title: Leishmania major promastigotes inhibit dendritic cell motility in vitro.
abstract: Using an in vitro transwell migration assay, we have demonstrated that products secreted by Leishmania major promastigotes inhibit the motility of dendritic cells (DC) by up to 93%. Inhibition was dose dependent and reversible. By inhibiting DC migration in vivo, L. major may therefore subvert DC from their potentially protective role during leishmaniasis.
authors.affiliation: Antigen Presentation Research Group, Department of Immunology, Imperial College School of Medicine, Northwick Park Hospital, Harrow, London HA1 3UJ, United Kingdom. hjebbari@yahoo.co.uk
authors.forename: Heather
authors.initials: H
authors.lastname: Jebbari
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Stagg
authors.forename: Robert N
authors.initials: RN
authors.lastname: Davidson
authors.forename: Stella C
authors.initials: SC
authors.lastname: Knight
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D003713:Dendritic Cells / Q000469:parasitology* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D018320:Leishmania major / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology
chemical_list: D017077:Culture Media, Conditioned