title: Pediatric acute hemorrhagic leukoencephalitis: report of a surviving patient and review.
abstract: Acute hemorrhagic leukoencephalitis (AHLE) is a rare, fulminant CNS demyelinating condition usually diagnosed at autopsy. We report the clinical, laboratory, radiographic, and pathologic features of the first nonfatal case of pediatric AHLE confirmed by brain biopsy. Pathologic diagnosis of this condition may be critical to exclude more-common processes and to expedite the decision to administer high-dose corticosteroid therapy, which is potentially lifesaving.
authors.affiliation: Division of Infectious Diseases, Children's Hospital and Health Center, San Diego, CA, 92123, USA. jleake@chsd.org
authors.forename: John A D
authors.initials: JA
authors.lastname: Leake
authors.forename: Glenn F
authors.initials: GF
authors.lastname: Billman
authors.forename: Mark P
authors.initials: MP
authors.lastname: Nespeca
authors.forename: Susan E
authors.initials: SE
authors.lastname: Duthie
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Dory
authors.forename: Hal S
authors.initials: HS
authors.lastname: Meltzer
authors.forename: John S
authors.initials: JS
authors.lastname: Bradley
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000893:Anti-Inflammatory Agents