title: Prevalence of circulating antibodies to p10, a non-structural protein of the Borna disease virus in cats with ataxia.
abstract: Japanese domestic cats were surveyed for circulating antibodies to the plO and p24 proteins of the Borna disease virus (BDV) by Western blotting. Twenty-four of 52 cats (46.2%) with ataxia and other neurologic symptoms of unknown cause were positive for antibodies to BDV p10 and/or p24. In contrast, cats without neurological symptoms gave a significantly lower prevalence of anti-BDV antibodies to p10 and/or p24 (36 of 152 cats, 23.7%). Thirty specific pathogen-free (SPF) cats tested as controls were uniformly negative to BDV pl0 and p24 antigens. These results suggest that BDV may play a role in ataxia in cats. Additionally, our results suggest that it is necessary to use both p10 and p24 as antigens to detect circulating antibodies to BDV in cats.
authors.affiliation: Tsukuba Central Laboratories, Kyoritsu Seiyaku Corporation, Inashiki-gun, Ibaraki, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ouchi
authors.forename: M
authors.initials: M
authors.lastname: Kishi
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: P K
authors.initials: PK
authors.lastname: Lai
authors.forename: T H
authors.initials: TH
authors.lastname: Malik
authors.forename: K
authors.initials: K
authors.lastname: Ikuta
authors.forename: M
authors.initials: M
authors.lastname: Mochizuki
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001259:Ataxia / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D001890:Borna Disease / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D001891:Borna disease virus / Q000276:immunology*; D002371:Cat Diseases / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D002415:Cats; D005260:Female; D007564:Japan / Q000453:epidemiology; D008297:Male; D016036:Seroepidemiologic Studies; D013047:Specific Pathogen-Free Organisms; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014764:Viral Proteins; C119397:p10 protein, Borna disease virus