Tetrabenazine fails to antagonize a behavioral effect of cocaine in rhesus monkeys.
For research and therapeutic purposes, a cocaine antagonist is an important drug development goal. The vesicular monoamine transport inhibitor tetrabenazine was tested for interaction with cocaine using food-reinforced responding in rhesus monkeys as an assay. Both tetrabenazine and cocaine suppressed food-maintained behavior individually. However, a low-dose tetrabenazine pretreatment did not alter the rate-suppressing effects of cocaine and cocaine did not alter the rate-suppressing effects of a high dose tetrabenazine pretreatment. Because tetrabenazine interacts with the monoamine oxidase inhibitor deprenyl in this assay, we conclude that cocaine does not produce an effect through vesicular catecholamines in this assay.
Koetzner
Lee
L
Department of Pharmacology, University of Michigan, 1301 MSRB III/1150 West Medical Center Drive, Ann Arbor, MI 48109-0632, USA.
Sumpter
Tina L
TL
Woods
James H
JH
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D018765:Dopamine Uptake Inhibitors / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D004347:Drug Interactions / Q000502:physiology; D005260:Female; D008253:Macaca mulatta; D008297:Male; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013747:Tetrabenazine / Q000494:pharmacology*
D018759:Adrenergic Uptake Inhibitors; D018765:Dopamine Uptake Inhibitors; D003042:Cocaine; D013747:Tetrabenazine