Identification of high risk breast-cancer patients by gene expression profiling.
We previously used DNA array analyses in the molecular profiling of breast cancers. By cluster analysis of 55 patients, we identified a subpopulation of breast cancers-designated class A-that contained a high number of nodal-positive tumours and that had frequently developed distant metastases at the time of diagnosis. We have now analysed follow-up data from these patients. We found that, despite a median of only 23.5 months of follow-up, 11 of 22 patients in class A progressed to metastatic disease, and three of five patients classified as having a nodal status of N0 in this subpopulation developed distant metastases. Our analysis identifies breast-cancer patients with a high risk of disease recurrence, and could act as a first step towards improved patient-adapted therapy.
Ahr
André
A
Karn
Thomas
T
Solbach
Christine
C
Seiter
Tanja
T
Strebhardt
Klaus
K
Holtrich
Uwe
U
Kaufmann
Manfred
M
D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000145:classification / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D016000:Cluster Analysis; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D020869:Gene Expression Profiling / Q000379:methods* / Q000592:standards; D005820:Genetic Testing / Q000379:methods* / Q000592:standards; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000145:classification / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D009367:Neoplasm Staging; D020411:Oligonucleotide Array Sequence Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis
D014408:Biomarkers, Tumor