Novel signaling pathway through the beta-adrenergic receptor.
beta -Adrenergic receptors transduce signals through the heterotrimeric G protein Galphas to regulate cardiac function. Recently, it has been discovered that Galphas could directly stimulate the Src family tyrosine kinase activity. This novel signaling pathway provides insights into the cAMP-PKA-independent signaling mechanisms used by beta -adrenergic receptors to regulate apoptosis, receptor desensitization, and other physiological functions.
Ma
Yong Chao
YC
Department of Physiology, Weill Medical College of Cornell University, New York, NY 10021, USA.
Huang
Xin Yun
XY
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D015398:Signal Transduction; D019061:src-Family Kinases / Q000502:physiology*
D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D019061:src-Family Kinases; D019204:GTP-Binding Proteins