title: Functioning acinar cell pancreatic carcinoma: diagnosis on mangafodipir trisodium (Mn-DPDP)-enhanced MRI.
abstract: We describe the imaging findings of a functional pancreatic acinar cell carcinoma in a patient who presented with weight loss, hyperlipasemia, and multiple foci of subcutaneous fat necrosis. The tumor invaded the adjacent splenic and portal vein, causing isolated left-sided portal hypertension. At MRI, the tumor showed marked enhancement following administration of the hepatobiliary-specific contrast agent mangafodipir trisodium (Mn-DPDP), thereby demonstrating the functional nature of the tumor. Avid uptake of Mn-DPDP by a functioning pancreatic tumor has not been reported in the radiology literature.
authors.affiliation: Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Dushyant
authors.initials: D
authors.lastname: Sahani
authors.forename: Srinivasa R
authors.initials: SR
authors.lastname: Prasad
authors.forename: Michael
authors.initials: M
authors.lastname: Maher
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Warshaw
authors.forename: Peter F
authors.initials: PF
authors.lastname: Hahn
authors.forename: Sanjay
authors.initials: S
authors.lastname: Saini
mesh_terms: D000368:Aged; D018267:Carcinoma, Acinar Cell / Q000473:pathology*; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008345:Manganese; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid