Intrahepatic distribution of human glutathione-dependent formaldehyde dehydrogenase.
By means of a microelectrophoretic separation technique the different forms of alcohol dehydrogenase can be detected in microdissected liver tissue samples of the nanogram range. Alcohol dehydrogenase 3 (the glutathione-dependent formaldehyde dehydrogenase) was demonstrated to be zonally distributed in the human liver parenchyma. A periportal/perivenous gradient is evident in both sexes, however, the periportal/perivenous ratio is higher in males. The biological functions of this enzymatic form and the possible role of the periportal maximum are discussed.
Maly
P I
PI
Institute of Anatomy, University of Basel, Pestalozzistrasse 20, 4056 Basel, Switzerland.
Crotet
V
V
Toranelli
M
M
Sasse
D
D
D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D008099:Liver / Q000201:enzymology*; D008297:Male; D036103:Nanotechnology; D009929:Organ Size; D012727:Sex Characteristics
C020145:formaldehyde dehydrogenase (glutathione); D000445:Aldehyde Oxidoreductases