title: Amprenavir inhibitory quotient and virological response in human immunodeficiency virus-infected patients on an amprenavir-containing salvage regimen without or with ritonavir.
abstract: The efficacy of an amprenavir (APV)-containing therapy without (group A) or with (group B) ritonavir was assessed in patients with failure of previous protease inhibitor therapy for human immunodeficiency virus (HIV) infection. The mean minimal plasma APV concentrations in groups A and B were 58 and 1,320 ng/ml, respectively, corresponding to APV inhibitory quotients of 0.2 (range, 0.03 to 0.70) and 7.0 (range, 1.4 to 145), respectively. At week 24, 2 of 8 and 13 of 14 patients in groups A and B, respectively, had <200 HIV RNA copies/ml of plasma, including 4 of 5 patients infected with APV-resistant viruses.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Hôpital Bichat Claude Bernard, Paris, France. xavier.duval@bch.ap-hop-paris.fr
authors.forename: Xavier
authors.initials: X
authors.lastname: Duval
authors.forename: Claire
authors.initials: C
authors.lastname: Lamotte
authors.forename: Ester
authors.initials: E
authors.lastname: Race
authors.forename: Diane
authors.initials: D
authors.lastname: Descamps
authors.forename: Florence
authors.initials: F
authors.lastname: Damond
authors.forename: François
authors.initials: F
authors.lastname: Clavel
authors.forename: Catherine
authors.initials: C
authors.lastname: Leport
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Vilde
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002219:Carbamates; D004359:Drug Therapy, Combination; D005663:Furans; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D012367:RNA, Viral / Q000187:drug effects*; D019438:Ritonavir / Q000627:therapeutic use; D013449:Sulfonamides / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D002219:Carbamates; D005663:Furans; D012367:RNA, Viral; D013449:Sulfonamides; C095108:amprenavir; D019438:Ritonavir