Juvenile temporal arteritis is a manifestation of Kimura disease.
An asymptomatic nodule appeared in the right temporal region of an 81-year-old woman. Histopathologic examination confirmed significant thickening of the vascular wall, constriction of the vessel lumen, and infiltration of numerous eosinophils and lymphocytes. Giant cells were not seen. Lymphoid follicles and capillaries surrounded the large vessel. Elastica van Gieson staining revealed a laceration of the internal elastic lamina. Based on these clinical and histologic findings, the patient was diagnosed as having juvenile temporal arteritis (JTA), a disease first proposed by Lie and his colleagues in 1975. Three years later, a new eruption, again asymptomatic, appeared in the posterior region of the patient's right ear. Subsequently, she was referred to our department. Histologic examination of the new lesion confirmed the infiltration of lymphocytes and eosinophils, which was accompanied by numerous lymphoid follicles, and the proliferation of endothelial cells and capillaries from the deep dermis to the subcutaneous tissue. The patient was diagnosed as having Kimura disease, which is a persistent and recurrent illness. We hypothesized that JTA was a partial expression of Kimura disease and investigated whether past cases of JTA could be considered Kimura disease. As a result, we found that most cases of JTA could indeed be considered Kimura disease. Furthermore, we examined the vascular changes in the routinely and elastic fiber-stained sections of three cases with Kimura disease and two cases with angiolymphoid hyperplasia with eosinophilia. The results showed occlusive vascular changes in most samples from these cases, supporting the hypothesis that JTA is an accessory lesion of Kimura disease.
Watanabe
Chiharu
C
Department of Dermatology, Tokyo Medical University, Tokyo, Japan. derma@tokyo-med.ac.jp
Koga
Michiyuki
M
Honda
Yoshihide
Y
Oh-I
Tsunao
T
D000368:Aged; D000369:Aged, 80 and over; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000150:complications / Q000473:pathology* / Q000601:surgery; D001772:Blood Cell Count; D005260:Female; D013700:Giant Cell Arteritis / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006801:Humans