title: Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro.
abstract: We have observed that human neutrophils (polymorphonuclear leukocytes [PMNs]) have an increased growth-inhibitory and killing effect on a strain of Candida albicans with a deletion of CHK1, a gene encoding a putative histidine kinase. The PMN effect was not due to increased phagocytosis of the null strain. This observation may partially explain the reduced virulence in a hematogenously disseminated murine model of candidiasis.
authors.affiliation: Istituto Superiore di Sanita, Laboratory of Bacteriology and Mycology, Viale Regina Elena 299, Rome 00196, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Torosantucci
authors.forename: Paola
authors.initials: P
authors.lastname: Chiani
authors.forename: Flavia
authors.initials: F
authors.lastname: De Bernardis
authors.forename: Antonio
authors.initials: A
authors.lastname: Cassone
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Calera
authors.forename: Richard
authors.initials: R
authors.lastname: Calderone
mesh_terms: D002176:Candida albicans / Q000201:enzymology* / Q000276:immunology; D002478:Cells, Cultured; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D000071677:Histidine Kinase; D006801:Humans; D009504:Neutrophils / Q000166:cytology / Q000276:immunology* / Q000382:microbiology; D010587:Phagocytosis / Q000276:immunology*; D011494:Protein Kinases / Q000276:immunology*
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D011494:Protein Kinases; D000071677:Histidine Kinase