[The effects of taxol on different types of lymphoma cell lines].
OBJECTIVE
To observe the effects of new anticancer drug taxol on different types of lymphoma cells and to explore the value of its clinical application.


METHODS
Inverted microscope, light microscope, electron microscope, FCM and DNA gel electrophoresis were used to observe the effects of taxol on three different types of lymphoma cell lines, including Jurkat (T cell lymphoma), BJAB (B cell lymphoma, EBV negative) and Raji (B cell lymphoma, EBV positive).


RESULTS
Taxol can inhibit the growth and induce the apoptosis of all the three cell lines, while different sensitivities and apoptosis extent. Jurkat cells were most sensitive, mainly showing apoptosis; BJAB cells were last sensitive, showing G(2)/M arrest before apoptosis; Raji cells were last sensitive, mainly showing G(2)/M arrest and only part of cells going to apoptosis.


CONCLUSIONS
Taxol is a valuable chemotherapeutic agent for lymphoma. Its sensitivity differed with the types of lymphoma, EBV infection and the extent of induced apoptosis.
Zhou
X
X
Department of Pathology, Cancer Hospital, Shanghai Medical University, Shanghai 200032, China.
Xu
L
L
He
K
K
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis; D002455:Cell Division; D053938:DNA Fragmentation; D005434:Flow Cytometry; D006801:Humans; D019169:Jurkat Cells; D016393:Lymphoma, B-Cell; D017239:Paclitaxel / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel