title: Characterisation of cross-reactivity of virus neutralising antibodies induced by feline panleukopenia virus and canine parvoviruses.
abstract: It was recently reported that canine parvoviruses (CPV) had entered cat populations and induced disease in infected cats, while they had affected only dogs in the past. It is important to determine whether conventional feline panleukopenia virus (FPLV) vaccines protect against recent CPV infections. In this study, the cross-reactivity of virus-neutralising (VN) and haemagglutinin-inhibition (HI) antibodies in cats induced by FPLV and CPV s were examined. Lower cross-reactivities of VN and HI antibodies against each CPV strain were observed in cats experimentally inoculated with FPLV or vaccinated with an inactivated FPLV vaccine. In addition, we revealed the existence of a novel type of FPLV, which reacted weakly with antibodies induced by the conventional FPLV vaccine.
authors.affiliation: Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Tohya
authors.forename: E
authors.initials: E
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Mochizuki
mesh_terms: D000372:Agglutination Tests / Q000662:veterinary; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D002371:Cat Diseases / Q000276:immunology / Q000821:virology; D002415:Cats; D003429:Cross Reactions; D004283:Dog Diseases / Q000276:immunology / Q000821:virology; D004285:Dogs; D005254:Feline Panleukopenia / Q000276:immunology*; D028301:Feline Panleukopenia Virus / Q000276:immunology* / Q000472:pathogenicity; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D009500:Neutralization Tests / Q000662:veterinary; D010322:Parvoviridae Infections / Q000276:immunology / Q000662:veterinary*; D017993:Parvovirus, Canine / Q000276:immunology* / Q000472:pathogenicity; D013047:Specific Pathogen-Free Organisms
chemical_list: D000914:Antibodies, Viral