[Abnormal P3 latency in obstructive sleep apnea syndrome, but normal in snore].
OBJECTIVE
To evaluate the P3 wave (latency, amplitude) in snorers and patients with obstructive sleep apnea syndrome (OSAS) and investigate the possible mechanism.


METHODS
Three groups, OSAS patient group (n = 21), snorer group (n = 21) and control group (n = 21), were administered polysomnography (PSG), auditory evoked event-related potential (P3) and clinic memory test. The results were analyzed using GLM analysis and Post Hoc test.


RESULTS
The auditory P3 latency in OSAS group was 363 ms +/- 22 ms (Fz), 369 ms +/- 28 ms (Cz), in snorer group 336 ms +/- 31 ms (Fz), 340 ms +/- 32 ms (Cz), and in control group 341 ms +/- 29 ms (Fz), 338 ms +/- 30 ms (Cz). There were significant differences between OSAS group and snorer group, as well as control group (P < 0.05). No significant difference was seen between snorer group and control group. Memory quotient (MQ) was reduced in snoren group as compared with control group.


CONCLUSIONS
Abnormal auditory P3 latency indicates the cognitive dysfunction in OSAS patients. Nocturnal hypoxaemia may play an important role.
Peng
B
B
Department of Neurology, Peking Union Medical University Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Li
S
S
Huang
X
X
D000328:Adult; D000367:Age Factors; D001784:Blood Gas Analysis; D004522:Educational Status; D004594:Electrophysiology; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology; D017286:Polysomnography / Q000379:methods; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D012913:Snoring / Q000503:physiopathology*