title: The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat.
abstract: Osmolality changes evoked with intragastric administration of natural honey or mannitol, significantly decreased the gastric ulceration of rats induced by indomethacin. Together with this effect, a parallel increase was detectable in the mucosal level of endogenous prostacyclin. Although many processes may be involved in this phenomenon, the authors explain their data with a stimulating effect on gastric mucosal microcirculation due to osmolality changes.
authors.affiliation: Department of Biologie, Faculte des Sciences, Universite Ferhat Abbas, Setif, Algerie.
authors.forename: K
authors.initials: K
authors.lastname: Gharzouli
authors.forename: G A
authors.initials: GA
authors.lastname: Balint
authors.forename: M
authors.initials: M
authors.lastname: Galfi
authors.forename: A
authors.initials: A
authors.lastname: Rimanoczy
authors.forename: A
authors.initials: A
authors.lastname: Juhasz
mesh_terms: D000818:Animals; D011464:Epoprostenol / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006722:Honey; D007213:Indomethacin / Q000633:toxicity; D008353:Mannitol / Q000494:pharmacology; D009994:Osmolar Concentration; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism* / Q000628:therapy
chemical_list: D008353:Mannitol; D011464:Epoprostenol; D007213:Indomethacin