Regulatory context is a crucial part of gene function.
Information about the time and place of gene transcription, which until recently was only possible by extensive experimental analysis, can now be predicted through in silico analysis. Using the human RANTES/CCL5 promoter, we show that organizational features of promoters derived from promoter sequences contain information about the spatial and temporal 'functional context' of expression.
Fessele
Sabine
S
Medizinische Poliklinik der Ludwig-Maximilians-Universität München, Schillerstr. 42, D-80336, Munich, Germany.
Maier
Holger
H
Zischek
Christian
C
Nelson
Peter J
PJ
Werner
Thomas
T
D000818:Animals; D018946:Chemokine CCL5 / Q000235:genetics*; D054360:Chemokine CXCL1; D054426:Chemokine CXCL2; D018925:Chemokines / Q000235:genetics; D019743:Chemokines, CXC; D002630:Chemotactic Factors / Q000235:genetics; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D005786:Gene Expression Regulation; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
C475829:CXCL1 protein, human; D018946:Chemokine CCL5; D054360:Chemokine CXCL1; D054426:Chemokine CXCL2; D018925:Chemokines; D019743:Chemokines, CXC; D002630:Chemotactic Factors; C475895:Cxcl1 protein, mouse; C404915:Cxcl2 protein, mouse; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins