Effect of IL-15 on the secretion of IL-1beta, IL-1Ra and sIL-1RII by PMN from cancer patients.
In the present study, we demonstrate an effect of rhIL-15 on the simultaneous secretion of IL-1beta and its natural inhibitors IL-1Ra and sIL-1RII by human neutrophils isolated from normal and tumour-bearing hosts (oral cavity cancer and melanoma patients) compared with serum IL-15 levels. We found an rhIL-15 influence on IL-beta and IL-1Ra secreted by PMN from healthy controls. In contrast, the PMNs from cancer patients were not sensitive to rhIL-15 stimulation. However, we found a priming effect of rhIL-15 on IL-1beta production by LPS-stimulated cells in oral cavity cancer. We also found no effect on sIL-1RII release by PMN from cancer patients.
Jablonska
E
E
Department of Immunology, Medical Academy of Bialystok, Poland. ewaj@amb.ac.bialystok.pl
Piotrowski
L
L
Kiluk
M
M
Jablonski
J
J
Grabowska
Z
Z
Markiewicz
W
W
D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000276:immunology; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000378:metabolism*; D019409:Interleukin-15 / Q000276:immunology* / Q000494:pharmacology; D008545:Melanoma / Q000097:blood / Q000276:immunology; D009062:Mouth Neoplasms / Q000097:blood / Q000276:immunology; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000096:biosynthesis*; D011994:Recombinant Proteins / Q000494:pharmacology; D012795:Sialoglycoproteins / Q000378:metabolism*; D014407:Tumor Cells, Cultured
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D019409:Interleukin-15; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins; D012795:Sialoglycoproteins