title: Change in full-field ERGs after macular translocation surgery with 360 degrees retinotomy.
abstract: OBJECTIVE
  One of the methods used in macular translocation (MT) surgery for subfoveal neovascularization is to create a temporary total retinal detachment followed by a 360 degrees retinotomy. The whole retina is then shifted from the original surface of the retinal pigment epithelium (RPE), resulting in an unusual retina and RPE complex. The purpose of this study was to assess retinal function after MT surgery.
  
  
  METHODS
  Full-field electroretinograms (ERGs) were recorded before and 4 to 8 months (mean, 5.4 months) after MT surgery with a 360 degrees retinotomy in 15 consecutive patients with age-related macular degeneration (10 eyes), high myopia (4 eyes), and polypoidal choroidal vasculopathy (1 eye). Their ages ranged from 57 to 74 years. The angle of rotation of the retina ranged from 18 degrees to 45 degrees (mean +/- SE, 30 +/- 2 degrees). In addition to the recording of the standard rod and mixed rod-cone ERGs after 30 minutes of dark adaptation, the cone single flash and 30-Hz flicker ERGs were recorded immediately after a light-adapting background was turned on (LA(0)) and also after 10 minutes of light adaptation (LA(10)).
  
  
  RESULTS
  The mean amplitude of the full-field ERGs was reduced after surgery by 44% for the rod response, by 24% for the mixed rod-cone b-wave, by 12% and 35% for the cone single-flash b-wave at LA(0) and 30-Hz flicker ERGs at LA(0), respectively. The mean implicit times were delayed by 8 msec for the rod response, by 2 msec for the mixed rod-cone oscillatory potential (OP1), by 4 msec for the cone single-flash b-wave at LA(0), and by 6 msec for the 30-Hz flicker at LA(0).
  
  
  CONCLUSIONS
  These results demonstrated a functional alteration in both the rod and cone components of the ERGs for the entire retina after MT surgery.
authors.affiliation: Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan. terasaki@med.nagoya-u.ac.jp
authors.forename: Hiroko
authors.initials: H
authors.lastname: Terasaki
authors.forename: Yozo
authors.initials: Y
authors.lastname: Miyake
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Niwa
authors.forename: Chang-Hua
authors.initials: CH
authors.lastname: Piao
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
authors.forename: Mineo
authors.initials: M
authors.lastname: Kondo
mesh_terms: D000368:Aged; D020256:Choroidal Neovascularization / Q000209:etiology / Q000601:surgery; D003623:Dark Adaptation; D004596:Electroretinography; D006801:Humans; D008266:Macula Lutea / Q000637:transplantation*; D008268:Macular Degeneration / Q000150:complications / Q000601:surgery; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D010775:Photic Stimulation; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology*; D014792:Visual Acuity