title: Nonhypertensive cardiac effects of a high salt diet.
abstract: Dietary salt intake plays a major role in variation of blood pressure levels and cardiovascular conditions. High salt intake is associated with the occurrence of hypertension. The evidence that high salt intake increases risk of cardiovascular disease is inconsistent. Some studies indicate a significant and positive association between salt intake and risk of cardiovascular disease, whereas several other studies report that such an association may not exist and that low sodium may even be harmful. It is clear that left ventricular hypertrophy is closely related to salt intake. There is evidence indicating that high salt intake increases renal glomerular filtration rate and glomerular filtration fraction in salt-sensitive patients. The association of high salt intake, insulin resistance, and salt sensitivity, and the interaction between high salt intake, heart rate, and blood pressure are debated.
authors.affiliation: Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. hu.gang@ktl.fi
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
authors.forename: Qing
authors.initials: Q
authors.lastname: Qiao
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D012982:Sodium, Dietary / Q000009:adverse effects*
chemical_list: D012982:Sodium, Dietary