A new mesangial triumvirate: sulfonylureas, their receptors and endosulfines.
Although sulfonylureas have long been therapeutically utilized for their hypoglycemic properties in type 2 diabetic patients, there is a paucity of clinical or experimental data that suggests that this pharmacotherapeutic class confers a benefit on the course of diabetic renal disease. Because the mesangial compartment is central to the fibrogenic response that evolves during the course of diabetic nephropathy, determining the metabolic influence of sulfonylureas on mesangial cells is important. In this article, the current knowledge regarding the metabolic and functional consequences of a mesangial triumvirate of sulfonylureas, their sulfonylurea receptors and sulfonylurea-like ligands termed endosulfines will be reviewed.
Yee
Jerry
J
Department of Medicine, Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI 48202-2689, USA. JYee1@Hfhs.org
Szamosfalvi
Balàzs
B
D018528:ATP-Binding Cassette Transporters; D000818:Animals; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000378:metabolism*; D029721:Drosophila Proteins; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism; D005920:Glomerular Mesangium / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D036341:Intercellular Signaling Peptides and Proteins; D009004:Monosaccharide Transport Proteins / Q000187:drug effects; D010455:Peptides / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug / Q000378:metabolism*; D013453:Sulfonylurea Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D064233:Sulfonylurea Receptors
D018528:ATP-Binding Cassette Transporters; D029721:Drosophila Proteins; D007004:Hypoglycemic Agents; D036341:Intercellular Signaling Peptides and Proteins; D009004:Monosaccharide Transport Proteins; D010455:Peptides; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug; D013453:Sulfonylurea Compounds; D064233:Sulfonylurea Receptors; C483180:endos protein, Drosophila; C075663:endosulfine