title: A new nonparametric linkage statistic for mapping both qualitative and quantitative trait loci.
abstract: We describe an alternative nonparametric linkage (NPL) statistic to that of Kruglyak et al. [Am. J. Hum. Genet. 58:1347-63, 1996] that can be used with qualitative phenotypes, and is easily extended for use with quantitative phenotypes. We analyzed the Genetic Analysis Workshop 12 simulated isolated population data, replicate 1, using two phenotypes; affected status (AFF) a dichotomous phenotype and quantitative trait Q5, which was chosen since it was the most strongly associated with AFF. One false positive significant NPL score was observed for the AFF phenotype. For Q5 a single region on chromosome 1 reached genome-wide significance. The peak of this signal was for marker D01G137 at 135.1 cM with a quantitative trait locus (QTL)-NPL score of 4.19. The nearest marker to the true location of the major gene (MG5 at 137.1 cM) was D01G139 at position 135.8 cM, where the QTL-NPL score was still high at 4.08.
authors.affiliation: University of Utah, Myriad Genetics Inc., Salt Lake City, Utah, USA.
authors.forename: N J
authors.initials: NJ
authors.lastname: Camp
authors.forename: A
authors.initials: A
authors.lastname: Gutin
authors.forename: V
authors.initials: V
authors.lastname: Abkevich
authors.forename: J M
authors.initials: JM
authors.lastname: Farnham
authors.forename: L
authors.initials: L
authors.lastname: Cannon-Albright
authors.forename: A
authors.initials: A
authors.lastname: Thomas
mesh_terms: D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D018709:Statistics, Nonparametric