Oral administration of sodium selenite minimizes cisplatin toxicity on proximal tubules of rats.
Cisplatin (c-DDP) is a widely used antineoplastic drug whose main side effect is nephrotoxicity. Selenium, administered intravenously or intraperitoneally, has been shown to provided protection against c-DDP-induced nephrotoxicity in rats. In the present study, the protective effect of orally administered sodium selenite on c-DDP toxicity was further examined. Animals treated with c-DDP alone showed increased urinary volume, decreased creatinine clearance (GFR), and a rise in urinary N-acetyl-(beta-D-glucosaminidase) (NAG) isoenzyme B activity. When sodium selenite was given prior to c-DDP, rats showed less GFR decline, delayed urinary volume increases, and no urinary NAG isoenzyme B activity increment. It is suggested that a single oral dose of sodium selenite given prior to c-DDP administration, although not preventing deterioration of renal function, partially protects rats from early proximal tubular injury.
Camargo
S M
SM
Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Science of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Francescato
H D
HD
Lavrador
M A
MA
Bianchi
M L
ML
D000118:Acetylglucosaminidase / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D003404:Creatinine / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000494:pharmacology*
D000970:Antineoplastic Agents; D007527:Isoenzymes; D003404:Creatinine; D000118:Acetylglucosaminidase; D018038:Sodium Selenite; D002945:Cisplatin