title: The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus.
abstract: Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.
authors.affiliation: Hokkaido University Graduate School of Medicine, Division of Cancer Medicine, Cancer Medicine, Surgical Oncology, N-14, W-5, Sapporo 060-8648, Japan. nakakubo@med.hokudai.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nakakubo
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hida
authors.forename: Masaki
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hashida
authors.forename: Taro
authors.initials: T
authors.lastname: Oshikiri
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kato
authors.forename: Masato
authors.initials: M
authors.lastname: Suzuoki
authors.forename: Kei
authors.initials: K
authors.lastname: Hiraoka
authors.forename: Tomoo
authors.initials: T
authors.lastname: Ito
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Morikawa
authors.forename: Shunichi
authors.initials: S
authors.lastname: Okushiba
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kondo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Katoh
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000378:metabolism*; D000954:Antigens, Surface / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; C120762:EBAG9 protein, human