The T cell receptor V beta repertoire shows little change during treatment interruption-related viral rebound in chronic HIV infection.
In this study, changes in plasma virus load, peripheral blood CD4 T cell counts and the T cell repertoire were assessed in eight chronically HIV-infected individuals suspending antiretroviral therapy. Despite rapid increases in virus load and substantial CD4 T cell losses during treatment interruption, no marked changes in the T cell receptor beta chain repertoire were observed. The magnitude of associated T cell repertoire perturbation thus contrasts with that observed during primary HIV infection.
Grant
Michael
M
Immunology Program, Memorial University of Newfoundland, St John's, Canada.
Pardoe
Ingrid
I
Whaley
Mark
M
Montaner
Julio S G
JS
Harrigan
P Richard
PR
D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D002908:Chronic Disease; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000097:blood*; D016312:Treatment Refusal; D019562:Viral Load
D019380:Anti-HIV Agents; D012367:RNA, Viral; D016693:Receptors, Antigen, T-Cell, alpha-beta