[Study on relationship of parameters of nitric oxide, endothelin and blood stasis syndrome in traditional Chinese medicine in acute cerebral infarction].
OBJECTIVE
To explore the relationship of parameters of nitric oxide (NO), endothelin (ET) and blood stasis syndrome (BSS) of traditional Chinese medicine (TCM) in acute cerebral infarction (ACI).


METHODS
Seventy-three patients of ACI (ACI group) were divided into two groups by the score of BSS: BSS group (included 18 cases of serious BSS, 19 cases of moderate BSS, and 21 cases of mild BSS); and non-BSS group (15 cases); while 30 healthy subjects were taken as the control group, their NO and ET were determined.


RESULTS
Compared with the control group, the level of ET and ratio of ET/NO raised significantly in the ACI group and the BSS group (P < 0.01). The levels of ET and ratio of ET/NO of mild, moderate and serious BSS increased in order, but only the serious BSS in comparing with mild, moderate group of BSS had significant difference (P < 0.01). The NO levels of ACI group, non-BSS group in comparing with healthy control, there was significant decrease (P < 0.05, P < 0.01). The NO concentration among the mild, moderate and serious group of BSS had insignificant difference (P > 0.05).


CONCLUSIONS
NO and ET participates the formation and development of ACI, owing to the disturbed NO and ET secretion by vascular, nerve cells etc., these might be the pathologic basis of BSS occurrence.
Yu
Y
Y
Department of Neurology, Fujian Provincial People's Hospital, Fuzhou (350004).
Liang
H
H
Huang
J
J
D000208:Acute Disease; D000368:Aged; D002544:Cerebral Infarction / Q000097:blood*; D003937:Diagnosis, Differential; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*
D016232:Endothelins; D009569:Nitric Oxide