Elucidation of tumor-promoting potential of a combination pesticide by short-term, in vivo bioassay.
The use of combination pesticide (profenofos 40% + cypermethrin 4% EC) is on the rise in India and elsewhere. Cypermethrin is reported to be a tumor promoter, but its tumor-promoting potential along with profenofos is yet to be studied. A short-term, in vivo test for detection of a tumor promoter is cost-effective, saves time, and requires fewer animals than conventional methods. We report on a short-term test based on mechanisms of significant importance in tumor promotion. In this study, we have tested the tumor-promoting potential of a combination pesticide containing profenofos 40% and cypermethrin 4% EC in Wistar rats. Although cypermethrin has been reported as a tumor promoter, our study shows that the combination pesticide containing profenofos 40% and cypermethrin 4% EC is not a tumor promoter.
Murali Mohan
E
E
Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology (FIPPAT), Padappai, Tamil Nadu, India.
Rajaran Gayathri
M
M
Amirtha Ganesh
D
D
Banu Priya
C A
CA
Arun Sam Lal
A
A
Amalan Stanley
V
V
Sadasivan Pillai
K
K
Balakrishnamurthy
P
P
D000818:Animals; D001681:Biological Assay / Q000379:methods; D003362:Cost-Benefit Analysis; D004347:Drug Interactions; D007306:Insecticides / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009369:Neoplasms / Q000139:chemically induced* / Q000662:veterinary; D063086:Organothiophosphates / Q000008:administration & dosage / Q000009:adverse effects*; D011722:Pyrethrins / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D007306:Insecticides; D063086:Organothiophosphates; D011722:Pyrethrins; C017160:cypermethrin; C024273:profenofos