title: Activities of faropenem, an oral beta-lactam, against recent U.S. isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.
abstract: The in vitro activities of faropenem and other antimicrobial agents were determined against 4,725 Streptococcus pneumoniae isolates, 2,614 Haemophilus influenzae isolates, and 1,193 Moraxella catarrhalis isolates collected from 273 U.S. laboratories during 1999. Faropenem MICs at which 90% of isolates are inhibited were 0.008, 0.25, and 1 microg/ml for penicillin-susceptible, -intermediate, and -resistant S. pneumoniae strains, respectively; 0.5 and 1 microg/ml for beta-lactamase-positive and -negative H. influenzae strains, respectively; and 0.12 and 0.5 microg/ml for beta-lactamase-negative and -positive M. catarrhalis strains, respectively. Faropenem holds promise as an oral therapy for community-acquired respiratory tract infections.
authors.affiliation: Focus Technologies, Inc. (formerly MRL), Herndon, Virginia 20171, USA.
authors.forename: Ian A
authors.initials: IA
authors.lastname: Critchley
authors.forename: James A
authors.initials: JA
authors.lastname: Karlowsky
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Draghi
authors.forename: Mark E
authors.initials: ME
authors.lastname: Jones
authors.forename: Clyde
authors.initials: C
authors.lastname: Thornsberry
authors.forename: Kate
authors.initials: K
authors.lastname: Murfitt
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Sahm
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D007769:Lactams; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000201:enzymology; D014481:United States; D001618:beta-Lactamases / Q000378:metabolism; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams; D047090:beta-Lactams; D001618:beta-Lactamases; C107057:fropenem