title: Parameters for reliable results in genetic association studies in common disease.
abstract: It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.
authors.affiliation: JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Dahlman
authors.forename: Iain A
authors.initials: IA
authors.lastname: Eaves
authors.forename: Roman
authors.initials: R
authors.lastname: Kosoy
authors.forename: V Anne
authors.initials: VA
authors.lastname: Morrison
authors.forename: Joanne
authors.initials: J
authors.lastname: Heward
authors.forename: Stephen C L
authors.initials: SC
authors.lastname: Gough
authors.forename: Amit
authors.initials: A
authors.lastname: Allahabadia
authors.forename: Jayne A
authors.initials: JA
authors.lastname: Franklyn
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: Eva
authors.initials: E
authors.lastname: Tuomilehto-Wolf
authors.forename: Francesco
authors.initials: F
authors.lastname: Cucca
authors.forename: Cristian
authors.initials: C
authors.lastname: Guja
authors.forename: Constantin
authors.initials: C
authors.lastname: Ionescu-Tirgoviste
authors.forename: Helen
authors.initials: H
authors.lastname: Stevens
authors.forename: Philippa
authors.initials: P
authors.lastname: Carr
authors.forename: Sarah
authors.initials: S
authors.lastname: Nutland
authors.forename: Patricia
authors.initials: P
authors.lastname: McKinney
authors.forename: Julian P
authors.initials: JP
authors.lastname: Shield
authors.forename: William
authors.initials: W
authors.lastname: Wang
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Cordell
authors.forename: Neil
authors.initials: N
authors.lastname: Walker
authors.forename: John A
authors.initials: JA
authors.lastname: Todd
authors.forename: Patrick
authors.initials: P
authors.lastname: Concannon
mesh_terms: D020413:3' Untranslated Regions; D030541:Databases, Genetic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005828:Genetics, Population; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide
chemical_list: D020413:3' Untranslated Regions; D018664:Interleukin-12