[Association between estrogen receptor gene polymorphisms and acute myocardial infraction].
OBJECTIVE
To study the distribution of estrogen receptor (ER) in Chinese Hans population and the association of ER gene polymorphisms with acute myocardial infarction (AMI).


METHODS
ER genotyping was performed in 75 AMI patients and 118 controls by PCR-RFLP. The serum lipid levels of the subjects were also determined. 46 AMI patients were examined by selected coronary angiography (SCA).


RESULTS
ER allelic frequencies of X, x and P, p alleles were 0.207, 0.793; 0.169, 0.831 and 0.287, 0.713; 0.399, 0.661 in AMI and control groups respectively. There was no significant difference between the distribution of Xbal and PvaII polymorphisms in AMI group and control group (P > 0.05). The serum lipid levels and the results of SCA were also not significantly difference among genotypes in intra-group. But the distributions of PvuII genotypes were significantly different between AMI group and controls (P < 0.05).


CONCLUSIONS
XbaI polymorphisms are not related to AMI. But PvuII polymorphisms are associated with AMI, they might be a risk factor for AMI.
Li
Y
Y
Department of Laboratory Science, Renmin Hospital, Wuhan University, Wuhan 430060, China.
Huang
X
X
Zhang
P
P
D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*
D008055:Lipids; D011960:Receptors, Estrogen