title: Can Eph receptors stimulate the mind?
abstract: The Eph receptors are multitalented tyrosine kinases capable of performing many tasks. The receptors together with their ligands--the ephrins--are well known to play a critical role in the initial assembly of neuronal circuits in the embryo. However, the recently discovered function of these receptors in the adult brain is now receiving significant acclaim. Three new articles show that the Eph receptors continue to be important in modifying the strength of existing neuronal connections (synapses). They do so in close association with at least one family of ion channels, the NMDA receptors.
authors.affiliation: The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Keith K
authors.initials: KK
authors.lastname: Murai
authors.forename: Elena B
authors.initials: EB
authors.lastname: Pasquale
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D004553:Electric Conductivity; D008568:Memory / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D036123:Receptor, EphA5; D036224:Receptor, EphB4; D036081:Receptors, Eph Family; D013569:Synapses / Q000502:physiology*
chemical_list: D020794:Receptor Protein-Tyrosine Kinases; D036123:Receptor, EphA5; D036224:Receptor, EphB4; D036081:Receptors, Eph Family