Exploiting linkage disequilibrium in population isolates.
A comparison of haplotype frequencies between unrelated cases and controls from population isolates identifies a strong signal for the presence/absence of the discrete phenotype in an interval on chromosome 6 bounded by markers 34 and 35. We define a dissimilarity index, D, which is sensitive to differences in allele distributions and differences in the patterns of linkage disequilibrium between cases and controls. We describe two statistical methods to utilize D: a method appropriate for a single moderately sized sample and a sequential approach appropriate for multiple small independent samples.
Culverhouse
R
R
Department of Psychiatry, Washington University School of Medicine, Box 8134, Dept. of Psychiatry, 660 South Euclid, St. Louis, MO 63110, USA.
Lin
J
J
Liu
K Y
KY
Suarez
B K
BK
D000483:Alleles; D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D010641:Phenotype
D005819:Genetic Markers