A pedigree partitioning approach to quantitative trait loci mapping of IgE serum level in the GAW12 Hutterite data.
We present a semi-automatic method that uses principles from factor analysis to subdivide large pedigrees into smaller, non-overlapping sub-pedigrees. Application of our method to the Genetic Analysis Workshop 12 Hutterite pedigree yielded 12 sub-pedigrees that were used to carry out a genome-wide linkage scan for IgE serum level in SOLAR. Two-point analyses resulted in strong evidence for linkage to two marker loci on chromosome 1, D1S3723 (lod = 3.70) and D1S534 (lod = 3.58). Multipoint analysis resulted in a maximum lod of 4.58 on chromosome 1 at 143 cM. After extending the two pedigrees that contributed the most evidence for linkage, the maximum lod score decreased to 4.18, with most of the evidence for linkage due to a single large sub-pedigree.
Pankratz
V S
VS
Section of Biostatistics, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.
Iturria
S J
SJ
D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D003241:Consanguinity; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D019655:Quantitative Trait, Heritable; D013023:South Dakota
D007073:Immunoglobulin E