title: Antiviral Chinese medicinal herbs against respiratory syncytial virus.
abstract: Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC(50)) ranging from 6.3 to 52.1 microg/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components.
authors.affiliation: Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: Shuang-Cheng
authors.initials: SC
authors.lastname: Ma
authors.forename: Jiang
authors.initials: J
authors.lastname: Du
authors.forename: Paul Pui-Hay
authors.initials: PP
authors.lastname: But
authors.forename: Xue-Long
authors.initials: XL
authors.lastname: Deng
authors.forename: Yong-Wen
authors.initials: YW
authors.lastname: Zhang
authors.forename: Vincent Eng-Choon
authors.initials: VE
authors.lastname: Ooi
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
authors.forename: Spencer Hon-Sun
authors.initials: SH
authors.lastname: Lee
authors.forename: Song Fong
authors.initials: SF
authors.lastname: Lee
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects / Q000502:physiology; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy / Q000379:methods / Q000706:statistics & numerical data; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000254:growth & development; D029909:Sophora / Q000737:chemistry; D014407:Tumor Cells, Cultured; D047310:Apigenin
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; D010936:Plant Extracts; C458179:scutellarein; D047310:Apigenin