EGF receptor signalling: roles of star and rhomboid revealed.
Recent studies have clarified how the active form of the Drosophila EGF receptor ligand Spitz is produced: Star chaperones Spitz in the ER and mediates its transport to the Golgi, where the intramembrane serine protease Rhomboid cleaves the Spitz proprotein to initiate secretion.
Klämbt
Christian
C
Institut für Neuro- und Verhaltensbiologie, Universität Münster, 48149, Münster, Germany.
D000818:Animals; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology*; D008954:Models, Biological; D021381:Protein Transport; D012697:Serine Endopeptidases / Q000502:physiology; D015398:Signal Transduction
D029721:Drosophila Proteins; D008565:Membrane Proteins; C081481:Rho protein, Drosophila; C415248:S protein, Drosophila; C472498:Stet protein, Drosophila; C076026:spi protein, Drosophila; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D012697:Serine Endopeptidases