Activation of the inflammatory response system in autism.
OBJECTIVE
There is now some evidence that autism may be accompanied by abnormalities in the inflammatory response system (IRS). Products of the IRS, such as proinflammatory cytokines, may induce some of the behavioral symptoms of autism, such as social withdrawal, resistance to novelty and sleep disturbances. The main aim of the present study was to examine whether autism is accompanied by an activation of the IRS.


METHODS
We measured the production of interleukin (IL)-6, IL-10, the IL-1 receptor antagonist (IL-1RA), interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha by whole blood and the serum concentrations of IL-6, the IL-2 receptor (IL-2R) and IL-1RA.


RESULTS
This study showed a significantly increased production of IFN-gamma and IL-1RA and a trend toward a significantly increased production of IL-6 and TNF-alpha by whole blood of autistic children. There were no significant differences in the serum concentrations of IL-6, IL-2R and IL-1RA between autistic and normal children.


CONCLUSIONS
These results suggest that autism may be accompanied by an activation of the monocytic (increased IL-1RA) and Th-1-like (increased IFN-gamma) arm of the IRS. It is hypothesized that increased production of proinflammatory cytokines could play a role in the pathophysiology of autism.
Croonenberghs
Jan
J
University Center of Child and Adolescent Psychiatry, Antwerp, Belgium.
Bosmans
Eugene
E
Deboutte
Dirk
D
Kenis
Gunter
G
Maes
Michael
M
D000293:Adolescent; D001321:Autistic Disorder / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D046508:Culture Techniques; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007371:Interferon-gamma / Q000097:blood; D053590:Interleukin 1 Receptor Antagonist Protein; D016753:Interleukin-10 / Q000097:blood; D053645:Interleukin-2 Receptor alpha Subunit; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D018123:Receptors, Interleukin / Q000097:blood; D012795:Sialoglycoproteins / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015415:Biomarkers; D016207:Cytokines; C507763:IL1RN protein, human; C508017:IL2RA protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053645:Interleukin-2 Receptor alpha Subunit; D015850:Interleukin-6; D018123:Receptors, Interleukin; D012795:Sialoglycoproteins; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma