title: Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine.
abstract: [reaction: see text] L-2'-Fluoro-4'-thio-2',3'-unsaturated cytidine 11 was synthesized from (R)-2-fluorobutenolide 2, which was prepared from 2,3-O-isopropylidene-L-glyceraldehyde 1. The synthesized compound 11 shows potent antiviral activity against HIV-1.
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, Georgia 30602, USA.
authors.forename: Yongseok
authors.initials: Y
authors.lastname: Choi
authors.forename: Hyunah
authors.initials: H
authors.lastname: Choo
authors.forename: Youhoon
authors.initials: Y
authors.lastname: Chong
authors.forename: Sookwang
authors.initials: S
authors.lastname: Lee
authors.forename: Sureyya
authors.initials: S
authors.lastname: Olgen
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
authors.forename: Chung K
authors.initials: CK
authors.lastname: Chu
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line / Q000187:drug effects; D003562:Cytidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D015224:Dideoxynucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D013872:Thionucleosides / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; C449043:L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine; D013872:Thionucleosides; D003562:Cytidine