[Protective effect of Ginaton on rat liver microcirculation disturbance following liver xenotransplantation].
OBJECTIVE
To study the effect of Ginaton on liver microcirculation disturbance following liver xenotransplantation in rats.


METHODS
Ginaton was injected intravenously to recipients at a dosage of 14 mg/kg before graftng liver of guinea pigs. The portal blood flow (PBF) was measured by Doppler ultrasound at 0, 30 and 60 minutes after transplantation, and the pathologic changes of liver and heart were observed.


RESULTS
The reperfusion status of control group was poor and leukocyte infiltration appeared in the center of lobute following transplantation and myocardial cells were impaired. Significant reduction in PBF was found in rats following transplantation. Ginaton pretreatment distinctly ameliorated PBF. The speed of PBF was closely correlated with the pathologic changes following transplantation.


CONCLUSIONS
In the process of liver transplantation, ischemia reperfusion damage may lead to xenoheptic microcirculaton disturbance. Ginaton could improve the xenoheptic microcirculation and reduce ischemic reperfusion damage.
Zhang
Q
Q
Department of Surgery, Huashan Hospital, Shanghai Medical University, Shanghai 200040, China.
Rui
X
X
Cai
D
D
D000818:Animals; D006084:Graft Rejection / Q000473:pathology; D006168:Guinea Pigs; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D016031:Liver Transplantation / Q000009:adverse effects*; D008833:Microcirculation / Q000187:drug effects / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D011168:Portal System / Q000473:pathology; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D014183:Transplantation, Heterologous / Q000009:adverse effects*
D020011:Protective Agents