A mathematical model describing the glycemic response of diabetic patients to meal and i.v. infusion of insulin.
Nine type 1 diabetic patients were studied for 24 hours. During this period they were given three calibrated meals. The glycemia was feedback-controlled by means of an artificial pancreas. The blood concentration of glucose and the infusion speed of the insulin were measured every minute. The experimental data referring to each of the three meals were used to estimate the parameters of a mathematical model suitable for describing the glycemic response of diabetic patients at meals and at the i.v. infusion of exogenous insulin. From the estimate a marked dispersion of the parameters was found, both interindividual and intraindividual. Nevertheless the models thus obtained seem to be usable for the synthesis of a feedback controller, especially in view of creating a portable artificial pancreas that now seems possible owing to the realization (so far experimental) of sufficiently reliable glucose concentration sensors.
Fabietti
P G
PG
Department of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Italy.
Calabrese
G
G
Iorio
M
M
Bistoni
S
S
Brunetti
P
P
Sarti
E
E
Benedetti
M M
MM
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001786:Blood Glucose / Q000187:drug effects*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004435:Eating; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008962:Models, Theoretical
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin