The blood-brain barrier and cerebral angiogenesis: lessons from the cold-injury model.
Brain injury is associated with an initial blood-brain barrier (BBB) breakdown, which can be life threatening. A second phase of BBB breakdown accompanies the angiogenesis occurring at the lesion margins. Studies of the molecular mechanisms involved in these processes are essential to determine targets for therapeutic intervention, as well as the time periods during which therapeutic intervention could ameliorate brain damage and thus improve the clinical outcome.
Nag
Sukriti
S
Neuropathology, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario M5T 2S8, Canada. nag@uhnres.utoronto.ca
D000818:Animals; D001812:Blood-Brain Barrier; D003080:Cold Temperature; D016228:Endothelial Growth Factors / Q000096:biosynthesis; D004727:Endothelium / Q000473:pathology; D006801:Humans; D008222:Lymphokines / Q000096:biosynthesis; D009389:Neovascularization, Pathologic; D012333:RNA, Messenger / Q000378:metabolism; D013687:Telencephalon / Q000098:blood supply* / Q000293:injuries; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors