Soluble CD30 as a predictor of kidney graft outcome.
BACKGROUND
In the present study, we investigated whether the soluble form of CD30 (sCD30), a marker for T helper 2-type cytokine-producing T cells, is increased in sera of potential kidney graft recipients. We also investigated whether the pretransplantation serum sCD30 content is related to kidney graft survival.


METHODS
Pretransplantation sera of 844 cadaver kidney recipients from three transplant centers in Germany were tested for serum sCD30 content using a commercially available ELISA kit.


RESULTS
Kidney graft recipients showed a significantly higher serum sCD30 content than healthy controls (P<0.0001). High sCD30 serum content was associated with graft rejection. The 2-year graft survival rate in recipients with a high pretransplantation serum sCD30 was 68+/-6%, significantly lower than the 86+/-1% rate in recipients with a low sCD30 (P<0.0001). Importantly, high sCD30 was indicative of an increased risk of graft loss even in recipients without lymphocytotoxic alloantibodies.


CONCLUSIONS
These data show that an elevated pretransplantation serum sCD30 reflects an immune state that is detrimental for kidney graft survival.
Pelzl
Steffen
S
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany.
Opelz
Gerhard
G
Wiesel
Manfred
M
Schnülle
Peter
P
Schönemann
Constanze
C
Döhler
Bernd
B
Süsal
Caner
C
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002102:Cadaver; D005260:Female; D006085:Graft Survival / Q000276:immunology / Q000502:physiology*; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017730:Ki-1 Antigen / Q000097:blood*; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D008297:Male; D012016:Reference Values; D012086:Reoperation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*; D013997:Time Factors; D014019:Tissue Donors
D015415:Biomarkers; D007166:Immunosuppressive Agents; D017730:Ki-1 Antigen