Chemical genomics in the global study of protein functions.
Small, cell-permeable and target-specific chemical ligands offer great therapeutic value. They can also be used to dissect diverse biological processes, such as cellular metabolism, signal transduction and intracellular protein trafficking. With cutting-edge technologies in synthetic chemistry and ligand screening and identification, chemical ligands have become more readily available for research. Chemical ligands are used increasingly in genomics approaches to understand the global functions of proteins, an emerging frontier called 'chemical genomics'. Chemical genomics should greatly accelerate discovery in biology and medicine in the near future.
Zheng
X F Steven
XF
Department of Pathology, and Immunology, Campus Box 8069, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. zheng@pathbox.wustl.edu
Chan
Ting-Fung
TF
D002621:Chemistry / Q000639:trends*; D002874:Chromosome Mapping; D005786:Gene Expression Regulation; D023281:Genomics / Q000639:trends*; D006801:Humans; D008024:Ligands; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry* / Q000502:physiology*
D008024:Ligands; D011506:Proteins