[Adrenomedullin and hypoxia-induced pulmonary hypertension].
OBJECTIVE
To study adrenomedullin (AM) in rat and human lung during hypoxia-induced pulmonary hypertension.


METHODS
Normobaric hypoxic pulmonary hypertension animal model was adopted, pulmonary artery pressure and RVdp/dt were measured. The changes of AM contents in blood and bronchoalveolar lavage fluid were studied. The plasma levels of AM in patients with pulmonary hypertension were measured.


RESULTS
During hypoxia, pulmonary artery pressure, RVdp/dt, AM contents in blood and bronchoalveolar lavage fluid in rats increased. Plasma levels of AM were significantly higher in patients with pulmonary hypertension than in the control subjects.


CONCLUSIONS
AM may play an important role in developing hypoxic pulmonary hypertension in rats and human. The increase of AM level is in proportion to the extent of pulmonary hypertension.
Yu
Z
Z
Department of Respiratory Medicine, Beijing General Hospital of PLA, Beijing 100700, China.
Kong
J
J
Wang
S
S
D053607:Adrenomedullin; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D000860:Hypoxia / Q000150:complications; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood / Q000378:metabolism*; D011651:Pulmonary Artery / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
D010455:Peptides; D053607:Adrenomedullin