title: Effects of a bioartificial liver support system on acetaminophen induced acute liver failure canines.
abstract: AIM:To evaluate the safety and efficacy of the bioartificial liver support system in canines with acute liver failure (ALF).METHODS:Nine canines with acute liver failure by acetaminophen-induced received TECA-I bioartificial liver support system (BALSS) from Hong Kong TECA LTD Co. Blood was perfused through a hollow fiber tube containing (1-2)X10(10) the porcine hepatocytes.In contrast, another 10 canines with acute liver failure by Acetaminophen received drugs. Each treatment lasted 6 hours.RESULTS:BALSS treatment resulted in beneficial effects for acetaminophen-induced ALF canines with survival and with the recovery of the liver functions and tissues, and plasma ammonia decreased from 135.9&mgr;mol/L plus minus 17.5&mgr;mol/L to 65.7&mgr;mol/L plus minus 22.0&mgr;mol/L, 32.5&mgr;mol/L plus minus 8.8&mgr;mol/L, GPT from 97.8U/L plus minus 8.7U/L to 64.8U/L plus minus 11.9U/L, 19.0U/L plus minus 6.3U/L, GOT from 103.0U/L plus minus 16.7U/L to 75.7U/L plus minus 19.6U/L, 26.5U/L plus minus 5.0U/L, and AKP from 158.3U/L plus minus 12.1U/L to 114.5U/L plus minus 19.8U/L, 43.8U/L plus minus 5.6U/L during and after the treatment. In contrast, 10 ALF canines in both the drug and control groups died 1 or 2 days after treatment.CONCLUSION: TECA-1 artificial liver support system is safe and efficacious for canines with acute liver failure.
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Xue
authors.forename: Shi-Feng
authors.initials: SF
authors.lastname: Zhao
authors.forename: Zuo-Yun
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Yue-Feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Xin-Jian
authors.initials: XJ
authors.lastname: Li
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Huang
authors.forename: Yun
authors.initials: Y
authors.lastname: Luo
authors.forename: Ying-Cai
authors.initials: YC
authors.lastname: Huang
authors.forename: Cheng-Gui
authors.initials: CG
authors.lastname: Liu