[Metopic craniosynostosis, probable effect of intrauterine exposure to maternal valproate treatment].
Metopic craniosynostosis may be an adverse effect of valproic acid exposed fetus.


METHODS
We report two infants with metopic craniosynostosis, born to mothers who were treated with valproic acid. In one case, a prenatal diagnosis was made. In the other case, only the male dizygotic twin was affected.


CONCLUSIONS
Trigonocephaly may be a symptom of valproate embryofoetopathy detectable by antenatal ultrasound examination.
Chabrolle
J P
JP
Service de médecine néonatale, groupe hospitalier du Havre, 55bis, rue Gustave-Flaubert, 76600 Le Havre, France. jchabrolle@ch-havre-fr
Bensouda
B
B
Bruel
H
H
Simon
A
A
Poinsot
J
J
Ickowicz
V
V
Degre
S
S
D000014:Abnormalities, Drug-Induced / Q000175:diagnosis / Q000209:etiology*; D003398:Craniosynostoses / Q000139:chemically induced* / Q000175:diagnosis; D004200:Diseases in Twins; D004829:Epilepsy, Generalized / Q000188:drug therapy*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D014429:Twins, Dizygotic; D016216:Ultrasonography, Prenatal; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D014635:Valproic Acid