[The alteration of microsatellite DNA in lung cancer].
OBJECTIVE
To study the alteration of microsatellite DNA in primary lung cancer and its value of diagnosis for lung cancer.


METHODS
Five microsatellite markers on chromosome 3P13-26 have been examined in 50 primary lung cancer tissues and their normal lung tissues.


RESULTS
In fifty lung cancer, the incidence of microsatellite instability (MSI) was 52% (26/50) and the loss of heterozygosity (LOH) 38% (19/50). The positive rate of MSI in poorly differentiated lung cancer (13/17, 77%) was significantly higher than that in well, moderately differentiated (10/28, 36%). The sensitivity in the diagnosis of lung cancer was 72% by combining MSI and LOH.


CONCLUSIONS
MSI and LOH may play a certain role in the carcinogenesis and progression of lung cancer and they may be valuable molecular markers in diagnosis of lung cancer.
Chen
G
G
XI'an Medical University, Xi'an 710061.
Sun
Y
Y
Li
S
S
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged