Catheter effects in organ perfusion experiments.
In a typical isolated organ perfusion experiment, a substance is injected upstream of an organ and then collected at some distance downstream. To reach the organ from the injection site, and then from the organ to the collector, a solute passes through catheters, usually tubes with circular cross-sections. Catheters cause distortion to the concentration-time profile of the perfusion. In this paper, we analyse catheter distribution kinetics from a mathematical point of view, develop the function most suitable for modeling this distribution and successfully apply this function to experimental data.
Anissimov
Yuri G
YG
Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Queensland 4102, Australia.
Bracken
Anthony G
AG
Roberts
Michael S
MS
D002404:Catheterization; D006801:Humans; D008099:Liver; D008954:Models, Biological; D010477:Perfusion; D010599:Pharmacokinetics