title: Thalassemias and their dental implications.
abstract: Thalassemias constitute a form of anemia that pose clear problems in relation to dental treatment. Dental professionals must be aware of the treatment adaptations required in patients with severe forms of beta-thalassemia. Until medical research is able to afford a definitive solution to these diseases (thereby greatly simplifying the dental management of such patients), effort will continue to center on the improvement of available therapeutic modalities, with the aim of obtaining effective and inexpensive oral chelators and drugs that either individually or in combination allow increases in fetal hemoglobin levels. Undoubtedly, the use of such measures together with serial blood transfusions has made it possible for an ever increasing number of patients with beta-thalassemia to reach adult age, where the provision of integral rather than merely palliative dental treatment must be seriously considered. At present, the clinical orofacial manifestations caused by the erythroid mass expanding the facial bones - resulting in dental malocclusions and protrusions tend to be less intense as a result of early medical treatment. In the future, gene therapy may be expected to allow a normal facial appearance thanks to complete healing of the patient.
authors.affiliation: Facultad de Odontologia. Universidad de Granada. Spain. acutando@ugr.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Cutando Soriano
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Gil Montoya
authors.forename: Juan de Dios
authors.initials: Jde D
authors.lastname: López-González Garrido
mesh_terms: D002614:Chelating Agents / Q000627:therapeutic use; D019066:Facies; D006801:Humans; D008111:Liver Function Tests; D008310:Malocclusion / Q000209:etiology* / Q000628:therapy; D019767:Maxillofacial Abnormalities / Q000209:etiology* / Q000628:therapy; D013789:Thalassemia / Q000145:classification / Q000150:complications* / Q000628:therapy
chemical_list: D002614:Chelating Agents