[Changes in synthesis of nitric oxide, blood levels of ACTH and cortisol in viral hepatitis B].
We examined 170 patients with acute viral hepatitis B (AVH-B) and 10 patients with chronic hepatitis B (CH-B) exacerbation. 85% of them were under 40 years old. During the 12-hour night period we measured urine excretion of nitrites (NO2-) and nitrates (NO3-). It was significantly high in AVH-B but in CH-B exacerbation it did not differ from the controls. ACTH and hydrocortisone blood levels were significantly high in AVH-B and in CH-B exacerbation. Though hydrocortisonemia and nitrituria/nitraturia during AVH-B were both high, the correlation between them was negative due to nitric oxide (NO) synthesis suppression by hydrocortisone. A negative correlation between nitrituria/nitraturia and ALAT, ASAT, bilirubin, alkaline phosphatase, gamma-glutamyl-transpeptidase is an indirect evidence for a protective role of NO against viral hepatitis B.
Vinogradov
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D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D000368:Aged; D005260:Female; D006509:Hepatitis B / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000096:biosynthesis*
D009569:Nitric Oxide; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone