[Clinical efficacy of alprostan in combination with "Bioptron-II" rays and iruxol-miramistin in the treatment of the diabetic foot complicated by atherosclerosis].
Experience of clinical treatment of 9 patients with diabetes mellitus and diabetic angiopathy using alprostan in combination with rays "Bioptron-II" and iruxol-miramistinum in conditions of polyclinic was summarized. Antidiabetic preparations, mainly insulin, were administered to all patients together with abovementioned treatment. Optimal scheme of treatment constitutes daily slow (no less than 6 h) dropper intravenous infusion of alprostan in 0.1 mg dosage in 150-200 ml isotonic solution of sodium chloride during 15 days. Before and after infusion of alprostan ulcer was locally irradiated using "Bioptron-II" lamp from 5 cm distance during 6 min, bandage with iruxol-miramistinum ointment was applied in ratio 1:1. In 6 patients pain in lower extremities disappeared, ulcers epithelized, in 3--ulcers reduced by 50%.
Tomashuk
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Tomashuk
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D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000150:complications*; D001548:Benzalkonium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D002701:Chloramphenicol / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D017719:Diabetic Foot / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000627:therapeutic use*; D014466:Ultraviolet Rays; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D001548:Benzalkonium Compounds; D004338:Drug Combinations; D007641:Keratolytic Agents; D014665:Vasodilator Agents; D002701:Chloramphenicol; C005519:iruxol; D003012:Microbial Collagenase; D000527:Alprostadil; C058048:miramistin