PGP9.5 as a marker for invasive colorectal cancer.
OBJECTIVE
We proved recently that PGP9.5-negative pancreatic cancer patients had significantly better survival rates compared with those who were PGP9.5 positive, and PGP9.5 may be a novel marker for indicating the prognosis of pancreatic cancer patients. In this study, we examined the expression of PGP9.5 in primary colorectal cancers using immunohistochemistry and correlated the result with the clinicopathological features.


RESULTS
Of 74 colorectal cancer specimens examined, 33 cases (46%) showed positive staining with PGP9.5 in most tumor cells, whereas no PGP9.5 expression was detected in adjacent normal epithelium. Subsequently, we correlated PGP9.5 expression in tumors with the clinicopathological features of affected patients and found two significant differences in maximal tumor size and the extent of tumor (P = 0.035 and 0.019, respectively).


CONCLUSIONS
This result suggests that PGP9.5 expression is related to tumor progression and may be useful as a marker for invasive colorectal cancer.
Yamazaki
Taiji
T
Second Department of Surgery, Japan.
Hibi
Kenji
K
Takase
Tsunenobu
T
Tezel
Ekmel
E
Nakayama
Hiroshi
H
Kasai
Yasushi
Y
Ito
Katsuki
K
Akiyama
Seiji
S
Nagasaka
Tetsuro
T
Nakao
Akimasa
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015153:Blotting, Western; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011379:Prognosis; D012307:Risk Factors; D013869:Thiolester Hydrolases / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase
D014408:Biomarkers, Tumor; D009419:Nerve Tissue Proteins; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase