Feline nasal and paranasal sinus tumours: clinicopathological study, histomorphological description and diagnostic immunohistochemistry of 123 cases.
Histological examination was performed in 123 cats with primary nasal and paranasal sinus tumours; 117 had undergone surgical biopsy and six necropsy. Special stains and immunohistochemistry were performed on poorly differentiated cases. Ninety-two percent (113/123) of the tumours were malignant. There was an increased risk for old cats (mean age of 10.9 years), and a male predilection (59% males). Clinical signs and breeds varied with the histological type of tumour. Thirty-nine percent (48/123) of the cases presented with nasal discharge, 21% (26/123) with dyspnea, 20% (24/123) with facial swelling, and 15% (19/123) with epistaxis. Forty-three percent (53/123) of the tumours were of epithelial origin. Adenocarcinomas (18/53) and squamous cell carcinomas (17/53) were the most common epithelial tumours. Fifty percent (26/53) of the epithelial tumours originated from the pseudo-stratified respiratory epithelium of the nasal cavity, 28% (15/53) from the stratified squamous epithelium of the vestibule, 9% (5/53) from olfactory epithelium, 9% (5/53) from submucosal glands and 4% (2/53) from minor salivary glands. Malignant lymphoma (35/123) was the most common tumour. Seventy-one percent (25/35) of the malignant lymphomas were B-cell tumours and 29% (10/35) were T-cell tumours. Six cases of malignant lymphomas were proved to be epitheliotropic T-cell lymphomas. This is the first report of a primary nasal epitheliotropic T-cell lymphoma in cats.
Mukaratirwa
S
S
Department of Pathology, Faculty of Veterinary Medicine, Utrecht University. smukaratirwa@esanet.zw
van der Linde-Sipman
J S
JS
Gruys
E
E
D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D000818:Animals; D001947:Breeding; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D002371:Cat Diseases / Q000453:epidemiology* / Q000473:pathology*; D002415:Cats; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008223:Lymphoma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D008297:Male; D009669:Nose Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D011996:Records / Q000662:veterinary; D012737:Sex Factors; D015030:Zimbabwe / Q000453:epidemiology