Unusual morphology in a case of large granular cell leukemia.
Large granular lymphocyte proliferative status represents a group of clonal and nonclonal lymphoproliferative disorders of natural killer (NK) or T-cell lineages with common morphological features. Cellular differences may sustain the clinical polymorphism observed in these disorders. Here we report a case of large granular lymphocyte disease unusually expressing CD4+CD8+ clonal T cells and atypical cell morphology in bone marrow.
Galimberti
S
S
Hematology Division, Department of Oncology, Transplants and Advanced Technologies, University of Pisa, Ospedale S.Chiara, Via Roma 67, 56100 Pisa, Italy.
Riccioni
R
R
Azzarà
A
A
Testi
R
R
Fazzi
R
R
Testi
C
C
Petrini
M
M
D001172:Arthritis, Rheumatoid / Q000150:complications; D001854:Bone Marrow Cells / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D003928:Diabetic Nephropathies / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008214:Lymphocytes / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000150:complications; D001749:Urinary Bladder Neoplasms / Q000150:complications