Double light chain producing lymphocytes: an enigma of allelic exclusion.
The infrequent double light chain producing lymphocyte (DLCPL) is discussed in the context of allelic exclusion. Principally allelic selection rather than allelic exclusion would suggest a role for the DLCPL in the normal B cell population rather than as an aberrance of B cell malignancy. Found primarily in the periphery, it is uncertain at what stage of B cell ontogeny the DLCPL might reside. Nevertheless, through the possible presentation of two functional surface receptors, the DLCPL could be capable of recognizing both self and nonself epitopes.
Diaw
L
L
Laboratory of Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Siwarski
D
D
Huppi
K
K
D000483:Alleles; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation; D019337:Hematologic Neoplasms / Q000235:genetics / Q000276:immunology; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000096:biosynthesis* / Q000235:genetics*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology*; D018448:Models, Immunological
D007147:Immunoglobulin Light Chains