[Diagnostic usefulness of cystatin C measurement].
Cystatin C is a new endogenous marker of renal function whose serum concentration correlates better with glomerular filtration rate than creatinine. Cystatin C has been suggested to be a marker of renal function). Cystatin C is a cysteine proteinase inhibitor. It is produced at a constant rate in all investigated nucleated cells, its gene is a housekeeping type. Cystatin C is freely filtered in the renal glomeruli and reabsorbed and catabolised in the proximal tubules. Reference intervals have been determined for cystatin C in adults and in children older than one year without gender differences. Several studies including adults and children with different renal diseases with various kidney function have suggested serum cystatin C to be a better marker of GFR than serum creatinine. Fully automated assays using particle-enhanced turbidimetry (PETIA) or particle-enhanced nephelometry (PENIA) are available and the assays are precise, rapid and usable in clinical routine practice.
Kozłowska
K
K
Zakład Laboratoryjnej Diagnostyki Pediatrycznej Akademii Medycznej w Białymstoku.
Wysocka
J
J
Janicka
K
K
D055316:Cystatin C; D015891:Cystatins / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000378:metabolism; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000378:metabolism*; D007677:Kidney Function Tests; D009391:Nephelometry and Turbidimetry / Q000295:instrumentation
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003546:Cysteine Endopeptidases