Immunological study of hereditary motor and sensory neuropathy type 1a (HMSN1a).
OBJECTIVE
Fifty three patients were studied to investigate whether autoimmune or inflammatory mechanisms could explain the phenotypic heterogeneity of patients with hereditary motor and sensory neuropathy type 1a (HMSN1a).


METHODS
Serum samples were examined for antibodies to peripheral nerve myelin protein 22 (PMP22), ganglioside GM1 and cauda equina homogenate, and interleukin-6 (IL-6) and soluble tumour necrosis factor receptor 1 (sTNF R1) concentrations. Serological results were compared with those from patients with other neuropathies (ONPs, n=30) and with normal subjects (n=51).


RESULTS
In the group as a whole, no relation emerged between clinical severity and any immune parameters. Immunohistochemical examination of four sural nerve biopsies did not show significant inflammatory infiltration. In a subset of 12 patients who experienced stepwise progression of disease, there was a trend towards a higher proportion having anti-PMP22 antibodies (33% v 15% of those with gradual disease progression, 3% ONPs, and no normal controls) and complement fixing antibodies to human cauda equina (25% v 5% with gradual progression, 8.6% ONPs, 3.9% normal controls, p=0.07).


CONCLUSIONS
Patients with HMSN1a and a stepwise disease progression may have an inflammatory, autoimmune component superimposed on the genetic condition.
Gabriel
C M
CM
Department of Neuroimmunology, Guy's King's and St Thomas' School of Medicine, Hodgkin Building, Guy's Hospital, London SE1 9RT, UK.
Gregson
N A
NA
Wood
N W
NW
Hughes
R A C
RA
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D002420:Cauda Equina / Q000276:immunology; D002607:Charcot-Marie-Tooth Disease / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D002886:Chromosomes, Human, Pair 17; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D020440:Gene Duplication; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D047888:Receptors, Tumor Necrosis Factor, Type I
D015703:Antigens, CD; D001323:Autoantibodies; D018836:Inflammation Mediators; D015850:Interleukin-6; D009185:Myelin Proteins; C073687:PMP22 protein, human; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D005677:G(M1) Ganglioside