[Quantitative assessment of beta-cell ultrastructure from mono- and polyhormonal insulinomas].
Surgical biopsies from 21 patients with syndrome of organic hyperinsulinism were studied. Precise quantitative characteristics of "typical" and "atypical" beta-granules in tumor cells were obtained by means of quantitative and qualitative analysis. The criteria for establishing the tumor type (mono- or polyhormonal) and the degree of hormonal activity are established. The validity of these criteria is confirmed by positive correlation between the secretory activity of the tumor and insulin level in the patient's blood.
Borodataia
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M.F. Vladimirsky Moscow Region Research Clinical Institute, 129110, Moscow.
Morozov
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Gurevich
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D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007340:Insulinoma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D007515:Islets of Langerhans / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*
D007328:Insulin