[Effect of kidney replenishing Chinese herbs on insulin-like growth factor-1 and its receptor in androgen induced sterile rats].
OBJECTIVE
To observe the effect of Kidney replenishing Chinese herbs (KRCH) on insulin-like growth factor-1 and its receptor (IGF-1/IGF-1R) in androgen induced sterile rats (ASR).


METHODS
ASR model was set up and screened by vaginal smear. The level of serum IGF-1 was detected by radioimmunoassay, and IGF-1R by immunohistochemical method.


RESULTS
(1) Serum IGF-1 level in model rats group > model rats treated with KRCH group > normal control group, but no statistical difference was found among them. KRCH could lower the level of serum IGF-1. (2) Level of IGF-1R in pancreas, liver, ovary and adrenal gland showed an opposite sequence to that of serum IGF-1.


CONCLUSIONS
ASR shows a high IGF-1 level in serum and low IGF-1R level in main target organs, and KRCH could adjust the levels in certain degree. From this, it is inferred that the ovulation effect of KRCH on ASR may come true partly by adjusting the level of IGF-1/IGF-1R.
Li
G
G
Obstetric and Gynecology Hospital, Shanghai Medical University, Shanghai (200011).
Gui
S
S
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007247:Infertility, Female / Q000097:blood* / Q000139:chemically induced; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017526:Receptor, IGF Type 1 / Q000097:blood*; D013739:Testosterone
D004365:Drugs, Chinese Herbal; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1