title: [Klion D - possibilities of prophylaxis and treatment during pregnancy].
abstract: OBJECTIVE
  To evaluated and dilated possibilities of prophylaxis and treatment of agent Klioton D in pregnant women.
  
  
  METHODS
  164 women were evaluated for 1.5 year period between 12 and 40 gest. week. The first group of prophylactic usage was consisted of 118 women, divided in two groups: prophylaxis before cerclage--33 women, between 12 and 20 gest. week, and prophylaxis before delivery--85 cases. The second group was therapeutic usage in 46 women between 16 and 34 gest. week.
  
  
  RESULTS
  Microbiologically superiority of unspecific bacterial agents was proved, mixed bacterial aerobic-anaerobic flora was dominated. More common bacterial vaginosis and candidosis were noted. In therapeutic group 80% were cured. The rate of subjective complaints in two groups was evaluated. Complications after delivery were 0.04%. Complications after cerclage weren't noted.
  
  
  CONCLUSIONS
  Microbiological type find in pregnant women and good prophylactic and the therapeutic results make Klion D as appropriate therapeutic agent before cerclage, delivery, in imminent abortions and premature labors.
authors.forename: B
authors.initials: B
authors.lastname: Vapinov
authors.forename: M
authors.initials: M
authors.lastname: Tsankova
authors.forename: R
authors.initials: R
authors.lastname: Velev
authors.forename: S
authors.initials: S
authors.lastname: Georgiev
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D023802:Cerclage, Cervical; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008825:Miconazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D014623:Vaginal Diseases / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D008825:Miconazole