title: [Association between angiotensin-II receptor gene type I polymorphism and diabetic nephropathy in type 2 diabetes mellitus].
abstract: OBJECTIVE
  To investigate the relationship between angiotensin type I receptor (AGT I R) gene polymorphism and diabetic nephropathy (DN) and its progression.
  
  
  METHODS
  PCR technique was used to determine the AGT I R gene polymorphism in 86 patients without DN, 67 with microalbuminuria, 66 with clinical albuminuria and 20 type 2 DM patients with renal insufficiency.
  
  
  RESULTS
  In comparing the DN group with the non-DN group, it was found that there was a significant difference of the frequency of AC genotype with DN (chi(2) = 4.30, P < 0.05), and C mutative type was more frequent in the DN group (chi(2) = 3.97, P < 0.05). No significant difference of AGTIR-A1166-C genotype was found in cases with different durations of DN.
  
  
  CONCLUSIONS
  Delete polymorphism of A1166-C gene is associated with DN in type 2 diabetes mellitus. It is suggested that detection of significant AGTIR-A1166-C polymorphism is of help for preventing DN in type 2 diabetes mellitus.
authors.affiliation: Department of Endocrinology, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xue
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.forename: R
authors.initials: R
authors.lastname: Luo
authors.forename: M
authors.initials: M
authors.lastname: Guan
authors.forename: X
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000808:Angiotensinogen; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011945:Receptors, Angiotensin / Q000235:genetics*
chemical_list: D011945:Receptors, Angiotensin; D000808:Angiotensinogen