Human recombinant activated protein C in meningococcal sepsis.
A 19-year-old woman presented with purpura fulminans and septic shock; subsequently, progressive coagulopathy, widespread purpura fulminans associated with meningococcemia, severe shock, respiratory, and renal failure developed. This clinical course was associated with depletion of functional protein C levels to < 5%. We describe her clinical course and therapy with human recombinant activated protein C.
Wcisel
Gregory
G
Department of Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA.
Joyce
David
D
Gudmundsdottir
Arna
A
Shasby
D Michael
DM
D000328:Adult; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D011486:Protein C / Q000008:administration & dosage*; D020151:Protein C Deficiency / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage; D014884:Waterhouse-Friderichsen Syndrome / Q000188:drug therapy*
D011486:Protein C; D011994:Recombinant Proteins