title: MEN-2A syndrome and pulmonary metastasis.
abstract: A case of multiple endocrine neoplasia syndrome type-2A (MEN-2A) with primary hyperparathyroidism and medullary carcinoma of thyroid initially treated by surgery is reported. The presence of pulmonary nodules six years after the initial treatment was thought to be related to metastasis of medullary carcinoma, and the increase in serum calcium concentrations was assumed to be caused by persistence of parathyroid adenomatous or hyperplastic tissue. The patient underwent surgery again and the pulmonary nodules were confirmed to be metastases of a parathyroid carcinoma, a very rare entity in MEN-2A syndrome.
authors.affiliation: Division of Endocrinology and Nutrition, Clínica Puerta de Hierro, Madrid, Spain. jalfaro@arrakis.es
authors.forename: J J
authors.initials: JJ
authors.lastname: Alfaro
authors.forename: C
authors.initials: C
authors.lastname: Lamas
authors.forename: J
authors.initials: J
authors.lastname: Estrada
authors.forename: T
authors.initials: T
authors.lastname: Lucas
mesh_terms: D000236:Adenoma / Q000473:pathology*; D018276:Carcinoma, Medullary / Q000175:diagnosis; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D018813:Multiple Endocrine Neoplasia Type 2a / Q000175:diagnosis*; D010282:Parathyroid Neoplasms / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis