title: Conservation of protein interaction network in evolution.
abstract: A functional analysis of protein fold interaction suggested that structural fold families have gradually acquired more diverse interacting partners while maintaining central biochemical interactions and functions. This means that the protein interaction network (map) maintains its robust architecture due to the functional constraints associated with the interactions.
authors.affiliation: MRC-DUNN Human Nutrition Unit, Hills Road, Cambridge, CB22XY, England, UK. jong@mrc-dunn.cam.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Park
authors.forename: D
authors.initials: D
authors.lastname: Bolser
mesh_terms: D001665:Binding Sites; D019295:Computational Biology; D030562:Databases, Protein; D019143:Evolution, Molecular; D046911:Macromolecular Substances; D011485:Protein Binding; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D046911:Macromolecular Substances; D011506:Proteins