Regulation of dendritic cell recruitment by chemokines.
Dendritic cells (DC) are a heterogeneous family of cells that function as sentinels of the immune system. This article summarizes observations suggesting that inflammatory chemokines secreted at the site of pathogen invasion determine the DC subset recruited and influence the class of the immune response initiated. Langerhans cells are selectively recruited by MIP-3alpha/CCL20. In contrast, CCR7 ligands have a key role in the accumulation of antigen-loaded mature DC in T cell-rich areas of the draining lymph node. Improved understanding of the regulation of DC trafficking might offer new opportunities for therapeutic interventions to control immune responses.
Caux
Christophe
C
Schering-Plough, Laboratory for Immunological Research, Dardilly, France. Christophe.Caux@spcorp.com
Vanbervliet
Béatrice
B
Massacrier
Catherine
C
Ait-Yahia
Smina
S
Vaure
Céline
C
Chemin
Karine
K
Dieu-Nosjean
Marie-Caroline
MC
Vicari
Alain
A
D000818:Animals; D000917:Antibody Formation; D002453:Cell Cycle; D016922:Cellular Senescence; D018925:Chemokines / Q000502:physiology*; D003713:Dendritic Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans
D018925:Chemokines