title: Preparative-scale synthesis of two metabolites isolated from soil treated with zoxium fungicide and kerb herbicide.
abstract: The preparation in multigram scale of two metabolites 3-(3,5-dichloro-4-methyl-benzoylamino)-2-hydroxy-3-methyl-pentanoic acid and 3-(3,5-dichloro-benzoylamino)-3-methyl-2-oxo-butyric acid isolated from soil treated with either Zoxium fungicide or Kerb herbicide was efficiently accomplished using a common 5-step synthetic process starting from easily available raw materials.
authors.affiliation: Rohm and Haas Company, 727 Norristown Road, Spring House, PA 19477-0904, USA. emichelotti@locusdiscovery.com
authors.forename: Enrique L
authors.initials: EL
authors.lastname: Michelotti
authors.forename: José I
authors.initials: JI
authors.lastname: Borrell
authors.forename: Renee
authors.initials: R
authors.lastname: Roemmele
authors.forename: Josep L
authors.initials: JL
authors.lastname: Matallana
authors.forename: Jordi
authors.initials: J
authors.lastname: Teixidó
authors.forename: Lois M
authors.initials: LM
authors.lastname: Bryman
mesh_terms: D000577:Amides / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D002087:Butyrates / Q000138:chemical synthesis*; D005659:Fungicides, Industrial / Q000737:chemistry*; D006540:Herbicides / Q000737:chemistry*; D010421:Pentanoic Acids / Q000138:chemical synthesis*; D012989:Soil Pollutants / Q000378:metabolism
chemical_list: D000577:Amides; D001549:Benzamides; D002087:Butyrates; D005659:Fungicides, Industrial; D006540:Herbicides; D010421:Pentanoic Acids; D012989:Soil Pollutants; C451427:zoxamide; C001059:pronamide