title: Identification of pharmaceutical glasses by laser ablation ICP-MS.
abstract: The chemical composition of pharmaceutical glasses (ampoules, infusion bottles, plunger) has been determined by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). A Nd:YAG laser with 10 Hz repetition rate in the Q-switch mode at its fundamental wavelength (1064 nm) was used to identify common types of pharmaceutical glasses. The following isotopes were used for measurements: 7Li, 11B, 23Na, 24Mg, 27Al, 28Si, 29Si, 30Si, 39K, 42Ca, 47Ti, 57Fe, 90Zr, 121Sb, 137Ba. Each analysis included the measurement of 12 craters. Relative standard deviations between 1.8% and 8.0% of the quantitative results were obtained. 29Si was used as internal standard. Standard reference materials (soda-lime-, lead- and borosilicate glasses) were used for external calibration of laser sampling. Linear calibration functions for each isotope were found. All samples and standard materials were digested in a two-step-procedure by nitric/fluoric acid, then measured and externally calibrated by ICP-MS with multi-elemental standard solutions using 45Sc as internal standard. Digestion and laser ablation results agree within 8% (confidential interval 95%) with the certified values. Intensity ratios of most isotopes also agree sufficiently with the corresponding theoretical values (+/- 18%). The developed method allows to distinguish different types of pharmaceutical glasses.
authors.affiliation: Institute of Pharmacy, Humboldt University, Berlin, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Schmidt
authors.forename: J P
authors.initials: JP
authors.lastname: Surmann
authors.forename: H
authors.initials: H
authors.lastname: Stephanowitz
authors.forename: E
authors.initials: E
authors.lastname: Hoffmann
mesh_terms: D002138:Calibration; D004349:Drug Packaging; D005898:Glass / Q000737:chemistry*; D007554:Isotopes; D007834:Lasers; D013058:Mass Spectrometry; D012015:Reference Standards; D015203:Reproducibility of Results; D013499:Surface Properties
chemical_list: D007554:Isotopes