Telomeric associations of chromosomes in patients with esophageal squamous cell carcinomas.
AIM:To investigate the role of telomeric association in the development of esophageal cancer.METHODS:Using chromosome R banding technique,telomeric association of chromosome in peripheral blood lymphocytes from 16 untreated patients with esophageal squamous cell carcinoma were observed and 16 healthy adults served as controls.RESULTS:The teloemeric association frequencies of cell and chromosomes were significantly higher than those of controls(X(2) = 9.56,P <0.01), but its distribution on the chromosome showed no significant difference (X(2) =1.01, P >0.05) between the two groups.CONCLUSION:Chromosomal instability can be initiated by telomeric associations, and sequential chromosome analysis can aid the understanding of the tumor occurrence and progression.
Xiao
Lin
L
Zhou
Hong-Yuan
HY
Luo
Zhong-Cheng
ZC
Liu
Jun
J