title: Secretory carcinoma of the breast: an immunohistochemical and ultrastructural study.
abstract: Abstract We report a rare case of secretory carcinoma of the breast in a 50-year-old Japanese woman. The patient had been aware of a right breast tumor for 8 years, but had left it untreated. The tumor enlarged in size and became painful, and she visited our hospital. Breast carcinoma was diagnosed, and mastectomy was performed. Histopathological examination revealed features of a secretory carcinoma characterized by prominent secretory activity in the glandular and microcystic spaces, with some areas showing a follicular pattern resembling the thyroid gland. The secretory material was PAS-positive and immunohistochemically alpha-lactalbumin-positive. Ultrastructurally, the tumor cell contained many secretory vacuoles in the cytoplasm. In addition, extracellular and intracytoplasmic lumina were conspicuous; these were lined by microvilli projection and contained secretory material. By flow cytometric analysis, the DNA index was 1.14, which was diploid, showing relatively low proliferative activity.
authors.affiliation: Clinical Laboratory, Juntendo University School of Medicine, Urayasu Hospital, 2-1-1 Tomioka, Urayasu 279-0021, Japan.
authors.forename: F.
authors.initials: F
authors.lastname: Suzuki
authors.forename: A.
authors.initials: A
authors.lastname: Saito
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Ishi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Okazaki
authors.forename: Katsunari
authors.initials: K
authors.lastname: Kina
authors.forename: Junichi
authors.initials: J
authors.lastname: Koyatsu
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Sugiyama