Anticonvulsant and neurotoxicity evaluation of 5-(un)-substituted isatinimino derivatives.
Various Schiff bases were prepared by reacting 5-(un)-substituted isatin with some heterocyclic compounds, viz., N-[4-(4'-chlorophenyl-thiazol-2-yl] semicarbazide, 3-amino-2-methylmercaptoquinazolin-4-one, 3-(4'-pyridyl)-4-amino-5-mercapto-4(H)-1,2,4-triazole and 4-(4'-chlorophenyl)-6-(4"-methylphenyl)-2-aminopyrimidine. The compounds were evaluated for anticonvulsant and neurotoxic properties. The compound 3-(3',4'-dihydro-2'-methylmercapto-4'-oxoquinazolin-3'-yl) iminoisatin (3) emerged as the most active analogue showing anti-MES and anti-PTZ activities better than valproic acid. All the compounds showed lower neurotoxicity than phenytoin and carbamazepine.
Pandeya
S N
SN
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India.
Sriram
D
D
Yogeeswari
P
P
Stables
J P
JP
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D003292:Convulsants / Q000633:toxicity; D004597:Electroshock; D007274:Injections, Intraperitoneal; D007510:Isatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D009498:Neurotoxins / Q000138:chemical synthesis* / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors / Q000633:toxicity; D004856:Postural Balance / Q000187:drug effects; D051381:Rats
D000927:Anticonvulsants; D003292:Convulsants; D009498:Neurotoxins; D007510:Isatin; D010433:Pentylenetetrazole