title: [Alpha-1-antitrypsin deficiency. An indication for pediatric liver transplantation].
abstract: Alpha-1-antitrypsin deficiency is the most common inborn error of metabolism leading to liver transplantation, and the second cause of liver transplantation in children after biliary atresia. The authors report the case of a 6-year-old girl, who was suffering from end-stage liver disease secondary to alpha-1-antitrypsin deficiency. She was successfully treated by whole liver transplantation, the hepatic graft coming from a 3-year-old donor. Three months later she went back to school. The authors discuss the pathogenesis and the natural history of this frequent cause of liver transplantation in children.
authors.affiliation: Service de Chirurgie Abdominale et Transplantation, Université de Liège.
authors.forename: A
authors.initials: A
authors.lastname: De Roover
authors.forename: O
authors.initials: O
authors.lastname: Detry
authors.forename: P
authors.initials: P
authors.lastname: Honoré
authors.forename: K
authors.initials: K
authors.lastname: Delbecque
authors.forename: L
authors.initials: L
authors.lastname: de Leval
authors.forename: J
authors.initials: J
authors.lastname: Delwaide
authors.forename: J
authors.initials: J
authors.lastname: Joris
authors.forename: J L
authors.initials: JL
authors.lastname: Canivet
authors.forename: P
authors.initials: P
authors.lastname: Damas
authors.forename: J
authors.initials: J
authors.lastname: Boniver
authors.forename: M
authors.initials: M
authors.lastname: Lamy
authors.forename: M
authors.initials: M
authors.lastname: Meurisse
authors.forename: N
authors.initials: N
authors.lastname: Jacquet
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D016031:Liver Transplantation; D016896:Treatment Outcome; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications*