An autosome-wide search for loci underlying wheezing age of onset in German asthmatic children identifies a new region of interest on 6q24-q25.
While numerous familial studies of asthma have identified several distinct chromosomal regions, no linkage studies have been performed taking into account the age of onset of disease. Here, we performed a genome-wide scan to search for loci linked either to asthma or wheezing age of onset in a population of German asthmatic children by incorporating survival analysis techniques in the maximum-likelihood-binomial approach. In addition to several regions already reported in asthma, wheezing age of onset was found to be strongly linked to chromosome 6q24-q25 (lod score = 3.56). Interestingly, this region contains some candidates genes such as the gene coding for the IFN-gamma receptor ligand-binding chain.
Alcaïs
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INSERM U436, Faculté Pitié-Salpêtrière, Laboratory of Human Genetics of Infectious Diseases, Faculté Necker, Paris, France.
Plancoulaine
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Abel
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D000293:Adolescent; D000367:Age Factors; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002896:Chromosomes, Human, Pair 6; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D005828:Genetics, Population; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007223:Infant; D016013:Likelihood Functions; D008297:Male; D012135:Respiratory Sounds / Q000235:genetics*; D016019:Survival Analysis
D005819:Genetic Markers