Cyclophosphamide therapy in a serious case of lupus nephritis during pregnancy.
Systemic lupus erythematosus (SLE) flare is common, and renal involvement is one of the most serious problems during pregnancy. Aggressive immunosuppressive therapy should be considered for patients with diffuse proliferative lupus nephritis. These individuals are at high risk for progression to end-stage renal disease. Immunosuppressive drugs can cause significant toxic and teratogenetic effects. In this report, we describe the case of a pregnant patient with lupus nephritis who was treated with cyclophosphamide. The patient was in the second trimester of her first pregnancy and did not respond to corticosteroid therapy. She underwent intensive in-hospital care while she was on cyclophosphamide therapy. Both mother and baby were well at delivery.
Kart Köseoglu
H
H
Division of Rheumatology, Baskent University, Faculty of Medicine, Ankara, Turkey.
Yücel
A E
AE
Künefeci
G
G
Ozdemir
F N
FN
Duran
H
H
D000293:Adolescent; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008181:Lupus Nephritis / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide