title: Berberis crataegina DC. root exhibits potent anti-inflammatory, analgesic and febrifuge effects in mice and rats.
abstract: Extracts obtained from the roots and barks of various Berberis species are used as folk remedy worldwide for the treatment of various inflammatory ailments including lumbago, rheumatism and to reduce fever. Effects of the extracts and fractions from the roots of Berberis crataegina DC. (Berberidaceae) were studied using various in vivo models of inflammation in mice and rats and observed potent inhibitory activity against carrageenan- and serotonin-induced hind paw oedema, acetic acid-induced increased vascular permeability, castor oil-induced diarrhoea, and Freund's complete adjuvant-induced (FCA) arthritis models. Through bioassay-guided fractionation berberine was isolated as the main active ingredient. Moreover, a dose-dependent analgesic activity was determined, which assessed by using the model based on the inhibition of acetic acid-induced writhing reflexes, as well as antipyretic activity on FCA-induced increased body temperature. Acute and subchronic toxicity studies were also performed.
authors.affiliation: Gazi University, Faculty of Pharmacy, Etiler 06330, Ankara, Turkey. yesilada@pharmacy.gazi.edu.tr
authors.forename: Erdem
authors.initials: E
authors.lastname: Yeşilada
authors.forename: Esra
authors.initials: E
authors.lastname: Küpeli
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D001599:Berberine / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D028142:Berberis; D003967:Diarrhea / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D004487:Edema / Q000188:drug therapy; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects / Q000706:statistics & numerical data; D008517:Phytotherapy / Q000379:methods / Q000706:statistics & numerical data; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D001599:Berberine