(-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions.
Jin
Guo-Zhang
GZ
Institute of Shanghai of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, P.R. China. gzjin@mail.shcnc.ac.cn
Zhu
Zi-Tao
ZT
Fu
Yu
Y
D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001479:Basal Ganglia / Q000378:metabolism; D001599:Berberine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D065127:Dopamine D2 Receptor Antagonists; D006801:Humans; D009474:Neurons / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism; D017447:Receptors, Dopamine D1 / Q000819:agonists*; D012559:Schizophrenia / Q000188:drug therapy; D009435:Synaptic Transmission; D017557:Ventral Tegmental Area / Q000378:metabolism
D014150:Antipsychotic Agents; D015259:Dopamine Agents; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D001599:Berberine; C010513:stepholidine; D004298:Dopamine