title: NK-associated receptors on CD8 T cells from treatment-naive HIV-infected individuals: defective expression of CD56.
abstract: OBJECTIVE
  This study addresses the detailed expression of natural killer (NK)- associated receptors on CD8 T lymphocytes in treatment-naive HIV-infected individuals.
  
  
  METHODS
  Experimental study analysing the expression of NK-associated receptors on peripheral blood T lymphocytes from HIV-infected individuals compared with healthy controls.
  
  
  METHODS
  Flow cytometry was used to analyse the expression of CD56, CD16, CD94, NKG2A, NKB1, CD161, CD244, and perforin, according to the CD28 phenotype, on CD8(bright) T cells obtained from treatment-naive HIV-infected individuals and from healthy controls.
  
  
  RESULTS
  The results showed that CD8(bright) T cells from treatment-naive HIV-infected individuals had a decreased expression of CD56 and that CD8(bright)CD56 cell numbers correlated with CD4 cell counts. NK-associated markers were preferentially expressed on CD8(bright)CD28 negative T cells, both in healthy controls and HIV-infected individuals. An increased expression of CD94, CD244, and perforin, which was the consequence of the expansion of the CD8(bright)CD28 negative T-cell subset, was also observed in HIV infection.
  
  
  CONCLUSIONS
  As the CD8(bright)CD56 T cells are the mature cytolytic effector cells, the defective expression of CD56 on CD8(bright) T cells shown in HIV-infected individuals could be involved in the decreased peripheral blood T-cell cytotoxicity found in HIV infection.
authors.affiliation: Department of Immunology, Reina Sofía University Hospital, University of Córdoba, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Tarazona
authors.forename: Olga
authors.initials: O
authors.lastname: DelaRosa
authors.forename: Javier G
authors.initials: JG
authors.lastname: Casado
authors.forename: Julián
authors.initials: J
authors.lastname: Torre-Cisneros
authors.forename: José L
authors.initials: JL
authors.lastname: Villanueva
authors.forename: María D
authors.initials: MD
authors.lastname: Galiani
authors.forename: José
authors.initials: J
authors.lastname: Peña
authors.forename: Rafael
authors.initials: R
authors.lastname: Solana
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D015415:Biomarkers; D018106:CD28 Antigens / Q000276:immunology; D018791:CD4 Lymphocyte Count; D019002:CD56 Antigen / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type; D018655:Lymphocyte Count; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology; D055651:NK Cell Lectin-Like Receptor Subfamily B; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011971:Receptors, Immunologic / Q000276:immunology*; D000071176:Signaling Lymphocytic Activation Molecule Family; D019562:Viral Load
chemical_list: D015703:Antigens, CD; D000954:Antigens, Surface; D015415:Biomarkers; C084093:CD244 protein, human; D018106:CD28 Antigens; D019002:CD56 Antigen; C527203:KLRB1 protein, human; C497869:KLRD1 protein, human; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D055651:NK Cell Lectin-Like Receptor Subfamily B; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family