title: Use of heliox in patients with severe exacerbation of chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  To assess whether patients with chronic obstructive pulmonary disease treated with heliox have a better prognosis than those treated with standard therapy.
  
  
  METHODS
  Retrospective analysis over 18 months.
  
  
  METHODS
  Academic emergency department.
  
  
  METHODS
  Eighty-one patients admitted with exacerbation of chronic obstructive pulmonary disease and respiratory acidosis.
  
  
  METHODS
  Use of helium-oxygen mixture as an adjunctive therapy.
  
  
  RESULTS
  The following data were collected: age, gender, medical history, vital signs, arterial blood gas at admission, emergency room treatment, requirement for intubation, admission in intensive care unit, length of stay, and evolution. Patients were classified into two groups according to whether heliox was used as a therapeutic agent (heliox group) or not (standard group). Chi-square test and Student's t-test were used for statistical analysis (significant at p <.05). In both groups, the following data were similar: age, gender, medical history, vital signs, initial arterial blood gas, and emergency room treatment. Significant decreases in intubation, and mortality rate were identified in the heliox group. Significant decreases in intensive care unit stay and in-hospital stay were observed for survivors in the heliox group.
  
  
  CONCLUSIONS
  Use of heliox seems to improve prognosis in patients with severe acute exacerbation of chronic obstructive pulmonary disease. Prospective randomized studies are needed to confirm these results.
authors.affiliation: Service d'Accueil des Urgences, Hôpital de la Conception, Marseille, France. pgerbeaux@mail.ap-hm.fr
authors.forename: P
authors.initials: P
authors.lastname: Gerbeaux
authors.forename: M
authors.initials: M
authors.lastname: Gainnier
authors.forename: A
authors.initials: A
authors.lastname: Boussuges
authors.forename: J
authors.initials: J
authors.lastname: Rakotonirina
authors.forename: P
authors.initials: P
authors.lastname: Nelh
authors.forename: D
authors.initials: D
authors.lastname: Torro
authors.forename: J M
authors.initials: JM
authors.lastname: Arnal
authors.forename: P
authors.initials: P
authors.lastname: Jean
mesh_terms: D000368:Aged; D005260:Female; D005602:France / Q000453:epidemiology; D006371:Helium / Q000627:therapeutic use*; D006801:Humans; D007040:Hypoventilation / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D008297:Male; D010100:Oxygen / Q000627:therapeutic use*; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D006371:Helium; C038949:heliox; D010100:Oxygen