Preparation and characterization of cyclodextrin polymer and its high-performance liquid-chromatography stationary phase.
Cyclodextrin (CD) polymers were synthesized from the reaction of native CDs with a hexamethylene diisocyanate (HDI) compound in a dried DMF solution. The obtained CD polymer contained a range of 8-14% N due to HDI by elemental analysis. The physical and chemical properties of the CD polymers were characterized by IR, solid state 13C NMR, TGA, and DSC, respectively. An HPLC column was prepared using the CD polymer with a carbamate linker by a slurry method. Separation of the phenol isomers was conducted using the CD polymer stationary phase and CD by HPLC. Furthermore, an inclusion complex of the phenol isomer was studied by FT-Raman spectroscopy. From the HPLC and FT-Raman results, inclusion phenomena of o-, m-, and p-nitrophenol onto CD and CD polymers were analyzed.
Lee
Kwang-Pill
KP
Department of Chemistry Graduate School, Kyungpook National University, Taegu, Korea. kplee@knu.ac.kr
Choi
Seong-Ho
SH
Ryu
Eun-Nyoung
EN
Ryoo
Jae Jeong
JJ
Park
Jung Hag
JH
Kim
Yongseong
Y
Hyun
Myung Ho
MH
D002152:Calorimetry, Differential Scanning; D002236:Carbohydrate Conformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods
D003505:Cyclodextrins