Oxidative stress and neurodegeneration in prion diseases.
Transmissible spongiform encephalopathies (TSEs), also termed prion diseases, are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. The pathogenesis and the molecular basis of neuronal cell death in these diseases are not well understood. Oxidative stress has been proposed to play an important role in the pathogenesis of several neurodegenerative disorders. In the present study, evidence of oxidative stress in scrapie, the archetype disease of the TSEs, is discussed. In addition, the mechanisms whereby oxidative stress could lead to neuronal degeneration are described.
Kim
J I
JI
Institute of Environment & Life Science, College of Medicine, Hallym University, Chuncheon, Kangwon-do, South Korea.
Choi
S I
SI
Kim
N H
NH
Jin
J K
JK
Choi
E K
EK
Carp
R I
RI
Kim
Y S
YS
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D009410:Nerve Degeneration / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D018621:PrPC Proteins / Q000378:metabolism; D018620:PrPSc Proteins / Q000378:metabolism; D017096:Prion Diseases / Q000378:metabolism* / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012608:Scrapie / Q000378:metabolism / Q000473:pathology; D012756:Sheep; D014158:Transcription, Genetic
D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D018621:PrPC Proteins; D018620:PrPSc Proteins; D017382:Reactive Oxygen Species