Strategies to find new genes involved in drug metabolism.
Pharmacogenomics is a field that is applying the new methods of molecular genetics to explain the genetic basis of an individual's reaction to drugs. One example from the literature of variations in a single gene being predictive of drug metabolism is described, in addition to methods of testing a gene to see if it is associated with poor metabolism of the drug. An explanation is given of why linkage and association studies are used. Candidate gene studies are most frequently used but whole-genome scans are also described. Case-control studies or transmission disequilibrium tests are used to investigate phenotype and genotype association.
Sheffield
L J
LJ
Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia. sheffld@cryptic.rch.unimelb.edu.au
D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D010599:Pharmacokinetics; D010641:Phenotype; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D019389:Cytochrome P-450 CYP2D6