title: Glutaraldehyde in hospital wastewater.
abstract: Glutaraldehyde (GA) solutions are widely used in hospitals to disinfect reusable fiber-optic endoscopes. These solutions are dumped after use in the aquatic environment without any particular safety precautions. Taking into account the quantity of GA consumed daily and the released water volume, the predicted hospital wastewater concentration was estimated at 0.50 mg/L. To measure the real GA concentration present in hospital wastewater, we developed an analytical technique that is simple, sensitive, and reliable. This method consists of a water sample concentration and purification by solid phase extraction and then a spectrophotometric determination. This analytical method was used for a 1-week surveillance program at Rouen University Hospital (2,600 beds). The wastewater tested showed the presence of a concentrated peak approximately eight times higher than the predicted wastewater concentration. The environmental impact of GA release into the aquatic environment was then studied. A predicted no-effect concentration (PNEC) < 1 microg/L was calculated. In most situations the predicted environmental concentration (PEC) was found to be <0.5 microg/L taking into account the hospital wastewater dilution in its way to the sewage treatment plant and GA biodegradation. The PEC/PNEC ratio is then < 1, showing that this release are not expected to present a significant risk to the aquatic environment. However in situations of insufficient dilution or of major release, the PEC/PNEC ratio become > 1, and an environmental risk should be expected. An internal prevention program of the various hospital departments to assure GA rational use, and a release spreading would give an additional safety margin to consider GA as safe in terms of environmental risk.
authors.affiliation: Toxicology Laboratory, Faculty of Medicine and Pharmacy, 22 Bd. Gambetta, F-76183 Rouen cedex, France. Boris.Jolibois@univ-rouen.fr
authors.forename: B
authors.initials: B
authors.lastname: Jolibois
authors.forename: M
authors.initials: M
authors.lastname: Guerbet
authors.forename: S
authors.initials: S
authors.lastname: Vassal
mesh_terms: D004202:Disinfectants / Q000032:analysis*; D004784:Environmental Monitoring; D005976:Glutaral / Q000032:analysis*; D008506:Medical Waste / Q000032:analysis*; D017744:Medical Waste Disposal; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D004202:Disinfectants; D008506:Medical Waste; D017744:Medical Waste Disposal; D014874:Water Pollutants, Chemical; D005976:Glutaral