title: Elevated C-reactive protein is associated with an increased intima to media thickness of the common carotid artery.
abstract: In this study, we analyzed the relationship between serum C-reactive protein (CRP) and the intima to media thickness (IMT) of the common carotid artery in 411 consecutive neurological inpatients (215 males, mean age 64.1 years). The CRP concentration was determined within 12 h and patients were subdivided according to the CRP level. Patients with an elevated CRP (n = 149) showed a significantly larger IMT [1.05 mm (95% confidence interval (CI) 1.02-1.09) vs. 0.92 mm (95% CI 0.89-0.94)]. Multivariate linear regression analysis revealed that an elevated CRP level, age, pack-years of smoking, body mass index, incidence of diabetes mellitus and ischemic stroke were independently associated with an increased IMT (p < 0.05).
authors.affiliation: Department of Neurology, Technical University of Munich, Germany. Winbeck@neuro.med.tu-muenchen.de
authors.forename: Kerstin
authors.initials: K
authors.lastname: Winbeck
authors.forename: Christian
authors.initials: C
authors.lastname: Kukla
authors.forename: Holger
authors.initials: H
authors.lastname: Poppert
authors.forename: Jürgen
authors.initials: J
authors.lastname: Klingelhöfer
authors.forename: Bastian
authors.initials: B
authors.lastname: Conrad
authors.forename: Dirk
authors.initials: D
authors.lastname: Sander
mesh_terms: D000368:Aged; D001167:Arteritis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D018616:Ultrasonography, Doppler, Duplex
chemical_list: D002097:C-Reactive Protein