Differential expression of matrix metalloproteinases and the tissue inhibitor in human milk.
There are differences in the temporal expression of MMP-2 and TIMP-4 in human milk from Day 1 to 30 postpartum in healthy mothers of term pregnancies: (i) MMP-2 activity peaked at Day 1 (colostrum) then exponentially decreased afterwards; and (ii) The expression of TIMP-4 was maximal at Day 7 and persisted thereafter. From our preliminary findings, the differential expression of MMP and the tissue inhibitor in human milk may be related to the protective action of human milk.
Cheung
P Y
PY
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Sawicki
G
G
Gross
S
S
Van Aerde
J
J
Radomski
M
M
D000328:Adult; D015153:Blotting, Western; D010450:Endopeptidases / Q000494:pharmacology; D020345:Enterocolitis, Necrotizing / Q000517:prevention & control; D005260:Female; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D008895:Milk, Human / Q000378:metabolism*; D011247:Pregnancy; D019714:Tissue Inhibitor of Metalloproteinases / Q000096:biosynthesis*; D000097792:Tissue Inhibitor of Metalloproteinase-4
D010450:Endopeptidases; D020778:Matrix Metalloproteinase 2; D019714:Tissue Inhibitor of Metalloproteinases; D000097792:Tissue Inhibitor of Metalloproteinase-4