In vivo examination of lentigo maligna and malignant melanoma in situ, lentigo maligna type by near-infrared reflectance confocal microscopy: comparison of in vivo confocal images with histologic sections.
In vivo confocal microscopy can noninvasively image thin en face sections within living intact human tissue with high resolution and contrast. This evolving technique may provide clinicians with tools to help detect lentigo maligna lesion progression in vivo and may be important in defining tumor margins, thus providing a more definitive surgical eradication of lentigo maligna and malignant melanoma in situ, lentigo maligna type. We present a case of malignant melanoma in situ, lentigo maligna type, and we describe the images seen with confocal microscopy in correlation with routine histopathology.
Tannous
Zeina S
ZS
Dermatopathology Unit, Pathology Department, Massachusetts General Hospital, Boston, MA, USA.
Mihm
Martin C
MC
Flotte
Thomas J
TJ
González
Salvador
S
D000368:Aged; D001707:Biopsy, Needle; D002278:Carcinoma in Situ / Q000473:pathology* / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000473:pathology* / Q000601:surgery; D007150:Immunohistochemistry; D008545:Melanoma / Q000473:pathology* / Q000648:ultrastructure; D018613:Microscopy, Confocal; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery