title: [Changes of serum elastase, alpha 1-antitrypsin, procollagen III peptide and malonaldehyde in smokers with and without chronic obstructive pulmonary diseases].
abstract: OBJECTIVE
  Serum elastase, alpha(1)-antitrypsin (alpha(1)-AT), procollagen III peptide (PIIIP) and malonaldehyde (MDA) were studied in smokers with and without chronic obstructive pulmonary disease (COPD) to explore the roles of these factors in COPD induced by smoking.
  
  
  METHODS
  A design of 154-pair case-control study was used. alpha(1)-AT, MDA and PIIIP were determined with colorimetric method, fluo-spectrophotometric method and radio-immunological assay, respectively, in non-smoker control and smokers with and without COPD.
  
  
  RESULTS
  Serum PIIIP content was increased in smokers and alpha(1)-AT decreased significantly in patients with COPD.
  
  
  CONCLUSIONS
  Decreased alpha(1)-AT may be a susceptible factor in the development of COPD caused by smoking.
authors.affiliation: Institute of Basic Medical Science, Chinese Academy of Medical Sciences, Beijing 100005.
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Cheng
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Hua
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: Q
authors.initials: Q
authors.lastname: Zhao
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: F
authors.initials: F
authors.lastname: Qin
authors.forename: L
authors.initials: L
authors.lastname: Yu
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000209:etiology; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000032:analysis*
chemical_list: D010446:Peptide Fragments; D011347:Procollagen; D000515:alpha 1-Antitrypsin; C041876:procollagen Type III-N-terminal peptide; D008315:Malondialdehyde; D010196:Pancreatic Elastase