title: Early lung cancer action project: annual screening using single-slice helical CT.
abstract: The advent of helical CT imaging held promise for the early diagnosis, and thereby, for enhanced curability of lung cancer--a highly fatal disease. In 1993, the Early Lung Cancer Action Project (ELCAP) was initiated and experimentally screened a cohort of 1,000 high-risk persons. Here we summarize the results of the baseline and annual repeat CT screening of these 1,000 subjects. CT-based screening (compared to traditional radiology) was clearly shown to enhance the detection of lung cancer at earlier and more curable stages. A discussion follows of the meaning of the results and possible future screening protocols.
authors.affiliation: Department of Radiology, Weill Medical College of Cornell University, New York, New York 10021, USA.
authors.forename: C I
authors.initials: CI
authors.lastname: Henschke
authors.forename: D F
authors.initials: DF
authors.lastname: Yankelevitz
authors.forename: D M
authors.initials: DM
authors.lastname: Libby
authors.forename: D
authors.initials: D
authors.lastname: McCauley
authors.forename: M
authors.initials: M
authors.lastname: Pasmantier
authors.forename: N K
authors.initials: NK
authors.lastname: Altorki
authors.forename: J P
authors.initials: JP
authors.lastname: Smith
authors.forename: O S
authors.initials: OS
authors.lastname: Miettinen
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005544:Forecasting; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D008403:Mass Screening / Q000379:methods* / Q000706:statistics & numerical data; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D010352:Patient Dropouts; D015397:Program Evaluation; D012907:Smoking; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D014057:Tomography, X-Ray Computed / Q000379:methods*