Regional differences in feeding and other behaviors elicited by N-methyl-D-aspartic acid in the rodent hypothalamus: a reverse microdialysis mapping study.
Regional differences in the feeding stimulatory actions of hypothalamically delivered N-methyl-D-aspartate (NMDA) were investigated. NMDA (660 microM intraprobe) delivered by reverse microdialysis into the tuberal lateral hypothalamus (tLH) reliably elicited feeding in satiated rats. The average food intake was 8.6 g in 50 min, and during the infusion rats spent 26% of the time eating, compared to less than 1% before NMDA treatment. In contrast, NMDA did not affect feeding when reverse dialyzed into the anterior LH (aLH), posterior LH (pLH) or the medial hypothalamus (MH). NMDA had no apparent behavioral effect in the aLH; in contrast, it significantly decreased the time spent resting/sleeping when infused into each of the other three areas tested. Additionally, in the medial hypothalamus, NMDA infusions increased time spent grooming; while in the pLH only alertness was significantly increased. These data underscore the functional and anatomical heterogeneity of the hypothalamus, and implicate glutamate and NMDA receptors in different portions of the hypothalamus in the control of eating, grooming and arousal.
Duva
Mark A
MA
Department of Psychology, University of California, Riverside, Riverside, CA 92521, USA. mduva@citrus.ucr.edu
Tomkins
Edward M
EM
Moranda
L Morgan
LM
Kaplan
Roman
R
Sukhaseum
Anouphab
A
Bernardo
Josel P
JP
Stanley
B Glenn
BG
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001931:Brain Mapping; D005247:Feeding Behavior / Q000187:drug effects*; D006120:Grooming / Q000187:drug effects; D007031:Hypothalamus / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D017551:Microdialysis; D016202:N-Methylaspartate / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014851:Wakefulness / Q000187:drug effects
D016202:N-Methylaspartate