In vivo effects of phenolic compounds on blood parameters of a marine fish (Dicentrarchus labrax).
Sea bass (Dicentrarchus labrax) were injected intraperitoneally once (single dose) or three times (fractionated dose) with phenol or OH-phenols (hydroquinone, resorcinol, and pyrocatechol). On the basis of the lethal doses, OH-phenols were more toxic than phenol, and pyrocatechol was the most powerful compound. Hematological, metabolic and antioxidant blood parameters were measured 3 days after the end of the treatment. Metabolic variations as specific effects on erythrocytes were revealed and differences between single and fractionated doses were observed. OH-phenols-treated fish showed disorders in the metabolic toxicity indicators as hypoglycemia, low blood urea nitrogen level (BUN) and decrease of alkaline phosphatase activity (ALP). In addition, quantitative structure-activity relationships were developed using the n-octanol:water partition coefficient (log K(ow)). Positive correlations were found with ALP, plasma glucose and hemoglobin.
Roche
H
H
University of Paris-Sud, Laboratory of Ecology and Zoology, CNRS UPRESA 8079, Bât. 442, F91405 Orsay, France. helene.roche@ibaic.u-psud.fr
Bogé
G
G
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001492:Bass / Q000097:blood*; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002396:Catechols / Q000633:toxicity; D004909:Erythrocyte Indices / Q000187:drug effects; D006454:Hemoglobins / Q000187:drug effects* / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D010636:Phenols / Q000633:toxicity*; D021281:Quantitative Structure-Activity Relationship; D011802:Quinidine / Q000031:analogs & derivatives* / Q000633:toxicity; D012118:Resorcinols / Q000633:toxicity; D015996:Survival Rate; D015262:Xenobiotics / Q000633:toxicity
D001786:Blood Glucose; D002396:Catechols; D006454:Hemoglobins; D010636:Phenols; D012118:Resorcinols; D015262:Xenobiotics; C014486:hydroquinidine; D000469:Alkaline Phosphatase; D011802:Quinidine; C034221:catechol; D006854:Hydrocortisone; C031389:resorcinol