title: [Subreum efficacy and tolerance in patients with early rheumatic arthritis].
abstract: OBJECTIVE
  To evaluate effectiveness and tolerance of subreum in early rheumatoid arthritis (RA).
  
  
  METHODS
  44 patients with early rheumatoid arthritis. Subreum was given as a single drug and in combination with other basic drugs. Tolerance was evaluated in all the examinees, the effect--in 13 patients who finished the 6-month treatment by the articular syndrome, by ACR, DAS and HAQ criteria.
  
  
  RESULTS
  By DAS, a good response was achieved in 2 patients (15%), a satisfactory one--in 3 (23%) patients. By ACR criteria, a 20% and 50% improvement was obtained in 3 (23%) and 4 (31%) patients. Side effects were absent in 41 (93%) patients.
  
  
  CONCLUSIONS
  Subreum proved effective and well tolerable in early RA.
authors.forename: O V
authors.initials: OV
authors.lastname: Stepanets
authors.forename: N V
authors.initials: NV
authors.lastname: Chichasova
authors.forename: M B
authors.initials: MB
authors.lastname: Nasonova
authors.forename: E L
authors.initials: EL
authors.lastname: Nasonov
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000367:Age Factors; D000942:Antigens, Bacterial / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; C050501:OM 89