title: Sarcopenia and hypertrophy: a role for insulin-like growth factor-1 in aged muscle?
abstract: Sarcopenia is the loss of muscle mass associated with the aging process. Although systemic or circulating growth hormone and insulin-like growth factor-1 levels fall as we age, this is likely to be of lesser importance in regard to muscle mass than the role of locally produced insulin-like growth factor-1s generated in the muscle in response to exercise.
authors.affiliation: Department of Anatomy and Developmental Biology, Royal Free & University College Medical School, University College London, England.
authors.forename: Mahjabeen
authors.initials: M
authors.lastname: Hameed
authors.forename: Stephen D R
authors.initials: SD
authors.lastname: Harridge
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Goldspink
mesh_terms: D000375:Aging / Q000502:physiology*; D006801:Humans; D006984:Hypertrophy / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology*; D009133:Muscular Atrophy / Q000473:pathology
chemical_list: D007334:Insulin-Like Growth Factor I