Hippocampal complex and retrieval of recent and very remote autobiographical memories: evidence from functional magnetic resonance imaging in neurologically intact people.
It has been argued that the role of the hippocampus in memory is time-limited: during a period of memory consolidation, other brain regions such as the neocortex are said to acquire the ability to support memory retention and retrieval on their own. An alternative view is that retention and retrieval of memory for autobiographical episodes depend on the hippocampal complex, regardless of the age of the memory. We examined the participation of the hippocampal complex in a functional magnetic resonance imaging (fMRI) study in which participants were asked to recollect autobiographical events that occurred either within the last 4 years or more than 20 years ago. We found equivalent levels of hippocampal activation in both conditions in all participants (N = 10). In addition, activation in neocortical regions did not differ as a function of the age of the memory, even though most of the recent memories recalled were less than 2 years old and the remote memories more than 35 years old. The results support the notion that the hippocampal complex participates in retention and recovery of even very old autobiographical memories, and place boundary conditions on theories of memory consolidation.
Ryan
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Cognition Laboratory, Department of Psychology, University of Arizona, Tucson 85721-0068, USA. ryant@u.arizona.edu
Nadel
L
L
Keil
K
K
Putnam
K
K
Schnyer
D
D
Trouard
T
T
Moscovitch
M
M
D001325:Autobiographies as Topic; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D019579:Neocortex / Q000502:physiology; D012016:Reference Values; D013997:Time Factors