[Experimental study of analgesic effect of combined Radix Aconiti and Radix Stephaniae Tetrandrae].
OBJECTIVE
To explore the changes of analgesic effect of combined Radix Aconiti (RA) and Radix Stephaniae Tetrandrae (RST).


METHODS
Randomly divide the rabbits and mice into following groups: the blank control group, the positive control group, the RA group, the RST group, the combined RA:RST(1:1) group, the combined RA:RST(1:2) group. Then, using chemical, heat and electrical stimuli, four kinds of pain models were produced, which were to observe the changes of pain threshold of mice before and after using combined RA and RST therapy.


RESULTS
Remarkable analgesic effect was obtained in the positive control group and all the groups treated with these two herbs within 3 hours (P < 0.01), and the effect was more obvious in the combined RA-RST groups and the RA group. The analgesic effect of the positive control group, the RST and the RA group weakened gradually 3 hours later, and at the 24th hour, the effect disappeared in the positive control group and the RST group but it is still remarkable in the combined RA-RST group, which has a significant difference from the positive control group and the groups treated with one single herb (RA or RST).


CONCLUSIONS
The analgesic effect of the combined RA-RST is superior to the RA and the RST used alone.
Li
X
X
Shandong University of TCM, Jinan (250014).
Zhang
S
S
Qin
L
L
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects*; D011817:Rabbits; D011897:Random Allocation
D018712:Analgesics, Non-Narcotic; D004365:Drugs, Chinese Herbal