Se-methylselenocysteine: a new compound for chemoprevention of breast cancer.
Selenium compounds have attracted renewed interest as chemopreventive agents for human cancer on the basis of the pioneering intervention study by Clark and co-workers. The rodent mammary gland has been used extensively as a model for examining the chemopreventive activities of inorganic and organic selenium compounds. This review summarizes the rationale and results for use of a new organic selenium compound, Se-methylselenocysteine, which exhibits greater efficacy as a chemopreventive agent than several previously used selenium compounds in experimental models of breast cancer and has potential for use in human populations.
Medina
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Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. dmedina@bcm.tmc.edu
Thompson
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Ganther
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Ip
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D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000517:prevention & control*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control*; D016566:Organoselenium Compounds / Q000627:therapeutic use*; D017279:Selenocysteine / Q000031:analogs & derivatives; D016896:Treatment Outcome
D016588:Anticarcinogenic Agents; D016566:Organoselenium Compounds; D017279:Selenocysteine; D003545:Cysteine; C002979:selenomethylselenocysteine