title: Structure-activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576.
abstract: As part of a programme to identify further analogues of the dual topo I/II inhibitor XR11576, we describe here the syntheses and SAR studies of various 'minimal' and 3,4-benzofused phenazine chromophores of the phenazine template of XR11576.
authors.affiliation: Department of Medicinal Chemistry, Xenova Ltd., 957 Buckingham Avenue, Slough, Berkshire SL1 4NL, UK. shouming_wang@xenova.co.uk
authors.forename: Shouming
authors.initials: S
authors.lastname: Wang
authors.forename: Warren
authors.initials: W
authors.lastname: Miller
authors.forename: John
authors.initials: J
authors.lastname: Milton
authors.forename: Nigel
authors.initials: N
authors.lastname: Vicker
authors.forename: Alistair
authors.initials: A
authors.lastname: Stewart
authors.forename: Peter
authors.initials: P
authors.lastname: Charlton
authors.forename: Prakash
authors.initials: P
authors.lastname: Mistry
authors.forename: David
authors.initials: D
authors.lastname: Hardick
authors.forename: William A
authors.initials: WA
authors.lastname: Denny
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D010619:Phenazines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured
chemical_list: C446952:4-methoxybenzo(a)phenazine-11-carboxylic acid (2-(dimethylamino)-1-methylethyl)amide; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D010619:Phenazines; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors