title: [Effect of the SH-group of myelopeptide MP-3 on its macrophage-stimulating activity].
abstract: Peptide Leu-Val-Cys-Tyr-Pro-Gln, identical to the bone marrow peptide MP-3, and its Val3 and Ser3 analogs, lacking SH-group, were synthesized by conventional methods of peptide chemistry in solution and, along with the MP-3 S-S-dimerization product, were studied with respect to their effect on the macrophage phagocytic activity. It was shown that the activity was only enhanced by peptide MP-3, which demonstrated the essential role of the SH-group in this function. The dimer analog of MP-3, unlike dimer analogs of other monocysteine-containing peptides, glutathione and HP5b, did not exhibit the inhibitory effect.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP Moscow, 117997 Russia. stas@ibch.ru
authors.forename: L A
authors.initials: LA
authors.lastname: Fonina
authors.forename: M I
authors.initials: MI
authors.lastname: Baldin
authors.forename: M A
authors.initials: MA
authors.lastname: Efremov
authors.forename: S A
authors.initials: SA
authors.lastname: Gur'ianov
authors.forename: R G
authors.initials: RG
authors.lastname: Belevskaia
mesh_terms: D000595:Amino Acid Sequence; D001853:Bone Marrow / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D008262:Macrophage Activation / Q000187:drug effects*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D009842:Oligopeptides; D013438:Sulfhydryl Compounds; C048617:myelopeptides