[X-linked thin basement membrane nephropathy was linked with COL4A5 gene].
OBJECTIVE
To genetically analyze 9 thin basement membrane nephropathy (TBMN) pedegrees using microsatellite marker 2B6 and DXS101 closely linked with COL4A5 gene located on chromosome X.


METHODS
Genomic DNA was extracted. Highly polymorphic microsatellite markers (2B6 and DXS101) closely linked with COL4A5 gene located on chromosome X were amplified with PCR. Nine TBMN families were analysed.


RESULTS
Three of 9 TBMN families were linked with COL4A5 gene on chromosome X (lod score = 2.7, theta = 0.00).


CONCLUSIONS
X-linked TBMN is linked with COL4A5 gene on chromosome X.
Zhang
C
C
Department of Nephrology, The First Hospital of Beijing Medical University, Beijing 100034, China.
Zhu
S
S
Zhang
Y
Y
D000328:Adult; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D024141:Collagen Type IV / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009394:Nephritis, Hereditary / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D016133:Polymerase Chain Reaction; D014960:X Chromosome / Q000235:genetics*
D024141:Collagen Type IV; D004247:DNA