Experimental research on phospholipids variation of halothane on liver mitochondria.
AIM:To study the pathogenesis of hepatotoxicity of halothane.METHODS:The effect of different concentration of halothane and sevoflurane on mitochondrial membrane phospholipids composition of rat liver were analyzed using high performance liquid chromatography (HPLC) technology.RESULTS:Halothane at low concentration could degrade mitochondrial membrane major phospholipids and increase lysophosph-atidylcholine.CONCLUSION:The pathogenesis of halothane hepatotoxicity was the phospholipids variation on liver mitochondria.
Sui
Bo
B
Zhang
Guang-Ming
GM
Yu
Wei-Feng
WF
Wang
Xue-Min
XM
Ma
Yong-De
YD
Liu
Shu-Xiao
SX