[Effect of tsaoko-anemarrhenae decoction on intracerebral c-fos, c-jun mRNA expression in interrupting pentylentetrazol kindled epileptic rat model].
OBJECTIVE
To investigate the molecular biological mechanism of anti-epileptic effect of Tsaoko-Anemarrhenae decoction (TAD) on epileptic model rats.


METHODS
The pentylenetetrazol (PTZ) induced epileptic Sprague-Dawley rats were selected as the animal model. The effects of TAD on the c-fos, c-jun gene expression in the rats' brain were observed by in situ hybridisation.


RESULTS
The c-fos, c-jun gene expression was obviously increased, TAD could effectively block the gene expression of c-fos, c-jun, showing better antiepileptic effect.


CONCLUSIONS
The mechanism of TAD anti-epileptic effect might be correlated to the decrease of c-fos, c-jun gene expression.
Zhang
L
L
Beijing University of Traditional Chinese Medicine, Beijing (100029).
He
J
J
Zhai
S
S
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger; D010433:Pentylenetetrazole