title: [Apoptosis as a mechanism of tissue injury in hepatobiliary diseases].
abstract: BACKGROUND
  Cell death by apoptosis is a fundamental biologic process involved in many physiologic and pathophysiologic processes in the liver.
  
  
  OBJECTIVE
  To review the process of apoptosis, its cellular mechanisms, its regulation by external factors, and its role in pathophysiologic process and specific diseases of the liver.
  
  
  CONCLUSIONS
  An understanding of the cellular mechanisms of apoptosis and their dysregulation during pathophysiologic disturbances will help in understanding human liver diseases. The modulation of apoptosis may lead to novel therapeutic strategies for the treatment of a wide range of liver diseases.
authors.affiliation: Serviço de Transplante Hepático do Hospital de Clínicas da UFPR. mbparolin@hotmail.com
authors.forename: M B
authors.initials: MB
authors.lastname: Parolin
authors.forename: I J
authors.initials: IJ
authors.lastname: Reason
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D001660:Biliary Tract Diseases / Q000503:physiopathology*; D020169:Caspases / Q000502:physiology; D006801:Humans; D008107:Liver Diseases / Q000503:physiopathology*; D008928:Mitochondria / Q000502:physiology
chemical_list: D020169:Caspases