Wilms' tumor in adults: aspiration cytology and cytogenetics.
The fine-needle aspiration cytologic findings of Wilms' tumor occurring in a 20-yr-old female patient and a 35-yr-old male patient showing blastemal, spindled sarcomatous and rare epithelial components are reported. The male patient had the typical presentation of renal mass with metastasis to lung and pleura, whereas the female patient had an unusual presentation with the tumor originated from the subcapsular nephrogenic zone of the kidney, extending into the liver without invasion into the renal cortex. Cytogenetic analysis of this case identified: 90, XXXX, +2x3-4, -5, -15, -16, -17, -17, i (17)(q10) x2. This finding may represent a genetic change associated with Wilms' tumor of older pediatric and young adult patients. To the best of our knowledge, this case is the sixth case with cytogenetic study and the first case revealing isochromosome 17q of an adult Wilms' tumor.
Li
Peng
P
Department of Pathology, New York University School of Medicine, New York, New York, USA.
Perle
Mary Ann
MA
Scholes
John V
JV
Yang
Grace C H
GC
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle; D017024:Chemotherapy, Adjuvant; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008113:Liver Neoplasms / Q000235:genetics / Q000556:secondary* / Q000628:therapy; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary* / Q000628:therapy; D008297:Male; D009392:Nephrectomy; D010997:Pleural Neoplasms / Q000235:genetics / Q000556:secondary* / Q000628:therapy; D009396:Wilms Tumor / Q000235:genetics / Q000556:secondary* / Q000628:therapy