title: New lanostanoids from the mushroom Ganoderma lucidum.
abstract: From a lipophilic extract of the fruiting body of Ganoderma lucidum, three new lanostanoids, 8beta,9alpha-dihydroganoderic acid J (1), methyl 8beta,9alpha-dihydroganoderate J (2), and 20-hydroxylganoderic acid G (3), along with 12 known lanostanoids and two ergostane sterols were isolated. The structures of 1-3 were determined by interpretation of their spectroscopic data.
authors.affiliation: Pharmanex, Inc., 75 West Center Street, Provo, Utah 84601, USA.
authors.forename: Jiyuan
authors.initials: J
authors.lastname: Ma
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Hua
authors.forename: Decheng
authors.initials: D
authors.lastname: Zhang
authors.forename: Raymond
authors.initials: R
authors.lastname: Cooper
authors.forename: Michael N
authors.initials: MN
authors.lastname: Chang
authors.forename: Joseph Y
authors.initials: JY
authors.lastname: Chang
authors.forename: Hao H
authors.initials: HH
authors.lastname: Sun
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020128:Inhibitory Concentration 50; D007371:Interferon-gamma / Q000032:analysis / Q000097:blood; D007376:Interleukin-2 / Q000032:analysis / Q000097:blood; D015847:Interleukin-4 / Q000032:analysis / Q000097:blood; D007810:Lanosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D020940:Reishi / Q000737:chemistry* / Q000276:immunology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: C449846:20-hydroxylganoderic acid G; C449847:8,9-dihydroganoderate J; C449845:8,9-dihydroganoderic acid J; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D007810:Lanosterol; D015847:Interleukin-4; D007371:Interferon-gamma