title: [The treatment of a primary acquired melanosis of the conjunctiva with atypia by low dose of Mitomycin C 0.02 % - case report with follow up of 2 years].
abstract: BACKGROUND
  About 70 % of the melanomas of the conjunctiva develop from an primary acquired melanosis (PAM) with atypia. This is the reason why excision, radiation, cryotherapy or a combination of them are proposed for therapy. But, if the acquired melanosis is very large, serious complications will be found with that treatment.
  
  
  METHODS
  A 65-year-old woman has shown a large melanosis of the conjunctiva of her left eye. Biopsies, taken from different sites of the conjunctiva, have confirmed the diagnosis of an acquired melanosis of the conjunctiva with atypia. This has been the reason for our Mitomycin C 0.02 % therapy for one week. It has been repeated once again after half a year.
  
  
  RESULTS
  Atypia of the cells was shown in the upper cell layer of the conjunctiva after the first therapy. But after the second therapy no atypia of the cells was present within two years after the last treatment, examining several biopses.
  
  
  CONCLUSIONS
  Looking for an effective treatment without complications, a new therapy with Mitomycin C has been introduced in the last years. As it is not yet clearly known how to use Mitomycin to have maximal effectiveness with minimal complications, the reports about doses and frequency are differing a lot in the literature and are more often considerably lying over the introduced effective dose of our case. If Mitomycin is used in that low dosage and in that special application as shown, it could be a very efficient therapy with less complications.
authors.affiliation: Augenklinik rechts der Isar, Technischen Universität München.
authors.forename: M
authors.initials: M
authors.lastname: Schmidt
authors.forename: M
authors.initials: M
authors.lastname: Maier
authors.forename: T
authors.initials: T
authors.lastname: Schmidt
authors.forename: D
authors.initials: D
authors.lastname: Klaehsen
authors.forename: R L
authors.initials: RL
authors.lastname: Merté
mesh_terms: D000287:Administration, Topical; D000368:Aged; D001706:Biopsy; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003228:Conjunctiva / Q000187:drug effects / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D008548:Melanosis / Q000188:drug therapy* / Q000473:pathology; D016685:Mitomycin / Q000008:administration & dosage*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology
chemical_list: D016685:Mitomycin