title: The Brugada syndrome.
abstract: The Brugada syndrome describes a subgroup of patients at risk for the occurrence of ventricular fibrillation who have no definable structural heart disease associated with a right bundle branch block conduction pattern and ST-segment elevation in the right precordial leads. This syndrome is caused by genetic defects in the alpha subunit of the sodium channel. This defect causes a reduction in the sodium channel current, which accentuates the epicardial action potential notch leading to ST-segment elevation. Sodium channel blockers can potentiate these findings and screen for patients with intermittent baseline electrocardiographic findings. Because of the poor prognosis of such patients, symptomatic patients should be treated with an implantable cardioverter-defibrillator.
authors.affiliation: Division of Cardiology, Cardiovascular Center, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.
authors.forename: Gerald V
authors.initials: GV
authors.lastname: Naccarelli
authors.forename: Charles
authors.initials: C
authors.lastname: Antzelevitch
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Wolbrette
authors.forename: Jerry C
authors.initials: JC
authors.lastname: Luck
mesh_terms: D002037:Bundle-Branch Block / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D003131:Combined Modality Therapy; D017147:Defibrillators, Implantable; D003937:Diagnosis, Differential; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D006329:Heart Conduction System / Q000473:pathology*; D006801:Humans; D011379:Prognosis; D026941:Sodium Channel Blockers / Q000627:therapeutic use; D015222:Sodium Channels / Q000235:genetics; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*
chemical_list: D026941:Sodium Channel Blockers; D015222:Sodium Channels