Sexual dysfunction secondary to gemfibrozil.
Hypertriglyceridemia is a well-recognized complication of protease inhibitor therapy, specifically ritonavir. Fibrate derivatives are recommended as first-line therapy for isolated triglyceride elevations, and gemfibrozil has been successful for managing protease inhibitor-induced lipid changes. A 35-year-old man experienced sexual dysfunction 3 weeks after starting gemfibrozil. The temporal relationship and improvement in sexual function after the drug was discontinued suggest that gemfibrozil may have been responsible for his sexual dysfunction.
James
Christopher W
CW
HIV Community Program, Christiana Care Health Services, Wilmington, Delaware 19899-1668, USA. cjames@christianacare.org
Wu
Tina S
TS
McNelis
Kelly C
KC
D000328:Adult; D015248:Gemfibrozil / Q000009:adverse effects* / Q000627:therapeutic use; D017320:HIV Protease Inhibitors / Q000009:adverse effects; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010410:Penile Erection / Q000187:drug effects; D019438:Ritonavir / Q000009:adverse effects; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced*
D017320:HIV Protease Inhibitors; D000960:Hypolipidemic Agents; D019438:Ritonavir; D015248:Gemfibrozil