Factor V Leiden and prothrombin gene mutation in inflammatory bowel disease in a Mediterranean area.
BACKGROUND
Thromboembolism has been reported to be associated with inflammatory bowel disease.


OBJECTIVE
To evaluate the association of factor V Leiden and prothrombin gene mutation with inflammatory bowel disease in a population of patients with thromboembolic events and inflammatory bowel disease and in a control population of patients with inflammatory bowel disease without thromboembolic events.


METHODS
A series of 18 patients with inflammatory bowel disease and a history of arterial or venous thrombosis and 45 patients with inflammatory bowel disease without thromboembolic events were evaluated for the presence of factor V Leiden and prothrombin gene mutation. Frequency of gene mutation was compared with its occurrence in 100 healthy controls.


RESULTS
One patient with inflammatory bowel disease without thromboembolic events was heterozygous for factor V Leiden mutation. whereas no patient with a thromboembolic event had factor V Leiden mutation. No patients (either cases or controls) had prothrombin gene mutation. In the healthy population the frequency of factor V Leiden and prothrombin mutation was 5% and 2%, respectively.


CONCLUSIONS
Data emerging from the present study do not support any role of factor V Leiden and prothrombin gene mutation as the cause of thromboembolism in inflammatory bowel disease.
Turri
D
D
University of Palermo, Italy.
Rosselli
M
M
Simioni
P
P
Tormene
D
D
Grimaudo
S
S
Martorana
G
G
Siragusa
S
S
Mariani
G
G
Cottone
M
M
Siracusa
S
S
D003093:Colitis, Ulcerative / Q000097:blood / Q000235:genetics*; D003424:Crohn Disease / Q000097:blood / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D019083:Mediterranean Region; D008875:Middle Aged; D017354:Point Mutation; D015995:Prevalence; D011516:Prothrombin / Q000235:genetics; D013923:Thromboembolism / Q000097:blood / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin