Successful management and perinatal outcome of pregnancy complicated with myelodysplastic syndrome.
Pregnancy complicated with myelodysplastic syndrome (MDS) is rare and case management is controversial. We report six cases of MDS that were successfully managed during pregnancy including uneventful transvaginal delivery and satisfactory postpartum clinical prognosis. Two patients with MDS who became pregnant twice had normal uneventful deliveries showing no deterioration of MDS. Our findings suggest that pregnancy should be allowed to full-term in MDS patients, especially those of the refractory anemia type, but strict management should be provided before, during and after pregnancy. Pancytopenia might develop during pregnancy but the likelihood of transformation of MDS to leukemia due to pregnancy is remote.
Ikeda
Yuichiro
Y
Departments of Obstetrics and Gynecology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. ikebon@net.nagasaki-u.ac.jp
Masuzaki
Hideaki
H
Nakayama
Daisuke
D
Maeda
Takahiro
T
Newaz Khan
Khaleque
K
Okita
Yuko
Y
Doi
Emiko
E
Tomonaga
Masao
M
Ishimaru
Tadayuki
T
D000328:Adult; D000740:Anemia / Q000235:genetics / Q000473:pathology / Q000628:therapy; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics / Q000628:therapy; D001853:Bone Marrow / Q000473:pathology; D036861:Delivery, Obstetric; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology / Q000628:therapy*; D011256:Pregnancy Outcome; D011379:Prognosis; D013997:Time Factors