[Experimental study of shuangcao granule no. 1 on duck hepatitis B virus in ducklings].
OBJECTIVE
To study the in vivo anti-viral effect of a Chinese drug, composite Shuangcao Anti-Jaundice Granule No. 1(SCG-1), on duck hepatitis B virus (DHBV).


METHODS
Guangzhou brown spot ducklings infected with DHBV were used as the hepatitis B animal model, for which, 1-day old ducklings were infected with DHBV. Positive DHBV-DNA in ducklings sera were detected 13 days after the infection, and then SCG-1 was given for 14 days and DHBV-DNA was detected by dot-blot hybridization test.


RESULTS
After medicated with SCG-1 [10 g/(kg.day) and 5 g/(kg.day)] 7 days and 14 days, optic density value (OD value) of DHBV-DNA in ducklings' sera were obviously lower than that before treatment, there was significant difference. But rebound phenomenon appeared in both groups 3 days after stopping medication (P < 0.05).


CONCLUSIONS
SCG-1 could inhibit the replication of DHBV-DNA in Guangzhou ducklings.
Lian
Y
Y
Guangzhou Municipal Eighth People's Hospital, Institute of Infectious Diseases, Guangzhou (510060).
Tan
J
J
Deng
Z
Z
D000818:Animals; D000831:Animals, Newborn; D000998:Antiviral Agents / Q000494:pharmacology*; D004279:DNA, Viral / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004372:Ducks; D018347:Hepadnaviridae Infections / Q000821:virology*; D004371:Hepatitis Virus, Duck / Q000187:drug effects*; D011897:Random Allocation
D000998:Antiviral Agents; D004279:DNA, Viral; D004365:Drugs, Chinese Herbal