title: On the detection of linkage in multiple data sets: a comparison of various statistical approaches.
abstract: We contrast the pooling of multiple data sets with the compound HLOD (HLOD-C) and the posterior probability of linkage (PPL), two approaches that have been shown to have more power in the presence of genetic heterogeneity. We also propose and evaluate several multipoint extensions.
authors.affiliation: Genome Therapeutics Corporation, 100 Beaver Street, Waltham, MA 02453, USA.
authors.forename: P
authors.initials: P
authors.lastname: Van Eerdewegh
authors.forename: M
authors.initials: M
authors.lastname: Dowd
authors.forename: J
authors.initials: J
authors.lastname: Dupuis
authors.forename: K
authors.initials: K
authors.lastname: Falls
authors.forename: B
authors.initials: B
authors.lastname: Hayward
authors.forename: S L
authors.initials: SL
authors.lastname: Santangelo
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002878:Chromosomes, Human, Pair 1; D002889:Chromosomes, Human, Pair 2; D002896:Chromosomes, Human, Pair 6; D005260:Female; D018740:Genetic Heterogeneity; D005828:Genetics, Population; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D011336:Probability; D018709:Statistics, Nonparametric