[Transformation of mycosis fungoides to pleomorphic T-cell lymphoma and central nervous system involvement].
BACKGROUND
Although mycosis fungoides is a malignant T-cell lymphoma involving mainly the skin, neurological complications are possible, with a poor prognosis.


METHODS
A 59-year-old man, treated for mycosis fungoides with transformation to a pleomorphic T-cell lymphoma for 1 year, was seen for mental status changes with confusion. A brain parenchyma localisation was found.


CONCLUSIONS
This observation emphasizes the exceptional neurological tropism in the patients with mycosis fungoides. A transformation to a more aggressive cutaneous T-cell lymphoma seems necessary to induce a central nervous system involvement.
Guilloton
L
L
Service de neurologie, hôpital d'instruction des armées Desgenettes, 108, boulevard Pinel, 69275 Lyon, France. laurent guilloton@santesurf.com
Drouet
A
A
Estival
J L
JL
Saint Pierre
G
G
Dupin
M
M
Ribot
C
C
D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D009182:Mycosis Fungoides / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology; D013997:Time Factors