title: GAW12: simulated genome scan, sequence, and family data for a common disease.
abstract: The Genetic Analysis Workshop (GAW) 12 simulated data involves a common disease defined by imposing a threshold on a quantitative liability distribution. Associated with the disease are five quantitative risk factors, a quantitative environmental exposure, and a dichotomous environmental variable. Age at disease onset and household membership were also simulated. Genotype data, including 2,855 microsatellites on 22 autosomes, were simulated for 1,497 individuals in 23 families. Phenotype data and sequence data for seven candidate genes were provided for 1,000 of these individuals who were "living" and available for study. Data were simulated for 50 replicate samples in each of two populations, a general population and a population isolate formed from a small group of founders.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, P.O. Box 760549, San Antonio, TX 78245-0549, USA.
authors.forename: L
authors.initials: L
authors.lastname: Almasy
authors.forename: J D
authors.initials: JD
authors.lastname: Terwilliger
authors.forename: D
authors.initials: D
authors.lastname: Nielsen
authors.forename: T D
authors.initials: TD
authors.lastname: Dyer
authors.forename: D
authors.initials: D
authors.lastname: Zaykin
authors.forename: J
authors.initials: J
authors.lastname: Blangero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005828:Genetics, Population; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D008957:Models, Genetic; D010641:Phenotype; D011110:Polymorphism, Genetic; D019655:Quantitative Trait, Heritable; D011995:Recombination, Genetic
chemical_list: D005819:Genetic Markers