Recent developments in combinatorial organic synthesis.
The level of sophistication of combinatorial synthesis continues to increase at a heady pace. Fairly complex target molecules are now being assembled combinatorially using a broad palette of organic reactions both in solution- and solid-phase. This review highlights academic and industrial examples of combinatorial synthesis published within the last year. Recent advances in small-molecule synthesis are outlined, ranging from simple acyclic scaffolds to complex natural products.
Ganesan
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Department of Chemistry, University of Southampton, Southampton, UK SO17 1BJ. ganesan@soton.ac.uk
D001685:Biological Factors / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000639:trends*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D006839:Hydrocarbons, Acyclic / Q000138:chemical synthesis
D001685:Biological Factors; D006571:Heterocyclic Compounds; D006839:Hydrocarbons, Acyclic