Postnatal changes in maternal and neonatal plasma antioxidant vitamins and the influence of smoking.
OBJECTIVE
To study the postnatal changes in the plasma concentrations of fat soluble antioxidant vitamins and malondialdehyde (MDA) in mothers and their newborns and their relation to smoking.


METHODS
Prospective cohort study.


METHODS
Tertiary perinatal centre.


METHODS
Eighteen non-smoking and 14 smoking mothers and 33 infants.


METHODS
Plasma concentrations of vitamins E, A, and beta-carotene and MDA were measured in mothers and infants at delivery and on day 4 post partum.


RESULTS
Neonatal plasma levels of vitamins E, A, and beta-carotene were significantly lower than maternal levels both at delivery and on day 4 in both groups. There was a significant postnatal increase in plasma vitamin E levels in smoking mothers and neonates of both groups. A significant postnatal increase in maternal, but not neonatal, plasma vitamin A was noted in both groups. Cord plasma vitamin E levels were significantly lower in infants of smoking mothers (mean 4.7 v 6.5 micromol/l, p = 0.041). Plasma MDA was paradoxically lower in smoking mothers at delivery (3.19 v 4.01 micromol/l, p = 0.03) and on day 4 (1.37 v 3.29 micromol/l, p = 0.005) and in infants of the smoking group on day 4 (2.18 v 3.12 micromol/l, p = 0.014). Also, there was a significant postnatal fall in plasma MDA levels on day 4 in mothers and infants in the smoking group.


CONCLUSIONS
The postnatal changes in plasma vitamin E were more pronounced in the smoking group. The postnatal changes in plasma vitamins A and beta-carotene were similar in both groups. The rapid decline in plasma MDA in smoking mothers and their infants suggests withdrawal of oxidative stress from smoking around delivery. This coincided with the increase in plasma vitamin E.
Bolisetty
S
S
Kirwan Hospital For Women, Townsville, Queensland, Australia. srinib75@hotmailcom
Naidoo
D
D
Lui
K
K
Koh
T H H G
TH
Watson
D
D
Montgomery
R
R
Whitehall
J
J
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D004032:Diet; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008431:Maternal-Fetal Exchange / Q000502:physiology; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D012907:Smoking / Q000097:blood*; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D014815:Vitamins / Q000097:blood*; D019207:beta Carotene / Q000097:blood
D000975:Antioxidants; D014815:Vitamins; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde