7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
Buckley
George M
GM
Celltech R & D, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
Cooper
Nicola
N
Davenport
Richard J
RJ
Dyke
Hazel J
HJ
Galleway
Fiona P
FP
Gowers
Lewis
L
Haughan
Alan F
AF
Kendall
Hannah J
HJ
Lowe
Christopher
C
Montana
John G
JG
Oxford
Janet
J
Peake
Joanna C
JC
Picken
C Louise
CL
Richard
Marianna D
MD
Sabin
Verity
V
Sharpe
Andrew
A
Warneck
Julie B H
JB
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001665:Binding Sites; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D005663:Furans / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D006168:Guinea Pigs; D007202:Indicators and Reagents; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D020889:Rolipram / Q000378:metabolism; D013329:Structure-Activity Relationship
D018927:Anti-Asthmatic Agents; D005663:Furans; D007202:Indicators and Reagents; D010726:Phosphodiesterase Inhibitors; D011725:Pyridines; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram