistics & numerical data