[Pharmacotherapy for the treatment of Alzheimer's disease--the present state and the development in the future].
We can observe progressions through stages of symptoms, which are memory and cognitive loss, functional impairment and behavioral disinhibition or apathy, in patients with Alzheimer's disease (AD). Medications of acethylcholine esterase inhibitors such as donepezil offer hope for improving or stabilizing the symptoms of AD temporarily. We desire that new pharmacological interventions up the stream of amyloid cascade theory of AD will be established. Many medical challenges and researches will be tried to find the cause of AD and eternal disease stabilization, or even prevention, may be possible in the future.
Yamaguchi
Noboru
N
Department of Neuropsychiatry, St. Marianna University School of Medicine.
Okada
Nagako
N
Sugiyama
Tsuneyuki
T
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000209:etiology; D000682:Amyloid / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D002800:Cholinesterase Inhibitors; D015195:Drug Design; D006801:Humans; D009154:Mutation
D000682:Amyloid; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D002800:Cholinesterase Inhibitors