title: Topical anti-inflammatory activity of Thymus willdenowii.
abstract: The topical anti-inflammatory activity of Thymus willdenowii Boiss (Labiatae) leaves, a herbal drug used in Moroccan folk medicine, has been studied using the croton oil ear test in mice. A bioassay-oriented fractionation procedure showed that the activity concentrates in the chloroform extract, which has a potency similar to that of indometacin, the non-steroidal anti-inflammatory drug used as reference (ID50 (dose giving 50% oedema inhibition) = 83 microg cm(-2) and 93 microg cm(-2), respectively). The main compounds responsible for the anti-inflammatory activity of T. willdenowii are ursolic acid and oleanolic acid. The flavonoids luteolin-3'-O-glucuronide and eriodictyol-7-O-glucoside were found for the first time in the genus Thymus.
authors.affiliation: Faculté de Médecine et Pharmacie, Université Mohammed V, Rabat, Morocco.
authors.forename: H
authors.initials: H
authors.lastname: Ismaili
authors.forename: S
authors.initials: S
authors.lastname: Tortora
authors.forename: S
authors.initials: S
authors.lastname: Sosa
authors.forename: S
authors.initials: S
authors.lastname: Fkih-Tetouani
authors.forename: A
authors.initials: A
authors.lastname: Ilidrissi
authors.forename: R
authors.initials: R
authors.lastname: Della Loggia
authors.forename: A
authors.initials: A
authors.lastname: Tubaro
authors.forename: R
authors.initials: R
authors.lastname: Aquino
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification*; D005419:Flavonoids / Q000302:isolation & purification; D019686:Lamiaceae / Q000737:chemistry*; D009828:Oleanolic Acid / Q000302:isolation & purification*; D010936:Plant Extracts / Q000032:analysis; D014315:Triterpenes / Q000302:isolation & purification*; D000097245:Ursolic Acid
chemical_list: D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D009828:Oleanolic Acid; D010936:Plant Extracts; D014315:Triterpenes; D000097245:Ursolic Acid