[Postprandial triglyceridemia and carotid atherosclerosis in male patients with coronary heart disease].
OBJECTIVE
To test the effect of postprandial accumulation of triglyceride-rich lipoprotein (TGRL) on carotid artery atherosclerosis.


METHODS
In 42 male cases with coronary heart disease (CHD) as verified by angiography, high density lipoprotein cholesterol and apolipoprotein B (ApoB) levels in fasting serum, serum triglyceride concentrations before and 2, 4, 6, 8 hours after a standard fat test meal were measured. Each patient underwent a carotid artery high-resolution B-mode ultrasound examination. The extent of alimentary lipemia [area under the triglyceride curve over 8 hours, TG-AUC and peak triglyceride response (TGPR)] correlated with the carotid artery intima-media thickness.


RESULTS
Univariate analyses indicated both TG-AUC and TGPR had direct correlation with mean intima-media thickness measured from four well-defined vessel wall segments in the left and right carotid arteries (r = 0.45 and 0.41, both P < 0.01). After controlling for age, body mass index (BMI), triglyceride, HDL-C, and apolipoprotein B concentrations in fasting serum with multivariate stepwise regression analysis, the above correlation remained. There was an independent inverse correlation between HDL-C and carotid artery intima-media thickness.


CONCLUSIONS
It is suggested that abnormal metabolism and clearance of postprandial TGRL can promote the progression of atherosclerosis.
Zhang
Y
Y
Department of Cardiology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730.
Jiang
Y
Y
Shen
J
J
You
K
K
Zhu
W
W
Fang
Q
Q
D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000097:blood* / Q000000981:diagnostic imaging; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood*; D014463:Ultrasonography
D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D014280:Triglycerides