title: Magnesium: its proven and potential clinical significance.
abstract: Magnesium is the fourth most abundant cation in the body and is present in more than 300 enzymatic systems, where it is crucial for adenosine triphosphate (ATP) metabolism. Deficiency states result in increased insulin resistance, as well as increased smooth muscle and platelet reactivity. Magnesium deficiency has been shown to correlate with a number of chronic cardiovascular diseases, including hypertension, diabetes mellitus, and hyperlipidemia. Intravenous magnesium has been used therapeutically in critical situations such as status asthmaticus, torsades de pointes, and preeclampsia. Few controlled studies exist regarding the therapeutic uses of oral magnesium supplementation in chronic cardiovascular diseases. Randomized clinical trials are urgently needed to determine whether magnesium supplementation will alter the natural history of these disease states.
authors.affiliation: Department of Family Medicine, State University of New York at Buffalo, 14215, USA.
authors.forename: C
authors.initials: C
authors.lastname: Fox
authors.forename: D
authors.initials: D
authors.lastname: Ramsoomair
authors.forename: C
authors.initials: C
authors.lastname: Carter
mesh_terms: D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D003920:Diabetes Mellitus / Q000503:physiopathology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008274:Magnesium / Q000502:physiology / Q000627:therapeutic use*; D008275:Magnesium Deficiency / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D009203:Myocardial Infarction / Q000188:drug therapy / Q000209:etiology; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000209:etiology
chemical_list: D008274:Magnesium