[Osteoporosis in the man].
Osteoporosis in men is a severe condition probably more frequent than generally expected. The life-time risk of a low trauma fracture in a 60 year old man is 25%; moreover, approximately one third of hip fractures occurs in men. In contrast to postmenopausal osteoporosis, osteoporosis in men is frequently a secondary condition. In approximately 50% of cases, male osteoporosis is associated with an underlying disease or condition such as hypogonadism or long-term glucocorticoid treatment. Data from our group indicate that low serum estradiol levels and elevated sex hormone binding globulin levels may play a role in the pathogenesis of idiopathic male osteoporosis. Potential treatment modalities of osteoporosis in men include calcium and vitamin D supplementation, testosterone, fluoride, bisphophonates, calcitonin and parathyroid hormone. Currently, the data available favor the use of an aminobisphosphonate for the treatment of (idiopathic or glucocorticoid induced) osteoporosis.
Resch
H
H
II. Medizinische Abteilung, Krankenhaus der Barmherzigen Schwestern, Stumpergasse 13, A-1060 Wien. med2.wien@bhs.at
Gollob
E
E
Kudlacek
S
S
Pietschmann
P
P
D000368:Aged; D001317:Austria / Q000453:epidemiology; D004958:Estradiol / Q000097:blood; D005598:Fractures, Spontaneous / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007006:Hypogonadism / Q000150:complications; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D011379:Prognosis; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
D005938:Glucocorticoids; D012738:Sex Hormone-Binding Globulin; D004958:Estradiol