Population based linkage disequilibrium mapping of QTL: an application to simulated data in an isolated population.
Despite successes in mapping and cloning genes involved in rare Mendelian diseases, genetic dissection of quantitative traits into single Mendelian factors still remains a challenging task. As the dense map of single nucleotide polymorphism (SNP) markers becomes available in the near future, linkage disequilibrium (LD) mapping will become one of major tools for mapping and identifying quantitative trait loci (QTL). In this report, we present a population-based linkage disequilibrium mapping of QTL. This method unifies the analysis of mapping QTL in humans and in model organisms and can be used for randomly sampled individuals. The proposed method is applied to search for polymorphism sites within the candidate genes 2 and 6, which influence quantitative traits Q1 and Q2 or Q5, in a simulated data set in an isolated population.
Zhao
J
J
Human Genetics Center, University of Texas-Houston, Houston, Texas, USA.
Li
W
W
Xiong
M
M
D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008957:Models, Genetic; D010641:Phenotype; D019655:Quantitative Trait, Heritable
D005819:Genetic Markers