Cutaneous leucocytoclastic vasculitis associated with omeprazole.
Omeprazole is a potent proton pump inhibitor and usually is well tolerated. Adverse effects of this drug have been reported in up to 5% of patients, most of which are trivial and disappear rapidly on discontinuation of the drug. Skin adverse reactions attributed to omeprazole are uncommon and include rashes, urticaria, angio-oedema, acute disseminated epidermal necrolysis, lichen spinulosus, and contact dermatitis. Cutaneous leucocytoclastic vasculitis (CLV) has not been previously reported in association with omeprazole. The development of CLV in an elderly patient four weeks after starting treatment with omeprazole is described.
Odeh
M
M
Department of Internal Medicine B, Bnai Zion Medical Center, and Technion Faculty of Medicine, Israel.
Lurie
M
M
Oliven
A
A
D000368:Aged; D000897:Anti-Ulcer Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D004381:Duodenal Ulcer / Q000188:drug therapy; D005260:Female; D006801:Humans; D009853:Omeprazole / Q000009:adverse effects* / Q000627:therapeutic use; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000473:pathology
D000897:Anti-Ulcer Agents; D009853:Omeprazole