Organogenesis--heart and blood formation from the zebrafish point of view.
Organs are specialized tissues used for enhanced physiology and environmental adaptation. The cells of the embryo are genetically programmed to establish organ form and function through conserved developmental modules. The zebrafish is a powerful model system that is poised to contribute to our basic understanding of vertebrate organogenesis. This review develops the theme of modules and illustrates how zebrafish have been particularly useful for understanding heart and blood formation.
Thisse
Christine
C
Institut de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université Louis Pasteur, 1 rue Laurent Fries, BP 163, 67404 Illkirch Cedex, C. U. de Strasbourg, France.
Zon
Leonard I
LI
D000818:Animals; D001808:Blood Vessels / Q000196:embryology*; D019521:Body Patterning; D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology* / Q000502:physiology; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D009024:Morphogenesis / Q000235:genetics; D009154:Mutation; D013234:Stem Cells / Q000502:physiology; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics* / Q000378:metabolism