title: Catheter effects in organ perfusion experiments.
abstract: In a typical isolated organ perfusion experiment, a substance is injected upstream of an organ and then collected at some distance downstream. To reach the organ from the injection site, and then from the organ to the collector, a solute passes through catheters, usually tubes with circular cross-sections. Catheters cause distortion to the concentration-time profile of the perfusion. In this paper, we analyse catheter distribution kinetics from a mathematical point of view, develop the function most suitable for modeling this distribution and successfully apply this function to experimental data.
authors.affiliation: Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.
authors.forename: Yuri G
authors.initials: YG
authors.lastname: Anissimov
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Bracken
authors.forename: Michael S
authors.initials: MS
authors.lastname: Roberts
mesh_terms: D002404:Catheterization; D006801:Humans; D008099:Liver; D008954:Models, Biological; D010477:Perfusion; D010599:Pharmacokinetics