title: Case report: primary human herpesvirus-6 associated with an afebrile seizure in a 3-week-old infant.
abstract: We describe a 3-week-old male infant with an afebrile seizure in whom serologic and polymerase chain reaction (PCR) findings support concomitant primary human herpesvirus 6 (HHV-6) infection. Although HHV-6 infection has been associated with first-time febrile seizures and encephalitis in both immunocompetent and immunocompromised hosts, it has not been associated previously with afebrile seizures in healthy infants. This report provides additional evidence of the neuropathogenic potential of HHV-6.
authors.affiliation: Department of Pediatrics, University of Washington, Seattle, Washington, USA. zerr@u.washington.edu
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Zerr
authors.forename: Laurence C
authors.initials: LC
authors.lastname: Yeung
authors.forename: Rose Mary
authors.initials: RM
authors.lastname: Obrigewitch
authors.forename: Meei-Li
authors.initials: ML
authors.lastname: Huang
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Frenkel
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D019349:Roseolovirus Infections / Q000097:blood / Q000150:complications / Q000821:virology*; D012640:Seizures / Q000097:blood / Q000150:complications / Q000821:virology*