title: Pleomorphic liposarcoma metastatic to the thyroid gland.
abstract: Although carcinoma is rarely metastatic to the thyroid gland, it has an established place in the differential diagnosis of cold nodules on radionuclide thyroid scans in patients with known cancers. A case of metastatic pleomorphic liposarcoma with involvement of the thyroid gland adds to the list of cases of metastases to the thyroid gland. A patient with known metastatic pleomorphic liposarcoma with a palpable thyroid nodule of 2 months' duration had a thyroid scan with 130 MBq (3.5 mCi) Tc-99m pertechnetate. The scan showed a cold nodule occupying most of the right lobe of the thyroid. Cytologic analysis of a fine-needle aspirate from this cold nodule confirmed metastasis from the known primary cancer, pleomorphic liposarcoma. In a patient with a known primary tumor, a nodule in the thyroid gland should be considered a metastatic lesion, regardless of the time since the primary tumor was diagnosed and treated, until proved otherwise.
authors.affiliation: Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.
authors.forename: Humayun
authors.initials: H
authors.lastname: Bashir
authors.forename: M Khalid
authors.initials: MK
authors.lastname: Nawaz
authors.forename: Mazhar A
authors.initials: MA
authors.lastname: Shah
authors.forename: Ejaz
authors.initials: E
authors.lastname: Ahmad
mesh_terms: D001706:Biopsy; D001859:Bone Neoplasms / Q000556:secondary; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008080:Liposarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D013848:Thigh; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000556:secondary* / Q000628:therapy
chemical_list: D013670:Sodium Pertechnetate Tc 99m