title: New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.
abstract: Based on the 7-OH-2-(aminomethyl)chroman dopamine D(2) template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4).
authors.affiliation: Global Chemical Sciences Department, Wyeth-Ayerst Research Laboratories, PO Box 42528, Philadelphia, PA 19101-2528, USA. mewshar@war.wyeth.com
authors.forename: Richard E
authors.initials: RE
authors.lastname: Mewshaw
authors.forename: Rulin
authors.initials: R
authors.lastname: Zhao
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Shi
authors.forename: Karen
authors.initials: K
authors.lastname: Marquis
authors.forename: Julie A
authors.initials: JA
authors.lastname: Brennan
authors.forename: Hossein
authors.initials: H
authors.lastname: Mazandarani
authors.forename: Joseph
authors.initials: J
authors.lastname: Coupet
authors.forename: Terrance H
authors.initials: TH
authors.lastname: Andree
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry*; D018491:Dopamine Agonists / Q000138:chemical synthesis / Q000737:chemistry*; D008961:Models, Structural; D017448:Receptors, Dopamine D2 / Q000008:administration & dosage / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013698:Templates, Genetic
chemical_list: C456399:2-(N-benzylaminomethyl)-7-hydroxybenzopyran; D001578:Benzopyrans; D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2