title: Detouring destruction: a role for inhibitory neuronal activity in preventing neuronal loss--implications for Alzheimer's disease.
abstract: Recent results from the author's efforts and others have indicated approaches that may eventually lead to new therapeutic strategies for combating neurodegenerative effects associated with dementia and Alzheimer's disease (AD). These strategies include unraveling mechanisms that decrease senile plaque accumulation and delay or slow the neurodegenerative progression associated with AD. Recent work addresses whether normally functioning inhibitory brain circuitry can protect and detour neurodegeneration. The aim of these research efforts is that one or a combination of these approaches will develop into an applied therapy that will enhance brain protection mechanisms and add to quality of life for patients with AD.
authors.affiliation: College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA. rgraf@westernu.edu
authors.forename: R A
authors.initials: RA
authors.lastname: Graf
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000188:drug therapy*; D000818:Animals; D017209:Apoptosis; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000188:drug therapy* / Q000517:prevention & control*; D009474:Neurons / Q000187:drug effects*; D009480:Neuropharmacology