title: [Hormone replacement therapy reduces the risk of forearm fracture in postmenopausal women. Results of the Danish Osteoporosis Prevention Study].
abstract: In a prospective, controlled, comprehensive cohort trial of 2,016 healthy early postmenopausal women aged 45-58 years we studied fracture prevention through the use of oestrogen. There were two main study arms: a randomised arm (randomised to HRT [n = 502] or not [n = 504]) and a non-randomised arm (on HRT [n = 221] or not [n = 789] by own choice). After five years, an intention-to-treat analysis (n = 2,016) showed a reduction in the overall fracture risk (RR = 0.73, 95% CI: 0.50-1.05) and in the forearm fracture risk (RR = 0.45, 95% CI: 0.22-0.90) with oestrogen. Restriction of the analysis to women who had adhered to their initial allocation of either oestrogen (n = 395) or no oestrogen (n = 977) showed a significant reduction in both the overall fracture risk (RR = 0.61, 95% CI: 0.39-0.97) and the risk of forearm fractures (RR = 0.24, 95% CI: 0.09-0.69). We conclude that it is possible to reduce the number of forearm fractures in early postmenopausal women by the use of oestrogen as primary prevention.
authors.affiliation: Medicinsk afdeling C, Arhus Universitetshospital, Arhus Amtssygehus.
authors.forename: L
authors.initials: L
authors.lastname: Mosekilde
authors.forename: H
authors.initials: H
authors.lastname: Beck-Nielsen
authors.forename: O H
authors.initials: OH
authors.lastname: Sørensen
authors.forename: S P
authors.initials: SP
authors.lastname: Nielsen
authors.forename: P
authors.initials: P
authors.lastname: Charles
authors.forename: P
authors.initials: P
authors.lastname: Vestergaard
authors.forename: A P
authors.initials: AP
authors.lastname: Hermann
authors.forename: J
authors.initials: J
authors.lastname: Gram
authors.forename: T B
authors.initials: TB
authors.lastname: Hansen
authors.forename: B
authors.initials: B
authors.lastname: Abrahamsen
authors.forename: E N
authors.initials: EN
authors.lastname: Ebbesen
authors.forename: L S
authors.initials: LS
authors.lastname: Stilgren
authors.forename: L B
authors.initials: LB
authors.lastname: Jensen
authors.forename: C
authors.initials: C
authors.lastname: Brot
authors.forename: B
authors.initials: B
authors.lastname: Hansen
authors.forename: C L
authors.initials: CL
authors.lastname: Tofteng
authors.forename: P A
authors.initials: PA
authors.lastname: Eiken
authors.forename: N U
authors.initials: NU
authors.lastname: Kolthoff
mesh_terms: D000368:Aged; D015519:Bone Density; D015331:Cohort Studies; D015914:Estrogen Replacement Therapy; D005260:Female; D005543:Forearm Injuries / Q000209:etiology / Q000517:prevention & control*; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies