Cardiotoxicity in imipramine intoxication: report of one case.
Imipramine is the most commonly prescribed tricyclic antidepressant of acute life threatening self-poisoning. We report a 15-month-old boy of accidental poisoning with imipramine, who developed generalized tonic-clonic convulsions and drug-related cardiac conduction abnormalities with PR prolongation, QRS widening, and QTc lengthening. The patient's imipramine level was 1389 ng/ml. The rapid resolution of intraventricular conduction delay and normalization of the QRS-T complexes after gastric lavage, installation of activated charcoal and alkalinization of the blood strongly implicates imipramine intoxication in the etiology of the cardiotoxicity. The patient made a full recovery without neurological sequelae.
Lin
M H
MH
Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan.
Hung
K L
KL
Wang
N K
NK
Shen
C T
CT
D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D004562:Electrocardiography / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D007099:Imipramine / Q000506:poisoning*; D007223:Infant; D008297:Male
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine