title: Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to acyclic aliphatic enones.
abstract: Cu-catalyzed enantioselective conjugate additions to acyclic aliphatic enones are reported. The resulting enolates may be functionalized intra- and intermolecularly, leading to the formation of an additional C-C bond. The utility of the present method is not limited to reactions involving Et2Zn; a variety of alkylzincs may be used. Moreover, many of the requisite substrates can be easily accessed through catalytic olefin cross metathesis.
authors.affiliation: Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.
authors.forename: Hirotake
authors.initials: H
authors.lastname: Mizutani
authors.forename: Sylvia J
authors.initials: SJ
authors.lastname: Degrado
authors.forename: Amir H
authors.initials: AH
authors.lastname: Hoveyda