title: A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
abstract: The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease.
authors.affiliation: PET Facility, Department of Radiology, University of Pittsburgh, PA 15213, USA. mathisca@msx.upmc.edu
authors.forename: Chester A
authors.initials: CA
authors.lastname: Mathis
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Bacskai
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Kajdasz
authors.forename: Megan E
authors.initials: ME
authors.lastname: McLellan
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Frosch
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Hyman
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Holt
authors.forename: Yanming
authors.initials: Y
authors.lastname: Wang
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Huang
authors.forename: Manik L
authors.initials: ML
authors.lastname: Debnath
authors.forename: William E
authors.initials: WE
authors.lastname: Klunk
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D000682:Amyloid / Q000378:metabolism*; D000818:Animals; D052160:Benzothiazoles; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000000981:diagnostic imaging*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D051379:Mice; D008822:Mice, Transgenic; D008853:Microscopy; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry*; D014055:Tomography, Emission-Computed
chemical_list: D000682:Amyloid; D052160:Benzothiazoles; D019275:Radiopharmaceuticals; D013844:Thiazoles; C009462:thioflavin T