Postanoxic generalized dystonia improved by bilateral Voa thalamic deep brain stimulation.
A patient with severe postanoxic dystonia and bilateral necrosis of the basal ganglia, who was confined to a wheelchair, underwent bilateral ventralis oralis anterior deep brain stimulation (Voa-DBS) after 6 weeks of unsuccessful bilateral pallidal DBS (GPi-DBS). After 4 months of high intensity Voa-DBS, cognitively unimpaired, he showed major improvement in dystonia, became ambulant, but committed suicide. Brain examination confirmed the correct location of the electrodes in GPi and Voa on both sides.
Ghika
J
J
Department of Neurology, Centre Hospitalia Universitaire Vaudois, Lausanne, Switzerland. joseph.ghika@chuv.hospvc.ch
Villemure
J G
JG
Miklossy
J
J
Temperli
P
P
Pralong
E
E
Christen-Zaech
S
S
Pollo
C
C
Maeder
P
P
Bogousslavsky
J
J
Vingerhoets
F
F
D000328:Adult; D001479:Basal Ganglia / Q000473:pathology; D004421:Dystonia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy*; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D013238:Stereotaxic Techniques; D013788:Thalamus / Q000502:physiology*