title: A cytotoxic secocycloartenoid from Abies koreana.
abstract: Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9beta-lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with beta-sitosterol (2), maltol (3), beta-sitosterol-O-beta-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.
authors.affiliation: Colleges of Pharmacy, Chonnam National University, Kwangju, Korea.
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: Q K
authors.initials: QK
authors.lastname: Le
authors.forename: M H
authors.initials: MH
authors.lastname: Lee
authors.forename: T S
authors.initials: TS
authors.lastname: Kim
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Bae
authors.forename: I S
authors.initials: IS
authors.lastname: Lee
mesh_terms: D028202:Abies / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C457235:24-methylene-3,4-secocycloart-4(28)-en-3-oic acid; C457236:3-oxolanosta-7,22,24-trien-26,23-olide; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes