[Studies on infiltration mechanism of adenoid cystic carcinoma: haptotaxis function assay of fibronectin].
OBJECTIVE
To investigate the invasion mechanism of adenoid cystic carcinoma (ACC) by ACC haptotaxis changes in fibronectin (FN).


METHODS
Three strains of ACC cells were used. The haptotaxis changes in FN, and receptor changes in the cell membrane surface were determined.


RESULTS
All three strains of ACC cells had remarkably greater migration ability than SCC cell. High level of alpha 2, alpha 3, alpha 6 and beta 1 receptor subunit types was found in the cell surface of ACC and SCC; and high level of alpha 5 in ACC3. High inhibition of haptotaxis reaction was found after blocked alpha 5 and beta 1 receptor subunit in ACC and a middle inhibition after blocked alpha 4. In SCC more strong inhibition was found after blocked alpha 1, alpha 4 and beta 1.


CONCLUSIONS
This study indicates that ACC cells have greater invasion ability than SCC cells in FN and haptotaxis reaction of different receptor of tested cells in FN have some feature pattern.
Li
C
C
Department of Oral Pathology, Beijing Hospital for Stomatology, Capital University of Medical Sciences, Beijing 100050, China.
Su
Y
Y
Gao
Y
Y
D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D005353:Fibronectins / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness
D005353:Fibronectins