title: A cycle of enzymatic reactions that behaves like a neuronal circuit.
abstract: A cycle of four enzymatic reactions with repression or allosteric inhibition of the enzymes has been proposed by analogy to a neural oscillator. The system is analysed in a situation remote from full symmetry. Asymmetry has been introduced by treating one of the reagents as a reservoir substance with constant concentration and having essentially different rate constants for forward and backward reactions. It is demonstrated that, for certain values of parameters, the system can work as a strength of stimulus to frequency transducer. For other values of the parameters, it acquires the features of an excitable system.
authors.affiliation: Department of Biophysics, Institute of Physics, Maria Curie-Sklodowska University, Pl. M. Curie-Sklodowska 1, 20-031 Lublin, Poland. sielew@tytan.umcs.lublin.pl
authors.forename: Jan
authors.initials: J
authors.lastname: Sielewiesiuk
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Malarczyk
mesh_terms: D000818:Animals; D004798:Enzymes / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D010636:Phenols / Q000378:metabolism*; D012240:Rhodococcus / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D004798:Enzymes; D010636:Phenols