[Study on the role of human papillomavirus in carcinogenesis of oral papillomas by in situ hybridization].
OBJECTIVE
To explore the role of human papillomavirus (HPV) infection on carcinogenesis of oral squamous cell papillomas (SCP).


METHODS
By using digoxin labelled HPV 6/11 and HPV 16/18 probes, through hybridization in situ technique, the HPV DNA sequence in 30 cases of oral SCP were detected.


RESULTS
Among them, 16 cases (53.3%) were positive for HPV 6/11 DNA. None of cases of SCP were positive for HPV 16/18 DNA.


CONCLUSIONS
Our results show that the frequent finding of HPV 6/11 DNA in oral SCP had close association between oral papillomas and HPV 6/11 infection.
Bu
J
J
Department of Stomatology, General Hospital of PLA, Beijing 100853, China.
Pang
J
J
Bu
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000821:virology*; D010212:Papilloma / Q000821:virology*; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*
D004279:DNA, Viral