[Anticipated and unexpected physiological effects of oligopeptides (glyprolines, ACTH (4-10) analogs, taftsin, and thyroliberin)].
A short review of investigations resulting in determination of a new family of regulatory peptides (glyprolines) participating in modulation of hemostasis and protection of mucous membranes, obtaining of the ACTH4-10 new analogues which are potent neuroprotectors and nootrops, and revealing of unexpected biological activities of some other peptides (behavioural effects of tuftsin, lymph flow stimulation by thyroliberin, etc.). Further investigations into the functional peptide continuum is discussed.
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M. V. Lomonossov State University, 119899, Vorobievy Gory, Moscow, Russia.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006801:Humans; D015213:Neuroimmunomodulation / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D014405:Tuftsin / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000897:Anti-Ulcer Agents; D000925:Anticoagulants; D004151:Dipeptides; D005343:Fibrinolytic Agents; D018696:Neuroprotective Agents; D018697:Nootropic Agents; D009842:Oligopeptides; D010446:Peptide Fragments; D013973:Thyrotropin-Releasing Hormone; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10); D014405:Tuftsin