[Hormone replacement therapy reduces the risk of forearm fracture in postmenopausal women. Results of the Danish Osteoporosis Prevention Study].
In a prospective, controlled, comprehensive cohort trial of 2,016 healthy early postmenopausal women aged 45-58 years we studied fracture prevention through the use of oestrogen. There were two main study arms: a randomised arm (randomised to HRT [n = 502] or not [n = 504]) and a non-randomised arm (on HRT [n = 221] or not [n = 789] by own choice). After five years, an intention-to-treat analysis (n = 2,016) showed a reduction in the overall fracture risk (RR = 0.73, 95% CI: 0.50-1.05) and in the forearm fracture risk (RR = 0.45, 95% CI: 0.22-0.90) with oestrogen. Restriction of the analysis to women who had adhered to their initial allocation of either oestrogen (n = 395) or no oestrogen (n = 977) showed a significant reduction in both the overall fracture risk (RR = 0.61, 95% CI: 0.39-0.97) and the risk of forearm fractures (RR = 0.24, 95% CI: 0.09-0.69). We conclude that it is possible to reduce the number of forearm fractures in early postmenopausal women by the use of oestrogen as primary prevention.
Mosekilde
L
L
Medicinsk afdeling C, Arhus Universitetshospital, Arhus Amtssygehus.
Beck-Nielsen
H
H
Sørensen
O H
OH
Nielsen
S P
SP
Charles
P
P
Vestergaard
P
P
Hermann
A P
AP
Gram
J
J
Hansen
T B
TB
Abrahamsen
B
B
Ebbesen
E N
EN
Stilgren
L S
LS
Jensen
L B
LB
Brot
C
C
Hansen
B
B
Tofteng
C L
CL
Eiken
P A
PA
Kolthoff
N U
NU
D000368:Aged; D015519:Bone Density; D015331:Cohort Studies; D015914:Estrogen Replacement Therapy; D005260:Female; D005543:Forearm Injuries / Q000209:etiology / Q000517:prevention & control*; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies