title: Successful treatment of vancomycin-resistant enterococcus meningitis with linezolid: case report and review of the literature.
abstract: OBJECTIVE
  To describe the successful treatment of a case of vancomycin-resistant enterococcus meningitis with linezolid.
  
  
  METHODS
  Case report and review of the literature.
  
  
  METHODS
  The patient is a 35-yr-old man who suffered a cerebellar hemorrhage after embolization of a cerebellar arteriovenous malformation. The patient underwent ventriculostomy drainage and craniectomy. The patient was on broad-spectrum antibiotics for pneumonia including vancomycin. The patient remained febrile and grew vancomycin-resistant Enterococcus faecium from the cerebrospinal fluid.
  
  
  METHODS
  The patient was treated with intravenous chloramphenicol without success. On postoperative day 16, the patient was begun on intravenous linezolid.
  
  
  RESULTS
  The patient received 4 wks of intravenous linezolid with complete eradication of the meningitis.
  
  
  CONCLUSIONS
  Intravenous linezolid appears to be a safe and effective therapy for vancomycin-resistant enterococcus meningitis.
authors.affiliation: Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: M P
authors.initials: MP
authors.lastname: Steinmetz
authors.forename: M A
authors.initials: MA
authors.lastname: Vogelbaum
authors.forename: M A
authors.initials: MA
authors.lastname: De Georgia
authors.forename: J C
authors.initials: JC
authors.lastname: Andrefsky
authors.forename: C
authors.initials: C
authors.lastname: Isada
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016984:Enterococcus faecium / Q000187:drug effects; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D000069349:Linezolid; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use*; D020713:Vancomycin Resistance; D014696:Ventriculostomy / Q000009:adverse effects
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid