The effect of single-dose oxytocin application on time to ejaculation and seminal parameters in men.
OBJECTIVE
To report the effect of a single dose of oxytocin on ejaculation time and seminal parameters.


METHODS
The prospective randomized clinical study was performed at a private assisted reproduction technology center and included 103 consecutive healthy men (semen donors or husbands of IVF patients). Oxytocin (16 IU) were administered intranasally to 49 subjects, randomly assigned to the study group just before masturbation to ejaculation. The time needed for ejaculation as well as the semen parameters was recorded according to the WHO standards, and compared to the control group of 54 subjects with no prior oxytocin treatment.


RESULTS
No significant difference was noted between the two groups concerning ejaculation time and semen parameters.


CONCLUSIONS
Although the administration of oxytocin stimulates sexual behavior and performance in mammalian species, our data indicate that oxytocin has no detectable effect on ejaculation time and seminal parameters after intranasal application in normal, healthy men.
Walch
K
K
Department of Obstetrics and Gynecology, Kaiser Franz Josef Hospital, Vienna, Austria.
Eder
R
R
Schindler
A
A
Feichtinger
W
W
D000281:Administration, Intranasal; D000328:Adult; D004542:Ejaculation / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010121:Oxytocin / Q000008:administration & dosage*; D011446:Prospective Studies; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism*
D010121:Oxytocin