Alginate/chitosan particulate systems for sodium diclofenac release.
Alginate/chitosan particles were prepared by ionic gelation (Ca2+ and Al3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed.
González-Rodríguez
M L
ML
Departamento de Farmacia y Tecnología Farmacacéutica, Facultad de Farmacia, C/Profesor Garcia Gonzalez s/n, Universidad de Sevilla, 41012, Sevilla, Spain. rabasco@fafar.us.es
Holgado
M A
MA
Sánchez-Lafuente
C
C
Rabasco
A M
AM
Fini
A
A
D000464:Alginates / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D002686:Chitin / Q000031:analogs & derivatives / Q000737:chemistry; D048271:Chitosan; D004008:Diclofenac / Q000737:chemistry*; D004337:Drug Carriers; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006863:Hydrogen-Ion Concentration; D008863:Microspheres
D000464:Alginates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D006603:Hexuronic Acids; D002686:Chitin; D004008:Diclofenac; D020723:Glucuronic Acid; D048271:Chitosan