Morphologic changes leading to bronchiolitis obliterans in a patient with delayed non-infectious lung disease after allogeneic bone marrow transplantation.
A 37-year-old man developed delayed non-infectious lung disease after undergoing bone marrow transplantation (BMT) for acute myeloid leukaemia. Over a 15-month period, the progression of morphologic changes from cellular interstitial pneumonia to bronchiolitis obliterans organizing pneumonia and cicatricial bronchiolitis obliterans was documented. Pulmonary function tests, high-resolution CT, bronchoalveolar lavage, lung biopsy and extensive microbiological studies were used as diagnostic tools either at onset and during the follow-up. This represents the first reported case in which a model--supported by longitudinal biopsy results--for the evolution of histologic lesions toward bronchiolitis obliterans after BMT is suggested; therapeutic implications are discussed.
Trisolini
R
R
Department of Thoracic Diseases, Maggiore Hospital, Largo Nigrisoli 2, 40100 Bologna, Italy.
Bandini
G
G
Stanzani
M
M
Chilosi
M
M
Cancellieri
A
A
Boaron
M
M
Poletti
V
V
D000328:Adult; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001989:Bronchiolitis Obliterans / Q000209:etiology*; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D014184:Transplantation, Homologous