title: Association of heart rate response with scan and left ventricular function on adenosine myocardial perfusion imaging.
abstract: To evaluate the association of heart rate (HR) response with abnormal scan and/or left ventricular (LV) function in patients undergoing adenosine myocardial perfusion imaging, we retrospectively studied 188 consecutive patients who underwent a standard adenosine stress test (without exercise) and myocardial perfusion imaging (MPI) using technetium-99m sestamibi radioisotope. Change in HR was calculated by subtracting HR at rest from peak HR. The percentage change in HR was calculated. All patients underwent stress and resting single-photon emission computed tomography (SPECT) imaging. LV ejection fraction (EF) was calculated using gated SPECT. Mean age was 60 +/- 12 years and 135 of the patients (72%) were women. We divided the patients into 2 groups: group 1 (142 patients, 75%) had normal scans and group 2 (46 patients, 25%) had abnormal scans; abnormal scans were defined as presence of either fixed defects, reversible defects, or both. Average HR increased by 29 beats/min in the normal scan group compared with 19 beats/min in the abnormal scan group (p = 0.0004). Forty-seven patients (25%) had reduced EF (<45%). This group had an average HR and percentage HR increase of 20 beats/min (29%) compared with an increase of 29 beats/min (44%) in patients with normal EF (p = 0.002 and p = 0.002, respectively). Thus, a diminished HR response had a significant association with both an abnormal scan and reduced EF on adenosine MPI.
authors.affiliation: Division of Cardiology, Department of Medicine, Bronx Lebanon Hospital Center, Bronx, New York 10457, USA.
authors.forename: Aseem
authors.initials: A
authors.lastname: Vashist
authors.forename: Eliot N
authors.initials: EN
authors.lastname: Heller
authors.forename: Steve
authors.initials: S
authors.lastname: Blum
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Brown
authors.forename: Narendra C
authors.initials: NC
authors.lastname: Bhalodkar
mesh_terms: D000241:Adenosine; D016009:Chi-Square Distribution; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D017256:Technetium Tc 99m Sestamibi; D000241:Adenosine