Life extension in Drosophila by feeding a drug.
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.
Kang
Hyung-Lyun
HL
Neurogenetics Branch, MSC1250, 10/3B12, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Benzer
Seymour
S
Min
Kyung-Tai
KT
D000107:Acetylation; D000818:Animals; D004330:Drosophila / Q000187:drug effects* / Q000235:genetics / Q000502:physiology*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D017344:Genes, Insect / Q000187:drug effects; D006657:Histones / Q000378:metabolism; D008136:Longevity / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D008297:Male; D010654:Phenylbutyrates / Q000494:pharmacology*
D006657:Histones; D010654:Phenylbutyrates; C075773:4-phenylbutyric acid