title: Sensory and affective components of orofacial pain: is it all in your brain?
abstract: In this paper, we shall review several chronic orofacial pain conditions with emphasis on those that are essentially refractory to treatment. We shall present a review of current and past literature that describes the various pain phenomena as well as their underlying central mechanisms. New data concerning refractory pain will be used to underscore the importance of central processing of pain, with particular emphasis on neuropsychological and cognitive function and capacity that may play important roles in pain processing and maintenance of the pain state. Further, neurophysiological data showing that the anterior cingulate cortex (ACC) and other structures in the brain may play key roles in modulation of chronic pain will also be discussed. Although peripheral triggering events surely play an important role in initiating pain, the development of chronic and, in particular, refractory pain may depend on changes or malfunctions in the central nervous system. These changes may be quite subtle and require sophisticated approaches, such as functional MRI, to study them, as is now being done. New findings obtained therefore may lead to more rational and reliable treatment for orofacial pain.
authors.affiliation: Department of Dentistry, Wasser Pain Management Centre, Mount Sinai Hospital, Toronto, ON, Canada. howard.tenenbaum@utoronto.ca
authors.forename: H C
authors.initials: HC
authors.lastname: Tenenbaum
authors.forename: D
authors.initials: D
authors.lastname: Mock
authors.forename: A S
authors.initials: AS
authors.lastname: Gordon
authors.forename: M B
authors.initials: MB
authors.lastname: Goldberg
authors.forename: M L
authors.initials: ML
authors.lastname: Grossi
authors.forename: D
authors.initials: D
authors.lastname: Locker
authors.forename: K D
authors.initials: KD
authors.lastname: Davis
mesh_terms: D000063:Accidents, Traffic; D000344:Afferent Pathways / Q000502:physiology; D002908:Chronic Disease; D006259:Craniocerebral Trauma / Q000150:complications; D005157:Facial Pain / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology*; D006801:Humans; D019964:Mood Disorders / Q000150:complications; D019838:Neck Injuries / Q000150:complications; D009437:Neuralgia / Q000503:physiopathology; D009483:Neuropsychological Tests; D009619:Nociceptors / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology; D013705:Temporomandibular Joint Disorders / Q000150:complications / Q000209:etiology / Q000523:psychology / Q000628:therapy