title: Roles of heat-shock proteins in antigen presentation and cross-presentation.
abstract: Heat-shock proteins chaperone antigenic peptides that are generated within cells. Such chaperoning is a part of the endogenous pathway of antigen presentation by MHC class I molecules. In addition, peptides that are chaperoned by heat-shock proteins, or are released by cell stress or death, are taken up by antigen-presenting cells and re-presented by their MHC molecules.
authors.affiliation: Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-1601, USA.
authors.forename: Zihai
authors.initials: Z
authors.lastname: Li
authors.forename: Antoine
authors.initials: A
authors.lastname: Menoret
authors.forename: Pramod
authors.initials: P
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology; D018832:Molecular Chaperones / Q000276:immunology
chemical_list: D006360:Heat-Shock Proteins; D018832:Molecular Chaperones