Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha.
Exquisite regulation is required for cells to properly enter and exit the phases of the cell cycle. The transmembrane receptor-like protein tyrosine phosphatase RPTPalpha, an important protein that participates in the transition of the cell cycle from G2 to mitosis activates the protein tyrosine kinase c-Src in vivo. Mustelin and Hunter discuss new findings that describe the highly regulated activation of RPTPalpha and c-Src that occurs just before entry into the mitotic phase. These findings also raise several questions that pertain to redistribution of RPTPalpha in the cell, and the role of phosphorylation and dimerization in regulating RPTPalpha activity.
Mustelin
Tomas
T
Program of Signal Transduction, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. tmustelin@burnham-inst.org
Hunter
Tony
T
D000818:Animals; D000081247:CSK Tyrosine-Protein Kinase; D002453:Cell Cycle / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D016391:Genes, src / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*; D019000:Phosphotyrosine / Q000737:chemistry / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4; D011956:Receptors, Cell Surface; D019061:src-Family Kinases
D011956:Receptors, Cell Surface; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases; D000081247:CSK Tyrosine-Protein Kinase; D019061:src-Family Kinases; D017027:Protein Tyrosine Phosphatases; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4