Evidence for a new mechanism of action of diclofenac: activation of K+ channels.
Ortiz
M I
MI
Sección Externa de Farmacología, Centro de Investigación y de Estudios Avanzados del IPN, México, D.F., Mexico.
Castañeda-Hernández
G
G
Rosas
R
R
Vidal-Cantú
G C
GC
Granados-Soto
V
V
D015761:4-Aminopyridine / Q000494:pharmacology; D018528:ATP-Binding Cassette Transporters; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004008:Diclofenac / Q000494:pharmacology*; D005260:Female; D005557:Formaldehyde; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D054086:KATP Channels; D010147:Pain Measurement / Q000187:drug effects*; D015221:Potassium Channels / Q000819:agonists*; D024661:Potassium Channels, Inwardly Rectifying; D051381:Rats; D017208:Rats, Wistar
D018528:ATP-Binding Cassette Transporters; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007004:Hypoglycemic Agents; D054086:KATP Channels; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; C092520:uK-ATP-1 potassium channel; D004008:Diclofenac; D005557:Formaldehyde; D015761:4-Aminopyridine; D005905:Glyburide