title: Metabolic treatment of hyperuricosuric autism.
abstract: A single male subject with hyperuricosuric autism was treated for a period of 2 years with an oral dose of uridine, which increased from 50 to 500 mg/kg/day. This patient experienced dramatic social, cognitive, language, and motor improvements. These improvement decreased within 72 h of the discontinuation of uridine, but reappeared when uridine supplementation was resumed. Thus, it appears that patients with hyperuricosuric autism benefit from metabolic therapy with oral uridine therapy in a manner similar to that seen in other disorders of purine metabolism in which there is autistic symptomatology.
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla 92093-0624, USA.
authors.forename: Theodore
authors.initials: T
authors.lastname: Page
authors.forename: Charles
authors.initials: C
authors.lastname: Moseley
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001321:Autistic Disorder / Q000188:drug therapy* / Q000523:psychology / Q000652:urine*; D002648:Child; D006801:Humans; D008297:Male; D014527:Uric Acid / Q000378:metabolism / Q000652:urine*; D014529:Uridine / Q000627:therapeutic use*
chemical_list: D014527:Uric Acid; D014529:Uridine