Delayed reactivation of haloperidol induced photosensitive dermatitis by methotrexate.
A man whose psoriasis was well controlled on methotrexate treatment developed pellagra-like photosensitive dermatitis when he started taking haloperidol. Reactivation of his dermatitis was observed with methotrexate as a recall photosensitivity phenomenon. This false photosensitivity reaction of methotrexate is an important but rarely encountered adverse effect. A possible interaction between methotrexate and haloperidol is emphasised.
Thami
G P
GP
Department of Dermatology and Venereology, Government Medical College and Hospital, Sector 32 B, Chandigarh 160047, India.
Kaur
S
S
Kanwar
A J
AJ
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D017454:Dermatitis, Photoallergic / Q000209:etiology*; D004357:Drug Synergism; D006220:Haloperidol / Q000009:adverse effects*; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy
D014150:Antipsychotic Agents; D007166:Immunosuppressive Agents; D006220:Haloperidol; D008727:Methotrexate