[Experimental studies of the protective effects of basic fibroblast growth factor and Radix Salviae Miltiorrhizae on brain injury in rats caused by repeated exposures to +Gz].
Objective. To investigate the preventive and theralseutive (therapeutic) effects of basic fibroblast growth factor (bFGF) and Radix Salviae Miltiorrhizae (RSM) on brain injury caused by repeated +Gz exposures. Method. bFGF and RSM were injected intraperitoneally into SD rats before and after repeated +Gz exposures. The contents of excitatory amino acids (EAAs), nitric oxide (NO) and the number of cell apoptosis in the brain were measured, and were compared to those of the control group and normal saline (NS) group. Result. The contents of EAAs, NO and the number of cell apoptosis were significantly higher in repeated +Gz exposures group than those in control group. The values were markedly lower in bFGF and RSM group than those in repeated +Gz exposures group and NS group. Conclusion. bFGF and RSM showed distinct preventive and therapeutic effect on the brain injury induced by repeated +Gz exposures.
Liu
H J
HJ
Clinical Aeromedical Center, General Hospital of Air Force, Beijing, China.
Cai
Q
Q
Ji
G Y
GY
Wang
Z
Z
Jiang
J D
JD
Zhu
M C
MC
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D001930:Brain Injuries / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018846:Excitatory Amino Acids / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D018471:Hypergravity / Q000009:adverse effects*; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D018846:Excitatory Amino Acids; D009569:Nitric Oxide; D005346:Fibroblast Growth Factors