Neuromuscular transmission in migraine patients with prolonged aura.
P/Q Ca2+ channels are genetically abnormal in most cases of familial hemiplegic migraine (FHM) and may be involved in other types of migraine. They are also found at the neuromuscular junctions, where they control stimulation-induced acetylcholine release. Prolonged aura is a very frequent clinical feature in FHM patients. The objective of this study was thus to explore neuromuscular transmission in migraine with typical and prolonged aura patients. We performed single fiber electromyography (SFEMG) in such patients and compared them to a group of healthy volunteers. Results were expressed as mean jitter (MCD) and percentage of single endplate abnormalities. Mean MCD was on average comparable in controls and migraineurs. By contrast, single endplate abnormalities were only found in patients (p < 0.01), especially in those with prolonged aura (p < 0.001). These results suggest subtle impairment of neuromuscular transmission in a subgroup of migraineurs characterized by prolonged aura, which might be due to dysfunctioning P/Q Ca(2+)-channels.
Ambrosini
A
A
Headache Clinic IRCCS INM Neuromed, Pozzilli, Isernia, Italy.
de Noordhout
A M
AM
Schoenen
J
J
D000200:Action Potentials / Q000235:genetics; D000328:Adult; D020865:Calcium Channels, P-Type / Q000235:genetics / Q000378:metabolism*; D020907:Calcium Channels, Q-Type / Q000235:genetics / Q000378:metabolism*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000150:complications* / Q000235:genetics / Q000503:physiopathology*; D009431:Neural Conduction / Q000235:genetics; D009469:Neuromuscular Junction / Q000378:metabolism / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000503:physiopathology; D011930:Reaction Time / Q000235:genetics; D009435:Synaptic Transmission / Q000235:genetics
D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type