Drosophila melanogaster FMRFamide-containing peptides: redundant or diverse functions?
FMRFamide-related peptides (FaRPs) are expressed throughout the animal kingdom and regulate a multitude of physiological activities. FaRPs have an RFamide C-terminal consensus structure that is important for interaction with the receptor. The ease of genetic manipulation and availability of genomic sequences makes Drosophila melanogaster an important experimental organism. Multiple classes of FaRPs encoded by different genes have been identified within this species. Here, we review FMRFamide-containing peptides encoded by the D. melanogaster FMRFamide gene in order to review the data on the expression, regulation, and activity of these peptides as well as acknowledge further endeavors required to elucidate FaRP signaling.
Merte
Janna
J
Department of Biological Chemistry, University of Michigan, Ann Arbor 48109-1048, USA.
Nichols
Ruthann
R
D000818:Animals; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism; D004331:Drosophila melanogaster; D019835:FMRFamide / Q000737:chemistry*; D007814:Larva / Q000378:metabolism; D010455:Peptides / Q000737:chemistry*; D015398:Signal Transduction; D013997:Time Factors
D010455:Peptides; D019835:FMRFamide