Evaluation of corneal graft rejection in a mouse model.
Corneal graft rejection presents clinically and in experimental models as opacification and is considered to be the result of endothelial cell dysfunction or loss. However, recovery from opacification can occur suggesting either (a) that new endothelial cells can regenerate if the original cells were lost, or (b) that sufficient numbers of original cells can regain function if the opacification was due to temporary dysfunction. In this perspective, previous experimental studies of allograft rejection plus some new data are reviewed to support the latter mechanism.
Plsková
J
J
Department of Ophthalmology, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK.
Kuffová
L
L
Holán
V
V
Filipec
M
M
Forrester
J V
JV
D000818:Animals; D003318:Corneal Opacity / Q000209:etiology / Q000473:pathology; D016039:Corneal Transplantation / Q000009:adverse effects / Q000473:pathology; D004728:Endothelium, Corneal; D006084:Graft Rejection / Q000209:etiology* / Q000473:pathology; D006085:Graft Survival; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D016019:Survival Analysis; D013536:Suture Techniques / Q000009:adverse effects*; D013997:Time Factors; D014184:Transplantation, Homologous / Q000473:pathology