title: Interpretation of mucoadhesive properties of polymer gel preparations using a tensile strength method.
abstract: We have developed a new tensile strength method for assessing mucoadhesive properties of polymer gels utilising freshly excised porcine nasal mucosa and a texture analyser. In conjunction with this, we propose a method for interpreting the mucoadhesive properties that is based on reasoning about the locus of the failure of a mucoadhesive joint. This involves measuring the cohesiveness of the gel and the mucus layer, respectively, and comparing these results with those obtained from a mucoadhesion measurement. Linear polymers (sodium carboxymethylcellulose, poly(acrylic acid) and sodium hyaluronate) and a cross-linked polymer (poly(acrylic acid)) were used as model polymers in this study. It was shown that the withdrawal speed of the probe should be low, about 0.1 mm s(-1), and that a contact time of 2 min was sufficient. In the mucoadhesion measurements there was no dependence of the results on the contact time in the interval 2-20 min. The tensile work appeared to be more applicable than the fracture strength for interpreting mucoadhesive properties. Furthermore, it was concluded that the interpretation procedure offers a good basis by which to assess whether the measured tensile work reflects a cohesive failure of the gel or a true interaction of the gel with the mucus layer.
authors.affiliation: Department of Pharmacy, Uppsala University, Uppsala Biomedical Centre, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Hägerström
authors.forename: K
authors.initials: K
authors.lastname: Edsman
mesh_terms: D000268:Adhesiveness; D004304:Dosage Forms; D005782:Gels; D009092:Mucous Membrane / Q000378:metabolism*; D011108:Polymers; D013718:Tensile Strength
chemical_list: D004304:Dosage Forms; D005782:Gels; D011108:Polymers