[Retrospective cohort study on the prognosis of chronic myeloid leukemia].
OBJECTIVE
To evaluate the prognostic factors of chronic myeloid leukemia (CML).


METHODS
Survival curves were plotted according to the Kaplan-Meier method. Variables associated with prognosis were analyzed by Logrank test. A multivariate analysis of prognostic factors was performed using stepwise Cox model.


RESULTS
Of the total 158 patients, the median survival time was 1,480 days. 5 years survival rate was 47.1% (95% CI, 36.7% - 56.9%). 10 years was 24.8% (95% CI, 15.0% - 35.8%). The predominant blastic crisis type is myeloblastic, myelomonocytic or monocytic(77.5%). The period from chronic phase to blastic phase was equal in myelosuppressive therapy group, non- myelosuppressive therapy group or altretamine (HMM) group. After evaluated by stepwise Cox's regression model, age>or=50 years, bone marrow blasts>or=0.05, bone marrow basophilic>or=0.05, Ph chromosome negative and HMM treatment were associated with poor prognosis. Hydroxyurea was always associated with longer survival.


CONCLUSIONS
Age, Ph chromosome, bone marrow blasts and basophilic, and various treatment affected the survival of CML.
Liang
X
X
Department of Hematology, Huashan Hospital, Shanghai Medical University, Shanghai 200040, China.
Lin
G
G
Zhang
W
W
Shen
Y
Y
Tang
Z
Z
Wu
W
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D015996:Survival Rate