title: Isolation of 3' -O-acetylchloramphenicol: a possible intermediate in chloramphenicol biosynthesis.
abstract: 3' -O-acetylchloramphenicol, commonly formed from chloramphenicol by resistant bacteria, has been isolated from the antibiotic-producing organism. Biosynthetic experiments suggest that it is a protected intermediate in chloramphenicol biosynthesis, implicating acetylation as a self-resistance mechanism in the producing organism.
authors.affiliation: Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1.
authors.forename: Frank
authors.initials: F
authors.lastname: Gross
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Lewis
authors.forename: Mahmood
authors.initials: M
authors.lastname: Piraee
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: van Pee
authors.forename: Leo C
authors.initials: LC
authors.lastname: Vining
authors.forename: Robert L
authors.initials: RL
authors.lastname: White
mesh_terms: D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002701:Chloramphenicol / Q000031:analogs & derivatives / Q000096:biosynthesis*; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; C026822:chloramphenicol 3-acetate; D002701:Chloramphenicol