Regulation of IL-5 expression.
Interleukin 5 (IL-5) is a cytokine primarily involved in the pathogenesis of atopic diseases. It specifically controls the production, activation and localization of eosinophils, the major cause of tissue damage in atopic diseases. IL-5 belongs to a gene family shared by IL-3, IL-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF) and is predominantly regulated at the transcriptional level. A variety of stimuli and modulators have been identified as regulating production of IL-5 both in vivo and in vitro, indicating a highly complex series of control mechanisms. However, a better understanding of the biology of IL-5 and the regulation of its expression is crucial for the development of new therapeutic agents for allergic disease. This review covers the major molecular aspects of IL-5 research.
Mordvinov
V A
VA
Curtin University of Technology, Perth, Western Australia. slava@cyllene.uwa.edu.au
Sanderson
C J
CJ
D000818:Animals; D004804:Eosinophils / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology; D066298:In Vitro Techniques; D015848:Interleukin-5 / Q000235:genetics*; D051379:Mice; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D015848:Interleukin-5