Calmodulin is a limiting factor in the cell.
The total intracellular concentration of calmodulin (CaM) in the cell appears to be significantly below the total concentration of its targets, making it a limiting factor in their regulation. In this review we discuss the ways in which this is likely to impact signaling. A key conclusion is that competition for a limiting pool of CaM enables cross-talk between CaM-dependent signaling pathways.
Persechini
Anthony
A
School of Biological Sciences, Division of Molecular Biology & Biochemistry, University of Missouri-Kansas City, Kansas City, MO 64110-2499, USA. persechinia@umkc.edu
Stemmer
Paul M
PM
D015374:Biosensing Techniques; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology*
D002147:Calmodulin; D002118:Calcium