[Experimental study on effect of antagonizing platelet-activating factor and histamine of synthetic ginkgolide F in guinea-pigs].
OBJECTIVE
To investigate the antagonizing effect of synthetic Ginkgolide F (SGF) on platelet-activating factor (PAF) and histamine (HA) in guinea-pigs.


METHODS
The contraction rate of isolated lung tissue of guinea-pig and the change of pulmonary function of sensitized guinea-pig after SGF treatment were examined.


RESULTS
(1) The contraction rate of guinea-pigs' isolated trachea and lung strip induced by HA reduced from (50.97 +/- 16.00)% and (54.24 +/- 12.17)% to (21.69 +/- 3.85)% and (22.97 +/- 17.78)% after SGF treatment (P < 0.05). (2) PAF induced relative contraction of isolated guinea-pig lung strip was reduced from (89.49 +/- 16.00)% to (46.21 +/- 14.23)% in presence of SGF (P < 0.05). (3) The pulmonary function of sensitized animal had a tendency of being improved by SGF.


CONCLUSIONS
SGF can antagonize the contraction of isolated lung tissue induced by HA or PAF in vitro, and has a tendency to improve the pulmonary function of sensitized guinea-pig, therefore, it may be a promising drug in treatment of bronchial asthma.
Ni
J
J
Huashan Hospital, Shanghai Medical University, Shanghai (200040).
Dong
J
J
Wu
G
G
D000818:Animals; D001249:Asthma / Q000503:physiopathology; D005260:Female; D005343:Fibrinolytic Agents / Q000138:chemical synthesis; D020441:Ginkgo biloba / Q000737:chemistry*; D046934:Ginkgolides; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D008168:Lung / Q000503:physiopathology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009570:Nitriles / Q000138:chemical synthesis / Q000494:pharmacology*; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D014132:Trachea
D005343:Fibrinolytic Agents; D046934:Ginkgolides; D006633:Histamine Antagonists; D009570:Nitriles; D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; C451038:ginkgolide F