title: Percutaneous transluminal therapeutic ultrasound for high-risk thrombus-containing lesions in native coronary arteries.
abstract: We assessed the short-term outcome of percutaneous coronary ultrasound thrombolysis (CUT) for high-risk thrombus-containing lesions in native coronaries in the setting of acute coronary syndromes (ACS). Data were prospectively collected in a multicenter (n = 32) registry of consecutive ACS patients. The study population (n = 126) had mostly (84%) totally occluded vessels. The mean age of clot was 5.7 +/- 9.5 days (range, 0-60 days). CUT (41 kHz, 18 W) led to device success in 112 (89%) patients, with a residual stenosis of 69% +/- 20%. Adjunct PTCA or stenting was used in 97% of the patients. Procedural success was achieved in 124 (98%) patients, with a final residual stenosis of 6% +/- 10%. There were no major adverse clinical events during hospitalization. Ultrasound thrombolysis is a feasible procedure that offers a safe and probably effective adjuvant device solution for the treatment of high-risk, thrombus-containing lesions in the native coronary arteries.
authors.affiliation: Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Brosh
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Bartorelli
authors.forename: Alain
authors.initials: A
authors.lastname: Cribier
authors.forename: Juan
authors.initials: J
authors.lastname: Mesa
authors.forename: Luis
authors.initials: L
authors.lastname: Calderon
authors.forename: Thomas
authors.initials: T
authors.lastname: Martyn
authors.forename: Franz
authors.initials: F
authors.lastname: Amann
authors.forename: Alberto
authors.initials: A
authors.lastname: Sampaolesi
authors.forename: Walter
authors.initials: W
authors.lastname: Desmet
authors.forename: Jean
authors.initials: J
authors.lastname: Fajadet
authors.forename: Uri
authors.initials: U
authors.lastname: Rosenschein
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000628:therapy; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy; D011446:Prospective Studies; D012042:Registries; D013577:Syndrome; D015912:Thrombolytic Therapy / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods