The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease.
The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis. Increasing evidence indicates that diffuse lung disease results from an imbalance between the pro-inflammatory and anti-inflammatory mechanisms, with a persistent imbalance that favors pro-inflammatory mediators dictating the development of chronic diffuse lung disease. This review focuses on the mediators that influence this imbalance.
Keane
Michael P
MP
Department of Medicine, Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, USA. mpkeane@mednet.ucla.edu
Strieter
Robert M
RM
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D016207:Cytokines / Q000502:physiology; D006706:Homeostasis / Q000276:immunology; D018836:Inflammation Mediators / Q000502:physiology* / Q000627:therapeutic use; D008171:Lung Diseases / Q000188:drug therapy* / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D018836:Inflammation Mediators