Helminth infections are associated with protection from malaria-related acute renal failure and jaundice in Thailand.
Following studies showing an association between helminth infections and protection from cerebral malaria, we compared 22 patients with malaria-associated acute renal failure with 157 patients with moderately severe malaria. Helminths were associated with protection from renal failure (adjusted odds ratio [AOR], 0.16 [0.03-0.85], P = 0.03). Helminth-infected controls were less likely to have jaundice (AOR, 0.39 [0.16-0.96], P = 0.04) or to have peripheral mature schizonts (AOR, 0.2 [0.07-0.62], P = 0.005) than controls without helminths. This suggested that preexisting helminth infections may have been protective by influencing sequestration and obstructive jaundice, 2 possible determinants of acute tubular necrosis.
Nacher
M
M
Unité INSERM 511, Immunobiologie Cellulaire et Moléculaire des Infections Parasitaires, Faculté de medecine Pitié-Salpétrière, Paris, France.
Singhasivanon
P
P
Silachamroon
U
U
Treeprasertsuk
S
S
Vannaphan
S
S
Traore
B
B
Gay
F
F
Looareesuwan
S
S
D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D005260:Female; D006373:Helminthiasis / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007565:Jaundice / Q000209:etiology*; D008288:Malaria / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D008297:Male; D016017:Odds Ratio; D011446:Prospective Studies; D012720:Severity of Illness Index; D013785:Thailand / Q000453:epidemiology