Intraoperative metabolic monitoring of the heart: I. Clinical assessment of coronary sinus metabolites.
Numerous clinical studies have corroborated the ability of intraoperative sampling of coronary sinus blood to measure changes in myocardial metabolism induced by ischemia and reperfusion. Among other changes, cardiac arrest induces a period of obligate myocardial lactate production that persists for an indeterminate amount of time after reperfusion. Coronary sinus lactate assays have been established as a standard method to compare various myocardial protection strategies. Current methodology requires detailed sample processing, precluding real-time feedback in the operating room. Newer devices hold promise in allowing the online assessment of myocardial metabolism; however, these methods await precise validation.
Crittenden
M D
MD
Department of Surgery, VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical School, Massachusetts, USA. michael.crittenden@med.va.gov
D004734:Energy Metabolism / Q000502:physiology*; D006324:Heart Arrest, Induced; D006331:Heart Diseases / Q000097:blood / Q000601:surgery*; D006801:Humans; D007431:Intraoperative Complications / Q000097:blood / Q000175:diagnosis*; D019344:Lactic Acid / Q000097:blood*; D016343:Monitoring, Intraoperative; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis*; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000175:diagnosis*
D019344:Lactic Acid