title: Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata.
abstract: The cyclohexenyl chalcone derivative [(-)-hydroxypanduratin A], together with the previously known panduratin A, sakuranetin, pinostrobin, pinocembrin, and dihydro-5,6-dehydrokawain were isolated from the chloroform extract of the red rhizome variety of Boesenbergia pandurata (Robx.) Schltr. [currently known as Boesenbergia rotunda (L.) Mansf., Kulturpfl.]. Their structures were assigned on the basis of their spectroscopic data. (-)-Hydroxypanduratin A and (-)-panduratin A showed significant topical anti-inflammatory activity in the assay of TPA-induced ear edema in rats.
authors.affiliation: Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. scptc@mahidol.ac.th
authors.forename: Patoomratana
authors.initials: P
authors.lastname: Tuchinda
authors.forename: Vichai
authors.initials: V
authors.lastname: Reutrakul
authors.forename: Per
authors.initials: P
authors.lastname: Claeson
authors.forename: Ubonwan
authors.initials: U
authors.lastname: Pongprayoon
authors.forename: Tuanta
authors.initials: T
authors.lastname: Sematong
authors.forename: Thawatchai
authors.initials: T
authors.lastname: Santisuk
authors.forename: Walter C
authors.initials: WC
authors.lastname: Taylor
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002599:Chalcone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D003510:Cyclohexanes / Q000737:chemistry / Q000627:therapeutic use*; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: C450300:(2,4,6-trihydroxyphenyl)(3'-mathyl-2'-(3''-methylbut-2''-enyl)-6-phenylcyclohex-3'-enyl)methanone; D000893:Anti-Inflammatory Agents; D003510:Cyclohexanes; D002599:Chalcone; D013755:Tetradecanoylphorbol Acetate