[Linkage of familial combined hyperlipidemia to chromosome 1q21-23 in Chinese and German families].
OBJECTIVE
To examine familial combined hyperlipidemia (FCHL) families from nonisolated regions in China and Germany to see if we could corroborate support for a chromosome 1q FCHL locus in more general populations.


METHODS
We recruited 24 German families with 133 members and 12 Chinese families with a total of 81 members in China. The markers ApoA2, D1S1677, D1S104, and D1S194 were examined by multipoint linkage analysis.


RESULTS
Multipoint linkage analysis allowing for heterogeneity gave a maximum LOD score (HLOD) of 1.97 right over D1S194, estimating the proportion of linked families at 17%. This marker was adjacent to D1S104. The evidence for linkage was roughly the same both in the German (13%, HLOD(D1S194) = 1.08) and Chinese families (proportion of linked families 26%, HLOD(D1S194) = 0.97).


CONCLUSIONS
In the light of the relatively small numbers and the heterogeneity our populations represent, we interpret our observations as encouraging support for the recent findings indicating the presence of linkage for FCHL on chromosome 1q21-23.
Pei
W
W
Sino-German Laboratory for Molecular Medicine, Fu Wai Hospital, Cardiovascular Institute, PUMC & CAMS, Beijing 100037, China.
Baron
H
H
Müller-Myhsok
B
B
D016633:Apolipoprotein A-II / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005260:Female; D008040:Genetic Linkage; D005858:Germany / Q000208:ethnology; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000235:genetics*; D008297:Male; D044465:White People / Q000235:genetics*
D016633:Apolipoprotein A-II