[A study of the hereditary susceptibility of HLA-DQA1 to essential hypertension, athrothrombotic brain infarction and lacunar stroke].
OBJECTIVE
To study the types of HLA-DQA1 alleles in patients with essential hypertension (EH), athrothrombotic brain infarction (ABI) and lacunar stroke (LS) and normal control individuals and the hereditary susceptibility of HLA-DQA1 alleles to those diseases.


METHODS
The allelic typing of HLA-DQA1 was detected by PCR-SSP in 155 cases of EH, ABI and LS and 64 normal individuals.


RESULTS
The frequencies of HLA-DQA1 * 0301 in EH, ABI and LS groups were obviously higher than that in normal control group (33.6538 vs. 17.9688, 36.5884 vs. 17.9688, 33.0645 vs. 17.9688, P < 0.01). The frequencies of HLA-DQA1 * 0103 in groups of EH, ABI, LS, ABI with EH, and LS with EH were lower than that in the normal control group (6.7308 vs17.1875, RR = 0.3916, P < 0.01; 6.0976 vs. 17.1875, RR = 0.3548, P < 0.05; 6.4566 vs17.1875, RR = 0.3754, P < 0.01; 2.3809 vs17.1875, RR = 0.1385, P < 0.01; 3.5714 vs. 17.1875, RR = 0.2078, P < 0.01.


CONCLUSIONS
HLA-DQA1 * 0301 allele may be a correlative gene with hereditary susceptibility of EH, ABI and LS, and HLA-DQA1 * 0103 allele may be a protective gene of those diseases.
Shen
N
N
Department of Western Internal Medicine, Huguosii Hospital of Traditional Chinese Medicine Affiliated to Beijing University of Traditional Chinese Medicine and Pharmacy, Beijing 100035, China.
Yan
Z
Z
He
P
P
D000328:Adult; D000368:Aged; D000483:Alleles; D002544:Cerebral Infarction / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000235:genetics*
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen