title: Hepatic progenitors and strategies for liver cell therapies.
abstract: Liver cell therapies, including liver cell transplantation and bioartificial livers, are being developed as alternatives to whole liver transplantation for some patients with severe liver dysfunction. Hepatic progenitors are proposed as ideal cells for use in these liver cell therapies given their ability to expand extensively, differentiate into all mature liver cells, have minimal immunogenicity, be cryopreservable, and reconstitute liver tissue when transplanted. We summarize our ongoing efforts to develop clinical programs of hepatic progenitor cell therapies with a focus on hepatic stem cell biology and strategies that have emerged in analyzing that biology.
authors.affiliation: Incara Cell Technologies, Research Triangle Park, North Carolina, USA.
authors.forename: R
authors.initials: R
authors.lastname: Susick
authors.forename: N
authors.initials: N
authors.lastname: Moss
authors.forename: H
authors.initials: H
authors.lastname: Kubota
authors.forename: E
authors.initials: E
authors.lastname: Lecluyse
authors.forename: G
authors.initials: G
authors.lastname: Hamilton
authors.forename: T
authors.initials: T
authors.lastname: Luntz
authors.forename: J
authors.initials: J
authors.lastname: Ludlow
authors.forename: J
authors.initials: J
authors.lastname: Fair
authors.forename: D
authors.initials: D
authors.lastname: Gerber
authors.forename: K
authors.initials: K
authors.lastname: Bergstrand
authors.forename: J
authors.initials: J
authors.lastname: White
authors.forename: A
authors.initials: A
authors.lastname: Bruce
authors.forename: O
authors.initials: O
authors.lastname: Drury
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: L M
authors.initials: LM
authors.lastname: Reid
mesh_terms: D000818:Animals; D019070:Cell Lineage; D015925:Cryopreservation; D018380:Hematopoietic Stem Cell Transplantation; D022781:Hepatocytes / Q000166:cytology / Q000637:transplantation*; D006801:Humans; D008115:Liver Regeneration; D012377:Rodentia