title: Efficacy of topically applied glutamate-aspartate and pentoxifylline solutions in decreasing myocardial damage during open-heart surgery in rats.
abstract: During open-heart surgery, the period between cross-clamping and maintenance of homogeneous diastolic arrest is often accompanied by significant ischaemic-hypoxic injury. The topical application of glutamate-aspartate or pentoxifylline may reduce energy demands during this period and thus prevent myocardial damage. Fifty rats were divided into five groups. In group A (control) the pericardial cavity was opened, all inlet and outlet vasculature cross-clamped, and the heart excised after 60 s. In groups B-E, the pericardial cavity was opened, all inlet and outlet vasculature cross-clamped for 60 s (groups B and D) or 90 s (groups C and E), and the pericardial cavity filled with glutamate-aspartate solution (groups B and C) or pentoxifylline solution (groups D and E) for 2 min. Following clamping, blood was withdrawn from the right atrium for biochemical analysis, and the heart excised for histological analysis. Histopathological and biochemical analysis showed a significant reduction in ischaemic-hypoxic cardiac injury in rats treated with topically applied glutamate-aspartate or pentoxifylline.
authors.affiliation: Department of Cardiovascular Surgery, GATA Haydarpaşa Training Hospital, Istanbul, Turkey.
authors.forename: M H
authors.initials: MH
authors.lastname: Us
authors.forename: S
authors.initials: S
authors.lastname: Ozkan
authors.forename: T
authors.initials: T
authors.lastname: Oğuş
authors.forename: H V
authors.initials: HV
authors.lastname: Acar
authors.forename: T
authors.initials: T
authors.lastname: Ege
authors.forename: O
authors.initials: O
authors.lastname: Cakir
authors.forename: M
authors.initials: M
authors.lastname: Gökben
authors.forename: O Y
authors.initials: OY
authors.lastname: Oztürk
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage*; D018698:Glutamic Acid / Q000008:administration & dosage*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D010431:Pentoxifylline / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D019616:Thoracic Surgical Procedures
chemical_list: D012996:Solutions; D001224:Aspartic Acid; D018698:Glutamic Acid; D010431:Pentoxifylline