Rapid direct determination of pesticides and metabolites in environmental water samples at sub-microg/l level by on-line solid-phase extraction-liquid chromatography-electrospray tandem mass spectrometry.
A very rapid, multi-residual, sensitive and specific procedure for determining 35 pesticides in environmental ground and surface water in proposed. It is based on the use of solid-phase extraction (SPE) combined on-line with liquid chromatography (LC) electrospray (ESI) tandem mass spectrometry (MS-MS). Simultaneous target analysis of 29 pesticides (1 fungicide, 16 insecticides, 10 herbicides and 2 acaricides) and 6 metabolites with positive or negative ionization was reached by the direct injection of only 1.3 ml of filtered water sample, with a total analysis time of 18 min. The SPE-LC-MS-MS method was validated, obtaining good results for all compounds at 0.5 and 0.1 microg/l. Most of them could be correctly quantified at a concentration level as low as 25 ng/l. Efficiency and applicability of this method was evaluated by the analysis of several samples included in a monitoring program.
Hernández
F
F
Analytical Chemistry, Experimental Sciences Department, University Jaume I, Castellón, Spain. hernandf@exp.uji.es
Sancho
J V
JV
Pozo
O
O
Lara
A
A
Pitarch
E
E
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004784:Environmental Monitoring; D010575:Pesticides / Q000032:analysis* / Q000378:metabolism; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis*
D010575:Pesticides; D014874:Water Pollutants, Chemical