title: Family-based tests of association and/or linkage.
abstract: The large literature on family-based tests of association and/or linkage is reviewed, concentrating on the underlying principles and on recent methodological developments. We explain the distinction between testing for association and testing for linkage, and give our views on the circumstances in which each is the appropriate null hypothesis.
authors.affiliation: Department of Applied Statistics, University of Reading, UK. j.whittaker@ic.ac.uk
authors.forename: J C
authors.initials: JC
authors.lastname: Whittaker
authors.forename: A P
authors.initials: AP
authors.lastname: Morris
mesh_terms: D000483:Alleles; D005190:Family; D008040:Genetic Linkage; D005819:Genetic Markers; D005826:Genetics, Medical; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D015233:Models, Statistical; D010375:Pedigree; D013223:Statistics as Topic
chemical_list: D005819:Genetic Markers