title: Incorporating age at onset information into the transmission/disequilibrium test.
abstract: In this paper, we proposed two approaches for incorporating the age at onset into the transmission/disequilibrium test (TDT). Trios (affected offspring and their parents) were extracted from the first four replicate data sets of the general population type. Focusing on chromosome 6 where MG6 and MG7 reside, we compared the usual TDT with the newly proposed tests in terms of gene localization.
authors.affiliation: Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., N., MP-665, Seattle, WA 98109-1024, USA.
authors.forename: L
authors.initials: L
authors.lastname: Hsu
authors.forename: R L
authors.initials: RL
authors.lastname: Prentice
authors.forename: L P
authors.initials: LP
authors.lastname: Zhao
authors.forename: S
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data; D002896:Chromosomes, Human, Pair 6; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D019683:Penetrance
chemical_list: D005819:Genetic Markers