[The effect of Xuezhikang on oxidation of low-density lipoproteins in vitro].
OBJECTIVE
To study the effect of Xuezhikang on oxidation of human low-density lipoprotein.


METHODS
In vitro experiment was used to study the effect of Xuezhikang on the change of human low-density lipoprotein. Relative electrophoresis movement rate after oxidation of low-density lipoprotein mediated by addition of copper ion was observed.


RESULTS
Oxidation of low-density lipoprotein mediated by copper ion was accelerated as the time of action prolonged and the process was accompanied by increased relative electrophoresis movement rate. Oxidation of low-density lipoprotein by copper ion was inhibited significantly in the presence of Xue zhikang as compared with absence of XuezhiKang at all time points. A greater reduction of reactive electrophoresis movement rate up to 33.5%, (P < 0.05) was noted. With increase of Xuezhikang concentration, the extent of reduction increased.


CONCLUSIONS
It is shown that human low-density lipoprotein can be oxidized by mediation of copper ion and XuezhiKang may inhibit the extent of oxidation of low-density lipoprotein by copper ion.
Xu
B
B
The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029.
Cheng
W
W
Lu
X
X
D003300:Copper / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004586:Electrophoresis; D006801:Humans; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010084:Oxidation-Reduction
D004365:Drugs, Chinese Herbal; D008077:Lipoproteins, LDL; D003300:Copper