title: Annonaceous acetogenins from the leaves of Annona montana.
abstract: A novel Annonaceous acetogenin, montanacin F, with a new type of terminal lactone unit, was isolated from the leaves of Annona montana. Its structure was determined on the basis of spectral evidences and chemical methods, and a possible biosynthetic pathway was discussed. In addition, the cytotoxicity of montanacin F was evaluated in vitro against Lewis lung carcinoma (LLC) tumor cell lines. Furthermore, the previously isolated cytotoxic acetogenin annonacin against LLC was examined for in vivo antitumor activity with LLC tumor cells.
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.
authors.forename: Li-Quan
authors.initials: LQ
authors.lastname: Wang
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Norio
authors.initials: N
authors.lastname: Nakamura
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Qin
authors.forename: Can-Jun
authors.initials: CJ
authors.lastname: Li
authors.forename: Masao
authors.initials: M
authors.lastname: Hattori
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D005260:Female; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000637:transplantation
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D007783:Lactones; C473415:montanacin F