Novel translocation (9;12)(q22;q24) in secondary chondrosarcoma arising from hereditary multiple exostosis.
We report a new translocation in a patient with a history of hereditary multiple exostosis (HME) who developed a recurrent grade I chondrosarcoma involving the sacrum and retroperitoneum. Karyotypic analysis of the tumor revealed a sole chromosome abnormality t(9;12)(q22;q24.3). To our knowledge, this translocation has not been previously identified in either chondrosarcoma, HME, or related tumor types. Our novel translocation may be related to the sarcomatous degeneration of the pre-existing exostosis.
Lee
Francis Young-In
FY
Department of Orthopaedic Surgery, College of Physicians and Surgeons of Columbia University, 622 W. 168th St., PH 11, New York, NY, USA. fl127@columbia.edu
Zawadsky
Mark
M
Parisien
May
M
Ho
Mike
M
Murty
Vundavalli V V S
VV
Jayaraman
Thottala
T
Dick
Harold M
HM
D000328:Adult; D000367:Age Factors; D001859:Bone Neoplasms / Q000150:complications / Q000235:genetics*; D002813:Chondrosarcoma / Q000150:complications / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005097:Exostoses, Multiple Hereditary / Q000150:complications / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D012447:Sacrum / Q000473:pathology*; D014178:Translocation, Genetic / Q000235:genetics*