title: Paranasal sinus mucormycosis: a report of two cases.
abstract: Mucormycosis of the nose and paranasal sinuses is a rare invasive fungal infection, which often has a very fulminant course and characteristic clinical findings. The patients are usually immunocompromised, with diabetic ketoacidosis being the commonest underlying disorder. In some immunocompetent patients, the disease is associated with local predisposing factors, such as chronic sinusitis. Although the prognosis has improved in recent decades, the disease can still be fatal. The underlying disease is an important determinant of prognosis and correction of the metabolic disorder, if present, is essential. Herein we report two cases: one of our patients was immunocompetent but had earlier suffered from polypous rhinosinusitis whereas the other had mild adult-type diabetes. Both patients were successfully treated with surgical debridement and amphotericin B.
authors.affiliation: Department of Otorhinolaryngology, Kuopio University Hospital, Finland. pirkko.ruoppi@kuh.fi
authors.forename: P
authors.initials: P
authors.lastname: Ruoppi
authors.forename: A
authors.initials: A
authors.lastname: Dietz
authors.forename: E
authors.initials: E
authors.lastname: Nikanne
authors.forename: J
authors.initials: J
authors.lastname: Seppa
authors.forename: H
authors.initials: H
authors.lastname: Markkanen
authors.forename: J
authors.initials: J
authors.lastname: Nuutinen
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000134:cerebrospinal fluid; D002939:Ciprofloxacin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D015523:Maxillary Sinusitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D009915:Orbit / Q000000981:diagnostic imaging / Q000382:microbiology / Q000601:surgery; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D019651:Plastic Surgery Procedures / Q000379:methods; D014025:Titanium / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D002939:Ciprofloxacin; D000666:Amphotericin B; D002097:C-Reactive Protein; D014025:Titanium