Multilocus linkage analysis of the German asthma data.
We analyzed data from the German Asthma Genetics Group with three methods that utilize pedigree-specific nonparametric linkage scores to facilitate the search for multiple independent and interacting susceptibility loci. The three methods included a conditional analysis, logistic regression, and neural networks. Although there were differences, the three methods identified many of the same susceptibility loci. The most consistent evidence was provided for loci on chromosomes 1, 2, 6, 9, and 15. Both the conditional and the logistic regression analyses suggested an epistatic relationship between loci on chromosomes 2 and 9. The logistic regression analysis further revealed evidence for locus heterogeneity between loci on chromosomes 6 and 15. Finally, the neural network analysis identified a potential locus on chromosome 17 that was not identified in the other analyses.
Zandi
P P
PP
Department of Mental Hygiene, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
Klein
A P
AP
Addington
A M
AM
Hetmanski
J B
JB
Roberts
L
L
Peila
R
R
Shrestha
S
S
Shaw
C K
CK
Kiat
H C
HC
Langefeld
C D
CD
Beaty
T H
TH
D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002884:Chromosomes, Human, Pair 15; D002885:Chromosomes, Human, Pair 16; D002889:Chromosomes, Human, Pair 2; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D004843:Epistasis, Genetic; D005260:Female; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005828:Genetics, Population; D005858:Germany; D006801:Humans; D008297:Male; D016571:Neural Networks, Computer; D018709:Statistics, Nonparametric