title: Value of first day angiography/angioplasty in evolving Non-ST segment elevation myocardial infarction: an open multicenter randomized trial. The VINO Study.
abstract: OBJECTIVE
  Direct angioplasty is an effective treatment for ST-elevation myocardial infarction. The role of very early angioplasty in non-ST-elevation infarction is not known. Thus, a randomized study of first day angiography/angioplasty vs early conservative therapy of evolving myocardial infarction without persistent ST-elevation was conducted.
  
  
  METHODS
  One hundred and thirty-one patients with confirmed acute myocardial infarction without ST-segment elevations were randomized within 24 h of last rest chest pain: 64 in the first day angiography/angioplasty group and 67 in the early conservative group (coronary angiography only after recurrent or stress induced myocardial ischaemia).
  
  
  RESULTS
  All patients in the invasive group underwent coronary angiography on the day of admission (mean randomization-angiography time 6.2 h). First day angioplasty of the infarct related artery was performed in 47% of the patients and bypass surgery in 35%. In the conservative group, 55% underwent coronary angiography, 10% angioplasty and 30% bypass surgery within 6 months. The primary end-point (death/reinfarction) at 6 months occurred in 6.2% vs 22.3% (P<0.001). Six month mortality in the first day angiography/angioplasty group was 3.1% vs 13.4% in the conservative group (P<0.03). Non-fatal reinfarction occurred in 3.1% vs. 14.9% (P<0.02).
  
  
  CONCLUSIONS
  First day coronary angiography followed by angioplasty whenever possible reduces mortality and reinfarction in evolving myocardial infarction without persistent ST-elevation, in comparison with an early conservative treatment strategy.
authors.affiliation: Cardiocenter, University Hospital Královské Vinohrady, 3rd Medical School of Charles University Prague, Prague, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Spacek
authors.forename: P
authors.initials: P
authors.lastname: Widimský
authors.forename: Z
authors.initials: Z
authors.lastname: Straka
authors.forename: E
authors.initials: E
authors.lastname: Jiresová
authors.forename: J
authors.initials: J
authors.lastname: Dvorák
authors.forename: R
authors.initials: R
authors.lastname: Polásek
authors.forename: I
authors.initials: I
authors.lastname: Karel
authors.forename: R
authors.initials: R
authors.lastname: Jirmár
authors.forename: L
authors.initials: L
authors.lastname: Lisa
authors.forename: T
authors.initials: T
authors.lastname: Budesínský
authors.forename: F
authors.initials: F
authors.lastname: Málek
authors.forename: P
authors.initials: P
authors.lastname: Stanka
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D004562:Electrocardiography; D023381:Endpoint Determination; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy*; D016019:Survival Analysis; D016896:Treatment Outcome