Anchorage-dependent ERK signaling--mechanisms and consequences.
Integrin-mediated adhesion to the extracellular matrix regulates the cellular response to mitogens. Anchorage-dependent growth factor activation of the extracellular signal-regulated kinase (ERK) is an intensely studied example of this regulation. Given the central role of ERK in mediating cell migration, division, and survival, it is also an extremely important example. Recent work has demonstrated that cell adhesion can regulate ERK signaling at several checkpoints and has begun to define the mechanism and consequences associated with anchorage-dependent effects on the ERK cascade.
Howe
Alan K
AK
University of North Carolina, Chapel Hill, School of Medicine, Department of Pharmacology, Campus Box 7365, Chapel Hill, North Carolina 27599-3765, USA. Alan_Howe@med.unc.edu
Aplin
Andrew E
AE
Juliano
R L
RL
D000818:Animals; D023102:Anoikis; D002448:Cell Adhesion / Q000502:physiology*; D002453:Cell Cycle; D002455:Cell Division; D002465:Cell Movement; D002470:Cell Survival; D004815:Epidermal Growth Factor / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D016023:Integrins / Q000378:metabolism; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*
D016023:Integrins; D004815:Epidermal Growth Factor; D020928:Mitogen-Activated Protein Kinases