title: Militarinone A, a neurotrophic pyridone alkaloid from Paecilomyces militaris.
abstract: [structure: see text] A new pyridone alkaloid, militarinone A (1), was isolated by bioassay-guided fractionation from the mycelium of the entomogenous fungus Paecilomyces militaris. Its structure was established by extensive spectroscopic analysis. The compound features an unprecedented side chain and a 1,4-substituted cyclohexyl moiety not previously encountered in microbial metabolites. Militarinone A had a pronounced neurotrophic effect in PC-12 cells at 10 microM concentrations.
authors.affiliation: Institute of Pharmacy, Friedrich-Schiller-University Jena, D-07743 Jena, Germany.
authors.forename: Karen
authors.initials: K
authors.lastname: Schmidt
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Günther
authors.forename: Stefka
authors.initials: S
authors.lastname: Stoyanova
authors.forename: Barbara
authors.initials: B
authors.lastname: Schubert
authors.forename: Zengzhi
authors.initials: Z
authors.lastname: Li
authors.forename: Matthias
authors.initials: M
authors.lastname: Hamburger
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells / Q000187:drug effects; D010143:Paecilomyces / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
chemical_list: D000470:Alkaloids; D009414:Nerve Growth Factors; D011728:Pyridones; C449040:militarinone A