Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to acyclic aliphatic enones.
Cu-catalyzed enantioselective conjugate additions to acyclic aliphatic enones are reported. The resulting enolates may be functionalized intra- and intermolecularly, leading to the formation of an additional C-C bond. The utility of the present method is not limited to reactions involving Et2Zn; a variety of alkylzincs may be used. Moreover, many of the requisite substrates can be easily accessed through catalytic olefin cross metathesis.
Mizutani
Hirotake
H
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.
Degrado
Sylvia J
SJ
Hoveyda
Amir H
AH