Antimicrobial activity of prosthetic heart valve sewing cuffs coated with minocycline and rifampin.
Prosthetic heart valve sewing cuffs coated with minocycline and rifampin exhibited in vitro zones of inhibition against all 52 tested clinical isolates responsible for prosthetic valve endocarditis. An in vitro elution study of these coated sewing cuffs demonstrated residual zones of inhibition against Staphylococcus epidermidis for at least 4 weeks.
Darouiche
Rabih O
RO
Center for Prostheses Infection, Baylor College of Medicine and Veterans Affairs Medical Center, St. Luke's Episcopal Hospital, Houston, Texas 77030, USA. rdarouiche@aol.com
Fowler
Vance G
VG
Adal
Karim
K
Kielhofner
Marcia
M
Mansouri
David
D
Reller
L Barth
LB
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000494:pharmacology* / Q000627:therapeutic use; D001407:Bacillus / Q000187:drug effects; D004359:Drug Therapy, Combination; D006350:Heart Valve Prosthesis / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology* / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D012293:Rifampin / Q000494:pharmacology* / Q000627:therapeutic use; D013212:Staphylococcus epidermidis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D008911:Minocycline; D012293:Rifampin