[Relationship between circulating vascular cell adhesion molecule-1 and vascular complications in type 2 diabetes mellitus].
OBJECTIVE
To investigate the relationship between soluble vascular cell adhesion molecule-1 (sVCAM-1) and type 2 diabetes complicated with vascular diseases.


METHODS
In 61 cases of type 2 diabetes with macrovascular or microvascular complications and 36 cases of healthy control, sVCAM-1 levels were measured in duplicate by enzyme-linked immunosorbent assay using the soluble VCAM-1 Kit (R& D Systems Ltd, Ablingdon, Oxfordshire, UK).


RESULTS
sVCAM-1 levels in type 2 diabetes [(973.25 +/- 73.38) microg/L] were higher than these of healthy controls [(230.45 +/- 12.47) microg/L], P < 0.001. sVCAM-1 levels of type 2 diabetes with hypertension [(1263.99 +/- 87.00) microg/L] were higher than those of type 2 diabetes with microvascular complications [(726.57 +/- 95.40) microg/L], P < 0.001.


CONCLUSIONS
There was a significant correlation between sVCAM-1 concentration and vascular complications of type 2 diabetes.
Gu
W
W
Department of Endocrinology, The Second Affilliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, China.
Xu
X
X
Zhu
Y
Y
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D019010:Vascular Cell Adhesion Molecule-1