title: Topical treatment of sclerodermoid chronic graft vs. host disease.
abstract: Sclerodermoid chronic graft vs. host disease is a severe adverse immunologic reaction following allogeneic bone marrow transplantation, with deposition of collagen in the skin and possibly other soft tissues, resulting in loss of range of motion and functional capabilities. We present a case of a 14-yr-old girl who received a matched, unrelated donor bone marrow transplant for myelodysplastic syndrome complicated by sclerodermoid chronic graft vs. host disease, causing severe contractures of the shoulders, elbows, wrists, fingers, hips and knees. This case report and review of the literature regarding chronic graft vs. host disease suggest that a controlled trial of a multimodality therapeutic approach, including topical treatment, is warranted to determine whether this approach improves function in these patients.
authors.affiliation: Department of Rehabilitation Medicine, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA.
authors.forename: Donald M
authors.initials: DM
authors.lastname: Currie
authors.forename: Gudbjorg Kristin
authors.initials: GK
authors.lastname: Ludvigsdottir
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Diaz
authors.forename: Naynesh
authors.initials: N
authors.lastname: Kamani
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D003286:Contracture / Q000209:etiology / Q000534:rehabilitation*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology / Q000534:rehabilitation*; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000601:surgery; D010232:Paraffin / Q000494:pharmacology*; D016059:Range of Motion, Articular / Q000502:physiology; D012594:Scleroderma, Localized / Q000209:etiology / Q000534:rehabilitation*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D010232:Paraffin