title: [Pharmacotherapy for the treatment of Alzheimer's disease--the present state and the development in the future].
abstract: We can observe progressions through stages of symptoms, which are memory and cognitive loss, functional impairment and behavioral disinhibition or apathy, in patients with Alzheimer's disease (AD). Medications of acethylcholine esterase inhibitors such as donepezil offer hope for improving or stabilizing the symptoms of AD temporarily. We desire that new pharmacological interventions up the stream of amyloid cascade theory of AD will be established. Many medical challenges and researches will be tried to find the cause of AD and eternal disease stabilization, or even prevention, may be possible in the future.
authors.affiliation: Department of Neuropsychiatry, St. Marianna University School of Medicine.
authors.forename: Noboru
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: Nagako
authors.initials: N
authors.lastname: Okada
authors.forename: Tsuneyuki
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000209:etiology; D000682:Amyloid / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D002800:Cholinesterase Inhibitors; D015195:Drug Design; D006801:Humans; D009154:Mutation
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D002800:Cholinesterase Inhibitors