title: [Factors associated with refusal of organ donation in France from 1996 to 1999].
abstract: OBJECTIVE
  The demand for organ transplantation exceeds organ donation in France and refusal to organ donation remains close to 30%. This study analysed risk factors associated with refusal of organ donation.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  All potential organ donors registered by the French transplantation agency between 1996 and 1999 were included, excepted those with a contraindication to organ procurement or a logistic problem: 5,911 donors were included.
  
  
  METHODS
  Data analysed were those collected routinely on the French database. A logistic model was used to identify statistically significant factors and a stepwise procedure was performed to identify independent factors linked with refusal.
  
  
  RESULTS
  In univariate analysis, age > 60 years and age < 13 years, stroke, lack of suicide, localisation in an university hospital and in others regions than the Centre-East of France were associated with a higher refusal rate. Year of harvesting, low level of organ procurement activity were not associated with refusal. In multivariate analysis, factors independently associated with refusal were age > 60 years [Odds-Ratio (OR) = 1.2)] or age < 13 years (OR = 1.5), stroke (OR = 1.2), meningitis and cranial tumour (OR = 1.4), suicide (OR = 0.5) and others French regions than Centre-East.
  
  
  CONCLUSIONS
  The risk factors described should be taking into account when family's members are approached for donation. They represent the interactions between the history of the donors, harvesting organisation, and sociocultural factors.
authors.affiliation: Etablissement français des greffes, 75012 Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Demiguel
authors.forename: C
authors.initials: C
authors.lastname: Boileau
authors.forename: S
authors.initials: S
authors.lastname: Cohen
authors.forename: D
authors.initials: D
authors.lastname: Noury
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
authors.forename: P
authors.initials: P
authors.lastname: Tuppin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002423:Cause of Death; D002648:Child; D016208:Databases, Factual; D005260:Female; D005602:France; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement