title: Non-invasive proportional assist and pressure support ventilation in patients with cystic fibrosis and chronic respiratory failure.
abstract: BACKGROUND
  Patients with advanced cystic fibrosis can benefit from non-invasive positive pressure ventilation (NPPV) for the treatment of acute decompensation as well as for the management of chronic respiratory failure. This study was undertaken to compare the physiological effects of non-invasive proportional assist ventilation (PAV) and pressure support ventilation (PSV) on ventilatory pattern, transcutaneous blood gas tensions, and diaphragmatic effort in stable patients with cystic fibrosis and chronic CO2 retention.
  
  
  METHODS
  In 12 patients two periods of spontaneous breathing were followed randomly by PSV (12 (3) cm H2O) and PAV (flow assist 4.9 (1.3) cm H2O/l.s, volume assist 18.9 (5.1) cm H2O/l) set for the patient's comfort and administered for 40 minutes with 2 cm H2O continuous positive airway pressure. Ventilatory pattern, transcutaneous blood gas tensions, and surface diaphragmatic electromyography were measured in the last 10 minutes of each application.
  
  
  RESULTS
  On average, both PSV and PAV improved ventilation (+30%), tidal volume (+30%), and transcutaneous CO2 (-7%) while reducing diaphragmatic activity (-30% with PSV, -20% with PAV). Mean inspiratory airway pressure was lower during PAV than during PSV (9.7 (1.9) and 12.9 (2.7) cm H2O, respectively; p<0.05). The mean coefficient of variation of tidal volume was about 20% (range 11-39%) during spontaneous breathing and did not change with either PAV or PSV.
  
  
  CONCLUSIONS
  These results show that short term administration of nasal PAV and PSV to patients with stable cystic fibrosis with chronic respiratory insufficiency is well tolerated, improves ventilation and blood gas tensions, and unloads the diaphragm.
authors.affiliation: Centro Regionale Fibrosi Cistica, Azienda Ospedaliera di Verona, Ospedale Civile Maggiore di Borgo Trento, Verona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Serra
authors.forename: G
authors.initials: G
authors.lastname: Polese
authors.forename: C
authors.initials: C
authors.lastname: Braggion
authors.forename: A
authors.initials: A
authors.lastname: Rossi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002245:Carbon Dioxide / Q000097:blood; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D003964:Diaphragm / Q000502:physiology; D004576:Electromyography; D005246:Feedback / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011175:Positive-Pressure Respiration / Q000379:methods*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*; D013990:Tidal Volume / Q000502:physiology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen