Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared.
Ulcerative colitis and colonic Crohn's disease (together known as inflammatory bowel disease or IBD) are both associated with increased risk for colorectal cancer. Although it is customary to emphasize differences in the biology of IBD-associated and sporadic colon cancer, we believe these are far outweighed by the similarities. These similarities suggest that they might have similar pathogenic mechanisms. Because the normal colon is arguably in a continual state of low-grade inflammation in response to its microbial flora, it is reasonable to speculate that both IBD-associated and sporadic colon cancer might be the consequence of bacteria-induced inflammation.
Rhodes
Jonathan M
JM
Dept of Medicine, University of Liverpool, Daulby Street, Liverpool, UK L69 3GA. rhodesjm@liverpool.ac.uk
Campbell
Barry J
BJ
D015179:Colorectal Neoplasms / Q000175:diagnosis*; D004249:DNA Damage; D006031:Glycosylation; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis*; D008954:Models, Biological