title: Strategy for hepatoblastoma management: Transplant versus nontransplant surgery.
abstract: BACKGROUND
  Liver transplantation now is proposed for managing selected hepatoblastoma cases. Indications are not yet well defined.
  
  
  METHODS
  The case records of 34 children with hepatoblastoma treated over a period of 10 years (1991 to 2000) were reviewed retrospectively.
  
  
  RESULTS
  All patients benefited from preoperative chemotherapy. Twenty patients underwent major hepatic resections. Twelve patients, in absence of residual metastasis, underwent liver transplant because the tumour remained unresectable after chemotherapy. Two patients who presented with recurrence after a right hepatectomy, benefited from transplant as a second option. Two other patients did not undergo surgery because of widespread disease or resistance to chemotherapy. Disease-free survival rates were 95% after surgical resection, 100% when primary transplant was performed in patients with good response to chemotherapy, 60% after transplantation in patients with poor response to chemotherapy, 50% in patients with transplant as second option, and 0% in patients not undergoing surgery.
  
  
  CONCLUSIONS
  Transplantation is a potentially curative option for unresectable hepatoblastoma when chemosensitive (decrease in alpha-fetoprotein and decrease in tumour size). In this context, also favourable cases with good response but difficult resections with doubtful margins of resection may best be proposed for primary transplantation. Patients with recurrent or resistant disease are not good candidates.
authors.affiliation: Birmingham, England.
authors.forename: A P
authors.initials: AP
authors.lastname: Pimpalwar
authors.forename: K
authors.initials: K
authors.lastname: Sharif
authors.forename: P
authors.initials: P
authors.lastname: Ramani
authors.forename: M
authors.initials: M
authors.lastname: Stevens
authors.forename: R
authors.initials: R
authors.lastname: Grundy
authors.forename: B
authors.initials: B
authors.lastname: Morland
authors.forename: C
authors.initials: C
authors.lastname: Lloyd
authors.forename: D A
authors.initials: DA
authors.lastname: Kelly
authors.forename: J A
authors.initials: JA
authors.lastname: Buckles
authors.forename: J
authors.initials: J
authors.lastname: de Ville De Goyet
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D018197:Hepatoblastoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000188:drug therapy / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents