[The prognostic research of expression and relationship between Helicobacter pylori of c-met oncogene correlation with gastric mucosal proliferation].
OBJECTIVE
To determine whether there is a relationship between Helicobacter pylori (Hp) and expression of c-met oncogene and proliferating cell nuclear antigen (PCNA) in gastric mucosal lesions, and prognostic significance of gastric carcinomas(GC).


METHODS
Expression of c-met and PCNA were investigated in 145 gastric mucosal lesions by using immunohistochemistry. Hp was examined by Warthin-Starry method.


RESULTS
For chronic superficial gastritis (CSG), chronic atrophic gastritis and intestinal metaplasia (CAS + IM), dysplasia(DYS), early GC and advanced GC, the positive rates of c-met and PCNA were higher in IM, DYS and GC than in CSG (P < 0.05). Expressions of c-met and PCNA increased with the increasing proliferation of gastric mucosa, in rank correlation test, they had a close relationship (P < 0.01). Expressions of c-met and PCNA were correlated significantly with histologic type, serosal invasion and lymph node metastasis. In particular, the expression of c-met and PCNA were significantly higher in Borrmann type 4 GC, type 3 GC and type 1, 2 than in early GC(P < 0.05). By rank correlation test, c-met and PCNA have a close relationship (P < 0.001). Expressions of c-met of Hp positive were higher than Hp negative in intestinal GC (P < 0.05). Expressions of c-met were correlated significantly with Hp positive in CAG + IM, DYS and GC. The survival rate of patients with Hp infection was significantly poorer than that of patients with Hp non-infection.


CONCLUSIONS
The expression of c-met may be is associated with proliferation and malignant transformation of gastric mucosa. These results suggest that expression of c-met may be a new prognostic factor in gastric carcinoma. Hp infection and expression of c-met may be associated with in proliferation and malignant transformation of gastric mucosa. Hp infection is associated with prognosis of gastric carcinoma.
Zhuang
X
X
Department of Gastroenterology, Guangzhou Military General Hospital, Guangzhou 510010, China.
Lin
S
S
Zheng
J
J
Wang
L
L
Sun
G
G
Li
Y
Y
D049109:Cell Proliferation; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology
D018809:Proliferating Cell Nuclear Antigen; D019859:Proto-Oncogene Proteins c-met