title: Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria.
abstract: Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F(2) intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM.
authors.affiliation: Institute of Science and Technology. Division of Molecular Life Science, School of Medicine. Division of Infectious Diseases, Tokai University, Isehara 259-1193, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Nagayasu
authors.forename: Koichi
authors.initials: K
authors.lastname: Nagakura
authors.forename: Mayumi
authors.initials: M
authors.lastname: Akaki
authors.forename: Gen
authors.initials: G
authors.lastname: Tamiya
authors.forename: Satoshi
authors.initials: S
authors.lastname: Makino
authors.forename: Yamaji
authors.initials: Y
authors.lastname: Nakano
authors.forename: Minoru
authors.initials: M
authors.lastname: Kimura
authors.forename: Masamichi
authors.initials: M
authors.lastname: Aikawa
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D004195:Disease Models, Animal; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D007113:Immunity, Innate / Q000235:genetics; D016779:Malaria, Cerebral / Q000235:genetics* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010641:Phenotype; D010962:Plasmodium berghei / Q000276:immunology*