title: Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones.
abstract: A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.
authors.affiliation: Ewha Womans University, School of Pharmacy, Seoul 120-750, South Korea.
authors.forename: Hea-Young Park
authors.initials: HY
authors.lastname: Choo
authors.forename: Mihyun
authors.initials: M
authors.lastname: Kim
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Sang Woong
authors.initials: SW
authors.lastname: Kim
authors.forename: In Kwon
authors.initials: IK
authors.lastname: Chung
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D011809:Quinones