Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials.
In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke clinical trials. Rapid imaging with magnetic resonance imaging, diffusion weighted imaging, perfusion imaging and angiography are being incorporated into phase II and phase III stroke trials to optimize patient selection based on positive imaging diagnosis of the ischemic pathophysiology specifically related to a drug's mechanism of action and as a direct biomarker of the effect of a treatment's effect on the brain.
Warach
Steven
S
Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders & Stroke, Bethesda, Maryland, USA. warachs@ninds.nih.gov