[The effect of sandostatin on sphincter of Oddi in acute severe pancreatitis in dogs].
OBJECTIVE
To study the pressure change of sphincter of Oddi (SO) in acute severe pancreatitis (ASP) and the effect of sandostatin on it.


METHODS
Fifteen dogs were used and allocated into 2 groups: ASP untreated group and sandostatin group. The ASP model was prepared by retrograde ductal injection of a mixture of 5% taurocholic acid and autologous bile. SO manometic parameters including basal pressure (BP) and phasic contraction amplitude (PCA) were measured at each time spot before and after the preparation of ASP and after the administration of sandostatin.


RESULTS
BP was obviously increased after ASP preparation and sandostatin could significantly decrease the BP of SO in ASP group but not PCA.


CONCLUSIONS
Dysmotility of SO might play an important role in the severity and progression of ASP. Sandostatin may have beneficial effects in the treatment of ASP by decreasing BP of SO.
Zhu
Q
Q
Rui Jin Hospital, Shanghai Second Medical University, Shanghai 200025.
Yuan
Y
Y
Xia
L
L
Xu
J
J
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D008297:Male; D015282:Octreotide / Q000494:pharmacology*; D010195:Pancreatitis / Q000188:drug therapy* / Q000503:physiopathology; D009803:Sphincter of Oddi / Q000187:drug effects* / Q000503:physiopathology
D005765:Gastrointestinal Agents; D015282:Octreotide