title: Protein turnover: a CHIP programmed for proteolysis.
abstract: The Hsp70 co-chaperone CHIP has recently gained attention as a regulator of protein turnover. CHIP has now been reported to be a component of the ubiquitination cascade, specifically an E3 ligase. CHIP appears to be part of a system that diverts incorrectly folded proteins from chaperones to the proteasome.
authors.affiliation: Institute for Biochemistry and Molecular Biology, University of Freiburg, Hermann-Herder-Strasse 7, D-79104, Freiburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Wiederkehr
authors.forename: B
authors.initials: B
authors.lastname: Bukau
authors.forename: A
authors.initials: A
authors.lastname: Buchberger
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology*; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D004268:DNA-Binding Proteins; D008025:Ligases / Q000737:chemistry / Q000502:physiology; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D014157:Transcription Factors; D044767:Ubiquitin-Protein Ligases
chemical_list: C091732:BCL2-associated athanogene 1 protein; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D009097:Multienzyme Complexes; D011506:Proteins; D011965:Receptors, Glucocorticoid; D014157:Transcription Factors; C467728:STUB1 protein, human; D044767:Ubiquitin-Protein Ligases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D008025:Ligases