L-myc genotype is associated with different susceptibility to lung cancer in smokers.
We have shown that L-myc genotype is associated with the risk of esophageal cancer from smoking and heavy drinking. In this study, we have analyzed the relationship between the L-myc genotypes and lung cancer risk from smoking in 191 Japanese lung-cancer patients and 241 non-cancer controls. The odds ratios (ORs) were markedly higher in SS and LS genotypes than in LL genotype; age-sex-adjusted ORs were 3.19, 2.30 and 0.92, respectively. This result suggests that the L-myc polymorphism may affect the induction of lung cancer by smoking. The OR for smoking in SS-genotype patients diagnosed within 2 years was higher than that in other SS patients, suggesting that smoking-related lung cancer in SS genotype might exhibit a poorer prognosis.
Kumimoto
Hiroshi
H
Central Laboratory and Radiation Biology, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Aichi 464-8681, Japan. kumimoto@aichi-cc.jp
Hamajima
Nobuyuki
N
Nishimoto
Yoshio
Y
Matsuo
Keitaro
K
Shinoda
Masayuki
M
Hatooka
Shunzo
S
Ishizaki
Kanji
K
D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D000483:Alleles; D018287:Carcinoma, Large Cell / Q000209:etiology / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000209:etiology / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics; D016022:Case-Control Studies; D004247:DNA / Q000097:blood / Q000378:metabolism; D005260:Female; D016259:Genes, myc / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
D004247:DNA