Physical, chemical, and biological properties of s-allylcysteine, an amino acid derived from garlic.
Physical, chemical, and biological properties of S-allylcysteine (SAC) were investigated. SAC showed stable properties under tested conditions, and its acute/subacute toxicity was very minor in mice and rats (LD(50) value >54.7 mM/kg po; >20 mM/kg ip). The pharmacokinetics of SAC was investigated after oral administration of garlic supplement containing SAC to human volunteers. SAC from garlic consumption was rapidly absorbed from the gastrointestinal tract, however, the half-life and excretion time were more than 10 h and 30 h, respectively.
Kodera
Yukihiro
Y
Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd., 1624 shimokoutachi, Koda-cho, Takata-gun, Hiroshima 729-1195, Japan. kodera_y@wakunaga.co.jp
Suzuki
Ayumi
A
Imada
Osamu
O
Kasuga
Shigeo
S
Sumioka
Isao
I
Kanezawa
Atsushi
A
Taru
Nobuo
N
Fujikawa
Masanori
M
Nagae
Shinji
S
Masamoto
Koji
K
Maeshige
Katsuhiko
K
Ono
Kazuhisa
K
D000284:Administration, Oral; D000818:Animals; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity*; D005260:Female; D005737:Garlic / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests
C065299:S-allylcysteine; D003545:Cysteine