[Clinical and experimental study on yun'an granule in treating threatened abortion].
OBJECTIVE
To observe the effect of Yun'an Granule (YAG) on threatened abortion.


METHODS
Five hundred and eighty patients were divided randomly into the treatment group and the control group. The effect of YAG in treating 580 patients was observed by double-blinded method and compared with that treated with progesterone (50 cases) or Shoutai Pill (50 cases) in the control group. And experimental study was conducted also.


RESULTS
Clinical results showed that the therapeutic effective rate in YAG (96.9%) was obviously higher than that in the control group (56.0% for progesterone and 86.0% for Shoutai pill), the difference between them was significant (P < 0.05). Experimental results also showed that the YAG had fetus protective effect on the acupuncture or oxytocin induced threatened abortion model in rats, which was better than that of progesterone (P < 0.05). The mean weight of baby rats and placenta delivered by the mother rats which taken YAG were heavier than those which were untreated or treated by progesterone (P < 0.05). In addition, YAG could inhibit the normal or oxytocin stimulated contraction of rat's isolated uterus.


CONCLUSIONS
YAG has good effect in treating threatened abortion and without any adverse effect on fetus.
Zhang
J
J
Shanxi Provincial Academy of Traditional Chinese Medicine, Taiyuan (030012).
Zhang
Y
Y
Liu
G
G
D000033:Abortion, Threatened / Q000188:drug therapy*; D000328:Adult; D000818:Animals; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011374:Progesterone / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D011374:Progesterone