[Gamma-glutamyltranspeptidase (gamma-GT)].
gamma-GT is a membrane-bound enzyme which plays a role in the metabolism of glutathione and facilitates amino-acid transport. gamma-GT is located in several tissues such as the kidney, pancreas and liver. Serum gamma-GT activity is induced by hepatobiliary diseases, especially alcoholic liver diseases and cholestasis, not by renal diseases. Isoenzymes specific for hepatocellular carcinoma are demonstrated by electrophoresis. A new method of measuring serum gamma-GT specific for hepatocellular carcinoma was recently reported.
Ohata
M
M
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine.
Toda
G
G
D000818:Animals; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular; D004796:Clinical Enzyme Tests / Q000379:methods; D004586:Electrophoresis; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008107:Liver Diseases / Q000175:diagnosis; D008113:Liver Neoplasms / Q000175:diagnosis; D005723:gamma-Glutamyltransferase / Q000097:blood* / Q000235:genetics
D015415:Biomarkers; D007527:Isoenzymes; D005723:gamma-Glutamyltransferase