title: General health risk of periodontal disease.
abstract: The possibility that periodontal disease might influence the morbidity and mortality of systemic diseases constitutes a research topic of great current interest. Human periodontal disease is associated with a complex microbiota containing approximately 500 microbial taxa and various human viruses, many of which possess significant virulence potential. Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and other periodontopathic bacteria that are unique to the oral cavity and may disseminate to other body sites comprise the best-documented form of dental focal infection. However, systemically healthy individuals seem to be at low risk of acquiring acute non-oral diseases from direct infections by periodontal pathogens. Research data from various laboratories point to periodontal infections as a risk factor for chronic medical disorders, including cardiovascular disease, cerebrovascular accidents and low-birth-weight infants. However, recent epidemiological studies have failed to show a significant relationship between periodontal disease and cardiovascular disease. This review paper evaluates the current status of knowledge on dental focal infection and suggests avenues for further research into the topic of general health risks of periodontal disease.
authors.affiliation: MBA University of Southtern California, School of Dentristy, Department of Periodontology, Los Angeles 90089-0641, USA. jslots@usc.edu
authors.forename: J
authors.initials: J
authors.lastname: Slots
authors.forename: J J
authors.initials: JJ
authors.lastname: Kamma
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology; D002908:Chronic Disease; D004194:Disease / Q000209:etiology; D004198:Disease Susceptibility; D005260:Female; D005491:Focal Infection, Dental / Q000382:microbiology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D010510:Periodontal Diseases / Q000150:complications* / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000502:physiology; D011247:Pregnancy; D011248:Pregnancy Complications; D012307:Risk Factors; D020521:Stroke / Q000209:etiology