Ber-EP4 and MNF-116 in a previously undescribed morphologic pattern of granular basal cell carcinoma.
Granular basal cell carcinoma (GBCC) is a rare subtype of basal cell carcinoma (BCC) with only seven previously described cases in the literature. A 65-year-old man presented with a papule on his cheek that was subsequently removed. Histopathologic examination revealed that the neoplasm had no connection to the overlying epidermis and that the neoplasm had two different morphologies; nodules composed solely of granular cells and other nodules with a rim of basaloid cells and central granular cells. The neoplasm stained for both Ber-EPF4 and MNF-116 thus confirming it as a subtype of BCC. GBCC should be considered in the differential diagnosis of nodular neoplasms containing granular cells.
Hayden
A A
AA
Division of Dermatology, Wright State University School of Medicine, Dayton, Ohio, USA.
Shamma
H N
HN
D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology*; D016586:Granular Cell Tumor / Q000473:pathology; D006801:Humans; D015603:Keratinocytes / Q000737:chemistry; D008297:Male; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D000951:Antigens, Neoplasm
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D014408:Biomarkers, Tumor; C115012:human epithelial antigen-125; D000951:Antigens, Neoplasm