[Association between cytochrome P-450 enzyme gene polymorphisms and Parkinson's disease].
OBJECTIVE
To explore the association between cytochrome P-450 enzyme gene polymorphisms and Parkinson's disease (PD).


METHODS
The polymorphisms of CYP1A1 and CYP2E1 gene were analyzed in 158 PD patients and 150 unrelated healthy controls with PCR-RFLP and ASA techniques.


RESULTS
(1) Of the 46 patients with early-onset PD, the frequency of the m2 allele was significantly higher than that in their matched controls, with an odds ratio of 2.459 (P < 0.005); the frequencies of the m1m2 and m2m2 genotypes were significantly higher than those in their matched controls with odds ratios of 2.99 (P < 0.01) and 6.22 (P < 0.025), respectively. In contrast, no differences were observed when the frequencies of individuals with the CYP1A1 MspI alleles or genotypes among patients with late-onset PD and their matched controls were compared (all P > 0.05). (2) Of the 46 patients with early-onset PD, the frequency of the G allele was significantly higher than that in their matched controls, with an odds ratio of 2.432 (P < 0.005); odds ratio was 6.167 in homozygotes for G allele (P < 0.01). Similarly, the frequency of the G allele was also significantly higher in late-onset PD patients than in their matched controls, with only an odds ratio of 1.649 (P < 0.01). In contrast, no differences were observed when the frequencies of individuals with the CYP1A1 exon 7 A4889G polymorphic locus genotypes among patients with late-onset PD and their matched controls were compared (P > 0.05). (3) No differences were observed when the frequencies of individuals with the CYP2E1 RsaI and PstI alleles or genotypes among patients with early- and late-onset PD and their matched controls were compared (all P > 0.05).


CONCLUSIONS
Our data suggest that CYP1A1 gene polymorphisms might be a genetic susceptible factor for early-onset PD, and CYP2E1 RsaI and PstI polymorphisms might not be a genetic susceptible factor for both early- and late-onset PD in the Chinese population tested.
Wang
J
J
Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, China.
Liu
Z
Z
Chen
B
B
D000328:Adult; D000483:Alleles; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D019363:Cytochrome P-450 CYP1A1