Interference with withdrawal signs of naloxone-induced opiate withdrawal under anesthesia is anesthetic-specific in opiate-dependent rats.
We hypothesized that interference of opiate antagonist-precipitated withdrawal signs under anesthesia is anesthetic-specific. Three groups of morphine-dependent rats were compared in different experimental conditions using a protocol of rapid withdrawal induction by an antagonist under anesthesia. We observed that ketamine and midazolam have different effects on the expression of withdrawal. This brings specific insights into the pharmacological basis of therapy with induction of opiate antagonist.
Streel
E
E
CHU Brugmann (Université Libre de Bruxelles), Institut de Psychiatrie, Clinique d'Alcoologie & Toxicomanies, Brussels, Belgium. manu.streel@chu-brugmann.be
Dan
B
B
Bredas
P
P
Clement
B
B
Pelc
I
I
Verbanck
P
P
D000768:Anesthesia, General / Q000009:adverse effects*; D000778:Anesthetics, Dissociative / Q000009:adverse effects; D000818:Animals; D003672:Defecation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007649:Ketamine / Q000009:adverse effects; D008297:Male; D008874:Midazolam / Q000009:adverse effects; D009021:Morphine Dependence / Q000188:drug therapy*; D009270:Naloxone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D014554:Urination / Q000187:drug effects
D000778:Anesthetics, Dissociative; D009292:Narcotic Antagonists; D009270:Naloxone; D007649:Ketamine; D008874:Midazolam