title: [Baroreflex failure syndrome: an uncommon case of an extreme blood pressure variability].
abstract: BACKGROUND
  The arterial baroreflex operates in physiological conditions. It induces sympathetic and vagal activity modulation resulting in arterial tone and heart rate changes. These appropriate responses limit blood pressure fluctuations and blood pressure is therefore regulated since the baroreflex constantly buffers the changes.
  
  
  METHODS
  Bilateral carotid body tumor excision resulted in excessive fluctuations of blood pressure. Indices of spontaneous baroreflex activity were markedly altered in the patient described herein.
  
  
  CONCLUSIONS
  The excessive fluctuations of blood pressure due to the sinoaortic denervation demonstrate how powerful is this negative feedback control mechanism in control conditions.
authors.affiliation: Pharmacologie clinique, néphrologie adultes, hôpital Necker, 149, rue de Sèvres, 75015 Paris, France. elghozi@necker.fr
authors.forename: J L
authors.initials: JL
authors.lastname: Elghozi
authors.forename: A
authors.initials: A
authors.lastname: Girard
authors.forename: J
authors.initials: J
authors.lastname: Ribstein
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure; D002345:Carotid Body Tumor / Q000175:diagnosis / Q000601:surgery*; D003000:Clonidine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011187:Posture; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D003000:Clonidine