[Possibilities for an individualized approach to the treatment of climacteric symptoms with phytoestrogens].
In climacteric women with contraindications and fear or lack of compliance for taking hormonal replacement therapy as well as in those cases where risks exceed benefits, the use of phytoestrogens is appropriate having in mind their especially good effect on neurovegetative symptoms.


OBJECTIVE
The present randomized prospective study is aimed at estimating the possibility for ameliorating climacteric symptoms with Melbrosia and at assessment of its effect on different symptoms in order to individualize the therapeutical approach.


METHODS
Two groups of women with climacteric complaints were followed-up--control group (n = 32) and treatment group (n = 34). Climateric symptoms were assessed in the beginning and at the end of the study using Kupperman menopausal index. The levels of FSH, LH, oestradiol as well as some parameters of lipid metabolism were determined.


RESULTS
A significant decrease of Kupperman index was observed in Melbrosia treatment group in contrast to the control group. No significant changes in gonadotropins, oestradiol and lipid parameters were found in both groups.


CONCLUSIONS
The preparation Melbrosia, consisting of phytoestrogens and amino acids exerts a good therapeutic effect on climacteric symptoms mainly on the nervousness, anxiety, irritability, headache, and hot flashes.
Kolarov
G
G
Nalbanski
B
B
Kamenov
Z
Z
Orbetsova
M
M
Georgiev
S
S
Nikolov
A
A
Marinov
B
B
D000596:Amino Acids / Q000627:therapeutic use*; D002979:Climacteric / Q000187:drug effects* / Q000502:physiology; D004968:Estrogens, Non-Steroidal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D011446:Prospective Studies
D000596:Amino Acids; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations