title: Localized 2D correlation spectroscopy in human brain at 3 T.
abstract: The purpose of this study was to acquire a localized 2D (two-dimensional) 1H correlation spectrum, in a volume of interest reasonably small, and within an experiment time compatible with clinical applications. A modified PRESS technique has been used. The last 180 degrees pulse of the PRESS sequence has been converted into a 90 degrees pulse for both refocusing and coherence transfer. 2D correlation spectroscopy was performed on healthy volunteers in a clinical magnet, at 3 T, within 34 min, for a voxel size of 27 cm3. This result makes it possible to consider clinical applications.
authors.affiliation: Unité mixte INSERM, Université J. Fourier U438 'RMN Bioclinique', LRC CEA, CHU pavillon B, BP 217, 38043 Cedex 9, Grenoble, France. anne.ziegler@ujf-grenoble.fr
authors.forename: Anne
authors.initials: A
authors.lastname: Ziegler
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gillet
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Beloeil
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Macher
authors.forename: Michel
authors.initials: M
authors.lastname: Décorps
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Nédelec
mesh_terms: D001921:Brain / Q000473:pathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D013053:Spectrophotometry; D013997:Time Factors