Case report: primary human herpesvirus-6 associated with an afebrile seizure in a 3-week-old infant.
We describe a 3-week-old male infant with an afebrile seizure in whom serologic and polymerase chain reaction (PCR) findings support concomitant primary human herpesvirus 6 (HHV-6) infection. Although HHV-6 infection has been associated with first-time febrile seizures and encephalitis in both immunocompetent and immunocompromised hosts, it has not been associated previously with afebrile seizures in healthy infants. This report provides additional evidence of the neuropathogenic potential of HHV-6.
Zerr
Danielle M
DM
Department of Pediatrics, University of Washington, Seattle, Washington, USA. zerr@u.washington.edu
Yeung
Laurence C
LC
Obrigewitch
Rose Mary
RM
Huang
Meei-Li
ML
Frenkel
Lisa M
LM
Corey
Lawrence
L
D005260:Female; D005500:Follow-Up Studies; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D019349:Roseolovirus Infections / Q000097:blood / Q000150:complications / Q000821:virology*; D012640:Seizures / Q000097:blood / Q000150:complications / Q000821:virology*