title: Effects of noise on the off rate of Ca(2+) binding proteins in a coupled biochemical cell system.
abstract: We investigated numerically the kinetic properties of calcium binding proteins by using a three-calcium store model and discussed the response of a two-way coupled biochemical cell system, whose subsystems were coupled via diffusion-like cytosolic calcium transfer through gap junctions, to the external stimulation. When we used noise to modulate the off rate of the Ca(2+) binding proteins in simulation, an SR-like phenomenon of synchronous oscillations is observed. In addition, the interaction involving noise, coupling and the dynamics of Ca(2+) binding proteins is discussed.
authors.affiliation: Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: F
authors.initials: F
authors.lastname: Qi
authors.forename: H
authors.initials: H
authors.lastname: Xin
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000378:metabolism* / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D003198:Computer Simulation; D003600:Cytosol / Q000378:metabolism; D017629:Gap Junctions / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D013269:Stochastic Processes
chemical_list: D002135:Calcium-Binding Proteins; D002118:Calcium