A TLC visualisation reagent for dimethylamphetamine and other abused tertiary amines.
Application of citric acid/acetic anhydride reagent (CAR), a colour reagent selective for tertiary amines in solution, improves detection of abused tertiary amino drugs on the TLC plate. The plate is pretreated by a brief immersion in phosphoric acid/acetone solution to suppress colouration. After suppressing, the plate is sprayed with CAR and heated at 100 degrees C, causing tertiary amines to turn red purple within 3 minutes. The sensitivity of this new CAR method is 2.5 to 15-times greater than that of conventional detection with Dragendorff reagent for some of the tertiary amines dimethylamphetamine, methylephedrine, levomepromazine, chlorpromazine, caffeine, theophylline, theobromine and nicotine. This present method provides rapid TLC detection of abused tertiary amino drugs such as phenethylamine, phenothiazine, xanthine derivative, nicotine and narcotics.
Kato
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N
Scientific Criminal Investigation Laboratory, Kanagawa Prefectural Police Headquarters, 155-1 Yamashita-cho, Naka-Ku, Yokohama 231-0023, Japan.
Ogamo
A
A
D000089:Acetic Anhydrides / Q000737:chemistry*; D000328:Adult; D002855:Chromatography, Thin Layer / Q000379:methods*; D019343:Citric Acid / Q000737:chemistry*; D006540:Herbicides / Q000652:urine; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000652:urine*; D010269:Paraquat / Q000652:urine; D010665:Phenylpropanolamine / Q000652:urine; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods*; D013566:Sympathomimetics / Q000652:urine*
D000089:Acetic Anhydrides; D006540:Herbicides; D013566:Sympathomimetics; D019343:Citric Acid; D010665:Phenylpropanolamine; D008694:Methamphetamine; C003714:dimethylamphetamine; D010269:Paraquat