Concentration of roxithromycin in the lesions of acne vulgaris.
Roxithromycin, a macrolide antibiotic, is used in the treatment of acne vulgaris, although there have been no reports on its concentration in lesions when administered orally. We investigated the concentration of roxithromycin in acne vulgaris lesions in five patients who received 150 mg roxithromycin orally twice daily for 2 weeks. The mean concentration of roxithromycin in the lesions was 0.54 microgram/ml. These results suggest that roxithromycin accumulates at therapeutic levels in the pilosebaceous system.
Akamatsu
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H
Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan. akamatsu@fujita-hu.ac.jp
Horio
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T
D000152:Acne Vulgaris / Q000188:drug therapy / Q000378:metabolism*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D015575:Roxithromycin / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D015575:Roxithromycin