Combinatorial chemistry in anti-infectives research.
The ever-increasing resistance to current anti-infective drugs has become a major concern to the medical community. As a result, research efforts have been stepped up with the ultimate goal to provide new, more effective and safer antimicrobial treatments that will overcome the resistance problem. In this context, advances in molecular biology, automation and combinatorial chemistry will play a crucial role in the timely introduction of these products onto the market. How the application of combinatorial techniques can impact anti-infectives research will be reviewed using illustrative examples.
Wijkmans
Jac C H M
JC
OSI Pharmaceuticals, Oxford, UK OX4 6LY. jwijkmans@osip.com
Beckett
R Paul
RP
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance
D000900:Anti-Bacterial Agents