title: MTR discloses subtle changes in the normal-appearing tissue from relatives of patients with MS.
abstract: The presence of normal-appearing brain tissue (NABT) changes was investigated in 30 first-degree relatives of patients with MS, using magnetization transfer ratio (MTR) histograms. When compared with controls, relatives of patients with familial (p = 0.01) and sporadic (p = 0.01) MS had lower NABT MTR histogram peak heights. This study suggests a reduction of truly normal NABT in asymptomatic relatives of patients with MS.
authors.affiliation: Department of Neurology, Medical Academy of Lodz, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Siger-Zajdel
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Selmaj
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics / Q000473:pathology*