Treatment of malignant digestive tract obstruction by combined intraluminal stent installation and intra-arterial drug infusion.
OBJECTIVE
To study the palliative treatment of malignant obstruction of digestive tract with placement of intraluminal stent combined with intra-arterial infusion of chemotherapeutic drugs.


METHODS
A total of 281 cases of digestive tract malignant obstruction were given per oral (esophagus, stomach, duodenum and jejunum), per anal (colon and rectum) and percutaneous transhepatic (biliary) installation of metallic stent. Among them, 203 cases received drug infusion by cannulation of tumor supplying artery with Seldinger's technique.


RESULTS
Altogether 350 stents were installed in 281 cases, obstructive symptoms were relieved or ameliorated after installation. Occurrence of restenotic obstruction was 8-43 weeks among those with intra-arterial drug infusion, which was later than 4-26 weeks in the group with only stent installation. The average survival time of the former group was 43 (3-105) weeks, which was significantly longer than 13 (3-24) weeks of the latter group.


CONCLUSIONS
Intraluminal placement of stent combined with intra-arterial infusion chemotherapy is one of the effective palliative therapies for malignant obstruction of the digestive tract with symptomatic as well as etiological treatment.
Mao
A W
AW
Department of Interventional Radiology, Shanghai S.T, Luke's Hospital, 768 Yu Yuan Road, Shanghai 200050, China. maw1@elong.com
Gao
Z D
ZD
Xu
J Y
JY
Yang
R J
RJ
Xiao
X S
XS
Jiang
T H
TH
Jiang
W J
WJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007415:Intestinal Obstruction / Q000188:drug therapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods; D011788:Quality of Life; D015607:Stents; D016896:Treatment Outcome
D000970:Antineoplastic Agents