title: Temporal changes of cFos-like protein expression in medial vestibular nuclei following arsanilate-induced unilateral labyrinthectomy in rats.
abstract: The compensation of spontaneous nystagmus and head deviation following chemical unilateral labyrinthectomy (UL) induced by arsanilate was delayed compared with surgical UL. Surgical UL produced two phases of significant asymmetry of cFos-like (cFL) protein expression between the bilateral medial vestibular nuclei, with more expression in the contralateral medial vestibular nuclei to the injured side than in the ipsilateral medial vestibular nuclei 2 h after UL; the pattern reversed after 6 h and expression disappeared after 72 h. Chemical UL produced three phases of asymmetric expression, with more cFL protein expression in the contralateral medial vestibular nuclei than in the ipsilateral medial vestibular nuclei 6 h after UL and a reversed pattern after 12 h. Asymmetric expression 72 h after UL followed increased expression in the contralateral medial vestibular nuclei. These results suggest that the course of vestibular compensation and the temporal expression of cFL protein in the medial vestibular nuclei following UL differed between surgical and chemical labyrinthectomy.
authors.affiliation: Department of Physiology, Wonkwang University School of Medicine and Institute of Wonkwang Medical Science, Iksan 570-749, South Korea.
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Jae Hyo
authors.initials: JH
authors.lastname: Kim
authors.forename: Yuan-Zhe
authors.initials: YZ
authors.lastname: Jin
authors.forename: Davy
authors.initials: D
authors.lastname: Kry
authors.forename: Byung Rim
authors.initials: BR
authors.lastname: Park
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001147:Arsanilic Acid; D007758:Ear, Inner / Q000187:drug effects / Q000293:injuries / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D019416:Head Movements / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009759:Nystagmus, Pathologic / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D013506:Otologic Surgical Procedures; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D015837:Vestibular Diseases / Q000473:pathology / Q000503:physiopathology*; D014726:Vestibular Nuclei / Q000166:cytology / Q000378:metabolism*
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D001147:Arsanilic Acid