Myocyte renewal and ventricular remodelling.
Remaining young at heart is a desirable but elusive goal. Unbeknown to us, however, myocyte regeneration may accomplish just that. Continuous cell renewal in the adult myocardium was thought to be impossible, but multipotent cardiac stem cells may be able to renew the myocardium and, under certain circumstances, can be coaxed to repair the broken heart after infarction.
Anversa
Piero
P
Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA. piero_anversa@nymc.edu
Nadal-Ginard
Bernardo
B
D000818:Animals; D002455:Cell Division; D016922:Cellular Senescence; D005544:Forecasting; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy; D009206:Myocardium / Q000166:cytology*; D012038:Regeneration; D020257:Ventricular Remodeling