Synthesis and antimycobacterial activity of new S-alkylisothiosemicarbazone derivatives.
A new series of S-alkylisothiosemicarbazones of 3- and 4-pyridincarboxaldehyde and 4-fluoro- and 4-trifluoromethylbenzaldehyde was synthesized and evaluated for biological activity against various Mycobacterium strains. Inhibitory activity against Mycobacterium tuberculosis H37Rv ATCC 27294 and INH-R ATCC 35822 was compared with activity against clinical isolated Mycobacteria as well as against MOTT. Some of newly prepared compounds showed best inhibitory values against clinical isolated Mycobacteria, besides to low citotoxicity values.
Cocco
Maria Teresa
MT
Dipartimento di Tossicologia, Universita di Cagliari, Via Ospedale 72-09124, Cagliari, Italy. tcocco@unica.it
Congiu
Cenzo
C
Onnis
Valentina
V
Pellerano
Maria Luisa
ML
De Logu
Alessandro
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002522:Chlorocebus aethiops; D008826:Microbial Sensitivity Tests; D009159:Mycobacteriaceae / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D013882:Thiosemicarbazones