[LCAT (lecithin:cholesterol acyltransferase)].
Lecithin:cholesterol acyltransferase (LCAT) is an enzyme which converts free cholesterol of lipoprotein into esterified cholesterol. LCAT plays an important role in lipid metabolism especially in the reverse cholesterol transport system. As LCAT protein is synthesized by the liver, patients with liver disease showed a decreased ratio of cholesteryl ester to total cholesterol. Familial LCAT Deficiency and Fish Eye Disease are disorders that lack LCAT activity congenitally.
Kinoshita
M
M
Teikyo University School of Medicine.
Teramoto
T
T
D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000378:metabolism; D004796:Clinical Enzyme Tests / Q000379:methods; D003318:Corneal Opacity / Q000175:diagnosis / Q000209:etiology; D004951:Esterification; D006801:Humans; D007863:Lecithin Cholesterol Acyltransferase Deficiency / Q000175:diagnosis / Q000235:genetics; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood* / Q000502:physiology
D015415:Biomarkers; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase