title: Metachronous multifocal osteosarcoma: a case report and literature review.
abstract: Metachronous multifocal osteosarcoma (MFOS) is a rare form of osteosarcoma manifested by one or more new tumors developing after the initial treatment of primary osteosarcoma. The pathogenesis of metachronous MFOS is still obscure whether it represents multiple true primaries or metastatic disease. However, there is a clinical significance that metachronous MFOS is a potentially curable disease [Resnick D, Kyriacos M, Greenway GD. Tumors and tumor-like lesions of bone: imaging and pathology of specific lesions. In: Resnick D, editor. Diagnosis of bone and joint disorders. Philadelphia: Saunders, 1995: p. 3697-9.]. To our knowledge, there have been only a few reports about metachronous MFOS. We report a case of MFOS in a 14-year-old boy with review of the literature.
authors.affiliation: Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea.
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Lee
authors.forename: In One
authors.initials: IO
authors.lastname: Kim
authors.forename: Woo Sun
authors.initials: WS
authors.lastname: Kim
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Cheon
authors.forename: Kyoung Won
authors.initials: KW
authors.lastname: Kim
authors.forename: Kyung Mo
authors.initials: KM
authors.lastname: Yeon
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary; D003937:Diagnosis, Differential; D005269:Femur / Q000473:pathology*; D005360:Fibula / Q000473:pathology*; D006801:Humans; D006811:Humerus / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D012516:Osteosarcoma / Q000175:diagnosis* / Q000556:secondary