title: Humoral immune response to allograft valve tissue pretreated with an antigen reduction process.
abstract: The humoral immune response to allograft heart valves as measured by PRA was absent in 52 of 57 (91%) patients at 1 month and was absent in 43 of 49 (88%) at 3 months in allograft valves treated with the SynerGraft process for antigen reduction. Short-term valve function is satisfactory. This may be associated with improved durability and long-term function.
authors.affiliation: Section of Thoracic and Cardiovascular Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Elkins
authors.forename: M M
authors.initials: MM
authors.lastname: Lane
authors.forename: S B
authors.initials: SB
authors.lastname: Capps
authors.forename: C
authors.initials: C
authors.lastname: McCue
authors.forename: P E
authors.initials: PE
authors.lastname: Dawson
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000917:Antibody Formation / Q000276:immunology; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000276:immunology* / Q000637:transplantation; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation; D005260:Female; D006082:Graft Enhancement, Immunologic; D006349:Heart Valve Diseases / Q000601:surgery; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011664:Pulmonary Valve / Q000000981:diagnostic imaging / Q000276:immunology* / Q000637:transplantation; D014184:Transplantation, Homologous / Q000276:immunology*; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; D015395:Histocompatibility Antigens Class I