[Association between angiotensin-II receptor gene type I polymorphism and diabetic nephropathy in type 2 diabetes mellitus].
OBJECTIVE
To investigate the relationship between angiotensin type I receptor (AGT I R) gene polymorphism and diabetic nephropathy (DN) and its progression.


METHODS
PCR technique was used to determine the AGT I R gene polymorphism in 86 patients without DN, 67 with microalbuminuria, 66 with clinical albuminuria and 20 type 2 DM patients with renal insufficiency.


RESULTS
In comparing the DN group with the non-DN group, it was found that there was a significant difference of the frequency of AC genotype with DN (chi(2) = 4.30, P < 0.05), and C mutative type was more frequent in the DN group (chi(2) = 3.97, P < 0.05). No significant difference of AGTIR-A1166-C genotype was found in cases with different durations of DN.


CONCLUSIONS
Delete polymorphism of A1166-C gene is associated with DN in type 2 diabetes mellitus. It is suggested that detection of significant AGTIR-A1166-C polymorphism is of help for preventing DN in type 2 diabetes mellitus.
Xue
Y
Y
Department of Endocrinology, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China.
Cheng
Y
Y
Zhou
L
L
Luo
R
R
Guan
M
M
Zhang
X
X
D000328:Adult; D000368:Aged; D000808:Angiotensinogen; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011945:Receptors, Angiotensin / Q000235:genetics*
D011945:Receptors, Angiotensin; D000808:Angiotensinogen