[A multianalysis study on clinicopathologic factors related to lymph node metastasis in gastric cancer].
OBJECTIVE
To study the function of CD44v6, MMP-9, TIMP-1 and cNOS in the invasion and metastasis of gastric cancer and their value in estimating early lymph node metastasis.


METHODS
Logistic stepwise regression model was used to analyze the influence of ten clinicopathological factors on the lymph node metastasis in 119 cases of gastric cancer.


RESULTS
Using the established equation to estimate lymph node metastasis, the stronger the CD44v6 expression, the higher the frequency of lymph node metastasis; the frequency of lymph node metastasis was the highest in patients with positive MMP-9 and negative TIMP-1 expression. However, the frequency was the lowest in those with negative MMP-9 and positive TIMP-1 expression and that of positive expression in hemangio-lymphangio-endothelial cells of gastric cancer was relatively high.


CONCLUSIONS
The intensity of CD44v6 expression, the imbalance between MMP-9 and TIMP-1 expressions and cNOS mRNA expression in the endothelial cells were highly useful for the preoperative diagnosis of lymph node metastasis in gastric cancer patients.
Zhang
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First Hospital, Fujian Medical University, Fuzhou 350005, China.
Li
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Lin
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015870:Gene Expression; D006023:Glycoproteins / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis / Q000502:physiology*; D017403:In Situ Hybridization; D016015:Logistic Models; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis / Q000502:physiology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000502:physiology*; D052250:Nitric Oxide Synthase Type III; D012333:RNA, Messenger; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000096:biosynthesis / Q000502:physiology*
C112697:CD44v6 antigen; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D012333:RNA, Messenger; D019715:Tissue Inhibitor of Metalloproteinase-1; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; D020780:Matrix Metalloproteinase 9