title: Breath hydrogen responses in infants using lactose-rice formula and regular lactose formula.
abstract: Starch thickened infant formulas have been shown to relieve regurgitation and increase caloric retention. We compared the completeness of digestion of the carbohydrates in lactose-rice formula (study formula) with routine infant formula in infants with GER. A prospective open study of 30 normal, well-nourished infants with simple regurgitation was conducted. The clinical history on regurgitation, stool pattern and baseline breath hydrogen (bH2) test were obtained at entry, with the infants still using their original routine infant formula, and after a wash out period of 7 days, during which they were fed only with study formula. Analysis of bH2 results showed lower levels of bH2 at 1, 2 and 3 hours with study formula compared with the original formula at the 2nd and 3rd hour (p<0.05). The effectiveness of the study formula in managing GER was demonstrated by the fact that 26 out of 30 had either "some improvement" or a "good response." Hardening of the stool pattern was reported in 13 of the 30 infants after 1 week of study formula. The mean of peak bH2 in study formula fed subjects with formed and firm/hard stool was significantly lower than in those with soft and pasty stool. In conclusion, this study has shown the effectiveness of rice thickened infant formulas in managing infants with GER. Rice-starch has an additional advantage of ease of digestion. The hardening of stool pattern was also frequently observed.
authors.affiliation: Division of Pediatric Gastroenterology & Nutrition, Veterans General Hospital-Taipei, Taiwan.
authors.forename: T C
authors.initials: TC
authors.lastname: Wu
authors.forename: B
authors.initials: B
authors.lastname: Hwang
authors.forename: P S
authors.initials: PS
authors.lastname: Lee
mesh_terms: D001944:Breath Tests; D005260:Female; D005764:Gastroesophageal Reflux / Q000628:therapy*; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D007223:Infant; D007225:Infant Food; D007785:Lactose / Q000008:administration & dosage*; D008297:Male; D011446:Prospective Studies
chemical_list: D006859:Hydrogen; D007785:Lactose