Changes in respiratory function following the intramuscular administration of etorphine to boer goats (Capra hircus).
The physiological effects on respiratory function of etorphine (M99, Logos Agvet) (30 microg/kg) administered intramuscularly were determined in boer goats. The goats were habituated to the experimental procedures so that respiratory function could be determined while the animals stood quietly at rest. This enabled the physiological changes induced by etorphine to be measured and compared with those obtained before administration of the immobilising drug. The effectiveness of diprenorphine (M5050, Logos Agvet) (3 mg/l mg etorphine) as an antagonist of the physiological changes induced by the etorphine treatment was also determined. Etorphine depressed respiratory function, which resulted in a decrease in PaO2 and an increase in PaCO2. These changes were limited and occurred as a result of decreases in respiratory minute volume and alveolar minute ventilation caused by a decrease in respiratory rate. The physiological shunt fraction did not change significantly but there was a significant decrease in percentage physiological dead space ventilation. It was not possible to determine how effectively diprenorphine reversed the respiratory effects due to etorphine.
Buss
P E
PE
Department of Companion Animal Surgery, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
Meltzer
D G
DG
D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D002245:Carbon Dioxide / Q000097:blood; D004174:Diprenorphine / Q000008:administration & dosage / Q000494:pharmacology; D005048:Etorphine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D006041:Goats / Q000502:physiology*; D007103:Immobilization; D007273:Injections, Intramuscular / Q000662:veterinary; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D009294:Narcotics / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D012119:Respiration / Q000187:drug effects*; D012126:Respiratory Dead Space; D012129:Respiratory Function Tests / Q000662:veterinary; D013990:Tidal Volume / Q000187:drug effects; D013997:Time Factors
D009292:Narcotic Antagonists; D009294:Narcotics; D002245:Carbon Dioxide; D004174:Diprenorphine; D005048:Etorphine