title: Quantitative and qualitative assessment of reactive hematopoietic bone marrow in aplastic anemia using MR spectroscopy with variable echo times.
abstract: OBJECTIVE
  To assess quantitative and qualitative differences in water components between normal bone marrow and reactive hematopoietic marrow in aplastic anemia using magnetic resonance (MR) spectroscopy with variable echo times (TEs).
  
  
  METHODS
  Water content, T2 value of the water component, and signal change in water related to TE were assessed in normal bone marrow and reactive hematopoietic bone marrow by a stimulated echo acquisition mode with TEs of 30, 45, 60, and 90 ms.
  
  
  METHODS
  Six patients with aplastic anemia (13-84 years) and seven normal volunteers (25-38 years) were examined.
  
  
  CONCLUSIONS
  Reactive hematopoietic marrow showed significantly higher water content than normal bone marrow. The T2 value of water components tended to be longer in reactive hematopoietic marrow. Water signal ratio related to TE was significantly higher in reactive hematopoietic marrow. These results suggest a quantitative and qualitative difference in water components between normal and reactive hematopoietic bone marrow.
authors.affiliation: Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. ya-amano@nms.ac.jp
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Amano
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kumazaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000378:metabolism* / Q000503:physiopathology; D001834:Body Water / Q000737:chemistry*; D001853:Bone Marrow / Q000737:chemistry* / Q000503:physiopathology; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted