[Myocardial protection and immunoregulation of minor bupleurum decoction and its decomposed preparations on coxsackie B3m viral myocarditis in mice].
OBJECTIVE
To study the effect of Minor Bupleurum Decoction (MBD) and its decomposed preparations, decomposition-1 (DC-1) and decomposition-2 (DC-2) in myocardial protection and immunoregulation on coxsackie virus B3m induced myocarditis in mice.


METHODS
Murine model of experimental myocarditis caused by coxsackie virus B3m was developed in Balb/c mice, and were treated by MBD, DC-1 and DC-2. Natural killer (NK) cell activity, T-lymphocyte subsets and histopathological change of myocardium were examined at various times after MBD, DC-1 and DC-2 were taken.


RESULTS
(1) MBD and DC-2 could increase the NK cell activity significantly, and also regulate the T-lymphocyte subsets, while DC-1 did not have this kind of effect; (2) All MBD, DC-1 and DC-2 could protect myocardium obviously, the effect of MBD is better than those of its decomposed preparations.


CONCLUSIONS
MBD and DC-2 had bi-directional regulation on NK cell activity and T-cell subsets, all the 3 groups could obviously protect myocardium.
Wang
X
X
Affiliated Hospital of Liaoning College of Traditional Chinese Medicine, Shenyang (110032).
Liu
F
F
Wei
K
K
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D003384:Coxsackievirus Infections / Q000276:immunology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D029822:Enterovirus B, Human / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000821:virology*; D016176:T-Lymphocyte Subsets / Q000276:immunology
D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; C018142:saiko-keishi-to