title: Advances in Rho-dependent actin regulation and oncogenic transformation.
abstract: Cellular movement is central to invasion. The Rho family of small GTPases co-ordinate the cytoskeletal and adhesion modelling within cells that is crucial for normal migratory responses. Consequently, Rho proteins, and their regulators and effectors, are targets for subversion during oncogenic transformation and tumour development. Recent findings have thrown light on how actin regulators may be linked to oncogenesis and the development of cancer.
authors.affiliation: The Beatson Institute for Cancer Research and Institute of Biomedical and Life Sciences, Cancer Research Campaign Beatson Laboratories, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
authors.forename: Margaret C
authors.initials: MC
authors.lastname: Frame
authors.forename: Valerie G
authors.initials: VG
authors.lastname: Brunton
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology; D000199:Actins / Q000378:metabolism*; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement; D048429:Cell Size; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D006801:Humans; D016023:Integrins / Q000502:physiology; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*
chemical_list: D000199:Actins; D016023:Integrins; D020741:rho GTP-Binding Proteins