title: A joint analysis of asthma affection status and IgE levels in multiple data sets collected for asthma.
abstract: We present a joint linkage analysis of eight data sets collected for asthma. Three of the data sets are full genome scans, while the remaining five concentrate on a 40-cM region on chromosome 5. We perform the analysis using one qualitative and one quantitative phenotype: asthma status and IgE level. Considering all data sets simultaneously, we do not find evidence for linkage to asthma affection status beyond the level expected to occur by chance twice per genome scan. In contrast, we observe significant linkage to IgE level on chromosome 6.
authors.affiliation: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, N., #D4100, P.O. Box 19024, Seattle, WA 98109-1024, USA.
authors.forename: K
authors.initials: K
authors.lastname: Markianos
authors.forename: S
authors.initials: S
authors.lastname: Carlson
authors.forename: M
authors.initials: M
authors.lastname: Gibbs
authors.forename: L
authors.initials: L
authors.lastname: Kruglyak
mesh_terms: D000328:Adult; D000483:Alleles; D001249:Asthma / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002896:Chromosomes, Human, Pair 6; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008432:Mathematical Computing; D015201:Meta-Analysis as Topic; D019655:Quantitative Trait, Heritable; D012984:Software
chemical_list: D007073:Immunoglobulin E