Work-up strategies for high-throughput solution synthesis.
The key bottleneck in parallel synthesis has, in truth, always been the isolation and purification of the reaction products, rather than carrying out the reactions themselves. Solution-phase chemistry for parallel synthesis has recently been re-emphasized and has stimulated the development of a wide-range of practical tools for efficient high-throughput work-up, which are gaining increasing acceptance in medicinal chemistry groups.
Cork
David
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Takeda Chemical Industries, Medicinal Chemistry Research, Laboratories I, Pharmaceutical Research Division 17-85 Juso-Honmachi 2-ChomeYodogawa-Ku, Osaka, 532-8686, Japan.
Hird
Nick
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D001331:Automation; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000458:organization & administration; D005374:Filtration; D012117:Resins, Synthetic / Q000737:chemistry; D012996:Solutions
D012117:Resins, Synthetic; D012996:Solutions