Effects of anti-inflammatory steroid drugs on pain coping behaviours in a model of articular pain in the domestic fowl.
The optimum dose rates of betamethasone, dexamethasone (sodium phosphate) and methylprednisolone (acetate salt) were determined for the treatment of inflammatory pain in domestic fowl using the microcrystalline sodium urate model of articular pain. The response criteria were the changes in behavioural profiles and pain-related activity over 60 minutes commencing 1 hour after an intra-articular injection of sodium urate and a course of intramuscular injections of a range of doses of each drug on the previous 2 days. The optimum dose rates for betamethasone, dexamethasone and methylprednisolone respectively were 0.04, 0.06 and 2 mg kg(-1)and are in the range of the recommended doses for these drugs in mammals.
Hocking
P M
PM
Roslin Institute (Edinburgh), Roslin, Midlothian, EH25 9PS, Scotland, UK. paul.hocking@bbsrc.ac.uk
Robertson
G W
GW
Gentle
M J
MJ
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001623:Betamethasone / Q000494:pharmacology / Q000627:therapeutic use; D002645:Chickens; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000188:drug therapy / Q000662:veterinary*; D007270:Injections, Intra-Articular / Q000662:veterinary; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy / Q000662:veterinary*; D011201:Poultry Diseases / Q000188:drug therapy*; D011897:Random Allocation
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D001623:Betamethasone; D008775:Methylprednisolone