title: Distribution of lod scores in oligogenic linkage analysis.
abstract: In variance component oligogenic linkage analysis it can happen that the residual additive genetic variance bounds to zero when estimating the effect of the ith quantitative trait locus. Using quantitative trait Q1 from the Genetic Analysis Workshop 12 simulated general population data, we compare the observed lod scores from oligogenic linkage analysis with the empirical lod score distribution under a null model of no linkage. We find that zero residual additive genetic variance in the null model alters the usual distribution of the likelihood-ratio statistic.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Williams
authors.forename: K E
authors.initials: KE
authors.lastname: North
authors.forename: L J
authors.initials: LJ
authors.lastname: Martin
authors.forename: A G
authors.initials: AG
authors.lastname: Comuzzie
authors.forename: H H
authors.initials: HH
authors.lastname: Göring
authors.forename: J
authors.initials: J
authors.lastname: Blangero
mesh_terms: D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002881:Chromosomes, Human, Pair 12; D002888:Chromosomes, Human, Pair 19; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008432:Mathematical Computing; D008957:Models, Genetic; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D012984:Software