Poly(glutamic acid) for biomedical applications.
Paclitaxel is a widely used anti-cancer agent. Conjugates of paclitaxel with poly(glutamic acid) have shown great promise in preclinical trials, and clinical trials are now underway. Preclinical data suggest that more paclitaxel is preferentially delivered to tumor sites vs. nonconjugated paclitaxel. When poly(glutamic acid) is conjugated to other families of cancer drugs, similar improvements in effectiveness and reduced toxicity are observed. Optimization of poly(glutamic acid) for use in drug delivery applications is a key step in making this technology viable.
Richard
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Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Canada.
Margaritis
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D016503:Drug Delivery Systems; D010447:Peptide Hydrolases / Q000378:metabolism; D011099:Polyglutamic Acid / Q000008:administration & dosage* / Q000096:biosynthesis / Q000378:metabolism
D011099:Polyglutamic Acid; D010447:Peptide Hydrolases; C443639:polyglutamyl gamma-hydrolase