title: Incremental cost-effectiveness of laser therapy for visual loss secondary to branch retinal vein occlusion.
abstract: OBJECTIVE
  To ascertain the incremental cost-effectiveness of therapeutic interventions for improving visual loss associated with branch retinal vein occlusion.
  
  
  METHODS
  A cost-utility analysis incorporating data from the Branch Vein Occlusion Study Group was performed using patient-based preferences obtained from time tradeoff utility analysis, decision analysis with Markov modeling, and economic modeling with future value analysis. The cost-effectiveness results are expressed in dollars/QALY (dollars expended per quality-adjusted life-year) gained. This unique model takes into account the visual acuity in the better seeing eye and the recurrent risk for visual loss in the contralateral eye.
  
  
  RESULTS
  Laser therapy for macular edema secondary to branch retinal vein occlusion was associated with an incremental dollars/QALY gained of 6118 dollars (in year 2000 U.S. dollars). Two-way sensitivity analysis, varying the discount rate and the proportion of patients developing a vascular occlusion in the contralateral eye, revealed a range of dollars/QALY gained from 3370 dollars to 19,299 dollars.
  
  
  CONCLUSIONS
  Laser therapy appears to be a cost-effective intervention for improving visual loss associated with macular edema secondary to branch retinal vein occlusion. Variants of the methodology employed to calculate the incremental cost-effectiveness of this intervention can be widely applied across all specialties in medicine.
authors.affiliation: Center for Evidence-Based Health Care Economics, Flourtown, PA 19031, USA. Garyo514@aol.com
authors.forename: Gary C
authors.initials: GC
authors.lastname: Brown
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Brown
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sharma
authors.forename: Brandon
authors.initials: B
authors.lastname: Busbee
authors.forename: Heidi
authors.initials: H
authors.lastname: Brown
mesh_terms: D000368:Aged; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D003695:Delivery of Health Care / Q000191:economics; D006302:Health Services Research; D006801:Humans; D017075:Laser Coagulation / Q000191:economics*; D008017:Life Expectancy; D008269:Macular Edema / Q000191:economics* / Q000209:etiology / Q000601:surgery; D008390:Markov Chains; D018803:Models, Economic; D017060:Patient Satisfaction; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012170:Retinal Vein Occlusion / Q000150:complications / Q000191:economics* / Q000601:surgery; D014786:Vision Disorders / Q000191:economics* / Q000209:etiology / Q000601:surgery; D014792:Visual Acuity