title: [The TRP proteins, a rapidly expanding Ca2+ entry channel family and a new molecular target for drug development].
abstract: There is a rapidly expanding protein family which encompasses a broad repertoire of cation-selective channels serving as a continuous Ca2+ entry pathway into the cell. The transient receptor potential protein (TRP) and its relatives, which were originally thought to be Ca (2+)-permeable cation channels activated upon the stimulation of G-protein coupled and tyrosine kinase receptors, are now becoming promising candidates mediating a variety of cellular responses and functions such as mechano/chemo-transduction, oxidative stress, and cell survival/proliferation. This short paper briefly overviews the current knowledge about these proteins as a new target for drug discovery and development.
authors.affiliation: Department of Pharmacology, Graduate School of Medical Science, Kyushu University.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Inoue
authors.forename: Yushi
authors.initials: Y
authors.lastname: Ito
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Mori
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D002455:Cell Division; D002470:Cell Survival; D015195:Drug Design; D006801:Humans; D018384:Oxidative Stress; D050052:TRPC Cation Channels
chemical_list: D015220:Calcium Channels; D050052:TRPC Cation Channels