title: The spliceosome: no assembly required?
abstract: In this issue of Molecular Cell, Stevens et al. purify a large particle from yeast extracts that contains all five of the U snRNPs required for pre-mRNA splicing. The existence of this "penta-snRNP" suggests the provocative possibility that spliceosome assembly does not depend upon a pre-mRNA substrate.
authors.affiliation: Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, 44106, Cleveland, OH, USA
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Nilsen
mesh_terms: D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing; D017411:Ribonucleoproteins, Small Nuclear / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D017381:Spliceosomes / Q000235:genetics* / Q000378:metabolism
chemical_list: D012322:RNA Precursors; D017411:Ribonucleoproteins, Small Nuclear