Comparative analysis of FUR regulons in gamma-proteobacteria.
Iron is an essential element for the survival and pathogenesis of bacteria. The strict control of iron homeostasis is mediated by the FUR repressor, which is highly conserved among various bacterial species. Here we apply the comparative genomics approach to analyze candidate Fur-binding sites in the genomes of Escherichia coli (K12 and O157:H7), Salmonella typhi, Yersinia pestis and Vibrio cholerae. We describe a number of new loci encoding siderophore biosynthesis and transport proteins. A new regulator of iron-acquisition systems was found in S.typhi. We predict FUR regulation for several virulence systems. We also predict FUR regulation for the chemotaxis system of V.cholerae that is probably involved in the process of pathogenesis.
Panina
E M
EM
State Scientific Center GosNIIGenetika, 1st Dorozhny prospect, Moscow 113545, Russia. katya@ekpanina.mccme.ru
Mironov
A A
AA
Gelfand
M S
MS
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D020563:Gammaproteobacteria / Q000235:genetics* / Q000378:metabolism; D005798:Genes, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D007501:Iron / Q000378:metabolism*; D008969:Molecular Sequence Data; D012097:Repressor Proteins / Q000235:genetics*; D012485:Salmonella typhi / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014734:Vibrio cholerae / Q000235:genetics / Q000378:metabolism; D015010:Yersinia pestis / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D012097:Repressor Proteins; C068477:ferric uptake regulating proteins, bacterial; D007501:Iron