Inversion of the anatomical lateralization of chick thalamofugal visual pathway by light experience.
It has been reported that light exposure to one eye induces functional lateralization, which can be inverted by exposing the opposite eye to the light. However, the anatomical basis of the functional inversion by the light has not been shown. To address this issue, we labeled cells in the dorsolateral anterior thalamus (DLA) using retrograde fluorescent tracers injected into visual Wulst, counted the labeled cell number, and compared the anatomical asymmetry of DLA between the left eye occluded and the right eye occluded chickens. We found that a rostral part of DLA (DLAda) and a lateral/ventral part of DLA differentially projected to the visual cortex ipsilaterally and contralaterally, respectively. These regions showed anatomical asymmetry that was inverted by the light. An antibody against a nicotinic acetylcholine receptor subunit more intensively and widely stained the side of DLA receiving the light stimulation and the cell labeled by the tracers co-localized with the immunoreactive neuropil. These results indicated that the light experience induced the anatomical lateralization of thalamofugal visual pathway.
Koshiba
Mamiko
M
Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, 187-8502, Tokyo, Japan.
Kikuchi
Tateki
T
Yohda
Masafumi
M
Nakamura
Shun
S
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D019521:Body Patterning / Q000502:physiology; D002452:Cell Count; D002645:Chickens / Q000033:anatomy & histology / Q000254:growth & development*; D005456:Fluorescent Dyes; D007839:Functional Laterality / Q000502:physiology*; D007150:Immunohistochemistry; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology; D010775:Photic Stimulation; D011978:Receptors, Nicotinic / Q000378:metabolism; D012683:Sensory Deprivation / Q000502:physiology; D013687:Telencephalon / Q000166:cytology / Q000254:growth & development*; D013788:Thalamus / Q000166:cytology / Q000254:growth & development*; D014795:Visual Pathways / Q000166:cytology / Q000254:growth & development*
D005456:Fluorescent Dyes; D011978:Receptors, Nicotinic; D000109:Acetylcholine