title: Risk of gastric injury with enteric- versus nonenteric-coated aspirin.
abstract: OBJECTIVE
  To evaluate through clinical trials the risk of various aspirin preparations on the gastric mucosa.
  
  
  METHODS
  Articles reporting clinical research were accessed through MEDLINE (1980-November 1998). Key search terms included enteric-coated aspirin, buffered aspirin, and gastrointestinal (GI) bleeding.
  
  
  RESULTS
  Aspirin products are known to cause GI bleeding. Enteric-coated aspirin may provide an additional protective effect on gastric mucosa compared with buffered aspirin. An evaluation of studies comparing various aspirin preparations and the risk of gastric mucosal injury was conducted.
  
  
  CONCLUSIONS
  For long-term use, enteric-coated aspirin may provide a safer alternative than buffered aspirin; however, further studies are necessary.
authors.affiliation: Pharmacy Department, Saint Joseph's Hospital, Tampa, FL, USA. Dalia.Banoob@medmanagement.com
authors.forename: Dalia W
authors.initials: DW
authors.lastname: Banoob
authors.forename: William W
authors.initials: WW
authors.lastname: McCloskey
authors.forename: William
authors.initials: W
authors.lastname: Webster
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects*; D016022:Case-Control Studies; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000453:epidemiology*; D013608:Tablets, Enteric-Coated
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013608:Tablets, Enteric-Coated; D001241:Aspirin