Incorporating age at onset information into the transmission/disequilibrium test.
In this paper, we proposed two approaches for incorporating the age at onset into the transmission/disequilibrium test (TDT). Trios (affected offspring and their parents) were extracted from the first four replicate data sets of the general population type. Focusing on chromosome 6 where MG6 and MG7 reside, we compared the usual TDT with the newly proposed tests in terms of gene localization.
Hsu
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Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., N., MP-665, Seattle, WA 98109-1024, USA.
Prentice
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RL
Zhao
L P
LP
Li
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S
D000328:Adult; D000367:Age Factors; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data; D002896:Chromosomes, Human, Pair 6; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D019683:Penetrance
D005819:Genetic Markers