title: Se-methylselenocysteine: a new compound for chemoprevention of breast cancer.
abstract: Selenium compounds have attracted renewed interest as chemopreventive agents for human cancer on the basis of the pioneering intervention study by Clark and co-workers. The rodent mammary gland has been used extensively as a model for examining the chemopreventive activities of inorganic and organic selenium compounds. This review summarizes the rationale and results for use of a new organic selenium compound, Se-methylselenocysteine, which exhibits greater efficacy as a chemopreventive agent than several previously used selenium compounds in experimental models of breast cancer and has potential for use in human populations.
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. dmedina@bcm.tmc.edu
authors.forename: D
authors.initials: D
authors.lastname: Medina
authors.forename: H
authors.initials: H
authors.lastname: Thompson
authors.forename: H
authors.initials: H
authors.lastname: Ganther
authors.forename: C
authors.initials: C
authors.lastname: Ip
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000517:prevention & control*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control*; D016566:Organoselenium Compounds / Q000627:therapeutic use*; D017279:Selenocysteine / Q000031:analogs & derivatives; D016896:Treatment Outcome
chemical_list: D016588:Anticarcinogenic Agents; D016566:Organoselenium Compounds; D017279:Selenocysteine; D003545:Cysteine; C002979:selenomethylselenocysteine