[Clinical and experimental study on Shuanghua aerosol in treating infantile upper respiratory tract infection].
OBJECTIVE
To study the effect and mechanism of Shuanghua aerosol (SHA) in treating infantile upper respiratory tract infection (IURTI).


METHODS
In the clinical study, 276 cases of IURTI were randomly divided into two groups. The treated group was treated with SHA and the control group was treated with Shuanghuanglian aerosol (SHLA). In the experimental study, the effect of SHA on anti-inflammatory and anti-viral were observed.


RESULTS
The clinical total effective rate of SHA was 99.03% and its cure rate 65.38%, while those of the SHLA was 94.11% and 44.12% respectively, significant difference was shown between the two groups (P < 0.01). Experimental study showed that SHA could inhibit the xylol induced ear swelling and the egg white induced paw swelling in mice obviously, suppress the proliferation of influenza virus in rat's lung.


CONCLUSIONS
SHA has obvious anti-inflammatory and anti-viral effect, and has good curative effect in treating IURTI.
Ma
B
B
First Affiliated Hospital of Henan College of TCM, Zhengzhou (450000).
Duan
X
X
Wang
Z
Z
D000280:Administration, Inhalation; D000293:Adolescent; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D000998:Antiviral Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D012141:Respiratory Tract Infections / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal