Embryogenesis of adriamycin-induced hindgut atresia in rats.
It was proposed that the pathogenesis of multiple intestinal atresias (MIA) in human fetuses is a consequence of malformative processes of the gastrointestinal tract rather than an ischemic process. Recently, MIA has been described in adriamycin-exposed rat fetuses. The aim of this study was to describe the embryogenesis of hindgut atresia (HA) in the adriamycin animal model. Timed-pregnant Sprague-Dawley rats were injected with adriamycin on days 6-9 of gestation. Embryos were removed on different gestational days during organogenesis and histologic sections were examined and compared with control specimens. In experimental embryos, HA was seen on day 13; however, the lumen was patent on day 12. HA was associated with abnormal vascular anatomy that was obvious on days 12 and 13. It is concluded that HA in adriamycin-exposed embryos occurs at the beginning of organogenesis. Although it was associated with an obvious vascular anomaly, further studies are required to find out whether it is ischemic in origin.
Merei
Jamal M
JM
Department of Pediatric Surgery, Jordan University of Science and Technology, P.O. Box 3030, Irbid-22110, Jordan.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000633:toxicity; D005260:Female; D007409:Intestinal Atresia / Q000139:chemically induced / Q000196:embryology* / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000970:Antineoplastic Agents; D004317:Doxorubicin