[Determination of S-100 beta protein in cerebrospinal fluid of patients with metastatic carcinoma to central nervous system].
OBJECTIVE
To investigate the concentration of S-100 beta protein in cerebrospinal fluid (CSF) for 25 patients with metastatic carcinoma to central nervous system (CNS), and to evaluate its clinical value.


METHODS
S-100 beta protein of CSF was measured by ELISA for 25 patients with metastatic carcinoma to CNS and 20 patients without any CNS disease (control group). The patients were divided into three categories according to severity of disease: severe group, moderate group and mild group. Meanwhile, CSF cytology was also detected.


RESULTS
The level of S-100 beta protein of all patients was higher than that of control group (P < 0.01), and severe group > moderate group (P < 0.01) > mild group (P < 0.01). The percentage of CSF lymphocyte in severe group was lower than that of mild group and control group (P < 0.05 and P < 0.01).


CONCLUSIONS
CSF S-100 beta protein level of patients with metastatic carcinoma may be related to the severity of their brain insult.
Zhao
G
G
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Yang
Y
Y
Su
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000556:secondary; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000134:cerebrospinal fluid*; D012720:Severity of Illness Index
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins