title: Characteristics of bone morphogenetic protein-induced chondroid bone: histochemical, immunohistochemical and in situ hybridization examinations.
abstract: The third ossification mode, known as transchondroid bone formation, is displayed chiefly in the bone morphogenetic protein (BMP)-induced heterotopic bone formation model. This paper describes the results of histopathological, histochemical, immunohistochemical, and in situ hybridization examinations of BMP-induced heterotopic bone in mice. The research focuses on the localization of typical matrix proteins (peptide and its mRNA) of cartilage and bone--type-I and type-II collagen, osteocalcin and osteopontin--in the chondroid bone matrix.
authors.affiliation: Division of Oral and Maxillofacial Biology, Matsumoto Dental University Institute for Dental Science, Shiojiri, Japan. kawakami@po.mdu.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: A
authors.initials: A
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Tsujigiwa
authors.forename: M
authors.initials: M
authors.lastname: Gunduz
authors.forename: H
authors.initials: H
authors.lastname: Nagatsuka
authors.forename: N
authors.initials: N
authors.lastname: Nagai
mesh_terms: D000818:Animals; D001846:Bone Development / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000502:physiology*; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D024042:Collagen Type I; D012333:RNA, Messenger