MAGUK SH3 domains--swapped and stranded by their kinases?
Excitement in protein science comes from unexpected structural findings that shed new light on functional mechanisms. Just such a series of insights is now beginning to emerge from two recently published structures of the scaffolding protein PSD-95.
Yaffe
Michael B
MB
Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
D051528:Guanylate Kinases; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism; D009703:Nucleoside-Phosphate Kinase / Q000737:chemistry* / Q000378:metabolism; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D018909:src Homology Domains
D009419:Nerve Tissue Proteins; C033652:postsynaptic density proteins; D009703:Nucleoside-Phosphate Kinase; D051528:Guanylate Kinases