title: [Molecular bases for brucella virulence].
abstract: The authors review published reports on the molecular bases of Brucella virulence, including type IV secretion proteins, S-lipopolysaccharide biosynthesis enzymes (O-antigen), regulatory proteins of various systems, and cellular metabolism proteins. High efficiency of modified transposon mutagenesis technique (selective labeled transposon mutagenesis) in search for virulence genes is shown. Analysis of DNA sequences of Brucella genome promotes identification of new virulence factors.
authors.affiliation: N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences.
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Kulakov
authors.forename: M M
authors.initials: MM
authors.lastname: Zheludkov
mesh_terms: D001426:Bacterial Proteins / Q000502:physiology; D002002:Brucella / Q000235:genetics / Q000472:pathogenicity*; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D016680:Genome, Bacterial; D016296:Mutagenesis; D014774:Virulence / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D004269:DNA, Bacterial