Coincident choroid plexus carcinoma and adrenocortical carcinoma with elevated p53 expression: a case report of an 18-month-old boy with no family history of cancer.
We describe a young patient with no known family history of cancer who presented at 18 months with 2 advanced primary tumors, choroid plexus carcinoma and adrenal cortical carcinoma. Immunohistochemical studies demonstrated high levels of nuclear p53 protein expression in both tumors, as well as in the adjacent normal-appearing adrenal cortical cell nuclei of the adrenal gland. The immunohistologic distribution of elevated p53 expression suggests that this individual has a de novo germline mutation affecting p53 gene expression.
Wang
Lina
L
Department of Pathology, Los Angeles County-University of Southern California Medical Center, Los Angeles, CA 90033, USA. lwang61@hotmail.com
Cornford
Marcia E
ME
D000306:Adrenal Cortex Neoplasms / Q000378:metabolism* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000378:metabolism* / Q000473:pathology; D016545:Choroid Plexus Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53