title: Dietary manipulations of body fat-reducing potential of conjugated linoleic acid in rats.
abstract: To study whether the body fat-reducing potential of conjugated linoleic acid (CLA) could be increased through dietary manipulations, the effects of the combination of CLA with different proteins, fats, and sesamin were examined in rats. Male rats were fed diets containing 1% CLA or linoleic acid (LA) in combination with different proteins (20% of casein or soybean protein), fats (7% perilla oil or soybean oil) and 0.2% sesamin (SES) for 3 or 4 weeks. When the dietary fat source was soybean oil, CLA, as compared with LA, significantly reduced weights of epididymal and perirenal adipose tissues, irrespective of the dietary protein sources. However, the highest reducing effect was shown when soybean protein was given as a protein source. SES stimulated the reduction of epididymal and perirenal adipose tissue weights in both protein diets. In contrast, CLA increased the weight of brown adipose tissue, and SES further increased it in combination with soybean oil but not with perilla oil. No effect of dietary manipulation was observed on serum leptin and TNF-alpha levels. Thus, the body fat-reducing potential of CLA can be increased by an appropriate combination with food factors that may stimulate fatty acid beta-oxidation.
authors.affiliation: Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Japan. suganomi@pu-kumamoto.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Sugano
authors.forename: A
authors.initials: A
authors.lastname: Akahoshi
authors.forename: K
authors.initials: K
authors.lastname: Koba
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Okumura
authors.forename: H
authors.initials: H
authors.lastname: Matsuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: K
authors.initials: K
authors.lastname: Murao
authors.forename: M
authors.initials: M
authors.lastname: Yamasaki
authors.forename: M
authors.initials: M
authors.lastname: Nonaka
authors.forename: K
authors.initials: K
authors.lastname: Yamada
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000187:drug effects; D002001:Adipose Tissue, Brown / Q000033:anatomy & histology / Q000187:drug effects; D000818:Animals; D004038:Diet, Reducing; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage; D004149:Dioxoles / Q000008:administration & dosage; D020738:Leptin / Q000097:blood; D017705:Lignans / Q000008:administration & dosage; D008041:Linoleic Acids / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D004042:Dietary Fats, Unsaturated; D004044:Dietary Proteins; D004149:Dioxoles; D020738:Leptin; D017705:Lignans; D008041:Linoleic Acids; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; C054125:sesamin