title: Cardiac amyloidosis presenting with elevations of cardiac troponin I and angina pectoris.
abstract: We present the case of a 43-year-old male who was initially evaluated for angina pectoris and dyspnea. His CK, CK-MB, and cTnI were all elevated following a blood transfusion and he underwent coronary arteriography, which demonstrated no luminal obstructions. After several months, he was transferred to Mayo Clinic where diagnoses of fulminant cardiac amyloidosis and systemic multiple myeloma were established. The cTnI remained elevated despite normalization of the CK and CK-MB. Despite aggressive treatment, the patient died. Postmortem analysis demonstrated amyloid cardiac deposition including involvement of the coronary microvasculature. Electron microscopy revealed myocyte compression injury from amyloid infiltration. We believe this is the first report of elevated troponin I in a patient with cardiac amyloidosis. The electron microscopy in our case confirms cardiac damage as the mechanism for cTnI elevation. This observation strengthens our knowledge about the specificity of cTnI for the detection of cardiac injury.
authors.affiliation: Mayo Clinic and Foundation, Department of Internal Medicine, Rochester, Minnesota 55905, USA.
authors.forename: Ryan V
authors.initials: RV
authors.lastname: Cantwell
authors.forename: Ronnier J
authors.initials: RJ
authors.lastname: Aviles
authors.forename: Johannes
authors.initials: J
authors.lastname: Bjornsson
authors.forename: R Scott
authors.initials: RS
authors.lastname: Wright
authors.forename: William K
authors.initials: WK
authors.lastname: Freeman
authors.forename: Jae K
authors.initials: JK
authors.lastname: Oh
authors.forename: James D
authors.initials: JD
authors.lastname: Hoyer
authors.forename: Svetomir
authors.initials: S
authors.lastname: Markovic
authors.forename: Allan S
authors.initials: AS
authors.lastname: Jaffe
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D000787:Angina Pectoris / Q000209:etiology*; D001344:Autopsy; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D019210:Troponin I / Q000032:analysis*
chemical_list: D019210:Troponin I