The role of chemokines in linking innate and adaptive immunity.
It is becoming clear that chemokine function is necessary to translate an innate-immune response into an acquired response. Dendritic cells activated by innate stimuli and loaded with foreign antigen travel to regional lymph nodes to activate the acquired-immune system. Subsequently, the activated acquired-immune cells move into tissue, where the innate immune system sets-off the danger signal. The chemokine system has emerged as an essential regulator of this dendritic cell and lymphocyte trafficking, which is necessary to turn an innate immune response into an adaptive response.
Luster
Andrew D
AD
Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA. luster@helix.mgh.harvard.edu
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002450:Cell Communication / Q000276:immunology; D018925:Chemokines / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D013601:T-Lymphocytes / Q000276:immunology
D018925:Chemokines