Metachronous multifocal osteosarcoma: a case report and literature review.
Metachronous multifocal osteosarcoma (MFOS) is a rare form of osteosarcoma manifested by one or more new tumors developing after the initial treatment of primary osteosarcoma. The pathogenesis of metachronous MFOS is still obscure whether it represents multiple true primaries or metastatic disease. However, there is a clinical significance that metachronous MFOS is a potentially curable disease [Resnick D, Kyriacos M, Greenway GD. Tumors and tumor-like lesions of bone: imaging and pathology of specific lesions. In: Resnick D, editor. Diagnosis of bone and joint disorders. Philadelphia: Saunders, 1995: p. 3697-9.]. To our knowledge, there have been only a few reports about metachronous MFOS. We report a case of MFOS in a 14-year-old boy with review of the literature.
Lee
Hyun Ju
HJ
Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea.
Kim
In One
IO
Kim
Woo Sun
WS
Cheon
Jung Eun
JE
Kim
Kyoung Won
KW
Yeon
Kyung Mo
KM
D000293:Adolescent; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary; D003937:Diagnosis, Differential; D005269:Femur / Q000473:pathology*; D005360:Fibula / Q000473:pathology*; D006801:Humans; D006811:Humerus / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D012516:Osteosarcoma / Q000175:diagnosis* / Q000556:secondary