Hedgehog patterns midbrain ARChitecture.
Recent work from Agarwala et al. has uncovered exquisite ventral patterning in the mesencephalon. Using electroporation in chicks, they show that ectopic expression of Sonic Hedgehog (Shh) in dorsal mesencephalon can recapitulate this patterning in its entirety. These results are discussed in the context of the purported role of Shh as a morphogen.
Machold
Robert
R
Developmental Genetics Program and the Dept of Cell Biology, The Skirball Institute of Biomolecular Medicine, NYU Medical Center, 540 First Avenue, NY 10016, USA.
Fishell
Gord
G
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D002642:Chick Embryo; D004627:Embryonic Induction / Q000502:physiology; D053823:Hedgehog Proteins; D006801:Humans; D008636:Mesencephalon / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009672:Notochord / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; C509239:SHH protein, human; D015534:Trans-Activators