Cytotoxicity of 6,16-disubstituted analogues of (-)-vincadifformine.
Eight analogues of (-)-16-chloro-1-dehydro-6S-bromovincadifformine 1 were synthesized and evaluated for cytotoxicity in L1210 cell culture. None of the new compounds was more active than 1 but the modulation at C6, C16 and on the aromatic ring at C10 informs about structure-activity relationships within this series.
Lewin
Guy
G
Laboratoire de Pharmacognosie (BIOCIS, UPRES-A 8076 CNRS), Faculté de Pharmacie, av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France.guy.lewin@cep.u-psud.fr
Hocquemiller
Reynald
R
Schaeffer
Corinne
C
Lambert
Pierre-Hervé
PH
Léonce
Stéphane
S
Pierré
Alain
A
D000470:Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003432:Cross-Linking Reagents; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; C456406:vincadifformine