Beta2-adrenergic receptor genetics.
The beta2-adrenergic receptor (beta2AR) is a positional candidate gene for asthma located on 5q31-33. There are 17 known polymorphisms in this gene. A determination of the functional significance of these polymorphisms is complicated by the lack of haplotypic assessment in most functional assays. The beta2AR gene is not an asthma-susceptibility gene but appears to be a minor determinant for lung function. The gene also has clear pharmacogenetic effects. Further work is needed to fully define the effects of haplotype on function, disease phenotype and pharmacogenetic effect.
Raby
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Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Restw@channing.harvard.edu
Weiss
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D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
D018343:Receptors, Adrenergic, beta-2