title: Biodistribution of 99mTc-O4Na changes in adult rats whose mothers were malnourished during lactation.
abstract: 99mTc-O4Na biodistribution changes in malnourished adults rats. We evaluated this biodistribution in rats whose mothers were malnourished during lactation.
  
  
  METHODS
  On the first day of lactation the mothers were separated into 3 groups: control (C) group, protein-restricted (PR) group, and energy-restricted (ER) group. After weaning all pups received a control diet until 60 d, when they were injected with 99mTc-O4Na and killed after 30 min. We evaluated the absolute percentage injected dose (%ID) and the %ID per gram (%ID/g) in thyroid, stomach, heart, bone, kidney, lung, liver, brain, and testes.
  
  
  RESULTS
  In the PR group, the %ID and %ID/g were significantly higher in the stomach and lower in the thyroid than in the C group. In the ER pups, the %ID and %ID/g were higher in the liver, stomach, and testes than in the C group.
  
  
  CONCLUSIONS
  The mother's nutritional status during lactation affects the biodistribution of 99mTc-O4Na in the offspring, and this condition must be considered when nuclear medicine examinations are indicated.
authors.affiliation: Departamento de Nutrição Aplicada, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil. magna@uerj.br
authors.forename: Magna Cottini Fonseca
authors.initials: MC
authors.lastname: Passos
authors.forename: Cristiane F
authors.initials: CF
authors.lastname: Ramos
authors.forename: Sheila C P
authors.initials: SC
authors.lastname: Dutra
authors.forename: Mario
authors.initials: M
authors.lastname: Bernardo-Filho
authors.forename: Egberto Gaspar
authors.initials: EG
authors.lastname: Moura
mesh_terms: D000818:Animals; D005260:Female; D007774:Lactation / Q000502:physiology*; D008297:Male; D009748:Nutrition Disorders / Q000503:physiopathology*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m