Duffy blood group genotypes among malaria patients in Rondônia, Western Brazilian Amazon.
We have compared Duffy blood group genotype distribution, as determined by polymerase chain reaction with allele-specific primers, in 68 Plasmodium vivax-infected patients and 59 non-vivax malaria controls from Rondônia, Brazil. Homozygosity for the allele Fy, which abolishes Duffy antigen expression on erythrocytes, was observed in 12% non-vivax controls but in no P. vivax patient. However, no significant association was found between Fy heterozygosity and protection against P. vivax. The Fy x allele, which has recently been associated with very weak erythrocyte expression of Duffy antigen, was not found in local P. vivax patients.
Cavasini
C E
CE
Laboratório de Parasitologia Molecular, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP.
Tarelho Pereira
F J
FJ
Ribeiro
W L
WL
Wunderlich
G
G
Ferreira
M U
MU
D001938:Brazil; D004375:Duffy Blood-Group System / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008288:Malaria / Q000235:genetics*
D004375:Duffy Blood-Group System