title: Duffy blood group genotypes among malaria patients in Rondônia, Western Brazilian Amazon.
abstract: We have compared Duffy blood group genotype distribution, as determined by polymerase chain reaction with allele-specific primers, in 68 Plasmodium vivax-infected patients and 59 non-vivax malaria controls from Rondônia, Brazil. Homozygosity for the allele Fy, which abolishes Duffy antigen expression on erythrocytes, was observed in 12% non-vivax controls but in no P. vivax patient. However, no significant association was found between Fy heterozygosity and protection against P. vivax. The Fy x allele, which has recently been associated with very weak erythrocyte expression of Duffy antigen, was not found in local P. vivax patients.
authors.affiliation: Laboratório de Parasitologia Molecular, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP.
authors.forename: C E
authors.initials: CE
authors.lastname: Cavasini
authors.forename: F J
authors.initials: FJ
authors.lastname: Tarelho Pereira
authors.forename: W L
authors.initials: WL
authors.lastname: Ribeiro
authors.forename: G
authors.initials: G
authors.lastname: Wunderlich
authors.forename: M U
authors.initials: MU
authors.lastname: Ferreira
mesh_terms: D001938:Brazil; D004375:Duffy Blood-Group System / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008288:Malaria / Q000235:genetics*
chemical_list: D004375:Duffy Blood-Group System