[Comparison of HOMA IR with the minimal model for measuring insulin sensitivity in polycystic ovary syndrome].
BACKGROUND
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of premenopausal women. These women have insulin resistance independent of obesity; and insulin resistance is now recognized as a risk factor for the development of type 2 diabetes mellitus, hypertension and cardiovascular disease.


OBJECTIVE
We sought, therefore, to assess whether there was correlation between a simple fasting measure of insulin sensitivity (Homeostatic Model) and the Minimal-Model in this syndrome.


METHODS
Thirty-three PCOS women (aged 22.7 +/- 6.2 years and body mass index (BMI) 29.1 +/- 5.4) underwent frequently sampled i.v. glucose tolerance test (Minimal-Model).


RESULTS
Seventeen patients (51.5%) had insulin sensitivity < 1.5 x 10(-4) min.-1.microU-1.mL-1. Patients with BMI > de 27 was more resistant than the BMI < or = de 27 (p = 0.004). The correlation in PCOS between Si (insulin sensitivity) and HOMA IR was found significant for all the group (p = 0.0001; RRANK = -0.76) and those women with BMI > de 27 (RRANK = -0.77; p = 0.00006), but not significant correlation was found in those with BMI < or = de 27 (RRANK = -0.43; p = 0.13).


CONCLUSIONS
We conclude that the HOMA IR may be useful as a screening test for insulin resistance in overweight and obese Mexican PCOS women but not in the lean ones.
Amador
N
N
Espinoza
G
G
Guízar
J M
JM
González
M
M
Alpízar
M
M
D000273:Adipose Tissue / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology; D004198:Disease Susceptibility; D005215:Fasting / Q000097:blood; D005260:Female; D005947:Glucose; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006728:Hormones / Q000097:blood; D006801:Humans; D007258:Informed Consent; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D008954:Models, Biological; D009765:Obesity / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D012307:Risk Factors
D001786:Blood Glucose; D006728:Hormones; D007328:Insulin; D005947:Glucose