Characterization of the murine gene for subunit VIIaL of cytochrome c oxidase.
Mammalian cytochrome c oxidase consists of thirteen subunits, ten encoded by the nuclear genome and three by the mitochondrial DNA. In several species, two isoforms have been isolated for nuclear-encoded subunits VIa, VIIa and VIII: an ubiquitous L (liver) form and a heart- and skeletal-muscle specific H form. The gene for murine cytochrome c oxidase subunit VIIa-L (Cox7aL) and its promoter region were isolated, sequenced and analysed. The coding region is split in four exons spanning 4.1 kbp and the promoter carries potential binding sites for Sp1, NRF1 and NRF2 transcription factors. Transcriptional activity of the promoter in reporter assays suggested an ubiquitous expression in mouse tissues.
Chantrel-Groussard
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UMR CNRS 6101, 2, rue du Docteur Marcland, 87025 Limoges, France.
Delpy
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Ratinaud
M H
MH
Cogné
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D000818:Animals; D001483:Base Sequence; D003576:Electron Transport Complex IV / Q000235:genetics*; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D008969:Molecular Sequence Data; D021122:Protein Subunits; D015183:Restriction Mapping; D014157:Transcription Factors / Q000378:metabolism
D021122:Protein Subunits; D014157:Transcription Factors; D003576:Electron Transport Complex IV