Synthesis and biological activity of the new 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid.
A series of 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid 6, were synthesized and evaluated for their antitumor activity.
Kim
Kwan-Hee
KH
Biomedical Research Institute, Kolon Central Research Park, 207-2Mabuk-Ri, Guseong-Eup, Yongin-City, Kyunggi-Do 449-797, Republic of Korea. khkim@kolon.kr
Kim
Ji-Young
JY
Lee
Keyong-Ho
KH
Noh
Moon-Jong
MJ
Kim
Youn-Chul
YC
Park
Ho-Jin
HJ
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005437:Flucytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D005437:Flucytosine