title: Serum zinc, chromium, and iron concentrations in dogs with lymphoma and osteosarcoma.
abstract: We compared serum concentrations of zinc, chromium, and iron in dogs with cancer to those of normal dogs. Dogs with lymphoma (n = 50) and osteosarcoma (n = 52) were evaluated. Dogs with lymphoma had significantly lower (P = .0028) mean serum zinc concentrations (mean +/- SD; 1.0 +/- 0.3 mg/L) when compared to normal dogs (1.2 +/- 0.4 mg/L). Dogs with osteosarcoma also had lower mean serum zinc concentrations (1.1 +/- 0.4 mg/L), but this difference was not significant (P = .075). Serum chromium concentrations were significantly lower in dogs with lymphoma (2.6 +/- 2.6 microg/L, P = .0007) and osteosarcoma (2.4 +/- 3.1 microg/L, P = .0001) compared to normal dogs (4.7 +/- 2.8 microg/L). Serum iron concentrations and total iron-binding capacity were significantly lower in dogs with lymphoma (110.8 +/- 56.7 microg/dL, P < .0001, and 236.6 +/- 45.6 microg/dL, P < .0001, respectively) and osteosarcoma (99.6 +/- 49.3 microg/dL, P < .0001, and 245.0 +/- 43.8 microg/dL, P = .0011, respectively) when compared to normal dogs (175.1 +/- 56.7 microg/dL and 277.1 +/- 47.4 microg/dL). Mean ferritin concentration was significantly higher in dogs with lymphoma (1291.7 +/- 63.0 microg/L) than in normal dogs (805.8 +/- 291.1 microg/L, P < .0001) and dogs with osteosarcoma (826.5 +/- 309.2 microg/L, P < .0001). Further investigation is needed to explore the clinical significance of these mineral abnormalities in dogs with cancer.
authors.affiliation: Animal Cancer Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, USA. kkazmier@vth.colostate.edu
authors.forename: K J
authors.initials: KJ
authors.lastname: Kazmierski
authors.forename: G K
authors.initials: GK
authors.lastname: Ogilvie
authors.forename: M J
authors.initials: MJ
authors.lastname: Fettman
authors.forename: S E
authors.initials: SE
authors.lastname: Lana
authors.forename: J A
authors.initials: JA
authors.lastname: Walton
authors.forename: R A
authors.initials: RA
authors.lastname: Hansen
authors.forename: K L
authors.initials: KL
authors.lastname: Richardson
authors.forename: D W
authors.initials: DW
authors.lastname: Hamar
authors.forename: C L
authors.initials: CL
authors.lastname: Bedwell
authors.forename: G
authors.initials: G
authors.lastname: Andrews
authors.forename: S
authors.initials: S
authors.lastname: Chavey
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology / Q000662:veterinary*; D016022:Case-Control Studies; D002857:Chromium / Q000097:blood* / Q000172:deficiency; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D005951:Glucose Tolerance Test / Q000662:veterinary; D006946:Hyperinsulinism / Q000662:veterinary; D007501:Iron / Q000097:blood*; D007694:Killer Cells, Natural; D008223:Lymphoma / Q000473:pathology / Q000662:veterinary*; D008297:Male; D012516:Osteosarcoma / Q000473:pathology / Q000662:veterinary*; D015032:Zinc / Q000097:blood* / Q000172:deficiency
chemical_list: D002857:Chromium; D007501:Iron; D015032:Zinc