Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes.
Progression of resting quiescent G(0) cells into early G(1) and transition across the restriction point are highly regulated processes. Mutation of proto-oncogenes and tumor suppressor genes regulating these transitions are targeted during oncogenesis. Recent work has underscored the importance of the G(0) to early G(1) transition and metabolism to neoplastic cells.
Ho
Alan
A
Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, UCSD, 9500 Gilman Drive, La Jolla, California 92093-0686, USA.
Dowdy
Steven F
SF
D000818:Animals; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors; D016213:Cyclins / Q000378:metabolism; D016193:G1 Phase; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes / Q000502:physiology*; D016192:Resting Phase, Cell Cycle; D016160:Retinoblastoma Protein / Q000378:metabolism; D014158:Transcription, Genetic
D016213:Cyclins; D016160:Retinoblastoma Protein; D018844:Cyclin-Dependent Kinases