title: Use of morphine and adjuvant drugs according to the condition.
abstract: Adjuvant drugs are used to enhance effects of analgesics and morphine-resistant pain such as neuropathic pain. If morphine provides inadequate pain relief and evokes drowsiness, morphine is usually ineffective. The key is the patient's reaction to morphine. When a patient's pain includes neuropathic pain, a combination of morphine and non-steroidal anti-inflammatory drugs is partially effective, but morphine-resistant pain remains. Increasing morphine dosage causes drowsiness without pain improvement. Appropriate adjuvant drugs are necessary in these conditions.
authors.affiliation: Kitasato University School of Medicine, Department of Anesthesiology, Kitasato Sagamihara City, Kanagawa, Japan. nopain@med.kitasato-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Matoba
mesh_terms: D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D009020:Morphine / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D000928:Antidepressive Agents; D009020:Morphine