DNA-catalyzed polymerization.
Native DNA oligomers are shown to be stereoselective catalysts for the polymerization of 5'-amino-3'-acetaldehyde-modified thymidine/adenosine nucleosides through reductive amination. The reaction follows step-growth kinetics to read the encoded sequence and chain-length information in the antiparallel direction. Single mismatches in the template are selected against at a level of >100:1. A method is therefore established to translate biopolymer-encoded information stereoselectively into sequence- and chain-length specific synthetic polymers.
Li
Xiaoyu
X
Department of Chemistry, Emory University, Emerson Hall, Atlanta, Georgia 30322, USA.
Zhan
Zheng-Yun J
ZY
Knipe
Rachel
R
Lynn
David G
DG
D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry*; D007700:Kinetics; D013237:Stereoisomerism; D013379:Substrate Specificity; D013698:Templates, Genetic
D004247:DNA