title: Genotype and allele frequency of the 27-bp tandem repeat polymorphism in the endothelial nitric oxide synthase gene in Chinese population.
abstract: Genotype and allele frequency of the polymorphic 27-bp repeat, a variable number of tandem repeats (VNTR) located in intron 4 of the endothelial nitric oxide synthase gene, were analyzed in 316 healthy Chinese individuals. Four genotypes, namely 6/5-repeats heterozygous, 5/5-repeats homozygous, 5/4-repeats heterozygous and 4/4-repeats homozygous, were identified. Both observed genotype and allele frequencies of this VNTR in Chinese were similar to those of Japanese, while the 4/4-repeats genotype differed significantly from that of Caucasians in Spain, and all ones did from those of African-American in United States.
authors.affiliation: Department of Biochemistry & Molecular Biology, Institute of Radiation Medicine, Military Medical College, Beijing, China.
authors.forename: P
authors.initials: P
authors.lastname: Lu
authors.forename: X
authors.initials: X
authors.lastname: Lü
authors.forename: R Y
authors.initials: RY
authors.lastname: Xing
authors.forename: Q Y
authors.initials: QY
authors.lastname: Sun
authors.forename: L
authors.initials: L
authors.lastname: Han
authors.forename: S H
authors.initials: SH
authors.lastname: Wu
authors.forename: H
authors.initials: H
authors.lastname: Lan
authors.forename: X F
authors.initials: XF
authors.lastname: Zheng
mesh_terms: D000483:Alleles; D001483:Base Sequence; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences
chemical_list: C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III