Functional genomic research of alpha 1-adrenoceptors.
The Human Genome Project is now almost completed, and we are about to move into the post-genome sequence era of functional genomics. The advent of genome science has markedly changed the way life science research including pharmacological study is conducted; thus, systematic and integrated 'genome-wide' survey is feasible. The stream of 'Genome-->Transcriptome--> Proteomics' is logical and, in each aspect, approaches for functional genomics are now pursued at a high pace. We have recently developed a standardized technical platform (in various levels, such as transcription, cell and whole animal levels, etc.), and applied these techniques to the study of functional genomics of G-protein-coupled receptors, particularly alpha1-adrenoceptors as a model. Combining the genome information and technology, future pharmacological studies would become the genome-based search and research.
Tsujimoto
G
G
Department of Molecular Cell Pharmacology, National Children's Medical Research Center, Tokyo, Japan. gtsujimoto@nch.go.jp
Katsuma
S
S
Shiojima
S
S
Hirasawa
A
A
Tanoue
A
A
D000818:Animals; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic / Q000235:genetics
D018340:Receptors, Adrenergic, alpha-1