Antidiabetic effect of Cogent db, a herbal drug in alloxan-induced diabetes mellitus.
Cogent db, a compound herbal drug, was investigated for its possible antidiabetic effect in alloxan-induced diabetic rats. Oral administration of 0.15, 0.30 and 0.45 g/kg body wt. of the aqueous solution of Cogent db for 40 days exhibited a significant reduction in blood glucose, glycosylated haemoglobin and increased plasma insulin, total haemoglobin along with antihyperlipidemic effects in diabetic rats. The effective dose was found to be 0.45 g/kg body wt. It also prevents body weight loss in diabetic rats. An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats in which there was a significant improvement in glucose tolerance in rats treated with Cogent db. A comparison was made between the action of Cogent db and a known antidiabetic drug--glibenclamide (600 microg/kg body wt.). The antidiabetic effect of Cogent db was more effective than that observed with glibenclamide.
Pari
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Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, 608 002, Tamil Nadu, India. paribala@sancharnet.in
Saravanan
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G
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D006454:Hemoglobins / Q000378:metabolism; D029001:Herbal Medicine; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D028321:Plant Preparations; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D006454:Hemoglobins; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D028321:Plant Preparations; C450063:cogent db; D000496:Alloxan