Cellular senescence and matrix metalloproteinase activity in chronic wounds. Relevance to debridement and new technologies.
A prolonged inflammatory response may adversely affect wound closure. Delayed wound closure and extended exposure to chronic wound fluid may also affect cellular activity in a wound bed and result in cellular senescence. Prolonged inflammation and cellular senescence may adversely affect the efficacy of topically-applied biological agents, including growth factors. Appropriate wound bed preparation and debridement are necessary to improve clinical outcomes of new technologies.
Mulder
Gerit D
GD
University of California San Diego Medical Center, Regional Burn Center/Wound Treatment and Research Center, 200 W Arbor Dr 8896, San Diego, CA 92103-8896, USA.
Vande Berg
Jerry S
JS
D002908:Chronic Disease; D003646:Debridement / Q000379:methods; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D011032:Podiatry / Q000379:methods; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000628:therapy*
D020782:Matrix Metalloproteinases