T cell immunotherapeutic populations control viral infections in bone marrow transplant recipients.
Immunotherapies designed to prevent infection serve as an increasingly important adjunct to bone marrow transplantation (BMT). T cell immunotherapies are particularly useful for the control of virus infections, provided that T cell populations are free of graft-vs-host (GVH) activity. In this review, we describe positive and negative selection methods with which donor T cell populations devoid of GVH activity can be prepared for transfer to the immunodeficient BMT recipient. The support of patients with T cell immunotherapies may ultimately revolutionize BMT, elevating the procedure from a salvage to a front-line treatment strategy for otherwise fatal disorders.
Slobod
K S
KS
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Benaim
E
E
Woodruff
L
L
Nooner
S
S
Houston
J
J
Holladay
M
M
Lockey
T
T
Hurwitz
J L
JL
D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D002469:Cell Separation; D020031:Epstein-Barr Virus Infections / Q000209:etiology / Q000276:immunology / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D016219:Immunotherapy, Adoptive / Q000379:methods; D066298:In Vitro Techniques; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014777:Virus Diseases / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*