title: Separation methods for camptothecin and related compounds.
abstract: This paper reviews working procedures for the analytical determination of camptothecin and analogues. We give an overview of aspects such as the chemistry, structure-activity relationships, stability and mechanism of action of these antitumor compounds. The main body of the review describes separation techniques. Sample treatment and factors influencing high-performance liquid chromatography development are delineated. Published high-performance liquid chromatographic methods are summarized to demonstrate the variability and versatility of separation techniques and a critical evaluation of separation efficiency, detection sensitivity and specificity of these methods is reported.
authors.affiliation: Pharmacy Department, University Hospital of Navarra, Pamplona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Zufía
authors.forename: A
authors.initials: A
authors.lastname: Aldaz
authors.forename: J
authors.initials: J
authors.lastname: Giráldez
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D002166:Camptothecin / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002166:Camptothecin