Effect of MS-153 on the development of behavioral sensitization to stereotypy-inducing effect of phencyclidine.
The present study examined the effects of a novel compound, MS-153 [(R)-(-)-5-methyl-1-nicotinyl-2-pyrazoline], which has an ability to enhance glutamate uptake and inhibit glutamate release, on the development of behavioral sensitization to phencyclidine (PCP). MS-153 (10 and 100 mg/kg) enhanced stereotypy induced by a single injection of PCP (7.5 mg/kg). Repeated administration of PCP (20 mg/kg, once every day for 5 days) enhanced stereotypy-inducing effects of PCP (7.5 mg/kg) when tested 4 days after the withdrawal from the repeated PCP treatment, indicating the development of behavioral sensitization. MS-153 given 60 and 120 min after the PCP treatments blocked the development of behavioral sensitization to stereotypy-inducing effects of PCP. These results suggest that the attenuation of glutamatergic neural transmission enhances acute effect of PCP, but in contrast, blocks the behavioral sensitization to PCP.
Abekawa
Tomohiro
T
Department of Psychiatry, Hokkaido University, Graduate School of Medicine Kita 15, Nishi 7, Sapporo, Japan.
Honda
Minoru
M
Ito
Kouichi
K
Inoue
Takeshi
T
Koyama
Tsukasa
T
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D018698:Glutamic Acid / Q000502:physiology; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology*; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019956:Stereotypic Movement Disorder / Q000139:chemically induced / Q000188:drug therapy*; D009435:Synaptic Transmission / Q000187:drug effects
C101692:5-methyl-1-nicotinoyl-2-pyrazoline; D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D009539:Nicotinic Acids; D018698:Glutamic Acid; D010622:Phencyclidine