Selective cross-linking to the adenine of the TA interrupting site within the triple helix.
The triplex-forming oligonucleotide incorporating the new nucleoside derivative (2) that connects the 2-amino-6-vinylpurine moiety to the 2-deoxyribose unit with an ethyl spacer has exhibited highly selective cross-linking reaction to the adenine of the TA interrupting site within the triple helix.
Nagatsugi
Fumi
F
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Matsuyama
Yoshihisa
Y
Maeda
Minoru
M
Sasaki
Shigeki
S
D000225:Adenine / Q000737:chemistry*; D020029:Base Pairing / Q000187:drug effects; D003432:Cross-Linking Reagents; D003596:Cytosine / Q000737:chemistry; D003855:Deoxyribose / Q000737:chemistry*; D007202:Indicators and Reagents; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000737:chemistry*; D011687:Purines / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
C432203:2-amino-6-vinylpurine; D003432:Cross-Linking Reagents; D007202:Indicators and Reagents; D009841:Oligonucleotides; D011687:Purines; D014753:Vinyl Compounds; D003855:Deoxyribose; D003596:Cytosine; D000225:Adenine