Enzymatically cleavable linker groups in polymer-supported synthesis.
Access to broadly applicable linker groups that are stable under a variety of reaction conditions and enable the release of target compounds from polymeric supports under the mildest conditions is a major goal in combinatorial chemistry. Here, we summarize the development of enzymatically cleavable linker groups used to prepare a variety of different target molecules on polymeric supports.
Reents
Reinhard
R
Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, D-44227 Dortmund, Germany.
Jeyaraj
Duraiswamy A
DA
Waldmann
Herbert
H
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004798:Enzymes / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation
D004798:Enzymes; D011108:Polymers