n-6 Polyunsaturated fatty acids increase skin but not cervical cancer in human papillomavirus 16 transgenic mice.
Using a mouse with transgenes for the highly oncogenic human papillomavirus type 16, we asked whether a diet high in fat, namely, the n-6 polyunsaturated fatty acid linoleic acid, would influence the development of skin or cervical cancer. Virgin female keratin 14-human papillomavirus 16 transgenic mice were fed control diet or diet with 20% corn oil. The effect of these diets was compared in mice implanted or not implanted with 0.125 mg/60 day release of estradiol. More precancers and cancers of the skin developed faster in mice fed the high-fat diet. Estrogen had no effect on the development of skin cancers. In contrast, estrogen was necessary for the development of cervical cancer, and a high-fat diet had no effect on the development of cervical cancer.
Qi
Mei
M
North Shore-Long Island Jewish Research Institute, Manhasset, New York 11030, USA.
Chen
DaZhi
D
Liu
Kai
K
Auborn
Karen J
KJ
D000818:Animals; D003043:Cocarcinogenesis; D003314:Corn Oil / Q000008:administration & dosage / Q000009:adverse effects*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D027383:Papillomaviridae / Q000235:genetics*; D012878:Skin Neoplasms / Q000209:etiology* / Q000821:virology; D019076:Transgenes; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000821:virology
D004042:Dietary Fats, Unsaturated; D003314:Corn Oil