A closer look at proteolysis and MHC-class-II-restricted antigen presentation.
Antigen presentation by MHC class II molecules relies on the action of endocytic proteases, which are differentially expressed in antigen-presenting cells and are regulated by different components of the immune system. Endocytic enzymes process and convert exogenous antigens into peptidic determinants capable of interaction with MHC class II molecules. Chemical and genetic tools have recently been developed to study the role of lysosomal proteases in antigen presentation.
Lennon-Duménil
Ana-Maria
AM
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Bakker
Arnold H
AH
Wolf-Bryant
Paula
P
Ploegh
Hidde L
HL
Lagaudrière-Gesbert
Cécile
C
D000818:Animals; D017951:Antigen Presentation; D004705:Endocytosis / Q000276:immunology; D010450:Endopeptidases / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D051379:Mice; D010588:Phagosomes / Q000276:immunology; D020543:Proteome
D000949:Histocompatibility Antigens Class II; D020543:Proteome; D010450:Endopeptidases