title: Excretion rate of progesterone in milk and faeces in lactating dairy cows with two levels of milk yield.
abstract: This study was conducted to measure the effect of the level of daily milk yield on the excretion rate of progesterone (P4) in milk and faeces in high-producing (HP) and low-producing (LP) lactating dairy cows. A GnRH-agonist was implanted to block endogenous production of P4. A CIDR device was inserted into the vagina and left in place for 11 days. The average and peak milk yields were greater in HP cows (P < 0.0001). Mean plasma concentrations of P4 were also similar in both groups (P = 0.44), even though the average mass of P4 delivered from a CIDR device was higher with HP cows (P = 0.02). Average milk P4 concentration was similar in both groups (P = 0.81), so that average daily excretion of P4 in the milk was greater with HP cows (P = 0.05). The concentrations (P = 0.83) and daily yields (P = 0.4) of total faecal progesterone metabolites were not affected by level of milk yield. These data show that the concentrations of plasma and milk P4, and the concentration and yield of P4 metabolites are not affected by the levels of daily milk yield.
authors.affiliation: Department of Veterinary Science, University of Melbourne, Werribee, Victoria, Australia. a.rabiee@vet.unimelb.edu.au
authors.forename: A R
authors.initials: AR
authors.lastname: Rabiee
authors.forename: K L
authors.initials: KL
authors.lastname: Macmillan
authors.forename: F
authors.initials: F
authors.lastname: Schwarzenberger
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D002417:Cattle / Q000378:metabolism / Q000502:physiology*; D004343:Drug Implants; D005243:Feces / Q000737:chemistry*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000819:agonists / Q000031:analogs & derivatives*; D007774:Lactation; D008892:Milk / Q000737:chemistry* / Q000378:metabolism; D011374:Progesterone / Q000097:blood / Q000378:metabolism*; D017329:Triptorelin Pamoate / Q000031:analogs & derivatives
chemical_list: D004343:Drug Implants; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; C066438:deslorelin