Ocular dominance in extrastriate cortex of strabismic amblyopic cats.
Ocular dominance in extrastriate visual cortex of cats with behaviorally defined strabismic amblyopia was studied using extracellular recording techniques. In area 18, the amblyopic eye drove about as many cells as the normal one. In area posteromedial lateral suprasylvian area (PMLS), about 60% of the cells responded exclusively to stimulation of the normal eye and 30% to stimulation of the amblyopic eye. In area 21a more than 75% of the cells were monocularly driven by the non-amblyopic eye while only 5% were monocularly driven by the amblyopic eye. These findings suggest that ventral pathways (area 21a) are more affected in amblyopia than dorsal pathways (area PMLS).
Schröder
Jan-Hinrich
JH
Max Planck Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany. schroeder@mpih-frankfurt.mpg.de
Fries
Pascal
P
Roelfsema
Pieter R
PR
Singer
Wolf
W
Engel
Andreas K
AK
D000550:Amblyopia / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D016010:Binomial Distribution; D002415:Cats; D016001:Confidence Intervals; D004192:Discrimination, Psychological / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology*; D008839:Microelectrodes; D009010:Monte Carlo Method; D011594:Psychometrics; D013285:Strabismus / Q000150:complications / Q000503:physiopathology*; D014793:Visual Cortex / Q000502:physiology*