Parameters for reliable results in genetic association studies in common disease.
It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.
Dahlman
Ingrid
I
JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK.
Eaves
Iain A
IA
Kosoy
Roman
R
Morrison
V Anne
VA
Heward
Joanne
J
Gough
Stephen C L
SC
Allahabadia
Amit
A
Franklyn
Jayne A
JA
Tuomilehto
Jaakko
J
Tuomilehto-Wolf
Eva
E
Cucca
Francesco
F
Guja
Cristian
C
Ionescu-Tirgoviste
Constantin
C
Stevens
Helen
H
Carr
Philippa
P
Nutland
Sarah
S
McKinney
Patricia
P
Shield
Julian P
JP
Wang
William
W
Cordell
Heather J
HJ
Walker
Neil
N
Todd
John A
JA
Concannon
Patrick
P
D020413:3' Untranslated Regions; D030541:Databases, Genetic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005828:Genetics, Population; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide
D020413:3' Untranslated Regions; D018664:Interleukin-12