title: Integrative genetic element that reverses the usual target gene orientation.
abstract: A genetic element integrating site specifically into a prokaryotic gene usually carries a copy of the 3' portion of that gene that restores the active gene even as the original is disrupted. A cryptic element in Mesorhizobium loti instead carries a copy of the 5' end of the tRNA gene into which it integrated. This has implications for the evolution of new integrase-site combinations.
authors.affiliation: Department of Biology, Indiana University, 1001 East Third St., Bloomington, IN 47405, USA.
authors.forename: Sihui
authors.initials: S
authors.lastname: Zhao
authors.forename: Kelly P
authors.initials: KP
authors.lastname: Williams
mesh_terms: D001483:Base Sequence; D004251:DNA Transposable Elements / Q000235:genetics*; D019143:Evolution, Molecular; D005798:Genes, Bacterial; D019426:Integrases / Q000378:metabolism; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics*; D012230:Rhizobiaceae / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D019426:Integrases