Antifungal activity of benzoic acid derivatives from Piper lanceaefolium.
Bioactivity-guided fractionation of a methanol extract from the leaves of Piper lanceaefolium resulted in the isolation of four new benzoic acid derivatives (1-4), together with taboganic acid, pinocembrin, and pinocembrin chalcone. Lanceaefolic acid methyl ester (3) and pinocembrin chalcone displayed activity against Candida albicans with a minimal inhibitory concentration value of 100 microg/mL in both cases.
López
Andrés
A
Department of Botany, University of British Columbia, #3529-6270 University Boulevard, Vancouver, B.C., Canada V6T 1Z4.
Ming
Dong Sheng
DS
Towers
G H Neil
GH
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002855:Chromatography, Thin Layer; D003105:Colombia; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D026321:Piperaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D018675:Toxicity Tests
D000935:Antifungal Agents; D001565:Benzoates; D044950:Flavanones; D005419:Flavonoids; C016063:pinocembrin