title: A case of exaggerated mosquito-bite hypersensitivity with Epstein-Barr virus-positive inflammatory cells in the bite lesion.
abstract: We describe a unique patient with mosquito-bite hypersensitivity who had extremely high titres of Epstein-Barr virus antibodies. For many years he developed intractable ulcers on the sites of mosquito-bite. Epstein-Barr virus infection was detected in almost all inflammatory cells in the ulcers and in the peripheral blood lymphocytes by using in situ hybridization to Epstein-Barr virus-encoded small ribonucleic acids and by polymerase chain reaction to Epstein-Barr virus DNA. The inflammatory cells in the ulcers were positive for T-cell marker. Our results suggest that the Epstein-Barr virus infection in T cells may participate in the pathogenesis of exaggerated mosquito hypersensitivity and in delayed healing of ulcers on the sites of mosquito-bite.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohsawa
authors.forename: T
authors.initials: T
authors.lastname: Morimura
authors.forename: Y
authors.initials: Y
authors.lastname: Hagari
authors.forename: T
authors.initials: T
authors.lastname: Kawakami
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: K
authors.initials: K
authors.lastname: Ikuta
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Sairenji
authors.forename: T
authors.initials: T
authors.lastname: Matsuse
mesh_terms: D000293:Adolescent; D000818:Animals; D009033:Culicidae; D004279:DNA, Viral / Q000302:isolation & purification; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D007299:Insect Bites and Stings / Q000150:complications* / Q000276:immunology / Q000473:pathology; D007871:Leg Ulcer / Q000209:etiology* / Q000473:pathology / Q000821:virology; D008297:Male; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000821:virology*
chemical_list: D004279:DNA, Viral