[Effects of activin and follistatin on FSH receptor mRNA expression of cultured Shao duck granulosa cells].
The aim of this study was to investigate the action of activin and follistatin either alone or in combination on FSH receptor mRNA expression. The results showed that activin alone increased FSH receptor mRNA level in the presence or absence of FSH in cultured granulosa cells, and the stimulating effect of activin on FSH receptor level was dose-dependent. This effect of activin was inhibited by FSP treatment which alone had no effect on FSH receptor expression. From the results, it can be concluded that activin and follistatin both exert autocrine actions on granulosa cells, and the two factors, possibly by regulating FSH receptor expression, may play important roles in follicular development.
Fu
Y
Y
Animal Science College of Zhejiang University, Hangzhou 310029, China.
Niu
D
D
Ruan
H
H
Yu
X P
XP
Chen
G
G
He
G Q
GQ
D028341:Activins / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D004372:Ducks; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D038681:Follistatin; D006107:Granulosa Cells / Q000187:drug effects* / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis*; D011962:Receptors, FSH / Q000235:genetics*
D038681:Follistatin; D012333:RNA, Messenger; D011962:Receptors, FSH; D028341:Activins; D005640:Follicle Stimulating Hormone