Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13-14 in Taiwanese families.
In order to evaluate the linkage of schizophrenia to loci at chromosome 15q, we genotyped six microsatellite markers at chromosome 15q11-14 in 52 Taiwanese schizophrenic families. Two phenotype models (narrow: DSM-IV schizophrenia only; and broad: including schizophrenia, schizoaffective, and other nonaffective psychotic disorders) were used to define the disease phenotype. Maximum nonparametric linkage scores (NPL scores) of 3.33 (P = 0.0003) and 2.96 (P = 0.0008) were obtained at the marker D15S976 under broad and narrow models, respectively. Positive linkage results were also observed at the marker D15S1360, previously reported to have significant linkage to a neurophysiological deficit of schizophrenia, with NPL scores of 2.71 (P = 0.003) and 2.78 (P = 0.002) under broad and narrow models, respectively. The results provide suggestive linkage evidence of schizophrenia to loci at chromosome 15q13-14 in an ethnically distinct Taiwanese sample.
Liu
C M
CM
Department of Psychiatry, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Hwu
H G
HG
Lin
M W
MW
Ou-Yang
W C
WC
Lee
S F
SF
Fann
C S
CS
Wong
S H
SH
Hsieh
S H
SH
D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005190:Family; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D013624:Taiwan
D004247:DNA