title: Chemo-radiotherapy in locally advanced squamous cell carcinoma of the head and neck: factors affecting toxicity patterns.
abstract: Radiation and chemotherapy in the treatment of locally advanced squamous carcinoma of the head and neck can be used according to different strategies: concomitant, alternation, consecutive. The limiting acute toxicity is local with the radiosensitizing capacity of the drug and type of radiation fractionation being the predominant factors. Regimens providing more that 50% of complete responses are usually associate with a more than 40% incidence of severelocal reaction. More information is needed on late toxicity that influences the quality of life for these patients.
authors.affiliation: UO di Odontoiatria, Istituto Scientifico San Raffaele, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rosso
authors.forename: M
authors.initials: M
authors.lastname: Benasso
authors.forename: R
authors.initials: R
authors.lastname: Rosso
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects*