[Effect of abdominal lavage with Chinese drugs on bacteria translocation in acute hemorrhagic necrotizing pancreatitis in rats].
OBJECTIVE
To investigate the effect of different abdominal lavage fluid on bacterial translocation in acute hemorrhagic necrotizing pancreatitis (AHNP) of rat model.


METHODS
One hundred and sixty Wistar rats were randomly divided into the control group, AHNP group, antibiotics group and Chinese drugs group. The treated group were treated with intraperitoneal lavage for 72 hours. The peritoneal fluid and blood samples were collected for bacterial culture. Pancreas were examined histopathologically.


RESULTS
In Chinese drugs group, the pathologic damage in pancreas were milder than that of AHNP group, and as compared with AHNP group, the bacterial positive rates of blood and peritoneal lavage fluid culture were reduced from 80% to 40% and 90% to 40% respectively.


CONCLUSIONS
AHNP impaired the gut barrier function which led to bacterial translocation from the gut to other organs. It plays an important role in intestinal infection secondary to AHNP. Abdominal lavage with Chinese drugs is effective in preventing intestinal bacterial translocation, it showed its protection on gut barrier function by alleviating the damage of intestinal mucosa and pancreatitis.
Gu
J
J
Surgical Department of Beijing Friendship Hospital, Capital Medical University, Beijing (100050).
Wang
Y
Y
Gao
D
D
D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004926:Escherichia coli / Q000502:physiology*; D005260:Female; D008297:Male; D019283:Pancreatitis, Acute Necrotizing / Q000382:microbiology* / Q000503:physiopathology; D010533:Peritoneal Lavage; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal