title: Selective surface modification technique for improvement of chromatographic separation selectivity for sugar derivatives.
abstract: Highly cross-linked macroporous polymers were prepared utilizing ethylene dimethacrylate as a cross-linking agent, in the presence or absence of methyl-alpha-D-glucoside as a kind of template molecule with methacrylic acid as a functional monomer. After the preparation of the polymers, we applied a high temperature to the cross-linked polymers to study the changes of adsorption properties of the polymers for sugar derivatives including the template molecule utilized. Interestingly, the heat treatment up to 250 degrees C afforded improvement of relative adsorption affinity for several sugar derivatives including the template molecule, while heat treatment up to 150 degrees C did not afford those improvements. The detailed studies including polymers prepared using acrylic acid as a functional monomer instead of methacrylic acid prove that temperatures higher than the Tg temperature of the polymer derived from a functional monomer such as methacrylic acid and higher than the melting point (mp) of the sugar template are necessary to afford the observed improvement of relative affinity based on the surface modification effects through the heat treatment to cross-linked polymers.
authors.affiliation: Department of Polymer Science, Kyoto Institute of Technology, Japan. kenpc@ipc.kit.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Hosoya
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Yoshizako
authors.forename: Takuya
authors.initials: T
authors.lastname: Kubo
authors.forename: Tohru
authors.initials: T
authors.lastname: Ikegami
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tanaka
authors.forename: Jun
authors.initials: J
authors.lastname: Haginaka
mesh_terms: D002241:Carbohydrates / Q000737:chemistry* / Q000302:isolation & purification*; D002852:Chromatography, Ion Exchange; D003432:Cross-Linking Reagents; D005947:Glucose / Q000031:analogs & derivatives / Q000737:chemistry; D008689:Methacrylates; D011108:Polymers; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002241:Carbohydrates; D003432:Cross-Linking Reagents; D008689:Methacrylates; D011108:Polymers; C004919:ethylene dimethacrylate; D005947:Glucose