Generalized hyperpigmentation with daunorubicin chemotherapy.
Daunorubicin has been reported to cause hyperpigmentation of sun-exposed skin and/or transverse nail pigmentation (3 cases). We report a case of an African American man who had an atypical pattern of generalized hyperpigmentation develop that involved many sun-protected skin areas 2 weeks after daunorubicin treatment. Histopathology of hyperpigmented skin showed increased melanin granules in all epidermal layers. The mechanisms by which daunorubicin may increase skin pigmentation are discussed.
Kroumpouzos
George
G
Department of Dermatology, Boston Medical Center, Boston University School of Medicine, MA, USA. kroumpouzos.george@boston.va.gov
Travers
Robin
R
Allan
Anne
A
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D044383:Black People; D003630:Daunorubicin / Q000009:adverse effects*; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008297:Male; D001741:Black or African American
D000903:Antibiotics, Antineoplastic; D003630:Daunorubicin