title: Phase II trial of pyrazoloacridine in patients with persistent or recurrent endometrial carcinoma: a Gynecologic Oncology Group Study.
abstract: OBJECTIVE
  The aims of this study were to determine the response rate of pyrazoloacridine (PZA) in patients with recurrent or persistent endometrial carcinoma and to describe the nature and degree of toxicity in this population.
  
  
  METHODS
  PZA was initially administered at a dose of 750 mg/m(2) intravenously over 3 h every 3 weeks but, due to toxicity, was subsequently reduced to 560 mg/m(2) at the same schedule.
  
  
  RESULTS
  Among 23 evaluable patients, 11 of whom had had prior chemotherapy, there was 1 (4.3%) partial response and no complete responses. Forty-eight percent of patients had grade 4 neutropenia. There was 1 treatment-related death, in a patient who had prior chemotherapy and radiotherapy.
  
  
  CONCLUSIONS
  This dose and schedule of PZA has insignificant activity in this population. The optimal PZA dose appears to vary between different populations and may be related to prior therapy.
authors.affiliation: Division of Gynecologic Oncology, University of California at San Diego, San Diego, California 92103, USA.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Plaxe
authors.forename: John A
authors.initials: JA
authors.lastname: Blessing
authors.forename: Nader
authors.initials: N
authors.lastname: Husseinzadeh
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Webster
authors.forename: Janet S
authors.initials: JS
authors.lastname: Rader
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Dunton
mesh_terms: D000166:Acridines / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D016889:Endometrial Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000166:Acridines; D000970:Antineoplastic Agents; D011720:Pyrazoles; C064541:NSC 366140