[Clinical observation on effect of changmaishu in treating patients of coronary heart disease complicated with hyperviscosity].
OBJECTIVE
To explore the therapeutic effect and mechanism of Changmaishu (CMS) in treating coronary heart disease (CHD).


METHODS
Eighty patients with CHD complicated with hyperviscosity were treated with CMS for a period of 30 days as the CMS group, and the 40 patients treated with Salvia injection and Di'ao Xinxuekang were taken as the control group. The therapeutic efficacy and effect of treatment on plasma lipid peroxide (LPO) content, superoxide dismutase (SOD) activity, blood lipids, hemorrheologic indexes were observed.


RESULTS
The CMS group was better in clinical total effective rate, ECG improvement and concomitant symptoms relieved than those in the control group (P < 0.05 or P < 0.01). Markedly improvement of laboratory findings occurred in both groups (P < 0.05 or P < 0.01), but the changes of some parameters, such as LPO, SOD, total cholesterol, low-shear blood viscosity in the CMS group were more significant than those in the control group (P < 0.05).


CONCLUSIONS
CMS could reduce the blood hyperviscosity, increase antioxidative energy and improve symptoms of CHD effectively.
Liu
T
T
Department of Pathophysiology, Weifang Medical College, Shandong.
Wang
J
J
Song
X
X
D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use; D001809:Blood Viscosity / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D018056:Hemorheology; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; C000607514:di'ao xinxuekang; D002784:Cholesterol; D013482:Superoxide Dismutase