Statistical design and application to combinatorial chemistry.
Combinatorial chemistry has matured from its early production-belt image of synthesizing the maximum number of compounds in the minimum amount of time. It is now a discovery technology driven by good experimental design, with a focus on producing high numbers of quality drug-like compounds. Complex statistical and optimization algorithms are routinely applied to ensure that the library is designed with the best chance of achieving its goals, while also facilitating efficient synthesis.
Rose
Sally
S
BioFocus, Sittingbourne Research Centre, Sittingbourne, UK ME9 8AZ. srose@biofocus.co.uk
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D015233:Models, Statistical