title: Work-up strategies for high-throughput solution synthesis.
abstract: The key bottleneck in parallel synthesis has, in truth, always been the isolation and purification of the reaction products, rather than carrying out the reactions themselves. Solution-phase chemistry for parallel synthesis has recently been re-emphasized and has stimulated the development of a wide-range of practical tools for efficient high-throughput work-up, which are gaining increasing acceptance in medicinal chemistry groups.
authors.affiliation: Takeda Chemical Industries, Medicinal Chemistry Research, Laboratories I, Pharmaceutical Research Division 17-85 Juso-Honmachi 2-ChomeYodogawa-Ku, Osaka, 532-8686, Japan.
authors.forename: David
authors.initials: D
authors.lastname: Cork
authors.forename: Nick
authors.initials: N
authors.lastname: Hird
mesh_terms: D001331:Automation; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000458:organization & administration; D005374:Filtration; D012117:Resins, Synthetic / Q000737:chemistry; D012996:Solutions
chemical_list: D012117:Resins, Synthetic; D012996:Solutions