title: Parathyroid hormone (1-34) increases attachment of PMMA cement to bone.
abstract: The attachment of an implant material to bone is related to the surface of the implanted material and the ability of the bone to form around the implant. Intermittent parathyroid (PTH) administration increases bone formation by stimulating osteoblastic activity. Little is known about the effect of PTH administration on orthopedic implant incorporation. The present study determined how PTH (1-34) administration influenced bone bonding, i.e., the bone-cement interfacial tensile strength, of vacuum-mixed polymethylmethacrylate (PMMA) bone cement (surface roughness; Ra, 4.8 microm). Bone bonding was evaluated by a detachment test. We used unloaded cement surfaces, which could be detached from the bone. Titanium plates were developed such that a cement fill was contained within a plate that was contained within a titanium holder. Thus, a flat cement surface came into contact with traumatized bone only, and the rest of the plate had no contact with tissue. After implantation of the plate in the left tibia, 20 adult male rats were injected daily with human PTH (1-34) at 60 microg/kg per injection (n = 10) or vehicle (n = 10); the animals were killed after 4 weeks. The plates were detached from the bone by a perpendicular force. PTH treatment increased the median pull-away strength (0.21 MPa), compared with that in the vehicle-treated rats, (0.04 MPa) (P = 0.02). The results suggest that PTH treatment may have the potential to enhance the incorporation of cemented orthopedic implants.
authors.affiliation: Department of Orthopedics, University Hospital, S-22185 Lund, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Skripitz
authors.forename: P
authors.initials: P
authors.lastname: Aspenberg
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000627:therapeutic use*; D008297:Male; D010281:Parathyroid Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D019904:Polymethyl Methacrylate / Q000627:therapeutic use*; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D013718:Tensile Strength / Q000187:drug effects
chemical_list: D001843:Bone Cements; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D019904:Polymethyl Methacrylate