title: Lung perfusion affects preload assessment and lung water calculation with the transpulmonary double indicator method.
abstract: OBJECTIVE
  The transpulmonary double indicator method uses intra- and extravascular indicators to calculate cardiac output, intrathoracic blood volume, global end-diastolic volume, and extravascular lung water content. Since lung perfusion may be of importance during these measurements, we studied the effects of pulmonary blood flow occlusion on measurements obtained with this method.
  
  
  METHODS
  Experimental animal facility of a University department.
  
  
  METHODS
  In seven pigs, the branch of the pulmonary artery perfusing the lower and middle lobe of the right lung was occluded. Measurements before, during, and after the occlusion were made with a pulmonary artery catheter and a commonly used transpulmonary double indicator catheter and device.
  
  
  RESULTS
  Occlusion of the right lower and middle lobe branch of the pulmonary artery increased mean pulmonary pressure (before occlusion: 24+/-1, during occlusion: 32+/-2, after reopening 25+/-1 mmHg; P<0.05), increased right ventricular end-diastolic volume (172+/-34, 209+/-21, 174+/-32 ml, respectively; P<0.05), decreased intrathoracic blood volume (998+/-39, 894+/-48, 1006+/-49 ml, respectively; P<0.05), and decreased extravascular lung water (7.2+/-0.5, 4.2+/-0.4, 6.9+/-0.4 ml/kg, respectively; P<0.05) without causing significant changes in cardiac output. All changes were reversible upon reopening the vessel.
  
  
  CONCLUSIONS
  These data show that the transpulmonary double indicator method may underestimate extravascular lung water and right ventricular preload when the perfusion to parts of the lung is obstructed.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, University of Jena, Jena, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Schreiber
authors.forename: L
authors.initials: L
authors.lastname: Hüter
authors.forename: K
authors.initials: K
authors.lastname: Schwarzkopf
authors.forename: H
authors.initials: H
authors.lastname: Schubert
authors.forename: N
authors.initials: N
authors.lastname: Preussler
authors.forename: F
authors.initials: F
authors.lastname: Bloos
authors.forename: E
authors.initials: E
authors.lastname: Gaser
authors.forename: W
authors.initials: W
authors.lastname: Karzai
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002245:Carbon Dioxide / Q000378:metabolism; D002404:Catheterization; D015633:Extravascular Lung Water / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D010477:Perfusion; D011651:Pulmonary Artery / Q000503:physiopathology*; D018709:Statistics, Nonparametric; D013552:Swine; D013815:Thermodilution / Q000379:methods*
chemical_list: D002245:Carbon Dioxide