Theopederins K and L. Highly potent cytotoxic metabolites from a marine sponge Discodermia species.
Theopederins K (1) and L (2) have been isolated from the marine sponge Discodermia sp. collected from Honduras. 1 and 2 showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation, biological activities, and structure elucidation of theopederins K (1) and L (2) are described.
Paul
Gopal K
GK
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, Florida 34946, USA.
Gunasekera
Sarath P
SP
Longley
Ross E
RE
Pomponi
Shirley A
SA
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006721:Honduras; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D008175:Lung Neoplasms; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D011714:Pyrans; C449841:theopederin K; C449842:theopederin L