Biodistribution of 99mTc-O4Na changes in adult rats whose mothers were malnourished during lactation.
99mTc-O4Na biodistribution changes in malnourished adults rats. We evaluated this biodistribution in rats whose mothers were malnourished during lactation.


METHODS
On the first day of lactation the mothers were separated into 3 groups: control (C) group, protein-restricted (PR) group, and energy-restricted (ER) group. After weaning all pups received a control diet until 60 d, when they were injected with 99mTc-O4Na and killed after 30 min. We evaluated the absolute percentage injected dose (%ID) and the %ID per gram (%ID/g) in thyroid, stomach, heart, bone, kidney, lung, liver, brain, and testes.


RESULTS
In the PR group, the %ID and %ID/g were significantly higher in the stomach and lower in the thyroid than in the C group. In the ER pups, the %ID and %ID/g were higher in the liver, stomach, and testes than in the C group.


CONCLUSIONS
The mother's nutritional status during lactation affects the biodistribution of 99mTc-O4Na in the offspring, and this condition must be considered when nuclear medicine examinations are indicated.
Passos
Magna Cottini Fonseca
MC
Departamento de Nutrição Aplicada, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil. magna@uerj.br
Ramos
Cristiane F
CF
Dutra
Sheila C P
SC
Bernardo-Filho
Mario
M
Moura
Egberto Gaspar
EG
D000818:Animals; D005260:Female; D007774:Lactation / Q000502:physiology*; D008297:Male; D009748:Nutrition Disorders / Q000503:physiopathology*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m