[Tissue hypoxia, tumor angiogenesis and radiotherapy].
Biological effectiveness of low LET radiations is dependent on the partial oxygen pressure in the tissues at the time of energy deposit. Direct pO2 measurements demonstrate a low oxygen tension in tumours compared with surrounding normal tissues. Tumour hypoxia mediates response to treatment (radiotherapy and chemical modifiers), and modulates gene expression and angiogenesis, a key factor for metastases. The knowledge of these microenvironmental factors will allow new treatment strategies.
Lartigau
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Département de Radiothérapie, Centre Oscar Lambret, 3 rue Frédéric Combemale, 59000 Lille, France.
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D009369:Neoplasms / Q000098:blood supply* / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000532:radiotherapy*; D010101:Oxygen Consumption