title: Comparison of the effects of hypertonic saline and crystalloid infusions on haemodynamic parameters during haemorrhagic shock in dogs.
abstract: Haemorrhagic shock, a leading cause of mortality, frequently accompanies cardiac interventions. The administration of small volumes of hypertonic saline solutions and crystalloid solutions may reduce the severity and duration of shock, and result in a decrease in adverse outcomes. Under general anaesthesia, hypotension was induced in 12 healthy dogs. After 30 min, dogs received either hypertonic saline solution or lactated Ringer's solution for fluid, resuscitation. In both groups, decreases in haemodynamic variables were observed during the shock period. Following resuscitation, increases in haemodynamic variables were observed. This increase lasted longer in dogs receiving hypertonic saline. In both groups, haematocrit and oxygen content values decreased after resuscitation and lactate levels increased. During resuscitation, lactate levels decreased. Sodium and osmolarity increased with resuscitation, then subsequently decreased. In conclusion, in a model of haemorrhagic shock, the administration of hypertonic saline solutions provides haemodynamic stability and tissue oxygenation more rapidly.
authors.affiliation: Department of Cardiovascular Surgery, GATA Haydarpaşa Training Hospital, Istanbul, Turkey.
authors.forename: M H
authors.initials: MH
authors.lastname: Us
authors.forename: S
authors.initials: S
authors.lastname: Ozkan
authors.forename: L
authors.initials: L
authors.lastname: Oral
authors.forename: T
authors.initials: T
authors.lastname: Oğuş
authors.forename: H V
authors.initials: HV
authors.lastname: Acar
authors.forename: O
authors.initials: O
authors.lastname: Cakir
authors.forename: O
authors.initials: O
authors.lastname: Keskin
authors.forename: C
authors.initials: C
authors.lastname: Top
authors.forename: M
authors.initials: M
authors.lastname: Gökben
mesh_terms: D000818:Animals; D003460:Crystallization; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009994:Osmolar Concentration; D012771:Shock, Hemorrhagic / Q000503:physiopathology / Q000628:therapy*; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D012965:Sodium Chloride