[Association of HLA-DRB1 allele and the susceptibility to alveolar echinococcosis in the west of China].
OBJECTIVE
To investigat the association of HLA-DRB1 alleles and the susceptibility to alveolar echinococcosis (AE).


METHODS
Thirty-five patients with AE in the high prevalence areas in the west of China were investigated for HLA-DRB1 gene by PCR/SSP technique. The results were compared with 104 normal healthy peoples.


RESULTS
Frequency of HLA-DRB1 * 040x was 26% in patient group, which was significantly higher than in control group (9.62%), with a relative risk (RR) of 4.45 (chi(2) = 13.67, P < 0.01), and with an etiological fraction of 0.20. Frequency of HLA-DRB1 * 0701 allele was decreased in patient group (patient 2.86%, control 13.94%; chi(2) = 6.67, P < 0.05), with preventable fraction of 0.30. While the frequencies of other DRB1 alleles were not significantly different.


CONCLUSIONS
Susceptibility to AE is strongly associated with the HLA-DRB1 * 040x allele. The high prevalence of human AE in this region was associated with genetic factor. HLA-DRB1 * 0701 geners resistant to Echinococcus multilocularis metacestode infection.
Li
F
F
Department of Parasistology, Tongji Medical University, Wuhan 430030, China.
Shi
Y
Y
Shi
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002681:China / Q000453:epidemiology; D004444:Echinococcosis, Hepatic / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains