title: [Efficacy of 40-O-(2-hydroxyethyl)-rapamycin in preventing chronic renal allograft rejection in rats].
abstract: OBJECTIVE
  To study the efficacy of 40-O-(2-hydroxyethyl)-rapamycin (SDZ RAD) in preventing chronic renal allograft rejention in rats.
  
  
  METHODS
  The rat model of chronic renal allograft rejection was made with micro-surgery. The recipients were divided into two groups. The recipients in the study group were treated with SDZ RAD at a dose of 0.5 mg x kg(-1) x d(-1) by means of gavage and the controls with vehicle.
  
  
  RESULTS
  After 24 weeks of treatment, proteinuria, glomerular sclerosis, vascular intimal thickening and the infiltration of monocytesmacrophages and lymphocytes in the study group were decreased, in consistence with the reduced expression of ICAM-1, VCAM-1, TGF-beta(1) and PDGF-AA mRNA.
  
  
  CONCLUSIONS
  It is suggested that SDZ RAD can prevent chronic renal allograft rejection and the reduced expression of above adhesion molecules and growth factors may be involved in the mechanism.
authors.affiliation: Institute of Transplantation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510120.
authors.forename: H
authors.initials: H
authors.lastname: Zou
authors.forename: J
authors.initials: J
authors.lastname: Bai
authors.forename: D
authors.initials: D
authors.lastname: Lai
mesh_terms: D000818:Animals; D000068338:Everolimus; D006084:Graft Rejection / Q000517:prevention & control*; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D016030:Kidney Transplantation; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D020123:Sirolimus / Q000031:analogs & derivatives / Q000627:therapeutic use*; D014184:Transplantation, Homologous; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis
chemical_list: D007166:Immunosuppressive Agents; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D000068338:Everolimus; D020123:Sirolimus