title: Family-based tests of association in the presence and absence of known linkage.
abstract: Correlation among sibling marker genotypes may invalidate the results of family-based tests of association in the presence of linkage. We apply an empirical variance estimation method, which is implemented in the program package FBAT, on Caucasian families with asthma in the presence and absence of linkage and compare the results with those obtained using the TDT (TDTEX-PAIRS) on the same data sets. Our results indicate that both tests generally perform comparably in either setting.
authors.affiliation: Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
authors.forename: L
authors.initials: L
authors.lastname: Bertram
authors.forename: B
authors.initials: B
authors.lastname: Hayward
authors.forename: S L
authors.initials: SL
authors.lastname: Lake
authors.forename: K
authors.initials: K
authors.lastname: Falls
authors.forename: P
authors.initials: P
authors.lastname: Van Erdewegh
authors.forename: D
authors.initials: D
authors.lastname: Blacker
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002895:Chromosomes, Human, Pair 5; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D005858:Germany; D006801:Humans; D008297:Male; D008432:Mathematical Computing; D012984:Software; D014481:United States
chemical_list: D005819:Genetic Markers