Determination and pharmacokinetic study of ferrocene-A in blood serum of rabbits.
Ferrocene-A (ferrocenyl-1-phenyl-1-dioxy-1,4-butin-2) has significant antitumour and antibacterial properties. This study was designed to estimate main pharmacokinetic parameters of ferrocene-A (FC-A). These parameters are very important from the standpoint to elucidate the mechanism of pharmacological action of ferrocene-A. Examined substance was administrated intramuscularly and orally to rabbits. For determination of small quantities of ferrocene-A in a blood plasma liquid-liquid extraction and reversed-phase high performance liquid chromatography (HPLC) method was applied. Kinetic parameters were estimated using the one-compartment linear pharmacokinetic model.
Pochkhidze
Manana Sh
MSh
Department of Biology, Tbilisi State University, Chavchavadze Avenue 1, Tbilisi, Georgia.
Asatiani
Levan P
LP
Chitiashvili
Zaza J
ZJ
Rukhadze
Marina D
MD
Tsartsidze
Murad A
MA
D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D007273:Injections, Intramuscular; D008297:Male; D000075163:Metallocenes; D011817:Rabbits
D005296:Ferrous Compounds; D000075163:Metallocenes; C004998:ferrocene