Short-term effect of chloroquine on the infectivity of Plasmodium chabaudi gametocytes.
The short-term enhancing effect of chloroquine on gametocyte infectivity was investigated with Plasmodium chabaudi chabaudi, a synchronous parasite which is highly sensitive to chloroquine. In comparison with control groups, oocyst numbers increased in mosquitoes fed on mice 12 hours after the injection of 5 mg/kg chloroquine (180% of controls) although it was not statistically significant. No effect was seen with 1 mg/kg chloroquine. The authors interpretation is that chloroquine impaired the schizogony, thus reducing also the release of toxic material of parasite origin which blocks gametocytes infectivity. Results of similar experiments with other rodent species of Plasmodium are compared and discussed in relation with the chronobiological characteristics of these parasites.
Gautret
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P
Laboratoire de Parasitologie et de Mycologie Médicale, Pavillon Guérin, CHU la Miletrie, BP 577, 86021 Poitiers, France. gautret@cict.fr
Voza
T
T
Chabaud
A G
AG
Landau
I
I
D000818:Animals; D000852:Anopheles / Q000187:drug effects* / Q000254:growth & development; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D008018:Life Cycle Stages; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D009865:Oocytes; D016788:Plasmodium chabaudi / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors; D016896:Treatment Outcome
D000962:Antimalarials; D002738:Chloroquine