title: Decreased lung function associated with perinatal exposure to Dutch background levels of dioxins.
abstract: Perinatal exposure to Dutch background dioxin levels is rather high. Studies of calamities have shown that dioxins negatively influence the respiratory system. It was hypothesized that perinatal exposure to background dioxin levels leads to lung suboptimality, probably through developmental interference. This study aimed to assess lung function in relation to perinatal dioxin exposure. Spirometry was performed in 41 healthy children (aged 7-12 y. mean 8.2 y) with known perinatal dioxin exposure. The ratio of forced expiratory volume in I s to forced vital capacity (FEV1/FVC ratio) was determined. A complete medical history was taken. The prenatal exposure ranged from 8.74 to 88.8 (mean 34.6) ng TEQ dioxin kg fat(-1), measured in breast milk. The postnatal exposure ranged from 4.34 to 384.51 (mean 75.4) ng TEQ dioxin. Twelve children had to be excluded. A significant decrease in lung function in relation to both prenatal (p = 0.045) and postnatal (p = 0.0002) dioxin exposure was seen in the 29 non-excluded children. A clinical association between chest congestion and perinatal dioxin exposure was seen.
  
  
  CONCLUSIONS
  Perinatal background dioxin exposure may be inversely associated with the FEV1/ FVC ratio.
authors.affiliation: Department of Paediatrics and Neonatology, Emma Children's Hospital/Academic Medical Centre, Amsterdam, The Netherlands. g.w.ten.tusscher@wxs.nl
authors.forename: G W
authors.initials: GW
authors.lastname: ten Tusscher
authors.forename: J
authors.initials: J
authors.lastname: de Weerdt
authors.forename: C M
authors.initials: CM
authors.lastname: Roos
authors.forename: R W
authors.initials: RW
authors.lastname: Griffioen
authors.forename: F H
authors.initials: FH
authors.lastname: De Jongh
authors.forename: M
authors.initials: M
authors.lastname: Westra
authors.forename: J W
authors.initials: JW
authors.lastname: van der Slikke
authors.forename: J
authors.initials: J
authors.lastname: Oosting
authors.forename: K
authors.initials: K
authors.lastname: Olie
authors.forename: J G
authors.initials: JG
authors.lastname: Koppe
mesh_terms: D000328:Adult; D002648:Child; D004147:Dioxins / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016014:Linear Models; D008171:Lung Diseases / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D015656:Respiratory Mechanics; D012307:Risk Factors; D013147:Spirometry
chemical_list: D004147:Dioxins