Misoprostol for women's health: a review.
OBJECTIVE
To review published literature on misoprostol for women's health indications to provide a synthesis of available information and highlight areas in need of additional research.


METHODS
Studies were identified through searches of medical literature databases including MEDLINE, Cochrane Database, and Popline, in addition to a review of references from identified articles.


METHODS
We included all studies reported in English and published before March 31, 2001, which evaluated the efficacy of misoprostol alone for labor and delivery, evacuation of the uterus after pregnancy failure and induced abortion. Studies were not excluded based on quality or sample size.


RESULTS
Misoprostol shows promise for all of the women's health indications addressed. Currently available data, though, are often hard to interpret because of variations in regimen, dose, and outcome measures. The low cost, ease of administration and storage, and widespread availability of misoprostol make it particularly appealing for developing countries. Because many of the women's health problems for which misoprostol could be prescribed currently cause significant mortality and morbidity, increased access to and information on use of misoprostol could help improve women's health especially where these problems are most severe.


CONCLUSIONS
Further research is needed to identify optimal regimens for misoprostol for obstetric and gynecologic health indications. Registering misoprostol with national drug regulatory authorities for any of several women's health indications could help increase access to and safe use of this drug. Provider training would be a logical subsequent step.
Blanchard
Kelly
K
Population Council, Johannesburg, South Africa. kblanchard@pcjoburg.org.za
Clark
Shelley
S
Winikoff
Beverly
B
Gaines
Gayle
G
Kabani
Ghazala
G
Shannon
Caitlin
C
D000019:Abortifacient Agents / Q000627:therapeutic use*; D000028:Abortion, Induced; D020070:Cervical Ripening; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use*; D010120:Oxytocics / Q000627:therapeutic use*; D011247:Pregnancy; D016387:Women's Health
D000019:Abortifacient Agents; D010120:Oxytocics; D016595:Misoprostol