Synthesis and anti-HIV activity of new modified 1,2,3-triazole acyclonucleosides.
The synthesis of 1,2,3-triazole acyclonucleosides 7a-h via 1,3-dipolar cycloaddition of N-9/N-1-propargylpurine/pyrimidine 2a-h with azido-pseudo-sugar 4 is described and none of them had anti-HIV activity.
Lazrek
H B
HB
Laboratoire de Chimie Bio-Organique, Faculté des Sciences Semlalia, Marrakech, Maroc.
Taourirte
M
M
Oulih
T
T
Barascut
J L
JL
Imbach
J L
JL
Pannecouque
C
C
Witrouw
M
M
De Clercq
E
E
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry*
D019380:Anti-HIV Agents; D009705:Nucleosides; D014230:Triazoles