[Advance in the research of endostatin].
Endostatin was a newly found N-terminal fragment of collagen XVIII NC1 domain, which has distinct anti-angiogenesis character. Its prominent anti-tumor effect in mouse model made its a hot point of research and a promising anti-tumor drug candidate. This article will give some discussion in this field.
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Beijing Institute of Biotechnology, Key Lab. of Molecule Genetics, Beijing 100850, China. fefeicat@mailcity.com
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D000818:Animals; D003094:Collagen / Q000737:chemistry* / Q000494:pharmacology*; D043170:Collagen Type XVIII; D043169:Endostatins; D006801:Humans; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology*; D012106:Research
D043170:Collagen Type XVIII; D043169:Endostatins; D010446:Peptide Fragments; D003094:Collagen