Epstein-Barr virus-associated hodgkin's disease in a patient with Wiskott-Aldrich syndrome.
Wiskott-Aldrich syndrome is a primary immunodeficiency syndrome in which the majority of malignant complications are non-Hodgkin's lymphoma. We report here a Wiskott-Aldrich syndrome patient who developed Epstein-Barr virus-positive Hodgkin's disease in the bilateral pulmonary hilar lymph nodes. The treatment was successful as the patient achieved a complete response and event-free survival for more than 4 y.


CONCLUSIONS
This case is very rare, but highly suggestive of the immune-mediated mechanisms in the pathogenesis of Epstein-Barr virus-associated Hodgkin's disease in an immunodeficiency patient.
Sasahara
Y
Y
Department of Pediatric Oncology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan.
Fujie
H
H
Kumaki
S
S
Ohashi
Y
Y
Minegishi
M
M
Tsuchiya
S
S
D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D014763:Viral Matrix Proteins; D014923:Wiskott-Aldrich Syndrome / Q000821:virology*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins