title: DNA-catalyzed polymerization.
abstract: Native DNA oligomers are shown to be stereoselective catalysts for the polymerization of 5'-amino-3'-acetaldehyde-modified thymidine/adenosine nucleosides through reductive amination. The reaction follows step-growth kinetics to read the encoded sequence and chain-length information in the antiparallel direction. Single mismatches in the template are selected against at a level of >100:1. A method is therefore established to translate biopolymer-encoded information stereoselectively into sequence- and chain-length specific synthetic polymers.
authors.affiliation: Department of Chemistry, Emory University, Emerson Hall, Atlanta, Georgia 30322, USA.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.forename: Zheng-Yun J
authors.initials: ZY
authors.lastname: Zhan
authors.forename: Rachel
authors.initials: R
authors.lastname: Knipe
authors.forename: David G
authors.initials: DG
authors.lastname: Lynn
mesh_terms: D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry*; D007700:Kinetics; D013237:Stereoisomerism; D013379:Substrate Specificity; D013698:Templates, Genetic
chemical_list: D004247:DNA