title: [Cerebrospinal fluid viral load in HIV-1 positive hemophilic patients treated with HAART].
abstract: As HIV seropositive patients with undetectable CSF viral load have a lower likelihood of developing neurologic disease, the determination of CSF viral load levels may be useful to evaluate the efficacy of HAART. We compared plasma viral load levels with HIV-1 RNA CSF levels in 18 hemophilic patients without neurocognitive involvement under HAART. We detected a significant correlation between plasma viral load levels and CSF viral load levels. Fourteen patients with undetectable plasma viral load had undetectable RNA HIV-1 CSF levels as well. Four patients with detectable plasma viral load had detectable HIV-RNA in CSF, but the latter were significantly lower. Viral load is usually lower in non-blood fluids and HAART decreases the viral load in CSF as well as in blood.
authors.affiliation: Fundación Argentina de la Hemofilia e Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina. marcelocorti@ciudad.com.ar
authors.forename: M E
authors.initials: ME
authors.lastname: Corti
authors.forename: M F
authors.initials: MF
authors.lastname: Villafañe
authors.forename: P
authors.initials: P
authors.lastname: Baré
authors.forename: F
authors.initials: F
authors.lastname: Alves Rosa
authors.forename: M
authors.initials: M
authors.lastname: Cermelj
authors.forename: M
authors.initials: M
authors.lastname: Candela
authors.forename: R
authors.initials: R
authors.lastname: Pérez Bianco
authors.forename: M
authors.initials: M
authors.lastname: Tezanos Pinto
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000134:cerebrospinal fluid* / Q000150:complications / Q000188:drug therapy; D015497:HIV-1; D006467:Hemophilia A / Q000097:blood / Q000134:cerebrospinal fluid / Q000821:virology*; D006801:Humans; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid*; D019562:Viral Load
chemical_list: D012367:RNA, Viral