title: [Lithogenesis. Towards a new approach].
abstract: OBJECTIVE
  To describe a more general, less restrictive approach to stone formation that takes into account experimental data and to develop a hypothesis of stone formation based on experimental, molecular biology and clinical findings.
  
  
  RESULTS
  Stone formation is reviewed in the light of the authors' findings by means of an appropriate experimental method in an attempt to understand fundamental aspects of urolithiasis. This project, which is currently under discussion, attempts to provide answers to the physiopathological issues of this old disease.
  
  
  CONCLUSIONS
  Observation of the experimental phenomena that result in stone formation constitutes a new approach that can provide further insight into stone formation.
authors.affiliation: Unidad de Litotricia, Servicio de Urología, Hospital Ramón y Cajal, Universidad de Alcalá, Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: García Cuerpo
authors.forename: E
authors.initials: E
authors.lastname: Olavi Kajander
mesh_terms: D006801:Humans; D014545:Urinary Calculi / Q000737:chemistry / Q000209:etiology*