title: Abietic acid inhibits lipoxygenase activity.
abstract: In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.
authors.affiliation: Hacettepe University, Faculty of Medicine, Department of Biochemistry, 06100 Ankara, Turkey.
authors.forename: N Nuray
authors.initials: NN
authors.lastname: Ulusu
authors.forename: Dilek
authors.initials: D
authors.lastname: Ercil
authors.forename: M Koray
authors.initials: MK
authors.lastname: Sakar
authors.forename: E Ferhan
authors.initials: EF
authors.lastname: Tezcan
mesh_terms: D028202:Abies; D045784:Abietanes; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D019787:Linoleic Acid / Q000494:pharmacology; D008084:Lipoxygenase / Q000378:metabolism*; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D045784:Abietanes; D004224:Diterpenes; D004791:Enzyme Inhibitors; D010616:Phenanthrenes; D010936:Plant Extracts; D019787:Linoleic Acid; D008084:Lipoxygenase; C023710:abietic acid