[Polymorphism of glutathione-S transferase M1 gene in patients with generalized forms of surgical infection].
Polymorphism of glutathione S-transferase M1 (GSTM1) locus was analyzed with PCR in patients with generalized forms of surgical infection (n = 47) and in healthy donors (n = 80). Reliable difference was revealed in distribution of zero genotype between patients with sepsis and septic shock (chi 2 = 8.37; p = 0.007) and also between patients with sepsis and organs insufficiency (chi 2 = 5.79; p = 0.02). There were no reliable differences between patients with sepsis and control group (chi 2 = 1.29; p = 0.32). It is concluded that patients--carriers of deletion of GSTM1 gene in homozygote have increased probability of septic shock and polyorganic insufficiency in surgical infection. It can be used as a negative prognostic criterion in clinical practice.
Viktorov
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D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D017353:Gene Deletion; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000235:genetics*; D011110:Polymorphism, Genetic; D011183:Postoperative Complications; D011336:Probability; D011379:Prognosis; D018805:Sepsis / Q000235:genetics*; D012772:Shock, Septic / Q000235:genetics*
D005982:Glutathione Transferase