Dissolution behaviour of hydrophilic matrix tablets containing two different polyethylene oxides (PEOs) for the controlled release of a water-soluble drug. Dimensionality study.
Hydrophilic matrix tablets containing polyethylene oxides as the retarding polymer have been successfully employed in the controlled release of drugs. To evaluate the relative influence of drug diffusion and polymer erosion mechanisms in the drug delivery process, we studied the hydration behaviour of matrix tablets containing a water-soluble drug and PEOs of two different molecular weights: Polyox WSRN 1105 (Mw = 0.9 x 10(6)) and Polyox WSRN 301 (Mw = 4 x 10(6)). The hydration rate, the extent of swelling, and the erosion rate of matrices containing the polymer, the drug and tableting excipients were evaluated in comparison to tablets made of pure polymer. The results of these studies on function of the release behaviour were then discussed. The results show that the higher molecular weight PEO swells to a greater extent and tends to form, upon hydration, a stronger gel, which is therefore less liable to erosion, if compared to the lower molecular weight PEO. This difference in the erosion behaviour can explain the different efficiencies of the two polymeric products in modulating the delivery rate of the water-soluble drug. Moreover, the presence of other soluble components (drug and excipients) in the dosage form enhances the erosion trend of the tablets with a consequent reduction of the efficiency of the polymer in drug release control.
Maggi
L
L
Department of Pharmaceutical Chemistry, University of Pavia, Italy. lauretta.maggi@unipv.it
Segale
L
L
Torre
M L
ML
Ochoa
Machiste E
ME
Conte
U
U
D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels; D008422:Materials Testing; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D014867:Water
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D013607:Tablets; D014867:Water; D011092:Polyethylene Glycols