title: 7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
abstract: The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
authors.affiliation: Celltech R & D, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
authors.forename: George M
authors.initials: GM
authors.lastname: Buckley
authors.forename: Nicola
authors.initials: N
authors.lastname: Cooper
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Davenport
authors.forename: Hazel J
authors.initials: HJ
authors.lastname: Dyke
authors.forename: Fiona P
authors.initials: FP
authors.lastname: Galleway
authors.forename: Lewis
authors.initials: L
authors.lastname: Gowers
authors.forename: Alan F
authors.initials: AF
authors.lastname: Haughan
authors.forename: Hannah J
authors.initials: HJ
authors.lastname: Kendall
authors.forename: Christopher
authors.initials: C
authors.lastname: Lowe
authors.forename: John G
authors.initials: JG
authors.lastname: Montana
authors.forename: Janet
authors.initials: J
authors.lastname: Oxford
authors.forename: Joanna C
authors.initials: JC
authors.lastname: Peake
authors.forename: C Louise
authors.initials: CL
authors.lastname: Picken
authors.forename: Marianna D
authors.initials: MD
authors.lastname: Richard
authors.forename: Verity
authors.initials: V
authors.lastname: Sabin
authors.forename: Andrew
authors.initials: A
authors.lastname: Sharpe
authors.forename: Julie B H
authors.initials: JB
authors.lastname: Warneck
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001665:Binding Sites; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D005663:Furans / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D006168:Guinea Pigs; D007202:Indicators and Reagents; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D020889:Rolipram / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D018927:Anti-Asthmatic Agents; D005663:Furans; D007202:Indicators and Reagents; D010726:Phosphodiesterase Inhibitors; D011725:Pyridines; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram