Cell polarity: following formin function.
Mutation of a novel fission yeast formin, for3p, leads to marked changes in both the actin and microtubule cytoskeleton, as well as a surprising asymmetric pattern of cell growth. At the same time, new work in budding yeast implicates formins directly in actin filament assembly.
Sawin
Kenneth E
KE
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Swann Building, Mayfield Road, EH9 3JR, Edinburgh, UK. ken.sawin@ed.ac.uk
D008841:Actin Cytoskeleton / Q000648:ultrastructure; D000199:Actins / Q000378:metabolism; D018797:Cell Cycle Proteins; D002455:Cell Division; D016764:Cell Polarity; D000080865:Formins; D008870:Microtubules / Q000648:ultrastructure; D008954:Models, Biological; D009154:Mutation; D017434:Protein Structure, Tertiary; D012568:Schizosaccharomyces / Q000254:growth & development* / Q000648:ultrastructure; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D000199:Actins; D018797:Cell Cycle Proteins; C444419:FOR3 protein, S pombe; D000080865:Formins; D029702:Schizosaccharomyces pombe Proteins