[A successive study of histopathological changes in unilateral facial muscle denervation].
OBJECTIVE
To observe the histopathological changes in unilateral facial muscle denervation.


METHODS
Gomori trichrome stain, acridine orange (AO) fluorescence, enzyme-histochemistry and immunohistochemistry techniques were used for studying mitochondria, nuclei acid concentration, enzymatic activity and contraction protein expression of facial muscle in different denervation period.


RESULTS
Mitochondrian function, enzymatic activity and contraction protein expression of facial muscle denervation increased in the first two weeks, then declined till 6 months. Myofiber's histotype began to transform in 1 month after denervation. Type-grouping was obvious in 6 month. Regeneration myofibers were also seen at this time.


CONCLUSIONS
Unilateral facial muscles become atrophy after denervation. They have proliferating tendency from 2 month to 6 month. Therefore, within 1 month after denervation measures to benefit atrophy will be more effective.
Xiao
R
R
Department of Oral Maxillofacial Surgery, Peking University School of Stomatology, Beijing 100081, China.
Yu
G
G
Jia
H
H
D000818:Animals; D001284:Atrophy; D003714:Denervation; D005152:Facial Muscles / Q000737:chemistry / Q000294:innervation* / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D011817:Rabbits