title: Effects of roxithromycin on adhesion molecules expressed on endothelial cells of the dermal microvasculature.
abstract: The objective of the study was to investigate the pharmacological action of roxithromycin, an oral macrolide antibiotic. The effects of roxithromycin on the cytokine-induced expression of endothelial leukocyte adhesion molecule (E-selectin) and intracellular adhesion molecule (ICAM)-1 on endothelial cells of the dermal microvasculature were investigated in vitro using flow cytometry. Roxithromycin at a concentration of 0.5 microgram/ml, which is lower than the therapeutic plasma concentration (ordinary daily dose, 150-300 mg), significantly inhibited the expression of E-selectin and ICAM-1 on endothelial cells of the dermal microvasculature induced by tumour necrosis factor-alpha. We conclude that roxithromycin may exert its anti-inflammatory action by inhibition of the in vivo expression of adhesion molecules on dermal microvascular endothelial cells.
authors.affiliation: Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan. akamatsu@fujita-hu.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Akamatsu
authors.forename: M
authors.initials: M
authors.lastname: Yamawaki
authors.forename: T
authors.initials: T
authors.lastname: Horio
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019040:E-Selectin / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D015575:Roxithromycin / Q000494:pharmacology*; D012867:Skin / Q000098:blood supply*
chemical_list: D000900:Anti-Bacterial Agents; D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1; D015575:Roxithromycin