Toll-like receptors: key mediators of microbe detection.
Toll-like receptors are pattern-recognition receptors that have key roles in detecting microbes and initiating inflammatory responses. Recently, a host of new microbial products that activate specific Toll-like receptors have been defined, and additional components that mediate intracellular signaling have been identified. There has also been greater recognition of the importance of specific Toll-like receptors in host defense.
Underhill
David M
DM
Institute for Systems Biology, 4225 Roosevelt Way NE, Seattle, WA 98105, USA. dunderhill@systemsbiology.org
Ozinsky
Adrian
A
D000818:Animals; D029721:Drosophila Proteins; D006801:Humans; D007113:Immunity, Innate; D008024:Ligands; D008562:Membrane Glycoproteins / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors