[Using testicular sperm to provide fertility for azoospermia men].
OBJECTIVE
To investigate the effect of intracytoplasmic sperm injection (ICSI) on providing fertility for obstructive and non-obstructive azoospermia men after testicular spermatozoa extraction (TESE).


METHODS
TESE and ICSI were performed at the day of ovum pick up.


RESULTS
TESE and ICSI were performed successfully for 11 cycles in obstructive azoospermia men; The fertilization rate (FR) and clinical pregnancy rate (PR) were 67.0% (69/103) and 18.2% (2/11), respectively. In non-obstructive azoospermia group (21 cycles) including 3 cases of severe oligozoospermia, only in 13 cycles could sperm be found to perform ICSI, with the FR of 59.0% (72/112); 11 cycles had embryo transfer, and the average embryo number for transfer was 2.8. Three cases got clinical pregnancy. In 8 cycles, TESE were failed. The first case delivered a normal boy in June 1998.


CONCLUSIONS
Using testicular sperm for ICSI is relatively difficult, but it is a practical method to provide fertility for obstructive or non-obstructive azoospermia men. Its efficacy, however, is needed to be improved.
Li
M
M
Reproductive Center, Department of Obstetrics & Gynecology, First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, China.
Zhuang
G
G
Zhou
C
C
D005260:Female; D005298:Fertility / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009845:Oligospermia / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000637:transplantation*; D013737:Testis / Q000166:cytology; D014182:Transplantation, Autologous; D016896:Treatment Outcome