title: [Acquired warfarin resistance in a patient with mechanical heart valve].
abstract: We present a case report of a 37-year-old man with a mechanical mitral valve, who, presumably because of malabsorption, developed resistance to oral anticoagulant therapy. The patient was then treated with a replacement of the mechanical valve to biological valves, thereby eliminating the need for anticoagulant therapy. Our case report summarises the diagnostic approach to elucidate apparent resistance to anticoagulant therapy.
authors.affiliation: jpg@dadlnet.dk
authors.forename: J P
authors.initials: JP
authors.lastname: Gøtze
authors.forename: S
authors.initials: S
authors.lastname: Thorsen
authors.forename: S
authors.initials: S
authors.lastname: Haunsø
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D001705:Bioprosthesis; D004351:Drug Resistance; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery; D014859:Warfarin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D000925:Anticoagulants; D014859:Warfarin