Abietic acid inhibits lipoxygenase activity.
In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.
Ulusu
N Nuray
NN
Hacettepe University, Faculty of Medicine, Department of Biochemistry, 06100 Ankara, Turkey.
Ercil
Dilek
D
Sakar
M Koray
MK
Tezcan
E Ferhan
EF
D028202:Abies; D045784:Abietanes; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D019787:Linoleic Acid / Q000494:pharmacology; D008084:Lipoxygenase / Q000378:metabolism*; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D045784:Abietanes; D004224:Diterpenes; D004791:Enzyme Inhibitors; D010616:Phenanthrenes; D010936:Plant Extracts; D019787:Linoleic Acid; D008084:Lipoxygenase; C023710:abietic acid