title: Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract.
abstract: BACKGROUND
  Dandelion water extract (DWE), an herbal medication, may have an effect on the activity and mRNA expression of hepatic antioxidant enzymes and lipid profile in streptozotocin (STZ)-induced diabetic rats.
  
  
  METHODS
  Male Sprague-Dawley rats were divided into nondiabetic (control), diabetic, and diabetic-DWE-supplemented groups. Diabetes was induced by injecting streptozotocin (55 mg/kg BW, i.p.) in a citrate buffer. The extract was supplemented in 2.4 g of a DWE/kg diet.
  
  
  RESULTS
  The DWE supplement significantly decreased the serum glucose concentration in the diabetic rats. The hepatic superoxide dismutase and catalase activities significantly increased and the GSH-Px activity decreased in the diabetic rats, compared with the control group. When the DWE supplement was given to the diabetic rats, the antioxidant enzyme activity reverted to near-control values. However, there was no difference in the mRNA expression concentrations of these enzymes between the groups. With regard to the hepatic lipid peroxidation product, the malondialdehyde (MDA) content was significantly higher in the diabetic group than in the nondiabetic group. However, the DWE supplement lowered the hepatic MDA concentration in the diabetic-induced rats. The DWE supplement also lowered the total cholesterol and triglyceride concentrations in the serum and hepatic tissue, while increasing the serum HDL-cholesterol in the diabetic rats.
  
  
  CONCLUSIONS
  A DWE supplement can improve the lipid metabolism and is beneficial in preventing diabetic complications from lipid peroxidation and free radicals in diabetic rats.
authors.affiliation: Department of Food and Nutrition, Yeungnam University, Kyongsan 712-749, South Korea.
authors.forename: Soo Yeul
authors.initials: SY
authors.lastname: Cho
authors.forename: Ji Yeun
authors.initials: JY
authors.lastname: Park
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Park
authors.forename: Myung Sook
authors.initials: MS
authors.lastname: Choi
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Seon Min
authors.initials: SM
authors.lastname: Jeon
authors.forename: Moon Kyoo
authors.initials: MK
authors.lastname: Jang
authors.forename: Myung Joo
authors.initials: MJ
authors.lastname: Kim
authors.forename: Yong Bok
authors.initials: YB
authors.lastname: Park
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002374:Catalase / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008055:Lipids; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D013311:Streptozocin; D002784:Cholesterol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase