title: The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats.
abstract: Garcinia cambogia extract is a herbal preparation that has been suggested as useful in the treatment of gastrointestinal disorders. In the present study this drug was tested for its antiulcerogenic effect. Oral pretreatment with Garcinia cambogia fruit extract (1 g/kg body wt/day) for 5, 10 or 15 days protected the gastric mucosa against the damage induced by indomethacin (20 mg/kg body wt). The volume and acidity of the gastric juice decreased in the pretreated rats. The glycoprotein levels of the gastric contents which were decreased in the untreated rats, maintained near normal levels in the pretreated rats. Protein which was elevated in the gastric juice of untreated rats, showed near normal levels in the pretreated rats. Garcinia cambogia was able to decrease the acidity and to increase the mucosal defence in the gastric areas, thereby justifying its use as an antiulcerogenic agent.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India.
authors.forename: P
authors.initials: P
authors.lastname: Mahendran
authors.forename: A J
authors.initials: AJ
authors.lastname: Vanisree
authors.forename: C S
authors.initials: CS
authors.lastname: Shyamala Devi
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005638:Fruit / Q000737:chemistry; D029761:Garcinia cambogia; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects; D006023:Glycoproteins / Q000378:metabolism; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000897:Anti-Ulcer Agents; D006023:Glycoproteins; D010936:Plant Extracts; D011506:Proteins; D007213:Indomethacin