Susceptibility to telithromycin in 1,011 Streptococcus pyogenes isolates from 10 central and Eastern European countries.
Among 1,011 recently isolated Streptococcus pyogenes isolates from 10 Central and Eastern European centers, the MICs at which 50% of isolates are inhibited (MIC(50)s) and the MIC(90)s were as follows: for telithromycin, 0.03 and 0.06 microg/ml, respectively; for erythromycin, azithromycin, and clarithromycin, 0.06 to 0.125 and 1 to 8 microg/ml, respectively; and for clindamycin, 0.125 and 0.125 microg/ml, respectively. Erythromycin resistance occurred in 12.3% of strains. Erm(A) [subclass erm(TR)] was most commonly encountered (60.5%), followed by mef(A) (23.4%) and erm(B) (14.5%). At <0.5 microg/ml, telithromycin was active against 98.5% of the strains tested.
Nagai
Kensuke
K
Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
Appelbaum
Peter C
PC
Davies
Todd A
TA
Kelly
Linda M
LM
Hoellman
Dianne B
DB
Andrasevic
Arjana Tambic
AT
Drukalska
Liga
L
Hryniewicz
Waleria
W
Jacobs
Michael R
MR
Kolman
Jana
J
Miciuleviciene
Jolanta
J
Pana
Marina
M
Setchanova
Lena
L
Thege
Marianne Konkoly
MK
Hupkova
Helena
H
Trupl
Jan
J
Urbaskova
Pavla
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology; D005061:Europe, Eastern; D005798:Genes, Bacterial; D006801:Humans; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D004917:Erythromycin; D017963:Azithromycin; C106791:telithromycin