Characterization of cardiac muscle factor 1 sequence motifs: retinoblastoma protein binding and nuclear localization.
Cardiac muscle factor 1 (CMF1) is characterized as a protein important in cardiac and skeletal myocyte differentiation and is expressed in a developmentally regulated manner. Sequence analysis data showed that CMF1 has crucial protein-protein interaction domains, has a retinoblastoma protein-binding site which interacts with RB directly in vitro and in the embryo, has a functional nuclear localization signal and is highly homologous to other cell cycle regulatory proteins such as mitosin and centromere protein F, which suggests that CMF1 may be involved in regulating the cell cycle.
Redkar
Abhay
A
Department of Anatomy and Cell Biology, Temple University School of Medicine, 3420 North Broad Street, MRB617, Philadelphia, PA 19140, USA.
deRiel
Jon K
JK
Xu
Yong-Sheng
YS
Montgomery
Michael
M
Patwardhan
Vidya
V
Litvin
Judith
J
D000818:Animals; D030161:Avian Proteins; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D002467:Cell Nucleus / Q000378:metabolism; D002642:Chick Embryo; D002645:Chickens; D004247:DNA / Q000737:chemistry / Q000235:genetics; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D005091:Exons; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D005796:Genes / Q000235:genetics; D017403:In Situ Hybridization; D007438:Introns; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics* / Q000378:metabolism; D011485:Protein Binding; D012313:RNA / Q000235:genetics / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000378:metabolism; D017422:Sequence Analysis, DNA
D030161:Avian Proteins; D018076:DNA, Complementary; D009124:Muscle Proteins; D016160:Retinoblastoma Protein; C101539:cardiac muscle factor 1 protein, chicken; D012313:RNA; D004247:DNA