Study on PDGF receptor beta pathway in glomerular formation in neonate mice.
The assembly of vascular endothelial cells (ECs) and smooth muscle cells is a critical event in the development of the cardiovascular system. Although the role of ECs in this event has been studied intensively, the cross-talk between the two cell components remains poorly understood. In this study, we blocked platelet-derived growth factor receptor (PDGFR) pathways in mice by antagonistic rat monoclonal antibody APB5 against murine PDGFR-beta and examined glomerular capillary formation.
Sano
H
H
Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan.
Yokode
M
M
Takakura
N
N
Takemura
G
G
Doi
T
T
Kataoka
H
H
Sudo
T
T
Nishikawa
S
S
Fujiwara
H
H
Nishikawa
S I
SI
Kita
T
T
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000254:growth & development*; D051379:Mice; D051381:Rats; D020239:Receptor Cross-Talk; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000037:antagonists & inhibitors / Q000502:physiology*
D000911:Antibodies, Monoclonal; D020797:Receptor, Platelet-Derived Growth Factor beta