title: Cytotoxic alkaloids from Houttuynia cordata.
abstract: Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
authors.affiliation: Korea Research Institute of Chemical Technology, Taejeon. kims@plaza.snu.ac.kr
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.forename: S Y
authors.initials: SY
authors.lastname: Ryu
authors.forename: J
authors.initials: J
authors.lastname: No
authors.forename: S U
authors.initials: SU
authors.lastname: Choi
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification* / Q000494:pharmacology; D052859:Houttuynia; D006801:Humans; D026121:Indole Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D007546:Isoquinolines / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; C442781:Houttuynia cordata extract; D026121:Indole Alkaloids; D007546:Isoquinolines; C457228:aristolactam A; C457227:piperolactam A; C064674:aristololactam BII; C457230:cepharadione B; C457229:norcepharadione B; C457226:splendidine