title: [Cytostatic drug extravasation--are there new recommendations for therapeutic management?].
abstract: Extravasations are a matter of concern in cytostatic treatment. They may range from patients' discomfort up to severe complications such as necrosis and amputation. Cytotoxic drugs in general differ in a broad variety in their ability to induce severe cutaneous reactions and therefore the possible counter-measures vary. Though the compliance with regulations concerning the application and injection or infusion of cytotoxic substances can minimize the risk of inducing an extravasation, these basic safety procedures are reflected beside an overview of the literature concerning specific antidotes and procedures.
authors.affiliation: Medizinische Klinik IV, Schwerpunkt Hämatologie/Onkologie, Klinikum der Justus-Liebig-Universität, Klinikstrasse 36, D-35385 Giessen, Deutschland. klaus.fenchel@innere.med.uni-giessen.de
authors.forename: K
authors.initials: K
authors.lastname: Fenchel
authors.forename: M
authors.initials: M
authors.lastname: Karthaus
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000628:therapy; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology / Q000628:therapy*; D006801:Humans; D009336:Necrosis; D009369:Neoplasms / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents