title: Effects of chronic administration of sarpogrelate on systolic blood pressure of spontaneously hypertensive rats: comparison with quinapril.
abstract: Effects of long-term sarpogrelate (5-HT(2) antagonist) administration on the systolic blood pressure of Wistar-Kyoto normotensive rats (WKYs) and spontaneously hypertensive rats (SHRs) were studied and compared with those of quinapril (ACE-I). Sarpogrelate and quinapril were administered orally for 12 weeks and body and heart weights, systolic blood pressure and the relationships between heart weight and systolic blood pressure were determined. Although both drug treatments caused decreases in the body weight of WKYs and SHRs, only quinapril induced a decrease in the heart weight of SHRs. In addition, quinapril induced a dose-dependent decrease in systolic blood pressure in WKYs and SHRs while sarpogrelate had no effect on systolic blood pressure. Thus, quinapril showed hemodynamic effects on WKYs and SHRs, but the 5-HT(2) antagonists sarpogrelate did not shown such effects, suggesting that 5-HT(2) receptor antagonists may not be important for controlling systolic blood pressure.
authors.affiliation: Department of Pharmacology, Niigata College of Pharmacy, 5-13-2 Kamishinei-cho, Niigata 950-2081, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Setoguchi
authors.forename: Toshio
authors.initials: T
authors.lastname: Ohnuki
authors.forename: Mamunur
authors.initials: M
authors.lastname: Rashid
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Kaoru
authors.initials: K
authors.lastname: Hattori
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nagatomo
authors.forename: Kenichi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Akio
authors.initials: A
authors.lastname: Mitomi
authors.forename: Mikio
authors.initials: M
authors.lastname: Nakazawa
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007546:Isoquinolines / Q000494:pharmacology* / Q000627:therapeutic use; D000077583:Quinapril; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D013386:Succinates / Q000494:pharmacology* / Q000627:therapeutic use; D044005:Tetrahydroisoquinolines; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007546:Isoquinolines; D012702:Serotonin Antagonists; D013386:Succinates; D044005:Tetrahydroisoquinolines; C064294:sarpogrelate; D000077583:Quinapril