Pectin-based microspheres: a preformulatory study.
This paper reports on (a) the production of pectin microspheres and (b) the influence of different experimental parameters and ionic crosslinking on morphological and dimensional characteristics of pectin microspheres. Morphological and dimensional characteristics of pectin were analyzed as a function of the type of pectin, the dispersing phase, the stirring speed, and the emulsifying agent. Crosslinking by calcium chloride and the encapsulation of antibiotics (i.e., metronidazol and tetracycline) gave particles morphologically similar to empty particles but with slower swelling kinetic.
Esposito
E
E
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
Cortesi
R
R
Luca
G
G
Nastruzzi
C
C
D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D008795:Metronidazole / Q000008:administration & dosage; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010368:Pectins / Q000737:chemistry*; D013501:Surface-Active Agents; D013752:Tetracycline / Q000008:administration & dosage
D004337:Drug Carriers; D013501:Surface-Active Agents; D008795:Metronidazole; D010368:Pectins; D013752:Tetracycline