[The effect of Paeonol on erythrocyte deformability determined by micropipette aspiration technique].
OBJECTIVE
The effect of Paeonol (PAE) on erythorcyet(RBC) deformability was studied in order to provide experimental data for the application in clinic and the evaluation in pharmacological action.


METHODS
Micropipette Aspiration Technique was used to determine the RBC deformation length. The method of calculation was also simplified and a new apparent deformation Index(ADI) was defined.


RESULTS
PAE could increase the ADImin and ADImax and decrease Tmax significantly.


CONCLUSIONS
PAE has the effect of deformational ability on RBC. Micropipette aspiration technique is a feasible method for determining the effect of traditional Chinese medicine on erythrocyte deformability.
Li
W
W
Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405.
Cai
S
S
Wang
Y
Y
Huang
Q
Q
Song
G
G
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D003584:Cytological Techniques / Q000379:methods; D004907:Erythrocyte Deformability / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012815:Signal Processing, Computer-Assisted
D000098:Acetophenones; C013638:paeonol