title: Incidence of Helicobacter pylori in patients with interstitial cystitis.
abstract: OBJECTIVE
  Chronic gastritis has compelling similarities to interstitial cystitis (IC). It is characterised by chronic pain in a tubular organ. Histologically, epithelial damage, inflammatory response in the lamina propria and epithelial ulcerations are seen. An infective cause was rarely considered until the emergence of Helicobacter pylori over the past 15 years. We have had experience of patients with bladder pain and irritability reporting improvement with antihistamines. It has also been reported that IC symptoms improved dramatically after treatment for H. pylori infection. Previous studies have determined the incidence of H. pylori antibodies in women with IC but we examined bladder material histologically and performed the Campylobacter-like organism (CLO) test on the biopsy specimens.
  
  
  METHODS
  A prospective controlled study was performed. Patients with urinary symptoms fulfilling the National Institute of Diabetes and Digestive and Kidney Diseases criteria for IC underwent GA cystoscopy at which the macroscopic appearance of the bladder was noted and biopsies were taken. The biopsy material underwent histological examination and CLO test. Control patients who were undergoing cystoscopy for reasons other than investigation of IC also had biopsy taken and the CLO test was performed on these specimens.
  
  
  RESULTS
  Five of 15 patients with symptoms and signs of IC had a positive CLO test. Three of 15 patients of the control group had a positive CLO test. With the 2-sided chi(2) test there was no statistical difference between the 2 groups.
  
  
  CONCLUSIONS
  Our small prospective control study does not support the hypothesis that H. pylori is an important component in the pathogenesis of interstitial cystitis.
authors.affiliation: Department of Urology, Edith Cavell Hospital, Peterborough, UK. a.haq@doctors.org.uk
authors.forename: A
authors.initials: A
authors.lastname: Haq
authors.forename: S
authors.initials: S
authors.lastname: Mattocks
authors.forename: L
authors.initials: L
authors.lastname: Wong
authors.forename: P
authors.initials: P
authors.lastname: Dasgupta
authors.forename: C
authors.initials: C
authors.lastname: Dawson
authors.forename: H N
authors.initials: HN
authors.lastname: Blackford
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: A G
authors.initials: AG
authors.lastname: Turner
mesh_terms: D018856:Cystitis, Interstitial / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014510:Urease / Q000032:analysis*
chemical_list: D014510:Urease