Effects of silver sulphadiazine on the production of exoproteins by Staphylococcus aureus.
The effects of subinhibitory concentrations of silver sulphadiazine (AgSD) on exoprotein production in Staphylococcus aureus strains T1, T4, RN4282 and RN 4282agr were studied. AgSD markedly increased levels of toxic shock syndrome toxin (TSST)-1 in strains T4 and RN4282. This effect was independent of agr and AgSD restored TSST-1 production to the wild-type level in RN 4282agr. AgSD had no effect on enterotoxin A or coagulase activity in strains T1 or T4. Strain T4 produced enterotoxin C at high levels and no effect was observed with AgSD. AgSD repressed metalloprotease production in strain T4 but the overall protease activity remained the same. No change in proteolytic activities was seen in strainT1 with AgSD. Molecular mechanisms for these observations are discussed.
Edwards-Jones
Valerie
V
Foster
H A
HA
Department of Biological Sciences, Manchester Metropolitan University, Chester Street, Manchester M1 5GD and *Division of Biological Sciences, School of Environment and Life Sciences, University of Salford, The Crescent, Salford, Lancs M5 4WT.
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001427:Bacterial Toxins; D003030:Coagulase / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D004768:Enterotoxins / Q000096:biosynthesis*; D012772:Shock, Septic / Q000382:microbiology*; D012837:Silver Sulfadiazine / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*; D018089:Superantigens
D000891:Anti-Infective Agents, Local; D001427:Bacterial Toxins; D003030:Coagulase; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; C026066:enterotoxin A, Staphylococcal; C034959:enterotoxin C, staphylococcal; D010450:Endopeptidases; D012837:Silver Sulfadiazine