title: Solid-phase synthesis of alpha-substituted 3-bisarylthio N-hydroxy propionamides as specific MMP inhibitors.
abstract: A novel series of potent and specific MMP-2,3,9,13 inhibitors has been obtained by modulation on solid phase by alpha and aryl substitutions on 3-arylthio-N-hydroxy-propionamides starting from itaconic acid.
authors.affiliation: Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy sur Seine, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Chollet
authors.forename: Thierry
authors.initials: T
authors.lastname: Le Diguarher
authors.forename: Nathalie
authors.initials: N
authors.lastname: Kucharczyk
authors.forename: Armelle
authors.initials: A
authors.lastname: Loynel
authors.forename: Marc
authors.initials: M
authors.lastname: Bertrand
authors.forename: Gordon
authors.initials: G
authors.lastname: Tucker
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guilbaud
authors.forename: Mike
authors.initials: M
authors.lastname: Burbridge
authors.forename: Philippe
authors.initials: P
authors.lastname: Pastoureau
authors.forename: Armel
authors.initials: A
authors.lastname: Fradin
authors.forename: Massimo
authors.initials: M
authors.lastname: Sabatini
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Fauchère
authors.forename: Patrick
authors.initials: P
authors.lastname: Casara
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002358:Cartilage, Articular / Q000187:drug effects / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D061965:Matrix Metalloproteinase Inhibitors; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009362:Neoplasm Metastasis / Q000188:drug therapy; D011509:Proteoglycans / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D011509:Proteoglycans; C034666:propionamide