Oral precancerous and malignant lesions associated with graft-versus-host disease: report of 2 cases.
The development of secondary malignancies has been recognized as a potential iatrogenic complication in patients who have graft-versus-host disease secondary to bone marrow transplantation. Lymphohematopoietic cancer is most frequent, although solid malignancies have also been reported. We describe 2 patients with graft-versus-host disease who developed oral precancerous and malignant lesions. The first patient, a 24-year-old white man, had erythroplakia of the buccal mucosa that proved to be carcinoma in situ histopathologically. The second patient, a 14-year-old Hispanic boy, developed synchronous cutaneous and lingual squamous cell carcinomas. The current cases and similar sporadic case reports found in the literature highlight the susceptibility of patients with graft-versus-host disease to the development of oral cancer. Therefore, it is recommended that thorough evaluation of the oral mucosa and close follow-up be offered to all patients treated with bone marrow transplantation and particularly to those who develop graft-versus-host disease.
Abdelsayed
Rafik A
RA
Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta 30912, USA. rabdelsa@mail.mcg.edu
Sumner
Ty
T
Allen
Carl M
CM
Treadway
Antwan
A
Ness
Gregory M
GM
Penza
Sam L
SL
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002278:Carcinoma in Situ / Q000209:etiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology; D004919:Erythroplasia / Q000209:etiology / Q000473:pathology; D006086:Graft vs Host Disease / Q000150:complications* / Q000209:etiology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000209:etiology* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000209:etiology*; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology; D014062:Tongue Neoplasms / Q000209:etiology / Q000473:pathology