Malignant breast tumor phospholipid profiles using (31)P magnetic resonance.
Biochemical markers improve the classification and staging of breast cancer and may refine management decisions if it can be shown that they correlate with accepted prognostic factors or patient outcome. Using phosphorus-31 magnetic resonance spectroscopy ((31)P MRS), we determined the phospholipid content of 43 malignant breast tumors, correlating the profiles with specific histopathologic and clinical features and hormone receptor status. Among the 14 phospholipids identified, the mean mole percentage of sphingomyelin, phosphatidylcholine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, and alkylacylphosphatidylcholine predicted cellular infiltration, infiltration type, elastosis, lymphatic invasion, perineural invasion, necrosis, and estrogen receptor positivity. (31)P MRS phospholipid profile data provide statistical correlations among histologic features and molecules known to play important roles in cellular communication, regulation, and processes unique to malignant tissues.
Merchant
Thomas E
TE
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. thomas.merchant@stjude.org
Kasimos
John N
JN
Vroom
Thea
T
de Bree
Elco
E
Iwata
Jan Lei
JL
de Graaf
Peter W
PW
Glonek
Thomas
T
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D006098:Granulocytes / Q000378:metabolism; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015999:Multivariate Analysis; D009336:Necrosis; D010712:Phosphatidic Acids / Q000096:biosynthesis; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010715:Phosphatidylglycerols / Q000096:biosynthesis; D010718:Phosphatidylserines / Q000096:biosynthesis; D010743:Phospholipids / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D011960:Receptors, Estrogen / Q000096:biosynthesis; D013109:Sphingomyelins / Q000096:biosynthesis
D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010718:Phosphatidylserines; D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D011960:Receptors, Estrogen; D013109:Sphingomyelins