title: New data and tools for integrating discrete and continuous population modeling strategies.
abstract: Realistic population models have interactions between individuals. Such interactions cause populations to behave as systems with nonlinear dynamics. Much population data analysis is done using linear models assuming no interactions between individuals. Such analyses miss strong influences on population behavior and can lead to serious errors--especially for infectious diseases. To promote more effective population system analyses, we present a flexible and intuitive modeling framework for infection transmission systems. This framework will help population scientists gain insight into population dynamics, develop theory about population processes, better analyze and interpret population data, design more powerful and informative studies, and better inform policy decisions. Our framework uses a hierarchy of infection transmission system models. Four levels are presented here: deterministic compartmental models using ordinary differential equations (DE); stochastic compartmental (SC) models that relax assumptions about population size and include stochastic effects; individual event history models (IEH) that relax the SC compartmental structure assumptions by allowing each individual to be unique. IEH models also track each individual's history, and thus, allow the simulation of field studies. Finally, dynamic network (DNW) models relax the assumption of the previous models that contacts between individuals are instantaneous events that do not affect subsequent contacts. Eventually it should be possible to transit between these model forms at the click of a mouse. An example is presented dealing with Cryptosporidium. It illustrates how transiting model forms helps assess water contamination effects, evaluate control options, and design studies of infection transmission systems using nucleotide sequences of infectious agents.
authors.affiliation: Department of Epidemiology and Center for the Study of Complex Systems, University of Michigan, Ann Arbor 48109, USA. jkoopman@umich.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Koopman
authors.forename: G
authors.initials: G
authors.lastname: Jacquez
authors.forename: S E
authors.initials: SE
authors.lastname: Chick
mesh_terms: D003627:Data Interpretation, Statistical; D004196:Disease Outbreaks; D004813:Epidemiology; D006801:Humans; D015994:Incidence; D008962:Models, Theoretical; D011157:Population Dynamics