ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling.
The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.
Gautreau
Alexis
A
UMR 144 CNRS/Institut Curie, 26 rue d'Ulm, 75248 Cedex 05, Paris, France.
Louvard
Daniel
D
Arpin
Monique
M
D008841:Actin Cytoskeleton / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D001798:Blood Proteins / Q000502:physiology; D002455:Cell Division; D003598:Cytoskeletal Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D008840:Microfilament Proteins / Q000502:physiology*; D008871:Microvilli / Q000648:ultrastructure; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology; D025581:Neurofibromin 2 / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology; D015398:Signal Transduction; D000099149:Ezrin
D000199:Actins; D001798:Blood Proteins; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D025581:Neurofibromin 2; D010750:Phosphoproteins; D000099149:Ezrin; C071058:moesin; C071776:radixin