title: Marker selection by Akaike information criterion and Bayesian information criterion.
abstract: We carried out a discriminant analysis with identity by descent (IBD) at each marker as inputs, and the sib pair type (affected-affected versus affected-unaffected) as the output. Using simple logistic regression for this discriminant analysis, we illustrate the importance of comparing models with different number of parameters. Such model comparisons are best carried out using either the Akaike information criterion (AIC) or the Bayesian information criterion (BIC). When AIC (or BIC) stepwise variable selection was applied to the German Asthma data set, a group of markers were selected which provide the best fit to the data (assuming an additive effect). Interestingly, these 25-26 markers were not identical to those with the highest (in magnitude) single-locus lod scores.
authors.affiliation: Laboratory of Statistical Genetics, Rockefeller University, Box 192, 1230 York Avenue, New York, NY 10021, USA.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: D R
authors.initials: DR
authors.lastname: Nyholt
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D001499:Bayes Theorem; D002648:Child; D016002:Discriminant Analysis; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree
chemical_list: D005819:Genetic Markers