[Effect of emodin on fibroblasts in lupus nephritis].
OBJECTIVE
To observe the effects of emodin on human fibroblasts in culture of kidney in patients with lupus nephritis (LN).


METHODS
Fibroblasts were isolated from culture of kidney of LN patients, and the effect of emodin on 3H-TdR incorporated rate of fibroblasts was observed. The apoptosis and c-myc gene expression were detected in the same time by flow cytometry.


RESULTS
Emodin could inhibit the proliferation of fibroblasts, and promote the programmed cell death through upregulate c-myc gene expression in human renal fibroblasts.


CONCLUSIONS
Emodin can inhibit proliferation and promote apoptosis of fibroblasts, which may be important in ameliorate interstitial fibrosis, thus improving prognosis of LN.
Liu
G
G
Department of Nephrology, Huizhou Central People's Hospital, Guangdong (516001).
Ye
R
R
Tan
Z
Z
D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004642:Emodin / Q000494:pharmacology*; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008181:Lupus Nephritis / Q000378:metabolism / Q000473:pathology*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; D004642:Emodin