A comparison of software packages that assess linkage using a variance components approach.
We report single-point and multipoint results from three statistical genetics software packages using a variance components approach for quantitative traits. When possible, we have shown the effects of covariates. Results from GENEHUNTER, SOLAR, and ACT software packages are compared for the quantitative trait immunoglobulin E (IgE) using chromosome 5 asthma familial data from Oxfordshire (England), Perth (Australia), and Freiburg (Germany), and using the genome-wide German data. Although few differences among variance components results for GENEHUNTER, SOLAR, and ACT were detected on a limited region of chromosome 5, these packages showed larger disagreement in the German data for chromosomes 1, 9, and 14.
Atkinson
E J
EJ
Department of Health Sciences Research, Section of Biostatistics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Hall
D
D
de Andrade
M
M
D000328:Adult; D000704:Analysis of Variance; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D001315:Australia; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002895:Chromosomes, Human, Pair 5; D003431:Cross-Cultural Comparison; D004739:England; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005858:Germany; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008432:Mathematical Computing; D008957:Models, Genetic; D019655:Quantitative Trait, Heritable; D012984:Software
D005819:Genetic Markers; D007073:Immunoglobulin E