[Non-autoimmune fulminant type 1 diabetes].
A new classification for diabetes mellitus based on ethiology was proposed by the Japan Diabetes Association in 1999. According to the classification, type 1 diabetes was subclassified as type 1A(autoimmune based) and type 1B(idiopathic). However, the latter is considered to be heterogeneous. Recently, a novel subtype of type 1B diabetes mellitus has been reported. In this review, a summary account of this new subtype is given. The patients in this subgroup have a non-autoimmune, fulminant disorder characterized by the absence of insulitis and of diabetes-related antibodies, a remarkably abrupt onset, and high serum pancreatic enzyme concentrations.
Sanke
T
T
Department of Clinical Laboratory Medicine, Wakayama Medical University, Wakayama 641-8509.
D000681:Amylases / Q000097:blood; D001323:Autoantibodies; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000145:classification* / Q000209:etiology / Q000503:physiopathology; D005968:Glutamate Decarboxylase / Q000276:immunology; D006442:Glycated Hemoglobin / Q000172:deficiency; D006801:Humans
D000681:Amylases; D001323:Autoantibodies; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases; D005968:Glutamate Decarboxylase; D006442:Glycated Hemoglobin