[Hormone replacement therapy and uterine leiomyomas].
The purpose of the authors is to survey the effect that HRT has on uterine fibromas.



It was made a very prospective one-year study on 25 women with uterine fibromas, 33-55 years old (the majority of them had subserose uterine fibromas with normal sizes). We are used the HRT with Climent and Cyclo-proginova (Schering A.G.). According to the kind of the treatment that was used, two groups were formed: the 1st had treated with Climent (n = 18) and the 2nd--with Cyclo-proginova (n = 7). The changes in the growth of the fibromas were observed with echography at the 1st, 3rd, 6th and 12th months.



The significant changes in the growth are absent in the 1st group, while in the 2nd group in 6 of the 7 cases showed a little increasing in the size of the fibromas (to 25 mm). However, in 2 of all women who had bleeding, were treated with abrasio residuorum, and the histological result is a simple glandular hyperplasia. The missing of important changes in the size of the fibromas can be explained with the progestogens compartment, which decreased of estrogen receptors and with the stimulating effect of the 17 beta-OH-steroiddehydrogenasis, which reduced the estradiol in the cells.



HRT could be used at women having fibromas without significant changes in the growth, under very strict control by echograpry.
Porozhanova
V
V
Bozhinova
S
S
Khristova
V
V
D000328:Adult; D017373:Cyproterone Acetate / Q000627:therapeutic use; D004338:Drug Combinations; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D007889:Leiomyoma / Q000139:chemically induced* / Q000000981:diagnostic imaging; D009644:Norgestrel / Q000627:therapeutic use; D011446:Prospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging
D004338:Drug Combinations; C103294:estradiol valerate, cyproterone acetate drug combination; D009644:Norgestrel; D017373:Cyproterone Acetate; D004958:Estradiol