Activity of glutathione-s-transferase, gammaglutamiltransferase and catalase in the erythrocytic membrane in arterial hypertension.
Our clinical-biological study has been performed in patients with various clinical forms of arterial hypertension (AHT), as well as with sequelae-type complications from stroke that had occurred during the evolution of the disease. We performed biological determinations of the activity of four erythrocytic enzymes: glutathione-s-transferase (GST), catalase, gamma-glutamyltransferase (GGT), and lactate dehydrogenase (LDH). The results point to the existence of individual values and also of important differences depending on the presence of arterial hypertension complications. We found a moderate but significant increase of erythrocytic GGT in hypertensive patients compared to healthy controls. Erythrocytic GST and LDH were decreased in patients vs controls. The results of the enzymatic, erythrocyitc activities of GST, GGT, catalase and LDH can also be correlated with the parameters of erythrocyitc membrane permeability and with the thiolic groups, fibrinogen and ionic calcium concentration. The data described in this paper suggest the possible involvement of the disturbances mentioned above in the etiopathogeny of AHT.
Balta
N
N
D. Danielopolu Institute of Normal and Pathological Physiology, Bucharest, Romania.
Gatina
R
R
Ioan
M
M
Burtea
C
C
Moisin
C
C
Teleianu
C
C
Petolea
S
S
D000328:Adult; D002374:Catalase / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000502:physiology; D004910:Erythrocyte Membrane / Q000201:enzymology* / Q000378:metabolism; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D007770:L-Lactate Dehydrogenase; D002374:Catalase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase