Antibiotic-induced recurring interstitial nephritis.
Acute interstitial nephritis (AIN) is often induced by drug therapy and accounts for 1%-3% of adult cases of renal failure. A 13-year-old white female with cystic fibrosis developed two episodes of biopsy proven AIN following antibiotic use over a 5-year period. The first episode resolved with pulse steroid therapy and the second resolved without intervention. Steroid therapy may play a role in aborting subsequent AIN attacks.
Sakarcan
Abdullah
A
Department of Pediatrics, Division of Pediatric Nephrology, University of South Carolina School of Medicine, Columbia, SC 29203, USA. abdullahsakarcan@hotmail.com
Marcille
Roxanne
R
Stallworth
James
J
D000293:Adolescent; D001706:Biopsy; D002969:Clavulanic Acids / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D010406:Penicillins / Q000009:adverse effects*; D010878:Piperacillin / Q000009:adverse effects*; D013982:Ticarcillin / Q000009:adverse effects*
D002969:Clavulanic Acids; D005938:Glucocorticoids; D010406:Penicillins; C043215:ticarcillin-clavulanic acid; D013982:Ticarcillin; D010878:Piperacillin; D008775:Methylprednisolone