title: [Collagen gastroenterocolitis].
abstract: BACKGROUND
  Collagenous gastroenterocolitis is a recently known rare cause of chronic diarrhoea, that raises numerous nosological and diagnostic problems.
  
  
  METHODS
  A 41 year-old woman was hospitalised for severe diarrhoea, diagnosed as collagenous gastroenterocolitis. Gastroscopy and ileocolonoscopy were macroscopically normal, but a 20 to 40 microns thick sub-epithelial collagenous band was revealed in the gastric, duodenal and colic biopsies. Parenteral nutrition and treatment with salazopyrine and prednisolone progressively normalised the transit. Three months later, only a 30 microns colic mucosa collagenous band persisted. All the biopsies taken during control gastro-colonoscopy 2 years later were histologically normal. After 5 years follow-up and absence of treatment, the patient no longer presented diarrhoea or biological abnormality.
  
  
  CONCLUSIONS
  This exceptional observation is a reminder that sub-epithelial collagen deposits are not always limited to the colon and therefore justify, in patients with collagenous colitis, systematic gastro-duodenal and ileum biopsies.
authors.affiliation: Service de Médecine Interne E, Hôpital Saint Eloi, 80 avenue Augustin Fliche, F34295 Montpellier.
authors.forename: M
authors.initials: M
authors.lastname: Melki
authors.forename: P
authors.initials: P
authors.lastname: Perney
authors.forename: A
authors.initials: A
authors.lastname: Vandome
authors.forename: V
authors.initials: V
authors.lastname: Roques
authors.forename: L
authors.initials: L
authors.lastname: Durand
authors.forename: Z
authors.initials: Z
authors.lastname: Joomaye
authors.forename: Y
authors.initials: Y
authors.lastname: Le Bricquir
authors.forename: I
authors.initials: I
authors.lastname: Parolini
authors.forename: P
authors.initials: P
authors.lastname: Beaufort
authors.forename: J F
authors.initials: JF
authors.lastname: Fléjou
authors.forename: F
authors.initials: F
authors.lastname: Blanc
mesh_terms: D000328:Adult; D001706:Biopsy; D003092:Colitis / Q000473:pathology*; D003094:Collagen / Q000378:metabolism*; D003967:Diarrhea / Q000209:etiology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000473:pathology; D005759:Gastroenteritis / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology
chemical_list: D003094:Collagen