title: [BRCA1 gene mutations in early-onset breast cancer].
abstract: OBJECTIVE
  To detect BRCA1 gene mutations in early-onset breast cancer.
  
  
  METHODS
  We use polymerase chain reaction and single strand conformation polymorphism analysis (PCR-SSCP) to examine the mutation at BRCA1 gene exon 2, 11 and 20 in 10 patients with early-onset breast cancer.
  
  
  RESULTS
  Mutation was found in one cases (24 years old at diagnosis) at nucleotide 3 732, the substitution of a "G" to a "C" in codon 1 205 changed a Gly to a Arg.
  
  
  CONCLUSIONS
  Our data suggest that BRCA1 may have effect on early-onset breast cancer.
authors.affiliation: Peking Union Medical College Hospital, Beijing 100730, China.
authors.forename: X
authors.initials: X
authors.lastname: Ding
authors.forename: J
authors.initials: J
authors.lastname: Lang
mesh_terms: D000328:Adult; D017668:Age of Onset; D019943:Amino Acid Substitution; D019313:BRCA1 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D018807:Polymorphism, Single-Stranded Conformational; D017422:Sequence Analysis, DNA
chemical_list: D019313:BRCA1 Protein