[The relationship among proinsulin and true insulin to coronary artery disease].
OBJECTIVE
Whether proinsulin (PI) and true insulin (TI) are independently related to coronary artery disease (CAD).


METHODS
54 patients with CAD diagnosed by coronary angiography and/or intravascular ultrasound, 37 patients without CAD by coronary angiography and/or intravascular ultrasound and 23 healthy volunteers. All subjects had oral glucose tolerance test after an overnight 14 h fast. PI and TI concentrations were detected at different phases by BA-ELISA in which PI cross -reactivity is less than 0.1%.


RESULTS
Fasting and post-glucose loading PI and TI levels in both CAD and non-CAD groups significantly increased when compared with the control group (P < 0.05), after adjustment for age, body mass index and waist hip ratio, all statistically significant associations weakened or disappeared among three groups; but there was no significant difference of all the above variables between CAD group and non-CAD group (P > 0.05).


CONCLUSIONS
PI and TI, whether fasting or post-glucose loading, may not be independently related to CAD.
Zhu
Z
Z
Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, China.
Li
M
M
Chen
D
D
Zhang
K
K
Wu
C
C
Ji
B
B
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011384:Proinsulin / Q000097:blood*
D007328:Insulin; D011384:Proinsulin