title: The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients.
abstract: The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69+/-5.63 years; mean Hamilton Rating Scale for Depression score: 21+/-2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that the high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.
authors.affiliation: Department of Neurology, Butler Hospital Providence, RI 02906, USA. Stephen_Salloway@Brown.edu
authors.forename: Stephen
authors.initials: S
authors.lastname: Salloway
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Boyle
authors.forename: Stephen
authors.initials: S
authors.lastname: Correia
authors.forename: Paul F
authors.initials: PF
authors.lastname: Malloy
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Cahn-Weiner
authors.forename: Lon
authors.initials: L
authors.lastname: Schneider
authors.forename: K Ranga Rama
authors.initials: KR
authors.lastname: Krishnan
authors.forename: Raj
authors.initials: R
authors.lastname: Nakra
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000473:pathology*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020280:Sertraline / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D020280:Sertraline