Massive intracerebral aspergillosis responding to combination high dose liposomal amphotericin B and cytokine therapy without surgery.
This report describes a patient with intracranial Aspergillus flavus infection in whom it was impossible to remove the fungal mass surgically. Progressive fungal infiltration of the optic nerves was reversed and the extensive intracranial fungal burden was managed successfully with combination antifungal-immunomodulatory therapy alone.
Ellis
M
M
Watson
R
R
Departments of Medicine and ‡Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain and Departments of *Surgery, †Medicine and §Radiology, Tawam Hospital, Al Ain, UAE.
McNabb
A
A
Departments of Medicine and ‡Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain and Departments of *Surgery, †Medicine and §Radiology, Tawam Hospital, Al Ain, UAE.
Lukic
M L
ML
Departments of Medicine and ‡Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain and Departments of *Surgery, †Medicine and §Radiology, Tawam Hospital, Al Ain, UAE.
Nork
M
M
Departments of Medicine and ‡Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain and Departments of *Surgery, †Medicine and §Radiology, Tawam Hospital, Al Ain, UAE.
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000473:pathology; D001231:Aspergillus flavus / Q000187:drug effects / Q000254:growth & development*; D001927:Brain Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016207:Cytokines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008081:Liposomes; D008279:Magnetic Resonance Imaging
D000935:Antifungal Agents; D016207:Cytokines; D008081:Liposomes; D000666:Amphotericin B