title: Cranial Doppler ultrasonography as a predictor of neurologic sequelae in infants with bacterial meningitis.
abstract: OBJECTIVE
  To perform transcranial Doppler sonography in newborns and infants with bacterial meningitis to evaluate predictive value of neurologic sequelae.
  
  
  METHODS
  Thirty-three patients (15 newborn, 18 infant patients) with bacterial meningitis underwent cranial Doppler ultrasonography during acute phase and 3rd and 6th months after disease. Patients were examined regularly for neurologic outcome with electroencephalography and magnetic resonance imaging. The age-matched control group consisted of 20 healthy children underwent cranial Doppler sonography only.
  
  
  RESULTS
  To compare with the healthy controls, the mean blood flow velocity was significantly increased (P < 0.001), and pulsatility index was higher than those control group (P < 0.05) during acute bacterial meningitis. None of the patients were diagnosed with stenosis of cerebral artery. According to neurologic outcome, 14 of 33 patients had neurologic sequelae. The mean cerebral blood flow was significantly higher (P < 0.01) in patients without neurologic sequelae; pulsatility index was significantly higher (P < 0.05) in patients with neurologic sequelae when compared with the healthy controls. There was no significant difference between mean cerebral blood flow velocities and mean pulsatility index values of newborn and infant patients, regarding to neurologic outcome (P < 0.05).
  
  
  CONCLUSIONS
  Cranial Doppler ultrasonography is useful for prediction of neurologic sequelae in infants with bacterial meningitis.
authors.affiliation: Department of Pediatrics, KTU Medical Faculty, Trabzon, Turkey. aokten@meds.ktu.edu.tr
authors.forename: A
authors.initials: A
authors.lastname: Okten
authors.forename: A
authors.initials: A
authors.lastname: Ahmetoğlu
authors.forename: E
authors.initials: E
authors.lastname: Dilber
authors.forename: H
authors.initials: H
authors.lastname: Dinc
authors.forename: M
authors.initials: M
authors.lastname: Kalyoncu
authors.forename: K
authors.initials: K
authors.lastname: Ciftçibaiş
authors.forename: N
authors.initials: N
authors.lastname: Yariş
mesh_terms: D001783:Blood Flow Velocity; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications* / Q000000981:diagnostic imaging; D009422:Nervous System Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011673:Pulsatile Flow; D017585:Ultrasonography, Doppler, Transcranial