[The effects of high dose atropine on function of isolated diaphragmatic preparation of rats with omethoate poisoning].
OBJECTIVE
The study was designed to examine the influence of high dose atropine on respiratory muscle of rat isolated phrenic diaphragm.


METHODS
Rats were divided into 2 groups: (1) a toxic group administered with 2LD(50) omethoate, SC. (2) a contrast group with 0.9% NS, SC. The function of isolated rat phrenic diaphragm was observed by MS-302 analysis instrument physiologically and pharmacologically.


RESULTS
In both groups the function of isolated rat phrenic diaphragm was significantly reduced with atropine dose increasing gradually to 0.6 mg (P < 0.01). When the atropine dose amounted to 0.8 mg. The function of isolated rat phrenic diaphragm almost disappeared in the picture. When the atropine in the diaphragm was weed out, the function of isolated rat phrenic diaphragm recovered completely in 50 minutes.


CONCLUSIONS
It is suggested that the cause of respiratory muscle paralysis may be related to high dose of atropine.
Qiu
Z
Z
The Department of Emergency, Beijing 307 Hospital, Beijing 100039, China.
Zhao
D
D
Shi
Y
Y
Liu
Y
Y
D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000633:toxicity*; D004117:Dimethoate / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D008297:Male; D009119:Muscle Contraction; D010791:Phrenic Nerve / Q000502:physiology; D051381:Rats; D012132:Respiratory Muscles / Q000187:drug effects*; D012133:Respiratory Paralysis / Q000150:complications
C002302:dimethoxon; D001285:Atropine; D004117:Dimethoate