Outbreak of aseptic meningitis and mumps after mass vaccination with MMR vaccine using the Leningrad-Zagreb mumps strain.
Data from routine surveillance during two mass immunisation campaigns (MIC) with Measles-mumps-rubella (MMR)vaccine using Leningrad-Zagreb mumps strain in two states in Brazil were analysed to estimate the risk of vaccine-related meningitis and mumps. Increase in the incidence of the two diseases was observed in both states, 3 weeks after the vaccination campaigns. The estimated number of doses applied per one case of vaccine-related meningitis ranged from 6199 (95% CI: 4854-8058) to 19,247 (95% CI: 12,648-29,513) depending on the diagnostic criteria used and state. It was 300 doses (95% CI: 286-317) for each case of mumps. The implications for vaccination policy are discussed.
da Cunha
Sérgio Souza
SS
Instituto de Saúde Coletiva, Federal University of Bahia, Bahia, Brazil. sergio.cunha@lshtm.ac.uk
Rodrigues
Laura C
LC
Barreto
Maurício L
ML
Dourado
Inês
I
D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D006801:Humans; D007223:Infant; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects*; D008582:Meningitis, Aseptic / Q000453:epidemiology*; D009107:Mumps / Q000453:epidemiology*; D014611:Vaccination / Q000009:adverse effects*
D022542:Measles-Mumps-Rubella Vaccine