Ibogaine interferes with motivational and somatic effects of naloxone-precipitated withdrawal from acutely administered morphine.
It has been reported that ibogaine interferes with somatic withdrawal reactions in rats chronically treated with morphine. The present experiments demonstrated that ibogaine also interferes with motivational withdrawal reactions and somatic withdrawal reactions in rats treated with morphine on only two occasions. On each of two conditioning trials, naloxone was administered 24 h following an injection of morphine. Four hours prior to each naloxone administration, rats were injected with either ibogaine or saline. In two experiments, ibogaine interfered with naloxone-precipitated withdrawal. In Experiment 1, ibogaine-treated rats displayed a weaker aversion to the withdrawal-paired chamber, and in Experiment 2, ibogaine-treated rats displayed fewer somatic withdrawal reactions than did saline treated rats.
Parke
Linda A
LA
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada. lparker@wlu.ca
Burton
Page
P
McDonald
Robert V
RV
Kim
Joseph A
JA
Siegel
Shepard
S
D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D004334:Drug Administration Schedule; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D007050:Ibogaine / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009042:Motivation; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D018691:Excitatory Amino Acid Antagonists; D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D007050:Ibogaine; D009020:Morphine