title: [Aspirin esterase: biochemical and clinical aspects of aspirin catabolism].
abstract: Aspirin, one of the most commonly used drugs, when entering human body is partially subjected to autolytic degradation to salicylic acid. However, hydrolytic degradation through enzymatic reaction, involving aspirin esterase is much more effective. It is obvious, that native drug, aspirin (acetylsalicylic acid) differs in respect of pharmacological properties from its catabolite, salicylic acid, a molecule without functionally important acetyl residue. Therapeutic implications of this simple esterolytic reaction are not yet fully understood. The paper presents current data on the biochemistry of aspirin esterase and clinical aspects of its activity.
authors.affiliation: Zakład Immunochemii Klinicznej II Katedry Chorób Wewnetrznych Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
authors.forename: A
authors.initials: A
authors.lastname: Goździalska
authors.forename: W
authors.initials: W
authors.lastname: Pajdak
mesh_terms: D001241:Aspirin / Q000378:metabolism; D002265:Carboxylic Ester Hydrolases / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D020156:Salicylic Acid / Q000378:metabolism
chemical_list: D002265:Carboxylic Ester Hydrolases; C018737:acetylsalicylic acid hydrolase; D020156:Salicylic Acid; D001241:Aspirin