title: Cytotoxic triterpenoides from Alismatis Rhizoma.
abstract: Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation using in vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with ED50 values of 7.5, 7.5, 4.9 microg/ml, respectively.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Taejon.
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: Y
authors.initials: Y
authors.lastname: Kho
authors.forename: B
authors.initials: B
authors.lastname: Min
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Na
authors.forename: S
authors.initials: S
authors.lastname: Kang
authors.forename: H
authors.initials: H
authors.lastname: Maeng
authors.forename: K
authors.initials: K
authors.lastname: Bae
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002783:Cholestenones / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002783:Cholestenones; C457233:alisol A 24-acetate; C401295:alisol B monoacetate; C457234:alisol C 23-acetate; C457232:alisol B