title: Larynx-preserving pharyngo-esophagectomy after chemoradiation in the treatment of cancer of the pharyngo-esophageal junction.
abstract: Pharyngo-laryngo-esophagectomy in the treatment of advanced tumors of the pharyngo-esophageal junction is associated with a high morbidity and poor quality of life due to loss of the larynx. Neoadjuvant chemoradiotherapy resulted in a considerable tumor reduction in 6 patients allowing radical tumor resection by larynx-preserving pharyngo-esophagectomy. The operation consisted of total esophagectomy and resection of the posterior pharyngeal wall and reconstruction by a pharyngogastrostomy in 5 patients, and ileocolon interposition in 1 patient.
authors.affiliation: Department of Surgery, University of Pécs, Hungary. ophorvath@iseb.pote.hu
authors.forename: O P
authors.initials: OP
authors.lastname: Horváth
authors.forename: L
authors.initials: L
authors.lastname: Cseke
authors.forename: K
authors.initials: K
authors.lastname: Kalmár
authors.forename: G
authors.initials: G
authors.lastname: Varga
authors.forename: G
authors.initials: G
authors.lastname: Horváth
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D016629:Esophagectomy; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007825:Laryngectomy; D020360:Neoadjuvant Therapy; D010610:Pharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D010611:Pharyngectomy
chemical_list: D016190:Carboplatin; D005472:Fluorouracil