Structural genomics and signaling domains.
Many novel signal transduction domains are being identified in the wake of genome sequencing projects and improved sensitivity in homology-detection techniques. The functions of these domains are being discovered by hypothesis-driven experiments and structural genomics approaches. This article reviews the recent highlights of research on modular signaling domains, and the relative contributions and limitations of the various approaches being used.
Hurley
James H
JH
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0580, USA. jh8e@nih.gov
Anderson
D Eric
DE
Beach
Bridgette
B
Canagarajah
Bertram
B
Ho
Yew Seng Jonathan
YS
Jones
Eudora
E
Miller
Greg
G
Misra
Saurav
S
Pearson
Matt
M
Saidi
Layla
L
Suer
Silke
S
Trievel
Ray
R
Tsujishita
Yosuke
Y
D000818:Animals; D019295:Computational Biology; D023281:Genomics / Q000379:methods*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary / Q000502:physiology*; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
D011506:Proteins