title: Conscious sedation by oral administration of midazolam in paediatric dental treatment.
abstract: Midazolam is a short-acting benzodiazepine with rapid onset, short duration of action and minimal side effects. The aim of this study was to evaluate the oral administration of midazolam as pre-operative sedation in the dental treatment of uncooperative pediatric patients. Included in the study were 160 children with a mean age of 6.7 +/- 2.6 years (1-14 years), 83 boys and 77 girls. All the patients had been referred for specialist treatment due to behavioral management problems. Treatment was performed in 250 sessions. All the children received an oral dose of 0.2 mg/kg body weight of midazolam. Acceptance of treatment was evaluated according to Rud & Kisling. Local anesthesia followed by restorative treatment and/or extractions constituted more than 90% of the performed treatments. Of the 250 sessions, 63% were performed with total acceptance and 30% with doubtful acceptance. In 7%, no treatment could be performed. No serious complications were registered during or after treatment. All the children were able to leave the clinic one hour after treatment. In conclusion, we consider oral administration of midazolam a safe form of premedication. The route of administration, the short waiting-time and half-life, in combination with a level of sedation that allows treatment to be performed, are the principal advantages of conscious sedation with orally administered midazolam.
authors.affiliation: Department of Odontology/Pedodontics, Umeä University, Sweden. anna-lena.erlandsson@nll.se
authors.forename: A L
authors.initials: AL
authors.lastname: Erlandsson
authors.forename: B
authors.initials: B
authors.lastname: Bäckman
authors.forename: A
authors.initials: A
authors.lastname: Stenström
authors.forename: C
authors.initials: C
authors.lastname: Stecksén-Blicks
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000294:Adolescent Behavior / Q000187:drug effects; D000766:Anesthesia, Dental / Q000379:methods*; D000772:Anesthesia, Local; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002648:Child; D002652:Child Behavior / Q000187:drug effects; D002675:Child, Preschool; D016292:Procedural Sedation / Q000379:methods*; D003299:Cooperative Behavior; D016854:Dental Anxiety / Q000517:prevention & control; D003793:Dental Restoration, Permanent; D003812:Dentist-Patient Relations; D004644:Emotions / Q000187:drug effects; D005260:Female; D006207:Half-Life; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007223:Infant; D008297:Male; D008874:Midazolam / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013997:Time Factors; D014081:Tooth Extraction; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D008874:Midazolam