[Development of a canine model of chronic progressive right ventricular hypertension].
BACKGROUND
Several animal models of right ventricle hypertension (RVH) have been produced through pulmonary artery banding with linen, tygon or teflon. Nevertheless few devices attempting a progressive, step by step graduated chronic development of RVH have been reported. The present study describes the results in our animal model of chronic RVH.


METHODS
We designed a software programmed to obtain hemodynamic data and installed a small occlusive hydraulic device (OHD) at the pulmonary artery trunk producing a raise in the right ventricular systolic pressure (RVSP); this pressure can be modified externally through the OHD. We studied 12 healthy mongrel dogs (18 to 28 kg of weight) in the course of 6 months. Hemodynamic measurements were performed at different RVSP at two months intervals; (Baseline, 40 mmHg and 60 mmHg).


RESULTS
The software was useful to analyze several hemodynamic variables at each RVSP. At 60 mmHg, the end diastolic pressure of the right ventricle (RVEDP) increased from 4.2 +/- 0.4 mmHg to 13.2 +/- 1.1 mmHg, p < 0.000, accompanied with a fall in cardiac output adjusted to the dogs weight from 0.16 +/- 0.03 L/min/kg to 0.09 +/- 0.01 L/min/kg, p > 0.000. Also an increase of the end diastolic pressure of the left ventricle (LVEDP) from 7.4 +/- 0.8 mmHg to 16.3 +/- 2.8 mmHg, p < 0.000, was observed. RVSP was maintained in chronic condition and the intraclass correlation coefficient was 0.83, P < 0.005.


CONCLUSIONS
Right ventricular chronic hypertension is created. The device is useful and reliable to maintain chronic increments of RVSP. The software permits a versatile analysis.
Santos Martínez
L E
LE
Departamento de Cardioneumología, Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, Col. Sección XVI, 14080 México, D.F. lsantosm@correoweb.com
Gómez González
A
A
Infante Vázquez
O
O
Flores Chávez
P
P
Tena Betancourt
C
C
Pulido Zamudio
T
T
Martínez Guerra
M L
ML
Martínez Memije
R
R
Graullera Rivera
V
V
Sandoval Zárate
J
J
D000818:Animals; D002309:Cardiology / Q000295:instrumentation; D002908:Chronic Disease; D004195:Disease Models, Animal; D018450:Disease Progression; D004285:Dogs; D004867:Equipment Design; D006976:Hypertension, Pulmonary / Q000209:etiology*; D018497:Ventricular Dysfunction, Right / Q000150:complications*