[Treatment of malignant pleural effusion using vindesine and cisplatine intrapleurally injection (observation of 60 cases)].
OBJECTIVE
To evaluate the efficacy of treating malignant pleural effusion with cisplatine and vindesine by injection through thoracic tube intubation.


METHODS
60 cases with malignant pleural effusion, after drainage, vindesine 4 mg, cisplatine 40 mg/m(2) were injectred into pleural cavity in therapy group (T), and only cisplatine 40 mg/m(2) in control group (C). the tretment was repeated after a week, then evaluate the efficacy, survival rate, toxicities and quality of life.


RESULTS
The response rate was 81% in T group and 50% in C group. There was statistical difference in two groups (P < 0.05). The Karnofsky score is higher in T group than in C group. The half-year, one-year, one and half-year, two-year survival rates were 97%, 59%, 44%, 6% in T group and 71%, 50%, 14%, 4% in C group. Grade I leukopenia is higher in T group than in C group.


CONCLUSIONS
The treatment to use Vindesine and cisplatine through thoracic tube is regarded as effective, slight side-effect and well tolerated method for malignant pleural effusion.
Zhang
Z
Z
Department Oncology Shanghai Pneumology Hospital, Shanghai 200433, China.
Li
D
D
Wu
Z
Z
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004333:Drug Administration Routes; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D014751:Vindesine / Q000008:administration & dosage
D002945:Cisplatin; D014751:Vindesine