Protein aggregates and dementia: is there a common toxicity?
This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in neurodegenerative dementing disorders. It concentrates on the two most obvious candidates for the role of toxic protein in Alzheimer's disease (AD)--beta-amyloid peptide and tau--but also considers other proteins in this disorder and in less common but equally devastating diseases.
Lovestone
S
S
Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. s.lovestone@iop.kcl.ac.uk
McLoughlin
D M
DM
D000544:Alzheimer Disease / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism; D001921:Brain / Q000473:pathology; D005110:Extracellular Space; D006801:Humans; D000071058:Huntingtin Protein; D002479:Inclusion Bodies / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000473:pathology*; D009687:Nuclear Proteins / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D011328:Prions / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D051843:Synucleins; D016875:tau Proteins / Q000378:metabolism
D000682:Amyloid; C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D010446:Peptide Fragments; D011328:Prions; D011506:Proteins; D051843:Synucleins; D016875:tau Proteins