Carbohydrate-induced hypertriglyceridemia: modifying factors and implications for cardiovascular risk.
High-carbohydrate/low-fat, isocaloric diets have repeatedly been shown to increase plasma triglyceride concentrations. The present review addresses recent developments relevant to several important unresolved issues. These include the type of dietary carbohydrate that is most likely to induce hypertriglyceridemia, predictors of individual susceptibility, modifiable physiologic factors that may mitigate the plasma triglyceride response, underlying metabolic mechanisms that are responsible for increased plasma triglycerides, and implications of altered serum lipid profiles for atherogenic risk. Although some progress has been made in this field, the central public health issue - the net effect on cardiovascular risk - remains unresolved.
Hellerstein
Marc K
MK
Department of Nutritional Sciences and Toxicology, University of California at Berkeley, California 94720-3104, USA. march@nature.berkeley.edu
D001161:Arteriosclerosis / Q000453:epidemiology* / Q000503:physiopathology; D001835:Body Weight / Q000502:physiology; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D004198:Disease Susceptibility / Q000378:metabolism*; D015444:Exercise / Q000502:physiology; D005260:Female; D005632:Fructose / Q000009:adverse effects; D020022:Genetic Predisposition to Disease; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D012307:Risk Factors
D004040:Dietary Carbohydrates; D005632:Fructose