Nodes of Ranvier come of age.
Sodium channel subtypes are frequently coexpressed within neurons. Recent studies demonstrate that targeting of specific channel subtypes to distinct membrane domains of axons is regulated by local signals from myelinating glia; they also show that channel subtypes are sequentially expressed at nodes of Ranvier, indicating an unexpected regulation in the composition of these domains.
Salzer
James L
JL
Dept of Cell Biology, Neurology and the Kaplan Cancer Center, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA. jim.salzer@med.nyu.edu
D000818:Animals; D001369:Axons / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D062551:NAV1.2 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009420:Nervous System / Q000378:metabolism*; D009457:Neuroglia / Q000378:metabolism*; D011901:Ranvier's Nodes / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D015222:Sodium Channels / Q000235:genetics / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism
D062551:NAV1.2 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins; C568251:SCN2A protein, human; D015222:Sodium Channels; D029961:Zebrafish Proteins; C430124:scn8ab protein, zebrafish