A generic recognition-based approach to the acceleration of cycloaddition reactions.
[reaction: see text] Dicarboxylic acids accelerate the rate of cycloaddition reactions between either an azide or a furan and a maleimide through the formation of a reactive 1:1:1 complex stabilized by four hydrogen bonds.
Howell
Sarah J
SJ
Centre for Biomolecular Sciences, School of Chemistry, University of St. Andrews, North Haugh, St Andrews KY16 9ST, United Kingdom.
Spencer
Neil
N
Philp
Douglas
D