Common variable immunodeficiency and eosinophilic fasciitis.
The association of eosinophilic fasciitis and immunological defects is rare, especially hypogammaglobulinemia. We report a case of eosinophilic fasciitis occurring in a female, 53 years old, with common variable immunodeficiency. The diagnosis of common variable immunodeficiency was established by chance observation of persistently low levels of all immunoglobulin classes unrelated to protein loss or immunosuppressive treatment, one year after the appearance of eosinophilic fasciitis, which is usually characterized by hypergammaglobulinemia. Our description may prompt the investigation of an increased rate of simultaneous occurrence of eosinophilic fasciitis and common variable immunodeficiency.
Di Gioacchino
Mario
M
Section of Allergy, Immunopathology and Occupational Medicine, Department of Medicine and Sciences of Aging, Via dei Vestini, 13, 66013 Chieti Scalo, Italy.
Masci
Silvio
S
Paolini
Franco
F
Verna
Nicola
N
Angelucci
Domenico
D
Cavallucci
Enrico
E
Paganelli
Roberto
R
D000361:Agammaglobulinemia / Q000150:complications*; D000843:Ankle Joint; D001132:Arm; D001706:Biopsy; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis; D004802:Eosinophilia / Q000150:complications* / Q000175:diagnosis; D005208:Fasciitis / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007866:Leg; D008875:Middle Aged
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M