title: Respiratory chain supercomplexes.
abstract: Respiratory chain supercomplexes have been isolated from mammalian and yeast mitochondria, and bacterial membranes. Functional roles of respiratory chain supercomplexes are catalytic enhancement, substrate channelling, and stabilization of complex I by complex III in mammalian cells. Bacterial supercomplexes are characterized by their relatively high detergent-stability compared to yeast or mammalian supercomplexes that are stable to sonication. The mobility of substrate cytochrome c increases in the order bacterial, yeast, and mammalian respiratory chain. In bacterial supercomplexes, the electron transfer between complexes III and IV involves movement of the mobile head of a tightly bound cytochrome c, whereas the yeast S. cerevisiae seems to use substrate channelling of a mobile cytochrome c, and mammalian respiratory chains have been described to use a cytochrome c pool. Dimeric ATP synthase seems to be specific for mitochondrial OXPHOS systems. Monomeric complex V was found in Acetobacterium woodii and Paracoccus denitrificans.
authors.affiliation: Zentrum der Biologischen Chemie, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany. schagger@zbc.klinik.uni-frankfurt.de
authors.forename: H
authors.initials: H
authors.lastname: Schägger
mesh_terms: D000818:Animals; D019069:Cell Respiration; D004579:Electron Transport; D046911:Macromolecular Substances; D025261:Mitochondrial Proton-Translocating ATPases / Q000737:chemistry / Q000378:metabolism; D010085:Oxidative Phosphorylation; D015003:Yeasts
chemical_list: D046911:Macromolecular Substances; D025261:Mitochondrial Proton-Translocating ATPases