title: Chondrosarcoma of the skull base.
abstract: OBJECTIVE
  Sarcomas of the skull base are challenging, potentially lethal tumors. Prognosis is considered poor. The present report reviews treatment options and presents a case of treatment with en bloc resection of the temporal bone and adjacent skull base.
  
  
  METHODS
  Single case report and literature review.
  
  
  RESULTS
  Extensive skull base resection for chondrosarcoma can be performed successfully and may be curative.
  
  
  CONCLUSIONS
  There is a role for en bloc resection of large areas of the skull base for treatment of chondrosarcoma. It appears that treatment combining surgery and radiation therapy is most likely to be effective.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, 1721 Pine Street, Philadelphia, PA 19103, U.S.A.
authors.forename: Brian
authors.initials: B
authors.lastname: Neff
authors.forename: Robert Thayer
authors.initials: RT
authors.lastname: Sataloff
authors.forename: Leslie
authors.initials: L
authors.lastname: Storey
authors.forename: Mary
authors.initials: M
authors.lastname: Hawkshaw
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Spiegel
mesh_terms: D000328:Adult; D002813:Chondrosarcoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D003399:Craniotomy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D011183:Postoperative Complications / Q000209:etiology / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D019291:Skull Base / Q000473:pathology / Q000601:surgery; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D013701:Temporal Bone / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed