title: [Why does nitroglycerin tolerance appear?].
abstract: Nitroglycerin (NTG) and other organic nitrates are beneficial drugs for the treatment of acute forms of coronary artery disease. The major limitation of organic nitrates use in clinical practice is the rapid development of hemodynamic tolerance. In general mechanisms of tolerance can be categorized into two different groups. One group of mechanisms is related to changes in the vascular smooth muscle bioactivation of organic nitrates. The other mechanisms are related to physiological response to increase nitric oxide (NO) production.
authors.affiliation: Instytut Biochemii Lekarskiej Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
authors.forename: L
authors.initials: L
authors.lastname: Włodek
authors.forename: M
authors.initials: M
authors.lastname: Sokołowska
mesh_terms: D000208:Acute Disease; D000787:Angina Pectoris / Q000188:drug therapy*; D004361:Drug Tolerance; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009569:Nitric Oxide / Q000009:adverse effects / Q000494:pharmacology*; D005996:Nitroglycerin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide; D005996:Nitroglycerin