Efficacy of antiadhesive, antibiotic and antiseptic coatings in preventing catheter-related infections: review.
In recent years, central venous catheters (CVCs) are increasingly used in clinical practice. However, complications such as local or systemic infections are frequent for both temporary and indwelling vascular catheters. Annually, in the United States of America there are more than 200,000 cases of nosocomial bloodstream infections (BSIs), of which 90% are related to the use of an intravascular device. These infections are associated with increased morbidity and mortality, prolonged hospitalization and growing medical costs. Technological treatments of polymer surfaces including coating the catheter with antimicrobial substances may be promising tools for prevention of catheter-associated infections. A large number of surface-treated central venous catheters are now commercially available. In this paper the features and the clinical efficacy of different antimicrobial coatings are reviewed.
Donelli
G
G
Laboratorio di Ultrastrutture, Istituto Superiore di Sanità, Rome, Italy. donelli@iss.it
Francolini
I
I
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D001424:Bacterial Infections / Q000517:prevention & control*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002710:Chlorhexidine / Q000494:pharmacology; D006801:Humans; D012834:Silver / Q000494:pharmacology; D012837:Silver Sulfadiazine / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D001548:Benzalkonium Compounds; D012834:Silver; D002710:Chlorhexidine; D012837:Silver Sulfadiazine