title: Eremophilanolides and other constituents from the Argentine liverwort Frullania brasiliensis.
abstract: Two eremophilanolides, 5-epidilatanolides A and B, as well as a new natural bibenzyl were isolated from an Argentine collection of the liverwort Frullania brasiliensis, along with the known eudesmane-type sesquiterpene lactones nepalensolide A, nepalensolide B, (+)-frullanolide, and (+)-dihydrofrullanolide, the hopanoid zeorin, the four sterols stigmasta-4,22-dien-3,6-dione, stigmasta-4,22-dien-3-one, stigmasterol, and sitosterol, and a trace amount of atraric acid. The structure and stereochemistry of the eremophilanolides and the bibenzyl were established by a combination of extensive NMR spectroscopy experiments and X-ray crystallographic analysis. Absolute configurations of the new compounds were derived on the basis of CD spectra.
authors.affiliation: Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho 471, Tucumán 4000, Argentina. alisan@unt.edu.ar
authors.forename: Alicia
authors.initials: A
authors.lastname: Bardón
authors.forename: Graciela Bovi
authors.initials: GB
authors.lastname: Mitre
authors.forename: Norma
authors.initials: N
authors.lastname: Kamiya
authors.forename: Masao
authors.initials: M
authors.lastname: Toyota
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes
chemical_list: C450220:5-epidilatanolide A; C450219:5-epidilatanolide B; D001632:Bibenzyls; D009281:Naphthalenes; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C018286:eremophilane compounds