[Variability in drug response caused by the genetic polymorphisms of receptors].
A greater deal of attention has been given to the genetic polymorphism of receptors and related variability in drug response. In recent years, studies on pharmacogenomics accomplished remarkable progress in this issue. These studies include, the relationships between beta 2-adrenegic receptor polymorphism and the pharmacological effect of blonchodilator, dopamine D2 or 5-HT2 receptor polymorphism and response to antipsychotic medication, vitamin D receptor variants and the active vitamin D therapy, PPAR gamma and the insulin resistance treatment and so on. However, some of them are still controversial, and it requires further investigation to apply these studies to the actual therapy.
Tanigawara
Yusuke
Y
Department of Pharmacy, Keio University Hospital.
Iketani
Osamu
O
Yamayoshi
Yasuko
Y
D015894:Genome, Human; D006801:Humans; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics; D011955:Receptors, Drug / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D018343:Receptors, Adrenergic, beta-2; D018160:Receptors, Cytoplasmic and Nuclear; D017448:Receptors, Dopamine D2; D011955:Receptors, Drug; D011985:Receptors, Serotonin; D014157:Transcription Factors