title: Experimental research on phospholipids variation of halothane on liver mitochondria.
abstract: AIM:To study the pathogenesis of hepatotoxicity of halothane.METHODS:The effect of different concentration of halothane and sevoflurane on mitochondrial membrane phospholipids composition of rat liver were analyzed using high performance liquid chromatography (HPLC) technology.RESULTS:Halothane at low concentration could degrade mitochondrial membrane major phospholipids and increase lysophosph-atidylcholine.CONCLUSION:The pathogenesis of halothane hepatotoxicity was the phospholipids variation on liver mitochondria.
authors.forename: Bo
authors.initials: B
authors.lastname: Sui
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Zhang
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Yu
authors.forename: Xue-Min
authors.initials: XM
authors.lastname: Wang
authors.forename: Yong-De
authors.initials: YD
authors.lastname: Ma
authors.forename: Shu-Xiao
authors.initials: SX
authors.lastname: Liu