Reversible infertility, pharmaceutical and spontaneous, in a male with late onset congenital adrenal hyperplasia, due to 21-hydroxylase deficiency.
The authors describe a case of a 35-year-old man with 5-year duration infertility. History, clinical examination, and laboratory tests have established the diagnosis of late-onset congenital adrenal hyperplasia, due to 21-hydroxylase deficiency. Treatment with dexamethasone resulted in improvement of sperm quality, and 4 months later a pregnancy was achieved. Two years after the patient fathered his first child, and while he had discontinued dexamethasone treatment, he succeeded at a second pregnancy. The authors conclude that (1) late-onset congenital adrenal hyperplasia presents with significant variation during the patient's lifetime; (2) glucocorticoid administration is necessary in infertile men with nonclassic form of 21-hydroxylase deficiency; and (3) in cases of male infertility of unknown origin, the patient must be scrutinized for congenital adrenal hyperplasia, especially the nonclassic form.
Kalachanis
I
I
Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece.
Rousso
D
D
Kourtis
A
A
Goutzioulis
F
F
Makedos
G
G
Panidis
D
D
D000312:Adrenal Hyperplasia, Congenital / Q000201:enzymology / Q000503:physiopathology*; D000328:Adult; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D008297:Male; D013255:Steroid 21-Hydroxylase / Q000378:metabolism*
D003907:Dexamethasone; D013255:Steroid 21-Hydroxylase