title: Thoracic metastasectomy in thyroid malignancies.
abstract: BACKGROUND
  Relatively little evidence exists to guide the decision pathway regarding thoracic metastasectomy for thyroid malignancy.
  
  
  METHODS
  Single-institution 10-year review.
  
  
  RESULTS
  Sixteen patients had surgical treatment for intrathoracic metastatic thyroid malignancy: 12 men and 4 women, mean age 43.7 years (range 19 to 77). Histopathologic type was papillary in 6 cases, follicular in 4, Hurthle cell in 3, and medullary in 3. Indication was either "bulky" disease (8 patients) or poor response to radiotherapy (8 patients). We performed 11 sternotomies and five thoracotomies. Operative mortality was 6.25%. Operative morbidity was 6.25%. Mean survival was 39.5 months (0 to 144). Nine patients died during follow-up (mean survival of 41.2 months). Six patients survived, 4 free of disease (mean survival 70 months) and 2 with further relapse (mean survival 17 months). Five-year survival was 32.5%.
  
  
  CONCLUSIONS
  The cohort studied is one of the largest in the literature on the topic. Surgical treatment achieved a reasonable survival in a small subgroup of patients where radiotherapy had failed or was deemed inappropriate because of the size or location of the tumor. Further follow-up and more observations will be required for evaluating these preliminary findings.
authors.affiliation: Department of Thoracic Surgery, Royal Brompton Hospital, London, England.
authors.forename: A D
authors.initials: AD
authors.lastname: Protopapas
authors.forename: A G
authors.initials: AG
authors.lastname: Nicholson
authors.forename: L
authors.initials: L
authors.lastname: Vini
authors.forename: C L
authors.initials: CL
authors.lastname: Harmer
authors.forename: P
authors.initials: P
authors.lastname: Goldstraw
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008131:London; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D008297:Male; D008479:Mediastinal Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000401:mortality; D012189:Retrospective Studies; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000401:mortality / Q000601:surgery*; D016896:Treatment Outcome