title: Spatial distribution of ventilation and perfusion in anesthetized dogs in lateral postures.
abstract: We aimed to assess the influence of lateral decubitus postures and positive end-expiratory pressure (PEEP) on the regional distribution of ventilation and perfusion. We measured regional ventilation (VA) and regional blood flow (Q) in six anesthetized, mechanically ventilated dogs in the left (LLD) and right lateral decubitus (RLD) postures with and without 10 cmH(2)O PEEP. Q was measured by use of intravenously injected 15-microm fluorescent microspheres, and VA was measured by aerosolized 1-microm fluorescent microspheres. Fluorescence was analyzed in lung pieces approximately 1.7 cm(3) in volume. Multiple linear regression analysis was used to evaluate three-dimensional spatial gradients of Q, VA, the ratio VA/Q, and regional PO(2) (Pr(O(2))) in both lungs. In the LLD posture, a gravity-dependent vertical gradient in Q was observed in both lungs in conjunction with a reduced blood flow and Pr(O(2)) to the dependent left lung. Change from the LLD to the RLD or 10 cmH(2)O PEEP increased local VA/Q and Pr(O(2)) in the left lung and minimized any role of hypoxia. The greatest reduction in individual lung volume occurred to the left lung in the LLD posture. We conclude that lung distortion caused by the weight of the heart and abdomen is greater in the LLD posture and influences both Q and VA, and ultimately gas exchange. In this respect, the smaller left lung was the most susceptible to impaired gas exchange in the LLD posture.
authors.affiliation: Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Hung
authors.initials: H
authors.lastname: Chang
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lai-Fook
authors.forename: Karen B
authors.initials: KB
authors.lastname: Domino
authors.forename: Carmel
authors.initials: C
authors.lastname: Schimmel
authors.forename: Jack
authors.initials: J
authors.lastname: Hildebrandt
authors.forename: H Thomas
authors.initials: HT
authors.lastname: Robertson
authors.forename: Robb W
authors.initials: RW
authors.lastname: Glenny
authors.forename: Michael P
authors.initials: MP
authors.lastname: Hlastala
mesh_terms: D000336:Aerosols; D000818:Animals; D004285:Dogs; D005260:Female; D005453:Fluorescence; D007275:Injections, Intravenous; D008168:Lung / Q000502:physiology; D008297:Male; D008863:Microspheres; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011175:Positive-Pressure Respiration; D011187:Posture / Q000502:physiology*; D011652:Pulmonary Circulation; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial; D014692:Ventilation-Perfusion Ratio
chemical_list: D000336:Aerosols; D010100:Oxygen