Quantification of optical properties of a breast tumor using random walk theory.
For the first time we use a random walk methodology based on time-dependent contrast functions to quantify the optical properties of breast tumors (invasive ductal carcinoma) of two patients. Previously this theoretical approach was successfully applied for analysis of embedded objects in several phantoms. Data analysis was performed on distributions of times of flight for photons transmitted through the breast which were recorded in vivo using a time-domain scanning mammograph at 670 and 785 nm. The size of the tumors, their optical properties, and those of the surrounding tissue were reconstructed at both wavelengths. The tumors showed increased absorption and scattering. From the absorption coefficients at both wavelengths blood oxygen saturation was estimated for the tumors and the surrounding tissue.
Chernomordik
Victor
V
National Institutes of Health, National Institute of Child Health and Development, Bethesda, Maryland, USA. vchern@helix.nih.gov
Hattery
David W
DW
Grosenick
Dirk
D
Wabnitz
Heidrun
H
Rinneberg
Herbert
H
Moesta
K Thomas
KT
Schlag
Peter M
PM
Gandjbakhche
Amir
A
D000042:Absorption; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007259:Infrared Rays; D008027:Light; D008327:Mammography; D008962:Models, Theoretical; D009361:Neoplasm Invasiveness; D055095:Optics and Photonics; D017785:Photons; D012542:Scattering, Radiation; D013997:Time Factors