title: New method of synthesis of Vinca alkaloid derivatives.
abstract: Vinblastine and vinorelbine analogues have been synthesised by reacting new versatile electrophilic vindoline derivatives with various 3-substituted indoles. The resulting compounds have been evaluated for their antimitotic properties, but exhibited less potent activities in comparison with the standard binary Vinca alkaloids.
authors.affiliation: Division de Chimie Médicinale V, Centre de Recherche Pierre Fabre, 81106 Castres, France. jacques.fahy@pierre-fabre.com
authors.forename: Jacques
authors.initials: J
authors.lastname: Fahy
authors.forename: Valérie
authors.initials: V
authors.lastname: Thillaye du Boullay
authors.forename: Dennis C H
authors.initials: DC
authors.lastname: Bigg
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D050257:Tubulin Modulators; D014748:Vinca Alkaloids / Q000138:chemical synthesis*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D050257:Tubulin Modulators; D014748:Vinca Alkaloids