Genome scan for linkage to asthma using a linkage disequilibrium-lod score test.
We report a genome-wide linkage study of asthma on the German and Collaborative Study on the Genetics of Asthma (CSGA) data. Using a combined linkage and linkage disequilibrium test and the nonparametric linkage score, we identified 13 markers from the German data, 1 marker from the African American (CSGA) data, and 7 markers from the Caucasian (CSGA) data in which the p-values ranged between 0.0001 and 0.0100. From our analysis and taking into account previous published linkage studies of asthma, we suggest that three regions in chromosome 5 (around D5S418, D5S644, and D5S422), one region in chromosome 6 (around three neighboring markers D6S1281, D6S291, and D6S1019), one region in chromosome 11 (around D11S2362), and two regions in chromosome 12 (around D12S351 and D12S324) especially merit further investigation.
Jiang
Y
Y
Department of Statistics and Actuarial Science, 241 Schaeffer Hall, University of Iowa, Iowa City, IA 52242, USA.
Slager
S L
SL
Huang
J
J
D000328:Adult; D001249:Asthma / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005828:Genetics, Population; D005858:Germany; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D014481:United States
D005819:Genetic Markers