title: Impairment in frontal but not temporal components of mismatch negativity in schizophrenia.
abstract: Impairment in mismatch negativity (MMN) potentials is a robust finding in schizophrenia. While previous studies suggested that MMN in man is generated by a single dipole source bilaterally in the primary auditory cortex, more recent data modified this assumption by showing differential modulation of MMN components over the frontal and temporal scalp. Here we used a roving standard experiment to record mismatch potentials to tone duration deviants with the aim to detect robust temporal and frontal mismatch components. Fourteen schizophrenic patients with normal intelligence and without overt cognitive deficits and age- and sex-matched controls were studied. In agreement with previous findings MMN recorded from the frontal scalp was markedly attenuated in patients. However, in contrast to previous reports, positive mismatch potentials of normal magnitude were recorded from temporal (mastoid) electrodes. This finding raises the possibility of a selective impairment in multiple mismatch generators in schizophrenia and may lend support for the notion of impaired cortico-cortical connectivity in schizophrenia.
authors.affiliation: Institute of Child Health and Great Ormond Street Hospital, Wolfson Centre, Mecklenburgh Square, WC1N 2AP, London, UK. t.baldeweg@ich.ucl.ac.uk
authors.forename: Torsten
authors.initials: T
authors.lastname: Baldeweg
authors.forename: Anthony
authors.initials: A
authors.lastname: Klugman
authors.forename: John H
authors.initials: JH
authors.lastname: Gruzelier
authors.forename: Steven R
authors.initials: SR
authors.lastname: Hirsch
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D003071:Cognition; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000503:physiopathology*