title: Mycobacterium-specific human CD8 T cell responses.
abstract: Tuberculosis (TB) remains a global health problem. There is an intense effort to identify correlates of protective immunity and to design new TB vaccines. CD8 T cells are thought to play a significant role in controlling Mycobacterium tuberculosis infection. Relatively little has been published about the antigens and epitopes targeted by mycobacteria-specific CD8 T cells. Here we present an update of our 1999 overview of human CD8 T cell epitopes in mycobacterial antigens and discuss related issues relevant to TB diagnosis and vaccine development.
authors.affiliation: Tuberculosis Research Programme, Medical Research Council (MRC) Laboratories, Banjul, The Gambia, West Africa. mklein@mrc.gm
authors.forename: M R
authors.initials: MR
authors.lastname: Klein
authors.forename: A
authors.initials: A
authors.lastname: Fox
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D001500:BCG Vaccine / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D000939:Epitopes / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D007159:Immunologic Tests; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D011379:Prognosis; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control; D022223:Vaccines, Subunit / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D001500:BCG Vaccine; D000939:Epitopes; D022223:Vaccines, Subunit