Frequency-dependent response of SI RA-class neurons to vibrotactile stimulation of the receptive field.
Three types of experiment were carried out on anesthetized monkeys and cats. In the first, spike discharge activity of rapidly adapting (RA) SI neurons was recorded extracellularly during the application of different frequencies of vibrotactile stimulation to the receptive field (RF). The second used the same stimulus conditions to study the response of RA-I (RA) cutaneous mechanoreceptive afferents. The third used optical intrinsic signal (OIS) imaging and extracellular neurophysiological recording methods together, in the same sessions, to evaluate the relationship between the SI optical and RA neuron spike train responses to low- vs high-frequency stimulation of the same skin site. RA afferent entrainment was high at all frequencies of stimulation. In contrast, SI RA neuron entrainment was much lower on average, and was strongly frequency-dependent, declining in near-linear fashion from 6 to 200 Hz. Even at 200 Hz, however, unambiguous frequency-following responses were present in the spike train activity of som
Whitsel
B L
BL
Department of Cell and Molecular Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USA. bwhitsel@med.unc.edu
Kelly
E F
EF
Xu
M
M
Tommerdahl
M
M
Quibrera
M
M
D000818:Animals; D002415:Cats; D005110:Extracellular Space / Q000502:physiology; D008251:Macaca; D008465:Mechanoreceptors / Q000502:physiology; D008475:Median Nerve / Q000502:physiology; D008839:Microelectrodes; D009475:Neurons, Afferent / Q000502:physiology; D010812:Physical Stimulation; D017966:Pyramidal Cells / Q000502:physiology*; D012453:Saimiri; D012867:Skin / Q000294:innervation; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*; D013979:Tibial Nerve / Q000502:physiology; D014110:Touch / Q000502:physiology*; D014732:Vibration