Seven-transmembrane-spanning receptors and heart function.
Understanding precisely how the heart can recognize and respond to many different extracellular signalling molecules, such as neurotransmitters, hormones and growth factors, will aid the identification of new therapeutic targets through which cardiovascular diseases can be combated. In recent years, we have learned more about the complex interactions that occur between the receptors and the signalling pathways of the heart and its environment. Most of these discoveries have focused on the most common type of cardiac receptor - the seven-transmembrane-spanning receptor or G-protein-coupled receptor.
Rockman
Howard A
HA
Departments of Medicine and Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA. h.rockman@duke.edu
Koch
Walter J
WJ
Lefkowitz
Robert J
RJ
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004195:Disease Models, Animal; D019204:GTP-Binding Proteins / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D006801:Humans; D051379:Mice; D011487:Protein Conformation; D011941:Receptors, Adrenergic / Q000502:physiology; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology; D015398:Signal Transduction; D051552:beta-Adrenergic Receptor Kinases
D000319:Adrenergic beta-Antagonists; D011941:Receptors, Adrenergic; D011956:Receptors, Cell Surface; D011976:Receptors, Muscarinic; D017868:Cyclic AMP-Dependent Protein Kinases; D051552:beta-Adrenergic Receptor Kinases; D019204:GTP-Binding Proteins