title: Massive intracerebral aspergillosis responding to combination high dose liposomal amphotericin B and cytokine therapy without surgery.
abstract: This report describes a patient with intracranial Aspergillus flavus infection in whom it was impossible to remove the fungal mass surgically. Progressive fungal infiltration of the optic nerves was reversed and the extensive intracranial fungal burden was managed successfully with combination antifungal-immunomodulatory therapy alone.
authors.forename: M
authors.initials: M
authors.lastname: Ellis
authors.affiliation: Departments of Medicine and ‡Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain and Departments of *Surgery, †Medicine and §Radiology, Tawam Hospital, Al Ain, UAE.
authors.forename: R
authors.initials: R
authors.lastname: Watson
authors.affiliation: Departments of Medicine and ‡Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain and Departments of *Surgery, †Medicine and §Radiology, Tawam Hospital, Al Ain, UAE.
authors.forename: A
authors.initials: A
authors.lastname: McNabb
authors.affiliation: Departments of Medicine and ‡Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain and Departments of *Surgery, †Medicine and §Radiology, Tawam Hospital, Al Ain, UAE.
authors.forename: M L
authors.initials: ML
authors.lastname: Lukic
authors.affiliation: Departments of Medicine and ‡Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain and Departments of *Surgery, †Medicine and §Radiology, Tawam Hospital, Al Ain, UAE.
authors.forename: M
authors.initials: M
authors.lastname: Nork
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000473:pathology; D001231:Aspergillus flavus / Q000187:drug effects / Q000254:growth & development*; D001927:Brain Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016207:Cytokines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008081:Liposomes; D008279:Magnetic Resonance Imaging
chemical_list: D000935:Antifungal Agents; D016207:Cytokines; D008081:Liposomes; D000666:Amphotericin B