title: Complication profiles of adult asthmatics requiring paralysis during mechanical ventilation.
abstract: OBJECTIVE
  To assess the characteristics and the incidence of morbidity of intubated asthmatic patients who received long-term paralysis.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Five intensive care units (ICUs) in Paris and the surrounding suburbs.
  
  
  METHODS
  The NMB group consisted of patients who received neuromuscular blocking agents for more than 12 h (NMB group) versus sedation alone (SED).
  
  
  METHODS
  None.
  
  
  RESULTS
  The incidence of post-extubation muscle weakness and/or myopathy was 18% in the NMB group compared to 2% in the SED group ( p=0.01). The occurrence of ventilator-associated pneumonia was higher in the NMB group (42% versus 4%; p<0.0001). The duration of ICU stay and of mechanical ventilation were significantly greater in the NMB group. Multiple logistic regression analysis showed that inclusion in the NMB group was the only independent predictor of the presence of the overall morbidity [odds ratio 6.4 (2.09; 19.64)].
  
  
  CONCLUSIONS
  While greater initial severity of respiratory compromise in the NMB group may explain part of the difference, use of NMB agents appears to be strongly related to the presence of significant complications among mechanically-ventilated asthmatic patients.
authors.affiliation: SAMU 93, Hôpital Avicenne, Université Paris XIII, 93009 Bobigny Cedex, France. frederic.adnet@avc.ap-hop-paris.fr
authors.forename: F
authors.initials: F
authors.lastname: Adnet
authors.forename: G
authors.initials: G
authors.lastname: Dhissi
authors.forename: S W
authors.initials: SW
authors.lastname: Borron
authors.forename: M
authors.initials: M
authors.lastname: Galinski
authors.forename: F
authors.initials: F
authors.lastname: Rayeh
authors.forename: M
authors.initials: M
authors.lastname: Cupa
authors.forename: J L
authors.initials: JL
authors.lastname: Pourriat
authors.forename: F
authors.initials: F
authors.lastname: Lapostolle
mesh_terms: D000328:Adult; D001249:Asthma / Q000401:mortality / Q000628:therapy*; D016009:Chi-Square Distribution; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects*; D009468:Neuromuscular Diseases / Q000139:chemically induced*; D012121:Respiration, Artificial / Q000379:methods*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D009466:Neuromuscular Blocking Agents