Role of p53 mutations on survival after pancreatoduodenectomy for ductal adenocarcinoma of the pancreatic head.
OBJECTIVE
To determine the role of p53 mutations on survival after pancreatoduodenectomy for adenocarcinoma of the pancreatic head.


METHODS
Resected specimens were assessed for expression of wild-type or mutated p53. Survival of p53-negative and- positive patients was investigated, and differences noted at 0.05 level.


RESULTS
Expression of wild-type p53 is associated with a significant improvement in overall survival, especially for patients without nodal metastases.


CONCLUSIONS
Preoperative p53 determination could enable further patient selection for aggressive surgery.
Gazzaniga
G M
GM
HPB Unit, First Division of General Surgery, Galliera Hospital, Genoa, Italy.
Papadia
F S
FS
Dezzana
M
M
Cappato
S
S
Filauro
M
M
Bandelloni
R
R
D000368:Aged; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D009367:Neoplasm Staging; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis