[High frequency oscillatory ventilation with perfluorocarbon in rabbits with acute lung injury].
OBJECTIVE
To investigate the efficacy of high frequency oscillation with perfluorocarbon (PFC) in rabbits with acute lung injury (ALI).


METHODS
Twenty four rabbits with ALI induced by repeated saline lung lavage were randomly assigned to four groups: conventional mechanical ventilation (CMV) group, CMV + PFC group, high frequency oscillation (HFO) group and HFO + PFC group. All rabbits were ventilated for two hours. Blood gases, respiratory system dynamic compliance (Cdyn) and intrapulmonary shunt fraction (Qs/Qt) were measured and calculated at 30, 60, and 120 min during experiment.


RESULTS
Compared with the CMV, statistically improvements were shown in gas exchange, Cdyn and Qs/Qt at 30 min in the CMV + PFC group [PaO(2) 122 mm Hg +/- 15 mm Hg vs. 692 mm Hg +/- 82 mm Hg, PaCO(2) 29.1 mm Hg +/- 2.7 mm Hg vs. 47.1 mm Hg +/- 2.9 mm Hg, Cdyn (1.35 +/- 0.13) vs (0.97 +/- 0.13) ml.cm H(2)O(-1).kg(-1), Qs/Qt 18.1 +/- 1.1 vs.24.5 +/- 2.9] (P < 0.01 approximately 0.05) and remained stable for two hours. Compared with HFO, HFO + PFC improved oxygenation and ventilation more rapidly than HFO did. At 30 min intervals gas exchange and Qs/Qt were significantly improved (PaO(2) 174.9 +/- 18.5 vs 132.3 +/- 19.4, PaCO(2) 26.1 +/- 2.6 vs 34.9 +/- 4.6, Qs/Qt 17.1 +/- 2.4 vs 19.8 +/- 0.9) (P < 0.05)and remained stable to 60 min. The same differences were seen at 60 min.


CONCLUSIONS
In rabbits with ALI, CMV + PFC could induce a significant improvement in gas exchange and Cdyn. HFO + PFC leads more rapidmy to reach best gas exchange and Cdyn.
Chen
X
X
Emergency Center of Beijing Children's Hospital, Capital University of Medical Sciences, Beijing 100045, China.
Cui
N
N
Geng
R
R
D000818:Animals; D001784:Blood Gas Analysis; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage*; D006612:High-Frequency Ventilation; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D011659:Pulmonary Gas Exchange; D011817:Rabbits; D012121:Respiration, Artificial
D005466:Fluorocarbons