[Influence of safflower injection on hemorheology of patients of chronic cor pulmonale during acute attack].
OBJECTIVE
To study the effect of safflower injection (SI) on hemorheology and fibrinolytic system in treating patients of chronic cor pulmonale during acute attack.


METHODS
Sixty patients were divided into two groups, 30 in each group. Both groups were treated with conventional therapy including anti-inflammatory, relieving cough and reducing sputum, cardial, diuretic and continuous low-flow oxygen inhalation. For the SI group, additional two courses of SI injection was given intravenously for 10 days as one course with an interval of 5 days between courses. The clinical therapeutic effect in the two groups and effect of treatment on hemorheology and fibrinolytic function were observed.


RESULTS
The total effective rate in the SI group was 86.7% and that in the control group was 63.3%, the difference between the two groups was significant (P < 0.05). After treatment, in the SI group, the high- and low-shear whole blood viscosity, plasma viscosity, erythrocyte agglutination index, hematocrit and fibrinogen lowered obviously, as compared with before treatment (P < 0.01 or P < 0.05), and the improvement in hemorrheologic property was better than that in the control group significantly (P < 0.05). The blood activities of anti-thrombin III, plasminogen and tectotype profibrinolytic activating factor were all higher than those in the control group (P < 0.05, P < 0.01). And SI showed more potent effect in improving anti-coagulation and fibrinolytic function of patients than that of the control (P < 0.05).


CONCLUSIONS
SI is an effective drug for treatment of hypercoagulability status in acute stage of chronic cor pulmonale, and is worthy of clinical application.
Jin
Y
Y
Xinhua Hospital, Shanghai Second Medical University, Shanghai (200092).
Xu
D
D
Xu
W
W
D000368:Aged; D000369:Aged, 80 and over; D002599:Chalcone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D018056:Hemorheology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011660:Pulmonary Heart Disease / Q000097:blood / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; C076422:safflower yellow; D002599:Chalcone