title: Effects of tributyltin on the MFO system of the clam Ruditapes decussata: a laboratory and field approach.
abstract: The in vivo interaction of tributyltin (TBT) with the microsomal monooxygenase (MFO) system of the clam Ruditapes decussata was studied. For this purpose, two experiments were designed: (1) a laboratory exposure to increasing nominal doses of TBT (90, 454 and 2268 ng l(-1)) for 1 week and (2) a clam transplant from a clean area to an organotin polluted marina for periods of up to 5 weeks. Chemical analysis of organotins in clam tissue was used to relate TBT body burden to the MFO response. Neither the laboratory nor the field transplant experiment showed any significant TBT effect on the clam's digestive gland MFO components (cytochrome P450 and cytochrome b(5)). However, a significant elevation in the NADPH cytochrome (P450) reductases at the low and medium TBT doses in the laboratory and a significant decrease in NADH cytochrome (b(5)) reductases, 1 week after the field transplant, was observed with further recovery to control levels thereafter.
authors.affiliation: Environmental Chemistry Department, IIQAB-CSIC, Jordi Girona, 18-26, 08034, Barcelona, Spain. msrqam@cid.csic.es
authors.forename: M
authors.initials: M
authors.lastname: Solé
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism; D004064:Digestive System / Q000201:enzymology; D005260:Female; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D011084:Polycyclic Aromatic Hydrocarbons / Q000378:metabolism; D014220:Trialkyltin Compounds / Q000633:toxicity*
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D014220:Trialkyltin Compounds; C011559:tributyltin; D015786:Cytochromes b5; D006899:Mixed Function Oxygenases; D009251:NADPH-Ferrihemoprotein Reductase