title: A quantitative trait locus influencing activin-to-estrogen ratio in pedigreed baboons maps to a region homologous to human chromosome 19.
abstract: Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome 19p13.2, showed marginal evidence of linkage with a lod (log10 of the odds in favor of genetic linkage) score of 1.95 (0.014). This region contains several potential candidate genes including PKA (protein kinase, cAMP-dependent, catalytic alpha) and the gene pair JUN-B and JUN-D. This is the first evidence of a quantitative trait locus with a significant effect on the activin-to-estrogen ratio.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Martin
authors.forename: J
authors.initials: J
authors.lastname: Blangero
authors.forename: J
authors.initials: J
authors.lastname: Rogers
authors.forename: M C
authors.initials: MC
authors.lastname: Mahaney
authors.forename: J E
authors.initials: JE
authors.lastname: Hixson
authors.forename: K D
authors.initials: KD
authors.lastname: Carey
authors.forename: A G
authors.initials: AG
authors.lastname: Comuzzie
mesh_terms: D028341:Activins / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D004967:Estrogens / Q000097:blood / Q000378:metabolism*; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D006801:Humans; D008126:Lod Score; D018895:Microsatellite Repeats / Q000235:genetics; D008957:Models, Genetic; D010215:Papio / Q000097:blood / Q000235:genetics* / Q000378:metabolism*; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics; D019655:Quantitative Trait, Heritable; D011863:Radioimmunoassay; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004967:Estrogens; D028341:Activins