title: Neutrophil alloantigens.
abstract: Antibodies to neutrophil antigens can cause neonatal alloimmune neutropenia, autoimmune neutropenia, febrile transfusion reactions, and transfusion-related acute lung injury. Several neutrophil antigen systems have been described serologically, but only the human neutrophil antigen-1 (HNA-1) or NA and HNA-2 or NB systems have been well characterized biochemically and molecularly. HNA-1 antigens are located on FcgammaRIIIb, CD16. HNA-2 antigens are located on 58- to 64-Kd glycoprotein, CD177, and are encoded by a gene on chromosome 19 that belongs to the Ly-6 family. The function of the CD177 is not known, but the CD177 gene is highly homologous to a gene overexpressed in neutrophils from patients with polycythemia rubra vera called PRV-1. New polymorphisms in these antigen systems are still being described, but the complete understanding of these neutrophil antigen systems has been slow because of the complexity of these genes.
authors.affiliation: Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892-1184, USA.
authors.forename: David
authors.initials: D
authors.lastname: Stroncek
mesh_terms: D019943:Amino Acid Substitution; D000911:Antibodies, Monoclonal / Q000276:immunology; D018821:CD18 Antigens / Q000235:genetics / Q000276:immunology; D005544:Forecasting; D058851:GPI-Linked Proteins; D015870:Gene Expression; D014644:Genetic Variation; D006098:Granulocytes; D006801:Humans; D007519:Isoantigens / Q000145:classification / Q000235:genetics / Q000276:immunology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology; D020125:Mutation, Missense; D009503:Neutropenia / Q000209:etiology / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface; D017452:Receptors, IgG / Q000172:deficiency / Q000276:immunology; D009626:Terminology as Topic
chemical_list: C451326:5a antigen; C451327:5b antigen; D000911:Antibodies, Monoclonal; C407242:CD177 protein, human; D018821:CD18 Antigens; D058851:GPI-Linked Proteins; D007519:Isoantigens; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D017452:Receptors, IgG; C067704:neutrophil-specific antigen NA1, human; C072753:neutrophil-specific antigen NA2; C104384:neutrophil-specific antigen SH; C451328:ond(a) antigen