title: Standardized uptake value in pediatric patients: an investigation to determine the optimum measurement parameter.
abstract: Although the standardized uptake value (SUV) is currently used in fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging, concerns have been raised over its accuracy and clinical relevance. Dependence of the SUV on body weight has been observed in adults and this should be of concern in the pediatric population, since there are significant body changes during childhood. The aim of the present study was to compare SUV measurements based on body weight, body surface area and lean body mass in the pediatric population and to determine a more reliable parameter across all ages. Sixty-eight pediatric FDG-PET studies were evaluated. Age ranged from 2 to 17 years and weight from 11 to 77 kg. Regions of interest were drawn at the liver for physiologic comparison and at FDG-avid malignant lesions. SUV based on body weight (SUV(bw)) varied across different weights, a phenomenon less evident when body surface area (SUV(bsa)) normalization is applied. Lean body mass-based SUV (SUV(lbm)) also showed a positive correlation with weight, which again was less evident when normalized to bsa (SUV(bsa-lbm)). The measured liver SUV(bw) was 1.1+/-0.3, a much lower value than in our adult population (1.9+/-0.3). The liver SUV(bsa) was 7.3+/-1.3. The tumor sites had an SUV(bw) of 4.0+/-2.7 and an SUV(bsa) of 25.9+/-15.4 (65% of the patients had neuroblastoma). The bsa-based SUVs were more constant across the pediatric ages and were less dependent on body weight than the SUV(bw). These results indicate that SUV calculated on the basis of body surface area is a more uniform parameter than SUV based on body weight in pediatric patients and is probably the most appropriate approach for the follow-up of these patients.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York City, NY 10021, USA. yeungh@mskcc.org
authors.forename: H W
authors.initials: HW
authors.lastname: Yeung
authors.forename: A
authors.initials: A
authors.lastname: Sanches
authors.forename: O D
authors.initials: OD
authors.lastname: Squire
authors.forename: H A
authors.initials: HA
authors.lastname: Macapinlac
authors.forename: S M
authors.initials: SM
authors.lastname: Larson
authors.forename: Y E
authors.initials: YE
authors.lastname: Erdi
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001830:Body Surface Area; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014055:Tomography, Emission-Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18