[Observation on dynamic changes of serum procollagen III, hyaluronic acid and laminin in rats with hepatic fibrosis treated with Hujin pill].
OBJECTIVE
To study the dynamic changes of serum procollagen III (PCIII), hyaluronic acid (HA) and laminin (LN) in rats with hepatic fibrosis treated with Hujin pill (HJP).


METHODS
The classic model of hepatic fibrosis induced by CCl4 were used in the observation. The serum PCIII, HA and LN were determined by radioimmunoassay (RIA).


RESULTS
HJP could reduce the serum HA, LN content significantly, as compared with the control group, the difference was significant (P < 0.05, P < 0.01). Its long-term therapeutic effect was better than that of colchicine. It could maintain the serum PCIII stable in hepato-fibrotic stage (9-12 weeks), as compared with the normal control group, the difference was insignificant (P > 0.05).


CONCLUSIONS
HJP could retard the liver fibrosis, and has good preventive and therapeutic effect on liver fibrosis in rats.
Huang
Z
Z
College of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou (510405).
Li
Q
Q
Wang
Z
Z
D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008517:Phytotherapy; D011347:Procollagen / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D007797:Laminin; D011347:Procollagen; D006820:Hyaluronic Acid