Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin.
The first example of dual inhibitors for matrix metalloproteinase (MMP) and cathepsin is described. An appropriate alignment of peptide-parts and two different specific functional groups in one molecule led to the discovery of a potent dual inhibitor (3a).
Yamamoto
Minoru
M
Chemistry Group R&D Laboratories, Nippon Organon K.K., 1-5-90 Tomobuchi-Cho, Miyakojima-Ku, Osaka, Japan.
Ikeda
Shoji
S
Kondo
Hirosato
H
Inoue
Shintaro
S
D056668:Cathepsin L; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D003546:Cysteine Endopeptidases; D015195:Drug Design; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D010455:Peptides; D015842:Serine Proteinase Inhibitors; D002403:Cathepsins; D003546:Cysteine Endopeptidases; D056668:Cathepsin L