Linkage analysis of Genetic Analysis Workshop 12 simulated data based on affected individuals only.
A variety of allele-sharing methods was used to assess linkage to disease for a whole-genome screen in each of ten replicates from the Genetic Analysis Workshop 12 simulated data. Analysis of each replicate produced many false positive results in addition to a few "true" positives. Conditioning on the strongest initial linkage and reanalyzing using a variety of conditional methods did not improve the power for detection or help discriminate between true and false positive signals.
Cordell
H J
HJ
Dept. of Medical Genetics, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Addenbrookes Hospital, Cambridge CB2 2XY, UK.
Dudbridge
F
F
D000483:Alleles; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008432:Mathematical Computing; D008957:Models, Genetic; D010641:Phenotype; D012984:Software