title: Structural genomics and signaling domains.
abstract: Many novel signal transduction domains are being identified in the wake of genome sequencing projects and improved sensitivity in homology-detection techniques. The functions of these domains are being discovered by hypothesis-driven experiments and structural genomics approaches. This article reviews the recent highlights of research on modular signaling domains, and the relative contributions and limitations of the various approaches being used.
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0580, USA. jh8e@nih.gov
authors.forename: James H
authors.initials: JH
authors.lastname: Hurley
authors.forename: D Eric
authors.initials: DE
authors.lastname: Anderson
authors.forename: Bridgette
authors.initials: B
authors.lastname: Beach
authors.forename: Bertram
authors.initials: B
authors.lastname: Canagarajah
authors.forename: Yew Seng Jonathan
authors.initials: YS
authors.lastname: Ho
authors.forename: Eudora
authors.initials: E
authors.lastname: Jones
authors.forename: Greg
authors.initials: G
authors.lastname: Miller
authors.forename: Saurav
authors.initials: S
authors.lastname: Misra
authors.forename: Matt
authors.initials: M
authors.lastname: Pearson
authors.forename: Layla
authors.initials: L
authors.lastname: Saidi
authors.forename: Silke
authors.initials: S
authors.lastname: Suer
authors.forename: Ray
authors.initials: R
authors.lastname: Trievel
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Tsujishita
mesh_terms: D000818:Animals; D019295:Computational Biology; D023281:Genomics / Q000379:methods*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary / Q000502:physiology*; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
chemical_list: D011506:Proteins