[Inhibitory effect of panicoin on platelet activation and its mechanism].
OBJECTIVE
To explore the inhibitory pathway and the possible mechanism of panicoin on platelet activation.


METHODS
The effect of panicoin on platelet aggregation, thromboxane B2 release, P-selectin (GMP-140) count, levels of cyclic AMP and cyclic GMP induced by ADP, epinephrine, arachidonic acid (AA) or thrombin were observed.


RESULTS
(1) Panicoin significantly inhibits platelet aggregation induced by ADP, arachidonic acid and epinephrine in a dose-dependent manner; (2) It reduces the P-selectin number on platelet surface which was stimulated by thrombin; (3) It inhibits TXB2 release induced by AA and increases the platelet cyclic AMP level, while cyclic GMP level was not changed.


CONCLUSIONS
Panicoin shows a potent inhibition on platelet activation and antithrombotic effect. The mechanisms seem to be related with the elevation of platelet cyclic AMP.
Han
G
G
Xuzhou Geriatrics Institute, Jiangsu (221003).
Yao
Q
Q
Li
H
H
D001792:Blood Platelets / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D019007:P-Selectin / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D019007:P-Selectin; D010975:Platelet Aggregation Inhibitors; D013929:Thromboxane B2; D000242:Cyclic AMP