The effect of high doses of folic acid on the overexpression of ornithine decarboxylase and S-adenosylmethionine content in human colon adenomatous polyps.
It was shown that the 3-month supplementation of patients having colon polyps with folic acid (5 mg/day) led to a 35% decrease in abnormally high ornithine decarboxylase activity in polyps that was accompanied by a 43% increase of S-adenosylmethionine content in polyps.
Bukin YUV
Department of Epidemiology and Cancer Prevention, Russian Cancer Research Center, Moscow. buk@crc.umos.ru
Draudin-Krylenko
V A
VA
Levchuk
A A
AA
Poddubniy
B K
BK
Mazurov
S T
ST
D018256:Adenomatous Polyps / Q000201:enzymology / Q000378:metabolism*; D003111:Colonic Polyps / Q000201:enzymology / Q000378:metabolism*; D018450:Disease Progression; D004311:Double-Blind Method; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009955:Ornithine Decarboxylase / Q000096:biosynthesis* / Q000235:genetics; D012436:S-Adenosylmethionine / Q000378:metabolism*
D009363:Neoplasm Proteins; D012436:S-Adenosylmethionine; D005492:Folic Acid; D009955:Ornithine Decarboxylase