Synthesis of (R)-(+)-hippospongic acid A, a triterpene isolated from the marine sponge, Hippospongia sp.
Hippospongic acid A (1) is a triterpene metabolite of the marine sponge, Hippospongia sp., with inhibitory activity against the gastrulation of starfish embryos. (R)-(+)-1 was synthesized by employing enzymatic kinetic resolution as the key step.
Ichihashi
M
M
Department of Chemistry, Science University of Tokyo, Japan.
Takikawa
H
H
Mori
K
K
D000818:Animals; D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D005775:Gastrula / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000378:metabolism*; D013215:Starfish / Q000187:drug effects / Q000196:embryology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
D002264:Carboxylic Acids; D014315:Triterpenes; C459583:hippospongic acid A