title: Improved subtraction by adiabatic FAIR perfusion imaging.
abstract: For pulsed arterial spin labeling techniques (e.g., FAIR), mismatches between the imaging and inversion slice profile result in a nonperfusion-related offset. Several methods have been proposed to reduce subtraction errors in FAIR imaging. Here an acquisition method for FAIR experiments based on adiabatic principles is proposed. It is shown that with adiabatic pulses the same pulse can be used for labeling and echo refocusing, thereby reducing the mismatch between imaging and labeling slice. A twofold reduction in subtraction errors compared to 5-lobe sinc excitation was shown both experimentally and by simulation.
authors.affiliation: Department of Experimental in vivo NMR, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands. janneke@invivonmr.uu.nl
authors.forename: Janneke
authors.initials: J
authors.lastname: Schepers
authors.forename: Michael
authors.initials: M
authors.lastname: Garwood
authors.forename: Boudewijn
authors.initials: B
authors.lastname: van der Sanden
authors.forename: Klaas
authors.initials: K
authors.lastname: Nicolay
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D019047:Phantoms, Imaging; D051381:Rats; D012039:Regional Blood Flow / Q000502:physiology; D012680:Sensitivity and Specificity; D013382:Subtraction Technique