[The regulation of apoptosis by Bcl-2, bcl-X(L), Bcl-2alpha and Bax in chronic liver disease].
OBJECTIVE
To analyse the expression of Fas and Fas ligand (FasL) in patients of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma and to study the regulation of apotosis by Bax and Bcl-2 subfamilies.


METHODS
The subfamily of Bcl-2 in the liver tissue was studied by immunohistochemistry.


RESULTS
In 156 cases of chronic liver disease the expression levels of Fas and FasL in the chronic hepatitis group were significantly higher than that in hepatocellular carcinoma group(P < 0.01). The expression level of Bax subfamily in the chronic hepatitis group was significantly higher than that of Bcl-2 subfamily.


CONCLUSIONS
It is suggested that Bcl-2 family is involved in the regulation of apoptosis in the chronic liver diseases.
Chen
N
N
Institute of Liver Disease, Beijing Military General Hospital, Beijing 100700, China.
Deng
T
T
Chen
P
P
Li
L
L
D017209:Apoptosis; D006521:Hepatitis, Chronic / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein
C494826:BAX protein, human; C494811:BCL2L1 protein, human; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein