Effects of chronic administration of sarpogrelate on systolic blood pressure of spontaneously hypertensive rats: comparison with quinapril.
Effects of long-term sarpogrelate (5-HT(2) antagonist) administration on the systolic blood pressure of Wistar-Kyoto normotensive rats (WKYs) and spontaneously hypertensive rats (SHRs) were studied and compared with those of quinapril (ACE-I). Sarpogrelate and quinapril were administered orally for 12 weeks and body and heart weights, systolic blood pressure and the relationships between heart weight and systolic blood pressure were determined. Although both drug treatments caused decreases in the body weight of WKYs and SHRs, only quinapril induced a decrease in the heart weight of SHRs. In addition, quinapril induced a dose-dependent decrease in systolic blood pressure in WKYs and SHRs while sarpogrelate had no effect on systolic blood pressure. Thus, quinapril showed hemodynamic effects on WKYs and SHRs, but the 5-HT(2) antagonists sarpogrelate did not shown such effects, suggesting that 5-HT(2) receptor antagonists may not be important for controlling systolic blood pressure.
Setoguchi
Yuki
Y
Department of Pharmacology, Niigata College of Pharmacy, 5-13-2 Kamishinei-cho, Niigata 950-2081, Japan.
Ohnuki
Toshio
T
Rashid
Mamunur
M
Nakamura
Takashi
T
Hattori
Kaoru
K
Nagatomo
Takafumi
T
Watanabe
Kenichi
K
Mitomi
Akio
A
Nakazawa
Mikio
M
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007546:Isoquinolines / Q000494:pharmacology* / Q000627:therapeutic use; D000077583:Quinapril; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D013386:Succinates / Q000494:pharmacology* / Q000627:therapeutic use; D044005:Tetrahydroisoquinolines; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D007546:Isoquinolines; D012702:Serotonin Antagonists; D013386:Succinates; D044005:Tetrahydroisoquinolines; C064294:sarpogrelate; D000077583:Quinapril