title: Antimicrobial susceptibility test: from bacterial population analysis to therapy.
abstract: The statistical methods and parameters commonly used to define bacterial susceptibility to antibiotics in vitro such as MIC(50), linear regression or others, usually lead to a considerable loss of information: they do not take into account the heterogeneity of the bacterial population. In contrast, multivariate data analyses are more adapted to the description of biological systems. In this way, a population of a given bacterial species can be separated into homogenous classes corresponding to the different sensitivity and resistance phenotypes. The applications of this mathematical approach include: (i) a new model for more relevant interpretation of antimicrobial susceptibility test results; (ii) numerical estimation of breakpoints having a known risk; (iii) calibration of a technique relative to a reference technique; (iv) detection of strains with new phenotypes; (v) in vitro evaluation of the activity of new compounds.
authors.affiliation: Unité de Recherche UPRES 1622, Hôpital Avicenne-Université Paris-Nord, 125 route de Stalingrad, 93009, Cedex, Bobigny, France.
authors.forename: Maurice R
authors.initials: MR
authors.lastname: Scavizzi
authors.forename: Roger
authors.initials: R
authors.lastname: Labia
authors.forename: Olivier J
authors.initials: OJ
authors.lastname: Petitjean
authors.forename: Alexis
authors.initials: A
authors.lastname: Elbhar
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001331:Automation; D001419:Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy; D002138:Calibration; D024881:Drug Resistance, Bacterial; D018740:Genetic Heterogeneity / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests / Q000379:methods*; D008962:Models, Theoretical; D010641:Phenotype; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents