Braking of expiratory airflow in obese pigs during wakefulness and sleep.
Braking of expiratory airflow is a phenomenon prominently seen in neonates where it is thought to defend end-expiratory lung volume. This paper describes pronounced expiratory braking in an adult animal, the obese Vietnamese pot-bellied pig. Three obese pigs were chronically instrumented for recording of intrapleural pressure and bioelectric signals related to sleep. Airflow was measured by a pneumotachograph attached to a facemask. Expiratory airflow resistance was calculated for 10 consecutive expirations during wakefulness, NREM, and REM sleep. All animals demonstrated a biphasic expiratory flow pattern characterized by an initial plateau in flow at a low value followed by a rapid increase later in expiration. Airflow resistance during early expiration was on average four-fold higher than during late expiration. A striking observation was the maintenance of pronounced expiratory braking during NREM and REM sleep. Expiratory braking in these animals is likely due to laryngeal mechanisms and may serve to preserve end-expiratory lung volume or improve hemodynamics.
Tuck
S A
SA
Faculty of Medicine, University of Calgary, AB, T2N 4N1, Calgary, Canada. stephanie.tuk@mcgill.ca
Dort
J C
JC
Remmers
J E
JE
D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D009765:Obesity / Q000503:physiopathology*; D017286:Polysomnography; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012123:Pulmonary Ventilation / Q000502:physiology; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D013552:Swine; D014851:Wakefulness / Q000502:physiology*