title: Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study.
abstract: SKI 306X is a purified extract from a mixture of three oriental herbal medicines (Clematis mandshurica, Trichosanthes kirilowii and Prunella vulgaris) that have been widely used for the treatment of inflammatory diseases such as lymphadenitis and arthritis in far East Asia. A double-blind, controlled study was performed to evaluate the efficacy and safety of SKI 306X with placebo in 96 patients with classical osteoarthritis of the knee. Patients were randomized to four treatment groups: placebo, 200 mg, 400 mg and 600 mg of SKI 306X t.i.d.. Clinical efficacy and safety were evaluated for 4 weeks continuous treatment. SKI 306X demonstrated its clinical efficacy, as assessed by 100 mm visual analogue scale (VAS), Lequesne index and patients' and investigators opinion of the therapeutic effect compared with placebo (p<0.01). No significant adverse events were observed in patients treated with SKI 306X. This study demonstrated that SKI 306X, a new herbal anti-arthritic agent provided clinical efficacy in patients with osteoarthritis.
authors.affiliation: Department of Orthopaedic Surgery, Yongsan Hospital, Chung-Ang University, Yongsan-Ku, Seoul, Korea.
authors.forename: Y B
authors.initials: YB
authors.lastname: Jung
authors.forename: K J
authors.initials: KJ
authors.lastname: Roh
authors.forename: J A
authors.initials: JA
authors.lastname: Jung
authors.forename: K
authors.initials: K
authors.lastname: Jung
authors.forename: H
authors.initials: H
authors.lastname: Yoo
authors.forename: Y B
authors.initials: YB
authors.lastname: Cho
authors.forename: W J
authors.initials: WJ
authors.lastname: Kwak
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Kim
authors.forename: C K
authors.initials: CK
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003257:Consumer Product Safety; D004311:Double-Blind Method; D004361:Drug Tolerance; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D019686:Lamiaceae; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy* / Q000503:physiopathology; D029626:Ranunculaceae; D016896:Treatment Outcome; D029778:Trichosanthes
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C460104:SKI 306X