Binding of aminoglycoside antibiotics with modified A-site 16S rRNA construct containing non-nucleotide linkers.
The design and synthesis of synthetically modified cyclic A-site 16S rRNA construct is reported. The binding characteristics of several members of the aminoglycoside antibiotics with this novel class of synthetically modified A-site 16S rRNA constructs were subsequently investigated.
Tok
Jeffrey B-H
JB
Department of Chemistry & Natural Sciences, York College and Graduate Center of the City University of New York, 94-20 Guy R. Brewer Blvd., Jamaica, NY 11451, USA. tok@york.cuny.edu
Wong
Wilson
W
Baboolal
Nyla
N
D000617:Aminoglycosides; D016880:Anisotropy; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D020029:Base Pairing; D001665:Binding Sites; D003500:Cyclization; D015195:Drug Design; D007202:Indicators and Reagents; D007700:Kinetics; D009690:Nucleic Acid Conformation; D018075:RNA, Complementary / Q000187:drug effects; D012336:RNA, Ribosomal, 16S / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D018075:RNA, Complementary; D012336:RNA, Ribosomal, 16S