[Testosterone and SHBG levels in blood serum in women with anorexia nervosa].
The reports concerning serum levels of sex hormone binding globulin (SHBG) and testosterone in women with anorexia nervosa are controversial and few in number. The aim of the study was to assess the levels of FSH, LH, PRL, unbound and bound testosterone, SHBG, estradiol, free T4, TSH in women with anorexia nervosa. The TFI (testosterone free index) used to assess SHBG ability to bind testosterone was also calculated. The studied group consisted of 29 women with anorexia nervosa: 15 women untreated hormonally and 14 women treated with estrogens and progestagens. The control group consisted of 13 women with regular menstrual cycle being in the first phase of menstrual cycle, with proper body weight and mean age comparable to the patients with anorexia nervosa. No statistically significant differences between studied groups concerning the serum concentration of FSH, LH, PRL, free testosterone, LH/FSH ratio, TSH and free T4 were found. The total testosterone concentration was statistically significantly lower in the group without hormonal therapy, contrary to SHBG concentration, which was higher in the group treated hormonally. Although there are reports about elevated SHBG and free testosterone levels in patients with anorexia nervosa, our study has shown no significant differences between women with untreated hormonally anorexia nervosa and healthy control group.
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Katedra i Klinika Endokrynologii Ginekologicznej Slaskiej Akademii Medycznej w Katowicach.
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D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood*; D001835:Body Weight; D016022:Case-Control Studies; D002149:Energy Intake; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011388:Prolactin / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D006065:Gonadotropins, Pituitary; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013974:Thyroxine