Cytotoxic triterpenoides from Alismatis Rhizoma.
Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation using in vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with ED50 values of 7.5, 7.5, 4.9 microg/ml, respectively.
Lee
S
S
Korea Research Institute of Bioscience and Biotechnology, Taejon.
Kho
Y
Y
Min
B
B
Kim
J
J
Na
M
M
Kang
S
S
Maeng
H
H
Bae
K
K
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002783:Cholestenones / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D002783:Cholestenones; C457233:alisol A 24-acetate; C401295:alisol B monoacetate; C457234:alisol C 23-acetate; C457232:alisol B