Epigenetic reprogramming: how now, cloned cow?
DNA methylation patterns are dynamic in cleavage-stage embryos of a number of mammalian species. A failure to properly recapitulate preimplantation DNA methylation patterns in embryos derived by nuclear transfer may contribute to the low efficiency of nuclear transfer in producing live offspring.
Fairburn
Hannah R
HR
Division of Gene Expression and Development, Roslin Institute, EH25 9PS, Roslin, UK.
Young
Lorraine E
LE
Hendrich
Brian D
BD
D000818:Animals; D002417:Cattle; D019976:Cloning, Organism; D019175:DNA Methylation; D004622:Embryo, Mammalian / Q000378:metabolism; D005314:Embryonic and Fetal Development