title: Conditioned taste aversion to saccharin induced by 2, 4, 5-trichlorophenoxyacetic acid in albino rats.
abstract: Four groups of Wistar rats were exposed either to saccharin + 2,4,5-T (taste-aversion group, T-A), saccharin + oil vehicle (taste-aversion control, T-A C), water + 2,4,5-T (enhanced neophobia, E-N), or water + oil (neophobia, N). Rats in the T-A group evidenced a marked aversion to saccharin in 3 consecutive preference tests, performed every third day, starting 3 days after exposure. The aversion was less pronounced, although statistically significant in 2 additional preference tests, performed respectively after a 9-day rest period of ad lib water drinking, and a 24 hr period of forced exposure to saccharin. An enhanced neophobia effect was found in the E-N group in the first preference test. Suggestions are made concerning the possible long-term effects on food preferences among wild-living animals as a result of large-scale application of 2,4,5-T-containing herbicides.
authors.affiliation: Neurophysiological Laboratory, Ulleråker Hospital, Uppsala University, S-75017 Uppsala, Sweden.
authors.forename: P O
authors.initials: PO
authors.lastname: Sjödén
authors.forename: T
authors.initials: T
authors.lastname: Archer
mesh_terms: D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D005518:Food Preferences / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012153:Retention, Psychology / Q000187:drug effects; D012439:Saccharin; D013649:Taste / Q000187:drug effects*
chemical_list: D015085:2,4,5-Trichlorophenoxyacetic Acid; D012439:Saccharin