Protective effect of ajoene on acetaminophen-induced hepatic injury in mice.
Ajoene, a garlic-derived sulfur-containing compound, exhibited a hepatoprotective effect against acetaminophen-induced liver injury in mice. A pretreatment with ajoene suppressed the rise in serum glutamic-pyruvic transaminase activity and the reduction in the hepatic reduced glutathione level. These effects of ajoene were observed dose-dependently (20-100 mg/kg). The pretreatment by ajoene also suppressed the decrease in hepatic protein thiol content resulting from acetaminophen administration.
Hattori
A
A
Biodevelopment Division, Central Institute, Nagoya Seiraku Co. Ltd., Aichi, Japan.
Yamada
N
N
Nishikawa
T
T
Fukuda
H
H
Fujino
T
T
D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D004220:Disulfides / Q000737:chemistry / Q000494:pharmacology*; D005737:Garlic / Q000737:chemistry; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013454:Sulfoxides
D004220:Disulfides; D010936:Plant Extracts; D013454:Sulfoxides; D000082:Acetaminophen; C048980:ajoene; D000410:Alanine Transaminase; D005978:Glutathione