Functioning of systems of the neutral amino acid transport in enterocyte brush-border membranes of rat small intestine under normal conditions and after ionising radiation.
Peculiarities of neutral amino acid (L-leucine and L-phenylalanine) transport in brush-border membranes of rat small intestine enterocytes under normal conditions and following a 1.0-Gy X-ray irradiation have been studied. The increase of the brush-border membrane permeability for ions and amino acids is considered to be the main reason of the post-irradiation disorders in the transmembrane transport of amino acids. The radiobiological approach made it possible to corroborate the existence of a Na+-dependent L-phenylalanine transport system different from the common system for neutral amino acids.
Hizhnyak
S V
SV
Shevchenko Kiev University, Ukraine.
Bublik
A A
AA
Voitsitsky
V M
VM
Kucherenko
N E
NE
D021542:Amino Acids, Neutral / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000528:radiation effects; D020895:Enterocytes / Q000378:metabolism / Q000528:radiation effects*; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D007930:Leucine / Q000378:metabolism*; D008871:Microvilli / Q000378:metabolism / Q000528:radiation effects; D010649:Phenylalanine / Q000378:metabolism*; D051381:Rats
D021542:Amino Acids, Neutral; D010649:Phenylalanine; D007930:Leucine