Systemic adverse effects of ophthalmic beta-blockers.
OBJECTIVE
To review published clinical information on the systemic adverse effects of ophthalmic beta-blockers for the purpose of developing a pilot contraindication/warning system for active prescriptions in the Veterans Affairs dispensing database.


METHODS
Articles were identified by searching MEDLINE (1966-October 2000) and International Pharmaceutical Abstracts (1970-October 2000).


METHODS
Article relevance was determined by review of titles, abstracts, and key words.


RESULTS
The preponderance of the evidence suggests that ophthalmic beta-blockers may be associated with bronchospasm and adverse cardiovascular effects including bradycardia. Depression and other central nervous system effects are reported less commonly. Data are inadequate to suggest that ophthalmic beta-blocker use is routinely associated with adverse metabolic effects.


CONCLUSIONS
The strongest level of evidence (grade A1) supports a contraindication for use of ophthalmic beta-blockers for respiratory disease, with a moderate level of evidence (grade B1) for cardiovascular disease. Data are insufficient to support or refute contraindications for other disease states. The search technique and classification scheme described in this article provide a methodology for evaluating, grading, and applying evidence on potential adverse effects of drug therapy.
Vander Zanden
J A
JA
Department of Pharmacy Practice, School of Pharmacy, UCHSC, 4200 E. Ninth Ave., Box C-238, Denver, CO 80262-0238, USA.
Valuck
R J
RJ
Bunch
C L
CL
Perlman
J I
JI
Anderson
C
C
Wortman
G I
GI
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects; D002319:Cardiovascular System / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects; D000075202:Contraindications; D006787:Hospitals, Veterans; D006801:Humans; D009883:Ophthalmic Solutions; D012137:Respiratory System / Q000187:drug effects*; D012871:Skin Diseases / Q000139:chemically induced*; D014481:United States
D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions