title: Primary malignant lymphoma of the saphenous vein.
abstract: We herein present a case of primary malignant lymphoma of the saphenous vein. A 72-year-old man suffered from tumor and pain of the anteromedial aspect of the left upper thigh. Local thigh ultrasound scanning and computed tomography revealed a mass within the superior third of the internal saphenous vein. The patient underwent surgical exploration and removal of the saphenous vein between the groin and the upper third of the leg. The resected vessel was surrounded and infiltrated by a whitish, rubbery tissue all along its course. The histologic findings were consistent with high-grade, diffuse, large-cell lymphoma of peripheral B lymphocyte origin, primarily arising in the saphenous vein. Antiactin monoclonal antibodies depicted the venous vascular wall infiltrated by tumor cells, confirming the lymphomatous localization within the saphenous vein. The patient is now alive and free of tumor 10 months after the operation.
authors.affiliation: Department of Surgery, Tor Vergata University of Rome, c/o Complesso Integrato Columbus, via Muscati 1, 00168 Rome, Italy. rulli@med.uniroma2.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Rulli
authors.forename: Anna
authors.initials: A
authors.lastname: Neri
authors.forename: Giulio
authors.initials: G
authors.lastname: Bigotti
authors.forename: Raffaele
authors.initials: R
authors.lastname: Tartaglione
authors.forename: Giampiero Ausili
authors.initials: GA
authors.lastname: Cefaro
authors.forename: Attilio Maria
authors.initials: AM
authors.lastname: Farinon
mesh_terms: D000368:Aged; D019337:Hematologic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D011859:Radiography; D012501:Saphenous Vein / Q000000981:diagnostic imaging* / Q000601:surgery; D014463:Ultrasonography