Localized 2D correlation spectroscopy in human brain at 3 T.
The purpose of this study was to acquire a localized 2D (two-dimensional) 1H correlation spectrum, in a volume of interest reasonably small, and within an experiment time compatible with clinical applications. A modified PRESS technique has been used. The last 180 degrees pulse of the PRESS sequence has been converted into a 90 degrees pulse for both refocusing and coherence transfer. 2D correlation spectroscopy was performed on healthy volunteers in a clinical magnet, at 3 T, within 34 min, for a voxel size of 27 cm3. This result makes it possible to consider clinical applications.
Ziegler
Anne
A
Unité mixte INSERM, Université J. Fourier U438 'RMN Bioclinique', LRC CEA, CHU pavillon B, BP 217, 38043 Cedex 9, Grenoble, France. anne.ziegler@ujf-grenoble.fr
Gillet
Brigitte
B
Beloeil
Jean-Claude
JC
Macher
Jean-Paul
JP
Décorps
Michel
M
Nédelec
Jean-François
JF
D001921:Brain / Q000473:pathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D013053:Spectrophotometry; D013997:Time Factors