FADD: A link between TNF family receptors and caspases in Parkinson's disease.
Fas-associating protein with a death domain (FADD) is a proximal adaptor protein of the tumor necrosis factor (TNF) receptor family death pathway. This human postmortem study showed a significant decrease in the percentage of FADD-immunoreactive dopaminergic (DA) neurons in the substantia nigra pars compacta of patients with PD compared with controls (-24.8%). This decrease correlated with the known selective vulnerability of nigral DA neurons in PD, suggesting that this pathway contributes to the susceptibility of DA neurons in PD to TNF-mediated apoptosis.
Hartmann
A
A
Institut National de la Santé et de la Recherche Médicale U 289, Hôpital de la Salpêtière, Paris, France.
Mouatt-Prigent
A
A
Faucheux
B A
BA
Agid
Y
Y
Hirsch
E C
EC
D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D002352:Carrier Proteins / Q000032:analysis* / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D004298:Dopamine / Q000032:analysis; D053200:Fas-Associated Death Domain Protein; D006801:Humans; D007150:Immunohistochemistry; D009474:Neurons / Q000737:chemistry; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D013378:Substantia Nigra / Q000737:chemistry* / Q000473:pathology
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C505533:FADD protein, human; D053200:Fas-Associated Death Domain Protein; D018124:Receptors, Tumor Necrosis Factor; D020169:Caspases; D004298:Dopamine