Angiogenesis and hereditary hemorrhagic telangiectasia. Rendu-Osler-Weber disease.
To date much of the recent work on pathological angiogenesis has focused on inflammatory diseases, diabetes and cancer in particular. Hereditary hemorrhagic telangiectasia or Rendu-Osler-Weber disease provides an example of the genetic disorder of angiogenesis in which a multisystemic angiodysplasia is responsible for severe hemorrhage. The disease pathogenesis is partially explained by a defect in the TGF-beta signaling system, although in more recent works a possible role of other vascular growth factors has been proposed. This paper provides a model of an aberrant angiogenesis in which multiple vascular growth factors could be involved in a diffuse angiodysplasia.
Sabbà
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C
Cattedra di Medicina d'Urgenza e Pronto Soccorso, Università degli Studi, Bari, Italy.
Cirulli
A
A
Rizzi
R
R
Pasculli
G
G
Gallitelli
M
M
Specchia
G
G
Liso
V
V
D030201:Activin Receptors, Type I / Q000235:genetics / Q000502:physiology; D030301:Activin Receptors, Type II; D000818:Animals; D015703:Antigens, CD; D000071063:Endoglin; D016228:Endothelial Growth Factors / Q000378:metabolism / Q000502:physiology; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D008222:Lymphokines / Q000378:metabolism / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000235:genetics*; D011956:Receptors, Cell Surface; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000209:etiology* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000502:physiology; D019010:Vascular Cell Adhesion Molecule-1 / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D016228:Endothelial Growth Factors; D006133:Growth Substances; D008222:Lymphokines; D011956:Receptors, Cell Surface; D016212:Transforming Growth Factor beta; D019010:Vascular Cell Adhesion Molecule-1; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C425364:ACVRL1 protein, human; D030201:Activin Receptors, Type I; D030301:Activin Receptors, Type II