[The value of combined use of bone marrow smear and section in lymphoma for diagnosis and staging].
OBJECTIVE
To explore the value of combined use of bone marrow smear and section in lymphoma for diagnosis and staging.


METHODS
Smears of peripheral blood and bone marrow from 114 cases of lymphoma were stained according to Wright. Plastic embedded sections of the 114 cases were stained according to HE, HGF and Gomori.


RESULTS
None of the 7 patients with Hodgkin's lymphoma (HD) presented bone marrow involvement, while 32 (29.9%) of the 107 patients with Non-Hodgkin's lymphoma (NHL) presented bone marrow involvement, 13 (40.6%) of the 32 cases in stage I, II, III were promoted to stage IV after bone marrow examination. In 5 of the 32 patients without lymphadenopathy the diagnosis of lymphoma was established through bone marrow study. Lymphoma cells in bone marrow and peripheral blood varied in morphology. Bone marrow involvement might be focal (81.3%) or diffused (18.7%). There were mainly five type: (1) Small lymphocyte type. (2) blast-like lymphocyte type. (3) multimorphology type. (4) lymphoplasmacytoid cell type. (5) granuloma type.


CONCLUSIONS
Bone marrow examination is of importance in patients with known or suspected lymphomas and it may be diagnostic in patients without lymphadenopathy or in cases with no conclusive histological evidence from other sites.
Cui
P
P
PLA General Hospital, Beijing 100853.
Lou
F
F
Fu
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination; D002648:Child; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging