title: [Time for extubation and sequential noninvasive mechanical ventilation in COPD patients with exacerbated respiratory failure who received invasive ventilation].
abstract: OBJECTIVE
  To discuss the optimal time for extubation and sequential non-invasive mechanical ventilation in COPD patients with exacerbated respiratory failure who received invasive ventilation.
  
  
  METHODS
  24 patients received invasive ventilation for 3 days were randomly assigned to receive noninvasive ventilation (study group) or to continue the weaning process with invasive ventilation (control group). The incidence of ventilator-associated pneumonia (VAP), the incidence of death, the duration of ventilation, the hospitalization were analyzed in two groups.
  
  
  RESULTS
  Between study group and control group, the incidence of VAP was 0/12 vs 7/12, P = 0.027; the incidence of death was 0/12 vs 3/12, P = 0.217; the continued duration of ventilation after invasive ventilation for 3 days was (7 +/- 5) days vs (15 +/- 12) days, P < 0.05; the hospitalization was (16 +/- 6) days vs (25 +/- 12) days, P < 0.05, respectively.
  
  
  CONCLUSIONS
  In COPD patients with exacerbated respiratory failure who received invasive ventilation, invasive ventilation for 3 days followed by noninvasive ventilation may decrease the incidence of VAP, shorten the duration of ventilation and hospitalization.
authors.affiliation: Department of Respiratory Medicine, Huzhou Central Hospital, Huzhou 313000, China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: D
authors.initials: D
authors.lastname: Qiu
authors.forename: D
authors.initials: D
authors.lastname: Tao
mesh_terms: D000368:Aged; D006801:Humans; D008875:Middle Aged; D011014:Pneumonia / Q000209:etiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000401:mortality / Q000628:therapy*; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D013997:Time Factors