Newly developed aminopropyl-silicate immunoisolation membrane for a microcapsule-shaped bioartificial pancreas.
An aminopropyl-silicate membrane, synthesized from tetramethoxysilane (TMOS) and 3-aminopropyltrimethoxysilane (APTrMOS) by the sol-gel method, was formed onto Ca-alginate gel beads via electrostatic interactions. The permeability of the membrane could be controlled easily by changing the molar ratio of both the precursors ([APTrMOS]/[TMOS]). The aminopropyl-silicate membrane prepared at a molar ratio of 2.40 rejected gamma-globulin and BSA successfully, whereas it permeated ovalbumin. This result indicates that the molecular weight cutoff point of this newly developed aminopropyl-silicate membrane is approximately 60 kDa.
Sakai
S
S
Department of Materials Process Engineering, Graduate School of Engineering, Kyushu University, Fukuoka, Japan. sakai@chem_eng_kyushu-u.ac.jp
Ono
T
T
Ijima
H
H
Kawakami
K
K
D021522:Bioartificial Organs; D008567:Membranes, Artificial; D019397:Pancreas, Artificial; D010539:Permeability; D012822:Silicon Dioxide
D008567:Membranes, Artificial; C021611:aminopropyl silica gel; D012822:Silicon Dioxide