Flow cytometry of isolated mitochondria during development and under some pathological conditions.
Mitochondria play an essential role in the generation of the energy needed for eukaryotic cell life and in the release of molecules involved in initiation of cell death. Here we review the changes in isolated mitochondrial fluorescent populations as distinguished by flow cytometry during postnatal development and their regulation by thyroid hormones and catecholamines. The use of flow cytometry in the study of mitochondrial changes occurring under hypothyroidism, alcohol abuse and aging is also reviewed.
Medina
José M
JM
Departmento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Salamanca, Spain.
López-Mediavilla
Casilda
C
Orfao
Alberto
A
D000375:Aging / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism; D008928:Mitochondria / Q000737:chemistry* / Q000473:pathology / Q000502:physiology*; D013963:Thyroid Hormones / Q000378:metabolism
D002395:Catecholamines; D013963:Thyroid Hormones