[Application of genetic diagnosis for colorectal cancer].
Recently, PCR techniques have been introduced for genetic diagnosis of colorectal cancer. The clinical significance of the genetic diagnosis of cancers includes preclinical diagnosis of hereditary cancers and viral tumors, prediction of malignancy and chemosensitivity focusing on expression profiling of related genes, and detection of micrometastasis in lymph node or bone marrow as well as of circulating tumor cells in peripheral blood targeting tumor-specific mRNA expression such as cytokeratin 19, 20 and CEA. In this report, molecular biological techniques for genetic diagnosis of colorectal cancer are discussed.
Shimada
M
M
Genetic Diagnosis Center, Takara Shuzo Co. Ltd., Kusatsu 525-0055.
D017209:Apoptosis / Q000235:genetics; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics; D016228:Endothelial Growth Factors / Q000235:genetics; D020869:Gene Expression Profiling; D018816:Genes, cdc; D005819:Genetic Markers; D006801:Humans; D008222:Lymphokines / Q000235:genetics; D009362:Neoplasm Metastasis / Q000175:diagnosis; D016133:Polymerase Chain Reaction; D013940:Thymidylate Synthase / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D005819:Genetic Markers; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013940:Thymidylate Synthase