Ketamine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices is mediated not only via NMDA receptors but also via sigma receptors.
Ketamine induces marked c-fos expression in the posterior cingulate and retrosplenial cortices (PC/RS). We investigated whether NMDA and/or sigma receptors were involved in the c-Fos expression. The number of Fos-LI positive boutons in NMDA receptor knockout mice was significantly lower than that in wild-type mice. Rimcazole but not haloperidol significantly suppressed the c-Fos expression. The results indicate that the ketamine-induced c-Fos expression is mediated not only via NMDA receptors but also via sigma receptors.
Nakao
Shinichi
S
Department of Anesthesiology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-shi, Osaka, Japan. nakaos@takii.kmu.ac.jp
Miyamoto
Etsuko
E
Masuzawa
Munehiro
M
Kambara
Tomoko
T
Shingu
Koh
K
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002227:Carbazoles / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006179:Gyrus Cinguli / Q000187:drug effects / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D017729:Presynaptic Terminals / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism*; D017480:Receptors, sigma / Q000378:metabolism*
D000927:Anticonvulsants; D002227:Carbazoles; D018492:Dopamine Antagonists; D018691:Excitatory Amino Acid Antagonists; D016760:Proto-Oncogene Proteins c-fos; D016194:Receptors, N-Methyl-D-Aspartate; D017480:Receptors, sigma; D007649:Ketamine; C034931:rimcazole; D006220:Haloperidol