title: Role of p53 mutations on survival after pancreatoduodenectomy for ductal adenocarcinoma of the pancreatic head.
abstract: OBJECTIVE
  To determine the role of p53 mutations on survival after pancreatoduodenectomy for adenocarcinoma of the pancreatic head.
  
  
  METHODS
  Resected specimens were assessed for expression of wild-type or mutated p53. Survival of p53-negative and- positive patients was investigated, and differences noted at 0.05 level.
  
  
  RESULTS
  Expression of wild-type p53 is associated with a significant improvement in overall survival, especially for patients without nodal metastases.
  
  
  CONCLUSIONS
  Preoperative p53 determination could enable further patient selection for aggressive surgery.
authors.affiliation: HPB Unit, First Division of General Surgery, Galliera Hospital, Genoa, Italy.
authors.forename: G M
authors.initials: GM
authors.lastname: Gazzaniga
authors.forename: F S
authors.initials: FS
authors.lastname: Papadia
authors.forename: M
authors.initials: M
authors.lastname: Dezzana
authors.forename: S
authors.initials: S
authors.lastname: Cappato
authors.forename: M
authors.initials: M
authors.lastname: Filauro
authors.forename: R
authors.initials: R
authors.lastname: Bandelloni
mesh_terms: D000368:Aged; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D009367:Neoplasm Staging; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis