[Experimental study on effect of qishejingkang recipe on activity of alkaline phosphatases in osteophyte formation of degenerated cervical vertebrae of rabbits].
OBJECTIVE
To study the effect of Qishejingkang recipe (QSJKR) on activity of alkaline phosphatase (ALP) in osteophyte formation of degenerated cervical vertebrae.


METHODS
A model of degenerated cervical vertebrae in the rabbit was established through resection of the cervical supraspinous and interspinous ligaments from the cervical spine elicited by surgical intervention. The sites of osteophyte was observed with a light microscope. The activity of ALP of the annuls fibrosis and nucleus pulpous, end-plate in each cervical spine was assayed with biochemical method respectively.


RESULTS
Osteophyte come from end-plate, the activity of ALP in the degenerated end-plate in QSJKR group declined significantly compared with model group.


CONCLUSIONS
QSJKR could decrease the activity of ALP in end-plate of degenerated cervical vertebrae and it might inhibit the formation of osteophyte.
Wang
Y
Y
Institute of Orthopedics and Traumatology, Shanghai University of TCM, Shanghai (200032).
Shi
Q
Q
Shen
P
P
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002574:Cervical Vertebrae / Q000201:enzymology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D013128:Spinal Osteophytosis / Q000201:enzymology*
D004365:Drugs, Chinese Herbal; D000469:Alkaline Phosphatase