title: Inflamed juvenile conjunctival naevus: clinicopathological characterisation.
abstract: OBJECTIVE
  Inflamed juvenile conjunctival naevi (IJCN) are often erroneously suspected to be malignant because of rapid growth. Their clinical and histopathological features have not been characterised in series of patients. The aim of the study is to characterise IJCN clinically and histopathologically.
  
  
  METHODS
  This is a retrospective non-randomised clinicopathological study. All patients younger than 20 years with conjunctival naevi which were excised between 1990 and 2000 were included. The clinical signs of the affected patients and the histopathological findings of the excised lesions were characterised.
  
  
  RESULTS
  A total of 63 conjunctival naevi were resected. 25% of the patients had simple compound conjunctival naevi and 75% had compound naevi with prominent inflammatory histological features (discrete lymphocyte aggregates, plasma cells, and eosinophils). Epithelial cysts and solid epithelial islands were common in the IJCN. The IJCN were all located at or near the limbus, and characterised by recurrent periods of congestion and growth. 75% of the IJCN patients with complete medical records had a history of allergic disease. Marked conjunctival papillary reaction was present in all of the patients, indicating a possible conjunctival allergy.
  
  
  CONCLUSIONS
  IJCN is a unique entity, different from simple compound conjunctival naevus. Its association with allergic conjunctivitis is suggestive, and despite periods of alarmingly rapid growth, is histologically benign.
authors.forename: Ehud
authors.initials: E
authors.lastname: Zamir
authors.forename: Hadas
authors.initials: H
authors.lastname: Mechoulam
authors.forename: Alessandra
authors.initials: A
authors.lastname: Micera
authors.forename: Francesca
authors.initials: F
authors.lastname: Levi-Schaffer
authors.forename: Jacob
authors.initials: J
authors.lastname: Pe'er
mesh_terms: D000293:Adolescent; D002648:Child; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000601:surgery; D003231:Conjunctivitis / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009506:Nevus / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies