Antiandrogens in the treatment of priapism.
Recurrent priapism in young men is a potentially devastating condition that may result in irreversible penile fibrosis. Hormonal manipulation using estrogens and gonadotropin-releasing hormone analogues has been successful in treating episodes of priapism refractory to other treatment forms, but it is associated with significant adverse effects, in particular the loss of libido and erectile function. We present 2 patients with sickle-cell disease and 1 patient with a spinal cord injury who had recurrent and refractory priapism. All 3 patients were successfully treated with low-dose antiandrogens without major side effects. Our observations suggest a role for antiandrogens in the treatment of men with refractory priapism that should be evaluated in the setting of a controlled study.
Dahm
Philipp
P
Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
Rao
Dinesh S
DS
Donatucci
Craig F
CF
D000328:Adult; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000813:Anilides / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D009570:Nitriles; D011317:Priapism / Q000188:drug therapy*; D014105:Tosyl Compounds
D000726:Androgen Antagonists; D000813:Anilides; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide