A BLAST from the past: ancient origin of human Sm proteins.
In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interactions between RNA molecules.
Donahue
William F
WF
Department of Pharmacology and Experimental Therapeutics, Boston University Medical Center, 80 East Concord Street, Boston, MA 02118, USA.
Jarrell
Kevin A
KA
D001324:Autoantigens / Q000235:genetics* / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D019143:Evolution, Molecular; D035001:Host Factor 1 Protein; D006801:Humans; D034982:Integration Host Factors; D011485:Protein Binding; D012313:RNA / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D017411:Ribonucleoproteins, Small Nuclear / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D055517:snRNP Core Proteins; D058727:RNA, Small Untranslated
D001324:Autoantigens; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D035001:Host Factor 1 Protein; D034982:Integration Host Factors; D012313:RNA; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; D017411:Ribonucleoproteins, Small Nuclear; D014157:Transcription Factors; D055517:snRNP Core Proteins; C440502:integration host factor, E coli; C499686:oxyS small RNA, E coli; D058727:RNA, Small Untranslated