The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat.
Osmolality changes evoked with intragastric administration of natural honey or mannitol, significantly decreased the gastric ulceration of rats induced by indomethacin. Together with this effect, a parallel increase was detectable in the mucosal level of endogenous prostacyclin. Although many processes may be involved in this phenomenon, the authors explain their data with a stimulating effect on gastric mucosal microcirculation due to osmolality changes.
Gharzouli
K
K
Department of Biologie, Faculte des Sciences, Universite Ferhat Abbas, Setif, Algerie.
Balint
G A
GA
Galfi
M
M
Rimanoczy
A
A
Juhasz
A
A
D000818:Animals; D011464:Epoprostenol / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006722:Honey; D007213:Indomethacin / Q000633:toxicity; D008353:Mannitol / Q000494:pharmacology; D009994:Osmolar Concentration; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism* / Q000628:therapy
D008353:Mannitol; D011464:Epoprostenol; D007213:Indomethacin