The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen.
Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (6,7,10). While the vast majority of tumor cells from these malignancies are latently infected, only a small subset of viral genes are actually expressed (5,40,47). Of these genes, the latency-associated nuclear antigen (LANA-1, LNA, or LNA1) is the only protein consistently shown to be highly expressed by in situ hybridization and immunohistochemistry (11,20,21,32). Moreover, within the past few years LANA-1 has proven to be a quite versatile protein, playing not only a pivotal role in KSHV episome persistence, but also in interacting with and influencing several cellular genes.
Komatsu
T
T
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Barbera
A J
AJ
Ballestas
M E
ME
Kaye
K M
KM
D000818:Animals; D000956:Antigens, Viral; D019288:Herpesvirus 8, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000096:biosynthesis*; D012514:Sarcoma, Kaposi / Q000821:virology*; D017735:Virus Latency
D000956:Antigens, Viral; D009687:Nuclear Proteins; C109540:latency-associated nuclear antigen