Cellular mechanisms for the repression of apoptosis.
Apoptosis, also known as programmed cell death, is a ubiquitous mode of cell death known to play an important role during embryogenesis, development, and adult cellular homeostasis. Disruption of this normal physiological cell death process can result in either excessive or insufficient apoptosis, which can lead to various disease states and pathology. Since most cells contain the machinery that brings about apoptosis, it is clear that living cells must contain inherent repressive mechanisms to keep the death process in check. In this review, we examine several modes of repression of apoptosis that exist in cells.
Bortner
Carl D
CD
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Bortner@niehs.nih.gov
Cidlowski
John A
JA
D000818:Animals; D017209:Apoptosis; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D002352:Carrier Proteins / Q000502:physiology; D020169:Caspases / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008928:Mitochondria / Q000187:drug effects; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D015843:Serpins / Q000502:physiology; D014764:Viral Proteins
D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; C506386:CFLAR protein, human; D002352:Carrier Proteins; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D015843:Serpins; D014764:Viral Proteins; C074641:interleukin-1beta-converting enzyme inhibitor; D020169:Caspases