Synthesis of 2-alkyl-substituted-N6-methyladenine derivatives as potential adenosine receptor ligand.
2-(1-Hexynyl), 2-((E)-1-hexenyl) and 2-(n-hexyl)-N6-methyladenines were synthesized, starting from 2-amino-6-chloropurine using palladium-catalyzed coupling as a key step as potential adenosine receptor ligand.
Kim
H O
HO
Division of Chemistry and Molecular Engineering, Seoul National University, Korea. hokim9@snu.ac.kr
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D018047:Receptors, Purinergic P1 / Q000187:drug effects / Q000378:metabolism
D018047:Receptors, Purinergic P1; D000225:Adenine