title: [Diffusion weighted MRI: ischemic and traumatic injuries of the central nervous system].
abstract: Diffusion weighted magnetic resonance imaging (DWI) represents a recent development that extends imaging from the depiction of the neuroanatomy into the field of functional and physiologic processes. DWI measures a fundamentally different physiologic parameter than conventional MRI. Image contrast is related to differences in the microscopic motion (diffusion) of water molecules within brain tissue rather than a change in total tissue water. Consequently, DWI can reveal pathology where conventional T1- and T2-weighted MR images are negative. DWI has clinically proven its value in the assessment of acute cerebral stroke and trauma by showing cerebral injury early due to ist ability to discriminate between lesions with cytotoxic edema (decreased diffusion) from lesions with vasogenic edema (increased diffusion). Full tensor DWI allows to calculate a variety of functional maps, the most widely used maps include maps of apparent diffusion coefficients and isotropic diffusion. In addition maps of anisotropic diffusion can be calculated which are believed to give information about the integrity and location of fiber tracts. This functional-anatomical information will most probably play an increasingly important role in the early detection of primary and secondary tissue injury from various reasons and could guide and validate current and future neuroprotective treatments.
authors.affiliation: MGH-NMR Center, Massachusetts General Hospital and Harvard Medical School, Mailingcode 149 (2301), Charlestown-Boston, MA 02119, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Huisman
authors.forename: H
authors.initials: H
authors.lastname: Hawighorst
authors.forename: C H
authors.initials: CH
authors.lastname: Benoit
authors.forename: A G
authors.initials: AG
authors.lastname: Sorensen
mesh_terms: D000818:Animals; D016477:Artifacts; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000175:diagnosis; D001930:Brain Injuries / Q000175:diagnosis*; D002545:Brain Ischemia / Q000175:diagnosis*; D002544:Cerebral Infarction / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004058:Diffusion; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D012680:Sensitivity and Specificity; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000175:diagnosis*; D020760:Spinal Cord Ischemia / Q000175:diagnosis*