[Subreum efficacy and tolerance in patients with early rheumatic arthritis].
OBJECTIVE
To evaluate effectiveness and tolerance of subreum in early rheumatoid arthritis (RA).


METHODS
44 patients with early rheumatoid arthritis. Subreum was given as a single drug and in combination with other basic drugs. Tolerance was evaluated in all the examinees, the effect--in 13 patients who finished the 6-month treatment by the articular syndrome, by ACR, DAS and HAQ criteria.


RESULTS
By DAS, a good response was achieved in 2 patients (15%), a satisfactory one--in 3 (23%) patients. By ACR criteria, a 20% and 50% improvement was obtained in 3 (23%) and 4 (31%) patients. Side effects were absent in 41 (93%) patients.


CONCLUSIONS
Subreum proved effective and well tolerable in early RA.
Stepanets
O V
OV
Chichasova
N V
NV
Nasonova
M B
MB
Nasonov
E L
EL
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000367:Age Factors; D000942:Antigens, Bacterial / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; C050501:OM 89