Structure-activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576.
As part of a programme to identify further analogues of the dual topo I/II inhibitor XR11576, we describe here the syntheses and SAR studies of various 'minimal' and 3,4-benzofused phenazine chromophores of the phenazine template of XR11576.
Wang
Shouming
S
Department of Medicinal Chemistry, Xenova Ltd., 957 Buckingham Avenue, Slough, Berkshire SL1 4NL, UK. shouming_wang@xenova.co.uk
Miller
Warren
W
Milton
John
J
Vicker
Nigel
N
Stewart
Alistair
A
Charlton
Peter
P
Mistry
Prakash
P
Hardick
David
D
Denny
William A
WA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D010619:Phenazines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured
C446952:4-methoxybenzo(a)phenazine-11-carboxylic acid (2-(dimethylamino)-1-methylethyl)amide; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D010619:Phenazines; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors