title: Alterations in monitored vital constants induced by various local anesthetics in combination with different vasoconstrictors in the surgical removal of lower third molars.
abstract: The purpose of this study was to observe the hemodynamic changes during surgical extraction of lower third molars induced by three local anesthetics solutions associated with different vasoconstrictors. A double-blind observational and longitudinal study was made of 45 healthy adult volunteers subjected to surgical removal of an impacted lower third molar under local anesthesia. Three groups were established (n = 15) according to the anesthetic solution and associated vasoconstrictor administered (4% articaine + epinephrine 1:200,000; 3% mepivacaine without vasoconstrictor; and 3% prilocaine + felypressin 1:1,850,000). Heart rate, systolic and diastolic pressure, and oxygen saturation were recorded at different times before, during and at the end of surgery, along with the type and amount of anesthetic solution administered. The study variables were found to be more stable with articaine + epinephrine 1:200,000, although the three studied solutions caused no significant hemodynamic changes with respect to the basal values when administered in healthy patients subjected to surgical removal of a lower third molar.
authors.affiliation: Faculty of Dentistry, University of Barcelona, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Carrera
authors.forename: R
authors.initials: R
authors.lastname: Mestre
authors.forename: L
authors.initials: L
authors.lastname: Berini
authors.forename: C
authors.initials: C
authors.lastname: Gay-Escoda
mesh_terms: D000293:Adolescent; D000328:Adult; D000766:Anesthesia, Dental; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D002355:Carticaine / Q000008:administration & dosage; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage; D005259:Felypressin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008334:Mandible; D008619:Mepivacaine / Q000008:administration & dosage; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D015999:Multivariate Analysis; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000187:drug effects; D011318:Prilocaine / Q000008:administration & dosage; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
chemical_list: D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D011318:Prilocaine; D005259:Felypressin; D008619:Mepivacaine; D002355:Carticaine; D010100:Oxygen; D004837:Epinephrine