Synthesis of blood compatible polyamide block copolymers.
Blood compatibility of polyamides has been improved by introducing amido-amine groups in polymer backbone. Polyamide block-copolymer are synthesized by reacting amine end-capped polyamides with N,N'-methylene-bisacrylamide. Polyamide block-copolymers, thus produced found to have the ability of absorbing heparin. Heparinized polyamide block-copolymers have shown significant improvement in blood compatibility as evident from thrombus formation and hemolysis studies.
Singhal
Jai Paul
JP
Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi.
Ray
Alok R
AR
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D001769:Blood; D006493:Heparin; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis* / Q000737:chemistry; D013057:Spectrum Analysis; D013499:Surface Properties; D013927:Thrombosis / Q000517:prevention & control; D014965:X-Rays
D001672:Biocompatible Materials; D009757:Nylons; D006493:Heparin