Effects of intracranial injection of transforming growth factor-beta relevant to central fatigue on the waking electroencephalogram of rats: comparison with effects of exercise.
To investigate the detailed actions of transforming growth factor-beta (TGF-beta) in the brain, which increase accompanied with continuity of exercise, the authors performed electroencephalogram (EEG) spectral analysis for 2 h after intracranial injection of TGF-beta in rats and compared with the effects of swimming exercise. Relative power values (power percent) of the theta frequency band (4-7 Hz) increased and power percent of the alpha frequency band (7-13 Hz) decreased after intracranial injection of TGF-beta. The directions of these changes of EEG after intracranial injection of TGF-beta were consistent with those after exercise. The EEG pattern produced by leucine-enkephalin (Leu-enk), a typical brain peptide related to exercise, was completely different from that after exercise. The results suggested that the increase in TGF-beta concentration in the brain is, at least partly, relevant to the change of neuronal activity after exercise.
Arai
Masanao
M
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.
Yamazaki
Hanae
H
Inoue
Kazuo
K
Fushiki
Tohru
T
D000818:Animals; D004569:Electroencephalography / Q000187:drug effects* / Q000706:statistics & numerical data; D005221:Fatigue / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016212:Transforming Growth Factor beta / Q000494:pharmacology / Q000502:physiology*
D016212:Transforming Growth Factor beta