New lanostanoids from the mushroom Ganoderma lucidum.
From a lipophilic extract of the fruiting body of Ganoderma lucidum, three new lanostanoids, 8beta,9alpha-dihydroganoderic acid J (1), methyl 8beta,9alpha-dihydroganoderate J (2), and 20-hydroxylganoderic acid G (3), along with 12 known lanostanoids and two ergostane sterols were isolated. The structures of 1-3 were determined by interpretation of their spectroscopic data.
Ma
Jiyuan
J
Pharmanex, Inc., 75 West Center Street, Provo, Utah 84601, USA.
Ye
Qing
Q
Hua
Yanjun
Y
Zhang
Decheng
D
Cooper
Raymond
R
Chang
Michael N
MN
Chang
Joseph Y
JY
Sun
Hao H
HH
D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020128:Inhibitory Concentration 50; D007371:Interferon-gamma / Q000032:analysis / Q000097:blood; D007376:Interleukin-2 / Q000032:analysis / Q000097:blood; D015847:Interleukin-4 / Q000032:analysis / Q000097:blood; D007810:Lanosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D020940:Reishi / Q000737:chemistry* / Q000276:immunology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C449846:20-hydroxylganoderic acid G; C449847:8,9-dihydroganoderate J; C449845:8,9-dihydroganoderic acid J; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D007810:Lanosterol; D015847:Interleukin-4; D007371:Interferon-gamma