[The clinical significance of changes in plasma levels of alpha-granule membrane protein and D-dimer in patients with unstable angina].
OBJECTIVE
To explore the relationship between platelet activation and enhanced coagulability and the occurrence unstable angina.


METHODS
Plasma levels of a-granule membrane protein (GMP-140) and fibrin D-dimer were measured in 22 patients with unstable angina during the acute phase and after relief. The same procedure were compared with those in 20 control subjects and 18 patients with stable angina.


RESULTS
Plasma levels of GMP-140 and D-dimer were significantly higher in patients with unstable angina both during the acute phase (P < 0.01) and after the relief (P < 0.05) as compared with those in control subjects and patients with stable angina, but there was no significant difference between the latter two groups (P > 0.05). There was also no significant difference between the patients with unstable angina during the acute phase and after the relief (P > 0.05).


CONCLUSIONS
It is shown that activation of platelet and coagulation system combined with endothelial injury may play an important role in the development of unstable angina.
Zhang
J
J
Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003.
Zhang
F
F
Shen
Y
Y
Zhai
Y
Y
Shang
B
B
D000368:Aged; D000789:Angina, Unstable / Q000097:blood*; D001777:Blood Coagulation; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D015539:Platelet Activation
D005338:Fibrin Fibrinogen Degradation Products; D019007:P-Selectin; C036309:fibrin fragment D