title: The next step from high-flux dialysis: application of sorbent technology.
abstract: The current foci of renal replacement therapy with dialysis are middle molecular weight toxins, consisting of small proteins, polypeptides and products of glycosylation and lipoxygenation. Conventional high-flux dialysis is not efficient at removing these molecules, explaining the increased interest in using sorbents to supplement dialysis techniques. Prototype biocompatible sorbents have been developed and investigated for middle molecule removal; these have been shown, in man, to remove beta(2)-microglobulin, angiogenin, leptin, cytokines and other molecules, without reducing platelets and leukocytes. Extensive clinical studies are underway to demonstrate the clinical utility and safety of adding routinely a sorbent hemoperfusion device to hemodialysis.
authors.affiliation: RenalTech International, New York, NY 10021, USA. jamesw@renaltech.com
authors.forename: James F
authors.initials: JF
authors.lastname: Winchester
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
authors.forename: James A
authors.initials: JA
authors.lastname: Brady
authors.forename: Larry D
authors.initials: LD
authors.lastname: Cowgill
authors.forename: Jamie
authors.initials: J
authors.lastname: Salsberg
authors.forename: Eric
authors.initials: E
authors.lastname: Yousha
authors.forename: Mike
authors.initials: M
authors.lastname: Choquette
authors.forename: Robert
authors.initials: R
authors.lastname: Albright
authors.forename: Jonathan
authors.initials: J
authors.lastname: Clemmer
authors.forename: Vadim
authors.initials: V
authors.lastname: Davankov
authors.forename: Maria
authors.initials: M
authors.lastname: Tsyurupa
authors.forename: Ludmila
authors.initials: L
authors.lastname: Pavlova
authors.forename: Mikhail
authors.initials: M
authors.lastname: Pavlov
authors.forename: Gerald
authors.initials: G
authors.lastname: Cohen
authors.forename: Walter
authors.initials: W
authors.lastname: Hörl
authors.forename: Frank
authors.initials: F
authors.lastname: Gotch
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Levin
mesh_terms: D000327:Adsorption; D000818:Animals; D006464:Hemoperfusion / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D006801:Humans; D017582:Renal Replacement Therapy / Q000379:methods; D012117:Resins, Synthetic / Q000627:therapeutic use; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D012117:Resins, Synthetic; D001613:beta 2-Microglobulin