[Clinical study on zhenjian granule in improving essential hypertension and insulin resistance].
OBJECTIVE
To observe the effect of Zhenjian granule (ZJG) on lowering the blood pressure and improving the essential hypertension (EH) and insulin resistance (IR).


METHODS
Fifty-two hypertensive patients were randomly divided into the treated group (30 patients) with ZJG and the control group (22 patients) with captopril for 4 weeks, then the variation of levels of blood pressure, blood glucose, blood insulin (radioimmunoassay), insulin sensitivity index (ISI) and blood lipid before and after treatment were determined, and compared with the normal group (17 healthy subjects).


RESULTS
Fasting insulin, blood glucose and insulin 2 hours after meal were significantly higher than those of the normal control, but the ISI was significantly lower than that of the normal control (P < 0.01), the insulin resistance existed; after treatment, not only the blood pressure obviously lowered (P < 0.05, P < 0.01), and the fasting insulin, blood glucose and insulin 2 hours after meal obviously lowered (P < 0.05, P < 0.01), ISI markedly raised (P < 0.05, P < 0.01). The IR of both groups was improved, the blood lipid of the treated group was also improved.


CONCLUSIONS
ZJG was effective in reducing blood pressure, it also had significant effect on improving metabolic disorder, particularly on IR in EH patients.
Tang
S
S
Cardiovascular Department, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing (210029).
Jiang
W
W
Chen
X
X
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D002216:Captopril / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007328:Insulin; D002216:Captopril