Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model.
To evaluate the performance of an artificial liver, we created a recoverable hepatic failure rat model. This involves a 30-60 minute warm ischemia, via clamping, of one-third of the liver with a partial (two-thirds) hepatectomy. Variations on this method provide for the possibility of several modes of hepatic failure. Survival time of the rats was prolonged (35%) by applying our hybrid artificial liver. However, the extracorporeal circulation is a considerable burden to the rat. Therefore, we need to apply the hybrid artificial liver intermittently and repeatedly.
Ijima
H
H
Department of Chemical Engineering, Faculty of Engineering, Graduate School of Engineering, Kyusyu University, Fukuoka, Japan. ijima@apex.chem-eng.kyushu-u.ac.jp
Noguchi
A
A
Katsuno
T
T
Ono
T
T
Nakazawa
K
K
Funatsu
K
K
Kawakami
K
K
D000818:Animals; D004195:Disease Models, Animal; D019164:Liver, Artificial; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results