[Expression and clinical study of multidrug resistance gene and multidrug resistance associated protein gene in acute leukemia].
OBJECTIVE
To evaluate the relationship between the expression of multidrug resistance gene (mdr1) or multidrug resistance-associated protein gene (MRP) and the prognosis in patients with acute leukemia (AL).


METHODS
The expression of mdr1 and MRP were measured in 55 patients with AL by reverse transcription polymerase chain reaction (RT-PCR).


RESULTS
The mdr1 and MRP gene expression levels in the relapsed AL and the blastic phase of CML group (0.735 +/- 0.249, 1.157 +/- 0.447) were significantly higher than those in the untreated group (0.408 +/- 0.186, 0.465 +/- 0.253) (P < 0.01). The complete remission (CR) rate in high mdr1 and MRP expression group was significantly lower than that in low mdr1 and MRP expression group (P < 0.01) in a follow up of 40 AL patients.


CONCLUSIONS
Increased expression of mdr1 and MRP gene might be an important factor for predicting drug resistance, relapse and unfavorable prognosis in AL patients.
Ma
J
J
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021.
Lai
Y
Y
Lu
Y
Y
Niu
W
W
D000208:Acute Disease; D000328:Adult; D018432:Drug Resistance, Multiple / Q000235:genetics*; D015870:Gene Expression; D019450:Genes, MDR; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction
D027425:ATP-Binding Cassette, Sub-Family C Proteins