title: Management of premature rupture of membranes.
abstract: The management of patients with PROM, regardless of gestational age, remains controversial. Generally, when patients are in labor, have infection, or there is irreversible fetal distress, there are few options other than delivery. For those not in labor, especially in premature gestational ages, the complexities of the many combinations of decisions to be made regarding the best methods for evaluating patients, prolonging gestation, reducing complications of prematurity, and choosing the timing and route of delivery make studying and solving the problem of the best option for management difficult at best. The administration of corticosteroids and broad-spectrum antibiotics of those patients in the very early premature gestational age groups has now been shown clearly to improve outcome. Beyond that, the remainder of these problems are somewhat unresolved and several reasonable options often exist and are likely to remain so for some time to come.
authors.affiliation: Department of Obstetrics and Gynecology, University of California Irvine, Orange, California, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Garite
mesh_terms: D002821:Chorioamnionitis / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods*; D012307:Risk Factors