Multi-component reactions and evolutionary chemistry.
Multi-component reactions (MCRs) provide a new approach towards the efficient synthesis of diverse compounds and compound libraries. MCRs are evolving from being purely a chemistry curiosity to being recognized as having increasing relevance for drug discovery in terms of lead discovery and optimization. The combination of MCR-type chemistry-planning with evolutionary in silico and in vitro prediction of drug potential or biological properties is a new and powerful tool in drug discovery.
Weber
Lutz
L
Morphochem, Gmunderstr. 37, D-81379 München, Germany. lutz.weber@morphchem.de
D020650:Combinatorial Chemistry Techniques / Q000639:trends*; D003198:Computer Simulation; D008956:Models, Chemical