Characteristics of bone morphogenetic protein-induced chondroid bone: histochemical, immunohistochemical and in situ hybridization examinations.
The third ossification mode, known as transchondroid bone formation, is displayed chiefly in the bone morphogenetic protein (BMP)-induced heterotopic bone formation model. This paper describes the results of histopathological, histochemical, immunohistochemical, and in situ hybridization examinations of BMP-induced heterotopic bone in mice. The research focuses on the localization of typical matrix proteins (peptide and its mRNA) of cartilage and bone--type-I and type-II collagen, osteocalcin and osteopontin--in the chondroid bone matrix.
Kawakami
T
T
Division of Oral and Maxillofacial Biology, Matsumoto Dental University Institute for Dental Science, Shiojiri, Japan. kawakami@po.mdu.ac.jp
Kawai
T
T
Kimura
A
A
Hasegawa
H
H
Tsujigiwa
H
H
Gunduz
M
M
Nagatsuka
H
H
Nagai
N
N
D000818:Animals; D001846:Bone Development / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000502:physiology*; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D024042:Collagen Type I; D012333:RNA, Messenger