title: Association study of the p53-gene Pro72Arg polymorphism in schizophrenia.
abstract: The p53 tumor-suppressor gene, encoding a phosphoprotein, is a key element in maintaining genomic stability and cell apoptosis. It is also implicated in nervous-system development. In order to examine the role of the p53 gene for the pathogenesis of schizophrenic disorders, patients (n=155) and control subjects (n=168) were genotyped for the p53-Pro72Arg polymorphism. The results demonstrated no association with schizophrenia and/or age of onset for this polymorphism.
authors.affiliation: Institute of Public Health, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: H J
authors.initials: HJ
authors.lastname: Chiu
authors.forename: Y C
authors.initials: YC
authors.lastname: Wang
authors.forename: J Y
authors.initials: JY
authors.lastname: Chen
authors.forename: C J
authors.initials: CJ
authors.lastname: Hong
authors.forename: S J
authors.initials: SJ
authors.lastname: Tsai
mesh_terms: D000328:Adult; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*