title: Quality of life and systemic comorbidities in patients with ophthalmic disease.
abstract: OBJECTIVE
  To ascertain the effect of serious systemic comorbidities upon the quality of life of patients with ophthalmic diseases.
  
  
  METHODS
  Time tradeoff utility values were obtained in consecutive ophthalmic patients who presented with ocular disease. Multivariate analysis was undertaken to evaluate whether the systemic comorbidities of diabetes mellitus, heart disease, cancer, cerebrovascular accident, and/or renal failure requiring dialysis influenced ocular utility values.
  
  
  RESULTS
  Among the 390 patients with ocular diseases studied, 250 had the systemic comorbidities of diabetes mellitus, heart disease, cancer, stroke, and/or renal failure requiring dialysis, while 140 lacked these comorbidities. There was no statistically significant difference (p = 0.091) between the comorbidity and no comorbidity groups in self assessed quality of life as measured by ocular utility values after taking into account potentially confounding variables.
  
  
  CONCLUSIONS
  In patients with ocular disease, ocular utility values related to the visual loss do not appear to be affected by the presence of select, concomitant, serious systemic diseases. Thus, visual loss seems to cause a similar diminution in self assessed quality of life in those who do and do not have serious associated systemic comorbidities. This information has important implications for the calculation of cost effective analyses.
authors.affiliation: Center for Evidence-Based Health Care Economics, Flourtown, PA 19031, USA. Lissa1011@aol.com
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Brown
authors.forename: Gary C
authors.initials: GC
authors.lastname: Brown
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sharma
authors.forename: Hussein
authors.initials: H
authors.lastname: Hollands
authors.forename: Jennifer
authors.initials: J
authors.lastname: Landy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D048909:Diabetes Complications; D005128:Eye Diseases / Q000150:complications*; D005260:Female; D006331:Heart Diseases / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009369:Neoplasms / Q000150:complications*; D011788:Quality of Life; D020521:Stroke / Q000150:complications*