[Beneficial effect of AN69 membranes on anemia in hemodialyzed patients].
Biocompatible hemodialysis membranes induce a smaller inflammatory response in hemodialysis patients, and remove a larger amount of higher molecular weight retention products, then cellulose membranes. These phenomena could improve uremic anemia in hemodialysis patients. The objective was to evaluate the effects of biocompatible AN69 membranes on anemia in hemodialysis patients. Twenty-five stable patients undergoing hemodialysis with cuprophane membrane for more than 6 months were studied prospectively. These patients were stratified in 2 groups. Group I (GI): 14 patients switched over to a more biocompatible dialyzer (from cuprophan to AN69) and Group II (GII): 11 patients continued treatment with the same cuprophan membrane. The study lasted 5 months. Baseline hematocrit (%), ferritin (ng/mL), transferrin saturation (%), KTV, PCR (g/kg/day) and dose of erythropoietin (EPO) (UI/week) were measured and were revised monthly. Target hematocrit was 33%-35%. A significant increase of hematocrit became obvious after 2 months in GI without changes in dose of EPO and intensity of dialysis, meanwhile GII remains stable.


CONCLUSIONS
Hemodialysis using AN69 membranes increases hematocrit without modifying intensity of dialysis.
García Cortés
M J
MJ
Servicio de Nefrología, Hospital General de Especialidades Ciudad de Jaén.
Sánchez Perales
M C
MC
Liébana
A
A
Gil
J M
JM
Borrego
F J
FJ
Borrego
J
J
Pérez del Barrio
P
P
Serrano
P
P
Pérez Bañasco
V
V
D000180:Acrylic Resins; D000181:Acrylonitrile / Q000031:analogs & derivatives*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D001672:Biocompatible Materials; D002482:Cellulose / Q000031:analogs & derivatives*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000627:therapeutic use; D005260:Female; D005293:Ferritins / Q000032:analysis; D006400:Hematocrit; D006801:Humans; D007501:Iron / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000295:instrumentation*; D016896:Treatment Outcome
D000180:Acrylic Resins; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D004921:Erythropoietin; C016892:AN-69; D002482:Cellulose; D005293:Ferritins; C009865:cuprammonium cellulose; D007501:Iron; D000181:Acrylonitrile