title: Synthesis and biological activity of the new 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid.
abstract: A series of 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid 6, were synthesized and evaluated for their antitumor activity.
authors.affiliation: Biomedical Research Institute, Kolon Central Research Park, 207-2Mabuk-Ri, Guseong-Eup, Yongin-City, Kyunggi-Do 449-797, Republic of Korea. khkim@kolon.kr
authors.forename: Kwan-Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Keyong-Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Moon-Jong
authors.initials: MJ
authors.lastname: Noh
authors.forename: Youn-Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Ho-Jin
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005437:Flucytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D005437:Flucytosine