Antenatal corticosteroids in women with preterm premature rupture of the membranes.
The authors believe that the literature provides sufficient evidence that antenatal corticosteroid administration is beneficial and safe even in conditions of ruptured membranes. The evidence by now is remarkably robust and one can be reasonably confident regarding the benefits of antenatal corticosteroids in the setting of ruptured membranes. As recently stated by a group of investigators from New Zealand, including Liggins, the originator of this historical medical intervention (antepartum corticosteroids), the safety and efficacy of corticosteroids in conditions of ruptured membranes is beyond any doubt. It is time to accept this reality and to move on to other unresolved issues, like the optimal dose and corticosteroid preparation, the optimal timing of treatment, or the optimal exposure interval.
Vidaeff
A C
AC
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas-Houston Medical School, Houston, Texas, USA. alex.c.vidaeff@uth.tmc.edu
Ramin
S M
SM
Gilstrap
L C
LC
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D004334:Drug Administration Schedule; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000517:prevention & control*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care
D000305:Adrenal Cortex Hormones