title: A closer look at proteolysis and MHC-class-II-restricted antigen presentation.
abstract: Antigen presentation by MHC class II molecules relies on the action of endocytic proteases, which are differentially expressed in antigen-presenting cells and are regulated by different components of the immune system. Endocytic enzymes process and convert exogenous antigens into peptidic determinants capable of interaction with MHC class II molecules. Chemical and genetic tools have recently been developed to study the role of lysosomal proteases in antigen presentation.
authors.affiliation: Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Lennon-Duménil
authors.forename: Arnold H
authors.initials: AH
authors.lastname: Bakker
authors.forename: Paula
authors.initials: P
authors.lastname: Wolf-Bryant
authors.forename: Hidde L
authors.initials: HL
authors.lastname: Ploegh
authors.forename: Cécile
authors.initials: C
authors.lastname: Lagaudrière-Gesbert
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D004705:Endocytosis / Q000276:immunology; D010450:Endopeptidases / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D051379:Mice; D010588:Phagosomes / Q000276:immunology; D020543:Proteome
chemical_list: D000949:Histocompatibility Antigens Class II; D020543:Proteome; D010450:Endopeptidases