Pediatric acute hemorrhagic leukoencephalitis: report of a surviving patient and review.
Acute hemorrhagic leukoencephalitis (AHLE) is a rare, fulminant CNS demyelinating condition usually diagnosed at autopsy. We report the clinical, laboratory, radiographic, and pathologic features of the first nonfatal case of pediatric AHLE confirmed by brain biopsy. Pathologic diagnosis of this condition may be critical to exclude more-common processes and to expedite the decision to administer high-dose corticosteroid therapy, which is potentially lifesaving.
Leake
John A D
JA
Division of Infectious Diseases, Children's Hospital and Health Center, San Diego, CA, 92123, USA. jleake@chsd.org
Billman
Glenn F
GF
Nespeca
Mark P
MP
Duthie
Susan E
SE
Dory
Christopher E
CE
Meltzer
Hal S
HS
Bradley
John S
JS
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000188:drug therapy / Q000503:physiopathology*
D000893:Anti-Inflammatory Agents