A genome-wide scan for obesity in African-Americans.
A genome-wide scan using 387 short tandem repeat markers was conducted for obesity among 618 black individuals from 202 families residing in a suburb of Chicago. Evidence for linkage was evaluated with BMI and percent body fat (PBF) using a variance component analysis approach. Suggestive evidence for linkage was found for BMI on chromosome 5 (logarithm of odds [LOD] score = 1.9) and PBF on chromosome 6 (LOD score = 2.7). One additional region on chromosome 3 was linked to these phenotypes at a lower level of significance (LOD score = 1.8 and 0.95 for BMI and PBF, respectively); the linked marker on this chromosome lies in the same region implicated as harboring obesity genes in a previous study of a white population. The replication of linkage evidence using different ethnic groups reinforces the potential significance of this latter candidate region.
Zhu
Xiaofeng
X
Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA. xzhu1@luc.edu
Cooper
Richard S
RS
Luke
Amy
A
Chen
Guanjie
G
Wu
Xiaodong
X
Kan
Donghui
D
Chakravarti
Aravinda
A
Weder
Alan
A
D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D001741:Black or African American; D044383:Black People / Q000235:genetics*; D015992:Body Mass Index; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D016678:Genome; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000473:pathology; D020080:Tandem Repeat Sequences