Testicular-sparing surgery for the prepubertal testicular tumor. Experience of two cases with large cell calcifying Sertoli cell tumors.
OBJECTIVE
We review prepubertal germ cell tumors of testis in our institute and the Japanese registry and present 2 cases with a large cell calcifying Sertoli cell tumor (LCCSCT) and discuss the possibility of testis-sparing surgery.


METHODS
Incidence, age, pathology and clinical stages of prepubertal germ cell tumors are surveyed for 30 years at our department and 10 years of the malignant tumor registry of the Japanese Society of Pediatric Surgery. Two representative prepubertal boys with LCCSCT are presented. One of them was treated by partial orchiectomy.


RESULTS
The majority of testicular germ cell tumors in the prepubertal age were composed of embryonal cell carcinoma/yolk sac tumors or teratoma, occurred in preschool age, were limited to clinical stage I and did not metastasize irrespective of histology. Benign behavior which included recovery from hormonal derangement, no tumor recurrence and negative antisperm antigen was observed in 2 cases with LCCSCT who underwent either radical orchiectomy or partial orchiectomy.


CONCLUSIONS
Partial orchiectomy should be considered as a standard option in prepubertal schoolboys with a testicular mass if surgically feasible. This surgical treatment is safe and preserves fertility and is psychologically advantageous. It is not recommended for yolk sac tumors that may recur, however they are rare in prepubertal boys and can be differentiated preoperatively by prudent evaluation.
Nonomura
K
K
Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. k-nonno@med.hokudai.ac.jp
Koyama
T
T
Kakizaki
H
H
Murakumo
M
M
Shinohara
N
N
Koyanagi
T
T
D000293:Adolescent; D018236:Carcinoma, Embryonal / Q000453:epidemiology; D002648:Child; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D009919:Orchiectomy / Q000379:methods*; D012042:Registries; D012707:Sertoli Cell Tumor / Q000175:diagnosis / Q000601:surgery*; D013724:Teratoma / Q000453:epidemiology; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D016896:Treatment Outcome