title: [Study of heart valve function on obese patients treated with sibutramine].
abstract: BACKGROUND
  Some anorectic drugs have been related with he development of heart valve lesions. Sibutramine is a new anorectic drug used for the treatment of obesity. Although data reported to date suggest that sibutramine does not induce heart valve lesions, there are no published reports performing longitudinal echocardiographic studies before and after treatment with sibutramine.
  
  
  METHODS
  Consecutive series of 16 obese patients who underwent Doppler-echocardiography before and after treatment with sibutramine.
  
  
  RESULTS
  After 6 months of treatment, at 10 mg/day dose, sibutramine does noe appear to induce heart valve lesions.
  
  
  CONCLUSIONS
  Sibutramine does not induce heart valve lesions when it is used in short-term treatment courses.
authors.affiliation: Unidad de Nutrición Clínica. Servicios de Endocrinología. Hospital Universitario Virgen del Rocío. Sevilla. Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Pereira
authors.forename: Francisco
authors.initials: F
authors.lastname: López-Pardo
authors.forename: Juana
authors.initials: J
authors.lastname: Parejo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Astorga
authors.forename: María José
authors.initials: MJ
authors.lastname: Rodríguez-Puras
authors.forename: Pedro Pablo
authors.initials: PP
authors.lastname: García-Luna
mesh_terms: D000328:Adult; D001067:Appetite Depressants / Q000009:adverse effects*; D003503:Cyclobutanes / Q000009:adverse effects*; D005260:Female; D006349:Heart Valve Diseases / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; C058254:sibutramine