title: An attempt directed toward enhanced shape selectivity in reversed-phase liquid chromatography: preparation of the dodecylaminated beta-cyclodextrin-bonded phase.
abstract: With the aim of preparing a stationary phase with a high shape-recognition ability for liquid chromatography, a new bonded phase was synthesized by coupling multiply dodecylamino-substituted beta-cyclodextrin (beta-CD) to 3-glycidoxypropyl-derivatized silica gel. The stationary phase prepared in this way was expected to have increased shape selectivity compared with that of conventional reversed-phase materials, due to solute interactions with the alkyl chain piles built up on the beta-CDs bonded to silica. The separation characteristics of the bonded phase were investigated using polycyclic aromatic hydrocarbons (PAHs) with different molecular shapes and compared with those of monomeric ODS and native beta-cyclodextrin-bonded phases. The newly developed stationary phase was found to be highly selective for PAHs.
authors.affiliation: Department of Chemistry, Hamamatsu University School of Medicine, Japan. fujimoto@hama-med.ac.jp
authors.forename: Chuzo
authors.initials: C
authors.lastname: Fujimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Maekawa
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Murao
authors.forename: Kiyokatsu
authors.initials: K
authors.lastname: Jinno
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeichi
mesh_terms: D000588:Amines; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003505:Cyclodextrins / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000302:isolation & purification*; D047392:beta-Cyclodextrins
chemical_list: D000588:Amines; D003505:Cyclodextrins; D011084:Polycyclic Aromatic Hydrocarbons; D047392:beta-Cyclodextrins; C031215:betadex