[The role of chemotherapy in the treatment of non-metastatic, non-small cell bronchial cancers].
A systematic review of the literature about the role of chemotherapy in comparison to local therapies--surgery or radiotherapy--in non-small cells lung cancers has identified 35 randomised trials. The methodological assessment has not shown significant difference for quality scores between negative or positive studies in term of survival effect. The aggregation (meta-analysis) shows a significant effect of survival improvement by chemotherapy, whatever all indications are considered or subgroups like adjuvant chemotherapy to surgery, neoadjuvant chemotherapy, concomitant radio-chemotherapy and induction chemotherapy prior to thoracic irradiation.
Sculier
J P
JP
Département de Médecine Interne et Laboratoire d'Investigation Clinique H.J. Tagnon, Institut Jules Bordet, Centre des Tumeurs de l'U.L.B. Lille.
Berghmans
T
T
Paesmans
M
M
Branle
F
F
Lemaitre
F
F
Mascaux
C
C
Meert
A P
AP
Steels
E
E
Vallot
F
F
Lafitte
J J
JJ
D001530:Belgium / Q000453:epidemiology; D002283:Carcinoma, Bronchogenic / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D020360:Neoadjuvant Therapy / Q000379:methods / Q000592:standards; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000592:standards; D018714:Radiotherapy, Adjuvant / Q000592:standards; D012107:Research Design / Q000592:standards; D016019:Survival Analysis; D016896:Treatment Outcome