[Statins in the treatment of patients with arterial occlusive disease of the lower extremities].
In patients with advanced atherosclerosis manifested by arterial occlusion in the lower extremities without a baseline blood lipid disorder statin treatment caused improvement of the efficiency, i.e. prolongation of the claudication interval, while in a comparable control group without statins the efficiency deteriorated further. In patients with arterial occlusion of the lower extremities with baseline dyslipidaemia statin treatment proved protective, i.e. at least it retarded the patients' complaints. The authors recorded improvement of the prooxidation state which followed after the dynamics of improvement of the impaired blood lipid spectrum. The results admit a possible part played by the pleiotropic effect of statins.
Mayer
O
O
Oddĕlení klinické farmakologie FN, Plzen.
Hromádka
M
M
D000328:Adult; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007383:Intermittent Claudication / Q000209:etiology; D007866:Leg / Q000098:blood supply*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019821:Simvastatin / Q000627:therapeutic use*
D000960:Hypolipidemic Agents; D008055:Lipids; D019821:Simvastatin