title: Antimicrobial activity of prosthetic heart valve sewing cuffs coated with minocycline and rifampin.
abstract: Prosthetic heart valve sewing cuffs coated with minocycline and rifampin exhibited in vitro zones of inhibition against all 52 tested clinical isolates responsible for prosthetic valve endocarditis. An in vitro elution study of these coated sewing cuffs demonstrated residual zones of inhibition against Staphylococcus epidermidis for at least 4 weeks.
authors.affiliation: Center for Prostheses Infection, Baylor College of Medicine and Veterans Affairs Medical Center, St. Luke's Episcopal Hospital, Houston, Texas 77030, USA. rdarouiche@aol.com
authors.forename: Rabih O
authors.initials: RO
authors.lastname: Darouiche
authors.forename: Vance G
authors.initials: VG
authors.lastname: Fowler
authors.forename: Karim
authors.initials: K
authors.lastname: Adal
authors.forename: Marcia
authors.initials: M
authors.lastname: Kielhofner
authors.forename: David
authors.initials: D
authors.lastname: Mansouri
authors.forename: L Barth
authors.initials: LB
authors.lastname: Reller
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000494:pharmacology* / Q000627:therapeutic use; D001407:Bacillus / Q000187:drug effects; D004359:Drug Therapy, Combination; D006350:Heart Valve Prosthesis / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology* / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D012293:Rifampin / Q000494:pharmacology* / Q000627:therapeutic use; D013212:Staphylococcus epidermidis / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D008911:Minocycline; D012293:Rifampin