Multiple roles of the tumor suppressor p53.
The tumor suppressor p53 controls numerous downstream targets that can result in variable outcomes, including apoptosis, transient growth arrest, and sustained growth arrest or senescence. The activation of p53, followed by its ability to play multiple roles in the control of genomic integrity or the elimination of damaged or tumorigenic cells, is performed by a complex process of cross-talk orchestrated to occur in the different compartments of the cell. Controlling performance of the many roles of p53 is a goal of many research groups and the focus of this review.
Bargonetti
Jill
J
Institute for Biomolecular Structure and Function, Department of Biology, Hunter College and Graduate School, City University of New York, New York City 10021, USA. bargonetti@genectr.hunter.cuny.edu
Manfredi
James J
JJ
D017209:Apoptosis / Q000235:genetics; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D016922:Cellular Senescence / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology*; D016158:Genes, p53 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology