title: T cell immunotherapeutic populations control viral infections in bone marrow transplant recipients.
abstract: Immunotherapies designed to prevent infection serve as an increasingly important adjunct to bone marrow transplantation (BMT). T cell immunotherapies are particularly useful for the control of virus infections, provided that T cell populations are free of graft-vs-host (GVH) activity. In this review, we describe positive and negative selection methods with which donor T cell populations devoid of GVH activity can be prepared for transfer to the immunodeficient BMT recipient. The support of patients with T cell immunotherapies may ultimately revolutionize BMT, elevating the procedure from a salvage to a front-line treatment strategy for otherwise fatal disorders.
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Slobod
authors.forename: E
authors.initials: E
authors.lastname: Benaim
authors.forename: L
authors.initials: L
authors.lastname: Woodruff
authors.forename: S
authors.initials: S
authors.lastname: Nooner
authors.forename: J
authors.initials: J
authors.lastname: Houston
authors.forename: M
authors.initials: M
authors.lastname: Holladay
authors.forename: T
authors.initials: T
authors.lastname: Lockey
authors.forename: J L
authors.initials: JL
authors.lastname: Hurwitz
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D002469:Cell Separation; D020031:Epstein-Barr Virus Infections / Q000209:etiology / Q000276:immunology / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D016219:Immunotherapy, Adoptive / Q000379:methods; D066298:In Vitro Techniques; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014777:Virus Diseases / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*