title: Physical characteristics of Vivostat patient-derived sealant. Implications for clinical use.
abstract: This study compared the physical characteristics of Vivostat patient-derived sealant with two conventional fibrin sealants, Tissucol and Beriplast. Vivostat sealant exhibited greater elasticity without compromising tensile strength. Vivostat sealant polymerised at low temperatures (4 and 25 degrees C) or at high temperature (70 degrees C) exhibited similar viscoelastic properties as when polymerised at normal physiological temperature (37 degrees C). Vivostat fibrin I solution can be stored at room temperature for up to 8 h without affecting the mechanical properties of the derived sealant. These physical characteristics of Vivostat patient-derived sealant suggest that it may have suitable stability and performance characteristics for use in a wide range of surgical procedures.
authors.affiliation: ConvaTec Advanced Technology Development, Deeside, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Velada
authors.forename: D A
authors.initials: DA
authors.lastname: Hollingsbee
mesh_terms: D001331:Automation; D001769:Blood; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004864:Equipment and Supplies; D015718:Fibrin Tissue Adhesive / Q000737:chemistry*; D006801:Humans; D008838:Microcomputers; D010361:Patients; D011108:Polymers; D011309:Preservation, Biological; D013696:Temperature; D013718:Tensile Strength; D013997:Time Factors
chemical_list: D015718:Fibrin Tissue Adhesive; D011108:Polymers