title: Computational models of cardiovascular function for analysis of post-flight orthostatic intolerance.
abstract: The work presented in this paper is part of an ongoing effort to use mathematical models to investigate the effects of microgravity on the cardiovascular system. In particular, a thirteen compartment lumped parameter representation of the cardiovascular system is used to simulate some of the current hypotheses concerning the mechanism of post-flight orthostatic intolerance. Simulations are compared to astronaut stand test data pre - and post-flight in an effort to quantitatively evaluate alternative hypotheses.
authors.affiliation: Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: T
authors.initials: T
authors.lastname: Heldt
authors.forename: E B
authors.initials: EB
authors.lastname: Shim
authors.forename: R D
authors.initials: RD
authors.lastname: Kamm
authors.forename: R G
authors.initials: RG
authors.lastname: Mark
mesh_terms: D000337:Aerospace Medicine; D001794:Blood Pressure / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology*; D008955:Models, Cardiovascular; D013026:Space Flight; D018667:Tilt-Table Test; D014893:Weightlessness / Q000009:adverse effects*