title: Intratubular calcification in a post-renal transplanted patient with secondary hyperparathyroidism.
abstract: In this article, we present a case in which marked intratubular calcification occurred in the transplanted kidney. The patient received living renal transplantation without control of severe secondary hyperparathyroidism, and the tacrolimus hydrate was used as an immunosuppressive agent, the adverse effects of which can induce intratubular calcification. Biopsy of the renal allograft revealed many intratubular calcifications in the cortex region of the specimen, although the histological grade was borderline for the Banff classification. The pathogenic causes of intratubular calcification were difficult to distinguish from the adverse effects of tacrolimus and the uncontrolled hyperparathyroidism.
authors.affiliation: Internal Medicine II, Niigata University School of Medicine, Niigata-city, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iguchi
authors.forename: S
authors.initials: S
authors.lastname: Nishi
authors.forename: J
authors.initials: J
authors.lastname: Shinbo
authors.forename: N
authors.initials: N
authors.lastname: Iino
authors.forename: J J
authors.initials: JJ
authors.lastname: Kazama
authors.forename: H
authors.initials: H
authors.lastname: Shimada
authors.forename: M
authors.initials: M
authors.lastname: Ueno
authors.forename: K
authors.initials: K
authors.lastname: Saitou
authors.forename: T
authors.initials: T
authors.lastname: Tanigawa
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: F
authors.initials: F
authors.lastname: Gejyo
mesh_terms: D001706:Biopsy; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000473:pathology*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology*; D008875:Middle Aged; D009397:Nephrocalcinosis / Q000473:pathology*; D016559:Tacrolimus / Q000009:adverse effects
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus