title: Increased pathology incidence in the forestomach of rats maintained on a diet containing ivermectin and given a single dose of N-methyl-N1-nitro-N-nitrosoguanidine.
abstract: Ivermectin is widely used against parasitic infections in veterinary and human medicine and was found to promote the growth of lesions leading to neoplasia when given continuously in the diet to Wistar rats receiving a single low dose of N-methyl-N1-nitro-N-nitrosoguanidine (MNNG). No tumors or pathological lesions were observed in the forestomach of the control animals or those given ivermectin alone. However, compared to animals receiving MNNG alone, rats maintained on a diet containing ivermectin (2 ppm) and given MNNG (12.5 mg/kg) by gavage showed an increased number of neoplasms (9/26 vs 3/18; p = 0.30) and a statistically significant fourfold increase in the number of pathological lesions (18/26 vs 3/18; p = 0.002), which include preneoplasia in the forestomach. In all cases, the pathological lesions were more severe in the animals receiving ivermectin and MNNG, compared to those receiving MNNG alone.
authors.affiliation: Cancer Research Campaign Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Connor
authors.forename: F
authors.initials: F
authors.lastname: MacNaught
authors.forename: W H
authors.initials: WH
authors.lastname: Butler
authors.forename: D P
authors.initials: DP
authors.lastname: Cooper
authors.forename: G P
authors.initials: GP
authors.lastname: Margison
authors.forename: A C
authors.initials: AC
authors.lastname: Povey
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004032:Diet; D004347:Drug Interactions; D007306:Insecticides / Q000008:administration & dosage / Q000009:adverse effects*; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000009:adverse effects*; D009153:Mutagens / Q000009:adverse effects*; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000662:veterinary; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000662:veterinary
chemical_list: D007306:Insecticides; D009153:Mutagens; D008769:Methylnitronitrosoguanidine; D007559:Ivermectin