The spliceosome: no assembly required?
In this issue of Molecular Cell, Stevens et al. purify a large particle from yeast extracts that contains all five of the U snRNPs required for pre-mRNA splicing. The existence of this "penta-snRNP" suggests the provocative possibility that spliceosome assembly does not depend upon a pre-mRNA substrate.
Nilsen
Timothy W
TW
Center for RNA Molecular Biology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, 44106, Cleveland, OH, USA
D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing; D017411:Ribonucleoproteins, Small Nuclear / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D017381:Spliceosomes / Q000235:genetics* / Q000378:metabolism
D012322:RNA Precursors; D017411:Ribonucleoproteins, Small Nuclear