title: Use of electron microscopic evaluation for the diagnosis of adrenal cortical carcinoma in fine needle aspiration cytology: a case report and review of the literature.
abstract: Bilateral adrenal tumors were detected in a 72-year-old man who had a history of hepatic inflammatory pseudotumor. Computet tomography (CT)-guided fine needle aspiration cytology (FNAC) of the adrenal glands was performed. The cytologic findings were similar to the previous diagnosis of "inflammatory pseudotumor" in the liver. However, the origin of some aggregated large atypical cells observed in the adrenal FNAC specimens was not known. Immunocytochemically, these large atypical cells were positive for vimentin and negative for cytokeratin and chromogranin A. An electron-microscopic study showed that these large atypical cells contained mitochondria with tubulovesicular cristae and smooth endoplasmic reticulum arranged in whorled and laminated patterns, and these findings confirmed diagnosis of primary adrenal cortical carcinoma. The histopathological diagnosis of the resected bilateral adrenal tumor was adrenal cortical carcinoma. The patient died 7 months after surgery, with recurrence of the bilateral adrenal cortical carcinoma and extensive metastases. A diagnosis of primary adrenal cortical carcinoma with extensive metastases was finally demonstrated by autopsy. Retrospectively, the previous liver tumor was determined to be a metastatic lesion.
authors.affiliation: Central Institute for Electron Microscopic Research, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan. Liu_Aimin/emlab@nms.ac.jp
authors.forename: A M
authors.initials: AM
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Hosone
authors.forename: K
authors.initials: K
authors.lastname: Azuma
authors.forename: H
authors.initials: H
authors.lastname: Katayama
authors.forename: M
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Z
authors.initials: Z
authors.lastname: Naito
authors.forename: Y
authors.initials: Y
authors.lastname: Sugisaki
authors.forename: G
authors.initials: G
authors.lastname: Asano
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000648:ultrastructure; D018268:Adrenocortical Carcinoma / Q000175:diagnosis* / Q000648:ultrastructure; D000368:Aged; D001707:Biopsy, Needle; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron