title: Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride.
abstract: Scleroderma is a multisystem disorder frequently resulting in disturbed GI motility. Although, especially early in the disease, symptomatic improvement is achieved with prokinetic agents, more severe GI manifestations of scleroderma may be difficult to treat, leading to parenteral feeding and hospitalization. Recently, a new serotonin (5-HT4) receptor agonist prucalopride was shown to have remarkable prokinetic properties, resulting in symptomatic improvement and increased frequency of defecation in patients with chronic functional constipation. Here we report two cases of scleroderma with GI manifestation in which previous prokinetic treatment failed, but where the patients were successfully treated with prucalopride. Our data suggest that prucalopride may be a promising and effective drug to treat GI motility disorders in scleroderma. However, further placebo-controlled double blind studies are needed for full documentation of the usefulness of prucalopride in patients with scleroderma.
authors.affiliation: Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: G E
authors.initials: GE
authors.lastname: Boeckxstaens
authors.forename: J F W M
authors.initials: JF
authors.lastname: Bartelsman
authors.forename: L
authors.initials: L
authors.lastname: Lauwers
authors.forename: G N J
authors.initials: GN
authors.lastname: Tytgat
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005765:Gastrointestinal Agents / Q000008:administration & dosage; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000209:etiology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008365:Manometry; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications* / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D001572:Benzofurans; D005765:Gastrointestinal Agents; C406662:prucalopride