Pneumonia and sepsis due to fluoroquinolone-resistant Capnocytophaga gingivalis after autologous stem cell transplantation.
Human oral Capnocytophaga species have been only rarely described as a cause of sepsis in patients following stem cell or marrow transplantation, and pneumonia has not been reported in this setting. In addition, fluoroquinolone resistance is rarely seen in these species, and has never been reported in C. gingivalis. We report a case of pneumonia (confirmed by culture of bronchoalveolar lavage fluid) and sepsis due to fluoroquinolone- resistant Capnocytophaga gingivalis in a patient following autologous stem cell transplantation, who responded to treatment with linezolid and metronidazole. Capnocytophaga infections should be considered in patients with fever following stem cell or marrow transplantation, especially those with neutropenia and mucositis. Susceptibility testing is needed given the existence of multidrug-resistant isolates.
Geisler
W M
WM
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA.
Malhotra
U
U
Stamm
W E
WE
D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002206:Capnocytophaga / Q000187:drug effects / Q000302:isolation & purification*; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones; D016905:Gram-Negative Bacterial Infections / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial / Q000209:etiology*; D018805:Sepsis / Q000209:etiology*; D014182:Transplantation, Autologous
D000890:Anti-Infective Agents; D024841:Fluoroquinolones