The use of sequential designs in genome scans for asthma susceptibility loci with affected sib pairs.
We use optimized group sequential study designs to analyze data from two genome scans (German and CSGA) for asthma susceptibility loci with affected sib pairs from Genetic Analysis Workshop (GAW) 12. Results are compared with those from a fixed sample design and the sequential probability ratio test (SPRT). The SPRT does not reach significance at any position. Using the fixed sample design, evidence for linkage is found on chromosomes 6 and 9 in the German and on chromosome 1 in the CSGA scan. The group sequential designs identify the same regions on chromosomes 1 and 6 with a reduced sample size.
Böddeker
I R
IR
Institute of Medical Biometry and Epidemiology, Center for Methodology and Health Research, Philipps-University of Marburg, Bunsenstr. 3, 35033 Marburg, Germany.
Müller
H H
HH
Kress
R
R
Geller
F
F
Ziegler
A
A
Schäfer
H
H
D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005828:Genetics, Population; D016678:Genome; D005858:Germany; D006801:Humans; D008297:Male; D008957:Models, Genetic; D014481:United States