The effect of loratadine in exercise-induced asthma.
OBJECTIVE
To assess the effect of loratadine in exercise induced asthma.


METHODS
Randomised, double blind, placebo controlled study of 10 mg oral loratadine, once daily for three days in 11 children. At the end of the treatment period FEV(1) was measured, and patients were exercised on a treadmill. FEV(1) measurements were repeated at intervals after exercise.


RESULTS
Loratadine significantly reduced the decrease in FEV(1) after exercise at two, five, 10, 15, and 30 minutes, compared with placebo (p < 0.05). However, the mean decrease in FEV(1) at five minutes was more than 15% of baseline in the loratadine group.


CONCLUSIONS
Loratadine reduces, but does not prevent, exercise induced asthma in children.
Baki
A
A
Department of Paediatrics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Orhan
F
F
D000293:Adolescent; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D002648:Child; D004311:Double-Blind Method; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D017336:Loratadine / Q000627:therapeutic use*; D008297:Male; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D006634:Histamine H1 Antagonists; D017336:Loratadine