[Study of heart valve function on obese patients treated with sibutramine].
BACKGROUND
Some anorectic drugs have been related with he development of heart valve lesions. Sibutramine is a new anorectic drug used for the treatment of obesity. Although data reported to date suggest that sibutramine does not induce heart valve lesions, there are no published reports performing longitudinal echocardiographic studies before and after treatment with sibutramine.


METHODS
Consecutive series of 16 obese patients who underwent Doppler-echocardiography before and after treatment with sibutramine.


RESULTS
After 6 months of treatment, at 10 mg/day dose, sibutramine does noe appear to induce heart valve lesions.


CONCLUSIONS
Sibutramine does not induce heart valve lesions when it is used in short-term treatment courses.
Pereira
José Luis
JL
Unidad de Nutrición Clínica. Servicios de Endocrinología. Hospital Universitario Virgen del Rocío. Sevilla. Spain.
López-Pardo
Francisco
F
Parejo
Juana
J
Astorga
Ricardo
R
Rodríguez-Puras
María José
MJ
García-Luna
Pedro Pablo
PP
D000328:Adult; D001067:Appetite Depressants / Q000009:adverse effects*; D003503:Cyclobutanes / Q000009:adverse effects*; D005260:Female; D006349:Heart Valve Diseases / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D011446:Prospective Studies
D001067:Appetite Depressants; D003503:Cyclobutanes; C058254:sibutramine