[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.
The synthesis of a new potent, subtype-selective radioligand [(3)H]-M-MPEP (2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine) and its in vitro pharmacological characteristics are described. Science Ltd.
Gasparini
Fabrizio
F
Nervous System Research, Novartis Pharma AG, 4002 Basel, Switzerland. fabrizio.gasparini@pharma.novartis.com
Andres
Hendrik
H
Flor
Peter Josef
PJ
Heinrich
Micheline
M
Inderbitzin
Werner
W
Lingenhöhl
Kurt
K
Müller
Hanspeter
H
Munk
Veronica Cecilia
VC
Omilusik
Kyla
K
Stierlin
Christine
C
Stoehr
Natacha
N
Vranesic
Ivo
I
Kuhn
Rainer
R
D001665:Binding Sites; D001667:Binding, Competitive / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008024:Ligands; D011725:Pyridines / Q000494:pharmacology*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism
D008024:Ligands; D011725:Pyridines; D019275:Radiopharmaceuticals; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D011994:Recombinant Proteins; C120148:SIB 1893; C121465:6-methyl-2-(phenylethynyl)pyridine