title: [Alkaline phosphatase].
abstract: High levels of alkaline phosphatase activity are characteristic of bone disease with increased osteoblastic activity, hepatobiliary disease with partial or complete biliary obstruction and transient hyperphosphatasemia in children. A gamma-glutamyl transpeptidase is often useful to differentiate whether an elevated alkaline phosphatase originates in the bones or the liver. A normal gamma-glutamyl transpeptidase suggests bone origin. A serum alkaline phosphatase isozyme pattern by electrophoresis is also necessary to differentiate various pathological states.
authors.affiliation: Department of Clinical Laboratory, Nagoya Ekisaikai Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Fukatsu
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001847:Bone Diseases / Q000175:diagnosis; D004796:Clinical Enzyme Tests / Q000379:methods; D019411:Clinical Laboratory Techniques; D003937:Diagnosis, Differential; D004586:Electrophoresis; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008107:Liver Diseases / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D000469:Alkaline Phosphatase