The use of tiagabine in affective disorders.
We reviewed the available literature on the efficacy of a novel anticonvulsant, Tiagabine (TGB), in the treatment of bipolar disorder. Study results indicate that TGB does not represent a valid option in acute mania due its required slow, progressive titration. More rapid titration schemes may lead to severe complications. TGB may be an option as an adjunct long-term treatment approach in refractory patients, but further studies are clearly needed to support this.
Carta
M G
MG
Psychiatric Unit, Department of Public Health, University of Cagliari, Via Liguria 13, 09127 Cagliari, Italy. mgcarta@tiscalinet.it
Hardoy
M C
MC
Grunze
H
H
Carpiniello
B
B
D000927:Anticonvulsants / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy*; D009557:Nipecotic Acids / Q000627:therapeutic use*; D000078308:Tiagabine
D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine