Allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in primary refractory prolymphocytic leukemia: graft-versus-leukemia effect without graft-versus-host disease.
A patient with progressive prolymphocytic leukemia (PLL) received an allogeneic stem cell transplant using a reduced intensity conditioning regimen to avoid prohibitive toxicities. Early in the post-transplant period, a high donor-derived CD8+ count was observed. One year from transplantation, the patient was in complete remission, fully donor chimeric and with a normal performance status, suggesting that this approach may represent a useful treatment option in patients with refractory PLL.
Castagna
L
L
Department of Medical Oncology and Hematology, Instituto Clinico Humanitas, 56 via Manzoni, 20089 Rozzano, Milan, Italy.
Nozza
A
A
Bertuzzi
A
A
Siracusano
L
L
Timofeeva
I
I
Santoro
A
A
D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control*; D020544:Graft vs Leukemia Effect; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015463:Leukemia, Prolymphocytic / Q000628:therapy*; D008875:Middle Aged; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous