title: Configuration space analysis of common cost functions in radiotherapy beam-weight optimization algorithms.
abstract: The successful implementation of downhill search engines in radiotherapy optimization algorithms depends on the absence of local minima in the search space. Such techniques are much faster than stochastic optimization methods but may become trapped in local minima if they exist. A technique known as 'configuration space analysis' was applied to examine the search space of cost functions used in radiotherapy beam-weight optimization algorithms. A downhill-simplex beam-weight optimization algorithm was run repeatedly to produce a frequency distribution of final cost values. By plotting the frequency distribution as a function of final cost, the existence of local minima can be determined. Common cost functions such as the quadratic deviation of dose to the planning target volume (PTV), integral dose to organs-at-risk (OARs), dose-threshold and dose-volume constraints for OARs were studied. Combinations of the cost functions were also considered. The simple cost function terms such as the quadratic PTV dose and integral dose to OAR cost function terms are not susceptible to local minima. In contrast, dose-threshold and dose-volume OAR constraint cost function terms are able to produce local minima in the example case studied.
authors.affiliation: Joint Department of Physics, Institute of Cancer Research and the Royal Marsden NHS Trust, Sutton, Surrey, UK. carl.rowbottom@physics.org
authors.forename: Carl Graham
authors.initials: CG
authors.lastname: Rowbottom
authors.forename: Steve
authors.initials: S
authors.lastname: Webb
mesh_terms: D000465:Algorithms; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D011878:Radiotherapy / Q000191:economics* / Q000379:methods*; D012984:Software