Genotype and allele frequency of the 27-bp tandem repeat polymorphism in the endothelial nitric oxide synthase gene in Chinese population.
Genotype and allele frequency of the polymorphic 27-bp repeat, a variable number of tandem repeats (VNTR) located in intron 4 of the endothelial nitric oxide synthase gene, were analyzed in 316 healthy Chinese individuals. Four genotypes, namely 6/5-repeats heterozygous, 5/5-repeats homozygous, 5/4-repeats heterozygous and 4/4-repeats homozygous, were identified. Both observed genotype and allele frequencies of this VNTR in Chinese were similar to those of Japanese, while the 4/4-repeats genotype differed significantly from that of Caucasians in Spain, and all ones did from those of African-American in United States.
Lu
P
P
Department of Biochemistry & Molecular Biology, Institute of Radiation Medicine, Military Medical College, Beijing, China.
Lü
X
X
Xing
R Y
RY
Sun
Q Y
QY
Han
L
L
Wu
S H
SH
Lan
H
H
Zheng
X F
XF
D000483:Alleles; D001483:Base Sequence; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences
C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III