A hemodialysis patient with trazodone-induced parkinsonism.
A hemodialysis male patient exhibited depressive symptoms and trazodone was prescribed orally. Although his depressive symptoms disappeared, he gradually presented with parkinsonism. His parkinsonism improved within a week after stopping trazodone. The clinical course strongly suggested that it was induced by trazodone. However, there is no report on antidopaminergic side effects of parkinsonism. This case suggests that antidopaminergic effects leading to parkinsonism need to be considered in patients on hemodialysis that are taking trazodone.
Fukunishi
Isao
I
Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan. fukunisi@prit.go.jp
Kitaoka
Tateki
T
Shirai
Tetsuo
T
Kino
Kyono
K
Kanematsu
Emiko
E
Sato
Yoshikazu
Y
D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000523:psychology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000139:chemically induced*; D006435:Renal Dialysis; D014196:Trazodone / Q000009:adverse effects*
D018687:Antidepressive Agents, Second-Generation; D014196:Trazodone