title: Gynaecomastia with hypergonadotrophic hypogonadism and Leydig cell insufficiency in recipients of high-dose chemotherapy or chemo-radiotherapy.
abstract: Late side-effects of stem cell transplantation include hypogonadism with infertility and sexual dysfunction, but gynaecomastia is less well recognised. We report five cases of gynaecomastia with features of hypergonadotrophic hypogonadism (primary testicular failure), who received either a TBI/cyclophosphamide conditioned allograft (n = 3) or a BEAM autograft (n = 2). Patients receiving an allograft had gynaecomastia, Leydig cell insufficiency (LCI) diminished libido and erectile dysfunction. Surgery was required in one case, while in two cases the gynaecomastia resolved spontaneously after 6 months. Two patients also had gynaecomastia and sexual dysfunction, severe hypogonadism, very low testosterone levels and marked hyperprolactinaemia following autoBMT. Both responded well to testosterone replacement therapy (TRT). As a group, all patients had primary testicular failure and all except one, had LCI (compensated or frank). However, there was no correlation between the severity of gynaecomastia and the degree of endocrine dysfunction. This preliminary study is the first to suggest that gynaecomastia, due to primary hypogonadism and LCI, may be a significant complication of myeloablative conditioning therapy. Therefore gynaecomastia in BMT recipients must always be treated as a pathological entity as it may be the external manifestation of a complex endocrine pathology. It is a potentially treatable condition. Although spontaneously reversible, some patients may require TRT or even surgery. We recommend comprehensive endocrine testing in conjunction with a reproductive endocrinologist and prompt intervention to alleviate embarrassment and anxiety in afflicted BMT recipients.
authors.affiliation: BMTU, Queen Elizabeth Hospital, Birmingham, UK.
authors.forename: E
authors.initials: E
authors.lastname: Harris
authors.forename: P
authors.initials: P
authors.lastname: Mahendra
authors.forename: H H
authors.initials: HH
authors.lastname: McGarrigle
authors.forename: D C
authors.initials: DC
authors.lastname: Linch
authors.forename: R
authors.initials: R
authors.lastname: Chatterjee
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003687:Dehydroepiandrosterone / Q000097:blood; D006062:Gonadotropins / Q000097:blood*; D006177:Gynecomastia / Q000209:etiology* / Q000628:therapy; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000209:etiology*; D007985:Leydig Cells / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D006062:Gonadotropins; D003687:Dehydroepiandrosterone