Corticosteroid-induced psychotic and mood disorders: diagnosis defined by DSM-IV and clinical pictures.
The authors investigated long-term outcome and treatment strategy of corticosteroid-induced psychotic and mood disorders as defined by DSM-IV. Review of medical records of 2,069 referral patients revealed 18 applicable patients. Their clinical characteristics, longitudinal courses, and treatments were studied. The authors identified 15 patients with mood disorder and 3 patients with psychotic disorder. Increasing doses or resumption of corticosteroids had the strongest influence on the psychiatric course. These two corticosteroid-induced psychiatric disorders may have different pathophysiological substrates closely related to patient vulnerability. Effective psychopharmacological treatment options were indicated with consideration being given to the underlying diseases.
Wada
K
K
Department of Neuropsychiatry, Okayama University Medical School, Japan. kenwada@do3.enjoy.ne.jp
Yamada
N
N
Sato
T
T
Suzuki
H
H
Miki
M
M
Lee
Y
Y
Akiyama
K
K
Kuroda
S
S
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D011605:Psychoses, Substance-Induced / Q000175:diagnosis* / Q000188:drug therapy; D020551:Pulse Therapy, Drug / Q000009:adverse effects; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D005938:Glucocorticoids