[A clinical trial of 14 and 15 membered macrolides in treating six cases of diffuse panbronchiolitis].
OBJECTIVE
To observe the therapeutic effect of macrolides in treating diffuse panbronchiolitis (DPB).


METHODS
14- and 15-ring macrolides were used in the treatment of six confirmed cases of DPB for 3 approximately 24 months. The improvement in symptoms, X-ray findings, lung function and results of blood gas analysis was recorded.


RESULTS
Symptoms such as cough, sputum expectoration and exertional dyspnea alleviated significantly during the first 2 weeks. PaO(2) level, FEV(1)%, and vital capacity (VC) increased remarkably. Diffuse small nodular lesions on chest X-ray or CT decreased in size within a few months.


CONCLUSIONS
Macrolides have significant therapeutic effect on DPB and the patients have good tolerance to them. However, the mechanism of its action, the selection of the best macrolide, the most suitable dosage and the appropriate period of treatment still need further investigation.
Liu
Y
Y
Department of Pulmonary Medicine, Chinese PLA General Hospital, Beijing 100853.
Hu
H
H
Zhang
J
J
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use*; D001988:Bronchiolitis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D018942:Macrolides