The past, present and future of HIV-vaccine development: a critical view.
Despite the extensive efforts that have been made to combat AIDS, the global number of HIV-1 infections is still increasing. There is major consent among scientists worldwide, that the development of successful HIV vaccine strategies requires a profound understanding of the epidemiological principles of a viral pandemic, as well as deep insights into the molecular and immunological mechanisms of HIV pathogenesis. This review provides an overview of past and present developments, as well as future aspects of HIV vaccines, and also provides a summary of current clinical trials in man.
Bojak
Alexandra
A
Institute of Medical Microbiology and Hygiene, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany.
Deml
Ludwig
L
Wagner
Ralf
R
D016915:AIDS Vaccines / Q000737:chemistry / Q000266:history / Q000276:immunology; D002986:Clinical Trials as Topic; D005060:Europe; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans
D016915:AIDS Vaccines