Developmental toxicity study of pentachlorophenol in the rabbit.
The potential for developmental toxicity of pentachlorophenol (penta) was studied in New Zealand white rabbits at doses of 0 (corn oil), 7.5, 15, and 30 mg/kg/day administered by gavage on days 6 to 18 of gestation. The rabbits were sacrificed on day 29 of presumed gestation and necropsied. Measurements included number of corpora lutea, pregnancy, number and distribution of implantations, early and late resorptions, live and dead fetuses, fetal weight, gender, and gross external, soft tissue, and skeletal alterations. The mid and high doses reduced maternal body weight gain; the high dose caused transient weight loss and reduced feed consumption. There were no effects on embryofetal development at any of the doses evaluated. Based on these data, the maternal no-observable-adverse-effect level (NOAEL) is 7.5 mg/kg/day, while the developmental NOAEL is 30 mg/kg/day. Penta is not a developmental toxicant in a nonrodent animal model.
Bernard
B K
BK
SRA International, Inc, Washington, DC 20036, USA. bernard@sra-intl.com
Ranpuria
A K
AK
Hoberman
A M
AM
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced*; D007441:Intubation, Gastrointestinal; D008098:Litter Size / Q000187:drug effects*; D018811:Maternal Exposure; D019055:No-Observed-Adverse-Effect Level; D010416:Pentachlorophenol / Q000633:toxicity*; D011247:Pregnancy; D011817:Rabbits; D012744:Sex Ratio
D004785:Environmental Pollutants; D010416:Pentachlorophenol