[Bioavailability of three brands of omeprazole capsule and their effects on 24 hour intragastric pH in healthy volunteers].
OBJECTIVE
To compare the bioavailability of three brands of omeprazole capsule (Losec, Aoke-Changzhou No.4 Pharm, Omeprazole-Sanye Pharm) and their effects on 24 hour intragastric pH in healthy volunteers.


METHODS
With crossover design (washout period of 7 days), 18 healthy volunteers (12 men, 6 women) were randomly divided into three groups. Each subject was given the three different brands of omeprazole capsule 40 mg respectively.


RESULTS
The pharmacokinetic study revealed that Losec had an advantage over other two brands of omeprazole capsule in that it was absorbed more rapidly and to a greater extent, resulting in higher plasma concentration and longer staying time in blood. It also showed the shortest latent time in elevating intragastric pH (2.53 hours), the largest net increment in mean gastric pH (3.37), and the greatest prolongation of time with pH > 4 (15.3 hours) among the three products.


CONCLUSIONS
The three brands of omeprazole capsule are significantly different with respect to their pharmacokinetic process and effects on 24 hour intragastric pH profile. Losec is superior to other two brands of omeprazole capsule in view of its better bioavailability, quicker onset of action, more potent and lasting antisecretory effect.
Dong
H
H
Medical Technology Assessment and Research Center, Shanghai Medical University. Shanghai 200032.
D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D002214:Capsules; D018592:Cross-Over Studies; D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000897:Anti-Ulcer Agents; D002214:Capsules; D009853:Omeprazole