title: The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen.
abstract: Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (6,7,10). While the vast majority of tumor cells from these malignancies are latently infected, only a small subset of viral genes are actually expressed (5,40,47). Of these genes, the latency-associated nuclear antigen (LANA-1, LNA, or LNA1) is the only protein consistently shown to be highly expressed by in situ hybridization and immunohistochemistry (11,20,21,32). Moreover, within the past few years LANA-1 has proven to be a quite versatile protein, playing not only a pivotal role in KSHV episome persistence, but also in interacting with and influencing several cellular genes.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: T
authors.initials: T
authors.lastname: Komatsu
authors.forename: A J
authors.initials: AJ
authors.lastname: Barbera
authors.forename: M E
authors.initials: ME
authors.lastname: Ballestas
authors.forename: K M
authors.initials: KM
authors.lastname: Kaye
mesh_terms: D000818:Animals; D000956:Antigens, Viral; D019288:Herpesvirus 8, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000096:biosynthesis*; D012514:Sarcoma, Kaposi / Q000821:virology*; D017735:Virus Latency
chemical_list: D000956:Antigens, Viral; D009687:Nuclear Proteins; C109540:latency-associated nuclear antigen