title: [(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.
abstract: The synthesis of a new potent, subtype-selective radioligand [(3)H]-M-MPEP (2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine) and its in vitro pharmacological characteristics are described. Science Ltd.
authors.affiliation: Nervous System Research, Novartis Pharma AG, 4002 Basel, Switzerland. fabrizio.gasparini@pharma.novartis.com
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Gasparini
authors.forename: Hendrik
authors.initials: H
authors.lastname: Andres
authors.forename: Peter Josef
authors.initials: PJ
authors.lastname: Flor
authors.forename: Micheline
authors.initials: M
authors.lastname: Heinrich
authors.forename: Werner
authors.initials: W
authors.lastname: Inderbitzin
authors.forename: Kurt
authors.initials: K
authors.lastname: Lingenhöhl
authors.forename: Hanspeter
authors.initials: H
authors.lastname: Müller
authors.forename: Veronica Cecilia
authors.initials: VC
authors.lastname: Munk
authors.forename: Kyla
authors.initials: K
authors.lastname: Omilusik
authors.forename: Christine
authors.initials: C
authors.lastname: Stierlin
authors.forename: Natacha
authors.initials: N
authors.lastname: Stoehr
authors.forename: Ivo
authors.initials: I
authors.lastname: Vranesic
authors.forename: Rainer
authors.initials: R
authors.lastname: Kuhn
mesh_terms: D001665:Binding Sites; D001667:Binding, Competitive / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008024:Ligands; D011725:Pyridines / Q000494:pharmacology*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism
chemical_list: D008024:Ligands; D011725:Pyridines; D019275:Radiopharmaceuticals; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D011994:Recombinant Proteins; C120148:SIB 1893; C121465:6-methyl-2-(phenylethynyl)pyridine