title: Hypersensitivity to glucocorticoids in patients with raised ICP : report of two cases.
abstract: Corticosteroids are widely used in patients with raised intracranial pressure associated with cerebral neoplasms, cerebral vascular malformations, cerebral ischaemia and benign intracranial hypertension. In general clinical practice, anti-allergic, anti-inflammatory and immuno-suppressive properties of corticosteroids are commonly utilised in the management of allergic and immunological diseases. However in exceptionally rare circumstances, steroids may be the cause of hypersensitive reactions. Authors report two patients with raised intracranial pressure who developed steroid hypersensitivity. A review of the relevant literature is discussed.
authors.affiliation: The National Neurosurgery Centre, Khoula Hospital, Post Box - 90, Postal Code - 116, Mina-Al-Fahal, Sultanate of Oman. rrsharma@omantel.net.om
authors.forename: R R
authors.initials: RR
authors.lastname: Sharma
authors.forename: S J
authors.initials: SJ
authors.lastname: Pawar
authors.forename: E J
authors.initials: EJ
authors.lastname: Dev
authors.forename: S
authors.initials: S
authors.lastname: Ebenezer
authors.forename: A K
authors.initials: AK
authors.lastname: Mahapatra
mesh_terms: D000328:Adult; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D019586:Intracranial Hypertension / Q000188:drug therapy*
chemical_list: D005938:Glucocorticoids