[Pseudocholinesterase (ChE)].
In order to establish a recommendation for the measurement of serum pseudocholinesterase (ChE), the Japan Society of Clinical Chemistry has been deribesating for several years. However, they have not yet reached a conclusion. A decrease in serum ChE is clinically meaningful and serum ChE sensitively reflects a degree of chronic diffuse liver damage. ChE isozyme is analyzed not for the estimation of origin of the enzyme, but for the evaluation of familial ChE variants. Electrophoresis or blocking by dibucaine or fluoride are employed for the detection of ChE isozyme. Familial ChE variants are related to succinylcholine apnea in cases of very low serum ChE activities.
Yanai
M
M
Department of Clinical Pathology, Nihon University School of Medicine.
Hoshino
T
T
D015415:Biomarkers / Q000097:blood; D002091:Butyrylcholinesterase / Q000097:blood* / Q000172:deficiency / Q000235:genetics; D002100:Cachexia / Q000175:diagnosis; D004796:Clinical Enzyme Tests / Q000379:methods; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008107:Liver Diseases / Q000175:diagnosis; D009154:Mutation; D009404:Nephrotic Syndrome / Q000175:diagnosis
D015415:Biomarkers; D007527:Isoenzymes; D002091:Butyrylcholinesterase