[Clinical study on lixin pill in treating congestive heart failure].
OBJECTIVE
To observe the clinical therapeutic effect of Lixin Pill (LXP) in treating patients with congestive heart failure (CHF).


METHODS
Ninety CHF patients with heart function of III-IV grade were randomly divided into 3 groups. Group A was treated with LXP, Group B with LXP plus small dosage of digoxin and Group C with ordinary dosage of digoxin. The therapeutic course for all the three groups was 1 month. Meanwhile, all patients were given ordinary dosage of diuretics, nitrates and angiotensin-converting enzyme inhibitors (ACEI) as basic therapy.


RESULTS
The total effective rate in improving heart function in Group A, B and C was 83.3%, 93.3% and 90.0% respectively. In respect of improving myocardial contraction and dilation, the left ventricular ejection fraction (LVEF) was improved in all the three groups but was more superior in Group B (P < 0.05); the ratio of maximum blood flow between the advanced and the early diastolic stage (A/E) was improved, and the complicated supraventricular and ventricular premature contraction in Group A and B were reduced markedly after treatment (P < 0.01 or P < 0.05), and the effect in Group B was superior to that in Group A.


CONCLUSIONS
Using LXP combined with small dosage of digoxin could improve the therapeutic effect in treating patients suffering from congestive heart failure.
Li
L
L
Research Division of Cardiovascular Diseases, Xiyuan Hospital, China Academy of TCM, Beijing (100091).
Zhang
J
J
Xu
F
F
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D003327:Coronary Disease / Q000150:complications; D004231:Diuresis; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged
D000806:Angiotensin-Converting Enzyme Inhibitors; D004365:Drugs, Chinese Herbal