Interaction between cisplatin, 5-fluorouracil and vincristine on human hepatoma cell line (7721).
AIM:To evaluate the killing effects of CDDP, 5-Fu and VCR on human hepaoma cell line (7721).METHODS:The median-effect principle was used.RESULTS:Killing effects of the individual drug were enhanced as the median concentration increased. Antagonism was produced when two drugs were used at a higher concentration (CI > 1), and synergism was achiened when CI < 1. Finally, the effect was influenced by both the ratios of drug concentration and the sequence of administration.CONCLUSION:The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.
Tang
Wei-Xue
WX
Cheng
Ping-Yan
PY
Luo
Yun-Peng
YP
Wang
Rui-Xue
RX