Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production.
Two new sesquiterpene esters, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran (1) and 1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran (2), together with four known sesquiterpene esters (3-6), celastrol (7), and celaphanol A (8) were isolated from the roots of Celastrus orbiculatus in a search for inhibitors of NF-kappaB activation and nitric oxide production. Compound 7 was the most active, while compounds 1, 2, 4, and 8 showed moderate inhibition in both NF-kappaB activation and nitric oxide production.
Jin
Hui Zi
HZ
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
Hwang
Bang Yeon
BY
Kim
Hang Sub
HS
Lee
Jeong Hyung
JH
Kim
Young Ho
YH
Lee
Jung Joon
JJ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029753:Celastraceae / Q000737:chemistry*; D002478:Cells, Cultured / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D007723:Korea; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010957:Plasmids / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C449856:1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran; C449858:1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D016328:NF-kappa B; D012717:Sesquiterpenes; C449857:celaphanol A; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase