Two-trait-locus linkage analyses of asthma susceptibility.
A genome-wide search was conducted to identify chromosomal regions likely to harbor genes for asthma susceptibility. One hundred and twelve Caucasian families ascertained through a proband with a diagnosis of asthma by the Collaborative Study on the Genetics of Asthma (CSGA) were used for this search. Genotype data on 323 polymorphic markers were analyzed via parametric and nonparametric linkage analysis in an initial genome scan to identify potential asthma susceptibility region(s). The regions where hold or nonparametric linkage scores were greater than 2.0 were selected for further investigation using two-trait-locus linkage analysis models.
Nath
S K
SK
Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13th St., Oklahoma City, OK 73104, USA.
Chen
C H
CH
Schork
N J
NJ
D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D004843:Epistasis, Genetic; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008957:Models, Genetic; D019655:Quantitative Trait, Heritable; D018709:Statistics, Nonparametric; D014481:United States
D005819:Genetic Markers