[The relationship between bone mineral density and polymorphism of the estrogen receptor gene in Chinese healthy menopausal women].
OBJECTIVE
To investigate the possible relationship between bone mineral density (BMD) and polymorphism of the estrogen receptor (ER) gene in Chinese healthy postmenopausal women.


METHODS
237 unrelated healthy postmenopausal women were selected for bone mineral density determination with Dual energy X-ray absorptiometry (DEXA) and the polymorphism of estrogen receptor gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
It is shown that the distribution of ER genotype in the ER gene was as follows: PP 19.8%, Pp 44.3% and pp 35.9% respectively. ANOVA analysis indicated that BMD of trochanter major (Troch) was associated with polymorphism of ER gene (P = 0.0106). Multiple stepwise regression analysis showed that the relationship between polymorphism of ER gene and BMD of Troch (P = 0.0548) and lumbar vertebra 2 approximately 4 (P = 0.0998) was not statistically significant.


CONCLUSIONS
It is suggested that there is a significant relationship between polymorphism of ER gene and Troch BMD in healthy postmenopausal women. p allele may be a protective factor for bone mass loss.
Wang
Q
Q
Department of Osteoporosis, The Sixth People's Hospital of Shanghai, Shanghai 200233, China.
Huang
Q
Q
Zhou
Q
Q
D000368:Aged; D015519:Bone Density; D005260:Female; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics*
D011960:Receptors, Estrogen