Biochemical and behavioral effects of carbofuran in goldfish (Carassius auratus).
The effects of concentration (5, 50, and 500 microg/L) and duration (24, 48 h) of exposure to carbofuran, a carbamate insecticide, were assessed on brain catecholamine (norepinephrine [NE] and dopamine), plasma glucose, and hepatic glycogen contents and behavioral activities of goldfish (Carassius auratus). After 24 h of exposure to 50 and 500 microg/L, the level of NE was increased in the olfactory bulbs. The same effect was observed after a 48-h exposure to 500 and 50 microg/L in the telencephalic hemispheres and in the hypothalamus, respectively. An increase in the level of dopamine was also found in hypothalamus after 48 h of exposure to 500 microg/L carbofuran. Plasma glucose increased in concentration after both periods of exposure to carbofuran at 50 and 500 microg/L. Hepatic glycogen concentration decreased after a 48-h exposure to the highest concentration. Behavioral endpoints related to swimming pattern and social interactions were affected after a 24-h exposure to the lowest concentration tested (5 microg/L). The relative sensitivities of these different types of responses to exposure to carbofuran are discussed in light of data on the neurotoxic effects of carbamate and organophosphate insecticides in fish.
Bretaud
Sandrine
S
Laboratoire d'Ecologie Aquatique, INRA, UMR EQHC, Rennes, France.
Saglio
Philippe
P
Saligaut
Christian
C
Auperin
Benoit
B
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D002235:Carbofuran / Q000633:toxicity*; D004298:Dopamine / Q000378:metabolism; D006054:Goldfish / Q000097:blood / Q000378:metabolism*; D007306:Insecticides / Q000633:toxicity*; D008112:Liver Glycogen / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D001786:Blood Glucose; D007306:Insecticides; D008112:Liver Glycogen; D014874:Water Pollutants, Chemical; D002235:Carbofuran; D004298:Dopamine; D009638:Norepinephrine