An efficient and versatile synthesis of acylpolyamine spider toxins.
An efficient and versatile synthesis of acylpolyamine spider toxins was developed based on the structural classification of the Nephila and Nephilengys spider toxins using the 2-nitrobenzenesulfonamide protecting group. The naturally occurring toxins 1-5 representing each structural type have been efficiently synthesized by this method in a high overall yield with few steps.
Nihei
Ken-ichi
K
Institute of Chemistry, University of São Paulo, São Paulo, SP 05508-900, Brazil.
Kato
Massuo J
MJ
Yamane
Tetsuo
T
Palma
Mario S
MS
Konno
Katsuhiro
K
D000818:Animals; D015317:Biogenic Polyamines / Q000138:chemical synthesis*; D002853:Chromatography, Liquid; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry; D013111:Spider Venoms / Q000138:chemical synthesis*; D013112:Spiders; D013329:Structure-Activity Relationship
D015317:Biogenic Polyamines; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; C426070:JSTX-3; D011073:Polyamines; D013111:Spider Venoms