Indole and beta-carboline alkaloids from Geissospermum sericeum.
The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.
Steele
Jonathan C P
JC
Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3DS, UK.
Veitch
Nigel C
NC
Kite
Geoffrey C
GC
Simmonds
Monique S J
MS
Warhurst
David C
DC
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D004351:Drug Resistance; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured / Q000187:drug effects
C449855:1,2-dehydrogeissoschizoline; D000962:Antimalarials; D002243:Carbolines; C449854:geissoschizoline N(4)-oxide; C410326:geissoschizine; D002738:Chloroquine; C034262:flavopereirine