[Effect of inverse ratio ventilation on hemodynamics and oxygen metabolism in sheep with acute respiratory distress syndrome].
OBJECTIVE
To observe the effect of inverse ratio ventilation (IRV) on hemodynamics and oxygen metabolism in sheep with acute respiratory distress syndrome (ARDS).


METHODS
Twelve ARDS sheep induced by LPS were admitted to this study, and received mechanical ventilation with volume controlled (VC) and pressure controlled ventilation (PC) (conventional ratio and inverse ratio) at the same level of total positive end expiratory pressure (PEEPt), data of hemodynamics and oxygen metabolism were collected at 30 min after the onset of each mode.


RESULTS
With PC, peak airway pressure was lower than that with VC, but mean airway pressure was higher with IRV. At the same level of PEEPt, there was no difference in hemodynamics and oxygen metabolism between VC and VC-IRV, same as PC and PC-IRV. But compared with VC, arterial oxygen pressure and arterial oxygen saturation with PC-IRV were lower significantly (P < 0.05).


CONCLUSIONS
PEEPt was a very important factor to improve oxygenation, short-term IRV was not better than VC or PC.
Yang
Y
Y
ICU of Zhongda Hospital, Southeast University, Nanjing 210009, China.
Qiu
H
H
Guo
F
F
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D006439:Hemodynamics; D010100:Oxygen / Q000378:metabolism*; D012123:Pulmonary Ventilation; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000503:physiopathology*; D012756:Sheep
D010100:Oxygen