title: Three-Dimensional finite-element analyses for radio-frequency hepatic tumor ablation.
abstract: Radio-frequency (RF) hepatic ablation, offers an alternative method for the treatment of hepatic malignancies. We employed finite-element method (FEM) analysis to determine tissue temperature distribution during RF hepatic ablation. We constructed three-dimensional (3-D) thermal-electrical FEM models consisting of a four-tine RF probe, hepatic tissue, and a large blood vessel (10-mm diameter) located at different locations. We simulated our FEM analyses under temperature-controlled (90 degrees C) 8-min ablation. We also present a preliminary result from a simplified two-dimensional (2-D) FEM model that includes a bifurcated blood vessel. Lesion shapes created by the four-tine RF probe were mushroom-like, and were limited by the blood vessel. When the distance of the blood vessel was 5 mm from the nearest distal electrode 1) in the 3-D model, the maximum tissue temperature (hot spot) appeared next to electrodes A. The location of the hot spot was adjacent to another electrode 2) on the opposite side when the blood vessel was 1 mm from electrode A. The temperature distribution in the 2-D model was highly nonuniform due to the presence of the bifurcated blood vessel. Underdosed areas might be present next to the blood vessel from which the tumor can regenerate.
authors.affiliation: Department of Electronics Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
authors.forename: Supan
authors.initials: S
authors.lastname: Tungjitkusolmun
authors.forename: S Tyler
authors.initials: ST
authors.lastname: Staelin
authors.forename: Dieter
authors.initials: D
authors.lastname: Haemmerich
authors.forename: J Z
authors.initials: JZ
authors.lastname: Tsai
authors.forename: John G
authors.initials: JG
authors.lastname: Webster
authors.forename: Fred T
authors.initials: FT
authors.lastname: Lee
authors.forename: David M
authors.initials: DM
authors.lastname: Mahvi
authors.forename: Vicken R
authors.initials: VR
authors.lastname: Vorperian
mesh_terms: D017115:Catheter Ablation / Q000295:instrumentation*; D004566:Electrodes; D020342:Finite Element Analysis; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D012984:Software; D013696:Temperature