Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production.
The effect of the macrolide antibiotics, clarithromycin, midecamycin acetate and josamycin, on the generation of Th1- and Th2-type cytokines by mitogen-stimulated human T lymphocytes was compared with that of fosfomycin. The following results were obtained. These drugs demonstrated potent inhibitory activity on the release and gene expression of TNF-alpha and IL-2. Their inhibitory effect on IFN-alpha, IL-4, IL-5, IL-6 was less marked. The release of IL-10 was poorly suppressed. Clarithromycin had the most potent inhibitory effect of the drugs used. The present results suggested that anti-bacterial agents might modify the host's immunological response by interfering with the activity of T helper cells.
Morikawa
K
K
Division of Clinical Nutrition, Department of Nutrition, Sagami Women's University, Bunkyo 2-1-1, Kanagawa 228-8533, Sagamihara, Japan. morikawa_keiko@isc.sagami-wu.ac.jp
Zhang
J
J
Nonaka
M
M
Morikawa
S
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D017291:Clarithromycin / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis*; D005578:Fosfomycin / Q000494:pharmacology; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000235:genetics; D015570:Josamycin / Q000494:pharmacology; D007933:Leucomycins / Q000494:pharmacology; D008213:Lymphocyte Activation; D012333:RNA, Messenger / Q000032:analysis; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics
D000900:Anti-Bacterial Agents; D016207:Cytokines; D007376:Interleukin-2; D007933:Leucomycins; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D005578:Fosfomycin; D017291:Clarithromycin; D015570:Josamycin; C026483:midecamycin