[Comparative clinical and immunological parameters in convalescence of patients with icterohemorrhagic leptospirosis].
OBJECTIVE
To investigate clinico-immunological parallels of convalescent period in leptospiral jaundice (LJ).


METHODS
Clinical and immunological indices were studied in 121 LJ convalescents (97.6% males, age 17-45 years).


RESULTS
Acute leptospirosis period was characterized with polymorphic clinical picture impeding precise diagnosis and threatening with such complications as bacterial shock, acute renal failure, acute renal-hepatic failure, DIC-syndrome, respiratory distress. Convalescents for a long time exhibited polyorganic pathology, developed sepsis. In late convalescence one could observe affections of the heart, liver, kidneys, bones, nervous system, eyes. This can be explained by disorders in immunity, especially structural immunodeficiency, and commissures at the sites of hemorrhages.


CONCLUSIONS
Polyorganic pathology in leptospirosis convalescents arises because of immunity disorders which are not associated with the disease form. In late convalescence severe complications may accompany leptospiral jaundice.
Mel'nik
G V
GV
Degtiar'
L D
LD
D058186:Acute Kidney Injury / Q000209:etiology; D000293:Adolescent; D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000209:etiology; D012772:Shock, Septic / Q000209:etiology; D014895:Weil Disease / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*