title: Study on PDGF receptor beta pathway in glomerular formation in neonate mice.
abstract: The assembly of vascular endothelial cells (ECs) and smooth muscle cells is a critical event in the development of the cardiovascular system. Although the role of ECs in this event has been studied intensively, the cross-talk between the two cell components remains poorly understood. In this study, we blocked platelet-derived growth factor receptor (PDGFR) pathways in mice by antagonistic rat monoclonal antibody APB5 against murine PDGFR-beta and examined glomerular capillary formation.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sano
authors.forename: M
authors.initials: M
authors.lastname: Yokode
authors.forename: N
authors.initials: N
authors.lastname: Takakura
authors.forename: G
authors.initials: G
authors.lastname: Takemura
authors.forename: T
authors.initials: T
authors.lastname: Doi
authors.forename: H
authors.initials: H
authors.lastname: Kataoka
authors.forename: T
authors.initials: T
authors.lastname: Sudo
authors.forename: S
authors.initials: S
authors.lastname: Nishikawa
authors.forename: H
authors.initials: H
authors.lastname: Fujiwara
authors.forename: S I
authors.initials: SI
authors.lastname: Nishikawa
authors.forename: T
authors.initials: T
authors.lastname: Kita
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000254:growth & development*; D051379:Mice; D051381:Rats; D020239:Receptor Cross-Talk; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D000911:Antibodies, Monoclonal; D020797:Receptor, Platelet-Derived Growth Factor beta