Phosphoserine-dependent regulation of protein-protein interactions in the Smad pathway.
Transforming growth factor beta (TGF-beta) is a secreted growth factor that regulates the transcriptional program of cells via heteromeric complexes of transmembrane type II and type I Ser/Thr kinase receptors and the Smad intracellular signal transduction pathway [1]. The activity of this pathway is tightly controlled by serine phosphorylation, which plays a key role in regulating protein-protein interactions that are critical in the elaboration of transcriptional responses.
Wrana
Jeffrey L
JL
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D010766:Phosphorylation; D010768:Phosphoserine / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D004268:DNA-Binding Proteins; D011956:Receptors, Cell Surface; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D010768:Phosphoserine