Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress.
We have recently demonstrated that exposure to a single session of inescapable shock (IS), but not to identical amounts and distributions of escapable shock (ES), increases the rewarding properties of morphine, as measured by conditioned place preference (CPP). Interestingly, we also found that exposure to IS has no effect, or even interferes with amphetamine CPP. The present study explored whether the potentiating effect of IS on morphine reward, but not amphetamine reward, would generalize to the locomotor properties of these drugs. The locomotor response to morphine and amphetamine was measured 120 h following exposure to either IS or home cage control (HCC) treatment. On test day, the activity of all subjects was measured for 1 h before and 3 h after drug administration. The results demonstrated that exposure to IS potentiated the locomotor response to morphine, while having no effect on the response to amphetamine. An additional study investigated whether the effects of IS on the locomotor properties of morphine were sensitive to stressor controllability, by comparing the influence of IS, ES, or control treatment. Again, IS potentiated the locomotor properties of morphine, while exposure to ES and control treatment had no effect.
Will
Matthew J
MJ
Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, WI 53719, USA. mjwill@facstaff.wisc.edu
Der-Avakian
Andre
A
Pepin
Julie L
JL
Durkan
Brandice T
BT
Watkins
Linda R
LR
Maier
Steven F
SF
D000661:Amphetamine / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000378:metabolism / Q000503:physiopathology*
D000701:Analgesics, Opioid; D018765:Dopamine Uptake Inhibitors; D009020:Morphine; D000661:Amphetamine