Phagocytosis and innate immunity.
Phagocytosis is an evolutionarily conserved process utilized by many cells to ingest microbial pathogens, and apoptotic and necrotic corpses. Recent investigation has revealed a fundamental requirement for two co-ordinated cellular processes--cytoskeletal alterations and membrane trafficking--in the phagocytic event. Some elements of this machinery are co-opted by certain pathogens to gain entry into host cells.
Greenberg
Steven
S
Columbia University, Departments of Medicine and Pharmacology/BB914, 630 West 168th Street, New York, NY 10032, USA. greenberg@cuccfa.ccc.columbia.edu
Grinstein
Sergio
S
D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D003599:Cytoskeleton / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology