title: [A case of locally recurrent breast cancer in which phlebothrombosis of the right leg after hormonal therapy using a high dose of toremifene citrate].
abstract: A 72-year-old female had undergone mastectomy at the age of 67 for right breast cancer (T2a, n1 alpha, positive for ER). In the surgery the pectoralis muscle was preserved. For adjuvant therapy, 20 mg/day of tamoxifen was orally administered for 5 years. Six years after surgery, relapse was detected in the right major pectoralis muscle. Irradiation at this site and oral administration of 120 mg/day of toremifene citrate were started. The patient had a medical history of diabetes, and the control of her blood sugar was poor. About 2 months after oral administration of toremifene citrate was started, flares with blebs and swelling were observed in the right lower leg, suggesting acute phlebothrombosis of the right lower limb. The symptoms were ameliorated by intravenous administration of heparin and an antibiotic. In administering a high dose of toremifene citrate to patients with complications, careful follow-up is needed.
authors.affiliation: Third Dept. of Surgery, Toho University School of Medicine.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sakuta
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Sumiyama
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Noto
authors.forename: Iwao
authors.initials: I
authors.lastname: Naka
authors.forename: Takaharu
authors.initials: T
authors.lastname: Kiribayashi
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007866:Leg; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D017312:Toremifene / Q000008:administration & dosage / Q000009:adverse effects*; D020246:Venous Thrombosis / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D018931:Antineoplastic Agents, Hormonal; D005343:Fibrinolytic Agents; D017312:Toremifene; D006493:Heparin