[Effect of yimai jiangya extract on platelet activation and fibrinolytic activity and angiotensin II in aged patients with essential hypertension].
OBJECTIVE
To observe the effect of Yimai Jiangya extract (YMJYE) on platelet alpha-granule membrane protein (GMP-140), tissue-type plasminogen activator (t-PA) and its inhibitor (PAI), angiotensin II (AngII) in aged patients with essential hypertension (EH) of stage 2 caused by Qi deficiency and blood stasis.


METHODS
Radioimmunoassay (RIA) and colorimetric analysis were used to examine the levels of GMP-140, t-PA, PAI and AngII before and after treatment with YMJYE in 42 aged patients (treated group), compared with that of 30 aged patients before and after treatment with captopril (control group) and 30 aged healthy subjects (healthy group).


RESULTS
Before treatment, GMP-140, PAI and AngII were significantly higher (P < 0.01), and t-PA were obviously lower (P < 0.01) in the treated and the control group compared with those in the healthy group. After treatment, the improvement of GMP-140, t-PA, PAI and AngII in the treated group were obvious (P < 0.05, P < 0.01). The improvement of GMP-140, t-PA, PAI in the treated group was more significant than that of control group (P < 0.05, P < 0.01), while the improvement of AngII in the treated group was worse than that of the control group (P < 0.01). After treatment, there was insignificant changes about the levels of blood pressure between the treated group and the control group (P > 0.05).


CONCLUSIONS
In the aged patients, GMP-140, PAI and AngII were increased, t-PA reduced. The effects of YMJYE in inhibiting platelet activation and improving fibrinolytic activity were better than that of captopril. These findings indicated that the mechanisms of inhibiting platelet activation and improving fibrinolytic activity and lowering blood pressure of YMJYE were correlated with decreasing the levels of AngII, but other mechanisms may also exist.
Duan
X
X
Jinan Military Regional General Hospital, Jinan (250031).
Yang
D
D
Sun
X
X
D000368:Aged; D000804:Angiotensin II / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects*; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D019007:P-Selectin; D017395:Plasminogen Activator Inhibitor 1; D000804:Angiotensin II; D010959:Tissue Plasminogen Activator