title: [Comparison of GCF biochemical components changes during orthodontic tooth movement between children and adults].
abstract: OBJECTIVE
  To study the changes of biochemical components in GCF between children and adults during orthodontic tooth movement.
  
  
  METHODS
  84 patients (child group: 43 subjects, adult group: 41 subjects) were included, each having one treatment tooth and one contralateral control tooth. The levels of PGE2, IL-6 and GM-CSF in GCF of upper lateral incisor were investigated before activation and at 24th hour after the applying of labial orthodontic force, by using of highly sensitive radioimmunoassay.
  
  
  RESULTS
  PGE2, IL-6 and GM-CSF were highly detectable in GCF (> 90%). At experimental sides, total amount of GCF PGE2, IL-6 and GM-CSF levels was significantly elevated at 24th hour compared with that before activation in both child group and adult group. Mean concentration of PGE2 in GCF increased significantly at 24th hour in the two groups, while that of IL-6 and GM-CSF did only in child group. The levels of PGE2, IL-6 and GM-CSF in GCF remained at baseline throughout the study for the control teeth.
  
  
  CONCLUSIONS
  There were some differences of GCF cytokine changes between child and adult groups.
authors.affiliation: Department of Orthodontics, Peking University School of Stomatology, Beijing 100081, China.
authors.forename: D
authors.initials: D
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Ren
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D016207:Cytokines / Q000032:analysis*; D015232:Dinoprostone / Q000032:analysis; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000032:analysis; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D009971:Orthodontics, Corrective; D014087:Tooth Movement Techniques
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D015232:Dinoprostone