[Carcinogenicity of bile from cholecystolithiasis patients].
OBJECTIVE
To study the carcinogenicity of bile from cholecystolithiasis patients and the relationship between cholecystolithiasis and gallbladder carcinoma (GBC).


METHODS
The bile from 18 cholecystolithiosis patients was examined by Ames test and two-stage cell transformation assay.


RESULTS
The bile from cholecystolithiosis patients could significantly promote the formation of BALB/c3T3 cell transformation (P = 0.0233). The bile from symptomatic patients was much more active in tumor promotion than that from asymptomatic patients (P < 0.05).


CONCLUSIONS
The bile in cholecystolithiasis patients exhibits a tumor-promoter activity, which may account for the high incidence of GBC among cholecystolithiasis patients.
Ma
Z
Z
Department of General Surgery, First Hospital, Dalian Medical University, Dalian 116011, China.
Wang
Z
Z
Zhang
J
J
D016475:3T3 Cells; D000328:Adult; D000368:Aged; D000818:Animals; D001646:Bile / Q000737:chemistry / Q000502:physiology*; D001647:Bile Acids and Salts / Q000494:pharmacology*; D015197:Carcinogenicity Tests; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000473:pathology; D002769:Cholelithiasis / Q000737:chemistry* / Q000150:complications; D005260:Female; D005706:Gallbladder Neoplasms / Q000209:etiology; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged
D001647:Bile Acids and Salts