Proliferative marker Ki-67 in gallbladder carcinomas: high expression level predicts early recurrence after surgical resection.
To evaluate the prognostic value of proliferative maker Ki-67, its expression was determined immunohistochemically in 37 gallbladder carcinomas (GBCs). A high Ki-67 index was significantly correlated with tumor lymphatic invasion (P=0.007) and vascular invasion (P=0.04). High Ki-67 index group and low Ki-67 index group showed different clinical courses. Five patients who experienced recurrences in high Ki-67 index group developed their recurrent diseases within one year after surgery and died soon after recurrence, while the recurrences (five cases) in low Ki-67 index group were distributed all stages after surgery. In conclusion, high Ki-67 index predicts early recurrence after surgery for GBCs.
Hui
Ai-Min
AM
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. huia@mail,nih.gov
Shi
Ya-Zhou
YZ
Li
Xin
X
Sun
Lin
L
Guido
Torzilli
T
Takayama
Tadatoshi
T
Makuuchi
Masatoshi
M
D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism*; D005260:Female; D005706:Gallbladder Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D013997:Time Factors
D019394:Ki-67 Antigen