Signaling complexes: junctions on the intracellular information super highway.
An enigmatic yet fundamental principle of signal transduction is that parallel signaling pathways assembled from a common repertoire of enzymes are able to propagate diverse physiological responses. A key feature of such a mechanism is that separate signaling pathways are organized into localized transduction units, each tailored to respond optimally to a particular signal. Protein-protein interactions maintained by anchoring, adapter and scaffolding proteins provide the molecular glue that holds these signal transduction units together. A major objective of the signaling community is to ascertain how signals flow through compartmentalized transduction units that contain transmembrane receptors, protein kinases, phosphatases and their substrates.
Smith
F Donelson
FD
Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97201-3098, USA.
Scott
John D
JD
D000818:Animals; D019390:Arrestins / Q000502:physiology; D002451:Cell Compartmentation; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000502:physiology; D020935:MAP Kinase Signaling System; D046911:Macromolecular Substances; D008954:Models, Biological; D015398:Signal Transduction; D015003:Yeasts / Q000201:enzymology; D000071557:beta-Arrestins
D019390:Arrestins; D046911:Macromolecular Substances; D000071557:beta-Arrestins; D017868:Cyclic AMP-Dependent Protein Kinases; D020962:Heterotrimeric GTP-Binding Proteins