Catalytic oligonucleotides targeting EGR-1 as potential inhibitors of in-stent restenosis.
This brief review discusses recent strategies targeting the zinc finger transcription factor and immediate-early gene product Egr-1 with catalytic DNA in efforts to inhibit postangioplasty restenosis.
Khachigian
L M
LM
Centre for Thrombosis and Vascular Research, The University of New South Wales, Sydney, Australia. L.Khachigian@unsw.edu.au
D015906:Angioplasty, Balloon, Coronary; D023903:Coronary Restenosis / Q000235:genetics / Q000517:prevention & control* / Q000628:therapy; D004268:DNA-Binding Proteins / Q000235:genetics*; D051766:Early Growth Response Protein 1; D006801:Humans; D017874:Immediate-Early Proteins; D015607:Stents; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D017874:Immediate-Early Proteins; D014157:Transcription Factors