West Nile virus envelope protein: role in diagnosis and immunity.
The role of antibodies to the West Nile virus envelope (E) protein in serodiagnosis and protection was examined. The E protein was expressed and purified in recombinant form. Antibodies to the E protein were detected in patients with West Nile virus infection. Passive immunization with rabbit anti-E protein sera also partially protected mice from challenge with West Nile virus. The humoral response to the West Nile virus E protein is therefore useful as an aid in the diagnosis and may also play a role in immunity to infection.
Wang
T
T
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.
Anderson
J F
JF
Magnarelli
L A
LA
Bushmich
S
S
Wong
S
S
Koski
R A
RA
Fikrig
E
E
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D011994:Recombinant Proteins / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*; D014901:West Nile Fever / Q000175:diagnosis* / Q000276:immunology*; D014902:West Nile virus / Q000276:immunology*
D000914:Antibodies, Viral; D011994:Recombinant Proteins; D014759:Viral Envelope Proteins