title: Myocardial viability: magnetic resonance assessment of functional reserve and tissue characterization.
abstract: The determination of myocardial viability is crucial in patients with left ventricular dysfunction resulting from acute myocardial ischemia or chronic coronary artery disease. Viable myocardium will most likely benefit from revascularization procedures. However, the revascularization of scar tissue will not lead to improvement of ventricularfunction andfurthermore bears unnecessary riskfor the patient. Currently, echocardiographic and radionuclide techniques are the most established methods for the assessment of presence and extent of viable myocardium. Magnetic resonance imaging (MRI) also provides multiple approaches for determining viability of acute ischemically injured and hibernating myocardium. MRI can assess contractile reserve in a manner similar to echocardiography. Additionally, contrast-enhanced MRI can characterize myocardial ischemic injury, including the ability to discriminate viable from nonviable zones. Several new contrast media have been introduced for this purpose. This review addresses the progress toward the goal of defining myocardial viability based on MR techniques and focuses on the current and future role of MR in the assessment of viable myocardium.
authors.affiliation: Department of Radiology, University of California, San Francisco, USA.
authors.forename: N
authors.initials: N
authors.lastname: Watzinger
authors.forename: M
authors.initials: M
authors.lastname: Saeed
authors.forename: M F
authors.initials: MF
authors.lastname: Wendland
authors.forename: H
authors.initials: H
authors.lastname: Akbari
authors.forename: G
authors.initials: G
authors.lastname: Lund
authors.forename: C B
authors.initials: CB
authors.lastname: Higgins
mesh_terms: D002462:Cell Membrane / Q000473:pathology; D003287:Contrast Media; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology*; D017682:Myocardial Stunning / Q000175:diagnosis / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D014022:Tissue Survival; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: D003287:Contrast Media