title: Local detection of prostate cancer by positron emission tomography with 2-fluorodeoxyglucose: comparison of filtered back projection and iterative reconstruction with segmented attenuation correction.
abstract: BACKGROUND
  To compare filtered back projection (FBP) and iterative reconstruction with segmented attenuation correction (IRSAC) in the local imaging of prostate cancer by positron emission tomography with 2-fluorodeoxyglucose (FDG-PET).
  
  
  METHODS
  We retrospectively identified 13 patients with primary (n=7) or recurrent (n=6) prostate cancer who had increased uptake in the prostate on FDG-PET performed without urinary catheterization, contemporaneous biopsy confirming the presence of active tumor in the prostate, and correlative cross-sectional imaging by MRI (n=8) or CT (n=5). FDG-PET images were reconstructed by FBP and IRSAC. Two independent nuclear medicine physicians separately rated FBP and IRSAC images for visualization of prostatic activity on a 4-point scale. Results were compared using biopsy and cross-sectional imaging findings as the standard of reference.
  
  
  RESULTS
  IRSAC images were significantly better that FBP in terms of visualization of prostatic activity in 12 of 13 patients, and were equivalent in 1 patient (p<0.001, Wilcoxon signed ranks test). In particular, 2 foci of tumor activity in 2 different patients seen on IRSAC images were not visible on FBP images. In 11 patients who had a gross tumor mass evident on cross-sectional imaging, there was good agreement between PET and cross-sectional anatomic imaging with respect to tumor localization.
  
  
  CONCLUSIONS
  In selected patients, cancer can be imaged within the prostate using FDG-PET, and IRSAC is superior to FBP in image reconstruction for local tumor visualization.
authors.affiliation: Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: A
authors.initials: A
authors.lastname: Turlakow
authors.forename: S M
authors.initials: SM
authors.lastname: Larson
authors.forename: F
authors.initials: F
authors.lastname: Coakley
authors.forename: T
authors.initials: T
authors.lastname: Akhurst
authors.forename: M
authors.initials: M
authors.lastname: Gonen
authors.forename: H A
authors.initials: HA
authors.lastname: Macapinlac
authors.forename: W
authors.initials: W
authors.lastname: Kelly
authors.forename: S
authors.initials: S
authors.lastname: Leibel
authors.forename: J
authors.initials: J
authors.lastname: Humm
authors.forename: P
authors.initials: P
authors.lastname: Scardino
authors.forename: H
authors.initials: H
authors.lastname: Scher
authors.forename: H
authors.initials: H
authors.lastname: Hricak
mesh_terms: D000368:Aged; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18