A case of rapid progressive glomerulonephritis with IgA deposits after renal transplantation.
A 46-yr-old Japanese male who underwent a second cadaveric kidney transplantation on 31 October 1996 after suffering Type II diabetic mellitus for 25 yr was admitted to our institute on 23 January 1999, because of colicky abdominal pain and abdominal discomfort. Elevated levels of serum creatinine, severe proteinuria and microscopic haematuria were observed. The allograft biopsy specimen disclosed crescentic glomerulonephritis. Immunofluorescence showed granular deposits of mainly IgA and C3 along glomerular capillary walls and mesangial areas. Electron microscopy showed extensive subepithelial and mesangial electron dense deposits. Rapid and irreversible worsening of graft function led to resumption of haemodialysis on 31 May 1999. We speculated that this case was an atypical form of de novo Henoch-Schönlein purpura nephritis (HSPN) in transplanted kidney because of the histopathological findings of the allograft biopsy and clinical symptoms.
Shimizu
T
T
Department of Urology, Kidney Center, Tokyo Women's Medical University, Japan.
Tanabe
K
K
Tokumoto
T
T
Shimmura
H
H
Koga
S
S
Ishikawa
N
N
Oshima
T
T
Toma
H
H
Yamaguchi
Y
Y
D002102:Cadaver; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000473:pathology*; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology / Q000473:pathology; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged