title: The effect of changes in depression on health related quality of life (HRQoL) in HIV infection.
abstract: This study prospectively evaluated the effect of treatment of major depression on psychosocial functioning (health-related quality of life (HRQoL)). Previously, we reported on a trial of 75 HIV+ patients who were blindly randomized to receive treatment with drug or placebo (N=25 to each of paroxetine, imipramine, or placebo). Forty-one individuals completed the entire trial (placebo = 14, antidepressant = 27). In this study, we assessed HRQoL using the Quality of Life Enjoyment and Satisfaction Questionnaire (QLESQ) and the Social Adjustment Scale (SAS) at baseline and the end of the trial (12 weeks) using a random effects model to estimate treatment effects. HIV/AIDS patients with a major depressive disorder who completed the clinical trial demonstrated a reduction in depression with response to treatment and a significant improvement in HRQoL with the exception of work and financial functioning. Effective management of depression in HIV/AIDS patients is important, especially with the importance of adherence in current HIV/AIDS antiviral therapy. HRQoL improved in patients regardless of drug or response group and as a function of being in this trial suggesting that medications may not be required to affect HRQoL outcomes and that disease management aspects of care are important.
authors.affiliation: University of Washington Department of Psychiatry and Behavior Sciences, Madison Clinic at Harborview Medical Center, Seattle, WA, USA. aelliott@u.washington.edu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Elliott
authors.forename: Joan
authors.initials: J
authors.lastname: Russo
authors.forename: Peter P
authors.initials: PP
authors.lastname: Roy-Byrne
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000523:psychology; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D015704:CD4 Antigens / Q000276:immunology; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000276:immunology / Q000523:psychology*; D006679:HIV Seropositivity / Q000523:psychology*; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use*; D010549:Personal Satisfaction; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D012917:Social Adjustment; D011795:Surveys and Questionnaires
chemical_list: D000928:Antidepressive Agents; D015704:CD4 Antigens; D017374:Paroxetine