On the detection of linkage in multiple data sets: a comparison of various statistical approaches.
We contrast the pooling of multiple data sets with the compound HLOD (HLOD-C) and the posterior probability of linkage (PPL), two approaches that have been shown to have more power in the presence of genetic heterogeneity. We also propose and evaluate several multipoint extensions.
Van Eerdewegh
P
P
Genome Therapeutics Corporation, 100 Beaver Street, Waltham, MA 02453, USA.
Dowd
M
M
Dupuis
J
J
Falls
K
K
Hayward
B
B
Santangelo
S L
SL
D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002878:Chromosomes, Human, Pair 1; D002889:Chromosomes, Human, Pair 2; D002896:Chromosomes, Human, Pair 6; D005260:Female; D018740:Genetic Heterogeneity; D005828:Genetics, Population; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D011336:Probability; D018709:Statistics, Nonparametric