A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion.
A novel lymphocyte-specific immunoglobulin superfamily protein (19A) has been cloned. The predicted 335-amino-acid sequence of 19A represents a Type 1 membrane protein with homology with the CD2 family of receptors. A molecular model of the two predicted extracellular immunoglobulin-like domains of 19A has been generated using the crystal structure of CD2 as a template. In isolated lymphocytes, expression of 19A is induced by various activation stimuli, and enforced expression of the 19A gene promotes homotypic cell adhesion in a B-cell-line model. Collectively these data imply that the 19A protein plays a role in regulation of lymphocyte adhesion.
Murphy
John J
JJ
Infection and Immunity Research Group, Division of Life Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK. john.murphy@kcl.ac.uk
Hobby
Paul
P
Vilarino-Varela
Juan
J
Bishop
Benjamin
B
Iordanidou
Panagiota
P
Sutton
Brian J
BJ
Norton
John D
JD
D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D001483:Base Sequence; D015152:Blotting, Northern; D018801:CD2 Antigens / Q000737:chemistry*; D002448:Cell Adhesion; D002460:Cell Line; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry*; D008213:Lymphocyte Activation; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D012313:RNA / Q000378:metabolism; D011971:Receptors, Immunologic / Q000096:biosynthesis* / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid; D000071176:Signaling Lymphocytic Activation Molecule Family; D013997:Time Factors; D014018:Tissue Distribution; D014162:Transfection
D018801:CD2 Antigens; D018076:DNA, Complementary; D007136:Immunoglobulins; D011971:Receptors, Immunologic; C448987:SLAMF7 protein, human; D000071176:Signaling Lymphocytic Activation Molecule Family; D012313:RNA