Hepatic failure due to CD3+ plasma cell infiltration of the liver in multiple myeloma.
We present a case of multiple myeloma who died of liver failure 7.5 months after initial diagnosis. Postmortem liver biopsy revealed diffuse CD3-expressing plasma cell infiltration and eosinophilic amorphous material deposition which was considered as light chain deposits. T cell receptor-gamma rearrangement was not detected in liver biopsy sections using the polymerase chain reaction despite CD3 positivity. To our knowledge, this is the first report of CD3-expressing plasma cell infiltration in tissue sections. The discordance between the phenotype and the genotype suggests a partial activation of genes encoding the T cell antigens by the transforming event. We also concluded that CD3 positivity was associated with short survival, which is consistent with previous data.
Yağcí
Münci
M
Department of Haematology, Gazi Medical School, Gazi University, TR-06610 Ankara, Turkey. erhem@med.gazi.edu.tr
Sucak
Gülsan Türköz
GT
Akyol
Gülen
G
Haznedar
Rauf
R
D000368:Aged; D017252:CD3 Complex / Q000378:metabolism*; D002465:Cell Movement; D004804:Eosinophils / Q000473:pathology; D017809:Fatal Outcome; D019675:Genes, T-Cell Receptor gamma; D006801:Humans; D017093:Liver Failure / Q000209:etiology* / Q000473:pathology; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology* / Q000473:pathology
D017252:CD3 Complex