title: Cluster of serogroup C meningococcal disease associated with attendance at a party.
abstract: BACKGROUND
  An unexplained increase has occurred in the incidence of invasive meningococcal disease in adolescents and young adults.
  
  
  METHODS
  We investigated a cluster of serogroup C meningococcal disease in 3 previously healthy young adults who had attended a party in Maryland. Molecular subtyping was done on the isolates from the 3 cluster cases and 4 control isolates by pulsed-field gel electrophoresis (PFGE). The only common exposure was attendance at the party, where a large number of people reportedly smoked tobacco or marijuana and/or drank alcohol.
  
  
  RESULTS
  The PFGE analysis of the 3 case isolates showed identical molecular subtypes.
  
  
  CONCLUSIONS
  This investigation strongly suggests that transmission of the cluster strain occurred at the party. Transmission may have occurred in part as a result of the recently described risk factors of binge drinking and smoking. Taken together, these findings suggest that some of the recent increase in invasive meningococcal disease may be due to modifiable risk factors.
authors.affiliation: Infectious Diseases Epidemiology Research Unit, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, 15261, USA.
authors.forename: R
authors.initials: R
authors.lastname: Finn
authors.forename: C
authors.initials: C
authors.lastname: Groves
authors.forename: M
authors.initials: M
authors.lastname: Coe
authors.forename: M
authors.initials: M
authors.lastname: Pass
authors.forename: L H
authors.initials: LH
authors.lastname: Harrison
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D017809:Fatal Outcome; D006801:Humans; D007899:Leisure Activities; D008297:Male; D008396:Maryland / Q000453:epidemiology; D008585:Meningitis, Meningococcal / Q000453:epidemiology*; D009345:Neisseria meningitidis / Q000235:genetics / Q000302:isolation & purification; D012307:Risk Factors; D012907:Smoking