title: Signet-ring cell carcinoma of unknown primary location. Metastatic to lower back musculature - remission following FU/FA chemotherapy.
abstract: The detection of gastrointestinal signet-ring cell carcinoma by endoscopy can be a diagnostic challenge. The main clinical features include atypical metastasis and a poor prognosis. We present a case of a metastasizing signet-ring cell carcinoma with unknown primary location arising in 71-year-old female. Following 6 cycles of a routine intravenous FU/FA chemotherapy, an almost complete remission could be observed. After 2 years of follow up, metastatic recurrence was detected to the lower back musculature. This case report emphasizes the difficulties in diagnosing signet-ring cell carcinoma by endoscopy and demonstrates an unusual clinical course.
authors.affiliation: Department of Medicine B, University of Münster. Jan_Heidemann@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Heidemann
authors.forename: H R
authors.initials: HR
authors.lastname: Gockel
authors.forename: G
authors.initials: G
authors.lastname: Winde
authors.forename: H
authors.initials: H
authors.lastname: Herbst
authors.forename: W
authors.initials: W
authors.lastname: Domschke
authors.forename: N
authors.initials: N
authors.lastname: Lügering
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D000368:Aged; D001415:Back; D001707:Biopsy, Needle; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging; D019042:Muscle Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D018482:Muscle, Skeletal / Q000473:pathology; D009382:Neoplasms, Unknown Primary / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D002955:Leucovorin; D005472:Fluorouracil