title: [Long-term prospective study of hepatitis B virus carriers using clinical laboratory and morphological analyses].
abstract: OBJECTIVE
  Analysis of long-term outcomes of carriage of hepatitis B virus surface antigen (HBsAg).
  
  
  METHODS
  Complete clinical, device, serological and partial morphological examinations of patients with latent form of HBV infection were performed 16-22 years after the infection with HBV.
  
  
  RESULTS
  Progression to chronic viral hepatitis (morphologically--hepatitis B) with a trend to annular hepatic tissue rearrangement was stated in all the examinees. Despite the development of chronic hepatitis, serological profile and PCR indicated HBV elimination.
  
  
  CONCLUSIONS
  All patients with latent HBV infection need regular observation because in the absence of symptoms worsening of clinico-biochemical and morphological indices takes place. Therefore, these patients should receive specific antiviral therapy.
authors.forename: T V
authors.initials: TV
authors.lastname: Sologub
authors.forename: S V
authors.initials: SV
authors.lastname: Sokolov
authors.forename: A D
authors.initials: AD
authors.lastname: Skorina
authors.forename: M V
authors.initials: MV
authors.lastname: Borzanova
mesh_terms: D001706:Biopsy; D002353:Carrier State; D006509:Hepatitis B / Q000175:diagnosis* / Q000473:pathology; D006511:Hepatitis B Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D012698:Serologic Tests
chemical_list: D006511:Hepatitis B Antigens