Annonaceous acetogenins from the leaves of Annona montana.
A novel Annonaceous acetogenin, montanacin F, with a new type of terminal lactone unit, was isolated from the leaves of Annona montana. Its structure was determined on the basis of spectral evidences and chemical methods, and a possible biosynthetic pathway was discussed. In addition, the cytotoxicity of montanacin F was evaluated in vitro against Lewis lung carcinoma (LLC) tumor cell lines. Furthermore, the previously isolated cytotoxic acetogenin annonacin against LLC was examined for in vivo antitumor activity with LLC tumor cells.
Wang
Li-Quan
LQ
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.
Min
Byung-Sun
BS
Li
Yan
Y
Nakamura
Norio
N
Qin
Guo-Wei
GW
Li
Can-Jun
CJ
Hattori
Masao
M
D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D005260:Female; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000637:transplantation
D000970:Antineoplastic Agents; D005663:Furans; D007783:Lactones; C473415:montanacin F