title: [Changes of transmembrane ion transport in essential hypertensives with familial histories].
abstract: OBJECTIVE
  To investigate the effects of heredity on transmembrane ion transport in essential hypertension (EH).
  
  
  METHODS
  52 essential hypertensives were divided into two groups, 23 with positive family history (FH(+)) and 29 with negative family history (FH(-)). The rate constant of ouabain-sensitive sodium efflux ((o)K(os)) was measured as the half of the increase in erythrocyte Na(+) concentration during incubation with ouabain for 2 hours, (o)K(os) was calculated by an equation and the maximal rate (Vmax) of red cells Na(+)/H(+) exchange was determined as the Na(+) influx promoted by an outward H(+) gradient. Intracellular Na(+) concentration was measured with flame photometry and (45)Ca(2+) influx in ATP-depleted red cells with liquid scintillation counting.
  
  
  RESULTS
  The red cell Na(+)/H(+) exchange and (45)Ca(2+) in-flux were significantly higher but the (o)K(os) lower in both the FH(+) and FH(-) groups than in the controls. FH(+) group demonstrated a significantly higher (o)K(os) and lower Ca(2+) influx as compared with those in FH(-) group. In FH(+) group, systolic blood pressure was positively correlated with age, while diastolic blood pressure positively correlated with (45)Ca(2+) influx.
  
  
  CONCLUSIONS
  Our data show a genetic contribution to abnormal membrane transport in hypertension. There is a defect in membrane permeability to Ca(2+) and a greater exchangeable pool of cytosolic free Ca(2+) in FH(+) group that participate in the pathogenesis of inherited hypertension.
authors.affiliation: Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing 400042.
authors.forename: J
authors.initials: J
authors.lastname: Tan
authors.forename: Z
authors.initials: Z
authors.lastname: Zhu
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Zhu
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000368:Aged; D002118:Calcium / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D017136:Ion Transport; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood
chemical_list: D012964:Sodium; D002118:Calcium