Fast drops: a high-throughput approach for setting up protein crystal screens.
There is significant demand to rapidly obtain protein structure information for both structural genomics and drug discovery applications. To meet this demand, all steps in the process of determining protein structure by X-ray crystallography need to be optimized and streamlined with high-throughput methodologies. This communication describes a method that brings high-throughput technology to protein crystallization in both manual and automated modes, suitable for virtually every crystallography laboratory.
Villaseñor
Armando
A
Roche Bioscience, Palo Alto, CA 94304-1397, USA.
Sha
Ma
M
Thana
Peter
P
Browner
Michelle
M
D003460:Crystallization; D004058:Diffusion; D011506:Proteins / Q000737:chemistry* / Q000302:isolation & purification
D011506:Proteins