Sumatriptan challenge in bipolar patients with and without migraine: a neuroendocrine study of 5-HT1D receptor function.
An association between bipolar disorder and migraine has been lately recognized and an abnormality of central serotonergic function is suggested as the underlying neurophysiological disturbance. To examine the role of serotonin in bipolar disorder and migraine, we used the neuroendocrine challenge paradigm, and we chose sumatriptan, a 5HT1D agonist, as the pharmacological probe. We studied nine bipolar patients with migraine, nine bipolar patients without it, seven migraine patients, and nine matched normal controls. A post-hoc analysis showed subsensitivity of serotonergic function, reflected in a blunted growth hormone response to sumatriptan challenge in bipolar patients who also suffered from migraine.
Mahmood
T
T
Psychopharmacology Research Group, Department of Psychological Medicine, University of Otago, Dunedin, New Zealand. tariq.mahmood@lcmhst-tr.northy.nhs.uk
Silverstone
T
T
Connor
R
R
Herbison
P
P
D000328:Adult; D001714:Bipolar Disorder / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000523:psychology; D009490:Neurosecretory Systems / Q000187:drug effects; D011388:Prolactin / Q000097:blood; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin / Q000187:drug effects*; D017366:Serotonin Receptor Agonists; D018170:Sumatriptan
D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D019382:Human Growth Hormone; D018170:Sumatriptan; D011388:Prolactin; D006854:Hydrocortisone