Cell adhesion molecules and adhesion abnormalities in prostate cancer.
Prostate cancer, the leading male cancer in Western countries, has accelerated in its incidence in the past decade. Patients with prostate cancer frequently have a poor prognosis as a result of local or distant spread of cancer. This review summarises some of the recent progress made in understanding the biology of cancer metastasis with a special emphasis on the role of cell adhesion molecules and adhesion abnormalities. The molecular and cellular function of cell adhesion molecules, their role in cancer and cancer progression, the clinical impact of these molecules, and therapeutic considerations are also discussed.
Mason
Malcolm D
MD
Department of Clinical Oncology, University of Wales College of Medicine, Health Park, Cardiff, UK. malcolm.mason@velindre-tr.wales.nhs.uk
Davies
Gaynor
G
Jiang
Wen G
WG
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D018450:Disease Progression; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
D015815:Cell Adhesion Molecules