title: MRI detection of cervical metastasis from differentiated thyroid carcinoma.
abstract: BACKGROUND
  With the advent of the use of serum thyroglobulin as a marker for the recurrence of well-differentiated thyroid cancer (WDTC) after total thyroidectomy, clinicians are increasingly faced with the diagnostic dilemma of detecting the site of recurrence in thyroglobulin-positive patients with normal clinical examinations. The high protein content of this thyroglobulin may make it specifically detectable by magnetic resonance (MR) imaging.
  
  
  OBJECTIVE
  To determine the ability of MR imaging to detect the presence of metastatic WDTC in cervical lymph nodes.
  
  
  METHODS
  Retrospective cohort.
  
  
  METHODS
  Blinded review by two independent head and neck radiologists of 34 head and neck MR scans obtained from 26 patients with thyroid cancer (12 with primary disease and 14 with recurrent disease) all of whom subsequently underwent surgical removal of the lymph nodes considered at risk by imaging.
  
  
  RESULTS
  The average overall percent sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MR imaging were 95%, 51%, 84%, 78%, and 83%, respectively. The concordance between the two radiologists was 69%. There was no overall difference in the ability of the MR scan to detect the presence of disease in the upper jugular, lower jugular, or paratracheal nodal stations. However, it was more useful for papillary carcinoma (PPV 86%, accuracy 85%) than for follicular carcinoma or the follicular variant of papillary carcinoma (PPV 63%, accuracy 67%).
  
  
  CONCLUSIONS
  MR imaging is a sensitive and accurate technique for the detection of WDTC, particularly papillary carcinoma, metastatic to cervical lymph nodes. However, the lower specificity of this modality precludes its use as a screening tool.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University, Portland, Oregon 97201, USA.
authors.forename: N D
authors.initials: ND
authors.lastname: Gross
authors.forename: J L
authors.initials: JL
authors.lastname: Weissman
authors.forename: J M
authors.initials: JM
authors.lastname: Talbot
authors.forename: P E
authors.initials: PE
authors.lastname: Andersen
authors.forename: M K
authors.initials: MK
authors.lastname: Wax
authors.forename: J I
authors.initials: JI
authors.lastname: Cohen
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis* / Q000556:secondary*; D000328:Adult; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000556:secondary*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008297:Male; D009333:Neck; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000473:pathology*