Intermittent low dose itraconazole treatment for onychomycosis--long term follow-up.
Eighty-seven patients with toenail onychomycosis were treated with intermittent low-dose itraconazole, 200 mg day(-1) for one week every four weeks; this regimen was repeated six times. A total of 77 patients (88.5%) showed microscopical and cultural cure after 6 months of treatment. A three-year follow-up showed a relapse rate of 6.5% occurring only during the first year after treatment.
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Department of Dermatology, Hadassah University Hospital, Faculty of Medicine, Hebrew University, Jerusalem, Israel. fjonas@hadassah.org.il
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy*
D000935:Antifungal Agents; D017964:Itraconazole