[Treatment of dyskinetic disorders with tremor by lesioning and DBS of Vim].
OBJECTIVE
To explore the effect of stereotactic operation in treatment of dyskinetic disorders with tremor as the main symptom and to study the value of anatomic location and microelectrode functional location.


METHODS
Surgiplan system and microelectrode direction technique were used to locate the Vim, and then target lesioning and deep brain simulation (DBS) were performed in 22 patients with dyskinetic disorders with tremor. After the operation, a follow-up was conducted for 6 approximately 12 months.


RESULTS
After the operation, tremor disappeared in 21 patients and hypermyotonia was improved in 13 cases. During the follow-up tremor completely disappeared in 18 patients, including 3 cases treated with DBS, was markedly alleviated in 3 cases and was slightly improved in one case. Typical cell firing at tremor was recorded in 17 cases during the operation.


CONCLUSIONS
The surgiplan system and microelectrode recording technique play an important role in location of Vim. Accurate location is crucial for success of operation. The curative effect of DBS is similar as lesioning operation.
Zhang
J
J
Department of Neurosurgery, Tiantan Hospital, Beijing 100050, China.
Wang
Z
Z
Zhang
X
X
D000328:Adult; D000368:Aged; D020820:Dyskinesias / Q000150:complications / Q000628:therapy*; D004599:Electric Stimulation Therapy / Q000379:methods*; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000628:therapy; D013787:Thalamic Nuclei / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D014202:Tremor / Q000209:etiology / Q000628:therapy*