title: Lower mortality in patients with the DD genotype of the angiotensin-converting enzyme gene after acute myocardial infarction.
abstract: OBJECTIVE
  The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been associated with different serum ACE concentrations and cardiac ACE activity. We assessed whether the ACE gene I/D polymorphism influenced cardiac mortality in Japanese patients with acute myocardial infarction.
  
  
  RESULTS
  The ACE gene I/D polymorphism was determined in 441 consecutive patients with a first myocardial infarction. There were 69 patients (16%) with the DD genotype, 194 patients (44%) with the ID genotype, and 178 patients (40%) with the II genotype. During a mean follow-up of 9.4 months, there were 49 cardiac deaths (DD, n = 4; ID, n = 26; II, n = 19). The DD genotype was significantly associated with a lower mortality than the other genotypes (p = 0.0363) by Cox regression analysis adjusted for age, sex, site of myocardial infarction, Killip functional class, reperfusion therapy during acute phase, ACE inhibitor use, and beta-blocker use.
  
  
  CONCLUSIONS
  In a selected cohort of Japanese patients, the DD genotype was associated with a significantly lower cardiac mortality after a first myocardial infarction.
authors.affiliation: Cardiovascular Center, Kansai Medical University, Moriguchi-City, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tokunaga
authors.forename: H
authors.initials: H
authors.lastname: Tsuji
authors.forename: T
authors.initials: T
authors.lastname: Nishiue
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Miyasaka
authors.forename: D
authors.initials: D
authors.lastname: Saitou
authors.forename: T
authors.initials: T
authors.lastname: Iwasaka
mesh_terms: D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000401:mortality*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D016019:Survival Analysis
chemical_list: D007703:Peptidyl-Dipeptidase A