Militarinone A, a neurotrophic pyridone alkaloid from Paecilomyces militaris.
[structure: see text] A new pyridone alkaloid, militarinone A (1), was isolated by bioassay-guided fractionation from the mycelium of the entomogenous fungus Paecilomyces militaris. Its structure was established by extensive spectroscopic analysis. The compound features an unprecedented side chain and a 1,4-substituted cyclohexyl moiety not previously encountered in microbial metabolites. Militarinone A had a pronounced neurotrophic effect in PC-12 cells at 10 microM concentrations.
Schmidt
Karen
K
Institute of Pharmacy, Friedrich-Schiller-University Jena, D-07743 Jena, Germany.
Günther
Wolfgang
W
Stoyanova
Stefka
S
Schubert
Barbara
B
Li
Zengzhi
Z
Hamburger
Matthias
M
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells / Q000187:drug effects; D010143:Paecilomyces / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
D000470:Alkaloids; D009414:Nerve Growth Factors; D011728:Pyridones; C449040:militarinone A