title: Physical, chemical, and biological properties of s-allylcysteine, an amino acid derived from garlic.
abstract: Physical, chemical, and biological properties of S-allylcysteine (SAC) were investigated. SAC showed stable properties under tested conditions, and its acute/subacute toxicity was very minor in mice and rats (LD(50) value >54.7 mM/kg po; >20 mM/kg ip). The pharmacokinetics of SAC was investigated after oral administration of garlic supplement containing SAC to human volunteers. SAC from garlic consumption was rapidly absorbed from the gastrointestinal tract, however, the half-life and excretion time were more than 10 h and 30 h, respectively.
authors.affiliation: Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd., 1624 shimokoutachi, Koda-cho, Takata-gun, Hiroshima 729-1195, Japan. kodera_y@wakunaga.co.jp
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Kodera
authors.forename: Ayumi
authors.initials: A
authors.lastname: Suzuki
authors.forename: Osamu
authors.initials: O
authors.lastname: Imada
authors.forename: Shigeo
authors.initials: S
authors.lastname: Kasuga
authors.forename: Isao
authors.initials: I
authors.lastname: Sumioka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kanezawa
authors.forename: Nobuo
authors.initials: N
authors.lastname: Taru
authors.forename: Masanori
authors.initials: M
authors.lastname: Fujikawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagae
authors.forename: Koji
authors.initials: K
authors.lastname: Masamoto
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Maeshige
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Ono
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity*; D005260:Female; D005737:Garlic / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests
chemical_list: C065299:S-allylcysteine; D003545:Cysteine