[Infection hypothesis of coronary heart disease].
It is well accepted that coronary artery disease is linked to an inflammatory process. It is unproven however whether either infectious agents may cause or accelerate coronary artery disease or the inflammatory process is due to metabolic or toxic effects. Among the possible infectious agents Chlamydia pneumoniae is the most likely bacterium involved in atherosclerosis. The arguments in favour of Chlamydia pneumoniae originate from seroepidemiologic studies and from detection and isolation of bacteria from vascular lesions. This review summarises the present understanding of the role of bacterial infection for development or progression of coronary artery disease.
Jahn
J
J
Medizinische Klinik II, Medizinische Universität Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Deutschland. jahn@medinf.mu-luebeck.de
Hellmann
I
I
Kothe
H
H
Maass
M
M
Dalhoff
K
K
Katus
H A
HA
D000818:Animals; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000472:pathogenicity*; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D014774:Virulence