title: Cooling decreases fos-immunoreactivity in the rat after formalin injection.
abstract: The effects of cooling on inflammatory response after injection of formalin in rats were examined by counting Fos-labeled cells in the dorsal horn of the spinal cord and evaluating swelling. A small amount of dilute formalin was injected into the right hindpaw of rats. The rats were divided into Cooling (-) and Cooling (+) groups and Fos-labeled cells in the spinal cord and paw volumes were compared between the two groups. In the Cooling (+) group, Fos-labeled cells were reduced significantly and the peak time of expression was delayed compared with the Cooling (-) group. Paw volumes were significantly smaller in the Cooling (+) group than in the Cooling (-) group. These results suggest that cooling therapy is effective by delaying the progress of inflammatory reactions and provides extra time for administration of analgesics or implementation of other clinical treatments.
authors.affiliation: Department of Orthopedic Surgery, Fukushima Medical University, Fukushima-shi, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kenjo
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Konno
mesh_terms: D000818:Animals; D017679:Cryotherapy / Q000379:methods*; D046508:Culture Techniques; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000276:immunology* / Q000628:therapy*; D005260:Female; D005557:Formaldehyde; D016762:Genes, fos / Q000276:immunology*; D007150:Immunohistochemistry; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology* / Q000628:therapy*; D010784:Photomicrography; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013116:Spinal Cord / Q000166:cytology
chemical_list: D005557:Formaldehyde