title: Regulation of dendritic cell recruitment by chemokines.
abstract: Dendritic cells (DC) are a heterogeneous family of cells that function as sentinels of the immune system. This article summarizes observations suggesting that inflammatory chemokines secreted at the site of pathogen invasion determine the DC subset recruited and influence the class of the immune response initiated. Langerhans cells are selectively recruited by MIP-3alpha/CCL20. In contrast, CCR7 ligands have a key role in the accumulation of antigen-loaded mature DC in T cell-rich areas of the draining lymph node. Improved understanding of the regulation of DC trafficking might offer new opportunities for therapeutic interventions to control immune responses.
authors.affiliation: Schering-Plough, Laboratory for Immunological Research, Dardilly, France. Christophe.Caux@spcorp.com
authors.forename: Christophe
authors.initials: C
authors.lastname: Caux
authors.forename: Béatrice
authors.initials: B
authors.lastname: Vanbervliet
authors.forename: Catherine
authors.initials: C
authors.lastname: Massacrier
authors.forename: Smina
authors.initials: S
authors.lastname: Ait-Yahia
authors.forename: Céline
authors.initials: C
authors.lastname: Vaure
authors.forename: Karine
authors.initials: K
authors.lastname: Chemin
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Dieu-Nosjean
authors.forename: Alain
authors.initials: A
authors.lastname: Vicari
mesh_terms: D000818:Animals; D000917:Antibody Formation; D002453:Cell Cycle; D016922:Cellular Senescence; D018925:Chemokines / Q000502:physiology*; D003713:Dendritic Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans
chemical_list: D018925:Chemokines