[Tailor-made medicine for bronchial asthma].
Asthma is a complex genetic disorder with variable phenotype, largely attributed to the interactions on environment and multiple genes. Numerous asthma and atopy loci have been reported in studies demonstrating associations and/or linkage levels, and bronchial hyperresponsiveness to alleles of microsatellite markers and single nucleotide polymorphisms with in specific genes. Progress in the field of pharmacogenetics has revealed that the phenotypically different responses of patient to drugs are genetically determined by the polymorphisms in the genes encoding the drug target, such as 5-lipoxigenase and beta 2-adrenergic receptor. The information about polymorphisms, is accumulated, tailor-made medicine will be applicable to medical care of individual asthmatics.
Chibana
Kazuyuki
K
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine.
Ishii
Yoshiki
Y
Fukuda
Takeshi
T
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D001094:Arachidonate 5-Lipoxygenase / Q000235:genetics; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D010597:Pharmacogenetics; D010741:Phospholipases A / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D017455:Receptors, IgE / Q000235:genetics; D019948:Receptors, Interleukin-4 / Q000235:genetics
D018793:Interleukin-13; D018343:Receptors, Adrenergic, beta-2; D017455:Receptors, IgE; D019948:Receptors, Interleukin-4; D015847:Interleukin-4; D001094:Arachidonate 5-Lipoxygenase; D010741:Phospholipases A; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase