[Effect of ligustrazine injection on vascular endothelial cell of the patients with arteriosclerosis obliterans].
OBJECTIVE
To study the effect of ligustrazine injection (LI) on vascular endothelial cell of the patients with arteriosclerosis obliterans (ASO) and explore the new pathway of investigating effective vascular protective agents in Chinese medicinal herbs.


METHODS
Forty-six patients with ASO in the LI group treated by LI were observed, their circulating endothelial cells (CEC) were detected quantitatively before and after treatment. The results were compared with the CEC of 53 cases of healthy persons (control group) in the same period.


RESULTS
In the LI group, the immediate cure rate was 45.7% (21 cases), markedly effective rate 36.9% (17 cases) and the effective rate 17.4% (8 cases). The CEC of patients before treatment was 4.39 +/- 1.76/0.9 microliter, which was significantly higher than that of the healthy persons (1.53 +/- 0.42/0.9 microliter). It could be reduced after treatment, along with the improvement of symptoms and signs, to 2.43 +/- 0.87/0.9 microliter, P < 0.01.


CONCLUSIONS
LI in treating ASO not only displays extraordinary effect, but also has good effect in curing the damage of endothelial cells.
Li
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S
Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin (300020).
Huang
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P
Liu
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C
D000368:Aged; D000369:Aged, 80 and over; D001162:Arteriosclerosis Obliterans / Q000188:drug therapy* / Q000473:pathology; D002452:Cell Count; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011719:Pyrazines / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D011719:Pyrazines; C017953:tetramethylpyrazine