title: Thalidomide therapy for recalcitrant systemic onset juvenile rheumatoid arthritis.
abstract: Systemic onset juvenile rheumatoid arthritis unresponsive to nonsteroidal anti-inflammatory drugs may be controlled with corticosteroids, but these drugs have significant side effects. We report 2 steroid-dependent children with systemic onset juvenile rheumatoid arthritis who did not respond to multiple nonsteroidal anti-inflammatory drugs, methotrexate, azathioprine, cyclosporine, and etanercept. Both children had significant improvement with thalidomide therapy.
authors.affiliation: Division of Pediatric Rheumatology, Hospital for Special Surgery, Department of Pediatrics, Sanford Weill Medical Center of Cornell University, New York 10021, USA.
authors.forename: Thomas J A
authors.initials: TJ
authors.lastname: Lehman
authors.forename: Kim H
authors.initials: KH
authors.lastname: Striegel
authors.forename: Karen B
authors.initials: KB
authors.lastname: Onel
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002648:Child; D006801:Humans; D008297:Male; D013792:Thalidomide / Q000627:therapeutic use*
chemical_list: D013792:Thalidomide