Lens regeneration in mice under the influence of vitamin A.
The effect of vitamin A has been studied on lens regeneration in young (7 days old) as well as adult mice. A longitudinal slit was made under local anesthesia in the cornea over the lens. The lens was extracted intact through the incision. Intraperitonial injection of vitamin A (0.05 ml of 30 IU/ml in young and 0.05 ml of 50 IU/ml in adult) was given to the operated animals. Vitamin A was found to induce lens regeneration in not only young but also in adult mice. Regenerated lenses were similar in shape, size, transparency and histological features to normal intact lenses.
Shekhawat
D S
DS
Developmental Biology Laboratory, Department of Zoology, Dungar College, Bikaner 334 001, India.
Jangir
O P
OP
Prakash
A
A
Pawan
S
S
D000818:Animals; D007908:Lens, Crystalline / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D012038:Regeneration / Q000187:drug effects*; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A