title: Hypercalcemia due to latrogenic secondary hypoadrenocorticism and diabetes mellitus in a cat.
abstract: A 9-year-old, spayed female domestic shorthair cat presented for polyphagia, polydipsia, and polyuria following chronic methylprednisolone acetate therapy for pruritus. Initial diagnostics were consistent with uncomplicated diabetes mellitus. Serum calcium was within reference range. Within 12 hours the cat developed depression, anorexia, vomiting, and severe dehydration. Laboratory analysis indicated marked hypercalcemia as measured by both ionized and total calcium concentration. No underlying neoplastic or inflammatory process was identified. An adrenocorticotropic hormone stimulation test was indicative of adrenocortical insufficiency. The hypercalcemia resolved with glucocorticoid supplementation and correction of the dehydration. The diabetes mellitus and adrenal insufficiency both resolved within 9 weeks.
authors.affiliation: Department of Clinical Sciences College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Smith
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Freeman
authors.forename: Mary
authors.initials: M
authors.lastname: Bagladi-Swanson
mesh_terms: D000309:Adrenal Insufficiency / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D002415:Cats; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*; D005260:Female; D005440:Fluid Therapy / Q000662:veterinary; D006934:Hypercalcemia / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*; D007049:Iatrogenic Disease / Q000662:veterinary*; D007273:Injections, Intramuscular; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D000077555:Methylprednisolone Acetate
chemical_list: D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone