title: [The influence of the hemoglobin concentration on the hematogenous tumor cell dissemination at the time of the initial diagnosis of breast cancer].
abstract: OBJECTIVE
  In the last few years special attention has been paid to the serum concentration of haemoglobin in patients with cancer. It was the aim of this study to ascertain whether at the time of the initial diagnosis low haemoglobin levels in patients with breast cancer denote a higher risk of primary haematogenous dissemination of tumour cells in bone marrow than that in those with higher levels.
  
  
  METHODS
  Between March 1994 and March 2000 bone marrow aspirates were performed and serum haemoglobin concentrations (g/dl) measured before primary surgical treatment in 360 consecutive patients (mean age 57.5 years) with primary breast cancer. Evidence of isolated tumour cells in bone marrow was obtained with the pancytokeratin antibody A45-B/B3. The cohort was divided into two groups on the basis of mean haemoglobin values, and the patients underwent follow-up examination a mean of 30.7 months after the initial diagnosis. Patients with metastases at first diagnosis or those who had received nonsurgical treatment at that time were excluded.
  
  
  RESULTS
  The mean pre-treatment haemoglobin concentration of the cohort was 13.8 g/dl (median 13.9 g/dl, S.D.1.2). There was no statistically significant difference in the frequency of cytokeratin-positive bone marrow findings between the two groups. While disseminated tumour cells were demonstrated in the bone marrow of 48 (28%) patients with a pre-treatment haemoglobin of </= 13.9 g/dl (p = 0.50), this was so in 58 patients (31%) with a pre-treatment haemoglobin of > 13.9 g/dl. There was also no difference between the two groups regarding median survival time (67.9 vs. 65.8 months; p = 0.46). However, there was a significant difference in probability of survival between patients with or without isolated tumour cells in the bone-marrow (59.7 vs. 69.2 months; p < 0.0001).
  
  
  CONCLUSIONS
  There is no evidence at present that the preoperative haemoglobin concentration is of prognostic value regarding the haematogenous dissemination of tumour cells and the survival time of patients with primary breast cancer.
authors.affiliation: I. Frauenklinik, Klinikum der Ludwig-Maximilians-Universtität München, Germany. janni@fk-i.med.uni-muenchen.de
authors.forename: W
authors.initials: W
authors.lastname: Janni
authors.forename: B
authors.initials: B
authors.lastname: Strobl
authors.forename: B
authors.initials: B
authors.lastname: Rack
authors.forename: D
authors.initials: D
authors.lastname: Rjosk
authors.forename: C
authors.initials: C
authors.lastname: Schindlbeck
authors.forename: P
authors.initials: P
authors.lastname: Hantschmann
authors.forename: C
authors.initials: C
authors.lastname: Kentenich
authors.forename: W
authors.initials: W
authors.lastname: Sigg
authors.forename: M
authors.initials: M
authors.lastname: Zerzer
authors.forename: H
authors.initials: H
authors.lastname: Sommer
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000097:blood / Q000556:secondary*; D001943:Breast Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D006454:Hemoglobins