title: Management of necrotizing pancreatitis.
abstract: Infection complicating pancreatic necrosis leads to persisting sepsis, multiple organ dysfunction syndrome and accounts for about half the deaths that occur following acute pancreatitis. Severe cases due to gallstones require urgent endoscopic sphincterotomy. Patients with pancreatic necrosis should be followed with serial contrast enhanced computed tomography (CE-CT) and if infection is suspected fine needle aspiration of the necrotic area for bacteriology (FNAB) should be undertaken. Treatment of sterile necrosis should initially be nonoperative. In the presence of infection necrosectomy is indicated. Although traditionally this has been by open surgery, minimally invasive procedures are a promising new alternative. There are many unresolved issues in the management of pancreatic necrosis. These include, the use of antibiotic prophylaxis, the precise indications for and frequency of repeat CE-CT and FNAB, and the role of enteral feeding.
authors.affiliation: Senior Lecturer, Department of Surgery, Royal Liverpool University Hospital 5th floor UCD Building, Daulby Street, Liverpool, L69 3GA, United Kingdom, UK. jpss@liverpool.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Slavin
authors.forename: P
authors.initials: P
authors.lastname: Ghaneh
authors.forename: R
authors.initials: R
authors.lastname: Sutton
authors.forename: M
authors.initials: M
authors.lastname: Hartley
authors.forename: P
authors.initials: P
authors.lastname: Rowlands
authors.forename: C
authors.initials: C
authors.lastname: Garvey
authors.forename: M
authors.initials: M
authors.lastname: Hughes
authors.forename: J
authors.initials: J
authors.lastname: Neoptolemos
mesh_terms: D006801:Humans; D019060:Minimally Invasive Surgical Procedures; D019283:Pancreatitis, Acute Necrotizing / Q000473:pathology / Q000601:surgery* / Q000628:therapy*