title: Crystallization and preliminary X-ray analysis of the antimalarial and cytotoxic alkaloid cryptolepine complexed with the DNA fragment d(CCTAGG)2.
abstract: Crystals of the indoloquinoline alkaloid cryptolepine complexed with the DNA fragment d(CCTAGG)(2) have been grown by the hanging-drop technique at 293 K using ammonium sulfate as the precipitating agent. Over a period of three weeks, yellow tapering bullet-shaped crystals grew to maximum dimensions of 0.2 x 0.1 x 0.1 mm. The crystals belong to space group P6(4), with unit-cell parameters a = b = 29.960, c = 39.64 A, alpha = beta = 90, gamma = 120 degrees, and diffract to 1.4 A.
authors.affiliation: Institut de Biologia Molecular de Barcelona, CSIC, Jordi Girona 18, E-08034 Barcelona, Spain.
authors.forename: J N
authors.initials: JN
authors.lastname: Lisgarten
authors.forename: J
authors.initials: J
authors.lastname: Pous
authors.forename: M
authors.initials: M
authors.lastname: Coll
authors.forename: C W
authors.initials: CW
authors.lastname: Wright
authors.forename: J
authors.initials: J
authors.lastname: Aymami
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000378:metabolism*; D000962:Antimalarials / Q000737:chemistry* / Q000378:metabolism; D003460:Crystallization; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D026121:Indole Alkaloids; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011804:Quinolines / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D026121:Indole Alkaloids; D007211:Indoles; D011804:Quinolines; C024015:cryptolepine; D004247:DNA