[Effect of yangxue antai granule in preventing and treating habitual abortion and its effect on short life T-suppressor cell].
OBJECTIVE
To study the influence of T-suppressor cell (Ts cell) on habitual abortion (HA) and to observe the regulatory effect of Yangxue Antai Granule (YXATG) on Ts cell and its effect on fetus preservation.


METHODS
Ts cell activity of 56 pregnant women with HA history was tested with method of shot life Ts cell activity (MTT method) during early pregnancy, and were followed up in middle and late pregnancy in 20 cases of them. All the 56 patients received YXATG treatment. Groups of normal early pregnant, normal non-pregnant and non-pregnant women but with history of habitual abortion were involved in this study as control.


RESULTS
Ts cell activity in early pregnancy was lower than that of middle and late pregnancy (P < 0.01, P < 0.001), and also lower than that of the control groups (P < 0.01, P < 0.001). The successful rate of fetus preservation of YXATG was 98.2%, and 98.0% of the cases got a normal delivery.


CONCLUSIONS
Low Ts cell activity might be the immunologic etiology of HA. The fetus preservative effect of YXATG might be due to its regulatory effect on Ts cell.
Li
E
E
Beijing Hospital of Gynaecology and Obstetrics, Beijing (100006).
Li
M
M
Gao
A
A
D000026:Abortion, Habitual / Q000276:immunology / Q000517:prevention & control*; D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011247:Pregnancy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D004365:Drugs, Chinese Herbal