Transmission/disequilibrium test analysis of total serum IgE levels in the Hutterite and Collaborative Study on the Genetics of Asthma data sets.
The Hutterite and Collaborative Study on the Genetics of Asthma data sets provided by Genetic Analysis Workshop 12 were analyzed using a regression-based transmission/disequilibrium test that assesses linkage between a marker locus and quantitative trait locus when allelic association is present, as proposed by George et al. [Am J Hum Genet 65:236-45, 1999]. Because the same marker set and analytical technique was used, the results from these data sets are amenable for comparison. Statistically significant results common to both data sets were found on chromosomes 1 and 3. A noteworthy result, significant at p < 10(-4), was detected on chromosome 18 in the Hutterites.
Jedrey
C M
CM
Dept. of Epidemiology and Biostatistics, Case Western Reserve University, MetroHealth Medical Center, R-258, 2500 MetroHealth Dr., Cleveland, OH 44109, USA.
Chen
C H
CH
Moser
K L
KL
Wedig
G C
GC
George
V
V
Tiwari
H K
HK
D000328:Adult; D000483:Alleles; D001249:Asthma / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002887:Chromosomes, Human, Pair 18; D003241:Consanguinity; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D015810:Linkage Disequilibrium; D008297:Male; D013023:South Dakota; D014481:United States
D005819:Genetic Markers; D007073:Immunoglobulin E