title: Angiogenesis in the central nervous system: a role for vascular endothelial growth factor/vascular permeability factor and tenascin-C. Common molecular effectors in cerebral neoplastic and non-neoplastic "angiogenic diseases".
abstract: Human pathological conditions of the central nervous system (CNS) associated with angiogenesis (i.e. neovascularization) include neoplastic, as well as infectious, ischemic, and traumatic processes. Upregulation of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) and tenascin-C (TN-C) is spatially and temporally related to neovascularization. Spatially, VEGF/VPF and TN-C are both found at the site of neovascularization, but they are not detected in areas of normal brain or in areas without neovascularization. Temporally, VEGF/VPF and TN-C are found at the peak of angiogenesis and are not detected when angiogenesis had ceased.
authors.affiliation: Department of Pathology, New York University Medical Center, NY, USA. dz4@nyu.edu
authors.forename: D
authors.initials: D
authors.lastname: Zagzag
authors.forename: V
authors.initials: V
authors.lastname: Capo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001927:Brain Diseases / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D002490:Central Nervous System / Q000473:pathology*; D002648:Child; D016228:Endothelial Growth Factors / Q000502:physiology*; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology*; D019063:Tenascin / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D008222:Lymphokines; D019063:Tenascin; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors