title: Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2).
abstract: The safety, infectivity, and immunogenicity of two human-bovine reassortant rotavirus candidate vaccines were evaluated in adults, children, and infants. One of these, Wa x UK, contained a single human rotavirus gene from the Wa strain that encoded VP4 P1A specificity in a background of 10 bovine genes including the VP7 gene that encodes G6 specificity, whereas the other, Wa x (DS-1 x UK), possessed the human rotavirus VP4 gene from the Wa strain as well as the human VP7 gene from strain DS-1 that encoded G2 specificity. Each of these vaccines appeared to be well-tolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates.
authors.affiliation: Center for Immunization Research, Department of International Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
authors.forename: Maryna C
authors.initials: MC
authors.lastname: Eichelberger
authors.forename: Ellen
authors.initials: E
authors.lastname: Sperber
authors.forename: Mariam
authors.initials: M
authors.lastname: Wagner
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Robert
authors.initials: R
authors.lastname: Dudas
authors.forename: Vicki
authors.initials: V
authors.lastname: Hodgins
authors.forename: Jennifer
authors.initials: J
authors.lastname: Marron
authors.forename: Pamela
authors.initials: P
authors.lastname: Nehring
authors.forename: Roberta
authors.initials: R
authors.lastname: Casey
authors.forename: Barbara
authors.initials: B
authors.lastname: Burns
authors.forename: Ruth
authors.initials: R
authors.lastname: Karron
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Clements-Mann
authors.forename: Albert Z
authors.initials: AZ
authors.lastname: Kapikian
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral; D002213:Capsid / Q000235:genetics / Q000276:immunology; D036022:Capsid Proteins; D002417:Cattle; D002478:Cells, Cultured; D002675:Child, Preschool; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D008875:Middle Aged; D011995:Recombination, Genetic; D012401:Rotavirus / Q000235:genetics / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D022243:Rotavirus Vaccines; C060339:VP4 protein, Rotavirus; C050779:VP7 protein, Rotavirus