Resuppression of virus load after interruption in treatment with nevirapine and 2 nucleoside reverse-transcriptase inhibitors.
This retrospective chart review evaluated the effectiveness of reinitiation of treatment with nevirapine and dual nucleoside-analogue reverse-transcriptase inhibitors (NRTIs) after an interruption in antiretroviral therapy in 135 patients with human immunodeficiency virus type 1 RNA levels of <400 copies/mL who were receiving the same regimen. Reinitiation of a nevirapine regimen resulted in resuppression of virus load to <400 copies/mL in most patients who adhered to the regimen. Direct interruption of a non-NRTI regimen could lead to easier and more efficient structured protocols for treatment interruption.
Yozviak
J L
JL
Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.
Doerfler
R E
RE
Woodward
W C
WC
D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D019829:Nevirapine / Q000627:therapeutic use*; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome; D019562:Viral Load
D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine