title: Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation.
abstract: BACKGROUND
  Radiotherapy prevents local recurrence of breast cancer after breast-conserving surgery. We evaluated the effect of a supplementary dose of radiation to the tumor bed on the rates of local recurrence among patients who received radiotherapy after breast-conserving surgery for early breast cancer.
  
  
  METHODS
  After lumpectomy and axillary dissection, patients with stage I or II breast cancer received 50 Gy of radiation to the whole breast in 2-Gy fractions over a five-week period. Patients with a microscopically complete excision were randomly assigned to receive either no further local treatment (2657 patients) or an additional localized dose of 16 Gy, usually given in eight fractions by means of an external electron beam (2661 patients).
  
  
  RESULTS
  During a median follow-up period of 5.1 years, local recurrences were observed in 182 of the 2657 patients in the standard-treatment group and 109 of the 2661 patients in the additional-radiation group. The five-year actuarial rates of local recurrence were 7.3 percent (95 percent confidence interval, 6.8 to 7.6 percent) and 4.3 percent (95 percent confidence interval, 3.8 to 4.7 percent), respectively (P<0.001), yielding a hazard ratio for local recurrence of 0.59 (99 percent confidence interval, 0.43 to 0.81) associated with an additional dose. Patients 40 years old or younger benefited most; at five years, their rate of local recurrence was 19.5 percent with standard treatment and 10.2 percent with additional radiation (hazard ratio, 0.46 [99 percent confidence interval, 0.23 to 0.89]; P=0.002). At five years in the age group 41 to 50 years old, no differences were found in rates of metastasis or overall survival (which were 87 and 91 percent, respectively).
  
  
  CONCLUSIONS
  In patients with early breast cancer who undergo breast-conserving surgery and receive 50 Gy of radiation to the whole breast, an additional dose of 16 Gy of radiation to the tumor bed reduces the risk of local recurrence, especially in patients younger than 50 years of age.
authors.affiliation: Department of Radiation Oncology, the Netherlands Cancer Institute, Amsterdam. h.bartelink@nki.nl
authors.forename: H
authors.initials: H
authors.lastname: Bartelink
authors.forename: J C
authors.initials: JC
authors.lastname: Horiot
authors.forename: P
authors.initials: P
authors.lastname: Poortmans
authors.forename: H
authors.initials: H
authors.lastname: Struikmans
authors.forename: W
authors.initials: W
authors.lastname: Van den Bogaert
authors.forename: I
authors.initials: I
authors.lastname: Barillot
authors.forename: A
authors.initials: A
authors.lastname: Fourquet
authors.forename: J
authors.initials: J
authors.lastname: Borger
authors.forename: J
authors.initials: J
authors.lastname: Jager
authors.forename: W
authors.initials: W
authors.lastname: Hoogenraad
authors.forename: L
authors.initials: L
authors.lastname: Collette
authors.forename: M
authors.initials: M
authors.lastname: Pierart
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000517:prevention & control* / Q000628:therapy; D009367:Neoplasm Staging; D011785:Quality Assurance, Health Care; D016879:Salvage Therapy; D016019:Survival Analysis