A cytotoxic secocycloartenoid from Abies koreana.
Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9beta-lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with beta-sitosterol (2), maltol (3), beta-sitosterol-O-beta-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.
Kim
H J
HJ
Colleges of Pharmacy, Chonnam National University, Kwangju, Korea.
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Q K
QK
Lee
M H
MH
Kim
T S
TS
Lee
H K
HK
Kim
Y H
YH
Bae
K
K
Lee
I S
IS
D028202:Abies / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C457235:24-methylene-3,4-secocycloart-4(28)-en-3-oic acid; C457236:3-oxolanosta-7,22,24-trien-26,23-olide; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes