title: BCR-ABL rearrangement frequencies in chronic myeloid leukemia and acute lymphoblastic leukemia in Ecuador, South America.
abstract: Different BCR-ABL transcript variants occur more or less frequently, according to the leukemia type. We report the frequencies of BCR-ABL transcript variants studied in chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) patients in the Ecuadorian population. The frequencies found for CML patients in this study were 94.6% for the b2/a2 rearrangement and 5.4% for the b3/a2 rearrangement; whereas in ALL, all cases (100%) that presented the BCR-ABL rearrangement had the e1/a2 junction. Since our results differ from the frequencies previously reported, we suggest that this may be due to a different genetic background in the population involved in this study when compared to the populations analyzed in prior studies. Furthermore, we recommend a survey of the BCR-ABL transcript variants and their frequencies in different ethnic groups.
authors.affiliation: Laboratorio de Genética Molecular y Citogenética Humana, Departamento de Ciencias Biológicas, Pontificia Universidad Católica del Ecuador, P.O. Box 17-1-2184, Quito, Ecuador. cpazymino@puceuio.puce.edu.ec
authors.forename: César
authors.initials: C
authors.lastname: Paz-y-Miño
authors.forename: Ramiro
authors.initials: R
authors.lastname: Burgos
authors.forename: Santiago A
authors.initials: SA
authors.lastname: Morillo
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Santos
authors.forename: B Fernanda
authors.initials: BF
authors.lastname: Fiallo
authors.forename: Paola E
authors.initials: PE
authors.lastname: Leone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004484:Ecuador / Q000453:epidemiology; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D005787:Gene Frequency; D015321:Gene Rearrangement; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D016044:Fusion Proteins, bcr-abl