Sjögren's syndrome: immunological response underlying the disease.
Sjögren's syndrome is a chronic autoimmnune disorder characterized primarily by the discomforts od dry eyes and dry mouth due to the progressive loss of exocrine gland function. Development of a number of animal models to study Sjögren's syndrome, especially the NOD mouse and its congenic partner strains, has permitted a systematic analysis of immunological and non-immunological factors that influence predisposition for development of the autoimmune response. These data are reviewed here.
Brayer
J B
JB
Department of Oral Biology, University of Florida, Gainesville 32610, USA.
Humphreys-Beher
M G
MG
Peck
A B
AB
D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D015870:Gene Expression; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D019463:Mice, Inbred MRL lpr; D016688:Mice, Inbred NOD; D018345:Mice, Knockout; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012859:Sjogren's Syndrome / Q000209:etiology / Q000235:genetics / Q000276:immunology*
D016207:Cytokines; D012333:RNA, Messenger