The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells.
Immunoglobulin A (IgA) provides protection against pathogens at mucosal surfaces. Chemotactic responses have been hypothesized to target IgA plasma cells involved in mucosal immune responses. We show here that thymus-expressed chemokine (TECK, CCL25) is a potent and selective chemoattractant for IgA antibody-secreting cells (ASC), efficiently recruiting IgA-producing cells from spleen, Peyer's patches, and mesenteric lymph node. Cells secreting IgA antibody in response to rotavirus, an intestinal pathogen, also respond well. In contrast, IgG- and IgM-ASC respond poorly. Epithelial cells in the small intestines, a principal site of IgA-ASC localization and IgA production in the body, highly and selectively express TECK. The migration of IgA-ASC to the intestinal epithelial cell chemokine TECK may help target IgA-producing cells to the gut wall, thus helping define and segregate the intestinal immune response.
Bowman
Edward P
EP
Laboratory of Immunology and Vascular Biology, Department of Pathology and the Digestive Disease Center, Stanford University Medical School, Stanford, CA 94305-8444, USA.
Kuklin
Nelly A
NA
Youngman
Kenneth R
KR
Lazarus
Nicole H
NH
Kunkel
Eric J
EJ
Pan
Junliang
J
Greenberg
Harry B
HB
Butcher
Eugene C
EC
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D019742:Chemokines, CC / Q000276:immunology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D005260:Female; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology
C491541:Ccl25 protein, mouse; D019742:Chemokines, CC; D007070:Immunoglobulin A