Genetic imbalances in pleomorphic xanthoastrocytoma detected by comparative genomic hybridization and literature review.
Pleomorphic xanthoastrocytoma (PXA) is a rare, low-grade astrocytic tumor found in the central nervous system. Histologically, the tumor is characterized by markedly pleomorphic and lipidized cells. Although most of the patients have a favorable prognosis, a small number of cases undergoing recurrence or progression to anaplastic astrocytoma were reported. Very few genetic studies have been performed on PXA because of its rarity and the pathogenesis of this neoplasm is largely unknown. In order to provide an overview of genetic alterations in PXA, we performed comparative genomic hybridization to identify chromosomal imbalances (DNA gains and losses) in three cases of PXA. Genetic imbalance was detected on at least one chromosome for each case. One case, which revealed multiple genetic alterations, showed a poor prognosis. DNA gain on chromosome 7 and loss on 8p were demonstrated in two of three cases, suggesting that the candidate gene(s) located on these regions may play a role in the development of PXA. Further studies are needed to identify the residing candidate genes that are involved in the tumorigenesis of PXA. In addition, the histopathological features and previous genetic studies on PXA are reviewed.
Yin
Xiao-Lu
XL
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Hui
Angela Bik-Yu
AB
Liong
Eleanore C
EC
Ding
Min
M
Chang
Alex R
AR
Ng
Ho-Keung
HK
D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D002648:Child; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D004273:DNA, Neoplasm / Q000235:genetics; D005784:Gene Amplification; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization
D004273:DNA, Neoplasm