[Hormonal contraception and epilepsy].
Attempts to optimize quality of life in woman with epilepsy should include a reliable method for birth control, including oral contraceptives (OC). One of these methods is hormonal oral contraception. The classic antiepileptic drugs (AEDs)--Phenytoin, Phenobarbital, Ethosuximide and Carbamazepine induce hepatic microsomal enzymes and decrease the production of estradiol and progesterone, that may be compromise the effects of OC. Recommendation for women taking OC include possible use of noninducing AEDs (Valproic acid), new AEDs--Lamotrigine, Gabapentin, Topiramate, Tiagabine or for patients taking inducing AEDs use of an OC containing > or = 50 micrograms. estrogen. Patients should be warned that midcycle bleeding indicates possible OC failure and that the absence of such bleeding is not an indication of OC effectiveness. Additional contraceptive methods are also advised. The authors report their own experience in 12 women taking AEDs and OC.
Bozhinova
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Bozhinov
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Porozhanova
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D000927:Anticonvulsants / Q000627:therapeutic use*; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage*; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008862:Microsomes, Liver / Q000201:enzymology; D011788:Quality of Life
D000927:Anticonvulsants; D003278:Contraceptives, Oral, Hormonal