Differential response of synaptic zinc levels to sensory deprivation in the barrel cortex of young and adult mice.
The distribution of synaptic zinc after short-term (up to 48 h) tactile deprivation of vibrissae was investigated in the barrel cortex of mice using histochemical staining. In adult mice, 12 h after trimming selected rows of vibrissae, an increase in zinc staining in the deprived barrels was observed. This increase was still present 48 h after trimming. These results indicate that the level of synaptic zinc is rapidly regulated by neuronal activity in adult mice. In young (8-day-old) mice, the short-term deprivation did not alter zinc staining and only chronic sensory deprivation produced an increase in zinc staining. However, after long-term deprivation no changes were found in adult mice. These results suggest that different mechanisms might be involved in functional reorganization of zinc containing terminals in young and fully mature cerebral cortex.
Czupryn
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Department of Neurophysiology, The Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland.
Skangiel-Kramska
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J
D000344:Afferent Pathways / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D006651:Histocytochemistry; D051379:Mice; D009473:Neuronal Plasticity / Q000502:physiology*; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D012683:Sensory Deprivation / Q000502:physiology*; D013003:Somatosensory Cortex / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology; D015854:Up-Regulation / Q000502:physiology; D014738:Vibrissae / Q000502:physiology*; D015032:Zinc / Q000378:metabolism*
D015032:Zinc