Functional conservation of hematopoietic factors in Drosophila and vertebrates.
The GATA, Friend of GATA, and Runt homology domain protein families function during hematopoiesis to promote progenitor cell development and regulate lineage commitment and differentiation. The hematopoietic functions of these factors have been remarkably conserved across taxonomic groups, ranging from flies to humans. Furthermore, aspects of hematopoiesis and hemocyte function appear to be conserved. Thus, comparative studies using Drosophila and vertebrate models should enhance our understanding of blood cell development.
Fossett
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Department of Biochemistry and Molecular Biology, Graduate Program in Genes & Development, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. nfossett@odin.mdacc.tmc.edu
Schulz
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RA
D000818:Animals; D005075:Biological Evolution; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D050676:Core Binding Factor Alpha 2 Subunit; D050677:Core Binding Factor Alpha 3 Subunit; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D004330:Drosophila / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006434:Hemocytes / Q000502:physiology; D051379:Mice; D009363:Neoplasm Proteins; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D011518:Proto-Oncogene Proteins; D026801:Synteny; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D014714:Vertebrates / Q000502:physiology*
D002352:Carrier Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D050677:Core Binding Factor Alpha 3 Subunit; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; C493730:Runx3 protein, mouse; D014157:Transcription Factors; C107310:Zfpm1 protein, mouse