[A study on the effect of house dust mite on interleukin-10 secretion of peripheral blood lymphocytes in patients with allergic asthma].
OBJECTIVE
To investigate the relationship between interleukin (IL)-10 and allergic asthma, and the effect of antigen on IL-10.


METHODS
The supernatant of cultured peripheral blood lymphocytes (PBLC) from 20 patients with allergic asthma and 20 normal subjects with different stimuli [home-dust-mite (HDM) or dexamethasone] was determined for IL-10, by means f enzyme-linked immunosorbent assay.


RESULTS
(1) IL-10 was significantly decreased in asthma group, as compared with the control group (P < 0.01); (2) Less IL-10 was released in HDM-stimulated PBLC in asthma (P < 0.01); (3) IL-10 was obviously increased in dexamethason-stimulated whether in the asthma or in the control group.


CONCLUSIONS
The diminished IL-10 production from PBLC could be related to asthmatic attack in patients with allergic asthma. Dexamethason might exert, at least, a part of anti-inflammatory activity by inducing IL-10 secretion of PBLC.
Song
M
M
Division of Respiratory Medicine, The Second Hospital, Shanxi Medical University, Taiyuan 030001.
Li
J
J
Yang
B
B
Liu
Z
Z
Zhang
Y
Y
D000293:Adolescent; D000328:Adult; D000818:Animals; D001249:Asthma / Q000276:immunology*; D002478:Cells, Cultured; D002648:Child; D003907:Dexamethasone / Q000494:pharmacology; D004391:Dust; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology*
D004391:Dust; D016753:Interleukin-10; D003907:Dexamethasone