[Polyarteritis nodosa and hepatitis B infection treated with lamivudine].
A 36-year-old man was diagnosed with polyarteritis nodosa (PAN). He presented with weight loss, hypertension, and mono-neuritis. Pneumoperitoneum and septicaemia developed and laparotomy revealed necrosis of a segment of the ileum. The patient was HBsAg/HBeAg and HBV DNA positive. Liver biopsy showed active cirrhosis. The PAN symptoms remitted upon treatment with prednisolone and lamivudine. Seroconversion from HBeAg to anti-HBe occurred six months later. One year after the end of treatment, the patient was still HBeAg and HBV DNA negative, with normal liver enzymes and no symptoms of PAN.
Münster
Tine
T
Infektionsmedicinsk afdeling, H:S Hvidovre Hospital, klinisk forskningsenhed.
Weis
Nina M
NM
Krogsgaard
Kim
K
D000328:Adult; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D019694:Hepatitis B, Chronic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage*; D008297:Male; D010488:Polyarteritis Nodosa / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage*
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine