Cytotoxic alkaloids from Houttuynia cordata.
Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.
Kim
S K
SK
Korea Research Institute of Chemical Technology, Taejeon. kims@plaza.snu.ac.kr
Ryu
S Y
SY
No
J
J
Choi
S U
SU
Kim
Y S
YS
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification* / Q000494:pharmacology; D052859:Houttuynia; D006801:Humans; D026121:Indole Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D007546:Isoquinolines / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; C442781:Houttuynia cordata extract; D026121:Indole Alkaloids; D007546:Isoquinolines; C457228:aristolactam A; C457227:piperolactam A; C064674:aristololactam BII; C457230:cepharadione B; C457229:norcepharadione B; C457226:splendidine