Translocation (15;17) and trisomy 21 in the microgranular variant of acute promyelocytic leukemia.
Cytogenetic abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as inv(16), t(8;21), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation t(15;17) characterizes acute promyelocytic leukemia (APL) (French-American-British [FAB] class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately one-third of patients with newly diagnosed APL. We present a 26-year-old Hispanic man diagnosed with the microgranular variant of APL (FAB class M3v) whose initial cytogenetics included t(15;17) and trisomy 21. The prognostic implications of trisomy 21 and other secondary cytogenetic aberrations in APL are reviewed. To our knowledge, this is the first reported case of trisomy 21 with t(15;17) in the microgranular variant of APL.
Spell
Derrick W
DW
Division of Hematology/Oncology, Department of Internal Medicine, UTMB, 301 University Boulevard, Route 0565, Galveston, TX 77555, USA. dwspell@utmb.edu
Velagaleti
Gopalrao V N
GV
Jones
Dennie V
DV
Velasquez
William S
WS
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D004314:Down Syndrome / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D011379:Prognosis; D014178:Translocation, Genetic / Q000235:genetics*