[Tailor-made medicine for diabetes].
Several genes are implicated to be the cause for diabetes, such as genes of PPAR gamma (peroxisome proliferator-activated receptor-gamma), adiponectin, beta 3-adrenergic receptor, etc., and their polymorphisms may have significant impact on the treatment and prevention of diabetes. Detection and analysis of such susceptibility genes will provide an enormous benefit for the future tailor-made medicine of diabetes, which include choosing the most effective treatment policy for each individual and developing novel drugs based on the genetic information that are applicable for corresponding individuals. Tailor-made medicine will be an efficient tool for treatment and prevention of lifestyle diseases, especially type 2 diabetes, along with further identification of its disease-causing genes.
Noda
Mitsuhiko
M
Institute for Diabetes Care and Research, Asahi Life Foundation.
D000085:Acetates; D052242:Adiponectin; D001565:Benzoates; D001713:Biphenyl Compounds; D002154:Calpain / Q000235:genetics; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000235:genetics* / Q000517:prevention & control; D015195:Drug Design; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D007211:Indoles; D036341:Intercellular Signaling Peptides and Proteins; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
C418363:((3-((2R)-(((2R)-3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-1H-indol-7-yloxy)acetic acid; D000085:Acetates; D052242:Adiponectin; D001565:Benzoates; D001713:Biphenyl Compounds; D007211:Indoles; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D022702:Receptors, Adrenergic, beta-3; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C438269:diazepinylbenzoic acid; D002154:Calpain; C415197:calpain 10