[Severe cutaneous Streptococcus pyogenes infections in the child: results of a multicenter survey].
To assess pediatric cases of severe cutaneous infections due to Streptococcus pyogenes. Since the beginning of 1980, the incidence of cellulitis and necrotizing fasciitis due to S. pyogenes has increased in adults. Serotyping of obtained isolates are in most cases M1, M3 or M5 protein.


METHODS
A retrospective (1990-2000) survey was carried out in pediatric hospital centers.


RESULTS
Three cases of necrotizing fasciitis and 15 of cellulitis were observed. In 30% of the cases, vancella lesions were associated; in the other cases, minor wounds were the site of the infection. Bacteriologic diagnosis was made by local samples in 14 cases; blood cultures were positive in four cases. In 11 cases, initial intravenous treatment consisted of third generation cephalosporin, in six cases of penicillin M or G and in one case of fusidic acid. In the second time, penicillin M was perfused in the majority of the cases. Mean duration of intravenous antibiotics perfusion was 15 days. There were no sequelae or death in this survey.


CONCLUSIONS
Despite this study had limited epidemiological characteristics, it confirms that these two infections are rare. The frequency is probably underestimated, due to the difficulty in performing a diagnosis. The major site of infection was the varicella lesion. These two infections are so similar that it is frequent to mistake one infection for the other. Nonsteroidal anti-inflammatory drugs and site of infections did not influence prognosis. The treatment of cellulitis is penicillinotherapy whereas in necrotizing fasciitis early major surgery is often correlated with the rate of survival.
Marie-Cardine
A
A
Service de réanimation pédiatrique, centre hospitalier universitaire de Saint-Etienne, avenue A.-Raimond, 42055 Saint-Etienne, France.
Mallet
E
E
Billiemaz
K
K
Boulesteix
J
J
Bourrillon
A
A
Dechamps
C
C
Duhamel
J F
JF
Garnier
J M
JM
Gaudelus
J
J
Gendrel
D
D
Jeannot
E
E
Küpfer
I
I
Labbé
A
A
Lagardère
B
B
Meunier
M
M
Olivier
C
C
Reinert
P
P
D002481:Cellulitis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D002511:Cephalosporins / Q000008:administration & dosage; D002644:Chickenpox / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D019115:Fasciitis, Necrotizing / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D005672:Fusidic Acid / Q000008:administration & dosage; D006306:Health Surveys; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010406:Penicillins / Q000008:administration & dosage; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D013297:Streptococcus pyogenes; D015163:Superinfection / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology
D002511:Cephalosporins; D010406:Penicillins; D005672:Fusidic Acid