title: An efficient and versatile synthesis of acylpolyamine spider toxins.
abstract: An efficient and versatile synthesis of acylpolyamine spider toxins was developed based on the structural classification of the Nephila and Nephilengys spider toxins using the 2-nitrobenzenesulfonamide protecting group. The naturally occurring toxins 1-5 representing each structural type have been efficiently synthesized by this method in a high overall yield with few steps.
authors.affiliation: Institute of Chemistry, University of São Paulo, São Paulo, SP 05508-900, Brazil.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nihei
authors.forename: Massuo J
authors.initials: MJ
authors.lastname: Kato
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yamane
authors.forename: Mario S
authors.initials: MS
authors.lastname: Palma
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Konno
mesh_terms: D000818:Animals; D015317:Biogenic Polyamines / Q000138:chemical synthesis*; D002853:Chromatography, Liquid; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry; D013111:Spider Venoms / Q000138:chemical synthesis*; D013112:Spiders; D013329:Structure-Activity Relationship
chemical_list: D015317:Biogenic Polyamines; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; C426070:JSTX-3; D011073:Polyamines; D013111:Spider Venoms