Effect of functional magnetic particles on radiofrequency capacitive heating: an in vivo study.
Specific heating of magnetic particles in radiofrequency (RF) capacitive hyperthermia and its hyperthermic effect were investigated in an in vivo study. Magnetite cationic liposomes (MCLs) were injected into a rat tumor on the femur and 8 MHz-RF capacitive heating was applied to the rat under "mild heating" conditions. Although the input power of RF capacitive heating was low under the same power conditions, the MCLs-injected tumor was heated over 43 degrees C, whereas it was only heated to 41 degrees C in the case of the rats not injected with MCLs. A necrotic area in the tumor was observed in the heated rats. From the results of histological observation of the removed tissue, the necrotic area in the MCLs-injected tumor was wider than that in MCLs-free tumor. Complete tumor suppression was observed in 71% (5 / 7) of MCLs-injected rats, and the hyperthermic effect was greatly improved by the MCLs.
Shinkai
Masashige
M
Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
Ueda
Kousuke
K
Ohtsu
Shinji
S
Honda
Hiroyuki
H
Kohri
Kenjiro
K
Kobayashi
Takeshi
T
D000818:Animals; D005260:Female; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D006358:Hot Temperature; D006979:Hyperthermia, Induced; D015552:Injections, Intralesional; D008081:Liposomes; D008280:Magnetics / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D011846:Radio Waves; D051381:Rats; D011916:Rats, Inbred F344; D014407:Tumor Cells, Cultured
D008081:Liposomes