A case of exaggerated mosquito-bite hypersensitivity with Epstein-Barr virus-positive inflammatory cells in the bite lesion.
We describe a unique patient with mosquito-bite hypersensitivity who had extremely high titres of Epstein-Barr virus antibodies. For many years he developed intractable ulcers on the sites of mosquito-bite. Epstein-Barr virus infection was detected in almost all inflammatory cells in the ulcers and in the peripheral blood lymphocytes by using in situ hybridization to Epstein-Barr virus-encoded small ribonucleic acids and by polymerase chain reaction to Epstein-Barr virus DNA. The inflammatory cells in the ulcers were positive for T-cell marker. Our results suggest that the Epstein-Barr virus infection in T cells may participate in the pathogenesis of exaggerated mosquito hypersensitivity and in delayed healing of ulcers on the sites of mosquito-bite.
Ohsawa
T
T
Department of Dermatology, Faculty of Medicine, Tottori University, Yonago, Japan.
Morimura
T
T
Hagari
Y
Y
Kawakami
T
T
Mihara
M
M
Hirai
K
K
Ikuta
K
K
Murakami
M
M
Sairenji
T
T
Matsuse
T
T
D000293:Adolescent; D000818:Animals; D009033:Culicidae; D004279:DNA, Viral / Q000302:isolation & purification; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D007299:Insect Bites and Stings / Q000150:complications* / Q000276:immunology / Q000473:pathology; D007871:Leg Ulcer / Q000209:etiology* / Q000473:pathology / Q000821:virology; D008297:Male; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000821:virology*
D004279:DNA, Viral