Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report.
We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo 14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.
Mohty
M
M
Laboratoire d'Immunologie des Tumeurs, Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France.
Faucher
C
C
Gaugler
B
B
Vey
N
N
Sainty
D
D
Arnoulet
C
C
Mozziconacci
M J
MJ
Isnardon
D
D
Gastaut
J A
JA
Maraninchi
D
D
Olive
D
D
Blaise
D
D
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003602:Cytotoxicity, Immunologic; D020350:Graft vs Tumor Effect; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000628:therapy*; D008218:Lymphocytosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous