title: Epigenetic reprogramming: how now, cloned cow?
abstract: DNA methylation patterns are dynamic in cleavage-stage embryos of a number of mammalian species. A failure to properly recapitulate preimplantation DNA methylation patterns in embryos derived by nuclear transfer may contribute to the low efficiency of nuclear transfer in producing live offspring.
authors.affiliation: Division of Gene Expression and Development, Roslin Institute, EH25 9PS, Roslin, UK.
authors.forename: Hannah R
authors.initials: HR
authors.lastname: Fairburn
authors.forename: Lorraine E
authors.initials: LE
authors.lastname: Young
authors.forename: Brian D
authors.initials: BD
authors.lastname: Hendrich
mesh_terms: D000818:Animals; D002417:Cattle; D019976:Cloning, Organism; D019175:DNA Methylation; D004622:Embryo, Mammalian / Q000378:metabolism; D005314:Embryonic and Fetal Development