title: Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model.
abstract: To evaluate the performance of an artificial liver, we created a recoverable hepatic failure rat model. This involves a 30-60 minute warm ischemia, via clamping, of one-third of the liver with a partial (two-thirds) hepatectomy. Variations on this method provide for the possibility of several modes of hepatic failure. Survival time of the rats was prolonged (35%) by applying our hybrid artificial liver. However, the extracorporeal circulation is a considerable burden to the rat. Therefore, we need to apply the hybrid artificial liver intermittently and repeatedly.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Graduate School of Engineering, Kyusyu University, Fukuoka, Japan. ijima@apex.chem-eng.kyushu-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ijima
authors.forename: A
authors.initials: A
authors.lastname: Noguchi
authors.forename: T
authors.initials: T
authors.lastname: Katsuno
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: K
authors.initials: K
authors.lastname: Nakazawa
authors.forename: K
authors.initials: K
authors.lastname: Funatsu
authors.forename: K
authors.initials: K
authors.lastname: Kawakami
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D019164:Liver, Artificial; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results