title: Intrathecal gadolinium-enhanced MR cisternography in the evaluation of clinically suspected cerebrospinal fluid rhinorrhea in humans: early experience.
abstract: In this prospective multicenter study, the authors evaluated the utility of magnetic resonance (MR) cisternography after intrathecal administration of gadopentetate dimeglumine in 15 patients clinically suspected of having cerebrospinal fluid (CSF) rhinorrhea. By means of lumbar puncture, a single dose of 0.5 mL of gadopentetate dimeglumine was injected into the lumbar subarachnoid space. Thirteen patients showed leakage of contrast material through the cribriform plate into the ethmoid or sphenoid air cells. No leakage was observed in two patients. The study results show the relative safety and feasibility of low-dose gadolinium-enhanced MR cisternography in confirming the presence and determining the focus of active CSF leaks.
authors.affiliation: Department of Radiological Sciences, Medical College of Pennsylvania-Hahnemann University, 245 N 15th St, Mailstop 206, Philadelphia, PA 19102-1192, USA. jrjinkins@aol.com
authors.forename: J Randy
authors.initials: JR
authors.lastname: Jinkins
authors.forename: Mohamed
authors.initials: M
authors.lastname: Rudwan
authors.forename: Gaida
authors.initials: G
authors.lastname: Krumina
authors.forename: E Turgut
authors.initials: ET
authors.lastname: Tali
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002559:Cerebrospinal Fluid Rhinorrhea / Q000175:diagnosis*; D002648:Child; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009485:Neuroradiography / Q000379:methods; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA