title: The relation between HLA-DQA1 genes and genetic susceptibility to duodenal ulcer in Wuhan Hans.
abstract: AIM:To study the genetic susceptibility of HLA-DQA1 alleles to duodenal ulcer in Wuhan Hans.METHODS:Seventy patients with duodenal ulcer and fifty healthy controls were examined for HLA-DQA1 genotypes.HLA-DQA1 typing was carried out by digesting the locus specific polymerase chain reaction amplified products with alleles specific restriction enzymes (PCR-RFLP), i.e.,Apal I, Bsaj- I, Hph I, Fok I, Mbo II and Mnl I.RESULTS:The allele frequencies of DQA10301 and DQA1-0102 in patients with duodenal ulcer were significantly higher and lower respectively than those in healthy controls (0.40 vs 0.20, P = 0.003, P(corret) = 0.024) and (0.05 vs 0.14, P = 0.012, but P(corret) > 0.05), respectively.CONCLUSION: DQA1(*)0301 is a susceptible gene for duodenal ulcer in Wuhan Hans, and there are immunogenetic differences in HLA-DQA1 locus between duodenal ulcer patients and healthy controls.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Du
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Deng
authors.forename: De-Yin
authors.initials: DY
authors.lastname: Lu
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Huang
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: Hou