title: Combinatorial bio/chemical analysis of dioxin and dioxin-like compounds in waste recycling, feed/food, humans/wildlife and the environment.
abstract: The present review describes international activities using bioassays/biomarkers in combination with chemical analysis to measure the effects of dioxin and dioxin-like compounds (DLCs) in the environment. The above authors reviewed already the state-of-art bioanalytical detection methods (BDMs) for dioxins and DLCs [Environ Int (2001)]. The aim of this study will be to review applications of these bioassays/biomarkers to evaluate potential dioxins and DLCs. The present literature study lists relative potencies (REPs) of polyhalogenated dibenzo-p-dioxins and -furans (PXDD/Fs; X = Cl, Br, F), their thio analogues polychlorinated dibenzothiophenes (PCDTs) and thianthrens (PCTAs), polyhalogenated biphenyls (PXBs), polychlorinated naphthalenes (PCNs) and other Ah receptor agonists measured by several biodetectors (Tier 3 screening). The authors will discuss some examples of the applications of some of these biodetectors in biomonitoring programmes and recently occurred dioxin crisis in feed/food. The diagnosis of the biopotency of these pollutants in technical processes like thermally treated waste, waste water treatment, landfill leachate treatment, commercial PCB-mixtures, the release into the environment (soil, air and water) and the final intake into wildlife and humans will be reviewed.
authors.affiliation: Life Science Research Laboratories, Kaneka Corporation, Takasago, Japan. behnisch@takaken.kaneka.co.jp
authors.forename: P A
authors.initials: PA
authors.lastname: Behnisch
authors.forename: K
authors.initials: K
authors.lastname: Hosoe
authors.forename: S
authors.initials: S
authors.lastname: Sakai
mesh_terms: D000821:Animal Feed; D000818:Animals; D000835:Animals, Wild; D001681:Biological Assay / Q000379:methods*; D015415:Biomarkers / Q000032:analysis*; D003247:Conservation of Natural Resources; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004147:Dioxins / Q000032:analysis*; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D004790:Enzyme Induction; D005506:Food Contamination; D006801:Humans; D007246:Infertility / Q000209:etiology; D011634:Public Health; D014881:Water Supply
chemical_list: D015415:Biomarkers; D004147:Dioxins; D003577:Cytochrome P-450 Enzyme System