An overview of the immune system with specific reference to membrane encapsulation and islet transplantation.
The concept of immunoisolation by use of a bioartificial membrane is discussed, concentrating on the immunological mechanisms that are likely to be operative in the light of recent information on the workings of the immune system. Special attention is given to the use of encapsulation for the purpose of treating autoimmune diabetes by implantation of xenogeneic islet tissue. It is argued that the term immunoisolation is misleading because the immune system is always activated by the indirect pathway of antigen presentation and that the term immunomodulation would be more appropriate.
Gray
D W
DW
Nuffield Department of Surgery, University of Oxford, United Kingdom. derek.gray@nds.ox.ac.uk
D000818:Animals; D021522:Bioartificial Organs; D007107:Immune System / Q000502:physiology*; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D008567:Membranes, Artificial; D014183:Transplantation, Heterologous / Q000276:immunology
D008567:Membranes, Artificial