title: Successful treatment of metastatic hormone-refractory prostate cancer with malignant pericardial tamponade using docetaxel.
abstract: Reports of malignant pericardial effusion due to adenocarcinoma of the prostate are few and describe only patients with hormone-naive disease. We report a case of malignant pleural and pericardial effusions due to metastatic hormone-refractory prostate cancer. Despite presenting with pericardial tamponade, this patient was successfully treated with pericardiocentesis and intrapericardial methylprednisolone and cisplatin, followed by a course of intravenous docetaxel. The patient was alive and free of disease-related symptoms nearly 2 years later. This case suggests that patients with pericardial tamponade due to hormone-refractory prostate cancer do not have a uniformly dismal prognosis and should be considered for aggressive treatment.
authors.affiliation: Oregon Health and Science University, Portland, Oregon 97201, USA.
authors.forename: Brandon M
authors.initials: BM
authors.lastname: Hayes-Lattin
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kovach
authors.forename: W David
authors.initials: WD
authors.lastname: Henner
authors.forename: Tomasz M
authors.initials: TM
authors.lastname: Beer
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000188:drug therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002305:Cardiac Tamponade / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D000077143:Docetaxel; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010490:Pericardial Effusion / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D020519:Pericardiocentesis; D010996:Pleural Effusion / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D011471:Prostatic Neoplasms / Q000150:complications* / Q000188:drug therapy; D043823:Taxoids
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel; D002945:Cisplatin; D008775:Methylprednisolone