[Effects of somatostatin and its analogue on canine sphincter of Oddi motility].
OBJECTIVE
To investigate the effects of somatostatin and its synthetic analogue on canine sphincter of Oddi interdigestive motility.


METHODS
Six dogs were used to establish the chronic manometry model to study the sphincter of Oddi motility, which were then classified into three groups: somatostatin, stilamin, and sandostatin groups. Each dog was studied weekly. The sphincter of Oddi manometry in fast and conscious state was undertaken with PC Polygraf HR before and after intravenous administration of agents to record the motility index (MI), basal pressure, and amplitude, duration and frequency of phasic contraction.


RESULTS
Administration of somatostatin and stilamin of 0.5 nmol.kg(-1).h(-1) dose could induce phasic contraction of sphincter of Oddi and increase MI. The above two agents of 1 nmol.kg(-1).h(-1) dose could inhibit contractile activity of sphincter and decrease MI. Sandostatin of 0.5-1 nmol.kg(-1).h(-1) dose could induce phasic contraction of sphincter of Oddi; however, the agent of 0.5 nmol.kg(-1).h(-1) dose increased MI while 1 nmol.kg(-1).h(-1) dose had no effect on M.


CONCLUSIONS
Effects of somatostatin and stilamin are biphasic in the regulation of sphincter of Oddi motility; small dose of the agents stimulates the sphincter motility while large dose inhibits the motility. Sandostatin regulates the sphincter of Oddi motility; the agent of small dose exerts excitatory role while large dose plays no significant role.
Wang
C
C
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Lu
X
X
Chen
Y
Y
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D015282:Octreotide / Q000494:pharmacology; D013004:Somatostatin / Q000031:analogs & derivatives / Q000494:pharmacology*; D009803:Sphincter of Oddi / Q000187:drug effects* / Q000502:physiology
D013004:Somatostatin; D015282:Octreotide