Prediction of drug clearance in humans from laboratory animals based on body surface area.
The object of the study was to develop a new allometric equation for clearance from laboratory animals to humans based on body surface area (BSA allometric method). Human clearances for 30 drugs were predicted from animal data obtained from the literature. The results predicted with the method were compared with those observed. The results were also compared with values predicted with clearance versus body weight (BW simple allometric method), the product of brain weight and clearance versus body weight (Cl x BRW method) and the product of maximum life span potential and clearance versus body weight (Cl x MLP method), respectively. Good predictions were found in 21 out of 30 with the BAS allometric method. Both BSA allometric method and BW simple allometric method can give good predictions of clearance in humans for many drugs. Similarly to BW simple allometric method, Cl x BRW method and Cl x MLP method, BSA allometric method may be used to accurately predict human clearance from laboratory animal data.
Liu
X D
XD
Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjning, People's of Republic of China. xdliu@jlonline.com
Chen
J
J
D000818:Animals; D000830:Animals, Laboratory / Q000378:metabolism*; D001830:Body Surface Area; D005544:Forecasting; D006801:Humans; D008657:Metabolic Clearance Rate / Q000502:physiology*; D008954:Models, Biological