[Association of HLA-DRB1 genes with pulmonary tuberculosis].
OBJECTIVE
To assess the association of HLA-DRB1 genes with pulmonary tuberculosis (PTB) and the correlation between HLA-DRB1 alleles and clinical manifestations of patients with PTB.


METHODS
Alleles at the HLA-DRB1 typing were analyzed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 74 patients and 90 healthy controls.


RESULTS
Compared with controls, a significant increased frequency of DRB1 * 15 was found (34.3% vs 17.0%, Pc < 0.05, RR = 2.91). The frequency of DRB1 * 12 was also increased, but the difference was not statistically significant(15.4% vs 7.5%, Pc > 0.05). The frequency of DRB1 * 11 was significantly decreased (1.4% vs 9.9%, Pc < 0.05, RR = 0.12). More retreated and drug-resistant cases were found in DRB1 * 15 positive patients than in DRB1 * 15 negative patients.


CONCLUSIONS
These results show that HLA-DRB1 * 15 allele is susceptible gene in PTB, DRB1 * 11 may be a protective allele, HLA-DRB1 * 15 allele may be related to patients with refractory PTB.
Wang
J
J
Biochemical Lab, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing 101149, China.
Song
C
C
Wang
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China; D005260:Female; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000276:immunology
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains