title: 3D-biohybrid systems: applications in drug screening.
abstract: Biotechnology demands powerful methods for the functional characterisation and monitoring of molecular alterations in tissues in response to various stimuli. Currently, cellular biosensors provide information about cell and tissue internal transduction pathways. In this article, recent biosensor systems are briefly described and the use of 3D tissue aggregates as recognition elements is discussed. An example of an innovative approach for drug testing using 3D heart muscle aggregates, as well as tumor models, positioned in capillary systems for electrical potential recording and impedance measurement is described. The effectiveness of drugs and therapies can be tested and monitored in a short time using such biohybrid sensors.
authors.affiliation: Fraunhofer Institute for Biomedical Engineering (FhG-IBMT), Department of Biohybrid Systems, Ensheimer Str. 48, 66386 St Ingbert/Saar, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Reininger-Mack
authors.forename: Hagen
authors.initials: H
authors.lastname: Thielecke
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Robitzki
mesh_terms: D000200:Action Potentials; D000818:Animals; D015374:Biosensing Techniques / Q000379:methods* / Q000639:trends; D002196:Capillaries / Q000166:cytology / Q000502:physiology; D004353:Drug Evaluation, Preclinical / Q000379:methods* / Q000639:trends; D017097:Electric Impedance; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D016896:Treatment Outcome