Aggravation of glaucoma with fluvoxamine.
OBJECTIVE
To report a case of aggravation of glaucoma associated with the use of fluvoxamine.


METHODS
A 66-year-old while woman diagnosed with narrow-angle glaucoma showed an increase in intraocular pressure and experienced orbital pain and blurred vision after the initiation of fluvoxamine for tension-type headache. These symptoms disappeared and intraocular pressure normalized after withdrawal of this drug.


CONCLUSIONS
Aggravation of narrow-angle glaucoma is a well-known adverse effect of tricyclic antidepressants. Because this adverse effect had been rarely reported to date with selective serotonin-reuptake inhibitors (paroxetine and fluoxetine), we used fluvoxamine in our patient. The disappearance of ocular symptoms and the normalization of intraocular pressure two days after stopping fluvoxamine suggest a possible relationship between fluvoxamine and aggravation of glaucoma.


CONCLUSIONS
Fluvoxamine should be considered as a drug that can induce or aggravate narrow-angle glaucoma.
Jiménez-Jiménez
F J
FJ
Departamento de Medicina-Neurología, Hospital Príncipe de Asturias, Universidad de Alcalá, Carretera de Meco S/N, E-28805, Alcalá de Henares, Spain. fjimenezj@meditex.es
Ortí-Pareja
M
M
Zurdo
J M
JM
D000368:Aged; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects*; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors