[Synthesis of cholesterol-containing cationic amphiphiles with heterocyclic bases].
A number of cationic derivatives of cholesterol containing polar residues of N-methylimidazole, pyridine, N-methylmorpholine, and 4-N,N-dimethyaminopyridine were synthesized by the interaction of the corresponding heterocyclic bases with cholesterol 5-bromopentanoate followed by the treatment with methyl iodide in the case of tertiary amines. In addition, N-(4-cholesteryloxycarbonylbutyl)piperazine was obtained for the preparation of pH-sensitive liposomes.
Konstantinova
T V
TV
Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117571 Russia. konstantinova@httos.mitht.msk.ru
Klykov
V N
VN
Serebrennikova
G A
GA
D002412:Cations; D002784:Cholesterol / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared
D002412:Cations; D006571:Heterocyclic Compounds; D002784:Cholesterol