[The role of PAR family receptors in activation of mast cells in the norm and in acute inflammation in rats].
Dose-dependent release of beta-hexoaminidase induced with thrombin was shown to be mediated by the PAR-1. This was further confirmed by means of agonist, antagonist and PAR desensitization. Acceleration of the mast cell mediator secretion by the Xa factor and PAR-2 agonist, was revealed. An increase in the mast cell release induced by thrombin and TRAP-6 was shown in the acute peritonitis model.
Kiseleva
E V
EV
M. V. Lomonossov State University, 119899, Vorobievy Gory, Moscow, Russia.
Dugina
T N
TN
Gluza
E
E
Strukova
S M
SM
D000208:Acute Disease; D000818:Animals; D056649:Cathepsin G; D002403:Cathepsins / Q000494:pharmacology; D006636:Histamine Release; D066298:In Vitro Techniques; D008407:Mast Cells / Q000201:enzymology / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology; D010538:Peritonitis / Q000378:metabolism*; D051381:Rats; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012697:Serine Endopeptidases; D013917:Thrombin / Q000494:pharmacology / Q000502:physiology; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
D010446:Peptide Fragments; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin; C082835:thrombin receptor peptide (42-47); D001619:beta-N-Acetylhexosaminidases; D002403:Cathepsins; D012697:Serine Endopeptidases; D056649:Cathepsin G; C534097:Ctsg protein, rat; D013917:Thrombin