Principles of cargo attachment to cytoplasmic motor proteins.
The attachment of cytoskeletal motor proteins to cargo-laden vesicles is crucial for efficient transport in intracellular membrane trafficking pathways. Recent studies have identified specific kinesin-binding and dynein-binding proteins that could serve as membrane-associated 'receptor' proteins for the respective motors. New insights have also emerged about the cargo-binding domains of the motor proteins, and the regulation of motor binding to cargoes.
Kamal
Adeela
A
Conforma Therapeutics Corporation, 9393 Towne Centre Drive, Suite 240, San Diego, CA 92121, USA. adeela@alum.mit.edu
Goldstein
Lawrence S B
LS
D000818:Animals; D001692:Biological Transport; D003593:Cytoplasm / Q000378:metabolism; D004398:Dyneins / Q000378:metabolism; D016547:Kinesins / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000737:chemistry / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism; D017434:Protein Structure, Tertiary; D022161:Transport Vesicles / Q000378:metabolism*
D020409:Molecular Motor Proteins; D009218:Myosins; D004398:Dyneins; D016547:Kinesins