[Study on the relation between hypertensive left ventricular hypertrophy in very old people with neurohormonal factors and ventricular arrhythmias].
OBJECTIVE
To study the relation between hypertensive left ventricular hypertrophy (LVH) in very old people (> 80 year) with neuro-hormone factors and ventricular arrhythmias.


METHODS
Measurements were made on the heart rate variation, renin (Ren), angiotensin-II (AT-II), aldosterone (Ald), insulin (Ins), Holter and ambulatory blood pressure monitor in 60 cases of 2 groups: 30 with primary hypertension in very old people and LVH (group A); 30 with simple primary hypertension in very old people (group B).


RESULTS
(1) There was no significant difference of AT-II and Ren among group A and B (P > 0.05); (2) Ins and Ald value in group A was much higher than group B (P all < 0.01); (3) Very lower frequency (VLF) and low frequency (LF) and LF/HF (high frequency) in group A were significantly higher than group B (P < 0.01, 0.05, 0.05, respectively); (4) incidence of premature ventricular beats and myocardial ischemia in group A were higher than those in group B.


CONCLUSIONS
(1) Sympathetic nerve excitability in group A was greatly increased; (2) Hypertensive LVH were closely associated with Ald and Ins level, but not with AT-II and Ren; (3) There was obvious correction between group A and premature ventricular beats and ischemia.
Guo
H
H
The Affiliated Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou 310016, China.
Lu
D
D
Wang
J
J
He
H
H
Zhou
B
B
Jiang
C
C
D000368:Aged; D000369:Aged, 80 and over; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D001145:Arrhythmias, Cardiac / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D015994:Incidence; D008297:Male; D017202:Myocardial Ischemia / Q000453:epidemiology; D012083:Renin / Q000097:blood
D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin