Cellular mechanisms of calcium and vitamin D in the inhibition of colorectal carcinogenesis.
Convincing evidence is available showing that dietary calcium and vitamin D impede the development of colonic carcinogenesis. The major cellular modes of action of calcium and vitamin D which can contribute to the inhibition of colonic neoplasia are reviewed in this article. These consist of complex series of signaling events induced by the chemopreventive agents acting at various tiers of colonic cell organization.
Lamprecht
S A
SA
Strang Cancer Prevention Center, New York, NewYork 10021, USA.
Lipkin
M
M
D000230:Adenocarcinoma / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002118:Calcium / Q000502:physiology* / Q000627:therapeutic use; D002135:Calcium-Binding Proteins / Q000187:drug effects / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D015179:Colorectal Neoplasms / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D004032:Diet / Q000009:adverse effects; D005786:Gene Expression Regulation / Q000187:drug effects; D017491:Genes, APC; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D009386:Neoplastic Syndromes, Hereditary / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D011493:Protein Kinase C / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D047488:Retinoid X Receptors; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014807:Vitamin D / Q000502:physiology* / Q000627:therapeutic use
D002135:Calcium-Binding Proteins; D007527:Isoenzymes; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D014157:Transcription Factors; D014807:Vitamin D; D011493:Protein Kinase C; D002118:Calcium